title: Delayed adverse vascular events after splenectomy in hereditary spherocytosis.
abstract: BACKGROUND
  It is probable that the variety and frequency of delayed adverse vascular events after splenectomy are underappreciated. Splenectomy is performed for a wide variety of conditions, and delayed postsplenectomy hazards are not often studied.
  
  
  OBJECTIVE
  To estimate the relative risk of adverse vascular events in members of hereditary spherocytosis families who have or have not had a splenectomy.
  
  
  METHODS
  Members of families in which hereditary spherocytosis exists were systematically questioned about adverse vascular events.
  
  
  RESULTS
  The cumulative incidence of arterial and venous events at age 70 years was greater in persons who had undergone a splenectomy for spherocytosis (arterial, 22% females, 32% males; venous, 20% females, 19% males) than in affected persons who did not undergo splenectomy (arterial, 3% females, 2% males; venous, 6% females, 4% males) or non-affected family members (arterial, 10% females, 17% males; venous, 4% females, 12% males). Affected subjects who undergo splenectomy are at greatly increased risk of arterial events as compared to affected subjects who do not undergo splenectomy [arterial, hazard ratio (HR) 7.2, 95% confidence interval (CI) 2.8-17.2; venous, HR 3.3, 95% CI 1.1-9.8].
  
  
  CONCLUSIONS
  There is a significant, long-lasting, increased risk of adverse arterial and venous thromboembolic events after splenectomy performed for hereditary spherocytosis. A review of the literature indicates that this is also true when splenectomy is performed for several other indications.
authors.affiliation: Department of Medicine, Emeritus, University of Wisconsin-Madison, Madison, WI, USA. rfsmd@medicine.wisc.edu
authors.forename: R F
authors.initials: RF
authors.lastname: Schilling
authors.forename: R E
authors.initials: RE
authors.lastname: Gangnon
authors.forename: M I
authors.initials: MI
authors.lastname: Traver
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology*; D011317:Priapism / Q000209:etiology; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000209:etiology; D012307:Risk Factors; D013103:Spherocytosis, Hereditary / Q000150:complications* / Q000601:surgery*; D013156:Splenectomy / Q000009:adverse effects*; D013997:Time Factors; D014652:Vascular Diseases / Q000209:etiology*; D054556:Venous Thromboembolism / Q000209:etiology