title: Successful radiofrequency catheter ablation for electrical storm of ventricular fibrillation in a patient with Brugada syndrome.
abstract: The case of a 41-year-old man with Brugada syndrome (BS) who suffered electrical storms (ES) of ventricular fibrillation (VF) is presented. Although intravenous infusion of isoproterenol (ISP) suppressed the VF occurrence, he consistently experienced recurrence of VF following discontinuation of ISP infusion. Quinidine and cilostazol were ineffective. An analysis of VF episodes on electrocardiogram monitoring revealed that the QRS morphology of the first beat of all VF episodes was identical to that of premature ventricular complexes (PVCs) with a left bundle branch-block morphology and inferior axis, which occurred repetitively before the episodes of VF and were recorded throughout the day. In addition, stored electrograms from the implantable cardioverter defibrillator showed that the first beat of all VF episodes had the same morphology. On electrophysiological study, the VF-triggering PVC was found to originate from the posterior portion of the right ventricular outflow tract area and their elimination, which was achieved with radiofrequency catheter ablation (RFCA), resulted in the suppression of ES. Although several other PVCs were still observed, the patient has been free of VF during the 29-month follow-up period. This case indicates that RFCA of VF-triggering PVCs may be useful in the treatment of drug-resistant ES in patients with BS.
authors.affiliation: Department of Internal Medicine and Cardiology, Osaka City University Medical School, Osaka, Japan.
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Nakagawa
authors.forename: Masahiko
authors.initials: M
authors.lastname: Takagi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tatsumi
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshiyama
mesh_terms: D000328:Adult; D053840:Brugada Syndrome / Q000150:complications* / Q000601:surgery*; D017115:Catheter Ablation; D004351:Drug Resistance; D006801:Humans; D008297:Male; D055502:Secondary Prevention; D013438:Sulfhydryl Compounds; D014693:Ventricular Fibrillation / Q000209:etiology* / Q000601:surgery*; D018879:Ventricular Premature Complexes / Q000209:etiology / Q000601:surgery
chemical_list: D013438:Sulfhydryl Compounds; C101969:EC 27