Monoglycerides from the brown alga Sargassum sagamianum: Isolation, synthesis, and biological activity.
Polyunsaturated fatty acid-derived monoglycerides were characterized from the marine brown alga Sargassum sagamianum, collected from Jeju Island, Korea. A new compound of this structural class was isolated and determined to be 1-octadecatetraenoyl glycerol, by combined spectroscopic methods. Based on the structures and bioactivity of these compounds, a series of monoglycerides were synthesized using glycerol and various fatty acids. Several compounds exhibited moderate to significant inhibition of phospholipase A(2) and cyclooxygenase-2.
Chang
Hyeun Wook
HW
College of Pharmacy, Youngnam University, 214-1, Dae, Gyeongsan, Gyeongsangbuk 712-749, Korea.
Jang
Kyoung Hwa
KH
Lee
Doohyun
D
Kang
Hee Ryong
HR
Kim
Tae-Yoon
TY
Lee
Bong Ho
BH
Choi
Byoung Wook
BW
Kim
Sanghee
S
Shin
Jongheon
J
D051546:Cyclooxygenase 2 / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000737:chemistry; D007723:Korea; D015394:Molecular Structure; D050178:Monoglycerides / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D064801:Phospholipase A2 Inhibitors; D044647:Sargassum / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
C530872:1-(6,9,12,15-octadecatetraenoyl)glycerol; D004791:Enzyme Inhibitors; D005231:Fatty Acids, Unsaturated; D050178:Monoglycerides; D064801:Phospholipase A2 Inhibitors; D051546:Cyclooxygenase 2