Total synthesis of (-)-corilagin.
The synthesis of corilagin was achieved by the integration of the development of the oxidative coupling of the symmetrically protected gallates and the temporarily ring-opened synthetic route for the 3,6-hexahydroxydiphenoyl (HHDP) bridge. This is the first total synthesis of the 1C4/B-ellagitannins, which contain ring-flipped glucose.
Yamada
Hidetoshi
H
School of Science and Technology, Kwansei Gakuin University, Sanda 669-1337, Japan. hidetosh@kwansei.ac.jp
Nagao
Kohei
K
Dokei
Kazutoyo
K
Kasai
Yusuke
Y
Michihata
Naoki
N
D005707:Gallic Acid / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D005960:Glucosides / Q000138:chemical synthesis*; D047348:Hydrolyzable Tannins; D008722:Methods
D005960:Glucosides; D047348:Hydrolyzable Tannins; C049096:corilagin; D005707:Gallic Acid; D005947:Glucose