title: Natural product isolation.
abstract: Since the 1990s, interest in natural product research has increased considerably. Following several outstanding developments in the areas of separation methods, spectroscopic techniques, and sensitive bioassays, natural product research has gained new attention for providing novel chemical entities. This updated review deals with sample preparation and purification, recent extraction techniques used for natural product separation, liquid-solid and liquid-liquid isolation techniques, as well as multi-step chromatographic operations. It covers examples of papers published since the NPR review 'Modern separation methods' by Marston and Hostettmann,1 with major emphasis on methods developed and the research undertaken since 2000.
authors.affiliation: Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Zurich 8093, Switzerland.
authors.forename: Otto
authors.initials: O
authors.lastname: Sticher
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification*; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods; D015394:Molecular Structure
chemical_list: D001688:Biological Products