Identification of new quantitative trait Loci (other than the PRNP gene) modulating the scrapie incubation period in sheep.
Although susceptibility to scrapie is largely controlled by the PRNP gene, we have searched for additional genomic regions that affect scrapie incubation time in sheep, using two half-sib families with a susceptible PRNP genotype and naturally infected by scrapie. Quantitative trait loci were detected on OAR6 and OAR18.
Moreno
C R
CR
INRA, UR 631 Amélioration Génétique des Animaux, BP52627, 31326 Castanet-Tolosan, France. moreno@toulouse.inra.fr
Cosseddu
G M
GM
Schibler
L
L
Roig
A
A
Moazami-Goudarzi
K
K
Andreoletti
O
O
Eychenne
F
F
Lajous
D
D
Schelcher
F
F
Cribiu
E P
EP
Laurent
P
P
Vaiman
D
D
Elsen
J M
JM
D000818:Animals; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D007113:Immunity, Innate / Q000235:genetics*; D016013:Likelihood Functions; D040641:Quantitative Trait Loci / Q000235:genetics*; D012608:Scrapie / Q000235:genetics*; D012756:Sheep; D016019:Survival Analysis; D013997:Time Factors