NOX enzymes and Toll-like receptor signaling.
Invading microorganisms are recognized by the host innate immune system through pattern recognition receptors. Among these receptors, Toll-like receptors (TLRs) are able to sense the molecular signatures of microbial pathogens, protozoa, fungi, and virus and activate proinflammatory signaling cascades. In addition to their role in bacterial killing by phagocytes, reactive oxygen species generated by NADPH oxidase (NOX) homologues also play key roles in signaling and host defense in a variety of cell types. Recent studies have demonstrated a link between TLR activation and NOX homologues following microbial recognition highlighting their important role in the innate immune response and host defense.
Ogier-Denis
Eric
E
INSERM, U773, Centre de Recherche Biomédicale Bichat Beaujon, CRB3, BP 416, 75018 Paris, France. ogier@bichat.inserm.fr
Mkaddem
Sanae Ben
SB
Vandewalle
Alain
A
D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D019255:NADPH Oxidases / Q000276:immunology* / Q000378:metabolism; D051193:Toll-Like Receptors / Q000276:immunology* / Q000378:metabolism
D051193:Toll-Like Receptors; D019255:NADPH Oxidases