title: A comparison of biological activities of a new soya biopeptide studied in an in vitro skin equivalent model and human volunteers.
abstract: During aging, the epidermis and dermis become thin and an efficient anti-aging product should be able to stimulate the metabolism of senescent fibroblast and keratinocytes, in order to increase the quantity of extra-cellular matrix components such as collagen and glycosaminoglycans. A study performed in parallel on an in vitro skin equivalent model, and in vivo, with human volunteers, demonstrated the efficacy of one specific soya biopeptide for anti-aging properties. Such a biopeptide induces a significant increase of glycosaminoglycans synthesis in vitro and in vivo after a one-month treatment. We also showed that this new cosmetic ingredient is able to stimulate favourably the collagen synthesis in vitro and in vivo. This study provided the proof for anti-aging properties of a new soya biopeptide and also validated the skin equivalent model developed for this experimentation as an alternative method to animal or human testing for some cosmetic efficacy evaluations.
authors.affiliation: Henkel KGaA Henkelstrasse 67, POB 1100, 40191 Düsseldorf, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Andre-Frei
authors.forename: E
authors.initials: E
authors.lastname: Perrier
authors.forename: C
authors.initials: C
authors.lastname: Augustin
authors.forename: O
authors.initials: O
authors.lastname: Damour
authors.forename: P
authors.initials: P
authors.lastname: Bordat
authors.forename: K
authors.initials: K
authors.lastname: Schumann
authors.forename: T
authors.initials: T
authors.lastname: Förster
authors.forename: M
authors.initials: M
authors.lastname: Waldmann-Laue