Lipopolysaccharide-induced monocytic cell death for the diagnosis of mild neonatal-onset multisystem inflammatory disease.
In this report, we describe a boy who showed mild symptoms of neonatal-onset multisystem inflammatory disease. Although his symptoms and laboratory findings were similar to those of systemic juvenile idiopathic arthritis, further examinations revealed papilledema, meningitis, and a NLRP3 mutation. His peripheral blood monocytes died within 24 hours after lipopolysaccharide stimulation, a test that may be useful for diagnosis even in mild cases.
Takada
Hidetoshi
H
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. takadah@pediatr.med.kyushu-u.ac.jp
Ishimura
Masataka
M
Inada
Hiroko
H
Ohga
Shouichi
S
Kusuhara
Koichi
K
Moroi
Yoichi
Y
Furue
Masutaka
M
Hara
Toshiro
T
D016923:Cell Death; D002648:Child; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D009000:Monocytes / Q000187:drug effects*; D012720:Severity of Illness Index
D008070:Lipopolysaccharides