Chronic actinic dermatitis in a patient with adult T-cell leukemia.
A patient with chronic actinic dermatitis showed a leukocytosis with peripheral atypical lymphocytes. Histology of cutaneous eruptions disclosed a dense infiltrate of lymphocytes mixed with large hyperchromatic cells in the dermis and Pautrier-like microabscesses in the epidermis. However, clonal rearrangements of the T-cell receptors were not detected. On the other hand, monoclonal integration of human T-cell lymphotrophic virus type I provirus was found in the peripheral lymphocytes. In the present case, pseudolymphomatous changes occurred in association with adult T-cell leukemia. Southern blot analyses were useful for the correct diagnosis.
Adachi
Yuka
Y
Department of Dermatology, Kansai Medical University, Osaka, Japan.
Horio
Takeshi
T
D000368:Aged; D015139:Blotting, Southern; D004279:DNA, Viral / Q000032:analysis; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000175:diagnosis; D008214:Lymphocytes / Q000473:pathology / Q000821:virology; D008297:Male; D010787:Photosensitivity Disorders / Q000150:complications* / Q000175:diagnosis; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000175:diagnosis; D014466:Ultraviolet Rays
D004279:DNA, Viral; D011948:Receptors, Antigen, T-Cell