title: The polymorphism of XRCC3 codon 241 and AFB1-related hepatocellular carcinoma in Guangxi population, China.
abstract: OBJECTIVE
  The relationship between aflatoxin B1 (AFB1) exposure and hepatocellular carcinoma (HCC) has been previously demonstrated and supported with strong epidemiological evidence. However, the role of genetic polymorphism of X-ray cross-complementing group 3 (XRCC3) codon 241 (namely: Thr241Met), which may be involved in the repair of DNA double-strand breaks caused by carcinogens such as AFB1, been less well elaborated.
  
  
  METHODS
  We conducted a case-control study including 491 cases and 862 controls to evaluate the associations between this polymorphism and HCC risk for Guangxi population by means of polymerase chain reaction-restriction fragment length polymorphism analysis.
  
  
  RESULTS
  We found that individuals with the XRCC3 genotypes with codon 241 Met (namely XRCC3-TM or XRCC3-MM) had an increased risk of HCC than those with the homozygote of XRCC3 codon 241 Thr alleles (namely XRCC3-TT, adjusted odds ratios 2.22 and 7.19; 95% confidence intervals 1.72-2.88 and 4.52-11.42, respectively). The risk of HCC, moreover, did appear to differ more significantly among individuals featuring high-level AFB1-DNA adducts, whose adjusted odds ratios (95% confidence intervals) were 11.59 (5.73-23.47) and 37.54 (16.32-86.32), respectively.
  
  
  CONCLUSIONS
  These findings support the hypothesis that the XRCC3 Thr241Met polymorphism may be associated with the risk of AFB1-related HCC among the Guangxi population.
authors.affiliation: Department of Pathology, Youjiang Medical College for Nationalities, Baise, Guangxi Zhuang Autonomous Region, China. xiaolonglong200166@yahoo.com.cn
authors.forename: Xi Dai
authors.initials: XD
authors.lastname: Long
authors.forename: Yun
authors.initials: Y
authors.lastname: Ma
authors.forename: De Ying
authors.initials: DY
authors.lastname: Qu
authors.forename: Yun Guang
authors.initials: YG
authors.lastname: Liu
authors.forename: Zhao Quan
authors.initials: ZQ
authors.lastname: Huang
authors.forename: Yong Zhi
authors.initials: YZ
authors.lastname: Huang
authors.forename: Zhong Hui
authors.initials: ZH
authors.lastname: Lin
authors.forename: Ni Bo
authors.initials: NB
authors.lastname: Wei
authors.forename: Shu Chun
authors.initials: SC
authors.lastname: Zhou
mesh_terms: D000328:Adult; D016604:Aflatoxin B1 / Q000506:poisoning*; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003062:Codon; D004249:DNA Damage; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D003062:Codon; D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3; D016604:Aflatoxin B1