[The Na+,K+ pump continues to cause surprise].
This article provides an overview of news about the Na+,K+ pump, an indispensable enzyme whose protein structure has been described in a recent article in Nature, 50 years after its discovery. In combination with mutational analysis, the structure reveals the binding pocket for the K+ ions and the regulation of Na+ transport by a strategically located C-terminus of the protein. Focus is also on the pathophysiology of two neurological disorders, familial hemiplegic migraine and rapid-onset dystonia-parkinsonism, recently shown to be caused by mutations in the Na+,K+-ATPase.
Vilsen
Bente
B
Aarhus Universitet, Institut for Fysiologi og Biofysik, Arhus C. bv@fi.au.dk
D004421:Dystonia / Q000201:enzymology / Q000235:genetics; D006801:Humans; D020325:Migraine with Aura / Q000201:enzymology / Q000235:genetics; D015394:Molecular Structure; D009154:Mutation; D020734:Parkinsonian Disorders / Q000201:enzymology / Q000235:genetics; D000254:Sodium-Potassium-Exchanging ATPase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D000254:Sodium-Potassium-Exchanging ATPase