title: Effects of bemiparin, dalteparin, and unfractionated heparin on platelet interaction with human subendothelium under flow conditions.
abstract: We compared the effects of the low-molecular-weight heparin (LMWH), bemiparin, and dalteparin with unfractionated heparin (UFH) on the platelet subendothelium interaction under flow conditions. All three compounds decreased the percentage of subendothelial matrix covered by platelets, although the effect of LMWH was greater than that of UFH. Subendothelial matrix covered with platelet structures greater than 100 square microns was significantly reduced by all three compounds; the effect of bemiparin tended to be greater than that of the other two heparins.
authors.affiliation: Department of Pharmacology and Therapeutics, School of Medicine, University of Málaga, Spain.
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: González-Correa
authors.forename: María Monsalud
authors.initials: MM
authors.lastname: Arrebola
authors.forename: Francisco
authors.initials: F
authors.lastname: Mérida
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Navas
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: López-Villodres
authors.forename: Felisa
authors.initials: F
authors.lastname: Samanes
authors.forename: José Pedro De La
authors.initials: JP
authors.lastname: Cruz
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects*; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D017985:Dalteparin / Q000494:pharmacology*; D042783:Endothelial Cells / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology*; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011673:Pulsatile Flow; D013314:Stress, Mechanical
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D006493:Heparin; C411345:bemiparin; D017985:Dalteparin