Pathogenic role of antiphospholipid antibodies.
The antiphospholipid antibody syndrome (APS) is characterized by recurrent arterial and venous thrombosis and/or pregnancy in association with antiphospholipid (aPL) antibodies. The pathogenic mechanisms in APS that lead to in vivo injury are incompletely understood. Recent evidence suggests that APL antibodies alter regulation of haemostasis and induce activation of complement. We will discuss the current knowledge on how aPL antibodies trigger increased inflammation and enhanced thrombotic tendency, and thereby lead to tissue damage.
Salmon
J E
JE
Department of Medicine, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York 10021, USA. salmonj@hss.edu
de Groot
P G
PG
D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D000938:Antigen-Presenting Cells / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D006487:Hemostasis / Q000276:immunology; D006801:Humans; D019851:Thrombophilia / Q000276:immunology / Q000473:pathology
D017152:Antibodies, Antiphospholipid; D003165:Complement System Proteins