Radioprotectant Activity of 5-Diethylsulfonamoylsalicylatocopper(II) in Gamma Irradiated Mice.
Survival and changes in mean body mass of whole-body irradiated mice were determined to examine the radioprotectant activity of 5-diethylsulfonamoylsalicylatocopper(II) [Cu(II) (5-DESS)]. One of four groups of 25 female C57BL/6 mice were treated subcutaneously (sc)with 0, 10, 20, 40, 60, 80, 100, or 120 mumol Cu(II)(5- DESS)/kg of body mass 3 hours before exposure to 8.0 Gy, gamma irradiation. In this paradigm, doses of Cu(II)(5- DESS) increased survival up to 92% above vehicle-treated control mice (P = 0.008). Mean body mass determinations revealed that mice treated with 80 to 120 mumol Cu(II)(5-DESS)/kg of body mass exhibited a smaller decrease in body mass than other complex-treated groups. These results support the hypothesis that Cu(II)(5-DESS) is an effective radioprotectant.
Kuykendall Iii
J A
JA
Research Center University of Arkansas at Pine Bluff Pine Bluff Arkansas 71601 USA.
Simmons Iii
H
H
Irving
H J
HJ
Wear
M A
MA
Sorenson
P G
PG
Tipton
L G
LG
Maddox
K M
KM
Williams
E L
EL
Pham-Tran
V A
VA
Credit
C
C
Chowdhury
I L
IL
Khan
S
S
Tipton
J B
JB
Willingham
W M
WM
Sorenson
J R
JR