Essramycin: a first triazolopyrimidine antibiotic isolated from nature.
In the course of our screening program for new bio-active compounds, a novel triazolopyrimidine antibiotic, essramycin (1), was obtained from the culture broth of the marine Streptomyces sp., isolate Merv8102. Structure 1 was established by intensive NMR studies and by mass spectra. The compound is antibacterially active with MIC of 2 to 8 microg/ml against Gram-positive and Gram-negative bacteria, while it showed no antifungal activity. The fermentation and isolation, as well as the structure elucidation and biological activity of 1 are described.
El-Gendy
Mervat M A
MM
Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical Industries, National Research Centre, Dokki-Cairo, Egypt.
Shaaban
Mohamed
M
Shaaban
Khaled A
KA
El-Bondkly
Ahmed M
AM
Laatsch
Hartmut
H
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D005285:Fermentation; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D008970:Molecular Weight; D011743:Pyrimidines / Q000302:isolation & purification / Q000494:pharmacology*; D011744:Pyrimidinones; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*; D014230:Triazoles / Q000302:isolation & purification / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D011743:Pyrimidines; D011744:Pyrimidinones; D014230:Triazoles; C532326:essramycin