title: Cytotoxic Activities of O-Cholesteryl-O-Phenyl-N-Phenylphosphoramidate and Its Organometallic Tin(lV) Derivatives.
abstract: O-Cholesteryl-O-phenyl-N-phenylphosphoramidate (1) and four organotin (lV) derivatives of the ambidentate O-cholesteryl-O -phenyl phosphorothioate ligand formulated as Me(3) SnOSPR'R"(2), Ph(3)SnOSPR'R"(3), O(CH(2)CH(2)S)(2)Sn(n-Bu)OSPR'R"(4), S(CH(2)CH(2)S)(2)Sn(n-Bu)OSPR'R"(5), (R' = O-phenyl; R"= O-cholesteryl) were subjected to cytotoxicity screening against KB (nasopharingel carcinoma), OVCAR-5 (ovarium carcinoma) and SQC-1 UlSO (squamous cell cervix carcinoma) cell cultures. The results of the bioassay showed that these compounds possess potent antitumor activities against the studied human carcinoma cell lines.
authors.affiliation: Center of Chemical Research. Autonomous University of Morelos Av. Universidad 1001 Cuernavaca Morelos 62210 Mexico.
authors.forename: Marcela
authors.initials: M
authors.lastname: López-Cardoso
authors.forename: Patricia García Y
authors.initials: PG
authors.lastname: García
authors.forename: Raymundo
authors.initials: R
authors.lastname: Cea-Olivares
authors.forename: María-Luisa
authors.initials: ML
authors.lastname: Villareal