PDE5 inhibitors for cystic fibrosis: can they also enhance chloride transport? Evaluation of: Lubamba B, Lecourt H, Lebacq J, et al. Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis. Am J Respir Crit Care Med 2008;177(5):506-15.
BACKGROUND
Many compounds are currently under investigation for cystic fibrosis (CF), a genetic disorder caused by various mutations in cystic fibrosis transmembrane regulator (CFTR).


OBJECTIVE
To evaluate a preclinical study on the effects of sildenafil and vardenafil, two PDE5 inhibitors, on ion transport in CF animal models.


RESULTS
The effects of sildenafil and vardenafil on chloride and sodium conductance were assessed in both DeltaF508CFTR and CFTR knockout mice models. They improved chloride transport in the DeltaF508CFTR model and had no effects in the CFTR knockout model.


CONCLUSIONS
Sildenafil and vardenafil are promising agents for CF therapy provided they also demonstrate clinical efficacy.
Antoniu
Sabina A
SA
University of Medicine and Pharmacy Iasi, Pulmonary Disease University Hospital, Division of Pulmonary Disease, 30 Dr I Cihac Street, 700115 Iasi, Romania. sabina.antonela.antoniu@pneum. umfiasi.ro