Sonographic diagnosis of fetal malformations associated with mycophenolate mofetil exposure in utero.
Mycophenolate mofetil has been shown to have teratogenic properties in animal studies and clinical reports. We report a case of major fetal malformation likely caused by mycophenolate mofetil exposure in utero in a 36 year old patient with systemic lupus erythematosus. The diagnosis was made by ultrasonography at 22 weeks of gestation.
Huang
Shang-Yu
SY
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Chueh
Ho-Yen
HY
Shaw
Sheng-Wen
SW
Shih
Jin-Chung
JC
Cheng
Po-Jen
PJ
D000014:Abnormalities, Drug-Induced / Q000000981:diagnostic imaging*; D000015:Abnormalities, Multiple / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000196:embryology; D000328:Adult; D004431:Ear, External / Q000002:abnormalities; D019066:Facies; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D021621:Imaging, Three-Dimensional; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009666:Nose / Q000002:abnormalities; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D016216:Ultrasonography, Prenatal
D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid