Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics.
Bile acids and bile alcohols in the form of their conjugates are amphipathic end products of cholesterol metabolism with multiple physiological functions. The great variety of bile acids and bile alcohols that are present in vertebrates are tabulated. Bile salts have an enterohepatic circulation resulting from efficient vectorial transport of bile salts through the hepatocyte and the ileal enterocyte; such transport leads to the accumulation of a pool of bile salts that cycles between the liver and intestine. Bile salt anions promote lipid absorption, enhance tryptic cleavage of dietary proteins, and have antimicrobial effects. Bile salts are signaling molecules, activating nuclear receptors in the hepatocyte and ileal enterocyte, as well as an increasing number of G-protein coupled receptors. Bile acids are used therapeutically to correct deficiency states, to decrease the cholesterol saturation of bile, or to decrease the cytotoxicity of retained bile acids in cholestatic liver disease.
Hofmann
A F
AF
Department of Medicine, University of California, San Diego, La Jolla, California 92093-0063, USA. ahofmann@ucsd.edu
Hagey
L R
LR
D000818:Animals; D001647:Bile Acids and Salts / Q000737:chemistry* / Q000378:metabolism*; D001660:Biliary Tract Diseases / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy*; D001692:Biological Transport; D001775:Blood Circulation; D002352:Carrier Proteins / Q000378:metabolism; D004764:Enterohepatic Circulation; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism
D001647:Bile Acids and Salts; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; C037643:bile acid binding proteins