title: Monoclonal anti-TNFalpha antibody (infliximab) in the treatment of patient with thyroid associated ophthalmopathy.
abstract: TNFalpha (tumor necrosis factor alpha) plays a central role in the development of thyroid associated ophthalmopathy (TAO). We describe and document by ophthalmic (CAS and NO SPECS scales) and radiological (MRI) evaluation a positive effect of anti-TNFalpha antibody (infliximab) administration on active TAO in a 58 years old woman with Graves' disease. The single dose of infliximab administration resulted in a dramatic reduction of inflammation studies and improvement of visual function as measured by MRI and CAS and NO SPECS scales, without noticeable short-term side effects. A randomized prospective study is needed to determine whether infliximab proves to be sufficiently effective in reducing the inflammatory symptoms of TAO, and whether it can be administered safely for a prolonged period without side effects.
authors.affiliation: Department of Clinical Endocrinology, Medical University of Lódź, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Komorowski
authors.forename: Joanna
authors.initials: J
authors.lastname: Jankiewicz-Wika
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Siejka
authors.forename: Hanna
authors.initials: H
authors.lastname: Lawnicka
authors.forename: Anna
authors.initials: A
authors.lastname: Kłysik
authors.forename: Roman
authors.initials: R
authors.lastname: Goś
authors.forename: Agata
authors.initials: A
authors.lastname: Majos
authors.forename: Ludomir
authors.initials: L
authors.lastname: Stefańczyk
authors.forename: Henryk
authors.initials: H
authors.lastname: Stepień
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005260:Female; D049970:Graves Ophthalmopathy / Q000188:drug therapy*; D006801:Humans; D000069285:Infliximab; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D000069285:Infliximab