title: Synthesis, characterization and high in vitro antitumour activity of novel triphenyltin carboxylates.
abstract: The synthesis and spectral characterization of six novel triphenyltin compounds are described. The in vitro antitumour activity of three of these compounds against two human tumour cell lines, MCF-7, a mammary tumour, and WiDr, a colon carcinoma, was determined. All three compounds are more active than cis-platin, etoposide and doxorubicin against both tumour cell lines. They are as active as mitomycin C against WiDr, but less active against MCF-7.
authors.affiliation: Free University of Brussels (V.U.B.) Pleinlaan 2 Faculty of Applied Sciences Laboratory for General and Organic Chemistry (AOSC), Room 8G512 Brussels B-1050 Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Gielen
authors.forename: A
authors.initials: A
authors.lastname: El Khloufi
authors.forename: M
authors.initials: M
authors.lastname: Biesemans
authors.forename: A
authors.initials: A
authors.lastname: Bouhdid
authors.forename: D
authors.initials: D
authors.lastname: de Vos
authors.forename: B
authors.initials: B
authors.lastname: Mahieu
authors.forename: R
authors.initials: R
authors.lastname: Willem