Epigenetic remodeling of the fungal secondary metabolome.
Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules.
Williams
Russell B
RB
Natural Products Discovery Group, Department of Chemistry and Biochemistry, 620 Parrington Oval, Room 208, University of Oklahoma, Norman, Oklahoma 73019-3032, USA. rhcichewicz@ou.edu
Henrikson
Jon C
JC
Hoover
Ashley R
AR
Lee
Andrlynn E
AE
Cichewicz
Robert H
RH
D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D044127:Epigenesis, Genetic; D005658:Fungi / Q000235:genetics / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012335:RNA, Ribosomal / Q000235:genetics; D013056:Spectrophotometry, Ultraviolet
D012335:RNA, Ribosomal; C065096:RNA, ribosomal, 26S