title: Nutrition, anthropometry, gastrointestinal dysfunction, and circulating levels of tumour necrosis factor alpha receptor I and interleukin-1 receptor antagonist in children during stem cell transplantation.
abstract: To evaluate anthropometry, nutrition and gastrointestinal dysfunction, and to characterize the relation between these parameters and the inflammatory activity evaluated by plasma levels of soluble tumour necrosis factor alpha receptor I (sTNFRI) and interleukin-1 receptor antagonist (IL-1Ra) levels during stem cell transplantation (SCT) in children. Clinical assessments and blood sampling were performed on days -3, 0, +7, +15 and +31 in eight children undergoing SCT. Energy intake, anthropometry, gastrointestinal dysfunction (WHO toxicity score) and sTNFRI and IL-1Ra were evaluated. The energy intake was below recommended levels. There was a loss of lean body mass (arm muscle area)(median, 2031 mm(2) (day -3) vs 1477 mm(2) (day 31); p = 0.04), and of fat mass (arm fat area) (791 mm(2) (day -3) vs 648 mm(2) (day +31); p = 0.04). sTNFRI was elevated throughout the course of transplantation, and peaked after the day of graft infusion (day 0). sTNFRI levels at day 0 predicted changes in weight SDS (r = 0.65; p = 0.05), triceps skinfold SDS (r = 0.85; p = 0.007) and gastrointestinal dysfunction (r = 0.88; p = 0.004). Likewise, IL-1Ra levels at day 0 correlated with the gastrointestinal dysfunction (r = 0.83; p = 0.01) and with the change in weight SDS (r = 0.77; p = 0.03). This study suggests that pretransplant levels of inflammatory markers are associated with posttransplant symptoms of gastrointestinal dysfunction and loss of both fat and lean body mass. Future studies should address if the use of conditioning regimens with limited proinflammatory cytokine inducing activity, anti-inflammatory agents, or more optimised nutritional support can reduce the burden of such posttransplant complications.
authors.affiliation: Paediatric Clinics, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark. bua@dadlnet.dk
authors.forename: B U
authors.initials: BU
authors.lastname: Andreassen
authors.forename: A
authors.initials: A
authors.lastname: Paerregaard
authors.forename: K F
authors.initials: KF
authors.lastname: Michaelsen
authors.forename: J
authors.initials: J
authors.lastname: Andersen
authors.forename: C J
authors.initials: CJ
authors.lastname: Heilmann
authors.forename: K
authors.initials: K
authors.lastname: Müller
mesh_terms: D000293:Adolescent; D000886:Anthropometry / Q000379:methods; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005767:Gastrointestinal Diseases / Q000097:blood / Q000628:therapy*; D006801:Humans; D007223:Infant; D007249:Inflammation; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood / Q000378:metabolism*; D008297:Male; D052756:Nutritional Sciences; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood / Q000378:metabolism*; D033581:Stem Cell Transplantation / Q000379:methods*; D013997:Time Factors
chemical_list: D016207:Cytokines; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D047888:Receptors, Tumor Necrosis Factor, Type I