title: Hedgehog coordination of postnatal osteoclast and osteoblast activities.
abstract: The Hedgehog (Hh) pathway is important for skeletal patterning and morphogenesis during embryonic development. Papers by Ohba et al. and Mak et al. in this edition of Developmental Cell suggest that Hh signaling may exert delicate control over the activities of osteoclasts and osteoblasts, the cell types primarily responsible for bone resorption and formation.
authors.affiliation: Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. gregory.r.mundy@vanderbilt.edu
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Mundy
authors.forename: Xiangli
authors.initials: X
authors.lastname: Yang
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D006801:Humans; D051379:Mice; D009929:Organ Size; D010006:Osteoblasts / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D010010:Osteoclasts / Q000378:metabolism* / Q000473:pathology; D010012:Osteogenesis; D044162:Parathyroid Hormone-Related Protein / Q000235:genetics; D000072079:Patched Receptors; D053245:RANK Ligand / Q000235:genetics; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D044162:Parathyroid Hormone-Related Protein; D000072079:Patched Receptors; D053245:RANK Ligand; D011956:Receptors, Cell Surface