Effect of resuscitation after selective cerebral ultraprofound hypothermia on expressions of nerve growth factor and glial cell line-derived neurotrophic factor in the brain of monkey.
OBJECTIVE
To investigate the expression of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) in monkeys of resuscitation after selective cerebral ultraprofound hypothermia and blood flow occlusion.


METHODS
The monkeys were immediately removed brain after death in operation of group A (identical temperature perfusion group) and group B (ultraprofound hypothermia perfusion group). Immunohistochemical technique was used to determine frontal cellular expression of NGF and GDNF. Statistics were analyzed by ANOVA analyses with significance level at P < 0.05.


RESULTS
The expressions of NGF and GDNF in the group B were significantly higher than those in the group A (P < 0.05).


CONCLUSIONS
NGF and GDNF increased significantly in the monkeys of resuscitation after selective cerebral ultraprofound hypothermia and blood flow occlusion. It may be a protective mechanism for neuron survival and neural function recovery.
Huang
Xue-Cai
XC
Department of Neurosurgery, Lishui Central Hospital, Lishui, China.
Xu
Wei
W
Jiang
Ji-Yao
JY
D000818:Animals; D001921:Brain / Q000378:metabolism; D002470:Cell Survival / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology; D002561:Cerebrovascular Disorders / Q000378:metabolism / Q000503:physiopathology; D019610:Cytoprotection / Q000502:physiology; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000378:metabolism*; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism* / Q000503:physiopathology / Q000517:prevention & control; D008253:Macaca mulatta; D020932:Nerve Growth Factor / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D020127:Recovery of Function / Q000502:physiology*; D015427:Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D012151:Resuscitation; D015854:Up-Regulation / Q000502:physiology
D051100:Glial Cell Line-Derived Neurotrophic Factor; D020932:Nerve Growth Factor