title: Synthesis of silicon and germanium containing heteroaromatic sulfides as cholesterol level lowering and vasodilating agents.
abstract: Silicon and germanium containing heteroaromatic sulfides have been prepared using phase transfer catalytic (PTC) system thiol / Si or Ge containing alkyl halide / solid KOH / 18- crown-6 / toluene. The target sulfides were isolated in yields up to 92 %. It has been found that 2-{[dimethyl (beta-triethylgermylethyl)-silylmethyl]thio}-1-methylimidazole and 2-{[dimethyl(beta-triphenylsilylethyl) silyl-methyl]thio}benzothiazole are the most active cholesterol level lowering and vasodilating agents.
authors.affiliation: Latvian Institute of Organic Synthesis 21 Aizkraukles street Riga LV-1006 Latvia.
authors.forename: K
authors.initials: K
authors.lastname: Rubina
authors.forename: E
authors.initials: E
authors.lastname: Abele
authors.forename: P
authors.initials: P
authors.lastname: Arsenyan
authors.forename: R
authors.initials: R
authors.lastname: Abele
authors.forename: M
authors.initials: M
authors.lastname: Veveris
authors.forename: E
authors.initials: E
authors.lastname: Lukevics