title: Metabolic comparison of radiolabeled aniline- and phenol-phthaleins with (131)I.
abstract: The metabolic comparison of aniline- and phenol-phthaleins radiolabeled with (131)I ((131)I-APH and (131)I-PPH, respectively) has been investigated in this study. To compare the metabolic behavior of these phthaleins and their glucuronide conjugates radiolabeled with (131)I, scintigraphic and biodistributional techniques were applied using male Albino rabbits. The results obtained have shown that these compounds were successfully radioiodinated with a radioiodination yield of about 100%. Maximum uptakes of (131)I-APH and (131)I-PPH, which were metabolized as N- and O-glucuronides, were observed within 2 h in the bladder and in the small intestine, respectively. In the case of verification of considerably up taking of these compounds also by tumors developed in the small intestine and in the bladder tissues, these results can be expected to be encouraging to test these compounds, which will be radiolabeled with other radioiodines such as (125)I, (123)I and (124)I as imaging and therapeutic agents in nuclear medical applications.
authors.affiliation: Department of Chemistry, Faculty of Art and Science, Celal Bayar University, 45030 Manisa, Turkey. ugur.avcibasi@bayar.edu.tr
authors.forename: Uğur
authors.initials: U
authors.lastname: Avcibaşi
authors.forename: Nesibe
authors.initials: N
authors.lastname: Avcibaşi
authors.forename: Turan
authors.initials: T
authors.lastname: Unak
authors.forename: Perihan
authors.initials: P
authors.lastname: Unak
authors.forename: Fazilet Zümrüt
authors.initials: FZ
authors.lastname: Müftüler
authors.forename: Yeliz
authors.initials: Y
authors.lastname: Yildirim
authors.forename: Haluk
authors.initials: H
authors.lastname: Dinçalp
authors.forename: Fikriye Gül
authors.initials: FG
authors.lastname: Gümüşer
authors.forename: Ebru Rükşen
authors.initials: ER
authors.lastname: Dursun
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D000818:Animals; D002853:Chromatography, Liquid; D020719:Glucuronides / Q000737:chemistry / Q000493:pharmacokinetics; D007414:Intestinal Neoplasms / Q000000981:diagnostic imaging*; D007421:Intestine, Small / Q000000981:diagnostic imaging / Q000473:pathology; D007457:Iodine Radioisotopes / Q000737:chemistry / Q000493:pharmacokinetics; D008297:Male; D013058:Mass Spectrometry; D020113:Phenolphthalein / Q000737:chemistry / Q000493:pharmacokinetics*; D011817:Rabbits; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D013053:Spectrophotometry; D014018:Tissue Distribution; D001743:Urinary Bladder / Q000000981:diagnostic imaging / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D000814:Aniline Compounds; D020719:Glucuronides; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D020113:Phenolphthalein