title: NOX enzymes and Toll-like receptor signaling.
abstract: Invading microorganisms are recognized by the host innate immune system through pattern recognition receptors. Among these receptors, Toll-like receptors (TLRs) are able to sense the molecular signatures of microbial pathogens, protozoa, fungi, and virus and activate proinflammatory signaling cascades. In addition to their role in bacterial killing by phagocytes, reactive oxygen species generated by NADPH oxidase (NOX) homologues also play key roles in signaling and host defense in a variety of cell types. Recent studies have demonstrated a link between TLR activation and NOX homologues following microbial recognition highlighting their important role in the innate immune response and host defense.
authors.affiliation: INSERM, U773, Centre de Recherche Biomédicale Bichat Beaujon, CRB3, BP 416, 75018 Paris, France. ogier@bichat.inserm.fr
authors.forename: Eric
authors.initials: E
authors.lastname: Ogier-Denis
authors.forename: Sanae Ben
authors.initials: SB
authors.lastname: Mkaddem
authors.forename: Alain
authors.initials: A
authors.lastname: Vandewalle
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D019255:NADPH Oxidases / Q000276:immunology* / Q000378:metabolism; D051193:Toll-Like Receptors / Q000276:immunology* / Q000378:metabolism
chemical_list: D051193:Toll-Like Receptors; D019255:NADPH Oxidases