Photo-pH dually modulated fluorescence switch based on DNA spatial nanodevice.
In this paper, we describe our strategy on the design, construction, and characterization of a novel molecular device. By integrating a photoregulated fluorescent switch and a DNA-based nanomachine, the distance-dependent FRET process between fluorescein and photochromic moieties can be further modulated by the spatial output of a unique proton-driven DNA manomachine. This device could be reversibly switched in a reliable manner, and the fluorescence variation behavior, exhibited by this dually modulated fluorescence switch, can also mimic the function of a Boolean logic operation.
Liu
Huajie
H
National Centre for Nanoscience and Technology, Beijing, China.
Zhou
Yucheng
Y
Yang
Yang
Y
Wang
Wenxing
W
Qu
Li
L
Chen
Chen
C
Liu
Dongsheng
D
Zhang
Deqing
D
Zhu
Daoben
D
D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000528:radiation effects*; D006863:Hydrogen-Ion Concentration; D008027:Light; D015394:Molecular Structure; D036103:Nanotechnology / Q000379:methods*; D010777:Photochemistry
D005456:Fluorescent Dyes; D004247:DNA