Synthesis, Characterization and Antitumour Activity of Some Butyltin(IV) Cysteaminates and N,N-Dimethylcysteaminates.
The synthesis and characterization of four di- and tri-n-butyltin cysteaminates and N,N-dimethylcysteaminates and three protonated / quaternized derivatives are reported. They all exhibit moderate or high in vitro cytotoxic activity. Six of seven compounds presented in this work are more active than cisplatin, etoposide and 5-fluorouracil, but less active than methotrexate and doxorubicin.
Gielen
M
M
Departement of General and Organic Chemistry AOSC Faculty of Applied Sciences Free University of Brussels VUV Pleinlaan 2 Brussels B-1050 Belgium.
Handlir
K
K
Hollein
M
M
de Vos
D
D