title: In Vitro and In Vivo Behaviour of In Complexes of TTHA, TTHA-Bis(Butylamide) and TTHA-Bis(Glucamide): Stability, Biodistribution and Excretion Studied by Gamma Imaging.
abstract: Aiming at radiopharmaceutical application, (111)In(3+) complexes of the polyaminocarboxylates TTHA, TTHA-bis(butylamide) and TTHA-bis(glucamide) were investigated. The in vitro stability of (111)In(TTHA)(3-) and (111)In(TTHA-bis(butylamide)(-) was evaluated by measuring the exchange of (111)In(3+) from the complexes to transferrin and the results were compared with those for (111)In(DTPA)(2-). We also performed biodistribution studies of the three (111)In(3+) complexes by gamma-imaging in Wistar rats and by measuring the radioactivity in their organs. TTHA and its derivatives seem to have similar in vivo biodistribution with prevailing renal excretion.
authors.affiliation: Serviço de Biofísica e Biomatemática Fac. Medicina Univ. de Coimbra Portugal.
authors.forename: M I
authors.initials: MI
authors.lastname: Prata
authors.forename: M J
authors.initials: MJ
authors.lastname: Ribeiro
authors.forename: A C
authors.initials: AC
authors.lastname: Santos
authors.forename: J A
authors.initials: JA
authors.lastname: Peters
authors.forename: F
authors.initials: F
authors.lastname: Nepveu
authors.forename: C F
authors.initials: CF
authors.lastname: Geraldes
authors.forename: J J
authors.initials: JJ
authors.lastname: de Lima