title: Apnea and its possible relationship to immunization in ex-premature infants.
abstract: This study compared the characteristics of infants hospitalized with apnea that participated in a vaccine trial compared with two control groups which consisted of 100 infants randomly selected from the same vaccine trial and 52 consecutively born very low birth weight (VLBW) infants. A total of 23 infants were admitted with apnea of whom 19 weighed <1500 g at birth and all were born at <37 weeks gestation. More of the VLBW infants in the apnea group had neonatal neurological complications compared with the VLBW control group (p=0.005). Ten of 11 children with apnea within 72 h of immunization were possibly related to vaccination.
authors.affiliation: Department of Paediatrics, University of the Witwatersrand, South Africa.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Cooper
authors.forename: Shabir A
authors.initials: SA
authors.lastname: Madhi
authors.forename: Robin E
authors.initials: RE
authors.lastname: Huebner
authors.forename: Nontombi
authors.initials: N
authors.lastname: Mbelle
authors.forename: Salim S Abdool
authors.initials: SS
authors.lastname: Karim
authors.forename: Immo
authors.initials: I
authors.lastname: Kleinschmidt
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Forrest
authors.forename: Keith P
authors.initials: KP
authors.lastname: Klugman
mesh_terms: D001049:Apnea / Q000209:etiology*; D016022:Case-Control Studies; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D022242:Pneumococcal Vaccines / Q000009:adverse effects*
chemical_list: D022242:Pneumococcal Vaccines