Antioxidant 2-phenylbenzofurans and a coumestan from Lespedeza virgata.
Two 2-phenylbenzofurans, lespedezavirgatol (1) and lespedezavirgatal (2), and a coumestan, lespedezacoumestan (3), were isolated from the aerial parts of Lespedeza virgata, together with nine known flavonoids. Their structures were determined on the basis of spectroscopic data. The three new compounds showed strong oxygen radical absorbance capacity and potent inhibition toward lipid peroxidation in both plasma and kidney homogenate of renal failure rats.
Chen
Yan
Y
Department of Pharmacology, School of Traditional Chinese Medicine, Southern Medical UniVersity, Guangzhou 510515, People's Republic of China.
Wei
Xiaoyi
X
Xie
Haihui
H
Deng
Hongzhu
H
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D029884:Lespedeza / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D000975:Antioxidants; D001572:Benzofurans; D003374:Coumarins; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C530687:lespedezacoumestan; C530686:lespedezavirgatal; C530685:lespedezavirgatol; C505898:coumestan; D001205:Ascorbic Acid