title: pFlexAna: detecting conformational changes in remotely related proteins.
abstract: The pFlexAna (protein flexibility analyzer) web server detects and displays conformational changes in remotely related proteins, without relying on sequence homology. To do so, it first applies a reliable statistical test to align core protein fragments that are structurally similar and then clusters these aligned fragment pairs into 'super-alignments', according to the similarity of geometric transformations that align them. The result is that the dominant conformational changes occur between the clusters, while the smaller conformational changes occur within a cluster. pFlexAna is available at http://bigbird.comp.nus.edu.sg/pfa2/.
authors.affiliation: Department of Computer Science, National University of Singapore, Singapore 117590, Singapore-MIT Alliance, Singapore.
authors.forename: Anshul
authors.initials: A
authors.lastname: Nigham
authors.forename: Lisa
authors.initials: L
authors.lastname: Tucker-Kellogg
authors.forename: Ivana
authors.initials: I
authors.lastname: Mihalek
authors.forename: Chandra
authors.initials: C
authors.lastname: Verma
authors.forename: David
authors.initials: D
authors.lastname: Hsu
mesh_terms: D020407:Internet; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D012984:Software; D040681:Structural Homology, Protein; D000637:Transaminases / Q000737:chemistry; D044767:Ubiquitin-Protein Ligases / Q000737:chemistry; D014584:User-Computer Interface
chemical_list: D044767:Ubiquitin-Protein Ligases; D000637:Transaminases; C020656:glutamine-pyruvate aminotransferase