[Effect of adrenergic agents on NADPH oxydase evoked production of reactive oxygen species by macrophages].
The effects of adrenergic agonists (epinephrine, norepinephrine, isoprenaline, salbutamol, phenylephrine, clonidine) and antagonists (propranolol, sotalol, oxprenolol, methoprolol, atenolol) on the production of reactive oxygen (RO) by macrophages (MFs) were studied in vitro using chemiluminescence techniques. It was established that beta-adrenomimetics suppressed, whereas alpha-adrenomimetics enhanced or did not change the RO, production by MFs. Possible mechanisms and the biological significance of the adrenergic modulation NADPH-dependent RO, generation are discussed.
Bizunok
N A
NA
Dubovik
B V
BV
D018663:Adrenergic Agents / Q000494:pharmacology*; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D066298:In Vitro Techniques; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D019255:NADPH Oxidases / Q000378:metabolism*; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism*
D018663:Adrenergic Agents; D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D017382:Reactive Oxygen Species; D019255:NADPH Oxidases