Chondrocyte apoptosis: implications for osteochondral allograft transplantation.
Osteochondral allograft transplantation is a useful technique to manage larger articular cartilage injuries. One factor that may compromise the effectiveness of this procedure is chondrocyte cell death that occurs during the storage, preparation, and implantation of the osteochondral grafts. Loss of viable chondrocytes may negatively affect osteochondral edge integration and long-term function. A better understanding of the mechanisms responsible for chondrocyte loss could lead to interventions designed to decrease cell death and improve results. Recent studies indicate that apoptosis, or programmed cell death, is responsible for much of the chondrocyte death associated with osteochondral allograft transplantation. Theoretically, some of these cells can be rescued by blocking important apoptotic mediators. We review the role of apoptosis in cartilage degeneration, focusing on apoptosis associated with osteochondral transplantation. We also review the pathways thought to be responsible for regulating chondrocyte apoptosis, as well as experiments testing inhibitors of the apoptotic pathway. These data suggest that key contributors to the apoptotic process can be manipulated to enhance chondrocyte survival. This knowledge may lead to better surgical outcomes for osteochondral transplantation.
Kim
Hubert T
HT
Orthopedic Surgery Section, San Francisco VA Medical Center, 4150 Clement Street (112), San Francisco, CA 94121, USA. kimh@orthosurg.ucsf.edu
Teng
Margie S
MS
Dang
Alexis C
AC
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D016025:Bone Transplantation / Q000502:physiology*; D002358:Cartilage, Articular / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology; D019902:Chondrocytes / Q000502:physiology* / Q000637:transplantation*; D006801:Humans; D014021:Tissue Preservation; D014184:Transplantation, Homologous