[Effect of phospholipid- and albumin-coated microbubbles for myocardial opacification: a comparative study].
OBJECTIVE
To evaluate the effect of a phospholipid-coated microbubble contrast agent for myocardium opacification in comparison with a albumin-coated microbubble contrast agent (Quanfuxian).


METHODS
In 10 dogs with single coronary artery stenosis involving the anterior descending branch or circumflex branch randomly received infusion of the two contrast agents through the femoral vein. The myocardial blood flow, heart rate and blood pressure were analyzed qualitatively and quantitatively. The concentration and the particle diameter of the two contrast agents were determined.


RESULTS
The concentration of the phospholipid-coated microbubbles was (1.06-/+0.22) x10(9)/ml, with a diameter of 3.04-/+0.34 microm, similar to the concentration and diameter of Quanfuxian ((1.31-/+0.33)x10(9)/ml and 2.88-/+0.58 microm, respectively, P>0.05). Both of the agents achieved grade three myocardium opacification, and produced no obvious effect on the heart rate and blood pressure. Quantitative analysis of myocardial opacification in terms of myocardial blood volume (A), blood velocity (beta), and blood flow (A x beta) revealed no significant difference between the two agents (P>0.05), and the parameters derived from the two agents showed good correlations (P<0.05, rA=0.809, r beta=0.932, rA.beta=0.925).


CONCLUSIONS
The phospholipid-coated microbubble contrast agent shows good effect for myocardial opacification without significant difference from Quanfuxian. Both of the agents are good ultrasound contrast agents for quantitative analysis of myocardium blood flow.
Chen
Dong-dong
DD
Department of Cardiology, Nanfang hospital, Southern Medical University, Guangzhou 510515, China. lajiao420@163.com
Yang
Li
L
Wu
Jue-fei
JF
Teng
Zhong-hua
ZH
Chen
Shao-min
SM
Huang
Zheng
Z
Bin
Jian-ping
JP
Wu
Ping-sheng
PS
Lai
Yan-xian
YX
D000418:Albumins / Q000737:chemistry; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D004285:Dogs; D004452:Echocardiography / Q000379:methods*; D005260:Female; D008297:Male; D045423:Microbubbles; D010743:Phospholipids / Q000737:chemistry
D000418:Albumins; D003287:Contrast Media; D010743:Phospholipids