Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora.
A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown gamma-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.
Fiedler
Hans-Peter
HP
Mikrobiologisches Institut, Universität Tübingen, Tübingen, Germany. hans-peter.fiedler@uni-tuebingen.de
Bruntner
Christina
C
Riedlinger
Julia
J
Bull
Alan T
AT
Knutsen
Gjert
G
Goodfellow
Michael
M
Jones
Amanda
A
Maldonado
Luis
L
Pathom-aree
Wasu
W
Beil
Winfried
W
Schneider
Kathrin
K
Keller
Simone
S
Sussmuth
Roderich D
RD
D039903:Actinobacteria / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D006801:Humans; D008826:Microbial Sensitivity Tests; D009429:Netropsin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; C529559:proximicin A; C529560:proximicin B; C529561:proximicin C; D009429:Netropsin