title: Synthesis of the C1-C23 fragment of Spirastrellolide A.
abstract: Synthesis of the C1-C23 fragment in spirastrellolide A is described, featuring a cyclic acetal-tethered RCM for stereoselective constructions of spiroketal, and a 1,3- anti aldol involving methyl ketone enolate and Mukaiyama conditions.
authors.affiliation: Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, WI 53705-2222, USA.
authors.forename: Jin-Haek
authors.initials: JH
authors.lastname: Yang
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung
mesh_terms: D000818:Animals; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D013141:Spiro Compounds; D013237:Stereoisomerism
chemical_list: D018942:Macrolides; D013141:Spiro Compounds; C475125:spirastrellolide A