title: Alterations in mucin expression in ovarian mucinous tumors: immunohistochemical analysis of MUC2, MUC5AC, MUC6, and CD10 expression.
abstract: The aim of this study was to evaluate the immunohistochemical expression of MUC2, MUC5AC, MUC6, and CD10 in ovarian mucinous adenoma (MA), mucinous borderline tumor (MB), and mucinous adenocarcinoma (MC), and to analyze the relationship between prognosis and these expressions. The expression of MUC2, MUC5AC, MUC6, and CD10 was evaluated by immunohistochemical analysis in 29 cases of MA, 29 cases of MB, and 26 cases of MC and scored based on the percentage of positive cells. Moreover, the ovarian mucinous tumors were classified into 4 phenotypes based on the staining patterns: intestinal, gastrointestinal, gastric, and unclassified patterns. The gastrointestinal pattern and the expression of MUC2 and CD10 increased from MA to MC. Conversely, the gastric pattern and MUC5AC expression decreased from MA to MC. Low MUC2 expression in MC was correlated with a better long-term survival rate. MUC2 expression in MC may be a useful predictor of the clinical outcome. The expression patterns of MUC2, MUC5AC, MUC6, and CD10 indicated that intestinal metaplasia may arise from the gastric-like epithelium in MA and that a close association exists between carcinogenesis and intestinal metaplasia in major ovarian mucinous tumors.
authors.affiliation: Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hirabayashi
authors.forename: Masanori
authors.initials: M
authors.lastname: Yasuda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kajiwara
authors.forename: Johbu
authors.initials: J
authors.lastname: Itoh
authors.forename: Masaki
authors.initials: M
authors.lastname: Miyazawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hirasawa
authors.forename: Toshinari
authors.initials: T
authors.lastname: Muramatsu
authors.forename: Masaru
authors.initials: M
authors.lastname: Murakami
authors.forename: Mikio
authors.initials: M
authors.lastname: Mikami
authors.forename: Robert Yoshiyuki
authors.initials: RY
authors.lastname: Osamura