title: Hemophagocytic syndrome associated with hepatitis A: case report and literature review.
abstract: Virus-Associated Hemophagocytic Syndrome (VAHS) is a severe hematological disorder related to some viral infections. It is an illness characterized by persistent fever, pancytopenia, splenomegaly, hyperferritinemia and, the most important, hemophagocytosis observed in the bone marrow, liver and/or lymph nodes. VAHS associated with hepatitis A virus infection is rarely described, despite the high incidence of this viral infection in the population in general. There is no consensus in the literature regarding the optimal treatment of VAHS. In this article the clinical features, presumed pathogenesis, diagnostic criteria and treatment of VAHS are discussed, including description of cases of VAHS related to hepatitis A virus infection found in the medical literature.
authors.affiliation: Department of Infectious and Parasitic Diseases, University of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Felipe Francisco
authors.initials: FF
authors.lastname: Tuon
authors.forename: Virginia Soares
authors.initials: VS
authors.lastname: Gomes
authors.forename: Valdir Sabbaga
authors.initials: VS
authors.lastname: Amato
authors.forename: Maria Esther
authors.initials: ME
authors.lastname: Graf
authors.forename: Guilherme Henrique Hencklain
authors.initials: GH
authors.lastname: Fonseca
authors.forename: Carolina
authors.initials: C
authors.lastname: Lazari
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Nicodemo
mesh_terms: D000328:Adult; D005260:Female; D006506:Hepatitis A / Q000150:complications* / Q000175:diagnosis; D035922:Hepatitis A Antibodies / Q000097:blood; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*
chemical_list: D035922:Hepatitis A Antibodies; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors