Pathology of uterine malignancies.
This overview covers epithelial, stromal and mesenchymal malignancies of the body of the uterus, excluding the cervix. The distinction of type I and type II endometrial adenocarcinoma with the morphological variants of this tumour is discussed and some molecular aspects are explored. The concept of carcinosarcoma representing a metaplastic adenocarcinoma of the endometrium that behaves more like a carcinoma than a sarcoma is explained. Some types of mixed epithelial and stromal neoplasm are described and contrasted with carcinosarcoma. The concept of stromal sarcoma and high-grade uterine sarcoma is described and an outline of malignant smooth muscle tumours of the uterus includes a description of smooth muscle tumours of uncertain malignant potential and worrying benign smooth muscle lesions.
Brown
L
L
Department of Histopathology, Leicester Royal Infirmary, Infirmary Square, Leicester, UK. laurence.brown@uhl-tr.nhs.uk
D000230:Adenocarcinoma / Q000473:pathology; D036821:Endometrial Stromal Tumors / Q000473:pathology; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology; D008648:Mesoderm / Q000473:pathology; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology; D012509:Sarcoma / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000473:pathology*