title: Value of anti-mutated citrullinated vimentin antibodies in diagnosing rheumatoid arthritis.
abstract: We assessed the diagnostic value of anti-mutated citrullinated vimentin antibodies (anti-MCV) and compared it with those of anti-cyclic citrullinated peptide antibodies (anti-CCP), IgA (ARF), IgM (MRF) and IgG (GRF) rheumatoid factors for rheumatoid arthritis (RA). Serum samples of 170 RA patients, with early and established RA, and 309 controls were tested for anti-MCV, anti-CCP, ARF, MRF and GRF using commercially available ELISA kits. Cut off of different tests was determined with ROC curves. The sensitivity and the specificity of anti-MCV were 74.1 and 79%, respectively. Sixty-five of 309 (21%) controls were anti-MCV positive. Sensitivity and specificity of anti-CCP were 72.4 and 96.1%, respectively. Only 12 of 309 (3.9%) controls were anti-CCP positive. Sensitivity of ARF, MRF and GRF were 64.1, 65.9 and 68.2%, respectively. Their specificity was 79.6, 74.4 and 68.9%, respectively. No significant association was observed between the antibodies tested and extrarticular manifestations. Anti-MCV shows comparable sensitivity but lower specificity than that of anti-CCP. They do not appear to be very useful in the diagnosis of RA.
authors.affiliation: Laboratory of Immunology, Farhat Hached Hospital, Sousse, Tunisia. sghiririm@yahoo.com
authors.forename: Rim
authors.initials: R
authors.lastname: Sghiri
authors.forename: Elyes
authors.initials: E
authors.lastname: Bouajina
authors.forename: Dhaker
authors.initials: D
authors.lastname: Bargaoui
authors.forename: Latifa
authors.initials: L
authors.lastname: Harzallah
authors.forename: Hosni Ben
authors.initials: HB
authors.lastname: Fredj
authors.forename: Samar
authors.initials: S
authors.lastname: Sammoud
authors.forename: Ibtissem
authors.initials: I
authors.lastname: Ghedira
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D011237:Predictive Value of Tests; D012372:ROC Curve; D014746:Vimentin / Q000276:immunology*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; D014746:Vimentin; C487763:cyclic citrullinated peptide