Cytotoxic staurosporines from the marine ascidian Cystodytes solitus.
Two new indolocarbazole alkaloids, 7-oxo-3,8,9-trihydroxystaurosporine (1) and 7-oxo-8,9-dihydroxy-4'-N-demethylstaurosporine (2), were isolated from samples of the marine ascidian Cystodytes solitus. Their structures were determined by a combination of spectroscopic techniques, including (+)-HRMALDITOFMS and 1D and 2D NMR spectroscopy, and comparison with published data for related structures. Both compounds displayed strong cytotoxicity against three human tumor cell lines.
Reyes
Fernando
F
Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770-Colmenar Viejo, Madrid, Spain. jfreyes2@pharmamar.com.
Fernández
Rogelio
R
Rodríguez
Alfredo
A
Bueno
Santiago
S
de Eguilior
Carlos
C
Francesch
Andrés
A
Cuevas
Carmen
C
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D019311:Staurosporine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013636:Tanzania; D014561:Urochordata / Q000737:chemistry*
C531260:7-oxo-3,8,9-trihydroxystaurosporine; C531261:7-oxo-8,9-dihydroxy-4'-N-demethylstaurosporine; D000470:Alkaloids; D000970:Antineoplastic Agents; D019311:Staurosporine