title: A direct stereoselective approach to trans-2,3-disubstituted piperidines: application in the synthesis of 2-Epi-CP-99,994 and (+)-epilupinine.
abstract: A simple synthesis of enantiomerically pure piperidine esters is described, offering a straightforward access to the trans-2,3-disubstituted piperidine skeleton which is present in a broad range of biologically active compounds.
authors.affiliation: Institut de Chimie Moléculaire de Reims, CNRS (UMR 6229), Université de Reims, Reims Cedex 2, France.
authors.forename: M'hamed
authors.initials: M
authors.lastname: Ahari
authors.forename: Amandine
authors.initials: A
authors.lastname: Perez
authors.forename: Christine
authors.initials: C
authors.lastname: Menant
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Vasse
authors.forename: Jan
authors.initials: J
authors.lastname: Szymoniak
mesh_terms: D003500:Cyclization; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry; D013034:Sparteine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D000093843:Quinolizidine Alkaloids
chemical_list: D010880:Piperidines; D013034:Sparteine; C080755:3-(2-methoxybenzylamino)-2-phenylpiperidine; C015971:lupinine; D000093843:Quinolizidine Alkaloids