title: Evaluation of the efficacy of a small CdTe gamma-camera for sentinel lymph node biopsy.
abstract: We previously reported the basic performance of a prototype small cadmium telluride (CdTe) gamma-camera (SSGC) intended for use in radioguided surgeries. In this study, we sought to confirm the favorable previous results and to extend the preliminary findings to examine the efficacy of the SSGC in an animal study and a clinical setting for sentinel lymph node biopsy.
  
  
  METHODS
  The prototype SSGC (1,024 pixels; field of view, 44.8 x 44.8 mm), equipped with a parallel-hole collimator, was used in both animal and clinical studies. 99mTc-phytate (18.5 MBq) was injected into the tongues and legs of 6 rabbits. In the clinical study, 74 MBq of 99mTc-phytate was injected into peritumoral regions in 8 patients with oral cancer. The detection of hot nodes by the SSGC was compared with that by a conventional scintillation gamma-camera (CGC).
  
  
  RESULTS
  The SSGC detected 29 hot nodes in images of 6 rabbits after injection. The number of hot nodes was the same as the number seen in CGC studies, but the CGC required a longer acquisition time to produce comparable images. There were no differences between the SSGC and the CGC in terms of activity ratios and hot node-to-background ratios. The biodistribution of 99mTc-phytate in removed tissues was evaluated by contact radiography, and radioactivity was assayed with a gamma-well counter. The mean +/- SD radioactivity in specimens was 0.15% +/- 0.15%, with a range of 0.01%-0.62%. In the clinical study, the SSGC detected 30 hot nodes with a 5- to 60-s acquisition time at 4 h after injection. The SSGC documented all hot nodes depicted by the CGC at 4 h after injection.
  
  
  CONCLUSIONS
  The SSGC showed significant potential for the detection of sentinel lymph nodes in lymphoscintigraphy. The results of the studies suggested that the SSGC facilitates the exploration of hot nodes in sentinel lymph node biopsy.
authors.affiliation: Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan. tsuchimochi@ngt.ndu.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Tsuchimochi
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Hayama
authors.forename: Takaaki
authors.initials: T
authors.lastname: Oda
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Togashi
authors.forename: Harumi
authors.initials: H
authors.lastname: Sakahara
mesh_terms: D019187:Cadmium Compounds; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013691:Tellurium
chemical_list: D019187:Cadmium Compounds; D013691:Tellurium; C028337:cadmium telluride