Antimitochondrial antibody-negative primary biliary cirrhosis.
There is a subset of patients who have biochemical and histologic features consistent with primary biliary cirrhosis (PBC) who lack antimitochondrial antibodies (AMA). This entity is usually referred to as AMA-negative PBC or alternatively autoimmune cholangitis. Patients who have AMA-negative PBC are believed to have a similar clinical course, response to treatment, and prognosis as their AMA-positive counterparts. As more sensitive and specific serologic tests are developed to detect serum AMA, it is possible we may find that these patients initially believed to be AMA-negative are indeed AMA-positive, suggesting a single disease process.
Mendes
Flavia
F
Division of Hepatology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Lindor
Keith D
KD
D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000097:blood / Q000276:immunology* / Q000473:pathology
D001323:Autoantibodies