Genome-wide studies in thyroid neoplasia.
There is much interest in the application of genome biology to the field of thyroid neoplasia, despite the relatively low mortality rate associated with thyroid cancer in general. The principal reason for this interest is that the field of thyroid neoplasia stands to benefit from the application of genomic information to address a variety of pathologic and clinical issues. In addition to practical patient care issues, there is an excellent opportunity of expand the basic understanding of thyroid carcinogenesis. In this article, the most relevant genomic work on thyroid tumors performed to date is reviewed along with some general comments about the potential impact of genomic biology on thyroid pathology and the management of patients with thyroid nodules and cancer.
Giordano
Thomas J
TJ
Department of Pathology, 1150 West Medical Center Drive, MSRB-2, C570D, University of Michigan Health System, Ann Arbor, MI 48109, USA. Giordano@umich.edu
D014408:Biomarkers, Tumor / Q000235:genetics; D002277:Carcinoma / Q000145:classification / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D002877:Chromosomes, Human; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D015894:Genome, Human; D023281:Genomics / Q000379:methods; D006801:Humans; D015201:Meta-Analysis as Topic; D035683:MicroRNAs / Q000032:analysis / Q000235:genetics; D013964:Thyroid Neoplasms / Q000145:classification / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D016606:Thyroid Nodule / Q000175:diagnosis / Q000235:genetics*
D014408:Biomarkers, Tumor; D035683:MicroRNAs