title: Insights into the sequence of structural consequences of convulsive status epilepticus: a longitudinal MRI study.
abstract: While acute hippocampal magnetic resonance imaging (MRI) changes have been demonstrated, the long-term structural consequence of status epilepticus remains unclear. Also the timing of previously reported fornix abnormalities in patients with mesial temporal sclerosis (MTS) is unknown. We report longitudinal volumetic MRI and diffusion tensor imaging (DTI) findings of the hippocampus and fornix in a patient following status epilepticus. Left hippocampal atrophy demonstrated progression beyond 6 months poststatus epilepticus while the right hippocampus and bilateral fornices demonstrated stable volumetric and diffusion abnormalities throughout the study. Our findings provide evidence that status epilepticus can induce permanent hippocampal damage with the delayed timing of the structural changes being consistent with programmed cell death.
authors.affiliation: Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Gaolang
authors.initials: G
authors.lastname: Gong
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.forename: Luis
authors.initials: L
authors.lastname: Concha
authors.forename: Christian
authors.initials: C
authors.lastname: Beaulieu
authors.forename: Donald W
authors.initials: DW
authors.lastname: Gross
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D004569:Electroencephalography; D005260:Female; D020712:Fornix, Brain / Q000473:pathology; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D012598:Sclerosis / Q000473:pathology; D012720:Severity of Illness Index; D013226:Status Epilepticus / Q000175:diagnosis / Q000503:physiopathology*; D013702:Temporal Lobe / Q000473:pathology