title: Sequential magnetic resonance imaging changes after suspected global brain ischaemia in a dog.
abstract: Sequential magnetic resonance imaging studies over a period of 18 months were performed in a two-year-old pug dog after suspected global brain ischaemia following an anaesthetic accident. The dog was presented with seizures and neurological deficits consistent with a left brainstem and multifocal/diffuse forebrain lesion after an asymptomatic interval of 72 hours following the ischaemic event. Magnetic resonance imaging scans were performed three hours, six weeks, seven and 18 months after the incident. In the acute stage, signal hyperintensity was evident in the occipital and parietal regions of the cerebral cortex and in both rostral caudate nuclei. Slight involvement of the white matter was also noticed. In the chronic phase, the signal hyperintensity in the affected areas of the cortex was diminished and smaller in size, whereas the white matter did not appear to be compromised anymore.
authors.affiliation: Department of Small Animal Medicine, University of Leipzig, An den Tierkliniken 23, 04103 Leipzig, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Timm
authors.forename: T
authors.initials: T
authors.lastname: Flegel
authors.forename: G
authors.initials: G
authors.lastname: Oechtering
mesh_terms: D000758:Anesthesia / Q000009:adverse effects / Q000662:veterinary; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000927:Anticonvulsants / Q000008:administration & dosage; D001049:Apnea / Q000139:chemically induced / Q000662:veterinary; D001919:Bradycardia / Q000139:chemically induced / Q000662:veterinary; D001921:Brain / Q000473:pathology*; D002545:Brain Ischemia / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D003975:Diazepam / Q000008:administration & dosage; D004283:Dog Diseases / Q000175:diagnosis* / Q000209:etiology; D004285:Dogs; D004359:Drug Therapy, Combination; D008279:Magnetic Resonance Imaging / Q000662:veterinary*; D008297:Male; D009460:Neurologic Examination / Q000662:veterinary; D011239:Prednisolone / Q000008:administration & dosage; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary; D013557:Switzerland; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D011239:Prednisolone; D003975:Diazepam