Filaggrin mutations and allergic contact sensitization.
In this issue, Novak et al. (2008) provide evidence that filaggrin barrier defects might also predispose to allergic contact dermatitis by allowing greater penetration of chemical haptens. Their report provides a fresh perspective on the issues of contact allergy, nickel sensitization, and stratum corneum defects.
Hanifin
Jon M
JM
Department of Dermatology, Oregon Health and Science University, Center for Health and Healing, Portland, Oregon 97239, USA. hanifinj@ohsu.edu
D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000235:genetics*; D003876:Dermatitis, Atopic; D004485:Eczema / Q000473:pathology; D000091344:Filaggrin Proteins; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D006969:Hypersensitivity, Immediate; D007249:Inflammation; D007381:Intermediate Filament Proteins / Q000235:genetics*; D008954:Models, Biological; D009154:Mutation; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology*; D010328:Patch Tests; D012867:Skin / Q000276:immunology / Q000473:pathology
C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D009532:Nickel