title: Cytotoxicity of Triorganophosphinegold(I) n-Mercaptobenzoates, n = 2, 3 and 4.
abstract: The results of cytotoxicity trials against a panel of seven human cell lines for a series of triorganophosphinegold(I) 3- and 4-mercaptobenzoates are reported. While the new compounds show moderate to high toxicity, their potencies are inferior to those reported previously for their isomeric 2- mercaptobenzoate derivatives. The results therefore suggest a structure-activity relationship in that the 2-isomeric species are more active, particularly against the non-small cell lung cancer and renal cancer cell lines, results that may indicate some selectivity in their cytotoxic profile.
authors.affiliation: Medical Department Pharmachemie B.V. Haarlem NL-2003 The Netherlands.
authors.forename: Dick
authors.initials: D
authors.lastname: de Vos
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Smyth
authors.forename: Edward R T
authors.initials: ER
authors.lastname: Tiekink