[Spontaneous regression of lung metastases from renal cell carcinoma: the importance of immunogenetic factors and a review of the literature].
Spontaneous regression of renal cell cancer (RCC) metastases most frequently occurs after nephrectomy, since reducing target size makes possible a more effective immune response. RCC is immunotherapy-sensitive, as are RCC metastases, especially metastases to the lungs (organs are rich in immune cells and continually exposed to antigens), which have an antigenic effect. Immunotherapy could be perfected if a renal antigen that could be incorporated into a vaccine were identified. This would have played an important role in treatment and follow-up. Vaccine therapy for RCC is no longer far out of reach. The characteristics of RCC make it a fertile field for the study of prometastatic and endogenous antiangiogenic factors.
Crisci
A
A
Dipartimento di Area Critica, Medico Chirurgica Urologia I, Università degli Studi di Firenze, viale Pieraccini 18, Florence, Italy. Alfonso.crisci@unifi.it
Corsale
I
I
Abrami
F
F
Politi
L
L
Andreani
M
M
Borgianni
S
S
Barale
D
D
Porfirio
B
B
D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000276:immunology / Q000556:secondary*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000235:genetics / Q000276:immunology / Q000556:secondary*; D009365:Neoplasm Regression, Spontaneous / Q000235:genetics / Q000276:immunology