Isolation and biological activities of termilignan B and arjunic acid from Terminalia sericea roots.
Bioassay-guided fractionation of ethyl acetate root extracts of Terminalia sericea yielded a new compound, termilignan B, and the known arjunic acid. Both compounds showed activity against Gram-positive and Gram-negative bacteria with MIC values ranging between 1.9 and 15.6 microg/mL. The lowest MIC value (1.9 microg/mL) was observed with termilignan B against Bacillus subtilis. Neither of the compounds showed significant activity against Mycobacterium aurum A+. In the cyclooxygenase assays, the compounds showed weak inhibitory activity with IC (50) values of 78 microM (COX-1) and 156 microM (COX-2) (termilignan B) and 36 microM (COX-1) and 253 microM (COX-2) (arjunic acid). No potential mutagenic effects were observed with the two compounds in the Salmonella microsome assay (TA 98).
Eldeen
Ibrahim M
IM
Research Centre for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu-Natal Pietermaritzburg, South Africa.
Van Heerden
Fanie R
FR
Van Staden
Johannes
J
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D029766:Terminalia / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D016861:Cyclooxygenase Inhibitors; D014315:Triterpenes; C441431:arjunic acid; C532560:termilignan B