title: Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians.
abstract: We performed a genome-wide association study with 23,465 microsatellite markers to identify genes related to adult height. Selective genotyping was applied to extremely tall and extremely short individuals from the Khalkh-Mongolian population. Two loci, 8q21.13 and 15q22.33, which showed the strongest association with microsatellites were subjected to further analyses of SNPs in 782 tall and 773 short individuals. The most significant association was observed with SNP rs2220456 at 8q21.13 (P = 0.000016). In the LD block at 15q22.32, SNP rs8038652 located in intron 1 of IQCH was strongly associated (P = 0.0003), especially the AA genotype of the SNP under a recessive model was strongly associated with adult height (P = 0.000046).
authors.affiliation: Department of Molecular Life Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan, tekimura@is.icc.u-tokai.ac.jp.
authors.forename: Tetsuaki
authors.initials: T
authors.lastname: Kimura
authors.forename: Terukazu
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Batmunkh
authors.initials: B
authors.lastname: Munkhbat
authors.forename: Ganjuur
authors.initials: G
authors.lastname: Oyungerel
authors.forename: Tsolmon
authors.initials: T
authors.lastname: Bilegtsaikhan
authors.forename: Damdinsuren
authors.initials: D
authors.lastname: Anar
authors.forename: Jamiyansuren
authors.initials: J
authors.lastname: Jambaldorj
authors.forename: Sodnom
authors.initials: S
authors.lastname: Munkhsaikhan
authors.forename: Namid
authors.initials: N
authors.lastname: Munkhtuvshin
authors.forename: Hideki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Akira
authors.initials: A
authors.lastname: Oka
authors.forename: Ituro
authors.initials: I
authors.lastname: Inoue
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001827:Body Height / Q000235:genetics*; D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D002898:Chromosomes, Human, Pair 8; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005828:Genetics, Population; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D008986:Mongolia; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci