title: Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. Synthesis, Characterization and In Vitro Cytostatic Assays.
abstract: The synthesis, characterization and biological assays of two new rhodium carboxylate sugar derivatives and respective cyclosphosphamide adducts are described. The compounds, characterized by (13)C and (1)H NMR, infrared and UV-visible spectra, presented high water solubility and hydration grades were confirmed given the concordance between thermal and CHN analyses. The adducts were active in vitro against K-562 cells.
authors.affiliation: Faculty of Pharmaceutical Sciences University of São Paulo SP 05389-970 Brazil.
authors.forename: E de S
authors.initials: Ede S
authors.lastname: Gil
authors.forename: M I
authors.initials: MI
authors.lastname: Gonçalves
authors.forename: E I
authors.initials: EI
authors.lastname: Ferreira
authors.forename: S B
authors.initials: SB
authors.lastname: Zyngier
authors.forename: R
authors.initials: R
authors.lastname: Najjar