title: C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I.
abstract: Some dumbbell-shaped circular oligonucleotides containing internal C3-spacers and Topo I-binding sites were designed and synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as resisted the degradation by some DNA repair enzymes.
authors.affiliation: Department of Chemistry, 3 Science Drive 3, National University of Singapore, Singapore 117543, Singapore.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Wang
authors.forename: Magdeline Tao Tao
authors.initials: MT
authors.lastname: Ng
authors.forename: Tianyan
authors.initials: T
authors.lastname: Zhou
authors.forename: Xinming
authors.initials: X
authors.lastname: Li
authors.forename: Choon Hong
authors.initials: CH
authors.lastname: Tan
authors.forename: Tianhu
authors.initials: T
authors.lastname: Li
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors
chemical_list: D004791:Enzyme Inhibitors; D009841:Oligonucleotides; D059004:Topoisomerase I Inhibitors