Biaryl formation from 5-(2-bromobenzyl)-substituted piperidin-2-ones via palladacycles.
The reaction of piperdin-2-ones with a 2-bromobenzyl substituent in the 5-position in the presence of a palladium catalyst leads to biaryl compounds. Their formation can be explained via initial C-H insertion of the aryl palladium species into the allylic C-H bond of the piperidinone. This eventually leads to a metallacycle containing Pd(II) that inserts another aryl bromide, promoting the formation of the biaryl bond.
Satyanarayana
Gedu
G
Institut für Organische Chemie, Universität Tübingen, Tübingen, Germany.
Maier
Martin E
ME