[Severe lactic acidosis caused by propofol infusion: report of one case].
Propofol infusion syndrome (PRIS) is a rare but potentially lethal complications. This disorder is triggered under unknown circumstances by a propofol infusion of more than 5 mg/kg/h for more than 48 h. PRIS is characterized by a multiorgan failure and rhabdomyolysis and is induced by a disturbance in mitochondrial long chain fatty acid oxidation. We report a 43 year-old woman who underwent brain surgery due to a vascular malformation. In the immediate postoperative period, she had an unexplained and severe lactic acidosis. During anaesthesia, she received a propofol infusion of 7 mg/kg/h that continued in the UCI at a rate of 3.5 mg/kg/h, for 8 hours more. The suspicion of PRIS motivated immediate discontinuation of propofol with rapid correction of lactic acidosis and full recovery of the patient.
Romero P
Carlos
C
Intensive Care Unit, Hospital Clínico Universidad de Chile, Santiago de Chile. caromero@redclinicauchile.cl
Morales R
Mónica
M
Donaire R
Luisa
L
Llanos V
Osvaldo
O
Cornejo R
Rodrigo
R
Gálvez A
Ricardo
R
Castro O
José
J
D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000175:diagnosis; D000328:Adult; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D007262:Infusions, Intravenous; D007431:Intraoperative Complications / Q000139:chemically induced; D015742:Propofol / Q000009:adverse effects*; D013997:Time Factors
D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D015742:Propofol