Acid cleavable PEG-lipids for applications in a ternary gene delivery vector.
A novel class of pH-sensitive PEG lipids bearing acid-cleavable acetal linkages and short PEG chains have been synthesised and used in ternary vector formulations. The cleavage pH was influenced by structural components including the terminal PEG moiety and spacer length.
Wong
John B
JB
Department of Chemistry, University College London, 20 Gordon Street, London, UK.
Grosse
Stephanie
S
Tabor
Alethea B
AB
Hart
Stephen L
SL
Hailes
Helen C
HC
D000143:Acids / Q000737:chemistry*; D002478:Cells, Cultured; D004247:DNA / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D018014:Gene Transfer Techniques; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000138:chemical synthesis / Q000737:chemistry* / Q000235:genetics; D015394:Molecular Structure; D010957:Plasmids / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D014162:Transfection
D000143:Acids; D004337:Drug Carriers; D008055:Lipids; D011092:Polyethylene Glycols; D004247:DNA