Sentinel node biopsy for squamous cell carcinoma of the head and neck.
The clinical utility of sentinel node biopsy for melanoma has led multiple investigators to apply this approach to other cutaneous malignancies as well as to early cancers of the upper aerodigestive tract. Data are most extensive for oral cancer. A multi-institutional pathologic validation trial for selected oral cancers provided negative predictive values of 96%. Subsequent trials should document clinical follow-up. This technique may ultimately play a wider role in the management of mucosal cancers.
Civantos
Francisco
F
University of Miami, Miami, Florida 33136, USA. fcivanto@med.miami.edu
Zitsch
Robert
R
Bared
Anthony
A
Amin
Ayman
A
D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002986:Clinical Trials as Topic; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D037981:Neck Dissection; D018570:Risk Assessment; D021701:Sentinel Lymph Node Biopsy / Q000009:adverse effects; D012878:Skin Neoplasms / Q000473:pathology