Modelling of the mitochondrial apoptosis network.
In this paper, we performed an experimental observation-based computer simulation of the regulatory network of mitochondrial apoptosis. By modelling we obtained dynamical understandings of various apoptosis-related proteins, including cytochrome c (cyt c) release and caspase activation. Through parameter analysis, we examined the role of Bcl-2 family proteins and the natural inhibitors of apoptosis in the regulatory network of apoptosis. Furthermore, the effects of several amplified loops in the network were found to enhance caspase activation and make the decision of apoptosis switch like. Consistent with most available experimental evidences, our results yield insights into the complex regulatory mechanism of mitochondrial apoptosis.
Cui
J
J
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People's Republic of China. junc@bcm.tmc.edu
Chen
C
C
Lu
H
H
Shen
P
P
D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D004789:Enzyme Activation; D008928:Mitochondria / Q000502:physiology*; D008954:Models, Biological; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology
D019253:Proto-Oncogene Proteins c-bcl-2; D020169:Caspases