title: Sansanmycins B and C, new components of sansanmycins.
abstract: Two new antibiotics, sansanmycins B and C, were isolated from Streptomyces sp. SS. Their structures were elucidated by extensive 1D and 2D NMR and MS spectral analyses. Sansanmycins B and C exhibited inhibitory activity against our test strain of Pseudomonas aeruginosa with MIC values of 8.0 and 16 microg/ml, respectively. Sansanmycin B also exhibited inhibitory activity against Mycobacterium tuberculosis H37Rv and multidrug-resistant Mycobacterium tuberculosis, with the MIC values ranging from 8.0 to 20 microg/ml.
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, China.
authors.forename: Yunying
authors.initials: Y
authors.lastname: Xie
authors.forename: Hongzhang
authors.initials: H
authors.lastname: Xu
authors.forename: Shuyi
authors.initials: S
authors.lastname: Si
authors.forename: Chenghang
authors.initials: C
authors.lastname: Sun
authors.forename: Ruxian
authors.initials: R
authors.lastname: Chen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*; D014529:Uridine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D009842:Oligopeptides; C530708:sansanmycin B; D014529:Uridine