title: [The relation between post-acute coronary syndrome anxiety and serum levels of inflammatory factors].
abstract: OBJECTIVE
  To explore the role of inflammatory factors (interleukin-6, tumor necrosis factor alpha, high sensitive C reactive protein) in the pathogenesis of anxiety after acute coronary syndrome (ACS) by investigating the serum levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha) and high sensitive C reactive protein (hsCRP).
  
  
  METHODS
  Serum IL-6, TNFalpha and hsCRP levels were measured in 105 ACS patients within 7 days after onset of the event. Symptoms of anxiety were evaluated by self-reporting standardized questionnaire, using a validated Chinese version of Hospital Anxiety and Depression Scale (HADS-A)-Anxiety Subscale (7 items) within 72 hours of the event. Demographic and clinical data including cardiac risk factors were recorded.
  
  
  RESULTS
  The median of TNFalpha was lower in the anxious patients with ACS than that of non-anxious ones (44.55 vs 61.70, P = 0.004). Neither the levels of hsCRP nor the levels of IL-6 were found to be different between the groups with anxiety and without.
  
  
  CONCLUSIONS
  Anxiety after ACS does not increase the inflammatory reaction in the ACS patients.
authors.affiliation: Cardiology Department, Peking University People's Hospital, Beijing, China.
authors.forename: Jun-Meng
authors.initials: JM
authors.lastname: Zhang
authors.forename: Wen-Lin
authors.initials: WL
authors.lastname: Ma
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.forename: Mei-Jing
authors.initials: MJ
authors.lastname: Li
authors.forename: Ming-Zhong
authors.initials: MZ
authors.lastname: Zhao
authors.forename: Yan
authors.initials: Y
authors.lastname: Xing
authors.forename: Meng-Yun
authors.initials: MY
authors.lastname: Zhu
authors.forename: Da-Yi
authors.initials: DY
authors.lastname: Hu
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000150:complications; D000368:Aged; D001007:Anxiety / Q000097:blood* / Q000209:etiology; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D018836:Inflammation Mediators; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein