C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I.
Some dumbbell-shaped circular oligonucleotides containing internal C3-spacers and Topo I-binding sites were designed and synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as resisted the degradation by some DNA repair enzymes.
Wang
Yifan
Y
Department of Chemistry, 3 Science Drive 3, National University of Singapore, Singapore 117543, Singapore.
Ng
Magdeline Tao Tao
MT
Zhou
Tianyan
T
Li
Xinming
X
Tan
Choon Hong
CH
Li
Tianhu
T
D001483:Base Sequence; D001665:Binding Sites; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors
D004791:Enzyme Inhibitors; D009841:Oligonucleotides; D059004:Topoisomerase I Inhibitors