title: Solvent-controlled regioselective protection of 5'-O-protected thymidine.
abstract: This paper describes an efficient procedure for selective 3'-O- or 3-N-protection of 5'-O-tert-butyldimethylsilylthymidine, depending on the use of aprotic polar solvents with low or high dielectric constant, respectively. These syntheses were activated by either ultrasound or microwaves. Several alkyl bromides offer a convenient route to prepare 3'-O- or 3-N-protected and functionalized thymidine derivatives.
authors.affiliation: Laboratoire de Chimie des Substances Naturelles EA1069, Faculté des Sciences et Techniques, 123 Avenue Albert Thomas, F-87060 Limoges, France.
authors.forename: K
authors.initials: K
authors.lastname: Teste
authors.forename: L
authors.initials: L
authors.lastname: Colombeau
authors.forename: A
authors.initials: A
authors.lastname: Hadj-Bouazza
authors.forename: R
authors.initials: R
authors.lastname: Lucas
authors.forename: R
authors.initials: R
authors.lastname: Zerrouki
authors.forename: P
authors.initials: P
authors.lastname: Krausz
authors.forename: Y
authors.initials: Y
authors.lastname: Champavier
mesh_terms: D001965:Bromides / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D012997:Solvents / Q000737:chemistry*; D013237:Stereoisomerism; D013936:Thymidine / Q000737:chemistry*
chemical_list: D001965:Bromides; D012997:Solvents; D013936:Thymidine