title: Relationship between albuminuria, low eGFR, and carotid atherosclerosis in Japanese women.
abstract: In this cross-sectional study, we have investigated whether chronic kidney disease components were associated with carotid plaque and carotid intima-media thickening in women. Between April 2005 and May 2006, 830 women underwent general health screening including carotid ultrasonography and urinary albumin excretion, and were enrolled in the study. Of these individuals examined, 83 (10%) had albuminuria, 203 (24%) had low estimated GFR (eGFR), and 24 (3%) had both albuminuria and low eGFR. Univariate analysis showed that albuminuria, but not low eGFR, was associated with carotid plaque, and that both albuminuria and low eGFR were positively associated with carotid intima-media thickening. Age-adjusted logistic regression analysis showed that albuminuria was positively associated with carotid plaque with an odds ratio of 2.48 (95% CI 1.49-4.11, p < 0.001). On the other hand, association between albuminuria and carotid intima-media thickening was not statistically significant after age adjustment. Positive association between albuminuria and carotid plaque was present when either hypertension or high fasting glucose was absent. In conclusion, in Japanese women who underwent general health screening, albuminuria, but not low eGFR, was positively associated with carotid plaque.
authors.affiliation: Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, Japan. nobuishizka-tky@umin.ac.jp
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ishizaka
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Ishizaka
authors.forename: Mizuki
authors.initials: M
authors.lastname: Tani
authors.forename: Akiko
authors.initials: A
authors.lastname: Toda
authors.forename: Ei-ichi
authors.initials: E
authors.lastname: Toda
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Koike
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamakado
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000209:etiology*; D002340:Carotid Artery Diseases / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000453:epidemiology; D008875:Middle Aged