[Progress in studies of the male reproductive toxicity of pyrethroid insecticides].
As a new type of pesticides and because of their high performance and low toxicity, pyrethroid insecticides are widely used in place of organochlorine insecticides both in agriculture and in the home. In the recent years, more and more evidence indicates that pyrethroid insecticides can reduce sperm count and motility, cause deformity of the sperm head, increase the count of abnormal sperm, damage sperm DNA and induce its aneuploidy rate, as well as affect sex hormone levels and produce reproductive toxicity. The present article reviews the advances in the studies of male reproductive toxicity of pyrethroid pesticides by experiment in animals and human population, discusses the mechanism of male reproductive toxicity of pesticides and raises some problems concerning the evaluation of human reproductive hazards.
Yao
Ke-Wen
KW
Graduate School of Peking Union Medical College, Beijing 100730, China.
Wang
Jie-Dong
JD
D000818:Animals; D005837:Genitalia, Male / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007306:Insecticides / Q000506:poisoning / Q000633:toxicity*; D008297:Male; D051379:Mice; D011722:Pyrethrins / Q000506:poisoning / Q000633:toxicity*; D051381:Rats; D018675:Toxicity Tests
D007306:Insecticides; D011722:Pyrethrins