title: A case of mixed connective tissue disease complicated with hypertrophic obstructive cardiomyopathy.
abstract: A 54-year-old female was diagnosed as mixed connective tissue disease (MCTD) complicated with secondary Sjögren's syndrome. Although she had no dyspnea on exertion, the chest X-ray showed cardiomegaly with interstitial pneumonia. The echocardiogram demonstrated asymmetric hypertrophy of the interventricular septum. Diagnosis of hypertrophic obstructive cardiomyopathy (HOCM) was confirmed by left ventriculography and myocardial biopsy. She was treated with prednisolone, resulting in improvement of swollen hand, elevated muscle enzymes and interstitial pneumonia. A rare complication of HOCM with MCTD was described.
authors.affiliation: First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki City, Nagasaki 852-8501, Japan. nakamura_hideki911@yahoo.co.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Seiko
authors.initials: S
authors.lastname: Tateishi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ida
authors.forename: Taku
authors.initials: T
authors.lastname: Fukuda
authors.forename: Michiyo
authors.initials: M
authors.lastname: Sasaki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Koide
authors.forename: Naoto
authors.initials: N
authors.lastname: Ashizawa
authors.forename: Shinji
authors.initials: S
authors.lastname: Seto
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D015804:HLA-DR4 Antigen / Q000276:immunology; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000209:etiology; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D012859:Sjogren's Syndrome / Q000150:complications* / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D015804:HLA-DR4 Antigen; D011239:Prednisolone