[Chaperon-like anticataract agents, the antiaggregants of lens crystallin. Communication 4. Study of the effect of a mixture of di- and tetrapeptides on a prolonged rat model of UV-induced cataract].
There is a potential of therapeutic action on certain stages of caractogenesis, in particular on the aggregation of water-soluble proteins of cytoplasmic lens fiber cells, giving rise to insoluble protein complexes. The effect of a combined preparation (N-acetyl carnosine and D-patethine), acting by the chaperon-like mechanism, was studied in vivo on a prolonged rat model of UV-induced cataract. The use of the combined preparation consisting of a mixture of peptides of N-acetyl carnosine and D-patethine in a ratio of 1:1 as ocular instillations and intraperitoneal injections could slow down the development of UV-induced cataract in vivo. Pathomorphological studies suggest that the combined preparation has a protective effect on lens tissue when the rat model of UV-induced cataract is employed.
Avetisov
S E
SE
Polunin
G S
GS
Sheremet
N L
NL
Makarov
I A
IA
Fedorov
A A
AA
Karpova
O E
OE
Muranov
K O
KO
Dizhevskaia
A K
AK
Soustov
L V
LV
Chelnokov
E V
EV
Bitiurin
N M
NM
Sapogova
N V
NV
Nemov
V V
VV
Bodyrev
A A
AA
Ostrovskiĭ
M A
MA
D000818:Animals; D002336:Carnosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002386:Cataract / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D003459:Crystallins / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D004195:Disease Models, Animal; D018450:Disease Progression; D005500:Follow-Up Studies; D007908:Lens, Crystalline / Q000378:metabolism* / Q000473:pathology / Q000528:radiation effects; D008297:Male; D018832:Molecular Chaperones / Q000627:therapeutic use*; D009842:Oligopeptides / Q000627:therapeutic use; D011379:Prognosis; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects
D003459:Crystallins; D018832:Molecular Chaperones; D009842:Oligopeptides; C033681:N-acetylcarnosine; D002336:Carnosine