title: The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in preterm newborns.
abstract: OBJECTIVE
  To investigate the effect of dietary supplementation with a probiotic on feeding tolerance and gastrointestinal motility in healthy formula-fed preterm infants.
  
  
  METHODS
  Thirty preterm newborns were enrolled; 10 were exclusively breast-fed, and the remaining 20 were randomly assigned in a double-blind manner to receive either Lactobacillus reuteri ATCC 55730 (at dose of 1 x 10(8) colony forming units a day) or placebo for 30 days. Clinical symptoms of gastrointestinal function (regurgitation, vomiting, inconsolable crying, and evacuation) and physiological variables (gastric electrical activity and emptying) were recorded before and after the dietary intervention.
  
  
  RESULTS
  Body weight gains per day were similar for the 3 groups, and no adverse events were recorded. Newborns receiving probiotics showed a significant decrease in regurgitation and mean daily crying time and a larger number of stools compared with those given placebo. Gastric emptying rate was significantly increased, and fasting antral area was significantly reduced in both the newborns receiving L. reuteri and breast-fed newborns compared with placebo.
  
  
  CONCLUSIONS
  Our results suggest a useful role for L. reuteri supplementation in improving feeding tolerance and gut function in formula-fed preterm newborns.
authors.affiliation: Department of Pediatrics, University of Bari Policlinico, Bari, Italy. f.indrio@neonatologia.uniba.it
authors.forename: Flavia
authors.initials: F
authors.lastname: Indrio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Riezzo
authors.forename: Francesco
authors.initials: F
authors.lastname: Raimondi
authors.forename: Massimo
authors.initials: M
authors.lastname: Bisceglia
authors.forename: Luciano
authors.initials: L
authors.lastname: Cavallo
authors.forename: Ruggiero
authors.initials: R
authors.lastname: Francavilla
mesh_terms: D003672:Defecation; D004311:Double-Blind Method; D004435:Eating; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D052200:Limosilactobacillus reuteri; D008297:Male; D019936:Probiotics / Q000627:therapeutic use*