title: Symptoms, supportive care needs, and function in cancer patients: how are they related?
abstract: OBJECTIVE
  To explore the associations among symptoms, supportive care needs, and function.
  
  
  METHODS
  One hundred and seventeen cancer patients completed the Supportive Care Needs Survey and EORTC-QLQ-C30 in a cross-sectional study. Associations among function (physical, role, emotional, cognitive, social), symptoms (fatigue, nausea/vomiting, pain, dyspnea, insomnia, appetite loss, constipation, diarrhea), and supportive care needs (physical and daily living, psychological, patient care and support, health system and information, sexual) were tested using multivariate item regression (MIR). We tested (1) function as the dependent variable with symptoms and supportive care needs as independent variables and (2) supportive care needs as the dependent variable with symptoms and function as independent variables.
  
  
  RESULTS
  Worse fatigue, pain, and appetite loss were associated with worse function. Greater unmet physical and daily living needs were associated with worse physical, role, and cognitive function. Greater unmet psychological needs were associated with worse emotional and cognitive function. Worse sleep problems were associated with greater unmet needs. Better physical function was associated with fewer unmet physical and daily living needs, and better emotional function was associated with fewer unmet psychological, patient care and support, and health system and information needs.
  
  
  CONCLUSIONS
  The results obtained with these models suggest several consistent relationships among symptoms, supportive care needs, and function.
authors.affiliation: Johns Hopkins School of Medicine, Baltimore, MD, USA. csnyder@jhsph.edu
authors.forename: Claire F
authors.initials: CF
authors.lastname: Snyder
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Garrett-Mayer
authors.forename: Julie R
authors.initials: JR
authors.lastname: Brahmer
authors.forename: Michael A
authors.initials: MA
authors.lastname: Carducci
authors.forename: Roberto
authors.initials: R
authors.lastname: Pili
authors.forename: Vered
authors.initials: V
authors.lastname: Stearns
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Wolff
authors.forename: Sydney M
authors.initials: SM
authors.lastname: Dy
authors.forename: Albert W
authors.initials: AW
authors.lastname: Wu
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006301:Health Services Needs and Demand; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000503:physiopathology*; D012944:Social Support