Trimetazidine revisited: a comprehensive review of the pharmacological effects and analytical techniques for the determination of trimetazidine.
Trimetazidine (TMZ) is an effective and well-tolerated antianginal drug that possesses protective properties against ischemia-induced heart injury. Growing interest in metabolic modulation in recent years urged an up-to-date review of the literature on TMZ. This review consists of two major sections: (1) comprehensive and critical information about the pharmacological effects, mechanism of action, pharmacokinetics, side effects, and current usage of TMZ, and (2) developments in analytical techniques for the determination of the drug in raw material, pharmaceutical dosage forms, and biological samples.
Onay-Besikci
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Department of Pharmacology, Faculty of Pharmacy, Ankara University, Tandogan, Ankara, Turkey. onay@pharmacy.ankara.edu.tr
Ozkan
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SA
D000818:Animals; D000975:Antioxidants / Q000009:adverse effects / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000009:adverse effects / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D002845:Chromatography / Q000379:methods; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects / Q000503:physiopathology; D004563:Electrochemistry; D004734:Energy Metabolism / Q000187:drug effects; D017022:Flow Injection Analysis; D006331:Heart Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007511:Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008163:Luminescent Measurements; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D013053:Spectrophotometry; D014292:Trimetazidine / Q000009:adverse effects / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use
D000975:Antioxidants; D002317:Cardiovascular Agents; D017382:Reactive Oxygen Species; D014292:Trimetazidine