title: [Spontaneous regression of lung metastases from renal cell carcinoma: the importance of immunogenetic factors and a review of the literature].
abstract: Spontaneous regression of renal cell cancer (RCC) metastases most frequently occurs after nephrectomy, since reducing target size makes possible a more effective immune response. RCC is immunotherapy-sensitive, as are RCC metastases, especially metastases to the lungs (organs are rich in immune cells and continually exposed to antigens), which have an antigenic effect. Immunotherapy could be perfected if a renal antigen that could be incorporated into a vaccine were identified. This would have played an important role in treatment and follow-up. Vaccine therapy for RCC is no longer far out of reach. The characteristics of RCC make it a fertile field for the study of prometastatic and endogenous antiangiogenic factors.
authors.affiliation: Dipartimento di Area Critica, Medico Chirurgica Urologia I, Università degli Studi di Firenze, viale Pieraccini 18, Florence, Italy. Alfonso.crisci@unifi.it
authors.forename: A
authors.initials: A
authors.lastname: Crisci
authors.forename: I
authors.initials: I
authors.lastname: Corsale
authors.forename: F
authors.initials: F
authors.lastname: Abrami
authors.forename: L
authors.initials: L
authors.lastname: Politi
authors.forename: M
authors.initials: M
authors.lastname: Andreani
authors.forename: S
authors.initials: S
authors.lastname: Borgianni
authors.forename: D
authors.initials: D
authors.lastname: Barale
authors.forename: B
authors.initials: B
authors.lastname: Porfirio
mesh_terms: D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000276:immunology / Q000556:secondary*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000235:genetics / Q000276:immunology / Q000556:secondary*; D009365:Neoplasm Regression, Spontaneous / Q000235:genetics / Q000276:immunology