Synthesis of the C1-C23 fragment of Spirastrellolide A.
Synthesis of the C1-C23 fragment in spirastrellolide A is described, featuring a cyclic acetal-tethered RCM for stereoselective constructions of spiroketal, and a 1,3- anti aldol involving methyl ketone enolate and Mukaiyama conditions.
Yang
Jin-Haek
JH
Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, WI 53705-2222, USA.
Liu
Jia
J
Hsung
Richard P
RP
D000818:Animals; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D013141:Spiro Compounds; D013237:Stereoisomerism
D018942:Macrolides; D013141:Spiro Compounds; C475125:spirastrellolide A