title: Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities.
abstract: TRIM5alpha is a potent barrier to cross-species retroviral transmission, and TRIM5alphas from different species have divergent antiretroviral specificities. Multiple TRIM5 alleles circulate within rhesus macaque populations. Here we show that they too have different antiretroviral specificities, highlighting how TRIM5 genotypes contribute to protection in an individual or a population.
authors.affiliation: Medical Research Council Centre for Medical Molecular Virology, Division of Infection and Immunity, University College and Royal Free Medical School, University College London, 46 Cleveland Street, London W1T4JF, United Kingdom.
authors.forename: Sam J
authors.initials: SJ
authors.lastname: Wilson
authors.forename: Benjamin L J
authors.initials: BL
authors.lastname: Webb
authors.forename: Charlotte
authors.initials: C
authors.lastname: Maplanka
authors.forename: Ruchi M
authors.initials: RM
authors.lastname: Newman
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Verschoor
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Heeney
authors.forename: Greg J
authors.initials: GJ
authors.lastname: Towers
mesh_terms: D000483:Alleles; D000818:Animals; D008253:Macaca mulatta / Q000235:genetics* / Q000276:immunology*; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics* / Q000276:immunology*; D044767:Ubiquitin-Protein Ligases
chemical_list: D011506:Proteins; C482587:TRIM5(alpha) protein, rhesus monkey; D044767:Ubiquitin-Protein Ligases