[Autoimmune disorders affect the in vitro fertilization outcome in infertile women].
OBJECTIVE
To analyze the effect of autoimmune disorders on the outcome of in vitro fertilization and embryo transfer (IVF-ET) in infertile women.


METHODS
A total of 236 infertile women underwent IVF-ET, including 34 with antiphospholipid antibody (APA) positive, 33 anti-trophoblast antibody (ATA) positive, 35 anti-hCG antibody (hCGAb) positive, 32 anti-endometrium antibody (EmAb) positive, and 102 with antibodies negative that comprised the control group. Those with two or more antibodies positive were excluded in this study. Comparisons were made in the rates of embryo implantation, clinical pregnancy, miscarriage and biochemical pregnancy between the positive groups and the negative controls.


RESULTS
There were no significant differences in the rates of embryo implantation and clinical pregnancy between the positive and negative groups (P > 0.05). The rate of biochemical pregnancy was higher in the APA, ATA and hCGAb positive than in the EmAb positive and the control group (P < 0.05). The miscarriage rate was higher while the ongoing pregnancy rate was lower in the positive groups than in the negative control (P < 0.05).


CONCLUSIONS
Such autoantibodies as APA, ATA, HCG-Ab and EmAb may cause miscarriage in infertile women undergoing IVF and consequently reduce the rate of ongoing pregnancy, which necessitates the determination of these antibodies in these patients.
Zou
Shu-Hua
SH
Reproductive Center, Qingdao Women and Children's Health Medical Center, Qingdao, Shandong 266011, China. zzsshh87516@yahoo.com.cn
Yang
Zong-Zhi
ZZ
Zhang
Peng
P
Song
Dong-Po
DP
Li
Bo
B
Wu
Rui-Ying
RY
Cong
Xue
X
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000150:complications / Q000276:immunology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D011247:Pregnancy; D011256:Pregnancy Outcome
D001323:Autoantibodies