Granular parakeratosis in a patient treated with liposomal doxorubicin for ovarian carcinoma.
Granular parakeratosis is a rare benign dermatosis caused by an acquired disorder of keratinization that usually manifests with reddish-brown keratotic papules and plaques in intertriginous areas. It has specific histologic features but its pathogenesis remains unclear. Its frequency is probably underestimated because the condition is usually misdiagnosed as simple intertrigo. We report herein a new case of granular parakeratosis in a woman treated with liposomal doxorubicin for ovarian carcinoma that showed complete remission after discontinuation of chemotherapy. The relationship between granular parakeratosis and chemotherapy is discussed.
Jaconelli
Laure
L
Department of Dermatology, Edouard Herriot Hospital, Lyon, France.
Doebelin
Bénédicte
B
Kanitakis
Jean
J
Saïd
Benoît Ben
BB
Faure
Michel
M
Claudy
Alain
A
D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D004317:Doxorubicin / Q000009:adverse effects / Q000031:analogs & derivatives*; D004817:Epidermis / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D010241:Parakeratosis / Q000139:chemically induced* / Q000473:pathology; D011092:Polyethylene Glycols / Q000009:adverse effects*
D000903:Antibiotics, Antineoplastic; C506643:liposomal doxorubicin; D011092:Polyethylene Glycols; D004317:Doxorubicin