title: Default mode network as revealed with multiple methods for resting-state functional MRI analysis.
abstract: Recently, human brain activity during a resting-state has attracted increasing attention. Several studies have found that there are two networks: the default mode network and its anti-correlation network. Some studies have subsequently showed that the functions of brain areas within the default mode network are crucial in human mental activity. To further discern the brain default mode network as well as its anti-correlation network during resting-state, we used three methods to analyze resting-state functional magnetic resonance imaging (fMRI) data; regional homogeneity analysis, linear correlation and independent component analysis, on four groups of dataset. Our results showed the existence of these two networks prominently and consistently during a resting- and conscious-state across the three methods. This consistency was exhibited in four independent groups of normal adults. Moreover, the current results provided evidences that the brain areas within the two anti-correlated networks are highly integrated at both the intra- and inter-regional level.
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.
authors.forename: Xiang-Yu
authors.initials: XY
authors.lastname: Long
authors.forename: Xi-Nian
authors.initials: XN
authors.lastname: Zuo
authors.forename: Vesa
authors.initials: V
authors.lastname: Kiviniemi
authors.forename: Yihong
authors.initials: Y
authors.lastname: Yang
authors.forename: Qi-Hong
authors.initials: QH
authors.lastname: Zou
authors.forename: Chao-Zhe
authors.initials: CZ
authors.lastname: Zhu
authors.forename: Tian-Zi
authors.initials: TZ
authors.lastname: Jiang
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Qi-Yong
authors.initials: QY
authors.lastname: Gong
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Kun-Cheng
authors.initials: KC
authors.lastname: Li
authors.forename: Sheng
authors.initials: S
authors.lastname: Xie
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Zang
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000502:physiology; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D016571:Neural Networks, Computer; D010100:Oxygen / Q000097:blood; D025341:Principal Component Analysis; D012146:Rest / Q000502:physiology*
chemical_list: D010100:Oxygen