A very low dose intravenous dexamethasone suppression test as an index of glucocorticoid sensitivity.
OBJECTIVE
The wide variability of responses to corticotherapy suggests a role for individual recognition of steroid sensitivity in order to customize treatment. Oral dexamethasone (DEX) administration may be hindered by the rate of its intestinal absorption and the liver first-passage effect. In this study we suggest that an intravenous very low dose DEX suppression test (VLD IV-DST) can be used as an index for glucocorticoid (GC) sensitivity.


METHODS
We evaluated 87 normal subjects: 44 prepubertal children, 23 adolescents and 20 adults with a VLD IV-DST using 20 mug/m(2) of DEX (dose able to recognize GC sensitivity). Cortisol was initially measured at several time-points after DEX prompting us to establish its nadir and subsequent simplification of the test by measuring cortisol at baseline and after 120 min.


RESULTS
Baseline cortisol was similar in adolescents and in adults, but lower in children. There was a spectrum of individual responses in all age groups. The percent reduction of cortisol after 120 min was different in these three age groups, with median values of 44.4% in children, 25.9% in adolescents and 61.6% in adults.


CONCLUSIONS
This simplified VLD IV-DST using 20 mug/m(2) of DEX is useful to evaluate individual sensitivity to GC in different age groups.
Faria
Cláudia Dutra Costantin
CD
Pediatric Endocrinology Unit, Pediatric Department, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil.
Cobra
Jayme F
JF
Sousa E Silva
Tatiane
T
Melo
Murilo Rezende
MR
Rocha
Mylene Neves
MN
Hayashi
Lílian Sukusima
LS
Faria
Thelma Gomes
TG
de Souza e Almeida
Julio Antonio
JA
Kater
Cláudio Elias
CE
Longui
Carlos Alberto
CA
D000293:Adolescent; D000328:Adult; D002648:Child; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011965:Receptors, Glucocorticoid / Q000187:drug effects*
D011965:Receptors, Glucocorticoid; D003907:Dexamethasone; D006854:Hydrocortisone