title: The role of Cdc14 phosphatases in the control of cell division.
abstract: The periodicity of CDKs (cyclin-dependent kinases) regulates most cell cycle transitions including cytokinesis. High Cdk1 activity promotes cytoskeletal rearrangements necessary for cell division while at the same time ensuring that cytokinesis does not begin before the separation of sister chromatids during anaphase. The conserved Cdc14 (cell division cycle 14)-family of phosphatases reverses Cdk phosphorylation events and therefore Cdc14 phosphatases promote the process of cytokinesis. Here, we review the elucidated roles of Cdc14 phosphatases in cytokinesis and the current outstanding questions regarding their function in this process.
authors.affiliation: HHMI and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
authors.forename: Dawn M
authors.initials: DM
authors.lastname: Clifford
authors.forename: Chun-Ti
authors.initials: CT
authors.lastname: Chen
authors.forename: Rachel H
authors.initials: RH
authors.lastname: Roberts
authors.forename: Anna
authors.initials: A
authors.lastname: Feoktistova
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Wolfe
authors.forename: Jun-Song
authors.initials: JS
authors.lastname: Chen
authors.forename: Dannel
authors.initials: D
authors.lastname: McCollum
authors.forename: Kathleen L
authors.initials: KL
authors.lastname: Gould
mesh_terms: D000818:Animals; D002455:Cell Division; D006801:Humans; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D021381:Protein Transport; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000201:enzymology; D012568:Schizosaccharomyces / Q000166:cytology / Q000201:enzymology; D015398:Signal Transduction
chemical_list: D010749:Phosphoprotein Phosphatases