Large cell transformation mimicking regional lymphomatoid papulosis in a patient with mycosis fungoides.
A 57-year-old Japanese man with tumor-stage mycosis fungoides suddenly presented multiple small papules on the right chest. Histopathology of a biopsy specimen from the papules revealed medium-to-large pleomorphic lymphoid cells throughout the entire dermis but not in the epidermis, and the large cells expressed CD30 antigen. These newly-developed papules underwent spontaneous remission in the following 3 months. We reviewed the reported cases of mycosis fungoides, which showed CD30-positive large cell transformation and those of CD30-positive lymphoproliferative disorders associated with mycosis fungoides.
Nakahigashi
Kyoko
K
Department of Dermatology, Kyoto University Hospital, Kyoto, Japan. itononaka@ybb.ne.jp
Ishida
Yuya
Y
Matsumura
Yumi
Y
Kore-Eda
Satoshi
S
Ohmori
Katsuyuki
K
Fujimoto
Masakazu
M
Yamashita
Kyoko
K
Kotani
Hirokazu
H
Sakurai
Takaaki
T
Miyachi
Yoshiki
Y
D001706:Biopsy; D002471:Cell Transformation, Neoplastic; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis; D017731:Lymphomatoid Papulosis / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy / Q000473:pathology*; D011701:PUVA Therapy; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*
D017730:Ki-1 Antigen