The Yin and Yang of YY1 in the nervous system.
The transcription factor Yin Yang 1 (YY1) is a multifunctional protein that can activate or repress gene expression depending on the cellular context. YY1 is ubiquitously expressed and highly conserved between species. However, its role varies in diverse cell types and includes proliferation, differentiation, and apoptosis. This review will focus on the function of YY1 in the nervous system including its role in neural development, neuronal function, developmental myelination, and neurological disease. The multiple functions of YY1 in distinct cell types are reviewed and the possible mechanisms underlying the cell specificity for these functions are discussed.
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Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA. heye@umdnj.edu
Casaccia-Bonnefil
Patrizia
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D000818:Animals; D006801:Humans; D009186:Myelin Sheath / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D009420:Nervous System / Q000737:chemistry / Q000196:embryology / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D050986:YY1 Transcription Factor / Q000737:chemistry / Q000502:physiology*
D050986:YY1 Transcription Factor; C494698:YY1 protein, human