title: Cytotoxic Activity of Silyl- and Germyl-Substituted 4,4-Dioxo-3a,6a-Dihydrothieno[2,3-d]isoxazolines-2.
abstract: The [2+3] dipolar cycloaddition of nitrile oxides to the double C = C bonds of thiophene-1, 1-dioxides leads to formation of the fused isoxazolines-2 (1, 2). Tumor growth inhibition of these compounds strongly depends on the nature of group IV A element increasing from slightly active tert-butyl derivatives to silicon and germanium containing analogues. The products of benzonitrile oxide cycloaddition have greater cytotoxic effect than the compounds obtained from the cycloaddition reaction of 2, 5-disubstituted thiophene-1, 1-dioxides with acetonitrile oxide. Fused silyl substituted isoxazolines-2 are stronger NO-inducers than their germyl and tert-butyl analogues.
authors.affiliation: Latvian Institute of Organic Synthesis Aizkraukles 21 Riga LV-1006 Latvia.
authors.forename: E
authors.initials: E
authors.lastname: Lukevics
authors.forename: P
authors.initials: P
authors.lastname: Arsenyan
authors.forename: I
authors.initials: I
authors.lastname: Shestakova
authors.forename: O
authors.initials: O
authors.lastname: Zharkova
authors.forename: I
authors.initials: I
authors.lastname: Kanepe
authors.forename: R
authors.initials: R
authors.lastname: Mezapuke
authors.forename: O
authors.initials: O
authors.lastname: Pudova