Cardiac (31)P-MRS compared to echocardiographic findings in patients with hypertensive heart disease without overt systolic dysfunction--preliminary results.
OBJECTIVE
To evaluate changes in high energy phosphate (HEP) metabolism in patients with hypertension and diastolic dysfunction but with normal LVEF>55% assessed by echocardiography and tissue Doppler.


METHODS
20 patients (16 men and 4 women, mean age 57+/-13 years) were studied with phosphorus magnetic resonance spectroscopy and echocardiography. MRS was performed at 1.5T using an ECG-gated CSI sequence with nuclear Overhauser effect. According to echocardiographical findings 12 patients were found to have a diastolic dysfunction, whereas 8 patients were identified as normal, serving as control group in the following statistical analysis. All patients had normal systolic function (LVEF>55%).Statistical analysis was made by using mean+/-S.D. for description of the data, Spearman correlation and two-tailed Student's t-test for independent samples.


RESULTS
No differences were found in weight, age, LVEF, endsystolic volume, end-diastolic volume, cardiac output and BNP levels between patients and control group. Myocardial mass at end-diastole correlated significantly with PCr/ATP ratio (r=-0.66; p=0.04) in patients and control group. Myocardial PCr/ATP ratio in patients was significantly decreased compared to controls (1.21+/-0.22 vs. 1.54+/-0.24; p=0.006).


CONCLUSIONS
Cardiac (31)P-MRS might offer a noninvasive means for detecting early states of heart failure in hypertensive patients.
Burkhard
Thorsten
T
Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt/Main, Theodor-Stern-Kai 7, Frankfurt/Main 60590, Germany. Thorsten.Burkhard@web.de
Herzog
Christopher
C
Linzbach
Sven
S
Spyridopoulos
Ioakim
I
Huebner
Frank
F
Vogl
Thomas J
TJ
D000293:Adolescent; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D010710:Phosphates / Q000032:analysis*; D010759:Phosphorus Isotopes / Q000493:pharmacokinetics; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism
D010710:Phosphates; D010759:Phosphorus Isotopes