title: One-lung overventilation does not induce inflammation in the normally ventilated contralateral lung.
abstract: The aim was to assess whether induction of ventilator-induced lung injury (VILI) in one lung triggers a concomitant inflammatory response in the normally ventilated contralateral lung. To this end, a differential ventilator was used in 6 rats. One lung was normally ventilated (3.5 ml/kg b.w.) and the contralateral lung was overstretched (15 ml/kg b.w.). Six control rats were normally ventilated (3.5 ml/kg b.w. each lung). After 3h, edema and gene expression of MIP-2 in the lung, and plasma and liver TNF-alpha were assessed. Overexpression of MIP-2 and edema were found in the overventilated lung but not in the normally ventilated contralateral lung. No detectable levels of circulating and liver TNF-alpha were detected. These data do not support the hypothesis of an early positive feedback in the lung inflammation during the mechanical ventilation.
authors.affiliation: Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona-IDIBAPS, Barcelona, Spain.
authors.forename: Isaac
authors.initials: I
authors.lastname: Almendros
authors.forename: Patricia T
authors.initials: PT
authors.lastname: Gutierrez
authors.forename: Daniel
authors.initials: D
authors.lastname: Closa
authors.forename: Daniel
authors.initials: D
authors.lastname: Navajas
authors.forename: Ramon
authors.initials: R
authors.lastname: Farre
mesh_terms: D000818:Animals; D054426:Chemokine CXCL2 / Q000235:genetics / Q000378:metabolism; D007839:Functional Laterality / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D007249:Inflammation / Q000209:etiology* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration; D012121:Respiration, Artificial / Q000009:adverse effects*; D018709:Statistics, Nonparametric; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D054426:Chemokine CXCL2; D014409:Tumor Necrosis Factor-alpha