GVHD pathophysiology: is acute different from chronic?
Graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic cell transplantation (HCT). GVHD occurs in acute and chronic forms. Acute GVHD usually manifests within 100 days following HSCT. It is induced by donor T cells responding to the mismatched host polymorphic histocompatibility antigens. Chronic GVHD generally manifests later (>100 days) and has some features of autoimmune diseases. It may develop either de novo or following resolution of - or as an extension of - acute GVHD. Chronic GVHD is also thought to be induced by donor T cells, but the nature of relevant antigens, the critical cellular subsets and the mechanisms of chronic GVHD remain less well understood. In this chapter we briefly discuss and contrast the pathophysiologies of acute and chronic GVHD.
Toubai
Tomomi
T
Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0942, USA.
Sun
Yaping
Y
Reddy
Pavan
P
D000208:Acute Disease; D000938:Antigen-Presenting Cells / Q000276:immunology; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D006087:Graft vs Host Reaction / Q000502:physiology; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D006680:HLA Antigens