title: Lipomatous mixed tumor of the skin.
abstract: An unusual tumor of the neck in a 56-year-old female is reported. The tumor was composed of tubules and small cords of epithelial cells dispersed in the fibromyxoid and adipose stroma. At the periphery, the tumor was not encapsulated and its border was intermingled with the subcutaneous fat. Lack of decapitation secretion and the absence of long tubules suggested an eccrine origin; however, in some of the tumor areas, the cells showed brightly eosinophilic copious cytoplasm that may indicate an apocrine differentiation. As an area of chondroid metaplasia was identified, the diagnosis of a mixed tumor was rendered. This unusual type of skin adnexal neoplasm with unique relation of the epithelial component to the surrounding adipose tissue requires differentiation with the primary cutaneous and metastatic carcinomas.
authors.affiliation: Department of Neuropathology and Molecular Pathology, Medical University of Gdańsk, Gdańsk, Poland. biernat@amg.gda.pl
authors.forename: Wojciech
authors.initials: W
authors.lastname: Biernat
mesh_terms: D017667:Adipocytes / Q000473:pathology; D000273:Adipose Tissue / Q000737:chemistry / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006258:Head and Neck Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008067:Lipoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis; D018193:Neoplasms, Complex and Mixed / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery; D012878:Skin Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D007633:Keratins