title: Comparison of AlloDerm, fat, fascia, cartilage, and dermal grafts in rabbits.
abstract: OBJECTIVE
  To compare various graft materials in the rabbit model, including autologous cartilage, dermal tissue, fat, and AlloDerm (a cadaver-derived material).
  
  
  METHODS
  Twenty-five New Zealand white rabbits were used. Equally sized autogenous (fat, fascia, cartilage, and dermal) grafts and AlloDerm were implanted into subcutaneous dorsal pockets on the rabbits. Animals were killed 1, 2, 3, and 4 months after surgery. The grafts were examined microscopically for thickness, resorption, fibrosis, neovascularization, inflammation, eosinophilia, and the presence of multinucleated giant cells or microcysts.
  
  
  RESULTS
  The cartilage grafts revealed excellent viability with no resorption. The fascial grafts showed negligible volume loss. The dermal grafts developed epidermoid cysts. The AlloDerm grafts demonstrated graft thickening at 1 month and total resorption at 3 and 4 months. The fat grafts demonstrated 30% to 60% partial resorption.
  
  
  CONCLUSIONS
  The major disadvantage of using an autogenous fat graft was partial resorption, whereas cyst formation was observed with dermal grafts. AlloDerm caused tissue reaction and resorption. The best graft material was cartilage, with a low absorption rate, good biocompatibility, and minimal tissue reaction or fibrosis, followed by fascia, with a minimal shrinkage capacity and tissue reaction.
authors.affiliation: Department of Otorhinolaryngology, Baskent University Faculty of Medicine, Ankara, Turkey. erkantarhan@gmail.com
authors.forename: Erkan
authors.initials: E
authors.lastname: Tarhan
authors.forename: Ozcan
authors.initials: O
authors.lastname: Cakmak
authors.forename: Binnaz Handan
authors.initials: BH
authors.lastname: Ozdemir
authors.forename: Volkan
authors.initials: V
authors.lastname: Akdogan
authors.forename: Dinc
authors.initials: D
authors.lastname: Suren
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000818:Animals; D002356:Cartilage / Q000637:transplantation*; D003094:Collagen / Q000627:therapeutic use*; D020405:Dermis / Q000637:transplantation*; D004804:Eosinophils / Q000378:metabolism; D005205:Fascia / Q000637:transplantation*; D011817:Rabbits; D012867:Skin / Q000166:cytology / Q000378:metabolism
chemical_list: C440568:Alloderm; D003094:Collagen