Chemical constituents from the stem bark of Trewia nudiflora L. and their antioxidant activities.
Three new compounds, namely, (+)-dihydrodehydrodiconiferyl alcohol 4- O- beta-(6''- O-galloyl)-glucopyranoside ( 1), 4,4'- O-dimethylellagic acid 3-(2''- O-acetyl)- alpha-rhamnopyranoside ( 2), and ethyl O- beta-(6'-galloyl)-glucopyranoside ( 3), together with eleven known ones, were isolated from the stem bark of Trewia nudiflora. Their structures were elucidated by means of 1D, 2 D NMR and HR-MS analyses. The antioxidant activities of these compounds were evaluated with the DPPH radical-scavenging assay. Compound 1 showed significant antioxidant activity. In addition, compounds 1, 2 and 3 rescued the H (2)O (2)-induced PC12 cell death at 0.4 microM in the MTT assay.
Kang
Qian-Jin
QJ
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.
Yang
Xian-Wen
XW
Wu
Shao-Hua
SH
Ma
Yan-Ling
YL
Li
Ling
L
Shen
Yue-Mao
YM
D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D001713:Biphenyl Compounds; D019665:Euphorbiaceae / Q000737:chemistry*; D006834:Hydrazines; D006861:Hydrogen Peroxide; D015394:Molecular Structure; D016716:PC12 Cells; D010851:Picrates; D024301:Plant Bark / Q000737:chemistry*; D018547:Plant Stems; D011714:Pyrans / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats
D000975:Antioxidants; D001713:Biphenyl Compounds; D006834:Hydrazines; D010851:Picrates; D011714:Pyrans; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl