title: Primary small cell carcinoma of the breast.
abstract: Primary small cell carcinoma of the breast is a very rare disease, and only a few case reports have described small cell carcinoma of the breast that responds to chemotherapy. Here, we report a case of primary small cell carcinoma of the breast that was treated with surgery and chemotherapy for postoperative local recurrence in the chest wall and metastasis to the liver. The metastatic lesions showed a partial response (PR) to carboplatin and irinotecan, but did not respond to subsequent Taxotere and doxifluridine (5'-DFUR) treatment. We then treated the metastatic lesions with CBDCA and etoposide (VP-16), and were able to stop disease progression. Small cell carcinoma of the breast is as aggressive as its pulmonary counterpart. Therefore, the best therapy for primary small cell carcinoma of the breast may be surgery followed by adjuvant therapy similar to that recommended for small cell lung carcinoma.
authors.affiliation: Breast Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. tahojo@ncc.go.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Hojo
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Shien
authors.forename: Kotoe
authors.initials: K
authors.lastname: Terada
authors.forename: Shigemichi
authors.initials: S
authors.lastname: Hirose
authors.forename: You
authors.initials: Y
authors.lastname: Isobe
authors.forename: Shunji
authors.initials: S
authors.lastname: Ikeuchi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kubochi
authors.forename: Sumio
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Akashi-Tanaka
authors.initials: AT
authors.lastname: Sadako
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D016190:Carboplatin / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000473:pathology* / Q000628:therapy; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000628:therapy; D035441:Thoracic Wall / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D005047:Etoposide; D000077146:Irinotecan; D016190:Carboplatin; D002166:Camptothecin