[Carbohydrate metabolism in the liver of rats in food deprivation and experimental diabetes].
In experiments with starving rats (Rattus rattus L.) and rats with alloxan-induced diabetes, the activity of enzymes and the contents of metabolites of the main metabolic pathways have been studied. It has been shown that adaptation of carbohydrate metabolism to these stress conditions has common trends: intensification of gluconeogenetic processes and glyoxylate cycle induction are observed against the background of decrease in the activities of glycolytic enzymes and the pentose phosphate pathway. A hypothetical mechanism of adaptation of rat liver cell metabolism to a deficiency of glucose as the main energy substrate is proposed.
Eprintsev
A T
AT
Shevchenko
M Iu
MIu
Popov
V N
VN
D000222:Adaptation, Physiological; D000818:Animals; D050260:Carbohydrate Metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D005508:Food Deprivation; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats