Aqueous extract of Anemarrhena rhizome increases cell proliferation and neuropeptide Y expression in the hippocampal dentate gyrus on streptozotocin-induced diabetic rats.
In this study, the effects of the aqueous extract of Anemarrhena rhizome on cell proliferation and neuropeptide Y expression in the dentate gyrus of streptozotocin-induced diabetic rats were investigated via immunohistochemistry for 5-bromo-2'-deoxyuridine (BrdU) and neuropeptide Y. The results showed that the treatment with 50 to 200 microg/kg/day for 7 days of the aqueous extract of Anemarrhena rhizome increased new cell formation and neuropeptide Y expression in the dentate gyrus of diabetic rats reduced by the treatment with streptozotocin in rat.
Shin
Mal-Soon
MS
Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea. malsoon@khu.ac.kr
Kim
Su-Kyung
SK
Kim
Youn-Sub
YS
Kim
Sung-Eun
SE
Ko
Il-Gyu
IG
Kim
Young-Sick
YS
Kim
Chang-Ju
CJ
Kim
You-Mi
YM
Kim
Bo-Kyun
BK
Kim
Tae-Soo
TS
D031403:Anemarrhena / Q000737:chemistry*; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D018891:Dentate Gyrus / Q000166:cytology / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental; D005786:Gene Expression Regulation / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D009478:Neuropeptide Y / Q000235:genetics / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome / Q000737:chemistry*; D013311:Streptozocin
D007004:Hypoglycemic Agents; D009478:Neuropeptide Y; D010936:Plant Extracts; D013311:Streptozocin