Impact of delays in cell infection and virus production on HIV-1 dynamics.
Analysed is a mathematical model for HIV-1 infection with two delays accounting, respectively, for (i) a latent period between the time target cells are contacted by the virus particles and the time the virions enter the cells and (ii) a virus production period for new virions to be produced within and released from the infected cells. For this model, the basic reproduction number is identified and its threshold property is discussed: the uninfected steady state is proved to be globally asymptotically stable if and unstable if . In the latter case, an infected steady state occurs and is proved to be locally asymptotically stable. The formula for shows that increasing either of the two delays will decrease . This may suggest a new direction for new drugs-drugs that can prolong the latent peri od and/or slow down the virus production process.
Zhu
Huiyan
H
School of Mathematics and Physics, Nanhua University, Hengyang, Hunan 421001, People's Republic of China.
Zou
Xingfu
X
D050936:Basic Reproduction Number; D003198:Computer Simulation; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D017735:Virus Latency; D014779:Virus Replication