title: (1-nosyl-5-nitroindol-3-yl)methyl ester: a novel protective group for carboxylic acids.
abstract: The usefulness of (1-nosyl-5-nitroindol-3-yl)methyl esters as a novel protective group for carboxylic acid is fully demonstrated. The novel protective group is stable under a broad range of conditions and can easily be deprotected under the mild conditions used for removal of the nosyl (Ns) group. It is orthogonal to the existing protective groups for carboxylic acids such as t-butyl and allyl esters.
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Nishimura
authors.forename: Kouhei
authors.initials: K
authors.lastname: Yamada
authors.forename: Tohru
authors.initials: T
authors.lastname: Takebe
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yokoshima
authors.forename: Tohru
authors.initials: T
authors.lastname: Fukuyama
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D004952:Esters; D007211:Indoles; D009574:Nitro Compounds