title: A comparison of the Antileukaemic Effects of Recombinant Human Tumour Necrosis Factor-alpha and its Muteins on Leukaemia L1210 and Leukaemia P388 in Mice.
abstract: We investigated the influence of recombinant human tumour necrosis factor alpha (TNF-alpha) and its derivatives termed muteins III, V, VI-in which the first 3 to 7 amino acids of native TNF-alpha have been replaced-on the survival time of mice inoculated with leukaemia L1210 or leukaemia P338. TNF-alpha prolonged the survival of mice with leukaemia L1210 but did not have any therapeutic activity in leukaemia P388-bearing mice. Muteins-treated mice with leukaemia P388 lived longer than animals receiving TNF-alpha, while those inoculated with leukaemia L1210 did not show any significant prolongation of life compared with the TNF-alpha treated group. The results presented in this report indicate that the antileukaemic activity of TNF-alpha is governed at least in part by the nature of the N-terminal amino acids.
authors.affiliation: 2nd Clinic of Internal Medicine Medical University of Łódź Pabianicka 62 Łódź 93-513 Poland.
authors.forename: K
authors.initials: K
authors.lastname: Warzocha
authors.forename: J
authors.initials: J
authors.lastname: Góra-Tybor
authors.forename: M
authors.initials: M
authors.lastname: Kwinkowski
authors.forename: B
authors.initials: B
authors.lastname: Szymańska
authors.forename: T
authors.initials: T
authors.lastname: Robak