title: Accidental introduction of viruses into companion animals by commercial vaccines.
abstract: The use of biologics in veterinary medicine has been of tremendous value in safeguarding our animal populations from debilitating and oftentimes fatal disease. This article reviews the principles of vaccination and the extensive quality control efforts that are incorporated into preparing the vaccines. Examples of adverse events that have occurred in the past and how enhanced vigilance at the level of the veterinarian and the veterinary diagnostic laboratory help to curtail these events are discussed. Emphasis on understanding the ecology of viral infections in dogs and cats is introduced, together with the concepts of the potential role of vaccines in interspecies spread of viruses.
authors.affiliation: Department of Veterinary Clinical Sciences, Washington Animal Disease Diagnostic Laboratory, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA. jfe@vetmed.wsu.edu
authors.forename: James F
authors.initials: JF
authors.lastname: Evermann
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000517:prevention & control* / Q000635:transmission / Q000821:virology; D002415:Cats; D004283:Dog Diseases / Q000517:prevention & control* / Q000635:transmission / Q000821:virology; D004285:Dogs; D011786:Quality Control; D013045:Species Specificity; D014481:United States; D014611:Vaccination / Q000009:adverse effects / Q000662:veterinary*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D014777:Virus Diseases / Q000517:prevention & control / Q000635:transmission / Q000662:veterinary* / Q000821:virology
chemical_list: D014765:Viral Vaccines