title: Chemical constituents from the stem bark of Trewia nudiflora L. and their antioxidant activities.
abstract: Three new compounds, namely, (+)-dihydrodehydrodiconiferyl alcohol 4- O- beta-(6''- O-galloyl)-glucopyranoside ( 1), 4,4'- O-dimethylellagic acid 3-(2''- O-acetyl)- alpha-rhamnopyranoside ( 2), and ethyl O- beta-(6'-galloyl)-glucopyranoside ( 3), together with eleven known ones, were isolated from the stem bark of Trewia nudiflora. Their structures were elucidated by means of 1D, 2 D NMR and HR-MS analyses. The antioxidant activities of these compounds were evaluated with the DPPH radical-scavenging assay. Compound 1 showed significant antioxidant activity. In addition, compounds 1, 2 and 3 rescued the H (2)O (2)-induced PC12 cell death at 0.4 microM in the MTT assay.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.
authors.forename: Qian-Jin
authors.initials: QJ
authors.lastname: Kang
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Yang
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Wu
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Ma
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Yue-Mao
authors.initials: YM
authors.lastname: Shen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D001713:Biphenyl Compounds; D019665:Euphorbiaceae / Q000737:chemistry*; D006834:Hydrazines; D006861:Hydrogen Peroxide; D015394:Molecular Structure; D016716:PC12 Cells; D010851:Picrates; D024301:Plant Bark / Q000737:chemistry*; D018547:Plant Stems; D011714:Pyrans / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D006834:Hydrazines; D010851:Picrates; D011714:Pyrans; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl