A domino annulation reaction under Willgerodt-Kindler conditions.
Butanone side chains at arenes and hetarenes, efficiently introduced by a Heck-type reaction, are transformed to annulated thieno[3,2-b]thiophenes in a domino redox process under Willgerodt-Kindler conditions. A nucleophilic aromatic substitution with an intermediary thioenolate is a reasonable key step of this process.
Kadzimirsz
Daniel
D
Faculty of Chemistry & Biochemistry, Ruhr-Universität Bochum, Bochum, Germany.
Kramer
Daniel
D
Sripanom
Lertnarong
L
Oppel
Iris M
IM
Rodziewicz
Pawel
P
Doltsinis
Nikos L
NL
Dyker
Gerald
G