Mechanisms of inflammation induced tissue injury in multiple sclerosis.
Understanding the mechanisms of tissue injury in multiple sclerosis brains is a prerequisite for specific protective therapy. Here we review recent data, suggesting that demyelination and axonal injury in MS may be induced by different mechanisms involving adaptive and innate immunity. The relative contribution of the different immune reactions may in part explain the inter-individual and stage dependent heterogeneity of multiple sclerosis lesions.
Lassmann
Hans
H
Centre for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Wien, Austria. hans.lassmann@meduniwien.ac.at
D000818:Animals; D001369:Axons / Q000276:immunology / Q000473:pathology; D001921:Brain / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D009103:Multiple Sclerosis / Q000150:complications / Q000473:pathology*