Pulmonary arteriovenous malformations: percutaneous treatment preserving parenchyma in high-flow fistulae.
OBJECTIVE
The aim of our study was to illustrate the benefits of percutaneous treatment by embolisation of high-flow pulmonary arteriovenous malformations (PAVM) in patients suffering from hereditary haemorrhagic telangiectasia (HHT; Rendu-Osler-Weber disease).


METHODS
From December 2001 to February 2007, we embolised 60 PAVMS in 35 procedures performed on 30 patients, all referred by the HHT centre in Crema, and enrolled in a screening programme of HHT families. All patients underwent clinical evaluation, contrast-enhanced ultrasound (CEUS) and spiral computed tomography (CT). Embolisation was made with nonmagnetic metallic coils via femoral venous access; an endovascular Amplatzer device was used in one patient only.


RESULTS
All embolisations were performed without difficulty. One patient only developed partial temporary aphasia, which resolved in 72 H. At spiral-CT follow-up, we generally demonstrated exclusion from circulation of treated PAVMS and regression of clinical symptoms. In the case of new lesions or recanalisation, further embolisation was possible:


CONCLUSIONS
Percutaneous embolisation has recently become the initial treatment option in PAVM owing to its good results and minimal invasiveness compared with thoracotomy. Our experience is in agreement with the literature: the procedure has a low complication rate, provides very good technical and clinical results and avoids resection of healthy pulmonary parenchyma.
Grosso
M
M
Dipartimento Radiologico, S.C. Radiodiagnostica, Azienda Ospedaliera S.Croce e Carle, Via Coppino 26, Cuneo, Italy. grosso.m@ospedale.cuneo.it
Groppo Marchisio
F
F
Testa
F
F
Gallarato
G
G
Balderi
A
A
Lingua
G
G
Mondino
I
I
Pedrazzini
F
F
Danesino
C
C
Buscarini
E
E
D000328:Adult; D000368:Aged; D001164:Arteriovenous Fistula / Q000209:etiology / Q000628:therapy*; D001165:Arteriovenous Malformations / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000002:abnormalities*; D011667:Pulmonary Veins / Q000002:abnormalities*; D012189:Retrospective Studies; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000150:complications* / Q000000981:diagnostic imaging; D036542:Tomography, Spiral Computed; D016896:Treatment Outcome; D014463:Ultrasonography