Experimental infection of calves with Newcastle disease virus induces systemic and mucosal antibody responses.
Calves were infected intranasally and intratracheally with Newcastle disease virus (NDV), an avian paramyxovirus. Clinical signs, viral replication, and antibody production were evaluated. This study showed that NDV replicated in calves, as evidenced by development of NDV-specific humoral and mucosal antibody responses, but was attenuated in this unnatural host. These results suggest that NDV has the potential for development as a host-range-restricted, intranasal vaccine vector for cattle that lack preexisting immunity to NDV.
Subbiah
Madhuri
M
Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA.
Yan
Yongqi
Y
Rockemann
Daniel
D
Samal
Siba K
SK
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis* / Q000097:blood / Q000276:immunology; D000918:Antibody Specificity; D002417:Cattle; D009297:Nasal Mucosa / Q000276:immunology*; D009521:Newcastle Disease / Q000097:blood / Q000276:immunology* / Q000821:virology; D009522:Newcastle disease virus / Q000276:immunology
D000914:Antibodies, Viral