In vitro hepatoprotective compounds from Suaeda glauca.
Bioassay-guided fractionation of the MeOH extract of Suaeda glauca yielded four phenolic compounds, methyl 3,5-di-O-caffeoyl quinate (1) and 3,5-di-O-caffeoyl quinic acid (2), isorhamnetin 3-O-beta-D-galactoside (3), and quercetin 3-O-beta-D-galactoside (4). Compounds 1 and 2 were hepatoprotective against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells with the EC(50) values of 72.7+/-6.2 and 117.2+/-10.5 microM, respectively. Silybin as a positive control showed an EC(50) value of 82.4+/-4.1 microM.
An
Ren-Bo
RB
College of Pharmacy, Yanbian University, Yanji, Jilin, 133000, China.
Sohn
Dong-Hwan
DH
Jeong
Gil-Saeng
GS
Kim
Youn-Chul
YC
D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor; D019663:Chenopodiaceae; D002726:Chlorogenic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D008113:Liver Neoplasms; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D013619:Tacrine / Q000633:toxicity
C525762:3,5-dicaffeoylquinic acid methyl ester; D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D002726:Chlorogenic Acid; D013619:Tacrine; C100434:3,5-dicaffeoylquinic acid