Solubilisation de filtres-UV dans des melanges ternaires de phases apolaires, optimisation par l'utilisation de reseaux centres.
This paper is concerned with the solubility of UV filters. Emulsions are perfect formulations used for sunscreens, but to give the skin silky feel without being greasy, the oily phase content is low. Considerations of sunscreen solubility can help to solve specific problems of stability in formulations. It is important to determine what solvent dissolves them and what mixture of solvent improves their solubility. Two water insoluble sunscreens were tested at several concentrations in various non-polar solvents. A strategy with simplex centroid design was used to optimize this work. The graphical interpretation of the data assists our understanding of the solubility of UV filters.
Marti-Mestres
G
G
Laboratoire de Technique Pharmaceutique Industrielle, Faculte de Pharmacie, Av. Ch. Flahault. 34060 Montpellier Cedex, France.
Laget
J P
JP
Maillols
H
H
Fernandez
C
C