title: Effect of natural early menopause on bone mineral density.
abstract: OBJECTIVE
  Early menopause (EM) is included among the risk factors for osteoporosis. Several studies have shown that women with early menopause have lower bone mineral density (BMD) than those with normal expected age of menopause. The aim of our cross-sectional study was to investigate the effects of time of menopause on vertebral bone mass in healthy postmenopausal women and to evaluate if early menopause is a risk factor for lower vertebral BMD.
  
  
  METHODS
  We studied 782 who had never received drugs acting on bone mass. The study population was divided into three groups: women with early, normal (NM), and late (LM) menopause. Our study population was further categorized in 5-year age segments between 45 and >75.
  
  
  RESULTS
  The three groups examined did not differ for age, age at menarche, body mass index (BMI), and vertebral BMD, while there were significant differences in age at menopause and years since menopause. Our study showed that women with EM presented significantly lower vertebral BMD than NM and LM in 50-54 age segments. Beyond 55 years, EM, NM, and LM women had no differences in lumbar BMD values.
  
  
  CONCLUSIONS
  In conclusion, controversial data demonstrated that the absolute amount of bone loss is greater after early menopause than after normal or late menopause, even if a slight effect of early menopause on bone mass cannot be excluded.
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Polytechnic University of Marche, Ancona, Italy. cm.francucci@ao-umbertoprimo.marche.it
authors.forename: C M
authors.initials: CM
authors.lastname: Francucci
authors.forename: P
authors.initials: P
authors.lastname: Romagni
authors.forename: A
authors.initials: A
authors.lastname: Camilletti
authors.forename: P
authors.initials: P
authors.lastname: Fiscaletti
authors.forename: L
authors.initials: L
authors.lastname: Amoroso
authors.forename: G
authors.initials: G
authors.lastname: Cenci
authors.forename: C
authors.initials: C
authors.lastname: Morbidelli
authors.forename: M
authors.initials: M
authors.lastname: Boscaro
mesh_terms: D000368:Aged; D000375:Aging; D015519:Bone Density / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008594:Menopause, Premature / Q000502:physiology*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology*; D013997:Time Factors