title: [Delayed effect of exorphins on learning of albino rat pups].
abstract: The delayed effect of food-derived opioid peptides (exorphins) after chronic administration on postnatal days 1-14 on the learning of albino rat pups has been studied. Heptapeptide YPFPGPI (beta-casomorphin-7), pentapeptide YPLDL (rubiscolin-5) and pentapeptide YPISL (exorphin C) improved the development of the conditioned foraging reflex in a complex maze. Hexapeptide PFPGPI lacking the N-terminal tyrosine proved inefficient. Only beta-casomorphin-7 had an effect (negative) on passive avoidance conditioning. The obtained data confirm that exorphins (particularly, milk-derived beta-casomorphins) can have significant and long-term effects on the environmental adaptation of young mammals.
authors.forename: V A
authors.initials: VA
authors.lastname: Dubynin
authors.forename: I V
authors.initials: IV
authors.lastname: Malinovskaia
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Beliaeva
authors.forename: I S
authors.initials: IS
authors.lastname: Stovolosov
authors.forename: Zh D
authors.initials: ZhD
authors.lastname: Bespalova
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: A A
authors.initials: AA
authors.lastname: Kamenskiĭ
authors.forename: N F
authors.initials: NF
authors.lastname: Miasoedov
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D004723:Endorphins / Q000494:pharmacology*; D005260:Female; D006454:Hemoglobins / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects; D018847:Opioid Peptides / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D012273:Ribulose-Bisphosphate Carboxylase / Q000494:pharmacology*
chemical_list: D004723:Endorphins; D006454:Hemoglobins; D018847:Opioid Peptides; D010446:Peptide Fragments; C111722:exorphin C; C443992:rubiscolin 5; C041128:beta-casomorphin 7; D012273:Ribulose-Bisphosphate Carboxylase