Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques: influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV(89.6P) infection.
Protection afforded by HIV Tat-based vaccines has differed in Indian rhesus and Mauritian cynomolgus macaques. We evaluated native Tat and Ad-HIVtat priming/Tat-boosting regimens in both species. Both vaccines were immunogenic. Only the Ad-tat regimen modestly reduced acute viremia in rhesus macaques after SHIV(89.6P) challenge. Confounding variables uncovered in Mauritian macaques included significant associations of susceptibility to infection with MHC class IB and class II H2 and H5 haplotypes, and resistance to infection with class IB haplotypes H3 and H6. Although protection here was limited, Tat-based vaccines incorporating other HIV components have shown greater efficacy. Combination strategies should be further explored.
Florese
Ruth H
RH
Vaccine Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Wiseman
Roger W
RW
Venzon
David
D
Karl
Julie A
JA
Demberg
Thorsten
T
Larsen
Kay
K
Flanary
Leon
L
Kalyanaraman
V S
VS
Pal
Ranajit
R
Titti
Fausto
F
Patterson
L Jean
LJ
Heath
Megan J
MJ
O'Connor
David H
DH
Cafaro
Aurelio
A
Ensoli
Barbara
B
Robert-Guroff
Marjorie
M
D016915:AIDS Vaccines / Q000276:immunology*; D000818:Animals; D004198:Disease Susceptibility; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D019562:Viral Load; D014766:Viremia; D054322:tat Gene Products, Human Immunodeficiency Virus / Q000276:immunology*
D016915:AIDS Vaccines; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D054322:tat Gene Products, Human Immunodeficiency Virus