title: Artificial circulation of the liver: machine perfusion as a preservation method in liver transplantation.
abstract: Due to the sharp increase in liver transplant candidates and the subsequent shortage of suitable donor livers, an extension of the current donor criteria is necessary. Simple cold storage, the current standard in organ preservation has proven to be insufficient to preserve extended criteria donor livers. Therefore a renewed interest grew toward alternative methods for liver preservation, such as hypothermic machine perfusion and normothermic machine perfusion. These "new" preservation methods were primarily assessed in rat models, and only a few clinically relevant large animal models have been described so far. This review will elaborate on these alternative preservation methods.
authors.affiliation: Abdominal Transplant Surgery, Catholic University of Leuven (KULeuven), Leuven, Belgium. katrien.vekemans@med.kuleuven.be
authors.forename: Katrien
authors.initials: K
authors.lastname: Vekemans
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Jacques
authors.initials: J
authors.lastname: Pirenne
authors.forename: Diethard
authors.initials: D
authors.lastname: Monbaliu
mesh_terms: D000818:Animals; D004285:Dogs; D006801:Humans; D008102:Liver Circulation; D016031:Liver Transplantation / Q000379:methods*; D023421:Models, Animal; D009926:Organ Preservation / Q000295:instrumentation / Q000379:methods*; D019188:Organ Preservation Solutions; D010477:Perfusion / Q000295:instrumentation / Q000379:methods; D011817:Rabbits; D051381:Rats; D034421:Sus scrofa; D013696:Temperature
chemical_list: D019188:Organ Preservation Solutions