Nitric oxide-induced resistance or sensitization to death in tumor cells.
This report summarizes the present state of our knowledge pertaining to the NO-induced resistance or sensitization of tumor cell death. The effects of NO and its synergy with members of the TNF family, with cytotoxic drugs, and with ionizing radiations have been investigated. The dual effect of NO-induced resistance or sensitization and the underlying molecular mechanisms are discussed.
Jeannin
Jean-François
JF
EPHE, Laboratoire d'immunologie et immunothérapie des cancers, Inserm, U866, Dijon, F-21000, France. jean-francois.Jeannin@u-bourgogne.fr
Leon
Lissbeth
L
Cortier
Marion
M
Sassi
Néjia
N
Paul
Catherine
C
Bettaieb
Ali
A
D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy; D009569:Nitric Oxide / Q000502:physiology*; D011878:Radiotherapy; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D000970:Antineoplastic Agents; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide