title: Lipopolysaccharide-induced monocytic cell death for the diagnosis of mild neonatal-onset multisystem inflammatory disease.
abstract: In this report, we describe a boy who showed mild symptoms of neonatal-onset multisystem inflammatory disease. Although his symptoms and laboratory findings were similar to those of systemic juvenile idiopathic arthritis, further examinations revealed papilledema, meningitis, and a NLRP3 mutation. His peripheral blood monocytes died within 24 hours after lipopolysaccharide stimulation, a test that may be useful for diagnosis even in mild cases.
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. takadah@pediatr.med.kyushu-u.ac.jp
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Takada
authors.forename: Masataka
authors.initials: M
authors.lastname: Ishimura
authors.forename: Hiroko
authors.initials: H
authors.lastname: Inada
authors.forename: Shouichi
authors.initials: S
authors.lastname: Ohga
authors.forename: Koichi
authors.initials: K
authors.lastname: Kusuhara
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Moroi
authors.forename: Masutaka
authors.initials: M
authors.lastname: Furue
authors.forename: Toshiro
authors.initials: T
authors.lastname: Hara
mesh_terms: D016923:Cell Death; D002648:Child; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D009000:Monocytes / Q000187:drug effects*; D012720:Severity of Illness Index
chemical_list: D008070:Lipopolysaccharides