Dopaminergic modulation of emotional memory in Parkinson's disease.
The aim of this study was to assess the effect of dopaminergic treatment on emotional memory in patients with Parkinson's disease (PD). We tested memory for emotional and neutral visual stimuli in ten non-demented PD patients on and off dopaminergic medication. Patients recalled significantly more emotional items during the off- than on-medication testing session. In contrast, treatment condition did not affect memory for neutral items. These findings demonstrate that emotional memory deficits observed in PD may result from dopaminergic treatment and suggest an involvement of dopaminergic neurotransmission in emotional processing.
Hälbig
Thomas D
TD
Department of Neurology, Charité, Universitätsmedizin Berlin, Campus Virchow Klinikum, 13353, Berlin, Germany. thomas.halbig@psl.aphp.fr
Kopp
Ute A
UA
Wodarz
Franziska
F
Borod
Joan C
JC
Gracies
Jean-Michel
JM
Ebersbach
Georg
G
Kupsch
Andreas
A
D000368:Aged; D000978:Antiparkinson Agents / Q000494:pharmacology / Q000627:therapeutic use; D004298:Dopamine / Q000502:physiology*; D015259:Dopamine Agents / Q000494:pharmacology / Q000627:therapeutic use; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000523:psychology*; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
D000978:Antiparkinson Agents; D015259:Dopamine Agents; D004298:Dopamine