Interleukin-2 immediate type hypersensitivity?
Two patients with metastatic malignant melanoma developed immediate type hypersensitivity-like symptoms while being treated with recombinant interleukin-(IL-)2 immunotherapy. Both patients showed positive skin prick tests to IL-2, enhanced basophil degranulation in vitro and responded to anti-histamines, but laboratory investigations suggested an IgE-independent, pseudoallergic mast cell degranulation against IL-2.
Caucig
Peri
P
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany.
Lescau
Susanne
S
Knop
Jürgen
J
Maurer
Marcus
M
von Stebut
Esther
E
D000328:Adult; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D007376:Interleukin-2