Anti-inflammatory and antinociceptive activity of Thymus pubescens extract.
Thymus pubescens is an aromatic and medicinal plant, which has been widely distributed in Iran. The anti-inflammatory and analgesic effects of the T. pubescens aerial parts methanol extract were studied at doses of 50-400 mg/kg i.p. using carrageenan-induced edema, formalin, hot plate and writhing tests. The extract produced a significant decrease in the degree of swelling, 3 h after carrageenan injection and caused graded inhibition of both phases of formalin-induced pain. Moreover, in the hot plate test, it significantly raised the pain threshold. While in the writhing test produced a significant decrease in the number of writhing in comparison with the control group (P<0.001). The results of pharmacological tests performed in the present study suggest that the extract of T. pubescens presents analgesic and anti-inflammatory effects.
Mahmoudi
Mitra
M
Department of Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. mtmhmit@yahoo.com
Morteza-Semnani
Katayoun
K
Mojra
Elham
E
D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy; D005557:Formaldehyde; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D046930:Thymus Plant / Q000737:chemistry*
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D005557:Formaldehyde; D009020:Morphine; D002351:Carrageenan