Molecular and neural mediators of leptin action.
The adipose tissue-derived hormone, leptin, acts via its receptor (LepRb) in the brain to regulate energy balance and neuroendocrine function. Parsing the biology of leptin requires understanding LepRb signaling and the roles for specific signaling pathways in neural and physiological leptin action. Since the leptin acts via a broadly distributed network of LepRb-expressing neurons, understanding the function of each of these LepRb neural populations will also be crucial. Here, we review the status of knowledge regarding the molecular mediators of leptin action and the neural substrate via which leptin acts to regulate physiologic processes.
Robertson
Scott A
SA
Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0678, USA.
Leinninger
Gina M
GM
Myers
Martin G
MG
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000166:cytology / Q000502:physiology*; D053614:Janus Kinase 2 / Q000378:metabolism; D020738:Leptin / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D054411:Receptors, Leptin / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D001786:Blood Glucose; D020738:Leptin; D054411:Receptors, Leptin; D053614:Janus Kinase 2