title: Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029.
abstract: Five new preussomerin analogues, ymf 1029A (1), B (2), C (3), D (4), and E (5), were isolated from the liquid cultures of an unidentified freshwater fungus YMF 1.01029, along with four known compounds, preussomerin C (6), preussomerin D (7), (4RS)-4,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one (8), and 4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one (9). The structures of new metabolites were determined by analysis of NMR and MS data and by analogy with the data for the known bis-spirobisnaphthalene preussomerins. In vitro immersion experiments showed that these metabolites displayed weak nematicidal activity against Bursaphelenchus xylophilus, while compound 7 was the most potent. This is the first report of these compounds, which antagonize the Bursaphelenchus xylophilus nematode.
authors.affiliation: Laboratory for ConserVation and Utilization of Bio-Resources, Yunnan University, Kunming 650091, People's Republic of China.
authors.forename: Jin Yan
authors.initials: JY
authors.lastname: Dong
authors.forename: Hong Chuan
authors.initials: HC
authors.lastname: Song
authors.forename: Jian Hua
authors.initials: JH
authors.lastname: Li
authors.forename: Yu Shu
authors.initials: YS
authors.lastname: Tang
authors.forename: Rong
authors.initials: R
authors.lastname: Sun
authors.forename: Le
authors.initials: L
authors.lastname: Wang
authors.forename: Yong Ping
authors.initials: YP
authors.lastname: Zhou
authors.forename: Li Mei
authors.initials: LM
authors.lastname: Wang
authors.forename: Kai Ze
authors.initials: KZ
authors.lastname: Shen
authors.forename: Chun Ren
authors.initials: CR
authors.lastname: Wang
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005618:Fresh Water / Q000382:microbiology; D005658:Fungi / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007559:Ivermectin / Q000031:analogs & derivatives / Q000494:pharmacology; D015394:Molecular Structure; D009348:Nematoda / Q000187:drug effects; D014197:Trees / Q000382:microbiology
chemical_list: D000969:Antinematodal Agents; D004852:Epoxy Compounds; D006576:Heterocyclic Compounds, 4 or More Rings; C530777:Ymf 1029A; D007559:Ivermectin; C019264:avermectin