Similar cytokine profiles in response to infection with respiratory syncytial virus type a and type B in the upper respiratory tract in infants.
Human respiratory syncytial virus (RSV) is the leading viral cause of severe respiratory illness in infants and young children worldwide. RSV isolates can be divided into 2 subgroups, type A and type B. Here, we compare for the first time the nasal profiles of 27 immune mediators in response to both viral subtypes in 14 children infected with RSV/A, 8 children infected with RSV/B, 11 children coinfected with RSV/A plus other respiratory viruses, and finally, 27 control children, all <2 years old. Our results evidence that children's infection with both RSV subtypes induces very similar profiles of immune mediators in the upper respiratory tract, characterized by the elevation of Th1 and Th2 cytokines, chemokines and growth factors. Interestingly, no major differences in the profiles of the immune mediators were found between the children infected exclusively with RSV/A and those infected with RSV/A plus other respiratory viruses.
Bermejo-Martin
Jesus F
JF
Laboratorio de Inmunología de Mucosas, IBGM, Universidad de Valladolid, Valladolid, Spain. bermejo@ped.uva.es
Tenorio
Alberto
A
Ortiz de Lejarazu
Raul
R
Eiros
Jose M
JM
Matías
Vanesa
V
Dominguez-Gil
Marta
M
Pino
Maria
M
Alonso
Ana
A
Blanco-Quiros
Alfredo
A
Arranz
Eduardo
E
Ardura
Julio
J
D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009305:Nasopharynx / Q000276:immunology* / Q000821:virology; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology* / Q000821:virology; D018113:Respiratory Syncytial Virus, Human / Q000145:classification / Q000472:pathogenicity*; D012141:Respiratory Tract Infections / Q000276:immunology* / Q000821:virology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D016207:Cytokines