title: Comparison of the calculated and measured osmolality in intracranial bleeding and head injury patients.
abstract: Not all clinical laboratories have an osmometer, and calculations for osmolality are a frequently used method for determining osmolality. The purpose of this study was to evaluate the performance of four formulas for the estimation of osmolality, with cryoscopic measurement as the reference standard in intracranial hemorrhage (ICH) and head injury (HI) patients who were not treated with mannitol. Forty HI and 31 ICH patients treated in the Neurosurgery Department were included in the study. Every 6 h over a period of 24 h, serum samples were collected from patients and osmolality was measured. In conclusion, our study shows that only formulas F1 [Osmolality = 1.86(Na) + 1.86(K) + Glucose + Urea] and F4 [Osmolality = 1.86(Na) + Glucose + Urea + Ethanol + 9] can be used to evaluate osmolality in ICH patients who were not treated with mannitol. In HI patients, none of the formulas should be used to calculate osmolality.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey.
authors.forename: Serefden
authors.initials: S
authors.lastname: Açikgöz
authors.forename: Murat
authors.initials: M
authors.lastname: Can
authors.forename: A Görkem
authors.initials: AG
authors.lastname: Mungan
authors.forename: Meryem
authors.initials: M
authors.lastname: Ataymen
authors.forename: Vildan
authors.initials: V
authors.lastname: Sümbüloglu
authors.forename: Sanser
authors.initials: S
authors.lastname: Gül
mesh_terms: D000465:Algorithms; D001774:Blood Chemical Analysis / Q000379:methods; D004573:Electrolytes / Q000097:blood*; D016489:Head Injuries, Closed / Q000097:blood*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000097:blood*; D009994:Osmolar Concentration; D044366:Transition Temperature; D014882:Water-Electrolyte Balance
chemical_list: D004573:Electrolytes