title: [Surgical treatment of primary hyperparathyroidism with intraoperative iPTH determination].
abstract: BACKGROUND
  Primary hyperparathyroidism (pHPT) is most frequently caused by a solitary adenoma. Surgical intervention has a high cure rate, particularly when associated with a fast intraoperative intact parathyroid hormone (IOPTH) assay.
  
  
  OBJECTIVE
  to evaluate the performance and accuracy when applying this technique.
  
  
  METHODS
  we conducted a retrospective study of the last 20 patients with pHPT (mean age 59, range 24-75) that had a surgical intervention in our unit. IOPTH was used in 14 patients, with dosage at 5, 10, 15 and 30 minutes after removal of the adenoma.
  
  
  RESULTS
  The localization exams had a sensitivity of >75%. The surgical procedure of choice was a unilateral dissection through a 4cm central mini-incision, with all patients experiencing a reduction of >50% of the IOPTH at 10 minutes. There were no surgical complications and the average length of the follow-up period was 11.4 months. The mean calcemia and iPTH dosage progression, from pre-surgery to the last follow-up visit, was respectively of 11 (SD1) to 9.4 (SD0.5) mg/dl and of 233.3 (SD177.5) to 57.1 (SD42) pg/ml. Symptoms improved in all patients.
authors.affiliation: Serviço de Cirurgia II, Hospital de Egas Moniz, Lisboa.
authors.forename: Miguel
authors.initials: M
authors.lastname: Allen
authors.forename: Isabel
authors.initials: I
authors.lastname: Almeida
authors.forename: Joaquim
authors.initials: J
authors.lastname: Torrinha
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood* / Q000601:surgery*; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D012189:Retrospective Studies
chemical_list: D010281:Parathyroid Hormone