title: Bioorganometallic fulvene-derived titanocene anti-cancer drugs.
abstract: 6-Substituted fulvenes are interesting and easily accessible starting materials for the synthesis of novel substituted titanocenes via reductive dimerisation, carbolithiation or hydridolithiation reactions, which are followed by a transmetallation reaction with titanium tetrachloride in the latter two cases. Depending on the substitution pattern, these titanocenes prove to be bioorganometallic anti-cancer drugs, which have significant potential against advanced or metastatic renal-cell cancer. Patients bearing these stages of kidney cancer have a poor prognosis so far and therefore real progress in the area of metal-based anti-cancer drugs may come from this simple and effective synthetic approach. This tutorial review provides an insight into the synthesis of fulvene-derived titanocenes and their activity in preclinical experiments.
authors.affiliation: School of Pharmacy, The University of Reading, PO Box 224, Whiteknights, Reading, Berkshire, UK. k.strohfeldt@reading.ac.uk
authors.forename: Katja
authors.initials: K
authors.lastname: Strohfeldt
authors.forename: Matthias
authors.initials: M
authors.lastname: Tacke
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D003517:Cyclopentanes / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D007680:Kidney Neoplasms / Q000188:drug therapy*; D018374:LLC-PK1 Cells; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013552:Swine
chemical_list: D000970:Antineoplastic Agents; D003517:Cyclopentanes; D009942:Organometallic Compounds; C406884:titanocene; C017332:fulvene