title: Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review.
abstract: The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/index.html ). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The meta-analysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-ORm2/m2: 1.9, 95% confidence interval: 1.4-2.7; Pooled ORm2m2: 2.0, 95% confidence interval: 1.3-3.1; ORm1m2 or [infi]m2m2: 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (ORVal/Val: 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer.
authors.affiliation: Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Leonor
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authors.lastname: Foulkes
authors.forename: Eny Maria
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authors.lastname: Goloni-Bertollo
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authors.lastname: Hatagima
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authors.forename: Shunji
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authors.lastname: Morita
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authors.forename: Kwang-Kyun
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authors.forename: Erika Cristina
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authors.lastname: Pavarino Bertelli
authors.forename: Enilze Maria
authors.initials: EM
authors.lastname: de Souza Fonseca Ribeiro
authors.forename: Bidyut
authors.initials: B
authors.lastname: Roy
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Spitz
authors.forename: Richard C
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authors.lastname: Strange
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mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005091:Exons; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D009062:Mouth Neoplasms / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D010610:Pharyngeal Neoplasms / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D014029:Tobacco Use Disorder / Q000150:complications
chemical_list: D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase