title: Gender-specific association between polymorphism of vascular endothelial growth factor (VEGF 936 C>T) gene and colon cancer in Korea.
abstract: BACKGROUND
  Angiogenesis is an essential process in the development, growth and metastasis of malignant tumors such as colon cancer. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor. A case control study was carried out to determine whether there is an association between the VEGF 936C>T polymorphism and colon cancer.
  
  
  METHODS
  DNA samples taken from 262 colon cancer patients and 229 healthy controls were amplified by polymerase chain reaction for the VEGF 936C>T polymorphism.
  
  
  RESULTS
  Genotype frequencies of the VEGF 936C>T polymorphism were significantly different between patient and control groups (CT+TT, odds ratio(OR): 1.524, 95% confidence interval (CI): 1.033-2.249). When stratified by gender and age, the frequencies of the T allele-bearing genotypes significantly increased risk for colon cancer in women and patients younger than 55 years (in women, OR: 1.996, 95% CI: 1.151-3.464 and in <55 years, OR: 4.156, 95% CI: 1.885-9.163). In addition, this association remained in most cases with distal and proximal colon cancer.
  
  
  CONCLUSIONS
  Our study suggests that the VEGF 936C>T polymorphism might be a genetic determinant for colon cancer, at least in Koreans.
authors.affiliation: Institute for Clinical Research, College of Medicine, Pochon CHA University, Seongnam, South Korea.
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Bae
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Kim
authors.forename: Haeyoun
authors.initials: H
authors.lastname: Kang
authors.forename: Seong Gyu
authors.initials: SG
authors.lastname: Hwang
authors.forename: Doyeun
authors.initials: D
authors.lastname: Oh
authors.forename: Nam Keun
authors.initials: NK
authors.lastname: Kim
mesh_terms: D020413:3' Untranslated Regions; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000097:blood / Q000235:genetics*; D005260:Female; D005492:Folic Acid / Q000097:blood; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012737:Sex Factors; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; D042461:Vascular Endothelial Growth Factor A; D005492:Folic Acid