title: Silacyclic derivatives of heteroaromatic sulfides as selective cholesterol level lowering and vasodilating agents.
abstract: Silacyclic derivatives of heteroaromatic sulfides have been prepared by using phase transfer catalytic (PTC) system thiol / silacyclopropyl iodide / solid K(2)CO(3) / 18-crown-6 / toluene. The target sulfides were isolated in yields up to 70 %. The S-derivatives of N-methylimidazolyl, benzoxazolyl and 1,3,4-triazolyl thiols selectively lowered the low density lipoprotein (LDL) level in mice with the high cholesterol diet in nutrition.
authors.affiliation: Latvian Institute of Organic Synthesis 21 Aizkraukles street Riga LV-1006 Latvia.
authors.forename: Edgars
authors.initials: E
authors.lastname: Abele
authors.forename: Kira
authors.initials: K
authors.lastname: Rubina
authors.forename: Ramona
authors.initials: R
authors.lastname: Abele
authors.forename: Olegs
authors.initials: O
authors.lastname: Dzenitis
authors.forename: Pavel
authors.initials: P
authors.lastname: Arsenyan
authors.forename: Juris
authors.initials: J
authors.lastname: Popelis
authors.forename: Maris
authors.initials: M
authors.lastname: Veveris
authors.forename: Dainuvite
authors.initials: D
authors.lastname: Meirena
authors.forename: Edmunds
authors.initials: E
authors.lastname: Lukevics