Cytokine gene regulation by PGE(2), LTB(4) and PAF.
The initial response of the host to noxious stimuli produces a nonspecific inflammatory response. A more specific immune response is believed to be modulated by two classes of molecules: lipid mediators (PG, LT and PAF) and cytokines, synthesized by phagocytes and parenchyreal cells. In this review we discuss the increasing evidence of the interrelationship between eicosanoids, PAF and cytokines: IL-1 and TNF induce PG synthesis in various cells and PG, in turn, modulate cytokine production. We focused on the regulatory effects of LTB(4), PGE(2) and PAF on cytokine gene expression.
Rola-Pleszczynski
M
M
Immunology Division Department of Pediatrics Faculty of Medicine University of Sherbrooke Sherbrooke QC J1H 5N4 Canada.
Stankova
J
J