Further evidence for a susceptibility locus contributing to reading disability on chromosome 15q15-q21.
BACKGROUND
Linkage and association studies in dyslexia suggest that a susceptibility locus exists on chromosome 15q15-q21.


OBJECTIVE
This study aims to evaluate these findings in an independent sample of dyslexia.


METHODS
We performed linkage and association analyses using 82 families with dyslexia and 19 STR markers covering the target region on chromosome 15q.


RESULTS
We observed suggestive evidence for linkage at STR-marker D15S143; this was the strongest implicated marker in the previous linkage studies on dyslexia. At the association level, linkage disequilibrium (LD) was found between dyslexia and markers within a circumscribed genomic region recently implicated in two independent studies on dyslexia.


CONCLUSIONS
Our data and the previous reported findings present convincing evidence for a dyslexia-related gene within the identified linkage and LD region on chromosome 15q. However, at this stage it seems difficult to determine whether the linkage and association findings point to more than one susceptibility loci within this region. A definite answer to this question will require systematic single nucleotide polymorphism-based LD mapping within the implicated region, which should lead to the identification of the true dyslexia susceptibility gene(s).
Schumacher
Johannes
J
Institute of Human Genetics, University of Bonn, Bonn, Germany.
König
Inke R
IR
Schröder
Tatjana
T
Duell
Maike
M
Plume
Ellen
E
Propping
Peter
P
Warnke
Andreas
A
Libertus
Claudia
C
Ziegler
Andreas
A
Müller-Myhsok
Bertram
B
Schulte-Körne
Gerd
G
Nöthen
Markus M
MM
D000293:Adolescent; D000483:Alleles; D002648:Child; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D004410:Dyslexia / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008126:Lod Score; D008297:Male; D010641:Phenotype; D019655:Quantitative Trait, Heritable
D005819:Genetic Markers