title: Gene expression profile in cerebrum in the filial imprinting of domestic chicks (Gallus gallus domesticus).
abstract: In newly hatched chicks, gene expression in the brain has previously been shown to be up-regulated following filial imprinting. By applying cDNA microarrays containing 13,007 expressed sequence tags, we examined the comprehensive gene expression profiling of the intermediate medial mesopallium in the chick cerebrum, which has been shown to play a key role in filial imprinting. We found 52 up-regulated genes and 6 down-regulated genes of at least 2.0-fold changes 3h after the training of filial imprinting, compared to the gene expression of the dark-reared chick brain. The up-regulated genes are known to be involved in a variety of pathways, including signal transduction, cytoskeletal organization, nuclear function, cell metabolism, RNA binding, endoplasmic reticulum or Golgi function, synaptic function, ion channel, and transporter. In contrast, fewer genes were down-regulated in the imprinting, coinciding with the previous data that the total RNA synthesis increased associated with filial imprinting. Our data suggests that the filial imprinting involves the modulation of multiple signaling pathways.
authors.affiliation: Faculty of Pharmaceutical Sciences, Teikyo University, 1091-1 Sagamiko, Sagamihara, Kanagawa 229-0195, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Ikuko
authors.initials: I
authors.lastname: Fujii-Taira
authors.forename: Sachiko
authors.initials: S
authors.lastname: Katagiri
authors.forename: Ei-Ichi
authors.initials: E
authors.lastname: Izawa
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Hideaki
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Takano
authors.forename: Toshiya
authors.initials: T
authors.lastname: Matsushima
authors.forename: Koichi J
authors.initials: KJ
authors.lastname: Homma
mesh_terms: D000818:Animals; D054022:Cerebrum / Q000033:anatomy & histology / Q000502:physiology*; D002645:Chickens / Q000235:genetics / Q000502:physiology; D020224:Expressed Sequence Tags; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D007173:Imprinting, Psychological; D007858:Learning / Q000502:physiology; D008969:Molecular Sequence Data; D020411:Oligonucleotide Array Sequence Analysis; D015398:Signal Transduction / Q000502:physiology