Potential role of the ubiquitin-proteasome system in atherosclerosis: aspects of a protein quality disease.
Misfolded or damaged proteins are recognized intracellularly by protein quality mechanisms. These include chaperones and the ubiquitin-proteasome system, which aim at restoration of protein function and protein removal, respectively. A number of studies have outlined the functional significance of the ubiquitin-proteasome system for the heart and, as of recently, for the vascular system. This review summarizes these recent findings with a focus on atherosclerosis. In particular, this paper reflects on the viewpoint of atherosclerosis as a protein quality disease.
Herrmann
Joerg
J
Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. joerg@mayo.edu
Soares
Sandra M
SM
Lerman
Lilach O
LO
Lerman
Amir
A
D050197:Atherosclerosis / Q000503:physiopathology*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000502:physiology*; D011487:Protein Conformation; D017510:Protein Folding; D025801:Ubiquitin / Q000502:physiology; D043743:Ubiquitin-Protein Ligase Complexes / Q000502:physiology*
D025801:Ubiquitin; D043743:Ubiquitin-Protein Ligase Complexes; D046988:Proteasome Endopeptidase Complex