title: Comparison of metoclopramide oral tablets and solution in treatment of dysmotility-like dyspepsia.
abstract: OBJECTIVE
  The clinical effects of metoclopramide oral solution and tablets in patients with dysmotility-like dyspepsia (DLD) were compared.
  
  
  METHODS
  In a prospective study, 63 patients with DLD, selected according to Rome II criteria and randomly divided into three groups, received metoclopramide tablets 5 mg t.i.d., metoclopramide oral solution 2 mg t.i.d., or placebo for one week. Assessment was based on symptom score determined by interviews and on gastric emptying time measured by ultrasonography before and after drug consumption. Two antral and stomach body biopsies were taken to evaluate infection with Helicobacter pylori and the intensity of gastritis.
  
  
  RESULTS
  Symptom score and gastric emptying time were significantly reduced in both metoclopramide groups (p < 0.05) but not in the control group. Patients receiving the oral solution had a greater reduction in the symptom score than those receiving tablets (p < 0.05). The absence or presence of and intensity of gastritis or H. pylori infection had no correlation with the symptom scores or gastric emptying times.
  
  
  CONCLUSIONS
  Metoclopramide oral solution 2 mg t.i.d. was at least as effective as metoclopramide tablets 5 mg t.i.d. in reducing symptoms of DLD and gastric emptying time.
authors.affiliation: Department of Internal Medicine, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. sjbanani@yahoo.com
authors.forename: S Javad
authors.initials: SJ
authors.lastname: Banani
authors.forename: Kamran B
authors.initials: KB
authors.lastname: Lankarani
authors.forename: Alireza
authors.initials: A
authors.lastname: Taghavi
authors.forename: Mohammad Hadi
authors.initials: MH
authors.lastname: Bagheri
authors.forename: Sepideh
authors.initials: S
authors.lastname: Sefidbakht
authors.forename: Bita
authors.initials: B
authors.lastname: Geramizadeh
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004415:Dyspepsia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005746:Gastric Emptying; D005765:Gastrointestinal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage* / Q000627:therapeutic use; D011446:Prospective Studies; D012996:Solutions; D013607:Tablets; D014463:Ultrasonography
chemical_list: D005765:Gastrointestinal Agents; D012996:Solutions; D013607:Tablets; D008787:Metoclopramide