Evaluation of antibiotic therapy for eradication of "Candidatus Helicobacter heilmannii".
Triple-agent therapy with lansoprazole (15 mg/kg)-clarithromycin (50 mg/kg)-amoxicillin (50 mg/kg) twice daily for 7 days fully cleared "Candidatus Helicobacter heilmannii" from infected mouse stomachs. Moreover, gastric mucosa-associated lymphoid tissue lymphoma-like lesions in the stomach nearly disappeared in the treated mice 4 months after the therapy.
Matsui
Hidenori
H
Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641 Japan. hmatsui@lisci.kitasato-u.ac.jp
Aikawa
Chihiro
C
Sekiya
Yukie
Y
Takahashi
Shinichi
S
Murayama
Somay Yamagata
SY
Nakamura
Masahiko
M
D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000494:pharmacology / Q000627:therapeutic use; D000658:Amoxicillin / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D018247:Helicobacter heilmannii / Q000187:drug effects*; D064747:Lansoprazole; D008223:Lymphoma / Q000188:drug therapy / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D013270:Stomach / Q000187:drug effects* / Q000382:microbiology; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000382:microbiology; D016896:Treatment Outcome
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000900:Anti-Bacterial Agents; D064747:Lansoprazole; D000658:Amoxicillin