New polyphenolic beta-lactams with antioxidant activity.
Novel 4-alkylidene-beta-lactams with a polyphenolic side chain were synthesized and evaluated as radical scavengers. We have undertaken a detailed study of the antioxidant activity in vitro with chemical and biological testing of the new beta-lactams and of the corresponding methyl polyhydroxy benzoates. Antioxidant activity of beta-lactams and methyl benzoates was measured with the Briggs-Rauscher oscillating reaction, the TEAC (Trolox( Equivalent Antioxidant Capacity) assay, and as ability to inhibit ROS (=Reactive Oxygen Species) production on myoblast H9c2 cells. The results were discussed with regard to mechanism and correlated with structural parameters.
Cainelli
Gianfranco
G
Dipartimento di Chimica G. Ciamician, Università di Bologna, Via Selmi 2, I-40126 Bologna, Italy.
Angeloni
Cristina
C
Cervellati
Rinaldo
R
Galletti
Paola
P
Giacomini
Daria
D
Hrelia
Silvana
S
Sinisi
Riccardo
R
D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology*; D001565:Benzoates / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D059808:Polyphenols; D013329:Structure-Activity Relationship; D047090:beta-Lactams / Q000138:chemical synthesis / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology*
D000975:Antioxidants; D001565:Benzoates; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D047090:beta-Lactams; C044605:methyl benzoate