title: South Asian chronic lymphocytic leukaemia patients have more rapid disease progression in comparison to White patients.
abstract: Ethnicity has a major impact on the prevalence of chronic lymphocytic leukaemia (CLL) and may also influence disease phenotype. We compared the clinical features of Southern Asian and White CLL patients managed within one UK region. Asians required treatment almost twice as often as Whites (HR, 1.94) and had a shorter time to first treatment (P = 0.0063). This difference remained significant after adjusting for stage, lymphocyte doubling time and IGHV status (P = 0.026). CLL was diagnosed at younger ages in Asians and racial-specific variations in IGHV usage were demonstrated. Our findings indicate that Southern Asian race has a negative impact on CLL phenotype.
authors.affiliation: CRUK Institute for Cancer Studies, University of Birmingham, Birmingham, UK.
authors.forename: Chaminda
authors.initials: C
authors.lastname: Gunawardana
authors.forename: Belinda
authors.initials: B
authors.lastname: Austen
authors.forename: Judith E
authors.initials: JE
authors.lastname: Powell
authors.forename: Christopher
authors.initials: C
authors.lastname: Fegan
authors.forename: Farooq
authors.initials: F
authors.lastname: Wandroo
authors.forename: Abe
authors.initials: A
authors.lastname: Jacobs
authors.forename: Guy
authors.initials: G
authors.lastname: Pratt
authors.forename: Paul
authors.initials: P
authors.lastname: Moss
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001208:Asia / Q000208:ethnology; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D018450:Disease Progression; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000208:ethnology* / Q000401:mortality / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D051997:ADP-ribosyl Cyclase 1