title: Circadian expression of 86- and 84-kDa heat shock proteins in the mouse suprachiasmatic nucleus.
abstract: Circadian rhythm pervades in many aspects of the biological processes including basic cellular functions. Here we examined the circadian gene expression of two forms of 90 kDa heat shock proteins referred to HSP86 and HSP84 in the mouse suprachiasmatic nucleus, the circadian center. In both light-dark, and constant dark conditions, Hsp86 mRNA showed an overt circadian rhythm showing a peak at (subjective) night and a trough at (subjective) day. Hsp84 mRNA also showed the similar expression profile, but the amplitude was weaker. These results indicate that gene expression of molecular chaperone such as Hsp86 and Hsp84 are regulated by the circadian clock.
authors.affiliation: Division of Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Fukuyama
authors.forename: Masao
authors.initials: M
authors.lastname: Doi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Matsuo
authors.forename: Hiromi
authors.initials: H
authors.lastname: Nishinaga
authors.forename: Shigeru
authors.initials: S
authors.lastname: Miyake
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Okamura
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000235:genetics; D002940:Circadian Rhythm / Q000235:genetics; D005786:Gene Expression Regulation / Q000502:physiology; D018841:HSP90 Heat-Shock Proteins / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016548:Prosencephalon / Q000737:chemistry / Q000378:metabolism; D013493:Suprachiasmatic Nucleus / Q000737:chemistry / Q000378:metabolism*
chemical_list: C488983:HSP84 protein, mouse; D018841:HSP90 Heat-Shock Proteins; C107835:Hspca protein, mouse