title: Liver cirrhosis, other liver diseases, and risk of hospitalisation for intracerebral haemorrhage: a Danish population-based case-control study.
abstract: BACKGROUND
  Liver diseases are suspected risk factors for intracerebral haemorrhage (ICH). We conducted a population-based case-control study to examine risk of ICH among hospitalised patients with liver cirrhosis and other liver diseases.
  
  
  METHODS
  We used data from the hospital discharge registries (1991-2003) and the Civil Registration System in Denmark, to identify 3,522 cases of first-time hospitalisation for ICH and 35,173 sex- and age-matched population controls. Among cases and controls we identified patients with a discharge diagnosis of liver cirrhosis or other liver diseases before the date of ICH. We computed odds ratios for ICH by conditional logistic regressions, adjusting for a number of confounding factors.
  
  
  RESULTS
  There was an increased risk of ICH for patients with alcoholic liver cirrhosis (adjusted OR = 4.8, 95% CI: 2.7-8.3), non-alcoholic liver cirrhosis (adjusted OR = 7.7, 95% CI: 2.0-28.9) and non-cirrhotic alcoholic liver disease (adjusted OR = 5.4, 95%CI:3.1-9.5) but not for patients with non-cirrhotic non-alcoholic liver diseases (adjusted OR = 0.9, 95%CI:0.5-1.6). The highest risk was found among women with liver cirrhosis (OR = 8.9, 95%CI:2.9-26.7) and for patients younger than 70 years (OR = 6.1, 95%CI:3.4-10.9). There were no sex- or age-related differences in the association between other liver diseases (alcoholic or non-alcoholic) and hospitalisation with ICH.
  
  
  CONCLUSIONS
  Patients with liver cirrhosis and non-cirrhotic alcoholic liver disease have a clearly increased risk for ICH.
authors.affiliation: Department of Medicine V, Aarhus University Hospital, Denmark. henning.gronbaek@dadlnet.dk
authors.forename: Henning
authors.initials: H
authors.lastname: Grønbaek
authors.forename: Søren P
authors.initials: SP
authors.lastname: Johnsen
authors.forename: Peter
authors.initials: P
authors.lastname: Jepsen
authors.forename: Mette
authors.initials: M
authors.lastname: Gislum
authors.forename: Hendrik
authors.initials: H
authors.lastname: Vilstrup
authors.forename: Ulrik
authors.initials: U
authors.lastname: Tage-Jensen
authors.forename: Henrik T
authors.initials: HT
authors.lastname: Sørensen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000209:etiology*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006753:Hospital Records; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000453:epidemiology; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications*; D008107:Liver Diseases / Q000150:complications* / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012042:Registries; D012307:Risk Factors