title: Metabolic syndrome in an island population of the eastern Adriatic coast of Croatia.
abstract: The metabolic syndrome, an assemblage of risk factors, viz., obesity, dyslipidemia, carbohydrate intolerance, and hypertension, associated with development of cardiovascular diseases and Type 2 diabetes, has become a major public health problem in the developed countries. However, data on its prevalence in worldwide populations, particularly in non-industrialized societies is sparse. We report the prevalence of metabolic syndrome in an island population of the eastern Adriatic coast of Croatia, a distinctly homogenous population living in relative isolation with a traditional way of life style pattern. The participants consist of 381 unrelated individuals (136 males, 245 females) from the island of Hvar, age 19 and above. Hvar is among the most populated Croatian islands with a total population of 11,459 individuals according to the 1991 census. Metabolic syndrome was assessed following the National Cholesterol Education Program (NCEP) criteria, with the exception of using body mass index and waist hip ratio as the predictors of obesity. Overall age-adjusted prevalence of metabolic syndrome is 26% (32% in males and 24% in females) with body mass index, and 42% (57% in males and 36% in females) with waist hip ratio as the measures of obesity. Pairwise correlations of the age and sex-adjusted individual components show that with the exception of fasting plasma glucose, the other components of metabolic syndrome are significantly associated with each other, suggesting their co-morbidity. In spite of adherence to a relatively traditional life-style pattern together with a "Mediterranean diet" and rural habitat, the prevalence of metabolic syndrome is substantially high in the population of Hvar. It is likely that factors other than nutritional practices, that might include genetic susceptibility, could potentially be important in predisposition to metabolic syndrome.
authors.affiliation: Department of Environmental Health, Center for Genome Information, University of Cincinnati, Cincinnati, OH 45267, USA. ranjan.deka@uc.edu
authors.forename: Ranjan
authors.initials: R
authors.lastname: Deka
authors.forename: Nina Smolej
authors.initials: NS
authors.lastname: Narancić
authors.forename: Huifeng
authors.initials: H
authors.lastname: Xip
authors.forename: Stjepan
authors.initials: S
authors.lastname: Turek
authors.forename: Mirjana
authors.initials: M
authors.lastname: Cubrilo-Turek
authors.forename: Danijela
authors.initials: D
authors.lastname: Vrhovski-Hebrang
authors.forename: Branka
authors.initials: B
authors.lastname: Janićijević
authors.forename: Andrea
authors.initials: A
authors.lastname: Tomljenović
authors.forename: Lajos
authors.initials: L
authors.lastname: Szirovicza
authors.forename: Li
authors.initials: L
authors.lastname: Jin
authors.forename: Ranajit
authors.initials: R
authors.lastname: Chakraborty
authors.forename: Pavao
authors.initials: P
authors.lastname: Rudan
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D017523:Croatia / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D049629:Waist-Hip Ratio