title: Effects of Organoantimony(III) Compounds of Sterically Hindered Bifunctional Tetradentate Ligands on the Reproductive System of Male Rats.
abstract: The antifertility activity of organoantimony(III) complexes PhSb[RC(NC(6)H(4)S)CH(2)(NC(6)H(4)S)CR'] {R' = CH(3) (R(1)) and R = R' = CF(3) (R(2))} derived from corresponding sterically hinlered bifuinctional tetradentate ligands in the male rats was determined. The administration of compounds R(1) and R(2) at the dose level of 20 mg/kg. b. wt. siignificantly reduced the weights of testes and epididymides. Auxiliary glands showed a significant reduction after the treatment of compound R(1) only. Treated animals showed a notable depression of spermatogenesis. The preleptotene spermatocytes were decreased by 76.19 and 47.06; the secondary spermatocytes by 87.4% and 54.87337; and the step-19 spermatids by 72.9 and 46.77% respectively, following the compound R(1) and R(2) treatment. Reduced sperm count and motility resulted in 100% negative fertility in both the treated groups. A significant fall in the content of various biochemical parameters of eproductive tissues was observed after R(1) and R(2) treatment in comparison to controls.
authors.affiliation: Department of Chemistry University of Rajasthan Jaipur 302 004 India.
authors.forename: R K
authors.initials: RK
authors.lastname: Sharma
authors.forename: M P
authors.initials: MP
authors.lastname: Dobhal
authors.forename: Y P
authors.initials: YP
authors.lastname: Singh
authors.forename: A K
authors.initials: AK
authors.lastname: Rai
authors.forename: R
authors.initials: R
authors.lastname: Sharma
authors.forename: R
authors.initials: R
authors.lastname: Chaudhary
authors.forename: R
authors.initials: R
authors.lastname: Yadav
authors.forename: R S
authors.initials: RS
authors.lastname: Gupta