Complexes with biologically active ligands. Part 9 metal complexes of 5-benzoylamino- and 5-(3-nitrobenzoyl-amino)-1,3,4-thiadiazole-2-sulfonamide as carbonic anhydrase inhibitors.
Complexes containing the anions of 5-benzoylamido-1,3,4-thiadiazole-2-sulfonamide and 5-(3-nitro-benzoylamido)-1,3,4-thiadiazole-2-sulfonamid as ligands, and V(IV); Cr(III); Fe(III); Co(II); Ni(II); Cu(II) and Ag(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic, and EPR spectroscopy; TG, magnetic and conductimetric measurements). The original sulfonamides and their metal complexes are strong inhibitors of two carbonic anhydrase (CA) isozymes, CA I and II.
Jitianu
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"I.G. Murgulescu" Institute of Physical Chemistry Spl. Independentei, 202 Bucharest R-77208 Romania.
Llies
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Briganti
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Scozzafava
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Supuran
C T
CT