Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry.
Chen et al. found that the CA haplotype of protein C -1654C/T and -1641G/A was associated with increased risk of death and organ dysfunction in Chinese Han patients with severe sepsis (Hum Genet 123:281-287, 2008). We similarly tested for association of the C allele of protein C 673 T/C (rs2069912) (linkage disequilibrium with the CA haplotype, D' = 100%) in a cohort of 100 North American East Asians with severe sepsis. The C allele was associated with increased mortality and organ dysfunction, consistent with Chen et al.
Russell
James A
JA
University of British Columbia Critical Care Research Laboratories, 1081 Burrard Street, Vancouver, BC, Canada. jrussell@mrl.ubc.ca
Wellman
Hugh
H
Walley
Keith R
KR
D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005202:Asia, Eastern / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology / Q000235:genetics / Q000401:mortality; D009656:North America / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D011486:Protein C / Q000235:genetics*; D018805:Sepsis / Q000150:complications / Q000235:genetics* / Q000401:mortality*
D011486:Protein C