title: Correlation of diffusion-weighted MRI with whole mount radical prostatectomy specimens.
abstract: The purpose of this study was to compare the apparent diffusion coefficient (ADC) of benign central gland (bCG), benign peripheral zone (bPZ) and cancer using diffusion-weighted MRI and whole mount specimens. 11 patients with biopsy-proven prostate cancer underwent diffusion-weighted MRI prior to radical prostatectomy. A single-shot echo planar image technique was used with b-values of 0 s mm(-2), 300 s mm(-2), 500 s mm(-2) and 800 s mm(-2). Whole mount specimens were compared with ADC maps. Areas of cancer, bCG and bPZ were identified, and regions of interest were drawn on ADC maps. Mean ADC values were recorded for all regions of interest, and paired t-tests were performed to compare mean values. Cancer was outlined in nine patients. In two patients, the tumours were too small to correlate with images; bCG was identified in 11 patients and bPZ was identified in 10 patients. Mean ADC values for bCG, bPZ and cancer were, 1.5 x 10(-3) mm(2) s(-1) (standard error (SE) = 0.04), 1.7 x 10(-3) mm(2) s(-1) (SE = 0.1), and 1.3 x 10(-3) mm(2) s(-1) (SE = 0.09), respectively. The most significant difference between benign tissue and cancer existed at b-values of 0-300 s mm(-2) (bCG vs cancer: mean difference = 0. 29, p = 0.001, 95% confidence interval (CI) = 0.17-0.41; bPZ vs cancer: mean difference = 0.34, p = 0.003, 95% CI = 0.18-0.61). In conclusion, we have confirmed, using whole mount verification, a significant difference in the ADC between benign tissue and cancer.
authors.affiliation: Academic Unit of Radiotherapy and Oncology, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK. Nicholas.vanas@rmh.nhs.uk
authors.forename: N
authors.initials: N
authors.lastname: Van As
authors.forename: E
authors.initials: E
authors.lastname: Charles-Edwards
authors.forename: A
authors.initials: A
authors.lastname: Jackson
authors.forename: S
authors.initials: S
authors.lastname: Jhavar
authors.forename: S
authors.initials: S
authors.lastname: Reinsberg
authors.forename: N
authors.initials: N
authors.lastname: Desouza
authors.forename: D
authors.initials: D
authors.lastname: Dearnaley
authors.forename: M
authors.initials: M
authors.lastname: Bailey
authors.forename: A
authors.initials: A
authors.lastname: Thompson
authors.forename: T
authors.initials: T
authors.lastname: Christmas
authors.forename: C
authors.initials: C
authors.lastname: Fisher
authors.forename: C
authors.initials: C
authors.lastname: Corbishley
authors.forename: S
authors.initials: S
authors.lastname: Sohaib
mesh_terms: D000328:Adult; D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000592:standards*; D017352:Echo-Planar Imaging / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies