Lycoparins A-C, new alkaloids from Lycopodium casuarinoides inhibiting acetylcholinesterase.
Three new Lycopodium alkaloids, lycoparins A-C (1-3), have been isolated from the club moss Lycopodium casuarinoides. Structures and stereochemistry of 1-3 were elucidated on the basis of 2D NMR correlations. Lycoparins C (3) exhibited an inhibitory activity against acetylcholinesterase, while lycoparins A (1) and B (2) did not show activity.
Hirasawa
Yusuke
Y
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
Kato
Eri
E
Kobayashi
Jun'ichi
J
Kawahara
Nobuo
N
Goda
Yukihiro
Y
Shiro
Motoo
M
Morita
Hiroshi
H
D000110:Acetylcholinesterase / Q000097:blood; D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004912:Erythrocytes / Q000201:enzymology; D006868:Hydrolysis / Q000187:drug effects; D032502:Lycopodium / Q000737:chemistry*; D015363:Quinolones / Q000302:isolation & purification* / Q000494:pharmacology*
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D015363:Quinolones; C531105:lycoparin A; C531107:lycoparin B; C531106:lycoparin C; D000110:Acetylcholinesterase