title: Ascochytatin, a novel bioactive spirodioxynaphthalene metabolite produced by the marine-derived fungus, Ascochyta sp. NGB4.
abstract: Ascochytatin, a new spirodioxynaphthalene metabolite produced by a marine-derived fungus, was found from a screening program focused on the bacterial two-component regulatory system. The structure of ascochytatin was determined by spectroscopic methods, including NMR and MS. The relative stereochemistry was determined by an X-ray crystallographic analysis, and the absolute stereochemistry was determined by the modified Mosher's method.
authors.affiliation: Marine Biotechnology Institute Co., Ltd, Kamaishi, Iwate, Japan. kaneo.kanoh@mbio.jp
authors.forename: Kaneo
authors.initials: K
authors.lastname: Kanoh
authors.forename: Ario
authors.initials: A
authors.lastname: Okada
authors.forename: Kyoko
authors.initials: K
authors.lastname: Adachi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imagawa
authors.forename: Mugio
authors.initials: M
authors.lastname: Nishizawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Matsuda
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Shizuri
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Utsumi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry* / Q000145:classification; D001412:Bacillus subtilis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D018360:Crystallography, X-Ray; D003470:Culture Media; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D009281:Naphthalenes; D013141:Spiro Compounds; C532325:ascochytatin