title: Utilization of a uniform grading system for interpreting serous ovarian cancer.
abstract: OBJECTIVE
  The purpose of the study was to implement a uniform system for assigning tumor grade in serous ovarian cancer and evaluate its correlation with response to conventional chemotherapy.
  
  
  METHODS
  Serous ovarian cancer tumor samples were retrospectively reviewed by 3 pathologists who were blinded to the original report. Samples were scored for architectural pattern, nuclear pleomorphism, and mitotic activity. Sum scores from these 3 indices were used to classify tumors as low grade or high grade.
  
  
  RESULTS
  A total of 21 patients were identified as low-grade tumors and 21 were identified as high-grade tumors. Of low-grade tumors, 16 (76%) were found to be platinum resistant, defined as recurrent or persistent disease, 180 days from completion of the final cycle of chemotherapy, Of 21 patients defined as high grade, 9 (43%) were platinum resistant (P = .028).
  
  
  CONCLUSIONS
  Utilization of a uniform grading system retrospectively correlates with platinum sensitivity.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Virginia Health System, Charlottesville, VA 22908, USA. jal5f@virginia.edu
authors.forename: Jason A
authors.initials: JA
authors.lastname: Lachance
authors.forename: Jamie
authors.initials: J
authors.lastname: Shutter
authors.forename: Kristen A
authors.initials: KA
authors.lastname: Atkins
authors.forename: Mark H
authors.initials: MH
authors.lastname: Stoler
authors.forename: Laurel W
authors.initials: LW
authors.lastname: Rice
authors.forename: Amir A
authors.initials: AA
authors.lastname: Jazaeri
mesh_terms: D018284:Cystadenocarcinoma, Serous / Q000473:pathology*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D008940:Mitotic Index; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology*; D010865:Pilot Projects; D011237:Predictive Value of Tests; D012189:Retrospective Studies