[Risk factors of preeclampsia in single pregnancy].
OBJECTIVE
Study of the clinical risk factors of preeclampsia during a single pregnancy.


METHODS
Retrospective case-control study during five years.


RESULTS
One hundred and eighty-eight cases of preeclampsia have been studied, with 147 called severe (78.2%). We find as risk factors: first pregnancy (OR=2.11; IC 95% [1.30-3.35]), primiparity (OR=2.67; IC 95% [1.67-4.29]), primipaternity (OR=3.55; IC 95% [2.13-5.83], maternal overweight (OR=2.50; IC 95% [1.55-4.05]), personal history of preeclampsia (OR=8.12; IC 95% [2.37-45.65]), personal history of hypertension (OR=2.77; IC 95% [1.01-7.99]), familial history of preeclampsia (OR=1.04; IC 95% [1.01-1.08]), familial history of hypertension at the first step (OR=2.61; IC 95% [1.32-5.47]). Two elements have been found as protected: tobacco before pregnancy (OR=0.51; IC 95% [0.36-0.85]), tobacco during pregnancy (OR=0.52; IC 95% [0.30-0.92]).


CONCLUSIONS
Preeclampsia is responsible of a high maternal and fetal morbidity. The risk factors are widespread, the only use of them is not enough to determine the individual risk. A second step could be to determine if biological markers are better than clinical factors.
Merviel
P
P
Service de gynécologie-obstétrique et médecine de la reproduction, CHU d'Amiens, 124, rue Camille-Desmoulins, 80054 Amiens cedex 1, France. Merviel.Philippe@chu-amiens.fr
Touzart
L
L
Deslandes
V
V
Delmas
M
M
Coicaud
M
M
Gondry
J
J
D016022:Case-Control Studies; D005260:Female; D005602:France; D020073:Gravidity; D006801:Humans; D006973:Hypertension / Q000150:complications; D008487:Medical History Taking; D050177:Overweight / Q000150:complications; D010298:Parity; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects