title: [Transbronchial biopsy of the lungs in diagnosis of respiratory sarcoidosis].
abstract: OBJECTIVE
  To specify diagnostic potentialities of transbronchial biopsy of the lungs (TBB) in respiratory sarcoidosis (RS).
  
  
  METHODS
  TBB of the lungs was performed in bronchofibroscopy under local anesthesia and TV x-ray control with intake of 4-5 biopsy specimens.
  
  
  RESULTS
  Biopsy specimens consisted primarily of alveolar tissue in 62.5% patients, of bronchial wall - in 34.8%, were insufficiently informative - in 2.4% patients. Histological examination of the biopsies detected sarcoid granulemas which served the basis for RS diagnosis in 62.5% patients (stage 1 - 51.1%, stage 2 - 70.4%, stage 3 - in 61.6%). Sarcoid granulemas were detected more frequently in alveolar tissue than in bronchial walls (75.3 and 38.5%, respectively, p < 0.05). In RS stage 1 granulemas in the bronchial walls were found less often than in stages 2 and 3 (56.3, 42.9%, respectively, p < 0.01).
  
  
  CONCLUSIONS
  TBB provides morphological RS diagnosis in 2/3 patients and is a safe method. Obtaining biopsies containing alveolar tissue raises efficacy of TBB, especially in the disease stage 1.
authors.forename: V A
authors.initials: VA
authors.lastname: Gerasin
authors.forename: V P
authors.initials: VP
authors.lastname: Molodtsova
authors.forename: I V
authors.initials: IV
authors.lastname: Dvorakovskaia
authors.forename: A V
authors.initials: AV
authors.lastname: Derevianko
authors.forename: A A
authors.initials: AA
authors.lastname: Bazhanov
authors.forename: O P
authors.initials: OP
authors.lastname: Baranova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods*; D001980:Bronchi; D001999:Bronchoscopy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D017565:Sarcoidosis, Pulmonary / Q000473:pathology*