[RANTES expression in venous ulceration of lower limbs].
OBJECTIVE
To investigate the expression of RANTES in venous ulceration.


METHODS
From patients with lower limb venous ulceration, patients with non-ulcerous venous insufficiency, and healthy individuals, peripheral blood was collected from the lower limb veins for measurement of RANTES mRNA using RT-PCR.


RESULTS
In the ulceration group, the expression of RANTES mRNA was significantly increased as compared with the other two groups (P<0.01). RANTES mRNA expression was also significant higher in the non-ulcerous group than the control group (P<0.01).


CONCLUSIONS
High expression of RANTES mRNA may be one of the important mechanisms of venous ulceration.
Chen
Liu-hua
LH
Department of Vascular Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. chlh22@163.com
Ye
Cai-sheng
CS
Yin
Heng-hui
HH
Ye
Jie-lian
JL
Wang
Shen-ming
SM
D000328:Adult; D000368:Aged; D018946:Chemokine CCL5 / Q000096:biosynthesis / Q000097:blood* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014647:Varicose Ulcer / Q000097:blood* / Q000209:etiology; D014689:Venous Insufficiency / Q000097:blood* / Q000150:complications; D055815:Young Adult
D018946:Chemokine CCL5; D012333:RNA, Messenger