Severity of cardiovascular disease and health-related quality of life in men with prostate cancer: a longitudinal analysis from CaPSURE.
OBJECTIVE
To evaluate the influence of comorbid cardiovascular disease severity on health-related quality of life (HRQL) in men treated with radical prostatectomy (RP) or radiotherapy (RT) for early stage prostate cancer.


METHODS
Subjects (n=830) with non-metastatic disease who had been diagnosed in 2000-2002 were drawn from Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE). We evaluated the influence of cardiovascular disease (CVD) severity on generic and disease-specific HRQL before and 6, 12, 18, and 24 months after treatment with RP or RT. HRQL was measured with the SF-36 and the UCLA Prostate Cancer Index.


RESULTS
Men with moderate (n=193) or severe (n=51) cardiovascular disease had worse pre-treatment HRQL than did men without CVD (n=293) (P<0.01); HRQL scores were worse in men referred for RT. During 24 months of follow-up, men with moderate or severe CVD had worse SF-36 physical and mental component summaries and worse bowel function at all time points (P<0.05). Men with severe CVD also experienced a slower recovery in physical function (P=0.03) and sexual functioning (P=0.02) than did men without CVD.


CONCLUSIONS
Prostate cancer patients with moderate to severe CVD have worse HRQL during follow-up. Those with severe CVD recover their physical and sexual functioning more slowly after treatment.
van de Poll-Franse
Lonneke V
LV
Comprehensive Cancer Centre South (IKZ), Eindhoven Cancer Registry, P.O. Box 231, 5600 AE Eindhoven, The Netherlands. l.vd.poll@ikz.nl
Sadetsky
Natalia
N
Kwan
Lorna
L
Litwin
Mark S
MS
D000368:Aged; D002318:Cardiovascular Diseases / Q000503:physiopathology* / Q000523:psychology / Q000532:radiotherapy / Q000601:surgery; D006305:Health Status Indicators; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000523:psychology*; D011581:Psychological Tests; D011594:Psychometrics; D011788:Quality of Life; D011795:Surveys and Questionnaires