Whole liver versus split liver versus living donor in the adult recipient: an analysis of outcomes by graft type.
BACKGROUND
We studied patient and graft survival rates in adult liver transplant recipients, analyzing outcomes based on donor source (deceased donor [DD] vs. living donor [LD]) and graft type (whole liver vs. partial liver).


METHODS
A retrospective database analysis of all adult liver transpants performed at our center over a 7-year period of time.


RESULTS
Between 1999 and 2005, 384 liver transplants were performed in adult recipients, either as a whole liver from a deceased donor (DD-WL, n=284), split liver from a DD (DD-SL, n=31), or a partial transplant from a living donor (LD, n=69). DD-SL transplants were performed with a full right or left lobe graft, while LD transplants used the right lobe. Demographic differences in the three groups were most noticeable for lower model for end-stage liver disease scores in LD recipients (P<0.001) and younger donor age in DD-SL recipients (P<0.001). Superior graft survival results were seen in LD recipients versus either DD-WL recipients or DD-SL recipients (P=0.02 and P=0.05, respectively). Multivariate analysis showed hepatitis C (HR=1.53, P=0.05) and hepatocellular carcinoma (HR=1.74, P=0.03) to be significant risk factors for patient survival. Hepatitis C (HR=1.61, P=0.03) and donor age more than 50 (HR=1.64, P=0.04) were significant risk factors for graft survival. However, neither graft type nor donor source were significant independent risk factors for patient or graft survival.


CONCLUSIONS
Our data suggests that the status of the recipient is probably a more important determinant of outcome than graft type or donor source.
Humar
Abhinav
A
Department of Surgery, University of Minnesota, Minneapolis, MN, USA. humar001@umn.edu
Beissel
Joy
J
Crotteau
Shaina
S
Kandaswamy
Raja
R
Lake
John
J
Payne
William
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002102:Cadaver; D002423:Cause of Death; D005260:Female; D006085:Graft Survival / Q000502:physiology*; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D016031:Liver Transplantation / Q000276:immunology / Q000401:mortality / Q000502:physiology / Q000706:statistics & numerical data*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods; D011183:Postoperative Complications / Q000145:classification; D014019:Tissue Donors; D020858:Tissue and Organ Harvesting / Q000379:methods*; D016896:Treatment Outcome