title: Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha.
abstract: Synthesis of IL-1beta and TNFalpha by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC(50) values in the muM range. The results indicate that these compounds may have value in the therapy of human diseases where these inflammatory cytokines have a central role in pathogenesis.
authors.affiliation: lmmunobiology Laboratory The University of Queensland Dental School Brisbane 4000 Australia.
authors.forename: W K
authors.initials: WK
authors.lastname: Seow
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Sugimura
authors.forename: Y
authors.initials: Y
authors.lastname: Sugimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: D P
authors.initials: DP
authors.lastname: Fairlie
authors.forename: Y H
authors.initials: YH
authors.lastname: Thong