[Delayed effect of exorphins on learning of albino rat pups].
The delayed effect of food-derived opioid peptides (exorphins) after chronic administration on postnatal days 1-14 on the learning of albino rat pups has been studied. Heptapeptide YPFPGPI (beta-casomorphin-7), pentapeptide YPLDL (rubiscolin-5) and pentapeptide YPISL (exorphin C) improved the development of the conditioned foraging reflex in a complex maze. Hexapeptide PFPGPI lacking the N-terminal tyrosine proved inefficient. Only beta-casomorphin-7 had an effect (negative) on passive avoidance conditioning. The obtained data confirm that exorphins (particularly, milk-derived beta-casomorphins) can have significant and long-term effects on the environmental adaptation of young mammals.
Dubynin
V A
VA
Malinovskaia
I V
IV
Beliaeva
Iu A
IuA
Stovolosov
I S
IS
Bespalova
Zh D
ZhD
Andreeva
L A
LA
Kamenskiĭ
A A
AA
Miasoedov
N F
NF
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D004723:Endorphins / Q000494:pharmacology*; D005260:Female; D006454:Hemoglobins / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects; D018847:Opioid Peptides / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D012273:Ribulose-Bisphosphate Carboxylase / Q000494:pharmacology*
D004723:Endorphins; D006454:Hemoglobins; D018847:Opioid Peptides; D010446:Peptide Fragments; C111722:exorphin C; C443992:rubiscolin 5; C041128:beta-casomorphin 7; D012273:Ribulose-Bisphosphate Carboxylase