title: Outbreak of cutaneous leishmaniasis in Silti woreda, Ethiopia: risk factor assessment and causative agent identification.
abstract: An outbreak of skin lesions was reported in June 2005 in the district of Silti woreda, 150 km south of Addis Ababa, by the Christian Children's Fund (CCF) and confirmed to be cutaneous leishmaniasis (CL) by our group from the Armauer Hansen Research Institute in July 2005. A house-to-house survey of 1907 residents in three kebeles of Silti woreda conducted in April 2006 showed a prevalence of 4.8%. RFLP analysis of the internal transcribed spacer RNA (ITS1) showed that Leishmania aethiopica was the causative agent. In the survey, it was found that the age group 11-20 years was the most affected. Environmental factors such as proximity of the house to the gorge where hyraxes reside, presence of the plants Adhatoda schimperiana and Acacia spp. in the compound and sharing the same room with domestic animals were significantly associated with developing CL. The prevalence of active disease was higher in Kibet town (10.4%) compared to the rural kebeles. The identified risk factors of CL in the area need further study. The appearance of leishmaniasis in Silti, which was not known to be endemic for the disease, underlines the need to initiate a leishmaniasis control program in Ethiopia to limit its expansion.
authors.affiliation: Armauer Hansen Research Institute, P.O. Box 1005, Addis Ababa, Ethiopia.
authors.forename: Edessa
authors.initials: E
authors.lastname: Negera
authors.forename: Endalamaw
authors.initials: E
authors.lastname: Gadisa
authors.forename: Lawrence
authors.initials: L
authors.lastname: Yamuah
authors.forename: Howard
authors.initials: H
authors.lastname: Engers
authors.forename: Jemal
authors.initials: J
authors.lastname: Hussein
authors.forename: Teklu
authors.initials: T
authors.lastname: Kuru
authors.forename: Asrat
authors.initials: A
authors.lastname: Hailu
authors.forename: Lashitew
authors.initials: L
authors.lastname: Gedamu
authors.forename: Abraham
authors.initials: A
authors.lastname: Aseffa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005002:Ethiopia / Q000453:epidemiology; D005260:Female; D006801:Humans; D007891:Leishmania / Q000145:classification / Q000302:isolation & purification; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors