title: The influence of priming solutions used in cardiopulmonary bypass on blood viscosity in hypothermic conditions.
abstract: Vessel diameter, flow velocity, temperature, and viscosity are among the factors determining blood flow in vessels. To assess the influence of arterial blood flow on veins in a cardiac operation, the viscosity of blood diluted with priming solutions must be known. This study aimed to demonstrate the alteration of blood viscosity following dilution with priming solutions: hydroxyethyl starch (HES), gelatin, albumin, and Ringer's lactated solution (RL). Sixty volunteers were (15 female, 45 male) included in the study. Using a 50-ml syringe containing heparin, 40-ml fasting blood was drawn from antecubital veins. Six milliliters of blood was added to glass tubes previously filled with 2 ml of HES 6%, gelatin 4%, albumin, and RL solutions. Relative viscosity values of these mixtures were measured with an Ostwald viscometer device while the temperature was kept constant at 15 degrees C and 30 degrees C by means of a water bath. Measured viscosity values were compared with the calculated viscosity values and corrected values were obtained. All mixtures demonstrated decreased viscosity; however, it was evident that the mixtures containing HES and gelatin presented a lesser degree of decrease in viscosity when compared with the mixtures containing albumin and RL solution. Viscosity of all mixtures except RL decreased significantly at deep hypothermia (15 degrees C).
authors.affiliation: Cumhuriyet University, Cardiovascular Surgery, Sivas, Turkey.
authors.forename: Sinasi
authors.initials: S
authors.lastname: Manduz
authors.forename: Ismail
authors.initials: I
authors.lastname: Sapmaz
authors.forename: Umut Serhat
authors.initials: US
authors.lastname: Sanri
authors.forename: Oguz
authors.initials: O
authors.lastname: Karahan
authors.forename: Hasan
authors.initials: H
authors.lastname: Bascil
authors.forename: Kasim
authors.initials: K
authors.lastname: Dogan
mesh_terms: D000418:Albumins; D001809:Blood Viscosity; D002315:Cardiopulmonary Bypass / Q000379:methods*; D005260:Female; D005780:Gelatin; D006400:Hematocrit; D006438:Hemodilution / Q000379:methods*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D007036:Hypothermia, Induced; D066298:In Vitro Techniques; D007552:Isotonic Solutions; D008297:Male; D000077325:Ringer's Lactate; D012996:Solutions; D013694:Temperament
chemical_list: D000418:Albumins; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D012996:Solutions; D005780:Gelatin