[The relation between post-acute coronary syndrome anxiety and serum levels of inflammatory factors].
OBJECTIVE
To explore the role of inflammatory factors (interleukin-6, tumor necrosis factor alpha, high sensitive C reactive protein) in the pathogenesis of anxiety after acute coronary syndrome (ACS) by investigating the serum levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha) and high sensitive C reactive protein (hsCRP).


METHODS
Serum IL-6, TNFalpha and hsCRP levels were measured in 105 ACS patients within 7 days after onset of the event. Symptoms of anxiety were evaluated by self-reporting standardized questionnaire, using a validated Chinese version of Hospital Anxiety and Depression Scale (HADS-A)-Anxiety Subscale (7 items) within 72 hours of the event. Demographic and clinical data including cardiac risk factors were recorded.


RESULTS
The median of TNFalpha was lower in the anxious patients with ACS than that of non-anxious ones (44.55 vs 61.70, P = 0.004). Neither the levels of hsCRP nor the levels of IL-6 were found to be different between the groups with anxiety and without.


CONCLUSIONS
Anxiety after ACS does not increase the inflammatory reaction in the ACS patients.
Zhang
Jun-Meng
JM
Cardiology Department, Peking University People's Hospital, Beijing, China.
Ma
Wen-Lin
WL
Xu
Ying
Y
Li
Mei-Jing
MJ
Zhao
Ming-Zhong
MZ
Xing
Yan
Y
Zhu
Meng-Yun
MY
Hu
Da-Yi
DY
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000150:complications; D000368:Aged; D001007:Anxiety / Q000097:blood* / Q000209:etiology; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D018836:Inflammation Mediators; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein