[Clinical analyses of 70 cases of multiple primary colorectal carcinoma].
OBJECTIVE
Multiple primary colorectal carcinoma (MPCC) is not rarely seen, but it possesses a unique biological characters. This study was to investigate the clinical characteristics, diagnosis, therapeutic principle and prognosis of MPCC.


METHODS
Data of 70 MPCC patients, treated by operation from 1997 to 2003, were analyzed. Of the 70 patients, 61 had synchronous carcinoma (SC) and 9 had metachronous carcinoma (MC).


RESULTS
Fifty-five patients were diagnosed by colonoscopy, barium enema or CT scan pre-operationally, while 15 were diagnosed intra-operationally due to the oversized tumor at the distal end of the colon. Thirty-three patients had colorectal carcinoma accompanying with adenoma and multiple polyps. All the patients underwent surgical resection except 3, who received short-circuit operation because of unresectable lesions. Fifty-two patients received radical resection, while 15 received palliative resection due to hepatic or peritoneal metastasis. The overall 3-and 5-year survival rates were 65.7% and 45.7%. In the patients who received radical resection, the 3-and 5-year survival rates were 78.1% and 59.3%.


CONCLUSIONS
The occurrence of MPCC is largely related with adenomas and polyps. The extent of resection should be individually determined by the lesion location, range, the distance of lesions as well as the general condition of the patients. Prognosis of MPCC is relatively good. The patients accompanying with adenoma and multiple polyps should be followed up intensively.
Wang
Wei
W
State Key Labortary of Oncology in South China, Guangzhou, Guangdong, 510060, People's Republic of China.
Zhou
Zhi-Wei
ZW
Wan
De-Sen
DS
Lu
Zhen-Hai
ZH
Chen
Gong
G
Pan
Zhi-Zhong
ZZ
Li
Li-Ren
LR
Wu
Xiao-Jun
XJ
Ding
Pei-Rong
PR
D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D000231:Adenocarcinoma, Papillary / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D044584:Carcinoma, Ductal / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D003082:Colectomy / Q000379:methods*; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D012007:Rectum / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate