title: Association between MBL2 gene functional polymorphisms and high-risk human papillomavirus infection in Brazilian women.
abstract: We studied the association between high-risk human papillomavirus (HPV) infection and MBL2 functional polymorphisms in a group of 180 high-risk HPV-infected women and 180 healthy control subjects. The most frequent high-risk HPV genotypes were 16 (47.2%), 31 (11.7%), 33 (5%), and 18 (2.2%), respectively. Of the 180 HPV-infected women, 99 presented with uterine cervical cancer and 81 did not. No differences in MBL2 genotype or in allelic or haplotype frequencies were found between HPV patients who developed cervical uterine cancer and those who did not. When considering combined genotypes grouped according to MBL production (designated as high, low, and deficient producers), we detected a significant difference between healthy controls and high-risk HPV-positive patients, the latter group showing increased frequencies of deficient-producer genotypes (14.4% vs 9.4% in the healthy control group, corrected p = 0.04). In conclusion, a correlation between MBL2 polymorphisms and high-risk HPV infection was found in this study.
authors.affiliation: Gynecological Unit, Instituto Materno Infantil Prof. Fernando Figueira, Recife, Brazil.
authors.forename: Vilma
authors.initials: V
authors.lastname: Guimaraes
authors.forename: Rafael
authors.initials: R
authors.lastname: Guimaraes
authors.forename: Lucas
authors.initials: L
authors.lastname: Brandao
authors.forename: Maria Fernanda Piffer Tomasi
authors.initials: MF
authors.lastname: Baldez da Silva
authors.forename: Michele
authors.initials: M
authors.lastname: Milanese
authors.forename: Ludovica
authors.initials: L
authors.lastname: Segat
authors.forename: Henrique
authors.initials: H
authors.lastname: Castelletti
authors.forename: Danielly
authors.initials: D
authors.lastname: Bruneska
authors.forename: Josè Luiz
authors.initials: JL
authors.lastname: de Lima Filho
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: de Freitas
authors.forename: Luiz Claudio
authors.initials: LC
authors.lastname: Arraes
authors.forename: Cintia
authors.initials: C
authors.lastname: Rocha
authors.forename: Sergio
authors.initials: S
authors.lastname: Crovella
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D052162:Human papillomavirus 16; D006801:Humans; D037601:Mannose-Binding Lectin / Q000235:genetics*; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012306:Risk; D017422:Sequence Analysis, DNA; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000235:genetics*
chemical_list: C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin