Colletoic acid, a novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitor from Colletotrichum gloeosporioides SANK 21404.
Colletoic acid, a novel 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor, was found and isolated from the cultured broth of the producing fungus Colletotrichum gloeosporioides SANK 21404. Its structure was determined to be a novel acorene-type sesquiterpene by several spectroscopic methods. The absolute structure of colletoic acid was established using a modified Mosher's method and single-crystal X-ray diffraction analysis.
Aoyagi
Azusa
A
Advanced Technology Research Laboratories, Daiichi Sankyo Co., Ltd, Shinagawa-ku, Tokyo, Japan.
Ito-Kobayashi
Mariko
M
Ono
Yasunori
Y
Furukawa
Yoji
Y
Takahashi
Mizuki
M
Muramatsu
Yasunori
Y
Umetani
Megumi
M
Takatsu
Toshio
T
D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000037:antagonists & inhibitors*; D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2 / Q000037:antagonists & inhibitors; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D020231:Colletotrichum / Q000737:chemistry* / Q000145:classification; D018360:Crystallography, X-Ray; D003517:Cyclopentanes / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004952:Esters / Q000138:chemical synthesis; D005285:Fermentation; D006801:Humans; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D012717:Sesquiterpenes; D013141:Spiro Compounds / Q000737:chemistry / Q000494:pharmacology*
D003517:Cyclopentanes; D004791:Enzyme Inhibitors; D004952:Esters; D012717:Sesquiterpenes; D013141:Spiro Compounds; C532324:colletoic acid; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1; D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2