Primary leptomeningeal B-cell lymphoma of MALT-type in statu nascendi: a case report and review of the literature.
A 29-year-old Caucasian female suffering from bipolar disorder, mixed, moderate with psychotic features (DSM-IV 296.64) and panic disorder without agoraphobia (DSM-IV 300.01) died as a result of an accidental overdose. Upon histopathological examination of the brain, as an incidental finding, a small lesion (1mm x 2mm) composed of heterogeneous small lymphocytic cells (CD20-positive) including centrocyte-like cells, a few small lymphocytes and rare immunoblast-like cells was evident. The diagnosis of primary leptomeningeal MALT-type lymphoma was made. Due to its small size and lack of space-occupying characteristics, the lesion is considered to be in statu nascendi. This case adds another aspect to the rare entity of primary leptomeningeal lymphomas.
Weis
Serge
S
Stanley Laboratory for Brain Research and Neuropathology, Department of Psychiatry, Uniformed Services University of the Health Sciences and Stanley Medical Research Institute, Bethesda, MD, USA. serge.weis@gespag.at
Llenos
Ida C
IC
D000328:Adult; D018951:Antigens, CD20 / Q000032:analysis; D001344:Autopsy; D001921:Brain / Q000378:metabolism / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis*; D008577:Meningeal Neoplasms / Q000175:diagnosis*
D018951:Antigens, CD20