title: [Like anticataract agents, the antiaggregants of lens crystallin. Communication 2. Study of the impact of chaperon-like (protective) activity of short-chain peptides on the rate of UV-induced aggregation of betaL-crystallins by eximer laser].
abstract: UV-induced aggregation of betaL-crystallin, one of the major lens proteins, was studied under its pulse radiation with XeCl laser at a wavelength of 308 nm. Unlike the in vitro tested dipeptides L-carnosine, N-acetyl carnosine, D-panthetine, and particularly their combination, the so-called new chaperon was demonstrated to slow down the rate of photoaggregatin of beta-crystallin. The new chaperon, a mixture of D-pathethine and N-acetyl carnosine was ascertained to protect a mixture of betaL- and alpha-crystallins from UV-induced aggregation to a greater extent than D-pathethine or N-acetyl carnosine used alone. An effective drug based on the new chaperon may be designed for the prevention of cataract in sight.
authors.forename: L V
authors.initials: LV
authors.lastname: Soustov
authors.forename: E V
authors.initials: EV
authors.lastname: Chelnokov
authors.forename: N V
authors.initials: NV
authors.lastname: Sapogova
authors.forename: N M
authors.initials: NM
authors.lastname: Bitiurin
authors.forename: V V
authors.initials: VV
authors.lastname: Nemov
authors.forename: O E
authors.initials: OE
authors.lastname: Karpova
authors.forename: N L
authors.initials: NL
authors.lastname: Sheremet
authors.forename: G S
authors.initials: GS
authors.lastname: Polunin
authors.forename: S E
authors.initials: SE
authors.lastname: Avetisov
authors.forename: M A
authors.initials: MA
authors.lastname: Ostrovskiĭ
mesh_terms: D002336:Carnosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002386:Cataract / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004359:Drug Therapy, Combination; D006801:Humans; D054018:Lasers, Excimer / Q000009:adverse effects*; D007908:Lens, Crystalline / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D018832:Molecular Chaperones / Q000627:therapeutic use*; D014466:Ultraviolet Rays / Q000009:adverse effects*; D038204:beta-Crystallins / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects
chemical_list: D018832:Molecular Chaperones; D038204:beta-Crystallins; C033681:N-acetylcarnosine; D002336:Carnosine