title: A new entry to 1,5-keto esters and their 4,4-dideuterio derivatives via methylene chloride as "methylene dianion" equivalents.
abstract: This TiCl 4-Mg promoted multicomponent coupling of various amides with CH(2)Cl(2) and methyl acrylate represents an extremely simple and practical synthesis of 1,5-keto esters. The efficiency of this chemistry is illustrated by the very simple preparation of unusual 4,4-dideuterio-1,5-keto esters.
authors.affiliation: Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan, ROC.
authors.forename: Kuo-Wei
authors.initials: KW
authors.lastname: Lin
authors.forename: Cheng-Yih
authors.initials: CY
authors.lastname: Chen
authors.forename: Wei-Fan
authors.initials: WF
authors.lastname: Chen
authors.forename: Tu-Hsin
authors.initials: TH
authors.lastname: Yan