title: Myocardial involvement in systemic sclerosis.
abstract: OBJECTIVE
  To identify clinical and/or laboratory characteristics that could be risk factors for myocardial microvascular involvement in patients with SSc.
  
  
  METHODS
  Twenty-one SSc patients, clinically silent for cardiovascular disease, were consecutively evaluated for myocardial perfusion defects through 99m-Tc sestamibi gated myocardial perfusion SPECT with a stress-rest protocol.
  
  
  RESULTS
  Eight patients (38%) had myocardial perfusion defects. Perfusion defects were related to skin scores (P < 0.0001), digital ulcers (P = 0.02) and oesophageal involvement (P = 0.046). A trend for anti-Scl 70 antibody positivity was observed in these patients (P = 0.09). Three SPECT-positive patients had re-establishment of normal myocardial perfusion after a course of prostanoid therapy. There were no significant associations between myocardial involvement and age, sex, diffuse/limited SSc, duration of RP or lung involvement.
  
  
  CONCLUSIONS
  Myocardial perfusion defects in SSc patients are frequent, and the presence of severe skin thickness, digital ulcers and perhaps oesophageal involvement might warrant screening for myocardial involvement. Further studies are necessary to evaluate the effect of prostanoid therapy on myocardial perfusion.
authors.affiliation: Rheumatology Unit, IRCCS Humanitas Clinical Institute, University of Milan, Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Belloli
authors.forename: N
authors.initials: N
authors.lastname: Carlo-Stella
authors.forename: G
authors.initials: G
authors.lastname: Ciocia
authors.forename: A
authors.initials: A
authors.lastname: Chiti
authors.forename: M
authors.initials: M
authors.lastname: Massarotti
authors.forename: B
authors.initials: B
authors.lastname: Marasini
mesh_terms: D000328:Adult; D000368:Aged; D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000150:complications* / Q000000981:diagnostic imaging; D012720:Severity of Illness Index; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi