Thymoma and thymic carcinoma arising in a thymolipoma: report of a unique case.
Thymic carcinoma arising within a thymolipoma has not been reported previously. The authors present a unique case of thymoma and undifferentiated thymic carcinoma arising within a thymolipoma in a 36-year-old woman. The bulk of the resected mass was composed of benign fatty tissue admixed with foci of unremarkable thymic tissue; however, it also harbored a central solid mass showing undifferentiated thymic carcinoma associated with a type B2 thymoma. The carcinoma cells were positive for cytokeratin AE1/AE3, cytokeratin 19, and cytokeratin 8/18. They were negative for vimentin, cytokeratin 7, cytokeratin 20, CD5, epithelial membrane antigen, CD30, placental alkaline phosphatase, carcinoembryonic antigen, CD99, leukocyte common antigen, Epstein-Barr virus, inhibin alpha, and protein gene product 9.5. Rare tumor cells showed positive staining for chromogranin and synaptophysin.
Haddad
Hussam
H
Department of Pathology, King Hussein Cancer Center, Amman, Jordan. msughayer@khcc.jo
Joudeh
Amani
A
El-Taani
Hani
H
Mansour
Asem
A
Morcos
Basem
B
Fayoumi
Said
S
Sughayer
Maher
M
D000328:Adult; D005260:Female; D006801:Humans; D053539:Keratin-19 / Q000378:metabolism; D053533:Keratin-8 / Q000378:metabolism; D008067:Lipoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D013945:Thymoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D013953:Thymus Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology
D053539:Keratin-19; D053533:Keratin-8