Drug use, high-risk sex behaviors, and increased risk for recent HIV infection among men who have sex with men in Chicago and Los Angeles.
We examined how drugs, high-risk sexual behaviors, and socio-demographic variables are associated with recent HIV infection among men who have sex with men (MSM) in a case-control study. Interviewers collected risk factor data among 111 cases with recent HIV infection, and 333 HIV-negative controls from Chicago and Los Angeles. Compared with controls, cases had more unprotected anal intercourse (UAI) with both HIV-positive and HIV-negative partners. MSM with lower income or prior sexually transmitted infections (STI) were more likely to be recently HIV infected. Substances associated with UAI included amyl nitrate ("poppers"), methamphetamine, Viagra (or similar PDE-5 inhibitors), ketamine, and gamma hydroxybutyrate (GHB). Cases more frequently used Viagra, poppers, and methamphetamine during UAI compared with controls. In multivariate analysis, income, UAI with HIV-positive partners, Viagra, and poppers remained associated with recent HIV seroconversion. Better methods are needed to prevent HIV among MSM who engage in high-risk sex with concurrent drug use.
Carey
James W
JW
Prevention Research Branch, Division of HIV/AIDS Prevention, Centers for Disease Control & Prevention, Atlanta, GA, 30333, USA. jfc9@cdc.gov
Mejia
Roberto
R
Bingham
Trista
T
Ciesielski
Carol
C
Gelaude
Deborah
D
Herbst
Jeffrey H
JH
Sinunu
Michele
M
Sey
Ekow
E
Prachand
Nikhil
N
Jenkins
Richard A
RA
Stall
Ron
R
D000328:Adult; D016022:Case-Control Studies; D000697:Central Nervous System Stimulants / Q000009:adverse effects; D002641:Chicago / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission; D018451:Homosexuality, Male / Q000706:statistics & numerical data*; D006801:Humans; D015141:Los Angeles / Q000453:epidemiology; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects; D011687:Purines / Q000009:adverse effects; D012307:Risk Factors; D012309:Risk-Taking; D000068677:Sildenafil Citrate; D012959:Socioeconomic Factors; D019966:Substance-Related Disorders / Q000453:epidemiology*; D013450:Sulfones / Q000009:adverse effects; D011795:Surveys and Questionnaires; D014665:Vasodilator Agents / Q000009:adverse effects
D000697:Central Nervous System Stimulants; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D008694:Methamphetamine; D000068677:Sildenafil Citrate