title: [RANTES expression in venous ulceration of lower limbs].
abstract: OBJECTIVE
  To investigate the expression of RANTES in venous ulceration.
  
  
  METHODS
  From patients with lower limb venous ulceration, patients with non-ulcerous venous insufficiency, and healthy individuals, peripheral blood was collected from the lower limb veins for measurement of RANTES mRNA using RT-PCR.
  
  
  RESULTS
  In the ulceration group, the expression of RANTES mRNA was significantly increased as compared with the other two groups (P<0.01). RANTES mRNA expression was also significant higher in the non-ulcerous group than the control group (P<0.01).
  
  
  CONCLUSIONS
  High expression of RANTES mRNA may be one of the important mechanisms of venous ulceration.
authors.affiliation: Department of Vascular Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. chlh22@163.com
authors.forename: Liu-hua
authors.initials: LH
authors.lastname: Chen
authors.forename: Cai-sheng
authors.initials: CS
authors.lastname: Ye
authors.forename: Heng-hui
authors.initials: HH
authors.lastname: Yin
authors.forename: Jie-lian
authors.initials: JL
authors.lastname: Ye
authors.forename: Shen-ming
authors.initials: SM
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D018946:Chemokine CCL5 / Q000096:biosynthesis / Q000097:blood* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014647:Varicose Ulcer / Q000097:blood* / Q000209:etiology; D014689:Venous Insufficiency / Q000097:blood* / Q000150:complications; D055815:Young Adult
chemical_list: D018946:Chemokine CCL5; D012333:RNA, Messenger