title: Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration.
abstract: The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.
authors.affiliation: Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark. acj@farma.ku.dk
authors.forename: Anna Cecilia
authors.initials: AC
authors.lastname: Jørgensen
authors.forename: Anette Seo
authors.initials: AS
authors.lastname: Torstenson
mesh_terms: D002152:Calorimetry, Differential Scanning; D003975:Diazepam / Q000008:administration & dosage / Q000737:chemistry*; D004356:Drug Storage; D006813:Humidity; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000737:chemistry*; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D012995:Solubility; D019265:Spectroscopy, Near-Infrared; D013818:Thermogravimetry; D014867:Water / Q000032:analysis; D014961:X-Ray Diffraction
chemical_list: D006993:Hypnotics and Sedatives; D014867:Water; D003975:Diazepam