[Interaction of the new gestagen compound 17alpha-acetoxy-3beta-butanoyloxy-6-methylpregna-4,6-dien-20-one with human blood proteins and calf embryo serum].
Molecular mechanisms of sex hormones (progesterone, medroxyprogesterone acetate (MPA), and new synthetic gestagen 17alpha-acetoxy-3beta-butanoyloxy-6-methylpregna-4,6-dien-20-on (ABMP) with human serum albumin, globulins, and calf embryo serum were studied. The binding of ABMP to albumin and progesterone-binding proteins were investigated using spectroscopic techniques (with the use of 1-anilino-8-naphthalenesulfonate as fluorescent probe) and radiolabeled progesterone, (either progesteron or MPA as comparative progestines). There is no difference between the non-specific binding of ABMP, progesterone, and MPA, but the ABMP binding is much smaller as compared to the binding of progestines, so that the new progestine ABMP will produce a more effective action on the target tissue than comparative progestines.
Vetchinkina
V B
VB
Semeĭkin
A V
AV
Rzheznikov
V M
VM
Shimanovskiĭ
N L
NL
D019326:17-alpha-Hydroxyprogesterone / Q000031:analogs & derivatives* / Q000737:chemistry; D000818:Animals; D001798:Blood Proteins / Q000737:chemistry*; D002417:Cattle; D004622:Embryo, Mammalian; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000737:chemistry; D011374:Progesterone / Q000737:chemistry; D011372:Progestins / Q000737:chemistry*; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry*
C498329:17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one; D001798:Blood Proteins; D011372:Progestins; D012709:Serum Albumin; D011374:Progesterone; D019326:17-alpha-Hydroxyprogesterone; D017258:Medroxyprogesterone Acetate