[A case of advanced gastric cancer with Schnitzler's metastases effectively treated by the combination of paclitaxel and S-1].
The patient was a 70-year-old woman who underwent combined chemotherapy of paclitaxel (PTX) and S-1 after diagnosis of non-resectable advanced gastric cancer with Schnitzler's metastases. The administration schedule was as follows: 120 mg/m(2) of PTX on days 1 and 15 intravenously and 80 mg/m(2) of S-1 on days 1-14 orally. One course lasted for 4 weeks. The abdominal pain and appetite loss improved after the first course of chemotherapy, and therapeutic efficacy was rated PR. At present, there is no evidence of relapse or adverse reactions that require intervention after 4 courses. PTX and S-1 combination treatment promises good therapeutic efficacy and improves QOL in patients with advanced gastric cancer associated with Schnitzler's metastases.
Yamamoto
Manabu
M
Dept. of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital.
Matsuyama
Ayumi
A
Kameyama
Toshifumi
T
Okamoto
Masahiro
M
Okazaki
Jin
J
Utsunomiya
Tohru
T
Tsutsui
Shinichi
S
Ishida
Teruyoshi
T
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006801:Humans; D010094:Oxonic Acid / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000556:secondary; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005641:Tegafur / Q000008:administration & dosage
D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel