title: Is there a relationship between prostate volume and Gleason score?
abstract: OBJECTIVE
  To review the relationship between the Gleason grade and prostate volume in biopsy and radical prostatectomy (RP) specimens, and thus assess the hypothesis that smaller prostates have a greater incidence of high-grade tumours.
  
  
  METHODS
  We selected 390 patients who had RP at our institution, with a prostate-specific antigen (PSA) level of < 10 ng/mL and who had not had hormonal therapy. We retrospectively reviewed the data for transrectal ultrasonography (TRUS)-guided prostate biopsies from these patients and the RP specimens. Indications for biopsy included a PSA level of > or = 4 ng/mL or an abnormal digital rectal examination. High-grade tumours were defined as having a Gleason score of > or = 7.
  
  
  RESULTS
  The TRUS volume was statistically related to the rate of high-grade tumours at biopsy and RP. On multivariate analyses, TRUS volume was a significant predictor of high-grade tumour for biopsy and RP specimens, with an inverse relationship between high-grade tumours and prostate volume for biopsy and RP specimens.
  
  
  CONCLUSIONS
  Our data suggest that there is a relationship between the rate of high-grade tumours and prostate volume even in biopsy and RP specimens and it is not an artefact related to the biopsy.
authors.affiliation: Department of Urology, Vall d'Hebron Hospital, Autonoma University School of Medicine, Barcelona, Spain. mirmare@yahoo.es
authors.forename: Maria Carmen
authors.initials: MC
authors.lastname: Mir
authors.forename: Jacques
authors.initials: J
authors.lastname: Planas
authors.forename: Carles Xavier
authors.initials: CX
authors.lastname: Raventos
authors.forename: Ines Maria
authors.initials: IM
authors.lastname: de Torres
authors.forename: Enrique
authors.initials: E
authors.lastname: Trilla
authors.forename: Lluis
authors.initials: L
authors.lastname: Cecchini
authors.forename: Anna
authors.initials: A
authors.lastname: Orsola
authors.forename: Juan
authors.initials: J
authors.lastname: Morote
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging / Q000379:methods; D009929:Organ Size; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D018084:Ultrasonography, Interventional / Q000379:methods
chemical_list: D017430:Prostate-Specific Antigen