Lipoxins: update and impact of endogenous pro-resolution lipid mediators.
Lipoxins (LXs) are endogenously produced eicosanoids that are typically generated by transcellular biosynthesis. These trihydroxytetraene-containing lipid mediators and their stable synthetic analogues possess a wide spectrum of anti-inflammatory and pro-resolution bioactions both in vitro and in vivo. More recently, LXs have emerged as potential anti-fibrotic mediators that may influence pro-fibrotic cytokines and matrix-associated gene expression in response to platelet-derived growth factor (PDGF). Here we review the biosynthesis, metabolism and bioactions of LXs and LX analogues and their therapeutic potential.
O'Meara
S J
SJ
UCD Conway Institute of Biomolecular and Biomedical Research and UCB Diabetes Research Center, School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin 4, Ireland.
Rodgers
K
K
Godson
C
C
D000818:Animals; D004194:Disease; D006801:Humans; D050356:Lipid Metabolism; D044045:Lipoxins / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction
D044045:Lipoxins