Silacyclic derivatives of heteroaromatic sulfides as selective cholesterol level lowering and vasodilating agents.
Silacyclic derivatives of heteroaromatic sulfides have been prepared by using phase transfer catalytic (PTC) system thiol / silacyclopropyl iodide / solid K(2)CO(3) / 18-crown-6 / toluene. The target sulfides were isolated in yields up to 70 %. The S-derivatives of N-methylimidazolyl, benzoxazolyl and 1,3,4-triazolyl thiols selectively lowered the low density lipoprotein (LDL) level in mice with the high cholesterol diet in nutrition.
Abele
Edgars
E
Latvian Institute of Organic Synthesis 21 Aizkraukles street Riga LV-1006 Latvia.
Rubina
Kira
K
Abele
Ramona
R
Dzenitis
Olegs
O
Arsenyan
Pavel
P
Popelis
Juris
J
Veveris
Maris
M
Meirena
Dainuvite
D
Lukevics
Edmunds
E