Factors determining the formation and release of bioactive IL-12: regulatory mechanisms for IL-12p70 synthesis and inhibition.
IL-12 is an important type 1 immune activation cytokine. It is known that macrophages and dendritic cells the major cell types producing this cytokine and that these cells may release both the biologically inactive form (IL-12p40) and active form (IL-12p70) of IL-12. In this review, the latest information regarding the regulatory mechanisms governing the production of IL-12p70 by these cells is evaluated.
Zhang
Sheng
S
Medical Oncology, First People's Hospital, Shanghai Jiaotong University, 85 Wujin Road, Shanghai 200080, China. wozhangsheng@hotmail.com
Wang
Qin
Q
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D014644:Genetic Variation; D006801:Humans; D018664:Interleukin-12 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology; D051379:Mice
D018664:Interleukin-12