Two new 5-hydroxy-2-pyrone derivatives isolated from a marine-derived fungus Aspergillus flavus.
Two new compounds, 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (1) and (5-hydroxy-2-oxo-2H-pyran-4-yl) methyl acetate (2), have been isolated from a marine-derived fungus Aspergillus flavus. Their structures were determined by spectroscopic data. Compound 1 induced the production of cAMP on GPR12 transfected CHO and HEK293 cells in a dose-dependent manner, which indicated 1 might be a possible ligand for GPR12.
Lin
Aiqun
A
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China.
Lu
Xiaoming
X
Fang
Yuchun
Y
Zhu
Tianjiao
T
Gu
Qianqun
Q
Zhu
Weiming
W
D000818:Animals; D001231:Aspergillus flavus / Q000378:metabolism*; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization; D014871:Water Microbiology
C097350:GPR12 protein, human; D011753:Pyrones; D043562:Receptors, G-Protein-Coupled