title: Vitamin D-receptor polymorphisms and non-tuberculous mycobacterial lung disease in Korean patients.
abstract: This study investigated the potential role of vitamin D-receptor (VDR) gene polymorphisms in susceptibility to lung disease caused by non-tuberculous mycobacteria (NTM). TaqI and FokI polymorphisms were compared in 124 patients and 127 controls. The genotype, allele and haplotype frequencies did not differ between patients and controls. TaqI and FokI polymorphisms of the VDR gene do not appear to be responsible for host susceptibility to NTM lung disease, at least in this Korean population. An association cannot, however, be completely ruled out, as only two single nucleotide polymorphisms of the VDR gene were studied in this report.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: S
authors.initials: S
authors.lastname: Park
authors.forename: E J
authors.initials: EJ
authors.lastname: Kim
authors.forename: S-H
authors.initials: SH
authors.lastname: Lee
authors.forename: G Y
authors.initials: GY
authors.lastname: Suh
authors.forename: M P
authors.initials: MP
authors.lastname: Chung
authors.forename: H
authors.initials: H
authors.lastname: Kim
authors.forename: O J
authors.initials: OJ
authors.lastname: Kwon
authors.forename: W-J
authors.initials: WJ
authors.lastname: Koh
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D006801:Humans; D007723:Korea; D008171:Lung Diseases / Q000208:ethnology / Q000235:genetics* / Q000382:microbiology; D008297:Male; D009164:Mycobacterium Infections / Q000235:genetics*; D015270:Mycobacterium avium-intracellulare Infection / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol