Interaction of Fragrance Materials With 2-Hydroxypropyl-beta-Cyclodextrin by Static and Dynamic Head-space Methods.
The stability constants for the inclusion of fragrance materials with 2-hydroxypropyl-beta-cyclodextrin (2HP-beta-C yD) in aqueous solution have been determined by the static head-space method. The 1:1 stability constants obtained by this method were in reasonable agreement with the corresponding values in the literature. In addition, the release profiles of fragrance materials from 2HP-beta-CyD aqueous solution were investigated using the dynamic head-space method. It was found that the suppression of the fragrance materials release was dependent on their stability constants.
Saito
Y
Y
Faculty of Pharmaceutical Science, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142, Japan.
Tanemura
I
I
Sato
T
T
Ueda
H
H