title: Background pathology of the ovary in a laboratory population of zebrafish Danio rerio.
abstract: Adult zebrafish Danio rerio originating from one stock used as control animals in a toxicological study were examined histopathologically for the occurrence of spontaneous lesions in the gonads. While no histopathological changes were seen in the testes, the ovaries showed lesions consisting mainly of acute granulomatous inflammation with increased atresia and the presence of egg debris in the ovarian parenchyma and in the oviduct. Since infectious agents could not be detected and the fish were not exposed to toxicants, we consider these lesions as spontaneous alterations of the ovaries.
authors.affiliation: Centre for Fish and Wildlife Health, University of Bern, PO Box 8466, 3001 Bern, Switzerland.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Rossteuscher
authors.forename: Heike
authors.initials: H
authors.lastname: Schmidt-Posthaus
authors.forename: Christoph
authors.initials: C
authors.lastname: Schäfers
authors.forename: Matthias
authors.initials: M
authors.lastname: Teigeler
authors.forename: Helmut
authors.initials: H
authors.lastname: Segner
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D005260:Female; D005393:Fish Diseases / Q000473:pathology*; D008297:Male; D010049:Ovarian Diseases / Q000473:pathology / Q000662:veterinary*; D010053:Ovary / Q000473:pathology*; D015027:Zebrafish