Serum and urine levels of interleukin-8 in patients with non-Hodgkin's lymphoma.
Angiogenesis plays an important role in many types of cancer. Interleukin-8 (IL-8) is known to be a pro-inflammatory and pro-angiogenic cytokine, and IL-8 has been reported to be associated with tumor progression, prognosis and survival in several types of cancers. However, the role of IL-8 in non-Hodgkin's lymphoma (NHL) has not been fully determined. Here, we evaluated the usefulness of measuring serum and urine IL-8 levels in patients with NHL. We developed reference intervals for serum and urine IL-8 level in 131 control individuals. We measured serum IL-8 and urine IL-8 levels in patients with NHL, and we compared the concentrations with those of control individuals. The reference intervals for serum IL-8 and urine IL-8 corrected by creatinine (Cr) were 15.9-430.3 pg/mL and 0.0-28.4 pg/mg Cr, respectively. The concentrations of urine IL-8/Cr were significantly higher in patients than in controls (48.9+/-194.4 vs. 5.2+/-13.8 pg/mg Cr, P<0.001). However, there were no significant differences in serum IL-8 concentrations between NHL patients and controls (159.2+/-40.4 vs. 99.6+/-107.1 pg/mL; P=0.099). Receiver operating characteristic (ROC) analysis gave 0.83 and 0.43 ROC area values for urine IL-8/Cr and serum IL-8, respectively. There was no correlation between the serum and urine concentrations of IL-8 and clinical variables, the only exception being the international prognostic index (IPI), which showed a marginal correlation with urine IL-8/Cr levels (P=0.07). This study indicated that urine IL-8/Cr levels might be useful as a diagnostic marker of NHL.
Lee
Hye Lin
HL
Hematologic Malignancies Branch, Division of Translational & Clinical Research II, Research Institute & Hospital, National Cancer Center, 809 Madu-dong, Ilsan-gu, Goyang-si, Gyeonggi-do 410-769, Republic of Korea.
Eom
Hyeon-Seok
HS
Yun
Tak
T
Kim
Hyun-Ju
HJ
Park
Weon-Seo
WS
Nam
Byung-Ho
BH
Moon-Woo
Seong
S
Lee
Do-Hoon
DH
Kong
Sun-Young
SY
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood* / Q000652:urine*; D003404:Creatinine / Q000097:blood / Q000592:standards / Q000652:urine; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood* / Q000592:standards / Q000652:urine*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000175:diagnosis / Q000652:urine*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012074:Remission Induction
D014408:Biomarkers, Tumor; D016209:Interleukin-8; D003404:Creatinine