title: [Severe lactic acidosis caused by propofol infusion: report of one case].
abstract: Propofol infusion syndrome (PRIS) is a rare but potentially lethal complications. This disorder is triggered under unknown circumstances by a propofol infusion of more than 5 mg/kg/h for more than 48 h. PRIS is characterized by a multiorgan failure and rhabdomyolysis and is induced by a disturbance in mitochondrial long chain fatty acid oxidation. We report a 43 year-old woman who underwent brain surgery due to a vascular malformation. In the immediate postoperative period, she had an unexplained and severe lactic acidosis. During anaesthesia, she received a propofol infusion of 7 mg/kg/h that continued in the UCI at a rate of 3.5 mg/kg/h, for 8 hours more. The suspicion of PRIS motivated immediate discontinuation of propofol with rapid correction of lactic acidosis and full recovery of the patient.
authors.affiliation: Intensive Care Unit, Hospital Clínico Universidad de Chile, Santiago de Chile. caromero@redclinicauchile.cl
authors.forename: Carlos
authors.initials: C
authors.lastname: Romero P
authors.forename: Mónica
authors.initials: M
authors.lastname: Morales R
authors.forename: Luisa
authors.initials: L
authors.lastname: Donaire R
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Llanos V
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Cornejo R
authors.forename: Ricardo
authors.initials: R
authors.lastname: Gálvez A
authors.forename: José
authors.initials: J
authors.lastname: Castro O
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000175:diagnosis; D000328:Adult; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D007262:Infusions, Intravenous; D007431:Intraoperative Complications / Q000139:chemically induced; D015742:Propofol / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D015742:Propofol