title: Ultrasonic technology: a new treatment option for anal condylomata acuminata.
abstract: OBJECTIVE
  Treatment options for anal and perianal warts caused by human papillomavirus include topical application of cytotoxic substances or immunomodulators and ablative procedures. The objective of this prospective study was the evaluation of the ultrasound-driven Harmonic Scalpel (Ethicon Endo-Surgery, Norderstedt, Germany) for resection of anal and perianal condylomata acuminata.
  
  
  METHODS
  Eight men and three women (age range, 26-72 years) with anal and perianal condylomata acuminata were treated by a Harmonic Scalpel blade operating at a vibration frequency of 55.5 kHz and within a temperature range of 65 degrees C to 120 degrees C. Nine patients were treatment naïve, and two patients had recurrent disease. Follow-up ranged from 4 to 26 months.
  
  
  RESULTS
  Seven patients had perianal condylomata, two patients had exclusively intra-anal, and two patients had perianal and intra-anal warts. All condylomata were excised in a single-step procedure with complete clearing without injury of subepidermal layers. We observed no intraoperative or postoperative complications. No recurrences occurred during follow-up.
  
  
  CONCLUSIONS
  The Harmonic Scalpel has been an effective and safe method for the treatment of anal perianal human papillomavirus condylomata without recurrent warts. Subepidermal skin levels remained uninjured; thus, no complications or unsatisfactory cosmesis occurred.
authors.affiliation: Department of General and Visceral Surgery, University of Münster, Münster, Germany. m.colombo.benkmann@uni-muenster.de
authors.forename: Mario
authors.initials: M
authors.lastname: Colombo-Benkmann
authors.forename: Dirk
authors.initials: D
authors.lastname: Tübergen
authors.forename: Olaf
authors.initials: O
authors.lastname: Buchweitz
authors.forename: Norbert
authors.initials: N
authors.lastname: Senninger
mesh_terms: D000328:Adult; D000368:Aged; D001004:Anus Diseases / Q000473:pathology / Q000628:therapy*; D002425:Cautery / Q000295:instrumentation*; D003218:Condylomata Acuminata / Q000473:pathology / Q000628:therapy*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000295:instrumentation*