Captopril-induced lichen planus pemphigoides.
OBJECTIVE
To report a rare case of lichen planus pemphigoides (LPP) possibly induced by captopril.


METHODS
A 74-year-old woman developed pruriginous and bullous lichenoid eruption after starting captopril for hypertension. Histopathological and immunological features were consistent with the diagnosis of LPP that was managed by discontinuing captopril and corticosteroid therapy. Eight months after the cessation of oral steroid therapy, no relapse had occurred.


CONCLUSIONS
LPP, a rare skin disorder, has been generally considered to represent a mixture of clinical, histopathological and immunological patterns of lichen planus and bullous pemphigoid. It is predominantly idiopathic. However, in rare cases it has been associated with the administration of drugs. Here we present a typical LPP related to the use of captopril.


CONCLUSIONS
Clinicians should be aware of the ability of captopril to induce LPP.
Ben Salem
Chaker
C
Department of Clinical Pharmacology, Faculty of Medicine of Sousse, Tunisia.
Chenguel
Lilia
L
Ghariani
Najet
N
Denguezli
Mohamed
M
Hmouda
Houssem
H
Bouraoui
Kamel
K
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D002216:Captopril / Q000009:adverse effects*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008010:Lichen Planus / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D010391:Pemphigoid, Bullous / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology
D000806:Angiotensin-Converting Enzyme Inhibitors; D005938:Glucocorticoids; D002216:Captopril