Sickle red cell adhesion: many issues and some answers.
Among multiple pathologies associated with sickle cell disease, sickle red cell-endothelial interaction has been implicated as a potential initiating mechanism in vaso-occlusive events that characterize this disease. Vast literature exists on various aspects of sickle red cell adhesion, but many issues remain unresolved, especially pertaining to the role of sickle red cell heterogeneity, the relative role of multiple adhesion mechanisms and targets of antiadhesive therapy. This review briefly analyzes these issues.
Kaul
D K
DK
Department of medicine, Ullmann 917, Albert Einstein College of Medicine, 1300 Morris Park avenue, Bronx, NY 10461, USA. kaul@aecom.yu.edu
D000755:Anemia, Sickle Cell / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D002448:Cell Adhesion / Q000502:physiology*; D004912:Erythrocytes / Q000502:physiology*; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000502:physiology
D039302:Integrin alphaVbeta3