Serial assessment of immune status by circulating CD8 effector T cell frequencies for posttransplant infectious complications.
To clarify the role of CD8+ effector T cells for infectious complications, 92 recipients were classified according to the hierarchical clustering of preoperative CD8+CD45 isoforms: Group I was naive, Group II was effector memory, and Group III was effector (E) T cell-dominant. The posttransplant infection rates progressively increased from 29% in Group I to 64.3% in Group III recipients. The posttransplant immune status was compared with the pretransplant status, based on the measure (% difference) and its graphical form (scatter plot). In Groups I and II, both approaches showed a strong upward deviation from pretransplant status upon posttransplant infection, indicating an enhanced clearance of pathogens. In Group III, in contrast, both approaches showed a clear downward deviation from preoperative status, indicating deficient cytotoxicity. The % E difference and scatter plot can be used as a useful indicator of a posttransplant infectious complication.
Uemoto
Shinji
S
Department of Transplantation and Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Ozawa
Kazue
K
Egawa
Hiroto
H
Takada
Yasutsugu
Y
Sato
Hiroshi
H
Teramukai
Satoshi
S
Kasahara
Mureo
M
Ogawa
Kohei
K
Ono
Masako
M
Takai
Kenji
K
Fukushima
Masanori
M
Inaba
Kayo
K
Tanaka
Koichi
K
D000328:Adult; D000368:Aged; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D007239:Infections / Q000453:epidemiology / Q000209:etiology / Q000276:immunology / Q000401:mortality; D016031:Liver Transplantation / Q000009:adverse effects* / Q000276:immunology*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology / Q000276:immunology / Q000401:mortality