title: The value of umbilical artery Doppler velocimetry in the antenatal surveillance of uncomplicated monochorionic twin pregnancies.
abstract: OBJECTIVE
  To investigate the predictive value of abnormal umbilical artery Doppler findings on outcome in uncomplicated monochorionic (MC) twin pregnancies.
  
  
  METHODS
  Sixty-seven MC twin pregnancies, with antenatal care and delivery at the University Medical Center, Utrecht, The Netherlands, between 1999 and 2004, were studied. Pregnancies with antenatal signs of twin-to-twin transfusion syndrome were excluded. We analyzed the data according to both the last Doppler measurement of the umbilical artery before delivery and the presence of any abnormal Doppler measurement during the course of pregnancy. Risks of mortality and total neonatal morbidity were stratified according to the Doppler findings in one or both fetuses at the time of each standard ultrasound assessment in order to estimate the risk associated with an abnormal Doppler finding at or before that specific gestational age.
  
  
  RESULTS
  Mortality rates were similar in the normal and abnormal Doppler groups. Using both group definitions, total neonatal morbidity was higher in the abnormal Doppler group; this was significant at > 32 weeks' gestation, and was due to lower birth weight and earlier gestational age at delivery. There was no mortality at > or = 36 weeks in the abnormal Doppler group, but there were four perinatal deaths in the normal Doppler group. Gestational age at delivery was significantly lower when one or more abnormal Doppler findings had been present (median, 34 + 1 weeks vs. 36 + 3 weeks) and infants with abnormal Doppler findings weighed on average 261 g (95% CI, 21-502 g) less than those with normal findings.
  
  
  CONCLUSIONS
  In MC twins, abnormal Doppler flow of the umbilical artery identifies a subgroup at risk for preterm delivery, low birth weight and neonatal morbidity, but with a similar mortality risk to those with normal Doppler flow. At term, mortality occurred only in the group with normal Doppler findings, suggesting that fetal surveillance is insufficient in uncomplicated term MC twin pregnancies.
authors.affiliation: Department of Obstetrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands. k.e.a.hack@umcutrecht.nl
authors.forename: K E A
authors.initials: KE
authors.lastname: Hack
authors.forename: J J
authors.initials: JJ
authors.lastname: Kaandorp
authors.forename: J B
authors.initials: JB
authors.lastname: Derks
authors.forename: S G
authors.initials: SG
authors.lastname: Elias
authors.forename: L
authors.initials: L
authors.lastname: Pistorius
authors.forename: G H A
authors.initials: GH
authors.lastname: Visser
mesh_terms: D001783:Blood Flow Velocity; D002823:Chorion / Q000002:abnormalities*; D005260:Female; D005330:Fetofetal Transfusion / Q000000981:diagnostic imaging; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D017078:Laser-Doppler Flowmetry; D054238:Perinatal Mortality; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D011673:Pulsatile Flow; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D018709:Statistics, Nonparametric; D014430:Twins, Monozygotic; D014463:Ultrasonography; D014469:Umbilical Arteries / Q000000981:diagnostic imaging*