title: Double-blind, multicenter, prospective randomized study of trospectomycin vs. Clindamycin, both with aztreonam, in non-community acquired obstetric and gynecologic infections.
abstract: OBJECTIVE
  The purpose of this study was to compare the clinical efficacy and safety of trospectomycin sulfate with that of clindamycin phosphate, both with aztreonam, for the treatment of obstetric and gynecologic infections.
  
  
  METHODS
  In a double-blind, multicenter, prospective randomized study, 579 patients with either endometritis following cesarean delivery or pelvic cellulitis following hysterectomy were enrolled and received medication. Administered was either trospectomycin sulfate 500 mg IV every 8 h or clindamycin phosphate 900 mg IV every 8 h in a 1:1 randomization ratio. Both groups of patients received aztreonam 1 g IV every 8 h. The patients were followed for clinical responses and side effects.
  
  
  RESULTS
  The cure rate for the trospectomycin sulfate arm was 91.8% and for clindamycin phosphate arm it was 88.4% (P = 0.218). The adverse events were similar in both groups.
  
  
  CONCLUSIONS
  Trospectomycin was as effective as clindamycin, when both were combined with aztreonam, in treatment of obstetric and gynecologic infections.
authors.affiliation: Department of Obstetrics and Gynecology Temple University School of Medicine Philadelphia PA USA.
authors.forename: A
authors.initials: A
authors.lastname: Chatwani
authors.forename: M
authors.initials: M
authors.lastname: Martens
authors.forename: J
authors.initials: J
authors.lastname: Blanco
authors.forename: S
authors.initials: S
authors.lastname: Gall
authors.forename: K
authors.initials: K
authors.lastname: Przybylko
authors.forename: C P
authors.initials: CP
authors.lastname: Wajszczuk
authors.forename: D
authors.initials: D
authors.lastname: Nickens