title: One hundred times the intended dose of caudal clonidine in three pediatric patients.
abstract: We report three sequential cases in which children received 100 times the intended dose of clonidine in their single shot caudals. Although all experienced excessive somnolence for up to 24 h, none had respiratory depression, oxygen desaturation, supplemental oxygen requirement, or hemodynamic instability. These cases suggest a large margin of safety exists for caudally administered clonidine in healthy children.
authors.affiliation: University of Wisconsin School of Medicine and Public Health, Clinical Science Center, Madison, WI 53792-3272, USA. cmeyer@wisc.edu
authors.forename: Cari
authors.initials: C
authors.lastname: Meyer
authors.forename: Rachel
authors.initials: R
authors.lastname: Cambray
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage* / Q000009:adverse effects; D000763:Anesthesia, Caudal / Q000379:methods*; D002675:Child, Preschool; D003000:Clonidine / Q000008:administration & dosage* / Q000009:adverse effects; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008508:Medication Errors; D016896:Treatment Outcome
chemical_list: D000316:Adrenergic alpha-Agonists; D003000:Clonidine