title: [Expression of FHIT gene protein in laryngeal carcinoma].
abstract: OBJECTIVE
  To investigate the role and clinical significance of the expression of FHIT gene in development and progression of laryngeal squamous cell carcinoma(LSCC).
  
  
  METHODS
  The expression FHIT protein was detected by immunohistochemistry method in the 52 cases with LSCC and 23 cases of adjacent cancer tissues and 10 cases of laryngeal normal mucosa. The expression of FHIT was analyzed in LSCC with different clinicopathological parameters.
  
  
  RESULTS
  The expression of FHIT in normal tissues (90.0%) and adjacent tissues (78.3%) was obvious higher than that in LSCC (46.2%), which had statistical significant difference (P < 0.01). There was a positive correlation between FHIT expression and TNM staging, lymph node metastasis; but not pathological grade.
  
  
  CONCLUSIONS
  The loss of FHIT expression may be correlated with the development and progression of laryngeal carcinoma. FHIT may be an important tumor suppressor gene in LSCC.
authors.affiliation: Department of Otolaryngology, Puren Hospital, Beijing, 100062, China. clt1974@sohu.com
authors.forename: Litang
authors.initials: L
authors.lastname: Cao
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Chen
authors.forename: Binquan
authors.initials: B
authors.lastname: Wang
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000378:metabolism*; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase