Templated synthesis of single-component polymer capsules and their application in drug delivery.
We report a general and facile approach for the fabrication of a new class of monodispersed, single-component and thick-walled polymer nanocapsules via the single-step assembly of macromolecules in solid core/mesoporous shell (SC/MS) silica particle templates, followed by cross-linking of the macromolecules and removal of the SC/MS templates. The general applicability of this approach is demonstrated by the preparation of nanocapsules using various polymers, including synthetic polyelectrolytes, polypeptides, and polypeptide-drug conjugates. The potential of doxorubicin (Dox)-loaded poly(L-glutamic acid) nanocapsules in tumor therapy applications is demonstrated via in vitro degradation experiments, which show a near-linear release of the Dox in the presence of a lysosomal hydrolase, nanocapsule uptake by human colorectal tumor cells, and delivery of the anticancer drug into the tumor cells, leading to tumor cell death.
Wang
Yajun
Y
Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, VIC, Australia.
Bansal
Vipul
V
Zelikin
Alexander N
AN
Caruso
Frank
F
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D002214:Capsules; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D011099:Polyglutamic Acid / Q000737:chemistry*
D000970:Antineoplastic Agents; D002214:Capsules; D004337:Drug Carriers; D011099:Polyglutamic Acid; D004317:Doxorubicin