title: Two new 5-hydroxy-2-pyrone derivatives isolated from a marine-derived fungus Aspergillus flavus.
abstract: Two new compounds, 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (1) and (5-hydroxy-2-oxo-2H-pyran-4-yl) methyl acetate (2), have been isolated from a marine-derived fungus Aspergillus flavus. Their structures were determined by spectroscopic data. Compound 1 induced the production of cAMP on GPR12 transfected CHO and HEK293 cells in a dose-dependent manner, which indicated 1 might be a possible ligand for GPR12.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China.
authors.forename: Aiqun
authors.initials: A
authors.lastname: Lin
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Lu
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Fang
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001231:Aspergillus flavus / Q000378:metabolism*; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization; D014871:Water Microbiology
chemical_list: C097350:GPR12 protein, human; D011753:Pyrones; D043562:Receptors, G-Protein-Coupled