title: Miconazole revisited: new evidence of antifungal efficacy from laboratory and clinical trials.
abstract: In the past 40 years imidazoles have been used extensively in medicine for their antifungal properties. All members of the azole antifungal family inhibit ergosterol biosynthesis. However, the discovery of an additional fungicidal mode of action for miconazole has drawn renewed attention to this compound. In this article we review recent evidence of mechanistic efficacy, as well as clinical trial results of miconazole in new topical formulations.
authors.affiliation: Dept of Diagnostic Sciences, University of Alabama at Birmingham, Birmingham, AL 35294-0007, USA. abarasch@uab.edu
authors.forename: Andrei
authors.initials: A
authors.lastname: Barasch
authors.forename: Andreea Voinea
authors.initials: AV
authors.lastname: Griffin
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D008825:Miconazole / Q000494:pharmacology* / Q000627:therapeutic use*; D050296:Microbial Viability; D009181:Mycoses / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D008825:Miconazole