title: Health-related quality of life in survivors of BMT for paediatric malignancy: a systematic review of the literature.
abstract: We review evidence concerning health-related quality of life (HRQL) following paediatric haemopoietic stem cell transplant. The aims are to determine (1) HRQL compared with population norms; (2) changes in HRQL over time and (3) relations between pre-transplant variables (disease, individual and family resources) and survivor HRQL. Five databases were searched for articles published between January 1990 and February 2008. A total of 15 studies including 12 separate cohorts were identified. (1) HRQL was comparable with or better than population norms 6 months to 8 years post transplant. (2) HRQL was already compromised pre-transplant, further impaired immediately following conditioning, but improved 4-12 months post transplant. (3) Pre-transplant predictors of HRQL include family functioning and individual resources (for example, social skills). Identification of pre-transplant variables associated with long-term HRQL is invaluable to inform early psychological intervention and facilitate positive adjustment.
authors.affiliation: Department of Psychology, University of Sheffield, Western Bank, Sheffield, UK.
authors.forename: S-A
authors.initials: SA
authors.lastname: Clarke
authors.forename: C
authors.initials: C
authors.lastname: Eiser
authors.forename: R
authors.initials: R
authors.lastname: Skinner
mesh_terms: D002648:Child; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality / Q000523:psychology*; D006801:Humans; D011788:Quality of Life; D017741:Survivors