title: Clinical role of recurrently elevated macro creatine kinase type 1.
abstract: The typical creatine kinase (CK) isoenzymes include CK-BB, CK-MB, and CK-MM. Macro CK type 1, one of the atypical CK enzymes, has been identified in human serum, but the clinical significance still remains uncertain. In our laboratory, 105 patients who expressed serum macro CK isoenzyme type 1 were identified from March 2004 to March 2007. We found that macro CK type 1 recurred after at least one month in 16 patients. Clinical diagnoses were myopathy in 14 patients, sepsis in one, and acute coronary syndrome in one. The averages of serum total CK and macro CK type 1 were 9,132 and 1,925 (U/L), respectively. The linear regression analysis between recurrent macro CK type 1 and total CK revealed a good correlation (y=3.5054x+2381.3, R(2)=0.7822, P<0.001). Three patients had critical illness, including one respiratory failure and two mortalities. Good linear correlation is documented between total CK and recurrent macro CK type 1. In conclusion, the macro CK type I isoenzyme recurred primarily in patients with myopathy.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan.
authors.forename: Ju-Feng
authors.initials: JF
authors.lastname: Hsiao
authors.forename: Hsiao-Chen
authors.initials: HC
authors.lastname: Ning
authors.forename: Po-Wen
authors.initials: PW
authors.lastname: Gu
authors.forename: Wei-Yee
authors.initials: WY
authors.lastname: Lin
authors.forename: Pao-Hsien
authors.initials: PH
authors.lastname: Chu
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000201:enzymology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007527:Isoenzymes; D046911:Macromolecular Substances; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000175:diagnosis / Q000201:enzymology*; D018805:Sepsis / Q000175:diagnosis / Q000201:enzymology*
chemical_list: D007527:Isoenzymes; D046911:Macromolecular Substances; D003402:Creatine Kinase