A new method for the synthesis of H(4)-BINOL.
A method amenable to the gram scale synthesis of (R)-H 4-BINOL, a derivative of (R)-BINOL and ligand of interest in asymmetric catalysis, is described. The key step is the net partial hydrogenation of (R)-BINOL made possible by prior bis-etherification of the parent BINOL.
Heumann
Lars V
LV
Department of Chemistry, University of Utah, Salt Lake City, UT 84112-0850, USA.
Keck
Gary E
GE
D009682:Magnetic Resonance Spectroscopy; D009284:Naphthols / Q000138:chemical synthesis*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
C406944:BINOL, naphthol; D009284:Naphthols