title: A novel antimycin-like compound, JBIR-06, from Streptomyces sp. ML55.
abstract: A novel compound of antimycin family, JBIR-06 (1), was isolated from Streptomyces sp. ML55. The structure of 1 was established as a twelve-membered macrocyclic skeleton with a 3-(formylamino)-2-hydroxybenzamide based on the spectroscopic data. Compound 1 inhibited the expression of GRP78 induced by 2-deoxyglucose at the IC50 value of 250 nM.
authors.affiliation: Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Japan.
authors.forename: Jun-ya
authors.initials: JY
authors.lastname: Ueda
authors.forename: Aya
authors.initials: A
authors.lastname: Nagai
authors.forename: Miho
authors.initials: M
authors.lastname: Izumikawa
authors.forename: Shuhei
authors.initials: S
authors.lastname: Chijiwa
authors.forename: Motoki
authors.initials: M
authors.lastname: Takagi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shin-ya
mesh_terms: D000968:Antimycin A / Q000031:analogs & derivatives / Q000302:isolation & purification; D001549:Benzamides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D003847:Deoxyglucose / Q000494:pharmacology; D000091342:Endoplasmic Reticulum Chaperone BiP; D006360:Heat-Shock Proteins / Q000037:antagonists & inhibitors*; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018832:Molecular Chaperones / Q000037:antagonists & inhibitors*; D008968:Molecular Conformation; D013302:Streptomyces / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D001549:Benzamides; D000091342:Endoplasmic Reticulum Chaperone BiP; C000717247:HSPA5 protein, human; D006360:Heat-Shock Proteins; C530710:JBIR 06; D018942:Macrolides; D018832:Molecular Chaperones; C032456:antimycin; D000968:Antimycin A; D003847:Deoxyglucose