Update on thyroid cancer.
With over 2 000 articles published on thyroid cancer between January 1, 2006 and September 10, 2007 it is difficult to offer an updated and complete review on this malignancy. Thus, I elected to summarize papers published in 2007 on topics frequently overlooked in other reviews or books, and papers that are likely to be followed by interesting developments. Papers include: 1) the accuracy and currency of websites on thyroid cancer; 2) the detection of the V600E BRAF mutation in very small papillary thyroid cancers that are detected histologically; 3) the relationship between thyroid cancer and Hashimoto's thyroiditis or hepatitis C virus, an association that appears to be nonrandom; 4) the not negligible frequency of coexistence of thyroid cancer with primary hyperparathyroidism; 5) the value of ultrasound elastography of thyroid nodules in distinguishing malignant form benign lesions; 6) the value of percutaneous ethanol injection in the treatment of thyroid or nodal recurrences of thyroid cancer; 7) the relatively benign course of intrathyroid metastases from renal cell carcinoma; 8) the exceedingly rare thyroid paraganglioma, though the rate of reports has increased recently; and 9) the increase in serum calcitonin caused by chronic alcoholism, an increase that cannot be reversed by three weeks of alcohol weaning.
Benvenga
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Programma di Endocrinologia Molecolare Clinica, AOU Policlinico G. Martino, Messina, Italy. sbenvenga@me.nettuno.it
D000437:Alcoholism; D019943:Amino Acid Substitution; D002908:Chronic Disease; D050031:Hashimoto Disease; D016174:Hepacivirus; D006801:Humans; D020407:Internet; D020125:Mutation, Missense; D010506:Periodicals as Topic; D048493:Proto-Oncogene Proteins B-raf; D013964:Thyroid Neoplasms
C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf