title: Cell therapy in patients with left ventricular dysfunction due to myocardial infarction.
abstract: OBJECTIVE
  The purpose of this study was to determine the impact of autologous transplantation of mononuclear bone marrow cells on myocardial function in patients with left ventricular (LV) dysfunction due to an acute myocardial infarction.
  
  
  METHODS
  The randomized study included 82 patients with a first acute myocardial infarction treated with a stent implantation. This presentation is a subanalysis of 47 patients with left ventricular dysfunction-EF (ejection fraction) <or= 40%. Group H patients (n = 17) received higher number (100,000,000) of cells; Group L patients (n = 13) received lower number (10,000,000) of cells. The patients of control Group C (n = 17) were not treated with cells. The Doppler tissue imaging and single photon emission computed tomography were performed before cell transplantation and 3 months later.
  
  
  RESULTS
  At 3 months of follow-up, the baseline EF of 35%, 36%, 35% in Groups H, L, and C increased by 6% (P < 0.01 vs. baseline), 5% (P < 0.01 vs. baseline), and 4% (P = NS vs. baseline), respectively, as assessed by single photon emission computed tomography (P = NS between groups). The baseline number of akinetic segments of 6.9, 7.0, and 6.2 in H, L, and C groups decreased by 1.7 (P < 0.01 vs. baseline), 1.5 (P < 0.01 vs. baseline), and 0.7 (P = NS vs. baseline, P = NS between groups), respectively, as demonstrated by echocardiography.
  
  
  CONCLUSIONS
  In our study, the statistically important effect of transplantation of mononuclear bone marrow cells on myocardial function was not found. Only an insignificant trend toward the improvement of global LV EF fraction was found at 3-month follow-up.
authors.affiliation: First Department of Internal Medicine/Cardioangiology, St. Anna Hospital, Masaryk University, Brno, Czech Republic. panovsky@fnusa.cz
authors.forename: Roman
authors.initials: R
authors.lastname: Panovsky
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Meluzin
authors.forename: Stanislav
authors.initials: S
authors.lastname: Janousek
authors.forename: Jirí
authors.initials: J
authors.lastname: Mayer
authors.forename: Milan
authors.initials: M
authors.lastname: Kaminek
authors.forename: Ladislav
authors.initials: L
authors.lastname: Groch
authors.forename: Jirí
authors.initials: J
authors.lastname: Prasek
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Stanicek
authors.forename: Ladislav
authors.initials: L
authors.lastname: Dusek
authors.forename: Ota
authors.initials: O
authors.lastname: Hlinomaz
authors.forename: Petr
authors.initials: P
authors.lastname: Kala
authors.forename: Martin
authors.initials: M
authors.lastname: Klabusay
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Koristek
authors.forename: Milan
authors.initials: M
authors.lastname: Navratil
mesh_terms: D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D016896:Treatment Outcome; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery*