title: Soluble FcgammaRIIIa(Mphi) levels in plasma correlate with carotid maximum intima-media thickness (IMT) in subjects undergoing an annual medical checkup.
abstract: Macrophages play a major role in the development of vascular lesions in atherogenesis. The cells express FcgammaRIIIa (CD16) identical to that in NK cells, but with a cell type-specific glycosylation, and these soluble forms (sFcgammaRIIIa) are present in plasma. We measured sFcgammaRIIIa(Mphi) derived from macrophages in plasma from subjects undergoing an annual medical checkup. The levels of sFcgammaRIIIa(Mphi) increased with age, and correlated positively with body mass index, blood pressure, LDL cholesterol to HDL cholesterol ratio, triglycerides, hemoglobin A1c, and creatinine, but negatively with HDL-cholesterol levels. The sFcgammaRIIIa(Mphi) levels were related to the number of risk factors for atherosclerosis: such as aging, current smoking, diabetes, hypertension, hyper-LDL-cholesterolemia, hypo-HDL-cholesterolemia, and family history of atherosclerotic diseases. In addition, the sFcgammaRIIIa(Mphi) levels were correlated with carotid maximum intima-media thickness (IMT). These findings indicate the macrophages are activated during the incipient stage of atherosclerosis, and suggest sFcgammaRIIIa(Mphi) may be used as a predictive marker for atherosclerosis.
authors.affiliation: Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University, Osaka, Japan. masuda@takii.kmu.ac.jp
authors.forename: Midori
authors.initials: M
authors.lastname: Masuda
authors.forename: Katsuya
authors.initials: K
authors.lastname: Amano
authors.forename: Shi Yan
authors.initials: SY
authors.lastname: Hong
authors.forename: Noriko
authors.initials: N
authors.lastname: Nishimura
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Fukui
authors.forename: Masamichi
authors.initials: M
authors.lastname: Yoshika
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Komiyama
authors.forename: Hiroya
authors.initials: H
authors.lastname: Masaki
authors.forename: Toshiji
authors.initials: T
authors.lastname: Iwasaka
authors.forename: Hakuo
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis; D002339:Carotid Arteries / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010808:Physical Examination; D011379:Prognosis; D017452:Receptors, IgG / Q000097:blood*; D012995:Solubility; D017539:Tunica Intima / Q000033:anatomy & histology*
chemical_list: C496124:FCGR3A protein, human; D017452:Receptors, IgG