title: [Disseminated and fatal adenovirus infection in an immunocompromised child].
abstract: Severe adenovirus (ADV) infections have become increasingly important in immunocompromised patients, mainly in pediatric stem cell transplant recipients. We report a case of disseminated ADV infection leading to death in a 12-year-old stem cell transplant recipient. The diagnosis was confirmed by viral isolation and viral genome detection in tissues and blood. Main issues associated with infection, diagnosis and therapeutic alternatives are reviewed. This case should alert clinicians to suspect and study this agent in high risk patients and highlights the importance of having antiviral drugs for ADV available in Chile.
authors.affiliation: Escuela de Medicina, Departamento de Pediatría, Pontificia Universidad Católica de Chile, Chile. katia@med.puc.cl
authors.forename: Katia
authors.initials: K
authors.lastname: Abarca V
authors.forename: Nicole
authors.initials: N
authors.lastname: Le Corre P
authors.forename: Cecilia
authors.initials: C
authors.lastname: Perret P
authors.forename: Angélica
authors.initials: A
authors.lastname: Wietstruck P
authors.forename: David
authors.initials: D
authors.lastname: Oddó B
authors.forename: Francisco
authors.initials: F
authors.lastname: Barriga C
mesh_terms: D000258:Adenovirus Infections, Human / Q000175:diagnosis* / Q000276:immunology; D002648:Child; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology; D008297:Male; D012720:Severity of Illness Index