The three nucleotide deletion within the 3'untranslated region of MLH1 resulting in gene expression reduction is not a causal alteration in Lynch syndrome.
Tinat
J
J
Inserm U614, Faculty of Medicine and Department of Genetics, University Hospital, Institute for Biomedical Research, 22 Boulevard Gambetta, 76183, Rouen, France.
Baert-Desurmont
S
S
Latouche
J B
JB
Vasseur
S
S
Martin
C
C
Bouvignies
E
E
Frébourg
T
T
D020413:3' Untranslated Regions; D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000328:Adult; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D008875:Middle Aged; D000070957:MutL Protein Homolog 1; D009687:Nuclear Proteins / Q000235:genetics*; D017384:Sequence Deletion
D020413:3' Untranslated Regions; D048868:Adaptor Proteins, Signal Transducing; C501486:MLH1 protein, human; D009687:Nuclear Proteins; D000070957:MutL Protein Homolog 1