title: Synthesis, characterization and antitumour activity of metal complexes of 5-carboxy-2-thiouracil.
abstract: Metal complexes of 5-carboxy-2-thiouracil with Mn(ll), Co(ll), Ni(ll), Cu(ll), Zn(ll) and Cd(ll) ions were synthesized, characterized, and subjected to a screening system for evaluation of antitumour activity against Sarcoma-180 (S-180) tumour cells. The complexes were characterized by elemental analysis, infrared, electronic spectra, room temperature magnetic measurements and powder X-ray diffraction. The antitumour activity results indicate that some complexes have antitumour activity both in vivo and in vitro against S-180 tumour cells.
authors.affiliation: Department of Chemistry University of Roorkee Roorkee 247 667 India.
authors.forename: U P
authors.initials: UP
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.forename: S M
authors.initials: SM
authors.lastname: Singh