title: Hypoglycemia associated with the production of insulin-like growth factor II in a pancreatic islet cell tumor: a case report.
abstract: An insulinoma is characterized by endogenous hyperinsulinemia and hypoglycemia. However, it has been reported that insulinomas with normal levels of plasma insulin and a normal insulin to glucose ratio occur in patients with hypoglycemia. Although overproduction of Insulin-like growth factor II (IGF-II) by non-islet cell tumors such as large mesenchymal tumors, can cause hypoglycemia, no cases of circulating plasma IGF-II from an islet cell tumor contributing to hypoglycemia have been reported. We report here a rare case of a pancreatic islet tumor in a patient with hypoglycemia that was associated with increased plasma IGF-II, which returned to normal after tumor resection.
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Jin Ook
authors.initials: JO
authors.lastname: Chung
authors.forename: Se In
authors.initials: SI
authors.lastname: Hong
authors.forename: Dong Hyeok
authors.initials: DH
authors.lastname: Cho
authors.forename: Jae Hyuk
authors.initials: JH
authors.lastname: Lee
authors.forename: Dong Jin
authors.initials: DJ
authors.lastname: Chung
authors.forename: Min Young
authors.initials: MY
authors.lastname: Chung
mesh_terms: D000368:Aged; D018273:Carcinoma, Islet Cell / Q000097:blood / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology* / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D007515:Islets of Langerhans / Q000378:metabolism* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000097:blood / Q000150:complications* / Q000378:metabolism / Q000601:surgery
chemical_list: C035170:IGF2 protein, human; D007335:Insulin-Like Growth Factor II