title: Sleep rebound attenuates context-dependent behavioural sensitization induced by amphetamine.
abstract: We have recently demonstrated that paradoxical sleep deprivation (PSD) potentiates the induction of amphetamine (AMPH)-induced behavioural sensitization by increasing its conditioned component. In the present study, the effects of sleep rebound (induced by 24 h recovery period from PSD) were studied on AMPH-induced behavioural sensitization. Sleep rebound attenuated the acute locomotor-stimulating effect of AMPH. AMPH-induced behavioural sensitization was context-specific and was also attenuated by sleep rebound. These results strengthen the notion that sleep conditions can influence AMPH-induced behavioural sensitization.
authors.affiliation: Department of Pharmacology, Universidade Federal de São Paulo, Rua Botucatu, 862, Edifício Leal Prado, CEP 04023-062 São Paulo, SP, Brazil.
authors.forename: Mariana Bendlin
authors.initials: MB
authors.lastname: Calzavara
authors.forename: Monica Levy
authors.initials: ML
authors.lastname: Andersen
authors.forename: Daniela Fukue
authors.initials: DF
authors.lastname: Fukushiro
authors.forename: Giorgia Batlle
authors.initials: GB
authors.lastname: Lopez
authors.forename: Vanessa Costhek
authors.initials: VC
authors.lastname: Abílio
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.forename: Roberto
authors.initials: R
authors.lastname: Frussa-Filho
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects*; D008124:Locomotion / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects* / Q000502:physiology
chemical_list: D000697:Central Nervous System Stimulants; D000661:Amphetamine