Apnea and its possible relationship to immunization in ex-premature infants.
This study compared the characteristics of infants hospitalized with apnea that participated in a vaccine trial compared with two control groups which consisted of 100 infants randomly selected from the same vaccine trial and 52 consecutively born very low birth weight (VLBW) infants. A total of 23 infants were admitted with apnea of whom 19 weighed <1500 g at birth and all were born at <37 weeks gestation. More of the VLBW infants in the apnea group had neonatal neurological complications compared with the VLBW control group (p=0.005). Ten of 11 children with apnea within 72 h of immunization were possibly related to vaccination.
Cooper
Peter A
PA
Department of Paediatrics, University of the Witwatersrand, South Africa.
Madhi
Shabir A
SA
Huebner
Robin E
RE
Mbelle
Nontombi
N
Karim
Salim S Abdool
SS
Kleinschmidt
Immo
I
Forrest
Bruce D
BD
Klugman
Keith P
KP
D001049:Apnea / Q000209:etiology*; D016022:Case-Control Studies; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D022242:Pneumococcal Vaccines / Q000009:adverse effects*
D022242:Pneumococcal Vaccines