title: Explanatory models for psychiatric illness.
abstract: How can we best develop explanatory models for psychiatric disorders? Because causal factors have an impact on psychiatric illness both at micro levels and macro levels, both within and outside of the individual, and involving processes best understood from biological, psychological, and sociocultural perspectives, traditional models of science that strive for single broadly applicable explanatory laws are ill suited for our field. Such models are based on the incorrect assumption that psychiatric illnesses can be understood from a single perspective. A more appropriate scientific model for psychiatry emphasizes the understanding of mechanisms, an approach that fits naturally with a multicausal framework and provides a realistic paradigm for scientific progress, that is, understanding mechanisms through decomposition and reassembly. Simple subunits of complicated mechanisms can be usefully studied in isolation. Reassembling these constituent parts into a functioning whole, which is straightforward for simple additive mechanisms, will be far more challenging in psychiatry where causal networks contain multiple nonlinear interactions and causal loops. Our field has long struggled with the interrelationship between biological and psychological explanatory perspectives. Building from the seminal work of the neuronal modeler and philosopher David Marr, the author suggests that biology will implement but not replace psychology within our explanatory systems. The iterative process of interactions between biology and psychology needed to achieve this implementation will deepen our understanding of both classes of processes.
authors.affiliation: Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, Richmond, VA 23298-0126, USA. kendler@vcu.edu
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Kendler
mesh_terms: D000437:Alcoholism / Q000209:etiology / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000503:physiopathology; D015984:Causality; D003466:Cultural Characteristics; D006801:Humans; D007389:Internal-External Control; D001523:Mental Disorders / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D008962:Models, Theoretical; D012307:Risk Factors; D012931:Social Environment; D012959:Socioeconomic Factors