title: [Pathogenesis of chronic wounds].
abstract: Chronic, nonhealing wounds and their therapy are not only a medical problem but a severe economic one as well. Such wounds have a great effect on quality of life. Basic research has enhanced our understanding of the stimulation and inhibition of wound healing and provides the basis for introducing new and innovative treatment methods. This paper reviews the most relevant in- and extrinsic factors that disturb physiologic wound healing to result in chronic nonhealing wounds. In addition, molecular intervention modalities targeting various aspects of wound repair are demonstrated.
authors.affiliation: Klinik für Hand-, Plastische und Rekonstruktive Chirurgie, Schwerbrandverletztenzentrum, BG-Unfallklinik Ludwigshafen, Plastische und Handchirurgie der Universität Heidelberg, Ludwigshafen, Deutschland. k_riedel1@gmx.de
authors.forename: K
authors.initials: K
authors.lastname: Riedel
authors.forename: H
authors.initials: H
authors.lastname: Ryssel
authors.forename: E
authors.initials: E
authors.lastname: Koellensperger
authors.forename: G
authors.initials: G
authors.lastname: Germann
authors.forename: T
authors.initials: T
authors.lastname: Kremer
mesh_terms: D002908:Chronic Disease; D016207:Cytokines / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000503:physiopathology; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D012307:Risk Factors; D014945:Wound Healing / Q000502:physiology*; D014946:Wound Infection / Q000503:physiopathology / Q000628:therapy; D014947:Wounds and Injuries / Q000503:physiopathology* / Q000628:therapy
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators