title: [Gonadotrophin dose and ovarian response: relations to the clinical outcome of in vitro fertilization and embryo transfer].
abstract: OBJECTIVE
  To investigate the association of gonadotrophin (Gn) dose and ovarian response with the clinical outcome of in vitro fertilization and embryo transfer (IVF-ET).
  
  
  METHODS
  Patients undergoing IVF-ET with Gn stimulation for no more than 15 days were enrolled in this study. The patients were divided into 3 groups, namely group A (390 cycles) with total Gn dose :3375 IU and retrieved oocytes:4, group B (64 cycles) with total Gn dose :3375 IU and retrieved oocytes < or =3, and group C (97 cycles) with total Gn dose< or =3300 IU and retrieved oocytes< or =3. The clinical characteristics and outcomes of these 3 groups were comparatively analyzed.
  
  
  RESULTS
  The clinical pregnancy rate and delivery rate were 38.8% and 32.5% in group A, 16.7% and 10.4% in group B, and 27.3% and 23.4% in group C, respectively. The follicle number, oocyte number, number of embryo transferred, peak serum E2 level, clinical pregnancy rate and delivery rate were significantly higher in group A than in groups B and C (P<0.05). Groups B and C had similar follicle number, oocyte number, and number of available embryos, but group C had significantly lower total Gn dose (P<0.05); the peak serum E2 level, clinical pregnancy rate and delivery rate were lower in group B than in group C, but the difference was not statistically significant (P>0.05).
  
  
  CONCLUSIONS
  In patients receiving a relatively low dose of Gn with smaller number of retrieved oocytes, Gn dose increment can improve the clinical pregnancy rate and delivery rate, suggesting a state of relatively poor ovarian response or mild ovarian reserve decrease; failure of increasing the number of oocytes retrieved with greater Gn dose suggests severely decreased ovarian responsiveness or ovarian reserve and also poor clinical prognosis.
authors.affiliation: Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. xiongxiasi@sohu.com
authors.forename: Xia-si
authors.initials: XS
authors.lastname: Xiong
authors.forename: Shi-ling
authors.initials: SL
authors.lastname: Chen
authors.forename: Ling
authors.initials: L
authors.lastname: Sun
authors.forename: Min-na
authors.initials: MN
authors.lastname: Yin
authors.forename: Er-yong
authors.initials: EY
authors.lastname: Zhao
authors.forename: Juan
authors.initials: J
authors.lastname: Song
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006062:Gonadotropins / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology / Q000628:therapy; D006080:Ovarian Follicle / Q000187:drug effects* / Q000503:physiopathology; D010053:Ovary / Q000187:drug effects / Q000503:physiopathology; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D006062:Gonadotropins