Insulin-like growth factor-1 receptor polymorphism and ischemic stroke: a case-control study in Chinese population.
OBJECTIVE
Low levels of insulin-like growth factor 1 (IGF-1) are associated with atherosclerosis, and insulin-like growth factor-1 receptor (IGF-1R) polymorphisms can change plasma levels of IGF-1 and may alter the function of the receptor. Whether there is any association of genetic variation in IGF-1R gene with ischemic stroke (IS) is presently unknown.


METHODS
A 1:1 case-control study was conducted. The G --> A polymorphism of IGF-1R gene (rs2229765) were analyzed by TaqMan SNP genotyping technique in Chinese patients with IS (n = 309) and old subjects without IS (n = 309).


RESULTS
The frequency of A allele in the patients and controls was 45.79% and 39.64%, respectively. The AA genotype distribution of IGF-1R gene was significantly higher in the patients (27.51%) than controls (18.23%; P = 0.022). Conditional logistic regression revealed that the AA genotype of IGF-1R was associated with IS (OR = 1.641, P = 0.022). After adjustment for smoking, alcohol drinking, history of hypertension, and body mass index, IGF-1R AA genotype was still significantly associated with an increased risk of IS (OR = 1.787, P = 0.029), compared with IGF-1R GG.


CONCLUSIONS
The G --> A polymorphism in IGF-1R gene may affect the susceptibility to IS in Chinese population.
Cheng
J
J
Department of Molecular Biology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China. c_jinquan@126.com
Liu
J
J
Li
X
X
Peng
J
J
Han
S
S
Zhang
R
R
Xu
Y
Y
Nie
S
S
D000367:Age Factors; D000368:Aged; D001483:Base Sequence / Q000235:genetics; D002545:Brain Ischemia / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D016022:Case-Control Studies; D002536:Cerebral Arteries / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002681:China; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D002537:Intracranial Arteriosclerosis / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D017526:Receptor, IGF Type 1 / Q000235:genetics* / Q000378:metabolism; D020521:Stroke / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D015854:Up-Regulation / Q000235:genetics
D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1