title: Poised RNA polymerase II gives pause for thought.
abstract: Transcription by RNA polymerase II (Pol II) is thought to be predominantly regulated by recruitment of Pol II to promoters. Recent genome-wide analyses demonstrate that many genes are in fact regulated after recruitment of Pol II, by mechanisms such as pausing of Pol II proximal to promoters.
authors.affiliation: Department of Physiological Chemistry, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
authors.forename: Thanasis
authors.initials: T
authors.lastname: Margaritis
authors.forename: Frank C P
authors.initials: FC
authors.lastname: Holstege
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D008957:Models, Genetic; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D012319:RNA Polymerase II