title: Plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal circulation.
abstract: Leukocytosis and thrombocytopenia occur during cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC). Elevated circulating concentrations of macrophage colony-stimulating factor (M-CSF) are reported during thrombocytopenia and leukopenia of different origins. We have assessed M-CSF concentrations in 40 patients undergoing CPB with ECC. Plasma M-CSF concentrations were stable during ECC and increased at the 6th (7.3 +/- 0.7 IU/mug protein) and 24th (8.6 +/- 0.8 IU/mug protein) postoperative hour compared with pre-ECC values (4.9 +/- 0.5 IU/mug protein). A deep thrombocytopenia was found during ECC and until the 24th postoperative hour. A drop of leukocyte counts was found during ECC followed by an increase after ECC weaning. While no correlation was found between M-CSF concentrations and the leukocyte counts, M-CSF values were positively correlated with platelet counts only before and during ECC. Thus, M-CSF is not implicated in the thrombocytopenia and the leukopenia generated during CPB with ECC. However the elevated levels of M-CSFa few hours after the end of ECC might play a role in the inflammatory process often observed after CPB.
authors.affiliation: Department of Anaesthesia CHRU Dupuytren 2 Avenue Martin Luther King Limoges 87042 France.
authors.forename: Y
authors.initials: Y
authors.lastname: Denizot
authors.forename: P
authors.initials: P
authors.lastname: Fixe
authors.forename: E
authors.initials: E
authors.lastname: Cornu
authors.forename: N
authors.initials: N
authors.lastname: Nathan