title: Canine intraspinal meningiomas: imaging features, histopathologic classification, and long-term outcome in 34 dogs.
abstract: BACKGROUND
  Meningioma is the most common primary intraspinal nervous system tumor in dogs. Clinical findings, clinicopathologic data, and treatment of these tumors have been reported sporadically, but little information is available regarding cerebrospinal fluid (CSF) analysis, histologic tumor grade, or efficacy of radiation therapy as an adjunct to cytoreductive surgery.
  
  
  METHODS
  Dogs with histologically confirmed intraspinal meningiomas (n = 34).
  
  
  METHODS
  A retrospective study of dogs with intraspinal meningiomas between 1984 and 2006 was carried out. Signalment, historical information, physical examination, clinicopathologic data, radiation therapy protocols, surgery reports, and all available images were reviewed. All tumors were histologically classified and graded as defined by the international World Health Organization classification scheme for central nervous system tumors.
  
  
  RESULTS
  Intraspinal mengiomas in dogs are most common in the cervical spinal cord but can be found throughout the neuraxis. Location is correlated with histologic grade, with grade I tumors more likely to be in the cervical region than grade II tumors. Myelography generally shows an intradural extramedullary compressive lesion. On magnetic resonance imaging, the masses are strongly and uniformly contrast enhancing and a dural tail often is present. CSF analysis usually shows increased protein concentration with mild to moderate mixed pleocytosis. Surgical resection is an effective means of improving neurologic status, and adjunctive radiation therapy may lead to an improved outcome.
  
  
  CONCLUSIONS
  Biopsy is necessary for definitive diagnosis, but imaging and CSF analysis can suggest a diagnosis of meningioma. Treatment of meningiomas with surgery and radiation therapy can result in a fair to excellent prognosis.
authors.affiliation: Department of Surgical and Radiological Sciences, University of California, Davis, CA 95616-8747, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Petersen
authors.forename: B K
authors.initials: BK
authors.lastname: Sturges
authors.forename: P J
authors.initials: PJ
authors.lastname: Dickinson
authors.forename: R E
authors.initials: RE
authors.lastname: Pollard
authors.forename: P H
authors.initials: PH
authors.lastname: Kass
authors.forename: M
authors.initials: M
authors.lastname: Kent
authors.forename: K M
authors.initials: KM
authors.lastname: Vernau
authors.forename: R A
authors.initials: RA
authors.lastname: Lecouteur
authors.forename: R J
authors.initials: RJ
authors.lastname: Higgins
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000145:classification / Q000473:pathology*; D004285:Dogs; D005260:Female; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D008579:Meningioma / Q000145:classification / Q000473:pathology / Q000662:veterinary*; D011859:Radiography / Q000662:veterinary; D012189:Retrospective Studies