Sentinel lymph node biopsy in breast cancer.
The clinical management of breast cancer has improved tremendously in the last 2 decades. Sentinel lymph node biopsy (SNB) allows conservation of the axillary lymph nodes in most patients who have breast cancer. Furthermore, it allows identification of occult nodal disease after step sectioning and more detailed staging. Although large breast tumors, multicentric disease, recurrent cancers, and use of neoadjuvant therapy were previously considered contraindications to SNB, a large body of evidence is accumulating to support its use in these cases. The prognostic significance of micrometastases and isolated tumor cells needs clarification in prospective, randomized trials.
Fortunato
Lucio
L
Department of Surgery, San Giovanni- Addolorata Hospital, Via Amba- Aradam 4, Rome 00184, Italy. lfortunato@tiscali.it
Mascaro
Alessandra
A
Amini
Mostafa
M
Farina
Massimo
M
Vitelli
Carlo Eugenio
CE
D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating; D006801:Humans; D007432:Intraoperative Period; D020360:Neoadjuvant Therapy; D009362:Neoplasm Metastasis; D011379:Prognosis; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*