title: Synthesis of spiro-bisperoxyketals.
abstract: Syntheses of spirocyclic bis-1,2-dioxolanes, bis-1,2-dioxanes, and bis-1,2-dioxepanes are achieved through intramolecular ketalizations of hydroperoxy ketones or intramolecular alkylations of gem-dihydroperoxides. The spiroperoxides have excellent thermal and chemical stability, and several display promising activity against P. falciparum.
authors.affiliation: Department of Chemistry and Nebraska Center for Materials and Nanoscience, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
authors.forename: Prasanta
authors.initials: P
authors.lastname: Ghorai
authors.forename: Patrick H
authors.initials: PH
authors.lastname: Dussault
authors.forename: Chunhua
authors.initials: C
authors.lastname: Hu
mesh_terms: D000080:Acetals / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D004146:Dioxanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000080:Acetals; D000962:Antimalarials; D004146:Dioxanes; D013141:Spiro Compounds