Maturation-dependent sensitivity of oligodendrocyte lineage cells to apoptosis: implications for normal development and disease.
Apoptosis plays a crucial role in brain development by ensuring that only appropriately growing, migrating, and synapse-forming neurons and their associated glial cells survive. This process involves an intimate relationship between cell-cell interactions and developmental cues and is further impacted by environmental stress during neurogenesis and disease. Oligodendrocytes (OLs), the major myelin-forming cells in the central nervous system, largely form after this wave of neurogenesis but also show a selective vulnerability to cell death stimuli depending on their stage of development. This can affect not only embryonic and early postnatal brain formation but also the response to demyelinating pathologies. In the present review, we discuss the stage-specific sensitivity of OL lineage cells to damage-induced death and how this might impact myelin survival and regeneration during injury or disease.
Butts
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BD
Apoptosis Research Group, Merck Research Laboratories, RY80Y-215, 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
Houde
C
C
Mehmet
H
H
D000544:Alzheimer Disease / Q000473:pathology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D017209:Apoptosis; D001927:Brain Diseases / Q000473:pathology; D002454:Cell Differentiation; D019070:Cell Lineage; D002470:Cell Survival; D002490:Central Nervous System / Q000196:embryology / Q000378:metabolism / Q000473:pathology*; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D009103:Multiple Sclerosis / Q000473:pathology; D009186:Myelin Sheath / Q000378:metabolism; D009836:Oligodendroglia / Q000378:metabolism / Q000473:pathology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012559:Schizophrenia / Q000473:pathology
D000975:Antioxidants; D017382:Reactive Oxygen Species; D018698:Glutamic Acid