title: [Formulation of an oral solid dosage form containing human interferon-alpha].
abstract: The main objective of this study was to process the human alpha-interferon for the solid dosage form. The first step was the preparation of the intermediate product for the tablet making. Fluid bed apparatus with top spray method was applied for the layering of powdered cellulose with human alpha-interferon solutions. The intermediate product was compressed into tablet and an enteric solvent coating of the tablets was made in a fluid bed apparatus with Wurster method. The physical parameters were detected. These fitted the Ph. Eur. and the mechanical properties of the tablets were appropriate for coating in fluid bed apparatus. The tablets agree with the requirements of Ph. Eur. and the active agent was not dissolved in gastric juice. An animal test was also performed. The human alpha-interferon in the blood of the animals was detected with ELISA method. The human alpha-interferon specific kit was used. The active ingredient dissolved from the tablets was absorbed from the ileum. The solid dosage form containing human alpha-interferon was prepared; this can make oral application of human alpha-interferon possible.
authors.affiliation: Szegedi Tudományegyetem, Gyógyszertechnológiai Intézet, Szeged, Eötvös u. 6. - 6720.
authors.forename: Katalin
authors.initials: K
authors.lastname: Kristo
authors.forename: János
authors.initials: J
authors.lastname: Bajdik
authors.forename: Arpád
authors.initials: A
authors.lastname: Márki
authors.forename: István
authors.initials: I
authors.lastname: Eros
authors.forename: György
authors.initials: G
authors.lastname: Falkay
authors.forename: Klára
authors.initials: K
authors.lastname: Hödi
mesh_terms: D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage*; D007700:Kinetics; D013607:Tablets
chemical_list: D004304:Dosage Forms; D016898:Interferon-alpha; D013607:Tablets