Tissue microarray: a simple technology that has revolutionized research in pathology.
Tissue microarray (TMA) technology is a high-throughput research tool, which has greatly facilitated and accelerated tissue analyses by in-situ technologies. TMAs are amenable to every research method that can be applied on the standard whole sections at enhanced speed. It plays a central role in target verification of results from cDNA arrays, expression profiling of tumors and tissues, and is proving to be a powerful platform for proteomic research. In this review article, primarily meant for students of pathology and oncology, we briefly discuss its basic methodology, applications and merits and limitations.
Avninder
S
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Institute of Pathology-ICMR, New Delhi, India. dravninder@yahoo.co.in
Ylaya
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K
Hewitt
S M
SM
D014408:Biomarkers, Tumor / Q000235:genetics; D003584:Cytological Techniques / Q000379:methods* / Q000639:trends; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods / Q000639:trends; D025202:Molecular Diagnostic Techniques; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D011379:Prognosis; D011786:Quality Control; D046888:Tissue Array Analysis / Q000379:methods* / Q000639:trends
D014408:Biomarkers, Tumor