title: [Anaesthesia of the myasthenic patients during thymectomy].
abstract: Myasthenia is a rare autoimmune disease characterized by fluctuating muscle weakness and fatigability due to a reduction in available acetylcholine receptors at the neuromuscular junction. Data of 186 patients suffering from myasthenia were collected retrospectively. All patients underwent thymectomy over a 23 years period from 1981 to 2006 without surgical mortality. Postoperative ventilation was required for more than 24 hours in seven patients and one patient needed postoperative ventilatory support more than seven days. Thymectomy for myasthenia was performed using promethazine and atropine in general anaesthesia. Introduction could be facilitated with propofol, etomidate or thiopental and sevoflurane, avoiding use of any muscle relaxants. Non-depolarizing muscle relaxants were not used during the procedures. Adequate surgical conditions were provided by short-acting inhaled anaesthetics (sevoflurane) and small doses of opiates. 95% of the narcotized patients were immediately extubated after the procedure in the operating room. Length of stay in intensive care unit could have been reduced without any postoperative ventilatory support. Nonsteroid analgesics and nalbuphine were used for pain relief. Anaesthesia of thymectomy is based on volatile gases. Airway complications can be prevented with use of small amounts of anticholinergic drugs, perhaps steroids.
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Aneszteziológiai és Intenzív Terápiás Tanszék, Debrecen. hallay@dote.hu
authors.forename: Judit
authors.initials: J
authors.lastname: Hallay
authors.forename: Csaba
authors.initials: C
authors.lastname: Micskei
authors.forename: Sándor
authors.initials: S
authors.lastname: Kollár
authors.forename: Sándor
authors.initials: S
authors.lastname: Sz Kiss
authors.forename: Béla
authors.initials: B
authors.lastname: Fülesdi
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage; D000328:Adult; D000368:Aged; D000768:Anesthesia, General / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D004576:Electromyography; D005260:Female; D006801:Humans; D006814:Hungary; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000175:diagnosis / Q000503:physiopathology; D012189:Retrospective Studies; D013934:Thymectomy
chemical_list: D000759:Adjuvants, Anesthesia; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives