Benzyne click chemistry: synthesis of benzotriazoles from benzynes and azides.
A variety of substituted benzotriazoles have been prepared by the [3 + 2] cycloaddition of azides to benzynes. The reaction scope is quite general, affording a rapid and easy entry to substituted, functionalized benzotriazoles under mild conditions.
Shi
Feng
F
Department of Chemistry, Iowa State University, Ames, IA 50010, USA.
Waldo
Jesse P
JP
Chen
Yu
Y
Larock
Richard C
RC
D001386:Azides / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D014230:Triazoles / Q000138:chemical synthesis*
D001386:Azides; D001555:Benzene Derivatives; D014230:Triazoles; C524146:benzyne; C012771:benzotriazole