title: Guadinomines, Type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. II: physico-chemical properties and structure elucidation.
abstract: The structures of guadinomines, new inhibitors of a bacterial Type III secretion system produced by Streptomyces sp. K01-0509, were elucidated by spectroscopic studies including various NMR experiments. Guadinomines A, B, C(1), C(2) and D consist of a carbamoylated cyclic guanidinyl moiety, an alkyl chain moiety and an L-Ala-L-Val moiety in common, while guadinomic acid is a smaller molecule consisting of a carbamoylated cyclic guanidinyl moiety and a hydroxyl hexanoate moiety.
authors.affiliation: The Kitasato Institute, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Iwatsuki
authors.forename: Ryuji
authors.initials: R
authors.lastname: Uchida
authors.forename: Hitomi
authors.initials: H
authors.lastname: Yoshijima
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ui
authors.forename: Kazuro
authors.initials: K
authors.lastname: Shiomi
authors.forename: Yong-Pil
authors.initials: YP
authors.lastname: Kim
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Hirose
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Sunazuka
authors.forename: Akio
authors.initials: A
authors.lastname: Abe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002208:Caproates / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D048289:Imidazolidines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D002208:Caproates; D004151:Dipeptides; D048289:Imidazolidines; C530707:guadinomic acid; C530702:guadinomine A; C530703:guadinomine B; C530704:guadinomine C; C530705:guadinomine D; C530706:guadinomine E