title: Severe symptomatic hyponatremia during sibutramine therapy: a case report.
abstract: Sibutramine, a serotonin reuptake inhibitor, currently is used in treatment of obesity. The known side effects of sibutramine, ie, hypertension and tachycardia, depend on its adrenergic and serotoninergic effects. We describe a case of life-threatening hyponatremia associated with sibutramine use in an obese woman. We hypothesize that sibutramine, through its effect on neurotransmitters, may induce antidiuretic hormone secretion and lead to a syndrome of inappropriate antidiuretic hormone secretion. We advise careful monitoring of water-electrolytic balance during sibutramine therapy.
authors.affiliation: Unit of Nephrology, Dialysis, and Transplantation, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy. pasqualeesposito@hotmail.com
authors.forename: Pasquale
authors.initials: P
authors.lastname: Esposito
authors.forename: Teresa
authors.initials: T
authors.lastname: Rampino
authors.forename: Marilena
authors.initials: M
authors.lastname: Gregorini
authors.forename: Grazia
authors.initials: G
authors.lastname: Soccio
authors.forename: Giovanni
authors.initials: G
authors.lastname: Piotti
authors.forename: Giulia
authors.initials: G
authors.lastname: Bedino
authors.forename: Chiara Teresa
authors.initials: CT
authors.lastname: Balenzano
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Roscini
authors.forename: Laura
authors.initials: L
authors.lastname: Cosmai
authors.forename: Valentina
authors.initials: V
authors.lastname: Portalupi
authors.forename: Carmelo
authors.initials: C
authors.lastname: Libetta
authors.forename: Antonio
authors.initials: A
authors.lastname: Dal Canton
mesh_terms: D001067:Appetite Depressants / Q000008:administration & dosage / Q000009:adverse effects*; D015992:Body Mass Index; D003503:Cyclobutanes / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004636:Emergency Service, Hospital; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D007177:Inappropriate ADH Syndrome / Q000175:diagnosis; D008875:Middle Aged; D009767:Obesity, Morbid / Q000175:diagnosis / Q000188:drug therapy*; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D001067:Appetite Depressants; D003503:Cyclobutanes; C058254:sibutramine