[Expression of hypoxia inducible factor-1alpha and BNIP3 in human laryngeal carcinoma and their relationship].
OBJECTIVE
To investigate the expression of Hypoxia inducible factor-1alpha (HIF-1alpha)and the Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) in human laryngeal carcinoma and their relationship.


METHODS
The expression of HIF-1ALPHA and BNIP3 were detected by SP immunohistochemical method in 45 cases with laryngeal carcinoma tissues and 12 adjacent normal laryngeal tissue.


RESULTS
The expression of HIF-1alpha and BNIP3 were mainly in cytoplasm and nucleus. Their expression was higher in laryngeal tissue than in adjacent normal laryngeal tissue (P < 0.05). The expression of HIF 1alpha was positively related to that of BNIP3 in laryngeal carcinoma tissues (P < 0.05).


CONCLUSIONS
The high expression of HIF-1alpha and BNIP3 were closely related in laryngeal carcinomas, both of them played important role in the carcinogenesis and development of laryngeal carcinoma. HIF-1alpha might induce the expression of BNIP3. HIF-1alpha and BNIP3 might to be two potential therapeutic targets in laryngeal squamous, cell carcinomas.
Liu
Tao
T
Department of Otorhinolaryngology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China.
Ba
Yunpeng
Y
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*
C090121:BNIP3 protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins