title: Gamma Knife surgery for invasive pituitary macroadenoma.
abstract: OBJECTIVE
  Pituitary adenomas have been treated using a variety of modalities including resection, medication, fractionated radiotherapy, and stereotactic radiosurgery. The policy has been that all adenomas should first be treated with resection to reduce the volume of the tumor. The authors' study was conducted to determine the efficacy of using Gamma Knife surgery (GKS) for pituitary adenomas invading the cavernous sinus.
  
  
  METHODS
  Of 397 patients with pituitary tumors who underwent GKS between October 1994 and October 2005, 68 patients had pituitary macroadenomas invading the cavernous sinus. Sixty-seven cases were available for follow up. The mean age of the patients in these cases was 42.8 years (range 14-73 years). The male/female ratio was 0.8:1. The mean adenoma volume was 9.3 cm3. A total of 24 patients had undergone craniotomies and resection, and 11 patients had undergone transsphenoidal surgery prior to GKS. The mean follow-up period was 32.8 months. Tumor control was defined as a decrease or no change in tumor volume after GKS. Endocrinological improvement was defined as a decline in hormone levels to below 50% of the pre-GKS level. Tumor control was achieved in 95.5% of the cases. Endocrinological improvement was achieved in 68% of 25 patients. One patient suffered hypopituitarism after GKS.
  
  
  CONCLUSIONS
  Gamma Knife surgery is a safe and effective treatment for invasive pituitary macroadenoma with few complications.
authors.affiliation: Department of Neurosurgery, College of Medicine, Inje University Busan Paik Hospital, Busan, Korea. hja319@hanmail.net
authors.forename: Mooseong
authors.initials: M
authors.lastname: Kim
authors.forename: Sunghwa
authors.initials: S
authors.lastname: Paeng
authors.forename: Seyoung
authors.initials: S
authors.lastname: Pyo
authors.forename: Yeonggyun
authors.initials: Y
authors.lastname: Jeong
authors.forename: Sunil
authors.initials: S
authors.lastname: Lee
authors.forename: Yongtae
authors.initials: Y
authors.lastname: Jung
mesh_terms: D000236:Adenoma / Q000473:pathology* / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002426:Cavernous Sinus; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010911:Pituitary Neoplasms / Q000473:pathology* / Q000601:surgery*; D016634:Radiosurgery; D012189:Retrospective Studies; D016896:Treatment Outcome; D047368:Tumor Burden; D055815:Young Adult