title: Immobilized-type chiral packing materials for HPLC based on polysaccharide derivatives.
abstract: The polysaccharide-based chiral packing materials (CPMs) for high-performance liquid chromatography (HPLC) have been recognized as the most powerful ones for the analyzing and preparative separating of the chiral compounds. These CPMs have been conventionally prepared by coating polysaccharide derivatives on a silica gel support. This means that the solvents, which swell or dissolve the derivatives on the silica gel and reduce the performance of the chiral columns, do not allow to be applied as components of the eluents. Therefore, the polysaccharide-based CPMs can be used with a rather limited number of eluents. In order to enhance the versatility of the eluent selection for more practical and economical chromatographic enantioseparations, the polysaccharide derivatives must be immobilized onto the silica gel. This review summarizes our latest studies on the development of the immobilized-type CPMs via the radical copolymerization and the polycondensation of the polysaccharide derivatives bearing small amounts of vinyl groups and alkoxysilyl groups, respectively.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ikai
authors.forename: Chiyo
authors.initials: C
authors.lastname: Yamamoto
authors.forename: Masami
authors.initials: M
authors.lastname: Kamigaito
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Okamoto
mesh_terms: D000688:Amylose / Q000031:analogs & derivatives / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation*; D004364:Pharmaceutical Preparations / Q000302:isolation & purification; D011134:Polysaccharides / Q000737:chemistry*; D013237:Stereoisomerism; D013343:Styrenes / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: D004364:Pharmaceutical Preparations; D011134:Polysaccharides; D013343:Styrenes; D014753:Vinyl Compounds; D002482:Cellulose; D000688:Amylose