title: Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus.
abstract: The utility of measuring the corpus callosal angle (CA) for the diagnosis of idiopathic normal pressure hydrocephalus (INPH) was investigated. Three-dimensional magnetic resonance imaging (MRI) was performed in 34 INPH patients, 34 Alzheimer's disease (AD) patients, and 34 normal control (NC) subjects. Measurement of the CA on the coronal MR images of the posterior commissure perpendicular to the anteroposterior commissure plane was performed for all subjects. The CA of the INPH group (mean +/- SD, 66 +/- 14 degrees) was significantly smaller than those of the AD (104 +/- 15 degrees) and NC (112 +/- 11 degrees) groups. When using the threshold of the mean - 2SD value of the NC group (= 90 degrees), an accuracy of 93%, sensitivity of 97%, and specificity of 88% were observed for discrimination of INPH from AD patients. Measuring the CA helps in differentiating INPH patients from AD and normally aged subjects.
authors.affiliation: Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, Himeji, Hyogo, Japan. kishii@hbhc.jp
authors.forename: Kazunari
authors.initials: K
authors.lastname: Ishii
authors.forename: Tomonori
authors.initials: T
authors.lastname: Kanda
authors.forename: Aya
authors.initials: A
authors.lastname: Harada
authors.forename: Naokazu
authors.initials: N
authors.lastname: Miyamoto
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Shimada
authors.forename: Shingo
authors.initials: S
authors.lastname: Ohkawa
authors.forename: Takafumi
authors.initials: T
authors.lastname: Uemura
authors.forename: Toshiki
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Etsuro
authors.initials: E
authors.lastname: Mori
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000175:diagnosis*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity