Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis.
1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate) was prepared to probe the reaction mechanism of the putative zinc-dependent metalloenzyme 2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1-->6)-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis.
Crossman
Arthur T
AT
Division of Biological Chemistry and Drug Discovery, College of Life Sciences, The University of Dundee, DD1 5EH Dundee, Scotland, United Kingdom.
Urbaniak
Michael D
MD
Ferguson
Michael A J
MA
D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017261:Glycosylphosphatidylinositols / Q000096:biosynthesis*; D006918:Hydroxyurea / Q000737:chemistry; D007295:Inositol Phosphates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008667:Metalloproteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015394:Molecular Structure
C531984:1-6-O-(2-(N-hydroxyaminocarbonyl)amino-2-deoxyglucopyranosyl)inositol 1-(n-octadecyl phosphate); D004791:Enzyme Inhibitors; D017261:Glycosylphosphatidylinositols; D007295:Inositol Phosphates; D008667:Metalloproteins; D005944:Glucosamine; D006918:Hydroxyurea