title: Efficacy and safety of endoscopic submucosal dissection for gastric cancer in patients with liver cirrhosis.
abstract: Endoscopic submucosal dissection (ESD) has become a widely accepted method for treating gastrointestinal cancer. The aim of this study was to evaluate the efficacy and safety of ESD for gastric cancer in patients with liver cirrhosis. A total of 18 gastric cancers were treated by ESD in 15 patients with cirrhosis. The rate of en bloc resection was 88.9% (16/18). En bloc resection with tumor-free lateral/basal margins (R0 resection) was 77.8% (14/18). Three patients had postoperative bleeding and underwent emergency gastroscopy for hemostasis. No recurrence was observed during the median follow-up of 21.4 months, excluding three patients in whom additional endoscopic resection or surgery was carried out. ESD can be safely performed for gastric cancer in patients with cirrhosis, resulting in a high en bloc resection rate.
authors.affiliation: Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Tokyo, Japan. keiji-tky@umin.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Ogura
authors.forename: M
authors.initials: M
authors.lastname: Okamoto
authors.forename: T
authors.initials: T
authors.lastname: Sugimoto
authors.forename: N
authors.initials: N
authors.lastname: Yahagi
authors.forename: M
authors.initials: M
authors.lastname: Fujishiro
authors.forename: N
authors.initials: N
authors.lastname: Kakushima
authors.forename: S
authors.initials: S
authors.lastname: Kodashima
authors.forename: T
authors.initials: T
authors.lastname: Kawabe
authors.forename: M
authors.initials: M
authors.lastname: Omata
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004210:Dissection; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005753:Gastric Mucosa / Q000601:surgery*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome