title: Giving space to cell signaling.
abstract: Spatial separation of component enzymes in a pathway creates microdomains and gradients of signaling activities. Imaging techniques and computational modeling help us to understand the complex relationships between signaling and spatial information. In this issue, Neves et al. (2008) report how the propagation of spatial information is controlled by the shape of hippocampal neurons and feedback and feed-forward motifs of the beta-adrenergic receptor signaling pathway.
authors.affiliation: Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. boris.kholodenko@jefferson.edu
authors.forename: Boris N
authors.initials: BN
authors.lastname: Kholodenko
authors.forename: Walter
authors.initials: W
authors.lastname: Kolch
mesh_terms: D000818:Animals; D048430:Cell Shape; D025461:Feedback, Physiological; D006624:Hippocampus / Q000166:cytology; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D018343:Receptors, Adrenergic, beta-2 / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D018343:Receptors, Adrenergic, beta-2