title: [Neurological effects by occlusion of the carotid artery and induced hypoxia in newborn rats].
abstract: BACKGROUND
  Hypoxic-ischemic encephalopathy is a cause of disability in the infant population. One of the most used animal models in the hypoxic-ischemic encephalopathy in immature brain is the preparation of Levine applied by Rice in newborn rats and consists of the bond of the left common carotid artery followed by induced hypoxia. The objective of this investigation was to study the neurological effects of the bond of the left common carotid and induced hypoxia in newborn rats.
  
  
  METHODS
  Five control rats, five sham rats and five rats with hypoxic-ischemic lesion by means of the application of Levine's preparation at 7 days of age were used. On day 42, all rats were evaluated by time of grasping, posterior reflex test and analysis of the spontaneous locomotor activity (number of bipedal movements, number of stepped stalls, grooming time).
  
  
  RESULTS
  The lesioned group presented less grasping time, lower number of positive responses to the posterior reflex and lower number of stepped stalls (p = 0.024, 0.002 and 0.0001, respectively). There were no statistically significant differences in grooming time or number of bipedal movements.
  
  
  CONCLUSIONS
  Newborn rats in whom Levine preparation was applied presented clinical alterations that may resemble some of the signs that accompany infantile cerebral palsy (grasp problems, wrong response to postural reflexes and alteration in locomotion).
authors.affiliation: Instituto Nacional e Rehabilitación, Mexico, DF, México. jimenaqf@hotmail.com
authors.forename: Jimena
authors.initials: J
authors.lastname: Quinzaños-Fresnedo
authors.forename: Roberto
authors.initials: R
authors.lastname: Coronado-Zarco
authors.forename: Emilio
authors.initials: E
authors.lastname: Arch-Tirado
authors.forename: Antonio
authors.initials: A
authors.lastname: Verduzco-Mendoza
authors.forename: Griselda
authors.initials: G
authors.lastname: Del Valle-Cabrera
authors.forename: Alfonso
authors.initials: A
authors.lastname: Alfaro-Rodríguez
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D016893:Carotid Stenosis / Q000150:complications*; D002547:Cerebral Palsy / Q000209:etiology*; D002534:Hypoxia, Brain / Q000150:complications*; D051381:Rats; D017208:Rats, Wistar