Chemical synthesis in nanosized cavities.
This account briefly discusses methods of in-cavity synthesis with the main focus on molecularly imprinted polymers and self-assembled capsules. Discussed are examples that highlight recent progress and outline key challenges for the further development of in-cavity synthesis. Emphasis is intentionally placed at potential applications in drug discovery and combinatorial technologies.
Patek
Marcel
M
Sanofi-Aventis Center for Combinatorial Technologies, Tucson, AZ 85737, USA. marcel.patek@sanofi-aventis.com
Drew
Mark
M
D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D054802:Molecular Imprinting; D053769:Nanocapsules / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D053769:Nanocapsules; D011108:Polymers