title: A Clinical Study of Photodynamic Therapy for Superficial Esophageal Carcinoma by YAG-OPO Laser.
abstract: A cooperative clinical study of photodynamic therapy (PDT) for superficial esophageal carcinoma was conducted at 6 medical institution. PHE (2mg/kg) with high tumor affinity was used as the oncotropic compound. The light source was a pulse wave YAG-OPO laser with high penetration into the tissue. Irradiation was performed at an energy density of 60-180 J/cm(2) 48-72 h after PHE administration. Eight lesions in 6 patients were treated. All were type 0-II superficial carcinomas. The depth of invasion was EP-MM for 6 lesions and SM for 2 lesions. A complete response (CR) was achieved in all patients after one session of PDT. Five adverse events, including anemia and fever, were reported by 4 patients, but all were WHO grade 2 or lower and transient. PDT using PHE and YAG-OPO laser was therefore considered effective as a curative therapy for superficial esophageal carcinoma.
authors.affiliation: Department of Gastrointestinal Endoscopy Tokyo Women's Medical College 8-1 Kawada-cho Shinjuku-ku Tokyo 162 Japan.
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authors.lastname: Yoshida
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authors.lastname: Suzuki
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authors.lastname: Mimura
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authors.lastname: Narahara
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authors.lastname: Tanimura
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authors.lastname: Nagai
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authors.lastname: Isono
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authors.lastname: Kozu
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authors.lastname: Fukutomi
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authors.lastname: Nakahara
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authors.lastname: Kashimura
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authors.lastname: Hirashima
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authors.lastname: Murata
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authors.lastname: Ide
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authors.lastname: Kato