Combined effect of gender and caloric restriction on liver proteomic expression profile.
We analyzed the combined effect of gender and CR on protein expression profile in liver. We identified 27 differentially expressed proteins involved in several cellular functions such as substrate metabolism, antioxidant systems, stress response, iron homeostasis and cardiovascular protection. This study reveals new cellular pathways liable to be similarly regulated in females and calorie restricted rats and which could be related with the greater longevity in these animals.
Valle
Adamo
A
Grup de Metabolisme Energetic i Nutricio, Departament de Biologia Fonamental i Ciencies de la Salut, Institut Universitari d'Investigacio en Ciencies de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain. vdbsavg4@uib.es
Silvestri
Elena
E
Moreno
Maria
M
Chambery
Angela
A
Oliver
Jordi
J
Roca
Pilar
P
Goglia
Fernando
F
D000818:Animals; D001835:Body Weight; D031204:Caloric Restriction; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D020869:Gene Expression Profiling; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism*; D008136:Longevity; D008297:Male; D009929:Organ Size; D020543:Proteome / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D020543:Proteome