Poor outcomes of chronic active Epstein-Barr virus infection and hemophagocytic lymphohistiocytosis in non-Japanese adult patients.
Chronic active Epstein-Barr virus infection manifests as a combination of persistent infectious mononucleosis-like symptoms and high viral load in apparently immunocompetent patients. It is closely related to Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. These 2 abnormal Epstein-Barr virus-associated diseases are seldom reported in individuals other than Japanese children and adolescents. We report a series of 2 adult non-Japanese patients with fatal chronic active Epstein-Barr virus and 1 adult non-Japanese patient with Epstein-Barr virus hemophagocytic lymphohistiocytosis and discuss its pathogenesis and treatment options.
Sonke
Gabe S
GS
Departments of 1Medical Oncology and 2Pathology, Antoni van Leeuwenhoek Hospital-Netherlands Cancer Institute, 1006 BE Amsterdam, The Netherlands. g.sonke@nki.nl
Ludwig
Inge
I
van Oosten
Hannah
H
Baars
Joke W
JW
Meijer
Ellen
E
Kater
Arnon P
AP
de Jong
Daphne
D
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D020031:Epstein-Barr Virus Infections / Q000401:mortality* / Q000473:pathology / Q000628:therapy / Q000821:virology; D017809:Fatal Outcome; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000401:mortality* / Q000473:pathology / Q000628:therapy / Q000821:virology; D008297:Male; D008875:Middle Aged; D019562:Viral Load
D000914:Antibodies, Viral