title: Synthesis and biological activity of silyl- and germylsubstituted trifluroacetylfurans.
abstract: A series of silyl, germyl and alkyl substituted trifluoroacetylfurans has been synthesized under Friedel-Crafts electrophilic acylation conditions. Biological investigations have demonstrated that germyl derivatives of trifluoroacetylfuran are more toxic than the silicon analogues. 5-Triethylgermyl-2- trifluoroacetylfuran was the most toxic compound (CD(nabla), 11.2 mg kg(-1), i.p. for white mice), 200 times more toxic than the silicon analogue. 5-t-Butyl- and 5-trimethylsilyl-2-trifluroacetylfuran prolong the duration of ethanol anaesthesia by 220 and 140%. 5-Triethylgermyl-2-trifluroacetylfuran exibited high anesthetic activity in hexobarbital test (prolonged the duration by 137%). Some of compounds influenced muscle tone and locomotor coordination parameters. 5-Triethylgermyl-2-trifluomacetylfuran exibited analgesic activity (D(nabla), 0.9 mg k}(-infinity)).
authors.affiliation: Latvian Institute of Organic Synthesis Aizkraukles 21 Riga LV-1006 Latvia.
authors.forename: L
authors.initials: L
authors.lastname: Ignatovich
authors.forename: D
authors.initials: D
authors.lastname: Zarina
authors.forename: I
authors.initials: I
authors.lastname: Shestakova
authors.forename: S
authors.initials: S
authors.lastname: Germane
authors.forename: E
authors.initials: E
authors.lastname: Lukevics