The role of Cdc14 phosphatases in the control of cell division.
The periodicity of CDKs (cyclin-dependent kinases) regulates most cell cycle transitions including cytokinesis. High Cdk1 activity promotes cytoskeletal rearrangements necessary for cell division while at the same time ensuring that cytokinesis does not begin before the separation of sister chromatids during anaphase. The conserved Cdc14 (cell division cycle 14)-family of phosphatases reverses Cdk phosphorylation events and therefore Cdc14 phosphatases promote the process of cytokinesis. Here, we review the elucidated roles of Cdc14 phosphatases in cytokinesis and the current outstanding questions regarding their function in this process.
Clifford
Dawn M
DM
HHMI and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Chen
Chun-Ti
CT
Roberts
Rachel H
RH
Feoktistova
Anna
A
Wolfe
Benjamin A
BA
Chen
Jun-Song
JS
McCollum
Dannel
D
Gould
Kathleen L
KL
D000818:Animals; D002455:Cell Division; D006801:Humans; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D021381:Protein Transport; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000201:enzymology; D012568:Schizosaccharomyces / Q000166:cytology / Q000201:enzymology; D015398:Signal Transduction
D010749:Phosphoprotein Phosphatases