Poly(amidosulfonic acid) modified glassy carbon electrode for determination of isoniazid in pharmaceuticals.
Amidosulfonic acid was electropolymerized by cyclic voltammetry onto the surface of glassy carbon electrode (GCE) to fabricate the chemically modified electrode, which showed high stability, good selectivity and reproducibility for determination of isoniazid. The modified electrode showed an excellent electrocatalytical effect on the oxidation of isoniazid. Under the optimum conditions, there was a good linear relationship between anodic peak current and isoniazid concentration in the range of 5.0 x 10(-8)- 1.0 x 10(-5) M, and a detection limit of 1.0 x 10(-8) M (S/N = 3) was obtained after 120 s at the accumulation potential of - 0.2 V (vs. SCE). This developed method had been applied to the direct determination of isoniazid in injection and tablet samples with satisfactory results.
Yang
Gongjun
G
College of Chemistry and Engineering, Yangzhou University, Yangzhou, PR China. yanggongjun888@163.com
Wang
Cunxiao
C
Zhang
Rui
R
Wang
Chenying
C
Qu
Qishu
Q
Hu
Xiaoya
X
D002138:Calibration; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D004563:Electrochemistry; D004566:Electrodes; D005898:Glass / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007538:Isoniazid / Q000032:analysis* / Q000737:chemistry*; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D015203:Reproducibility of Results; D013451:Sulfonic Acids / Q000737:chemistry*; D013499:Surface Properties
D004364:Pharmaceutical Preparations; D013451:Sulfonic Acids; C531175:poly(amidosulfonic acid); D002244:Carbon; C005741:sulfamic acid; D007538:Isoniazid