title: The overexpression of c-met as a prognostic indicator for gastric carcinoma compared to p53 and p21 nuclear accumulation.
abstract: The purpose of this study was to clarify the relationship of the immunohistochemical expression of c-met, p53 and p21 with clinicopathological parameters and prognosis in gastric carcinomas. We analyzed specimens from 114 gastric cancer patients (median age 64 years, range: 33-86) who underwent gastrectomy with lymphadenectomy. Specimens were categorized according to the tumor differentiation, based on UICC, WHO, Laurén, Ming and Goseki classifications. Specimens were examined immunohistochemically with antibodies against c-met, p53 and p21. The expression was evaluated semiquantitatively and correlated with the clinicopathological parameters. The c-met staining pattern was positive in 73.7%. P53 and p21 were positive in 86.8 and 67.5%, respectively. No significant correlation between c-met or p21 expression and the clinicopathological parameters was seen. A significant increase of p53 expression was observed in stage pT3 and -4. The overexpression of c-met and p53 was significantly associated with a poor prognosis in the univariate survival analysis. In the multivariate analysis this impact was maintained for c-met. P21 proved to be a significant prognostic factor in the multivariate analysis. Our data suggest that the overexpression of c-met and p21 may represent independent prognostic factors in gastric carcinoma.
authors.affiliation: Institute of Pathology, University of Cologne, Cologne, Germany. u.drebber@uni-koeln.de
authors.forename: Uta
authors.initials: U
authors.lastname: Drebber
authors.forename: Stephan E
authors.initials: SE
authors.lastname: Baldus
authors.forename: Britt
authors.initials: B
authors.lastname: Nolden
authors.forename: Guido
authors.initials: G
authors.lastname: Grass
authors.forename: Elfriede
authors.initials: E
authors.lastname: Bollschweiler
authors.forename: Hans P
authors.initials: HP
authors.lastname: Dienes
authors.forename: Arnulf H
authors.initials: AH
authors.lastname: Hölscher
authors.forename: Stefan P
authors.initials: SP
authors.lastname: Mönig
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000556:secondary / Q000601:surgery; D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000556:secondary / Q000601:surgery; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000556:secondary / Q000601:surgery; D018279:Carcinoma, Signet Ring Cell / Q000378:metabolism / Q000556:secondary / Q000601:surgery; D002467:Cell Nucleus / Q000378:metabolism*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism*; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016159:Tumor Suppressor Protein p53; D019859:Proto-Oncogene Proteins c-met