title: Chemical site-selective prenylation of proteins.
abstract: A direct thionation procedure allows conversion of allylic alcohols into the corresponding thiols, the products of which are immediately compatible with one-pot site-selective selenenyl sulfide mediated protein conjugation.
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, UK.
authors.forename: David P
authors.initials: DP
authors.lastname: Gamblin
authors.forename: Sander
authors.initials: S
authors.lastname: van Kasteren
authors.forename: Gonçalo J L
authors.initials: GJ
authors.lastname: Bernardes
authors.forename: Justin M
authors.initials: JM
authors.lastname: Chalker
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Oldham
authors.forename: Antony J
authors.initials: AJ
authors.lastname: Fairbanks
authors.forename: Benjamin G
authors.initials: BG
authors.lastname: Davis
mesh_terms: D001407:Bacillus / Q000201:enzymology; D001665:Binding Sites; D057927:Hydrophobic and Hydrophilic Interactions; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D017368:Protein Prenylation; D011994:Recombinant Proteins / Q000138:chemical synthesis / Q000737:chemistry; D018036:Selenium Compounds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D020860:Subtilisin / Q000138:chemical synthesis / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D020005:Propanols; D011994:Recombinant Proteins; D018036:Selenium Compounds; D013438:Sulfhydryl Compounds; C006463:allyl alcohol; D020860:Subtilisin