Scintigraphic imaging of paediatric thyroid dysfunction.
Imaging of thyroid dysfunction is safe and clinically relevant in children. In congenital hypothyroidism (CH), thyroid imaging permits a precise characterization of the aetiology, which is important for genetic counselling and clinical management. CH may be due to thyroid dysgenesis (ectopia, hypoplasia and athyrosis) or occurs in eutopic glands. In the latter, hypothyroidism may be either transient, especially after iodine overload, or due to permanent autosomal recessive dyshormonogenesis. Thyroid scintigraphy (TS) with either 99mTcO4 or 123I will identify ectopic thyroid tissue, which is the commonest cause of CH. However, recent reports favour the use of 123I, which enhances the accuracy of the aetiological classification. In cases of eutopic thyroid, the measurement of 123I uptake before and after perchlorate administration evaluates the organification process. At all ages, colour Doppler ultrasound scanning (CDU) is helpful in assessing thyroid volume, in identifying nodules and in characterizing tissue vascularization. TS and CDU images of most paediatric thyroid dysfunctions are presented.
Clerc
J
J
Department of Nuclear Medicine, Hôpital Cochin, Paris, France. jerome.clerc@cch.aphp.fr
Monpeyssen
H
H
Chevalier
A
A
Amegassi
F
F
Rodrigue
D
D
Leger
F A
FA
Richard
B
B
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003409:Congenital Hypothyroidism / Q000000981:diagnostic imaging*; D018618:Echocardiography, Doppler, Color / Q000379:methods; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011877:Radionuclide Imaging / Q000379:methods*; D013961:Thyroid Gland / Q000000981:diagnostic imaging*