title: Ariakemicins A and B, novel polyketide-peptide antibiotics from a marine gliding bacterium of the genus Rapidithrix.
abstract: Ariakemicins A (1) and B (2), unusual linear hybrid polyketide-nonribosomal peptide antibiotics, were discovered from the fermentation extract of the marine gliding bacterium Rapidithrix sp. These metabolites were positional isomers with regard to a double bond and chromatographically inseparable, rendering the structure study on a mixture basis. The ariakemicins were composed of threonine, two omega-amino-(omega-3)-methyl carboxylic acids with diene or triene units, and delta-isovanilloylbutyric acid. The antibiotics selectively inhibited the growth of Gram-positive bacteria.
authors.affiliation: Applied Bioorganic Chemistry Group, Marine Biotechnology Institute Co Ltd, Kamaishi, Iwate, Japan. noku@riken.jp
authors.forename: Naoya
authors.initials: N
authors.lastname: Oku
authors.forename: Kyoko
authors.initials: K
authors.lastname: Adachi
authors.forename: Satoru
authors.initials: S
authors.lastname: Matsuda
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kasai
authors.forename: Akira
authors.initials: A
authors.lastname: Takatsuki
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Shizuri
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D041963:Bacteroidetes / Q000737:chemistry*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D009842:Oligopeptides; D011090:Polyenes; C530463:ariakemicin A; C530464:ariakemicin B