Red cell survival in relation to changes in the hematocrit: more important than you think.
The management of anemia in patients with chronic renal failure has greatly improved with the availability of recombinant human erythropoietin in the late 1980s, leading to a considerable reduction in mortality and morbidity and to an improvement in quality of life. The findings from recent controlled clinical outcome trials have resulted in a rather narrow, generally accepted therapeutic hematocrit target range. However, currently available dosing algorithms do not permit achievement and maintenance of target values within the therapeutic range in many patients. One possible explanation for this failure may be the ignorance of a finite erythrocyte lifespan not integrated into most algorithms. The purpose of this article is to underline the essential role played by the erythrocyte lifespan in the erythropoietic response to recombinant human erythropoietin and to encourage the integration of this concept in the future development of computer-assisted decision support systems.
Kalicki
Robert M
RM
Department of Nephrology and Hypertension, Inselspital, University of Bern, Bern, Switzerland.
Uehlinger
Dominik E
DE
D000465:Algorithms; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D002470:Cell Survival; D003658:Decision Making, Computer-Assisted; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000473:pathology* / Q000502:physiology; D004921:Erythropoietin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006400:Hematocrit; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D004921:Erythropoietin