Cancer and fertility preservation: fertility preservation in breast cancer patients.
Aggressive chemotherapy has improved the life expectancy for reproductive-age women with breast cancer, but it often causes infertility or premature ovarian failure due to destruction of the ovarian reserve. Many questions concerning fertility preservation in breast cancer patients remain unanswered--for example, whether fertility preservation methods interfere with chemotherapy, and whether subsequent pregnancy has negative effects on the prognosis. Fertility preservation is a critical factor in decision-making for younger breast cancer patients, however, and clinicians should address this. The present article reviews the incidence of chemotherapy-induced amenorrhea, and discusses fertility-preservation options and the prognosis for patients who become pregnant after breast cancer.
Maltaris
Theodoros
T
Department of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz University Hospital, Langenbeckstr, 1, 55124 Mainz, Germany. maltaris@uni-mainz.de
Weigel
Michael
M
Mueller
Andreas
A
Schmidt
Marcus
M
Seufert
Rudolf
R
Fischl
Franz
F
Koelbl
Heinz
H
Dittrich
Ralf
R
D000568:Amenorrhea / Q000139:chemically induced / Q000517:prevention & control; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D015925:Cryopreservation; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000139:chemically induced* / Q000517:prevention & control*; D008594:Menopause, Premature; D009865:Oocytes; D011237:Predictive Value of Tests; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011379:Prognosis; D027724:Reproductive Techniques, Assisted; D017741:Survivors