Familial alopecia areata and chronic thrombocytopenia.
Alopecia areata (AA) has a strong hereditary component and is associated with a number of other autoimmune diseases. There is no established relationship between AA and any of the congenital thrombocytopenias. We report a family in which multiple members are affected with AA and with a hereditary thrombocytopenia, most consistent with pseudo-von Willebrand disease. This raises the possibility of a genetic association between AA and one or more of the inherited thrombocytopenias, possibly both related to mutations in genes on chromosome 17.
Ahmed
Ammar M
AM
Baylor College of Medicine, Houston, Texas, USA.
Barahmani
Nazila
N
Duvic
Madeleine
M
D000506:Alopecia Areata / Q000150:complications* / Q000235:genetics*; D002908:Chronic Disease; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D013921:Thrombocytopenia / Q000150:complications* / Q000235:genetics*