title: Cytotoxicity of Co(III) Complexes of Arginine.
abstract: The cytotoxicity of four Co(III) complexes of arginine on nontumour MDBK cells and on two cell lines derived from transplantable tumors, LSCC-SF(Mc29) and LSR-SF (SR), was evaluated comparative!y. Based on the cytotoxic concentration required to inhibit cell surveillance by 50% cc(nabla') it was found that: (i) the cytotoxicity of complexes tested increases when the concentration decreased; (ii) the cell surveillance depends on both complex and cell specificities. The complex specificity was illustrated by the order 1 > 4 > 2 >/= 3 . The cell specific response was demonstrated by the fact that LSCC-SG (Mc29) cells were up to 60 times more sensitive to 1 while LSR-SF (SR) cells were up to 1000 times more sensitive to 2 as compared to MDBK cells. Furthermore, with the prolongation of action on nontumour cells the cytotoxicity of 4 decreased up to 300 times while for both tumour cells it was independent on the duration of action.
authors.affiliation: Laboratory of Virology Faculty of Biology Sofia University 8 Dragan Tzankov Blvd. Sofia 1421 Bulgaria.
authors.forename: P
authors.initials: P
authors.lastname: Genova
authors.forename: T
authors.initials: T
authors.lastname: Varadinova
authors.forename: R
authors.initials: R
authors.lastname: Alexandrova
authors.forename: S
authors.initials: S
authors.lastname: Trifunovic
authors.forename: P
authors.initials: P
authors.lastname: Radivojsa