title: Molecular electron microscopy: state of the art and current challenges.
abstract: The objective of molecular electron microscopy (EM) is to use electron microscopes to visualize the structure of biological molecules. This Review provides a brief overview of the methods used in molecular EM, their respective strengths and successes, and current developments that promise an even more exciting future for molecular EM in the structural investigation of proteins and macromolecular complexes, studied in isolation or in the context of cells and tissues.
authors.affiliation: Molecular and Cellular Biology, College of Biological Sciences, University of California at Davis, Briggs Hall, 1 Shields Avenue, Davis, California 95616, USA.
authors.forename: Henning
authors.initials: H
authors.lastname: Stahlberg
authors.forename: Thomas
authors.initials: T
authors.lastname: Walz
mesh_terms: D003461:Crystallography; D008854:Microscopy, Electron / Q000379:methods*; D011506:Proteins / Q000737:chemistry / Q000648:ultrastructure; D012680:Sensitivity and Specificity
chemical_list: D011506:Proteins