S100 calgranulin proteins S100A8, S100A9 and S100A12 are expressed in the inflamed gastric mucosa of Helicobacter pylori-infected children.
The expression of the inflammatory S100 calgranulin proteins (S100A8, S100A9 and S100A12) in normal and Helicobacter pylori-infected gastric mucosa of children were examined. S100A8, S100A9 and S100A12, which were virtually absent in normal gastric mucosa, were highly expressed in H pylori-infected mucosa. This expression correlated with the severity of gastritis (r=0.9422, P<0.05). S100 calgranulins may be involved in bacterial-induced gastritis and may limit bacterial growth.
Leach
Steven T
ST
School of Women's and Children's Health, University of New South Wales, Sydney, Australia. s.leach@unsw.edu.au
Mitchell
Hazel M
HM
Geczy
Carolyn L
CL
Sherman
Philip M
PM
Day
Andrew S
AS
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D016145:Endoscopy, Digestive System; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D005756:Gastritis / Q000378:metabolism* / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000378:metabolism* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D009418:S100 Proteins / Q000378:metabolism*; D012720:Severity of Illness Index
D009418:S100 Proteins