title: Clinical implications of idiopathic multicentric castleman disease among Japanese: a report of 28 cases.
abstract: To clarify the clinicopathologic findings of idiopathic multicentric Castleman disease among Japanese, 28 cases were studied. Two variants were delineated by the clinicopathologic findings (1) idiopathic plasmacytic lymphadenopathy with polyclonal hyperimmunoglobulinemia (n = 18) and (2) nonidiopathic plasmacytic lymphadenopathy type (n= 10). Clinicopathologically, idiopathic plasmacytic lymphadenopathy was defined by the prominent polyclonal hyperimmunoglobulinemia, normal germinal centers, and sheet-like infiltration of plasma cells in the interfollicular area of the lymph node. Histologically, the nonidiopathic plasmacytic lymphadenopathy type was characterized by hyaline-vascular germinal centers of the lymph node lesion. In comparison with idiopathic plasmacytic lymphadenopathy, patients with nonidiopathic plasmacytic lymphadenopathy showed infrequent prominent polyclonal hyperimmunoglobulinemia and frequent association with autoimmune disease. However, there was no difference in the overall 5-year survival between the 2 subtypes. Compared with idiopathic multicentric Castleman disease in Western countries, the chronic course of the disease of idiopathic multicentric Castleman disease in Japan appears to be related to negativity for human herpesvirus 8 infection.
authors.affiliation: Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta, Japan. mkojima@gunma-cc.jp
authors.forename: Masaru
authors.initials: M
authors.lastname: Kojima
authors.forename: Naoya
authors.initials: N
authors.lastname: Nakamura
authors.forename: Norihumi
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Otuski
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Shimizu
authors.forename: Hideaki
authors.initials: H
authors.lastname: Itoh
authors.forename: Satsuki
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Takuhei
authors.initials: T
authors.lastname: Murase
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Masawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Kashimura
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D005871:Castleman Disease / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged