Regulation of gene expression by the RNA-binding protein Sam68 in cancer.
Sam68 (Src-associated in mitosis 68 kDa) is the prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. Sam68 is implicated in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the present review, we summarize the functions of Sam68 as a transcriptional and post-transcriptional regulator of gene expression, with particular relevance to cancer.
Rajan
Prabhakar
P
Institute of Human Genetics, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK. prabs_rajan@yahoo.co.uk
Gaughan
Luke
L
Dalgliesh
Caroline
C
El-Sherif
Amira
A
Robson
Craig N
CN
Leung
Hing Y
HY
Elliott
David J
DJ
D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D012323:RNA Processing, Post-Transcriptional; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic
D016601:RNA-Binding Proteins