[Establishment of a rat model of diabetic erectile dysfunction].
OBJECTIVE
To establish a rat model of diabetic erectile dysfunction (ED) with streptozotocin (STZ) injection.


METHODS
Thirty male rats were randomized equally into 5 groups (control group and STZ 40 mg/kg, 60 mg/kg, 80 mg/kg, and 100 mg/kg groups). All the rats were examined at 4 days and 1, 2, and 3 weeks after STZ injection for fasting blood glucose, erectile frequency induced by apomorpHine (APO) and body weight changes.


RESULTS
Significant difference occurred in the fasting food glucose among the groups at different time points (P=0.001), and also in APO-induced erectile frequency, fasting blood glucose and body weight between the groups with STZ injection at different doses (P<0.001, P=0.045 and P<0.001, respectively). No significant difference was found in induced erectile frequency and body weight between different time points (P=0.306 and P=0.628).


CONCLUSIONS
The optimal dose of STZ for establishing diabetic ED model is 60 mg/kg, and two weeks after the injection can be the optimal time for evaluating model establishment by means of APO-induced penis erection.
Cheng
Yi
Y
Huiqiao Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. chengyipla@sina.com
Wei
An-yang
AY
Li
Yu-gang
YG
D000818:Animals; D001058:Apomorphine; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000150:complications*; D004195:Disease Models, Animal; D007172:Erectile Dysfunction / Q000209:etiology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin
D013311:Streptozocin; D001058:Apomorphine