title: Nitric oxide-induced resistance or sensitization to death in tumor cells.
abstract: This report summarizes the present state of our knowledge pertaining to the NO-induced resistance or sensitization of tumor cell death. The effects of NO and its synergy with members of the TNF family, with cytotoxic drugs, and with ionizing radiations have been investigated. The dual effect of NO-induced resistance or sensitization and the underlying molecular mechanisms are discussed.
authors.affiliation: EPHE, Laboratoire d'immunologie et immunothérapie des cancers, Inserm, U866, Dijon, F-21000, France. jean-francois.Jeannin@u-bourgogne.fr
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Jeannin
authors.forename: Lissbeth
authors.initials: L
authors.lastname: Leon
authors.forename: Marion
authors.initials: M
authors.lastname: Cortier
authors.forename: Néjia
authors.initials: N
authors.lastname: Sassi
authors.forename: Catherine
authors.initials: C
authors.lastname: Paul
authors.forename: Ali
authors.initials: A
authors.lastname: Bettaieb
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy; D009569:Nitric Oxide / Q000502:physiology*; D011878:Radiotherapy; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide