Hedgehog coordination of postnatal osteoclast and osteoblast activities.
The Hedgehog (Hh) pathway is important for skeletal patterning and morphogenesis during embryonic development. Papers by Ohba et al. and Mak et al. in this edition of Developmental Cell suggest that Hh signaling may exert delicate control over the activities of osteoclasts and osteoblasts, the cell types primarily responsible for bone resorption and formation.
Mundy
Gregory R
GR
Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. gregory.r.mundy@vanderbilt.edu
Yang
Xiangli
X
D000818:Animals; D000831:Animals, Newborn; D006801:Humans; D051379:Mice; D009929:Organ Size; D010006:Osteoblasts / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D010010:Osteoclasts / Q000378:metabolism* / Q000473:pathology; D010012:Osteogenesis; D044162:Parathyroid Hormone-Related Protein / Q000235:genetics; D000072079:Patched Receptors; D053245:RANK Ligand / Q000235:genetics; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction
D044162:Parathyroid Hormone-Related Protein; D000072079:Patched Receptors; D053245:RANK Ligand; D011956:Receptors, Cell Surface