title: Interleukin-2 immediate type hypersensitivity?
abstract: Two patients with metastatic malignant melanoma developed immediate type hypersensitivity-like symptoms while being treated with recombinant interleukin-(IL-)2 immunotherapy. Both patients showed positive skin prick tests to IL-2, enhanced basophil degranulation in vitro and responded to anti-histamines, but laboratory investigations suggested an IgE-independent, pseudoallergic mast cell degranulation against IL-2.
authors.affiliation: Department of Dermatology, Johannes Gutenberg University, Mainz, Germany.
authors.forename: Peri
authors.initials: P
authors.lastname: Caucig
authors.forename: Susanne
authors.initials: S
authors.lastname: Lescau
authors.forename: Jürgen
authors.initials: J
authors.lastname: Knop
authors.forename: Marcus
authors.initials: M
authors.lastname: Maurer
authors.forename: Esther
authors.initials: E
authors.lastname: von Stebut
mesh_terms: D000328:Adult; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
chemical_list: D007376:Interleukin-2