2D NMR Methods for Structural Delineation of Copper(II) Complexes of Penicillin and Pilocarpine.
A method was developed for delineating the structure of paramagnetic metal complexes. The selective disappearance of cross-peaks in proton-carbon shift correlated 2D NMR maps was shown to uniquely depend upon the scalar and/or dipolar interaction between ligand nuclei and the unpaired electron(s), thus providing a means of identifying binding sites. Copper(II) was shown to form metal complexes with both Penicillin (PNC) and Pilocarpine (PLC) and the structure of the two 1:2 complexes in water solution at physiological pH were determined.
Gaggelli
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Department of Chemistry University of Siena Pian dei Mantellini 44 Siena I-53100 Italy.
Gaggelli
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Valensin
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