title: Langerhans cell histiocytosis: impact on the permanent dentition after an 8-year follow-up.
abstract: Langerhans cell histiocytosis (LCH) is a rare disorder which mainly affects children. Oral changes, such as gingival ulceration, halitosis, osseous lesions associated with tooth mobility, and early loss of primary teeth, comprise the disease's first manifestations for most patients. In the long term, dental changes may occur as a result of dental and systemic treatment. Therefore, this study's purpose is to report Langerhans cell histiocytosis' effects on the permanent dentition 8 years after diagnosis, which had been established by performing a biopsy of gingival tissue on a 3-year-old patient.
authors.affiliation: Department of Paediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Lizandra Ferrari
authors.initials: LF
authors.lastname: Guimarães
authors.forename: Patricia Fernanda Barros Pereira
authors.initials: PF
authors.lastname: Dias
authors.forename: Maria Elisa
authors.initials: ME
authors.lastname: Janini
authors.forename: Ivete Pomarico Ribeiro
authors.initials: IP
authors.lastname: de Souza
mesh_terms: D000848:Anodontia / Q000209:etiology; D002675:Child, Preschool; D003744:Dental Enamel Hypoplasia / Q000209:etiology; D019229:Dentition, Permanent; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000209:etiology*; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications*; D006801:Humans; D008297:Male; D008313:Malocclusion, Angle Class III / Q000209:etiology*