Lipoprotein charge and vascular lipid metabolism.
Lipoproteins play a central role in transporting hydrophobic molecules through the bloodstream and between specific tissues. Lipoprotein molecules have a distinctive electrical charge and changes in electrostatic properties directly affect the metabolism of the lipoprotein. Lipoprotein charge controls interfacial interactions and determines the ability of the lipoprotein to interact with intravascular enzymes and cell surface proteins. Uniquely charged constituents of the lipoprotein thereby control the metabolism of lipoproteins by creating a regulatory system wherein the electrostatic properties of plasma lipoproteins determine the fate of intravascular lipids.
Sparks
Daniel L
DL
Lipoprotein and Atherosclerosis Research Group, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7. dsparks@ottawaheart.ca
Chatterjee
Cynthia
C
Young
Elizabeth
E
Renwick
Joanna
J
Pandey
Nihar R
NR
D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D050171:Dyslipidemias / Q000378:metabolism / Q000473:pathology; D004730:Endothelium, Vascular / Q000737:chemistry / Q000201:enzymology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D050356:Lipid Metabolism / Q000502:physiology*; D008074:Lipoproteins / Q000097:blood* / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D055672:Static Electricity; D014280:Triglycerides / Q000097:blood / Q000737:chemistry
D008074:Lipoproteins; D008565:Membrane Proteins; D014280:Triglycerides