Estrogen and MYB in breast cancer: potential for new therapies.
MYB is highly expressed in almost all estrogen receptor (ER)-positive breast tumours and is a direct target of estrogen/ER signalling. Our recent studies have shown that MYB is also required for the proliferation of ER-positive breast tumour cell lines, and have shed further light on the mechanism of ER regulation of MYB expression. Here we discuss the rationale for therapeutic targeting of MYB in breast cancer and consider a number of approaches to developing an anti-MYB therapeutic.
Gonda
Thomas J
TJ
Professorial Research Fellow, Deputy Director and Head Cancer Biology Program, University of Queensland Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia. t.gonda@uq.edu.au
Leo
Paul
P
Ramsay
Robert G
RG
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D002455:Cell Division; D045744:Cell Line, Tumor / Q000378:metabolism / Q000473:pathology; D015195:Drug Design; D004967:Estrogens / Q000502:physiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D020570:Genes, myb; D006801:Humans; D009363:Neoplasm Proteins / Q000032:analysis / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology; D009376:Neoplasms, Hormone-Dependent / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use; D020626:Oncogene Proteins v-myb / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology*; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use; D011485:Protein Binding / Q000187:drug effects; D025941:Protein Interaction Mapping; D034622:RNA Interference; D011960:Receptors, Estrogen / Q000032:analysis / Q000737:chemistry / Q000502:physiology; D014158:Transcription, Genetic / Q000187:drug effects
D000970:Antineoplastic Agents; D004967:Estrogens; D009363:Neoplasm Proteins; D019384:Nucleic Acid Synthesis Inhibitors; D020626:Oncogene Proteins v-myb; D010455:Peptides; D011960:Receptors, Estrogen