Liver cirrhosis, other liver diseases, and risk of hospitalisation for intracerebral haemorrhage: a Danish population-based case-control study.
BACKGROUND
Liver diseases are suspected risk factors for intracerebral haemorrhage (ICH). We conducted a population-based case-control study to examine risk of ICH among hospitalised patients with liver cirrhosis and other liver diseases.


METHODS
We used data from the hospital discharge registries (1991-2003) and the Civil Registration System in Denmark, to identify 3,522 cases of first-time hospitalisation for ICH and 35,173 sex- and age-matched population controls. Among cases and controls we identified patients with a discharge diagnosis of liver cirrhosis or other liver diseases before the date of ICH. We computed odds ratios for ICH by conditional logistic regressions, adjusting for a number of confounding factors.


RESULTS
There was an increased risk of ICH for patients with alcoholic liver cirrhosis (adjusted OR = 4.8, 95% CI: 2.7-8.3), non-alcoholic liver cirrhosis (adjusted OR = 7.7, 95% CI: 2.0-28.9) and non-cirrhotic alcoholic liver disease (adjusted OR = 5.4, 95%CI:3.1-9.5) but not for patients with non-cirrhotic non-alcoholic liver diseases (adjusted OR = 0.9, 95%CI:0.5-1.6). The highest risk was found among women with liver cirrhosis (OR = 8.9, 95%CI:2.9-26.7) and for patients younger than 70 years (OR = 6.1, 95%CI:3.4-10.9). There were no sex- or age-related differences in the association between other liver diseases (alcoholic or non-alcoholic) and hospitalisation with ICH.


CONCLUSIONS
Patients with liver cirrhosis and non-cirrhotic alcoholic liver disease have a clearly increased risk for ICH.
Grønbaek
Henning
H
Department of Medicine V, Aarhus University Hospital, Denmark. henning.gronbaek@dadlnet.dk
Johnsen
Søren P
SP
Jepsen
Peter
P
Gislum
Mette
M
Vilstrup
Hendrik
H
Tage-Jensen
Ulrik
U
Sørensen
Henrik T
HT
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000209:etiology*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006753:Hospital Records; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000453:epidemiology; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications*; D008107:Liver Diseases / Q000150:complications* / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012042:Registries; D012307:Risk Factors