title: Are individuals with severe haemophilia A prone to reduced bone density?
abstract: Individuals with severe haemophilia A may be at risk for reduced bone mineral density because of reduced weight-bearing exercise and hepatitis C infection. For confirming the reduced bone density, in the current cross-sectional study, we tried to address bone mineral density in individuals with severe haemophilia A and surveyed the relation of reduced bone density with hepatitis C viruses. To fulfil these aims, bone density and biochemical indexes in 18 individuals with severe haemophilia A and also in 18 individuals matched for age, sex, weight and height, as the control group, were examined. The obtained results showed that individuals with severe haemophilia A had reduced bone density (1.136 +/- 0.118, 0.801 +/- 0.238) in lumbar and femur regions, respectively, in comparison with the age- and sex-matched group (1.299 +/- 0.237, 1.458 +/- 0.505). The major complications of coagulation disorders are various types of excessive bleeding. The current study describes an association between severe haemophilia A and osteopenia, specifically at both the femur and the lumbar spine.
authors.affiliation: Immunology Research Center, Ghaem Hospital, 91766-99199 Mashhad, Iran. mansouritorghabe@mums.ac.ir
authors.forename: Hassan
authors.initials: H
authors.lastname: Mansouritorghabeh
authors.forename: Zahra
authors.initials: Z
authors.lastname: Rezaieyazdi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Badiei
mesh_terms: D000328:Adult; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000150:complications* / Q000821:virology; D016022:Case-Control Studies; D006467:Hemophilia A / Q000150:complications* / Q000821:virology; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D008875:Middle Aged; D055815:Young Adult