Enteric autoantibodies and gut motility disorders.
Increasing evidence suggests that a subset of gastrointestinal motility disorders is associated with the presence of circulating antibodies. These antibodies are directed against various molecular targets, the best known being anti-neuronal nuclear antibody (ANNA-1 or anti-Hu) associated with paraneoplastic motility disorders. There is also evidence that the presence of distinct autoantibody profiles is associated with non-paraneoplastic motility disorders. This review focuses on the types of antibodies associated with gastrointestinal motility disorders and the significance of these antibodies. Algorithms are suggested for the work-up and treatment of patients with circulating antibodies associated with gastrointestinal motility disorders.
Kashyap
Purna
P
Mayo Clinic, Rochester, MN 55905, USA.
Farrugia
Gianrico
G
D001323:Autoantibodies / Q000276:immunology / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000276:immunology*
D001323:Autoantibodies