Myelin proteolipid protein: an effective autoantigen and target of autoimmunity in multiple sclerosis.
Myelin proteolipid protein (PLP) is the most abundant protein in central nervous system (CNS) myelin and plays a major role in maintaining the structural and functional integrity of myelin. Its abundance in, and restriction to, CNS myelin and its post-translational modification by acylation make PLP an effective autoantigen, which can induce experimental autoimmune encephalomyelitis in rodents and non-human primates and which is a target of pathogenic autoimmunity in people with multiple sclerosis, a chronic inflammatory demyelinating CNS disease.
Greer
Judith M
JM
School of Medicine, The University of Queensland, Brisbane, Qld 4072, Australia. j.greer@uq.edu.au
Pender
Michael P
MP
D000818:Animals; D001324:Autoantigens / Q000276:immunology* / Q000378:metabolism; D015551:Autoimmunity; D002490:Central Nervous System / Q000276:immunology* / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D009103:Multiple Sclerosis / Q000209:etiology / Q000276:immunology* / Q000378:metabolism; D018991:Myelin Proteolipid Protein / Q000276:immunology* / Q000378:metabolism
D001324:Autoantigens; D018991:Myelin Proteolipid Protein