title: Population data and mutation rate of nine Y-STRs in a mestizo Mexican population from Guadalajara, Jalisco, México.
abstract: Nine Y-STR (DYS19, DYS390, DYS391, DYS392, DYS446, DYS447, DYS448, DYS456 and DYS458) were analyzed in a male sample of 285 unrelated individuals from Guadalajara, Jalisco, México. The haplotype diversity (0.996) and discrimination capacity (0.986) were calculated. A family study of around 200 father/son pairs and among 1828 meiosis showed five mutational events. All mutations were single step. The overall mutation rate estimated across the nine Y-STRs was 2.7 x 10(-3) (95% CI 1.2-6.4 x 10(-3))/locus/meiosis. The results indicate that these nine loci are useful Y-linked markers for forensic applications.
authors.affiliation: Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada 800, Colonia Independencia, Guadalajara, Jalisco 44340, Mexico. imey_99@yahoo.com
authors.forename: Jorge Ramón
authors.initials: JR
authors.lastname: Padilla-Gutiérrez
authors.forename: Yeminia
authors.initials: Y
authors.lastname: Valle
authors.forename: Antonio
authors.initials: A
authors.lastname: Quintero-Ramos
authors.forename: Guillermo
authors.initials: G
authors.lastname: Hernández
authors.forename: Katya
authors.initials: K
authors.lastname: Rodarte
authors.forename: Rocío
authors.initials: R
authors.lastname: Ortiz
authors.forename: Norma
authors.initials: N
authors.lastname: Olivares
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivas
mesh_terms: D041322:Chromosomes, Human, Y / Q000235:genetics*; D004252:DNA Mutational Analysis; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D008297:Male; D008800:Mexico / Q000208:ethnology; D018895:Microsatellite Repeats / Q000235:genetics*