Cytotoxic diarylheptanoids from the pericarps of walnuts (Juglans regia).
Two new diarylheptanoids, juglanin A (1) and B (2), together with 15 known compounds, were isolated from the extract of the seed husks of walnuts (Juglans regia L.). The structures of 1 and 2 were elucidated by various spectroscopic methods including intensive 2D-NMR techniques, HR-ESI-MS, and X-ray single-crystal diffraction analysis, and the cytotoxic activities of 1, 2, and 10 against human hepatoma (Hep G2) cells was reported.
Liu
Jun-Xi
JX
Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, PR China.
Di
Duo-Long
DL
Wei
Xiao-Ning
XN
Han
Yin
Y
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D036381:Diarylheptanoids / Q000737:chemistry / Q000302:isolation & purification*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D031324:Juglans / Q000737:chemistry*; D008968:Molecular Conformation
D000972:Antineoplastic Agents, Phytogenic; D036381:Diarylheptanoids