title: New cytotoxic diarylheptanoids from the rhizomes of Alpinia officinarum.
abstract: Bioassay-guided fractionation of the cytotoxic MeOH extract from the rhizomes of Alpinia officinarum Hance led to the isolation of two new diarylheptanoids named alpinoid D (1) and E (2), together with fifteen known diarylheptanoids (3 - 17). The structures of compounds 1 and 2 were elucidated on the basis of spectroscopic data and chemical evidence. The cytotoxic activity of the isolated diarylheptanoids was evaluated against the IMR-32 human neuroblastoma cell line. Among the tested compounds, 11, 12 and 14 exhibited the most potent activities with IC (50) values of 0.83, 0.23 and 0.11 microM, respectively.
authors.affiliation: College of Pharmacy, Nihon University, Chiba, Japan.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Keiichi
authors.initials: K
authors.lastname: Tabata
authors.forename: Hideki
authors.initials: H
authors.lastname: Matsubara
authors.forename: Susumu
authors.initials: S
authors.lastname: Kitanaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Ken
authors.initials: K
authors.lastname: Yasukawa
mesh_terms: D032429:Alpinia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D036381:Diarylheptanoids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009447:Neuroblastoma / Q000188:drug therapy; D027343:Rhizome / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D036381:Diarylheptanoids