[Primary pulmonary involvement of NK/T-cell lymphoma: report of two cases with literature review].
OBJECTIVE
To describe the imaging, clinical and pathological features of primary pulmonary involvement of NK/T-cell lymphoma.


METHODS
The imaging, clinical and pathological features of 2 patients with primary pulmonary involvement of NK/T-cell lymphoma were retrospectively analyzed.


RESULTS
The 2 cases (both young women) of NK/T-cell lymphoma were confirmed with CT-guided percutaneous needle lung biopsy and the lung was the primary involved site. They presented similar clinical features, including fever, dry cough, and progressive tachypnea with hypoxia. Bilateral pulmonary parenchymal nodular consolidations with bilateral pleural fluid were detected at admission chest CT scanning. Air bronchogram and halo signs were found in both the cases. The plasma Epstein-Barr virus (EBV) DNA level was 3.65 x 10(5) copies/ml and 1000 copies/ml respectively. The disease deteriorated progressively and the patients survived only 40d and 66d respectively.


CONCLUSIONS
The lungs may be the primary involved sites of NK/T-cell lymphoma and the prognosis is grim.
Xiao
Yong-Long
YL
Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China. xiaoyonglong@hotmail.com
Zhang
De-Ping
DP
Wang
Yihua
Y
D000328:Adult; D017252:CD3 Complex / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D017493:Leukocyte Common Antigens / Q000032:analysis; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D054391:Lymphoma, Extranodal NK-T-Cell / Q000378:metabolism / Q000473:pathology* / Q000821:virology
D017252:CD3 Complex; D019002:CD56 Antigen; D004279:DNA, Viral; D017493:Leukocyte Common Antigens