title: [Safety and efficacy analysis of FOLFOX4 regimen in elderly compared to younger colorectal cancer patients].
abstract: The number of elderly patients with colorectal cancer is increasing in Japan. They have the opportunity to receive chemotherapy similar to non-elderly patients because of the development of new drug agents and improvement of supportive therapy. We analyzed retrospectively 184 patients (32 aged >or= 70, 75 <or=) with advanced and metastatic colorectal cancer with good performance status who received FOLFOX4 regimen between April 2005 and March 2006. We observed adverse events, time to treatment failure, response rate, reason to discontinue treatment, and dose intensity. Age <or= 70 was associated with slightly higher rates of neutropenia but no other grade >or= 3 adverse events. The FOLFOX4 regimen maintains its efficacy/safety ratio in elderly patients with good performance status with colorectal cancer in Japan.
authors.affiliation: Dept. of Chemotherapy, Cancer Institute Ariake Hospital.
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Kuboki
authors.forename: Takashi
authors.initials: T
authors.lastname: Ichimura
authors.forename: Mariko
authors.initials: M
authors.lastname: Ogura
authors.forename: Masanori
authors.initials: M
authors.lastname: Matsuda
authors.forename: Mitsukuni
authors.initials: M
authors.lastname: Suenaga
authors.forename: Eiji
authors.initials: E
authors.lastname: Shinozaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Matsuzaka
authors.forename: Keisho
authors.initials: K
authors.lastname: Chin
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Mizunuma
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Hatake
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil