title: The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development.
abstract: Solar UV irradiation is an important carcinogen that leads to the development of skin cancer, which is the most common human cancer. However, the receptors that mediate UV-induced skin carcinogenesis have not yet been unequivocally identified. Here we showed that UV irradiation directly activates cannabinoid receptors 1 and 2 (CB1/2). Notably, our data indicated that the absence of the CB1/2 receptors in mice results in a dramatic resistance to UVB-induced inflammation and a marked decrease in UVB-induced skin carcinogenesis. A marked attenuation of UVB-induced activation of mitogen-activated protein kinases and nuclear factor- kappaB was associated with CB1/2 deficiency. These data provide direct evidence indicating that the CB1/2 receptors play a key role in UV-induced inflammation and skin cancer development.
authors.affiliation: Hormel Institute, University of Minnesota, Austin, Minnesota, USA. zgdong@hi.umn.edu
authors.forename: Duo
authors.initials: D
authors.lastname: Zheng
authors.forename: Ann M
authors.initials: AM
authors.lastname: Bode
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.forename: Yong-Yeon
authors.initials: YY
authors.lastname: Cho
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Wei-Ya
authors.initials: WY
authors.lastname: Ma
authors.forename: Zigang
authors.initials: Z
authors.lastname: Dong
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D016328:NF-kappa B / Q000378:metabolism; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism / Q000502:physiology*; D043885:Receptor, Cannabinoid, CB2 / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D014466:Ultraviolet Rays
chemical_list: D016328:NF-kappa B; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2