Sleep rebound attenuates context-dependent behavioural sensitization induced by amphetamine.
We have recently demonstrated that paradoxical sleep deprivation (PSD) potentiates the induction of amphetamine (AMPH)-induced behavioural sensitization by increasing its conditioned component. In the present study, the effects of sleep rebound (induced by 24 h recovery period from PSD) were studied on AMPH-induced behavioural sensitization. Sleep rebound attenuated the acute locomotor-stimulating effect of AMPH. AMPH-induced behavioural sensitization was context-specific and was also attenuated by sleep rebound. These results strengthen the notion that sleep conditions can influence AMPH-induced behavioural sensitization.
Calzavara
Mariana Bendlin
MB
Department of Pharmacology, Universidade Federal de São Paulo, Rua Botucatu, 862, Edifício Leal Prado, CEP 04023-062 São Paulo, SP, Brazil.
Andersen
Monica Levy
ML
Fukushiro
Daniela Fukue
DF
Lopez
Giorgia Batlle
GB
Abílio
Vanessa Costhek
VC
Tufik
Sergio
S
Frussa-Filho
Roberto
R
D000661:Amphetamine / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects*; D008124:Locomotion / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects* / Q000502:physiology
D000697:Central Nervous System Stimulants; D000661:Amphetamine