title: Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women.
abstract: OBJECTIVE
  This study investigated the effects of Coleus Forskohlii (CF) on body composition, and determined the safety and efficacy of supplementation.
  
  
  METHODS
  In a double blind and randomized manner, 23 females supplemented their diet with ForsLeantrade mark (250 mg of 10% CF extract, (n = 7) or a placebo [P] (n = 12) two times per day for 12-wks. Body composition (DEXA), body weight, and psychometric instruments were obtained at 0, 4, 8 & 12 weeks of supplementation. Fasting blood samples and dietary records (4-d) were obtained at 0 and 12-wks. Side effects were recorded on a weekly basis. Data were analyzed by repeated measures ANOVA and are presented as mean changes from baseline for the CF and placebo groups, respectively.
  
  
  RESULTS
  No significant differences were observed in caloric or macronutrient intake. CF tended to mitigate gains in body mass (-0.7 +/- 1.8, 1.0 +/- 2.5 kg, p = 0.10) and scanned mass (-0.2 +/- 1.3, 1.7 +/- 2.9 kg, p = 0.08) with no significant differences in fat mass (-0.2 +/- 0.7, 1.1 +/- 2.3 kg, p = 0.16), fat free mass (-0.1 +/- 1.3, 0.6 +/- 1.2 kg, p = 0.21), or body fat (-0.2 +/- 1.0, 0.4 +/- 1.4%, p = 0.40). Subjects in the CF group tended to report less fatigue (p = 0.07), hunger (p = 0.02), and fullness (p = 0.04). No clinically significant interactions were seen in metabolic markers, blood lipids, muscle and liver enzymes, electrolytes, red cells, white cells, hormones (insulin, TSH, T3, and T4), heart rate, blood pressure, or weekly reports of side effects.
  
  
  CONCLUSIONS
  Results suggest that CF does not appear to promote weight loss but may help mitigate weight gain in overweight females with apparently no clinically significant side effects.
authors.affiliation: Exercise & Sport Nutrition Laboratory, Baylor University, Waco, TX.
authors.forename: Shonteh
authors.initials: S
authors.lastname: Henderson
authors.forename: Bahrat
authors.initials: B
authors.lastname: Magu
authors.forename: Chris
authors.initials: C
authors.lastname: Rasmussen
authors.forename: Stacey
authors.initials: S
authors.lastname: Lancaster
authors.forename: Chad
authors.initials: C
authors.lastname: Kerksick
authors.forename: Penny
authors.initials: P
authors.lastname: Smith
authors.forename: Charlie
authors.initials: C
authors.lastname: Melton
authors.forename: Patty
authors.initials: P
authors.lastname: Cowan
authors.forename: Mike
authors.initials: M
authors.lastname: Greenwood
authors.forename: Conrad
authors.initials: C
authors.lastname: Earnest
authors.forename: Anthony
authors.initials: A
authors.lastname: Almada
authors.forename: Pervis
authors.initials: P
authors.lastname: Milnor
authors.forename: Terri
authors.initials: T
authors.lastname: Magrans
authors.forename: Rodney
authors.initials: R
authors.lastname: Bowden
authors.forename: Song
authors.initials: S
authors.lastname: Ounpraseuth
authors.forename: Ashli
authors.initials: A
authors.lastname: Thomas
authors.forename: Richard B
authors.initials: RB
authors.lastname: Kreider