[The expressions of TP, MK and CD105 in laryngeal squamous cell carcinoma and their clinical significance].
OBJECTIVE
To explore the expressions of thymidine phosphorylase (TP), midkine (MK) and MVD marked with CD105 antibody in laryngeal squamous cell carcinoma (LSCC) and their clinical significance.


METHODS
The expressions of TP, MK and CD105 in LSCC tissues of 43 cases were studied by immunohistochemical staining.


RESULTS
The positive expression rates of TP and MK in LSCC were 67.4% and 60.5% respectively, the mean value of MVD was 6.01 +/- 1.78. MVD was significantly higher in tumor tissue with both positive TP and MK than in that with both negative TP and MK (7.07 +/- 3.26 vs. 4.03 +/- 1.90, P < 0.05). The expression of TP, MK and CD105 were all correlated with T-stage and lymph node metastasis. Positive TP, MK expression and high MVD were all associated with a poor survival, and positive expression of both TP and MK in tumors conferred a poorer prognosis than negative expression of those factors in tumors, but only the lymph node metastasis and MVD were independent prognostic factors on multivariate analysis.


CONCLUSIONS
Both TP and MK are important for angiogenesis in LSCC. TP, MK and angiogenesis are all closely correlated with the progress of LSCC and the lymph node metastasis. The lymph node metastasis and MVD marked with CD105 antibody were independent prognostic factors. TP and MK may affect the progression and prognosis of tumor by promotion of angiogenesis. A combinative detection of TP, MK and CD105 can be as valuable tumor marker and prognostic factor for LSCC.
Liu
Yuying
Y
Department of Otolaryngology, Kunming General Hospital of Chengdu Command, Kunming, 650032, China.
Xue
Xijun
X
Wang
Fang
F
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D000071063:Endoglin; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D000078792:Midkine; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D009414:Nerve Growth Factors / Q000378:metabolism*; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013939:Thymidine Phosphorylase / Q000378:metabolism*
D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; C066254:MDK protein, human; D009414:Nerve Growth Factors; D011956:Receptors, Cell Surface; D000078792:Midkine; D013939:Thymidine Phosphorylase