Synthesis, characterization and antitumour activity of metal complexes of 5-carboxy-2-thiouracil.
Metal complexes of 5-carboxy-2-thiouracil with Mn(ll), Co(ll), Ni(ll), Cu(ll), Zn(ll) and Cd(ll) ions were synthesized, characterized, and subjected to a screening system for evaluation of antitumour activity against Sarcoma-180 (S-180) tumour cells. The complexes were characterized by elemental analysis, infrared, electronic spectra, room temperature magnetic measurements and powder X-ray diffraction. The antitumour activity results indicate that some complexes have antitumour activity both in vivo and in vitro against S-180 tumour cells.
Singh
U P
UP
Department of Chemistry University of Roorkee Roorkee 247 667 India.
Singh
S
S
Singh
S M
SM