title: HLA-DR2 and white matter lesion distribution in MS.
abstract: Human leukocyte antigen DR2 (HLA-DR2) is a well-established genetic risk factor for multiple sclerosis (MS). However, it is still unknown whether this factor is associated with a specific disease phenotype, and in particular, to a regional distribution of white matter (WM) lesion phenotype on magnetic resonance imaging (MRI). On a voxel-by-voxel basis, we analyzed the T1 and T2 MRI-derived lesion maps of 50 patients with MS in order to determine the possible influence of HLA-DR2 genotype on the lesional MRI pattern at early stages of the disease. HLA-DR2 was present in 15 (30%) patients of our cohort. They displayed similar WM lesion distribution as the subjects without this factor. Thus, lesion distribution in MS seems to be independent of the DR2 genotype.
authors.affiliation: Department of Neurology and Neurosurgery of the Clínica Universitaria de Navarra, Pamplona, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Sepulcre
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Masdeu
authors.forename: Ricardo
authors.initials: R
authors.lastname: Palacios
authors.forename: Joaquín
authors.initials: J
authors.lastname: Goñi
authors.forename: Beatriz
authors.initials: B
authors.lastname: Moreno
authors.forename: Mikel
authors.initials: M
authors.lastname: Tainta
authors.forename: Bartolomé
authors.initials: B
authors.lastname: Bejarano
authors.forename: Pablo
authors.initials: P
authors.lastname: Villoslada
mesh_terms: D000328:Adult; D005260:Female; D005838:Genotype; D015802:HLA-DR2 Antigen / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology*; D010641:Phenotype
chemical_list: D015802:HLA-DR2 Antigen