Effect of experimentally induced hypoglycemia and different insulin levels on feelings of hunger in type 1 diabetic patients.
BACKGROUND
This study investigates the impacts of experimentally induced hypoglycemia and different insulin infusion rates on feelings of hunger.


METHODS
Blood glucose and insulin levels were manipulated by hyperinsulinemic glucose clamp technique. Participants were 16 patients with type 1 diabetes (age 36.2+/-11.7 yrs, diabetes duration 9.0+/-6.3 yrs, HbA1c 8.2+/-2.0%). One group (n=8) received moderate, constant insulin infusion (0.8 microU/kg/min), whereas the insulin infusion was doubled in the other group (1.6 microU/kg/min). Blood glucose was lowered stepwise from euglycemia (5.6 mmol/l) to moderate hypoglycemia (2.5 mmol/l).


RESULTS
As expected, there was a significant effect of hypoglycemia on feelings of hunger (F (3, 42)=41.7, p<0.01). But during high insulin infusion, feelings of hunger were significantly less intense than during moderate insulin infusion (F (1, 14)=7.2, p=0.02).


CONCLUSIONS
Peripheral insulin levels seem to be associated with the intensity of feelings of hunger.
Hermanns
N
N
Research institute of the Diabetes Academy Mergentheim, Germany. Hermanns@diabetes-zentrum.de
Plate
M
M
Kulzer
B
B
Fischer
B
B
Linn
T
T
Bretzel
R
R
Haak
T
T
D000328:Adult; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D004703:Endocrine System / Q000503:physiopathology; D005260:Female; D006801:Humans; D006815:Hunger / Q000187:drug effects*; D007003:Hypoglycemia / Q000139:chemically induced* / Q000503:physiopathology; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D007328:Insulin