title: Increased aortic root diameters in patients with acromegaly.
abstract: OBJECTIVE
  The clinical manifestations of acromegalic cardiomyopathy include arrhythmias, valvular regurgitation, concentric left ventricular (LV) hypertrophy, and LV systolic and diastolic dysfunction. At present, it is unknown whether acromegaly also affects the aortic root.
  
  
  METHODS
  Aortic root diameters were prospectively assessed in 37 acromegalic patients (18 patients with active disease and 19 with controlled disease) by conventional two-dimensional and Doppler echocardiography before, and after, an observation period of 1.9 years (range 1.5-3.0 years). Baseline parameters were compared with healthy controls.
  
  
  RESULTS
  The diameters of the aortic root at the sino-tubular junction and the ascending aorta were increased in patients with acromegaly: 30+/-4 vs 26+/-3 mm (P=0.0001) and 33+/-5 vs 30+/-4 mm (P=0.006) respectively. The diameter of the aortic root at the aortic annulus and aortic sinus were not different from controls. During follow-up, the aortic root diameters increased at the levels of the annulus and the sinotubular junction (P=0.025 and P=0.024 respectively), whereas there was no change in the diameters at the levels of the sinus and the ascending aorta during follow-up. Baseline aortic root diameters were not influenced by disease duration, current disease activity, or blood pressure. When patients with active and inactive disease were analyzed separately, only the diameter of the sinotubular junction increased in patients with inactive acromegaly during follow-up (P=0.031).
  
  
  CONCLUSIONS
  Aortic root diameters are increased in patients with acromegaly compared with healthy controls.
authors.affiliation: Departments of Endocrinology, C4-R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. a.a.van_der_klaauw@lumc.nl
authors.forename: Agatha A
authors.initials: AA
authors.lastname: van der Klaauw
authors.forename: Jeroen J
authors.initials: JJ
authors.lastname: Bax
authors.forename: Johannes W A
authors.initials: JW
authors.lastname: Smit
authors.forename: Eduard R
authors.initials: ER
authors.lastname: Holman
authors.forename: Victoria
authors.initials: V
authors.lastname: Delgado
authors.forename: Gabe B
authors.initials: GB
authors.lastname: Bleeker
authors.forename: Nienke R
authors.initials: NR
authors.lastname: Biermasz
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Roelfsema
authors.forename: Johannes A
authors.initials: JA
authors.lastname: Romijn
authors.forename: Alberto M
authors.initials: AM
authors.lastname: Pereira
mesh_terms: D000172:Acromegaly / Q000150:complications* / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000473:pathology*; D001794:Blood Pressure; D016022:Case-Control Studies; D004108:Dilatation, Pathologic; D005260:Female; D006349:Heart Valve Diseases / Q000150:complications* / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016277:Ventricular Function, Left / Q000502:physiology