Common sequence variants on 20q11.22 confer melanoma susceptibility.
We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.
Brown
Kevin M
KM
Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85028, USA.
Macgregor
Stuart
S
Montgomery
Grant W
GW
Craig
David W
DW
Zhao
Zhen Zhen
ZZ
Iyadurai
Kelly
K
Henders
Anjali K
AK
Homer
Nils
N
Campbell
Megan J
MJ
Stark
Mitchell
M
Thomas
Shane
S
Schmid
Helen
H
Holland
Elizabeth A
EA
Gillanders
Elizabeth M
EM
Duffy
David L
DL
Maskiell
Judith A
JA
Jetann
Jodie
J
Ferguson
Megan
M
Stephan
Dietrich A
DA
Cust
Anne E
AE
Whiteman
David
D
Green
Adele
A
Olsson
Håkan
H
Puig
Susana
S
Ghiorzo
Paola
P
Hansson
Johan
J
Demenais
Florence
F
Goldstein
Alisa M
AM
Gruis
Nelleke A
NA
Elder
David E
DE
Bishop
Julia Newton
JN
Kefford
Richard F
RF
Giles
Graham G
GG
Armstrong
Bruce K
BK
Aitken
Joanne F
JF
Hopper
John L
JL
Martin
Nicholas G
NG
Trent
Jeffrey M
JM
Mann
Graham J
GJ
Hayward
Nicholas K
NK
D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D002890:Chromosomes, Human, Pair 20; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008545:Melanoma / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012878:Skin Neoplasms / Q000235:genetics*