title: Preoperative administration of esomeprazole has no influence on frequency of refluxes.
abstract: OBJECTIVE
  To examine the effect of esomeprazole in a fixed time setting on gastric content volume, gastric acidity, gastric barrier pressure, and reflux propensity.
  
  
  METHODS
  Randomized, controlled, double-blind trial.
  
  
  METHODS
  21 healthy, ASA I physical status volunteers.
  
  
  METHODS
  Esomeprazole was given 12 hours and one hour before investigation. Before the study, a multichannel intraluminal impedance catheter, pH monitoring data logger (PHmetry) catheter, and an intragastric-esophageal manometry catheter were placed nasally after topical anesthesia.
  
  
  METHODS
  Gastric acidity and gastric content volume were determined by PHmetry after aspiration of gastric contents over a nasogastric tube. Gastroesophageal reflux and intragastric-esophageal barrier pressure were investigated by multichannel intraluminal impedance measurement, PHmetry, and intragastric-esophageal manometry.
  
  
  RESULTS
  The pH of gastric contents was significantly (P < 0.001) higher after esomeprazole (mean [25th-75th percentile], 4.2 [3.9-4.8] vs 2.0 [1.9-2.7]), and gastric content volume was significantly (P < 0.001) lower (5.0 mL [3.0-12.0] vs 15 mL [10.0-25.0]) in comparison to placebo. No significant difference between esomeprazole and placebo was found with respect to number of refluxes per person, duration of reflux, or barrier pressure.
  
  
  CONCLUSIONS
  Esomeprazole in a fixed time setting can markedly increase the pH of gastric contents and decrease gastric content volume, but has no influence on the frequency, duration of refluxes, or gastroesophageal barrier pressure.
authors.affiliation: Department of Traumatology and Sports Medicine, Innsbruck Medical University, A-6020 Innsbruck, Austria. hans.jeske@i-med.ac.at <hans.jeske@i-med.ac.at>
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Jeske
authors.forename: Jan
authors.initials: J
authors.lastname: Borovicka
authors.forename: Achim
authors.initials: A
authors.lastname: von Goedecke
authors.forename: Werner
authors.initials: W
authors.lastname: Tiefenthaler
authors.forename: Matthias
authors.initials: M
authors.lastname: Hohlrieder
authors.forename: Thomas
authors.initials: T
authors.lastname: Heidegger
authors.forename: Arnulf
authors.initials: A
authors.lastname: Benzer
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D017097:Electric Impedance; D064098:Esomeprazole / Q000627:therapeutic use*; D005260:Female; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000517:prevention & control*; D005766:Gastrointestinal Contents; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D011312:Pressure
chemical_list: D000897:Anti-Ulcer Agents; D064098:Esomeprazole