SNIP/p140Cap mRNA expression is an unfavourable prognostic factor in breast cancer and is not expressed in normal breast tissue.
The prevalence and clinical relevance of SNIP/p140Cap has not been extensively investigated. Here SNIP/p140Cap mRNA expression was studied in 103 breast tumour biopsies, where it was detected in approximately 37% of tumour specimens, but not in any normal breast specimens. Expression correlated significantly with unfavourable overall survival. This suggests that SNIP/p140Cap may be a useful diagnostic and prognostic marker for breast cancer and its expression in breast cancer, but not in normal breast tissue, suggests that it may have potential as a therapeutic target.
Kennedy
S
S
St Vincent's University Hospital, Dublin 4, Ireland.
Clynes
M
M
Doolan
P
P
Mehta
J P
JP
Rani
S
S
Crown
J
J
O'Driscoll
L
L
D033942:Adaptor Proteins, Vesicular Transport; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001940:Breast / Q000378:metabolism; D001943:Breast Neoplasms / Q000098:blood supply / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology*; D002280:Basal Cell Carcinoma / Q000201:enzymology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism*; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012878:Skin Neoplasms / Q000201:enzymology; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
D033942:Adaptor Proteins, Vesicular Transport; D014408:Biomarkers, Tumor; C532615:SRCIN1 protein, human; D025521:Tumor Suppressor Proteins; D020781:Matrix Metalloproteinase 1