Synthesis and structure-activity relationship of aminopyrimidine IKK2 inhibitors.
The synthesis and structure-activity relationship of a novel series of aminopyrimidines are exemplified. Results of key compounds from within this series in the E-selectin reporter cell assay are also reported.
Bingham
Alistair H
AH
UCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK.
Davenport
Richard J
RJ
Fosbeary
Richard
R
Gowers
Lewis
L
Knight
Roland L
RL
Lowe
Christopher
C
Owen
David A
DA
Parry
David M
DM
Pitt
Will R
WR
D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D019040:E-Selectin / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors*; D008958:Models, Molecular; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D019040:E-Selectin; D004791:Enzyme Inhibitors; D011743:Pyrimidines; D051550:I-kappa B Kinase