title: Mastoid obliteration using calcium phosphate bone paste with an artificial dermis soaked with basic fibroblast growth factor: preliminary clinical report.
abstract: OBJECTIVE
  To describe mastoid obliteration using a calcium phosphate paste with an artificial dermis soaked with basic fibroblast growth factor (b-FGF) and the usefulness of this procedure.
  
  
  METHODS
  Ten ears that underwent a canal wall-down mastoidectomy were treated with calcium phosphate paste. The cases consisted of four patients with mastoid cavity problem, four with middle ear cholesteatoma, one with adhesive otitis media, and one with external auditory canal cholesteatoma. The post-operative follow-up period was 19.9 months on average (ranging from 13 to 23 months). First, the canal wall-down mastoidectomy was performed. Then, the calcium phosphate paste was used to fill up to the facial ridge posteriorly and the horizontal segment of the facial canal superiorly. The surface of the paste was covered with an artificial dermis soaked with b-FGF.
  
  
  RESULTS
  Following calcium phosphate paste treatment, all open cavities were decreased in volume and epithelized within 2 months.
  
  
  CONCLUSIONS
  Calcium phosphate paste appears effective for mastoid obliteration. Using an artificial dermis soaked with b-FGF appears to prevent exposure of the paste to the skin of the external auditory meatus. However, the number of the patients is too small to draw any conclusion.
authors.affiliation: Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi 783-8505, Japan. kakigia@kochi-u.ac.jp
authors.forename: Akinobu
authors.initials: A
authors.lastname: Kakigi
authors.forename: Daizo
authors.initials: D
authors.lastname: Taguchi
authors.forename: Taizo
authors.initials: T
authors.lastname: Takeda
mesh_terms: D000328:Adult; D000368:Aged; D002130:Calcium Phosphates / Q000008:administration & dosage*; D002781:Cholesteatoma / Q000601:surgery; D004424:Ear Canal / Q000601:surgery; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008416:Mastoid / Q000601:surgery*; D010033:Otitis Media / Q000601:surgery; D017768:Skin, Artificial; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D002130:Calcium Phosphates; D016222:Fibroblast Growth Factor 2; C020243:calcium phosphate