Spherical amyloid deposition in a prolactin-producing pituitary adenoma.
A 41-year-old man presented with headache, right-sided ophthalmic pain and visual deficit. His neurological examination was normal except for bitemporal hemianopsia and right lower quadranopsia. MRI demonstrated a mass arising from the pituitary gland. Hormonal analysis revealed an elevated prolactin level of 4700 ng/mL (normal 4.04-15.2 ng/mL). MRI revealed hypointense signal on T2-weighted images. Moreover, we also concluded that foci with no intravenous contrast enhancement represent the amyloid deposits. The patient underwent trans-sphenoidal resection of the pituitary adenoma. Histological examination revealed an adenoma with spheroid amyloid deposits adjacent to prolactin-staining adenoma cells. The patient recovered from the surgery without complications.
Gul
Sanser
S
Department of Neurosurgery, Zonguldak Karaelmas University Medical School, Zonguldak, Turkey. drsanser@yahoo.com
Bahadir
Burak
B
Dusak
Abdurrahim
A
Kalayci
Murat
M
Edebali
Nurullah
N
Acikgoz
Bektas
B
D000236:Adenoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000682:Amyloid / Q000378:metabolism*; D001718:Birefringence; D003224:Congo Red; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D010908:Pituitary Hormones, Anterior / Q000378:metabolism; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D011388:Prolactin / Q000378:metabolism
D000682:Amyloid; D010908:Pituitary Hormones, Anterior; D003224:Congo Red; D007633:Keratins; D011388:Prolactin