title: Metabolism of hibernating myocardium assessed by microdialysis during surgical revascularization: report of a case.
abstract: We present an 80-year-old woman with hibernating myocardium in the left anterior descending coronary artery (LAD) territory who underwent surgical revascularization and metabolic evaluation of the dysfunctioning segments by microdialysis (microD) technique. Myocardial lactate, pyruvate, and glucose did not show obvious changes throughout the procedure. Conversely, myocardial glycerol and glutamate concentrations markedly increased early after cardioplegic arrest and subsided after weaning from cardiopulmonary bypass (CPB) and recovery of myocardial function. Intraoperative myocardial microD may add relevant pathophysiologic information on hibernating myocardium undergoing coronary flow restoration and, eventually, improve patient care.
authors.affiliation: Department of Anesthesia and Intensive Care, Humanitas Gavazzeni, Bergamo, Lombardy, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Mazzoni
authors.forename: Franco
authors.initials: F
authors.lastname: Bortone
authors.forename: Roberto
authors.initials: R
authors.lastname: Ceriani
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Caprioli
authors.forename: Bruno
authors.initials: B
authors.lastname: Passaretti
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Arena
authors.forename: Oberdan
authors.initials: O
authors.lastname: Parodi
mesh_terms: D000369:Aged, 80 and over; D002315:Cardiopulmonary Bypass; D005260:Female; D006324:Heart Arrest, Induced; D006801:Humans; D017551:Microdialysis; D016343:Monitoring, Intraoperative; D009204:Myocardial Revascularization; D017682:Myocardial Stunning / Q000378:metabolism* / Q000601:surgery; D009206:Myocardium / Q000378:metabolism*