Pleiotrophin induces expression of inflammatory cytokines in peripheral blood mononuclear cells.
Pleiotrophin (PTN) is a polypeptide that belongs to a family of heparin-binding growth factor, which displays mitogenic activity for a wide variety of cells. Since PTN induces the proliferation of immune cells the mechanism of action was investigated. In the present study, we show for the first time that PTN induces the expression of inflammatory cytokines including TNF-alpha, IL-1beta and IL-6 in quiescent human peripheral blood mononuclear cells (PBMC). These results emphasize the importance of PTN in the regulation of inflammatory processes. Elucidation of the mechanisms by which a host factor such PTN regulates cytokines production will significantly advance our understanding of endothelium-immunity interactions.
Achour
Ammar
A
Laboratoire des Interférons, UFR Biomédicale des Saint Pères, Université Paris Descartes, Paris, France. ammar.achour@univ-paris5.fr
M'bika
Jean Pierre
JP
Baudouin
Françoise
F
Caruelle
Danièle
D
Courty
José
J
D002352:Carrier Proteins / Q000494:pharmacology / Q000502:physiology*; D016207:Cytokines / Q000096:biosynthesis* / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D011994:Recombinant Proteins / Q000494:pharmacology
D002352:Carrier Proteins; D016207:Cytokines; D011994:Recombinant Proteins; C066845:pleiotrophin