Encephalic large arteries narrowness and peripheral neuropathy in a patient with adult-onset Still's disease.
Adult-onset Still's disease (AOSD) is a rare, systemic inflammatory disorder, characterized by spiking high fever, fever-associated evanescent rash, arthritis, myalgia, serositis and hepatosplenomegaly. White blood cell count, neutrophilic cell count, and serum ferritin level are markedly elevated in the active stage of the disease. Neurological complications of AOSD commonly were cranial nerve palsies, seizures, aseptic meningoencephalitis, peripheral neuropathy and Miller-Fisher syndrome. We report a previously healthy 60-year-old Chinese man who fulfilled the criteria for AOSD and had a combination of focal and peripheral neurological symptoms. Magnetic resonance angiography (MRA) and transcranial Doppler ultrasonography (TCD) showed narrowness of cerebral blood vessel. Peripheral neuropathy was confirmed by electromyography and sural nerve biopsy. His generalized neuropathy and other symptoms were rapidly improved by receiving glucocorticoid therapy. We do a literature review about neurological manifestations observed in AOSD patients.
Zhao
Hong
H
Department of Infectious Diseases, Peking University First Hospital, 8, Xishiku Street, West District, 100034 Beijing, People's Republic of China. minmin2001@gmail.com
Yuan
Yun
Y
Li
Yue
Y
Si
Chong-Wen
CW
Tian
Geng-Shan
GS
Wang
Gui-Qiang
GQ
Yang
Xue-Dong
XD
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002340:Carotid Artery Diseases / Q000209:etiology* / Q000473:pathology; D002343:Carotid Artery, Internal / Q000473:pathology; D002539:Cerebral Arterial Diseases / Q000209:etiology* / Q000473:pathology; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000209:etiology*; D016706:Still's Disease, Adult-Onset / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone