Ah receptor agonist activity in frequently consumed food items.
The aryl hydrocarbon receptor (AhR) receives much attention for its role in the toxicity of dioxins and dioxin-like polychlorinated biphenyls. However, many other compounds have also been reported to bind and activate AhR, of which natural food components are of special interest from a human health perspective. Using the dioxin receptor-chemical-activated luciferase gene expression (DR CALUX) bioassay, extracts from many food items frequently consumed in the Netherlands were screened to estimate the intake of natural AhR agonists (NAhRAs). Using the prototypical AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as standard, it was estimated that the daily intake of NAhRAs might be considerably higher than the reported intake of dioxins and dioxin-like polychlorinated biphenyls. Potatoes, cruciferous vegetables, bread, hamburgers, and grapefruit juice contained most NAhRAs. Food preparation and acid treatment can show a significant effect on AhR activation. The interaction of natural and xenobiotic AhR agonists should be taken into account when performing risk-benefit analysis of both types of compounds.
De Waard
W J
WJ
RIVM, Safety Medicines and Teratology, Bilthoven, The Netherlands.
Aarts
J M M J G
JM
Peijnenburg
A C M
AC
De Kok
T M C M
TM
Van Schooten
F-J
FJ
Hoogenboom
L A P
LA
D000818:Animals; D001681:Biological Assay / Q000379:methods; D004785:Environmental Pollutants / Q000032:analysis; D005247:Feeding Behavior; D005504:Food Analysis / Q000379:methods; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D000072317:Polychlorinated Dibenzodioxins / Q000032:analysis*; D051381:Rats; D018336:Receptors, Aryl Hydrocarbon / Q000819:agonists*; D014407:Tumor Cells, Cultured; D014675:Vegetables / Q000737:chemistry
D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon