Subcellular redistribution of trimeric G-proteins--potential mechanism of desensitization of hormone response: internalization, solubilization, down-regulation.
Agonist-induced subcellular redistribution of G-protein coupled receptors (GPCR) and of trimeric guanine-nucleotide binding regulatory proteins (G-proteins) represent mechanisms of desensitization of hormone response, which have been studied in our laboratory since 1989. This review brings a short summary of these results and also presents information about related literature data covering at least small part of research carried out in this area. We have also mentioned sodium plus potassium dependent adenosine triphosphatase (Na, K-ATPase) and 3H-ouabain binding as useful reference standard of plasma membrane purity in the brain.
Drastichová
Z
Z
Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
Bourová
L
L
Lisý
V
V
Hejnová
L
L
Rudajev
V
V
Stöhr
J
J
Durchánková
D
D
Ostasov
P
P
Teisinger
J
J
Soukup
T
T
Novotný
J
J
Svoboda
P
P
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism; D006224:Cricetinae; D015536:Down-Regulation; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D020962:Heterotrimeric GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D006728:Hormones / Q000378:metabolism*; D055503:Protein Multimerization; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013347:Subcellular Fractions / Q000378:metabolism
D006728:Hormones; D043562:Receptors, G-Protein-Coupled; D019204:GTP-Binding Proteins; D020962:Heterotrimeric GTP-Binding Proteins; D000254:Sodium-Potassium-Exchanging ATPase