[Compensatory effect of selank on the mnestic functions disturbed by neurotoxic damage of the noradrenergic system of the rat brain].
It has been shown that the peptide anxiolytic drug Selank recovers learning and memory impaired by damage of the noradrenergic (NA) brain system in Wistar rats after injection of the NA-synthesis inhibitor disulfiram, administration of neurotoxic compound 6-OHDA, or a combined induction of hypoxic hypoxia and hypercapnia. The main component of the Selank action is the stimulation of the search reflex aimed to distinguish an adequate adaptive response in the first trials of the learning session. The enhancement of memory consolidation and retrieval shows evidence for stimulation of the brain motivation mechanisms impaired by the NA system damage.
Kozlovskiĭ
I I
II
Belozertsev
Iu F
IuF
Semenova
T P
TP
Zuĭkov
A V
AV
Kozlovskaia
M M
MM
D000818:Animals; D000831:Animals, Newborn; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D004221:Disulfiram / Q000633:toxicity; D004924:Escape Reaction / Q000187:drug effects*; D006935:Hypercapnia / Q000378:metabolism / Q000523:psychology; D000860:Hypoxia / Q000378:metabolism / Q000523:psychology; D008297:Male; D008568:Memory / Q000187:drug effects*; D009638:Norepinephrine / Q000378:metabolism*; D009842:Oligopeptides / Q000494:pharmacology*; D016627:Oxidopamine / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
D014151:Anti-Anxiety Agents; D009842:Oligopeptides; D016627:Oxidopamine; D004221:Disulfiram; C100827:TP 7; D009638:Norepinephrine