title: Influence of hydrophobic mismatching on membrane protein diffusion.
abstract: The observation of membrane domains in vivo and in vitro has triggered a renewed interest in the size-dependent diffusion of membrane inclusions (e.g., clusters of transmembrane proteins and lipid rafts). Here, we have used coarse-grained membrane simulations to quantify the influence of a hydrophobic mismatch between the inclusion's transmembrane portion and the surrounding lipid bilayer on the diffusive mobility of the inclusion. Our data indicate only slight changes in the mobility (<30%) when altering the hydrophobic mismatch, and the scaling of the diffusion coefficient D is most consistent with previous hydrodynamic predictions, i.e., with the Saffman-Delbruck relation and the edgewise motion of a thin disk in the limit of small and large radii, respectively.
authors.affiliation: Cellular Biophysics Group (BIOMS), German Cancer Research Center, Heidelberg, Germany.
authors.forename: Gernot
authors.initials: G
authors.lastname: Guigas
authors.forename: Matthias
authors.initials: M
authors.lastname: Weiss
mesh_terms: D002462:Cell Membrane / Q000737:chemistry*; D003198:Computer Simulation; D004058:Diffusion; D057927:Hydrophobic and Hydrophilic Interactions; D008051:Lipid Bilayers / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D008954:Models, Biological; D008956:Models, Chemical; D011487:Protein Conformation
chemical_list: D008051:Lipid Bilayers; D008565:Membrane Proteins