Methanol intoxication-induced nigrostriatal dysfunction detected using 6-[18F]fluoro-L-dopa PET.
Ingestion of windshield washer liquid resulted with an acute severe methanol intoxication in a 49-year old man. He developed optic atrophy with blindness, and an extrapyramidal syndrome. Putaminal injury and hyperintensity in the subcortical white matter was seen in a brain MRI. PET scanning with 6-[18F]fluoro-L-dopa confirmed symmetrical impaired presynaptic dopaminergic activity in the striatum, indicative of functional impairment of dopaminergic nigrostriatal neurons. The striatal uptake was more markedly impaired in the putamina (40% of controls) than in the caudate nuclei (60% of controls). To our knowledge, this is the first report of an 18F-dopa PET scanning result in a case of an acute methanol poisoning.
Airas
Laura
L
Department of Neurology, University of Turku, Turku, Finland. laura.airas@utu.fi
Paavilainen
Teemu
T
Marttila
Reijo J
RJ
Rinne
Juha
J
D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000473:pathology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007980:Levodopa; D008297:Male; D000432:Methanol / Q000633:toxicity*; D008875:Middle Aged; D011041:Poisoning / Q000150:complications*; D049268:Positron-Emission Tomography / Q000379:methods; D013378:Substantia Nigra / Q000000981:diagnostic imaging* / Q000473:pathology
D019788:Fluorodeoxyglucose F18; D007980:Levodopa; D000432:Methanol