title: Cornification defect in the golden retriever: clinical, histopathological, ultrastructural and genetic characterisation.
abstract: Veterinarians have recognised a nonpruritic skin disease in the Golden retriever breed characterised by excessive scaling of large, variably pigmented flakes of skin in otherwise healthy dogs. This prospective case series describes clinical, histopathological, ultrastructural and genetic features of this cornification defect in 17 affected dogs. The condition affects young dogs of either sex and is characterised by symmetrical, predominantly ventro-lateral scaling and hyperpigmentation of the trunk. Histopathological and ultrastructural changes of the stratum corneum are suggestive of delayed degradation of corneodesmosomes. A genetic aetiology is proposed and a single-trait autosomal recessive mode of inheritance discussed.
authors.affiliation: Department of Veterinary Clinical Sciences, Royal Veterinary College, North Mymms, Hatfield, Herts, UK.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Cadiergues
authors.forename: Anita
authors.initials: A
authors.lastname: Patel
authors.forename: David H
authors.initials: DH
authors.lastname: Shearer
authors.forename: Ruth
authors.initials: R
authors.lastname: Fermor
authors.forename: Suhel
authors.initials: S
authors.lastname: Miah
authors.forename: Anke
authors.initials: A
authors.lastname: Hendricks
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000235:genetics* / Q000473:pathology*; D004285:Dogs; D005260:Female; D020022:Genetic Predisposition to Disease; D017495:Hyperpigmentation / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000662:veterinary; D010375:Pedigree; D011446:Prospective Studies; D012867:Skin / Q000473:pathology* / Q000648:ultrastructure; D012871:Skin Diseases / Q000235:genetics / Q000473:pathology / Q000662:veterinary*