[Study on a 10-year protective effects of vaccination against hemorrhagic fever with renal syndrome].
OBJECTIVE
To evaluate the epidemiological and serological efficacy after 10 years of vaccination against hemorrhagic fever with renal syndrome (HFRS) vaccines in Zhejiang province.


METHODS
One county was randomly chosen as the research unit with all the healthy people between 16 and 60 years old were equally divided into study and control groups. The study group was vaccinated. Immunofluorescent antibody assay was used to test specific IgG antibody and Mcro-CPE method was used to test the titer of neutralizing antibody.


RESULTS
Two weeks after the full-course immunization, the seroconversion rate became 100% (67/67, with 95% CI as 96.3%-100%) by immunofluorescent antibody test (IgG) and 44.4% (8/18 with 95% CI as 22.0%-69.0%) by neutralization test with GMT titers as 72.1 and 4.6 respectively. Booster immunization was provided one year later. Time span as two weeks prior to, one year, one and half years, two years, three years and five years after booster immunization, the rates of seroconversion on immunofluorescent antibody using IFAT method, were 28.6%, 83.3%, 75.0%, 53.1%, 22.6%, 10.0% and 55.0% respectively, and rates of seroconversion of neutralizing antibody by Mcro-CPE method were 14.8%, 55.6%, 35.0%, 31.3%, 26.0%, 10.0% and 50.0% respectively. Nine years after the reinforcement, the rates of seroconversion of immunofluorescent antibody by IFAT method was only 7.1%. The vaccinated group had no patient seen but the control group appeared 34 patients including 3 deaths. According to the ten-year observation, the vaccine seemed effective with the protection rate in population reached 100%.


CONCLUSIONS
HFRS vaccine was effective on epidemiological, social and economical efficacy.
Gong
Zhen-Yu
ZY
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310009, China.
Weng
Jing-Qing
JQ
Lei
Jin-Bao
JB
Fang
Chun-Fu
CF
Chen
En-Fu
EF
Wang
Zhen
Z
Chen
Zhong-Bing
ZB
Wang
Wei
W
He
Fan
F
Liu
Bi-Yao
BY
Lin
Jun-Fen
JF
Ding
Gang-Qiang
GQ
D000293:Adolescent; D000328:Adult; D000818:Animals; D005260:Female; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods; D008297:Male; D008875:Middle Aged; D051381:Rats; D014611:Vaccination / Q000379:methods*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000627:therapeutic use; D055815:Young Adult
D014765:Viral Vaccines