Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration.
The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.
Jørgensen
Anna Cecilia
AC
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark. acj@farma.ku.dk
Torstenson
Anette Seo
AS
D002152:Calorimetry, Differential Scanning; D003975:Diazepam / Q000008:administration & dosage / Q000737:chemistry*; D004356:Drug Storage; D006813:Humidity; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000737:chemistry*; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D012995:Solubility; D019265:Spectroscopy, Near-Infrared; D013818:Thermogravimetry; D014867:Water / Q000032:analysis; D014961:X-Ray Diffraction
D006993:Hypnotics and Sedatives; D014867:Water; D003975:Diazepam