The use of Affymetrix GeneChips as a tool for studying alternative forms of RNA.
We are developing a computational pipeline to use surveys of Affymetrix GeneChips as a discovery tool for unravelling some of the biology associated with post-transcriptional processing of RNA. This work involves the integration of a number of bioinformatics resources, from comparing annotations to processing images to determining the structure of transcripts. The rapidly growing datasets of GeneChips available to the community puts us in a strong position to discover novel biology about post-transcriptional processing, and should enable us to determine the mechanisms by which some groups of genes make co-ordinated changes in their production of isoforms.
Harrison
Andrew P
AP
Departments of Biological Sciences and Mathematical Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK. harry@essex.ac.uk
Rowsell
Joanna
J
da Silva Camargo
Renata
R
Langdon
William B
WB
Stalteri
Maria
M
Upton
Graham J G
GJ
Arteaga-Salas
Jose M
JM
D017398:Alternative Splicing / Q000235:genetics; D000818:Animals; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D026723:Polyadenylation; D012313:RNA / Q000378:metabolism*
D012313:RNA