title: Corneal ablation with new 193 nm solid-state laser: preliminary experiments.
abstract: OBJECTIVE
  To assess the ability of a newly developed 193 nm solid-state laser to ablate the cornea.
  
  
  METHODS
  Osaka University, Osaka, Japan.
  
  
  METHODS
  A prototype laser engine was developed by combining a 1547 nm laser diode, fiber amplifiers, and 5 stages of a frequency-conversion system using CsLiB6O10 crystals as the last stage. Poly(methyl methacrylate) (PMMA) plates were exposed to the prototype laser beam to determine the relationship between the fluence and ablation rate. Laser irradiation of porcine corneas was performed to induce morphological changes, and the quality of the lesions was determined by light and scanning electron microscopy.
  
  
  RESULTS
  The relationship between the fluence and ablation rate of the 193 nm solid-state laser was comparable to that of the argon-fluoride excimer laser. Light and scanning electron microscopy of the porcine corneas showed that the linear and square lesions had sharp, clean edges.
  
  
  CONCLUSIONS
  Smooth ablations of PMMA plates and porcine corneas were obtained by the laser. Further investigations must be conducted to determine whether this laser can be an alternative laser source for keratorefractive surgery.
authors.affiliation: Department of Ophthalmology, Osaka University Medical School, Suita, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Maeda
authors.forename: Osman
authors.initials: O
authors.lastname: Cekic
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujikado
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Tano
authors.forename: Atsutoshi
authors.initials: A
authors.lastname: Murakami
authors.forename: Masashi
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Mori
authors.forename: Takamoto
authors.initials: T
authors.lastname: Sasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kitano
authors.forename: Soichi
authors.initials: S
authors.lastname: Owa
mesh_terms: D000818:Animals; D003315:Cornea / Q000601:surgery* / Q000648:ultrastructure; D004867:Equipment Design; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008855:Microscopy, Electron, Scanning; D019904:Polymethyl Methacrylate; D054140:Refractive Surgical Procedures / Q000295:instrumentation*; D013552:Swine
chemical_list: D019904:Polymethyl Methacrylate