Risk factors for osteoporosis and bone status in postmenopausal women with psoriasis treated with UVB therapy.
The aims of this study were to examine whether postmenopausal women with psoriasis who were exposed to regular ultraviolet light B (UVB) therapy had greater bone mineral density than women of similar age from the same region, and to estimate the influence of risk factors on bone status. A total of 35 randomly selected women, age (mean +/- SD) 69.3 +/- 6.29 years (age range 60-82 years), with active psoriasis, mean onset at 37.0 years (+/- 23.5 SD) were studied. The patients had been previously exposed to broadband or narrowband UVB. Age-matched, women (n = 2448) from Göteborg, examined at the Geriatric out-patient clinic during the years 2001 and 2002, were used as controls. Bone mineral density was examined by Dual-Energy X-ray Absorptiometry (Hologic Delphi A) at the hip and the lumbar spine. Medical history and lifestyle factors were assessed with a questionnaire. Postmenopausal women with psoriasis were found to have higher bone mineral density than age-matched controls. Higher body weight, physical activity and UVB exposure could explain this finding.
Osmancevic
Amra
A
Department of Dermatology, Sahlgrenska University Hospital, Göteborg, Sweden. Amra.Osmancevic@vgregion.se
Landin-Wilhelmsen
Kerstin
K
Larkö
Olle
O
Mellström
Dan
D
Wennberg
Ann-Marie
AM
Hulthén
Lena
L
Krogstad
Anne-Lene
AL
D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D001835:Body Weight; D015519:Bone Density; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism / Q000453:epidemiology / Q000628:therapy; D008875:Middle Aged; D009043:Motor Activity; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology*; D010298:Parity; D017698:Postmenopause; D011247:Pregnancy; D011565:Psoriasis / Q000453:epidemiology / Q000628:therapy*; D012307:Risk Factors; D013472:Sunlight; D013548:Sweden / Q000453:epidemiology; D014467:Ultraviolet Therapy