title: Myelin proteolipid protein: an effective autoantigen and target of autoimmunity in multiple sclerosis.
abstract: Myelin proteolipid protein (PLP) is the most abundant protein in central nervous system (CNS) myelin and plays a major role in maintaining the structural and functional integrity of myelin. Its abundance in, and restriction to, CNS myelin and its post-translational modification by acylation make PLP an effective autoantigen, which can induce experimental autoimmune encephalomyelitis in rodents and non-human primates and which is a target of pathogenic autoimmunity in people with multiple sclerosis, a chronic inflammatory demyelinating CNS disease.
authors.affiliation: School of Medicine, The University of Queensland, Brisbane, Qld 4072, Australia. j.greer@uq.edu.au
authors.forename: Judith M
authors.initials: JM
authors.lastname: Greer
authors.forename: Michael P
authors.initials: MP
authors.lastname: Pender
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology* / Q000378:metabolism; D015551:Autoimmunity; D002490:Central Nervous System / Q000276:immunology* / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D009103:Multiple Sclerosis / Q000209:etiology / Q000276:immunology* / Q000378:metabolism; D018991:Myelin Proteolipid Protein / Q000276:immunology* / Q000378:metabolism
chemical_list: D001324:Autoantigens; D018991:Myelin Proteolipid Protein