title: Antipyretic effect of ibuprofen in Gabonese children with uncomplicated falciparum malaria: a randomized, double-blind, placebo-controlled trial.
abstract: BACKGROUND
  Antipyretic drugs are widely used in children with fever, though there is a controversy about the benefit of reducing fever in children with malaria. In order to assess the effect of ibuprofen on fever compared to placebo in children with uncomplicated Plasmodium falciparum malaria in Gabon, a randomized double blind placebo controlled trial, was designed.
  
  
  METHODS
  Fifty children between two and seven years of age with uncomplicated malaria were included in the study. For the treatment of fever, all patients "received" mechanical treatment when the temperature rose above 37.5 degrees C. In addition to the mechanical treatment, continuous fanning and cooling blanket, patients were assigned randomly to receive ibuprofen (7 mg/kg body weight, every eight hours) or placebo.
  
  
  RESULTS
  The fever clearance time using a fever threshold of 37.5 degrees C was similar in children receiving ibuprofen compared to those receiving placebo. The difference was also not statistically significant using a fever threshold of 37.8 degrees C or 38.0 degrees C. However, the fever time and the area under the fever curve were significantly smaller in the ibuprofen group compared to the placebo group.
  
  
  CONCLUSIONS
  Ibuprofen is effective in reducing the time with fever. The effect on fever clearance is less obvious and depends on definition of the fever threshold.
  
  
  BACKGROUND
  The trial registration number is: NCT00167713.
authors.affiliation: Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon. matsiegpb@yahoo.fr
authors.forename: Pierre-Blaise
authors.initials: PB
authors.lastname: Matsiégui
authors.forename: Michel A
authors.initials: MA
authors.lastname: Missinou
authors.forename: Magdalena
authors.initials: M
authors.lastname: Necek
authors.forename: Elie
authors.initials: E
authors.lastname: Mavoungou
authors.forename: Saadou
authors.initials: S
authors.lastname: Issifou
authors.forename: Bertrand
authors.initials: B
authors.lastname: Lell
authors.forename: Peter G
authors.initials: PG
authors.lastname: Kremsner
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D000818:Animals; D019540:Area Under Curve; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D005681:Gabon; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D010963:Plasmodium falciparum / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D018712:Analgesics, Non-Narcotic; D007052:Ibuprofen