title: Anti-infective and cytotoxic compounds present in Blepharodon nitidum.
abstract: A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3beta-ol and 25-hydroperoxycycloart-23-en-3beta-ol, exhibited in vitro anti- Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, KY, U.S.A.
authors.forename: José C
authors.initials: JC
authors.lastname: Aponte
authors.forename: Yannick
authors.initials: Y
authors.lastname: Estevez
authors.forename: Robert H
authors.initials: RH
authors.lastname: Gilman
authors.forename: Walter H
authors.initials: WH
authors.lastname: Lewis
authors.forename: Rosario
authors.initials: R
authors.lastname: Rojas
authors.forename: Michel
authors.initials: M
authors.lastname: Sauvain
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Vaisberg
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Hammond
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure
chemical_list: D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic