title: Marine natural product libraries for high-throughput screening and rapid drug discovery.
abstract: There is a need for diverse molecular libraries for phenotype-selective and high-throughput screening. To make marine natural products (MNPs) more amenable to newer screening paradigms and shorten discovery time lines, we have created an MNP library characterized online using MS. To test the potential of the library, we screened a subset of the library in a phenotype-selective screen to identify compounds that inhibited the growth of BRCA2-deficient cells.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, 30 S. 2000 E. RM 307, Salt Lake City, Utah 84112, USA.
authors.forename: Tim S
authors.initials: TS
authors.lastname: Bugni
authors.forename: Burt
authors.initials: B
authors.lastname: Richards
authors.forename: Leen
authors.initials: L
authors.lastname: Bhoite
authors.forename: Daniel
authors.initials: D
authors.lastname: Cimbora
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Harper
authors.forename: Chris M
authors.initials: CM
authors.lastname: Ireland
mesh_terms: D000818:Animals; D024682:BRCA2 Protein / Q000172:deficiency*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D005367:Fiji; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D024682:BRCA2 Protein; D001688:Biological Products; D054852:Small Molecule Libraries; D004247:DNA