Long-term results of Artecoll injection laryngoplasty for patients with unilateral vocal fold motion impairment: safety and clinical efficacy.
OBJECTIVE
To determine the long-term clinical efficacy and safety of injections of Artecoll, a soft-tissue filler consisting of a suspension of polymethyl methacrylate microspheres in a 3.5% solution of bovine collagen, into a vocal fold for managing glottal insufficiency secondary to unilateral vocal fold motion impairment.


METHODS
Single-institution retrospective study.


METHODS
A single tertiary care teaching hospital of Sungkyunkwan University School of Medicine.


METHODS
Ninety-six patients with unilateral vocal fold motion impairment.


METHODS
Percutaneous Artecoll injection laryngoplasty under local anesthesia.


METHODS
Acoustic, aerodynamic, and stroboscopic analyses were performed before injection and 1 week and 3, 6, and 12 months after injection. Two speech-language pathologists performed the perceptual assessment, and we used the subjective rating of hoarseness by the patients.


RESULTS
The maximal phonation time, shimmer (amplitude variation), jitter (frequency variation), and ratio of noise to harmonic showed significant improvement 3 months after injection; these improvements were maintained 12 months after injection (P < .05). The GRBAS scale (overall grade of hoarseness, roughness, breathiness, asthenicity, and strain) grades and subjective patient-rated scores of hoarseness improved from 1 week after injection, and the improvements were maintained 12 months after injection (P < .05). We observed no significant early or delayed adverse events.


CONCLUSIONS
Injection laryngoplasty with Artecoll is a safe, useful, and durable treatment option for the management of glottal insufficiency secondary to unilateral vocal fold motion impairment.
Min
Jin-Young
JY
Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Gangnam-Gu, Seoul, Korea.
Hong
Sang-Duk
SD
Kim
Kwhanmien
K
Son
Young-Ik
YI
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003094:Collagen / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D019904:Polymethyl Methacrylate / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D019736:Prostheses and Implants; D012189:Retrospective Studies; D012449:Safety; D016896:Treatment Outcome; D014826:Vocal Cord Paralysis / Q000628:therapy*; D014832:Voice Disorders / Q000628:therapy*; D014833:Voice Quality
C445359:Artecoll; D003094:Collagen; D019904:Polymethyl Methacrylate