A case of locked-in syndrome complicated by central deafness.
BACKGROUND
A 53-year-old male with a history of hypertension, diabetes mellitus, and factor V deficiency presented to an emergency room with progressively increasing headache, slurred speech, and left upper extremity weakness. Over the previous 3 months, he had been receiving warfarin for prophylaxis of deep venous thrombosis following knee surgery. After presentation and an initial period of coma, he became tetraplegic and anarthric, requiring intubation and ventilatory assistance.


METHODS
Neurological examination, CT scan, electroencephalogram, brainstem auditory and visual evoked potential studies, neuropsychological assessment and functional MRI studies.


METHODS
Locked-in syndrome following ventral pontine hemorrhage, complicated by central deafness secondary to extension of the lesion to the inferior colliculus.


RESULTS
Development of an augmentative communication system designed to exploit the patient's preserved cognitive and motor functions.
Smart
Colette M
CM
New Jersey Neuroscience Institute, JFK Medical Center, 65 James Street, Edison, NJ 08818, USA. csmart@solarishs.org
Giacino
Joseph T
JT
Cullen
Tara
T
Moreno
Diana Rodriguez
DR
Hirsch
Joy
J
Schiff
Nicholas D
ND
Gizzi
Martin
M
D002543:Cerebral Hemorrhage / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D006313:Hearing Loss, Central / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011149:Pons / Q000473:pathology; D011782:Quadriplegia / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy