title: Human T cell development and HIV infection in human hemato-lymphoid system mice.
abstract: Advances in generation of mice that on human hematopoietic stem and progenitor cell transplantation develop and maintain human hemato-lymphoid cells have fueled an already thriving field of research. We focus here on human T cell development and HIV infection in Rag2 -/- gamma(c) -/- mice transplanted as newborns with human CD34+ cord blood hematopoietic stem and progenitor cells.
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Baenziger
authors.forename: P
authors.initials: P
authors.lastname: Ziegler
authors.forename: L
authors.initials: L
authors.lastname: Mazzucchelli
authors.forename: L
authors.initials: L
authors.lastname: Bronz
authors.forename: R F
authors.initials: RF
authors.lastname: Speck
authors.forename: M G
authors.initials: MG
authors.lastname: Manz
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000172:deficiency; D004195:Disease Models, Animal; D015658:HIV Infections / Q000276:immunology*; D006410:Hematopoiesis / Q000502:physiology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D053631:Interleukin Receptor Common gamma Subunit / Q000172:deficiency; D051379:Mice; D016513:Mice, SCID; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology*
chemical_list: D004268:DNA-Binding Proteins; D053631:Interleukin Receptor Common gamma Subunit; C499308:Rag2 protein, mouse