[Reduction of oxaliplatin-related neurotoxicity by Gosha-jinki-gan].
OBJECTIVE
Oxaliplatin in combination with infusional 5-fluorouracil/Leucovorin (FOLFOX) has emerged as the treatment of choice for advanced-stage colorectal cancer. Sensory neurotoxicity is its dose-limiting toxicity. We decided to use Gosha-jinki-gan for prevention of oxaliplatin-related neurotoxicity following the report of Fushiki et al.


METHODS
The subjects were 14 patients with metastatic colorectal cancer. Oxaliplatin (85 mg/m(2)) was given intravenously as a FOLFOX4 regimen. All 14 patients received Gosha-jinki-gan every day after first oxaliplatin infusion.


RESULTS
7 patients had grade 3 toxicity(neutropenia 6, thrombocytopenia 1). Sensory neuropathy occurred in 10 patients (71.4%). There was no neurotoxicity with functional impairment in this study.


CONCLUSIONS
Gosha-jinki-gan seems to prevent acute oxaliplatin-induced neurotoxicity.
Shindo
Yoshiaki
Y
Dept. of Surgery, Ogachi Chuo Hospital.
Tenma
Kazuo
K
Imano
Hiroshi
H
Hibino
Masanori
M
Yoshino
Kei
K
Nakamura
Masaaki
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000633:toxicity*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000633:toxicity; D015179:Colorectal Neoplasms / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000633:toxicity; D006801:Humans; D002955:Leucovorin / Q000633:toxicity; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000633:toxicity*; D000077150:Oxaliplatin; D010525:Peripheral Nerves / Q000187:drug effects*; D010523:Peripheral Nervous System Diseases / Q000517:prevention & control
D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D009944:Organoplatinum Compounds; C119642:gosha-jinki-gan; D000077150:Oxaliplatin; D002955:Leucovorin; D005472:Fluorouracil