title: Efficient base catalyzed alkylation reactions with aziridine electrophiles.
abstract: N-Mesitylene sulfonyl and N-tosyl aziridines have been identified as effective electrophiles in alkylation reactions of carbon acids catalyzed by the organic phosphorine base BEMP; yields of up to 99% for a range of pro-nucleophiles under mild reaction conditions are reported.
authors.affiliation: School of Chemistry, The University of Manchester, Oxford Road, Manchester, UKM13 9PL.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Moss
authors.forename: Aurelie
authors.initials: A
authors.lastname: Alba
authors.forename: David
authors.initials: D
authors.lastname: Hepworth
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Dixon
mesh_terms: D000478:Alkylation; D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001388:Aziridines; D004952:Esters; D006573:Heterocyclic Compounds, 1-Ring; D009943:Organophosphorus Compounds; C116638:BEMP phosphazene