Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction.
BACKGROUND
This study was designed to investigate the association of the 894G>T polymorphism in the eNOS gene with risk of acute myocardial infarction (AMI), extent of coronary artery disease (CAD) on coronary angiography, and in-hospital mortality after AMI.


METHODS
We studied 1602 consecutive patients who were enrolled in the GEMIG study. The control group was comprised by 727 individuals, who were randomly selected from the general adult population.


RESULTS
The prevalence of the Asp298 variant of eNOS was not found to be significantly and independently associated with risk of AMI (RR = 1.08, 95%CI = 0.77-1.51, P = 0.663), extent of CAD on angiography (OR = 1.18, 95%CI = 0.63-2.23, P = 0.605) and in-hospital mortality (RR = 1.08, 95%CI = 0.29-4.04, P = 0.908).


CONCLUSIONS
In contrast to previous reports, homozygosity for the Asp298 variant of the 894G>T polymorphism in the eNOS gene was not found to be associated with risk of AMI, extent of CAD and in-hospital mortality after AMI.
Andrikopoulos
George K
GK
1st Cardiac Department, Evaggelismos Hospital, Athens, Greece. gkandrik@otenet.gr
Grammatopoulos
Dimitris K
DK
Tzeis
Stylianos E
SE
Zervou
Sevasti I
SI
Richter
Dimitris J
DJ
Zairis
Michalis N
MN
Gialafos
Elias J
EJ
Sakellariou
Dimitris C
DC
Foussas
Stefanos G
SG
Manolis
Antonis S
AS
Stefanadis
Christodoulos I
CI
Toutouzas
Pavlos K
PK
Hillhouse
Edward W
EW
D000328:Adult; D000368:Aged; D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000201:enzymology / Q000209:etiology / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D005091:Exons; D005260:Female; D006115:Greece / Q000453:epidemiology; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology* / Q000209:etiology / Q000235:genetics* / Q000401:mortality; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D017931:DNA Primers; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III