title: Au(I)- and Pt(II)-catalyzed cycloetherification of omega-hydroxy propargylic esters.
abstract: Depending on the nature of the metal catalyst, omega-hydroxy propargylic acetates choose between alternative cycloetherification manifolds to produce functionalized heterocycles in high yields. AuCl catalyzes the formation of oxacyclic enol acetates, whereas [Cl(2)Pt(CH(2)CH(2))]2 (Zeise's dimer) will induce a propargylic substitution via an unprecedented S(N)2'-type allenic substitution from within a chelated square planar cationic Pt(II) complex.
authors.affiliation: Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9038, USA. jef.debrabander@utsouthwestern.edu
authors.forename: Jef K
authors.initials: JK
authors.lastname: De Brabander
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Mingxing
authors.initials: M
authors.lastname: Qian
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D004952:Esters; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D010984:Platinum / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D004952:Esters; D020005:Propanols; D010984:Platinum; D006046:Gold