title: Alcohol produces imbalance of adrenal and neuronal sympathetic activity in patients with alcohol-induced neurocardiogenic syncope.
abstract: BACKGROUND
  The mechanism of alcohol-induced syncope is unknown.
  
  
  RESULTS
  Head-up tilt tests (HUT: upright at 80 degrees for 30 min) were performed before and after alcohol consumption in 25 patients with unexplained syncope after drinking alcohol. Plasma levels of epinephrine (P-E) and norepinephrine (P-NE) were measured in a supine position and during HUT (at 15 min). Before drinking alcohol, HUT did not provoke neurocardiogenic syncope (NCS) in any of the 25 patients. After drinking alcohol, HUT provoked NCS in 11 patients (alcohol-positive or AP group) but not in 14 patients (alcohol-negative or AN group). Prior to alcohol consumption, P-E and P-NE increased during HUT in both groups, and did not differ significantly between the 2 groups. After alcohol consumption, P-E and P-NE increased during HUT in both group. During HUT, P-NE did not differ between the 2 groups, but P-E was significantly higher in the AP group than in the AN group during HUT (258.0+/-179.2 vs 70.9+/-35.1 pg/ml, p<0.05).
  
  
  CONCLUSIONS
  These results suggest that an imbalance in the increases of adrenomedullar sympathetic nerve activity (as expressed by the P-E level) and peripheral sympathetic nerve activity (as expressed by the P-NE level) both induced by alcohol, may play a crucial role in alcohol-induced NCS.
authors.affiliation: Department of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Takahashi
authors.forename: Shinobu
authors.initials: S
authors.lastname: Imai
authors.forename: Fumio
authors.initials: F
authors.lastname: Saito
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Suzuki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Toshio
authors.initials: T
authors.lastname: Kushiro
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yagi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hirayama
mesh_terms: D000313:Adrenal Medulla / Q000502:physiology*; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D001127:Arginine Vasopressin / Q000097:blood; D001794:Blood Pressure; D004837:Epinephrine / Q000097:blood; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D012083:Renin / Q000097:blood; D016683:Supine Position; D013564:Sympathetic Nervous System / Q000502:physiology*; D019462:Syncope, Vasovagal / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D018667:Tilt-Table Test
chemical_list: D001127:Arginine Vasopressin; D012083:Renin; D009638:Norepinephrine; D004837:Epinephrine