Effects of mannooligosaccharides from coffee mannan on blood pressure in Dahl salt-sensitive rats.
Dahl salt-sensitive (Dahl-S) rats, serving as a model of hereditary hypertension, were used to examine the effect of mannooligosaccharides (MOS) on blood pressure. Dahl-S rats were induced to develop hypertension by administering them with a 1.25% salt solution ad libitum. In a 10-wk experimental period, the Dahl-S control and MOS groups developed and maintained significantly higher blood pressure than the Dahl salt-resistant normal control group. The MOS group showed a significantly lower blood pressure than the Dahl-S control group after 5-wk of treatment (p<0.05). In addition, the serum aldosterone level of the MOS group significantly decreased (p<0.05). The findings of this study using a model of hypertensive rats suggest that MOS are able to suppress an elevation in blood pressure.
Hoshino-Takao
Izumi
I
R & D and Engineering Deptartment, Ajinomoto General Foods Inc, Tokyo, Japan.
Fujii
Shigeyoshi
S
Ishii
Asako
A
Han
Li-Kun
LK
Okuda
Hiromichi
H
Kumao
Toshio
T
D000450:Aldosterone / Q000097:blood; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003069:Coffee / Q000737:chemistry*; D004032:Diet / Q000379:methods; D004195:Disease Models, Animal; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D008297:Male; D008351:Mannans / Q000008:administration & dosage / Q000494:pharmacology*; D009844:Oligosaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D020303:Rats, Inbred Dahl; D012965:Sodium Chloride / Q000008:administration & dosage; D013997:Time Factors
D003069:Coffee; D008351:Mannans; D009844:Oligosaccharides; D012965:Sodium Chloride; D000450:Aldosterone