Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress.
Cai
Lu
L
Department of Medicine, the University of Louisville, KY 40202, USA; Department of Radiation Oncology, the University of Louisville, KY 40202, USA; Department of Pharmacology and Toxicology, the University of Louisville, KY 40202, USA. Electronic address: L0cai001@louisville.edu.
D000079:Acetaldehyde / Q000378:metabolism; D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D000426:Alcohol Dehydrogenase / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D002310:Cardiomyopathy, Alcoholic / Q000201:enzymology* / Q000235:genetics; D002492:Central Nervous System Depressants / Q000378:metabolism / Q000633:toxicity*; D004721:Endoplasmic Reticulum / Q000201:enzymology* / Q000235:genetics; D000091342:Endoplasmic Reticulum Chaperone BiP; D004722:Endoribonucleases / Q000235:genetics / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism / Q000633:toxicity*; D015852:Eukaryotic Initiation Factor-2 / Q000235:genetics / Q000378:metabolism; D050991:GATA4 Transcription Factor / Q000235:genetics / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000235:genetics; D016758:Genes, jun / Q000187:drug effects / Q000235:genetics; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D055504:Insulin Receptor Substrate Proteins; D007333:Insulin Resistance / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism; D009200:Myocardial Contraction / Q000187:drug effects / Q000235:genetics; D032383:Myocytes, Cardiac / Q000201:enzymology; D010766:Phosphorylation / Q000187:drug effects; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects* / Q000235:genetics; D051742:Transcription Factor CHOP
D048868:Adaptor Proteins, Signal Transducing; D002492:Central Nervous System Depressants; C497250:Ddit3 protein, mouse; D000091342:Endoplasmic Reticulum Chaperone BiP; D015852:Eukaryotic Initiation Factor-2; D050991:GATA4 Transcription Factor; C484171:Gata4 protein, mouse; D006360:Heat-Shock Proteins; D007328:Insulin; D055504:Insulin Receptor Substrate Proteins; C526295:Irs1 protein, mouse; D018832:Molecular Chaperones; D051742:Transcription Factor CHOP; D000431:Ethanol; D000426:Alcohol Dehydrogenase; C510185:Ern1 protein, mouse; D000071679:Glycogen Synthase Kinase 3 beta; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3; D004722:Endoribonucleases; D000079:Acetaldehyde; D005947:Glucose