A plaidoyer for cutaneous enzymology: our view of some important unanswered questions on the contributions of selected key enzymes to epidermal homeostasis.
This review highlights the importance of enzymology, a field of great neglect in current cutaneous biology research. It was therefore the aim by using selected examples of epidermal enzymes and their action including some open questions to demonstrate the importance of this area. Clearly a thorough understanding of basic knowledge in this field is needed which in turn offers a plethora of innovative research projects for a curious mind. Moreover, in order to gain the closest understanding to the truth instead of generating esoteric results, emphasis is put forward on a holistic view utilizing a combination of modern and sometimes old methods to get the answer. Last but not least the bench work is only useful for the welfare of our patients if we can apply our basic knowledge.
Wood
John M
JM
Department of Biomedical Sciences, Clinical and Experimental Dermatology, School of Life Sciences, University of Bradford, Bradford, UK.
Schallreuter
Karin U
KU
D000975:Antioxidants / Q000378:metabolism*; D001708:Biopterins / Q000031:analogs & derivatives / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D004817:Epidermis / Q000201:enzymology* / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015603:Keratinocytes / Q000201:enzymology*; D008544:Melanocytes / Q000201:enzymology*; D009490:Neurosecretory Systems / Q000201:enzymology; D012879:Skin Physiological Phenomena
D000975:Antioxidants; D001708:Biopterins; C003402:sapropterin; D002118:Calcium