A pilot case-control association study of cytokine polymorphisms in Brazilian women presenting with HPV-related cervical lesions.
OBJECTIVE
A case-control study was conducted on 42 Brazilian women presenting with human papilloma virus (HPV) infection and cervical lesion and 87 HPV-negative women to evaluate single nucleotide polymorphisms observed in TNF-alpha, TGF-beta, IL-10, IL-6, and IFN-gamma genes.


CONCLUSIONS
No significant association was observed on the cytokine polymorphisms analyzed in this series. Larger studies using cytokine polymorphisms may be useful for providing further information regarding their influence or not in HPV-related cervical lesions.
Fernandes
Ana Paula M
AP
Department of General and Specialized Nursing, Nursing School of Ribeirão Preto, University of São Paulo, Brazil.
Gonçalves
Maria Alice G
MA
Simões
Renata T
RT
Mendes-Junior
Celso T
CT
Duarte
Geraldo
G
Donadi
Eduardo A
EA
D000293:Adolescent; D000328:Adult; D001938:Brazil; D016022:Case-Control Studies; D016207:Cytokines / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000821:virology; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000821:virology
D016207:Cytokines