title: Inflammatory response of different chicken lines and B haplotypes to infection with infectious bursal disease virus.
abstract: Chickens representing two different inbred lines (layer and meat-type) and three different B haplotypes (BW1, B19 and B131) were infected with infectious bursal disease virus (IBDV) at 21 days of age. Mortality was recorded, and surviving chickens were killed and examined either 3 or 17 days post-infection. Non-infected control chickens were run in parallel. The variables recorded were all significantly changed by the virus infection, including the serum concentration of mannan-binding lectin that was increased 2-fold 3 days post-infection. A significantly increased mortality, liver to body weight ratio and erythrocyte sedimentation rate (ESR) was seen among chickens from the layer type line compared with the meat-type line. In addition, the haplotype of the chickens influenced the atrophy and hypertrophy of the thymus. It was concluded that the meat-type chicken line was more resistant to IBDV infection than the layer-type line, and that mortality rate, liver to body weight ratio and ESR were valuable variables for evaluation of the level of IBDV infection-induced inflammation and disease.
authors.affiliation: Danish Veterinary Laboratory, Aarhus N, Denmark.
authors.forename: O L
authors.initials: OL
authors.lastname: Nielsen
authors.forename: P
authors.initials: P
authors.lastname: Sørensen
authors.forename: J E
authors.initials: JE
authors.lastname: Hedemand
authors.forename: S B
authors.initials: SB
authors.lastname: Laursen
authors.forename: P H
authors.initials: PH
authors.lastname: Jørgensen