Dysregulated RET signaling in thyroid cancer.
Numerous biologic processes and such diseases as cancer depend on activation of tyrosine kinase receptors. The RET tyrosine kinase receptor was discovered two decades ago as a transforming gene and was subsequently implicated in the formation of papillary and medullary thyroid carcinoma. This article examines the data about the mechanism of activation of downstream signal transduction pathways by RET oncoproteins. Collectively, these findings have advanced the understanding of the processes underlying thyroid carcinoma formation.
Castellone
Maria Domenica
MD
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, Università di Napoli Federico II, Naples, Italy.
Santoro
Massimo
M
D018276:Carcinoma, Medullary / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008954:Models, Biological; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000502:physiology; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000235:genetics*
D015514:Oncogene Proteins, Fusion; D051096:Proto-Oncogene Proteins c-ret