title: Extracorporeal shock waves as curative therapy for varicose veins?
abstract: In this prospective design study the effects of low-energy partially focused extracorporeal generated shock waves (ESW) onto a subcutaneous located varicose vein - left vena saphena magna (VSM)- are investigated. The treatment consisted of 4 ESW applications within 21 days. The varicose VSM of both sides were removed by surgery, and samples analyzed comparing the treated and untreated by means of histopathology. No damage to the treated varicose vein in particular and no mechanical destruction to the varicose vein's wall could be demonstrated. However, an induction of neo-collagenogenesis was observed. The thickness of the varicose vein's wall increased. Optimization of critical application parameters by investigating a larger number of patients may turn ESW into a non-invasive curative varicose treatment.
authors.affiliation: Klinik Piano, Biel, Switzerland. angehrn@klinikpiano.ch
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Angehrn
authors.forename: Christoph
authors.initials: C
authors.lastname: Kuhn
authors.forename: Ortrud
authors.initials: O
authors.lastname: Sonnabend
authors.forename: Axel
authors.initials: A
authors.lastname: Voss
mesh_terms: D005109:Extracellular Matrix; D019220:High-Energy Shock Waves / Q000627:therapeutic use*; D006801:Humans; D010991:Plethysmography; D014648:Varicose Veins / Q000473:pathology / Q000628:therapy*; D014680:Veins / Q000528:radiation effects