title: The use of Affymetrix GeneChips as a tool for studying alternative forms of RNA.
abstract: We are developing a computational pipeline to use surveys of Affymetrix GeneChips as a discovery tool for unravelling some of the biology associated with post-transcriptional processing of RNA. This work involves the integration of a number of bioinformatics resources, from comparing annotations to processing images to determining the structure of transcripts. The rapidly growing datasets of GeneChips available to the community puts us in a strong position to discover novel biology about post-transcriptional processing, and should enable us to determine the mechanisms by which some groups of genes make co-ordinated changes in their production of isoforms.
authors.affiliation: Departments of Biological Sciences and Mathematical Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK. harry@essex.ac.uk
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Harrison
authors.forename: Joanna
authors.initials: J
authors.lastname: Rowsell
authors.forename: Renata
authors.initials: R
authors.lastname: da Silva Camargo
authors.forename: William B
authors.initials: WB
authors.lastname: Langdon
authors.forename: Maria
authors.initials: M
authors.lastname: Stalteri
authors.forename: Graham J G
authors.initials: GJ
authors.lastname: Upton
authors.forename: Jose M
authors.initials: JM
authors.lastname: Arteaga-Salas
mesh_terms: D017398:Alternative Splicing / Q000235:genetics; D000818:Animals; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D026723:Polyadenylation; D012313:RNA / Q000378:metabolism*
chemical_list: D012313:RNA