[Correlation between power Doppler vascularity index and microvessel density in high-grade gliomas and adjacent edema].
OBJECTIVE
To investigate the correlation between power Doppler vascularity index (PDVI) and microvessel density (MVD) and evaluate the angiogenesis in high-grade gliomas and the adjacent edema in patients with glioma using intraoperative power Doppler ultrasound (PDUS) during gross total resection.


METHODS
In 25 cases of high-grade gliomas undergoing gross total tumor resections, PDUS was performed intraoperatively and the regions of interest within the tumor and the adjacent edema were analyzed with Photoshop software to measure the tumoral and peritumoral blood flow quantified as PDVI. The tumoral and adjacent MVD were determined using immunohistochemical staining for CD34. The correlation between PDVI in the gliomas and the adjacent edema and MVD in the corresponding areas were analyzed using Spearman correlation test.


RESULTS
The measurement of both PVDI and MVD revealed significant difference in vascularity between the gliomas and the adjacent edema (t=0.000, P<0.01), and PDVI was positively correlated to MVD measurement (r=0.7248 in the tumors and r=0.6608 in the adjacent edema).


CONCLUSIONS
The difference in the vascularity between the tumor and adjacent edema allows their distinction by PDUS during operation for high-grade glioma. Intraoperative PDUS provides an accurate and reliable means for measuring vascularity in the glioma and the adjacent edema tissue.
Chen
Yun-hong
YH
Department of Ultrasonography, Southern Medical University, Guangzhou 510282, China. chenyh@fimmu.com
Zhang
Shi-zhong
SZ
Xiao
Sha
S
Ke
Yi-quan
YQ
Xu
Ru-xiang
RX
Tang
Xiao-ming
XM
D000328:Adult; D001929:Brain Edema / Q000000981:diagnostic imaging* / Q000209:etiology; D001932:Brain Neoplasms / Q000098:blood supply / Q000150:complications / Q000000981:diagnostic imaging*; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D005909:Glioblastoma / Q000098:blood supply / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*