Caveats of caveolin-1 in cancer progression.
Caveolin-1, an essential scaffold protein of caveolae and cellular transport processes, lately gained recognition as a stage- and tissue-specific tumor modulator in vivo. Patient studies and rodent models corroborated its janus-faced role as a tumor suppressor in non-neoplastic tissue, its down-regulation (loss of function) upon transformation and its re-expression (regain of function) in advanced-stage metastatic and multidrug resistant tumors. This review is focussed on the role of caveolin-1 in metastasis and angiogenesis and its clinical implications as a prognostic marker in cancer progression.
Burgermeister
Elke
E
Department of Medicine II, Klinikum Rechts der Isar, Technical University of München, München, Germany. elke.burgermeister@lrz.tum.de
Liscovitch
Mordechai
M
Röcken
Christoph
C
Schmid
Roland M
RM
Ebert
Matthias P A
MP
D000818:Animals; D017209:Apoptosis; D051242:Caveolin 1 / Q000032:analysis / Q000502:physiology*; D002448:Cell Adhesion; D002470:Cell Survival; D018450:Disease Progression; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000209:etiology* / Q000401:mortality; D009389:Neovascularization, Pathologic / Q000209:etiology; D011379:Prognosis
D051242:Caveolin 1