title: Anticomplementary activity of triterpenoids from the whole plant of Aceriphyllum rossii against the classical pathway.
abstract: To provide a better understanding of the anti-complement activity of triterpenoids, seven unusual pentacyclic triterpenoids bearing a carboxyl group at C-27 were evaluated for their anticomplement activities against the classical pathway of the complement system. The triterpenoids were isolated from the whole plant of Aceriphyllum rossii of the family Saxifragaceae and were determined to be 3alpha,23-isopropylidenedioxyolean-12-en-27-oic acid (1), 3-oxoolean-12-en-27-oic acid (2), 3alpha-hydroxyolean-12-en-27-oic acid (3), beta-peltoboykinolic acid (4), 3alpha,23-diacetoxyolean-12-en-27-oic acid (5), 23-hydroxy-3-oxoolean-12-en-27-oic acid (6) and aceriphyllic acid A ( 7). Among them, compounds 2, 3, and 5 showed significant anticomplement activity on the classical pathway with IC (50) values of 71.4, 98.5, and 180.7 microM, respectively, whereas compounds 1, 4, 6, and 7 were inactive. Our findings suggest that both the ketone at C-3 and the methyl at C-23 in the oleanane triterpenoids with a carboxyl group at C-27 are important for the anticomplement activity against the classical pathway.
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongsan, Korea. bsmin@cu.ac.kr
authors.forename: Byung-Sun
authors.initials: BS
authors.lastname: Min
authors.forename: IkSoo
authors.initials: I
authors.lastname: Lee
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Chang
authors.forename: Jae Kuk
authors.initials: JK
authors.lastname: Yoo
authors.forename: MinKyun
authors.initials: M
authors.lastname: Na
authors.forename: Tran Manh
authors.initials: TM
authors.lastname: Hung
authors.forename: Phuong Thien
authors.initials: PT
authors.lastname: Thuong
authors.forename: JongPill
authors.initials: J
authors.lastname: Lee
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Jin Cheol
authors.initials: JC
authors.lastname: Kim
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Woo
authors.forename: Jae Sue
authors.initials: JS
authors.lastname: Choi
authors.forename: Hyeong-Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: KiHwan
authors.initials: K
authors.lastname: Bae
mesh_terms: D003171:Complement Pathway, Classical / Q000187:drug effects*; D003165:Complement System Proteins / Q000378:metabolism; D006801:Humans; D008297:Male; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D053978:Pentacyclic Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D031995:Saxifragaceae / Q000737:chemistry*
chemical_list: D053978:Pentacyclic Triterpenes; D009828:Oleanolic Acid; D003165:Complement System Proteins