Is p190 bcr-abl rearrangement necessary for acute transformation in some p210 CML of childhood?
Chronic myeloid leukemia (CML) is a rare disease in childhood which is almost exclusively associated with bcr-abl p210 (M-bcr) rearrangements. It has been suggested that co-expression of p190 and p210 may be a pathway of CML progression in adult patients. We report two cases of pediatric patients with a diagnosis of CML who presented co-expression of the p210 and p190 transcripts during progression to the blastic phase. The present data suggest that p190 may be a secondary event in at least some cases of childhood CML, suggesting an association with progression to a blastic crisis in these patients.
Scrideli
Carlos Alberto
CA
Department of Pediatrics, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto (SP), Brazil.
de Oliveira
Fábio Morato
FM
Brassesco
Maria Sol
MS
de Paula Queiroz
Rosane
R
Bernardes
José Eduardo
JE
Valera
Elvis Terci
ET
Tone
Luiz Gonzaga
LG
D001752:Blast Crisis; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D012334:RNA, Neoplasm / Q000032:analysis
D012334:RNA, Neoplasm; D016044:Fusion Proteins, bcr-abl