title: Mercaptoacetate inhibition of fatty acid beta-oxidation attenuates the oral acceptance of fat in BALB/c mice.
abstract: We investigated the effect of beta-oxidation inhibition on the fat ingestive behavior of BALB/c mice. Intraperitoneal administration to mice of mercaptoacetate, an inhibitor of fatty acid oxidation, significantly suppressed intake of corn oil but not intake of sucrose solution or laboratory chow. To further examine the effect of mercaptoacetate on the acceptability of corn oil in the oral cavity, we examined short-term licking behavior. Mercaptoacetate significantly and specifically decreased the number of licks of corn oil within a 60-s period but did not affect those of a sucrose solution, a monosodium glutamate solution, or mineral oil. In contrast, the administration of 2-deoxyglucose, an inhibitor of glucose metabolism, did not affect the intake or short-term licking counts of any of the tasted solutions. These findings suggest that fat metabolism is involved in the mechanism underlying the oral acceptance of fat as an energy source.
authors.affiliation: Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan. sigenobu@kais.kyoto-u.ac.jp
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Matsumura
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Saitou
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoneda
authors.forename: Takafumi
authors.initials: T
authors.lastname: Mizushige
authors.forename: Ai
authors.initials: A
authors.lastname: Eguchi
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Shibakusa
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Manabe
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tsuzuki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Inoue
authors.forename: Tohru
authors.initials: T
authors.lastname: Fushiki
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D003314:Corn Oil / Q000378:metabolism; D003847:Deoxyglucose / Q000494:pharmacology; D004041:Dietary Fats / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D005518:Food Preferences / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D063991:Mitochondrial Trifunctional Protein; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors*; D010084:Oxidation-Reduction; D013864:Thioglycolates / Q000494:pharmacology*
chemical_list: D004041:Dietary Fats; D009097:Multienzyme Complexes; D013864:Thioglycolates; D002245:Carbon Dioxide; C017487:2-mercaptoacetate; D003314:Corn Oil; D003847:Deoxyglucose; D063991:Mitochondrial Trifunctional Protein