[Grape seed extract inhibits the growth of prostate cancer PC-3 cells].
OBJECTIVE
To investigate the inhibitory effect of grape seed extract (GSE) on the growth of prostate cancer PC-3 cells.


METHODS
PC-3 cells were treated with GSE at the concentration of 100, 200 and 300 microg/ml for 24, 48 and 72 hours, respectively. The the inhibitory effect of GSE on the growth of the PC-3 cells and the kidney cells of SD rats was determined by MTT reduction assay, with primarily cultured kidney cells of 1-3 days old SD rats as the normal control.


RESULTS
GSE significantly inhibited the growth of PC-3 cells in a concentration- and time-dependent manner, but had only a mild inhibitory effect on the kidney cells.


CONCLUSIONS
GSE inhibits the growth of prostate cancer PC-3 cells and can be used as a new drug for the treatment of prostate cancer.
Huang
Ting-Ting
TT
Department of Andrology, Nanjing University School of Clinical Medicine/Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
Shang
Xue-Jun
XJ
Yao
Gen-Hong
GH
Ge
Jing-Ping
JP
Teng
Wen-Hui
WH
Sun
Yi
Y
Huang
Yu-Feng
YF
D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007668:Kidney / Q000166:cytology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011471:Prostatic Neoplasms / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry*; D013997:Time Factors; D027843:Vitis / Q000737:chemistry*
D010936:Plant Extracts