title: Total synthesis of sanguiin H-5.
abstract: Using an atropdiastereoselective oxidative biaryl coupling as the key step, the total synthesis of the ellagitannin natural product sanguiin H-5 is reported. Both organomagnesium and organozinc based metalation methodologies were used to efficiently construct the strained medium-ring core of the natural product.
authors.affiliation: Department of Chemistry, University of Cambridge, Cambridge, UK.
authors.forename: Xianbin
authors.initials: X
authors.lastname: Su
authors.forename: David S
authors.initials: DS
authors.lastname: Surry
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Spandl
authors.forename: David R
authors.initials: DR
authors.lastname: Spring
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D047348:Hydrolyzable Tannins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D001688:Biological Products; D047348:Hydrolyzable Tannins; C530468:sanguiin H-5