Apolipoprotein D expression absence in degenerating neurons of human central nervous system.
Apolipoprotein D (apo D), a lipocalin transporter of small hydrophobic molecules could play an important role in several neurodegenerative diseases. However, its role in those diseases remains unclear. There has been reported increments of apo D in relation with different neuropathologic diseases. Recently, we reported the absence of apo D in neurons of substantia nigra which can contribute to the lability of neurons to oxidative damage. In order to determine the relationship between apo D expression and neuronal death, we studied the expression of apo D in various regions of human brains from patients without any neurological or psychological disorders, in relation with the neuronal damage revealed by Fluoro-Jade B staining. The absence of expression for apo D in injured neurons and the negative staining for Fluoro-Jade B of neurons that express apo D was observed in all sections studied. These findings are in accordance with the role possibly played by apo D in the neuroprotection of the nervous system.
Navarro
Ana
A
Department of Morphology and Cellular Biology, University of Oviedo, Asturias, Spain.
Ordóñez
Cristina
C
Martínez
Eva
E
Pérez
Cristina
C
Astudillo
Aurora
A
Tolivia
Jorge
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053399:Apolipoproteins D / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism* / Q000473:pathology; D005452:Fluoresceins; D005456:Fluorescent Dyes; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009410:Nerve Degeneration / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D009930:Organic Chemicals
D053399:Apolipoproteins D; D015415:Biomarkers; D005452:Fluoresceins; D005456:Fluorescent Dyes; D009930:Organic Chemicals; C435731:fluoro jade