Anti-infective and cytotoxic compounds present in Blepharodon nitidum.
A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3beta-ol and 25-hydroperoxycycloart-23-en-3beta-ol, exhibited in vitro anti- Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.
Aponte
José C
JC
Department of Chemistry, University of Louisville, Louisville, KY, U.S.A.
Estevez
Yannick
Y
Gilman
Robert H
RH
Lewis
Walter H
WH
Rojas
Rosario
R
Sauvain
Michel
M
Vaisberg
Abraham J
AJ
Hammond
Gerald B
GB
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure
D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic