title: Tolperisone: a typical representative of a class of centrally acting muscle relaxants with less sedative side effects.
abstract: Tolperisone, a piperidine derivative, is assigned to the group of centrally acting muscle relaxants and has been in clinical use now for decades. The review summarizes the known pharmacokinetics, pharmacodynamics, toxicology and side effects in humans and the clinical use of tolperisone. A future perspective for further exploration of this drug is given.
authors.affiliation: Department for Neurology, Medical University of Graz, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Quasthoff
authors.forename: Claudia
authors.initials: C
authors.lastname: Möckel
authors.forename: Walter
authors.initials: W
authors.lastname: Zieglgänsberger
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Schreibmayer
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central / Q000009:adverse effects / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D014049:Tolperisone / Q000009:adverse effects / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central; D014049:Tolperisone