title: Optical intrinsic signal mapping of rod- and cone-mediated visual cortex responses in mice.
abstract: We used optical imaging of intrinsic signals to study visual cortex responses in three mouse strains: wild-type (C57BL/6J), a strain with only rod function (cpfl1), and a strain with only cone function (rho(-/-)). A stationary flicker light stimulus with intensity ranging from 10(8.6) to 10(15.5) photons/cm2/s was used. We found that the intrinsic signal patterns exhibited stimulus intensity-dependent changes. At a given stimulus intensity, the patterns of intrinsic signals were clearly different in the three strains. These results suggest that the lack of normal functions of certain photoreceptors induces significant reorganization in the visual neural systems in mice.
authors.affiliation: Department of Biological Engineering, University of Missouri-Columbia, 1406 E Rollins Street, 249 Ag Eng Building, Columbia, MO 65211, USA.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Fan
authors.forename: Bo
authors.initials: B
authors.lastname: Lei
authors.forename: Keqing
authors.initials: K
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Yao
mesh_terms: D000818:Animals; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009473:Neuronal Plasticity / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods; D017949:Retinal Cone Photoreceptor Cells / Q000502:physiology*; D017948:Retinal Rod Photoreceptor Cells / Q000502:physiology*; D012243:Rhodopsin / Q000172:deficiency / Q000235:genetics; D012815:Signal Processing, Computer-Assisted; D014793:Visual Cortex / Q000502:physiology*
chemical_list: D012243:Rhodopsin