title: Recurrent hyponatremia after traumatic brain injury.
abstract: Dysregulation of the neuroendocrine system is a frequent complication after traumatic brain injury (TBI). Symptoms of these hormonal abnormalities might be subtle and thus easily ignored. Hyponatremia usually indicates underlying disorders that disrupt fluid homeostasis. In most patients with TBI, hyponatremia is a feature of the syndrome of inappropriate antidiuretic hormone (SIADH) secretion due to pituitary dysfunction after head injury. Usually TBI-associated hyponatremia is transient and reversible. We report the case of a 48-year-old man with TBI-associated hyponatremia with delayed recovery and recurrent hyponatremia precipitated by subsequent surgery. In this report, we emphasize the importance of identifying patients with slow recovery of the injured brain, which could complicate with SIADH and acute hyponatremia. Differentiating TBI-associated SIADH from other important causes of hyponatremia such as cerebral salt wasting, and hypocortisonism are also reviewed. Prevention of its recurrence by avoiding further risk is mandatory in managing patients with TBI.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Taiwan, China.
authors.forename: Chih-Hung
authors.initials: CH
authors.lastname: Chang
authors.forename: Jui-Jung
authors.initials: JJ
authors.lastname: Liao
authors.forename: Chung-Hua
authors.initials: CH
authors.lastname: Chuang
authors.forename: Chien-Te
authors.initials: CT
authors.lastname: Lee
mesh_terms: D001930:Brain Injuries / Q000150:complications*; D006801:Humans; D007010:Hyponatremia / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000150:complications; D008297:Male; D008875:Middle Aged; D012008:Recurrence