title: Hypereosinophilia associated with increased serum levels of carcinoembryonic antigen.
abstract: We report a case of hypereosinophilia associated with increased serum levels of carcinoembryonic antigen (CEA). The patient developed fever, diarrhea, erythroderma and eosinophilia. Disorders known to be associated with eosinophilia were not detected. The typical malignant diseases related to a rise in CEA levels were not identified. The CEA value reached a maximum of 81.4 ng/ml a few weeks late for the peak of the eosinophilic count. Corticosteroid therapy was effective in improving clinical symptoms and the CEA values decreased in association with the improvement of those manifestations, suggesting a pathophysiological link between the disease activity of hypereosinophilia and the changes in CEA level.
authors.affiliation: Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo. h-iwata@jikei.ac.jp
authors.forename: Hiroka
authors.initials: H
authors.lastname: Iwata
authors.forename: Nobuo
authors.initials: N
authors.lastname: Tsuboi
authors.forename: Takeo
authors.initials: T
authors.lastname: Ishii
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Hara
authors.forename: Ichiro
authors.initials: I
authors.lastname: Okido
authors.forename: Hajime
authors.initials: H
authors.lastname: Takahashi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kawamura
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Hosoya
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D002272:Carcinoembryonic Antigen / Q000097:blood* / Q000187:drug effects; D003873:Dermatitis, Exfoliative / Q000188:drug therapy / Q000209:etiology; D003928:Diabetic Nephropathies / Q000150:complications / Q000628:therapy; D003956:Dialysis; D003967:Diarrhea / Q000209:etiology; D004802:Eosinophilia / Q000188:drug therapy / Q000209:etiology; D005334:Fever / Q000209:etiology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008297:Male
chemical_list: D000305:Adrenal Cortex Hormones; D002272:Carcinoembryonic Antigen