Serum carbohydrate antigen 125 levels in advanced heart failure: relation to B-type natriuretic peptide and left atrial volume.
OBJECTIVE
To assess the relation between serum levels of carbohydrate antigen 125 (CA 125) and parameters of left ventricular (LV) filling pressure in patients with advanced heart failure (AHF).


METHODS
Forty-nine patients (mean age 67+/-10 years) with LV ejection fraction (EF) < or =0.35 and New York Heart Association (NYHA) class III or IV symptoms of heart failure were enrolled. Left atrial volume indexed to body surface area (LAVI) and the ratio of mitral inflow early diastolic velocity to annulus velocity (E/e) were evaluated with pulsed wave and tissue Doppler. Plasma B-type natriuretic peptide (BNP) was also measured.


RESULTS
The median overall CA 125 value was 44.0 (17.7-140) U/ml. CA 125 above the normal value (<35 U/ml) was found in 28 of the 49 patients (57%). Compared to patients with normal CA 125 levels, those with elevated CA 125 had a higher NYHA class and increased serum BNP levels, LAVI and E/e. In multivariate analysis, serum CA 125 levels were significantly associated with BNP (standardized beta coefficient=0.58, p<0.001) and LAVI (standardized beta coefficient 0.34, p<0.005).


CONCLUSIONS
Our study demonstrates that elevated serum CA 125 levels are associated with increased LAVI in parallel to increased neurohormonal activation in patients with AHF.
Duman
Dursun
D
Haydarpasa Numune Training and Research Hospital, Department of Cardiology, Tibbiye Caddesi, Kadiköy/Istanbul, Turkey. drduman@excite.com
Palit
Fatih
F
Simsek
Ergun
E
Bilgehan
Karadag
K
D000368:Aged; D018394:CA-125 Antigen / Q000097:blood*; D002306:Cardiac Volume / Q000502:physiology*; D015331:Cohort Studies; D005260:Female; D006325:Heart Atria; D006333:Heart Failure / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology*
D018394:CA-125 Antigen; D020097:Natriuretic Peptide, Brain