Comparative Analysis of [Au(en)(2)] and [Pt(en)(2)] non Covalent Binding to Calf Thymus DNA.
Reactions of the complexes bisethylendiammine gold(III) and bisethylendiammine platinum(II) with calfthymus DNA were comparatively analysed. Both complexes bind DNA non-covalently most probably on the basis of electrostatic interactions. Binding of either complex at low ratios results into modest modifications of B-type DNA conformations, as detected by CD. Far larger CD alterations are observed at high ratios. The gold(III) chromophore is scarcely perturbed by DNA addition Binding of [Au(en)(2)]Cl(3) to calf thymus DNA is reversed by sodium cyanide. By analogy with the case of [Pt(en)(2)]Cl(2) it is suggested that Auen acts as a minor groove binder.
Marcon
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CIRCMSB Unit of Florence via Gino Capponi 7 Florence I-50121 Italy.
O'Connell
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Orioli
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Messori
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