title: The reduction of arterial tension produced by stevioside is dependent on nitric oxide synthase activity when the endothelium is intact.
abstract: In endothelium-intact rat aortic ring preparations pre-contracted with norepinephrine or KCl, NG-nitro L-arginine (L-NOARG, 0.1 mM) and 1H-[1,2,4] oxidiazolo [4,3-a] quinoxalin-1-one (ODQ, 10 microM) antagonized the reduction of the vascular tone induced by stevioside, but this antagonism did not occur when the experiment was performed with endothelium-denuded aortic rings. The data indicates that the vasodilatation produced by stevioside is dependent on nitric oxide synthase and guanylate cyclase activities when the endothelium is not damaged.
authors.affiliation: Department of Pharmacy and Pharmacology, State University of Maringa, Maringa-PR, Brazil.
authors.forename: Elaine Campana Sanches
authors.initials: EC
authors.lastname: Bornia
authors.forename: Valéria
authors.initials: V
authors.lastname: do Amaral
authors.forename: Roberto Barbosa
authors.initials: RB
authors.lastname: Bazotte
authors.forename: Wilson
authors.initials: W
authors.lastname: Alves-Do-Prado
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic; D045786:Diterpenes, Kaurane / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005960:Glucosides / Q000494:pharmacology*; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors / Q000378:metabolism; D066298:In Vitro Techniques; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D019335:Nitroarginine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010069:Oxadiazoles / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D013549:Sweetening Agents / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*
chemical_list: C095284:1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one; D045786:Diterpenes, Kaurane; D004791:Enzyme Inhibitors; D005960:Glucosides; D010069:Oxadiazoles; D011810:Quinoxalines; D013549:Sweetening Agents; D014662:Vasoconstrictor Agents; C012043:stevioside; D019335:Nitroarginine; D011189:Potassium Chloride; D019001:Nitric Oxide Synthase; D006162:Guanylate Cyclase; D009638:Norepinephrine