title: Squamous cell carcinoma of the nasolacrimal duct.
abstract: Tumors originating from the nasolacrimal duct are exceedingly rare. Only a few cases have been reported previously. In advanced cases with extended tumor, differential diagnosis from lacrimal sac tumor is difficult. A 68-year-old Japanese man with intractable dacryocystitis was examined with intranasal endoscopy, computed tomography (CT) and magnetic resonance imaging (MRI). Squamous cell carcinoma extended from a medial site in the left orbit to the lacrimal orifice. En bloc resection was performed and histopathological examination of the surgical specimen using serial section suggested that the origin of the tumor was located in the nasolacrimal duct. This is the first case in nasolacrimal duct carcinoma whose differential diagnosis of origin has been studied in detail. We showed that pathological study using serial section along the duct provides useful information for diagnosing the tumor origin in addition to that obtained from imaging studies.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan. hsakaida@clin.medic.mie-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakaida
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yuta
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Imanishi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Majima
mesh_terms: D000368:Aged; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003607:Dacryocystitis / Q000175:diagnosis; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009301:Nasolacrimal Duct / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D014057:Tomography, X-Ray Computed