[Effects of vasotocin analogs on excretion of Na+, K+, and Mg2+ ions via rat kidney].
Experiments on rats showed that the intramuscular injections of arginine-vasotocin (AVT), 1-deamino-arginine-vasotocin (1dAVT) or 1-deamino-1-monocarba-arginine-vasotocin (1dlmcAVT) at a dose of 5 x 10(-11) mole per 100 g body weight increase renal excretion of Na+, K+, and Mg2+. Antagonist of V1 receptors (OPC-21268) decreases the effect of 1dAVT nonapeptides on renal excretion of the studied ions. A model of VIb-receptor is constructed and a correlation is shown between the energy of interaction of the V1b-receptor and the natriuretic effect of the studied vasotocin analogs.
Natochin
Iu V
IuV
Kanashkina
T A
TA
Shakhmatova
E I
EI
Bespalova
Zh D
ZhD
Mordvintsev
D Iu
DIu
Poliak
Ia L
IaL
D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D002412:Cations / Q000378:metabolism; D004231:Diuresis / Q000187:drug effects / Q000502:physiology; D005260:Female; D017136:Ion Transport; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008274:Magnesium / Q000378:metabolism*; D008958:Models, Molecular; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D017483:Receptors, Vasopressin / Q000502:physiology*; D012964:Sodium / Q000378:metabolism*; D014668:Vasotocin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D065092:Antidiuretic Hormone Receptor Antagonists; D002412:Cations; D017483:Receptors, Vasopressin; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D014668:Vasotocin