title: Synthesis and cytotoxicity of silicon containing pyridine and quinoline sulfides.
abstract: Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. Aliphatic silicon derivatives were considerably less active. 8-[(Trimethylsilylmethyl)thio]quinoline (8a) exhibits the highest activity among quinoline sulfides.
authors.affiliation: Latvian Institute of Organic Synthesis 21 Aizkraukles Street Riga LV-I006 Latvia.
authors.forename: Edmunds
authors.initials: E
authors.lastname: Lukevics
authors.forename: Edgars
authors.initials: E
authors.lastname: Abele
authors.forename: Pavel
authors.initials: P
authors.lastname: Arsenyan
authors.forename: Ramona
authors.initials: R
authors.lastname: Abele
authors.forename: Kira
authors.initials: K
authors.lastname: Rubina
authors.forename: Irina
authors.initials: I
authors.lastname: Shestakova
authors.forename: Ilona
authors.initials: I
authors.lastname: Domracheva
authors.forename: Violetta
authors.initials: V
authors.lastname: Vologdina