[Effect of continuous blood purification for management of multiple organ failure with acute renal failure].
OBJECTIVE
To evaluate the effect of continuous blood purification (CBP) for treatment of multiple organ failure (MOF) with acute renal failure (ARF).


METHODS
Forty-seven patients with MOF underwent CBP for an average of 3.1-/+0.5 days averagely. Continuous veno-venous hemofiltration was performed at daytime, and the substitute fluids were infused with pre-dilution at the rate of 2000-4000 ml/h. The general conditions, clinical symptoms, and serum biochemical indexes of the patients were observed and MODS score was calculated.


RESULTS
After CBP, the MODS score of the patients decreased significantly from 9.1-/+3.5 to 5.4-/+2.7 (P<0.01) and serum creatinine decreased from 451.3-/+134.5 to 223.7-/+100.2 micromol/L (P<0.05). Twenty-nine patients survived with the survival rate of 61.7%.


CONCLUSIONS
CBP is effective for treatment of MOF and may help reduce the mortality rate of MOF complicated by ARF.
Chen
Lu
L
Department of Nephrology, Shenzhen Sixth People's Hospital, Shenzhen 518052, China. fanghc-0397@sohu.com
Li
Jiu-hong
JH
Jiang
Ying
Y
Zhu
Sheng-lang
SL
Zhang
Jun
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology / Q000628:therapy*; D010195:Pancreatitis / Q000150:complications; D051437:Renal Insufficiency / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000150:complications; D055815:Young Adult