title: [Application of flurbiprofen preemptive analgesia combined with intravenous propofol anesthesia in induced abortion].
abstract: OBJECTIVE
  To investigate the effect of flurbiprofen preemptive analgesia combined with intravenous propofol anesthesia in induced abortion.
  
  
  METHODS
  Totally 175 women (ASA class I) undergoing induced abortion were randomized into 5 groups. In K10, K5, and K1 groups, the patients were given 50 mg flurbiprofen 10, 5 and 1 min before the operation, respectively, and in F group, 1 microg/kg of fentanyl was administered 10 min before the operation. All the 4 groups had intravenous induction with 2 mg/kg propofo1. The patients in P group received propofol at 2 mg/kg as the control group. The heart rate (HR), mean arterial pressure (MAP) and SpO2 were monitored during the operation, and the induction time, recovery time, propofol dosage and adverse effect were recorded. The anesthetic effect of the protocols was assessed according to the visual analogue scale (VAS) and the overall patient satisfaction.
  
  
  RESULTS
  HR, MAP, propofol consumption and the incidences of adverse effects during the operation were significantly higher in P group than in the other groups. F group had the highest incidence of respiratory depression among the 5 groups. The VAS in K10 group was significantly lower than that in K5 and K1 groups (P<0.05), but similar to that in F group (P>0.05). The overall patients' satisfaction was significantly higher than that in the other 4 groups.
  
  
  CONCLUSIONS
  Flurbiprofen preemptive analgesia combined with intravenous propofol is safe and effective for anesthesia during induced abortion.
authors.affiliation: Department of Anesthesiology, Guangzhou Women and Children's Hospital, Guangzhou 510180, China. losonlao@hotmail.com
authors.forename: Wen-xing
authors.initials: WX
authors.lastname: Liu
authors.forename: Yong-fu
authors.initials: YF
authors.lastname: Zhang
authors.forename: Shu-xia
authors.initials: SX
authors.lastname: Tan
authors.forename: Jian-xin
authors.initials: JX
authors.lastname: Lao
mesh_terms: D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use; D000758:Anesthesia / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015742:Propofol / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D018686:Anesthetics, Intravenous; D005480:Flurbiprofen; D015742:Propofol