title: Polymorphism in methylentetra-hydrofolate reductase gene: important role in diseases.
abstract: It has been recognized that some people have a genetic variant which leads to elevated levels of homocysteine and impairs ability to process folate. This condition was recognized as independent risk factor of coronary heart disease. Recently, connection between this termolabile mutation of the methylenetetrahydrofolate reductase and numerous conditions and diseases has been established. Aim of this review is to draw attention to this interesting area in medicine. Additionally, well defined study about presence and frequency of gene polymorphism in our region will provide proper diagnosis and achieve possible delay of development of diseases with vitamin supplementation.
authors.affiliation: Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Emina
authors.initials: E
authors.lastname: Kiseljaković
authors.forename: Radivoj
authors.initials: R
authors.lastname: Jadrić
authors.forename: Sabaheta
authors.initials: S
authors.lastname: Hasić
authors.forename: Faruk
authors.initials: F
authors.lastname: Skenderi
authors.forename: Halima
authors.initials: H
authors.lastname: Resić
authors.forename: Mira
authors.initials: M
authors.lastname: Winterhalter-Jadrić
mesh_terms: D002318:Cardiovascular Diseases / Q000235:genetics; D003327:Coronary Disease / Q000235:genetics*; D006710:Homocysteine / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007668:Kidney / Q000378:metabolism; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008954:Models, Biological; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics; D019636:Neurodegenerative Diseases / Q000235:genetics; D010597:Pharmacogenetics / Q000379:methods; D011110:Polymorphism, Genetic; D012306:Risk; D012307:Risk Factors
chemical_list: D006710:Homocysteine; D042965:Methylenetetrahydrofolate Reductase (NADPH2)