title: In vitro hepatoprotective compounds from Suaeda glauca.
abstract: Bioassay-guided fractionation of the MeOH extract of Suaeda glauca yielded four phenolic compounds, methyl 3,5-di-O-caffeoyl quinate (1) and 3,5-di-O-caffeoyl quinic acid (2), isorhamnetin 3-O-beta-D-galactoside (3), and quercetin 3-O-beta-D-galactoside (4). Compounds 1 and 2 were hepatoprotective against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells with the EC(50) values of 72.7+/-6.2 and 117.2+/-10.5 microM, respectively. Silybin as a positive control showed an EC(50) value of 82.4+/-4.1 microM.
authors.affiliation: College of Pharmacy, Yanbian University, Yanji, Jilin, 133000, China.
authors.forename: Ren-Bo
authors.initials: RB
authors.lastname: An
authors.forename: Dong-Hwan
authors.initials: DH
authors.lastname: Sohn
authors.forename: Gil-Saeng
authors.initials: GS
authors.lastname: Jeong
authors.forename: Youn-Chul
authors.initials: YC
authors.lastname: Kim
mesh_terms: D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor; D019663:Chenopodiaceae; D002726:Chlorogenic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D008113:Liver Neoplasms; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D013619:Tacrine / Q000633:toxicity
chemical_list: C525762:3,5-dicaffeoylquinic acid methyl ester; D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D002726:Chlorogenic Acid; D013619:Tacrine; C100434:3,5-dicaffeoylquinic acid