title: Melorheostosis and FGF-23: is there a relationship?
abstract: Melorheostosis is a rare chronic bone disease of unknown etiology that often affects lower limbs. Onset usually occurs in childhood or early adolescence. The diagnosis relies on the radiographic finding of hyperostosis within or around the cortex responsible for a "flowing wax" appearance. To our knowledge, Fibroblast growth factor-23 (FGF-23) levels have not yet been quantified in melorheostosis. We report an unusual case of this disease for whom the diagnosis of fibrous dysplasia had been wrongly made for a long period of time and the FGF-23 concentration has been found very high without any disturbance of serum phosphate.
authors.affiliation: Départment of Rheumatology, INSERM Research Unit 831 and Lyon University, Pavillon F, Edouard Herriot Hospital, 69437 Lyon Cedex 03, France. samarkerkeni1@yahoo.co.in
authors.forename: Samar
authors.initials: S
authors.lastname: Kerkeni
authors.forename: Roland
authors.initials: R
authors.lastname: Chapurlat
mesh_terms: D000328:Adult; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D007085:Ilium / Q000000981:diagnostic imaging*; D008557:Melorheostosis / Q000097:blood* / Q000000981:diagnostic imaging*; D011859:Radiography
chemical_list: C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23