title: Pregabalin-induced cortical negative myoclonus in a patient with neuropathic pain.
abstract: Myoclonus is a well-known side effect of anticonvulsant drugs. Pregabalin is one of the newer drugs approved for the treatment of focal epilepsies. Frequently it is also used to treat chronic pain syndromes. We describe a patient who, after receiving his first dose of pregabalin to relieve neuropathic pain, presented with a negative myoclonus. Clinical aspects and electrophysiological data such as polygraphic studies, electroencephalography, and measurement of somatosensory evoked potentials support the cortical origin of negative myoclonus. Our findings reveal that even in patients without a history of seizures, pregabalin can cause a cortical negative myoclonus.
authors.forename: Sabine
authors.initials: S
authors.lastname: Hellwig
authors.forename: Florian
authors.initials: F
authors.lastname: Amtage
mesh_terms: D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D020968:Brachial Plexus Neuritis / Q000188:drug therapy*; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D004401:Dysarthria / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D004558:Electric Stimulation; D004569:Electroencephalography / Q000187:drug effects*; D004576:Electromyography / Q000187:drug effects; D004831:Epilepsies, Myoclonic / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation; D000069583:Pregabalin; D013003:Somatosensory Cortex / Q000187:drug effects / Q000503:physiopathology; D013979:Tibial Nerve / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid