title: The effects of chrysin, a Passiflora incarnata extract, on natural killer cell activity in male Sprague-Dawley rats undergoing abdominal surgery.
abstract: Chrysin, a passion flower extract, may be beneficial because of its potential to attenuate surgical suppression of natural killer (NK) cell activity. We divided 37 male Sprague-Dawley rats into 3 treatment groups: (1) rats undergoing abdominal surgery and administered isoflurane and a 5% solution of dimethyl sulfoxide in saline (vehicle), (2) rats undergoing abdominal surgery and administered isoflurane and chrysin solubilized in 5% dimethyl sulfoxide, and (3) rats not undergoing surgery but administered isoflurane and chrysin. Natural killer cell activity was measured before and 24 hours after the experiment. Analysis of covariance, with preoperative NK cell activity as the covariate, was used to compare differences in NK cell activity among groups. The Scheffe procedure was used to make post hoc comparisons. Analysis revealed a significant difference (P = .006) such that group 2 had significantly less NK cell suppression compared with groups 1 and 3. These findings suggest that chrysin may attenuate surgical suppression of NK cell activity, thereby minimizing metastatic spread of cancer.
authors.affiliation: The Carl R. Darnell Army Medical Center, Fort Hood, Texas, USA. Denise.beaumont@AMEDD.ARMY.MIL
authors.forename: Denise M
authors.initials: DM
authors.lastname: Beaumont
authors.forename: Terrence M
authors.initials: TM
authors.lastname: Mark
authors.forename: Reginald
authors.initials: R
authors.lastname: Hills
authors.forename: Patricia
authors.initials: P
authors.lastname: Dixon
authors.forename: Bruce
authors.initials: B
authors.lastname: Veit
authors.forename: Normalynn
authors.initials: N
authors.lastname: Garrett
mesh_terms: D000280:Administration, Inhalation; D000704:Analysis of Variance; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D000818:Animals; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology; D018755:GABA Agonists / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology; D007108:Immune Tolerance / Q000187:drug effects / Q000502:physiology; D007530:Isoflurane / Q000008:administration & dosage; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D007813:Laparotomy / Q000009:adverse effects*; D018655:Lymphocyte Count; D008297:Male; D029598:Passiflora; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012997:Solvents / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D005419:Flavonoids; D018755:GABA Agonists; D010936:Plant Extracts; D012997:Solvents; C043561:chrysin; D007530:Isoflurane; D004121:Dimethyl Sulfoxide