title: Inhibition of Immune Complex-Induced Inflammation by A small Molecular Weight Selectin Antagonist.
abstract: The anti-inflammatory effect of a small molecular weight antagonist of P- and E-selectin-dependent cell adhesion was examined. The glycolipid sulphatide was shown to block the adherence of thrombin-activated rat platelets to HL-60 cells. This interaction is known to be dependent on P-selectin. The rat dermal reverse passive Arthus reaction was used to assess the effect of sulphatide on a neutrophil dependent inflammatory response. Sulphatide dosedependently blocked both the vascular permeability increase and cell infiltration after intraperitoneal administration. These results show that a small molecular weight compound which blocks P- and E-selectin dependent adhesion in vitro can effectively block the inflammation due to immune complex deposition. A compound with this type of profile may have therapeutic potential in the treatment of immune complex mediated diseases.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute 100 Forest Avenue Buffalo NY 14213 USA.
authors.forename: X
authors.initials: X
authors.lastname: Nair
authors.forename: G
authors.initials: G
authors.lastname: Todderud
authors.forename: L
authors.initials: L
authors.lastname: Davern
authors.forename: D
authors.initials: D
authors.lastname: Lee
authors.forename: A
authors.initials: A
authors.lastname: Aruffo
authors.forename: K M
authors.initials: KM
authors.lastname: Tramposch