Labdane-type diterpenes active against acne from pine cones (Pinus densiflora).
Bioassay-guided extraction and fractionation of the aqueous methanolic extract of the cones of Pinus densiflora (Pinaceae) afforded one new labdane-type diterpene aldehyde, 15-nor-14-oxolabda-8(17),12 E-diene-18-oic acid, along with eight known diterpenes. Their structures were elucidated using spectroscopic methods as well as by comparison with previously reported data. The isolates showed antibacterial (Propionibacterium acnes) and antifungal activities.
Sultan
Md Zakir
MZ
Department of Chemistry, Kongju National University, Kongju, Korea.
Jeon
Young-Min
YM
Moon
Surk-Sik
SS
D000152:Acne Vulgaris / Q000188:drug therapy; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D028223:Pinus / Q000737:chemistry*; D011425:Propionibacterium acnes / Q000187:drug effects
D000900:Anti-Bacterial Agents; D004224:Diterpenes