title: A case of paroxysmal nocturnal hemoglobinuria presenting with intra-abdominal bleeding due to splenic rupture, developing renal infarct.
abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder characterized by intravascular hemolysis, hemoglobinuria, and thrombosis. Thrombotic attacks are life threatening and are responsible for nearly 50% of PNH-related deaths. Compared with thrombotic events, bleeding related to thrombocytopenia in PNH is quite rare. This report describes an atypical clinical presentation with problems in the diagnosis and management of a woman who presented with a splenic infarct followed by massive intra-abdominal bleeding due to splenic rupture. She also developed a renal infarct during hospitalization after diagnosis.
authors.affiliation: Division of General Internal Medicine, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. drsamiuzun@gmail.com
authors.forename: S
authors.initials: S
authors.lastname: Uzun
authors.forename: N
authors.initials: N
authors.lastname: Alpay
authors.forename: G B
authors.initials: GB
authors.lastname: Ozturk
authors.forename: B
authors.initials: B
authors.lastname: Saka
authors.forename: M
authors.initials: M
authors.lastname: Yenerel
authors.forename: N
authors.initials: N
authors.lastname: Erten
authors.forename: M A
authors.initials: MA
authors.lastname: Karan
authors.forename: C
authors.initials: C
authors.lastname: Taşcioglu
mesh_terms: D015746:Abdominal Pain / Q000097:blood / Q000000981:diagnostic imaging; D000328:Adult; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications / Q000175:diagnosis*; D006470:Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D007238:Infarction / Q000000981:diagnostic imaging / Q000209:etiology*; D007668:Kidney / Q000098:blood supply*; D012422:Rupture, Spontaneous / Q000150:complications / Q000209:etiology; D013159:Splenic Infarction / Q000150:complications / Q000209:etiology; D013161:Splenic Rupture / Q000150:complications / Q000209:etiology*; D014057:Tomography, X-Ray Computed