title: Management of unresectable stage III non-small-cell lung cancer with combined-modality therapy: a review of the current literature and recommendations for treatment.
abstract: Lung cancer remains the most common cause of cancer deaths in the United Kingdom, and long-term survival from lung cancer has hardly improved over the past 30 years. The benefit of combined-modality therapy with chemotherapy and radiation therapy in improving survival for patients with inoperable non-small-cell lung cancer (NSCLC) was discovered over 10 years ago. In this comprehensive literature review, we discuss the current status of combined-modality therapy for unresectable stage III NSCLC. The efficacy and toxicity of different chemoradiation therapy regimens are presented. The potential role of novel and targeted therapies and radiation dose escalation is also considered. Finally, recommendations are made for the treatment of unresectable stage III NSCLC.
authors.affiliation: Department of Clinical Oncology, Christie Hospital, Manchester, UK. neil.bayman@christie.nhs.uk
authors.forename: Neil A
authors.initials: NA
authors.lastname: Bayman
authors.forename: Fiona
authors.initials: F
authors.lastname: Blackhall
authors.forename: Pooja
authors.initials: P
authors.lastname: Jain
authors.forename: Lip
authors.initials: L
authors.lastname: Lee
authors.forename: Nick
authors.initials: N
authors.lastname: Thatcher
authors.forename: Corinne
authors.initials: C
authors.lastname: Faivre-Finn
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000628:therapy*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D011878:Radiotherapy