[Research progress on basal-like breast cancer].
Breast cancer is the most common cancer in women all around the world. Presently, the prognosis of breast cancer is predicted based on histopathologic tumor characteristics. Molecular markers could help to predict the prognosis and treatment response in breast cancer. According to gene expression profile, invasive breast cancers are classified into four subtypes (luminal A, luminal B, HER2 overexpressing and basal-like) and associated with different prognosis. The basal-like subtype is associated with poor prognosis. This article simply introduced the distribution of molecular subtypes, summed up recent researches on the characteristics and prognosis of basal-like phenotype.
Chen
Li-Ying
LY
Department of Breast Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People's Republic of China.
Chen
Hong-Feng
HF
D001943:Breast Neoplasms / Q000145:classification / Q000188:drug therapy / Q000378:metabolism*; D002280:Basal Cell Carcinoma / Q000188:drug therapy / Q000378:metabolism*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy / Q000378:metabolism*; D051242:Caveolin 1 / Q000378:metabolism; D005260:Female; D006801:Humans; D053537:Keratin-17 / Q000378:metabolism*; D053555:Keratin-5 / Q000378:metabolism*; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
D051242:Caveolin 1; D053537:Keratin-17; D053555:Keratin-5; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human