New sulfoalkylresorcinol from marine-derived fungus, Zygosporium sp. KNC52.
A new sulfoalkylresorcinol (1) was isolated from the marine-derived fungus, Zygosporium sp. KNC52. The structure of 1 was elucidated by spectroscopic methods including MS and NMR, and the absolute stereochemistry was determined by the modified Mosher's method. Compound 1 inhibited FtsZ polymerization in vitro and exhibited weak antimicrobial activity against multi-drug-resistant bacteria.
Kanoh
Kaneo
K
Marine Biotechnology Institute Co., Ltd, Kamaishi, Iwate, Japan. kaneo.kanoh@mbio.jp
Adachi
Kyoko
K
Matsuda
Satoru
S
Shizuri
Yoshikazu
Y
Yasumoto
Ko
K
Kusumi
Takenori
T
Okumura
Kayo
K
Kirikae
Teruo
T
D001419:Bacteria / Q000187:drug effects; D001426:Bacterial Proteins / Q000737:chemistry; D003598:Cytoskeletal Proteins / Q000737:chemistry; D005658:Fungi / Q000737:chemistry / Q000378:metabolism*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D012118:Resorcinols / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment
D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; C071525:FtsZ protein, Bacteria; D007202:Indicators and Reagents; D012118:Resorcinols