title: Novel deprotection method of Fmoc group under neutral hydrogenation conditions.
abstract: Novel deprotection method of the Fmoc (9-flurorenylmethoxycarbonyl) protective group under Pd/C-catalyzed hydrogenation conditions at room temperature was developed. The addition of CH(3)CN accelerated the deprotection of the Fmoc group, and also the application of H(2) pressure (3 atm) shows notable rate enhancement.
authors.affiliation: Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Maegawa
authors.forename: Yuta
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Takashi
authors.initials: T
authors.lastname: Ikawa
authors.forename: Hideo
authors.initials: H
authors.lastname: Hisashi
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Monguchi
authors.forename: Hironao
authors.initials: H
authors.lastname: Sajiki
mesh_terms: D000097:Acetonitriles / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D005449:Fluorenes / Q000138:chemical synthesis / Q000737:chemistry*; D006865:Hydrogenation; D008722:Methods; D010165:Palladium / Q000737:chemistry*
chemical_list: C496789:9-fluorenylmethoxycarbonyl; D000097:Acetonitriles; D000596:Amino Acids; D005449:Fluorenes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D010165:Palladium; C032159:acetonitrile