title: An efficient strategy for the synthesis of endocyclic enol ethers and its application to the synthesis of spiroacetals.
abstract: An efficient strategy for the synthesis of endocyclic enol ethers based on a Suzuki-Miyaura coupling/ring-closing metathesis sequence has been developed. The strategy has successfully been applied to the synthesis of spiroacetals, including cytotoxic marine metabolites attenols A and B.
authors.affiliation: Laboratory of Biostructural Chemistry, Graduate School of Life Sciences, Tohoku University, Sendai, Japan. hfuwa@bios.tohoku.ac.jp
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Fuwa
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000080:Acetals / Q000138:chemical synthesis*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D049872:Bivalvia / Q000737:chemistry; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000080:Acetals; D000970:Antineoplastic Agents; D004988:Ethers, Cyclic; D013141:Spiro Compounds; C423354:attenol A