Natural cyclopeptaibiotics and related cyclic tetrapeptides: structural diversity and future prospects.
Linearity is not considered a prerequisite anymore, and extension of the current definition of 'peptaibiotics' to cyclic, Aib-containing peptides is proposed. Sequences and bioactivities, together with ecophysiological importance of cyclopeptaibiotics and related cyclic tetrapeptides, and their fungal-taxonomic relationships, are discussed.
Degenkolb
Thomas
T
Interdisciplinary Research Centre (IFZ), Department of Food Sciences, Institute of Nutritional Science, University of Giessen, Giessen, Germany. thomas.degenkolb@ernaehrung.uni-giessen.de
Gams
Walter
W
Brückner
Hans
H
D000818:Animals; D006801:Humans; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D010456:Peptides, Cyclic