title: Lobenzarit disodium inhibits the constitutive NO-cGMP metabolic pathways. Possible involvement as an immunomodulatory drug.
abstract: Lobenzarit disodtulIl (CCA) is a novel immunomodulatory drug useful in the treatment of chronic inflammations. Its principal mechanism of action seems to be through enhancing the T suppressor/T helper lymphocyte ratio. However, the molecular basis for these actions remains unclear. In this study it was found that CCA inhibits the production of guanosine 3',5'-cyclic monophosphate almost completely when present in concentrations of 1 mM. Further results demonstrated that such inhibition could also be explained by interference in constitutive nitric oxide generation. In addition to previous findings, more insight into the molecular mechanism of action of CCA is provided.
authors.affiliation: Center of Pharmaceutical Chemistry Department of Pharmacology and Toxicology Havana City POB 6990 Cuba.
authors.forename: J
authors.initials: J
authors.lastname: Padrón
authors.forename: A
authors.initials: A
authors.lastname: Rojas
authors.forename: L
authors.initials: L
authors.lastname: Glaría
authors.forename: L
authors.initials: L
authors.lastname: Caveda
authors.forename: R
authors.initials: R
authors.lastname: Delgado
authors.forename: M
authors.initials: M
authors.lastname: Torres
authors.forename: O
authors.initials: O
authors.lastname: Martínez
authors.forename: E
authors.initials: E
authors.lastname: López
authors.forename: A
authors.initials: A
authors.lastname: Beltrán
authors.forename: M
authors.initials: M
authors.lastname: Palacios