title: Heterogeneous memory T cells in antiviral immunity and immunopathology.
abstract: Memory T cells are generated following an initial viral infection, and have the potential for mediating robust protective immunity to viral re-challenge due to their rapid and enhanced functional responses. In recent years, it has become clear that the memory T cell response to most viruses is remarkably diverse in phenotype, function, and tissue distribution, and can undergo dynamic changes during its long-term maintenance in vivo. However, the role of this variegation and compartmentalizationof memory T cells in protective immunity to viruses remains unclear. In this review,we discuss the diverse features of memory T cells that can delineate different subsets, the characteristics of memory T cells thus far identified to promote protective immune responses, and how the heterogeneous nature of memory T cells may also promote immunopathology during antiviral responses. We propose that given the profound heterogeneity of memory T cells, regulation of memory T cells during secondary responses could focus the response to participation of specific subsets,and/or inhibit memory T-cell subsets and functions that can lead to immunopathology.
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
authors.forename: David
authors.initials: D
authors.lastname: Verhoeven
authors.forename: John R
authors.initials: JR
authors.lastname: Teijaro
authors.forename: Donna L
authors.initials: DL
authors.lastname: Farber
mesh_terms: D000818:Animals; D006801:Humans; D007156:Immunologic Memory; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology* / Q000473:pathology*; D014780:Viruses / Q000276:immunology