Effect of high fiber density ratio polysulfone dialyzer on protein removal.
OBJECTIVE
A dialyzer (APS-EX) with a higher hollow fiber density ratio was manufactured using the highest performance polysulfone hollow fiber from Asahi-Kasei Medical.


METHODS
We compared the performance of this device in comparison with hemodialysis (HD; APS-S) and hemodiafiltration (HDF) conditions (APS-S, 10 l post-HDF) to evaluate its merit as an internal filtration-enhanced dialyzer.


RESULTS
With low molecular weight proteins, APS-EX had a reduction ratio of 74.3% for beta(2)-microglobulin (beta(2)-MG), and 31.0% for alpha(1)-MG. APS-EX had a significant higher removal amount of alpha(1)-MG compared to APS-S (HDF). Significant differences were seen in albumin loss, 4.0 g for APS-EX, 3.0 g for APS-S (HDF), and 0.9 g for APS-S (HD). Using HD mode, APS-EX demonstrated a performance which was more than equivalent to approximately 10 l post-HDF.


CONCLUSIONS
The results suggested the possibility that HD equivalent to HDF can be performed safely with the ultrapure dialysate when using APS-EX with internal filtration.
Tomo
Tadashi
T
Department of Internal Medicine II, Oita University Faculty of Medicine, Oita, Japan. tomo@med.oita-u.ac.jp
Matsuyama
Makoto
M
Nakata
Takeshi
T
Kadota
Jun-Ichi
J
Toma
Shigeki
S
Koga
Nobuhiko
N
Fukui
Hiroyoshi
H
Arizono
Kenji
K
Takamiya
Tomi
T
Matsuyama
Kazuhiro
K
Ueyama
Satonori
S
Shiohira
Yoshiki
Y
Uezu
Yoshinao
Y
Higa
Akira
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000302:isolation & purification; D001798:Blood Proteins / Q000302:isolation & purification*; D004867:Equipment Design; D005260:Female; D017583:Hemodiafiltration / Q000295:instrumentation* / Q000592:standards*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D011108:Polymers / Q000494:pharmacology*; D006435:Renal Dialysis; D013450:Sulfones / Q000494:pharmacology*; D000511:alpha-Macroglobulins / Q000302:isolation & purification; D001613:beta 2-Microglobulin / Q000302:isolation & purification
D000418:Albumins; D001798:Blood Proteins; D011108:Polymers; D013450:Sulfones; D000511:alpha-Macroglobulins; D001613:beta 2-Microglobulin; C017662:polysulfone P 1700