title: Captopril-induced lichen planus pemphigoides.
abstract: OBJECTIVE
  To report a rare case of lichen planus pemphigoides (LPP) possibly induced by captopril.
  
  
  METHODS
  A 74-year-old woman developed pruriginous and bullous lichenoid eruption after starting captopril for hypertension. Histopathological and immunological features were consistent with the diagnosis of LPP that was managed by discontinuing captopril and corticosteroid therapy. Eight months after the cessation of oral steroid therapy, no relapse had occurred.
  
  
  CONCLUSIONS
  LPP, a rare skin disorder, has been generally considered to represent a mixture of clinical, histopathological and immunological patterns of lichen planus and bullous pemphigoid. It is predominantly idiopathic. However, in rare cases it has been associated with the administration of drugs. Here we present a typical LPP related to the use of captopril.
  
  
  CONCLUSIONS
  Clinicians should be aware of the ability of captopril to induce LPP.
authors.affiliation: Department of Clinical Pharmacology, Faculty of Medicine of Sousse, Tunisia.
authors.forename: Chaker
authors.initials: C
authors.lastname: Ben Salem
authors.forename: Lilia
authors.initials: L
authors.lastname: Chenguel
authors.forename: Najet
authors.initials: N
authors.lastname: Ghariani
authors.forename: Mohamed
authors.initials: M
authors.lastname: Denguezli
authors.forename: Houssem
authors.initials: H
authors.lastname: Hmouda
authors.forename: Kamel
authors.initials: K
authors.lastname: Bouraoui
mesh_terms: D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D002216:Captopril / Q000009:adverse effects*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008010:Lichen Planus / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D010391:Pemphigoid, Bullous / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D005938:Glucocorticoids; D002216:Captopril