title: Pd(II)-catalyzed cross-coupling of sp3 C-H Bonds with sp2 and sp3 boronic acids using air as the oxidant.
abstract: O-Methyl hydroxamic acids, readily available from carboxylic acids, are found to be extremely reactive for beta-C-H activation by Pd(OAc)2. This reactivity is exploited to develop the first example of cross-coupling sp3 C-H bonds with sp3 boronic acids. Air was shown to be a suitable stoichiometric oxidant for the catalytic oxidative coupling reaction. A biologically active natural product is readily converted to its novel analogues through this coupling reaction.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Dong-Hui
authors.initials: DH
authors.lastname: Wang
authors.forename: Masayuki
authors.initials: M
authors.lastname: Wasa
authors.forename: Ramesh
authors.initials: R
authors.lastname: Giri
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D000388:Air; D001897:Boronic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D009930:Organic Chemicals / Q000138:chemical synthesis*; D016877:Oxidants / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry
chemical_list: D001897:Boronic Acids; D009930:Organic Chemicals; D016877:Oxidants; D010165:Palladium