title: [Mast cell-rich aluminium granuloma].
abstract: Persistent subcutaneous nodules arise at the injection sites of aluminium hydroxide-absorbed hyposensitization solutions. We present a hitherto unreported phenomenon in aluminium granuloma. Two years after specific immunotherapy, a patient suffered increasingly from urticaria. Besides inflammatory infiltrates surrounding necrotic areas, microscopy of the specimen revealed numerous mast cells surrounding the necrotic tissue areas. The histological phenomenon of increased mast cell populations in aluminium granuloma might reflect the association with urticaria, which is probably more frequent than previously reported.
authors.affiliation: Institut für Pathologie, Johannes-Gutenberg-Universität Mainz, Langenbeckstrasse 1, 55101, Mainz. hansen@pathologie.klinik.uni-mainz.de
authors.forename: T
authors.initials: T
authors.lastname: Hansen
authors.forename: L
authors.initials: L
authors.lastname: Klimek
authors.forename: F
authors.initials: F
authors.lastname: Bittinger
authors.forename: I
authors.initials: I
authors.lastname: Hansen
authors.forename: F
authors.initials: F
authors.lastname: Capitani
authors.forename: A
authors.initials: A
authors.lastname: Weber
authors.forename: A
authors.initials: A
authors.lastname: Gatti
authors.forename: C J
authors.initials: CJ
authors.lastname: Kirkpatrick
mesh_terms: D000536:Aluminum Hydroxide / Q000009:adverse effects*; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology*; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects; D008297:Male; D009336:Necrosis; D014581:Urticaria / Q000139:chemically induced* / Q000473:pathology*; D055815:Young Adult
chemical_list: D000536:Aluminum Hydroxide