Cornification defect in the golden retriever: clinical, histopathological, ultrastructural and genetic characterisation.
Veterinarians have recognised a nonpruritic skin disease in the Golden retriever breed characterised by excessive scaling of large, variably pigmented flakes of skin in otherwise healthy dogs. This prospective case series describes clinical, histopathological, ultrastructural and genetic features of this cornification defect in 17 affected dogs. The condition affects young dogs of either sex and is characterised by symmetrical, predominantly ventro-lateral scaling and hyperpigmentation of the trunk. Histopathological and ultrastructural changes of the stratum corneum are suggestive of delayed degradation of corneodesmosomes. A genetic aetiology is proposed and a single-trait autosomal recessive mode of inheritance discussed.
Cadiergues
Marie-Christine
MC
Department of Veterinary Clinical Sciences, Royal Veterinary College, North Mymms, Hatfield, Herts, UK.
Patel
Anita
A
Shearer
David H
DH
Fermor
Ruth
R
Miah
Suhel
S
Hendricks
Anke
A
D000818:Animals; D004283:Dog Diseases / Q000235:genetics* / Q000473:pathology*; D004285:Dogs; D005260:Female; D020022:Genetic Predisposition to Disease; D017495:Hyperpigmentation / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000662:veterinary; D010375:Pedigree; D011446:Prospective Studies; D012867:Skin / Q000473:pathology* / Q000648:ultrastructure; D012871:Skin Diseases / Q000235:genetics / Q000473:pathology / Q000662:veterinary*