Time and frequency characteristics of Purkinje cell complex spikes in the awake monkey performing a nonperiodic task.
A number of studies have been interpreted to support the view that the inferior olive climbing fibers send periodic signals to the cerebellum to time and pace behavior. In a direct test of this hypothesis in macaques performing nonperiodic tasks, we analyzed continuous recordings of complex spikes from the lateral cerebellar hemisphere. We found no periodicity outside of a 100-ms relative refractory period.
Hakimian
Shahin
S
Department of Anatomy and Neurobiology, Washington University School of Medicine, Box 8108, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
Norris
Scott A
SA
Greger
Bradley
B
Keating
Jeffrey G
JG
Anderson
Charles H
CH
Thach
W Thomas
WT
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal; D002452:Cell Count / Q000379:methods; D002531:Cerebellum / Q000166:cytology; D005583:Fourier Analysis; D007839:Functional Laterality; D008253:Macaca mulatta; D009412:Nerve Fibers / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology*; D011689:Purkinje Cells / Q000502:physiology*; D013223:Statistics as Topic; D013647:Task Performance and Analysis; D013997:Time Factors; D014851:Wakefulness