Survival and Histopathological Study of Animals Bearing Ehrlich Tumor Treated With a Rhodium(II) Amidate.
The survival of 90% of a tumor-bearing population treated with the complex Rh(2) (CF(3)CONH)(4) was examined and the pharmacological parameter Surv(90) determined. Histopathological alterations raised for this drug in several tissues were studied in Balb-c mice. A Surv(90) dose of 3.8x 10(-5) mol/kg was found.
Espósito
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University of São Paulo Institute of Chemistry Av. Prof. Lineu Prestes, 748 - r. 1265 São Paulo 055508-900 Brazil.
Zyngier
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SB
Najjar
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Paes
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RP
Ueda
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Barros
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JC