title: Multivariate data analyses of persistent organic pollutants in maternal adipose tissue in Singapore.
abstract: Persistent organic pollutants (POPs) were detected in 88 maternal adipose tissue samples collected during year 2004 to 2006, in Singapore. Organochlorine pesticides (OCPs) were the most dominant followed by polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). Multivariate data analyses (MVA) including principal component analysis (PCA), partial least-squares regression (PLSR), and partial least-squares discriminant analysis (PLS-DA) were applied to elucidate the relationship between concentrations of POPs in adipose tissues and donors' characteristics. Food consumption played the most significant role in accounting for levels of POPs in adipose tissue. Fish and poultry consumption was the route of PCBs and PBDEs in mothers in Singapore, while beta-HCH came mainly from vegetables. An age-dependent accumulation of POPs was found for beta-HCH and PCB congeners, and lactation and gestation functioned as a decontamination processes for PCBs in adipose tissue. Gestational diabetes mellitus (GDM) may change the profile of POPs in adipose tissue, probably due to an alteration in lipid metabolism. POPs investigated here may not be the cause of antenatal complication in pregnant women, and baby gender was not related to the pattern of contaminants in maternal adipose tissue.
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576 Singapore. g0402629@nus.edu.sg
authors.forename: Jing
authors.initials: J
authors.lastname: Tan
authors.forename: Qing Qing
authors.initials: QQ
authors.lastname: Li
authors.forename: Annamalai
authors.initials: A
authors.lastname: Loganath
authors.forename: Yap Seng
authors.initials: YS
authors.lastname: Chong
authors.forename: Man
authors.initials: M
authors.lastname: Xiao
authors.forename: Jeffrey Philip
authors.initials: JP
authors.lastname: Obbard
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D000293:Adolescent; D000328:Adult; D004785:Environmental Pollutants / Q000032:analysis*; D005260:Female; D006801:Humans; D015999:Multivariate Analysis; D009930:Organic Chemicals / Q000032:analysis*; D011247:Pregnancy; D012846:Singapore
chemical_list: D004785:Environmental Pollutants; D009930:Organic Chemicals