An overview of the fission yeast septation initiation network (SIN).
The fission yeast septation initiation network, or SIN, is a signal transduction network that is required for septum formation in Schizosaccharomyces pombe. Its activity is tightly regulated through the cell cycle, to ensure proper co-ordination of mitosis and cytokinesis. SIN signalling requires three protein kinases for its function and is mediated by a ras-superfamily GTPase. We discuss the elements of the SIN and how they are regulated.
Krapp
Andrea
A
Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1066 Epalinges s/Lausanne, Switzerland. andrea.krapp@epfl.ch
Simanis
Viesturs
V
D002455:Cell Division; D008540:Meiosis; D021381:Protein Transport; D012568:Schizosaccharomyces / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism*
D029702:Schizosaccharomyces pombe Proteins