title: An "anaplastic" Kaposi's sarcoma mimicking a Stewart-Treves syndrome. A case report and a review of literature.
abstract: Cutaneous angiosarcoma (AGS) developing in a lymphedematous arm, after lymphadenectomy in the context of breast cancer, is the definition of the classical Stewart-Treves syndrome. Like AGS, many tumors such as Kaposi's sarcoma (KS) could develop in chronic lymphedema. We describe the case of a 50-year-old woman who presented with several nodules on the left lymphedematous arm evocative of a Stewart-Treves syndrome, 2 years after a left mastectomy and a homolateral lymphadenectomy. The histological examination revealed an atypical vascular proliferation suggesting AGS, but endothelial atypical cells nuclei were strongly stained by herpes human virus 8 antibody. The final diagnosis was an "anaplastic" KS mimicking a Stewart-Treves syndrome. The total regression of the lesion was obtained by elastic contention and intradermic liposomal doxorubicin. "Anaplastic" KS is a rare histological form of nodular KS, which mimics a cutaneous AGS but classically expresses herpes human virus 8. It is essential to know about this entity, particularly in a lymphedematous arm, to avoid aggressive treatment such as amputation.
authors.affiliation: Pôle de biologie-Département d'Anatomie et Cytologie Pathologiques, CHU Grenoble, France. DSalameire@chu-grenoble.fr
authors.forename: Dimitri
authors.initials: D
authors.lastname: Salameire
authors.forename: Isabelle
authors.initials: I
authors.lastname: Templier
authors.forename: Julie
authors.initials: J
authors.lastname: Charles
authors.forename: Nicole
authors.initials: N
authors.lastname: Pinel
authors.forename: Patrice
authors.initials: P
authors.lastname: Morand
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Leccia
authors.forename: Sylvie
authors.initials: S
authors.lastname: Lantuejoul
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006394:Hemangiosarcoma / Q000175:diagnosis*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D008204:Lymphangiosarcoma / Q000175:diagnosis*; D008209:Lymphedema / Q000209:etiology / Q000473:pathology*; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D013577:Syndrome; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D014764:Viral Proteins; C107890:assembly protein, Human herpesvirus 8