title: Free-radical-scavenging principles from Phlomis caucasica.
abstract: Seven free-radical-scavenging phenolic compounds including five flavonoids, rutin (1), chrysoeriol 7-O-rutinoside (2), kaempferol 3-O-glucoside (3), chrysoeriol 7-O-glucoside (4) and naringenin (5), and two phenylethanoid glycosides, forsythoside B (6) and acteoside (7) were isolated from the methanol extract of the aerial parts of the Iranian medicinal plant Phlomis caucasica by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated by spectroscopic means. The free-radical-scavenging properties of 1-7 were assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay. Among these compounds, forsythoside B (6) and acteoside (7) were found to be the most potent antioxidants with the RC(50) values of 4.97 and 4.27 microg/ml, respectively.
authors.affiliation: School of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Delazar
authors.forename: Araz
authors.initials: A
authors.lastname: Sabzevari
authors.forename: Mahdi
authors.initials: M
authors.lastname: Mojarrab
authors.forename: Hossein
authors.initials: H
authors.lastname: Nazemiyeh
authors.forename: Solmaz
authors.initials: S
authors.lastname: Esnaashari
authors.forename: Lutfun
authors.initials: L
authors.lastname: Nahar
authors.forename: Seied Mehdi
authors.initials: SM
authors.lastname: Razavi
authors.forename: Satyajit Dey
authors.initials: SD
authors.lastname: Sarker
mesh_terms: D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds; D002851:Chromatography, High Pressure Liquid; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D007492:Iran; D008519:Medicine, Traditional; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D031345:Phlomis / Q000737:chemistry*; D010851:Picrates; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D005419:Flavonoids; D016166:Free Radical Scavengers; D006027:Glycosides; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl