title: [A case of primary lung adenocarcinoma accompanied by Ewing's sarcoma successfully treated with ifosfamide].
abstract: We report a patient with primary lung adenocarcinoma who had Ewing's sarcoma and was successfully treated with ifosfamide. A 56-year-old Japanese man was referred to the Orthopedic Department of our hospital with a complaint of pain on his hip, ischuria, and dyschezia (vesicorectal disorder). MRI showed a mass in the sacrum. Open biopsy revealed Ewing's sarcoma (T2N0M0G4, Stage II B). Chest CT to screen showed an abnormal shadow in the left pulmonary lower lobe (S10). Bronchoscopic examination revealed primary lung adenocarcinoma(cT2N0M0, Stage I B). Because of a severe hip pain, treatment for Ewing's sarcoma by high-dose ifosfamide (day 1: 4 g/m2/day --> day 2-7: 2 g/m2/day: total 14 g/m2) was given in one course before lung surgery. The lung adenocarcinoma became small, the reduction ratio of the tumor was 26.5% and the tumor changed into a cavity. No serious adverse effect was observed.
authors.affiliation: Dept. of General Surgery, Yokohama City University School of Medicine.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Arai
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Rino
authors.forename: Sumitaka
authors.initials: S
authors.lastname: Yamanaka
authors.forename: Norio
authors.initials: N
authors.lastname: Yukawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Wada
authors.forename: Makoto
authors.initials: M
authors.lastname: Kudo
authors.forename: Yuuji
authors.initials: Y
authors.lastname: Watanuki
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Fukumura
authors.forename: Kuniharu
authors.initials: K
authors.lastname: Nakajima
authors.forename: Hisashi
authors.initials: H
authors.lastname: Oshiro
authors.forename: Shoji
authors.initials: S
authors.lastname: Yamanaka
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy*; D012512:Sarcoma, Ewing / Q000188:drug therapy*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide