HLA-DR2 and white matter lesion distribution in MS.
Human leukocyte antigen DR2 (HLA-DR2) is a well-established genetic risk factor for multiple sclerosis (MS). However, it is still unknown whether this factor is associated with a specific disease phenotype, and in particular, to a regional distribution of white matter (WM) lesion phenotype on magnetic resonance imaging (MRI). On a voxel-by-voxel basis, we analyzed the T1 and T2 MRI-derived lesion maps of 50 patients with MS in order to determine the possible influence of HLA-DR2 genotype on the lesional MRI pattern at early stages of the disease. HLA-DR2 was present in 15 (30%) patients of our cohort. They displayed similar WM lesion distribution as the subjects without this factor. Thus, lesion distribution in MS seems to be independent of the DR2 genotype.
Sepulcre
Jorge
J
Department of Neurology and Neurosurgery of the Clínica Universitaria de Navarra, Pamplona, Spain.
Masdeu
Joseph C
JC
Palacios
Ricardo
R
Goñi
Joaquín
J
Moreno
Beatriz
B
Tainta
Mikel
M
Bejarano
Bartolomé
B
Villoslada
Pablo
P
D000328:Adult; D005260:Female; D005838:Genotype; D015802:HLA-DR2 Antigen / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology*; D010641:Phenotype
D015802:HLA-DR2 Antigen