title: Contribution of h-bonding to the preference of platinum anti-tumour drugs for particular bases and particular cross-links.
abstract: The stereochemical factors that influence the tendencies for sequence specific binding of platinum antitumour drugs to DNA are examined. The NHs of the platinum-amine moiety can form hydrogen bonds to the O6 of guanine or to a phosphate oxygen of DNA. Modelling the stereochemistry of the NH atoms can lead to compounds with a strong preference for forming one type of adduct with DNA.
authors.affiliation: Dipartimento Farmaco-Chimico via E. Orabona 4 Bari I-70125 Italy.
authors.forename: G
authors.initials: G
authors.lastname: Natile