The role of serpins in vertebrate immunity.
Serine proteases are important components of the immune system, playing a role in many processes including migration, phagocytosis and elimination of virally infected and cancerous cells. Members of the serpin superfamily regulate the activity of these proteases to limit tissue damage and unwarranted cell death. This review focuses on the role of intracellular (clade B) serpins in maintaining viability of both innate and adaptive immune cells.
Mangan
M S J
MS
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
Kaiserman
D
D
Bird
P I
PI
D000818:Animals; D006801:Humans; D007107:Immune System / Q000201:enzymology* / Q000276:immunology* / Q000473:pathology; D018836:Inflammation Mediators / Q000737:chemistry / Q000145:classification / Q000502:physiology; D005810:Multigene Family; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000502:physiology*; D015843:Serpins / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000502:physiology*; D014714:Vertebrates / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*
D018836:Inflammation Mediators; D015842:Serine Proteinase Inhibitors; D015843:Serpins