Rapid molecular cytogenetic diagnosis of transfusion associated graft-versus-host disease by fluorescent in situ hybridization (FISH).
Transfusion associated graft-versus-host disease (TA-GVHD) is a rare, dreadful complication of transfusion in immunocompromized and immunologically competent individuals. The diagnosis is often delayed, because of lack of awareness and the non-specific clinical features. We describe a rapid molecular cytogenetic analysis of FISH for the diagnosis of two cases of TA-GVHD with sex-mismatched donors. The use of FISH is a rapid and sensitive technique for the early diagnosis of TA-GVHD when the recipient and donor are of different gender.
Akay
Meltem O
MO
Department of Hematology, Eskişehir Osmangazi University Medical School, Eskisehir, Turkey. melhak@hotmail.com
Temiz
Gokhan
G
Teke
Hava U
HU
Gunduz
Eren
E
Acikalin
Mustafa F
MF
Isiksoy
Serap
S
Durak
Beyhan
B
Gulbas
Zafer
Z
D000368:Aged; D017707:Erythrocyte Transfusion; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D012680:Sensitivity and Specificity