title: Prospective evaluation of concurrent meniscus transplantation and articular cartilage repair: minimum 2-year follow-up.
abstract: BACKGROUND
  Recognition of the symbiotic relationship between the meniscus and articular cartilage is critical to the success of meniscal allograft transplantation. Simultaneous combined meniscal allograft transplantation and cartilage restoration procedures have been proposed for patients with a symptomatic postmeniscectomy knee with a focal chondral defect that would have traditionally been considered a contraindication to meniscal allograft transplantation.
  
  
  OBJECTIVE
  Combined meniscal allograft transplantation and cartilage restoration procedures can be used to neutralize traditional contraindications to meniscal allograft transplantation with results comparable to either procedure performed in isolation.
  
  
  METHODS
  Case series; Level of evidence, 4.
  
  
  METHODS
  Thirty patients underwent 31 combined meniscal allograft transplantation and cartilage restoration procedures between 1997 and 2004. These patients were prospectively studied, and completed standardized outcome surveys (including Lysholm, International Knee Documentation Committee, and Short Form-12 scales) preoperatively and annually thereafter for a minimum of 2-year follow-up. Patients were grouped according to concomitant procedure: 16 (52%) underwent meniscal allograft transplantation combined with autologous chondrocyte implantation; 15 (48%) had meniscal allograft transplantation combined with an osteochondral allograft. Two patients were lost to follow-up, leaving 29 procedures for review.
  
  
  RESULTS
  As a combined group, statistically significant improvements were observed in all standardized outcomes scores and satisfaction scales, except Short Form-12 mental, at a mean 3.1-year follow-up. Excluding the 2 lost to follow-up, 76% of all study participants (80% autologous chondrocyte implantation; 71% osteochondral allograft) reported that they were completely (31%) or mostly (45%) satisfied with their results. Overall, 48% of patients (60% autologous chondrocyte implantation; 36% osteochondral allograft) were classified as normal or nearly normal at their most recent follow-up using the International Knee Documentation Committee examination score. Ninety percent of patients would have the surgery again.
  
  
  CONCLUSIONS
  Combined meniscal allograft transplantation and cartilage restoration offers a safe alternative for patients with persistent symptoms after meniscectomy and focal cartilage injury. Results of combined procedures were comparable to published reports of these procedures performed in isolation. Long-term follow-up is needed to define the survivorship of these procedures in a young patient population.
authors.affiliation: Department of Orthopaedic Surgery, National Naval Medical Center, Bethesda, Maryland, USA.
authors.forename: John-Paul H
authors.initials: JP
authors.lastname: Rue
authors.forename: Adam B
authors.initials: AB
authors.lastname: Yanke
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Busam
authors.forename: Allison G
authors.initials: AG
authors.lastname: McNickle
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Cole
mesh_terms: D000293:Adolescent; D000328:Adult; D016025:Bone Transplantation; D002358:Cartilage, Articular / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D008297:Male; D008592:Menisci, Tibial / Q000637:transplantation*; D008875:Middle Aged; D011446:Prospective Studies; D012086:Reoperation; D014184:Transplantation, Homologous; D017211:Treatment Failure