title: Organocatalytic enantioselective domino Michael-aldol condensation of 5-oxoalkanal and alpha,beta-unsaturated aldehydes. Efficient assembly of densely functionalized cyclohexenes.
abstract: Organocatalytic Michael reaction of glutaraldehyde and 3-arylpropenal followed by the subsequent intramolecular aldol condensation provided 2-arylcyclohex-3-ene-1,3-dicarbaldehydes. Reactions with the 5-oxohexanal variant afforded the highly functionalized cyclohexenedicarbaldehydes in high diastereoselectivity and high enantioselectivity (>99% ee). Structure of the adduct 3j was confirmed unambiguously by X-ray analysis.
authors.affiliation: Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, Taiwan, ROC. chebch@ccu.edu.tw
authors.forename: Bor-Cherng
authors.initials: BC
authors.lastname: Hong
authors.forename: Roshan Y
authors.initials: RY
authors.lastname: Nimje
authors.forename: Amit A
authors.initials: AA
authors.lastname: Sadani
authors.forename: Ju-Hsiou
authors.initials: JH
authors.lastname: Liao