title: Baker's yeast-mediated synthesis of endo-2-cineolylol, a starting compound for potential cosmetic odourants.
abstract: Baker's yeast-mediated reduction of (+)-1,3,3-trimethyl-2-oxabicyclo[2,2,2]octan-6-one yields the corresponding 1,3,3-trimethyl-2-oxabicyclo[2,2,2]octan-6-ol as endo configuration in optically pure form. To study the reaction behaviour we have developed a RP-HPLC method. The synthesis and the olfactive character of some esters obtained from the endo-2-cineolylol are reported. A comparative odour evaluation between these esters and the corresponding compounds synthesized from the endo-exo alcohol mixture was performed.
authors.affiliation: Dipartimento Scienze Farmaceutiche dell’Università, Viale Benedetto XV 3, 16132 Genova I, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Mariani
authors.forename: M
authors.initials: M
authors.lastname: Bruno
authors.forename: C
authors.initials: C
authors.lastname: Villa
authors.forename: C
authors.initials: C
authors.lastname: Neuhoff