title: A useful Pd-catalyzed Negishi coupling approach to benzylic sulfonamide derivatives.
abstract: A mild catalytic system to access diversely functionalized benzylic sulfonamides has been developed. Palladium-catalyzed alpha-arylation by Negishi cross-coupling of sulfonamide-stabilized anions and a wide range of aryl iodides, bromides, and triflates constitutes a practical strategy for the synthesis of various benzylic sulfonamides.
authors.affiliation: Department of Medicinal Chemistry, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA. gang.zhou@spcorp.com
authors.forename: Gang
authors.initials: G
authors.lastname: Zhou
authors.forename: Pauline
authors.initials: P
authors.lastname: Ting
authors.forename: Robert
authors.initials: R
authors.lastname: Aslanian
authors.forename: John J
authors.initials: JJ
authors.lastname: Piwinski
mesh_terms: D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001555:Benzene Derivatives; D013449:Sulfonamides; D010165:Palladium