title: [A case of unresectable sigmoid colon cancer in an elderly patient responding to S-1].
abstract: An 88-year-old man with unresectable sigmoid colon cancer due to retroperitoneal invasion and massive LN metastasis was treated with S-1 after colostomy. S-1 (80 mg/body/day) was administered for 2 weeks followed by a one week interval. Colonoscopy and abdominal CT revealed a partial response. After 5 courses, the patient underwent sigmoidectomy. S-1 was then administered for 15 courses. There was no side effect, and hospitalization was not required during the treatment. This therapy was very feasible and convenient, obtained good compliance and enhanced the quality of life of this patient. S-1 is expected to be an effective agent for the treatment of advanced colon cancer in elderly patients in days to come.
authors.affiliation: Dept. of Surgery, Teramoto Memorial Hospital.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yanagawa
authors.forename: Nobuo
authors.initials: N
authors.lastname: Matsunaga
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nakagawa
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use*; D012811:Sigmoid Neoplasms / Q000188:drug therapy* / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid