Actin nucleation: putting the brakes on Arp2/3.
The Arp2/3 complex is a powerful nucleator of actin filaments when activated. A recent study has now revealed that this complex is not only subject to positive control but that there also exists a brake on its activity. This brake can suppress both the basal activity of the Arp2/3 complex as well as its activation by nucleation-promoting factors.
Qualmann
Britta
B
Institute for Biochemistry I, Friedrich-Schiller-University Jena, 07743 Jena, Germany. Electronic address: britta.qualmann@mti.uni-jena.de.
Kessels
Michael M
MM
Institute for Biochemistry I, Friedrich-Schiller-University Jena, 07743 Jena, Germany.
D008841:Actin Cytoskeleton / Q000378:metabolism*; D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism*; D000199:Actins / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D003598:Cytoskeletal Proteins; D009687:Nuclear Proteins / Q000378:metabolism*; D051381:Rats; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal / Q000378:metabolism
D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D009687:Nuclear Proteins; C498298:PICK1 protein, rat; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal