The oxa-Michael reaction: from recent developments to applications in natural product synthesis.
In marked contrast to Michael reactions, oxa-Michael reactions have not been used as standard transformations in organic synthesis until quite recently. This was mainly due to a lack of reactivity and selectivity, although the potential products of such reactions are valuable intermediates. This tutorial review presents recent major advances in the field of oxa-Michael (sometimes called oxo-Michael or oxy-Michael) reactions and applications in the total synthesis of complex natural products.
Nising
Carl F
CF
Bayer Cropscience AG, Alfred-Nobel-Strasse 50, D-40789 Monheim am Rhein, Germany. carlfriedrich.nising@bayercropscience.com
Bräse
Stefan
S
D001685:Biological Factors / Q000138:chemical synthesis* / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D008968:Molecular Conformation; D010100:Oxygen / Q000737:chemistry*; D013237:Stereoisomerism
D001685:Biological Factors; D006571:Heterocyclic Compounds; D010100:Oxygen