title: Ultrasmall c(RGDyK)-coated Fe3O4 nanoparticles and their specific targeting to integrin alpha(v)beta3-rich tumor cells.
abstract: We report a direct synthesis of ultrasmall c(RGDyK) peptide-coated Fe3O4 NPs (<10 nm in hydrodynamic diameter) and demonstrate their in vivo tumor-specific targeting capability. The Fe3O4 NPs are synthesized by thermal decomposition of iron pentacarbonyl in the presence of 4-methylcatechol (4-MC), and the peptide is coupled to the nanoparticles through 4-MC via Mannich reaction. The c(RGDyK)-MC-Fe3O4 NPs have an overall diameter of approximately 8.4 nm and are stable in physiological conditions. When administrated intravenously, these c(RGDyK)-MC-Fe3O4 NPs accumulate preferentially in the integrin alphavbeta3-rich tumor area, which are readily tracked by MRI.
authors.affiliation: Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Xie
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.forename: Ha-Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Chenjie
authors.initials: C
authors.lastname: Xu
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Hsu
authors.forename: Sheng
authors.initials: S
authors.lastname: Peng
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
authors.forename: Shouheng
authors.initials: S
authors.lastname: Sun
mesh_terms: D000818:Animals; D002396:Catechols / Q000737:chemistry; D045744:Cell Line, Tumor; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000378:metabolism; D058085:Iron Compounds / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D051379:Mice; D008815:Mice, Inbred Strains; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D010456:Peptides, Cyclic / Q000737:chemistry*
chemical_list: D002396:Catechols; D005290:Ferric Compounds; D039302:Integrin alphaVbeta3; D058085:Iron Compounds; D010456:Peptides, Cyclic; C018599:4-methylcatechol; C000499:ferric oxide; C515100:iron pentacarbonyl