title: Ventilation strategies and adjunctive therapy in severe lung disease.
abstract: Respiratory failure caused by severe lung disease is a common reason for admission to the pediatric and neonatal intensive care units. Efforts to decrease morbidity and mortality have fueled investigations into innovative methods of ventilation, kinder gentler ventilation techniques, pharmacotherapeutic adjuncts, and extracorporeal life support modalities. This article discusses the rationale for and experience with some of these techniques.
authors.affiliation: Department of Pediatrics, University of British Columbia, Children's Hospital, Room K4-105, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada. nkissoon@cw.bc.ca
authors.forename: Niranjan
authors.initials: N
authors.lastname: Kissoon
authors.forename: Peter C
authors.initials: PC
authors.lastname: Rimensberger
authors.forename: Desmond
authors.initials: D
authors.lastname: Bohn
mesh_terms: D000280:Administration, Inhalation; D002648:Child; D005112:Extracorporeal Circulation / Q000592:standards*; D016166:Free Radical Scavengers / Q000008:administration & dosage; D006371:Helium / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D008171:Lung Diseases / Q000401:mortality / Q000628:therapy*; D009569:Nitric Oxide / Q000008:administration & dosage*; D010100:Oxygen / Q000008:administration & dosage / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic; D012121:Respiration, Artificial / Q000592:standards*; D012720:Severity of Illness Index; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome
chemical_list: D016166:Free Radical Scavengers; D006371:Helium; D009569:Nitric Oxide; C038949:heliox; D010100:Oxygen