Palladium-catalyzed beta-allylation of 2,3-disubstituted indoles.
Given the prevalence of the indole nucleus in biologically active compounds, the direct C3-functionalization of 2,3-disubstituted indoles represents an important problem. Described is a general, high-yielding method for the palladium-catalyzed beta-allylation of carba- and heterocycle fused indoles, including complex natural product substrates.
Kagawa
Natsuko
N
Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.
Malerich
Jeremiah P
JP
Rawal
Viresh H
VH
D000498:Allyl Compounds / Q000737:chemistry; D002227:Carbazoles / Q000737:chemistry; D002243:Carbolines / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D000498:Allyl Compounds; D002227:Carbazoles; D002243:Carbolines; D007211:Indoles; D010165:Palladium