Interleukin-12 receptor beta1 polymorphisms and nontuberculous mycobacterial lung diseases.
The pathway involving interferon-gamma and interleukin (IL)-12 plays an important role in host defense against mycobacterial infections. Recent studies have indicated that IL-12 receptor beta1 (IL-12Rbeta1) gene polymorphisms are associated with susceptibility to pulmonary tuberculosis. However, there have been no reports of an association between IL-12Rbeta1 gene polymorphism and lung disease caused by nontuberculous mycobacteria (NTM). The present study involved 128 patients with the nodular bronchiectatic form of NTM lung disease (75 patients with Mycobacterium avium-intracellulare complex infection and 53 patients with Mycobacterium abscessus infection) and 240 healthy controls. Single nucleotide polymorphisms of the IL-12Rbeta1 gene at positions +705A/G, +1158T/C, and +1196G/C were determined by direct sequencing of polymerase chain reaction products. Comparisons of the NTM lung disease patients with healthy controls did not identify any significant differences in relation to the genotype, allele, and haplotype frequencies of the IL-12Rbeta1 +705A/G, +1158T/C, and +1196G/C polymorphisms. These IL-12Rbeta1 gene polymorphisms do not appear to be responsible for host susceptibility to NTM lung disease, at least in this Korean population.
Park
Hye Yun
HY
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea.
Kwon
Yong Soo
YS
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea.
Ki
Chang-Seok
CS
Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Suh
Gee Young
GY
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea.
Chung
Man Pyo
MP
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea.
Kim
Hojoong
H
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea.
Kwon
O Jung
OJ
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea.
Koh
Won-Jung
WJ
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea. wjkoh@skku.edu.
D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008171:Lung Diseases / Q000208:ethnology / Q000235:genetics* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000208:ethnology / Q000235:genetics* / Q000382:microbiology; D015270:Mycobacterium avium-intracellulare Infection / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D053707:Receptors, Interleukin-12 / Q000235:genetics*
C508438:IL12RB1 protein, human; D053707:Receptors, Interleukin-12