title: A case with life-threatening interstitial pneumonia associated with bucillamine treatment.
abstract: We report a case of bucillamine-induced interstitial pneumonia accompanied by severe hypoxemia in an 83-year-old woman who had rheumatoid arthritis. Respiratory failure worsened even after withdrawal of bucillamine and administration of high-dose corticosteroids, and mechanical ventilation was required. A review of 15 cases with bucillamine-induced pulmonary injury suggests that advanced age may be associated with the development of severe interstitial pneumonia. Bucillamine can cause corticosteroid-resistant and life-threatening lung injury, especially in the elderly.
authors.affiliation: Division of Respiratory Medicine, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakae-Cho, Itabashi-Ku, Tokyo, 177-0015, Japan.
authors.forename: Yuiko
authors.initials: Y
authors.lastname: Ogiwara
authors.forename: Hideaki
authors.initials: H
authors.lastname: Mochizuki
authors.forename: Takehiko
authors.initials: T
authors.lastname: Morioka
authors.forename: Takahiko
authors.initials: T
authors.lastname: Sugihara
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Makino
authors.forename: Hideki
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000369:Aged, 80 and over; D000975:Antioxidants / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003545:Cysteine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000975:Antioxidants; D003545:Cysteine; C026535:bucillamine