title: Moving beyond tight glucose control to safe effective glucose control.
abstract: The impressive benefits related to the use of tight glucose control by intensive insulin therapy have not been reproduced until now in multicenter large-scale prospective randomized trials. Although the reasons for these failures are not entirely clear, we suggest the use of a stepwise approach - Safe, Effective Glucose Control - that will essentially target an intermediate blood glucose level. As compared with genuine tight glucose control, Safe, Effective Glucose Control - already used in many intensive care units worldwide - is intended to decrease the rate of hypoglycemia and the workload, while reducing the adverse effects of severe hyperglycemia.
authors.affiliation: Division of Critical Care, Stamford Hospital, 190 West Broad Street, Stamford, CT 06902, USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Krinsley
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Preiser
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D003422:Critical Care; D006801:Humans; D007003:Hypoglycemia / Q000517:prevention & control; D007328:Insulin / Q000627:therapeutic use; D008991:Monitoring, Physiologic
chemical_list: D001786:Blood Glucose; D007328:Insulin