Iodinated salicylate-based poly(anhydride-esters) as radiopaque biomaterials.
Poly(anhydride-esters) based on iodinated versions of salicylic acid were synthesized via both melt-condensation and solution polymerization techniques to generate radiopaque biomaterials. The poly(anhydride-esters) from iodinated salicylates were highly X-ray opaque compared to poly(anhydride-esters) from salicylic acid. Molecular weight and Young's modulus of polymers prepared by melt-condensation were typically two-to-three times higher than polymers prepared by solution methods. The glass transition temperatures of the polymers were dependent on the iodine concentration; polymers containing more iodine had higher glass transition temperatures. Cytotoxicity studies using mouse fibroblasts indicated that iodinated salicylate-based poly(anhydride-esters) prepared by both polymerization methods are biocompatible with cells at low polymer concentrations (0.01 mg/mL).
Carbone
Ashley L
AL
Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854-8087, USA.
Song
MinJung
M
Uhrich
Kathryn E
KE
D000818:Animals; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers / Q000494:pharmacology; D004952:Esters / Q000737:chemistry / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D054879:Halogenation; D007455:Iodine / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D049388:Polyanhydrides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012459:Salicylates / Q000737:chemistry* / Q000494:pharmacology; D044366:Transition Temperature; D014965:X-Rays
D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D004952:Esters; D049388:Polyanhydrides; D012459:Salicylates; D007455:Iodine