New polyunsaturated fatty acid amides isolated from the seeds of Zanthoxylum piperitum.
Five linear fatty acid amides (1-5) of the sandshool class, including two new compounds, were isolated from Zanthoxylum piperitum seeds. Based on combined spectral analyses, the structures of new compounds 4 and 5 were determined to be 2',3'-dihydroxy-alpha-sanshool and 2',3'-dihydroxy-beta-sanshool, respectively. These compounds exhibited weak cytotoxicity in the A-549 (human lung cancer) cell line.
Jang
Kyoung Hwa
KH
College of Pharmacy, Seoul National University, Seoul, 110-460, Korea.
Chang
Yong Ha
YH
Kim
Dae-Duk
DD
Oh
Ki-Bong
KB
Oh
Uhtaek
U
Shin
Jongheon
J
D000577:Amides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D032106:Zanthoxylum / Q000737:chemistry*
D000577:Amides; D003603:Cytotoxins; D005231:Fatty Acids, Unsaturated; C100574:sanshool