title: Early results of the use of ProRoot MT and Titan cement for furcation perforation repair--a comparative experimental study.
abstract: The aim of the present experimental study was to follow up the connective tissue response after using ProRoot MTA and Titan cement to repair furcation perforations in dogs.
  
  
  METHODS
  Four animals aged 12 to 18 months were used in the study. Perforation defects were created in the center of the pulp chamber of mandibular premolars P2, P3 and P4, right and left. The defects on the left side were repaired with ProRoot MTA, and those on the right side--with Titan cement in all dogs. After 30 days bone fragments with teeth included were fixed in formalin and decalcified in 50% formic acid. Serial sections of 10 microm thickness were prepared, stained with hematoxylin and eosin and studied under light microscopy.
  
  
  RESULTS
  The connective tissue response in the Titan cement repaired teeth was a fibrous capsule in contact with the material, with single or aggregated lymphocytes seen in the vicinity. The response to ProRoot MTA was similar, but the fibrous capsule was thinner and without any aggregation of lymphocytes.
  
  
  CONCLUSIONS
  The connective tissue response was similar for both tested materials. The tissues tolerated both of them well; it formed a fibrous capsule, which is indicative of the start of a healing process.
authors.affiliation: Department of Operative Dentistry and Endodontics, Faculty of Dental Medicine, Plovdiv, Bulgaria.
authors.forename: Stoyan B
authors.initials: SB
authors.lastname: Vladimirov
authors.forename: Iva V
authors.initials: IV
authors.lastname: Stamatova
authors.forename: Pepa K
authors.initials: PK
authors.lastname: Atanasova
authors.forename: Georgi
authors.initials: G
authors.lastname: Baltadjiev
authors.forename: Ivan
authors.initials: I
authors.lastname: Borisov
mesh_terms: D017607:Aluminum Compounds; D000818:Animals; D017610:Calcium Compounds; D003238:Connective Tissue / Q000473:pathology; D003738:Dental Cements; D004285:Dogs; D004338:Drug Combinations; D017823:Furcation Defects / Q000473:pathology / Q000601:surgery*; D010087:Oxides; D017640:Silicates
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D003738:Dental Cements; D004338:Drug Combinations; D010087:Oxides; D017640:Silicates; C086631:mineral trioxide aggregate