Direct synthesis of 1,3-diketones by Rh-catalyzed reductive alpha-acylation of enones.
1,3-Diketones were synthesized from alpha,beta-unsaturated ketones by treatment with acid chlorides and Et(2)Zn in the presence of RhCl(PPh(3))3. This is a very simple and extremely chemoselective reaction to give the adduct at the alpha-position of alpha,beta-unsaturated ketones.
Sato
Kazuyuki
K
Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan.
Yamazoe
Satoshi
S
Yamamoto
Rie
R
Ohata
Shizuka
S
Tarui
Atsushi
A
Omote
Masaaki
M
Kumadaki
Itsumaro
I
Ando
Akira
A
D000215:Acylation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D007659:Ketones; D012238:Rhodium