title: Paired receptor systems of the innate immune system.
abstract: This appendix describes paired receptors involved in the innate immune system. "Paired Receptors" are defined as families of related membrane proteins that show the following characteristics: (1) they are encoded by different genes, but located as a gene cluster on a given chromosome; (2) they have significant homology within their extracellular domains; (3) they are expressed on overlapping immune populations; and (4) they are confirmed to have both activating and inhibitory members. For simplicity in nomenclature, the authors used the official gene nomenclature provided by NCBI and listed all other names in the alias field. Paired receptor information related to both mouse and human systems is included, as some families exist in both species whereas others are important in the study of either human or murine models of disease.
authors.affiliation: Cancer and Inflammation Program, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland.
authors.forename: Eriko
authors.initials: E
authors.lastname: Yamada
authors.affiliation: Cancer and Inflammation Program, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland.
authors.forename: Daniel W
authors.initials: DW
authors.lastname: McVicar
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D005810:Multigene Family; D017434:Protein Structure, Tertiary; D011971:Receptors, Immunologic / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D009626:Terminology as Topic
chemical_list: D011971:Receptors, Immunologic