title: A case report of a patient with dermatomyositis as a prodromal sign of lung cancer.
abstract: Dermatomyositis (DM) is a connective tissue disease characterized by specific inflammatory lesions in muscle biopsy. It is caused by vasculitis determined by humoral factors with subsequent inflammatory cell accumulation, mainly T CD4+ and B cells, which infiltrate myocytes leading to its vacuolization and degeneration (mainly in the skeletal muscles, rarely in the smooth muscles). The incidence of DM is estimated at 1-10 per million in adults and at 1-3.2 per million in children. The autoimmune mechanism of disease induction is not fully recognized. Several lines of evidence showed the link between DM and neoplastic disease. The first report of dermatomyositis associated with stomach cancer, by Stertz, comes from 1916. In the same time, Kankeleit reported DM associated with breast cancer. Presumably, it is the result of immune reaction against antigens common for muscle and neoplastic cells or some paraneoplastic syndrome underlying mechanism. The report presents the case of a 52-year-old woman with DM (diagnosed according to the Bohan and Peter criteria) and with coexistent squamous lung cancer in situ. The left upper lobectomy was performed. No complications in postoperative period were observed. During more than 2 years of follow-up after the surgery, the patient remained in good condition, without DM symptoms, or cancer relapse. Considering that DM may be associated with lung cancer; extensive diagnostic work-up to exclude neoplastic lesions should be performed. Patients aged 40 years or more should be particularly screened.
authors.affiliation: Department of Respiratory Medicine and Tuberculosis, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland. gprzybylski@cm.umk.pl
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Przybylski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Jarzemska
authors.forename: Jarosław
authors.initials: J
authors.lastname: Czerniak
authors.forename: Krystyna
authors.initials: K
authors.lastname: Siemiatkowska
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Gadzińska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Cieśliński
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000000981:diagnostic imaging* / Q000601:surgery; D003882:Dermatomyositis / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging* / Q000601:surgery; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome