4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function.
The T box transcription antitermination system is a riboswitch found primarily in Gram-positive bacteria which monitors the aminoacylation of the cognate tRNA and regulates a variety of amino acid-related genes. Novel 4,5-disubstituted oxazolidinones were identified as high affinity RNA molecular effectors that modulate the transcription antitermination function of the T box riboswitch.
Anupam
Rajaneesh
R
Department of Chemistry & Biochemistry, Ohio University, Athens, OH 45701, USA.
Nayek
Abhijit
A
Green
Nicholas J
NJ
Grundy
Frank J
FJ
Henkin
Tina M
TM
Means
John A
JA
Bergmeier
Stephen C
SC
Hines
Jennifer V
JV
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001412:Bacillus subtilis / Q000235:genetics; D015195:Drug Design; D008968:Molecular Conformation; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012329:RNA, Bacterial / Q000187:drug effects* / Q000235:genetics; D012343:RNA, Transfer / Q000187:drug effects* / Q000235:genetics; D013237:Stereoisomerism; D013728:Terminator Regions, Genetic / Q000187:drug effects / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects / Q000235:genetics
D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D012329:RNA, Bacterial; D012343:RNA, Transfer