New cytotoxic diarylheptanoids from the rhizomes of Alpinia officinarum.
Bioassay-guided fractionation of the cytotoxic MeOH extract from the rhizomes of Alpinia officinarum Hance led to the isolation of two new diarylheptanoids named alpinoid D (1) and E (2), together with fifteen known diarylheptanoids (3 - 17). The structures of compounds 1 and 2 were elucidated on the basis of spectroscopic data and chemical evidence. The cytotoxic activity of the isolated diarylheptanoids was evaluated against the IMR-32 human neuroblastoma cell line. Among the tested compounds, 11, 12 and 14 exhibited the most potent activities with IC (50) values of 0.83, 0.23 and 0.11 microM, respectively.
Sun
Yi
Y
College of Pharmacy, Nihon University, Chiba, Japan.
Tabata
Keiichi
K
Matsubara
Hideki
H
Kitanaka
Susumu
S
Suzuki
Takashi
T
Yasukawa
Ken
K
D032429:Alpinia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D036381:Diarylheptanoids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009447:Neuroblastoma / Q000188:drug therapy; D027343:Rhizome / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D036381:Diarylheptanoids