title: The risk of developing a second, different, cancer among 14 560 survivors of malignant cutaneous melanoma: a study by AIRTUM (the Italian Network of Cancer Registries).
abstract: The aim of this study was to provide further quantitative data on the risk of second nonmelanoma cancers in patients with cutaneous malignant melanoma (CMM). A cohort of 14 560 population-based patients from the Italian Network of Cancer Registries incident during 1985-2002 were included and followed up for further incident cases and vital status. Standardized incidence ratios (SIR) were used to compare the number of observed second cancers with expected cancers. In a total of 69 581 person-years, 1020 second cancers were registered, of which 804.6 were expected (SIR=1.27; 95% confidence interval 1.19-1.35). The risk was similar for males and females, (SIR=1.27 and 1.26, respectively). The risk was slightly higher among younger (<60 years; SIR=1.44) than older (60+ years; SIR=1.19) patients. The overall risk in the period after CMM diagnosis did not change significantly (SIR=1.34 during the first 5 years and 1.12 afterwards). No differences in the overall risk were evident in different years of diagnosis, for different melanoma morphology types or for different geographical areas within Italy. Statistically significantly increased risks were found for nonmelanoma skin cancers [observed number (n)=362, SIR=3.12], for bone (n=5, SIR=6.08) and for kidney cancers (n=39, SIR=1.95) and lower than expected risks were found for liver (SIR=0.46) and lung cancers (SIR=0.71). We confirm that CMM patients are at high risk for nonmelanoma skin cancers. The reasons for the increased risk of kidney and bone cancers are not yet clear.
authors.affiliation: Tuscany Cancer Registry, Clinical and Descriptive Epidemiology Unit, CSPO, Florence, Italy. e.crocetti@cspo.it
authors.forename: Emanuele
authors.initials: E
authors.lastname: Crocetti
authors.forename: Stefano
authors.initials: S
authors.lastname: Guzzinati
authors.forename: Eugenio
authors.initials: E
authors.lastname: Paci
authors.forename: Fabio
authors.initials: F
authors.lastname: Falcini
authors.forename: Roberto
authors.initials: R
authors.lastname: Zanetti
authors.forename: Marina
authors.initials: M
authors.lastname: Vercelli
authors.forename: Ivan
authors.initials: I
authors.lastname: Rashid
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Lisi
authors.forename: Antonio
authors.initials: A
authors.lastname: Russo
authors.forename: Susanna
authors.initials: S
authors.lastname: Vitarelli
authors.forename: Stefano
authors.initials: S
authors.lastname: Ferretti
authors.forename: Lucia
authors.initials: L
authors.lastname: Mangone
authors.forename: Rosaria
authors.initials: R
authors.lastname: Cesaraccio
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Fabio
authors.initials: F
authors.lastname: Pannozzo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008545:Melanoma / Q000453:epidemiology*; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology / Q000209:etiology*; D012042:Registries; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology*; D017741:Survivors / Q000706:statistics & numerical data