title: The effect of lipocortin 1 on neutrophil deformability.
abstract: Lipocortn 1 (Lc1) is an anti-inflammatory protein, which, given systemically, inhibits polymorphonuclear neutrophil (PMN) emigration from the circulation to sites of inflammation; delivery of Lc1 to the inflamed site is ineffective. We have examined the effect of Lc1 on changes in PMN deformability, and observed a consistent improvement in the deformability of unstimulated PMN; N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated cell deformability was unaltered. A Lc1-induced increase in cell deformability may reduce PMN sequestration so contributing to the anti-migratory effects of systemic Lc1 previously demonstrated in vivo.
authors.affiliation: Department of Medicine Rayne Laboratory University of Edinburgh Medical School, Teviot Place Edinburgh EH8 9AG UK.
authors.forename: E M
authors.initials: EM
authors.lastname: Drost
authors.forename: W
authors.initials: W
authors.lastname: Macnee
authors.forename: S F
authors.initials: SF
authors.lastname: Smith