title: Adaptive diffusion smoothing: a diffusion-based method to reduce IMRT field complexity.
abstract: Inverse-planned intensity modulated radiation therapy (IMRT) is often able to achieve complex treatment planning goals that are unattainable with forward three-dimensional (3D) conformal planning. However, the common use of IMRT has introduced several new challenges. The potentially high degree of modulation in IMRT beams risks the loss of some advantages of 3D planning, such as excellent target coverage and high delivery efficiency. Previous attempts to reduce beam complexity by smoothing often result in plan degradation because the smoothing algorithm cannot distinguish between areas of desirable and undesirable modulation. The purpose of this work is to introduce and evaluate adaptive diffusion smoothing (ADS), a novel procedure designed to preferentially reduce IMRT beam complexity. In this method, a discrete diffusion equation is used to smooth IMRT beams using diffusion coefficients, automatically defined for each beamlet, that dictate the degree of smoothing allowed for each beamlet. This yields a method that can distinguish between areas of desirable and undesirable modulation. The ADS method has been incorporated into our optimization system as a weighted cost function penalty, with two diffusion coefficient definitions designed to promote: (1) uniform smoothing everywhere or (2) smoothing based on cost function gradients with respect to the plan beamlet intensities. The ADS method (with both coefficient types) has been tested in a phantom and in two clinical examples (prostate and head/neck). Both types of diffusion coefficients produce plans with reduced modulation and minimal dosimetric impact, but the cost function gradient-based coefficients show more potential for reducing beam modulation without affecting dosimetric plan quality. In summary, adaptive diffusion smoothing is a promising tool for ensuring that only the necessary amount of beam modulation is used, promoting more efficient and accurate IMRT planning, QA, and delivery.
authors.affiliation: Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA. martha.matuszak@beaumont.edu
authors.forename: Martha M
authors.initials: MM
authors.lastname: Matuszak
authors.forename: Edward W
authors.initials: EW
authors.lastname: Larsen
authors.forename: Kyung-Wook
authors.initials: KW
authors.lastname: Jee
authors.forename: Daniel L
authors.initials: DL
authors.lastname: McShan
authors.forename: Benedick A
authors.initials: BA
authors.lastname: Fraass
mesh_terms: D000465:Algorithms; D004058:Diffusion; D009716:Numerical Analysis, Computer-Assisted; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*