Ventilation strategies and adjunctive therapy in severe lung disease.
Respiratory failure caused by severe lung disease is a common reason for admission to the pediatric and neonatal intensive care units. Efforts to decrease morbidity and mortality have fueled investigations into innovative methods of ventilation, kinder gentler ventilation techniques, pharmacotherapeutic adjuncts, and extracorporeal life support modalities. This article discusses the rationale for and experience with some of these techniques.
Kissoon
Niranjan
N
Department of Pediatrics, University of British Columbia, Children's Hospital, Room K4-105, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada. nkissoon@cw.bc.ca
Rimensberger
Peter C
PC
Bohn
Desmond
D
D000280:Administration, Inhalation; D002648:Child; D005112:Extracorporeal Circulation / Q000592:standards*; D016166:Free Radical Scavengers / Q000008:administration & dosage; D006371:Helium / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D008171:Lung Diseases / Q000401:mortality / Q000628:therapy*; D009569:Nitric Oxide / Q000008:administration & dosage*; D010100:Oxygen / Q000008:administration & dosage / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic; D012121:Respiration, Artificial / Q000592:standards*; D012720:Severity of Illness Index; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome
D016166:Free Radical Scavengers; D006371:Helium; D009569:Nitric Oxide; C038949:heliox; D010100:Oxygen