Linkage of monogenic infantile hypertrophic pyloric stenosis to chromosome 16q24.
Infantile hypertrophic pyloric stenosis (IHPS) is the most common inherited form of gastrointestinal obstruction in infancy. The disease is considered a paradigm for the sex-modified model of multifactorial inheritance and affects males four times more frequently than females. However, extended pedigrees consistent with autosomal dominant inheritance have been documented. We have analysed data from an extended IHPS family including eight affected individuals (five males and three females) and mapped the disease locus to chromosome 16q24 (LOD score=3.7) through an SNP-based genome wide scan. Fourteen additional multiplex pedigrees did not show evidence of linkage to this region, indicating locus heterogeneity.
Everett
Kate V
KV
University College London Institute of Child Health, London, UK. kate.everett@ucl.ac.uk
Capon
Francesca
F
Georgoula
Christina
C
Chioza
Barry A
BA
Reece
Ashley
A
Jaswon
Mervyn
M
Pierro
Agostino
A
Puri
Prem
P
Gardiner
R Mark
RM
Chung
Eddie Mk
EM
D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D005260:Female; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D006801:Humans; D007223:Infant; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D010375:Pedigree; D046248:Pyloric Stenosis, Hypertrophic / Q000235:genetics*