Synthesis of carbohydrate-conjugated nanoparticles and quantum dots.
Nanoparticle-based probes are emerging as alternatives to molecular probes due to their various advantages, such as bright and tunable optical property, enhanced chemical and photochemical stability, and ease of introduction of multifunctionality. This work presents a simple and general approach for functionalizing various nanoparticle systems for use as glycobiological probes. Silica-coated nanoparticles of Ag, Fe3O4, and ZnS-CdSe were synthesized and functionalized with dextran. The resulting 10-40-nm-sized particles were robust, water-soluble, colloidally stable, and biochemically active.
Earhart
Christopher
C
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.
Jana
Nikhil R
NR
Erathodiyil
Nandanan
N
Ying
Jackie Y
JY
D019187:Cadmium Compounds / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D003102:Colloids / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry; D004867:Equipment Design; D005290:Ferric Compounds / Q000737:chemistry; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010777:Photochemistry / Q000379:methods; D045663:Quantum Dots; D018036:Selenium Compounds / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D012834:Silver / Q000737:chemistry; D013440:Sulfides / Q000737:chemistry; D013499:Surface Properties; D017967:Zinc Compounds / Q000737:chemistry
D019187:Cadmium Compounds; D002241:Carbohydrates; D003102:Colloids; D003911:Dextrans; D005290:Ferric Compounds; D018036:Selenium Compounds; D013440:Sulfides; D017967:Zinc Compounds; C000499:ferric oxide; D012834:Silver; D012822:Silicon Dioxide; C058667:cadmium selenide; C031238:zinc sulfide