[Genetic polymorphism of sperm-specifically expressed genes and male infertility].
The expression of sperm-specific genes is necessary in spermiogenesis, and the genetic polymorphism of these genes may impair spermatogenesis, leading to male infertility. Mamy investigations have been conducted on the polymorphism of some candidate genes that are specifically expressed in spermiogenesis, the relation of genetic polymorphism with male infertility and its possible mechanism. Further attempts have been made at the explanation of the causes of infertility from the genetic angle.
Li
Bo
B
Reaserch Center for Molecular Medicine, Fuzhou General Hospital of Nanjing Military Region/Fuzong Clinical College of Fujian Medical Univercity, Fuzhou, Fujian 350025, China. zhaoqingli2000@163.com
Lan
Feng-Hua
FH
D000469:Alkaline Phosphatase / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D013091:Spermatogenesis / Q000235:genetics; D013094:Spermatozoa / Q000378:metabolism*
D004268:DNA-Binding Proteins; C409745:ZNF214 protein, human; D000469:Alkaline Phosphatase