Artificial circulation of the liver: machine perfusion as a preservation method in liver transplantation.
Due to the sharp increase in liver transplant candidates and the subsequent shortage of suitable donor livers, an extension of the current donor criteria is necessary. Simple cold storage, the current standard in organ preservation has proven to be insufficient to preserve extended criteria donor livers. Therefore a renewed interest grew toward alternative methods for liver preservation, such as hypothermic machine perfusion and normothermic machine perfusion. These "new" preservation methods were primarily assessed in rat models, and only a few clinically relevant large animal models have been described so far. This review will elaborate on these alternative preservation methods.
Vekemans
Katrien
K
Abdominal Transplant Surgery, Catholic University of Leuven (KULeuven), Leuven, Belgium. katrien.vekemans@med.kuleuven.be
Liu
Qiang
Q
Pirenne
Jacques
J
Monbaliu
Diethard
D
D000818:Animals; D004285:Dogs; D006801:Humans; D008102:Liver Circulation; D016031:Liver Transplantation / Q000379:methods*; D023421:Models, Animal; D009926:Organ Preservation / Q000295:instrumentation / Q000379:methods*; D019188:Organ Preservation Solutions; D010477:Perfusion / Q000295:instrumentation / Q000379:methods; D011817:Rabbits; D051381:Rats; D034421:Sus scrofa; D013696:Temperature
D019188:Organ Preservation Solutions