title: [Alterations of salivary flow rate and oral main pathogens in miniature pig with bilateral parotid gland atrophy].
abstract: OBJECTIVE
  To observe the effect of bilateral parotid gland atrophy on the whole saliva flow rate and the growth of main oral pathogens in different sites of oral cavity.
  
  
  METHODS
  Ten healthy miniature pigs were divided into two groups. The parotid glands of test group (n = 5) were bilaterally ablated by methyl violet. Another healthy five miniature pigs served as the control group. Whole saliva was collected and the whole saliva flow rate detected in both groups at 12 and 24 months respectively after parotid atrophy. The total numbers of oral main pathogens in the first molar, cuspid sub-gingival bacteria plaque and whole saliva were also detected.
  
  
  RESULTS
  The whole saliva flow rate was significantly decreased at both 12 and 24 months respectively after atrophy of bilateral parotid gland in miniature pig. Pathogens including Streptococcus mutans, Porphyromonas gingivalis and Fusobacterium nucleatum in different sites oral cavity were increased after bilateral parotid gland atrophy.
  
  
  CONCLUSIONS
  Bilateral ablation of the parotid glands led to a significant decrease of whole saliva flow rate. The total numbers of main oral pathogens were increased in different sites of oral cavity.
authors.affiliation: Salivary Gland Disease Center and The Molecular Laboratory for Gene Therapy, Faculty of Stomatology, Capital University of Medical Sciences, Beijing 100050, China.
authors.forename: Deng-sheng
authors.initials: DS
authors.lastname: Xia
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Chun-mei
authors.initials: CM
authors.lastname: Zhang
authors.forename: Sheng-hui
authors.initials: SH
authors.lastname: Yang
authors.forename: Song-ling
authors.initials: SL
authors.lastname: Wang
mesh_terms: D000818:Animals; D001284:Atrophy; D004195:Disease Models, Animal; D009055:Mouth / Q000382:microbiology*; D010306:Parotid Gland / Q000473:pathology*; D011897:Random Allocation; D012463:Saliva / Q000378:metabolism*; D013552:Swine; D013556:Swine, Miniature