Synthesis and Analgesic Activity of eta-(Anisole)- Triscarbonyl-Chromium(0).
The general method for synthesis the eta(6)-(arene)-triscarbonyl-chromium(0) complexes was modified and applied for preparation of eta(6)-(anisole)-triscarbonyl-chromium(0) and the study of its analgesic activity was undertaken. A significant analgesic activity was observed after intraperitoneal injection, in Wistar rats. Two doses (30 and 50 mg/Kg of the body weight) of eta(6)-(anisole)- triscarbonyl-chromium(0) were injected and the analgesic activity was evaluated by the Hot Plate Test method. They showed a significant analgesic effect in comparison with the control group and the group treated with dipyrone standard, but not so high when compared with the group treated with morphine standard. Overall, it was observed that the eta(6)-(anisole)- triscarbonyl-chromium(0) was easily obtained by the modified synthetic method and was effective in increasing the pain threshold.
Andrade E Silva
M L
ML
Universidade de Franca Dept. of Chemistry Avenida Dr. Armando Salles Oliveira 201, Campus Franca SP 14404-600 Brazil.
Neto
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AF
Miller
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