Desorption ionization of biomolecules on metals.
Direct desorption ionization of various types of biomolecules on metal substrates without the need of matrices was observed by a time-of-flight mass spectrometer. It provides a new convenient method for detection of small biomolecules without the confusion of ion peaks from matrix compounds. Simple commercial Al foil can be used as the substrate to obtain mass spectra of biomolecules without the need of an etching process to produce a porous surface such as with direct ionization on silicon (DIOS). The desorption and ionization mechanism is also discussed.
Hsu
Nien-Yeen
NY
Department of Chemistry and Chemical Biology, National Taiwan University, Taipei, Taiwan, Republic of China.
Tseng
Susan Yu
SY
Wu
Chung-Yi
CY
Ren
Chien-Tai
CT
Lee
Yuan-Chang
YC
Wong
Chi-Huey
CH
Chen
Chung-Hsuan
CH
D000535:Aluminum / Q000737:chemistry*; D000537:Aluminum Oxide / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry*; D053844:Lasers, Solid-State; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D009841:Oligonucleotides / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*
D005227:Fatty Acids; D009841:Oligonucleotides; D010455:Peptides; D011134:Polysaccharides; D000535:Aluminum; D000537:Aluminum Oxide