[Determination of uric acid in the expressed prostatic secretion of chronic prostatitis patients and its clinical significance].
OBJECTIVE
To determine the level of uric acid (UA) in the expressed prostatic secretion (EPS) of chronic prostatitis patients and explore its clinical significance.


METHODS
A total of 91 patients with chronic prostatitis diagnosed by NIH standard were divided into a III A (n = 48) and a III B (n = 43) group, and healthy volunteers were selected as the control. The scores on the NIH-Chronic Prostatitis Symptom Index (CPSI) and the WBC count, pH value and UA level in EPS were evaluated for all the three groups.


RESULTS
The EPS UA concentration was (257.02 +/- 144.84) micromol/L in Group III B, significantly higher than in Group III A, (159. 73 +/- 121.49) micromol/L, (P < 0.01), and the control, (78.55 +/- 44.53) micromol/L, (P < 0.01). The level of EPS UA was correlated negatively with pH value (r = -0.398, P = 0.000), but positively with CPSI-P, CPSI-U and CPSI-T (r = 0.436, 0.316 and 0.403, P < 0.01).


CONCLUSIONS
Backflow of urine into prostatic ducts might cause chemical inflammation reaction by increasing UA concentration. There is a close relationship between the UA level in EPS and chronic prostatitis symptoms. Determination of the UA level in EPS is of great significance for the diagnosis and treatment of chronic prostatitis.
Hou
Bao-Shan
BS
PLA Research Institute of Clinical Laboratory Medicine, School of Clinical Medicine, Nanjing University Medicial College, Nanjing General Hospital of Nanjing Military Command, PlA , Nanjing, Jiangsu 210002, China.
Xia
Xin-Yi
XY
Pan
Lian-Jun
LJ
Yang
Bin
B
Shao
Yong
Y
Shang
Xue-Jun
XJ
Yao
Bing
B
Cui
Ying-Xia
YX
Huang
Yu-Feng
YF
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism* / Q000473:pathology; D011472:Prostatitis / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D014527:Uric Acid / Q000032:analysis*
D014527:Uric Acid