title: [Influence of integrin-binding motif (RGD) on attachment and internalization of avian adenovirus CELO in mammalian cells].
abstract: Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a HI-loop of long fiber was designed. Experiments in vitro revealed that introduction of RGD-motif into fiber of CELO increased the ability of the virus to be attached to a surface of CAR-negative cells, and raised efficiency of the process of internalization of the virus both in CAR-positive, and in CAR-negative cells.
authors.forename: O V
authors.initials: OV
authors.lastname: Zubkova
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Logunov
authors.forename: A P
authors.initials: AP
authors.lastname: Karpov
authors.forename: M M
authors.initials: MM
authors.lastname: Shmarov
authors.forename: R V
authors.initials: RV
authors.lastname: Belousova
authors.forename: B S
authors.initials: BS
authors.lastname: Naroditskiĭ
mesh_terms: D000257:Adenoviridae Infections / Q000821:virology*; D000818:Animals; D000956:Antigens, Viral / Q000235:genetics; D000259:Aviadenovirus / Q000502:physiology*; D036022:Capsid Proteins / Q000235:genetics; D045744:Cell Line, Tumor; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D005822:Genetic Vectors / Q000502:physiology*; D006801:Humans; D039564:Integrin alphaV / Q000378:metabolism; D009842:Oligopeptides / Q000502:physiology*; D016865:Reassortant Viruses / Q000502:physiology*; D011991:Receptors, Virus / Q000172:deficiency; D011995:Recombination, Genetic; D014161:Transduction, Genetic; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral; C568771:CLMP protein, human; D036022:Capsid Proteins; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D039564:Integrin alphaV; D009842:Oligopeptides; D011991:Receptors, Virus; C018315:hexon capsid protein, Adenovirus; C047981:arginyl-glycyl-aspartic acid