Tolperisone: a typical representative of a class of centrally acting muscle relaxants with less sedative side effects.
Tolperisone, a piperidine derivative, is assigned to the group of centrally acting muscle relaxants and has been in clinical use now for decades. The review summarizes the known pharmacokinetics, pharmacodynamics, toxicology and side effects in humans and the clinical use of tolperisone. A future perspective for further exploration of this drug is given.
Quasthoff
Stefan
S
Department for Neurology, Medical University of Graz, Austria.
Möckel
Claudia
C
Zieglgänsberger
Walter
W
Schreibmayer
Wolfgang
W
D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central / Q000009:adverse effects / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D014049:Tolperisone / Q000009:adverse effects / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity
D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central; D014049:Tolperisone