Catalytic enantioselective Reformatsky reaction with ketones.
Chiral tertiary alcohols were obtained with good yields and enantioselectivities via a catalytic Reformatsky reaction with ketones, including the challenging diaryl ketones, using chiral BINOL derivatives.
Fernández-Ibáñez
M Angeles
MA
Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Maciá
Beatriz
B
Minnaard
Adriaan J
AJ
Feringa
Ben L
BL
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007461:Iodoacetates / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D013237:Stereoisomerism
D000438:Alcohols; C406944:BINOL, naphthol; D007461:Iodoacetates; D007659:Ketones; D009284:Naphthols; D009942:Organometallic Compounds; C511262:dimethylzinc; D010100:Oxygen