Role of lipoprotein-associated phospholipase A2 in atherosclerosis.
Lipoprotein-associated phospholipase A(2)(Lp-PLA(2)) is a biomarker that can be used to assess the risk for cardiovascular disease and events. In addition to being a useful marker of a risk factor, several studies suggest that Lp-PLA(2) has a pathophysiologic role in the atherosclerotic disease process. In this article, we review this aspect and its therapeutic implications.
Lavi
Shahar
S
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
Herrmann
Joerg
J
Lavi
Ronit
R
McConnell
Joseph P
JP
Lerman
Lilach O
LO
Lerman
Amir
A
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000032:analysis / Q000187:drug effects / Q000502:physiology*; D054058:Acute Coronary Syndrome / Q000201:enzymology; D050197:Atherosclerosis / Q000175:diagnosis / Q000201:enzymology*; D015415:Biomarkers / Q000032:analysis; D003327:Coronary Disease / Q000201:enzymology; D042783:Endothelial Cells / Q000502:physiology; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology; D011379:Prognosis; D012307:Risk Factors; D020521:Stroke / Q000201:enzymology
D015415:Biomarkers; D000960:Hypolipidemic Agents; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase