Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment.
Growing evidence advanced the idea that the soluble form of the receptor for advanced glycation end-products (sRAGE) might serve as a risk marker for several disorders including Alzheimer disease. We found a reduced level of circulating sRAGE in patients with mild cognitive impairment (MCI). The reduction of sRAGE in MCI, as well as the anticipation of the disease in patients with the lowest sRAGE levels (<or=225 pg/ml), suggest a role of the RAGE axis in the pathogenesis of the disease.
Ghidoni
R
R
NeuroBioGen Lab-Memory Clinic, IRCCS Centro S. Giovanni di Dio-FBF, AFaR, via Pilastroni 4, 25125 Brescia, Italy.
Benussi
L
L
Glionna
M
M
Franzoni
M
M
Geroldi
D
D
Emanuele
E
E
Binetti
G
G
D017668:Age of Onset; D000368:Aged; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D013223:Statistics as Topic
D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic