A technetium intermediate specifically promotes deprotection of trifluoroacetyl HYNIC during radiolabelling under mild conditions.
The trifluoroacetyl group protects the nucleophilic HYNIC from unwanted side reactions yet allows radiolabelling with technetium-99m under mild conditions, due to efficient and specific promotion of deprotection by a technetium complex intermediate.
Surfraz
M Bashir-Uddin
MB
Cancer Research Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK.
Biagini
Stefano C G
SC
Blower
Philip J
PJ
D006834:Hydrazines / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D015394:Molecular Structure; D009539:Nicotinic Acids / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013667:Technetium / Q000737:chemistry*; D013997:Time Factors
C120392:6-hydrazinopyridine-3-carboxylic acid; D006834:Hydrazines; D009539:Nicotinic Acids; D009942:Organometallic Compounds; D013667:Technetium