Poised RNA polymerase II gives pause for thought.
Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes are in fact regulated after recruitment of Pol II, by mechanisms such as pausing of Pol II proximal to promoters.
Margaritis
Thanasis
T
Department of Physiological Chemistry, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
Holstege
Frank C P
FC
D000818:Animals; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D008957:Models, Genetic; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000378:metabolism*; D014158:Transcription, Genetic
D012319:RNA Polymerase II