Iloprost pretreatment before unilateral nephrectomy: an experimental study in rats.
OBJECTIVE
To evaluate the effects of iloprost administration before unilateral nephrectomy on postoperative interleukin-6 (IL-6), nitric oxide (NO), and oxidant/antioxidant status.


METHODS
Malondialdehyde, glutathione, catalase and Cu-Zn superoxide dismutase were measured in the blood and remnant kidney of Adult male Wistar albino rats to assess oxidant and antioxidant status. The rats were divided into three experimental groups: sham group (S) (n = 12); unilateral nephrectomized group (N) (n = 12); an hour before unilateral nephrectomy iloprost (1 ng/mL/kg, intraperitoneal) administered group (IN) (n = 12).


RESULTS
Iloprost administration before unilateral nephrectomy lowered oxidant parameters and IL-6 levels significantly. NO levels were increased in both N and IN groups.


CONCLUSIONS
Iloprost pretreatment before unilateral nephrectomy can reduce oxidative stress and IL-6, which increases due to anaesthesia and surgery and causes organ damage during surgery and in the short-term postoperative period.
Aytac
Erman
E
Department of General Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Seymen
Pinar
P
Dikmen
Goksel
G
Uzun
Hafize
H
Seymen
Hakki Oktay
HO
D000818:Animals; D016285:Iloprost / Q000008:administration & dosage*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D009392:Nephrectomy; D009569:Nitric Oxide / Q000097:blood*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D015850:Interleukin-6; D009569:Nitric Oxide; D016285:Iloprost