title: Enhancement of adipogenesis induction by conditioned media obtained from cancer cells.
abstract: White adipose tissue is a multifunctional endocrine organ that synthesizes and secretes cytokine-like proteins termed adipokines. In the present study, the effects of cancer-derived medium on adipogenesis were examined. We prepared conditioned media from cancer cell lines, and cultured preadipocytes in the conditioned media. After 10 days of culture, intracellular lipid droplet accumulation was measured. We observed that the conditioned media significantly induced adipogenesis or enhanced the adipogenesis induced by adipogenesis inducers. Although we could not define the factors, these undefined factors derived from cancer cells may induce adipogenesis, and the resulting adipogenesis may affect cancer development.
authors.affiliation: Graduate School of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka, Japan. t-hirano@env.kitakyu-u.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hirano
authors.forename: Haruki
authors.initials: H
authors.lastname: Morii
authors.forename: Koji
authors.initials: K
authors.lastname: Nakazawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Murakami
authors.forename: Akihisa
authors.initials: A
authors.lastname: Yamashita
authors.forename: Junpei
authors.initials: J
authors.lastname: Asahi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Orimo
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Tamae
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Tokura
mesh_terms: D050156:Adipogenesis; D002450:Cell Communication; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D017077:Culture Media, Conditioned; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000209:etiology
chemical_list: D017077:Culture Media, Conditioned