A mild, one-pot synthesis of 4-quinolones via sequential Pd-catalyzed amidation and base-promoted cyclization.
A mild, one-pot synthesis of 4-quinolones is described. Under the optimal conditions, a variety of 2-substituted 4-quinolones were synthesized via sequential palladium-catalyzed amidation of 2'-bromoacetophenones followed by base-promoted intramolecular cyclization.
Huang
Jinkun
J
Chemical Process R&D, Amgen Inc, Thousand Oaks, CA 91320, USA. jhuang@amgen.com
Chen
Ying
Y
King
Anthony O
AO
Dilmeghani
Mina
M
Larsen
Robert D
RD
Faul
Margaret M
MM
D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry
D015363:Quinolones; D010165:Palladium