title: [Anticoagulation with hirudin for repeat cardiac surgery in a patient with heparin induced thrombocytopaenia].
abstract: The authors present the case of a patient with heparin induced thrombocytopaenia who needed anticoagulation during the perioperative period of a third repeat cardiac operation without transfusions. Prostacyclin pretreatment was contraindicated because of critical aortic stenosis, heparinoids could not have been used due to necessity of postoperative anticoagulation. Recombinant hirudin was applied and its effect was monitored with ekarin coagulation time. Hirudin anticoagulation was continued until the proper INR was reached in the postoperative period. There were no intra- and postoperative complications detected, and there was no need for transfusion either. On his long-term follow-up, 6.5 years after the last cardiac surgery the patients was feeling well and had no complaints.
  
  
  CONCLUSIONS
  Open heart operation of a patient with heparin induced thrombocythopenia can be performed safely by total anticoagulation with lepirudin if it is conducted by ecarin clotting time.
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Aneszteziológiai és Intenzív Terápiás Tanszék, Debrecen. hermank@dote.hu
authors.forename: Katalin
authors.initials: K
authors.lastname: Herman
authors.forename: Miklós
authors.initials: M
authors.lastname: Vaszily
authors.forename: Lajos
authors.initials: L
authors.lastname: Szentgyörgyi
authors.forename: Eva
authors.initials: E
authors.lastname: Ajzner
authors.forename: László
authors.initials: L
authors.lastname: Muszbek
authors.forename: Arpád
authors.initials: A
authors.lastname: Péterffy
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects*; D001780:Blood Coagulation Tests / Q000379:methods; D006348:Cardiac Surgical Procedures / Q000379:methods*; D010450:Endopeptidases; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D024764:Hirudin Therapy / Q000379:methods; D006629:Hirudins / Q000008:administration & dosage*; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011994:Recombinant Proteins / Q000008:administration & dosage; D012086:Reoperation; D013921:Thrombocytopenia / Q000139:chemically induced*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006629:Hirudins; D011994:Recombinant Proteins; D006493:Heparin; D010450:Endopeptidases; C020097:ecarin; C083544:lepirudin