Selective expression of progesterone receptor in malignant melanoma was inversely correlated with PCNA.
To investigate the role of progesterone receptor (PR) expression in malignant melanoma (MM), PR and proliferative cell nuclear antigen (PCNA) expression were immunohistochemistrically evaluated in a series of 35 specimens of MM, and the correlation between the immunohistochemistrical findings and clinicopathological data was also analyzed. PR expression was detected in 25.7% (9/35) of the patients with MM. No PR expression was observed in nevi. PR expression was inversely correlated with PCNA expression (r=-0.353, P=0.026). PR expression was slightly increased in females, subjects aged under 55 y, those with ulceration, non-acral subtype and diagnosis delay longer than 1 y, but the difference was not statistically significant. Selective expression of progesterone receptor in malignant melanoma might be correlated with inhibited tumor growth.
Li
Jiawen
J
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Fang
Xianfeng
X
Chen
Xu'e
X
Chen
Jing
J
D000818:Animals; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000378:metabolism*; D051379:Mice; D008875:Middle Aged; D008954:Models, Biological; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000096:biosynthesis* / Q000235:genetics; D012867:Skin / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism
D018809:Proliferating Cell Nuclear Antigen; D011980:Receptors, Progesterone