title: Evidence-based renal replacement therapy for acute kidney injury.
abstract: Acute kidney injury (AKI) with the subsequent need for renal replacement therapy (RRT) represents a persistent challenge, arising in 4-5% in critically-ill patients, and remains associated with a high mortality (60%) and morbidity. As AKI is an independent risk factor for poor prognosis, appropriate management of patients with AKI becomes of utmost importance. Complications of AKI can be treated with different forms of RRT, such as continuous veno-venous hemofiltration or intermittent hemodialysis. However, the timing of the initiation, the modality, and the dose of RRT are still controversial and the subject of ongoing clinical trials. This review presents and discusses currently available data regarding the use of RRT in critically-ill patients with AKI.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, University of Münster, Münster, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Zarbock
authors.forename: K
authors.initials: K
authors.lastname: Singbartl
authors.forename: J A
authors.initials: JA
authors.lastname: Kellum
mesh_terms: D058186:Acute Kidney Injury / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D018849:Controlled Clinical Trials as Topic / Q000706:statistics & numerical data; D003422:Critical Care / Q000379:methods / Q000592:standards; D019468:Disease Management; D019317:Evidence-Based Medicine; D006801:Humans; D015201:Meta-Analysis as Topic; D015337:Multicenter Studies as Topic / Q000706:statistics & numerical data; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D017582:Renal Replacement Therapy / Q000379:methods / Q000592:standards