In vivo anti-inflammatory effect of a new steroidal saponin, mannioside A, and its derivatives isolated from Dracaena mannii.
A new steroidal saponin, mannioside A (1), was isolated from the stem bark of Dracaena mannii, together with the known pennogenin (2), pennogenin-3-O-beta-D-glucopyranoside (3) and pennogenin-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->3)]-beta-D-glucopyranoside (4). Their structures were determined using 1D-and 2D-NMR spectroscopy and mass spectrometry. Compounds 1 and 3 significantly inhibited carrageenan-induced paw edema in the rat; compound 4 was moderately active whereas 2 showed very weak activity.
Tapondjou
Leon Azefack
LA
Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Ponou
Kemvoufo Beaudelaire
KB
Teponno
Remy Bertrand
RB
Mbiantcha
Marius
M
Djoukeng
Jules Désiré
JD
Nguelefack
Télesphore Benoit
TB
Watcho
Pierre
P
Cadenas
Aurelio Gomez
AG
Park
Hee-Juhn
HJ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002351:Carrageenan; D031409:Dracaena; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D008297:Male; D008362:Mannosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008362:Mannosides; D010936:Plant Extracts; D012503:Saponins; C530810:pennogenin-3-O-rhamnopyranosyl-1-3-glucopyranoside; D002351:Carrageenan