Ainsliadimer A, a new sesquiterpene lactone dimer with an unusual carbon skeleton from Ainsliaea macrocephala.
A phytochemical investigation of Ainsliaea macrocephala led to the isolation of a new dimeric sesquiterpene lactone, ainsliadimer A (1). The structure of 1 was elucidated by spectroscopic analysis, and confirmed by single crystal X-ray diffraction. Ainsliadimer A represents an unusual carbon skeleton with a cyclopentane system connecting the two monomeric sesquiterpene lactone units. This unique molecule exerted potent inhibitory activity against the production of nitric oxide in RAW264.7 stimulated by LPS.
Wu
Zhi-Jun
ZJ
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai, PR China.
Xu
Xi-Ke
XK
Shen
Yun-Heng
YH
Su
Juan
J
Tian
Jun-Mian
JM
Liang
Shuang
S
Li
Hui-Liang
HL
Liu
Rui-Hui
RH
Zhang
Wei-Dong
WD
D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
D007783:Lactones; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; C530462:ainsliadimer A; D009569:Nitric Oxide