title: Attenuation corrected gated SPECT for the assessment of left ventricular ejection fraction and volumes.
abstract: OBJECTIVE
  The aim of this study was to evaluate the value of attenuation correction (AC) of Tc-99m tetrofosmin single-photon emission tomography (SPECT) imaging for the assessment of left ventricular ejection fraction (LVEF).
  
  
  METHODS
  Attenuation corrected and non-attenuation corrected (NC) resting Tc-99m tetrofosmin SPECT were compared for the assessment of LVEF. Planar multigated radionuclide angiography (MUGA) served as the reference for LVEF assessment. Patients (n = 56) with left ventricular dysfunction who underwent MUGA and rest gated Tc-99m tetrofosmin SPECT within 1 month were included.
  
  
  RESULTS
  The average LVEF on NC gated SPECT was 37.4 +/- 11.8% and on AC SPECT 38.5 +/- 13.4% (P = NS). The absolute mean difference of the LVEF between the MUGA and NC gated SPECT and AC gated SPECT was -0.2% (95% CI -1.7 to 1.3) and -1.3% (95% CI -2.7 to 0.03), respectively (P = NS both vs. MUGA). The correlation between NC gated SPECT and AC gated SPECT versus MUGA measurement was high with a correlation coefficient of 0.89 (P < 0.01) and 0.92 (P < 0.01), respectively. End-diastolic volumes (EDVs) and end-systolic volumes (ESVs) were significantly higher with AC gated SPECT when compared with NC gated SPECT (both P < 0.001).
  
  
  CONCLUSIONS
  Profile AC gated Tc-99m tetrofosmin SPECT agrees well with MUGA and NC gated Tc-99m tetrofosmin SPECT for the assessment of LVEF. EDVs and ESVs are significantly higher with AC gated SPECT when compared with NC gated SPECT.
authors.affiliation: Department of Nuclear Medicine and Molecular Imaging, Groningen University Medical Center, University of Groningen, Hanzeplein 1, Groningen, the Netherlands. r.h.j.a.slart@ngmb.umcg.nl
authors.forename: Riemer H J A
authors.initials: RH
authors.lastname: Slart
authors.forename: René A
authors.initials: RA
authors.lastname: Tio
authors.forename: Clark J
authors.initials: CJ
authors.lastname: Zeebregts
authors.forename: Antoon T M
authors.initials: AT
authors.lastname: Willemsen
authors.forename: Rudi A J O
authors.initials: RA
authors.lastname: Dierckx
authors.forename: Johan
authors.initials: J
authors.lastname: De Sutter
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004735:Energy Transfer / Q000502:physiology; D005069:Evaluation Studies as Topic; D005260:Female; D015637:Gated Blood-Pool Imaging; D006321:Heart / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000493:pharmacokinetics; D015609:Organotechnetium Compounds / Q000737:chemistry / Q000493:pharmacokinetics; D017785:Photons; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000493:pharmacokinetics; D012107:Research Design; D013318:Stroke Volume; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology*
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C078700:technetium tc-99m tetrofosmin