[Sperm DNA damage and assisted reproductive technology].
With the introduction of assisted reproductive technology (ART), sperm assessment has developed progressively, from conventional semen routine tests to novel cellular and molecular measures. Sperm DNA damage is a new marker of male fertility, whose genetic mechanism involves abnormal package and segregation of chromatin, oxidative stress, abnormal cell apoptosis, etc. Sperm chromatin structure assay (SCSA) is one of the common techniques to measure sperm DNA damage. Sperm DNA damage might be associated with the pregnancy outcome of ART, recurrent spontaneous abortion and potential genetic risk of ICSI offspring. Some treatment strategies might reduce the percentage of sperm DNA damage and increase the success rate of ART, including oral administration of antioxygen drugs, ICSI with testis sperm, sperm freezing and preservation, removing of etiological factors, traditional Chinese medicine, and so on. This review focuses on the mechanism and detection of sperm DNA damage, its association with reproductive outcomes, and relevant treatment strategies in assisted reproductive technology.
Xu
Zhi-Peng
ZP
Center of Reproductive Medicine, Drum Tower Hospital Affiliated to Nanjing University School of Medicine, Nanjing, Jiangsu 210008, China. xzpbio@hotmail.com
Sun
Hai-Xiang
HX
Zhang
Ning-Yuan
NY
D004249:DNA Damage; D006801:Humans; D007248:Infertility, Male / Q000628:therapy; D008297:Male; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects / Q000379:methods*; D013094:Spermatozoa / Q000378:metabolism*