A prospective comparison of random urine protein-creatinine ratio vs 24-hour urine protein in women with preeclampsia.
OBJECTIVE
To assess the diagnostic accuracy of random urine protein-creatinine ratio for the prediction of significant proteinuria in patients with preeclampsia.


METHODS
155 pregnant patients diagnosed to have hypertension in late pregnancy were instructed to collect urine during a 24-hour period. Protein-creatinine ratio was evaluated in a random urinary specimen. Out of these, 120 patients fulfilled the inclusion criteria. The predictive value of the random urinary protein-creatinine ratio for the diagnosis of significant proteinuria was estimated by using a 300-mg protein level within the collected 24-hour urine as the gold standard.


RESULTS
104 patients (86.67%) had significant proteinuria. There was significant association between 24-hour protein excretion and the random urine protein-creatinine ratio (r(s)=0.596, P < .01). With a cut-off protein-creatinine ratio greater than 1.14 as a predictor of significant proteinuria, sensitivity and specificity were 72% and 75%, respectively. The positive predictive value was 94.9% and negative predictive value was 29.2%.


CONCLUSIONS
The random urine protein-creatinine ratio was not a good predictor of significant proteinuria in patients with preeclampsia.
Aggarwal
N
N
Department of Obstetrics & Gynecology, PGIMER, Chandigarh, India.
Suri
V
V
Soni
S
S
Chopra
V
V
Kohli
H S
HS
D000328:Adult; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000652:urine*; D011247:Pregnancy; D011446:Prospective Studies; D011507:Proteinuria / Q000175:diagnosis* / Q000652:urine*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016482:Urinalysis / Q000379:methods*
D003404:Creatinine