Taste mask, design and evaluation of an oral formulation using ion exchange resin as drug carrier.
The purpose of this research was to mask the bitter taste of Diphenhydramine Hydrochloride (DPH) using cation exchange resins. Indion 234 and Tulsion 343 that contained crosslinked polyacrylic backbone were used. The drug resin complexes (DRC) were prepared by batch process by taking drug: resin ratios 1:1, 1:2, and 1:3. The optimum drug: resin ratio and the time required for maximum complexation was determined. The drug resinates were evaluated for the drug content, taste, micromeritic properties drug release and X-ray diffraction (PXRD). Effervescent and dispersible tablets were developed from optimum drug: resin ratios of 1:2 and 1:1. The formulations were evaluated for uniformity of dispersion, disintegration time, and in vitro dissolution. The X-ray diffraction study confirmed the monomolecularity of entrapped drug in the resin beads. The taste evaluation depicted the successful taste masking of DPH with drug resin complexes. The drug release of 95% in 15 min was observed for effervescent and dispersible tablets.
Bhise
Kiran
K
Pharmaceutics, M.C.E. Society's Allana College of Pharmacy, 2390 B-K.B. Hidayatullah Road, Pune, Maharastra 411001, India. bhisekiran99@yahoo.com
Shaikh
Shafi
S
Bora
Divyakumar
D
D000284:Administration, Oral; D000328:Adult; D002411:Cation Exchange Resins / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004155:Diphenhydramine / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers; D004339:Drug Compounding; D006634:Histamine H1 Antagonists / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D008297:Male; D010470:Perceptual Masking; D033362:Powder Diffraction; D012995:Solubility; D013607:Tablets; D013649:Taste / Q000187:drug effects*; D013678:Technology, Pharmaceutical / Q000379:methods; D014961:X-Ray Diffraction
D002411:Cation Exchange Resins; D004337:Drug Carriers; D006634:Histamine H1 Antagonists; D013607:Tablets; D004155:Diphenhydramine