Pyronane monoterpenoids from the fruit of Gardenia jasminoides.
Five new pyronane-type monocyclic monoterpenoids, jasminodiol (1), jasminoside H (6), 6'-O-sinapoyljasminoside A (7), 6'-O-sinapoyljasminoside C (8), and jasminoside I (9), together with four known analogues, were isolated from the fruit of Gardenia jasminoides. The structures of the new metabolites were characterized using spectroscopic data, and the absolute configurations of 1, 6, and 7 were established using circular dichroism (CD) analysis. Compound 1 showed tyrosinase inhibitory activity (IC 50 2.2 mM).
Chen
Quan Cheng
QC
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
Youn
UiJoung
U
Min
Byung-Sun
BS
Bae
KiHwan
K
D000363:Agaricales / Q000201:enzymology; D002942:Circular Dichroism; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry; D032062:Gardenia / Q000737:chemistry*; D007723:Korea; D007980:Levodopa / Q000494:pharmacology; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*
C530892:6'-O-sinapoyljasminoside A; C530893:6'-O-sinapoyljasminoside C; D039821:Monoterpenes; C530890:jasminodiol; C530891:jasminoside H; C530894:jasminoside I; D007980:Levodopa; D014442:Monophenol Monooxygenase