title: Low-frequency bilateral hypothalamic stimulation for treatment of drug-resistant aggressiveness in a young man with mental retardation.
abstract: Stereotactic bilateral electrode implantation in the medial portion of the posterior hypothalamus was performed on a 22-year-old male with drug-resistant aggressiveness. To localize the targets during implantation, microrecording was performed, and the clinical and electroencephalographic responses to intraoperative stimulation were monitored. The patient had an improved response to low-frequency stimulation that was sustained 18 months later at a follow-up examination.
authors.affiliation: Functional Neurosurgery Unit, Hospital Universitario La Princesa, Madrid, Spain. vhrequejo@hotmail.com
authors.forename: Virgilio
authors.initials: V
authors.lastname: Hernando
authors.forename: Jesus
authors.initials: J
authors.lastname: Pastor
authors.forename: Manuel
authors.initials: M
authors.lastname: Pedrosa
authors.forename: Esteban
authors.initials: E
authors.lastname: Peña
authors.forename: R G
authors.initials: RG
authors.lastname: Sola
mesh_terms: D000328:Adult; D000374:Aggression / Q000502:physiology* / Q000523:psychology; D046690:Deep Brain Stimulation / Q000379:methods*; D004351:Drug Resistance / Q000502:physiology; D006801:Humans; D007034:Hypothalamus, Posterior / Q000502:physiology*; D008607:Intellectual Disability / Q000150:complications / Q000523:psychology / Q000628:therapy*; D008297:Male