Sesquiterpenes from aerial parts of Ferula vesceritensis.
From the dichloromethane extract of aerial parts of Ferula vesceritensis (Apiaceae), 11 sesquiterpene derivatives were isolated. Among them five were compounds designated as 10-hydroxylancerodiol-6-anisate, 2,10-diacetyl-8-hydroxyferutriol-6-anisate, 10-hydroxylancerodiol-6-benzoate, vesceritenone and epoxy-vesceritenol. The six known compounds were identified as feselol, farnesiferol A, lapidol, 2-acetyl-jaeschkeanadiol-6-anisate, lasidiol-10-anisate and 10-oxo-jaesckeanadiol-6-anisate. All the structures were determined by extensive spectroscopic studies including 1D and 2D NMR experiments and mass spectroscopy analysis. Two of the compounds, the sesquiterpene coumarins farnesiferol A and feselol, bound to the model recombinant nucleotide-binding site of an MDR-like efflux pump from the enteropathogenic protozoan Cryptosporidium parvum.
Oughlissi-Dehak
Karima
K
Université de Lyon, UMR 5557 CNRS, Département de Pharmacognosie, Botanique et Phytothérapie, Faculté de Pharmacie, 8 Avenue Rockefeller, 69373 Lyon Cedex 08, France.
Lawton
Philippe
P
Michalet
Serge
S
Bayet
Christine
C
Darbour
Nicole
N
Hadj-Mahammed
Mahfoud
M
Badjah-Hadj-Ahmed
Yacine A
YA
Dijoux-Franca
Marie-Geneviève
MG
Guilet
David
D
D005309:Ferula / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry*
D012717:Sesquiterpenes