Glioma extent of resection and its impact on patient outcome.
OBJECTIVE
There is still no general consensus in the literature regarding the role of extent of glioma resection in improving patient outcome. Although the importance of resection in obtaining tissue diagnosis and alleviating symptoms is clear, a lack of Class I evidence prevents similar certainty in assessing the influence of extent of resection.


METHODS
We reviewed every major clinical publication since 1990 on the role of extent of resection in glioma outcome.


RESULTS
Twenty-eight high-grade glioma articles and 10 low-grade glioma articles were examined in terms of quality of evidence, expected extent of resection, and survival benefit.


CONCLUSIONS
Despite persistent limitations in the quality of data, mounting evidence suggests that more extensive surgical resection is associated with longer life expectancy for both low- and high-grade gliomas.
Sanai
Nader
N
Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA. sanain@neurosurg.ucsf.edu
Berger
Mitchel S
MS
D001932:Brain Neoplasms / Q000401:mortality* / Q000601:surgery*; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D005910:Glioma / Q000401:mortality* / Q000601:surgery*; D006801:Humans; D015994:Incidence; D008017:Life Expectancy; D019635:Neurosurgical Procedures / Q000401:mortality*; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome