Effect of oxybutynin on exercise-induced sweating in healthy individuals.
OBJECTIVE
Oxybutynin has been proven to be effective in patients with generalized hyperhidrosis. Some dermatoses aggravate as a result of sweating. Therefore, oxybutynin might also be useful in such normohidrotic patients. The aim was to evaluate the efficacy and safety of different doses of oxybutynin on exercise-induced sweating in healthy individuals.


METHODS
Two randomized, double-blind, placebo-controlled, cross-over studies were performed, in which two different dosages (2.5 and 5 mg) of oxybutynin were tested. The degree of sweating was determined by transepidermal water loss (TEWL) measurement on the forearm and the hand during exercise. Furthermore, the effectiveness was evaluated by means of the individual's global assessment score, and side effects were noted.


RESULTS
No significant differences between oxybutynin and placebo were found on the forearm and the hand at both dosages of oxybutynin with respect to TEWL values and the individual's global assessment score. Side effects consisted of diarrhoea, dizziness, dry mouth and dry eyes.


CONCLUSIONS
In this model, oxybutynin did not result in inhibition of exercise-induced sweating in healthy volunteers.
van Houte
Marthe
M
Department of Dermatology, St. Antonius Hospital, Nieuwegein, The Netherlands.
Harmsze
Ankie M
AM
Deneer
Vera H M
VH
Tupker
Ron A
RA
D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008333:Mandelic Acids / Q000494:pharmacology*; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D012016:Reference Values; D013546:Sweating / Q000187:drug effects*
D008333:Mandelic Acids; D018727:Muscarinic Antagonists; C005419:oxybutynin