title: [Thyroid carcinoma with thymus-like differentiation (CASTLE): case report and review of the literature].
abstract: Carcinoma with thymus-like differentiation (CASTLE) is a rare malignant epithelial tumor which arises on soft tissue of the neck or thyroid gland. It is important to differentiate CASTLE from primary or metastatic squamous cell carcinoma of head and neck, and from squamous cell thyroid carcinoma, because it has a different prognosis. CD5 immunoreactivity might be helpful in CASTLE diagnosis. CASTLE behaves generally in an indolent fashion, even though it has a high relapse rate, while the other have a dismal prognosis due its high dissemination rate. Treatment includes surgical excision and radiotherapy. Chemotherapy can be offered, although its efficacy is not clear. Authors present a case of a 52 year-old male that complaints with cough, disphony, asthenia, and thyroid mass. Thyroidectomy was performed and the pathology revealed a CASTLE. After radiotherapy and chemotherapy, minimal response was obtained. The authors intend to discuss the differential pathologic diagnosis and the best therapy of this indolent but recurrent neoplasm, that demands strict long term follow-up.
authors.affiliation: Serviço de Oncologia Médica, Hospital Santa Maria, Lisboa, Portugal. taniaarodrigues@gmail.com
authors.forename: Tânia A
authors.initials: TA
authors.lastname: Rodrigues
authors.forename: António G
authors.initials: AG
authors.lastname: Quintela
authors.forename: Ricardo M
authors.initials: RM
authors.lastname: Luz
authors.forename: Dolores
authors.initials: D
authors.lastname: López
mesh_terms: D002277:Carcinoma / Q000473:pathology* / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology*; D013953:Thymus Neoplasms / Q000473:pathology* / Q000628:therapy; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed