Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029.
Five new preussomerin analogues, ymf 1029A (1), B (2), C (3), D (4), and E (5), were isolated from the liquid cultures of an unidentified freshwater fungus YMF 1.01029, along with four known compounds, preussomerin C (6), preussomerin D (7), (4RS)-4,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one (8), and 4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one (9). The structures of new metabolites were determined by analysis of NMR and MS data and by analogy with the data for the known bis-spirobisnaphthalene preussomerins. In vitro immersion experiments showed that these metabolites displayed weak nematicidal activity against Bursaphelenchus xylophilus, while compound 7 was the most potent. This is the first report of these compounds, which antagonize the Bursaphelenchus xylophilus nematode.
Dong
Jin Yan
JY
Laboratory for ConserVation and Utilization of Bio-Resources, Yunnan University, Kunming 650091, People's Republic of China.
Song
Hong Chuan
HC
Li
Jian Hua
JH
Tang
Yu Shu
YS
Sun
Rong
R
Wang
Le
L
Zhou
Yong Ping
YP
Wang
Li Mei
LM
Shen
Kai Ze
KZ
Wang
Chun Ren
CR
Zhang
Ke-Qin
KQ
D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005618:Fresh Water / Q000382:microbiology; D005658:Fungi / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007559:Ivermectin / Q000031:analogs & derivatives / Q000494:pharmacology; D015394:Molecular Structure; D009348:Nematoda / Q000187:drug effects; D014197:Trees / Q000382:microbiology
D000969:Antinematodal Agents; D004852:Epoxy Compounds; D006576:Heterocyclic Compounds, 4 or More Rings; C530777:Ymf 1029A; D007559:Ivermectin; C019264:avermectin