Hemophagocytic syndrome associated with hepatitis A: case report and literature review.
Virus-Associated Hemophagocytic Syndrome (VAHS) is a severe hematological disorder related to some viral infections. It is an illness characterized by persistent fever, pancytopenia, splenomegaly, hyperferritinemia and, the most important, hemophagocytosis observed in the bone marrow, liver and/or lymph nodes. VAHS associated with hepatitis A virus infection is rarely described, despite the high incidence of this viral infection in the population in general. There is no consensus in the literature regarding the optimal treatment of VAHS. In this article the clinical features, presumed pathogenesis, diagnostic criteria and treatment of VAHS are discussed, including description of cases of VAHS related to hepatitis A virus infection found in the medical literature.
Tuon
Felipe Francisco
FF
Department of Infectious and Parasitic Diseases, University of São Paulo Medical School, São Paulo, SP, Brazil.
Gomes
Virginia Soares
VS
Amato
Valdir Sabbaga
VS
Graf
Maria Esther
ME
Fonseca
Guilherme Henrique Hencklain
GH
Lazari
Carolina
C
Nicodemo
Antonio Carlos
AC
D000328:Adult; D005260:Female; D006506:Hepatitis A / Q000150:complications* / Q000175:diagnosis; D035922:Hepatitis A Antibodies / Q000097:blood; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*
D035922:Hepatitis A Antibodies; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors