title: Anthelmintic acetogenin from Annona squamosa L. Seeds.
abstract: Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml(-1). The structure of 1 was determined as a C37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis.
authors.affiliation: Laboratório de Doenças Parasitárias, Universidade Estadual do Ceará, Fortaleza, CE, Brazil.
authors.forename: Marta M C
authors.initials: MM
authors.lastname: Souza
authors.forename: Claudia M L
authors.initials: CM
authors.lastname: Bevilaqua
authors.forename: Selene M
authors.initials: SM
authors.lastname: Morais
authors.forename: Cícero T C
authors.initials: CT
authors.lastname: Costa
authors.forename: Ana R A
authors.initials: AR
authors.lastname: Silva
authors.forename: Raimundo
authors.initials: R
authors.lastname: Braz-Filho
mesh_terms: D054378:Acetogenins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D031041:Annona / Q000737:chemistry*; D000871:Anthelmintics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006189:Haemonchus / Q000187:drug effects*; D010063:Ovum / Q000187:drug effects*; D021261:Parasitic Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D013057:Spectrum Analysis
chemical_list: D054378:Acetogenins; D000871:Anthelmintics; D010936:Plant Extracts