title: Synthesis, Characterization and in Vitro Antifungal Effect of Some Butyltin(IV) N-substituted 2-aminoethanethiolates.
abstract: Six new N-substituted di- and tributyltin 2-aminoethanethiolates (cysteaminates) have been prepared and characterised by (1)H, (13)C and (119)Sn NMR spectroscopy. All these compounds exhibit a good in vitro antifungal effect against selected types of human pathogenic fungi (Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, Trichosporon beigelii, Aspergillus fumigatus, Absidia corymbifera, Trichophyton mentagrophytes) and their activity is comparable with that of some antifungal drugs commonly used in the clinical use like ketoconazole. The structure-activity relationships in these compounds are discussed.
authors.affiliation: Department of General and Inorganic Chemistry Faculty of Chemical Technology University of Pardubice nam. Cs. Legii 565 Pardubice 532 10 Czech Republic.
authors.forename: A
authors.initials: A
authors.lastname: Smicka
authors.forename: V
authors.initials: V
authors.lastname: Buchta
authors.forename: K
authors.initials: K
authors.lastname: Handlir