title: Multiple ADH genes are associated with upper aerodigestive cancers.
abstract: Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: Mia
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authors.lastname: Hashibe
authors.forename: James D
authors.initials: JD
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authors.forename: Ana
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authors.lastname: Menezes
authors.forename: Marinel Mór
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authors.lastname: Dall'Agnol
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authors.lastname: Merletti
authors.forename: Lorenzo
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authors.lastname: Richiardi
authors.forename: Leticia
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authors.lastname: Fernandez
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authors.lastname: Lence
authors.forename: Renato
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authors.forename: Ioan Nicolae
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authors.forename: Kristina
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authors.forename: Gary J
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authors.lastname: Macfarlane
authors.forename: Tatiana V
authors.initials: TV
authors.lastname: Macfarlane
authors.forename: Lorenzo
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authors.lastname: Simonato
authors.forename: Cristina
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authors.lastname: Canova
authors.forename: Ivana
authors.initials: I
authors.lastname: Holcátová
authors.forename: Antonio
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authors.lastname: Agudo
authors.forename: Xavier
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authors.lastname: Castellsagué
authors.forename: Ray
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authors.lastname: Janout
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authors.lastname: Conway
authors.forename: Patricia A
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authors.lastname: McKinney
authors.forename: Ariana
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authors.lastname: Znaor
authors.forename: Eleonora
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authors.lastname: Fabianova
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authors.lastname: Bencko
authors.forename: Jolanta
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authors.lastname: Lissowska
authors.forename: Amelie
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authors.lastname: Chabrier
authors.forename: Rayjean J
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authors.lastname: Hung
authors.forename: Valerie
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authors.lastname: Gaborieau
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authors.lastname: Boffetta
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mesh_terms: D000328:Adult; D017677:Age Distribution; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000428:Alcohol Drinking; D020751:Alcohol-Induced Disorders / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C489332:ADH1B protein, human; C526911:ADH7 protein, human; D000426:Alcohol Dehydrogenase