A case of mixed connective tissue disease complicated with hypertrophic obstructive cardiomyopathy.
A 54-year-old female was diagnosed as mixed connective tissue disease (MCTD) complicated with secondary Sjögren's syndrome. Although she had no dyspnea on exertion, the chest X-ray showed cardiomegaly with interstitial pneumonia. The echocardiogram demonstrated asymmetric hypertrophy of the interventricular septum. Diagnosis of hypertrophic obstructive cardiomyopathy (HOCM) was confirmed by left ventriculography and myocardial biopsy. She was treated with prednisolone, resulting in improvement of swollen hand, elevated muscle enzymes and interstitial pneumonia. A rare complication of HOCM with MCTD was described.
Nakamura
Hideki
H
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki City, Nagasaki 852-8501, Japan. nakamura_hideki911@yahoo.co.jp
Tateishi
Seiko
S
Kawakami
Atsushi
A
Ida
Hiroaki
H
Fukuda
Taku
T
Sasaki
Michiyo
M
Koide
Yuji
Y
Ashizawa
Naoto
N
Seto
Shinji
S
Hayashi
Tomayoshi
T
Sato
Shinichi
S
Eguchi
Katsumi
K
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D015804:HLA-DR4 Antigen / Q000276:immunology; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000209:etiology; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D012859:Sjogren's Syndrome / Q000150:complications* / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D015804:HLA-DR4 Antigen; D011239:Prednisolone