title: Causes of hair loss and the developments in hair rejuvenation.
abstract: Hair is considered to be a major component of an individual's general appearance. The psychological impact of hair loss results in a measurably detrimental change in self-esteem and is associated with images of reduced worth. It is not surprising that both men and women find hair loss a stressful experience. Genetic hair loss is the major problem affecting men and by the age of 50, up to 50% will be affected. Initial attempts to regenerate the lost hair have centred on applying a topical solution of between 2% to 5% minoxidil; however, the results proved disappointing. Recently, finasteride, a type II 5alpha reductase inhibitor has been found to regrow a noticeable amount of hair in about 40% of balding men. Further developments in treatments have lead to the use of a dual type I and type II inhibitor where 90% of those treated regrow a noticeable amount of hair. In women the major cause of hair loss before the age of 50 is nutritional, with 30% affected. Increased and persistent hair shedding (chronic telogen effluvium) and reduced hair volume are the principle changes occurring. The main cause appears to be depleted iron stores, compromised by a suboptimal intake of the essential amino acid l-lysine. Correction of these imbalances stops the excessive hair loss and returns the hair back to its former glory. However, it can take many months to redress the situation.
authors.affiliation: University of Portsmouth, Portsmouth, Hants PO1 2DT, UK. rushton@btinternet.com
authors.forename: D H
authors.initials: DH
authors.lastname: Rushton
authors.forename: M J
authors.initials: MJ
authors.lastname: Norris
authors.forename: R
authors.initials: R
authors.lastname: Dover
authors.forename: Nina
authors.initials: N
authors.lastname: Busuttil