title: Influence of resection volume on locoregional recurrence of breast cancer after breast-conserving surgery.
abstract: BACKGROUND
  The goals of breast-conserving surgery are to provide the survival equivalent of mastectomy, a cosmetically acceptable breast and a low rate of locoregional recurrence in the treated breast. This retrospective study investigated the impact of the resection volume on locoregional recurrence after breast-conserving therapy in patients with early-stage invasive breast cancer.
  
  
  METHODS
  Retrospective data from 185 women who were treated for operable breast tumours by breast-conserving surgery between 1995-1999 at the Martin-Luther-University in Halle/Germany were included in our study. Extent of total resection volume (TRV), tumour volume (V) and difference volume (DV) was compared for the influence on locoregional recurrence.
  
  
  RESULTS
  Our data showed no significant correlation between the risk of locoregional recurrence and the extent of resection volume. Predictors of an increased risk of locoregional recurrence after breast-conserving surgery were large primary tumour, grading, lymphatic vascular invasion, hormone receptor status and lack of radiotherapy or hormonal therapy.
  
  
  CONCLUSIONS
  According to the accuracy of locoregional disease control and maintenance of the breast's shape, our results support conservative surgery in early-stage breast cancer followed by radiotherapy and adjuvant systemic therapy.
authors.affiliation: Department of Obstetrics and Gynecology, Johannes Gutenberg University Mainz, Mainz, Germany. dboehm@uni-mainz.de
authors.forename: Daniel Ulrich
authors.initials: DU
authors.lastname: Boehm
authors.forename: Antje
authors.initials: A
authors.lastname: Lebrecht
authors.forename: Theodoros
authors.initials: T
authors.lastname: Maltaris
authors.forename: Marcus
authors.initials: M
authors.lastname: Schmidt
authors.forename: Wulf
authors.initials: W
authors.lastname: Siggelkow
authors.forename: Susanne
authors.initials: S
authors.lastname: Fischer
authors.forename: Eva
authors.initials: E
authors.lastname: Kandelhart
authors.forename: Heinz
authors.initials: H
authors.lastname: Koelbl
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental / Q000379:methods; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies