title: [Human papillomavirus genotype distribution in invasive squamous cell carcinoma of the uterine cervix in Mongolian women in inner Mongolia autonomy region].
abstract: OBJECTIVE
  To investigate the prevalence of human papillomavirus (HPV) and the HPV genotype distribution in invasive squamous cell carcinoma of the uterine cervix in the Mongolian women in Inner Mongolia autonomy region.
  
  
  METHODS
  The prevalence data of HPV in our department were retrospectively reviewed. INNO-LiPA genotyping technique was used to detect HPV genotypes in the reserved carcinoma tissue specimens.
  
  
  RESULTS
  Totally 63 tissue specimens were collected and detected. The prevalence of HPV was 93.7%. The positive rates of HPV among different clinical staging and different pathological grading were not significantly different (P >0.05). The prevalence of HPV16 was not significantly different among different age groups (P>0.05). HPV16 (69.8%), HPV18 (4.8%), HPV31 (4.8%), HPV39 (4.8%), and HPV52 (3.2%) were the 5 dominating HPV genotypes in all cases.
  
  
  CONCLUSIONS
  HPV infection is closely correlated with invasive squamous cell carcinoma of the uterine cervix in Mongolia women. HPV16 is the most important genotype in invasive squamous cell carcinoma of the uterine cervix, followed by HPV18, 31, and 39. HPV infection dose not affect the progression and differentiation of invasive squamous cell carcinoma of the uterine cervix.
authors.affiliation: Department of Gynecology and Obstetrics, Inner Mongolia Hospital, Hohhot 010017, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Yuan
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Cui
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Xin-Fu
authors.initials: XF
authors.lastname: Liu
authors.forename: Xun
authors.initials: X
authors.lastname: Zhang
authors.forename: Yao
authors.initials: Y
authors.lastname: Cen
authors.forename: Xiu-Rong
authors.initials: XR
authors.lastname: Wang
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: You-Lin
authors.initials: YL
authors.lastname: Qiao
authors.forename: Xian-Zhi
authors.initials: XZ
authors.lastname: Duan
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D005260:Female; D005838:Genotype; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000235:genetics / Q000821:virology; D016133:Polymerase Chain Reaction; D002583:Uterine Cervical Neoplasms / Q000821:virology*