title: The Hypolipidemic and Anti-Inflammatory Activity of Boronated Aromatic Amino Acids in CF(1) Male Mice.
abstract: The boronated aromatic amino acids were shown to be potent hypolipidemic agents in mice lowering both serum cholesterol and triglycerides after 16 days. Selective compounds were as effective as the clinical standards. Furthermore, the compounds were effective anti-inflammatory agents reducing local and central pain as well as suppressing LPS induced endotoxic shock in mice. These agents inhibited lysosomal and proteolytic enzymes of the liver and macrophages as a part of their mechanism of action.
authors.affiliation: Division of Medicinal Chemistry and Natural Products University of North Carolina Chapel Hill North Carolina 27559-7360 USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Miller
authors.forename: A
authors.initials: A
authors.lastname: Sood
authors.forename: B F
authors.initials: BF
authors.lastname: Spielvogel
authors.forename: I H
authors.initials: IH
authors.lastname: Hall