Beta-papillomavirus infection and skin cancer.
The development of highly sensitive PCR techniques and multiplex bead-based Luminex platforms has accelerated the search for a specific role of human papilloma viruses in the development of squamous cell carcinoma. Human papillomaviruses are most likely indirectly involved in this process by facilitating UV-related carcinogenesis via preventing UV-induced apoptosis or impairing DNA repair, but other mechanisms are also possible.
Bouwes Bavinck
Jan Nico
JN
Department of Dermatology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. j.n.bouwes_bavinck@lumc.nl
Plasmeijer
Elsemieke I
EI
Feltkamp
Mariet C W
MC
D052686:Betapapillomavirus / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D004260:DNA Repair; D015972:Gene Expression Regulation, Neoplastic; D015967:Gene Expression Regulation, Viral; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control / Q000821:virology; D020411:Oligonucleotide Array Sequence Analysis; D030361:Papillomavirus Infections / Q000150:complications* / Q000473:pathology; D012878:Skin Neoplasms / Q000201:enzymology / Q000473:pathology*; D014412:Tumor Virus Infections / Q000150:complications / Q000821:virology; D014466:Ultraviolet Rays