title: Synthesis and radioprotective activity of new organosilicon and germanium compounds.
abstract: Silathiazolidine and metalladithioacetals (M = Si, Ge) have been prepared by the interaction of dialkyldichloro- or bis(diethylamino)dialkylsilanes and -germanes with 3-[N-(2- thioethyl)]amino-propanamide (WR-2529) and [1-thioethyl-2-(1-naphtylmethyl)]-2- imidazoline. The study of these compounds in the field of chemical radioprotection has shown a notable decrease in the toxicity and a rather large increase in the radioprotective activity of these new derivatives in comparison with the starting organic compounds.
authors.affiliation: Laboratoire d′Hétérochimie Fondamentale et Appliquée UPRES-A 5069 du CNRS Université Paul Sabatier, 118 route de Narbonne Toulouse Cedex 31062 France.
authors.forename: G
authors.initials: G
authors.lastname: Rima
authors.forename: J
authors.initials: J
authors.lastname: Satgé
authors.forename: R
authors.initials: R
authors.lastname: Dagiral
authors.forename: C
authors.initials: C
authors.lastname: Lion
authors.forename: M
authors.initials: M
authors.lastname: Fatome
authors.forename: V
authors.initials: V
authors.lastname: Roman
authors.forename: J D
authors.initials: JD
authors.lastname: Laval