title: Cost-effectiveness of intraperitoneal chemohyperthermia in the treatment of peritoneal carcinomatosis from colorectal cancer.
abstract: OBJECTIVE
  Our purpose was to assess the cost-effectiveness of intraperitoneal chemohyperthermia (IPCH) compared to palliative chemotherapy (STANDARD) against peritoneal carcinomatosis arising from colorectal cancer.
  
  
  METHODS
  We performed a retrospective study of 96 patients whose peritoneal carcinomatosis had been diagnosed between January 1998 and December 2003 and treated either with IPCH or with palliative chemotherapy in French comprehensive cancer centers. Patients were followed up over a 3-year period. Effectiveness was measured by restricted mean survival at 3 years. The Bang and Tsiatis method was used to handle cost-censored data. The confidence limits of the mean cost per patient in each group and the mean incremental cost per life-year saved were computed using 1000 bootstrapreplicates. We also computed an acceptability curve for the incremental cost-effectiveness ratio (ICER).
  
  
  RESULTS
  We found that IPCH improved survival and was more costly than STANDARD treatment. Over a 3-year observation period, IPCH yielded an average survival gain of 8.3 months at the additional cost of euro58,086 (95% confidence interval 35,893-112,839) per life-year saved.
  
  
  CONCLUSIONS
  The ICER of IPCH is acceptable given the severity and burden of peritoneal carcinomatosis for which there is no alternative curative treatment.
authors.affiliation: Health Economics Department, Gustave Roussy Institute, Villejuif, France. bonastre@igr.fr
authors.forename: Julia
authors.initials: J
authors.lastname: Bonastre
authors.forename: Julie
authors.initials: J
authors.lastname: Chevalier
authors.forename: Dominique
authors.initials: D
authors.lastname: Elias
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Classe
authors.forename: Gwenaël
authors.initials: G
authors.lastname: Ferron
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Guilloit
authors.forename: Frédéric
authors.initials: F
authors.lastname: Marchal
authors.forename: Pierre
authors.initials: P
authors.lastname: Meeus
authors.forename: Gerard
authors.initials: G
authors.lastname: De Pouvourville
mesh_terms: D000970:Antineoplastic Agents / Q000191:economics*; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000473:pathology*; D003362:Cost-Benefit Analysis; D006801:Humans; D006979:Hyperthermia, Induced / Q000191:economics*; D017059:Models, Econometric; D010166:Palliative Care / Q000191:economics*; D010534:Peritoneal Neoplasms / Q000628:therapy*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents