Water-soluble cyclodiphosphazanes: synthesis, gold(I) metal complexes and their in vitro antitumor studies.
The newly synthesized water-soluble cyclodiphosphazane ligands and their gold(I) complexes inhibit HeLa cell proliferation by activating p53 protein and inducing apoptosis.
Suresh
D
D
Phosphorus Laboratory, Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, 400 076, India.
Balakrishna
Maravanji S
MS
Rathinasamy
Krishnan
K
Panda
Dulal
D
Mobin
Shaikh M
SM
D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012995:Solubility; D016159:Tumor Suppressor Protein p53 / Q000187:drug effects / Q000378:metabolism; D014867:Water / Q000737:chemistry*
D006573:Heterocyclic Compounds, 1-Ring; D008024:Ligands; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D016159:Tumor Suppressor Protein p53; D014867:Water; D006046:Gold