title: [Complications and monitoring of the latency period after a preterm premature rupture of the fetal membranes: literature review].
abstract: Preterm premature rupture of the membranes (PPROM) begins a high-risk period for both mother and fetus. This literature review updates the knowledge on latency-period complications and proposed monitoring strategies. Four latency-period complications are described: spontaneous onset of labor, infection (chorioamnionitis), abruptio placentae, and fetal, distress which can be linked to umbilical cord prolapse. Admittedly, the infection/inflammation process plays a key role during the latency period. Conservative management of PPROM is recommended and is associated with significant pregnancy prolongation. This strategy allows a gain in fetal maturity, but increases the risk of complications. The prediction of infection seems to be essential; classical markers, such as blood count and reactive C protein are not very effective. New markers have been tested, with IL-6 appearing to be one of the best infection markers. Fetal pulmonary maturity can be evaluated with a rapid screening test and can yield arguments for the management strategy.
authors.affiliation: Département de gynécologie-obstétrique, faculté de médecine, université de Sherbrooke, Sherbrooke, Qc J1H 5N4, Canada. jean-charles.pasquier@usherbrooke.ca
authors.forename: J-C
authors.initials: JC
authors.lastname: Pasquier
authors.forename: M
authors.initials: M
authors.lastname: Doret
mesh_terms: D000037:Abruptio Placentae / Q000209:etiology*; D000653:Amniotic Fluid / Q000737:chemistry; D015415:Biomarkers / Q000097:blood; D002821:Chorioamnionitis / Q000209:etiology*; D005260:Female; D005316:Fetal Distress / Q000209:etiology*; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis* / Q000276:immunology; D005323:Fetal Monitoring; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007752:Obstetric Labor, Premature / Q000209:etiology*; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D015850:Interleukin-6