Roles of TRESK, a novel two-pore domain K+ channel, in pain pathway and general anesthesia.
TRESK is the most recently reported two-pore domain K+ channel, and different from other two-pore domain channels in gene, molecular structure, electrophysiological and pharmacological properties. Although the current knowledge of this potassium channel is inadequate, researches have demonstrated that TRESK is remarkablely linked to acute and chronic pain by activation of calcineurin. The fact that TRESK is sensitive to volatile anesthetics and localization in central nerve system implies that TRESK may play a very important role in the mechanism mediating general anesthesia. The further research of TRESK may contribute to explore the underlying mechanism of some pathological conditions and yield novel treatments for some diseases.
Huang
Dong-Yue
DY
Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yu
Bu-Wei
BW
Fan
Qiu-Wei
QW
D000595:Amino Acid Sequence / Q000502:physiology; D018681:Anesthetics, General / Q000494:pharmacology*; D000818:Animals; D019703:Calcineurin / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism*; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D010146:Pain / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D017933:Peripheral Nervous System / Q000187:drug effects / Q000378:metabolism; D015221:Potassium Channels / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*
D018681:Anesthetics, General; C476574:KCNK18 protein, human; D015221:Potassium Channels; D019703:Calcineurin