title: Suicide behavior and neuropsychological assessment of type I bipolar patients.
abstract: BACKGROUND
  Neuropsychological deficits are often described in patients with bipolar disorder (BD). Some symptoms and/or associated characteristics of BD can be more closely associated to those cognitive impairments. We aimed to explore cognitive neuropsychological characteristics of type I bipolar patients (BPI) in terms of lifetime suicide attempt history.
  
  
  METHODS
  We studied 39 BPI outpatients compared with 53 healthy controls (HC) matched by age, educational and intellectual level. All subjects were submitted to a neuropsychological assessment of executive functions, decision-making and declarative episodic memory.
  
  
  RESULTS
  When comparing BDI patients, regardless of suicide attempt history or HC, we observed that bipolar patients performed worse than controls on measures of memory, attention, executive functions and decision-making. Patients with a history of suicide attempt performed worse than non-attempters on measures of decision-making and there were a significant negative correlation between the number of suicide attempts and decision-making results (block 3 and net score). We also found significant positive correlation between the number of suicide attempts and amount of errors in Stroop Color Word Test (part 3).
  
  
  CONCLUSIONS
  The sample studied can be considered small and a potentially confounding variable - medication status - were not controlled.
  
  
  CONCLUSIONS
  Our results show the presence of neuropsychological deficits in memory, executive functions, attention and decision-making in BPI patients. Suicide attempts BPI scored worse than non-suicide attempt BPI on measures of decision-making. More suicide attempts were associated with a worse decision-making process. Future research should explore the relationship between the association between this specific cognitive deficits in BPIs, serotonergic function and suicide behavior in bipolar patients as well other diagnostic groups.
authors.affiliation: Neurosciences And Neuropsychology Research Group, FUMEC University, Brazil.
authors.forename: Leandro F
authors.initials: LF
authors.lastname: Malloy-Diniz
authors.forename: Fernando Silva
authors.initials: FS
authors.lastname: Neves
authors.forename: Suzana Silva Costa
authors.initials: SS
authors.lastname: Abrantes
authors.forename: Daniel
authors.initials: D
authors.lastname: Fuentes
authors.forename: Humberto
authors.initials: H
authors.lastname: Corrêa
mesh_terms: D000328:Adult; D017668:Age of Onset; D000553:Ambulatory Care; D001288:Attention; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D015897:Comorbidity; D035061:Control Groups; D003657:Decision Making; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D013406:Suicide, Attempted / Q000523:psychology* / Q000706:statistics & numerical data