[Like anticataract agents, the antiaggregants of lens crystallin. Communication 2. Study of the impact of chaperon-like (protective) activity of short-chain peptides on the rate of UV-induced aggregation of betaL-crystallins by eximer laser].
UV-induced aggregation of betaL-crystallin, one of the major lens proteins, was studied under its pulse radiation with XeCl laser at a wavelength of 308 nm. Unlike the in vitro tested dipeptides L-carnosine, N-acetyl carnosine, D-panthetine, and particularly their combination, the so-called new chaperon was demonstrated to slow down the rate of photoaggregatin of beta-crystallin. The new chaperon, a mixture of D-pathethine and N-acetyl carnosine was ascertained to protect a mixture of betaL- and alpha-crystallins from UV-induced aggregation to a greater extent than D-pathethine or N-acetyl carnosine used alone. An effective drug based on the new chaperon may be designed for the prevention of cataract in sight.
Soustov
L V
LV
Chelnokov
E V
EV
Sapogova
N V
NV
Bitiurin
N M
NM
Nemov
V V
VV
Karpova
O E
OE
Sheremet
N L
NL
Polunin
G S
GS
Avetisov
S E
SE
Ostrovskiĭ
M A
MA
D002336:Carnosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002386:Cataract / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004359:Drug Therapy, Combination; D006801:Humans; D054018:Lasers, Excimer / Q000009:adverse effects*; D007908:Lens, Crystalline / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D018832:Molecular Chaperones / Q000627:therapeutic use*; D014466:Ultraviolet Rays / Q000009:adverse effects*; D038204:beta-Crystallins / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects
D018832:Molecular Chaperones; D038204:beta-Crystallins; C033681:N-acetylcarnosine; D002336:Carnosine