Toxicity profiles in vivo in mice and antitumour activity in tumour-bearing mice of di- and triorganotin compounds.
The in vivo toxicity profiles in mice and the antitumour activity in tumour bearing mice were screened for four di-n-butyltin and five triorganotin carboxylates, di-n-butyltin diterebate (5), bis(phenylacetate) (6), bis(deoxycholate) (7), bis(lithocholate) (8), tri-n-butyltin terebate (9), cinnamate (10), and triphenyltin terebate (11).At their maximum tolerated dosis (MTD), no antitumour effect (T/C ~1) was observed for the compounds 5, 7, 9, 10 and 11. The compounds 6 (T/C = 0.51) and 8 (T/C = 0.42) showed clear antitumour activity after single dose administration and might therefore be of interest for further antitumour activity studies.
Gielen
M
M
Free University of Brussels VUB Faculty of Applied Sciences, Room 8G512 Pleinlaan 2 Brussels B-1050 Belgium.
Willem
R
R
Dalil
H
H
de Vos
D
D
Kuiper
C M
CM
Peters
G J
GJ