title: Mechanical stresses in carotid plaques using MRI-based fluid-structure interaction models.
abstract: Risk assessment in patients with carotid atherosclerosis relies on the degree of luminal stenosis. Incorporating morphological information on plaque composition obtained noninvasively through the use of magnetic resonance imaging (MRI) could include other variables besides the degree of stenosis into carotid plaque risk assessment. Knowledge of the morphologic composition of the plaque allows determination of mechanic stresses exerted on the protective fibrous cap, which may be of importance in the assessment of plaque vulnerability. Based on image processing of transverse MRI scans, longitudinal 2D fluid-structure interaction (FSI) simulations of carotid atherosclerotic plaques were performed facilitating in-vivo estimation of longitudinal internal fibrous cap stresses. The FSI simulation combined finite element analysis (FEA) with computational fluid dynamics (CFD) simulations of blood-flow variables. Preliminary results from two symptomatic patients revealed longitudinal stress levels (max. 254.1 and 143.2 kPa) approaching established criteria for plaque rupture at known predilection sites of plaque rupture. Determination of longitudinal fibrous cap stresses may prove useful in assessing plaque vulnerability and improve risk stratification in patients with carotid atherosclerosis.
authors.affiliation: MR-Center, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark. Samuel@mr.au.dk
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Kock
authors.forename: Jens V
authors.initials: JV
authors.lastname: Nygaard
authors.forename: Nikolaj
authors.initials: N
authors.lastname: Eldrup
authors.forename: Ernst-Torben
authors.initials: ET
authors.lastname: Fründ
authors.forename: Anette
authors.initials: A
authors.lastname: Klaerke
authors.forename: William P
authors.initials: WP
authors.lastname: Paaske
authors.forename: Erling
authors.initials: E
authors.lastname: Falk
authors.forename: W
authors.initials: W
authors.lastname: Yong Kim
mesh_terms: D000368:Aged; D001696:Biomechanical Phenomena; D002339:Carotid Arteries / Q000473:pathology*; D016893:Carotid Stenosis / Q000175:diagnosis* / Q000473:pathology; D020342:Finite Element Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008955:Models, Cardiovascular; D013314:Stress, Mechanical