title: IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.
abstract: Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a]pyridino-pyridines and benzimidazolo-pyridines was explored.
authors.affiliation: UCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK.
authors.forename: George M
authors.initials: GM
authors.lastname: Buckley
authors.forename: Richard
authors.initials: R
authors.lastname: Fosbeary
authors.forename: Joanne L
authors.initials: JL
authors.lastname: Fraser
authors.forename: Lewis
authors.initials: L
authors.lastname: Gowers
authors.forename: Alicia P
authors.initials: AP
authors.lastname: Higueruelo
authors.forename: Lynwen A
authors.initials: LA
authors.lastname: James
authors.forename: Kerry
authors.initials: K
authors.lastname: Jenkins
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Mack
authors.forename: Trevor
authors.initials: T
authors.lastname: Morgan
authors.forename: David M
authors.initials: DM
authors.lastname: Parry
authors.forename: William R
authors.initials: WR
authors.lastname: Pitt
authors.forename: Oliver
authors.initials: O
authors.lastname: Rausch
authors.forename: Marianna D
authors.initials: MD
authors.lastname: Richard
authors.forename: Verity
authors.initials: V
authors.lastname: Sabin
mesh_terms: D004353:Drug Evaluation, Preclinical; D053592:Interleukin-1 Receptor-Associated Kinases / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D047428:Protein Kinase Inhibitors; D011725:Pyridines; D053592:Interleukin-1 Receptor-Associated Kinases; C001439:imidazo(1,2-a)pyridine