title: Aqueous extract of Anemarrhena rhizome increases cell proliferation and neuropeptide Y expression in the hippocampal dentate gyrus on streptozotocin-induced diabetic rats.
abstract: In this study, the effects of the aqueous extract of Anemarrhena rhizome on cell proliferation and neuropeptide Y expression in the dentate gyrus of streptozotocin-induced diabetic rats were investigated via immunohistochemistry for 5-bromo-2'-deoxyuridine (BrdU) and neuropeptide Y. The results showed that the treatment with 50 to 200 microg/kg/day for 7 days of the aqueous extract of Anemarrhena rhizome increased new cell formation and neuropeptide Y expression in the dentate gyrus of diabetic rats reduced by the treatment with streptozotocin in rat.
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea. malsoon@khu.ac.kr
authors.forename: Mal-Soon
authors.initials: MS
authors.lastname: Shin
authors.forename: Su-Kyung
authors.initials: SK
authors.lastname: Kim
authors.forename: Youn-Sub
authors.initials: YS
authors.lastname: Kim
authors.forename: Sung-Eun
authors.initials: SE
authors.lastname: Kim
authors.forename: Il-Gyu
authors.initials: IG
authors.lastname: Ko
authors.forename: Young-Sick
authors.initials: YS
authors.lastname: Kim
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
authors.forename: You-Mi
authors.initials: YM
authors.lastname: Kim
authors.forename: Bo-Kyun
authors.initials: BK
authors.lastname: Kim
authors.forename: Tae-Soo
authors.initials: TS
authors.lastname: Kim
mesh_terms: D031403:Anemarrhena / Q000737:chemistry*; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D018891:Dentate Gyrus / Q000166:cytology / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental; D005786:Gene Expression Regulation / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D009478:Neuropeptide Y / Q000235:genetics / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome / Q000737:chemistry*; D013311:Streptozocin
chemical_list: D007004:Hypoglycemic Agents; D009478:Neuropeptide Y; D010936:Plant Extracts; D013311:Streptozocin