title: Optic neuritis and recurrent myelitis in a woman with systemic lupus erythematosus.
abstract: BACKGROUND
  A 38-year-old woman with systemic lupus erythematosus presented with headaches and bilateral hearing loss. Brain MRI was initially suggestive of small-vessel disease developing in the context of neuropsychiatric systemic lupus erythematosus. Several months later, the patient developed optic neuritis, followed by recurrent attacks of myelitis.
  
  
  METHODS
  MRI of the spine revealed multifocal regions of myelitis affecting the cervical spine. Serological evaluation revealed the presence of neuromyelitis optica-IgG antibodies. MRI of the brain was nondiagnostic for multiple sclerosis.
  
  
  METHODS
  Recurrent myelitis and optic neuritis, occurring in the context of neuromyelitis optica (also known as Devic's syndrome).
  
  
  RESULTS
  The patient had recurrent attacks of myelitis despite treatment with pulse cyclophosphamide. After initiation of rituximab, the patient experienced symptomatic improvement and had no further attacks of opticospinal disease.
authors.affiliation: Division of Rheumatology, The Johns Hopkins University of Medicine, Baltimore, MD 21224, USA. jbirnba2@jhmi.edu
authors.forename: Julius
authors.initials: J
authors.lastname: Birnbaum
authors.forename: Douglas
authors.initials: D
authors.lastname: Kerr
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D001921:Brain / Q000473:pathology; D002574:Cervical Vertebrae / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008279:Magnetic Resonance Imaging; D009471:Neuromyelitis Optica / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D012008:Recurrence; D000069283:Rituximab
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab