[Expression of FHIT gene protein in laryngeal carcinoma].
OBJECTIVE
To investigate the role and clinical significance of the expression of FHIT gene in development and progression of laryngeal squamous cell carcinoma(LSCC).


METHODS
The expression FHIT protein was detected by immunohistochemistry method in the 52 cases with LSCC and 23 cases of adjacent cancer tissues and 10 cases of laryngeal normal mucosa. The expression of FHIT was analyzed in LSCC with different clinicopathological parameters.


RESULTS
The expression of FHIT in normal tissues (90.0%) and adjacent tissues (78.3%) was obvious higher than that in LSCC (46.2%), which had statistical significant difference (P < 0.01). There was a positive correlation between FHIT expression and TNM staging, lymph node metastasis; but not pathological grade.


CONCLUSIONS
The loss of FHIT expression may be correlated with the development and progression of laryngeal carcinoma. FHIT may be an important tumor suppressor gene in LSCC.
Cao
Litang
L
Department of Otolaryngology, Puren Hospital, Beijing, 100062, China. clt1974@sohu.com
Chen
Xiaoming
X
Wang
Binquan
B
D017766:Acid Anhydride Hydrolases / Q000378:metabolism*; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase