title: Who is more vulnerable to die from ozone air pollution?
abstract: BACKGROUND
  Daily increases in ambient ozone have been associated with increased mortality. However, little is known about which subpopulations are more susceptible to death related to ozone.
  
  
  METHODS
  We conducted a case-only study in 48 US cities to identify subpopulations particularly vulnerable to ozone air pollution. Mortality and ozone data were obtained for the period 1989-2000 (May through September of each year) for 2,729,640 decedents. For each potential effect modifier, we fitted city-specific logistic regression models and pooled the results across all cities. Additionally, we examined differences in susceptibility factors according to several city characteristics using a meta-regression.
  
  
  RESULTS
  For each 10 ppb increase in ozone (average of lags 0 to 2), people aged > or =65 years had a 1.10% (95% confidence interval = 0.44% to 1.77%) additional increase in mortality (compared with younger ages). Other groups that were particularly susceptible were black people (additional 0.53% [0.19% to 0.87%]), women (additional 0.58% [0.18% to 0.98%]), and those with atrial fibrillation (additional 1.66% [0.03% to 3.32%]). Susceptibility factors had a larger effect in cities with lower ozone levels. For instance, the additional increase in ozone-related mortality for the elderly was 1.48% (0.81% to 2.15%) in a city with a mean ozone level of 42 ppb versus 0.45% (-0.27% to 1.19%) in a city with a level of 51 ppb.
  
  
  CONCLUSIONS
  We confirmed the susceptibility of the elderly to die of ambient ozone and identified other vulnerable subpopulations including women, blacks, and those with atrial fibrillation. Differences in vulnerability were particularly marked in cities with lower ozone concentrations.
authors.affiliation: Departments of Environmental Health, and bEpidemiology, Harvard School of Public Health, Boston, MA, USA. mmedina@imim.es
authors.forename: Mercedes
authors.initials: M
authors.lastname: Medina-Ramón
authors.forename: Joel
authors.initials: J
authors.lastname: Schwartz
mesh_terms: D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects* / Q000032:analysis; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000145:classification / Q000401:mortality*; D005260:Female; D006801:Humans; D038801:International Classification of Diseases; D016015:Logistic Models; D008171:Lung Diseases / Q000139:chemically induced* / Q000145:classification / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D010126:Ozone / Q000009:adverse effects* / Q000032:analysis; D016012:Poisson Distribution; D017678:Sex Distribution; D014481:United States; D014504:Urban Health / Q000706:statistics & numerical data*
chemical_list: D000393:Air Pollutants; D010126:Ozone