title: A-kinase anchoring proteins as the basis for cAMP signaling.
abstract: Common challenges to any cell are the processing of the extracellular stimuli it receives into intracellular signaling cascades that initiate a multitude of diverse biological functions. However, many of these stimuli act via a common signaling pathway, suggesting the cell must somehow discriminate between different stimuli and respond accordingly. Subcellular targeting through the association with adaptor and scaffolding proteins has emerged as a key mechanism by which cells maintain signaling specificity. Compartmentation of cAMP signaling is maintained by the clustering of cAMP signaling enzymes in discrete units by the scaffolding protein A-kinase anchoring proteins (AKAP). In doing so, AKAPs provide the molecular architecture for the cAMP micordomains that underlie the spacial-temporal control of cAMP signaling.
authors.affiliation: Pat and Jim Calhoun Center for Cardiology, Department of Cell Biology, University of Connecticut Health Center, Farminton, CT 06030, USA. dodge@uchc.edu
authors.forename: K L
authors.initials: KL
authors.lastname: Dodge-Kafka
authors.forename: A
authors.initials: A
authors.lastname: Bauman
authors.forename: M S
authors.initials: MS
authors.lastname: Kapiloff
mesh_terms: D054758:A Kinase Anchor Proteins / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D016503:Drug Delivery Systems; D006801:Humans; D015398:Signal Transduction / Q000502:physiology
chemical_list: D054758:A Kinase Anchor Proteins; C093173:AKAP6 protein, human; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases