title: Assessment of medications in patients with tako-tsubo cardiomyopathy.
abstract: BACKGROUND
  Tako-tsubo cardiomyopathy has been gradually recognized worldwide. However, medications for the prevention remain not to be investigated in part because the precise mechanism is unclear. We sought to examine medications before the onset of tako-tsubo cardiomyopathy, and to prove the limitation of these medications for the prevention.
  
  
  RESULTS
  This study consisted of 21 patients with tako-tsubo cardiomyopathy who received one or more medications for hypertension or suspected angina pectoris. Each patient was assessed with history, medications, coronary angiography and left ventriculography. All patients but 1 were female, and age ranged 41 to 87 years (73+/-11 years). Twelve patients received calcium channel blockers, 7 patients received nitrates, and one patient received beta blocker. Three patients received angiotensin coverting enzyme inhibitors, and 4 patients received angiotensin II receptor blockers. One patient died of serious pneumonia, but there was no patient who died of tako-tsubo cardiomyopathy itself. During the 3 year follow-up, one patient receiving angiotensin receptor blocker had the recurrence of tako-tsubo cardiomyopathy due to recurrent epileptic seizure.
  
  
  CONCLUSIONS
  Tako-tsubo cardiomyopathy can occur despite treatment with calcium channel blockers, nitrates or beta-blockers, suggesting limitation of these medications to prevent tako-tsubo cardiomyopathy.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kurisu
authors.forename: Ichiro
authors.initials: I
authors.lastname: Inoue
authors.forename: Takuji
authors.initials: T
authors.lastname: Kawagoe
authors.forename: Masaharu
authors.initials: M
authors.lastname: Ishihara
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shimatani
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Nakama
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Maruhashi
authors.forename: Eisuke
authors.initials: E
authors.lastname: Kagawa
authors.forename: Kazuoki
authors.initials: K
authors.lastname: Dai
authors.forename: Junichi
authors.initials: J
authors.lastname: Matsushita
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Aokage
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ikenaga
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control; D002317:Cardiovascular Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D004364:Pharmaceutical Preparations; D054549:Takotsubo Cardiomyopathy / Q000188:drug therapy* / Q000209:etiology* / Q000517:prevention & control
chemical_list: D002317:Cardiovascular Agents; D004364:Pharmaceutical Preparations