Hypoglycemia associated with the production of insulin-like growth factor II in a pancreatic islet cell tumor: a case report.
An insulinoma is characterized by endogenous hyperinsulinemia and hypoglycemia. However, it has been reported that insulinomas with normal levels of plasma insulin and a normal insulin to glucose ratio occur in patients with hypoglycemia. Although overproduction of Insulin-like growth factor II (IGF-II) by non-islet cell tumors such as large mesenchymal tumors, can cause hypoglycemia, no cases of circulating plasma IGF-II from an islet cell tumor contributing to hypoglycemia have been reported. We report here a rare case of a pancreatic islet tumor in a patient with hypoglycemia that was associated with increased plasma IGF-II, which returned to normal after tumor resection.
Chung
Jin Ook
JO
Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Hong
Se In
SI
Cho
Dong Hyeok
DH
Lee
Jae Hyuk
JH
Chung
Dong Jin
DJ
Chung
Min Young
MY
D000368:Aged; D018273:Carcinoma, Islet Cell / Q000097:blood / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology* / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D007515:Islets of Langerhans / Q000378:metabolism* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000097:blood / Q000150:complications* / Q000378:metabolism / Q000601:surgery
C035170:IGF2 protein, human; D007335:Insulin-Like Growth Factor II