title: Rhabdomyolysis induced by Pseudomonas aeruginosa sepsis.
abstract: We describe advanced hemodynamic insufficiency and remarkably high myoglobinemia in a 77-year-old man who was admitted to the intensive care unit after total aortic arch replacement. Serum myoglobin showed an unusually high value (peak value, 155,030 ng x ml(-1)). The patient died of sepsis and untreatable metabolic acidosis. Pseudomonas aeruginosa was detected in blood culture specimens after his death. On histopathological examination, dense congregations of gram-negative bacilli were present in clots in blood vessels, while congregations of gram-negative bacilli around the circumference of small blood vessels were particularly apparent in every specimen examined. Moreover, a generalized breakdown of muscle fibers, consistent with findings of rhabdomyolysis, was observed in muscle tissue throughout the body.
authors.affiliation: Intensive Care Unit, Osaka University Hospital, Suita, Osaka, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Iguchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Fujino
authors.forename: Akinori
authors.initials: A
authors.lastname: Uchiyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Hirao
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ohta
authors.forename: Takashi
authors.initials: T
authors.lastname: Mashimo
authors.forename: Eiichi
authors.initials: E
authors.lastname: Morii
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009211:Myoglobin / Q000097:blood; D011552:Pseudomonas Infections / Q000150:complications*; D011550:Pseudomonas aeruginosa; D012206:Rhabdomyolysis / Q000209:etiology* / Q000473:pathology; D018805:Sepsis / Q000150:complications* / Q000473:pathology
chemical_list: D009211:Myoglobin