title: Combined treatment for multiple cardiac defects with interventional techniques.
abstract: Multiple congenital cardiac defects are usually addressed by cardiac surgery. We present our experience with simultaneous transcatheter treatment of multiple defects in children. Ten children, six females and four males, with multiple defects underwent treatment with interventional technique. The mean age was 4.4 +/- 2.6 years (range, 7 months to 8 years). The cardiac diagnosis was patent ductus arteriosus (PDA) and valvular pulmonary stenosis (PS) in two, atrial septal defect (ASD) and PDA in two, ASD and PS in two, PDA and aortic stenosis (AS) in three (severe left ventricular dysfunction in two), and perimembranous ventricular septal defect (VSD) and valvular PS in one. The ASDs were closed with an Amplatzer septal occluder (mean size, 16 +/- 4 mm), four PDAs were closed with an Amplatzer duct occluder, and three with a Cook's detectable coil. Mean balloon size used to dilate the pulmonary valve was 18 +/- 4 mm, and for the aortic valve this was 12 +/- 2 mm. There was a 70% (+/-15%) postprocedure reduction of gradients across the stenotic valves. The closure rate was 75% for PDAs in the catheterization laboratory, 80% for ASDs, and there was a mild residual intradevice leak in the VSD. In conclusion, interventional technology addressing multiple congenital cardiac defects as a combined procedure in the catheterization laboratory is safe and effective.
authors.affiliation: Pediatric Cardiology, Department of Pediatrics, Aga Khan University Hospital, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan. mehnaz.atiq@aku.edu
authors.forename: Mehnaz
authors.initials: M
authors.lastname: Atiq
authors.forename: Sohail Abraar
authors.initials: SA
authors.lastname: Khan
authors.forename: Fateh Ali
authors.initials: FA
authors.lastname: Tipu
authors.forename: Zahid
authors.initials: Z
authors.lastname: Amin
mesh_terms: D000015:Abnormalities, Multiple / Q000628:therapy*; D006328:Cardiac Catheterization; D002404:Catheterization; D002648:Child; D002675:Child, Preschool; D004374:Ductus Arteriosus, Patent / Q000628:therapy*; D005260:Female; D006330:Heart Defects, Congenital / Q000628:therapy*; D006343:Heart Septal Defects / Q000628:therapy; D006349:Heart Valve Diseases / Q000628:therapy; D006801:Humans; D007223:Infant; D008297:Male; D019736:Prostheses and Implants