A useful Pd-catalyzed Negishi coupling approach to benzylic sulfonamide derivatives.
A mild catalytic system to access diversely functionalized benzylic sulfonamides has been developed. Palladium-catalyzed alpha-arylation by Negishi cross-coupling of sulfonamide-stabilized anions and a wide range of aryl iodides, bromides, and triflates constitutes a practical strategy for the synthesis of various benzylic sulfonamides.
Zhou
Gang
G
Department of Medicinal Chemistry, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA. gang.zhou@spcorp.com
Ting
Pauline
P
Aslanian
Robert
R
Piwinski
John J
JJ
D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
D001555:Benzene Derivatives; D013449:Sulfonamides; D010165:Palladium