Health behaviors and psychological distress in women initiating BRCA1/2 genetic testing: comparison with control population.
The study objective was to compare breast cancer screening practices, lifestyle behaviors and psychological distress among 640 women initiating BRCA1/2 testing to those among 9,498 similarly-aged women from the general population. Health behaviors and psychological distress were reported in a self-administered questionnaire at pre-test genetic counseling. Regression analyses indicate that high-risk women were more frequently performing breast cancer screening and, in the case of those previously diagnosed with cancer, were more likely to be non-smokers and physically active than women from general population. However, women initiating BRCA1/2 testing were significantly more distressed than controls. Globally, high-risk women seemed to be well informed about recommendations for women who are at high risk and to have access to screening adapted to their risk level. Given their significant psychological distress, providing minimal psychosocial support to all women undergoing BRCA1/2 testing at pre-test genetic counseling is relevant.
Dorval
Michel
M
Faculté de pharmacie, Université Laval, Québec, Canada. mdorval@uresp.ulaval.ca
Bouchard
Karine
K
Maunsell
Elizabeth
E
Plante
Marie
M
Chiquette
Jocelyne
J
Camden
Stéphanie
S
Dugas
Michel J
MJ
Simard
Jacques
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000523:psychology*; D015438:Health Behavior; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D012044:Regression Analysis; D013315:Stress, Psychological; D011795:Surveys and Questionnaires