Human T cell development and HIV infection in human hemato-lymphoid system mice.
Advances in generation of mice that on human hematopoietic stem and progenitor cell transplantation develop and maintain human hemato-lymphoid cells have fueled an already thriving field of research. We focus here on human T cell development and HIV infection in Rag2 -/- gamma(c) -/- mice transplanted as newborns with human CD34+ cord blood hematopoietic stem and progenitor cells.
Baenziger
S
S
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.
Ziegler
P
P
Mazzucchelli
L
L
Bronz
L
L
Speck
R F
RF
Manz
M G
MG
D000818:Animals; D004268:DNA-Binding Proteins / Q000172:deficiency; D004195:Disease Models, Animal; D015658:HIV Infections / Q000276:immunology*; D006410:Hematopoiesis / Q000502:physiology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D053631:Interleukin Receptor Common gamma Subunit / Q000172:deficiency; D051379:Mice; D016513:Mice, SCID; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology*
D004268:DNA-Binding Proteins; D053631:Interleukin Receptor Common gamma Subunit; C499308:Rag2 protein, mouse