Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. Synthesis, Characterization and In Vitro Cytostatic Assays.
The synthesis, characterization and biological assays of two new rhodium carboxylate sugar derivatives and respective cyclosphosphamide adducts are described. The compounds, characterized by (13)C and (1)H NMR, infrared and UV-visible spectra, presented high water solubility and hydration grades were confirmed given the concordance between thermal and CHN analyses. The adducts were active in vitro against K-562 cells.
Gil
E de S
Ede S
Faculty of Pharmaceutical Sciences University of São Paulo SP 05389-970 Brazil.
Gonçalves
M I
MI
Ferreira
E I
EI
Zyngier
S B
SB
Najjar
R
R