pFlexAna: detecting conformational changes in remotely related proteins.
The pFlexAna (protein flexibility analyzer) web server detects and displays conformational changes in remotely related proteins, without relying on sequence homology. To do so, it first applies a reliable statistical test to align core protein fragments that are structurally similar and then clusters these aligned fragment pairs into 'super-alignments', according to the similarity of geometric transformations that align them. The result is that the dominant conformational changes occur between the clusters, while the smaller conformational changes occur within a cluster. pFlexAna is available at http://bigbird.comp.nus.edu.sg/pfa2/.
Nigham
Anshul
A
Department of Computer Science, National University of Singapore, Singapore 117590, Singapore-MIT Alliance, Singapore.
Tucker-Kellogg
Lisa
L
Mihalek
Ivana
I
Verma
Chandra
C
Hsu
David
D
D020407:Internet; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D012984:Software; D040681:Structural Homology, Protein; D000637:Transaminases / Q000737:chemistry; D044767:Ubiquitin-Protein Ligases / Q000737:chemistry; D014584:User-Computer Interface
D044767:Ubiquitin-Protein Ligases; D000637:Transaminases; C020656:glutamine-pyruvate aminotransferase