[Disturbed microvascular permeability in the eye caused by capsaicin microinjections into the trigeminal caudalis nucleus].
Capsaicin microinjection into the trigeminal caudalis nucleus (the central projection area of trigeminal capsaicin-sensitive nerve) increase extravasation of proteins in rat eye. The effect was inhibited by ruthenium red introduction (a capsaicin receptor antagonist) and by blocking the effector functions of capsaicin-sensitive nerve endings. It is suggested that capsaicin stimulation of central terminations of trigeminal capsaicin-sensitive afferents induce an increase in the microvascular permeability of the eye, which is mediated through the effector function of capsaicin-sensitive nerves.
Tolochko
Z S
ZS
Spiridonov
V K
VK
D000818:Animals; D002199:Capillary Permeability; D002211:Capsaicin / Q000008:administration & dosage / Q000494:pharmacology*; D005123:Eye / Q000098:blood supply* / Q000294:innervation; D008297:Male; D008845:Microinjections; D051381:Rats; D017208:Rats, Wistar; D014275:Trigeminal Caudal Nucleus / Q000502:physiology*
D002211:Capsaicin