title: Regulation of gene expression by the RNA-binding protein Sam68 in cancer.
abstract: Sam68 (Src-associated in mitosis 68 kDa) is the prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. Sam68 is implicated in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the present review, we summarize the functions of Sam68 as a transcriptional and post-transcriptional regulator of gene expression, with particular relevance to cancer.
authors.affiliation: Institute of Human Genetics, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK. prabs_rajan@yahoo.co.uk
authors.forename: Prabhakar
authors.initials: P
authors.lastname: Rajan
authors.forename: Luke
authors.initials: L
authors.lastname: Gaughan
authors.forename: Caroline
authors.initials: C
authors.lastname: Dalgliesh
authors.forename: Amira
authors.initials: A
authors.lastname: El-Sherif
authors.forename: Craig N
authors.initials: CN
authors.lastname: Robson
authors.forename: Hing Y
authors.initials: HY
authors.lastname: Leung
authors.forename: David J
authors.initials: DJ
authors.lastname: Elliott
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D012323:RNA Processing, Post-Transcriptional; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D016601:RNA-Binding Proteins