title: Effect of high fiber density ratio polysulfone dialyzer on protein removal.
abstract: OBJECTIVE
  A dialyzer (APS-EX) with a higher hollow fiber density ratio was manufactured using the highest performance polysulfone hollow fiber from Asahi-Kasei Medical.
  
  
  METHODS
  We compared the performance of this device in comparison with hemodialysis (HD; APS-S) and hemodiafiltration (HDF) conditions (APS-S, 10 l post-HDF) to evaluate its merit as an internal filtration-enhanced dialyzer.
  
  
  RESULTS
  With low molecular weight proteins, APS-EX had a reduction ratio of 74.3% for beta(2)-microglobulin (beta(2)-MG), and 31.0% for alpha(1)-MG. APS-EX had a significant higher removal amount of alpha(1)-MG compared to APS-S (HDF). Significant differences were seen in albumin loss, 4.0 g for APS-EX, 3.0 g for APS-S (HDF), and 0.9 g for APS-S (HD). Using HD mode, APS-EX demonstrated a performance which was more than equivalent to approximately 10 l post-HDF.
  
  
  CONCLUSIONS
  The results suggested the possibility that HD equivalent to HDF can be performed safely with the ultrapure dialysate when using APS-EX with internal filtration.
authors.affiliation: Department of Internal Medicine II, Oita University Faculty of Medicine, Oita, Japan. tomo@med.oita-u.ac.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Tomo
authors.forename: Makoto
authors.initials: M
authors.lastname: Matsuyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakata
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kadota
authors.forename: Shigeki
authors.initials: S
authors.lastname: Toma
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Koga
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Fukui
authors.forename: Kenji
authors.initials: K
authors.lastname: Arizono
authors.forename: Tomi
authors.initials: T
authors.lastname: Takamiya
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Matsuyama
authors.forename: Satonori
authors.initials: S
authors.lastname: Ueyama
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Shiohira
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Uezu
authors.forename: Akira
authors.initials: A
authors.lastname: Higa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000302:isolation & purification; D001798:Blood Proteins / Q000302:isolation & purification*; D004867:Equipment Design; D005260:Female; D017583:Hemodiafiltration / Q000295:instrumentation* / Q000592:standards*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D011108:Polymers / Q000494:pharmacology*; D006435:Renal Dialysis; D013450:Sulfones / Q000494:pharmacology*; D000511:alpha-Macroglobulins / Q000302:isolation & purification; D001613:beta 2-Microglobulin / Q000302:isolation & purification
chemical_list: D000418:Albumins; D001798:Blood Proteins; D011108:Polymers; D013450:Sulfones; D000511:alpha-Macroglobulins; D001613:beta 2-Microglobulin; C017662:polysulfone P 1700