Neural coding of stimulus concentration in the human olfactory and intranasal trigeminal systems.
Nasal chemical sensations are mediated principally by the olfactory and the trigeminal systems. Over the last few years brain structures involved in processing of trigeminal stimuli have been more and more documented. However, the exact role of individual regions in stimulus intensity processing is unclear. The present study set out to examine the neural network involved in encoding stimulus intensity in the trigeminal system and the olfactory system of humans. Participants were presented with two concentrations of relatively specific trigeminal stimuli (CO2) and olfactory (H2S), respectively. Responses were assessed by functional magnetic resonance imaging (fMRI). Whereas brain responses to stimulus intensity in the olfactory modality involved a wide neural network including cerebellum, entorhinal cortex, visual areas, and frontal regions, contrasting high and low CO2 concentrations revealed activation in a less complex network including various sub-regions of the cingulate cortex. Taken together, these results suggest separate but overlapping neural networks involved in encoding stimulus intensity in the two chemosensory systems.
Bensafi
M
M
Université Claude Bernard, Lyon, Laboratoire de Neurosciences Sensorielles, Comportement, Cognition, UMR 5020, Institut Fédératif des Neurosciences de Lyon, IFR19, CNRS, Lyon, France. bensafi@olfac.univ-lyon1.fr
Iannilli
E
E
Gerber
J
J
Hummel
T
T
D000328:Adult; D002245:Carbon Dioxide; D002540:Cerebral Cortex / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006862:Hydrogen Sulfide; D008279:Magnetic Resonance Imaging; D009415:Nerve Net / Q000502:physiology; D009666:Nose / Q000294:innervation* / Q000502:physiology*; D009812:Odorants; D009833:Olfactory Pathways / Q000502:physiology*; D014276:Trigeminal Nerve / Q000502:physiology*
D002245:Carbon Dioxide; D006862:Hydrogen Sulfide