title: Hypotension in anaesthetized patients during aneurysm clipping: not as bad as expected?
abstract: BACKGROUND
  Patients with aneurysmal subarachnoid haemorrhage (SAH) often have disturbed autoregulation of cerebral blood flow. A reduction in systemic blood pressure during surgery may therefore lead to delayed cerebral ischaemia (DCI). To assess the incidence and severity of intra-operative hypotension, we performed a retrospective cohort study in 164 patients with recent SAH and surgical clipping of the aneurysm.
  
  
  METHODS
  Intra-operative hypotension was defined in three levels of severity, as a decrease in mean arterial pressure (DeltaMAP) of more than 30%, 40% or 50% compared with the pre-operative pressure. For each patient the total amount of time with intra-operative hypotension was retrieved. Logistic regression analysis was performed to study the relation between intra-operative hypotension and the occurrence of DCI and poor outcome.
  
  
  RESULTS
  A period with DeltaMAP>30% occurred in 128 patients (78%) with a median duration of this period of 105 min (25-75 per thousand 50-171 min). DeltaMAP>40% occurred in 88 patients (54%) and DeltaMAP>50% occurred in 22 patients (13%). In univariate analysis, DeltaMAP>50% was associated with poor outcome. After adjusting for age and World Federation of Neurological Surgeons grade, the association with poor outcome was no longer statistically significant [odds ratio (OR) 1.018; 95% CI 0.996-1.041].
  
  
  CONCLUSIONS
  Hypotension during surgical clipping of intracranial aneurysms occurred frequently. In our study population of patients mostly in good clinical condition, hypotension was not confirmed as an independent risk factor for DCI or poor outcome. Anaesthesia may have had a cerebral protective effect.
authors.affiliation: Perioperative & Emergency Care, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, the Netherlands. r.hoff@umcutrecht.nl
authors.forename: R G
authors.initials: RG
authors.lastname: Hoff
authors.forename: G W
authors.initials: GW
authors.lastname: VAN Dijk
authors.forename: S
authors.initials: S
authors.lastname: Mettes
authors.forename: B H
authors.initials: BH
authors.lastname: Verweij
authors.forename: A
authors.initials: A
authors.lastname: Algra
authors.forename: G J E
authors.initials: GJ
authors.lastname: Rinkel
authors.forename: C J
authors.initials: CJ
authors.lastname: Kalkman
mesh_terms: D000758:Anesthesia / Q000009:adverse effects / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects; D001279:Atracurium / Q000008:administration & dosage / Q000009:adverse effects; D015331:Cohort Studies; D005045:Etomidate / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D007022:Hypotension / Q000175:diagnosis*; D002532:Intracranial Aneurysm / Q000601:surgery*; D007431:Intraoperative Complications / Q000175:diagnosis; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000009:adverse effects; D016017:Odds Ratio; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013345:Subarachnoid Hemorrhage / Q000601:surgery*; D017409:Sufentanil / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium; D008012:Lidocaine; D017409:Sufentanil; D015742:Propofol; D005045:Etomidate