title: Preparation and Anti-Tumour Activity of Some Arylbismuth(III) Oxine Complexes.
abstract: New arylbismuth(lll) oxinates, PhBi(MeOx)(2), (p-MeC(6)H(4))Bi(Ox)(2), (p-MeC(6)H(4))Bi(MeOx)(2), (p-ClC(6)H(4))Bi(Ox)(2), and (p-ClC(6)H(4))Bi(MeOx)(2) (Ox(-) = quinolin-8-olate and MeOx(-)=2-methylquinolin-8-olate) have been prepared by reaction of the appropriate diarylbismuth chlorides with Na(Ox) or Na(MeOx) in the presence of 15-crown-5. An X-ray crystallographic study has shown PhBi(MeOx)(2) to be a five coordinate monomer with distorted square pyramidal stereochemistry. Chelating MeOx ligands have a cisoid arrangement in the square plane and the phenyl group is apical. The lattice is stabilised by significant pi-pi interactions between centrosymmetric molecules. A range of these complexes has been shown to have high in vitro biological activity (comparable with or better than cisplatin) against L1210 leukaemia, the corresponding cisplatin resistant line, and a human ovarian cell line, SKOV-3. However, initial in vivo testing against a solid mouse plasmacytoma (PC6) and P388 leukaemia has not revealed significant activity.
authors.affiliation: Department of Chemistry Monash University Clayton Victoria 3168 Australia.
authors.forename: K A
authors.initials: KA
authors.lastname: Smith
authors.forename: G B
authors.initials: GB
authors.lastname: Deacon
authors.forename: W R
authors.initials: WR
authors.lastname: Jackson
authors.forename: E R
authors.initials: ER
authors.lastname: Tiekink
authors.forename: S
authors.initials: S
authors.lastname: Rainone
authors.forename: L K
authors.initials: LK
authors.lastname: Webster