Comparison of serum adiponectin and tumor necrosis factor-alpha levels between patients with and without obstructive sleep apnea syndrome.
BACKGROUND
The obstructive sleep apnea syndrome (OSAS) is closely associated with cardiovascular and metabolic disorders.


OBJECTIVE
The aim of this study was to evaluate the influence of OSAS on plasma adiponectin levels independent of obesity in our study group. We also investigated the association between plasma adiponectin, plasma tumor necrosis factor-alpha (TNF-alpha), obesity, cardiovascular disease (CVD) and OSAS.


METHODS
The patients were classified into controls or OSAS patients according to the apnea-hypopnea index (AHI): patients with an AHI <5 constituted the control group (n = 32) and patients with an AHI > or =5 constituted the OSAS group (n = 106). Plasma TNF-alpha and adiponectin levels were measured in both groups.


RESULTS
Plasma adiponectin levels were negatively correlated with AHI, body mass index (BMI) and SpO(2) <90% and positively correlated with minimum oxygen saturation. The plasma levels of TNF-alpha were positively correlated with SpO(2) <90%, BMI and fasting plasma glucose levels. In addition, there was a significant negative correlation between plasma TNF-alpha and adiponectin levels in theOSAS group. Compared with thenon-obese OSAS group, subjects with obesity and OSAS had lower adiponectin levels and SpO(2) <90%, and higher TNF-alpha levels. Obese OSAS patients had higher rates of CVD with lower plasma adiponectin levels when compared with obese control subjects.


CONCLUSIONS
Serum adiponectin is significantly lower in patients with OSAS and it is independent of obesity. This might explain the high incidence of CVD and metabolic syndrome in patients with OSAS.
Kanbay
Asiye
A
Department of Pulmonary Medicine, Gazi University School of Medicine, Ankara, Turkey. kanbaydr@yahoo.com
Kokturk
Oguz
O
Ciftci
Tansu Ulukavak
TU
Tavil
Yusuf
Y
Bukan
Neslihan
N
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D010100:Oxygen / Q000097:blood; D020181:Sleep Apnea, Obstructive / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D052242:Adiponectin; D001786:Blood Glucose; D014409:Tumor Necrosis Factor-alpha; D010100:Oxygen