Association study of the interleukin-1 gene complex and tumor necrosis factor alpha gene with suicide attempts.
To investigate the association between four functional polymorphisms in interleukin-1 (IL-1) [IL-1 alpha -889 C/T, IL-1 beta +3953 C/T, IL-1RA (86 bp)n] and tumor necrosis factor alpha (TNFalpha) (-308A/G) genes and suicide attempts. Distribution of the aforesaid polymorphisms was analyzed in 193 suicide attempters compared with 420 unrelated healthy controls from Asturias (Northern Spain). Genotypes were determined using standard methods. No significant differences were found in genotype or in allelic distribution of IL-1 alpha, IL-1 beta, IL-1RA, or TNFalpha gene polymorphisms. No relationship was found between genotypes and the impulsivity of the suicide attempt. Estimated IL-1 haplotype frequencies were similar in both groups (likelihood ratio test=13.26, df=14, P=0.506). Our data do not suggest that genetically determined changes in the IL-1 or TNFalpha genes confer increased susceptibility to suicidal behavior.
Sáiz
Pilar A
PA
Department of Psychiatry, School of Medicine, University of Oviedo, Julián Clavería, Oviedo, Spain. frank@uniovi.es
García-Portilla
Paz
P
Paredes
Begoña
B
Arango
Celso
C
Morales
Blanca
B
Alvarez
Victoria
V
Coto
Eliécer
E
Bascarán
María-Teresa
MT
Bousoño
Manuel
M
Bobes
Julio
J
D000328:Adult; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D013406:Suicide, Attempted; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha