title: Filaggrin mutations and allergic contact sensitization.
abstract: In this issue, Novak et al. (2008) provide evidence that filaggrin barrier defects might also predispose to allergic contact dermatitis by allowing greater penetration of chemical haptens. Their report provides a fresh perspective on the issues of contact allergy, nickel sensitization, and stratum corneum defects.
authors.affiliation: Department of Dermatology, Oregon Health and Science University, Center for Health and Healing, Portland, Oregon 97239, USA. hanifinj@ohsu.edu
authors.forename: Jon M
authors.initials: JM
authors.lastname: Hanifin
mesh_terms: D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000235:genetics*; D003876:Dermatitis, Atopic; D004485:Eczema / Q000473:pathology; D000091344:Filaggrin Proteins; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D006969:Hypersensitivity, Immediate; D007249:Inflammation; D007381:Intermediate Filament Proteins / Q000235:genetics*; D008954:Models, Biological; D009154:Mutation; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology*; D010328:Patch Tests; D012867:Skin / Q000276:immunology / Q000473:pathology
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D009532:Nickel