Erythropoietin and the endothelium - a promising link?
The major physiological function of erythropoietin (EPO) is thought to be the induction of erythropoiesis. However, a growing body of evidence indicates that EPO as well as recombinant human erythropoietin (rHuEPO) and its analogues have tissue-protective effects and prevent tissue damage during ischaemia. This mini review summarizes the present knowledge on protective vascular effects of EPO and discusses the potential underlying mechanisms.
Fliser
D
D
Saarland University Medical Centre, Homburg, Germany. indfli@uks.eu
Bahlmann
F H
FH
D002454:Cell Differentiation / Q000502:physiology*; D042783:Endothelial Cells / Q000378:metabolism*; D004727:Endothelium / Q000378:metabolism*; D004921:Erythropoietin / Q000378:metabolism*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D017467:Receptors, Erythropoietin / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D014652:Vascular Diseases / Q000378:metabolism / Q000517:prevention & control*
D017467:Receptors, Erythropoietin; D004921:Erythropoietin; D009569:Nitric Oxide; D017346:Protein Serine-Threonine Kinases