Ariakemicins A and B, novel polyketide-peptide antibiotics from a marine gliding bacterium of the genus Rapidithrix.
Ariakemicins A (1) and B (2), unusual linear hybrid polyketide-nonribosomal peptide antibiotics, were discovered from the fermentation extract of the marine gliding bacterium Rapidithrix sp. These metabolites were positional isomers with regard to a double bond and chromatographically inseparable, rendering the structure study on a mixture basis. The ariakemicins were composed of threonine, two omega-amino-(omega-3)-methyl carboxylic acids with diene or triene units, and delta-isovanilloylbutyric acid. The antibiotics selectively inhibited the growth of Gram-positive bacteria.
Oku
Naoya
N
Applied Bioorganic Chemistry Group, Marine Biotechnology Institute Co Ltd, Kamaishi, Iwate, Japan. noku@riken.jp
Adachi
Kyoko
K
Matsuda
Satoru
S
Kasai
Hiroaki
H
Takatsuki
Akira
A
Shizuri
Yoshikazu
Y
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D041963:Bacteroidetes / Q000737:chemistry*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D009842:Oligopeptides; D011090:Polyenes; C530463:ariakemicin A; C530464:ariakemicin B