title: Ainsliadimer A, a new sesquiterpene lactone dimer with an unusual carbon skeleton from Ainsliaea macrocephala.
abstract: A phytochemical investigation of Ainsliaea macrocephala led to the isolation of a new dimeric sesquiterpene lactone, ainsliadimer A (1). The structure of 1 was elucidated by spectroscopic analysis, and confirmed by single crystal X-ray diffraction. Ainsliadimer A represents an unusual carbon skeleton with a cyclopentane system connecting the two monomeric sesquiterpene lactone units. This unique molecule exerted potent inhibitory activity against the production of nitric oxide in RAW264.7 stimulated by LPS.
authors.affiliation: Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai, PR China.
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Wu
authors.forename: Xi-Ke
authors.initials: XK
authors.lastname: Xu
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Juan
authors.initials: J
authors.lastname: Su
authors.forename: Jun-Mian
authors.initials: JM
authors.lastname: Tian
authors.forename: Shuang
authors.initials: S
authors.lastname: Liang
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Li
authors.forename: Rui-Hui
authors.initials: RH
authors.lastname: Liu
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D007783:Lactones; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; C530462:ainsliadimer A; D009569:Nitric Oxide