Biomaterials for the central nervous system.
Biomaterials are widely used to help treat neurological disorders and/or improve functional recovery in the central nervous system (CNS). This article reviews the application of biomaterials in (i) shunting systems for hydrocephalus, (ii) cortical neural prosthetics, (iii) drug delivery in the CNS, (iv) hydrogel scaffolds for CNS repair, and (v) neural stem cell encapsulation for neurotrauma. The biological and material requirements for the biomaterials in these applications are discussed. The difficulties that the biomaterials might face in each application and the possible solutions are also reviewed in this article.
Zhong
Yinghui
Y
Neurological Biomaterials and Therapeutics, Laboratory for Neuroengineering, Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA 30332, USA.
Bellamkonda
Ravi V
RV
D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage*; D002493:Central Nervous System Diseases / Q000628:therapy*; D002557:Cerebrospinal Fluid Shunts; D006801:Humans; D020100:Hydrogels; D015918:Infusion Pumps, Implantable; D019736:Prostheses and Implants
D001672:Biocompatible Materials; D020100:Hydrogels