Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities.
TRIM5alpha is a potent barrier to cross-species retroviral transmission, and TRIM5alphas from different species have divergent antiretroviral specificities. Multiple TRIM5 alleles circulate within rhesus macaque populations. Here we show that they too have different antiretroviral specificities, highlighting how TRIM5 genotypes contribute to protection in an individual or a population.
Wilson
Sam J
SJ
Medical Research Council Centre for Medical Molecular Virology, Division of Infection and Immunity, University College and Royal Free Medical School, University College London, 46 Cleveland Street, London W1T4JF, United Kingdom.
Webb
Benjamin L J
BL
Maplanka
Charlotte
C
Newman
Ruchi M
RM
Verschoor
Ernst J
EJ
Heeney
Jonathan L
JL
Towers
Greg J
GJ
D000483:Alleles; D000818:Animals; D008253:Macaca mulatta / Q000235:genetics* / Q000276:immunology*; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics* / Q000276:immunology*; D044767:Ubiquitin-Protein Ligases
D011506:Proteins; C482587:TRIM5(alpha) protein, rhesus monkey; D044767:Ubiquitin-Protein Ligases