IgE against food and respiratory allergens in healthy and allergic mothers and their children.
IgE against mixtures of common food or respiratory allergens were determined by ELISA in healthy (n = 38) and allergic (n = 62) mothers and their children. Significantly higher level of IgE against respiratory allergens was found in sera of allergic mothers and in cord blood of their children. No correlation between antibody level in maternal and newborn's sera was found; this argues against the transfer of IgE from mother to fetus and points rather to offspring's intrauterine sensitization. Specific IgE level in cord blood was higher in children who developed later allergy than in children who did not. Specific IgE level in colostrum was low both in healthy and allergic mothers; there was no correlation between high concentration of IgE against respiratory allergens in sera of allergic mothers and their colostrum, which does not support the idea of IgE transport from blood to mammary gland. Only slightly increased colostral IgE was detected in allergic mothers whose children manifested allergy later. Allergy of the mother and high level of anti-allergen IgE in her serum and in cord blood are the main predictive factors of future occurrence of allergy in the offspring. A combination of several predictive factors could have higher prognostic value.
Prokesová
L
L
Institute of Immunology and Microbiology, 1st Faculty of Medicine, Charles University in Prague, 128 00, Prague, Czechia. lprok@lfl.cuni.cz
Novotná
O
O
Janatková
I
I
Zanvit
P
P
Zizka
J
J
Lodinová-Zádníková
R
R
Kocourková
I
I
Sterzl
I
I
D003126:Colostrum / Q000276:immunology; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D005500:Follow-Up Studies; D005512:Food Hypersensitivity / Q000209:etiology / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity; D007073:Immunoglobulin E / Q000032:analysis* / Q000097:blood; D007223:Infant; D008297:Male; D008431:Maternal-Fetal Exchange; D008895:Milk, Human / Q000276:immunology; D009035:Mothers; D011247:Pregnancy; D012130:Respiratory Hypersensitivity / Q000209:etiology / Q000276:immunology*
D007073:Immunoglobulin E