title: Unusual granulomatous variant of scleromyxedema.
abstract: Scleromyxedema is notable for significant morbidity and mortality. A generalized eruption of waxy papules in the absence of thyroid disease with histologic findings of mucin deposition, increased fibroblast proliferation, and fibrosis are the characteristic features of scleromyxedema. We report a case of scleromyxedema that, on histology, was associated with interstitial granuloma annulare-like features. Based on our literature review, this is a rare presentation of this disease. Familiarity with the histologic aspects of scleromyxedema, as described in this report, can help to improve the accuracy of this diagnosis, particularly in atypical presentations.
authors.affiliation: Department of Pathology, University of Washington, Seattle, Washington 98195-6100, USA. gstetsen@u.washington.edu
authors.forename: Galina Y
authors.initials: GY
authors.lastname: Stetsenko
authors.forename: Jay C
authors.initials: JC
authors.lastname: Vary
authors.forename: John E
authors.initials: JE
authors.lastname: Olerud
authors.forename: Zsolt B
authors.initials: ZB
authors.lastname: Argenyi
mesh_terms: D003937:Diagnosis, Differential; D016460:Granuloma Annulare / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011537:Pruritus / Q000209:etiology; D053718:Scleromyxedema / Q000150:complications / Q000175:diagnosis* / Q000473:pathology