Scaffold/matrix attachment regions (S/MARs): relevance for disease and therapy.
There is increasing awareness that processes, such as development, aging and cancer, are governed, to a considerable extent, by epigenetic processes, such as DNA and histone modifications. The sites of these modifications in turn reflect their position and role in the nuclear architecture. Since epigenetic changes are easier to reverse than mutations, drugs that remove or add the chemical tags are at the forefront of research for the treatment of cancerous and inflammatory diseases. This review will use selected examples to develop a unified view that might assist the systematic development of novel therapeutic regimens.
Gluch
A
A
Helmholtz-Zentrum für Infektionsforschung MBIO/Epigenetic Regulation, Inhoffenstrasse 7, Braunschweig, Germany.
Vidakovic
M
M
Bode
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D016503:Drug Delivery Systems; D015195:Drug Design; D044127:Epigenesis, Genetic / Q000502:physiology; D006801:Humans; D045170:Matrix Attachment Regions / Q000187:drug effects* / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology
D000970:Antineoplastic Agents; D004247:DNA