title: Comparative Analysis of [Au(en)(2)] and [Pt(en)(2)] non Covalent Binding to Calf Thymus DNA.
abstract: Reactions of the complexes bisethylendiammine gold(III) and bisethylendiammine platinum(II) with calfthymus DNA were comparatively analysed. Both complexes bind DNA non-covalently most probably on the basis of electrostatic interactions. Binding of either complex at low ratios results into modest modifications of B-type DNA conformations, as detected by CD. Far larger CD alterations are observed at high ratios. The gold(III) chromophore is scarcely perturbed by DNA addition Binding of [Au(en)(2)]Cl(3) to calf thymus DNA is reversed by sodium cyanide. By analogy with the case of [Pt(en)(2)]Cl(2) it is suggested that Auen acts as a minor groove binder.
authors.affiliation: CIRCMSB Unit of Florence via Gino Capponi 7 Florence I-50121 Italy.
authors.forename: G
authors.initials: G
authors.lastname: Marcon
authors.forename: T
authors.initials: T
authors.lastname: O'Connell
authors.forename: P
authors.initials: P
authors.lastname: Orioli
authors.forename: L
authors.initials: L
authors.lastname: Messori