title: In vivo anti-inflammatory effect of a new steroidal saponin, mannioside A, and its derivatives isolated from Dracaena mannii.
abstract: A new steroidal saponin, mannioside A (1), was isolated from the stem bark of Dracaena mannii, together with the known pennogenin (2), pennogenin-3-O-beta-D-glucopyranoside (3) and pennogenin-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->3)]-beta-D-glucopyranoside (4). Their structures were determined using 1D-and 2D-NMR spectroscopy and mass spectrometry. Compounds 1 and 3 significantly inhibited carrageenan-induced paw edema in the rat; compound 4 was moderately active whereas 2 showed very weak activity.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
authors.forename: Leon Azefack
authors.initials: LA
authors.lastname: Tapondjou
authors.forename: Kemvoufo Beaudelaire
authors.initials: KB
authors.lastname: Ponou
authors.forename: Remy Bertrand
authors.initials: RB
authors.lastname: Teponno
authors.forename: Marius
authors.initials: M
authors.lastname: Mbiantcha
authors.forename: Jules Désiré
authors.initials: JD
authors.lastname: Djoukeng
authors.forename: Télesphore Benoit
authors.initials: TB
authors.lastname: Nguelefack
authors.forename: Pierre
authors.initials: P
authors.lastname: Watcho
authors.forename: Aurelio Gomez
authors.initials: AG
authors.lastname: Cadenas
authors.forename: Hee-Juhn
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002351:Carrageenan; D031409:Dracaena; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D008297:Male; D008362:Mannosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008362:Mannosides; D010936:Plant Extracts; D012503:Saponins; C530810:pennogenin-3-O-rhamnopyranosyl-1-3-glucopyranoside; D002351:Carrageenan