title: Elucidating semantic disorganisation from a word comprehension task: do patients with schizophrenia and bipolar disorder show differential processing of nouns, verbs and adjectives?
abstract: Memory deficits have been reported in schizophrenia and bipolar disorder. However, the precise impact of semantic memory deficits on word comprehension, particularly across grammatical categories, has not been adequately investigated in these disorders. Furthermore, previous studies examining semantic memory have predominantly been designed so that most healthy controls perform at ceiling, questioning the validity of observed differences between patient and control groups. A new word definition task examined word comprehension across grammatical categories, i.e. nouns, verbs and adjectives, and was designed to overcome the ceiling effect. It was administered to 32 schizophrenia patients, 28 bipolar disorder patients and 32 matched healthy controls. Schizophrenia patients had a global impairment on the task but bipolar patients were only impaired on a recognition memory component. Word comprehension, however, across grammatical categories was comparable across groups.
authors.affiliation: Macquarie Centre for Cognitive Science (MACCS), Macquarie University, Sydney, NSW 2109, Australia. srossell@srossell.com
authors.forename: Susan L
authors.initials: SL
authors.lastname: Rossell
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Batty
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000523:psychology; D032882:Comprehension; D035061:Control Groups; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000175:diagnosis* / Q000523:psychology; D007807:Language Tests / Q000706:statistics & numerical data; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000523:psychology; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011932:Reading; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D012660:Semantics; D014825:Vocabulary