The effects of beta2 adrenergic receptor gene polymorphism in lipid profiles.
BACKGROUND
Explore the interaction between apolipoprotein E (Apo E), phospholipase A2 (PLA2) and beta2 adrenergic receptor (beta2-AR) gene polymorphisms and lipid profiles in an elderly Chinese population.


METHODS
Five hundred subjects aged 65 to 74 years were randomly selected from a community in southern Taiwan to assess the relationship between Apo E, PLA2 and beta2-AR gene polymorphisms and lipid profiles. Two hundred sixty-seven participants agreed to have venous blood drawn for DNA studies.


RESULTS
Two statistically significant differences were noted in TC and LDL-C in the Gln27Glu of the beta2-AR gene polymorphism (P = 0.007, P = 0.022). The low-income group had a higher HDL-C level (p = 0.076). The Gln27Glu polymorphism Glu/Glu or Gln/Glu subjects had lower TC levels compared to the Gln27Glu polymorphism Gln/Gln subjects (p = 0.092). Lower TC levels (p = 0.082) and lower LDL-C levels (p = 0.045) in subjects with the Cys19Arg16Glu27 haplotype. Lower TC levels (p = 0.06) were also noted in subjects with the Cys19Gly 16Glu27 haplotype. On the other hand, higher VLDL-C levels (p = 0.185) and higher triglyceride (TG) levels (p = 0.190) were noted in subjects with the Cys19Gly 16Gln27 haplotype. The epsilon2 allele combined with low income had a positive effect on HDL-C (p = 0.0011), after adding the income factor in this study.


CONCLUSIONS
When the effects of Apo E and PLA2 on lipid profiles were included in this study, beta2-AR gene polymorphisms reduced significant effect on lipid profiles. Similarly, low income increased effect on HDL-C. This study appeared that the results of gene-gene and gene-environment interaction, it should be considered in further studies for lipid profiles.
Kao
Wei-Tsung
WT
Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan. 030854@gmail.com
Yen
Yung-Chieh
YC
Lung
For-Wey
FW
D000368:Aged; D001057:Apolipoproteins E; D002681:China; D006801:Humans; D007182:Income; D008055:Lipids / Q000097:blood*; D017720:Molecular Epidemiology; D054467:Phospholipases A2; D011110:Polymorphism, Genetic / Q000502:physiology*; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*
D001057:Apolipoproteins E; D008055:Lipids; D018343:Receptors, Adrenergic, beta-2; D054467:Phospholipases A2