title: A case of livedoid vasculopathy associated with factor V Leiden mutation: successful treatment with oral warfarin.
abstract: Livedoid vasculopathy is characterized by painful purpuric lesions on the extremities which frequently ulcerate and heal with atrophic scarring. It has been considered to be a vasculitic process but now there has been increasing evidence that abnormal coagulation plays a major role in the pathogenesis of this rare disorder. We report the case of a 19-year-old male who had been suffering from recurrent painful ulcerations on both lower legs with atrophic scars for 4 years. A biopsy specimen revealed vasculopathy, and laboratory studies showed resistance to activated protein C with factor V Leiden mutation. Treatment with oral warfarin led to rapid improvement of the lesions.
authors.affiliation: Goztepe Training and Research Hospital, Department of Dermatology, Istanbul, Turkey.
authors.forename: Mukaddes
authors.initials: M
authors.lastname: Kavala
authors.forename: Emek
authors.initials: E
authors.lastname: Kocaturk
authors.forename: Ilkin
authors.initials: I
authors.lastname: Zindanci
authors.forename: Zafer
authors.initials: Z
authors.lastname: Turkoglu
authors.forename: Sumeyye
authors.initials: S
authors.lastname: Altintas
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage*; D005165:Factor V / Q000235:genetics*; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D008297:Male; D009154:Mutation / Q000235:genetics*; D017445:Skin Diseases, Vascular / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D014859:Warfarin / Q000008:administration & dosage*
chemical_list: D000925:Anticoagulants; C095381:factor V Leiden; D014859:Warfarin; D005165:Factor V