title: The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients.
abstract: The pathogenesis of renal hypertension has not yet been fully clarified. As the potential role of endothelin-1 (ET-1) and nitric oxide (NO) has been postulated, their concentrations were determined in plasma and urine of diabetic patients. The study included 30 diabetic patients (both IDDM and NIDDM) with initial or advanced diabetic nephropathy (decreased endogenous creatinine clearance, proteinuria) and 20 healthy control subjects. The correlation with blood pressure and other renal function parameters was monitored and compared with the control group. Also, the effect of ACE inhibitors (ACEI) on ET-1 and NO patterns was monitored in correlation with arterial hypertension. In diabetic patients that did not receive ACEI therapy, the increase in plasma ET-1 was associated with both systolic and diastolic blood pressure elevation, whereas in those administered ACEI the increase in plasma ET-1 was associated with a systolic blood pressure decline. In addition, the increase in plasma NO was accompanied by a statistically significant decline of both systolic and diastolic blood pressure in diabetic patients receiving ACEI.
authors.affiliation: Department of Nephrology and Hemodialysis, Mostar University Hospital, Mostar, Bosnia and Herzegovina. monika.tomic@gmail.com
authors.forename: Monika
authors.initials: M
authors.lastname: Tomić
authors.forename: Kresimir
authors.initials: K
authors.lastname: Galesić
authors.forename: Jadranka
authors.initials: J
authors.lastname: Morović-Vergles
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Romić
authors.forename: Ivanka
authors.initials: I
authors.lastname: Mikulić
mesh_terms: D000368:Aged; D001794:Blood Pressure; D003928:Diabetic Nephropathies / Q000378:metabolism* / Q000503:physiopathology; D019332:Endothelin-1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*
chemical_list: D019332:Endothelin-1; D009569:Nitric Oxide