Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal.
When stem cells divide, they can generate progeny with the same developmental potential as the original cell, a process referred to as self-renewal. Self-renewal is driven intrinsically by gene expression in a cell-type-specific manner and is modulated through interactions with extrinsic cues from the environment, such as growth factors. However, despite the prevalence of the term self-renewal in the scientific literature, this process has not been defined at the molecular level. Haematopoietic stem cells are an excellent model for the study of self-renewal because they can be isolated prospectively, manipulated relatively easily and assessed by using well-defined assays. Establishing the principles of self-renewal in haematopoietic stem cells will lead to insights into the mechanisms of self-renewal in other tissues.
Zon
Leonard I
LI
Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Karp 7, 1 Blackfan Circle, Boston, Massachusetts 02115, USA. zon@enders.tch.harvard.edu
D000818:Animals; D044127:Epigenesis, Genetic; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D012038:Regeneration / Q000187:drug effects / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects
D018398:Homeodomain Proteins