title: Endoscopic ultrasound: it's accuracy in evaluating mediastinal lymphadenopathy? A meta-analysis and systematic review.
abstract: OBJECTIVE
  To evaluate the accuracy of endoscopic ultrasound (EUS), EUS-fine needle aspiration (FNA) in evaluating mediastinal lymphadenopathy.
  
  
  METHODS
  Only EUS and EUS-FNA studies confirmed by surgery or with appropriate follow-up were selected. Articles were searched in Medline, Pubmed, and Cochrane control trial registry. Only studies from which a 2 multiply 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratios. Pooling was conducted by both Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran's Q test based upon inverse variance weights.
  
  
  RESULTS
  Data was extracted from 76 studies (n = 9310) which met the inclusion criteria. Of these, 44 studies used EUS alone and 32 studies used EUS-FNA. FNA improved the sensitivity of EUS from 84.7% (95% CI: 82.9-86.4) to 88.0% (95% CI: 85.8-90.0). With FNA, the specificity of EUS improved from 84.6% (95% CI: 83.2-85.9) to 96.4% (95% CI: 95.3-97.4). The P for chi-squared heterogeneity for all the pooled accuracy estimates was > 0.10.
  
  
  CONCLUSIONS
  EUS is highly sensitive and specific for the evaluation of mediastinal lymphadenopathy and FNA substantially improves this. EUS with FNA should be the diagnostic test of choice for evaluating mediastinal lymphadenopathy.
authors.affiliation: Division of Gastroenterology and Hepatollogy, University of Missouri-Columbia, Columbia, MO 65212, USA.
authors.forename: Srinivas-R
authors.initials: SR
authors.lastname: Puli
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Batapati Krishna Reddy
authors.forename: Matthew-L
authors.initials: ML
authors.lastname: Bechtold
authors.forename: Jamal-A
authors.initials: JA
authors.lastname: Ibdah
authors.forename: Daphne
authors.initials: D
authors.lastname: Antillon
authors.forename: Shailender
authors.initials: S
authors.lastname: Singh
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Olyaee
authors.forename: Mainor-R
authors.initials: MR
authors.lastname: Antillon
mesh_terms: D015982:Bias; D044963:Biopsy, Fine-Needle; D019160:Endosonography; D006801:Humans; D008206:Lymphatic Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D008477:Mediastinal Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors