title: Synthesis, Characterization and Antitumour Activity of Some Butyltin(IV) Cysteaminates and N,N-Dimethylcysteaminates.
abstract: The synthesis and characterization of four di- and tri-n-butyltin cysteaminates and N,N-dimethylcysteaminates and three protonated / quaternized derivatives are reported. They all exhibit moderate or high in vitro cytotoxic activity. Six of seven compounds presented in this work are more active than cisplatin, etoposide and 5-fluorouracil, but less active than methotrexate and doxorubicin.
authors.affiliation: Departement of General and Organic Chemistry AOSC Faculty of Applied Sciences Free University of Brussels VUV Pleinlaan 2 Brussels B-1050 Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Gielen
authors.forename: K
authors.initials: K
authors.lastname: Handlir
authors.forename: M
authors.initials: M
authors.lastname: Hollein
authors.forename: D
authors.initials: D
authors.lastname: de Vos