Thrombin activatable fibrinolysis inhibitor in preeclampsia and gestational hypertension throughout the gestation.
To clarify the role of TAFI in hypertensive disorders in pregnancy, 22 subjects, including 10 with pre-eclampsia (PE) and 12 with gestational hypertension were examined for the levels of TAFI and thrombin-antithrombin (TAT) complex. Thirty normal pregnant women served as controls. ELISA was employed for the detection. The results showed that the TAFI antigen levels in normal pregnancy group, gestational hypertension group and PE group were (85.35+/-24.69)%, (99.65+/-18.27)%, (110.12+/-23.36)%; (97.06+/-21.40)%, (114.08+/-27.76)%, (125.49+/-24.70)%; (106.6+/-19.21)%, (129.2+/-25.07)%, (139.1+/-30.12)%, in the 1st, 2nd and 3rd trimester respectively. No significant differences were found between the normal pregnancy group and gestational hypertension group but significant difference existed between normal pregnancy group and PE group in each trimester (P<0.05). TAT complexes were significantly higher in patients with PE than that in controls (P<0.05), but no correlation was found between TAT and TAFI. It is concluded that TAFI may contributed to the impairment of fibrinolysis in the patients with PE and may serves as a sensitive indicator for PE, but it may not help in the diagnosis of the gestational hypertension.
Zhang
Yinghong
Y
The Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Hu
Yu
Y
Guo
Tao
T
Wei
Wenning
W
Zhang
Xiaoping
X
D000328:Adult; D000941:Antigens / Q000737:chemistry; D000990:Antithrombin III / Q000378:metabolism; D000991:Antithrombins / Q000737:chemistry; D025901:Carboxypeptidase B2 / Q000494:pharmacology*; D005260:Female; D005342:Fibrinolysis; D005786:Gene Expression Regulation; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000378:metabolism; D011264:Pregnancy Trimesters; D013917:Thrombin / Q000737:chemistry
D000941:Antigens; D000991:Antithrombins; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases; D025901:Carboxypeptidase B2; D013917:Thrombin