Effect of enrofloxacin administration on excretion of Salmonella ententidis by experimentally infected chickens and on quinolone resistance of their Escherichia coli flora.
Chickens which had been experimentally-infected with a strain of Salmonella ententidis and treated by administration of enrofloxacin at commercially recommended concentrations in the drinking water, virtually eliminated this organism from the alimentary tract. However, an initially quinolone-sensitive Escherichia coli flora present in the birds' faeces was rapidly replaced by a quinolone-resistant flora which persisted after withdrawal of the medication. Resistance to quinolone in the form of nalidixic acid was transducible from a strain of S. typhimurium to S. enterinais with bacteriophage P22.
Barrow
P A
PA
Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire, UK.
Lovell
M A
MA
Szmolleny
G
G
Murphy
C K
CK