IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.
Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a]pyridino-pyridines and benzimidazolo-pyridines was explored.
Buckley
George M
GM
UCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK.
Fosbeary
Richard
R
Fraser
Joanne L
JL
Gowers
Lewis
L
Higueruelo
Alicia P
AP
James
Lynwen A
LA
Jenkins
Kerry
K
Mack
Stephen R
SR
Morgan
Trevor
T
Parry
David M
DM
Pitt
William R
WR
Rausch
Oliver
O
Richard
Marianna D
MD
Sabin
Verity
V
D004353:Drug Evaluation, Preclinical; D053592:Interleukin-1 Receptor-Associated Kinases / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D047428:Protein Kinase Inhibitors; D011725:Pyridines; D053592:Interleukin-1 Receptor-Associated Kinases; C001439:imidazo(1,2-a)pyridine