title: Complexes with biologically active ligands. Part 9 metal complexes of 5-benzoylamino- and 5-(3-nitrobenzoyl-amino)-1,3,4-thiadiazole-2-sulfonamide as carbonic anhydrase inhibitors.
abstract: Complexes containing the anions of 5-benzoylamido-1,3,4-thiadiazole-2-sulfonamide and 5-(3-nitro-benzoylamido)-1,3,4-thiadiazole-2-sulfonamid as ligands, and V(IV); Cr(III); Fe(III); Co(II); Ni(II); Cu(II) and Ag(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic, and EPR spectroscopy; TG, magnetic and conductimetric measurements). The original sulfonamides and their metal complexes are strong inhibitors of two carbonic anhydrase (CA) isozymes, CA I and II.
authors.affiliation: "I.G. Murgulescu" Institute of Physical Chemistry Spl. Independentei, 202 Bucharest R-77208 Romania.
authors.forename: A
authors.initials: A
authors.lastname: Jitianu
authors.forename: M A
authors.initials: MA
authors.lastname: Llies
authors.forename: F
authors.initials: F
authors.lastname: Briganti
authors.forename: A
authors.initials: A
authors.lastname: Scozzafava
authors.forename: C T
authors.initials: CT
authors.lastname: Supuran