title: Highly enantioselective synthesis of isoxazoline N-oxides.
abstract: The reaction of cinchonidine (cinchonine)-derived ammonium salts with nitroolefins in the presence of Cs2CO3 to afford optically active isoxazoline N-oxides with excellent ee and high de values has been developed.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
authors.forename: Chun-Yin
authors.initials: CY
authors.lastname: Zhu
authors.forename: Xian-Ming
authors.initials: XM
authors.lastname: Deng
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Sun
authors.forename: Jun-Cheng
authors.initials: JC
authors.lastname: Zheng
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang
mesh_terms: D002930:Cinchona Alkaloids / Q000737:chemistry; D003497:Cyclic N-Oxides / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002930:Cinchona Alkaloids; D003497:Cyclic N-Oxides; D007555:Isoxazoles; D000644:Quaternary Ammonium Compounds; C041622:cinchonidine