title: Insights into the mode of action of the anti-Candida activity of 1,10-phenanthroline and its metal chelates.
abstract: Metal complexes of malonie acid (metal = Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Ag(I)) were prepared and only the Ag(I) complex inhibited the growth of Candida albicans. Malonate complexes incorporating the chelating 1,10-phenanthroline (1,10-phen) ligand showed a range of activities: good (Mn(II), Cu(II), Ag(I)); moderate (Zn(II)); poor (Co(II), Ni(II)). Metal-free 1,10-phen and Ag(CH(3)CO(2)) were also highly active. The metal-free non-chelating ligands 1,7- phenanthroline and 4,7-phenanthroline were inactive and the Cu(II), Mn(II) and Zn(II) complexs of 1,7-phen displayed only marginal activity. Whereas the Cu(II) malonate/1,10-phen complex induces significant cellular oxidative stress the Zn(II) analogue does not.
authors.affiliation: Chemistry Department National University of Ireland Maynooth Maynooth, Co.m Kildare Ireland.
authors.forename: M
authors.initials: M
authors.lastname: McCann
authors.forename: M
authors.initials: M
authors.lastname: Geraghty
authors.forename: M
authors.initials: M
authors.lastname: Devereux
authors.forename: D
authors.initials: D
authors.lastname: O'Shea
authors.forename: J
authors.initials: J
authors.lastname: Mason
authors.forename: L
authors.initials: L
authors.lastname: O'Sullivan