title: Clinical and radiological features of Pneumocystis pneumonia in patients with rheumatoid arthritis, in comparison with methotrexate pneumonitis and Pneumocystis pneumonia in acquired immunodeficiency syndrome: a multicenter study.
abstract: OBJECTIVE
  To elucidate the clinical and radiological features of Pneumocystis pneumonia (PCP) in patients with rheumatoid arthritis (RA), compared with methotrexate (MTX) pneumonitis in RA and Pneumocystis pneumonia in acquired immunodeficiency syndrome (AIDS).
  
  
  METHODS
  Retrospective analysis of 14 PCP cases in RA (RA-PCP), 10 MTX pneumonitis cases in RA (MTX-P) and 11 PCP cases in AIDS (AIDS-PCP) from 9 centers in the Kanto area in the last 6 years.
  
  
  RESULTS
  Compared with AIDS-PCP, both RA-PCP and MTX-P developed more rapidly, showing higher serum CRP and lower plasma beta-D-glucan levels, and more severe oxygenation impairment. In most of the RA-PCP cases, a high dose of corticosteroid was administered as adjunctive therapy, resulting in a favorable outcome. The mortality was 14% in RA-PCP, 0% in AIDS-PCP and 0% in MTX-P cases. In RA-PCP patients the CD4 cell count showed only mild suppression, not reaching the predisposing level for PCP in HIV infection, suggesting that there are risk factors for RA-PCP other than immunosuppression. Radiologic analysis revealed some characteristic patterns of each disease. In MTX-P, diffuse homogeneous ground glass opacity (GGO) with sharp demarcation by interlobular septa (type A GGO) was found in 70%, while in AIDS-PCP diffuse, homogeneous or nonhomogeneous GGO without interlobular septal boundaries (type B GGO) was predominant (91%). In RA-PCP, type A GGO was found in 6 cases and type B GGO in 5 cases, showing the complex nature of this disease.
  
  
  CONCLUSIONS
  RA-PCP differed considerably from AIDS-PCP clinically and radiologically. Clinically it occurred without severe immunosuppression, and showed characteristic aspects, with more intense inflammation and less parasite burden. Radiologically it mimicked MTX-P in some cases sharing the conspicuous CT features of MTX-P, rendering the distinction of these two disorders difficult.
authors.affiliation: Department of Internal Medicine, Social Health Insurance Central General Hospital, Tokyo. tokuda-h@mc.neweb.ne.jp
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tokuda
authors.forename: Fumikazu
authors.initials: F
authors.lastname: Sakai
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Yamada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Johkoh
authors.forename: Akifumi
authors.initials: A
authors.lastname: Imamura
authors.forename: Makoto
authors.initials: M
authors.lastname: Dohi
authors.forename: Michito
authors.initials: M
authors.lastname: Hirakata
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamada
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kamatani
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Shoji
authors.initials: S
authors.lastname: Sugii
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tateda
authors.forename: Hajime
authors.initials: H
authors.lastname: Goto
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000382:microbiology*; D002097:C-Reactive Protein / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D045363:Pneumocystis carinii / Q000302:isolation & purification / Q000472:pathogenicity; D011014:Pneumonia / Q000097:blood / Q000139:chemically induced / Q000000981:diagnostic imaging*; D011020:Pneumonia, Pneumocystis / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D047071:beta-Glucans / Q000097:blood
chemical_list: D007166:Immunosuppressive Agents; D047071:beta-Glucans; D002097:C-Reactive Protein; D008727:Methotrexate