Arterial smooth muscle cells dysfunction in hyperglycaemia and hyperglycaemia associated with hyperlipidaemia: from causes to effects.
Given the important role of smooth muscle cells in arterial wall dysfunction in diabetes, as well as in diabetes associated with accelerated atherosclerosis, we provide a brief review of the recent achievements in identification of signalling molecules underlying their altered cellular responses, and examine the consequences of these pathological insults on smooth muscle cells properties. The original results emerging from the Golden Syrian hamster model (rendered diabetic or simultaneously hyperlipidaemic-diabetic) and from human aortic smooth muscle cells cultured in 25 mM glucose (to mimic diabetic condition) or sera of obese type 2 diabetic patients (to mimic the metabolic syndrome condition) are presented in this context. We conclude this review with several open issues disclosed by the most recent literature that deserve essential attention for targeting the translational medicine.
Popov
Doina
D
Institute of Cellular Biology and Pathology N. Simionescu, 8 B.P. Hasdeu Street, Bucharest, Romania. doina.popov@icbp.ro
Constantinescu
Elena
E
D000818:Animals; D001158:Arteries / Q000503:physiopathology*; D001786:Blood Glucose / Q000032:analysis; D006224:Cricetinae; D006943:Hyperglycemia / Q000150:complications / Q000503:physiopathology*; D006949:Hyperlipidemias / Q000150:complications / Q000503:physiopathology*; D008647:Mesocricetus; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*
D001786:Blood Glucose