title: Computational design and discovery of conformationally flexible inhibitors of acetohydroxyacid synthase to overcome drug resistance associated with the W586L mutation.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, PR China.
authors.forename: Feng-Qin
authors.initials: FQ
authors.lastname: Ji
authors.forename: Cong-Wei
authors.initials: CW
authors.lastname: Niu
authors.forename: Chao-Nan
authors.initials: CN
authors.lastname: Chen
authors.forename: Qiong
authors.initials: Q
authors.lastname: Chen
authors.forename: Guang-Fu
authors.initials: GF
authors.lastname: Yang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Xi
authors.forename: Chang-Guo
authors.initials: CG
authors.lastname: Zhan
mesh_terms: D000095:Acetolactate Synthase / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D019295:Computational Biology; D015195:Drug Design; D004351:Drug Resistance / Q000187:drug effects* / Q000235:genetics*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D007700:Kinetics; D007930:Leucine / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D008968:Molecular Conformation; D009154:Mutation / Q000235:genetics; D014364:Tryptophan / Q000235:genetics / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D014364:Tryptophan; D000095:Acetolactate Synthase; D007930:Leucine