Anthelmintic acetogenin from Annona squamosa L. Seeds.
Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml(-1). The structure of 1 was determined as a C37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis.
Souza
Marta M C
MM
Laboratório de Doenças Parasitárias, Universidade Estadual do Ceará, Fortaleza, CE, Brazil.
Bevilaqua
Claudia M L
CM
Morais
Selene M
SM
Costa
Cícero T C
CT
Silva
Ana R A
AR
Braz-Filho
Raimundo
R
D054378:Acetogenins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D031041:Annona / Q000737:chemistry*; D000871:Anthelmintics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006189:Haemonchus / Q000187:drug effects*; D010063:Ovum / Q000187:drug effects*; D021261:Parasitic Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D013057:Spectrum Analysis
D054378:Acetogenins; D000871:Anthelmintics; D010936:Plant Extracts