title: A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer.
abstract: To evaluate the tumour response to lomeguatrib and temozolomide (TMZ) administered for 5 consecutive days every 4 weeks in patients with metastatic colorectal carcinoma. Patients with stage IV metastatic colorectal carcinoma received lomeguatrib (40 mg) and TMZ (50-200 mg m(-2)) orally for 5 consecutive days every 4 weeks. Response was determined every two cycles. Pharmacokinetics of lomeguatrib and TMZ as well as their pharmacodynamic effects in peripheral blood mononuclear cells (PBMC) were determined. Nineteen patients received 49 cycles of treatments. Despite consistent depletion of O(6)-methylguanine-DNA methyltransferase in PBMC, none of the patients responded to treatment. Three patients had stable disease, one for the duration of the study, and no fall in carcinoembryonic antigen was observed in any patient. Median time to progression was 50 days. The commonest adverse effects were gastrointestinal and haematological and these were comparable to those of TMZ when given alone. This combination of lomeguatrib and TMZ is not efficacious in metastatic colorectal cancer. If further studies are to be performed, emerging data suggest that higher daily doses of lomeguatrib and a dosing period beyond that of TMZ should be evaluated.
authors.affiliation: CR UK Medical Oncology Unit, Churchill Hospital, Old Road, Oxford OX3 7LJ, UK.
authors.forename: O A
authors.initials: OA
authors.lastname: Khan
authors.forename: M
authors.initials: M
authors.lastname: Ranson
authors.forename: M
authors.initials: M
authors.lastname: Michael
authors.forename: I
authors.initials: I
authors.lastname: Olver
authors.forename: N C
authors.initials: NC
authors.lastname: Levitt
authors.forename: P
authors.initials: P
authors.lastname: Mortimer
authors.forename: A J
authors.initials: AJ
authors.lastname: Watson
authors.forename: G P
authors.initials: GP
authors.lastname: Margison
authors.forename: R
authors.initials: R
authors.lastname: Midgley
authors.forename: M R
authors.initials: MR
authors.lastname: Middleton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D003606:Dacarbazine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011687:Purines / Q000008:administration & dosage* / Q000009:adverse effects; D000077204:Temozolomide; D017211:Treatment Failure
chemical_list: D011687:Purines; D003606:Dacarbazine; C521206:lomeguatrib; D000077204:Temozolomide