title: Synthesis, structure and biological activity of 6-r(3)si(ge, sn)-substituted 5-fluorouracils.
abstract: Direct lithiation of 1-(2-tetrahydrofuryl)-5-fluorouracil (Ftorafur) has been investigated. The treatment of ftorafur with lithium diisopropylamide (LDA)at -70 in ether-hexane, followed by the reaction with various electrophiles afforded the corresponding 6-substituted silicon, germanium and tin derivatives of ftorafur. The results of biological investigation indicate the ability of germanium-modified nucleoside analogues to interfere with transcription and replication processes.
authors.affiliation: Latvian Institute of Organic Synthesis 21 Aizkraukles Riga LV-1006 Latvia.
authors.forename: E
authors.initials: E
authors.lastname: Lukevics
authors.forename: L
authors.initials: L
authors.lastname: Ignatovich
authors.forename: N
authors.initials: N
authors.lastname: Shilina
authors.forename: A
authors.initials: A
authors.lastname: Kemme
authors.forename: N
authors.initials: N
authors.lastname: Sjakste