title: Risk factors for osteoporosis and bone status in postmenopausal women with psoriasis treated with UVB therapy.
abstract: The aims of this study were to examine whether postmenopausal women with psoriasis who were exposed to regular ultraviolet light B (UVB) therapy had greater bone mineral density than women of similar age from the same region, and to estimate the influence of risk factors on bone status. A total of 35 randomly selected women, age (mean +/- SD) 69.3 +/- 6.29 years (age range 60-82 years), with active psoriasis, mean onset at 37.0 years (+/- 23.5 SD) were studied. The patients had been previously exposed to broadband or narrowband UVB. Age-matched, women (n = 2448) from Göteborg, examined at the Geriatric out-patient clinic during the years 2001 and 2002, were used as controls. Bone mineral density was examined by Dual-Energy X-ray Absorptiometry (Hologic Delphi A) at the hip and the lumbar spine. Medical history and lifestyle factors were assessed with a questionnaire. Postmenopausal women with psoriasis were found to have higher bone mineral density than age-matched controls. Higher body weight, physical activity and UVB exposure could explain this finding.
authors.affiliation: Department of Dermatology, Sahlgrenska University Hospital, Göteborg, Sweden. Amra.Osmancevic@vgregion.se
authors.forename: Amra
authors.initials: A
authors.lastname: Osmancevic
authors.forename: Kerstin
authors.initials: K
authors.lastname: Landin-Wilhelmsen
authors.forename: Olle
authors.initials: O
authors.lastname: Larkö
authors.forename: Dan
authors.initials: D
authors.lastname: Mellström
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Wennberg
authors.forename: Lena
authors.initials: L
authors.lastname: Hulthén
authors.forename: Anne-Lene
authors.initials: AL
authors.lastname: Krogstad
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D001835:Body Weight; D015519:Bone Density; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism / Q000453:epidemiology / Q000628:therapy; D008875:Middle Aged; D009043:Motor Activity; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology*; D010298:Parity; D017698:Postmenopause; D011247:Pregnancy; D011565:Psoriasis / Q000453:epidemiology / Q000628:therapy*; D012307:Risk Factors; D013472:Sunlight; D013548:Sweden / Q000453:epidemiology; D014467:Ultraviolet Therapy