(1-nosyl-5-nitroindol-3-yl)methyl ester: a novel protective group for carboxylic acids.
The usefulness of (1-nosyl-5-nitroindol-3-yl)methyl esters as a novel protective group for carboxylic acid is fully demonstrated. The novel protective group is stable under a broad range of conditions and can easily be deprotected under the mild conditions used for removal of the nosyl (Ns) group. It is orthogonal to the existing protective groups for carboxylic acids such as t-butyl and allyl esters.
Nishimura
Takuya
T
Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
Yamada
Kouhei
K
Takebe
Tohru
T
Yokoshima
Satoshi
S
Fukuyama
Tohru
T
D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*
D002264:Carboxylic Acids; D004952:Esters; D007211:Indoles; D009574:Nitro Compounds