[Collagen gel droplet-embedded culture drug sensitivity test in human breast cancer].
The efficacy of the collagen gel droplet-embedded culture drug sensitivity test (CD-DST) was estimated clinically among breast cancer patients to select a rational chemotherapy. Twenty-five specimens of breast cancer (n=21) or lymph nodes (n=4) were investigated. Four anticancer drugs (5-Fluorouracil, Adriamycin (ADM), Docetaxel (DOC), Paclitaxel (PTX)) were estimated for CD-DST. Sixteen samples among 25 samples (64.0%) seemed to be worth estimation. The chemosensitivity values were as follows: 5-FU 30.8%, ADM 30.8%, DOC 53.8% and PTX 46.2%, respectively. Thus, CD-DST may predict the chemosensitivity with high accuracy in breast cancer patients and seems to be superior to the conventional predictors.
Yamamoto
Yuji
Y
Organ Regenerative Surgery, Ehime University Graduate School of Medicine.
Watanabe
Yuji
Y
Ishida
Naoki
N
Hidaka
Toshiko
T
Sugishita
Hiroki
H
Yoshida
Motohira
M
Yukumi
Shungo
S
Sato
Koichi
K
Nakagawa
Hiromichi
H
Horiuchi
Atsushi
A
Kawachi
Kanji
K
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy*; D003094:Collagen; D000077143:Docetaxel; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D005782:Gels; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000494:pharmacology; D043823:Taxoids / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D005782:Gels; D043823:Taxoids; D000077143:Docetaxel; D004317:Doxorubicin; D003094:Collagen; D017239:Paclitaxel; D005472:Fluorouracil