The p53 network modeling - current state and future prospects.
p53 gene is a central hub in a network that have the role to protect the cells against carcinogenesis. A lot of research work has been done in this field, a huge amount of data was collected and many experiments have been performed. For a better understanding of the processes and for the help of experiments design some mathematical models were proposed in the literature. In this paper we make a brief overview of these models, pointing out their strong points and weak points. Some improvements of the models were also presented with some graphical representations of numerical simulation. Finally some conclusions were made regarding future prospects of p53 network modeling.
Horhat
Raul Florin
RF
University of Medicine and Pharmacy Timisoara, Romania. rhorhat@umft.ro
Mihalas
Gheorghe I
GI
Neamtu
Mihaela
M
D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D003198:Computer Simulation; D004249:DNA Damage; D004843:Epistasis, Genetic; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D008962:Models, Theoretical; D016571:Neural Networks, Computer; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics
C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2