[Changes and clinical significance of serum Apelin in patients with severe sepsis and septic shock].
OBJECTIVE
To explore the changes and clinical significance of serum Apelin in patients with severe sepsis and septic shock.


METHODS
We measured the serum level of Apelin with ELISA on different observation days (the 1st, 3rd, and 10th day obtaining the diagnosis) in 26 patients with severe sepsis and septic shock.


RESULTS
Serum Apelin significantly increased in sepsis patients when compared with the normal control group (P<0.01); The serum Apelin levels significantly changed among different observation days (P< 0.01). Serum Apelin level was significantly higher in patients with septic shock than those with severe sepsis (P<0.01).


CONCLUSIONS
Serum Apelin level changes in patients with severe sepsis and septic shock, which may provide clues in diagnosis and prognosis.
Chen
Xu-Yan
XY
Department of Emergency Medicine, Institute on Cardiovascular Disease Research, Peking University First Hospital, Beijing 100034, China. chenxuyan@medmail.com.cn
Liu
Xin-Min
XM
Feng
Li-Li
LL
Tang
Chao-Shu
CS
D000368:Aged; D000369:Aged, 80 and over; D000073861:Apelin; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000097:blood* / Q000401:mortality / Q000473:pathology; D012772:Shock, Septic / Q000097:blood* / Q000401:mortality / Q000473:pathology; D013997:Time Factors
C115436:APLN protein, human; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins