Influence of -55CT polymorphism of UCP3 gene on surgical results of biliopancreatic diversion.
BACKGROUND
Bariatric surgery is the most effective long-term treatment for morbid obesity, reducing obesity-associated comorbidities. The purpose of the present study was to evaluate the UCP3 promotor (-55C-->T) polymorphism outcomes 1 year after biliopancreatic diversion in morbidly obese patients.


METHODS
A sample of 40 morbidly obese patients (BMI >40 kg/m(2)) were operated. Weight, fat mass, blood pressure, basal glucose, triacylglycerols, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were measured at basal visit and at each visit. The frequency of patients with diabetes mellitus, hypertension, and hyperlipidemia was recorded at each visit.


RESULTS
Twenty-eight patients (70%) had the genotype C/C (wild group) and 12 (30%) patients C/T (mutant group). In wild type group, body mass index, weight, fat mass, systolic blood pressure, glucose, total cholesterol, low-density lipoprotein cholesterol, and triacylglycerols concentrations decreased. In mutant type group, the same parameters improved, without statistical differences with wild group. Initial weight percent loss at 1 year of follow-up was similar in both genotypes (34.1% vs 28.6%; ns).


CONCLUSIONS
Polymorphism -55C/T of the UCP3 promotor did not have an effect on weight loss or clinical outcomes after bariatric surgery.
de Luis
D A
DA
Institute of Endocrinology and Nutrition, Medicine School, Unit of Investigation, RD 056/0013, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es
Pacheco
D
D
Aller
R
R
González Sagrado
M
M
Izaola
O
O
Terroba
M C
MC
Cuellar
L
L
Conde
R
R
Martin
T
T
Perez Castrillon
J L
JL
D000328:Adult; D050110:Bariatric Surgery; D015904:Biliopancreatic Diversion / Q000379:methods*; D001795:Blood Pressure Determination; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D009767:Obesity, Morbid / Q000235:genetics* / Q000601:surgery*; D011110:Polymorphism, Genetic; D016896:Treatment Outcome; D000071247:Uncoupling Protein 3; D015431:Weight Loss / Q000235:genetics*
D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604392:UCP3 protein, human; D000071247:Uncoupling Protein 3; D002784:Cholesterol