Antipsychotics and hyperprolactinaemia: clinical recommendations.
A group of international experts in psychiatry, medicine, toxicology and pharmacy assembled to undertake a critical examination of the currently available clinical guidance on hyperprolactinaemia. This paper summarises the group's collective views and provides a summary of the recommendations agreed by the consensus group to assist clinicians in the recognition, clinical assessment, investigation and management of elevated plasma prolactin levels in patients being treated for severe mental illness. It also deals with the special problems of particular populations, gives advice about information that should be provided to patients, and suggests a strategy for routine monitoring of prolactin. The recommendations are based upon the evidence contained in the supplement 'Hyperprolactinaemia in schizophrenia and bipolar disorder: Clinical Implications' (2008). The guidance contained in this article is not intended to replace national guidance (such as that of the National Institute of Clinical Excellence), however, it does provide additional detail that is unlikely to be covered in existing guidelines, and focuses on areas of uncertainty and disagreement. We hope it will add to the debate about this topic.
Peveler
Robert C
RC
University of Southampton, Royal South Hants Hospital, Southampton, UK. rcp@soton.ac.uk
Branford
David
D
Citrome
Leslie
L
Fitzgerald
Peter
P
Harvey
Philip W
PW
Holt
Richard I G
RI
Howard
Louise
L
Kohen
Dora
D
Jones
Ian
I
O'Keane
Veronica
V
Pariente
Carmine M
CM
Pendlebury
John
J
Smith
Shubulade M
SM
Yeomans
David
D
D014150:Antipsychotic Agents / Q000009:adverse effects*; D035843:Biomedical Research; D015519:Bone Density / Q000187:drug effects; D016903:Drug Monitoring; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced* / Q000150:complications / Q000378:metabolism / Q000628:therapy; D001523:Mental Disorders / Q000188:drug therapy* / Q000378:metabolism; D010353:Patient Education as Topic; D017410:Practice Guidelines as Topic; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D009626:Terminology as Topic
D014150:Antipsychotic Agents; D011388:Prolactin