Perception of phosphenes and flashed alphabetical characters is enhanced by single-pulse transcranial magnetic stimulation of anterior frontal lobe: the thalamic gate hypothesis.
Single pulses of transcranial magnetic stimulation (sTMS) restricted locally to the primary cortical areas for somatosensory and visual input, unlike the effects of repetitive stimulation, usually fail to elicit projected sensations. We tested the effect of sTMS over anterior frontal cortex in facilitating phosphenes from preceding sTMS over calcarine cortex, which alone was rarely effective in eliciting phosphenes. The combined sTMS elicited complex phosphenes, which changed with the site of frontal sTMS and the interstimulus interval. Our results show that sTMS over anterior frontal cortex also improved reporting of weakly illuminated, flashed four-letter stimuli, which permitted its statistical validation. We propose that the present demonstration of frontal cortical facilitation of visual awareness, when combined with the previous finding of projected paresthesias and sense of movement (Amassian et al, 1991 Brain 114 2505-2520), provide evidence of a general frontal opening effect on a thalamic gate. Opening this gate facilitates entry of information from primary cortical receiving areas to thalamus. Thereby, the reciprocal thalamocortical interrelations that subserve conscious awareness of sensory stimuli could be fostered.
Amassian
Vahe
V
Department of Neurology, Downstate Medical Center, State University of New York, 450 Clarkson Avenue, Brooklyn, NY 11201, USA.
Mari
Zoltan
Z
Sagliocco
Laura
L
Hassan
Nasser
N
Maccabee
Peter
P
Cracco
Joan B
JB
Cracco
Roger Q
RQ
Bodis-Wollner
Ivan
I
D000328:Adult; D000368:Aged; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008960:Models, Psychological; D009068:Movement / Q000502:physiology; D010719:Phosphenes / Q000502:physiology*; D010775:Photic Stimulation; D013788:Thalamus / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation / Q000295:instrumentation / Q000379:methods*; D014796:Visual Perception / Q000502:physiology*