title: [Expression of OCTN2 mRNA in the human epididymis and its significance].
abstract: OBJECTIVE
  To explore the mechanism of L-Carnitine transport and the expression of OCTN2 mRNA in the human epididymis so as to provide a theoretical basis for male contraception.
  
  
  METHODS
  We collected specimens from human epididymides and determined the expressions of OCTN2 mRNA in the caput, corpus and cauda of the epididymis by RT-PCR.
  
  
  RESULTS
  OCTN2 mRNA was expressed in the caput, corpus and cauda of the epididymis.
  
  
  CONCLUSIONS
  The human epididymis may rely on OCTN2 for transporting L-Carnitine into the epididymal duct to promote sperm maturation. With the accumulation of information on OCTN2 in the human epididymis, OCTN2 will become a new molecular target for researches on male contraception.
authors.affiliation: Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China. gongdongming@126.com
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Gong
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Zhu
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Liu
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Cao
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Wang
mesh_terms: D003267:Contraception / Q000379:methods; D004822:Epididymis / Q000378:metabolism*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D027701:Organic Cation Transport Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000074058:Solute Carrier Family 22 Member 5
chemical_list: D027701:Organic Cation Transport Proteins; D012333:RNA, Messenger; C492020:SLC22A5 protein, human; D000074058:Solute Carrier Family 22 Member 5