title: Radiosurgery with a linear accelerator in cerebral arteriovenous malformations.
abstract: OBJECTIVE
  To evaluate results achieved with radiosurgery and complications of the procedure when treating arteriovenous malformations with linear accelerator.
  
  
  METHODS
  This retrospective study was conducted between October 1993 and December 1996. Sixty-one patients with arteriovenous malformations were treated with radiosurgery utilizing a 6MV energy linear accelerator. Ages of the 32 female and 29 male patients ranged from 6 to 54 years (mean: 28.3 years). The most frequent initial symptom was cephalea (45.9%), followed by neurological deficit (36.1%). Cerebral hemorrhage diagnosed by image was observed in 35 patients (57.3%). Most arteriovenous malformations (67.2%) were graded Spetzler III and IV. Venous stenosis (21.3%) and aneurysm (13.1%) were the most frequent angioarchitecture changes. The dose administered varied from 12 to 27.5Gy in the periphery of the lesion.
  
  
  RESULTS
  Out of twenty-eight patients that underwent conclusive angiography control, complete obliteration was achieved in 18 (72%) and treatment failed in 7 (absence of occlusion with more than 3 years of follow-up). Four were submitted to a second radiosurgery, and one of these has shown obliteration after 18 months of follow-up.
  
  
  CONCLUSIONS
  Several factors were analyzed regarding the occlusion rate (gender, age, volume, localization, Spetzler, flow, embolization, total of isocenters, prescribed dose and chosen isodose) and complications (total of isocenters, localization, volume, maximum dose, prescribed dose and chosen isodose). Analyzed variables showed no statistical significance for obliteration of the vessel, as well as for treatment complications. The largest diameter of the arteriovenous malformation, its volume and the dose administered did not influence time of obliteration.
  
  
  CONCLUSIONS
  Radiosurgery is effective in the treatment of arteriovenous malformations and can be an alternative for patients with clinical contraindication or with lesions in eloquent areas. In the studied variables no statistically significant correlation was observed between occlusion and treatment complications.
authors.affiliation: Hospital Beneficência Portuguesa de São Paulo, São Paulo, SP. estevesrt@uol.com.br
authors.forename: Sérgio Carlos Barros
authors.initials: SC
authors.lastname: Esteves
authors.forename: Wladimir
authors.initials: W
authors.lastname: Nadalin
authors.forename: Ronie Leo
authors.initials: RL
authors.lastname: Piske
authors.forename: Salomon
authors.initials: S
authors.lastname: Benabou
authors.forename: Evandro de
authors.initials: Ed
authors.lastname: Souza
authors.forename: Antonio Carlos Zuliani de
authors.initials: AC
authors.lastname: Oliveira
mesh_terms: D000293:Adolescent; D000328:Adult; D002543:Cerebral Hemorrhage / Q000175:diagnosis; D002648:Child; D004307:Dose-Response Relationship, Radiation; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery*; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D010315:Particle Accelerators; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D016896:Treatment Outcome; D055815:Young Adult