title: [New treatments in hypertension: direct renin inhibitors].
abstract: For the last several years, the development of potent, orally administered renin inhibitors has been advancing rapidly, and the first drug of this class was recently approved for use by the FDA. These renin inhibitors have potent blood pressure reducing effects, and also possess beneficial effects on the heart and kidney. The purpose of this review is to summarize the current knowledge on this new treatment, and to describe possible future applications.
authors.affiliation: Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada. eleibovitz@jgh.mcgill.ca
authors.forename: Eyal
authors.initials: E
authors.lastname: Leibovitz
authors.forename: Ernesto L
authors.initials: EL
authors.lastname: Schiffrin
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D014481:United States; D014486:United States Food and Drug Administration; D000092502:Renin Inhibitors
chemical_list: D000959:Antihypertensive Agents; D000092502:Renin Inhibitors