[Cardioprotective efficacy of dinitrosyl iron complex with L-cysteine in rats in vivo].
The effect ofdinitrosyl iron complex (DNIC) with L-cysteine on the hemodynamic indices and the size of myocardial infarction, which was induced by 40-min regional ischemia and subsequent 60-min reperfusion, have been studied in rats in vivo. Intravenous bolus injection of DNIC (3.1 micromol/kg body weight in 0.5 ml saline) was performed before regional ischemia; the control group was administered the same volume of saline. DNIC administration significantly decreased the mean blood pressure throughout the experiment. DNIC reduced the duration of cardiac arrhythmias to 170 +/- 10 s as against 445 +/- 30 s in control. The myocardial infraction size significantly decreased in the DNIC group compared to control (38.0 +/- 1.4 and 48.0 +/- 3.9% of the area at risk, respectively; p < 0.05). A combination of the vasodilatory effect of DNIC with the reduction of the damaging effect of cardiac ischemia and reperfusion encourage the development of hypotensive and antiischemic drugs on this class of NO donors.
Pisarenko
O I
OI
Serebriakova
L I
LI
Tskitishvili
O V
OV
Studneva
I M
IM
Vanin
A F
AF
Chazov
E I
EI
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D020030:Nitric Oxide Donors / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D020030:Nitric Oxide Donors; C072081:dinitrosyl-iron(II)-cysteine; D003545:Cysteine