[Prevalence of thyroid autoimmune disease in patients with systemic lupus erythematosus].
BACKGROUND
Thyroid autoimmune diseases have been associated with a variety of rheumatologic diseases, including systemic lupus erythematosus (SLE).


OBJECTIVE
To estimate the prevalence of thyroid autoimmune diseases in patients with SLE.


METHODS
Transversal study to compare the prevalence of thyroid disorders in 106 patients with SLE and a control group of 102 patients. The patients were submitted to a clinical and a laboratorial evaluation; the tests included antiperoxidase and antithyroglobulin antibodies, TSH, free T4 and T3.


RESULTS
We detected high prevalence of subclinical hypothyroidism (11%) and clinical hypothyroidism (13%) in the group of patients with SLE when they were compared to the control group, 7% and 1%, respectively (p < 0.001). The hyperthyroidism occurred in a same frequency in the two groups. The positivity of antithyroid antibodies was higher in the group with SLE (23% versus 19%, p = 0.025). The relative risk of the patients with SLE to develop thyroid dysfunctions was 1,6.


CONCLUSIONS
The thyroid disorders were more prevalent in patients with LES than in general population.
Viggiano
Daniela P P Oliveira
DP
Departamento de Clínica Médica, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Universidade Federal de Goiás, Goiânia, GO, Brasil. danippo@ig.com.br
da Silva
Nilzio Antônio
NA
Montandon
Ana C O E Silva
AC
Barbosa
Vitalina de Souza
Vde S
D000328:Adult; D017677:Age Distribution; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000453:epidemiology; D007037:Hypothyroidism / Q000150:complications / Q000453:epidemiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000453:epidemiology*; D055815:Young Adult