title: Pre-operative DTI and probabilisitic tractography in four patients with deep brain stimulation for chronic pain.
abstract: This study aimed to examine, using diffusion tensor imaging (DTI), differences in electrode placement in four patients undergoing deep brain stimulation for chronic neuropathic pain of varying aetiology. A pre-operative DTI was obtained for each patient, who was then implanted with deep brain stimulation electrodes in the periventricular/periaqueductal grey area with good pain relief. Using seeds from the postoperative MRI scan, probabilistic tractography was performed from the pre-operative DTI.
authors.affiliation: Oxford Functional Neurosurgery, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. sarah.owen@physiology.ox.ac.uk
authors.forename: S L F
authors.initials: SL
authors.lastname: Owen
authors.forename: J
authors.initials: J
authors.lastname: Heath
authors.forename: M
authors.initials: M
authors.lastname: Kringelbach
authors.forename: A L
authors.initials: AL
authors.lastname: Green
authors.forename: E A C
authors.initials: EA
authors.lastname: Pereira
authors.forename: N
authors.initials: N
authors.lastname: Jenkinson
authors.forename: T
authors.initials: T
authors.lastname: Jegan
authors.forename: J F
authors.initials: JF
authors.lastname: Stein
authors.forename: T Z
authors.initials: TZ
authors.lastname: Aziz
mesh_terms: D001931:Brain Mapping / Q000379:methods; D002908:Chronic Disease; D046690:Deep Brain Stimulation / Q000295:instrumentation / Q000379:methods*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D004567:Electrodes, Implanted; D006801:Humans; D015233:Models, Statistical; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology / Q000601:surgery; D010148:Intractable Pain / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D010487:Periaqueductal Gray / Q000033:anatomy & histology / Q000502:physiology / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control; D011300:Preoperative Care / Q000295:instrumentation / Q000379:methods*; D013238:Stereotaxic Techniques / Q000295:instrumentation*