title: Novel isocyanide-based four-component reaction: a facile synthesis of fully substituted 3,4-dihydrocoumarin derivatives.
abstract: A novel isocyanide-based four-component reaction between a 2-hydroxybenzaldehyde, Meldrum's acid, an isocyanide, and an aromatic or an aliphatic alcohol efficiently provide 3,4-dihydrocoumarin derivatives in good to excellent yields without using any catalyst or activation. The reaction can be carried out as a simple one-pot protocol at room temperature.
authors.affiliation: Department of Chemistry, Shahid Beheshti University, Tehran, Iran. a-shaabani@cc.sbu.ac.ir
authors.forename: Ahmad
authors.initials: A
authors.lastname: Shaabani
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Soleimani
authors.forename: Ali Hossein
authors.initials: AH
authors.lastname: Rezayan
authors.forename: Afshin
authors.initials: A
authors.lastname: Sarvary
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Khavasi
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D003374:Coumarins; D003486:Cyanides; C013243:salicylaldehyde; C026308:3,4-dihydrocoumarin