title: [Chaperon-like anticataract agents, the antiaggregants of lens crystallin. Communication 4. Study of the effect of a mixture of di- and tetrapeptides on a prolonged rat model of UV-induced cataract].
abstract: There is a potential of therapeutic action on certain stages of caractogenesis, in particular on the aggregation of water-soluble proteins of cytoplasmic lens fiber cells, giving rise to insoluble protein complexes. The effect of a combined preparation (N-acetyl carnosine and D-patethine), acting by the chaperon-like mechanism, was studied in vivo on a prolonged rat model of UV-induced cataract. The use of the combined preparation consisting of a mixture of peptides of N-acetyl carnosine and D-patethine in a ratio of 1:1 as ocular instillations and intraperitoneal injections could slow down the development of UV-induced cataract in vivo. Pathomorphological studies suggest that the combined preparation has a protective effect on lens tissue when the rat model of UV-induced cataract is employed.
authors.forename: S E
authors.initials: SE
authors.lastname: Avetisov
authors.forename: G S
authors.initials: GS
authors.lastname: Polunin
authors.forename: N L
authors.initials: NL
authors.lastname: Sheremet
authors.forename: I A
authors.initials: IA
authors.lastname: Makarov
authors.forename: A A
authors.initials: AA
authors.lastname: Fedorov
authors.forename: O E
authors.initials: OE
authors.lastname: Karpova
authors.forename: K O
authors.initials: KO
authors.lastname: Muranov
authors.forename: A K
authors.initials: AK
authors.lastname: Dizhevskaia
authors.forename: L V
authors.initials: LV
authors.lastname: Soustov
authors.forename: E V
authors.initials: EV
authors.lastname: Chelnokov
authors.forename: N M
authors.initials: NM
authors.lastname: Bitiurin
authors.forename: N V
authors.initials: NV
authors.lastname: Sapogova
authors.forename: V V
authors.initials: VV
authors.lastname: Nemov
authors.forename: A A
authors.initials: AA
authors.lastname: Bodyrev
authors.forename: M A
authors.initials: MA
authors.lastname: Ostrovskiĭ
mesh_terms: D000818:Animals; D002336:Carnosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002386:Cataract / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D003459:Crystallins / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D004195:Disease Models, Animal; D018450:Disease Progression; D005500:Follow-Up Studies; D007908:Lens, Crystalline / Q000378:metabolism* / Q000473:pathology / Q000528:radiation effects; D008297:Male; D018832:Molecular Chaperones / Q000627:therapeutic use*; D009842:Oligopeptides / Q000627:therapeutic use; D011379:Prognosis; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D003459:Crystallins; D018832:Molecular Chaperones; D009842:Oligopeptides; C033681:N-acetylcarnosine; D002336:Carnosine