title: Three new antimicrobial metabolites of Phomopsis sp.
abstract: Two new 10-membered macrolides, named Phomolides A (1) and B (2), and one new derivative of benzofuran (3) were isolated from the culture of Phomopsis sp. hzla01-1, and their structures were elucidated based on spectroscopic analyses, particularly 2D NMR experiments. Compounds 1, 2 and 3 showed significant antimicrobial activities against Escherichia coli CMCC44103, Candida albicans AS2.538, Saccharomyces cerevisiae ATCC9763 with MICs 5~10 mug/ml. The most significant, compound 3 showed strong activity against Bacillus subtilis CMCC63501 with the MIC value 1.25 microg/ml. None of the three compounds showed significant cytotoxicity against the HeLa cell line at 10 microg/ml.
authors.affiliation: Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen University, China.
authors.forename: Xiping
authors.initials: X
authors.lastname: Du
authors.forename: Chunhua
authors.initials: C
authors.lastname: Lu
authors.forename: Yaoyao
authors.initials: Y
authors.lastname: Li
authors.forename: Zhonghui
authors.initials: Z
authors.lastname: Zheng
authors.forename: Wenjin
authors.initials: W
authors.lastname: Su
authors.forename: Yuemao
authors.initials: Y
authors.lastname: Shen
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C530713:3-(hydroxymethyl)-6-methyl-6,7-dihydrobenzofuran-4(5H)-one; D000890:Anti-Infective Agents; D001572:Benzofurans; D004852:Epoxy Compounds; D007783:Lactones; D018942:Macrolides; C530711:phomolide A; C530712:phomolide B