[Tissue-specific features of the pentose phosphate pathway in rats under acute alcoholic intoxication conditions].
The activity of pentose phosphate pathway (PPP) in the liver and skeletal muscles of rats has been studied after acute alcohol administration in a dose of 1, 2.5, and 5 g/kg body weight. Inhibition of the activity of the main PPP enzymes as well as a decrease in the liver pentose level in rats as a result of alcohol intoxication have been observed. In muscle tissues, alcohol leads to the activation of glucose-6-phosphate-dehydrogenase and the inhibition of the transketolase activity.
Lelevich
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SV
D000435:Alcoholic Intoxication / Q000201:enzymology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004789:Enzyme Activation; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008099:Liver / Q000201:enzymology*; D008297:Male; D018482:Muscle, Skeletal / Q000201:enzymology*; D009928:Organ Specificity; D010427:Pentose Phosphate Pathway; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D005954:Glucosephosphate Dehydrogenase