Along came a spider: AID escapes a microRNA web.
In this issue of Immunity, Teng et al. (2008) and Dorsett et al. (2008) report that activation-induced cytidine deaminase in B cells is repressed by microRNA-155. Relief of repression is associated with defective affinity maturation and increased Myc-Igh translocations.
Desiderio
Stephen
S
Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. sdesider@jhmi.edu
D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology* / Q000276:immunology / Q000378:metabolism; D003564:Cytidine Deaminase / Q000235:genetics / Q000378:metabolism*; D005803:Genes, Immunoglobulin; D016259:Genes, myc; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D051379:Mice; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D014178:Translocation, Genetic; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D007143:Immunoglobulin Heavy Chains; D035683:MicroRNAs; D011993:Recombinant Fusion Proteins; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase