Antioxidant properties of oxime 3-(phenylhydrazono) butan-2-one.
Oximes are a class of compounds normally used to reverse the acetylcholinesterase (AChE) inhibition caused by organophosphates (OPs). Conversely, researches focusing on the possible antioxidant properties of these compounds are lacking in the literature. The aim of this study was to investigate the potential antioxidant and toxic properties of 3-(phenylhydrazono) butan-2-one oxime in mice. In vitro, hydrogen peroxide-induced lipid peroxidation was decreased by low concentrations of the oxime (0.1-1.0 microM); (P < 0.05). Similarly, lipoperoxidation induced by malonate and iron (Fe2+) was significantly decreased by the oxime (0.4-1.0 microM) (P < 0.05). Oxime pre-treatment did not modify the basal peroxidation level nor prevented the induced lipid peroxidation determined ex-vivo. The present results suggest that 3-(phenylhydrazono) butan-2-one oxime could be a good antioxidant compound. The absence of toxicity signs after in vivo administration of 3-(phenylhydrazono) butan-2-one oxime to mice may indicate that it could be a safe drug for further studies.
Puntel
Gustavo Orione
GO
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus UFSM, Santa Maria, RS 97105-900, Brazil.
Gubert
Priscila
P
Peres
Gisele Louro
GL
Bresolin
Leandro
L
Rocha
João Batista Teixeira
JB
Pereira
Maria Ester
ME
Carratu
Vanessa Santana
VS
Soares
Félix A Antunes
FA
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000633:toxicity; D001713:Biphenyl Compounds; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D003855:Deoxyribose / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D007502:Iron Chelating Agents / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008314:Malonates / Q000378:metabolism; D051379:Mice; D010091:Oximes / Q000494:pharmacology* / Q000633:toxicity; D010851:Picrates / Q000737:chemistry; D000623:Porphobilinogen Synthase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
C533883:3-(phenylhydrazono) butan-2-one oxime; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D007502:Iron Chelating Agents; D008314:Malonates; D010091:Oximes; D010851:Picrates; D017392:Thiobarbituric Acid Reactive Substances; D003855:Deoxyribose; C030290:malonic acid; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl; D007501:Iron; D000623:Porphobilinogen Synthase