title: MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not.
abstract: The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(-1306T) and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-9 levels were associated with poor prognosis but SNP MMP-9(-1562C>T) was not. Tumour MMP levels were not determined by their SNP genotypes.
authors.affiliation: Department of Gastroenterology-Hepatology, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: A M J
authors.initials: AM
authors.lastname: Langers
authors.forename: C F M
authors.initials: CF
authors.lastname: Sier
authors.forename: L J A C
authors.initials: LJ
authors.lastname: Hawinkels
authors.forename: F J G M
authors.initials: FJ
authors.lastname: Kubben
authors.forename: W
authors.initials: W
authors.lastname: van Duijn
authors.forename: J J
authors.initials: JJ
authors.lastname: van der Reijden
authors.forename: C B H W
authors.initials: CB
authors.lastname: Lamers
authors.forename: D W
authors.initials: DW
authors.lastname: Hommes
authors.forename: H W
authors.initials: HW
authors.lastname: Verspaget
mesh_terms: D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000401:mortality; D005838:Genotype; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011401:Promoter Regions, Genetic
chemical_list: D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9