title: Neuropsychologic outcomes in children with neonatal herpes encephalitis.
abstract: Neonatal herpes simplex virus infection with involvement of the central nervous system is a serious disease with high morbidity, even with acyclovir therapy. The disability includes cerebral palsy and different aspects of cognitive dysfunction which are of utmost importance for the child's future habilitation. We conducted a descriptive cohort study to define neuropsychologic outcomes and determine the relationship between neonatal neuroimaging and neuropsychologic outcomes. Among 267,690 children born in the Stockholm area over 12 years (1989-2000), 14 were diagnosed with neonatal herpes including central nervous system involvement. Nine children were neuropsychologically evaluated. Neonatal herpes virus infection had an even greater impact on cognitive function, speech ability, and attention deficit than anticipated. Relapse leading to deterioration was demonstrated in one child. Social skills were influenced to a lesser degree. Neurodevelopmental outcomes of the children were not well-correlated with extent of cerebral damage as visualized by computed tomography at 7-28 days after onset of signs. Neuropsychologic assessment is essential in the habilitation of the child, and a prerequisite for the evaluation of new treatments and for the assessment of deterioration of cerebral function related to relapses.
authors.affiliation: Division of Pediatrics, Department of Clinical Science, Intervention, and Technology, Karolinska University Hospital, Huddinge, Sweden. mona-lisa.engman@ki.se
authors.forename: Mona-Lisa
authors.initials: ML
authors.lastname: Engman
authors.forename: Ingrid
authors.initials: I
authors.lastname: Adolfsson
authors.forename: Ilona
authors.initials: I
authors.lastname: Lewensohn-Fuchs
authors.forename: Marianne
authors.initials: M
authors.lastname: Forsgren
authors.forename: Mikael
authors.initials: M
authors.lastname: Mosskin
authors.forename: Gunilla
authors.initials: G
authors.lastname: Malm
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002547:Cerebral Palsy / Q000209:etiology; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D015331:Cohort Studies; D020803:Encephalitis, Herpes Simplex / Q000473:pathology* / Q000523:psychology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D011247:Pregnancy; D011379:Prognosis; D013548:Sweden; D014057:Tomography, X-Ray Computed