title: Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase.
abstract: Selective inhibitors of neuronal nitric oxide synthase (nNOS) were shown to protect brain and may be useful in the treatment of neurodegenerative diseases. In this context, our purpose has been to design and synthesize a new family of derivatives of thiadiazoles as possible inhibitors of nNOS. To achieve it a supervised artificial neural network model has been developed for the prediction of inhibition of Nitric Oxide Synthase using a dataset of 119 nNOS inhibitors. The definition of the molecules was achieved from a not-supervised neural network using a home made program named CODES. Also, thiadiazole-based heterocycles, previously predicted, were prepared as conformationally restricted analogues of a selective nNOS inhibitor, S-ethyl N-phenylisothiourea.
authors.affiliation: Instituto de Química Médica, (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
authors.forename: Tania
authors.initials: T
authors.lastname: Castaño
authors.forename: Arantxa
authors.initials: A
authors.lastname: Encinas
authors.forename: Concepción
authors.initials: C
authors.lastname: Pérez
authors.forename: Ana
authors.initials: A
authors.lastname: Castro
authors.forename: Nuria E
authors.initials: NE
authors.lastname: Campillo
authors.forename: Carmen
authors.initials: C
authors.lastname: Gil
mesh_terms: D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D016571:Neural Networks, Computer; D052248:Nitric Oxide Synthase Type I / Q000037:antagonists & inhibitors*; D011237:Predictive Value of Tests; D021281:Quantitative Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013890:Thiourea / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D007527:Isoenzymes; D013830:Thiadiazoles; C106598:S-ethyl N-(4-(trifluoromethyl)phenyl)isothiourea; D052248:Nitric Oxide Synthase Type I; D013890:Thiourea