Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network.
The regulation and maintenance of systemic iron homeostasis is critical to human health. Iron overload and deficiency diseases belong to the most common nutrition-related pathologies across the globe. It is now well appreciated that the hormonal hepcidin/ferroportin system plays an important regulatory role for systemic iron metabolism. We review recent data that uncover the importance of the cellular iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network in systemic iron homeostasis. We also discuss how the IRE/IRP regulatory system communicates with the hepcidin/ferroportin system to connect the control networks for systemic and cellular iron balance.
Muckenthaler
Martina U
MU
Molecular Medicine Partnership Unit, Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, D-69120 Heidelberg, Germany.
Galy
Bruno
B
Hentze
Matthias W
MW
D000818:Animals; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000097:blood*; D000090463:Iron Deficiencies; D035925:Iron-Regulatory Proteins / Q000502:physiology*; D020218:Response Elements / Q000502:physiology
D035925:Iron-Regulatory Proteins; D007501:Iron