Is zinc a neuromodulator?
The vesicles of certain glutamatergic terminals in the mammalian forebrain are replete with ionic zinc. It is believed that during synaptic transmission zinc is released, binds to receptors on the pre- or postsynaptic membranes, and hence acts as a neuromodulator. Although exogenous zinc modulates a wide variety of channels, whether synaptic zinc transits across the synaptic cleft and alters the response of channels has been difficult to establish. We will review the evidence for zinc as a neuromodulator and propose diagnostic criteria for establishing whether it is indeed one. Moreover, we will delineate alternative ways in which zinc might act at synapses.
Kay
Alan R
AR
Department of Biology, 336 BB, University of Iowa, Iowa City, IA 52242, USA. alan-kay@uiowa.edu
Tóth
Katalin
K
D000818:Animals; D006801:Humans; D018377:Neurotransmitter Agents; D013569:Synapses / Q000737:chemistry; D009435:Synaptic Transmission; D015032:Zinc / Q000378:metabolism / Q000502:physiology*
D018377:Neurotransmitter Agents; D015032:Zinc