title: Diverse functions of WD40 repeat proteins in histone recognition.
abstract: WD40 repeat proteins have been shown to bind the histone H3 tail at the center of their beta-propeller structure. In contrast, in this issue of Genes & Development, Song and colleagues (pp. 1313-1318) demonstrate that the WD40 repeat protein p55 binds a structured region of H4 through a novel binding pocket on the side of beta-propeller, illustrating a diversity of histone recognition by WD40 repeat proteins.
authors.affiliation: Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
authors.forename: Tamaki
authors.initials: T
authors.lastname: Suganuma
authors.forename: Samantha G
authors.initials: SG
authors.lastname: Pattenden
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Workman
mesh_terms: D000818:Animals; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D020449:Repetitive Sequences, Amino Acid / Q000502:physiology*
chemical_list: D006657:Histones; D011506:Proteins