title: [Toxic megacolon secondary to Clostridium difficile-associated pseudomembranous colitis].
abstract: A 78-year-old male without pre-existing comorbidity who underwent revision of a hip arthroplasty developed abdominal pain and distension, diarrhoeas, pyrexia and leucocytosis after only 5 days' postoperative treatment with cefuroxime and gentamycine. Abdominal computed tomography demonstrated severe colonic dilation, inflammation and oedema consistent with toxic megacolon. Stool samples were positive for Clostridium difficile. Oral vancomycine treatment and colonic decompression were inefficient. Subtotal colectomy was performed after which the condition improved.
authors.affiliation: Arhus Universitetshospital, Arhus Sygehus, Kirurgisk Afdeling P. torstenbr@dadlnet.dk
authors.forename: Torsten Bloch
authors.initials: TB
authors.lastname: Rasmussen
authors.forename: Mikkel Lønborg
authors.initials: ML
authors.lastname: Friis
authors.forename: Rudolf
authors.initials: R
authors.lastname: Lehnhoff
authors.forename: Anders
authors.initials: A
authors.lastname: Tøttrup
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019644:Arthroplasty, Replacement, Hip; D002444:Cefuroxime / Q000008:administration & dosage; D003082:Colectomy; D003937:Diagnosis, Differential; D004761:Enterocolitis, Pseudomembranous / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008532:Megacolon, Toxic / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology / Q000601:surgery; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002444:Cefuroxime