Imaging stem cell implant for cellular-based therapies.
Stem cell-based cellular therapy represents a promising outlook for regenerative medicine. Imaging techniques provide a means for noninvasive, repeated, and quantitative tracking of stem cell implant or transplant. From initial deposition to the survival, migration and differentiation of the transplant/implanted stem cells, imaging allows monitoring of the infused cells in the same live object over time. The current review briefly summarizes and compares existing imaging methods for cell labeling and imaging in animal models. Several studies performed by our group using different imaging techniques are described, with further discussion on the issues with these current imaging approaches and potential directions for future development in stem cell imaging.
Lee
Zhenghong
Z
Department of Radiology, National Center for Regenerative Medicine, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA. Zxl11@case.edu
Dennis
James E
JE
Gerson
Stanton L
SL
D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D002470:Cell Survival; D017930:Genes, Reporter; D006801:Humans; D007205:Indium Radioisotopes; D008163:Luminescent Measurements; D008279:Magnetic Resonance Imaging; D051379:Mice; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology* / Q000000981:diagnostic imaging / Q000502:physiology; D027981:Symporters / Q000235:genetics; D000099209:Sodium-Iodide Symporters
D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D027981:Symporters; D000099209:Sodium-Iodide Symporters