Downregulation of the phosphatase nuclear targeting subunit (PNUTS) triggers pRB dephosphorylation and apoptosis in pRB positive tumor cell lines.
Graña
Xavier
X
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA. xavier@temple.edu
D017209:Apoptosis; D002453:Cell Cycle; D045744:Cell Line, Tumor; D050719:Crk-Associated Substrate Protein / Q000096:biosynthesis; D018844:Cyclin-Dependent Kinases / Q000096:biosynthesis; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000502:physiology*; D050687:E2F1 Transcription Factor / Q000096:biosynthesis; D006801:Humans; D008954:Models, Biological; D009687:Nuclear Proteins / Q000096:biosynthesis* / Q000502:physiology*; D010766:Phosphorylation; D054648:Protein Phosphatase 2 / Q000096:biosynthesis; D016601:RNA-Binding Proteins / Q000096:biosynthesis* / Q000502:physiology*; D016160:Retinoblastoma Protein / Q000096:biosynthesis*
C493841:BCAR1 protein, human; D050719:Crk-Associated Substrate Protein; D004268:DNA-Binding Proteins; D050687:E2F1 Transcription Factor; D009687:Nuclear Proteins; C110225:PPP1R10 protein, human; D016601:RNA-Binding Proteins; D016160:Retinoblastoma Protein; D018844:Cyclin-Dependent Kinases; D054648:Protein Phosphatase 2