title: Mitomycin C in the treatment of gastrointestinal tumours: recent data and perspectives.
abstract: Mitomycin C (MMC) is among the most effective anticancer drugs used for the treatment of a broad variety of tumours. This review summarises results of MMC-based chemotherapy in gastrointestinal tumours with special focus on current treatment options in gastric, pancreatic, biliary tract, colorectal, and anal cancer. In addition, these new developments are critically discussed with special attention to their potential clinical relevance.
authors.affiliation: Onkologisches Zentrum, III. Medizinische Klinik, Medizinische Fakultat Mannheim, Universitat Heidelberg, Germany. ralf.hofheinz@med3.ma.uni-heidelberg.de
authors.forename: Ralf-Dieter
authors.initials: RD
authors.lastname: Hofheinz
authors.forename: Ulrich
authors.initials: U
authors.lastname: Beyer
authors.forename: Salah-Eddin
authors.initials: SE
authors.lastname: Al-Batran
authors.forename: Jörg Thomas
authors.initials: JT
authors.lastname: Hartmann
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D002986:Clinical Trials as Topic / Q000639:trends*; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy*; D006801:Humans; D016685:Mitomycin / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin