[Mild cognitive impairment and development of dementia].
OBJECTIVE
In order to identify mildly cognitively impaired subjects, MILD COGNITIVE IMPAIRMENT: (MCI) represents a current and well-discussed concept. Prevalence and conversion rates, relative risks and data on the sensitivity and specifity of MCI for the development of dementia will be calculated.


METHODS
980 subjects aged 75 years and over who participated in the Leipzig Longitudinal Study of the Aged (LEILA 75+) were clinically interviewed and cognitively tested at regularly intervals over a mean period of six years.


RESULTS
At baseline, the prevalence of MCI was 19.3 %, including (original) and 41.5 % excluding (modified) the criterion of subjective cognitive complaints. Diagnoses of original and modified amnestic MCI-subtypes were associated with relative risks of more than three for the development of dementia.


CONCLUSIONS
MCI represents a risk factor for dementia, mainly if the cognitive impairments are related to the area of memory. However, in order to predict dementia reliably, further findings (e. g. biomarkers) are required.
Luck
Tobias
T
Universität Leipzig, Zentrum für Psychische Gesundheit, Klinik und Poliklinik für Psychiatrie, Abteilung Public Health. Semmelweisstrasse 10, 04103 Leipzig. Tobias.Luck@medizin.uni-leipzig.de
Busse
Anja
A
Hensel
Anke
A
Angermeyer
Matthias C
MC
Riedel-Heller
Steffi G
SG
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000453:epidemiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000453:epidemiology; D009483:Neuropsychological Tests