Guadinomines, Type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. II: physico-chemical properties and structure elucidation.
The structures of guadinomines, new inhibitors of a bacterial Type III secretion system produced by Streptomyces sp. K01-0509, were elucidated by spectroscopic studies including various NMR experiments. Guadinomines A, B, C(1), C(2) and D consist of a carbamoylated cyclic guanidinyl moiety, an alkyl chain moiety and an L-Ala-L-Val moiety in common, while guadinomic acid is a smaller molecule consisting of a carbamoylated cyclic guanidinyl moiety and a hydroxyl hexanoate moiety.
Iwatsuki
Masato
M
The Kitasato Institute, Japan.
Uchida
Ryuji
R
Yoshijima
Hitomi
H
Ui
Hideaki
H
Shiomi
Kazuro
K
Kim
Yong-Pil
YP
Hirose
Tomoyasu
T
Sunazuka
Toshiaki
T
Abe
Akio
A
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002208:Caproates / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D048289:Imidazolidines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D002208:Caproates; D004151:Dipeptides; D048289:Imidazolidines; C530707:guadinomic acid; C530702:guadinomine A; C530703:guadinomine B; C530704:guadinomine C; C530705:guadinomine D; C530706:guadinomine E