Viral loads of cerebrospinal fluid in infants with enterovirus meningitis.
For a better understanding of the role of the viral load, free radicals, and cytokines in viral meningitis, we surveyed cerebrospinal fluid (CSF) obtained from patients below 1 year of age who showed positive for enterovirus. In their first examinations interleukin (IL)-6 and free radicals increased whereas pleocytosis was rarely observed. IL-6 decreased within the short period. Viral loads and free radicals increased simultaneously. IL-6 and free radicals of CSF are helpful for diagnosis and treatment of viral meningitis at an early stage.
Kawashima
Hisashi
H
Department of Paediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan. hisashi@tokyo-med.ac.jp
Ioi
Hiroaki
H
Ishii
Chiako
C
Hasegawa
Yuka
Y
Amaha
Masahiro
M
Kashiwagi
Yasuyo
Y
Takekuma
Kouji
K
Hoshika
Akinori
A
Watanabe
Yasuo
Y
D004770:Enterovirus / Q000502:physiology; D004769:Enterovirus Infections / Q000134:cerebrospinal fluid* / Q000139:chemically induced / Q000821:virology; D005260:Female; D005609:Free Radicals / Q000134:cerebrospinal fluid; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D007223:Infant; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000134:cerebrospinal fluid; D008297:Male; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000821:virology; D012367:RNA, Viral / Q000134:cerebrospinal fluid; D016896:Treatment Outcome; D019562:Viral Load
D005609:Free Radicals; D016756:Immunoglobulins, Intravenous; D015850:Interleukin-6; D012367:RNA, Viral