Mucinous changes in melanocytic nevi and review of the literature.
Mucin deposition is seen in the stroma of a variety of cutaneous neoplasms. Although reported, it is uncommon in melanocytic tumors. Observation of abundant mucin in the stroma of some cases of melanocytic nevi prompted us to review all cases of dermal and compound nevi in a 6-month period. We found that dermal nevi had a higher incidence of mucin in the stroma than compound nevi (2.75% vs 0.55%). The mucin was seen both in stroma and within the nests of nevus cells. The cause and significance of mucin deposition are not known.
Perdiki
Marina
M
Department of Pathology, Karolinska Hospital, Stockholm, Sweden.
Bhawan
Jag
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism*; D009508:Nevus, Pigmented / Q000378:metabolism / Q000473:pathology*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D013194:Staining and Labeling; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology
D014408:Biomarkers, Tumor; D009077:Mucins