2-Methoxycyclopentyl analogues of a Pseudomonas aeruginosa quorum sensing modulator.
Diastereomeric 2-methoxycyclopentyl analogues of a natural quorum sensing signaling molecule from Pseudomonas aeruginosa were synthesized and screened in pigment production assays with P. aeruginosa and Serratia strain ATCC39006.
Lee
Lydia Y W
LY
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
Hupfield
Timothy
T
Nicholson
Rebecca L
RL
Hodgkinson
James T
JT
Su
Xianbin
X
Thomas
Gemma L
GL
Salmond
George P C
GP
Welch
Martin
M
Spring
David R
DR
D001665:Binding Sites; D004305:Dose-Response Relationship, Drug; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000502:physiology*; D053038:Quorum Sensing / Q000187:drug effects*; D012705:Serratia / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship