Functionalized thermoresponsive micelles self-assembled from biotin-PEG-b-P(NIPAAm-co-HMAAm)-b-PMMA for tumor cell target.
Novel micelles, comprising hydrophilic PEG shells, hydrophobic PMMA cores, and thermosensitive P(NIPAAm-co-HMAAm) segments were self-assembled from the biotin-PEG-b-P(NIPAAm-co-HMAAm)-b-PMMA triblock copolymer. The thermosensitive micelles exhibited superior stability and showed thermotriggered drug release behavior upon temperature alterations. The fluorescence spectroscopy and confocal microscopy studies confirmed that the self-assembled biotinylated micelles can be specifically and efficiently bonded to cancer cells with the administration of biotin-transferrin, suggesting that the multifunctional micelles have great potential as drug carriers for tumor targeting chemotherapy.
Cheng
Cheng
C
Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University,Wuhan 430072, China.
Wei
Hua
H
Zhu
Jing-Ling
JL
Chang
Cong
C
Cheng
Han
H
Li
Cao
C
Cheng
Si-Xue
SX
Zhang
Xian-Zheng
XZ
Zhuo
Ren-Xi
RX
D000178:Acrylamides / Q000737:chemistry*; D001360:Avidin / Q000737:chemistry / Q000378:metabolism; D001710:Biotin / Q000737:chemistry*; D019921:Biotinylation; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D008823:Micelles; D018613:Microscopy, Confocal; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D013696:Temperature
D000178:Acrylamides; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008024:Ligands; D008823:Micelles; D001360:Avidin; D001710:Biotin; D019904:Polymethyl Methacrylate