A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab.
We report the case of a 55-year-old Japanese woman with reactive AA amyloidosis associated with rheumatoid arthritis, in which inflammatory disease was completely suppressed with infliximab. Nephrotic syndrome was observed and renal biopsy specimens revealed amyloidosis deposits. Treatment with infliximab normalized the serum amyloid A (SAA) protein level, and subsequently nephritic syndrome disappeared and her creatinine clearance improved. Serial gastrointestinal biopsy specimens showed marked lasting regression of amyloid deposits. Thus treatment with infliximab represents an important therapeutic strategy for AA amyloidosis associated with RA.
Kuroda
Takeshi
T
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-Dori, Niigata City 951-8510, Japan. kurodat@med.niigata-u.ac.jp
Otaki
Yasuhiro
Y
Sato
Hiroe
H
Fujimura
Takeo
T
Nakatsue
Takeshi
T
Murakami
Syuichi
S
Sakatsume
Minoru
M
Nakano
Masaaki
M
Gejyo
Fumitake
F
D000686:Amyloidosis / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000069285:Infliximab; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D000685:Serum Amyloid A Protein; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D000911:Antibodies, Monoclonal; D000685:Serum Amyloid A Protein; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab