title: Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO(5): At Least Three Independent Reaction Pathways.
abstract: In order to better define the mechanism and the products of guanine oxidation within DNA, we investigated the details of the mechanism of guanine oxidation by a metalloporphyrin, Mn-TMPyP, associated to KHSO(5) on oligonucleotides. We found that the three major products of guanine oxidation are formed by independent reaction routes. The oxidized guanidinohydantoin (1) and the proposed spiro compound 3 derivatives are not precursors of imidazolone lesion (Iz). These guanine lesions as well as their degradation products, may account for non-detected guanine oxidation products on oxidatively damaged DNA.
authors.affiliation: Laboratoire de Chimie de Coordination du CNRS 205 route de Narbonne Toulouse Cedex 4 F-31077 France.
authors.forename: A
authors.initials: A
authors.lastname: Lapi
authors.forename: G
authors.initials: G
authors.lastname: Pratviel
authors.forename: B
authors.initials: B
authors.lastname: Meunier