title: [Guidelines for prevention of febrile neutropenia].
abstract: Neutropenia and febrile neutropenia are common consequences of some cytotoxic chemotherapy regimens. This situation leads to modifications of the therapeutic regimen, conducting to either dose reduction or cycle delays. Granulocyte colony stimulating factors are commonly used to minimize chemotherapy cytotoxic effect on the granulocytic series. The objective of this study is to assess the available evidence in what concerns the efficacy and safety of granulocyte colony stimulating factors, in several settings of their use. An extensive bibliographic review was performed, including clinical trials, observational studies, systematic reviews, and international guidelines for neutropenia prophylaxis, which aims to establish recommendations on their use, in adequacy to the National reality.
authors.affiliation: Serviço de Oncologia, Hospital do Espírito Santo, Evora.
authors.forename: Sérgio
authors.initials: S
authors.lastname: Barroso
authors.forename: Margarida
authors.initials: M
authors.lastname: Damasceno
authors.forename: José
authors.initials: J
authors.lastname: Dinis
authors.forename: Helena
authors.initials: H
authors.lastname: Gervásio
authors.forename: Ricardo
authors.initials: R
authors.lastname: da Luz
authors.forename: J L
authors.initials: JL
authors.lastname: Passos-Coelho
authors.forename: Anabela
authors.initials: A
authors.lastname: Sá
authors.forename: Luís
authors.initials: L
authors.lastname: Costa
authors.forename: Helena
authors.initials: H
authors.lastname: Rodrigues
authors.forename: Sofia
authors.initials: S
authors.lastname: Andrade
authors.forename: Ana
authors.initials: A
authors.lastname: Macedo
authors.forename: Inês
authors.initials: I
authors.lastname: Moital
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D005334:Fever / Q000139:chemically induced / Q000150:complications / Q000517:prevention & control*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications / Q000517:prevention & control*; D017410:Practice Guidelines as Topic
chemical_list: D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor