Fluorous Mixture Synthesis (FMS) of Enantiomers, Diastereomers, and Compound Libraries.
Fluorous mixture synthesis (FMS) is a newly developed highly-efficient solution-phase technology. A set of substrates attached to homologous fluorous tags is mixed and taken through a sequence of organic reactions. The final mixtures are demixed by fluorous HPLC and detagged to give individually pure final products. Applications of FMS for the preparation of 2 enantiomers of pyridovericin, 16 diastereomers of murisolin, and a 560-member mappicine library are highlighted in this article.
Zhang
Wei
W
Fluorous Technologies, Inc. University of Pittsburgh Applied Research Center, 970 William Pitt Way Pittsburgh, PA 15238, USA E-Mail: w.zhang@fluorous.com.