title: Phased array 3D MR spectroscopic imaging of the brain at 7 T.
abstract: Ultra-high-field 7 T magnetic resonance (MR) scanners offer the potential for greatly improved MR spectroscopic imaging due to increased sensitivity and spectral resolution. Prior 7 T human single-voxel MR Spectroscopy (MRS) studies have shown significant increases in signal-to-noise ratio (SNR) and spectral resolution as compared to lower magnetic fields but have not demonstrated the increase in spatial resolution and multivoxel coverage possible with 7 T MR spectroscopic imaging. The goal of this study was to develop specialized radiofrequency (RF) pulses and sequences for three-dimensional (3D) MR spectroscopic imaging (MRSI) at 7 T to address the challenges of increased chemical shift misregistration, B1 power limitations, and increased spectral bandwidth. The new 7 T MRSI sequence was tested in volunteer studies and demonstrated the feasibility of obtaining high-SNR phased-array 3D MRSI from the human brain.
authors.affiliation: Joint UCSF/UC Berkeley Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA 94143, USA. duan@mrsc.ucsf.edu
authors.forename: Duan
authors.initials: D
authors.lastname: Xu
authors.forename: Charles H
authors.initials: CH
authors.lastname: Cunningham
authors.forename: Albert P
authors.initials: AP
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Douglas A C
authors.initials: DA
authors.lastname: Kelley
authors.forename: Pratik
authors.initials: P
authors.lastname: Mukherjee
authors.forename: John M
authors.initials: JM
authors.lastname: Pauly
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Nelson
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Vigneron
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity