Proteomics in atherosclerosis.
Atherothrombosis is the underlying cause of several clinical manifestations, such as acute coronary syndromes, cerebrovascular disease, and peripheral artery disease, which together are the leading cause of death in the Western world. Proteins from vascular cells or atherosclerotic plaques that are present in plasma are modified along the different steps of atherosclerotic development and constitute target candidates for vascular research, particularly in the search for novel biological markers of cardiovascular risk. In this review, we summarize proteomic techniques and the most recent results obtained by application of these high-throughput strategies to cardiovascular samples.
Martinez-Pinna
Roxana
R
Vascular Research Laboratory, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040, Madrid, Spain.
Martin-Ventura
Jose Luis
JL
Mas
Sebastian
S
Blanco-Colio
Luis Maria
LM
Tuñon
Jose
J
Egido
Jesus
J
D000818:Animals; D050197:Atherosclerosis / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D015415:Biomarkers; D001792:Blood Platelets / Q000378:metabolism; D001808:Blood Vessels / Q000378:metabolism; D002853:Chromatography, Liquid; D015180:Electrophoresis, Gel, Two-Dimensional; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D051379:Mice; D011506:Proteins / Q000032:analysis; D040901:Proteomics / Q000379:methods*; D012307:Risk Factors; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D018629:Spectrometry, Mass, Secondary Ion
D015415:Biomarkers; D011506:Proteins