A role for Numb in p53 stabilization.
The cell-fate determinant Numb has recently been shown to help activate the tumor suppressor protein p53. Loss of Numb in breast cancers would result, therefore, in both the activation of the potential oncogene Notch and the diminution of tumor suppression by p53.
Carter
Stephanie
S
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, UK.
Vousden
Karen H
KH
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism; D006801:Humans; D007605:Juvenile Hormones / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D029721:Drosophila Proteins; D007605:Juvenile Hormones; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C113026:NUMB protein, human; D016159:Tumor Suppressor Protein p53; C060606:numb protein, Drosophila