Serum hyperglycosylated human chorionic gonadotropin to predict the gestational outcome in in vitro fertilization/intracytoplasmic sperm injection pregnancies.
Hyperglycosylated human chorionic gonadotropin (H-hCG) is secreted by the placenta in early pregnancy. Decreased H-hCG levels have been associated with abortion in spontaneous pregnancy. We retrospectively measured H-hCG and dimeric hCG in the sera of 87 in vitro fertilization patients obtained in the 3 weeks following embryo transfer and set the results in relation to pregnancy outcome. H-hCG and dimeric hCG were correlated (r(2) = 0.89), and were significantly decreased in biochemical pregnancy (2 microg/l and 18 IU/l, respectively) compared to early pregnancy loss (22 microg/l and 331 IU/l) and ongoing pregnancy (32 microg/l and 353 IU/l). Only H-hCG tended to discriminate between these last two groups.
Bersinger
N A
NA
Department of Obstetrics and Gynaecology, University of Berne, Berne, Switzerland. nick.bersinger@dkf.unibe.ch
Wunder
D M
DM
Nicolas
M
M
Birkhäuser
M H
MH
Porquet
D
D
Guibourdenche
J
J
D006063:Chorionic Gonadotropin / Q000097:blood* / Q000378:metabolism; D005260:Female; D005307:Fertilization in Vitro; D006031:Glycosylation; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011258:Pregnancy Tests / Q000379:methods*; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic
D006063:Chorionic Gonadotropin