title: Experimental study of nano-HA artificial bone with different pore sizes for repairing the radial defect.
abstract: The purpose of this study was to examine the repairing ability of nano-hydroxyapatite (nano-HA) artificial bone with different pore sizes. Animal models of bone defects were created in both radii of 60 New Zealand white rabbits. The bone defects in A, B, and C groups were repaired with nano-HA artificial bone with three different pore sizes while those in group D were left unrepaired. The repairing ability of material was evaluated by gross observation, histopathological study, X-ray examination, scanning electron microscope (SEM), and biomechanical analysis in the fourth, eighth, and 12th weeks. Group B stimulated more bone formation than the other groups. Nano-HA artificial bone is capable of good bone formation and biocompatibility. The ability of bone formation of nano-HA artificial bone may be affected significantly by the pore size. The material with pore size in the range of 100 -250 microm has a greater ability to form bone.
authors.affiliation: Department of Traumatic Orthopaedics, Shenzhen Second People's Hospital, Shenzhen, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Zhu
authors.forename: Jiande
authors.initials: J
authors.lastname: Xiao
authors.forename: Daping
authors.initials: D
authors.lastname: Wang
authors.forename: Jianquan
authors.initials: J
authors.lastname: Liu
authors.forename: Jianyi
authors.initials: J
authors.lastname: Xiong
authors.forename: Lijun
authors.initials: L
authors.lastname: Liu
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhang
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D001696:Biomechanical Phenomena; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology*; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005592:Fracture Fixation / Q000379:methods*; D017102:Fracture Healing / Q000502:physiology; D006882:Hydroxyapatites / Q000627:therapeutic use*; D016062:Porosity; D011336:Probability; D011817:Rabbits; D011859:Radiography; D011885:Radius Fractures / Q000000981:diagnostic imaging* / Q000601:surgery*; D011897:Random Allocation; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D006882:Hydroxyapatites