Male breast cancer 15 years after allogeneic hematopoietic cell transplantation including total body irradiation for recurrent acute lymphoblastic leukemia.
BACKGROUND
Over the years, the prognosis following treatment of a primary cancer has significantly improved. However, the growing population of these cancer survivors has led to the realization of multiple longterm complications secondary to their treatment. One of the most devastating long-term complications is the development of a second malignancy.


METHODS
We report here the case of a 34-year-old man who developed stage IIB node-positive breast cancer almost 15 years following total body irradiation and allogeneic hematopoietic cell transplantation for acute lymphoblastic leukemia. To our knowledge, this is only the second report of a male breast cancer following allogeneic bone marrow transplantation (BMT).


CONCLUSIONS
Survivors of primary cancer need lifelong monitoring for complications from their initial therapy.
Lowe
Thomas
T
City of Hope Comprehensive Cancer Center, Duarte, CA 91010-3000, USA.
Luu
Thehang
T
Shen
Jeannie
J
Bhatia
Smita
S
Shibata
Stephen
S
Stein
Anthony
A
Somlo
George
G
D000328:Adult; D018567:Breast Neoplasms, Male / Q000175:diagnosis / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009364:Neoplasm Recurrence, Local; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000628:therapy*; D014916:Whole-Body Irradiation / Q000009:adverse effects*