title: Gait dysfunction in mild cognitive impairment syndromes.
abstract: OBJECTIVE
  To conduct a systematic clinical and quantitative assessment of gait in older adults with mild cognitive impairment (MCI) syndromes.
  
  
  METHODS
  Cross-sectional.
  
  
  METHODS
  Einstein Aging Study, a community-based longitudinal aging study.
  
  
  METHODS
  Fifty-four individuals with amnestic MCI (a-MCI), 62 with nonamnestic-MCI (na-MCI), and 295 healthy controls identified from the Einstein Aging Study participants.
  
  
  METHODS
  Comparison of clinical and quantitative gait performance in subjects with MCI subtypes with that of cognitively normal older adults.
  
  
  RESULTS
  Neurological gaits were more common in a-MCI (31.5%, P=.008) but not in na-MCI (19.4%, P=.55), than in controls (16.3%). Quantitative gait in multiple parameters was worse in both MCI subtypes than in controls. Factor analysis revealed three independent factors representing pace, rhythm, and variability. Subjects with a-MCI had worse rhythm and variability scores than those with na-MCI and controls. Subjects with na-MCI had worse performance on the pace domain than the other two groups. Subjects with MCI and gait abnormalities had higher disability scores than subjects with MCI without gait abnormalities.
  
  
  CONCLUSIONS
  Gait dysfunction is common in older individuals with amnestic and nonamnestic subtypes of MCI.
authors.affiliation: Department of Neurology, Einstein Aging Study, Albert Einstein College of Medicine, Bronx, New York 10461, USA. jverghes@aecom.yu.edu
authors.forename: Joe
authors.initials: J
authors.lastname: Verghese
authors.forename: Matthew
authors.initials: M
authors.lastname: Robbins
authors.forename: Roee
authors.initials: R
authors.lastname: Holtzer
authors.forename: Molly
authors.initials: M
authors.lastname: Zimmerman
authors.forename: Cuiling
authors.initials: C
authors.lastname: Wang
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Xue
authors.forename: Richard B
authors.initials: RB
authors.lastname: Lipton
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000145:classification / Q000150:complications* / Q000175:diagnosis; D003430:Cross-Sectional Studies; D005260:Female; D020233:Gait Disorders, Neurologic / Q000145:classification / Q000209:etiology*; D015577:Geriatric Assessment / Q000379:methods*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests