Regenerative medicine and human models of human disease.
Recent advances in stem-cell technology are now allowing the mechanisms of human disease to be studied in human cells. A new era for regenerative medicine is arising from such disease models, extending beyond early cell-based therapies and towards evaluating genetic variation in humans and identifying the molecular pathways that lead to disease, as well as targets for therapy.
Chien
Kenneth R
KR
Cardiovascular Research Center, Massachusetts General Hospital, Simches Research Center, 185 Cambridge Street, Boston, Massachusetts 02114, USA. kchien@partners.org
D000818:Animals; D004194:Disease; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D051379:Mice; D008954:Models, Biological; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism; D044968:Regenerative Medicine / Q000639:trends