[Effects of an antiischemic drug combination and nimodipine on cerebral blood supply in a hemorrhagic stroke model in rats].
Narcotized rats with a hemorrhagic stroke model demonstrate a significant decrease in the cerebral flow in the area of contralateral cerebral hemisphere symmetric to the zone of lesion. Under these conditions, an antiischemic drug combination produced a pronounced but short increase in the local circulation in cortex of cerebrum (decreased by hemorrhagic stroke), with the subsequent decrease in the local flow. Nimodipine (used as the reference drug) increased the cerebral blood flow to a lesser degree, but was superior to the tested composition with respect to the effect duration.
Mirzoian
N R
NR
Gan'shina
T S
TS
Kurdiumov
I N
IN
Bero
R S
RS
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004338:Drug Combinations; D020300:Intracranial Hemorrhages / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D009553:Nimodipine / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000494:pharmacology*; D051381:Rats
D002121:Calcium Channel Blockers; D004338:Drug Combinations; D011760:Pyrrolidinones; D009553:Nimodipine; D011761:Pyrrolidonecarboxylic Acid