title: Antioxidant 2-phenylbenzofurans and a coumestan from Lespedeza virgata.
abstract: Two 2-phenylbenzofurans, lespedezavirgatol (1) and lespedezavirgatal (2), and a coumestan, lespedezacoumestan (3), were isolated from the aerial parts of Lespedeza virgata, together with nine known flavonoids. Their structures were determined on the basis of spectroscopic data. The three new compounds showed strong oxygen radical absorbance capacity and potent inhibition toward lipid peroxidation in both plasma and kidney homogenate of renal failure rats.
authors.affiliation: Department of Pharmacology, School of Traditional Chinese Medicine, Southern Medical UniVersity, Guangzhou 510515, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
authors.forename: Haihui
authors.initials: H
authors.lastname: Xie
authors.forename: Hongzhu
authors.initials: H
authors.lastname: Deng
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D029884:Lespedeza / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D000975:Antioxidants; D001572:Benzofurans; D003374:Coumarins; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C530687:lespedezacoumestan; C530686:lespedezavirgatal; C530685:lespedezavirgatol; C505898:coumestan; D001205:Ascorbic Acid