title: Is p190 bcr-abl rearrangement necessary for acute transformation in some p210 CML of childhood?
abstract: Chronic myeloid leukemia (CML) is a rare disease in childhood which is almost exclusively associated with bcr-abl p210 (M-bcr) rearrangements. It has been suggested that co-expression of p190 and p210 may be a pathway of CML progression in adult patients. We report two cases of pediatric patients with a diagnosis of CML who presented co-expression of the p210 and p190 transcripts during progression to the blastic phase. The present data suggest that p190 may be a secondary event in at least some cases of childhood CML, suggesting an association with progression to a blastic crisis in these patients.
authors.affiliation: Department of Pediatrics, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto (SP), Brazil.
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Scrideli
authors.forename: Fábio Morato
authors.initials: FM
authors.lastname: de Oliveira
authors.forename: Maria Sol
authors.initials: MS
authors.lastname: Brassesco
authors.forename: Rosane
authors.initials: R
authors.lastname: de Paula Queiroz
authors.forename: José Eduardo
authors.initials: JE
authors.lastname: Bernardes
authors.forename: Elvis Terci
authors.initials: ET
authors.lastname: Valera
authors.forename: Luiz Gonzaga
authors.initials: LG
authors.lastname: Tone
mesh_terms: D001752:Blast Crisis; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D012334:RNA, Neoplasm / Q000032:analysis
chemical_list: D012334:RNA, Neoplasm; D016044:Fusion Proteins, bcr-abl