title: 3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: a class of potent DPP-4 inhibitors.
abstract: Systematic variations of the xanthine scaffold in close analogs of development compound BI 1356 led to the class of 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones which provided, after substituent screening, a series of highly potent DPP-4 inhibitors.
authors.affiliation: Department of Chemical Research, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach, Germany. matthias.eckhardt@boehringer-ingelheim.com
authors.forename: Matthias
authors.initials: M
authors.lastname: Eckhardt
authors.forename: Norbert
authors.initials: N
authors.lastname: Hauel
authors.forename: Frank
authors.initials: F
authors.lastname: Himmelsbach
authors.forename: Elke
authors.initials: E
authors.lastname: Langkopf
authors.forename: Herbert
authors.initials: H
authors.lastname: Nar
authors.forename: Michael
authors.initials: M
authors.lastname: Mark
authors.forename: Moh
authors.initials: M
authors.lastname: Tadayyon
authors.forename: Leo
authors.initials: L
authors.lastname: Thomas
authors.forename: Brian
authors.initials: B
authors.lastname: Guth
authors.forename: Ralf
authors.initials: R
authors.lastname: Lotz
mesh_terms: D020650:Combinatorial Chemistry Techniques; D054873:Dipeptidyl-Peptidase IV Inhibitors; D006801:Humans; D000069476:Linagliptin; D015394:Molecular Structure; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D011687:Purines; D011724:Pyridazines; D011799:Quinazolines; D000069476:Linagliptin