Total synthesis of sanguiin H-5.
Using an atropdiastereoselective oxidative biaryl coupling as the key step, the total synthesis of the ellagitannin natural product sanguiin H-5 is reported. Both organomagnesium and organozinc based metalation methodologies were used to efficiently construct the strained medium-ring core of the natural product.
Su
Xianbin
X
Department of Chemistry, University of Cambridge, Cambridge, UK.
Surry
David S
DS
Spandl
Richard J
RJ
Spring
David R
DR
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D047348:Hydrolyzable Tannins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D001688:Biological Products; D047348:Hydrolyzable Tannins; C530468:sanguiin H-5