Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review.
The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/index.html ). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The meta-analysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-ORm2/m2: 1.9, 95% confidence interval: 1.4-2.7; Pooled ORm2m2: 2.0, 95% confidence interval: 1.3-3.1; ORm1m2 or [infi]m2m2: 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (ORVal/Val: 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer.
Varela-Lema
Leonor
L
Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, Spain.
Taioli
Emanuela
E
Ruano-Ravina
Alberto
A
Barros-Dios
Juan M
JM
Anantharaman
Devasena
D
Benhamou
Simone
S
Boccia
Stefania
S
Bhisey
Rajani A
RA
Cadoni
Gabriella
G
Capoluongo
Ettore
E
Chen
Chien-Jen
CJ
Foulkes
William
W
Goloni-Bertollo
Eny Maria
EM
Hatagima
Ana
A
Hayes
Richard B
RB
Katoh
Takahiko
T
Koifman
Sergio
S
Lazarus
Phillip
P
Manni
Johannes J
JJ
Mahimkar
Manoj
M
Morita
Shunji
S
Park
Jong
J
Park
Kwang-Kyun
KK
Pavarino Bertelli
Erika Cristina
EC
de Souza Fonseca Ribeiro
Enilze Maria
EM
Roy
Bidyut
B
Spitz
Margaret R
MR
Strange
Richard C
RC
Wei
Qingyi
Q
Ragin
Camille C
CC
D000483:Alleles; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005091:Exons; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D009062:Mouth Neoplasms / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D010610:Pharyngeal Neoplasms / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D014029:Tobacco Use Disorder / Q000150:complications
D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase