Photo-induced electron emission from 17beta-estradiol and progesterone and possible biological consequences.
It was established for the first time, that the sexual hormones 17beta-estradiol (17betaE2) and progesterone (PRG) are able to emit electrons from their excited single state in water-ethanol mixtures. The yield of the "solvated electrons" (e(s)(-)) depends on the substrate concentration, the ratio of water-alcohol-mixtures and the temperature. The e(s)(-) yield obtained from 17betaE2 is by two orders of magnitude higher than this of PRG. The possible relationship of the resulting hormone transients from 17betaE2 leading via specific metabolites to breast cancer is discussed.
Getoff
Nikola
N
Department of Nutritional Sciences, Section Radiation Biology, The University of Vienna, A-1090 Vienna, Althanstrasse 14, UZAII, Austria.
Hartmann
Johannes
J
Department of Nutritional Sciences, Section Radiation Biology, The University of Vienna, A-1090 Vienna, Althanstrasse 14, UZAII, Austria.
Huber
Johannes C
JC
Department of Gynecology, Medical University, A-1090 Vienna, Währinger Gürtel 18-20, Austria.
Quint
Ruth Maria
RM
Department of Nutritional Sciences, Section Radiation Biology, The University of Vienna, A-1090 Vienna, Althanstrasse 14, UZAII, Austria.
D004583:Electrons; D004958:Estradiol / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D018462:Photobiology; D011374:Progesterone / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D014466:Ultraviolet Rays
D011374:Progesterone; D004958:Estradiol