Marine natural product libraries for high-throughput screening and rapid drug discovery.
There is a need for diverse molecular libraries for phenotype-selective and high-throughput screening. To make marine natural products (MNPs) more amenable to newer screening paradigms and shorten discovery time lines, we have created an MNP library characterized online using MS. To test the potential of the library, we screened a subset of the library in a phenotype-selective screen to identify compounds that inhibited the growth of BRCA2-deficient cells.
Bugni
Tim S
TS
Department of Medicinal Chemistry, University of Utah, 30 S. 2000 E. RM 307, Salt Lake City, Utah 84112, USA.
Richards
Burt
B
Bhoite
Leen
L
Cimbora
Daniel
D
Harper
Mary Kay
MK
Ireland
Chris M
CM
D000818:Animals; D024682:BRCA2 Protein / Q000172:deficiency*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D005367:Fiji; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology*
D024682:BRCA2 Protein; D001688:Biological Products; D054852:Small Molecule Libraries; D004247:DNA