Pyridoxine induced neuropathy by subcutaneous administration in dogs.
To construct a sensory neuropathy model, excess pyridoxine (150 mg/kg s.i.d.) was injected subcutaneously in dogs over a period of 7 days. During the administrations period, the dogs experienced body weight reduction and proprioceptive loss involving the hindquarters. After pyridoxine administration was completed, electrophysiological recordings showed that the M wave remained at a normal state, but the H-reflex of the treated dogs disappeared at 7 days. The dorsal funiculus of L(4) was disrupted irregularly in the axons and myelin with vacuolation. The dorsal root ganglia of L(4), and sciatic and tibial nerves showed degenerative changes and vacuolation. However, the lateral and ventral funiculi of L(4) showed a normal histopathologic pattern. Although this subcutaneous administration method did not cause systemic toxicity and effectively induced sensory neuropathy, this study confirmed the possibility of producing a pyridoxine-induced sensory neuropathy model in dogs with short-term administration.
Chung
Jin-Young
JY
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
Choi
Jung-Hoon
JH
Hwang
Cheol-Yong
CY
Youn
Hwa-Young
HY
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D004285:Dogs; D004594:Electrophysiology; D019636:Neurodegenerative Diseases / Q000139:chemically induced* / Q000473:pathology; D011434:Proprioception / Q000187:drug effects; D011736:Pyridoxine / Q000633:toxicity*
D011736:Pyridoxine