title: Lanostane-type triterpenoids from the roots of Kadsura coccinea.
abstract: Seven new lanostane-type triterpenoids, seco-coccinic acids A-F (1- 6) and coccinilactone A (7), were isolated from the roots of Kadsura coccinea. Their structures were established on the basis of spectroscopic data analysis. The absolute configuration at C-24 of compound 5 was confirmed by the modified Mosher's method. The cell growth inhibitory effects of these compounds were determined in human leukemia HL-60 cells, and it was found that compounds 1, 2, 3, and 5 exhibited antiproliferative effects with GI 50 values ranging from 6.8 to 42.1 microM.
authors.affiliation: Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.forename: Zhanlin
authors.initials: Z
authors.lastname: Li
authors.forename: Dandan
authors.initials: D
authors.lastname: Song
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Hongwei
authors.initials: H
authors.lastname: Fu
authors.forename: Kazuo
authors.initials: K
authors.lastname: Koike
authors.forename: Yuehu
authors.initials: Y
authors.lastname: Pei
authors.forename: Yongkui
authors.initials: Y
authors.lastname: Jing
authors.forename: Huiming
authors.initials: H
authors.lastname: Hua
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D032135:Kadsura / Q000737:chemistry*; D007810:Lanosterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C530889:coccinilactone A; D007810:Lanosterol