Diverse functions of WD40 repeat proteins in histone recognition.
WD40 repeat proteins have been shown to bind the histone H3 tail at the center of their beta-propeller structure. In contrast, in this issue of Genes & Development, Song and colleagues (pp. 1313-1318) demonstrate that the WD40 repeat protein p55 binds a structured region of H4 through a novel binding pocket on the side of beta-propeller, illustrating a diversity of histone recognition by WD40 repeat proteins.
Suganuma
Tamaki
T
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
Pattenden
Samantha G
SG
Workman
Jerry L
JL
D000818:Animals; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D020449:Repetitive Sequences, Amino Acid / Q000502:physiology*
D006657:Histones; D011506:Proteins