[Afobazole metabolism in rats].
Metabolism of afobazole in rats has been studied using mass-spectrometry and HPLC, which revealed 17 products of afobazole biotransformation along with the parent compound. The structures of six afobazole metabolites were established and confirmed by comparison of HPLC retention times with the synthetic reference compounds and HPLC/mass spectrometry. Other metabolites were characterized by the masses of molecular ions. A significant fraction of the drug dose is biotransformed with the formation of hydroxylated benzimidazole moiety and oxidated morpholine.
Seredenin
S B
SB
Viglinskaia
A O
AO
Mozhaeva
T Ia
TIa
Kolyvanov
G B
GB
Litvin
A A
AA
Avdiunina
N I
NI
Savel'ev
V L
VL
Zgerdev
V P
VP
D000818:Animals; D014151:Anti-Anxiety Agents / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001562:Benzimidazoles / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D008297:Male; D013058:Mass Spectrometry; D009025:Morpholines / Q000097:blood / Q000378:metabolism* / Q000652:urine; D051381:Rats
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines