title: Pharmacokinetics and pharmacodynamics in the critically ill child.
abstract: An understanding of pharmacokinetics and pharmacodynamics can allow for a rational approach to prescribing medications for critically ill children. Absorption, distribution, metabolism, elimination, and the response to medications are affected by age and disease state. Various medications are used in the care of critically ill children. Many medications are prescribed for children based on dosing guidance from adult studies, however. Care providers must be cautious of the high risk for drug interactions and adverse reactions in the intensive care setting.
authors.affiliation: The Children's Hospital of Philadelphia, Abramson Research Center, 3516 Civic Center Boulevard, Suite 916 H, Philadelphia, PA 19104, USA. zuppa@email.chop.edu
authors.forename: Athena F
authors.initials: AF
authors.lastname: Zuppa
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Barrett
mesh_terms: D002648:Child; D016638:Critical Illness / Q000628:therapy*; D004358:Drug Therapy / Q000379:methods*; D006801:Humans; D010599:Pharmacokinetics; D011379:Prognosis