title: Antioxidant activity of Bol d'Air Jacquier breathing sessions in Wistar rats--first studies.
abstract: OBJECTIVE
  The Bol d'Air Jacquier is used to create a molecule able to deliver oxygen at the cellular level to manage hypoxia due to environmental pollution, ageing, or inflammatory disease. This study was designed to determine, firstly, whether the device generated oxidative stress and, secondly, whether it might induce an antioxidant effect.
  
  
  METHODS
  Over a period of 62 weeks, 10 male Wistar rats were randomized into two groups: the Bol d'Air group (BA) regularly breathed peroxidizing terpens delivered by the device and the control group breathed water vapour during 9-min sessions, at the frequency of 1-12 per month. Several antioxidant compounds and KRL levels were determined in the blood and major organs.
  
  
  RESULTS
  The results showed that the two groups did not differ with respect to the organ concentrations of Cu, Zn SOD, GPx, GSH, GSSG and TBARS. The device might have a weak slimming effect over time. The BA group presented a significantly higher GR level in plasma throughout the experiment, and in the muscle at the end of the study. In the BA group, the plasma Cu, Zn SOD level was related to the number of breathing sessions per week before blood collection. The BA group also had a higher KRLantioxidant status at two different time-points: at the onset of the study, in the blood of young rats; and after three breathing sessions per week, in the blood and RBCs of old rats.
  
  
  CONCLUSIONS
  The device did not generate oxidative stress and seemed to produce global antioxidant effect depending on the number of sessions per week, especially in old rats.
authors.affiliation: UPRES EA 4183 Lipides & Signalisation Cellulaire, Faculté des Sciences de la Vie, Dijon, France. beamercier@laposte.net
authors.forename: Béatrice
authors.initials: B
authors.lastname: Mercier
authors.forename: Josiane
authors.initials: J
authors.lastname: Prost
authors.forename: Michel
authors.initials: M
authors.lastname: Prost
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration
chemical_list: D000975:Antioxidants