title: Potential role of the ubiquitin-proteasome system in atherosclerosis: aspects of a protein quality disease.
abstract: Misfolded or damaged proteins are recognized intracellularly by protein quality mechanisms. These include chaperones and the ubiquitin-proteasome system, which aim at restoration of protein function and protein removal, respectively. A number of studies have outlined the functional significance of the ubiquitin-proteasome system for the heart and, as of recently, for the vascular system. This review summarizes these recent findings with a focus on atherosclerosis. In particular, this paper reflects on the viewpoint of atherosclerosis as a protein quality disease.
authors.affiliation: Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. joerg@mayo.edu
authors.forename: Joerg
authors.initials: J
authors.lastname: Herrmann
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Soares
authors.forename: Lilach O
authors.initials: LO
authors.lastname: Lerman
authors.forename: Amir
authors.initials: A
authors.lastname: Lerman
mesh_terms: D050197:Atherosclerosis / Q000503:physiopathology*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000502:physiology*; D011487:Protein Conformation; D017510:Protein Folding; D025801:Ubiquitin / Q000502:physiology; D043743:Ubiquitin-Protein Ligase Complexes / Q000502:physiology*
chemical_list: D025801:Ubiquitin; D043743:Ubiquitin-Protein Ligase Complexes; D046988:Proteasome Endopeptidase Complex