[Endothelioprotective properties of L-arginine in a nitric oxide deficiency model].
In laboratory animals with endothelial dysfunction (nitric oxide deficiency) modeled by the introduction of NO-synthase inhibitor L-NAME, the activation of endothelioprotective effects of enalapril, lozartan, amlodipine, indapamide and nebivolol is revealed for their introduction in combination with L-arginine. This result was confirmed by the behavior of a generalizing parameter, the coefficient of endothelial dysfunction (CED) calculated using the results of tests on endothelium-dependent and -independent vasodilation.
Pokrovskiĭ
M V
MV
Pokrovskaia
T G
TG
Kochkarov
V I
VI
Artiushkova
E B
EB
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001120:Arginine / Q000494:pharmacology*; D001578:Benzopyrans / Q000494:pharmacology; D004656:Enalapril / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D004983:Ethanolamines / Q000494:pharmacology; D007190:Indapamide / Q000494:pharmacology; D019808:Losartan / Q000494:pharmacology; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D000068577:Nebivolol; D009569:Nitric Oxide / Q000172:deficiency / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D052250:Nitric Oxide Synthase Type III / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology
D000959:Antihypertensive Agents; D001578:Benzopyrans; D004983:Ethanolamines; D020030:Nitric Oxide Donors; D014665:Vasodilator Agents; D000068577:Nebivolol; D009569:Nitric Oxide; D004656:Enalapril; D001120:Arginine; D052250:Nitric Oxide Synthase Type III; D007190:Indapamide; D019808:Losartan; D019331:NG-Nitroarginine Methyl Ester