[Intraocular infection with herpesviruses and antiviral immunity in patients with age-related macular degeneration].
Polymerase chain reaction revealed Herpesviridae (Herpes simplex, Cytomegalovirus) in the lens substance in 46 patients operated on for age-related cataract. Thirty-two patients of them had age-related macular degeneration. Herpes simplex was found in 6 (18.8%) of the patients with age-related macular degeneration. At the same time there were signs of lacrimal fluid antiviral immunity imbalance with decreased IFN-gamma and TNF-alpha and increased IFN-alpha. The authors consider it advisable to perform antivirus treatment in patients with the above abnormality, preventing the active forms of herpetic infection.
Mukhamed'ianova
A Sh
ASh
Aznabaev
R A
RA
Aznabaeva
L F
LF
D000368:Aged; D000914:Antibodies, Viral / Q000276:immunology*; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D015828:Eye Infections, Viral / Q000150:complications* / Q000276:immunology / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D006561:Herpes Simplex / Q000150:complications* / Q000276:immunology / Q000821:virology; D006801:Humans; D007908:Lens, Crystalline / Q000821:virology; D008268:Macular Degeneration / Q000150:complications* / Q000276:immunology / Q000821:virology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012720:Severity of Illness Index; D018139:Simplexvirus / Q000235:genetics / Q000276:immunology*; D013666:Tears / Q000821:virology
D000914:Antibodies, Viral; D004279:DNA, Viral