title: Safety, feasibility, and hemodynamic and blood flow effects of active compression-decompression of thorax and abdomen in patients with cardiac arrest.
abstract: OBJECTIVE
  During closed chest compression for cardiac arrest, any increase in coronary perfusion pressure accounts for a proportional increase in myocardial blood flow and therefore the resuscitability of the patient. The objectives of this study were to evaluate the safety, feasibility, and hemodynamic effects of phased chest and abdominal compression-decompression and to compare it with mechanical chest compression during cardiopulmonary resuscitation.
  
  
  METHODS
  In this prospective, single-center, phase II study, we compared patients treated with the Datascope Lifestick Resuscitator with patients who had been treated with mechanical precordial compression.
  
  
  METHODS
  Emergency department of a tertiary care university hospital.
  
  
  METHODS
  We included 31 patients with cardiac arrest who had received cardiopulmonary resuscitation in the emergency department.
  
  
  METHODS
  The Lifestick device was used in 20 patients. In 11 patients, mechanical chest compression with the Thumper device was used as a control intervention.
  
  
  RESULTS
  We evaluated the safety, feasibility, and hemodynamic effects of both interventions and observed, with the help of echocardiography, the mechanisms through which blood flow was generated. We found no significant difference between the use of the Lifestick device and standard chest compression with the Thumper device in resuscitations. Most operators regarded the Lifestick as a feasible alternative to the Thumper. We could observe a mean increase in coronary perfusion pressure of 9.33 mm Hg (interquartile range, 1.96-14.36; p = .08) and an increase of end-tidal CO2 of 10 mm Hg (interquartile range, 5-16; p = .003) (1333Pa [interquartile range, 665-2133]) during resuscitation with the Lifestick compared with using the Thumper.
  
  
  CONCLUSIONS
  In this preliminary study, resuscitation with the Lifestick was found to be safe and feasible. The design of the study and small number of patients included in it limit the conclusions about the hemodynamic effects of the Lifestick.
authors.affiliation: Department of Emergency Medicine, Medical University of Vienna, Vienna General Hospital, Vienna, Austria.
authors.forename: Christof
authors.initials: C
authors.lastname: Havel
authors.forename: Andrea
authors.initials: A
authors.lastname: Berzlanovich
authors.forename: Fritz
authors.initials: F
authors.lastname: Sterz
authors.forename: Hans
authors.initials: H
authors.lastname: Domanovits
authors.forename: Harald
authors.initials: H
authors.lastname: Herkner
authors.forename: Andrea
authors.initials: A
authors.lastname: Zeiner
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Behringer
authors.forename: Anton N
authors.initials: AN
authors.lastname: Laggner
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D002245:Carbon Dioxide / Q000097:blood*; D016887:Cardiopulmonary Resuscitation / Q000295:instrumentation*; D003326:Coronary Circulation / Q000502:physiology*; D017548:Echocardiography, Transesophageal; D004562:Electrocardiography; D004636:Emergency Service, Hospital; D004867:Equipment Design; D004869:Equipment Safety; D005240:Feasibility Studies; D005260:Female; D006323:Heart Arrest / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology*; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012121:Respiration, Artificial; D016896:Treatment Outcome
chemical_list: D002245:Carbon Dioxide