title: Rapid molecular cytogenetic diagnosis of transfusion associated graft-versus-host disease by fluorescent in situ hybridization (FISH).
abstract: Transfusion associated graft-versus-host disease (TA-GVHD) is a rare, dreadful complication of transfusion in immunocompromized and immunologically competent individuals. The diagnosis is often delayed, because of lack of awareness and the non-specific clinical features. We describe a rapid molecular cytogenetic analysis of FISH for the diagnosis of two cases of TA-GVHD with sex-mismatched donors. The use of FISH is a rapid and sensitive technique for the early diagnosis of TA-GVHD when the recipient and donor are of different gender.
authors.affiliation: Department of Hematology, Eskişehir Osmangazi University Medical School, Eskisehir, Turkey. melhak@hotmail.com
authors.forename: Meltem O
authors.initials: MO
authors.lastname: Akay
authors.forename: Gokhan
authors.initials: G
authors.lastname: Temiz
authors.forename: Hava U
authors.initials: HU
authors.lastname: Teke
authors.forename: Eren
authors.initials: E
authors.lastname: Gunduz
authors.forename: Mustafa F
authors.initials: MF
authors.lastname: Acikalin
authors.forename: Serap
authors.initials: S
authors.lastname: Isiksoy
authors.forename: Beyhan
authors.initials: B
authors.lastname: Durak
authors.forename: Zafer
authors.initials: Z
authors.lastname: Gulbas
mesh_terms: D000368:Aged; D017707:Erythrocyte Transfusion; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D012680:Sensitivity and Specificity