Increased vasoconstriction predisposes to hyperpnea and postural faint.
Our prior studies indicated that postural fainting relates to splanchnic hypervolemia and thoracic hypovolemia during orthostasis. We hypothesized that thoracic hypovolemia causes excessive sympathetic activation, increased respiratory tidal volume, and fainting involving the pulmonary stretch reflex. We studied 18 patients 13-21 yr old, 11 who fainted within 10 min of upright tilt (fainters) and 7 healthy control subjects. We measured continuous blood pressure and heart rate, respiration by inductance plethysmography, end-tidal carbon dioxide (ET(CO(2))) by capnography, and regional blood flows and blood volumes using impedance plethysmography, and we calculated arterial resistance with patients supine and during 70 degrees upright tilt. Splanchnic resistance decreased until faint in fainters (44 +/- 8 to 21 +/- 2 mmHg.l(-1).min(-1)) but increased in control subjects (47 +/- 5 to 53 +/- 4 mmHg.l(-1).min(-1)). Percent change in splanchnic blood volume increased (7.5 +/- 1.0 vs. 3.0 +/- 11.5%, P < 0.05) after the onset of tilt. Upright tilt initially significantly increased thoracic, pelvic, and leg resistance in fainters, which subsequently decreased until faint. In fainters but not control subjects, normalized tidal volume (1 +/- 0.1 to 2.6 +/- 0.2, P < 0.05) and normalized minute ventilation increased throughout tilt (1 +/- 0.2 to 2.1 +/- 0.5, P < 0.05), whereas respiratory rate decreased (19 +/- 1 to 15 +/- 1 breaths/min, P < 0.05). Maximum tidal volume occurred just before fainting. The increase in minute ventilation was inversely proportionate to the decrease in ET(CO(2)). Our data suggest that excessive splanchnic pooling and thoracic hypovolemia result in increased peripheral resistance and hyperpnea in simple postural faint. Hyperpnea and pulmonary stretch may contribute to the sympathoinhibition that occurs at the time of faint.
Taneja
Indu
I
Department of Pediatrics, New York Medical College, Hawthorne, NY 10532, USA. indu_taneja@nymc.edu
Medow
Marvin S
MS
Glover
June L
JL
Raghunath
Neeraj K
NK
Stewart
Julian M
JM
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D001810:Blood Volume; D019296:Capnography; D002307:Cardiography, Impedance; D016022:Case-Control Studies; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D010388:Pelvis / Q000098:blood supply; D012018:Reflex; D012039:Regional Blood Flow; D015656:Respiratory Mechanics; D013152:Splanchnic Circulation; D016683:Supine Position; D013564:Sympathetic Nervous System / Q000503:physiopathology; D013575:Syncope / Q000503:physiopathology*; D013909:Thorax / Q000098:blood supply*; D013990:Tidal Volume; D013997:Time Factors; D014655:Vascular Resistance; D014661:Vasoconstriction