[Significance of glomerular filtration rate in evaluating renal function of comparative study of methods thereof].
OBJECTIVE
To evaluate the applicability of the Cockcroft-Gault equation and the abbreviated Modification of diet in Renal Disease (MDRD) study equation to estimate the renal function of diabetic patients.


METHODS
Glomerular filtration rates measured by these two equations were compared with the value of GFR measured by 99Tc(m)-DTPA dynamic renal Imaging (considered as gold standard), to determine which equation is more appropriate in the subjects with diabetes.


RESULTS
Both of the results of the two equations deviated from the GFR measured by 99Tc(m)-DTPA dynamic renal Imaging: the GFRCG result was lower and the GFR(MDRD) result was higher than the real GFR value. However, the correlation analysis, coherence testing, and accuracy by receiver operating characteristic curve analysis showed that the coefficient of correlation, coherence rate, and accuracy of the GFR(MDRD) formula with the gold standard were all higher than those of the GFR(CG) formula.


CONCLUSIONS
The abbreviated style of MDRD equation is more appropriate than Cockcroft-Gault equation for the estimating of renal function in diabetic patients.
Wang
Wen-xi
WX
Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology, Metabolism of Shanghai Jiaotong University Affiliated Sixth Peoples Hospital, Shanghai 200233, China.
Jia
Wei-ping
WP
Bao
Yu-qian
YQ
Li
Qing
Q
Lu
Hui-juan
HJ
Xiang
Kun-san
KS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016284:Technetium Tc 99m Pentetate
D016284:Technetium Tc 99m Pentetate