Recent advances in reproductive neuroendocrinology: a role for RFamide peptides in seasonal reproduction?
Most temperate-zone species use photoperiod to coordinate breeding and ensure that offspring are born during favourable conditions. Although photoperiodic influences on the reproductive axis have been well characterized, the precise mechanisms by which photoperiodic information and other seasonal cues are integrated to regulate reproductive function remain less well specified. Two recently discovered neuropeptides, kisspeptin and gonadotropin-inhibitory hormone, have pronounced opposing influences on reproductive function. This paper will review recent evidence for a role of these peptides in seasonal reproduction and propose a theoretical framework by which these novel regulatory peptides may serve to regulate seasonal breeding. Understanding the mechanisms regulating appropriate changes in reproductive status will serve to advance a wide range of life science disciplines.
Greives
Timothy J
TJ
Department of Biology, Center for the Integrative Study of Animal Behavior and Program in Neuroscience, Indiana University, Bloomington, IN 47405, USA. tjgreive@indiana.edu
Kriegsfeld
Lance J
LJ
Bentley
George E
GE
Tsutsui
Kazuyoshi
K
Demas
Gregory E
GE
D000818:Animals; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology*; D017440:Photoperiod; D010913:Pituitary-Adrenal System / Q000502:physiology*; D012098:Reproduction / Q000502:physiology*; D012621:Seasons
D009479:Neuropeptides; C416987:RFamide peptide