[Rapid differential diagnosis of thalassemia trait and iron-deficiency anemia with stepwise regression analysis].
OBJECTIVE
To establish a method for rapid differential diagnosis of thalassemia trait (TT) and iron-deficiency anemia (IDA) using stepwise regression analysis.


METHODS
Stepwise regression equation was established for differential diagnosis of TT and IDA according to the red cell index, and the accuracy of the differential diagnosis was evaluated using blind analysis.


RESULTS
The accuracy of this equation for differential diagnosis of TT and IDA was 86.82%. The sensitivity, specificity and Youden's index in prediction of TT and IDA were 94.29%, 79.66%, 73.9 and 76.92%, 90.52%, and 67.4%, respectively.


CONCLUSIONS
The stepwise regression equation using the red cell index is concise, rapid, and sensitive in differential diagnosis of TT and IDA, and can be well applicable in clinical practice.
Xie
You-ping
YP
Zhuhai Maternal and Child Health Care Hospital, Zhuhai 519001, China. zgxyp@163.com
Xiao
Qi-zhi
QZ
Zhou
Yu-qiu
YQ
Wu
Hong-qiu
HQ
Hu
Li-qing
LQ
D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D012044:Regression Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013789:Thalassemia / Q000097:blood / Q000175:diagnosis*