title: New sulfoalkylresorcinol from marine-derived fungus, Zygosporium sp. KNC52.
abstract: A new sulfoalkylresorcinol (1) was isolated from the marine-derived fungus, Zygosporium sp. KNC52. The structure of 1 was elucidated by spectroscopic methods including MS and NMR, and the absolute stereochemistry was determined by the modified Mosher's method. Compound 1 inhibited FtsZ polymerization in vitro and exhibited weak antimicrobial activity against multi-drug-resistant bacteria.
authors.affiliation: Marine Biotechnology Institute Co., Ltd, Kamaishi, Iwate, Japan. kaneo.kanoh@mbio.jp
authors.forename: Kaneo
authors.initials: K
authors.lastname: Kanoh
authors.forename: Kyoko
authors.initials: K
authors.lastname: Adachi
authors.forename: Satoru
authors.initials: S
authors.lastname: Matsuda
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Shizuri
authors.forename: Ko
authors.initials: K
authors.lastname: Yasumoto
authors.forename: Takenori
authors.initials: T
authors.lastname: Kusumi
authors.forename: Kayo
authors.initials: K
authors.lastname: Okumura
authors.forename: Teruo
authors.initials: T
authors.lastname: Kirikae
mesh_terms: D001419:Bacteria / Q000187:drug effects; D001426:Bacterial Proteins / Q000737:chemistry; D003598:Cytoskeletal Proteins / Q000737:chemistry; D005658:Fungi / Q000737:chemistry / Q000378:metabolism*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D012118:Resorcinols / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; C071525:FtsZ protein, Bacteria; D007202:Indicators and Reagents; D012118:Resorcinols