title: A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues.
abstract: Cyclic-di-guanylate (c-di-GMP) has emerged as a general and important signaling molecule uniquely present in bacteria: herein we provide a simple solid-phase synthesis of c-di-GMP using an automated DNA synthesizer for the majority of the synthesis.
authors.affiliation: Department of Chemistry and Biochemistry, Building 091, University of Maryland, College Park, MD 20742, USA. hsintim@umd.edu.
authors.forename: Irene
authors.initials: I
authors.lastname: Kiburu
authors.forename: Andrew
authors.initials: A
authors.lastname: Shurer
authors.forename: Lei
authors.initials: L
authors.lastname: Yan
authors.forename: Herman O
authors.initials: HO
authors.lastname: Sintim
mesh_terms: D001419:Bacteria / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D003500:Cyclization; D008968:Molecular Conformation; D015398:Signal Transduction; D013237:Stereoisomerism
chemical_list: C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP