Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha.
Synthesis of IL-1beta and TNFalpha by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC(50) values in the muM range. The results indicate that these compounds may have value in the therapy of human diseases where these inflammatory cytokines have a central role in pathogenesis.
Seow
W K
WK
lmmunobiology Laboratory The University of Queensland Dental School Brisbane 4000 Australia.
Nakamura
K
K
Sugimura
Y
Y
Sugimoto
Y
Y
Yamada
Y
Y
Fairlie
D P
DP
Thong
Y H
YH