title: Primary intimal aortic angiosarcoma in a dog.
abstract: A primary intimal aortic angiosarcoma was diagnosed in a 4-year-old, spayed female German Shepherd that presented for complications of thromboembolic disease because of infarcts in multiple organs. On gross examination, aneurysmal dilatation of the aorta was associated with a friable, necrotic mass attached to the endothelial surface, which partially occluded the aortic lumen. On histologic examination, plump neoplastic spindle cells formed a plaque-like mass arising from the intima that merged with a large accumulation of fibrin and necrotic debris, and projected into the lumen. Neoplastic cells invaded periaortic vessels and were seen in some infarct-associated thromboemboli. Tumor cells expressed vimentin and CD31, with infrequent, patchy staining with factor VIII-related antigen; tumor cells were negative for cytokeratin and smooth-muscle actin. Aortic angiosarcoma is a rare malignancy in humans. This is the first description of a primary intimal aortic angiosarcoma in a dog, with immunohistochemical evidence of endothelial origin.
authors.affiliation: Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Ranck
authors.forename: K E
authors.initials: KE
authors.lastname: Linder
authors.forename: M D
authors.initials: MD
authors.lastname: Haber
authors.forename: D J
authors.initials: DJ
authors.lastname: Meuten
mesh_terms: D000818:Animals; D001018:Aortic Diseases / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005065:Euthanasia; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006394:Hemangiosarcoma / Q000473:pathology / Q000662:veterinary*; D009919:Orchiectomy / Q000662:veterinary; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D017539:Tunica Intima / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D019408:Platelet Endothelial Cell Adhesion Molecule-1; D014746:Vimentin; D005169:Factor VIII