Synthesis and radioprotective activity of new organosilicon and germanium compounds.
Silathiazolidine and metalladithioacetals (M = Si, Ge) have been prepared by the interaction of dialkyldichloro- or bis(diethylamino)dialkylsilanes and -germanes with 3-[N-(2- thioethyl)]amino-propanamide (WR-2529) and [1-thioethyl-2-(1-naphtylmethyl)]-2- imidazoline. The study of these compounds in the field of chemical radioprotection has shown a notable decrease in the toxicity and a rather large increase in the radioprotective activity of these new derivatives in comparison with the starting organic compounds.
Rima
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G
Laboratoire d′Hétérochimie Fondamentale et Appliquée UPRES-A 5069 du CNRS Université Paul Sabatier, 118 route de Narbonne Toulouse Cedex 31062 France.
Satgé
J
J
Dagiral
R
R
Lion
C
C
Fatome
M
M
Roman
V
V
Laval
J D
JD