Prevalence and patterns of antimicrobial resistance of fecal Escherichia coil among pigs on 47 farrow-to-finish farms with different in-feed medication policies in Ontario and British Columbia.
The main objectives of this study were to determine the prevalence and patterns of antimicrobial resistance in pigs on farms that medicated swine ration and those that did not. A total of 940 isolates of Escherichia coli from 188 pooled fecal samples obtained from weaner and finisher pigs on 47 farrow-to-finish swine farms (34 farms used in-feed medication and 13 did not) were tested for susceptibility to 21 antimicrobials using a breakpoint concentration method. The prevalence of resistance varied widely (0.0% to 81.3%) among the antimicrobials tested. Ninety percent of all the isolates tested were resistant to one or more antimicrobials. The most common multi-drug resistance patterns were to 2 to 6 antimicrobials. Resistance was significantly more frequent (P < 0.01) on farms that used in-feed medication compared to those that did not, and significantly more frequent (P < 0.01) in weaner pigs compared to finisher pigs. These findings indicate that resistance to a broad range of antimicrobials was prevalent among fecal E. coli isolates of pigs on study farms, and that this constitutes a potential reservoir for resistance genes that could spread to pathogens. The findings also provide further evidence that use of medication in swine rations provides selective pressure for antimicrobial resistance in E. coli in pigs.
Akwar
Holy T
HT
Department of Population Medicine, University of Guelph, Guelph, Ontario N1G 2W1. holy.akwar@gnb.ca
Poppe
Cornelis
C
Wilson
Jeff
J
Reid-Smith
Richard J
RJ
Dyck
Monica
M
Waddington
Josh
J
Shang
Dayue
D
McEwen
Scott A
SA
D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001955:British Columbia / Q000453:epidemiology; D015169:Colony Count, Microbial / Q000662:veterinary; D004197:Disease Reservoirs / Q000382:microbiology / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D004926:Escherichia coli / Q000187:drug effects*; D005243:Feces / Q000382:microbiology*; D005260:Female; D008297:Male; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D009864:Ontario / Q000453:epidemiology; D015995:Prevalence; D013552:Swine / Q000254:growth & development / Q000382:microbiology
D000900:Anti-Bacterial Agents