Primary central nervous system lymphoma can be histologically diagnosed after previous corticosteroid use: a pilot study to determine whether corticosteroids prevent the diagnosis of primary central nervous system lymphoma.
The objective is to determine whether corticosteroid administration before biopsy prevents histopathological diagnosis of primary central nervous system lymphoma (PCNSL). A retrospective review was performed of immunocompetent PCNSL patients from 1985 to 2005. A total of 109 patients was identified. Sixty-eight (63.6%) patients received corticosteroids before diagnosis. Thirteen patients (of 109; 12%) had undergone repeat brain biopsy to confirm PCNSL. These included 8 (of 68) patients who had received corticosteroids (12%), and 5 (of 39) who had not (13%) (p = 1.0). The majority of PCNSL patients who received corticosteroids before diagnosis did not experience significant radiographic change or require second biopsy for diagnosis.
Porter
Alyx B
AB
Department of Neurology, Mayo Clinic Rochester, Rochester MN, USA. porter.alyx@mayo.edu
Giannini
Caterina
C
Kaufmann
Timothy
T
Lucchinetti
Claudia F
CF
Wu
Wenting
W
Decker
Paul A
PA
Atkinson
John L D
JL
O'Neill
Brian Patrick
BP
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000368:Aged; D016477:Artifacts; D001921:Brain / Q000187:drug effects* / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D000305:Adrenal Cortex Hormones