Characterization of adult onset growth hormone deficiency syndrome in patients with hypothalamopituitary diseases: Asian Indian data.
BACKGROUND
Hardly any data is available on Adult onset growth hormone deficiency (AOGHD) in Patients with hypothalamopituitary diseases in India.


OBJECTIVE
To characterize Asian Indian AOGHD syndrome in hypothalamopituitary diseases.


METHODS
Cross-sectional analysis of data from a tertiary care hospital.


METHODS
Thirty patients with AOGHD were compared with 30 age-, sex-, body mass index-matched controls with respect to endocrine evaluation, biochemistry, body composition (BC), bone mineral density (BMD), cardiovascular risk profile and quality of life (QoL).


METHODS
Comparisons were performed using two-tailed Student's test (SPSS Software version 10.0).


RESULTS
Most of the patients had abnormal BC with central obesity [Truncal FM (%): males {33.9+/-4.4 (patient) vs. 29.31+/-6.2 (control); P -0.027}; females {39.87+/-5.93 (patient) vs. 35.76+/-3.16 (control); P - 0.025}] and poor QoL. Patients aged over 45 years did not show low bone mass or lipid abnormalities as compared to controls. Low BMD and abnormal lipid profile {Triglycerides [mg/dl]:170.55+/-72.5 (patient) vs101.24+/-31.0 (control); P -0.038}; {very low density lipoprotein cholesterol [mg/dl]: 33.54+/-14.9 (patient) vs. 20.25+/-6.18 (control); P - 0.05} was seen in female patients less than 45 years of age.


CONCLUSIONS
Male and female (more than 45 years) AOGHD patients have increased cardiovascular risk factors and poor QoL while BMD is unaffected. Females less than 45 years of age have the major characteristics of AOGHD and would be the group to benefit maximally with recombinant human Growth Hormone treatment, which is similar to that in the western literature.
Bandgar
T R
TR
Department of Endocrinology, Seth G S Medical College and K E M Hospital, Parel, Mumbai, India. drtusharb@gmail.com
Prashanth
M
M
Joshi
S R
SR
Menon
P S
PS
Shah
N S
NS
D000328:Adult; D017668:Age of Onset; D044466:Asian People; D001823:Body Composition; D015519:Bone Density; D002318:Cardiovascular Diseases; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D019382:Human Growth Hormone / Q000097:blood* / Q000172:deficiency*; D006801:Humans; D007027:Hypothalamic Diseases / Q000208:ethnology / Q000378:metabolism*; D007194:India; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010900:Pituitary Diseases / Q000208:ethnology / Q000378:metabolism*; D011788:Quality of Life; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013577:Syndrome
D008055:Lipids; D019382:Human Growth Hormone