Outcomes in HIV-infected patients who develop tuberculosis after starting antiretroviral treatment in Malawi.
A retrospective review was conducted of patients starting antiretroviral treatment (ART) at Mzuzu Central Hospital, Malawi, to identify those who developed tuberculosis (TB) within 6 months of commencing ART and document their treatment outcomes. Of 2933 patients, 22 (0.75%) developed active TB, 17 (77%) of whom had commenced ART as a result of unexplained weight loss and/or fever. Of those who developed TB, 41% successfully completed anti-tuberculosis treatment, with lower survival probabilities than patients who did not develop TB. Easier methods are needed to diagnose TB in human immunodeficiency virus-infected patients and to prevent patients from developing TB while on ART.
Yu
J K-L
JK
Taiwan Medical Mission in Malawi, International Cooperation and Development Fund, Taipei, Taiwan.
Bong
C-N
CN
Chen
S C-C
SC
Dzimadzi
R
R
Lu
D-Y
DY
Makombe
S D
SD
Schouten
E J
EJ
Kamoto
K
K
Harries
A D
AD
D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D002648:Child; D015897:Comorbidity; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008295:Malawi; D012189:Retrospective Studies; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology* / Q000401:mortality
D044966:Anti-Retroviral Agents; D000995:Antitubercular Agents; D007538:Isoniazid