title: Cytotoxic activities of trichothecenes isolated from an endophytic fungus belonging to order Hypocreales.
abstract: Bioassay-guided fractionation of the extract of the endophytic fungus KLAR 5 belonging to order Hypocreales, which was isolated from the twig of Knema laurina (Blume) Warb., resulted in the isolation of brefeldin A (1), 8-deoxy-trichothecin (2), trichothecolone (3), 7alpha-hydroxytrichodermol (4), and 7alpha-hydroxyscirpene (5). Compound 5 was isolated from natural source for the first time. Compound 1 was very highly active against human epidermoid carcinoma of the mouth, human breast cancer (BC-1), and human small cell lung cancer (NCI-H187) cells whereas compounds 2 and 4 were selectively active against BC-1 and NCI-H187 cells. Compounds 3 and 5 were moderately active against these three cancer cell lines.
authors.affiliation: Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand. maneekarn@swu.ac.th
authors.forename: Maneekarn
authors.initials: M
authors.lastname: Chinworrungsee
authors.forename: Suthep
authors.initials: S
authors.lastname: Wiyakrutta
authors.forename: Nongluksna
authors.initials: N
authors.lastname: Sriubolmas
authors.forename: Phitaya
authors.initials: P
authors.lastname: Chuailua
authors.forename: Apichart
authors.initials: A
authors.lastname: Suksamrarn
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006999:Hypocreales; D026324:Myristicaceae / Q000382:microbiology*; D014255:Trichothecenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D014255:Trichothecenes