title: Hormone receptor-related gene polymorphisms and prostate cancer risk in North Indian population.
abstract: The purpose of this study was to analyse the frequency and type of mutations in the coding region of androgen receptor (AR) and to determine the role of polymorphisms in the intron 1 of ERalpha, exon 5 of ERbeta, intron 7 of progesterone, exon 7 of the aromatase (CYP19) and exon 9 of VDR genes in the risk of prostate cancer. PCR-RFLP analysis of all above the genes was on 100 prostate cancer patients and an equal number of matching controls. The study also included PCR-SSCP analyses of exons 2-8 of AR gene. The genotype containing -/- allele of ERalpha gene was statistically significant for the risk of prostate cancer pose (OR, 2.70; 95% CI, 1.08-6.70, P = 0.032) Rr genotype of ERbeta gene also have a higher risk (OR, 1.65; 95% CI, 0.52-5.23) for prostate cancer. The Cys allele of CYP19 gene was also associated with statistically significant increased risk of prostate cancer (OR; 2.28, 95% CI, 1.20-4.35, P = 0.012). tt genotype of codon 352 of VDR gene showed an OR of 0.43 for (95% CI, 0.13-1.39) and an OR for Tt genotype was 0.65 (95% CI, 0.36-1.16). Taken together, the results showed that in North Indian population, ERalpha and CYP19 genes may be playing a role in the risk of prostate cancer.
authors.affiliation: Department of Biotechnology, Panjab University, Chandigarh, India.
authors.forename: Khadijeh
authors.initials: K
authors.lastname: Onsory
authors.forename: R C
authors.initials: RC
authors.lastname: Sobti
authors.forename: Adnan Issa
authors.initials: AI
authors.lastname: Al-Badran
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Watanabe
authors.forename: Taizo
authors.initials: T
authors.lastname: Shiraishi
authors.forename: Awtar
authors.initials: A
authors.lastname: Krishan
authors.forename: Harsh
authors.initials: H
authors.lastname: Mohan
authors.forename: Pushpinder
authors.initials: P
authors.lastname: Kaur
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D001141:Aromatase / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007194:India; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D011944:Receptors, Androgen / Q000235:genetics; D018167:Receptors, Calcitriol / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D011960:Receptors, Estrogen / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics; D012307:Risk Factors
chemical_list: C410798:AR protein, human; D011944:Receptors, Androgen; D018167:Receptors, Calcitriol; D018160:Receptors, Cytoplasmic and Nuclear; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D001141:Aromatase