title: Interaction effects between total energy and macronutrient intakes and angiotensin-converting enzyme 1 ( ACE) I/D polymorphism on adiposity-related phenotypes in toddlers and preschoolers: the Growth, Exercise and Nutrition Epidemiological Study in preSchoolers: the GENESIS study. [corrected].
abstract: The aim of the present study was to investigate the interaction between the angiotensin-converting enzyme 1 (ACE) I/D polymorphism and energy and macronutrient intakes on adiposity-related phenotypes among toddlers and preschoolers. A representative sample of 2374 Greek children aged 1 to 5 years old was examined (Growth, Exercise and Nutrition Epidemiological Study in preSchoolers (GENESIS)). Dietary and anthropometric (i.e. BMI, waist circumference (WC)) assessments were carried out using standard procedures. DNA samples were obtained from 2102 children and were genotyped for the ACE I/D polymorphism. Among the entire population, 17 % were 'at risk of overweight' and a similar percentage were 'overweight'. The frequencies of the II, ID and DD genotypes were 16, 46 and 38 %, respectively. Significant interactions were found between the ACE I/D polymorphism and total energy intake on WC (P = 0.004 for interaction) and the ACE I/D polymorphism and protein intake on BMI and being overweight (P < 0.05 for interaction). Furthermore, it was found that the ACE I/D polymorphism may modify the effect of fat intake on WC and BMI, but this interaction disappeared after adjustment for additional potential confounders. Stratified analyses revealed that total energy is correlated with WC and protein intake is associated with BMI and being overweight only among carriers of the D-allele (i.e. DD or ID genotypes). These results suggest that the ACE I/D polymorphism may act as a modifying factor in the response of adiposity-related phenotypes to diet.
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University of Athens, 70 El. Venizelou Ave, Kallithea 17671, Athens, Greece.
authors.forename: Georgia
authors.initials: G
authors.lastname: Kourlaba
authors.forename: Yannis P
authors.initials: YP
authors.lastname: Pitsiladis
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Lagou
authors.forename: Evangelia
authors.initials: E
authors.lastname: Grammatikaki
authors.forename: Colin N
authors.initials: CN
authors.lastname: Moran
authors.forename: Katerina
authors.initials: K
authors.lastname: Kondaki
authors.forename: Eleytheria
authors.initials: E
authors.lastname: Roma-Giannikou
authors.forename: Yannis
authors.initials: Y
authors.lastname: Manios
mesh_terms: D050154:Adiposity / Q000235:genetics* / Q000502:physiology; D000886:Anthropometry / Q000379:methods; D015992:Body Mass Index; D002664:Child Nutritional Physiological Phenomena / Q000235:genetics* / Q000502:physiology; D002675:Child, Preschool; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D007703:Peptidyl-Dipeptidase A