Another niche for Notch.
The Notch signaling pathway patterns the developing nephron along the proximal-distal axis during renal development. In an adult acute tubular necrosis model, Kobayashi et al. now show expression of many Notch components and the activation of Notch target genes, suggesting a critical function for Notch in regenerating proximal tubules.
Dressler
G R
GR
Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA. dressler@umich.edu
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007684:Kidney Tubules / Q000254:growth & development* / Q000502:physiology*; D051880:Receptors, Notch / Q000378:metabolism*; D012038:Regeneration; D015398:Signal Transduction; D015533:Transcriptional Activation
D051880:Receptors, Notch