title: [Reduction of oxaliplatin-related neurotoxicity by Gosha-jinki-gan].
abstract: OBJECTIVE
  Oxaliplatin in combination with infusional 5-fluorouracil/Leucovorin (FOLFOX) has emerged as the treatment of choice for advanced-stage colorectal cancer. Sensory neurotoxicity is its dose-limiting toxicity. We decided to use Gosha-jinki-gan for prevention of oxaliplatin-related neurotoxicity following the report of Fushiki et al.
  
  
  METHODS
  The subjects were 14 patients with metastatic colorectal cancer. Oxaliplatin (85 mg/m(2)) was given intravenously as a FOLFOX4 regimen. All 14 patients received Gosha-jinki-gan every day after first oxaliplatin infusion.
  
  
  RESULTS
  7 patients had grade 3 toxicity(neutropenia 6, thrombocytopenia 1). Sensory neuropathy occurred in 10 patients (71.4%). There was no neurotoxicity with functional impairment in this study.
  
  
  CONCLUSIONS
  Gosha-jinki-gan seems to prevent acute oxaliplatin-induced neurotoxicity.
authors.affiliation: Dept. of Surgery, Ogachi Chuo Hospital.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Shindo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tenma
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imano
authors.forename: Masanori
authors.initials: M
authors.lastname: Hibino
authors.forename: Kei
authors.initials: K
authors.lastname: Yoshino
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000633:toxicity*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000633:toxicity; D015179:Colorectal Neoplasms / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000633:toxicity; D006801:Humans; D002955:Leucovorin / Q000633:toxicity; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000633:toxicity*; D000077150:Oxaliplatin; D010525:Peripheral Nerves / Q000187:drug effects*; D010523:Peripheral Nervous System Diseases / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D009944:Organoplatinum Compounds; C119642:gosha-jinki-gan; D000077150:Oxaliplatin; D002955:Leucovorin; D005472:Fluorouracil