title: Cypermethrin effects on the adult mice seminal glands.
abstract: The insecticide cypermethrin acts upon the sodium channels. Their effects over animal health are not understood. Here, the effects of cypermethrin on the seminal glands (SGs) are studied (1/5 DL50 i.p.). Forty-five adult mice (CF1) were distributed in three groups: (1) untreated, (2) vehicle (oil), and (3) experimental (cypermethrin in oil). The animals were sacrificed at 1 and each 8.6 days. The SGs were processed for histology: Haematoxylin/P.A.S, Thyonin (0.6%) and Immunohistochemistry (Ki-67). In the SGs was quantified: the epithelium height, mastocytes, and cell proliferation. In the results, cypermethrin exerts an intense effect on epithelium height and cell proliferation. A net increase of both parameters was observed at 24 h (p0.05). However, the mastocytes increased drastically and progressively during the experimental period (p0.05). Then, the effects have acute manifestations, which would be responsible for the potential changes in the male's reproductive potentiality.
authors.affiliation: Laboratory of Reproduction, Faculty of Medicine, Medical School, University of Chile, Avenida Independencia 1027, Santiago. Chile. hrodrigu@med.uchile.cl
authors.forename: H
authors.initials: H
authors.lastname: Rodriguez
authors.forename: C
authors.initials: C
authors.lastname: Tamayo
authors.forename: J
authors.initials: J
authors.lastname: Inostroza
authors.forename: C
authors.initials: C
authors.lastname: Soto
authors.forename: E
authors.initials: E
authors.lastname: Bustos-Obregón
authors.forename: R
authors.initials: R
authors.lastname: Paniagua
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D049109:Cell Proliferation / Q000187:drug effects; D007150:Immunohistochemistry; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D011722:Pyrethrins / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology; D012669:Seminal Vesicles / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013997:Time Factors
chemical_list: D007306:Insecticides; D011722:Pyrethrins; C017160:cypermethrin