Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters.
Microsatellite polymorphism in the promoter region of the heme oxygenase-1 (HO-1) gene was analyzed jointly with that of the inducible nitric oxide synthase (iNOS) gene among Japanese subjects (control and gastric cancer patients). A higher promoter activity genotype of the HO-1 gene was associated with increased risk for gastric cancer in women. Gastric cancer risk was notably increased in subjects carrying a higher promoter activity genotype for both HO-1 and iNOS compared to those with a lower promoter activity genotype for both genes. Our data suggest that genetic polymorphisms of HO-1 and iNOS modulate individual susceptibility to gastric cancer risk.
Sawa
Tomohiro
T
International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France. sawat@kumamoto-u.ac.jp
Mounawar
Mounia
M
Tatemichi
Masayuki
M
Gilibert
Isabelle
I
Katoh
Takahiko
T
Ohshima
Hiroshi
H
D000328:Adult; D000368:Aged; D044466:Asian People; D005260:Female; D005838:Genotype; D051547:Heme Oxygenase-1 / Q000235:genetics*; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D052247:Nitric Oxide Synthase Type II / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D013274:Stomach Neoplasms / Q000209:etiology / Q000235:genetics*
D053583:Interleukin-1beta; D052247:Nitric Oxide Synthase Type II; D051547:Heme Oxygenase-1