Controlled release scaffolds for bone tissue engineering.
Bone disease and trauma can sometimes create defects that require more than current clinical therapies can provide for effective healing. Scaffolds that release bioactive agents such as drugs offer additional benefits in this regard in comparison to those whose main requirements are space filling and load bearing. This review details a variety of recent research on scaffold carrier systems that release osteogenic drugs for orthopaedic treatment purposes. The controlled release scaffolds presented are created from a variety of materials (such as tricalcium phosphate, hydrogel systems and poly(D,L-lactide)) and release drugs such as statins, bisphosphonates and a variety of growth factors.
Cartmell
Sarah
S
Institute of Science and Technology in Medicine, University of Keele, Medical Research Unit, Hartshill, Stoke-on-Trent, Staffordshire, United Kingdom. s.h.cartmell@keele.ac.uk
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D016723:Bone Remodeling / Q000187:drug effects; D018786:Bone Substitutes; D001842:Bone and Bones / Q000187:drug effects* / Q000503:physiopathology; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage*; D010012:Osteogenesis / Q000187:drug effects; D023822:Tissue Engineering; D054457:Tissue Scaffolds
D000900:Anti-Bacterial Agents; D050071:Bone Density Conservation Agents; D018786:Bone Substitutes; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D036341:Intercellular Signaling Peptides and Proteins