title: Association of the myeloperoxidase polymorphism with the risk of gastric cancer.
abstract: BACKGROUND
  The myeloperoxidase in neutrophils manufactures many bactericidal oxidants. The aim of this study was to clarify the relations between the myeloperoxidase polymorphism and gastric cancer development.
  
  
  METHODS
  In a case control study of 157 consecutive gastric cancer patients and 192 controls, the myeloperoxidase -463G-->A polymorphism was genotyped. Additionally, gastric mucosal changes were examined according to the updated Sydney System.
  
  
  RESULTS
  The carriage of myeloperoxidase allele A, male gender, advanced age, high intake of salty food and Helicobacter pylori infection independently increased the risk of gastric cancer [95% confidence interval (CI): 1.5-5.0, 1.7-6.5, 2.6-8.6, 1.1-2.6 and 1.2-3.8, respectively]. H. pylori-infected individuals who were carriers of myeloperoxidase allele A had increased risks of both intestinal and diffuse types of gastric cancer with odds ratios of 7.9 (95% CI 2.6-23.5) and 8.6 (95% CI 2.0-36.7), respectively. In the H. pylori-infected individuals, allele A carriers displayed higher scores of bacterial density (p=0.02) and neutrophil infiltration (p=0.05) in the antrum and higher scores of neutrophil infiltration (p=0.02) and gland atrophy (p=0.03) in the corpus than did non-carriers.
  
  
  CONCLUSIONS
  This study verifies the association of myeloperoxidase -463G-->A polymorphism with gastric cancer. The mechanisms underlying this genetic polymorphism in developing gastric cancer merit further investigations.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
authors.forename: Ping-I
authors.initials: PI
authors.lastname: Hsu
authors.forename: Jyh-Jen
authors.initials: JJ
authors.lastname: Jwo
authors.forename: Chia-Lin
authors.initials: CL
authors.lastname: Yang
authors.forename: Ping-Ning
authors.initials: PN
authors.lastname: Hsu
authors.forename: Hsiao-Bai
authors.initials: HB
authors.lastname: Yang
authors.forename: Kwok-Hung
authors.initials: KH
authors.lastname: Lai
authors.forename: I-Shu
authors.initials: IS
authors.lastname: Chen
authors.forename: Seng-Kee
authors.initials: SK
authors.lastname: Chuah
authors.forename: Deng-Chyang
authors.initials: DC
authors.lastname: Wu
authors.forename: Angela
authors.initials: A
authors.lastname: Chen
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005756:Gastritis / Q000201:enzymology / Q000235:genetics / Q000382:microbiology; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000201:enzymology / Q000235:genetics; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000382:microbiology / Q000473:pathology
chemical_list: D009195:Peroxidase