[Bacterial spore--a new vaccine vehicle--a review].
Bacterial spores are robust and dormant life forms with formidable resistance properties. Spores of the genus Bacillus have been used for a long time as probiotics for oral bacteriotherapy both in humans and animals. Recently, genetically modified B. subtilis spores and B. anthracis spores have been used as indestructible delivery vehicles for vaccine antigens. They were used as vaccine vehicles or spore vaccine for oral immunization against tetanus and anthrax, and the results were very exciting. Unlike many second generation vaccine systems currently under development, bacterial spores offer heat stability and the flexibility for genetic manipulation. At the same time, they can elicit mucosal immune response by oral and nasal administration. This review focuses on the use of recombinant spores as vaccine delivery vehicles.
Wang
Yanchun
Y
Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China. springwyc@hotmail.com
Zhang
Zhaoshan
Z
D000818:Animals; D001408:Bacillus anthracis / Q000276:immunology; D001412:Bacillus subtilis / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D013171:Spores, Bacterial / Q000276:immunology* / Q000378:metabolism*; D014611:Vaccination
D001428:Bacterial Vaccines