title: [Modeling dynamics of decompression disease risk under high-altitude decompression].
abstract: The probabilistic model of the development of decompression disease was modified by introducing the corrections into its equation that refine the dependence of the risk of the injury of tissues by gas bubbles on their blood supply and the intensity of nucleation processes. The parameters of the "worst" virtual tissues and theoretical curves were determined that correspond to the empirical data on the cumulative probability of the development of decompression disease symptoms during some procedures of high-altitude decompression. It was shown that the parameters of these hypothetical tissues depend on the final pressure, the physical load, and the duration ofpreoxygenation. The ways of constructing a working hypothesis about the gradation of real body tissues with respect to the parameters determining the risk of their injury by bubbles and developing the method for the theoretical prognosis of the probability of development of decompression disease during any decompression procedure are discussed.
authors.forename: V P
authors.initials: VP
authors.lastname: Nikolaev
mesh_terms: D000531:Altitude; D001274:Atmospheric Pressure; D003664:Decompression / Q000009:adverse effects*; D003665:Decompression Sickness / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological