title: [alpha1-adrenoceptor antagonists and ejaculation dysfunction].
abstract: alpha1-adrenoceptor antagonists are first-line agents for the treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia, while their adverse effects on sexual function are reported frequently in recent years, especially the induction of ejaculatory dysfunction. This review presents the distribution of alpha 1-adrenoceptors in the male genital system and the relationship of alpha1-adrenoceptors with ejaculatory function. It also highlights the interesting phenomenon of ejaculatory dysfunction related to these drugs and its possible mechanism, with the intention to provide some essential clues for further research on this problem as well as some references to safer use of these drugs in clinical settings.
authors.affiliation: Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. tankcy@163.com
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Qiang
authors.initials: Q
authors.lastname: Dong
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects* / Q000494:pharmacology; D004542:Ejaculation / Q000502:physiology*; D007172:Erectile Dysfunction / Q000139:chemically induced / Q000503:physiopathology*; D006801:Humans; D008297:Male; D018340:Receptors, Adrenergic, alpha-1 / Q000502:physiology*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D018340:Receptors, Adrenergic, alpha-1