Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) detection in cancer patients: a prognostic marker for lung metastases from solid malignancies.
The aim of the study was to evaluate the serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) levels in breast, lung and colorectal cancer patients in correlation with clinical variables.


METHODS
A total of 59 patients with a median age of 64 years and histologically confirmed breast 14, colorectal 15 or lung cancer 30 were evaluated. Five patients with breast cancer, 7 patients with colorectal cancer and 8 patients with lung cancer had lung metastases. Blood was collected upon enrolment, centrifuged and the serum kept at -80 degrees C until assayed for sTREM-1. The estimation of sTREM-1 was performed by a crude enzyme immunoabsorbent assay.


RESULTS
High levels of sTREM-1 were observed in 50% of breast cancer, 33.3% of Small Cell Lung carcinoma (SCLC), 26.7% of colorectal cancer and 13.3% of Non Small Cell Lung Carcinoma (NSCLC) patients. sTREM-1 expression showed a correlation to the site of metastases. Higher concentrations were observed in the absence of lung metastases (p=0.019).


CONCLUSIONS
The novel mediator sTREM-1 may be a prognostic marker for the detection of lung metastases in metastatic and locally advanced solid tumors.
Karapanagiotou
Eleni M
EM
Athens University School of Medicine, Oncology Unit, Third Department of Medicine, Sotiria General Hospital, Athens, Greece. lkarapanagiotou@hotmail.com
Pelekanou
Emilia
E
Charpidou
Adrianni
A
Tsaganos
Thomas
T
Anagnostou
Valsamo
V
Plachouras
Diamantis
D
Giamarellos-Bourboulis
Evangelos J
EJ
Syrigos
Kostas N
KN
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000473:pathology / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000097:blood / Q000473:pathology / Q000556:secondary; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology / Q000556:secondary*; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D009367:Neoplasm Staging; D011971:Receptors, Immunologic / Q000097:blood*; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
D014408:Biomarkers, Tumor; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1