Fast stereoselective reactions in electrosprayed Co(II)/neurotransmitter nanodroplets.
Collision induced dissociation (CID) of the m/z 479 ion, formed by ESI of Co(NO3)2-CH3OH solutions with either pure (1S,2S)-(+)-N-methylpseudoephedrine or its mixtures with (1S,2R)-(+)- or (1R,2S)-(-)-ephedrine, provides compelling evidence for fast, stereoselective reactions in Co(II)/neurotrasmitter(s) aggregates during solvent evaporation of the ESI droplets.
Fraschetti
Caterina
C
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università di Roma La Sapienza, Rome, Italy.
Aschi
Massimiliano
M
Filippi
Antonello
A
Giardini
Anna
A
Speranza
Maurizio
M
D003035:Cobalt / Q000737:chemistry*; D004809:Ephedrine / Q000031:analogs & derivatives / Q000737:chemistry; D000432:Methanol / Q000737:chemistry; D008956:Models, Chemical; D018377:Neurotransmitter Agents / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
D018377:Neurotransmitter Agents; D003035:Cobalt; C041707:N-methylephedrine; C025913:cobaltous nitrate; D004809:Ephedrine; D000432:Methanol