title: Evolution of Brunner gland hamartoma associated with Helicobacter pylori infection.
abstract: The pathogenesis of Brunner gland hamartoma of the duodenum is unknown. This case report describes the chronology of the development of Brunner gland hamartoma from Brunner gland hyperplasia over a 12-year interval. The study subject, a 64-year-old man with chronic iron deficiency anemia, underwent serial upper endoscopies during this period. Repeated endoscopies demonstrated the evolution of Brunner gland hyperplasia, as manifest endoscopically by a submucosal mass, to a pedunculated polyp with histologic features of Brunner gland hamartoma. The duodenal polypoid mass was removed by snare polypectomy. The patient also had a chronic Helicobacter pylori infection of the stomach. This report details the time-dependent evolution of Brunner gland hyperplasia to hamartoma in association with chronic gastric H. pylori infection.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Ravi R
authors.initials: RR
authors.lastname: Kurella
authors.forename: Hanumantha R
authors.initials: HR
authors.lastname: Ancha
authors.forename: Sanam
authors.initials: S
authors.lastname: Hussain
authors.forename: Stan A
authors.initials: SA
authors.lastname: Lightfoot
authors.forename: Richard
authors.initials: R
authors.lastname: Harty
mesh_terms: D001706:Biopsy; D002011:Brunner Glands / Q000473:pathology*; D018450:Disease Progression; D004378:Duodenal Diseases / Q000473:pathology*; D004382:Duodenitis / Q000473:pathology*; D016145:Endoscopy, Digestive System; D005500:Follow-Up Studies; D006222:Hamartoma / Q000473:pathology*; D016481:Helicobacter Infections / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D007417:Intestinal Polyps / Q000473:pathology; D008297:Male; D008875:Middle Aged