title: [Changes of insulin-like growth factor-I in focal cerebral ischemical reperfusion injury in rats].
abstract: OBJECTIVE
  To study the changes of insulin-like growth factor-I (IGF-I) in focal cerebral ischemical reperfusion injury model.
  
  
  METHODS
  Focal cerebral ischemia was induced in rats using filament method, and the expressions of IGF-I was detected with immunohistochemical staining.
  
  
  RESULTS
  The expression of IGF-I was very low in normal brain tissues, but increased in the infracted area and penumbra after cerebral ischemia. The expressions of IGF-I reached the peak level of 14.83-/+0.48 at days 3 after reperfusion.
  
  
  CONCLUSIONS
  Focal cerebral ischemia reperfusion injury enhances the expression of endogenous IGF-I.
authors.affiliation: Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. wuhymail@126.com
authors.forename: Hong-ying
authors.initials: HY
authors.lastname: Wu
authors.forename: Jiang-zhong
authors.initials: JZ
authors.lastname: Fan
authors.forename: Ren
authors.initials: R
authors.lastname: Luo
authors.forename: Chuan
authors.initials: C
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Wei
mesh_terms: D000818:Animals; D005260:Female; D007150:Immunohistochemistry; D020244:Infarction, Middle Cerebral Artery / Q000378:metabolism / Q000473:pathology; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000378:metabolism*
chemical_list: D007334:Insulin-Like Growth Factor I