title: Mannan-binding lectin levels related to spontaneous abortion in Brazilian patients with celiac disease.
abstract: Low concentration of mannan-binding lectin (MBL) has been related to unexplained spontaneous abortion (SA), which has also been observed in an increased frequency in patients with celiac disease (CD). In this study, plasma levels of MBL were determined in patients with CD and irritable bowel syndrome (IBS) in order to investigate whether there is an association of MBL levels and the occurrence of SA in these patients. MBL concentration was determined in 46 patients with CD (28 without and 18 with report of SA) and 38 patients with IBS (25 without and 13 with report of SA). A higher frequency of SA was observed in women with CD when compared to IBS patients (23.2 vs. 13.9%; P = 0.046). No significant difference was observed in MBL concentrations between patients with CD, IBS, and healthy controls, nor between patients with or without occurrence of SA. These results suggest that the serum levels of MBL and the occurrence of SA in women with CD and IBS are not causally related.
authors.affiliation: Gastroenterology Service, Cajuru Hospital, Pontifical Catholic University of Paraná, Curitiba, Parana, Brazil.
authors.forename: Lorete Maria
authors.initials: LM
authors.lastname: da Silva Kotze
authors.forename: Elisandra Grangeiro
authors.initials: EG
authors.lastname: de Carvalho
authors.forename: Shirley Ramos
authors.initials: SR
authors.lastname: da Rosa Utiyama
authors.forename: Renato Mitsunori
authors.initials: RM
authors.lastname: Nisihara
authors.forename: Iara
authors.initials: I
authors.lastname: Messias-Reason
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D016022:Case-Control Studies; D002446:Celiac Disease / Q000097:blood*; D005260:Female; D006306:Health Surveys; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000097:blood; D037601:Mannose-Binding Lectin / Q000097:blood*; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D037601:Mannose-Binding Lectin