title: New pentacyclic triterpenes from Gypsophila oldhamiana and their biological evaluation as glycogen phosphorylase inhibitors.
abstract: The three new pentacyclic triterpenes 1-3 were isolated and elucidated from the roots of Gypsophila oldhamiana, together with seven known triterpenes (4-10). These triterpenes were evaluated for their glycogen phosphorylase inhibitory activity and preliminary structure-activity trends are suggested.
authors.affiliation: Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
authors.forename: Jian-Guang
authors.initials: JG
authors.lastname: Luo
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D029748:Caryophyllaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D024981:Glycogen Phosphorylase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D053978:Pentacyclic Triterpenes; D024981:Glycogen Phosphorylase