Nonsense-mediated mRNA decay.
Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes premature from normal translation termination? Surprisingly, in mammalian cells, PTC recognition is linked to pre-mRNA splicing. Here, we review the current understanding in view of recent developments.
Wen
Jikai
J
School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Brogna
Saverio
S
D017398:Alternative Splicing; D000818:Animals; D018389:Codon, Nonsense / Q000378:metabolism*; D005091:Exons / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D008957:Models, Genetic; D020871:RNA Stability
D018389:Codon, Nonsense