title: An enantioselective approach to (+)-laurencin.
abstract: A convergent enantioselective route to an advanced intermediate for the synthesis of the marine natural product (+)-laurencin has been developed. The methodology employs ring-opening of an ephedrine-based spiro-epoxide with a chiral secondary alcohol, hemiacetal allylation and ring closing metathesis as the key steps for elaboration of the functionalized medium-ring ether moiety in laurencin.
authors.affiliation: Department of Chemistry, Memorial University, St. John's, Newfoundland, Canada.
authors.forename: Vikrant A
authors.initials: VA
authors.lastname: Adsool
authors.forename: Sunil V
authors.initials: SV
authors.lastname: Pansare
mesh_terms: D035964:Oxocins / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
chemical_list: D035964:Oxocins; C017460:laurencin