title: Quality of life in bipolar type I disorder and schizophrenia in remission: clinical and neurocognitive correlates.
abstract: This cross-sectional study examined the relationships between clinical and neuropsychological variables and self-reported quality of life (QoL) in 30 euthymic bipolar I patients, 23 remitted schizophrenic patients, and 23 healthy controls. Participants were administered the World Health Organization Quality of Life Measure-Abbreviated Version (WHOQOL-BREF) to assess QoL. Moreover, a broad neuropsychological battery was also administered. Bipolar disorder (BD) and schizophrenia patients demonstrated significantly lower scores on the physical, psychological, and social domains of the WHOQOL-BREF compared with controls, but there were no significant differences between the two patient groups on those domains. More symptomatic BD patients reported worse QoL, especially in the physical and environmental domains, which was also associated with worse neurocognitive performance. In schizophrenic patients, neurocognitive performance was not associated with self-reported QoL, but more symptomatic patients reported lower QoL. Substantial impairments in QoL, similar in severity, were found in both patient groups. In patients with schizophrenia, QoL was more strongly related to levels of psychopathology, whereas in BD patients, both psychopathology and neurocognitive deficits were strongly associated with lower QoL. Clinical recovery is essential in schizophrenia and BD. The association between cognitive functioning and QoL in bipolar patients suggests that these patients may also benefit from psychological interventions addressed to improve cognitive deficits and enhance the functional recovery.
authors.affiliation: Júlio de Matos' Psychiatric Hospital, Lisbon, Portugal. sofiabrissos@netcabo.pt
authors.forename: Sofia
authors.initials: S
authors.lastname: Brissos
authors.forename: Vasco Videira
authors.initials: VV
authors.lastname: Dias
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Carita
authors.forename: Anabel
authors.initials: A
authors.lastname: Martinez-Arán
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D035061:Control Groups; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010555:Personality Inventory / Q000706:statistics & numerical data; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011594:Psychometrics; D011788:Quality of Life; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D012944:Social Support; D011795:Surveys and Questionnaires