[Changes of plasma B-type natriuretic peptide level during non-invasive ventilation in treating acute left heart failure].
OBJECTIVE
To assess the changes of B-type natriuretic peptide (BNP) levels during noninvasive ventilation in treating acute left heart failure.


METHODS
Totally 28 patients with acute left heart failure were randomly assigned to group A (n = 13; without non-invasive ventilation) and group B (n = 15; undergoing non-invasive ventilation). Another 10 healthy adults were enrolled as the normal control group. Plasma BNP were obtained with ELISA before treatment and 3 and 7 hours after treatment.


RESULTS
The plasma BNP levels were significantly higher in group A and group B than in the normal control group before treatment (P< 0.01). Three and 7 hours after treatment, the plasma BNP levels was significantly higher in group A than in the normal control group (P<0.05), while it was significantly lower in group B than in group A (P<0.05, P<0.01).


CONCLUSIONS
The plasma BNP level remarkably decreases in patients undergo non-invasive ventilation, suggesting that the plasma BNP level decreases along with the improvement of cardiac function.
Zhang
Hai-Yan
HY
Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Li
Chun-Sheng
CS
D000368:Aged; D000369:Aged, 80 and over; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000628:therapy*; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D016896:Treatment Outcome
D020097:Natriuretic Peptide, Brain