[The role of angiotensin-converting enzyme and apolipoprotein E in the development of intracranial aneurysms.].
The distribution of allele and genotype frequencies of the Alu-insertion polymorphism of the angiotensin-converting enzyme (ACE) gene and missence mutations leading to the substitution of arginine to cysteine in positions 112 and 158 of apolipoprotein E (APOE) has been studied in 166 patients with brain intracranial aneurysms and in 192 controls of Russian origin from Ural region. Brain vascular aneurysms with hypertension were associated with the D*D* ACE genotype in men and with the e2 allele and the e2/e3 APOE genotype in women. The association was also observed between the e2 allele and the e2/e3 APOE genotype and family history of stroke, hemorrhages and aneurysms in patients. Men with the I*D* ACE genotype and the e4 APOE allele were at lower risk.
Lebedeva
E R
ER
GOU VPO Ural'skaia gosudarstvennaia meditsinskaia akademiia, MO Novaia bol'nitsa, Ekaterinburg; Institut biokhimii i genetiki Ufimskogo nauchnogo tsentra Rossiĭskoĭ akademii nauk.
Sakovich
V P
VP
Khusainova
R I
RI
Kutuev
I A
IA
Valiev
R R
RR
Khusnutdinova
N N
NN
Khusnutdinova
E K
EK
D001057:Apolipoproteins E / Q000235:genetics; D005838:Genotype; D006801:Humans; D002532:Intracranial Aneurysm; D011110:Polymorphism, Genetic; D012307:Risk Factors
D001057:Apolipoproteins E