Anergic signals: the action is upstream.
The molecular mechanisms that underlie T cell anergy remain unclear. In this issue of Immunity, Teague et al. (2008) report that anergy may occur at the level of T cell receptor complex.
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Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. hg2065@columbia.edu
D000818:Animals; D017252:CD3 Complex / Q000276:immunology* / Q000378:metabolism; D017635:Clonal Anergy; D008213:Lymphocyte Activation; D051379:Mice; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D011948:Receptors, Antigen, T-Cell / Q000276:immunology* / Q000378:metabolism; D017634:Self Tolerance; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D013950:Thymus Gland / Q000276:immunology
D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell