title: Type 1 interferons cool the inflamed brain.
abstract: Although interferon-beta is the most popular treatment for multiple sclerosis, its mechanism of action remains enigmatic. In this issue of Immunity, Prinz et al. (2008) elucidate an intriguing portrait of the pleiotropic effects of type 1 interferons in taming brain inflammation.
authors.affiliation: Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Axtell
authors.forename: Lawrence
authors.initials: L
authors.lastname: Steinman
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D001921:Brain / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D006801:Humans; D016899:Interferon-beta / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D017628:Microglia / Q000276:immunology / Q000378:metabolism; D009103:Multiple Sclerosis / Q000276:immunology / Q000378:metabolism; D009186:Myelin Sheath / Q000276:immunology; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism; D010587:Phagocytosis; D053633:Receptor, Interferon alpha-beta / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D015854:Up-Regulation
chemical_list: D016207:Cytokines; D000949:Histocompatibility Antigens Class II; D053633:Receptor, Interferon alpha-beta; D016899:Interferon-beta