title: Pleiotrophin induces expression of inflammatory cytokines in peripheral blood mononuclear cells.
abstract: Pleiotrophin (PTN) is a polypeptide that belongs to a family of heparin-binding growth factor, which displays mitogenic activity for a wide variety of cells. Since PTN induces the proliferation of immune cells the mechanism of action was investigated. In the present study, we show for the first time that PTN induces the expression of inflammatory cytokines including TNF-alpha, IL-1beta and IL-6 in quiescent human peripheral blood mononuclear cells (PBMC). These results emphasize the importance of PTN in the regulation of inflammatory processes. Elucidation of the mechanisms by which a host factor such PTN regulates cytokines production will significantly advance our understanding of endothelium-immunity interactions.
authors.affiliation: Laboratoire des Interférons, UFR Biomédicale des Saint Pères, Université Paris Descartes, Paris, France. ammar.achour@univ-paris5.fr
authors.forename: Ammar
authors.initials: A
authors.lastname: Achour
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: M'bika
authors.forename: Françoise
authors.initials: F
authors.lastname: Baudouin
authors.forename: Danièle
authors.initials: D
authors.lastname: Caruelle
authors.forename: José
authors.initials: J
authors.lastname: Courty
mesh_terms: D002352:Carrier Proteins / Q000494:pharmacology / Q000502:physiology*; D016207:Cytokines / Q000096:biosynthesis* / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D002352:Carrier Proteins; D016207:Cytokines; D011994:Recombinant Proteins; C066845:pleiotrophin