Preoperative administration of esomeprazole has no influence on frequency of refluxes.
OBJECTIVE
To examine the effect of esomeprazole in a fixed time setting on gastric content volume, gastric acidity, gastric barrier pressure, and reflux propensity.


METHODS
Randomized, controlled, double-blind trial.


METHODS
21 healthy, ASA I physical status volunteers.


METHODS
Esomeprazole was given 12 hours and one hour before investigation. Before the study, a multichannel intraluminal impedance catheter, pH monitoring data logger (PHmetry) catheter, and an intragastric-esophageal manometry catheter were placed nasally after topical anesthesia.


METHODS
Gastric acidity and gastric content volume were determined by PHmetry after aspiration of gastric contents over a nasogastric tube. Gastroesophageal reflux and intragastric-esophageal barrier pressure were investigated by multichannel intraluminal impedance measurement, PHmetry, and intragastric-esophageal manometry.


RESULTS
The pH of gastric contents was significantly (P < 0.001) higher after esomeprazole (mean [25th-75th percentile], 4.2 [3.9-4.8] vs 2.0 [1.9-2.7]), and gastric content volume was significantly (P < 0.001) lower (5.0 mL [3.0-12.0] vs 15 mL [10.0-25.0]) in comparison to placebo. No significant difference between esomeprazole and placebo was found with respect to number of refluxes per person, duration of reflux, or barrier pressure.


CONCLUSIONS
Esomeprazole in a fixed time setting can markedly increase the pH of gastric contents and decrease gastric content volume, but has no influence on the frequency, duration of refluxes, or gastroesophageal barrier pressure.
Jeske
Hans-Christian
HC
Department of Traumatology and Sports Medicine, Innsbruck Medical University, A-6020 Innsbruck, Austria. hans.jeske@i-med.ac.at <hans.jeske@i-med.ac.at>
Borovicka
Jan
J
von Goedecke
Achim
A
Tiefenthaler
Werner
W
Hohlrieder
Matthias
M
Heidegger
Thomas
T
Benzer
Arnulf
A
D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D017097:Electric Impedance; D064098:Esomeprazole / Q000627:therapeutic use*; D005260:Female; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000517:prevention & control*; D005766:Gastrointestinal Contents; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D011312:Pressure
D000897:Anti-Ulcer Agents; D064098:Esomeprazole