title: [Changes and clinical significance of serum Apelin in patients with severe sepsis and septic shock].
abstract: OBJECTIVE
  To explore the changes and clinical significance of serum Apelin in patients with severe sepsis and septic shock.
  
  
  METHODS
  We measured the serum level of Apelin with ELISA on different observation days (the 1st, 3rd, and 10th day obtaining the diagnosis) in 26 patients with severe sepsis and septic shock.
  
  
  RESULTS
  Serum Apelin significantly increased in sepsis patients when compared with the normal control group (P<0.01); The serum Apelin levels significantly changed among different observation days (P< 0.01). Serum Apelin level was significantly higher in patients with septic shock than those with severe sepsis (P<0.01).
  
  
  CONCLUSIONS
  Serum Apelin level changes in patients with severe sepsis and septic shock, which may provide clues in diagnosis and prognosis.
authors.affiliation: Department of Emergency Medicine, Institute on Cardiovascular Disease Research, Peking University First Hospital, Beijing 100034, China. chenxuyan@medmail.com.cn
authors.forename: Xu-Yan
authors.initials: XY
authors.lastname: Chen
authors.forename: Xin-Min
authors.initials: XM
authors.lastname: Liu
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Feng
authors.forename: Chao-Shu
authors.initials: CS
authors.lastname: Tang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000073861:Apelin; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000097:blood* / Q000401:mortality / Q000473:pathology; D012772:Shock, Septic / Q000097:blood* / Q000401:mortality / Q000473:pathology; D013997:Time Factors
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins