Silver(I)-catalyzed facile synthesis of pyrazoles from propargyl N-sulfonylhydrazones.
A silver(I)-catalyzed facile formation of pyrazoles from propargyl N-sulfonylhydrazones has been disclosed. During the reaction, a migration of sulfonyl groups (Ts, Ms) was observed. Good functional group compatibility was observed under mild reaction conditions (at room temperature for 3-5 h). This methodology allows for the efficient and regioselective synthesis of 1,3- and 1,5-disubstituted and 1,3,5-trisubstituted pyrazoles.
Lee
Young Tak
YT
Intelligent Textile System Research Center, Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, Korea.
Chung
Young Keun
YK
D002384:Catalysis; D006835:Hydrazones / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D012834:Silver / Q000737:chemistry*
D006835:Hydrazones; D011720:Pyrazoles; D012834:Silver