ATP1A2 gene mutations are not present in two sisters with basilar-type migraine associated with menses.
Basilar-type migraine (BM) and hemiplegic migraine are clinically distinct subtypes of migraine with aura, however they do share clinical features and it is possible they may share genetic bases. In recent years, ATP1A2 and other gene mutations have been discovered in familial and sporadic hemiplegic migraine. More recently, an ATP1A2 mutation has been identified in an Italian family with BM. In this study we document the absence of ATP1A2 mutations in two Italian sisters with menstrual BM, suggesting that other genes are involved in the condition.
Cologno
Daniela
D
Institute of Clinical Neurophysiology Department of Neuroscience, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Foggia, Italy. danielacologno@virgilio.it
d'Onofrio
Florindo
F
Esposito
Teresa
T
Gianfrancesco
Fernando
F
Petretta
Vittorio
V
Casucci
Gerardo
G
Frediani
Fabio
F
Buzzi
Maria Gabriella
MG
Bussone
Gennaro
G
D000328:Adult; D004252:DNA Mutational Analysis; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007558:Italy; D008598:Menstruation; D020325:Migraine with Aura / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D009154:Mutation / Q000235:genetics*; D035781:Siblings; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics*
D005819:Genetic Markers; C498531:ATP1A2 protein, human; D000254:Sodium-Potassium-Exchanging ATPase