Adhesion of sickle red cells to endothelium: myths and future directions.
Sickle RBC are abnormally adherent to vascular endothelial cells. We briefly review the mechanisms that underlie this type of cell/cell adhesion, expose a number of extant myths about RBC adhesion, and discuss some aspects that need consideration via future experimentation. The relationship of this phenomenon of RBC-endothelial adhesion to the cytoadherence of parasitized sickle RBC is not yet clear.
Hebbel
R P
RP
Department of Medicine, University of Minnesota, MMC 480, 420 Delaware Street S.E., Minneapolis, MN 55455, USA. hebbe001@umn.edu
D000755:Anemia, Sickle Cell / Q000097:blood / Q000503:physiopathology*; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D004912:Erythrocytes / Q000469:parasitology / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D016778:Malaria, Falciparum / Q000097:blood / Q000503:physiopathology; D012212:Rheology