Hyperhomocysteinemia and retinal vascular changes in patients with epilepsy.
The possible occurrence of asymptomatic retinal vascular damage was investigated in 87 hyperhomocysteinemic (plasma total homocysteine >13micromol/L) adult epileptic patients (46 M, 41 F; age 34.2+/-7.5 years; mean plasma homocysteine levels 29.8+/-15.4micromol/L; duration of epilepsy 11.5+/-2.4 years) with no other risk factors for atherosclerosis. Plasma total homocysteine (t-Hcy) levels were assayed by high performance liquid chromatography. Retina vascular status was assessed by fundus oculi ophthalmoscopy performed in blind conditions by two skilled ophthalmologists and compared with that obtained from 102 randomly chosen epileptic patients and 94 healthy subjects, matched for age and sex, showing normal t-Hcy levels. No retina abnormality was detected in any of the subjects belonging to the three groups. Based on these results, we conclude that epileptic patients with mild to intermediate hyperhomocysteinemia are not at risk to develop retinal vascular disease.
Belcastro
Vincenzo
V
Neurology Clinic, University of Perugia, Italy. vincenzobelcastro@libero.it
Striano
Pasquale
P
Caccamo
Daniela
D
Costa
Cinzia
C
Pisani
Laura Rosa
LR
Trombetta
Costantino John
CJ
Maddaloni
Aldo
A
Ciampa
Clotilde
C
Reccia
Raffaele
R
Ientile
Riccardo
R
Striano
Salvatore
S
Calabresi
Paolo
P
Pisani
Francesco
F
D000328:Adult; D016022:Case-Control Studies; D004827:Epilepsy / Q000150:complications* / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012160:Retina / Q000473:pathology; D031300:Retinal Vasculitis / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D012171:Retinal Vessels / Q000473:pathology; D016037:Single-Blind Method; D055815:Young Adult