title: Oesophageal aspergillosis in a case of acute lymphoblastic leukaemia successfully treated with caspofungin alone due to liposomal amphotericin B induced severe hepatotoxicity.
abstract: Aspergillosis is one of the most common invasive fungal infections in immunocompromised patients. Sinonasal region and upper respiratory tract are commonly involved regions whereas oesophagus is seldom involved. We present an 18-year-old male with acute lymphoblastic leukaemia with aspergillosis of oesophagus which is a rare region of involvement. The diagnosis was confirmed by the examination of the cultures of endoscopic biopsy material. The patient was already receiving empirical liposomal amphotericin B, due to severe hepatotoxicity the therapy was switched to another antifungal (caspofungin). Here we report a case of successful treatment of invasive oesophageal aspergillosis by caspofungin.
authors.forename: A
authors.initials: A
authors.lastname: Akyol Erikci
authors.forename: M
authors.initials: M
authors.lastname: Ozyurt
authors.forename: H
authors.initials: H
authors.lastname: Terekeci
authors.forename: A
authors.initials: A
authors.lastname: Ozturk
authors.forename: O
authors.initials: O
authors.lastname: Karabudak
authors.forename: K
authors.initials: K
authors.lastname: Oncu
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000009:adverse effects / Q000633:toxicity*; D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use* / Q000633:toxicity*; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy*; D000077336:Caspofungin; D054714:Echinocandins / Q000627:therapeutic use*; D004935:Esophageal Diseases / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D055666:Lipopeptides; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; C068538:liposomal amphotericin B; D000666:Amphotericin B; D000077336:Caspofungin