Endothelial signalling by Ig-like cell adhesion molecules.
Leukocyte transendothelial migration is controlled by chemokine-induced signalling in leukocytes and integrin-ligand-induced bidirectional signalling in both leukocytes and endothelial cells. It is now generally accepted that endothelial signalling following leukocyte adhesion, serves to facilitate the crossing of the endothelium, be it via the paracellular or transcellular route. This brief overview discusses the main findings within this area and highlights some recent findings that shed new light on adhesion-induced signalling in the context of leukocyte transendothelial migration.
van Buul
J D
JD
Sanquin Research and Landsteiner Laboratory, Department Molecular Cell Biology, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.
Hordijk
P L
PL
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D007136:Immunoglobulins / Q000502:physiology; D018799:Intercellular Adhesion Molecule-1 / Q000502:physiology*; D007962:Leukocytes / Q000502:physiology*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000502:physiology; D015398:Signal Transduction; D019010:Vascular Cell Adhesion Molecule-1 / Q000502:physiology
D007136:Immunoglobulins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1