Clinical correlation between dyslipidemia and pediatric chronic allograft nephropathy.
CAN refers to the progressive decline of renal function seen in some renal transplant recipients in association with alloantigen-dependent and alloantigen-independent factors. Hyperlipidemia is a known risk factor for cardiovascular disease and CAN in adult renal transplant recipients, whereas no data exist in the pediatric transplant population. In this cross-sectional study, 62 renal transplant recipients (32 CAN vs. 30 non-CAN) aged 5-18 yr and with the mean follow-up time of 48 months (9-93) after transplantation were evaluated for lipid profile and renal function tests. Hyperlipidemia has high prevalence in our patients both pre- and post-transplantation. Furthermore, hypercholesterolemia and high-LDL cholesterol levels have significant association with CAN (p = 0.019 and p = 0.039, respectively). In pediatric recipients, hyperlipidemia and particularly hypercholesterolemia have significant association with CAN and adults may need specific therapy.
Valavi
Ehsan
E
Jundishapoor University of Medical Sciences and Health Services, Ahvaz, Iran. dr_ehsan_valavi@yahoo.com
Otukesh
Hasan
H
Fereshtehnejad
Seyed-Mohammad
SM
Sharifian
Mostapha
M
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D008078:Cholesterol, LDL / Q000378:metabolism; D002908:Chronic Disease; D050171:Dyslipidemias / Q000150:complications* / Q000628:therapy*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000628:therapy; D006949:Hyperlipidemias / Q000150:complications / Q000628:therapy; D007674:Kidney Diseases / Q000473:pathology / Q000628:therapy*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D008297:Male; D012189:Retrospective Studies; D013997:Time Factors
D008078:Cholesterol, LDL