Multiple ADH genes are associated with upper aerodigestive cancers.
Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.
Hashibe
Mia
M
International Agency for Research on Cancer, Lyon, France.
McKay
James D
JD
Curado
Maria Paula
MP
Oliveira
Jose Carlos
JC
Koifman
Sergio
S
Koifman
Rosalina
R
Zaridze
David
D
Shangina
Oxana
O
Wünsch-Filho
Victor
V
Eluf-Neto
Jose
J
Levi
Jose Eduardo
JE
Matos
Elena
E
Lagiou
Pagona
P
Lagiou
Areti
A
Benhamou
Simone
S
Bouchardy
Christine
C
Szeszenia-Dabrowska
Neonilia
N
Menezes
Ana
A
Dall'Agnol
Marinel Mór
MM
Merletti
Franco
F
Richiardi
Lorenzo
L
Fernandez
Leticia
L
Lence
Juan
J
Talamini
Renato
R
Barzan
Luigi
L
Mates
Dana
D
Mates
Ioan Nicolae
IN
Kjaerheim
Kristina
K
Macfarlane
Gary J
GJ
Macfarlane
Tatiana V
TV
Simonato
Lorenzo
L
Canova
Cristina
C
Holcátová
Ivana
I
Agudo
Antonio
A
Castellsagué
Xavier
X
Lowry
Ray
R
Janout
Vladimir
V
Kollarova
Helena
H
Conway
David I
DI
McKinney
Patricia A
PA
Znaor
Ariana
A
Fabianova
Eleonora
E
Bencko
Vladimir
V
Lissowska
Jolanta
J
Chabrier
Amelie
A
Hung
Rayjean J
RJ
Gaborieau
Valerie
V
Boffetta
Paolo
P
Brennan
Paul
P
D000328:Adult; D017677:Age Distribution; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000428:Alcohol Drinking; D020751:Alcohol-Induced Disorders / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
C489332:ADH1B protein, human; C526911:ADH7 protein, human; D000426:Alcohol Dehydrogenase