P2 receptors in health and disease.
In the past ten years since the discovery and cloning of members of the P2 receptor family, rapid progress has been made in the field regarding the function and pharmacology of different P2 receptor subtypes. This research resulted in identifying these receptors as important players in the pathology of atherosclerosis, cystic fibrosis, neurodegenerative and autoimmune diseases, among other disorders. The signalling mechanisms whereby P2 receptors mediate pathogenesis are not clear in most cases. Future studies in this field will focus on the integration of signalling pathways coupled to P2 receptors and the generation of specific agonists/antagonists for each receptor subtype to provide strategies for the treatment of a variety of diseases.
Weisman
Gary A
GA
Department of Biochemistry, 540 Life Sciences Center, University of Missouri-Columbia, Columbia, MO 65211, USA. WeismanG@missouri.edu
Yu
Ningpu
N
Liao
Zhongji
Z
Gonzaléz
Fernando
F
Erb
Laurie
L
Seye
Cheikh I
CI
D000818:Animals; D002450:Cell Communication / Q000187:drug effects / Q000502:physiology; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology; D010336:Pathology / Q000639:trends; D058910:Purinergic P2 Receptor Agonists; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2 / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D058910:Purinergic P2 Receptor Agonists; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2