title: 1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders.
abstract: This study assessed metabolic functioning of regional brain areas to address whether there is a neurometabolic profile reflecting the underlying neuropathology in individuals with autism spectrum disorders, and if varied profiles correlate with the clinical subtypes. Thirteen children (7-16 years) with autism spectrum disorders and 8 typically developing children were compared on (1)H-magnetic resonance spectroscopy data collected from hippocampus-amygdala and cerebellar regions. The autism spectrum disorder group had significantly lower N-acetyl-aspartate/creatine ratios bilaterally in the hippocampus-amygdala but not cerebellum, whereas myo-inositol/creatine was significantly increased in all measured regions. Choline/creatine was also significantly elevated in the left hippocampus-amygdala and cerebellar regions of children with autism spectrum disorder. Comparisons within the autism spectrum disorder group when clinically subdivided by history of speech delay revealed significant metabolic ratio differences. Magnetic resonance spectroscopy can provide important information regarding abnormal brain metabolism and clinical classification in autism spectrum disorders.
authors.affiliation: Weinberg Child Development Center, Safra Children's Hospital, Tel Hashomer, Israel. gabis@post.tau.ac.il
authors.forename: Lidia
authors.initials: L
authors.lastname: Gabis
authors.lastname: Wei Huang
authors.forename: Allen
authors.initials: A
authors.lastname: Azizian
authors.forename: Carla
authors.initials: C
authors.lastname: DeVincent
authors.forename: Alina
authors.initials: A
authors.lastname: Tudorica
authors.forename: Yael
authors.initials: Y
authors.lastname: Kesner-Baruch
authors.forename: Patricia
authors.initials: P
authors.lastname: Roche
authors.forename: John
authors.initials: J
authors.lastname: Pomeroy
mesh_terms: D000293:Adolescent; D000679:Amygdala / Q000378:metabolism; D000704:Analysis of Variance; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D020817:Asperger Syndrome / Q000175:diagnosis / Q000378:metabolism; D001321:Autistic Disorder / Q000175:diagnosis / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping; D016022:Case-Control Studies; D002531:Cerebellum / Q000378:metabolism; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000145:classification / Q000175:diagnosis / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D003071:Cognition / Q000502:physiology; D003401:Creatine / Q000378:metabolism*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011522:Protons; D012016:Reference Values; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D011522:Protons; D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline