Temporary inactivation of dorsal hippocampus attenuates explicitly nonspatial, unimodal, contextual fear conditioning.
The current study examined the effects of temporary inactivation of the DH on freezing, rearing, ambulating, grooming, and whisking behavior in an explicitly nonspatial contextual fear conditioning paradigm in which olfactory stimuli served as temporally and spatially diffuse contexts. Prior either to training, testing, or both, male Sprague-Dawley rats received bilateral microinfusions of saline or the GABA(A) agonist muscimol into the DH. Results indicate that temporary inactivation of DH produced both anterograde and retrograde deficits in contextually conditioned freezing, while sparing the acquisition and expression of freezing to a discrete auditory or olfactory CS. These data suggest that there is a decidedly nonspatial component to the role of DH in contextual conditioning, and that olfactory contextual conditioning is a fruitful means of further exploring this function.
Parsons
Teresa Camille
TC
Program in Behavioral Neuroscience, Department of Psychology, Rutgers, The State University of New Jersey, New Brunswick, NJ 08903, USA.
Otto
Tim
T
D000161:Acoustic Stimulation; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D005239:Fear / Q000502:physiology*; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects / Q000502:physiology*; D018755:GABA Agonists / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D009812:Odorants; D051381:Rats; D017207:Rats, Sprague-Dawley; D012903:Smell / Q000502:physiology; D013028:Space Perception / Q000187:drug effects / Q000502:physiology
D018755:GABA Agonists; D009118:Muscimol