Cardiovagal modulation upon postural change is altered in Huntington's disease.
BACKGROUND
Cardiac autonomic nervous system (ANS) dysfunction in Huntington's disease (HD) might affect both the sympathetic and parasympathetic branch of the ANS.


CONCLUSIONS
The pattern of linear heart rate variability we found in mid stage HD patients points towards a predominately reduced cardiovagal modulation compared with healthy subjects, which might influence HD patients' susceptibility for cardiovascular complications such as syncopes and cardiac arrhythmias.
Bär
K J
KJ
Department of Psychiatry, Friedrich-Schiller-University, Jena, Germany. Karl-Juergen.Baer@med.uni-jena.de
Boettger
M K
MK
Andrich
J
J
Epplen
J T
JT
Fischer
F
F
Cordes
J
J
Koschke
M
M
Agelink
M W
MW
D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000294:innervation / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011187:Posture / Q000502:physiology*; D018667:Tilt-Table Test; D014630:Vagus Nerve / Q000503:physiopathology