Ageing within the hematopoietic stem cell compartment.
As we humans are far too aware, all mammals have a finite lifespan. Apart from basic longevity, age is also a major risk factor for most cancers and diseases. Since adult stem cells are responsible for maintaining tissue homeostasis throughout an organism's lifetime, an attractive theory is that ageing-related phenotypes might be, at least in part, due to an alteration in the number and/or function of tissue stem cells. Here, we have focused on hematopoietic stem cells as they are one of the best-characterized adult stem cell populations, and have been extensively studied for the consequences of ageing in vivo and in vitro.
Pearce
Daniel
D
Hematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK.
Bonnet
Dominique
D
D000368:Aged; D000375:Aging / Q000502:physiology*; D017209:Apoptosis / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans