Prevalence of celiac disease in children with type 1 diabetes mellitus increased in the mid-1990 s: an 18-year longitudinal study based on anti-endomysial antibodies.
Between 1987 and 2004, 331 consecutive children, all newly diagnosed with type 1 diabetes mellitus in our pediatric clinic, underwent repeated serological screening for celiac disease (CD) by means of anti-endomysial antibodies, measured prospectively between 1994 and 2004, and retrospectively, using frozen banked serum, between 1987 and 1993. There were 22 cases (6.6%) of biopsy-proven CD among the 331 diabetic children. The prevalence of CD was significantly (P = 0.015) higher after 1994 (10.6%) than before 1994 (3.3%). The rapid change in the risk of CD among Italian diabetic children that occurred in the mid-1990 s could be related to changes in environmental factors, namely, eating habits and viral infections.
Salardi
Silvana
S
Departments of Pediatrics, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy. silvana.salardi@unibo.it
Volta
Umberto
U
Zucchini
Stefano
S
Fiorini
Erica
E
Maltoni
Giulio
G
Vaira
Bernardino
B
Cicognani
Alessandro
A
D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000453:epidemiology*; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008403:Mass Screening / Q000379:methods; D015995:Prevalence; D012698:Serologic Tests
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies