title: A mild, one-pot synthesis of 4-quinolones via sequential Pd-catalyzed amidation and base-promoted cyclization.
abstract: A mild, one-pot synthesis of 4-quinolones is described. Under the optimal conditions, a variety of 2-substituted 4-quinolones were synthesized via sequential palladium-catalyzed amidation of 2'-bromoacetophenones followed by base-promoted intramolecular cyclization.
authors.affiliation: Chemical Process R&D, Amgen Inc, Thousand Oaks, CA 91320, USA. jhuang@amgen.com
authors.forename: Jinkun
authors.initials: J
authors.lastname: Huang
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Anthony O
authors.initials: AO
authors.lastname: King
authors.forename: Mina
authors.initials: M
authors.lastname: Dilmeghani
authors.forename: Robert D
authors.initials: RD
authors.lastname: Larsen
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Faul
mesh_terms: D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D015363:Quinolones; D010165:Palladium