Solid-phase total synthesis of cyclic decapeptide phakellistatin 12.
Pakellistatin 12 (1) is a new cancer cell growth inhibitory (P388 ED 50 2.8 microg/mL) cyclodecapeptide that was isolated from a marine sponge Phakellia sp. The first total synthesis of compound 1 is reported here using solid-phase methodology with safety-catch linker strategy. For the sequence of amino acids in the cycle, the peptide product was analyzed with a MALDI TOF/TOF instrument, and the structure of the synthetic product was found to be chemically and spectroscopically identical to the natural substance.
Ali
Liaqat
L
H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
Musharraf
Syed Ghulam
SG
Shaheen
Farzana
F
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D011161:Porifera / Q000737:chemistry
D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C478752:phakellistatin 12