Motor variant of chronic inflammatory demyelinating polyneuropathy in a child.
Only 2 cases of pure motor chronic demyelinating inflammatory polyneuropathy in the pediatric age group have been reported in the literature. We report on a motor variant of chronic demyelinating inflammatory polyneuropathy with anti-ganglioside antibodies, diagnosed in a 5-year-old girl who presented with progressive motor weakness over a period of 12 months with no sensory involvement. She initially responded partially to intravenous immunoglobulin therapy (1 gm/kg/month for 6 months), and then demonstrated sustained but incomplete improvement on chronic prednisone therapy (1-2 mg/kg/day), on which she has continued since 1 year and 4 months after her initial presentation 3 years ago.
Sinno
Durriyah D
DD
Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Darras
Basil T
BT
Yamout
Bassem I
BI
Rebeiz
Jean G
JG
Mikati
Mohamad A
MA
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D002675:Child, Preschool; D004568:Electrodiagnosis; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D016472:Motor Neuron Disease / Q000134:cerebrospinal fluid / Q000473:pathology / Q000503:physiopathology*; D018908:Muscle Weakness / Q000209:etiology; D009431:Neural Conduction; D011115:Polyneuropathies / Q000134:cerebrospinal fluid / Q000473:pathology / Q000503:physiopathology*; D011241:Prednisone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D011241:Prednisone