Alpha,alpha-diarylprolinol ethers: new tools for functionalization of carbonyl compounds.
Alpha,alpha-diaryl(dialkyl)prolinol ethers constitute a potent organocatalyst family which has been shown to be very general for a broad range of reactions involving enamine and iminium ion activation or a combination of both. The reactions are characterized by an efficient steric control approach and can lead to a variety of alpha-, beta-, gamma-, and alpha,beta-functionalized carbonyl compounds with excellent stereocontrol. As a full expression of their catalytic activity, these compounds are also excellent promoters of elegant cascade processes and valuable catalysts in water-compatible systems.
Mielgo
Antonia
A
Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo, 1072. 20080 San Sebastián, Spain.
Palomo
Claudio
C
D000447:Aldehydes / Q000737:chemistry; D002255:Carbonic Acid / Q000737:chemistry*; D002384:Catalysis; D004986:Ether / Q000737:chemistry*; D007097:Imines / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000447:Aldehydes; D007097:Imines; D014867:Water; D004986:Ether; D002255:Carbonic Acid