Roles of TRAF molecules in B lymphocyte function.
Tumor necrosis factor receptor associated factors (TRAFs) play a variety of interesting and important roles in the regulation of B lymphocyte function. They act both as cytoplasmic regulatory molecules, and as signal transducers for receptors involved in both innate and adaptive humoral immune responses. In this brief review, we highlight the current state of knowledge of the diverse roles of TRAF molecules in the functions of B lymphocytes.
Xie
Ping
P
Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA.
Kraus
Zachary J
ZJ
Stunz
Laura L
LL
Bishop
Gail A
GA
D000818:Animals; D053265:B-Cell Activation Factor Receptor / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D017730:Ki-1 Antigen / Q000378:metabolism; D051379:Mice; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D051193:Toll-Like Receptors / Q000378:metabolism; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000378:metabolism; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000378:metabolism; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Q000502:physiology*; D014763:Viral Matrix Proteins / Q000378:metabolism
D053265:B-Cell Activation Factor Receptor; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D017730:Ki-1 Antigen; D018124:Receptors, Tumor Necrosis Factor; D051193:Toll-Like Receptors; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; D014763:Viral Matrix Proteins