Control of epithelial cell structure and developmental fate: lessons from Helicobacter pylori.
Valuable insights into eukaryotic regulatory circuits can emerge from studying interactions of bacterial pathogens such as Helicobacter pylori with host tissues. H. pylori uses a type IV secretion system (T4SS) to deliver its CagA virulence protein to epithelial cells, where much of it becomes phosphorylated. CagA's phosphorylated and non-phosphorylated forms each interact with host regulatory proteins to alter cell structure and cell fate. Kwok and colleagues showed that CagA destined for phosphorylation is delivered using host integrin as receptor and H. pylori's CagL protein as an integrin-specific adhesin, and that CagL-integrin-binding activates the kinase cascade responsible for CagA phosphorylation. This research contributes to understanding infectious disease and the control of cell fates.
Mimuro
Hitomi
H
Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. mim@ims.u-tokyo.ac.jp
Berg
Douglas E
DE
Sasakawa
Chihiro
C
D018829:Adhesins, Bacterial / Q000502:physiology; D000942:Antigens, Bacterial / Q000502:physiology; D001422:Bacterial Adhesion / Q000502:physiology; D001426:Bacterial Proteins / Q000502:physiology; D016764:Cell Polarity; D004847:Epithelial Cells / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D005753:Gastric Mucosa / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000209:etiology; D016481:Helicobacter Infections / Q000209:etiology; D016480:Helicobacter pylori / Q000472:pathogenicity* / Q000502:physiology; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000378:metabolism; D008954:Models, Biological; D010766:Phosphorylation; D015398:Signal Transduction; D014774:Virulence / Q000502:physiology
D018829:Adhesins, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D016023:Integrins; C080866:cagA protein, Helicobacter pylori