14-3-3 proteins: a family of versatile molecular regulators.
The 14-3-3 proteins are a family of acidic regulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. Through the functional modulation of a wide range of binding partners, 14-3-3 proteins are involved in many processes, including cell cycle regulation, metabolism control, apoptosis, and control of gene transcription. This minireview includes a short overview of 14-3-3 proteins and then focuses on their role in the regulation of two important binding partners: FOXO forkhead transcription factors and an enzyme tyrosine hydroxylase.
Obsilová
V
V
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic. obsil@natur.cuni.cz
Silhan
J
J
Boura
E
E
Teisinger
J
J
Obsil
T
T
D048948:14-3-3 Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D011487:Protein Conformation; D020033:Protein Isoforms; D020836:Protein Structure, Quaternary; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D048948:14-3-3 Proteins; D051858:Forkhead Transcription Factors; D020033:Protein Isoforms; D014446:Tyrosine 3-Monooxygenase