title: Platelet aggregation is not enhanced in patients with prediabetes.
abstract: Prediabetes [impaired glucose tolerance (IGT) and/or impaired fasting glucose (IFG)] is a major risk factor for T2DM as well as for cardiovascular disease and mortality. In the present study, the platelet aggregation and fibrinogen levels were investigated in prediabetic subjects who had no confounding factors such as hypertension, obesity or dyslipidemia. Thirty-nine subjects with prediabetes (24 IFG and 15 IGT) and age, sex and BMI matched 36 healthy controls were enrolled. Platelet aggregation, fibrinogen and hsCRP levels, HOMA-IR and HOMA-beta indexes were determined. Platelet aggregation induced by collagen, epinephrine or ADP was not different (p=0.93, p=0.90 and p=0.29, respectively) between two groups, whereas fibrinogen levels were significantly higher (p=0.006) in the prediabetics when compared to controls. hsCRP levels, HOMA-IR and HOMA-beta indexes in the two groups were not different. The power of the study was calculated according to the results and established as 0.97 for collagen, 0.95 for epinephrine and 0.83 for ADP. Despite the high plasma fibrinogen levels, the platelet aggregation in prediabetics was not different when compared to healthy controls. These data suggest that platelet aggregation may not be involved in the mechanism of prothrombotic state in prediabetic state.
authors.affiliation: Department of Internal Medicine,Etlik, Ankara, Turkey. teomandogru@yahoo.com
authors.forename: Teoman
authors.initials: T
authors.lastname: Dogru
authors.forename: Halil
authors.initials: H
authors.lastname: Genc
authors.forename: Ilker
authors.initials: I
authors.lastname: Tasci
authors.forename: Alper
authors.initials: A
authors.lastname: Sonmez
authors.forename: Gokhan
authors.initials: G
authors.lastname: Erdem
authors.forename: Ali U
authors.initials: AU
authors.lastname: Ural
authors.forename: Ferit
authors.initials: F
authors.lastname: Avcu
authors.forename: Serap
authors.initials: S
authors.lastname: Savasci
authors.forename: Selim
authors.initials: S
authors.lastname: Kilic
authors.forename: Selahattin
authors.initials: S
authors.lastname: Erikci
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000150:complications; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D011236:Prediabetic State / Q000097:blood* / Q000150:complications
chemical_list: D005340:Fibrinogen