title: Low-grade chronic inflammation is not accompanied by structural arterial injury in polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate the presence of premature subclinical atherosclerosis, measured by examining carotid intima-media thickness (IMT) and to investigate whether the IMT may be linked to low-grade chronic inflammation, assessed by C-reactive protein (CRP), in young women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Fifty seven PCOS patients and 37 similarly aged and weight controls underwent B-mode ultrasonography of the carotid arteries for IMT measure. All these women were also screened for CRP and metabolic parameters including fasting insulin, glucose, lipid and androgen levels. Differences between means were analyzed by Student's unpaired t-test and analysis of correlations between parameters was performed by using Pearson's correlation.
  
  
  RESULTS
  CRP was significantly higher in PCOS patients than in controls (3.1mg/dL vs. 1.4mg/dL; p=0.004). No difference was noted in IMT mean between PCOS cases and controls (0.52mm vs. 0.53mm; p=0.35). IMT did not correlate with CRP but exhibited a significant positive correlation with total testosterone (r=0.72, p=0.01).
  
  
  CONCLUSIONS
  This study suggests that PCOS itself is not associated with structural arterial injury, carotid IMT is not linked to low-grade chronic inflammation and hyperandrogenism may be associated with subclinical atherosclerosis and cardiovascular risk in young women with PCOS. Additional research is needed to clarify these findings.
authors.affiliation: Division of Gynecological Endocrinology and Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Pernambuco, Recife, Brazil. heliolaura@yahoo.com.br
authors.forename: Laura Olinda Bregieiro Fernandes
authors.initials: LO
authors.lastname: Costa
authors.forename: Mayra Pereira
authors.initials: MP
authors.lastname: dos Santos
authors.forename: Mônica
authors.initials: M
authors.lastname: Oliveira
authors.forename: Aline
authors.initials: A
authors.lastname: Viana
mesh_terms: D000293:Adolescent; D000328:Adult; D001158:Arteries / Q000293:injuries / Q000473:pathology*; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000453:epidemiology*; D011085:Polycystic Ovary Syndrome / Q000473:pathology / Q000503:physiopathology*; D012016:Reference Values
chemical_list: D002097:C-Reactive Protein