[Hematopoietic stem cell transplantation in autoimmune diseases].
Transplantation of hematopoietic stem cells, which are capable of self renewal and reconstitution of all types of blood cells, can be a treatment for numerous potential lethal diseases, including leukemias and lymphomas. It may now be applicable for the treatment of severe autoimmune diseases, such as therapy-resistant multiple sclerosis, lupus and systemic sclerosis. Studies in animal models show that the transfer of hematopoietic stem cells can reverse autoimmunity. The outcome of ongoing clinical trials, as well as of studies in patients and animal models, will help to determine the role that stem-cell transplantation can play in the treatment of autoimmune diseases.
Albarracín
Flavio
F
Unidad de Trasplante de Médula Osea, División de Reumatología, Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires, Argentina. fhalbarracin@gmail.com
López Meiller
María José
MJ
Naswetter
Gustavo
G
Longoni
Héctor
H
D000818:Animals; D001327:Autoimmune Diseases / Q000473:pathology / Q000601:surgery*; D018450:Disease Progression; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000473:pathology / Q000601:surgery; D008297:Male; D051379:Mice; D009103:Multiple Sclerosis / Q000473:pathology / Q000601:surgery; D012595:Scleroderma, Systemic / Q000473:pathology / Q000601:surgery; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous