Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis".
Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.
Selman
Colin
C
Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, 5 University Street, London WC1E 6JJ, UK.
Lingard
Steven
S
Gems
David
D
Partridge
Linda
L
Withers
Dominic J
DJ
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003433:Crosses, Genetic; D004032:Diet; D005260:Female; D006706:Homeostasis; D055504:Insulin Receptor Substrate Proteins; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D053208:Kaplan-Meier Estimate; D008136:Longevity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D012107:Research Design; D015398:Signal Transduction
D055504:Insulin Receptor Substrate Proteins; D047908:Intracellular Signaling Peptides and Proteins; C526298:Irs2 protein, mouse; D010750:Phosphoproteins