Severe symptomatic hyponatremia during sibutramine therapy: a case report.
Sibutramine, a serotonin reuptake inhibitor, currently is used in treatment of obesity. The known side effects of sibutramine, ie, hypertension and tachycardia, depend on its adrenergic and serotoninergic effects. We describe a case of life-threatening hyponatremia associated with sibutramine use in an obese woman. We hypothesize that sibutramine, through its effect on neurotransmitters, may induce antidiuretic hormone secretion and lead to a syndrome of inappropriate antidiuretic hormone secretion. We advise careful monitoring of water-electrolytic balance during sibutramine therapy.
Esposito
Pasquale
P
Unit of Nephrology, Dialysis, and Transplantation, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy. pasqualeesposito@hotmail.com
Rampino
Teresa
T
Gregorini
Marilena
M
Soccio
Grazia
G
Piotti
Giovanni
G
Bedino
Giulia
G
Balenzano
Chiara Teresa
CT
Roscini
Elisabetta
E
Cosmai
Laura
L
Portalupi
Valentina
V
Libetta
Carmelo
C
Dal Canton
Antonio
A
D001067:Appetite Depressants / Q000008:administration & dosage / Q000009:adverse effects*; D015992:Body Mass Index; D003503:Cyclobutanes / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004636:Emergency Service, Hospital; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D007177:Inappropriate ADH Syndrome / Q000175:diagnosis; D008875:Middle Aged; D009767:Obesity, Morbid / Q000175:diagnosis / Q000188:drug therapy*; D018570:Risk Assessment; D012720:Severity of Illness Index
D001067:Appetite Depressants; D003503:Cyclobutanes; C058254:sibutramine