title: Knigth's Move in the Periodic Table, From Copper to Platinum, Novel Antitumor Mixed Chelate Copper Compounds, Casiopeinas, Evaluated by an in Vitro Human and Murine Cancer Cell Line Panel.
abstract: We synthesized a novel anticancer agents based on mixed chelate copper (II) complexes, named Casiopeínas((R)) has of general formula [Cu(N-N)(N-O)H(2)O]NO(3) (where, N-N = diimines as 1,10- phenanthroline, 2,2-bipyridine, or substituted and N-O=aminoeidate or [Cu(N-N)(O-O)H(2)O]NO(3) (where NN= diimines as 10-phenanthroline, 2,2-bipyridine or substituted Casiopeínas I, II, IV, V, VI, VII VIII and O-O=acetylacetonate, salicylaldehidate Casiopínas III). We evaluated the in vitro antitumor activity using a human cancer cell panel and some nurine cancer cells. Eleven Casiopeinas are evaluated in order to acquire some structure-activity correlations and some monodentated Casiopeinäs analogues; cisplatinum was used as control drug. The 50% growth inhibition observed is, in all cases reach with concentrations of Casiopeina's 10 or 100 times lower than cisplatinum. In a previous work we reported the induction of apoptosis by Casiopeina II. The results indicate that Casiopeinass are a promising new anticancer drug candidates to be developed further toward clinical trials.
authors.affiliation: Inorganic Chemistry Department Faculty of Chemistry, UNAM Mexico City Z.P. 04510 Mexico.
authors.forename: I
authors.initials: I
authors.lastname: Gracia-Mora
authors.forename: L
authors.initials: L
authors.lastname: Ruiz-Ramírez
authors.forename: C
authors.initials: C
authors.lastname: Gómez-Ruiz
authors.forename: M
authors.initials: M
authors.lastname: Tinoco-Méndez
authors.forename: A
authors.initials: A
authors.lastname: Márquez-Quiñones
authors.forename: L R
authors.initials: LR
authors.lastname: Lira
authors.forename: A
authors.initials: A
authors.lastname: Marín-Hernández
authors.forename: L
authors.initials: L
authors.lastname: Macías-Rosales
authors.forename: M E
authors.initials: ME
authors.lastname: Bravo-Gómez