title: A cyclic RGD-coated peptide nanoribbon as a selective intracellular nanocarrier.
abstract: We have synthesized a peptide-based supramolecular building block consisting of a cyclic Arg-Gly-Asp (cRGD) peptide segment and a beta-sheet-forming peptide segment. The block peptide was shown to self-assemble into a cRGD-coated nanoribbon structure, as revealed by circular dichroism (CD), dynamic light scattering (DLS), and transmission electron microscopy (TEM) studies. We have shown that this cRGD-coated nanoribbon can encapsulate hydrophobic guest molecules and deliver them into cells. Colocalization of the nanoribbon with LysoTracker and the selective intracellular delivery results suggests that the cRGD-coated nanoribbon is likely to be internalized into the cells through integrin receptors.
authors.affiliation: Centre for Supramolecular Nano-Assembly, Department of Chemistry, Yonsei University, Shinchon 134, Seoul 120-749, Korea.
authors.forename: Yong-Beom
authors.initials: YB
authors.lastname: Lim
authors.forename: Oh-Joon
authors.initials: OJ
authors.lastname: Kwon
authors.forename: Eunji
authors.initials: E
authors.lastname: Lee
authors.forename: Pyung-Hwan
authors.initials: PH
authors.lastname: Kim
authors.forename: Chae-Ok
authors.initials: CO
authors.lastname: Yun
authors.forename: Myongsoo
authors.initials: M
authors.lastname: Lee
mesh_terms: D000595:Amino Acid Sequence; D002942:Circular Dichroism; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D046529:Microscopy, Electron, Transmission; D008969:Molecular Sequence Data; D049329:Nanostructures; D009842:Oligopeptides / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry*
chemical_list: D009842:Oligopeptides; D010456:Peptides, Cyclic; C047981:arginyl-glycyl-aspartic acid