title: Total fundoplication controls acid and nonacid reflux: evaluation by pre- and postoperative 24-h pH-multichannel intraluminal impedance.
abstract: BACKGROUND
  Studies have demonstrated that Nissen fundoplication controls acid gastroesophageal reflux (GER). Combined 24-h pH and multichannel intraluminal impedance (MII-pH) allows detection of both acid and nonacid GER. Antireflux surgery is considered for any patient whose medical therapy is not efficient, particularly patients with nonacid gastroesophageal reflux disease (GERD). Nevertheless, fundoplication used to control nonacid reflux has not been reported to date.
  
  
  METHODS
  In this study, 15 consecutive patients who underwent laparoscopic Nissen-Rossetti fundoplication had MII-pH both before and after the surgical procedure. The numbers of acid and nonacid GER episodes were calculated with the patient in both upright and recumbent positions.
  
  
  RESULTS
  The 24-h pH monitoring confirmed the postoperative reduction of exposure to acid (p < 0.05). Postoperatively, the total, acid, and nonacid numbers of GER episodes were reduced (p < 0.05).
  
  
  CONCLUSIONS
  According to the findings, MII-pH is feasible and well tolerated. It provides an objective means for evaluating the effectiveness of Nissen-Rossetti fundoplication in controlling both acid and nonacid GER.
authors.affiliation: First Division of General and Gastrointestinal Surgery, Second University of Naples, via Pansini, 5, 80131, Naples, Italy. gdg@doctor.com
authors.forename: Gianmattia
authors.initials: G
authors.lastname: del Genio
authors.forename: Salvatore
authors.initials: S
authors.lastname: Tolone
authors.forename: Federica
authors.initials: F
authors.lastname: del Genio
authors.forename: Gianluca
authors.initials: G
authors.lastname: Rossetti
authors.forename: Luigi
authors.initials: L
authors.lastname: Brusciano
authors.forename: Francesco
authors.initials: F
authors.lastname: Pizza
authors.forename: Landino
authors.initials: L
authors.lastname: Fei
authors.forename: Alberto
authors.initials: A
authors.lastname: del Genio
mesh_terms: D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D017097:Electric Impedance; D050782:Esophageal pH Monitoring; D005260:Female; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011187:Posture / Q000502:physiology; D016896:Treatment Outcome