Apoptosis induced by metal complexes and interaction with dexamethasone.
Apoptosis induced by rhodium II amidate, rhodium II propionate, cisplatin and interactions with dexamethaxone were studied on some human leukemia cell lines Raji, Jurkat and U937. Apoptosis was studied by flow cytometry, agarose gel electrophoresis and morphological analysis. Rhodium II propionate induced apoptosis in all the three cell lines, Rhodium II amidate, in the lymphoid cell lines Jurkat and Raji, and cisplatin, only in the Jurkat, a T lymphoid cell line. It has also been observed that the addition of dexamethasone enhances the apoptosis index only in U937, a monocytic line with a glucocorticoid receptor bearing.
Kim
Jung Sun
JS
Institute of Biomedical Sciences of the University of São Paulo Department of Pharmacology Av. Prof. Lineu Prestes, 1524 São Paulo SP- 05508-900 Brazil.
Barros
José Carlos Almeida
JC
Zyngier
Szulim Ber
SB