Cyclins in meiosis: lost in translation.
In a recent issue of Cell, Carlile and Amon examine the regulation of four budding yeast B-type cyclins, crucial for regulating and distinguishing meoisis I and meoisis II divisions, and find a surprising diversity of behaviors and modes of regulation. In particular, Clb3 is regulated by a striking translational repression specific to meoisis I.
Futcher
Bruce
B
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA. bfutcher@ms.cc.sunysb.edu
D020121:5' Untranslated Regions; D000818:Animals; D015825:Chromosomes, Fungal / Q000378:metabolism; D016213:Cyclins / Q000378:metabolism*; D008540:Meiosis; D014176:Protein Biosynthesis; D012441:Saccharomyces cerevisiae / Q000166:cytology; D014981:Xenopus
D020121:5' Untranslated Regions; D016213:Cyclins