title: Modular asymmetric synthesis of P-chirogenic beta-amino phosphine boranes.
abstract: A short concise route to beta-aminophosphine boranes is presented via the desymmetrization of prochiral phosphine boranes, forming P-chirogenic aldehydes that are rapidly transformed to the target compounds employing reductive amination under microwave irradiation. This sequence provides a modular route to P-chirogenic P,N ligands, and in addition, the intermediate aldehydes are versatile P-chiral building blocks for ligand design in general. An alternative pathway via the corresponding alpha-carboxyphosphines is also described. The ligands were subsequently evalutated in the asymmetric conjugate addition of diethylzinc to trans-beta-nitrostyrene.
authors.affiliation: Organic Chemistry, Department of Chemical and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden. magjo@chembio.chalmers.se
authors.forename: Magnus J
authors.initials: MJ
authors.lastname: Johansson
authors.forename: Kristian H O
authors.initials: KH
authors.lastname: Andersson
authors.forename: Nina
authors.initials: N
authors.lastname: Kann