Sensing intracellular pathogens-NOD-like receptors.
The innate immune system uses different molecules that sense pathogen associated molecular patterns. These include Toll-like receptors (TLRs), RIG-1-like receptors (RLRs) and the NOD-like receptors (NLRs). The NLRs, consisting of more than 20 related family members, are present in the cytosol and recognize intracellular ligands. Members of the NLR can be grouped into molecules that contain either a CARD or a Pyrin motif. The NOD proteins mediate NF-kappaB activation, whereas Pyrin molecules such as NALP3 regulate IL-1beta and IL-18 production. In this review, we will discuss the role of NLRs in pattern recognition of microbial components and their role in health and disease.
Rietdijk
Svend T
ST
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, NL-1105 AZ, The Netherlands. S.T.Rietdijk@Fulbrightweb.org
Burwell
Timothy
T
Bertin
John
J
Coyle
Anthony J
AJ
D000818:Animals; D053468:CARD Signaling Adaptor Proteins / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000209:etiology*; D008024:Ligands; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D053474:Nod1 Signaling Adaptor Protein / Q000737:chemistry / Q000502:physiology*; D053473:Nod2 Signaling Adaptor Protein / Q000737:chemistry / Q000502:physiology*; D051193:Toll-Like Receptors / Q000502:physiology
D053468:CARD Signaling Adaptor Proteins; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D008024:Ligands; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C435692:NLRC4 protein, human; C453881:NLRP3 protein, human; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; D051193:Toll-Like Receptors