title: The somatosensory cortex in multiple system atrophy.
abstract: In multiple system atrophy (MSA), it has been accepted that the motor-related cortical area may degenerate. However, there have been few investigations of the postcentral cortex of the somatosensory area. For this reason, we investigated the effects of MSA on both the precentral and the postcentral cortex and were able to demonstrate degenerative changes in each. Furthermore, our study showed that degeneration of the postcentral cortex preceded that of the precentral cortex. In addition, we showed that the Betz cells were not selectively lost, but merely depleted like other neurons of the deep cortical layers. Therefore, the effects of MSA are apparently related to selective loss of the small-sized myelinated fibers in the corticospinal tract.
authors.affiliation: Department of Pathology, Tokyo Metropolitan Neurological Hospital, 2-6-1, Musashidai, Fuchu-shi, Tokyo, 183-0042, Japan. mochi@nihon-u.ne.jp
authors.forename: Yoko
authors.initials: Y
authors.lastname: Mochizuki
authors.forename: Toshio
authors.initials: T
authors.lastname: Mizutani
authors.forename: Yoko
authors.initials: Y
authors.lastname: Warabi
authors.forename: Toshio
authors.initials: T
authors.lastname: Shimizu
authors.forename: Eiji
authors.initials: E
authors.lastname: Isozaki
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000473:pathology* / Q000503:physiopathology; D009410:Nerve Degeneration / Q000209:etiology / Q000473:pathology; D013003:Somatosensory Cortex / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D018709:Statistics, Nonparametric; D051844:alpha-Synuclein / Q000378:metabolism; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D005904:Glial Fibrillary Acidic Protein; D051844:alpha-Synuclein; C067980:CD68 antigen, human; D000097382:CD68 Molecule