title: Familial clustering of parotid gland lymphoepithelioma in North America.
abstract: OBJECTIVE
  To describe genetic susceptibility in the first familial clustering of parotid gland lymphoepithelioma reported in North America.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Tertiary care institution with outreach to northern Quebec.
  
  
  METHODS
  Chart, family history, literature review, and c-kit assay.
  
  
  METHODS
  C-kit assay.
  
  
  RESULTS
  Four family members of both sexes over two generations had lymphoepithelioma of the parotid gland, without involvement of the nasopharynx. Two c-kit assays were positive of the three cases that could be done. Association with Epstein-Barr virus has been demonstrated in the oncogenesis of lymphoepithelioma.
  
  
  CONCLUSIONS
  Genetic susceptibility and common familial environmental factors play a role in the development of parotid gland lymphoepithelioma. A complete family history should be obtained in all cases of lymphoepithelioma of the parotid gland.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Royal Victoria Hospital, McGill University, Montreal, Quebec.
authors.forename: Thien-Tuong-Vi
authors.initials: TT
authors.lastname: Vu
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Zeitouni
authors.forename: Pantelis
authors.initials: P
authors.lastname: Tsinalis
authors.forename: William D
authors.initials: WD
authors.lastname: Foulkes
authors.forename: Abdulrahman
authors.initials: A
authors.lastname: Hagr
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000235:genetics* / Q000473:pathology; D011792:Quebec; D012189:Retrospective Studies