Molluscicidal activity of 2-hydroxy-[1,4]naphthoquinone and derivatives.
The toxic profile of lawsone (2-hydroxy-[1,4]naphthoquinone) and a series of [1,4]naphthoquinone derivatives was evaluated against the brine shrimp Artemia salina and against the mollusk Biomphalaria glabrata, the main transmitting vector of schistosomiasis in Brazil. Of the seventeen compounds tested nine fell below the threshold of 100 microg/mL set for potential molluscicidal activity by the World Health Organization. As a general rule derivatives with non-polar substituents presented the highest molluscicidal activities. These substances showed significant toxicity in A. salina lethality bioassay.
Camara
Celso A
CA
Departamento de Química, Universidade Federal Rural de Pernambuco, Recife, PE, 52171-030, Brazil.
Silva
Tania M S
TM
da-Silva
Thiago G
TG
Martins
Rodrigo M
RM
Barbosa
Ticiano P
TP
Pinto
Angelo C
AC
Vargas
Maria D
MD
D000818:Animals; D001156:Artemia / Q000187:drug effects*; D001700:Biomphalaria / Q000187:drug effects*; D008975:Molluscacides / Q000138:chemical synthesis / Q000494:pharmacology*; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000494:pharmacology*
D008975:Molluscacides; D009285:Naphthoquinones; C005090:lawsone