title: Green chemistry procedure for the synthesis of cyclic ketals from 2-adamantanone as potential cosmetic odourants.
abstract: Some cyclic ketals derived from 2-adamantanone were obtained in excellent yields by microwave activation under solvent-free conditions, as a 'green chemistry' procedure. A number of experiments were performed to evaluate the most efficient catalytic conditions. The best results were obtained using a simple heterogeneous mixture of reagents and p-toluenesulphonic acid as the catalyst, without any solvent or support. The data are reported and compared with those obtained by other microwave-mediated syntheses or by classical method. In order to check the possible intervention of non-thermal microwave effects, the best experiment in 'dry media' was carried out with considerable lower yield by conventional heating, in a thermostated oil bath, under the same conditions as under microwaves (time, temperature and vessel). All the synthesized compounds were tested for their olfactive character and for a potential cosmetic use. The odour evaluation is reported.
authors.affiliation: Dipartimento Scienze Farmaceutiche dell'Università, Viale Benedetto XV, 3-16132 Genova, Italy.
authors.forename: M T
authors.initials: MT
authors.lastname: Genta
authors.forename: C
authors.initials: C
authors.lastname: Villa
authors.forename: E
authors.initials: E
authors.lastname: Mariani
authors.forename: M
authors.initials: M
authors.lastname: Longobardi
authors.forename: A
authors.initials: A
authors.lastname: Loupy