Enhancement of adipogenesis induction by conditioned media obtained from cancer cells.
White adipose tissue is a multifunctional endocrine organ that synthesizes and secretes cytokine-like proteins termed adipokines. In the present study, the effects of cancer-derived medium on adipogenesis were examined. We prepared conditioned media from cancer cell lines, and cultured preadipocytes in the conditioned media. After 10 days of culture, intracellular lipid droplet accumulation was measured. We observed that the conditioned media significantly induced adipogenesis or enhanced the adipogenesis induced by adipogenesis inducers. Although we could not define the factors, these undefined factors derived from cancer cells may induce adipogenesis, and the resulting adipogenesis may affect cancer development.
Hirano
Takeshi
T
Graduate School of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka, Japan. t-hirano@env.kitakyu-u.ac.jp
Morii
Haruki
H
Nakazawa
Koji
K
Murakami
Daisuke
D
Yamashita
Akihisa
A
Asahi
Junpei
J
Orimo
Hiroshi
H
Tamae
Kazuyoshi
K
Tokura
Yoshiki
Y
D050156:Adipogenesis; D002450:Cell Communication; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D017077:Culture Media, Conditioned; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000209:etiology
D017077:Culture Media, Conditioned