title: Acid cleavable PEG-lipids for applications in a ternary gene delivery vector.
abstract: A novel class of pH-sensitive PEG lipids bearing acid-cleavable acetal linkages and short PEG chains have been synthesised and used in ternary vector formulations. The cleavage pH was influenced by structural components including the terminal PEG moiety and spacer length.
authors.affiliation: Department of Chemistry, University College London, 20 Gordon Street, London, UK.
authors.forename: John B
authors.initials: JB
authors.lastname: Wong
authors.forename: Stephanie
authors.initials: S
authors.lastname: Grosse
authors.forename: Alethea B
authors.initials: AB
authors.lastname: Tabor
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Hart
authors.forename: Helen C
authors.initials: HC
authors.lastname: Hailes
mesh_terms: D000143:Acids / Q000737:chemistry*; D002478:Cells, Cultured; D004247:DNA / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D018014:Gene Transfer Techniques; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000138:chemical synthesis / Q000737:chemistry* / Q000235:genetics; D015394:Molecular Structure; D010957:Plasmids / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D014162:Transfection
chemical_list: D000143:Acids; D004337:Drug Carriers; D008055:Lipids; D011092:Polyethylene Glycols; D004247:DNA