title: The relationship of 3-PBA pyrethroids metabolite and male reproductive hormones among non-occupational exposure males.
abstract: Many pesticides possess hormonal activities and have been classified as endocrine disrupting chemicals. Synthetic pyrethroids are one kind of the most common pesticides used in the world. In the present study, we explored the association between serum reproductive hormone levels and urinary creatine (CR) adjusted concentration of 3-phenoxybenzoic acid (3-PBA), a general metabolite of pyrethroids, in Chinese adult men. The study subjects (n=212) were from the affiliated hospitals of Nanjing Medical University. By using GC-MS, urinary 3-PBA level of each subject was measured and adjusted by urinary CR. Blood samples were collected for measuring the serum levels of reproductive hormones, including follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T) and prolactin (PRL). All the subjects had detectable levels of 3-PBA in their urine samples. The median concentration of 3-PBA was 0.815 microg g (-1)of CR. The results showed that there was positive associations between the levels of serum LH and 3-PBA (p=0.013) but negative associations between E2 and 3-PBA level (p=0.022), and the adjusting p-value was 0.044 for LH and E2, which suggested that pyrethroids are capable of disrupting the male endocrine function. In adult men, urinary 3-PBA levels were associated with increased LH and reduced E2 levels. On a population level, these reductions show potential public health importance because of widespread exposure to these pesticides.
authors.affiliation: Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Han
authors.forename: Yankai
authors.initials: Y
authors.lastname: Xia
authors.forename: Jiayuan
authors.initials: J
authors.lastname: Han
authors.forename: Jinping
authors.initials: J
authors.lastname: Zhou
authors.forename: Shoulin
authors.initials: S
authors.lastname: Wang
authors.forename: Pengfei
authors.initials: P
authors.lastname: Zhu
authors.forename: Rencheng
authors.initials: R
authors.lastname: Zhao
authors.forename: Nianzu
authors.initials: N
authors.lastname: Jin
authors.forename: Ling
authors.initials: L
authors.lastname: Song
authors.forename: Xinru
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D001565:Benzoates / Q000097:blood* / Q000652:urine; D003401:Creatine / Q000652:urine; D004781:Environmental Exposure; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007306:Insecticides / Q000097:blood* / Q000652:urine; D008019:Life Style; D008297:Male; D009790:Occupations; D010573:Pesticide Residues / Q000097:blood* / Q000652:urine; D011722:Pyrethrins / Q000097:blood* / Q000652:urine
chemical_list: D001565:Benzoates; D012739:Gonadal Steroid Hormones; D007306:Insecticides; D010573:Pesticide Residues; D011722:Pyrethrins; C017618:3-phenoxybenzoic acid; D003401:Creatine