title: Strong association between nutritional markers and arterial stiffness in continuous ambulatory peritoneal dialysis patients.
abstract: BACKGROUND
  Malnutrition is a predictor of cardiovascular disease in dialysis patients, but the mechanisms remain unknown. We investigated links between nutritional markers and arterial stiffness in continuous ambulatory peritoneal dialysis patients.
  
  
  METHODS
  We evaluated the relationship between arterial stiffness evaluated by pulse-wave velocity (PWV) and four estimates of nutritional status (serum albumin, handgrip strength [HGS], subjective global assessment [SGA], and bioelectrical impedance analysis phase angle [PA]) in 124 PD patients.
  
  
  RESULTS
  Malnourished patients exhibited a significantly higher PWV than those classified as well-nourished by SGA (p < 0.05). Furthermore, PWV correlated negatively with albumin, HGS and PA (p < 0.001, respectively). PWV was also correlated with age, systolic blood pressure, and C-reactive protein. In multivariate regression analysis, albumin, HGS, SGA and PA were each independently associated with PWV after adjustment.
  
  
  CONCLUSIONS
  The significant association between each nutritional marker and PWV in PD patients was independent of inflammation and diabetic state, suggesting that malnutrition may contribute to vascular dysfunction.
authors.affiliation: Division of Nephrology, Peking University Third Hospital, Beijing, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Gu
authors.forename: Li-Tao
authors.initials: LT
authors.lastname: Cheng
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Chen
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Sun
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Tang
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Guo
authors.forename: Jonas
authors.initials: J
authors.lastname: Axelsson
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D007249:Inflammation; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D044342:Malnutrition / Q000150:complications*; D008875:Middle Aged; D015999:Multivariate Analysis; D009752:Nutritional Status; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011673:Pulsatile Flow; D014655:Vascular Resistance
chemical_list: D015415:Biomarkers