A new entry to 1,5-keto esters and their 4,4-dideuterio derivatives via methylene chloride as "methylene dianion" equivalents.
This TiCl 4-Mg promoted multicomponent coupling of various amides with CH(2)Cl(2) and methyl acrylate represents an extremely simple and practical synthesis of 1,5-keto esters. The efficiency of this chemistry is illustrated by the very simple preparation of unusual 4,4-dideuterio-1,5-keto esters.
Lin
Kuo-Wei
KW
Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan, ROC.
Chen
Cheng-Yih
CY
Chen
Wei-Fan
WF
Yan
Tu-Hsin
TH