title: Relationship between rhinitis duration and worsening of nasal function.
abstract: BACKGROUND
  While it is well known that asthma is characterized by airway remodeling, few studies instead have investigated this issue in patients with allergic rhinitis (AR).
  
  
  OBJECTIVE
  The aim of the study was to evaluate nasal function, ie, nasal airflow, in a cohort of patients with persistent AR (PER).
  
  
  METHODS
  One hundred patients, 50 with short-term and 50 with long-term PER, were prospectively and consecutively evaluated, clinically evaluated by visit, skin prick test, and rhinomanometry.
  
  
  RESULTS
  Nasal airflow values were significantly lower (median flow: 348 mL/sec) in patients with long-term rhinitis (median duration nine years) as compared to patients with short-term (median duration one year) rhinitis (median flow: 466 mL/sec) (P < 0.0001).
  
  
  CONCLUSIONS
  This study provides the first evidence that patients with PER may show a progressive worsening of nasal airflow depending on the duration of the disorder.
authors.affiliation: Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy. gio.cip@libero.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Ciprandi
authors.forename: Ignazio
authors.initials: I
authors.lastname: Cirillo
authors.forename: Angela
authors.initials: A
authors.lastname: Pistorio
authors.forename: Stefania
authors.initials: S
authors.lastname: La Grutta
mesh_terms: D000328:Adult; D000403:Airway Resistance / Q000502:physiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009296:Nasal Cavity / Q000503:physiopathology; D015508:Nasal Obstruction / Q000209:etiology / Q000503:physiopathology*; D012119:Respiration; D012221:Rhinitis, Allergic, Perennial / Q000150:complications / Q000503:physiopathology*; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications / Q000503:physiopathology*; D025363:Rhinomanometry; D013997:Time Factors