title: [Acute generalized exanthematous pustulosis associated with diltiazem].
abstract: Acute generalized exanthematous pustulosis (AGEP) usually presents with the acute appearance of oedematous and erythematous lesions, on which multiple sterile pustules appear, associated with fever. Almost 90% of cases are associated with drugs, with antibiotics (penicillins and macrolides) being the most frequent causative agents. We describe a 36-year-old female patient, which started diltiazem 120mg/day for hypertension. After 6 days of therapy, multiple erythematous and oedematous lesions appeared, with associated multiple small non-follicular pustules. Oral corticosteroids were started, with progressive and complete improvement. Patch-tests were performed, which revealed positivity for diltiazem. Although a rare entity, AGEP must be considered in cases of acute eruptions with disseminated pustules and fever. The use of patch tests in this disease may be useful as positive reactions are frequent.
authors.affiliation: Serviço de Dermatologia, Hospital dos Capuchos, Lisboa.
authors.forename: Vasco
authors.initials: V
authors.lastname: Serrão
authors.forename: Luísa
authors.initials: L
authors.lastname: Caldas Lopes
authors.forename: J M
authors.initials: JM
authors.lastname: Campos Lopes
authors.forename: Lurdes
authors.initials: L
authors.lastname: Lobo
authors.forename: Ana
authors.initials: A
authors.lastname: Ferreira
mesh_terms: D000208:Acute Disease; D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects*; D004110:Diltiazem / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005076:Exanthema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*
chemical_list: D000959:Antihypertensive Agents; D004110:Diltiazem