title: Outcomes in HIV-infected patients who develop tuberculosis after starting antiretroviral treatment in Malawi.
abstract: A retrospective review was conducted of patients starting antiretroviral treatment (ART) at Mzuzu Central Hospital, Malawi, to identify those who developed tuberculosis (TB) within 6 months of commencing ART and document their treatment outcomes. Of 2933 patients, 22 (0.75%) developed active TB, 17 (77%) of whom had commenced ART as a result of unexplained weight loss and/or fever. Of those who developed TB, 41% successfully completed anti-tuberculosis treatment, with lower survival probabilities than patients who did not develop TB. Easier methods are needed to diagnose TB in human immunodeficiency virus-infected patients and to prevent patients from developing TB while on ART.
authors.affiliation: Taiwan Medical Mission in Malawi, International Cooperation and Development Fund, Taipei, Taiwan.
authors.forename: J K-L
authors.initials: JK
authors.lastname: Yu
authors.forename: C-N
authors.initials: CN
authors.lastname: Bong
authors.forename: S C-C
authors.initials: SC
authors.lastname: Chen
authors.forename: R
authors.initials: R
authors.lastname: Dzimadzi
authors.forename: D-Y
authors.initials: DY
authors.lastname: Lu
authors.forename: S D
authors.initials: SD
authors.lastname: Makombe
authors.forename: E J
authors.initials: EJ
authors.lastname: Schouten
authors.forename: K
authors.initials: K
authors.lastname: Kamoto
authors.forename: A D
authors.initials: AD
authors.lastname: Harries
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D002648:Child; D015897:Comorbidity; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008295:Malawi; D012189:Retrospective Studies; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology* / Q000401:mortality
chemical_list: D044966:Anti-Retroviral Agents; D000995:Antitubercular Agents; D007538:Isoniazid