title: Sesquiterpenes from aerial parts of Ferula vesceritensis.
abstract: From the dichloromethane extract of aerial parts of Ferula vesceritensis (Apiaceae), 11 sesquiterpene derivatives were isolated. Among them five were compounds designated as 10-hydroxylancerodiol-6-anisate, 2,10-diacetyl-8-hydroxyferutriol-6-anisate, 10-hydroxylancerodiol-6-benzoate, vesceritenone and epoxy-vesceritenol. The six known compounds were identified as feselol, farnesiferol A, lapidol, 2-acetyl-jaeschkeanadiol-6-anisate, lasidiol-10-anisate and 10-oxo-jaesckeanadiol-6-anisate. All the structures were determined by extensive spectroscopic studies including 1D and 2D NMR experiments and mass spectroscopy analysis. Two of the compounds, the sesquiterpene coumarins farnesiferol A and feselol, bound to the model recombinant nucleotide-binding site of an MDR-like efflux pump from the enteropathogenic protozoan Cryptosporidium parvum.
authors.affiliation: Université de Lyon, UMR 5557 CNRS, Département de Pharmacognosie, Botanique et Phytothérapie, Faculté de Pharmacie, 8 Avenue Rockefeller, 69373 Lyon Cedex 08, France.
authors.forename: Karima
authors.initials: K
authors.lastname: Oughlissi-Dehak
authors.forename: Philippe
authors.initials: P
authors.lastname: Lawton
authors.forename: Serge
authors.initials: S
authors.lastname: Michalet
authors.forename: Christine
authors.initials: C
authors.lastname: Bayet
authors.forename: Nicole
authors.initials: N
authors.lastname: Darbour
authors.forename: Mahfoud
authors.initials: M
authors.lastname: Hadj-Mahammed
authors.forename: Yacine A
authors.initials: YA
authors.lastname: Badjah-Hadj-Ahmed
authors.forename: Marie-Geneviève
authors.initials: MG
authors.lastname: Dijoux-Franca
authors.forename: David
authors.initials: D
authors.lastname: Guilet
mesh_terms: D005309:Ferula / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry*
chemical_list: D012717:Sesquiterpenes