title: Synthesis and structure-activity relationship of aminopyrimidine IKK2 inhibitors.
abstract: The synthesis and structure-activity relationship of a novel series of aminopyrimidines are exemplified. Results of key compounds from within this series in the E-selectin reporter cell assay are also reported.
authors.affiliation: UCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK.
authors.forename: Alistair H
authors.initials: AH
authors.lastname: Bingham
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Davenport
authors.forename: Richard
authors.initials: R
authors.lastname: Fosbeary
authors.forename: Lewis
authors.initials: L
authors.lastname: Gowers
authors.forename: Roland L
authors.initials: RL
authors.lastname: Knight
authors.forename: Christopher
authors.initials: C
authors.lastname: Lowe
authors.forename: David A
authors.initials: DA
authors.lastname: Owen
authors.forename: David M
authors.initials: DM
authors.lastname: Parry
authors.forename: Will R
authors.initials: WR
authors.lastname: Pitt
mesh_terms: D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D019040:E-Selectin / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors*; D008958:Models, Molecular; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D019040:E-Selectin; D004791:Enzyme Inhibitors; D011743:Pyrimidines; D051550:I-kappa B Kinase