title: A case of HIV co-infected with hepatitis B virus precore/core deletion mutant treated by entecavir.
abstract: We report a case of a HIV and hepatitis B virus (HBV)-co-infected patient to whom entecavir (ETV) was administered initially before the notification regarding the potential mutagenesis effect on HIV against the nucleoside analog. Since initial evaluations indicated the advanced stage of chronic hepatitis B and preserved numbers of peripheral CD4+ lymphocytes without the manifestation of immunodeficiency, priority was given to the management of HBV. We started HBV therapy with ETV at a dose of 0.5 mg daily without using any HIV drugs. The viral loads of both HBV and HIV-1 decreased gradually during the 5 months following the initial administration of ETV. HBV was well controlled by the gradual replacement of ETV with highly-active antiretroviral therapy against HIV with a regimen including atazanavir, emtricitabine, and tenofovir. HBV was genotyped as A2 with the quasispecies pool consisting of the -1G precore/core deletion mutant strain.
authors.affiliation: Department of Internal Medicine, Tohoku University Hospital, Sendai, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Fukushima
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
authors.forename: Jun
authors.initials: J
authors.lastname: Inoue
authors.forename: Yuta
authors.initials: Y
authors.lastname: Wakui
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Obara
authors.forename: Osamu
authors.initials: O
authors.lastname: Kimura
authors.forename: Osamu
authors.initials: O
authors.lastname: Kido
authors.forename: Yu
authors.initials: Y
authors.lastname: Nakagome
authors.forename: Eiji
authors.initials: E
authors.lastname: Kakazu
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kogure
authors.forename: Yasuteru
authors.initials: Y
authors.lastname: Kondo
authors.forename: Futoshi
authors.initials: F
authors.lastname: Nagasaki
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yamagiwa
authors.forename: Yugo
authors.initials: Y
authors.lastname: Ashino
authors.forename: Tooru
authors.initials: T
authors.lastname: Shimosegawa