title: [Frequency and clinical, biochemical and histological characteristics of nonalcoholic fatty liver disease in patients with gallstone disease].
abstract: BACKGROUND
  In 1980, nonalcoholic fatty liver disease (NALFD) was described. It is related to the genesis of gallstones and is considered as a manifestation of the metabolic syndrome. In order to determine the frequency, anatomoclinical characteristics and biochemical and histological alterations in NAFLD, patients underwent cholecystectomy (GD). For this reason, we considered carrying out this study.
  
  
  METHODS
  This was a prospective and observational study. The study population was comprised of patients with gallstone disease who were treated at the "Hospital Español" in Veracruz, Mexico from January 1, 2005 to November 30, 2006 and underwent cholecystectomy and liver biopsy. Analyzed variables were anthropometric characteristics and risk factors, and in each patient biochemical tests, abdominal ultrasound (US) and histological liver study were performed.
  
  
  RESULTS
  In 95 patients, according to liver biopsy diagnoses, we found a frequency of 54.74% of NAFLD associated with gallstones. Females were more affected (71.15%) and the average age was 55.6 +/- 17.87 years. Risk factors were obesity (67.3%), diabetes mellitus (17.3%), and dyslipidemia (76.92%). Patients with NAFLD had elevated levels of glucose, glycosylated hemoglobin, cholesterol, triglycerides and HDLcholesterol, and aminotransferases. Abdominal US did not show sufficient specificity and sensitivity to detect NAFLD. Histological findings showed stage I steatosis in 51.93%, stage II in 28.84% and stage III in 19.23%. Cirrhosis was found in 3.15%.
  
  
  CONCLUSIONS
  Results of our study confirm the high frequency of NAFLD in association with gallstone disease. We consider this the first work to analyze and describe the primary clinical, biochemical and morphological characteristics.
authors.affiliation: Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Iturbide s/n, Veracruz, Mexico. federicoroesch@hotmail.com
authors.forename: Federico
authors.initials: F
authors.lastname: Roesch-Dietlen
authors.forename: Alfonso
authors.initials: A
authors.lastname: Pérez-Morales
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Melo-Santisteban
authors.forename: Fernando
authors.initials: F
authors.lastname: Díaz-Blanco
authors.forename: Silvia
authors.initials: S
authors.lastname: Martínez-Fernández
authors.forename: José Angel
authors.initials: JA
authors.lastname: Martínez
authors.forename: Silvia
authors.initials: S
authors.lastname: Cid-Juárez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000886:Anthropometry; D001706:Biopsy; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000453:epidemiology* / Q000601:surgery; D002784:Cholesterol / Q000378:metabolism; D015897:Comorbidity; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000209:etiology; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000378:metabolism; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D002784:Cholesterol