title: Asplenia and functional hyposplenism in autoimmune polyglandular syndrome type 1.
abstract: Asplenia was diagnosed in four patients with autoimmune polyendocrine syndrome type-I (APS-I): two children, aged 2-4 years, from the same family and two adults, the father of the two children and his cousin. We have observed a worsening in splenic function in the children during a follow-up of a few years. Patients with APS-I should be evaluated for splenic function, since splenic dysfunction has important therapeutic implications, especially in children.
authors.affiliation: Department of Pediatrics B, Schneider Children's Medical Center of Israel, Petah Tiqwa 49202, Israel.
authors.forename: Uri
authors.initials: U
authors.lastname: Pollak
authors.forename: Zvi
authors.initials: Z
authors.lastname: Bar-Sever
authors.forename: Vered
authors.initials: V
authors.lastname: Hoffer
authors.forename: Nufar
authors.initials: N
authors.lastname: Marcus
authors.forename: Oded
authors.initials: O
authors.lastname: Scheuerman
authors.forename: Ben Zion
authors.initials: BZ
authors.lastname: Garty
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003241:Consanguinity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007492:Iran / Q000208:ethnology; D007557:Israel; D007585:Jews / Q000235:genetics; D008134:Long-Term Care; D008297:Male; D010641:Phenotype; D022242:Pneumococcal Vaccines / Q000008:administration & dosage; D016884:Polyendocrinopathies, Autoimmune / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D013154:Spleen / Q000002:abnormalities*
chemical_list: D000900:Anti-Bacterial Agents; D022242:Pneumococcal Vaccines