[Expression and implication of CD44 and nm23-H1 proteins in laryngeal carcinoma].
OBJECTIVE
To study the expression of CD44 and nm23-H1 gene proteins and their clinical significance in laryngeal carcinoma.


METHODS
The expression of CD44 and nm23-H1 proteins were detected by immunohistochemistry method in 40 cases with laryngeal carcinoma, 20 adjacent carcinoma tissues and 12 cases normal laryngeal mucosa tissues.


RESULTS
The expression of CD44 and nm23-H1 proteins in laryngeal carcinoma were much higher than that in normal laryngeal mucosa. The expression of CD44 protein in laryngeal carcinoma with metastatic lymph node was higher than that in laryngeal carcinoma without metastatic lymph node, but nm23-H1 protein lower. The expression of CD44 protein was positively correlated with the metastasis, clinical staging and pathological classification but not correlated with T classification of laryngeal carcinoma. The expression of nm23-H1 protein was negative correlation with the metastasis and clinical staging of laryngeal carcinoma.


CONCLUSIONS
CD44 and nm23-H1 gene proteins play an important coordinated regulation role in the carcinogenesis, development and metastasis of laryngeal carcinoma and will probably become the key biological marks in the judging and evaluating prognosis of laryngeal carcinoma.
Yang
Xiuying
X
Department of Otorhinolaryngology, Affiliated Hospital, Ningxia Medical Collegy, Yin-chuan, 750004, China.
Liu
Mingfang
M
Han
Enshan
E
Guo
Hongqing
H
Yang
Zhichao
Z
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D054778:NM23 Nucleoside Diphosphate Kinases / Q000378:metabolism*; D009367:Neoplasm Staging
C497483:CD44 protein, human; D018960:Hyaluronan Receptors; D054778:NM23 Nucleoside Diphosphate Kinases; C517938:NME1 protein, human