title: Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels.
abstract: The effect of vaccination with diphtheria toxoid (AD-M) on TNF and IL-6 production has been studied in humans. In the present study it was demonstrated that immunization with AD-M resulted in changes of in vitro TNF and IL-6 production by peripheral blood mononuclear cells. TNF release was suppressed but IL-6 production was stimulated. On the other hand, serum levels of TNF were markedly increased over a period of 3 weeks. It was also demonstrated that the postvaccinal cytokine production disturbances may be corrected by pretreatment with a new synthetic hexapeptid (Imunofan((R))). It is possible that the imunofan treatment could prevent some postvaccinal complications.
authors.affiliation: Research Centre for Medical Genetics 1 Moskvorechie Street Moscow 115478 Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Pukhalsky
authors.forename: M S
authors.initials: MS
authors.lastname: Bliacher
authors.forename: A V
authors.initials: AV
authors.lastname: Danilina
authors.forename: E A
authors.initials: EA
authors.lastname: Kalashnikova
authors.forename: T K
authors.initials: TK
authors.lastname: Lopatina
authors.forename: I M
authors.initials: IM
authors.lastname: Fedorova