title: Naphthalecin, a novel antibiotic produced by the anaerobic bacterium, Sporotalea colonica sp. nov.
abstract: A novel antibiotic naphthalecin was purified and isolated from the cells of an anaerobic bacterium isolated from a soil sample. This antibiotic contained a naphthalene moiety, so named as naphthalecin, and showed antibacterial activity against gram positive species. The producing strain, an obligate anaerobe, was identified as a new species of the genus Sporotalea. Identification of the bacterium, cultivation, purification, structure determination, and antibacterial activity are shown.
authors.affiliation: Fermentation Research Laboratories, Drug Discovery Research, Astellas Pharma Inc, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Ezaki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Muramatsu
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Takase
authors.forename: Michizane
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Koji
authors.initials: K
authors.lastname: Nagai
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009284:Naphthols / Q000097:blood* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010802:Phylogeny; D045854:Veillonellaceae / Q000145:classification* / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D009284:Naphthols; C530701:naphthalecin