Metabolism of hibernating myocardium assessed by microdialysis during surgical revascularization: report of a case.
We present an 80-year-old woman with hibernating myocardium in the left anterior descending coronary artery (LAD) territory who underwent surgical revascularization and metabolic evaluation of the dysfunctioning segments by microdialysis (microD) technique. Myocardial lactate, pyruvate, and glucose did not show obvious changes throughout the procedure. Conversely, myocardial glycerol and glutamate concentrations markedly increased early after cardioplegic arrest and subsided after weaning from cardiopulmonary bypass (CPB) and recovery of myocardial function. Intraoperative myocardial microD may add relevant pathophysiologic information on hibernating myocardium undergoing coronary flow restoration and, eventually, improve patient care.
Mazzoni
Maurizio
M
Department of Anesthesia and Intensive Care, Humanitas Gavazzeni, Bergamo, Lombardy, Italy.
Bortone
Franco
F
Ceriani
Roberto
R
Caprioli
Giuseppe
G
Passaretti
Bruno
B
Arena
Vincenzo
V
Parodi
Oberdan
O
D000369:Aged, 80 and over; D002315:Cardiopulmonary Bypass; D005260:Female; D006324:Heart Arrest, Induced; D006801:Humans; D017551:Microdialysis; D016343:Monitoring, Intraoperative; D009204:Myocardial Revascularization; D017682:Myocardial Stunning / Q000378:metabolism* / Q000601:surgery; D009206:Myocardium / Q000378:metabolism*