A comparison of biological activities of a new soya biopeptide studied in an in vitro skin equivalent model and human volunteers.
During aging, the epidermis and dermis become thin and an efficient anti-aging product should be able to stimulate the metabolism of senescent fibroblast and keratinocytes, in order to increase the quantity of extra-cellular matrix components such as collagen and glycosaminoglycans. A study performed in parallel on an in vitro skin equivalent model, and in vivo, with human volunteers, demonstrated the efficacy of one specific soya biopeptide for anti-aging properties. Such a biopeptide induces a significant increase of glycosaminoglycans synthesis in vitro and in vivo after a one-month treatment. We also showed that this new cosmetic ingredient is able to stimulate favourably the collagen synthesis in vitro and in vivo. This study provided the proof for anti-aging properties of a new soya biopeptide and also validated the skin equivalent model developed for this experimentation as an alternative method to animal or human testing for some cosmetic efficacy evaluations.
Andre-Frei
V
V
Henkel KGaA Henkelstrasse 67, POB 1100, 40191 Düsseldorf, Germany.
Perrier
E
E
Augustin
C
C
Damour
O
O
Bordat
P
P
Schumann
K
K
Förster
T
T
Waldmann-Laue
M
M