title: Accumulation of gallium-67 within mature and immature teratoma in pediatric patients: investigation for the uptake mechanism.
abstract: OBJECTIVE
  We encountered cases of mature and immature teratoma with positive uptake of (67)Ga. The objective of this study is to investigate the mechanism of (67)Ga accumulation within mature and immature teratomas by comparing the findings of gallium scan, computed tomography (CT), and autoradiography of surgical specimens with the pathological findings.
  
  
  METHODS
  The subjects comprised 14 children who underwent surgical resection for intra-abdominal mature and immature teratomas, which were histologically proved to be of the mature and immature subtype. Their age ranged from 24 days to 14 years. The origins of the mature teratomas consisted of seven ovaries including one bilateral case, two retroperitoneal, and two sacrococcygeal regions. The origins of the immature teratomas were retroperitoneum in two cases, an ovary and a sacrococcygeal region. Complete surgical excision was feasible in all children. They underwent both gallium scan and CT prior to surgery. Single-photon emission computed tomography was added in some cases. For two gallium-positive cases, radiography and scintigraphy (autoradiography) of the resected specimen were performed.
  
  
  RESULTS
  Of the 14 children, 5 (one with immature and four with mature subtype) showed positive (67)Ga uptake within tumors, which originated from the retroperitoneum in the 3 boys, and from the ovary in the 2 girls. All had typical CT findings of teratoma, including calcifications, fat components, cystic areas, and solid parts. (67)Ga accumulation in the four mature teratomas appeared discretely strong, and was considered to correspond with intralesional calcifications. However, in the remaining one immature teratoma, the gallium distribution was diffuse within the tumor. The comparison between radiography and autoradiography of the resected mature teratomas confirmed the correlation between the intralesional calcifications and areas of (67)Ga accumulation.
  
  
  CONCLUSIONS
  A high-uptake ratio of (67)Ga in benign teratoma was indicated. A close correlation between gallium scan and CT helps to ascertain whether (67)Ga uptake results from malignant and/or immature elements, or mature tissue components.
authors.affiliation: Department of Radiology, Tokyo Metropolitan Kiyose Children's Hospital, Kiyose, Tokyo, Japan. kunieda-mi@umin.ac.jp
authors.forename: Etsuo
authors.initials: E
authors.lastname: Kunieda
authors.forename: Hiroko
authors.initials: H
authors.lastname: Hara
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Morikawa
authors.forename: Seiichi
authors.initials: S
authors.lastname: Hirobe
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Kamagata
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kubo
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging; D000293:Adolescent; D001345:Autoradiography; D002114:Calcinosis / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012186:Retroperitoneal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012445:Sacrococcygeal Region / Q000000981:diagnostic imaging / Q000473:pathology; D013724:Teratoma / Q000000981:diagnostic imaging* / Q000473:pathology; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
chemical_list: D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals