title: Metastatic embryonal carcinoma in the maxillary gingiva.
abstract: Gingival metastases from embryonal carcinoma are very rare and often associated with widespread disease and poor prognosis. Because of their indistinct clinical appearance, they may be difficult to discriminate from more frequent gingival hyperplastic or reactive lesions. The case of a 35-year-old man who presented with a swelling in the left maxillary gingiva, extending from the first premolar to the second molar is reported. This medical history revealed that, 2 years previously, he had been diagnosed with a testicular mixed germ cell tumor (GCTs), for which he had undergone right inguinal orchidectomy and chemotherapy, leading to complete remission. Histology revealed a metastatic embryonal carcinoma. Imaging of the chest and abdomen showed this was the only site of metastasis. He is currently undergoing chemotherapy and responding well. This case draws attention to the multiple diseases that may present as gingival masses and stresses the difficulty of making a correct diagnosis. It is emphasized that in some mixed cases of testicular GCT it may be the more aggressive component that metastasizes, without being clearly apparent.
authors.affiliation: Università degli Studi di Milano-Bicocca, Facoltà di Medicina e Chirurgia Sezione Anatomia Patologica Ospedale San Gerardo, Monza, Italy. f.angiero@teos.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Angiero
authors.forename: Michele
authors.initials: M
authors.lastname: Stefani
mesh_terms: D000328:Adult; D018236:Carcinoma, Embryonal / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D003937:Diagnosis, Differential; D005887:Gingival Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018239:Seminoma / Q000175:diagnosis / Q000473:pathology / Q000556:secondary; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery