title: Radioprotectant Activity of 5-Diethylsulfonamoylsalicylatocopper(II) in Gamma Irradiated Mice.
abstract: Survival and changes in mean body mass of whole-body irradiated mice were determined to examine the radioprotectant activity of 5-diethylsulfonamoylsalicylatocopper(II) [Cu(II) (5-DESS)]. One of four groups of 25 female C57BL/6 mice were treated subcutaneously (sc)with 0, 10, 20, 40, 60, 80, 100, or 120 mumol Cu(II)(5- DESS)/kg of body mass 3 hours before exposure to 8.0 Gy, gamma irradiation. In this paradigm, doses of Cu(II)(5- DESS) increased survival up to 92% above vehicle-treated control mice (P = 0.008). Mean body mass determinations revealed that mice treated with 80 to 120 mumol Cu(II)(5-DESS)/kg of body mass exhibited a smaller decrease in body mass than other complex-treated groups. These results support the hypothesis that Cu(II)(5-DESS) is an effective radioprotectant.
authors.affiliation: Research Center University of Arkansas at Pine Bluff Pine Bluff Arkansas 71601 USA.
authors.forename: J A
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authors.lastname: Kuykendall Iii
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authors.lastname: Irving
authors.forename: M A
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authors.lastname: Wear
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authors.lastname: Sorenson
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authors.lastname: Maddox
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authors.initials: EL
authors.lastname: Williams
authors.forename: V A
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authors.lastname: Pham-Tran
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authors.lastname: Credit
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authors.lastname: Chowdhury
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authors.lastname: Khan
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authors.initials: JB
authors.lastname: Tipton
authors.forename: W M
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authors.lastname: Willingham
authors.forename: J R
authors.initials: JR
authors.lastname: Sorenson