title: [Refractory sprue--precursor lesion of enteropathy type T-cell lymphoma--a clinicopathological case report].
abstract: BACKGROUND
  Refractory sprue is characterised by distinctive morphologic alterations and the emergence of clonal intraepithelial lymphocytes.
  
  
  OBJECTIVE
  In this case report the authors emphasize the importance of histopathology in the diagnosis of refractory sprue.
  
  
  METHODS
  The sequential biopsies from this patient have been investigated with routine histology, immunohistochemistry and molecular genetics for T-cell clonality analysis.
  
  
  RESULTS
  The severely cachectic patient presenting with malabsorption syndrome has been diagnosed with celiac disease through a duodenal biopsy, and the CD8 negativity of the intraepithelial lymphocytes suggested the possible diagnosis of refractory sprue. Azathioprine and glucocorticoid therapy was administered due to the failed jejunal feeding and gluten-free diet, resulting in clinically complete, morphologically partial remission. Intestinal T-cell lymphoma developed in the ileocecal region within two years after the first clinical presentation.
  
  
  CONCLUSIONS
  Refractory sprue and the enteropathy-type T-cell lymphoma constitute a disease spectrum. The reported case shows how a simple method can provide crucial information in the diagnosis of refractory sprue.
authors.affiliation: Daganatpatológiai és Molekuláris Diagnosztikai Laboratórium, Szeged.
authors.forename: Eniko
authors.initials: E
authors.lastname: Bagdi
authors.forename: József
authors.initials: J
authors.lastname: Kiss
authors.forename: Zita
authors.initials: Z
authors.lastname: Borbényi
authors.forename: Klára
authors.initials: K
authors.lastname: Piukovics
authors.forename: László
authors.initials: L
authors.lastname: Krenács
mesh_terms: D000368:Aged; D001706:Biopsy; D002430:Cecal Neoplasms / Q000150:complications / Q000473:pathology; D002446:Celiac Disease / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications / Q000473:pathology; D007150:Immunohistochemistry; D007414:Intestinal Neoplasms / Q000150:complications* / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000473:pathology*