title: Proteomics in atherosclerosis.
abstract: Atherothrombosis is the underlying cause of several clinical manifestations, such as acute coronary syndromes, cerebrovascular disease, and peripheral artery disease, which together are the leading cause of death in the Western world. Proteins from vascular cells or atherosclerotic plaques that are present in plasma are modified along the different steps of atherosclerotic development and constitute target candidates for vascular research, particularly in the search for novel biological markers of cardiovascular risk. In this review, we summarize proteomic techniques and the most recent results obtained by application of these high-throughput strategies to cardiovascular samples.
authors.affiliation: Vascular Research Laboratory, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040, Madrid, Spain.
authors.forename: Roxana
authors.initials: R
authors.lastname: Martinez-Pinna
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Martin-Ventura
authors.forename: Sebastian
authors.initials: S
authors.lastname: Mas
authors.forename: Luis Maria
authors.initials: LM
authors.lastname: Blanco-Colio
authors.forename: Jose
authors.initials: J
authors.lastname: Tuñon
authors.forename: Jesus
authors.initials: J
authors.lastname: Egido
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D015415:Biomarkers; D001792:Blood Platelets / Q000378:metabolism; D001808:Blood Vessels / Q000378:metabolism; D002853:Chromatography, Liquid; D015180:Electrophoresis, Gel, Two-Dimensional; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D051379:Mice; D011506:Proteins / Q000032:analysis; D040901:Proteomics / Q000379:methods*; D012307:Risk Factors; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D018629:Spectrometry, Mass, Secondary Ion
chemical_list: D015415:Biomarkers; D011506:Proteins