A case of systemic lupus erythematosus presenting as hypoglycemia due to anti-insulin receptor antibodies.
We describe herein a patient with hypoglycemia due to anti-insulin receptor antibodies in systemic lupus erythematosus (SLE). A 40-year-old Japanese woman with a 10-year follow-up for SLE was admitted with hypoglycemia. Her blood test revealed the presence of anti-insulin receptor antibody, normal level of insulin and C-peptide, and negative for anti-insulin antibody. Her symptoms responded well to the therapy of predonisolone (30 mg/day) and continuous intravenous glucose as anti-insulin receptor antibody became negative. We emphasize here the significance of these antibodies in complicating the SLE-associated hypoglycemia.
Kato
Yuuka
Y
Department of Dermatology, School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan.
Ichiki
Yoshiro
Y
Kitajima
Yasuo
Y
D000328:Adult; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D007330:Insulin Antibodies / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D011239:Prednisolone / Q000627:therapeutic use; D011972:Receptor, Insulin / Q000276:immunology*; D016896:Treatment Outcome
D001323:Autoantibodies; D005938:Glucocorticoids; D007330:Insulin Antibodies; D011239:Prednisolone; D011972:Receptor, Insulin