title: An association between invasive breast cancer and familial idiopathic hyperparathyroidism: a case series and review of the literature.
abstract: The possibility of an association between primary hyperparathyroidism and breast cancer has been postulated. We report here a sibship with three premenopausal breast cancers and hyperparathyroidism, and no detectable BRCA or MEN1 gene mutations. We explore genetic and molecular rationales for an association between these metabolic and neoplastic processes.
authors.affiliation: Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
authors.forename: Sumanta Kumar
authors.initials: SK
authors.lastname: Pal
authors.forename: Kathleen
authors.initials: K
authors.lastname: Blazer
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Weitzel
authors.forename: George
authors.initials: G
authors.lastname: Somlo
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D005192:Family Health; D005260:Female; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000235:genetics; D009154:Mutation; D009361:Neoplasm Invasiveness; D010375:Pedigree; D011518:Proto-Oncogene Proteins / Q000235:genetics
chemical_list: C105373:MEN1 protein, human; D011518:Proto-Oncogene Proteins