title: Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD.
abstract: An inverse relationship between arterial calcifications and bone activity has been documented in patients with ESRD. Calcium overload is associated with arterial calcification, which is associated with arterial stiffening. Whether bone activity interacts with calcium load, aortic stiffness, or arterial calcification is unknown. This study assessed the impact of bone activity on the relationships between the dosage of calcium-containing phosphate binders and aortic stiffness (measured by pulse wave velocity) or abdominal aorta calcification score. Aortic stiffness and calcification were both positively associated with calcium load and negatively associated with bone activity. A significant interaction was found between dosage of calcium-containing phosphate binders and bone activity such that calcium load had a significantly greater influence on aortic calcifications and stiffening in the presence of adynamic bone disease. Independent of any other factor, including dosage of calcium-containing phosphate binders, adynamic bone was associated with greater aortic stiffening, suggesting cross-talk between the bone and arterial walls.
authors.affiliation: Service de Néphrologie, Centre Hospitalier Manhès, Fleury Mérogis, France. glondon@club-internet.fr
authors.forename: Gérard M
authors.initials: GM
authors.lastname: London
authors.forename: Sylvain J
authors.initials: SJ
authors.lastname: Marchais
authors.forename: Alain P
authors.initials: AP
authors.lastname: Guérin
authors.forename: Pierre
authors.initials: P
authors.lastname: Boutouyrie
authors.forename: Fabien
authors.initials: F
authors.lastname: Métivier
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: de Vernejoul
mesh_terms: D000328:Adult; D001012:Aorta, Abdominal / Q000378:metabolism* / Q000503:physiopathology; D001842:Bone and Bones / Q000033:anatomy & histology / Q000378:metabolism*; D002114:Calcinosis / Q000378:metabolism*; D002118:Calcium / Q000008:administration & dosage / Q000378:metabolism*; D004548:Elasticity; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011674:Pulse; D006435:Renal Dialysis
chemical_list: D002118:Calcium