title: [Afobazole metabolism in rats].
abstract: Metabolism of afobazole in rats has been studied using mass-spectrometry and HPLC, which revealed 17 products of afobazole biotransformation along with the parent compound. The structures of six afobazole metabolites were established and confirmed by comparison of HPLC retention times with the synthetic reference compounds and HPLC/mass spectrometry. Other metabolites were characterized by the masses of molecular ions. A significant fraction of the drug dose is biotransformed with the formation of hydroxylated benzimidazole moiety and oxidated morpholine.
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
authors.forename: A O
authors.initials: AO
authors.lastname: Viglinskaia
authors.forename: T Ia
authors.initials: TIa
authors.lastname: Mozhaeva
authors.forename: G B
authors.initials: GB
authors.lastname: Kolyvanov
authors.forename: A A
authors.initials: AA
authors.lastname: Litvin
authors.forename: N I
authors.initials: NI
authors.lastname: Avdiunina
authors.forename: V L
authors.initials: VL
authors.lastname: Savel'ev
authors.forename: V P
authors.initials: VP
authors.lastname: Zgerdev
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001562:Benzimidazoles / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D008297:Male; D013058:Mass Spectrometry; D009025:Morpholines / Q000097:blood / Q000378:metabolism* / Q000652:urine; D051381:Rats
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines