title: Ileal pouch-anal anastomosis and liver transplantation for ulcerative colitis complicated by primary sclerosing cholangitis.
abstract: BACKGROUND
  The aim was to evaluate outcomes in patients with ulcerative colitis complicated by primary sclerosing cholangitis (PSC) who required ileal pouch-anal anastomosis (IPAA) and orthotopic liver transplantation (OLT).
  
  
  METHODS
  A retrospective analysis was performed of 32 patients undergoing both IPAA and OLT between 1980 and 2006. Data were collected regarding demographics, indication for surgery, postoperative complications, and outcome of IPAA and OLT.
  
  
  RESULTS
  Thirty-day mortality after either procedure was nil. The median preoperative Model for End-stage Liver Disease (MELD) score for the group with initial IPAA was 8 (range 6-20) and the postoperative score was 11 (range 6-19). At 1 and 10 years, 32 and 26 of the 32 liver grafts had survived, and 31 and 30 of the 32 pouches, respectively. Fourteen patients require daily medical therapy for chronic pouchitis. At a median follow-up of 3.6 (range 0.2-16.2) years after the second of two procedures, responding patients reported a median of 5.5 stools per day and 2 stools per night.
  
  
  CONCLUSIONS
  IPAA and OLT are feasible and safe in patients requiring both procedures for ulcerative colitis and PSC. Functional outcomes are stable over time, despite an increased risk of chronic pouchitis.
authors.affiliation: Mayo Clinic, Department of Surgery, Rochester, Minnesota 55905, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Mathis
authors.forename: E J
authors.initials: EJ
authors.lastname: Dozois
authors.forename: D W
authors.initials: DW
authors.lastname: Larson
authors.forename: R R
authors.initials: RR
authors.lastname: Cima
authors.forename: J M
authors.initials: JM
authors.lastname: Sarmiento
authors.forename: B G
authors.initials: BG
authors.lastname: Wolff
authors.forename: J K
authors.initials: JK
authors.lastname: Heimbach
authors.forename: J H
authors.initials: JH
authors.lastname: Pemberton
mesh_terms: D000293:Adolescent; D000328:Adult; D001003:Anal Canal / Q000601:surgery*; D000714:Anastomosis, Surgical; D015209:Cholangitis, Sclerosing / Q000150:complications*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000601:surgery; D039021:Colonic Pouches; D018572:Disease-Free Survival; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D019449:Pouchitis / Q000209:etiology; D016896:Treatment Outcome