title: Comparison of the ability of various pharmaceutical silicates to amorphize and enhance dissolution of indomethacin upon co-grinding.
abstract: The physical stability, dissolution rate, and solubility enhancement of indomethacin amorphized by co-grinding with 6 pharmaceutical silicates were investigated. Mixtures of indomethacin and silicates were co-ground to amorphous states at room temperature and 75% relative humidity (RH) in a rolling jar mill. The fraction of indomethacin amorphized was higher than would be expected for monolayer coverage on the silicate, suggesting additional stabilization of the amorphous drug in the mesopores of the silicate. The co-ground amorphous indomethacin was physically stable for 3 to 6 months at 40 degrees C/75% RH. The physicochemical properties (surface area, crystallinity, presence and absence of metal ions such as Mg(2+), Al(3+), Ca(2+)) of the silicates affect the amorphization time, chemical stability, dissolution, and solubility.
authors.affiliation: School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269, USA.
authors.forename: Deepak
authors.initials: D
authors.lastname: Bahl
authors.forename: John
authors.initials: J
authors.lastname: Hudak
authors.forename: Robin H
authors.initials: RH
authors.lastname: Bogner
mesh_terms: D017607:Aluminum Compounds; D000538:Aluminum Silicates / Q000737:chemistry*; D004339:Drug Compounding; D004355:Drug Stability; D004356:Drug Storage; D005079:Excipients / Q000737:chemistry; D006813:Humidity; D007213:Indomethacin / Q000008:administration & dosage* / Q000737:chemistry*; D007616:Kaolin; D007700:Kinetics; D008274:Magnesium / Q000737:chemistry*; D017616:Magnesium Compounds; D008670:Metals / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D010316:Particle Size; D010592:Pharmaceutic Aids; D016062:Porosity; D017640:Silicates / Q000737:chemistry*; D012995:Solubility; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D017607:Aluminum Compounds; D000538:Aluminum Silicates; D005079:Excipients; D017616:Magnesium Compounds; D008670:Metals; D010592:Pharmaceutic Aids; D017640:Silicates; D007616:Kaolin; C033065:aluminum magnesium silicate; D008274:Magnesium; D007213:Indomethacin