title: Common sequence variants on 20q11.22 confer melanoma susceptibility.
abstract: We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.
authors.affiliation: Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85028, USA.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Brown
authors.forename: Stuart
authors.initials: S
authors.lastname: Macgregor
authors.forename: Grant W
authors.initials: GW
authors.lastname: Montgomery
authors.forename: David W
authors.initials: DW
authors.lastname: Craig
authors.forename: Zhen Zhen
authors.initials: ZZ
authors.lastname: Zhao
authors.forename: Kelly
authors.initials: K
authors.lastname: Iyadurai
authors.forename: Anjali K
authors.initials: AK
authors.lastname: Henders
authors.forename: Nils
authors.initials: N
authors.lastname: Homer
authors.forename: Megan J
authors.initials: MJ
authors.lastname: Campbell
authors.forename: Mitchell
authors.initials: M
authors.lastname: Stark
authors.forename: Shane
authors.initials: S
authors.lastname: Thomas
authors.forename: Helen
authors.initials: H
authors.lastname: Schmid
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Holland
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Gillanders
authors.forename: David L
authors.initials: DL
authors.lastname: Duffy
authors.forename: Judith A
authors.initials: JA
authors.lastname: Maskiell
authors.forename: Jodie
authors.initials: J
authors.lastname: Jetann
authors.forename: Megan
authors.initials: M
authors.lastname: Ferguson
authors.forename: Dietrich A
authors.initials: DA
authors.lastname: Stephan
authors.forename: Anne E
authors.initials: AE
authors.lastname: Cust
authors.forename: David
authors.initials: D
authors.lastname: Whiteman
authors.forename: Adele
authors.initials: A
authors.lastname: Green
authors.forename: Håkan
authors.initials: H
authors.lastname: Olsson
authors.forename: Susana
authors.initials: S
authors.lastname: Puig
authors.forename: Paola
authors.initials: P
authors.lastname: Ghiorzo
authors.forename: Johan
authors.initials: J
authors.lastname: Hansson
authors.forename: Florence
authors.initials: F
authors.lastname: Demenais
authors.forename: Alisa M
authors.initials: AM
authors.lastname: Goldstein
authors.forename: Nelleke A
authors.initials: NA
authors.lastname: Gruis
authors.forename: David E
authors.initials: DE
authors.lastname: Elder
authors.forename: Julia Newton
authors.initials: JN
authors.lastname: Bishop
authors.forename: Richard F
authors.initials: RF
authors.lastname: Kefford
authors.forename: Graham G
authors.initials: GG
authors.lastname: Giles
authors.forename: Bruce K
authors.initials: BK
authors.lastname: Armstrong
authors.forename: Joanne F
authors.initials: JF
authors.lastname: Aitken
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Trent
authors.forename: Graham J
authors.initials: GJ
authors.lastname: Mann
authors.forename: Nicholas K
authors.initials: NK
authors.lastname: Hayward
mesh_terms: D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D002890:Chromosomes, Human, Pair 20; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008545:Melanoma / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012878:Skin Neoplasms / Q000235:genetics*