K(ATP) channel polymorphism is associated with left ventricular size in hypertensive individuals: a large-scale community-based study.
ATP-sensitive K+ (K(ATP)) channel mutations have been identified in individuals with dilated cardiomyopathy and overt heart failure. Here, a common E23K functional polymorphism in the Kir6.2 channel pore versus cardiac phenotype was studied in a cross-sectional community-based cohort (n = 2,031). The KK genotype was associated with greater left ventricular size among subjects with increased stress load due to hypertension. These findings implicate Kir6.2 K23 as a risk factor for adverse subclinical myocardial remodeling, and underscore the significance of cardiac K(ATP) channels within the population.
Reyes
Santiago
S
Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Terzic
Andre
A
Mahoney
Douglas W
DW
Redfield
Margaret M
MM
Rodeheffer
Richard J
RJ
Olson
Timothy M
TM
D000368:Aged; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000473:pathology*; D008239:Lysine / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009929:Organ Size / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics*; D020257:Ventricular Remodeling / Q000235:genetics; D000099161:Kcnj11 Channel
D008239:Lysine; D024661:Potassium Channels, Inwardly Rectifying; D000099161:Kcnj11 Channel