title: Toxicity profiles in vivo in mice and antitumour activity in tumour-bearing mice of di- and triorganotin compounds.
abstract: The in vivo toxicity profiles in mice and the antitumour activity in tumour bearing mice were screened for four di-n-butyltin and five triorganotin carboxylates, di-n-butyltin diterebate (5), bis(phenylacetate) (6), bis(deoxycholate) (7), bis(lithocholate) (8), tri-n-butyltin terebate (9), cinnamate (10), and triphenyltin terebate (11).At their maximum tolerated dosis (MTD), no antitumour effect (T/C ~1) was observed for the compounds 5, 7, 9, 10 and 11. The compounds 6 (T/C = 0.51) and 8 (T/C = 0.42) showed clear antitumour activity after single dose administration and might therefore be of interest for further antitumour activity studies.
authors.affiliation: Free University of Brussels VUB Faculty of Applied Sciences, Room 8G512 Pleinlaan 2 Brussels B-1050 Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Gielen
authors.forename: R
authors.initials: R
authors.lastname: Willem
authors.forename: H
authors.initials: H
authors.lastname: Dalil
authors.forename: D
authors.initials: D
authors.lastname: de Vos
authors.forename: C M
authors.initials: CM
authors.lastname: Kuiper
authors.forename: G J
authors.initials: GJ
authors.lastname: Peters