An association between invasive breast cancer and familial idiopathic hyperparathyroidism: a case series and review of the literature.
The possibility of an association between primary hyperparathyroidism and breast cancer has been postulated. We report here a sibship with three premenopausal breast cancers and hyperparathyroidism, and no detectable BRCA or MEN1 gene mutations. We explore genetic and molecular rationales for an association between these metabolic and neoplastic processes.
Pal
Sumanta Kumar
SK
Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Blazer
Kathleen
K
Weitzel
Jeffrey
J
Somlo
George
G
D000328:Adult; D001943:Breast Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D005192:Family Health; D005260:Female; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000235:genetics; D009154:Mutation; D009361:Neoplasm Invasiveness; D010375:Pedigree; D011518:Proto-Oncogene Proteins / Q000235:genetics
C105373:MEN1 protein, human; D011518:Proto-Oncogene Proteins