title: Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora.
abstract: A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown gamma-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.
authors.affiliation: Mikrobiologisches Institut, Universität Tübingen, Tübingen, Germany. hans-peter.fiedler@uni-tuebingen.de
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
authors.forename: Christina
authors.initials: C
authors.lastname: Bruntner
authors.forename: Julia
authors.initials: J
authors.lastname: Riedlinger
authors.forename: Alan T
authors.initials: AT
authors.lastname: Bull
authors.forename: Gjert
authors.initials: G
authors.lastname: Knutsen
authors.forename: Michael
authors.initials: M
authors.lastname: Goodfellow
authors.forename: Amanda
authors.initials: A
authors.lastname: Jones
authors.forename: Luis
authors.initials: L
authors.lastname: Maldonado
authors.forename: Wasu
authors.initials: W
authors.lastname: Pathom-aree
authors.forename: Winfried
authors.initials: W
authors.lastname: Beil
authors.forename: Kathrin
authors.initials: K
authors.lastname: Schneider
authors.forename: Simone
authors.initials: S
authors.lastname: Keller
authors.forename: Roderich D
authors.initials: RD
authors.lastname: Sussmuth
mesh_terms: D039903:Actinobacteria / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D006801:Humans; D008826:Microbial Sensitivity Tests; D009429:Netropsin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; C529559:proximicin A; C529560:proximicin B; C529561:proximicin C; D009429:Netropsin