title: Antioxidant properties of oxime 3-(phenylhydrazono) butan-2-one.
abstract: Oximes are a class of compounds normally used to reverse the acetylcholinesterase (AChE) inhibition caused by organophosphates (OPs). Conversely, researches focusing on the possible antioxidant properties of these compounds are lacking in the literature. The aim of this study was to investigate the potential antioxidant and toxic properties of 3-(phenylhydrazono) butan-2-one oxime in mice. In vitro, hydrogen peroxide-induced lipid peroxidation was decreased by low concentrations of the oxime (0.1-1.0 microM); (P < 0.05). Similarly, lipoperoxidation induced by malonate and iron (Fe2+) was significantly decreased by the oxime (0.4-1.0 microM) (P < 0.05). Oxime pre-treatment did not modify the basal peroxidation level nor prevented the induced lipid peroxidation determined ex-vivo. The present results suggest that 3-(phenylhydrazono) butan-2-one oxime could be a good antioxidant compound. The absence of toxicity signs after in vivo administration of 3-(phenylhydrazono) butan-2-one oxime to mice may indicate that it could be a safe drug for further studies.
authors.affiliation: Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus UFSM, Santa Maria, RS 97105-900, Brazil.
authors.forename: Gustavo Orione
authors.initials: GO
authors.lastname: Puntel
authors.forename: Priscila
authors.initials: P
authors.lastname: Gubert
authors.forename: Gisele Louro
authors.initials: GL
authors.lastname: Peres
authors.forename: Leandro
authors.initials: L
authors.lastname: Bresolin
authors.forename: João Batista Teixeira
authors.initials: JB
authors.lastname: Rocha
authors.forename: Maria Ester
authors.initials: ME
authors.lastname: Pereira
authors.forename: Vanessa Santana
authors.initials: VS
authors.lastname: Carratu
authors.forename: Félix A Antunes
authors.initials: FA
authors.lastname: Soares
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000633:toxicity; D001713:Biphenyl Compounds; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D003855:Deoxyribose / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D007502:Iron Chelating Agents / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008314:Malonates / Q000378:metabolism; D051379:Mice; D010091:Oximes / Q000494:pharmacology* / Q000633:toxicity; D010851:Picrates / Q000737:chemistry; D000623:Porphobilinogen Synthase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: C533883:3-(phenylhydrazono) butan-2-one oxime; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D007502:Iron Chelating Agents; D008314:Malonates; D010091:Oximes; D010851:Picrates; D017392:Thiobarbituric Acid Reactive Substances; D003855:Deoxyribose; C030290:malonic acid; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl; D007501:Iron; D000623:Porphobilinogen Synthase