title: Rosai-Dorfman disease following bone marrow transplantation for pre-B cell acute lymphoblastic leukemia.
abstract: A child with acute pre-B cell lymphoblastic leukemia underwent haploidentical bone marrow transplantation (BMT) after first relapse. Approximately 8 months after the BMT, he developed a soft tissue mass overlying a defect in the left frontal bone. He was found to have several additional osteolytic lesions but no evidence of lymphadenopathy or organomegaly. A biopsy of the presenting lesion demonstrated a polymorphous infiltrate composed predominantly of S-100 protein and CD68 immunoreactive histiocytic cells. Together with the presence of emperipolesis, the process was interpreted as Rosai-Dorfman (R-D) disease. He received chemotherapy with vinblastine, prednisone, 6-mercaptopurine and methotrexate and has been in remission for over 4 years. Only one previous example of acute lymphoblastic leukemia in childhood has been reported with R-D disease.
authors.affiliation: Department of Pediatrics, Miami Children's Hospital, Miami, Florida 33155, USA. srikanth.ambati@mch.com
authors.forename: S
authors.initials: S
authors.lastname: Ambati
authors.forename: G
authors.initials: G
authors.lastname: Chamyan
authors.forename: R
authors.initials: R
authors.lastname: Restrepo
authors.forename: E
authors.initials: E
authors.lastname: Escalon
authors.forename: J
authors.initials: J
authors.lastname: Fort
authors.forename: A
authors.initials: A
authors.lastname: Pefkarou
authors.forename: Z A
authors.initials: ZA
authors.lastname: Khatib
authors.forename: Louis P
authors.initials: LP
authors.lastname: Dehner
mesh_terms: D000293:Adolescent; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D017809:Fatal Outcome; D006086:Graft vs Host Disease / Q000209:etiology*; D006644:Histiocytes; D015618:Histiocytosis, Sinus / Q000209:etiology*; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000628:therapy; D012074:Remission Induction; D009418:S100 Proteins; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule