title: Total synthesis of cytotoxic macrolide amphidinolide B1 and the proposed structure of amphidinolide B2.
abstract: The first enantioselective total syntheses of cytotoxic macrolide amphidinolide B1 and the proposed structure for amphidinolide B2 have been accomplished. Key features of the syntheses include a diastereoselective aldol condensation, a spontaneous Wadsworth-Emmons macrocyclization and a directed epoxidation/elimination sequence.
authors.affiliation: Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, Oregon 97331, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Lu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Rich G
authors.initials: RG
authors.lastname: Carter
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008387:Marine Toxins / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D000097442:Amphidinolides
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D018942:Macrolides; D008387:Marine Toxins; C511225:amphidinolide B1; D000097442:Amphidinolides; C062197:amphidinolide D