title: Serum inflammatory adhesion molecules and high-sensitivity C-reactive protein correlates with delayed ischemic neurologic deficits after subarachnoid hemorrhage.
abstract: BACKGROUND
  The purpose of the present study was to investigate the relationship between serum concentrations of the immunoglobulin-like superfamily, selectins, hsCRP, and the development of DIND in patients with aneurysmal SAH.
  
  
  METHODS
  Serum ICAM-1, VCAM-1, E-selectin, P-selectin, L-selectin, and hsCRP were measured in 33 patients with SAH who underwent aneurysmal clipping within 48 hours of the onset of symptoms. Serum samples were obtained during the early period (day 0) and the late period (day 7).
  
  
  RESULTS
  The serum concentrations of ICAM-1 (P = .009), VCAM-1 (P = .0383) and hsCRP (P = .0014) during the early period were significantly higher in patients with SAH than in control patients. Further, serum hsCRP concentration during the late period was significantly higher in patients with SAH than in control patients (P = 0033). Finally, serum concentrations of ICAM-1, VCAM-1, and hsCRP during the early (P = .0055, P = .0266, and P = .0266) and late (P = .0423, P = .0041, and P = .0004) period were significantly higher in patients with DIND than in patients without DIND.
  
  
  CONCLUSIONS
  Serum levels of ICAM-1, VCAM-1 and hsCRP during the early and late period following SAH correlate with DIND.
authors.affiliation: Department of Neurosurgery, Iwate Medical University, Morioka 020-8505, Japan. yokubo@iwate-med.ac.jp
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kubo
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Ogasawara
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kakino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kashimura
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Tomitsuka
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sugawara
authors.forename: Akira
authors.initials: A
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D017542:Aneurysm, Ruptured / Q000097:blood / Q000150:complications / Q000601:surgery; D002545:Brain Ischemia / Q000097:blood / Q000209:etiology*; D002097:C-Reactive Protein / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000097:blood / Q000150:complications / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D019087:Selectins / Q000097:blood*; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000150:complications* / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015815:Cell Adhesion Molecules; D019087:Selectins; D002097:C-Reactive Protein