title: The ubiquitin ligase gene (WWP1) is responsible for the chicken muscular dystrophy.
abstract: Chicken muscular dystrophy with abnormal muscle (AM) has been studied for more than 50 years, but the gene responsible for it remains unclear. Our previous studies narrowed down the AM candidate region to approximately 1Mbp of chicken chromosome 2q containing seven genes. In this study, we performed sequence comparison and gene expression analysis to elucidate the responsible gene. One missense mutation was detected in AM candidate genes, while no remarkable alteration of expression patterns was observed. The mutation was identified in WWP1, detected only in dystrophic chickens within several tetrapods. These results suggested WWP1 is responsible for chicken muscular dystrophy.
authors.affiliation: Graduate School of Science and Technology, Kobe University, Kobe 657-8501, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Hideaki
authors.initials: H
authors.lastname: Maruse
authors.forename: Yumi
authors.initials: Y
authors.lastname: Inaba
authors.forename: Kanako
authors.initials: K
authors.lastname: Yoshizawa
authors.forename: Shinji
authors.initials: S
authors.lastname: Sasazaki
authors.forename: Akira
authors.initials: A
authors.lastname: Fujiwara
authors.forename: Masahide
authors.initials: M
authors.lastname: Nishibori
authors.forename: Akinori
authors.initials: A
authors.lastname: Nakamura
authors.forename: Shin'ichi
authors.initials: S
authors.lastname: Takeda
authors.forename: Nobutsune
authors.initials: N
authors.lastname: Ichihara
authors.forename: Tateki
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Fumio
authors.initials: F
authors.lastname: Mukai
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Mannen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens / Q000235:genetics*; D015870:Gene Expression; D008969:Molecular Sequence Data; D009137:Muscular Dystrophy, Animal / Q000235:genetics*; D020125:Mutation, Missense; D011201:Poultry Diseases / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
chemical_list: D044767:Ubiquitin-Protein Ligases