Phased array 3D MR spectroscopic imaging of the brain at 7 T.
Ultra-high-field 7 T magnetic resonance (MR) scanners offer the potential for greatly improved MR spectroscopic imaging due to increased sensitivity and spectral resolution. Prior 7 T human single-voxel MR Spectroscopy (MRS) studies have shown significant increases in signal-to-noise ratio (SNR) and spectral resolution as compared to lower magnetic fields but have not demonstrated the increase in spatial resolution and multivoxel coverage possible with 7 T MR spectroscopic imaging. The goal of this study was to develop specialized radiofrequency (RF) pulses and sequences for three-dimensional (3D) MR spectroscopic imaging (MRSI) at 7 T to address the challenges of increased chemical shift misregistration, B1 power limitations, and increased spectral bandwidth. The new 7 T MRSI sequence was tested in volunteer studies and demonstrated the feasibility of obtaining high-SNR phased-array 3D MRSI from the human brain.
Xu
Duan
D
Joint UCSF/UC Berkeley Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA 94143, USA. duan@mrsc.ucsf.edu
Cunningham
Charles H
CH
Chen
Albert P
AP
Li
Yan
Y
Kelley
Douglas A C
DA
Mukherjee
Pratik
P
Pauly
John M
JM
Nelson
Sarah J
SJ
Vigneron
Daniel B
DB
D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity