Testing replication of a 5-SNP set for general cognitive ability in six population samples.
A 5-single nucleotide polymorphism (SNP) set has been associated with general cognitive ability in 5000 7-year-old children from the Twins Early Development Study (TEDS). Four of these SNPs were identified through a 10 K microarray analysis and one was identified through a targeted analysis of brain-expressed genes. The present study tested this association with general cognitive ability in six population samples of varying size and age from Australia, the UK (Scotland and England) and the Netherlands. Results from the largest sample (N=1310) approached significance (P=0.06) in the direction of the original finding, but results from the other samples (N=205-758) were mixed. A meta-analysis of the results--allowing for effect size heterogeneity between samples--yielded a non-significant correlation (r=-0.01, P=0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied.
Luciano
Michelle
M
Department of Psychology, MRC Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. michelle.luciano@ed.ac.uk
Lind
Penelope A
PA
Deary
Ian J
IJ
Payton
Antony
A
Posthuma
Danielle
D
Butcher
Lee M
LM
Bochdanovits
Zoltan
Z
Whalley
Lawrence J
LJ
Visscher
Peter M
PM
Harris
Sarah E
SE
Polderman
Tinca J C
TJ
Davis
Oliver S P
OS
Wright
Margaret J
MJ
Starr
John M
JM
de Geus
Eco J C
EJ
Bates
Timothy C
TC
Montgomery
Grant W
GW
Boomsma
Dorret I
DI
Martin
Nicholas G
NG
Plomin
Robert
R
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003071:Cognition; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D020641:Polymorphism, Single Nucleotide; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic