title: G protein βγ subunits: central mediators of G protein-coupled receptor signaling.
abstract: G protein betagamma subunits are central participants in G protein-coupled receptor signaling pathways. They interact with receptors, G protein alpha subunits and downstream targets to coordinate multiple, different GPCR functions. Much is known about the biology of Gbetagamma subunits but mysteries remain. Here, we will review what is known about general aspects of structure and function of Gbetagamma as well as discuss emerging mechanisms for regulation of Gbetagamma signaling. Recent data suggest that Gbetagamma is a potential therapeutic drug target. Thus, a thorough understanding of the molecular and physiological functions of Gbetagamma has significant implications.
authors.affiliation: Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA. Alan_Smrcka@urmc.rochester.edu
authors.forename: A V
authors.initials: AV
authors.lastname: Smrcka
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D004353:Drug Evaluation, Preclinical; D044385:GTP-Binding Protein alpha Subunits / Q000737:chemistry / Q000378:metabolism*; D044388:GTP-Binding Protein gamma Subunits / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D046912:Multiprotein Complexes; D010449:Peptide Mapping; D037342:Pertussis Toxin / Q000633:toxicity; D025941:Protein Interaction Mapping; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D055672:Static Electricity
chemical_list: D044385:GTP-Binding Protein alpha Subunits; D044388:GTP-Binding Protein gamma Subunits; D046912:Multiprotein Complexes; D043562:Receptors, G-Protein-Coupled; D037342:Pertussis Toxin