title: Multiple protein sequence alignment.
abstract: Multiple sequence alignments are essential in computational analysis of protein sequences and structures, with applications in structure modeling, functional site prediction, phylogenetic analysis and sequence database searching. Constructing accurate multiple alignments for divergent protein sequences remains a difficult computational task, and alignment speed becomes an issue for large sequence datasets. Here, I review methodologies and recent advances in the multiple protein sequence alignment field, with emphasis on the use of additional sequence and structural information to improve alignment quality.
authors.affiliation: Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. jpei@chop.swmed.edu
authors.forename: Jimin
authors.initials: J
authors.lastname: Pei
mesh_terms: D011506:Proteins / Q000737:chemistry*; D016415:Sequence Alignment
chemical_list: D011506:Proteins