title: Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction.
abstract: BACKGROUND
  This study was designed to investigate the association of the 894G>T polymorphism in the eNOS gene with risk of acute myocardial infarction (AMI), extent of coronary artery disease (CAD) on coronary angiography, and in-hospital mortality after AMI.
  
  
  METHODS
  We studied 1602 consecutive patients who were enrolled in the GEMIG study. The control group was comprised by 727 individuals, who were randomly selected from the general adult population.
  
  
  RESULTS
  The prevalence of the Asp298 variant of eNOS was not found to be significantly and independently associated with risk of AMI (RR = 1.08, 95%CI = 0.77-1.51, P = 0.663), extent of CAD on angiography (OR = 1.18, 95%CI = 0.63-2.23, P = 0.605) and in-hospital mortality (RR = 1.08, 95%CI = 0.29-4.04, P = 0.908).
  
  
  CONCLUSIONS
  In contrast to previous reports, homozygosity for the Asp298 variant of the 894G>T polymorphism in the eNOS gene was not found to be associated with risk of AMI, extent of CAD and in-hospital mortality after AMI.
authors.affiliation: 1st Cardiac Department, Evaggelismos Hospital, Athens, Greece. gkandrik@otenet.gr
authors.forename: George K
authors.initials: GK
authors.lastname: Andrikopoulos
authors.forename: Dimitris K
authors.initials: DK
authors.lastname: Grammatopoulos
authors.forename: Stylianos E
authors.initials: SE
authors.lastname: Tzeis
authors.forename: Sevasti I
authors.initials: SI
authors.lastname: Zervou
authors.forename: Dimitris J
authors.initials: DJ
authors.lastname: Richter
authors.forename: Michalis N
authors.initials: MN
authors.lastname: Zairis
authors.forename: Elias J
authors.initials: EJ
authors.lastname: Gialafos
authors.forename: Dimitris C
authors.initials: DC
authors.lastname: Sakellariou
authors.forename: Stefanos G
authors.initials: SG
authors.lastname: Foussas
authors.forename: Antonis S
authors.initials: AS
authors.lastname: Manolis
authors.forename: Christodoulos I
authors.initials: CI
authors.lastname: Stefanadis
authors.forename: Pavlos K
authors.initials: PK
authors.lastname: Toutouzas
authors.forename: Edward W
authors.initials: EW
authors.lastname: Hillhouse
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000201:enzymology / Q000209:etiology / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D005091:Exons; D005260:Female; D006115:Greece / Q000453:epidemiology; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology* / Q000209:etiology / Q000235:genetics* / Q000401:mortality; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D017931:DNA Primers; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III