Taking a toll road to better vaccines.
Effective subunit vaccines must elicit strong CD4(+) T cell responses. In this issue of Immunity, Malherbe et al. (2008) find that the ability of adjuvants to stimulate high-avidity T cell responses correlates with Toll-like-receptor engagement.
Morley
Sharon Celeste
SC
Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, USA.
Allen
Paul M
PM
D000276:Adjuvants, Immunologic; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D045304:Cytochromes c / Q000276:immunology*; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism*; D014612:Vaccines / Q000276:immunology*; D022223:Vaccines, Subunit / Q000276:immunology
D000276:Adjuvants, Immunologic; D011948:Receptors, Antigen, T-Cell; D051193:Toll-Like Receptors; D014612:Vaccines; D022223:Vaccines, Subunit; D045304:Cytochromes c