title: Bortezomib in multiple myeloma.
abstract: BACKGROUND
  Bortezomib is a novel, first-in-class proteasome inhibitor that has improved outcomes in multiple myeloma, with manageable toxicities.
  
  
  OBJECTIVE
  To summarise the chemistry, pharmacokinetics and metabolism of bortezomib, and review its clinical efficacy and toxicity, including use in elderly patients, use in patients with renal impairment and/or a poor prognosis, and effects on bone metabolism.
  
  
  METHODS
  Literature search of bortezomib studies (within 10 years) and recent congress abstracts.
  
  
  CONCLUSIONS
  Bortezomib has improved response rates, overall survival, and time to progression in relapsed or refractory disease, both as a single agent and as part of combination regimens. Promising results have also been reported with bortezomib combinations in frontline induction therapy. Patient subgroups where conventional approaches are inappropriate may also benefit, thereby expanding the therapeutic armamentarium against this debilitating disease.
authors.affiliation: General Air Force Hospital, Department of Haematology & Medical Research, 3 Kanellopoulou Street, GR-11525, Athens, Greece. e.terpos@imperial.ac.uk
authors.forename: Evangelos
authors.initials: E
authors.lastname: Terpos
authors.forename: Maria
authors.initials: M
authors.lastname: Roussou
authors.forename: Meletios-Athanassios
authors.initials: MA
authors.lastname: Dimopoulos
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001897:Boronic Acids / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D000069286:Bortezomib; D002986:Clinical Trials as Topic; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D006801:Humans; D009101:Multiple Myeloma / Q000188:drug therapy*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D011719:Pyrazines / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib