title: [Effect of Tongdatang Serial Recipe on antipsychotic drug-induced galactorrhea-amenorrhea syndrome].
abstract: OBJECTIVE
  To observe the clinical effect of self-formulated Tongdatang serial recipe (TDT) in treating antipsychotic drug-induced galactorrhea-amenorrhea syndrome (GAS).
  
  
  METHODS
  One hundred female schizophrenic patients with antipsychotic drug-induced GAS were selected and equally assigned to the treatment group and the control group at random. Both received antipsychotic drug-therapy, but combined with TDT and placebo respectively. The efficacy was evaluated by determining prolactin level before, 4 and 8 weeks after treatment.
  
  
  RESULTS
  The treatment course was completed in 96% of patients. Therapeutic efficacy on the 49 patients of the treatment group was cured in 31 (63.3%), markedly effective in 11 (22.4%), effective in 4 (8.2%) and ineffective in 3 (6.1%), with total effective rate of 93.9%, while in 47 patients of the control group, the corresponding cases (%) was 0, 3 (6.4%) , 7 (14.9%) and 37 (78.7%), respectively, with the total effective rate of 21.3%. Prolactin levels in the two groups were insignificantly different before treatment, it reduced in the treatment group after treatment (P < 0.01), and the decrement in the treatment group was more significant than that in the control group (P < 0.05).
  
  
  CONCLUSIONS
  Satisfactory effect could achieved by using TDT for treatment of antipsychotic drug-induced GAS.
authors.affiliation: Department of the Seventh Zhejiang Provincial Hospital, Hangzhou.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ding
authors.forename: Hui-Zhong
authors.initials: HZ
authors.lastname: Qian
authors.forename: Yi-Qiang
authors.initials: YQ
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000139:chemically induced / Q000188:drug therapy*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005687:Galactorrhea / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D008517:Phytotherapy; D012559:Schizophrenia / Q000188:drug therapy; D013577:Syndrome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D004365:Drugs, Chinese Herbal; C534023:tongdatang