Factor V Leiden mutation is associated with improved 30-day survival in patients with acute respiratory distress syndrome.
OBJECTIVE
Activation of coagulation and inflammation are parts of the innate host response to infection that may contribute to organ dysfunction and death when control of these systems is compromised. Thus, functional single nucleotide polymorphisms within candidate genes of the inflammation and coagulation cascade are possible factors which may influence severity and/or mortality in acute respiratory distress syndrome. The aim of this study was to investigate whether the factor V Leiden mutation (Arg506Gln) is associated with altered severity and/or mortality in acute respiratory distress syndrome.


METHODS
Retrospective cohort, genetic association study.


METHODS
Tertiary care intensive care unit.


METHODS
Adults (white Germans) with acute respiratory distress syndrome (n = 106).


METHODS
Genotyping for the factor V Leiden mutation.


RESULTS
Using Kaplan-Meier estimates to compare outcome, 30-day survival was significantly associated with the factor V Leiden mutation (p = .049). Thirty-day survival rates were 100% for Arg/Gln (n = 7) genotypes but only 58% for Arg/Arg (n = 99) genotypes, respectively.


CONCLUSIONS
We show for the first time that a heterozygous factor V Leiden genotype is associated with improved 30-day survival in patients with acute respiratory distress syndrome.
Adamzik
Michael
M
Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg-Essen, Universitätsklinikum Essen, Essen, Germany. michael.adamzik@uk-essen.de
Frey
Ulrich H
UH
Riemann
Kathrin
K
Sixt
Stephan
S
Lehmann
Nils
N
Siffert
Winfried
W
Peters
Jürgen
J
D018806:APACHE; D020016:Activated Protein C Resistance / Q000235:genetics*; D000328:Adult; D001120:Arginine / Q000235:genetics; D015331:Cohort Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D005838:Genotype; D005973:Glutamine / Q000235:genetics; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D017354:Point Mutation / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012128:Respiratory Distress Syndrome / Q000235:genetics* / Q000401:mortality; D012189:Retrospective Studies
C095381:factor V Leiden; D005973:Glutamine; D005165:Factor V; D001120:Arginine