Cystatin C as a marker of cognitive function in elders: findings from the health ABC study.
We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain beta-amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini-Mental State Examination or Digit Symbol Substitution Test (p <or= 0.02) compared with those with intermediate/low level and 7 years greater decline (p <or= 0.04). Incident cognitive impairment (decline >or=1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini-Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15).
Yaffe
Kristine
K
Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94121, USA. kristine.yaffe@ucsf.edu
Lindquist
Karla
K
Shlipak
Michael G
MG
Simonsick
Eleanor
E
Fried
Linda
L
Rosano
Caterina
C
Satterfield
Suzanne
S
Atkinson
Hal
H
Windham
B Gwen
BG
Kurella-Tamura
Manjula
M
D017677:Age Distribution; D000368:Aged; D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D015992:Body Mass Index; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D003072:Cognition Disorders / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D015897:Comorbidity; D055316:Cystatin C; D015891:Cystatins / Q000032:analysis / Q000097:blood*; D018450:Disease Progression; D004522:Educational Status; D005260:Female; D006306:Health Surveys; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008569:Memory Disorders / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D011446:Prospective Studies; D044469:Racial Groups; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology
D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins