title: Randomized clinical trial of intrapartum clindamycin cream for reduction of group B streptococcal maternal and neonatal colonization.
abstract: OBJECTIVE
  In a randomized trial, we sought to determine whether 2% clindamycin cream administered intravaginally during labor to group B streptococcal-colonized pregnant women without risk factors would decrease maternal and neonatal colonization.
  
  
  METHODS
  The eligible women were randomized to receive either cream or no treatment. Two hours after treatment or admission, the patients were tested with rectal and vaginal cultures. The neonates of the study patients were also tested.
  
  
  RESULTS
  Of women randomized to cream, 5 of 5 remained positive and 2 (33%) of their 6 neonates were positive. Of 4 randomized to no treatment, 3 (75%) remained positive and 1 (25%) of 4 neonates was positive.
  
  
  CONCLUSIONS
  Intravaginal 2% clindamycin cream was ineffective in reducing colonization with group B streptococci.
authors.affiliation: Department of Obstetrics and Gynecology Perinatal Clinical Research Center University of Colorado School of Medicine, Denver, CO 80262, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Gibbs
authors.forename: F
authors.initials: F
authors.lastname: McNabb