Molecular landmarks along the axonal route: axonal transport in health and disease.
Axonal transport of organelles has emerged as a key process in the regulation of neuronal differentiation and survival. Several components of this specialised transport machinery, their regulators and vesicular cargoes are mutated or altered in many neurodegenerative conditions. The molecular characterisation of these mechanisms has furthered our understanding of neuronal homeostasis, providing insights into the spatio-temporal control of membrane traffic and signalling in neurons with a precision not achievable in other cellular systems. Here, we summarise the recent advances in the field of axonal trafficking of different organelles, and the essential role of motor and adaptor proteins in this process.
Salinas
Sara
S
Molecular NeuroPathobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Bilsland
Lynsey G
LG
Schiavo
Giampietro
G
D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism*; D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000502:physiology*; D006801:Humans; D020409:Molecular Motor Proteins / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology; D015388:Organelles / Q000502:physiology*
D033942:Adaptor Proteins, Vesicular Transport; D020409:Molecular Motor Proteins