title: Formation of enantiopure 5-substituted oxazolidinones through enzyme-catalysed kinetic resolution of epoxides.
abstract: Halohydrin dehalogenase from Agrobacterium radiobacter catalyzed the enantioselective ring opening of terminal epoxides with cyanate as a nucleophile, yielding 5-substituted oxazolidinones in high yields and with high enantiopurity (69-98% ee). This is the first example of the biocatalytic conversion of a range of epoxides to the corresponding oxazolidinones.
authors.affiliation: Ruder Bosković Institute, Zagreb, Croatia.
authors.forename: Maja Majerić
authors.initials: MM
authors.lastname: Elenkov
authors.forename: Lixia
authors.initials: L
authors.lastname: Tang
authors.forename: Auke
authors.initials: A
authors.lastname: Meetsma
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hauer
authors.forename: Dick B
authors.initials: DB
authors.lastname: Janssen
mesh_terms: D002384:Catalysis; D004852:Epoxy Compounds / Q000737:chemistry*; D006867:Hydrolases / Q000378:metabolism*; D007700:Kinetics; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry; D012231:Rhizobium / Q000201:enzymology*; D013237:Stereoisomerism
chemical_list: D004852:Epoxy Compounds; D023303:Oxazolidinones; D006867:Hydrolases; C430848:halohydrin dehalogenase