title: [Increasing the solubility and permeability of pharmacons with pharmaceutical technological methods].
abstract: During the last years the trend in drug discovery has been to produce more and more compounds that exhibit high lipophilicity and poor water solubility. If a drug candidate has reasonable membrane permeability--the pharmacon belongs to the second group of the biopharmaceutical classification system (BCS)--then often the rate-limiting process of absorption is the drug dissolution step. There are a number of formulation strategies that could be used to improve the bioavailability of these materials. In this article the author would like to collect the technological possibilities, and gives some samples from the results of the research group of the Department of Pharmaceutical Technology, University of Szeged.
authors.affiliation: Szegedi Tudományegyetem, Gyógyszertechnológiai Intézet, Szeged, Eötvös u. 6. - 6720.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Aigner
mesh_terms: D004358:Drug Therapy; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility
chemical_list: D004364:Pharmaceutical Preparations