title: Synthesis and antidiabetic activity of some new thiazolyl-2,4-thiazolidinediones.
abstract: In this study, a series of thiazolyl-2,4-thiazolidinediones (VIa-f, VIHa-f and VIIa-f) was prepared by Knoevenagel reaction of substituted phenacyl-2,4-thiazolidinediones (IVa-f)/substituted benzyl-2,4-thiazolidinediones (Va-f) with chlorothiazolecarbaldehydes (II, III). The prepared compounds were tested for their insulinotropic activities in INS-1 cells. A significant insulinotropic effect was seen with compounds VIa, VIb, VIe, VIIa, VIIb and VIIId. Introducing a 2-[(phenylethyl)thio] group into the thiazole ring increased the biological effect, whereas NO2 groups in phenylacyl or benzyl groups diminished the effects.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandoğan, Ankara, Turkey. bozdag@pharmacy.ankara.edu.tr
authors.forename: Oya
authors.initials: O
authors.lastname: Bozdağ-Dündar
authors.forename: Arzu
authors.initials: A
authors.lastname: Menteşe
authors.forename: Eugen J
authors.initials: EJ
authors.lastname: Verspohl
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005947:Glucose / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007328:Insulin / Q000378:metabolism; D051381:Rats; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D007004:Hypoglycemic Agents; D007202:Indicators and Reagents; D007328:Insulin; D045162:Thiazolidinediones; D005947:Glucose