title: Synthesis and spectroscopic studies of biologically active compounds derived from oxalyldihydrazide and benzil, and their Cr(III), Fe(III) and Mn(III) complexes.
abstract: A new series of complexes have been synthesized by template condensation of oxalyldihydrazide and benzil in methanolic medium in the presence of trivalent chromium, manganese and iron salts forming complexes of the type [M(C(32)H(24)N(8)O(4))X]X(2) where M = Cr(III), Mn(III), Fe(III) and X = Cl(-1), NO(3)(-1), CH(3)COO(-1). The complexes have been characterized with the help of elemental analyses, conductance measurements, magnetic susceptibility measurements, electronic, NMR, infrared and far infrared spectral studies. On the basis of these studies, a five coordinate square pyramidal geometry has been proposed for all these complexes. The biological activities of the metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibiting potential. Some of these complexes have been found to exhibit remarkable antibacterial activities.
authors.affiliation: Department of Chemistry, National Institute of Technology, Kurukshetra 136 119, India. dpsinghchem@yahoo.co.in
authors.forename: D P
authors.initials: DP
authors.lastname: Singh
authors.forename: Ramesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Jitender
authors.initials: J
authors.lastname: Singh
mesh_terms: D000900:Anti-Bacterial Agents / Q000134:cerebrospinal fluid / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002857:Chromium / Q000737:chemistry*; D004553:Electric Conductivity; D004583:Electrons; D007501:Iron / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D008345:Manganese / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010070:Oxalates / Q000737:chemistry*; D010658:Phenylglyoxal / Q000031:analogs & derivatives* / Q000737:chemistry; D013055:Spectrophotometry, Infrared
chemical_list: D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D010070:Oxalates; D002857:Chromium; D008345:Manganese; C014724:oxalic acid hydrazide; D007501:Iron; D010658:Phenylglyoxal; C006697:benzil