title: Association study of the interleukin-1 gene complex and tumor necrosis factor alpha gene with suicide attempts.
abstract: To investigate the association between four functional polymorphisms in interleukin-1 (IL-1) [IL-1 alpha -889 C/T, IL-1 beta +3953 C/T, IL-1RA (86 bp)n] and tumor necrosis factor alpha (TNFalpha) (-308A/G) genes and suicide attempts. Distribution of the aforesaid polymorphisms was analyzed in 193 suicide attempters compared with 420 unrelated healthy controls from Asturias (Northern Spain). Genotypes were determined using standard methods. No significant differences were found in genotype or in allelic distribution of IL-1 alpha, IL-1 beta, IL-1RA, or TNFalpha gene polymorphisms. No relationship was found between genotypes and the impulsivity of the suicide attempt. Estimated IL-1 haplotype frequencies were similar in both groups (likelihood ratio test=13.26, df=14, P=0.506). Our data do not suggest that genetically determined changes in the IL-1 or TNFalpha genes confer increased susceptibility to suicidal behavior.
authors.affiliation: Department of Psychiatry, School of Medicine, University of Oviedo, Julián Clavería, Oviedo, Spain. frank@uniovi.es
authors.forename: Pilar A
authors.initials: PA
authors.lastname: Sáiz
authors.forename: Paz
authors.initials: P
authors.lastname: García-Portilla
authors.forename: Begoña
authors.initials: B
authors.lastname: Paredes
authors.forename: Celso
authors.initials: C
authors.lastname: Arango
authors.forename: Blanca
authors.initials: B
authors.lastname: Morales
authors.forename: Victoria
authors.initials: V
authors.lastname: Alvarez
authors.forename: Eliécer
authors.initials: E
authors.lastname: Coto
authors.forename: María-Teresa
authors.initials: MT
authors.lastname: Bascarán
authors.forename: Manuel
authors.initials: M
authors.lastname: Bousoño
authors.forename: Julio
authors.initials: J
authors.lastname: Bobes
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D013406:Suicide, Attempted; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha