Evolution of Brunner gland hamartoma associated with Helicobacter pylori infection.
The pathogenesis of Brunner gland hamartoma of the duodenum is unknown. This case report describes the chronology of the development of Brunner gland hamartoma from Brunner gland hyperplasia over a 12-year interval. The study subject, a 64-year-old man with chronic iron deficiency anemia, underwent serial upper endoscopies during this period. Repeated endoscopies demonstrated the evolution of Brunner gland hyperplasia, as manifest endoscopically by a submucosal mass, to a pedunculated polyp with histologic features of Brunner gland hamartoma. The duodenal polypoid mass was removed by snare polypectomy. The patient also had a chronic Helicobacter pylori infection of the stomach. This report details the time-dependent evolution of Brunner gland hyperplasia to hamartoma in association with chronic gastric H. pylori infection.
Kurella
Ravi R
RR
Division of Gastroenterology, Department of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, OK, USA.
Ancha
Hanumantha R
HR
Hussain
Sanam
S
Lightfoot
Stan A
SA
Harty
Richard
R
D001706:Biopsy; D002011:Brunner Glands / Q000473:pathology*; D018450:Disease Progression; D004378:Duodenal Diseases / Q000473:pathology*; D004382:Duodenitis / Q000473:pathology*; D016145:Endoscopy, Digestive System; D005500:Follow-Up Studies; D006222:Hamartoma / Q000473:pathology*; D016481:Helicobacter Infections / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D007417:Intestinal Polyps / Q000473:pathology; D008297:Male; D008875:Middle Aged