Metabolic comparison of radiolabeled aniline- and phenol-phthaleins with (131)I.
The metabolic comparison of aniline- and phenol-phthaleins radiolabeled with (131)I ((131)I-APH and (131)I-PPH, respectively) has been investigated in this study. To compare the metabolic behavior of these phthaleins and their glucuronide conjugates radiolabeled with (131)I, scintigraphic and biodistributional techniques were applied using male Albino rabbits. The results obtained have shown that these compounds were successfully radioiodinated with a radioiodination yield of about 100%. Maximum uptakes of (131)I-APH and (131)I-PPH, which were metabolized as N- and O-glucuronides, were observed within 2 h in the bladder and in the small intestine, respectively. In the case of verification of considerably up taking of these compounds also by tumors developed in the small intestine and in the bladder tissues, these results can be expected to be encouraging to test these compounds, which will be radiolabeled with other radioiodines such as (125)I, (123)I and (124)I as imaging and therapeutic agents in nuclear medical applications.
Avcibaşi
Uğur
U
Department of Chemistry, Faculty of Art and Science, Celal Bayar University, 45030 Manisa, Turkey. ugur.avcibasi@bayar.edu.tr
Avcibaşi
Nesibe
N
Unak
Turan
T
Unak
Perihan
P
Müftüler
Fazilet Zümrüt
FZ
Yildirim
Yeliz
Y
Dinçalp
Haluk
H
Gümüşer
Fikriye Gül
FG
Dursun
Ebru Rükşen
ER
D000814:Aniline Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D000818:Animals; D002853:Chromatography, Liquid; D020719:Glucuronides / Q000737:chemistry / Q000493:pharmacokinetics; D007414:Intestinal Neoplasms / Q000000981:diagnostic imaging*; D007421:Intestine, Small / Q000000981:diagnostic imaging / Q000473:pathology; D007457:Iodine Radioisotopes / Q000737:chemistry / Q000493:pharmacokinetics; D008297:Male; D013058:Mass Spectrometry; D020113:Phenolphthalein / Q000737:chemistry / Q000493:pharmacokinetics*; D011817:Rabbits; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D013053:Spectrophotometry; D014018:Tissue Distribution; D001743:Urinary Bladder / Q000000981:diagnostic imaging / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging*
D000814:Aniline Compounds; D020719:Glucuronides; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D020113:Phenolphthalein