Biomolecule-assisted synthesis of water-soluble silver nanoparticles and their biomedical applications.
The application of nanoparticles in the biomedical field is an exciting interdisciplinary research area in current materials science. In the present study, size-tunable and water-soluble noble metal silver nanoparticles (Ag NPs) have been successfully synthesized with the assistance of glutathione (GSH). The as-synthesized Ag NPs are ready to bind covalently with a model protein (bovine serum albumin) in mild conditions. The optical property of surface-modifiable Ag NPs was extremely sensitive to their size and the surface modification, suggesting a potential in the biomedical analysis and detection. Furthermore, Ag NPs with an average diameter of ca. 6 nm effectively suppress the proliferation of human leukemic K562 cells in the dose- and time-dependent manners, suggesting the promising potential of Ag NPs in cancer therapy.
Wu
Qingzhi
Q
Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Cao
Huaqiang
H
Luan
Qiuying
Q
Zhang
Jiyong
J
Wang
Zhao
Z
Warner
Jamie H
JH
Watt
Andrew A R
AA
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020014:K562 Cells; D007938:Leukemia / Q000188:drug therapy; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use*; D010316:Particle Size; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D012834:Silver; D012995:Solubility; D013499:Surface Properties; D014867:Water
D000970:Antineoplastic Agents; D012709:Serum Albumin; D014867:Water; D012834:Silver