title: 5-HT2C receptor and MAO-A interaction analysis: no association with suicidal behaviour in bipolar patients.
abstract: The serotonin 2C (HTR2C) receptor has been implicated in suicide-related behaviours, however there are not many studies to date about HTR2C and suicidality. We studied HTR2C haplotypes in suicide attempters, where our sample composed of 306 families with at least one member affected by bipolar disorder. HTR2C (Cys23Ser and a common STR in the promoter) variants were analyzed with respect to attempter status and the severity of suicidal behaviour. The X-linked haplotype analysis in relation to suicide attempt did not reveal any significant association. Furthermore, we performed a particular gene-gene interaction for the X-linked serotonergic genes (HTR2C and MAOA), and found no association among this intergenic haplotype combination and suicidal behaviour in bipolar disorder.
authors.affiliation: Dept. of Psychiatry, University of Toronto, 250 College Street, R-30, Toronto (ON), Canada M5T 1R8. vincenzo_deluca@camh.net
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Luca
authors.forename: Subi
authors.initials: S
authors.lastname: Tharmaligam
authors.forename: John
authors.initials: J
authors.lastname: Strauss
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology; D002170:Canada; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D050172:Genes, X-Linked; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D009679:Nuclear Family; D020641:Polymorphism, Single Nucleotide; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics*; D013406:Suicide, Attempted / Q000523:psychology*; D055815:Young Adult
chemical_list: D044405:Receptor, Serotonin, 5-HT2C; D008995:Monoamine Oxidase