Auditory brainstem response differences in diabetic and non-diabetic veterans.
A number of studies have found statistically significant delays in auditory brainstem latencies of patients with diabetes compared with non-diabetic controls. However, the mechanisms ascribed as responsible for the latency differences between diabetic and non-diabetic patients vary among studies, and the latency differences, while significant, are small. In this 5-year prospective study, auditory brainstem response testing was conducted with 416 non-diabetic and 375 diabetic veterans from the Portland Veterans Affairs Medical Center as part of a larger study. Patients with diabetes had significantly delayed latencies of Wave III and V in the right ear and significantly prolonged interpeak I-III and I-V latencies in both ears. Stimulus polarity difference yielded slightly different results. None of the diabetes-related clinical characteristics were associated with the latency differences between the subject groups after accounting for hearing loss and age. Effect size was calculated and clinical significance of these differences is discussed.
Vaughan
Nancy
N
VA National Center for Rehabilitative Auditory Research, Portland Veterans Affairs Medical Center, Portland, OR 97239, USA.
James
Kenneth
K
McDermott
Daniel
D
Griest
Susan
S
Fausti
Stephen
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001300:Audiometry, Evoked Response; D001301:Audiometry, Pure-Tone; D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D015897:Comorbidity; D003929:Diabetic Neuropathies / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged
D006442:Glycated Hemoglobin