[Small animal MRI: clinical MRI as an interface to basic biomedical research].
The demand for highly resolved small animal MRI for the purpose of biomedical research has increased constantly. Dedicated small animal MRI scanners working at ultra high field strengths from 4.7 to 7.0 T and even above are MRI at its best. However, using high resolution RF coils in clinical scanners up to 3.0 T, small animal MRI can achieve highly resolved images showing excellent tissue contrast. In fact, in abundant experimental studies, clinical MRI is used for small animal imaging. Mostly clinical RF coils in the single-loop design are applied. In addition, custom-built RF coils and even gradient inserts are used in a clinical scanner. For the reduction of moving artifacts, special MRI-compatible animal ECG und respiration devices are available. In conclusion, clinical devices offer broad availability, are less expense in combination with good imaging performance and provide a translational nature of imaging results.
Pinkernelle
J G
JG
Institut für Radiologie, Charité Universitätsmedizin Berlin, Berlin. jens.pinkernelle@charite.de
Stelter
L
L
Hamm
B
B
Teichgräber
U
U
D000818:Animals; D000830:Animals, Laboratory; D016477:Artifacts; D004562:Electrocardiography / Q000295:instrumentation; D004867:Equipment Design; D007089:Image Enhancement / Q000295:instrumentation*; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology; D051381:Rats