title: Biomonitoring of polybrominated diphenyl ether (PBDE) pollution: a field study.
abstract: Polybrominated diphenyl ethers (PBDEs) and cytochrome P450 enzyme activities were investigated in European eels (Anguilla anguilla) collected from seven sites in a coastal lagoon in the north-western Mediterranean Sea, Orbetello lagoon (Italy). Twelve PBDE congeners were measured in muscle and two CYP1A enzyme activities, 7-ethoxyresorufin-O-deethylase (EROD) and benzo(a)pyrene monooxygenase (BP(a)PMO), were investigated in liver microsomal fraction in order to obtain insights into the health of the lagoon environment. PBDE muscle levels were low and the most abundant congeners were 2,2',4,4'-tetrabromodiphenylether (BDE-47), 2,2',4,4',5,5'-hexaBDE (BDE-153) and 2,2',4,5'-tetraBDE (BDE-49). EROD and B(a)PMO activities were also low and no differences were observed between eels from different sites. Multivariate analysis (PCA) did not indicate correlations between PBDEs and either P450 activities.
authors.affiliation: Department of Environmental Sciences G. Sarfatti, University of Siena, Via Mattioli 4, 53100 Siena, Italy. mariottinim@unisi.it
authors.forename: Michela
authors.initials: M
authors.lastname: Mariottini
authors.forename: Ilaria
authors.initials: I
authors.lastname: Corsi
authors.forename: Camilla
authors.initials: C
authors.lastname: Della Torre
authors.forename: Tancredi
authors.initials: T
authors.lastname: Caruso
authors.forename: Aldo
authors.initials: A
authors.lastname: Bianchini
authors.forename: Ilaria
authors.initials: I
authors.lastname: Nesi
authors.forename: Silvia
authors.initials: S
authors.lastname: Focardi
mesh_terms: D000811:Anguilla / Q000378:metabolism*; D000818:Animals; D001579:Benzopyrene Hydroxylase / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D004784:Environmental Monitoring / Q000379:methods*; D055768:Halogenated Diphenyl Ethers; D007558:Italy; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009132:Muscles / Q000378:metabolism*; D010647:Phenyl Ethers / Q000378:metabolism* / Q000633:toxicity; D010865:Pilot Projects; D011075:Polybrominated Biphenyls / Q000378:metabolism* / Q000633:toxicity; D025341:Principal Component Analysis; D015203:Reproducibility of Results; D014874:Water Pollutants, Chemical / Q000378:metabolism* / Q000633:toxicity
chemical_list: D015415:Biomarkers; D055768:Halogenated Diphenyl Ethers; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; D014874:Water Pollutants, Chemical; C517828:hexabrominated diphenyl ether 153; C511295:2,2',4,4'-tetrabromodiphenyl ether; D001579:Benzopyrene Hydroxylase; D019363:Cytochrome P-450 CYP1A1