Spontaneous self-assembly of water-soluble nucleotide-calixarene conjugates in small micelles coalescing to microspheres.
Spontaneous self-assembly of calix[4]arenes bearing four 2'-deoxythymidine or 2'-deoxyadenosine nucleotide pendants is investigated using (1)H NMR, exchange NMR, and diffusion ordered NMR spectroscopies and dynamic light scattering. In aqueous medium, the nucleotide-calixarene conjugates, by noncovalent interactions involving both nucleobases and calixarene skeleton, form dimers which self-organize in micelles by increasing the concentration. Microscopic images (scanning electron microscopy and transmission electron microscopy) show that the nucleobase affects the aggregate morphology in the solid state.
Consoli
Grazia M L
GM
Istituto Chimica Biomolecolare-C.N.R., Via del Santuario 110, 95028 Valverde (CT), Italy.
Granata
Giuseppe
G
Lo Nigro
Raffaella
R
Malandrino
Graziella
G
Geraci
Corrada
C
D000596:Amino Acids / Q000737:chemistry; D047250:Calixarenes / Q000737:chemistry*; D004261:DNA Replication; D019281:Dimerization; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008863:Microspheres; D008956:Models, Chemical; D008968:Molecular Conformation; D009711:Nucleotides / Q000737:chemistry*; D012542:Scattering, Radiation; D012995:Solubility; D014867:Water / Q000737:chemistry*
D000596:Amino Acids; D008823:Micelles; D009711:Nucleotides; D014867:Water; D047250:Calixarenes