Chlamydia trachomatis Infection, Immunity, and Pregnancy Outcome.
Chlamydia trachomatis can ascend from the cervix to the fallopian tubes and survive for long periods of time without causing symptoms. The immune response to infection clears the extracellular organisms but leads to development of a persistent intracellular infection. Repeated cycles of productive infection and persistence eventually induce tubal occlusion and infertility. Persistently infected cells continue to synthesize the chlamydial 60 kD heat shock protein (hsp60). Immunity to conserved regions of hsp60 may result in autoimmunity to human hsp60. Expression of hsp60 by the embryo and decidua during early pregnancy may reactivate hsp60-sensitized lymphocytes, disturb pregnancy-induced immune regulatory mechanisms, and lead to immune rejection of the embryo. Due to this mechanism women with tubal infertility who are sensitized to the human hsp60 may have a decreased probability of successful outcome after undergoing in vitro fertilization and embryo transfer.
Witkin
S S
SS
Department of Obstetrics and Gynecology Cornell University Medical College 515 East 71st Street New York NY 10021 USA.
Neuer
A
A
Giraldo
P
P
Jeremias
J
J
Tolbert
V
V
Korneeva
I L
IL
Kneissl
D
D
Bongiovanni
A M
AM