MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not.
The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(-1306T) and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-9 levels were associated with poor prognosis but SNP MMP-9(-1562C>T) was not. Tumour MMP levels were not determined by their SNP genotypes.
Langers
A M J
AM
Department of Gastroenterology-Hepatology, Leiden University Medical Centre, Leiden, The Netherlands.
Sier
C F M
CF
Hawinkels
L J A C
LJ
Kubben
F J G M
FJ
van Duijn
W
W
van der Reijden
J J
JJ
Lamers
C B H W
CB
Hommes
D W
DW
Verspaget
H W
HW
D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000401:mortality; D005838:Genotype; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011401:Promoter Regions, Genetic
D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9