title: Bradykinin receptors in intestinal smooth muscles and their post-receptor events related to calcium.
abstract: The effects of trifluoperazine and verapamil on bradykinin- and des-Arg(9)-bradykinin induced responses of isolated rat duodenum and guinea-pig ileum were investigated to elucidate post-bradykinin receptor events. Verapamil and trifluoperazine inhibited bradykinin induced relaxations and contractions and des-Arg(9)- bradykinin induced contractions in rat duodenum. Bradykinin induced contractions of ileum were also inhibited by trifluoperazine and. verapamil. Since non-competitive affinity constants of trifluoperazine and verapamil for the relaxant responses to bradykinin in duodenum and for the contractile responses to bradykinin in ileum are different, post-bradykinin receptor events related to calcium may be different in ileum and duodenum. In addition, affinity constants of bradykinin in guinea-pig ileum and rat duodenum are also disparate suggesting the presence of different types of bradykinin B(2) receptors in these two organs.
authors.affiliation: Department of Pharmacology Faculty of Pharmacy Anadolu University Eskieşhir 26470 Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Oztürk
authors.forename: V M
authors.initials: VM
authors.lastname: Altan
authors.forename: N
authors.initials: N
authors.lastname: Yıdızoğlu-Arı
authors.forename: O
authors.initials: O
authors.lastname: Altınkurt