title: Thailand mutation and variation database (ThaiMUT).
abstract: With the completion of the human genome project, novel sequencing and genotyping technologies had been utilized to detect mutations. Such mutations have continually been produced at exponential rate by researchers in various communities. Based on the population's mutation spectra, occurrences of Mendelian diseases are different across ethnic groups. A proportion of Mendelian diseases can be observed in some countries at higher rates than others. Recognizing the importance of mutation effects in Thailand, we established a National and Ethnic Mutation Database (NEMDB) for Thai people. This database, named Thailand Mutation and Variation database (ThaiMUT), offers a web-based access to genetic mutation and variation information in Thai population. This NEMDB initiative is an important informatics tool for both research and clinical purposes to retrieve and deposit human variation data. The mutation data cataloged in ThaiMUT database were derived from journal articles available in PubMed and local publications. In addition to collected mutation data, ThaiMUT also records genetic polymorphisms located in drug related genes. ThaiMUT could then provide useful information for clinical mutation screening services for Mendelian diseases and pharmacogenomic researches. ThaiMUT can be publicly accessed from http://gi.biotec.or.th/thaimut.
authors.affiliation: Biostatistics and Informatics Laboratory, Genome Institute, National Center for Genetic Engineering and Biotechnology (BIOTEC), Pathumtani, Thailand.
authors.forename: Uttapong
authors.initials: U
authors.lastname: Ruangrit
authors.forename: Metawee
authors.initials: M
authors.lastname: Srikummool
authors.forename: Anunchai
authors.initials: A
authors.lastname: Assawamakin
authors.forename: Chumpol
authors.initials: C
authors.lastname: Ngamphiw
authors.forename: Suparat
authors.initials: S
authors.lastname: Chuechote
authors.forename: Vilasinee
authors.initials: V
authors.lastname: Thaiprasarnsup
authors.forename: Gallissara
authors.initials: G
authors.lastname: Agavatpanitch
authors.forename: Ekawat
authors.initials: E
authors.lastname: Pasomsab
authors.forename: Pa-Thai
authors.initials: PT
authors.lastname: Yenchitsomanus
authors.forename: Surakameth
authors.initials: S
authors.lastname: Mahasirimongkol
authors.forename: Wasun
authors.initials: W
authors.lastname: Chantratita
authors.forename: Prasit
authors.initials: P
authors.lastname: Palittapongarnpim
authors.forename: Bunyarit
authors.initials: B
authors.lastname: Uyyanonvara
authors.forename: Chanin
authors.initials: C
authors.lastname: Limwongse
authors.forename: Sissades
authors.initials: S
authors.lastname: Tongsima
mesh_terms: D019295:Computational Biology / Q000379:methods; D004252:DNA Mutational Analysis; D030541:Databases, Genetic; D005796:Genes; D030342:Genetic Diseases, Inborn / Q000235:genetics; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D020407:Internet; D009154:Mutation; D011110:Polymorphism, Genetic; D013785:Thailand; D014584:User-Computer Interface