title: Large cell transformation mimicking regional lymphomatoid papulosis in a patient with mycosis fungoides.
abstract: A 57-year-old Japanese man with tumor-stage mycosis fungoides suddenly presented multiple small papules on the right chest. Histopathology of a biopsy specimen from the papules revealed medium-to-large pleomorphic lymphoid cells throughout the entire dermis but not in the epidermis, and the large cells expressed CD30 antigen. These newly-developed papules underwent spontaneous remission in the following 3 months. We reviewed the reported cases of mycosis fungoides, which showed CD30-positive large cell transformation and those of CD30-positive lymphoproliferative disorders associated with mycosis fungoides.
authors.affiliation: Department of Dermatology, Kyoto University Hospital, Kyoto, Japan. itononaka@ybb.ne.jp
authors.forename: Kyoko
authors.initials: K
authors.lastname: Nakahigashi
authors.forename: Yuya
authors.initials: Y
authors.lastname: Ishida
authors.forename: Yumi
authors.initials: Y
authors.lastname: Matsumura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kore-Eda
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Ohmori
authors.forename: Masakazu
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Kyoko
authors.initials: K
authors.lastname: Yamashita
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kotani
authors.forename: Takaaki
authors.initials: T
authors.lastname: Sakurai
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Miyachi
mesh_terms: D001706:Biopsy; D002471:Cell Transformation, Neoplastic; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis; D017731:Lymphomatoid Papulosis / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy / Q000473:pathology*; D011701:PUVA Therapy; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D017730:Ki-1 Antigen