title: Joining the army of proteasome inhibitors.
abstract: An article in this issue of Chemistry & Biology (Hines et al., 2008) and a recent study in Nature (Groll et al., 2008) establish three natural products as novel proteasome inhibitors. These inhibitors, discovered in an unusual way, reveal a different mechanism of proteasome inhibition and suggest new therapeutic application of its inhibitors.
authors.affiliation: Norris Cotton Cancer Center and Department of Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, NH 03756, USA. alexei.f.kisselev@dartmouth.edu
authors.forename: Alexei F
authors.initials: AF
authors.lastname: Kisselev
mesh_terms: D015853:Cysteine Proteinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D061988:Proteasome Inhibitors; D014961:X-Ray Diffraction
chemical_list: D015853:Cysteine Proteinase Inhibitors; D061988:Proteasome Inhibitors