[Changes of insulin-like growth factor-I in focal cerebral ischemical reperfusion injury in rats].
OBJECTIVE
To study the changes of insulin-like growth factor-I (IGF-I) in focal cerebral ischemical reperfusion injury model.


METHODS
Focal cerebral ischemia was induced in rats using filament method, and the expressions of IGF-I was detected with immunohistochemical staining.


RESULTS
The expression of IGF-I was very low in normal brain tissues, but increased in the infracted area and penumbra after cerebral ischemia. The expressions of IGF-I reached the peak level of 14.83-/+0.48 at days 3 after reperfusion.


CONCLUSIONS
Focal cerebral ischemia reperfusion injury enhances the expression of endogenous IGF-I.
Wu
Hong-ying
HY
Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. wuhymail@126.com
Fan
Jiang-zhong
JZ
Luo
Ren
R
Li
Chuan
C
Wei
Yi
Y
D000818:Animals; D005260:Female; D007150:Immunohistochemistry; D020244:Infarction, Middle Cerebral Artery / Q000378:metabolism / Q000473:pathology; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000378:metabolism*
D007334:Insulin-Like Growth Factor I