title: Portal venous stasis during liver resection does not affect platelet aggregability.
abstract: BACKGROUND
  To reduce intraoperative blood loss in liver resections surgical bleeding control is often performed by a complete inflow obstruction of the liver called Pringle manoeuvre leading to a portal venous stasis. Platelet aggregability may be affected by this circulatory stasis.
  
  
  METHODS
  A study population of 11 patients (37-67 years old, 7 females and 4 males) with hepatic tumours underwent elective liver resection. Pringle manoeuvre of up to 50 min duration was used in 4 patients. The other 7 patients were operated using selective vascular clamping. Platelets were aggregated before and after liver resection with adenosine diphosphate, collagen and ristocetin (according to Born).
  
  
  RESULTS
  Mean maximal amplitudes of platelet aggregation were comparable before and after liver resection. Statistic analysis did not detect a significant difference between the values before and after liver resection as well as between Pringle manoeuvre and selective vascular clamping.
  
  
  CONCLUSIONS
  Induced platelet aggregability is not affected by the method of surgical bleeding control used in liver resection. Platelet aggregability seems to be resistant even to portal venous stasis of up to 50 min during Pringle manoeuvre.
authors.affiliation: Department of General, Visceral and Vascular Surgery, Hospital Worms, Worms, Germany. malte.weinrich@gmx.de
authors.forename: Malte
authors.initials: M
authors.lastname: Weinrich
authors.forename: Bernhard
authors.initials: B
authors.lastname: Stephan
authors.forename: Christel
authors.initials: C
authors.lastname: Weiss
authors.forename: Stefanie
authors.initials: S
authors.lastname: Windischmann
authors.forename: Berit
authors.initials: B
authors.lastname: Kopp
authors.forename: Gerhard
authors.initials: G
authors.lastname: Pindur
authors.forename: Martin K
authors.initials: MK
authors.lastname: Schilling
mesh_terms: D000328:Adult; D000368:Aged; D016063:Blood Loss, Surgical; D005260:Female; D006488:Hemostasis, Surgical; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D008099:Liver / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010976:Platelet Count; D011169:Portal Vein / Q000473:pathology*; D013514:Surgical Procedures, Operative; D013997:Time Factors