title: 4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function.
abstract: The T box transcription antitermination system is a riboswitch found primarily in Gram-positive bacteria which monitors the aminoacylation of the cognate tRNA and regulates a variety of amino acid-related genes. Novel 4,5-disubstituted oxazolidinones were identified as high affinity RNA molecular effectors that modulate the transcription antitermination function of the T box riboswitch.
authors.affiliation: Department of Chemistry & Biochemistry, Ohio University, Athens, OH 45701, USA.
authors.forename: Rajaneesh
authors.initials: R
authors.lastname: Anupam
authors.forename: Abhijit
authors.initials: A
authors.lastname: Nayek
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Green
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Grundy
authors.forename: Tina M
authors.initials: TM
authors.lastname: Henkin
authors.forename: John A
authors.initials: JA
authors.lastname: Means
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Bergmeier
authors.forename: Jennifer V
authors.initials: JV
authors.lastname: Hines
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001412:Bacillus subtilis / Q000235:genetics; D015195:Drug Design; D008968:Molecular Conformation; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012329:RNA, Bacterial / Q000187:drug effects* / Q000235:genetics; D012343:RNA, Transfer / Q000187:drug effects* / Q000235:genetics; D013237:Stereoisomerism; D013728:Terminator Regions, Genetic / Q000187:drug effects / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D012329:RNA, Bacterial; D012343:RNA, Transfer