title: Cost of increasing access to artemisinin combination therapy: the Cambodian experience.
abstract: BACKGROUND
  Malaria-endemic countries are switching antimalarial drug policy from cheap ineffective monotherapies to artemisinin combination therapies (ACTs) for the treatment of Plasmodium falciparum malaria and the global community are considering setting up a global subsidy to fund their purchase. However, in order to ensure that ACTs are correctly used and are accessible to the poor and remote communities who need them, specific interventions will be necessary and the additional costs need to be considered.
  
  
  METHODS
  This paper presents an incremental cost analysis of some of these interventions in Cambodia, the first country to change national antimalarial drug policy to an ACT of artesunate and mefloquine. These costs include the cost of rapid diagnostic tests (RDTs), the cost of blister-packaging the drugs locally and the costs of increasing access to diagnosis and treatment to remote communities through malaria outreach teams (MOTs) and Village Malaria Workers (VMW).
  
  
  RESULTS
  At optimum productive capacity, the cost of blister-packaging cost under $0.20 per package but in reality was significantly more than this because of the low rate of production. The annual fixed cost (exclusive of RDTs and drugs) per capita of the MOT and VMW schemes was $0.44 and $0.69 respectively. However because the VMW scheme achieved a higher rate of coverage than the MOT scheme, the cost per patient treated was substantially lower at $5.14 compared to $12.74 per falciparum malaria patient treated. The annual cost inclusive of the RDTs and drugs was $19.31 for the MOT scheme and $11.28 for the VMW scheme given similar RDT positivity rates of around 22% and good provider compliance to test results.
  
  
  CONCLUSIONS
  In addition to the cost of ACTs themselves, substantial additional investments are required in order to ensure that they reach the targeted population via appropriate delivery systems and to ensure that they are used appropriately. In addition, differences in local conditions, in particular the prevalence of malaria and the pre-existing infrastructure, need to be considered in choosing appropriate diagnostic and delivery strategies.
authors.affiliation: Health Policy Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. shunmay.yeung@lshtm.ac.uk
authors.forename: Shunmay
authors.initials: S
authors.lastname: Yeung
authors.forename: Wim
authors.initials: W
authors.lastname: Van Damme
authors.forename: Duong
authors.initials: D
authors.lastname: Socheat
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
authors.forename: Anne
authors.initials: A
authors.lastname: Mills
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000191:economics* / Q000627:therapeutic use*; D037621:Artemisinins / Q000191:economics* / Q000627:therapeutic use*; D002160:Cambodia / Q000453:epidemiology; D003365:Costs and Cost Analysis; D004359:Drug Therapy, Combination; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000191:economics* / Q000453:epidemiology; D015767:Mefloquine / Q000627:therapeutic use
chemical_list: D000962:Antimalarials; D037621:Artemisinins; C031327:artemisinin; D015767:Mefloquine