title: Ophthalmic manifestations, cytology, immunohistochemistry, and molecular analysis of intraocular metastatic T-cell lymphoma: report of a case and review of the literature.
abstract: We report a case of T-cell lymphoma metastatic to the eye, with an accompanying review of the literature. A 78-year-old white male with bilateral vitritis was diagnosed with primary cutaneous peripheral T-cell lymphoma unspecified, via vitreous biopsy. The tumor was found to be clonally related to the prior cutaneous malignancy using cytology, immunophenotyping, and molecular analysis. The vast majority of primary intraocular lymphomas are malignant B-cells, whereas intraocular T-cell lymphomas are uncommon. This case demonstrates the utility of immunophenotyping and molecular analysis with microdissection and polymerase chain reaction, as critical adjunctive studies, in patients presenting with a masquerade syndrome, and later diagnosed with T-cell intraocular lymphomas. Vitreo-retinal without uveal involvement in this case, similar to many ocular metastatic T-cell lymphomas reported in the literature, is particularly intriguing because the uvea, not retina, is the typical ocular tissue involvement in the majority of metastatic B-cell lymphomas.
authors.affiliation: National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Grace A
authors.initials: GA
authors.lastname: Levy-Clarke
authors.forename: David
authors.initials: D
authors.lastname: Greenman
authors.forename: Pamela C
authors.initials: PC
authors.lastname: Sieving
authors.forename: Gordon
authors.initials: G
authors.lastname: Byrnes
authors.forename: Defen
authors.initials: D
authors.lastname: Shen
authors.forename: Robert
authors.initials: R
authors.lastname: Nussenblatt
authors.forename: Chi-Chao
authors.initials: CC
authors.lastname: Chan
mesh_terms: D000368:Aged; D005134:Eye Neoplasms / Q000235:genetics / Q000556:secondary*; D017809:Fatal Outcome; D005451:Fluorescein Angiography; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics / Q000473:pathology*; D008297:Male; D016133:Polymerase Chain Reaction; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*; D014822:Vitreous Body / Q000473:pathology*
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta