title: Control of mRNA degradation in trypanosomes.
abstract: Control of gene expression in trypanosomes relies almost exclusively on post-transcriptional mechanisms. Trypanosomes have the normal enzymes for mRNA decay: both the exosome and a 5'-3'-exoribonuclease are important in the degradation of very unstable transcripts, whereas the CAF1/NOT complex plays a major role in the degradation of all mRNAs tested. Targeted RNA interference screening was used to identify RNA-binding proteins that regulate mRNA degradation, and it revealed roles for proteins with RNA recognition motifs or pumilio domains.
authors.affiliation: ZMBH (Zentrum für Molekulare Biologie der Universität Heidelberg), Im Neuenheimer Feld 282, D69120 Heidelberg, Germany. cclayton@zmbh.uni-heidelberg.de
authors.forename: Christine
authors.initials: C
authors.lastname: Clayton
authors.forename: Angela
authors.initials: A
authors.lastname: Schwede
authors.forename: Mhairi
authors.initials: M
authors.lastname: Stewart
authors.forename: Ana
authors.initials: A
authors.lastname: Robles
authors.forename: Corinna
authors.initials: C
authors.lastname: Benz
authors.forename: June
authors.initials: J
authors.lastname: Po
authors.forename: Martin
authors.initials: M
authors.lastname: Wurst
authors.forename: Rafael
authors.initials: R
authors.lastname: Queiroz
authors.forename: Rafael
authors.initials: R
authors.lastname: Quieroz
authors.forename: Stuart
authors.initials: S
authors.lastname: Archer
mesh_terms: D000818:Animals; D007700:Kinetics; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D016601:RNA-Binding Proteins / Q000378:metabolism; D014345:Trypanosoma / Q000201:enzymology / Q000378:metabolism*
chemical_list: D016601:RNA-Binding Proteins