title: Poor outcomes of chronic active Epstein-Barr virus infection and hemophagocytic lymphohistiocytosis in non-Japanese adult patients.
abstract: Chronic active Epstein-Barr virus infection manifests as a combination of persistent infectious mononucleosis-like symptoms and high viral load in apparently immunocompetent patients. It is closely related to Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. These 2 abnormal Epstein-Barr virus-associated diseases are seldom reported in individuals other than Japanese children and adolescents. We report a series of 2 adult non-Japanese patients with fatal chronic active Epstein-Barr virus and 1 adult non-Japanese patient with Epstein-Barr virus hemophagocytic lymphohistiocytosis and discuss its pathogenesis and treatment options.
authors.affiliation: Departments of 1Medical Oncology and 2Pathology, Antoni van Leeuwenhoek Hospital-Netherlands Cancer Institute, 1006 BE Amsterdam, The Netherlands. g.sonke@nki.nl
authors.forename: Gabe S
authors.initials: GS
authors.lastname: Sonke
authors.forename: Inge
authors.initials: I
authors.lastname: Ludwig
authors.forename: Hannah
authors.initials: H
authors.lastname: van Oosten
authors.forename: Joke W
authors.initials: JW
authors.lastname: Baars
authors.forename: Ellen
authors.initials: E
authors.lastname: Meijer
authors.forename: Arnon P
authors.initials: AP
authors.lastname: Kater
authors.forename: Daphne
authors.initials: D
authors.lastname: de Jong
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D020031:Epstein-Barr Virus Infections / Q000401:mortality* / Q000473:pathology / Q000628:therapy / Q000821:virology; D017809:Fatal Outcome; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000401:mortality* / Q000473:pathology / Q000628:therapy / Q000821:virology; D008297:Male; D008875:Middle Aged; D019562:Viral Load
chemical_list: D000914:Antibodies, Viral