[Chemotherapy activity and pharmacokinetics of the fluoroquinolones generics Ofloxacin-PhPO and Pefloxacin-genova].
Therapeutic activity, pharmacokinetic and bioavailability on animals (inbred white mouse, rabbits) were evaluated for Ofloxacin-PhPO and Pefloxacin-genova in comparison with innovator products--Tarivid and Abaktal. The results of the experiments demonstrate that investigated generics by their therapeutic efficacy in animals and by bioavailability are similar to original products.
Ptitsina
S N
SN
Bobrov
V I
VI
Borisov
M M
MM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D016568:Drugs, Generic / Q000493:pharmacokinetics; D008297:Male; D051379:Mice; D015242:Ofloxacin / Q000493:pharmacokinetics*; D015366:Pefloxacin / Q000493:pharmacokinetics*; D011817:Rabbits
D000900:Anti-Bacterial Agents; D016568:Drugs, Generic; D015366:Pefloxacin; D015242:Ofloxacin