title: The role of hepatic arterial flow on portal venous and hepatic venous wedged pressure in the isolated perfused CCl4-cirrhotic liver.
abstract: In cirrhosis, hepatic venous pressure gradient is used to measure portal venous and sinusoidal pressures, as well as drug-induced decreases of elevated pressures. The aim of this study was to investigate the influence of hepatic arterial flow (HAF) changes on portal venous perfusion (PVPP) and wedged hepatic venous pressure (WHVP). Normal and CCl4-cirrhotic rats were subjected to a bivascular liver perfusion with continuous measurements of PVPP, WHVP, and hepatic arterial perfusion pressure. Flow-pressure curves were performed with the use of different flows either through the portal vein (PVF: 20-32 ml/min) or HAF (5-15 ml/min). Increases in HAF lead to significant absolute and relative increases in PVPP (P = 0.002) and WHVP (P < 0.001). Absolute changes in HAF correlated to absolute changes in PVPP (cirrhosis: r = 0.64, P < 0.001; control: r = 0.67, P < 0.001) and WHVP (cirrhosis: r = 0.71, P < 0.001; control: r = 0.82, P < 0.001). Changes in PVPP correlated to changes in WHVP due to changes in PVF only in cirrhosis (r = 0.75, P < 0.001), whereas changes in HAF correlated in both cirrhosis (r = 0.92, P < 0.001) and control (r = 0.77, P < 0.001). In conclusion, increases and decreases in HAF lead to respective changes in PVPP and WHVP. This suggests a direct influence of HAF on PVPP and WHVP most likely due to changes in sinusoidal perfusion.
authors.affiliation: Digestive Disease Section, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Zipprich
authors.forename: Mauricio R
authors.initials: MR
authors.lastname: Loureiro-Silva
authors.forename: Irita
authors.initials: I
authors.lastname: D'Silva
authors.forename: Roberto J
authors.initials: RJ
authors.lastname: Groszmann
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D002251:Carbon Tetrachloride / Q000633:toxicity; D006499:Hepatic Artery / Q000502:physiology*; D006503:Hepatic Veins / Q000502:physiology*; D008099:Liver / Q000098:blood supply*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D009924:Organ Culture Techniques; D017082:Portal Pressure / Q000502:physiology; D011169:Portal Vein / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014655:Vascular Resistance / Q000502:physiology; D014690:Venous Pressure / Q000502:physiology
chemical_list: D002251:Carbon Tetrachloride