T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't.
The mechanism behind the apparent lack of effective antiviral immune response in patients with chronic hepatitis C virus (HCV) infection is poorly understood. Although multiple levels of abnormalities have been identified in innate and adaptive immunity, it remains unclear if any of the subpopulations of T cells with regulatory capacity (Tregs) contribute to the induction and maintenance of HCV persistence. In this review, we summarize the current knowledge about Tregs as they relate to HCV infection.
Dolganiuc
Angela
A
Department of Medicine, University of Massachusetts Medical School, LRB 270J, 364 Plantation St., Worcester, MA 01605, USA. angela.dolganiuc@umassmed.edu
Szabo
Gyongyi
G
D000818:Animals; D016174:Hepacivirus / Q000276:immunology* / Q000472:pathogenicity; D006526:Hepatitis C / Q000276:immunology* / Q000821:virology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014758:Viral Core Proteins / Q000276:immunology
D014758:Viral Core Proteins