Inflammation and cancer: the oncogene-driven connection.
Inflammation has long been suspected to contribute to tumor growth. However, the concept that oncogenes, known for decades as responsible for cell neoplastic transformation, build up an inflammatory pro-tumorigenic microenvironment is emerging only in the last few years. The well known oncogenes RAS and MYC have been causally linked to tumor angiogenesis through different ways. Moreover, in thyroid tumors, where many of the genetic tumor-initiating events have been identified, the oncogenes driving tumorigenesis were proved able to induce an inflammatory program. This minireview will focus on growing evidence implicating the role of intrinsic, oncogene-driven pathways leading to pro-tumoral inflammation.
Borrello
Maria Grazia
MG
Department of Experimental Oncology, Operative Unit Molecular Mechanisms of Cancer Growth and Progression, IRCCS Istituto Nazionale dei Tumori Foundation, Via G. Venezian, 1 20133 Milan, Italy. mariagrazia.borrello@istitutotumori.mi.it
Degl'Innocenti
Debora
D
Pierotti
Marco A
MA
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000235:genetics / Q000473:pathology; D051379:Mice; D009369:Neoplasms / Q000098:blood supply / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics; D009857:Oncogenes