title: Palladium-catalyzed beta-allylation of 2,3-disubstituted indoles.
abstract: Given the prevalence of the indole nucleus in biologically active compounds, the direct C3-functionalization of 2,3-disubstituted indoles represents an important problem. Described is a general, high-yielding method for the palladium-catalyzed beta-allylation of carba- and heterocycle fused indoles, including complex natural product substrates.
authors.affiliation: Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Natsuko
authors.initials: N
authors.lastname: Kagawa
authors.forename: Jeremiah P
authors.initials: JP
authors.lastname: Malerich
authors.forename: Viresh H
authors.initials: VH
authors.lastname: Rawal
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry; D002227:Carbazoles / Q000737:chemistry; D002243:Carbolines / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D002227:Carbazoles; D002243:Carbolines; D007211:Indoles; D010165:Palladium