Molecular pathogenesis of head and neck cancers.
Head and neck cancers represent a progressive genetic malady, with genetic aberrations accumulating in response to carcinogen exposure. Although individual genomic aberrations develop at specific time points in the progression axis, the precise role of these abnormalities in tumor progression and cancer behavior remain to be elucidated. This article will give an overview of the current knowledge on the molecular basis for the development of head and neck cancers.
Singh
Bhuvanesh
B
Laboratory of Epithelial Cancer Biology, Head and Neck Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. singhb@mskcc.org
D000428:Alcohol Drinking / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000627:therapeutic use; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D030361:Papillomavirus Infections / Q000821:virology; D053918:Papillomavirus Vaccines; D012907:Smoking / Q000009:adverse effects; D016540:Smoking Cessation; D014412:Tumor Virus Infections / Q000821:virology
D000970:Antineoplastic Agents; D053918:Papillomavirus Vaccines; D066246:ErbB Receptors