Ergotamine-derived dopamine agonists and left ventricular function in Parkinson patients: systolic and diastolic function studied by conventional echocardiography, tissue Doppler imaging, and two-dimensional speckle tracking.
OBJECTIVE
Ergot-derived dopamine agonists (EDDA) induce fibrotic heart valve disease. We aimed to investigate whether EDDA treatment also affects left ventricular (LV) function.


RESULTS
Myocardial function was evaluated in 110 Parkinson patients [mean age (63.4 +/- 9.0 years)] treated for at least 6 months with either EDDA (n = 71) or non-EDDA (n = 39). LV ejection fraction did not differ between EDDA and non-EDDA patients [63 +/- 4% vs. 65 +/- 4% (ns)]. There was no difference in prevalence of diastolic dysfunction between EDDA and non-EDDA patients [7% vs. 8% (ns)]. Finally, averaged LV systolic myocardial strain and longitudinal displacement analysed by means of two-dimensional speckle tracking showed no difference between EDDA and non-EDDA patients [strain: 19 +/- 3% vs. 19 +/- 2% (ns) and longitudinal displacement: 12 +/- 2 mm vs. 12 +/- 2 mm (ns)]. Elevated p-NT-proBNP was found in 38% of EDDA patients and in 59% of non-EDDA patients (ns).


CONCLUSIONS
In contrast to the well-established association between EDDA treatment and valvular fibrosis, EDDA did not have a detectable adverse impact on myocardial systolic and diastolic function.
Rasmussen
Vibeke Guldbrand
VG
Department of Cardiology, Aarhus University Hospital, Skejby, DK-8200 Aarhus N, Denmark.
Poulsen
Steen Hvitfeldt
SH
Dupont
Erik
E
Ostergaard
Karen
K
Safikhany
Gholamhossein
G
Egeblad
Henrik
H
D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D003971:Diastole; D018491:Dopamine Agonists / Q000009:adverse effects* / Q000627:therapeutic use; D004452:Echocardiography / Q000379:methods*; D018619:Echocardiography, Doppler, Pulsed; D004878:Ergotamine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010300:Parkinson Disease / Q000097:blood / Q000000981:diagnostic imaging* / Q000188:drug therapy; D012189:Retrospective Studies; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging; D016277:Ventricular Function, Left / Q000187:drug effects
D015415:Biomarkers; D018491:Dopamine Agonists; D020097:Natriuretic Peptide, Brain; D004878:Ergotamine