Bioactive marine prostanoids from octocoral Clavularia viridis.
Chemical investigation of the nonpolar extract of soft coral Clavularia viridis resulted in isolation of five new prostanoids, designated as claviridic acids A-E (1-5, resp.), in addition to the known clavulones I-III. Their structures were determined on the basis of spectroscopic techniques, especially HR-ESI-MS, CD, and 2D-NMR experiments. The isolated marine prostanoids exhibited potent inhibitory effect on PHA-induced proliferation of peripheral blood mononuclear cells (PBMC), as well as significant cytotoxic activity against human gastric cancer cells (AGS).
Lin
Yun-Sheng
YS
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China.
Khalil
Ashraf Taha
AT
Chiou
Shih-Hwa
SH
Kuo
Yuh-Chi
YC
Cheng
Yuan-Bin
YB
Liaw
Chia-Ching
CC
Shen
Ya-Ching
YC
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D049109:Cell Proliferation; D002478:Cells, Cultured; D006801:Humans; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011453:Prostaglandins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D011453:Prostaglandins