Aspects of immunopathogenic mechanisms of HIV infection.
Human immunodeficiency virus (HIV) infection is characterized by progressive deterioration of the immune system nearly always resulting in death. Depletion in the numbers of CD4+ T cells is the hallmark of HIV infection and is central to the development of the clinical signs and symptoms that are characteristic of HIV disease. Other factors influencing the progression of HIV disease include the HIV viral load, the nature of the particular infecting HIV, and the level of competence of the immune effector cells.
Feller
L
L
Department of Periodontology and Oral Medicine, Box D26, Faculty of Dentistry, Medunsa Campus 0204, University of Limpopo. lfeller@medunsa.ac.za
Lemmer
J
J
D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D007157:Immunologic Surveillance; D013602:T-Lymphocytes, Cytotoxic / Q000502:physiology; D019562:Viral Load
D016207:Cytokines