South Asian chronic lymphocytic leukaemia patients have more rapid disease progression in comparison to White patients.
Ethnicity has a major impact on the prevalence of chronic lymphocytic leukaemia (CLL) and may also influence disease phenotype. We compared the clinical features of Southern Asian and White CLL patients managed within one UK region. Asians required treatment almost twice as often as Whites (HR, 1.94) and had a shorter time to first treatment (P = 0.0063). This difference remained significant after adjusting for stage, lymphocyte doubling time and IGHV status (P = 0.026). CLL was diagnosed at younger ages in Asians and racial-specific variations in IGHV usage were demonstrated. Our findings indicate that Southern Asian race has a negative impact on CLL phenotype.
Gunawardana
Chaminda
C
CRUK Institute for Cancer Studies, University of Birmingham, Birmingham, UK.
Austen
Belinda
B
Powell
Judith E
JE
Fegan
Christopher
C
Wandroo
Farooq
F
Jacobs
Abe
A
Pratt
Guy
G
Moss
Paul
P
D051997:ADP-ribosyl Cyclase 1 / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001208:Asia / Q000208:ethnology; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D018450:Disease Progression; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000208:ethnology* / Q000401:mortality / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis
D015415:Biomarkers; D051997:ADP-ribosyl Cyclase 1