An event-related fMRI study on risk taking by healthy individuals of high or low impulsiveness.
This event-related functional Magnetic Resonance Imaging study examined the differential neural activities associated with a Risky-Gains task in 18 healthy individuals of high (n=9) or low (n=9) impulsiveness, according to their scores on the Barratt Impulsiveness Scale (BIS). The neural activities of people belonging to the high and low impulsiveness groups were monitored by a 3T MRI scanner while they were performing the Risky-Gains task. We demonstrated that a stronger activation in the insula-orbitofrontal-parietal regions was found in the high impulsiveness group compared to the low impulsiveness group. However, the levels of activation in the lateral prefrontal and anterior cingulate regions did not differ between the two groups. The findings suggest that the neural substrates of comprehension of cognitive and affective information associated with risk-taking decision making may vary according to the impulsiveness among healthy individuals.
Lee
Tatia M C
TM
Laboratory of Neuropsychology, The University of Hong Kong, Hong Kong, China.
Chan
Chetwyn C H
CC
Han
Shi-hui
SH
Leung
Ada W S
AW
Fox
Peter T
PT
Gao
Jia-Hong
JH
D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006179:Gyrus Cinguli / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D007175:Impulsive Behavior; D008032:Limbic System / Q000033:anatomy & histology / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012309:Risk-Taking