title: [An autopsy specimen study of benign hyperplastic nodules in the peripheral zone of the prostate].
abstract: OBJECTIVE
  To investigate the correlation and anatomic association of benign hyperplastic nodules in the peripheral zone (PZ) with those in the transition zone (TZ) of the prostate, and to compare the histological components of the two kinds of nodules.
  
  
  METHODS
  We obtained benign hyperplastic nodules specimens from the PZ and TZ by autopsy, measured the distance between the outer surface of the nodules and the inner gland, observed the integrity of the surgical envelope of the prostate, and determined the histological components of the two kinds of nodules by HE staining, immunohistochemistry and automatic quantitative image analysis.
  
  
  RESULTS
  The surgical envelope of the prostate was integrated and the distance between the nodules of the PZ and the outer surface of the inner gland was about 2.5 to 5 mm ([3.9 +/- 0.8] mm), with no signs of anatomic connection in between. The stromata and epithelia in the nodules accounted for (69.32 +/- 8.35)% and (16.08 +/- 5.36)% in the PZ and (74.58 +/- 8.95)% and (15.82 +/- 6.41)% in the TZ.
  
  
  CONCLUSIONS
  Benign hyperplastic nodules may originate from the PZ of the prostate and not correlate with the inner gland hyperplasia in the TZ, but with no statistical difference between the histological components of the two kinds of nodules.
authors.affiliation: Department of Ultrasound, General Hospital of PLA, Beijing 100853, China. lxzc0819@163.com
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
authors.forename: Jing-Chun
authors.initials: JC
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Huai-Yin
authors.initials: HY
authors.lastname: Shi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D024042:Collagen Type I / Q000032:analysis; D024043:Collagen Type II / Q000032:analysis; D024061:Collagen Type III / Q000032:analysis; D024141:Collagen Type IV / Q000032:analysis; D005353:Fibronectins / Q000032:analysis; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D007797:Laminin / Q000032:analysis; D008297:Male; D011467:Prostate / Q000737:chemistry / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000378:metabolism / Q000473:pathology*
chemical_list: D024042:Collagen Type I; D024043:Collagen Type II; D024061:Collagen Type III; D024141:Collagen Type IV; D005353:Fibronectins; D007797:Laminin