Effects of bemiparin, dalteparin, and unfractionated heparin on platelet interaction with human subendothelium under flow conditions.
We compared the effects of the low-molecular-weight heparin (LMWH), bemiparin, and dalteparin with unfractionated heparin (UFH) on the platelet subendothelium interaction under flow conditions. All three compounds decreased the percentage of subendothelial matrix covered by platelets, although the effect of LMWH was greater than that of UFH. Subendothelial matrix covered with platelet structures greater than 100 square microns was significantly reduced by all three compounds; the effect of bemiparin tended to be greater than that of the other two heparins.
González-Correa
Jose Antonio
JA
Department of Pharmacology and Therapeutics, School of Medicine, University of Málaga, Spain.
Arrebola
María Monsalud
MM
Mérida
Francisco
F
Navas
María Dolores
MD
López-Villodres
Juan Antonio
JA
Samanes
Felisa
F
Cruz
José Pedro De La
JP
D000328:Adult; D000925:Anticoagulants / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects*; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D017985:Dalteparin / Q000494:pharmacology*; D042783:Endothelial Cells / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology*; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011673:Pulsatile Flow; D013314:Stress, Mechanical
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D006493:Heparin; C411345:bemiparin; D017985:Dalteparin