[Search for chaperon-like anticataract agents, the antiaggregants of lens crystallin. Communication 3. Possibilities of a follow-up of caractogenesis processes on a prolonged rat model of UV-induced cataract].
To study the mechanisms of action of new-generation anticataract drugs, it is necessary to have an accessible and adequate model of age-related cataract. A model of UV-induced cataract is pathogenetically closest to that of age-related cataract. A prolonged rat model of UV-induced cataract developing within 10 months is proposed; the clinical features of UV-induced cataract have been established at different stages of its development. A moderate homogeneous cloud-like lenticular opacity was observed at the end of the experiment; a less pronounced homogeneous opacity was seen in the anterior and posterior cortical layers. Cataract development was assessed by the appraisal method using the developed rat lenticular transparency scale, as well as by microdensitometry of biomicroscopic lenticular optical sections. Within the proposed model, the pathomorphological lenticular changes are largely similar to the histological pattern of age-related cataract.
Avetisov
S E
SE
Polunin
G S
GS
Sheremet
N L
NL
Muranov
K O
KO
Makarov
I A
IA
Fedorov
A A
AA
Karpova
O E
OE
Ostrovskiĭ
M A
MA
D000818:Animals; D002386:Cataract / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D003459:Crystallins / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D004195:Disease Models, Animal; D018450:Disease Progression; D005500:Follow-Up Studies; D007908:Lens, Crystalline / Q000378:metabolism* / Q000473:pathology / Q000528:radiation effects; D008297:Male; D018832:Molecular Chaperones / Q000627:therapeutic use*; D011379:Prognosis; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects
D003459:Crystallins; D018832:Molecular Chaperones