Time-dependent effect of low-frequency stimulation on amygdaloid-kindling seizures in rats.
Low-frequency stimulation (LFS) has been considered as a new option for the treatment of intractable epilepsy. The present study was designed to determine whether LFS of the kindling focus given at different time points after seizures exert different roles on kindling seizures. Our results showed that: (i) In kindling animals, LFS delivered immediately after cessation of the kindling stimulus inhibited the seizure stage during kindling acquisition, whereas LFS delivered after the cessation of afterdischarge accelerated the kindling progression to stages 1 and 2. (ii) In fully kindled animals, when using the generalized seizure threshold current as the kindling stimulus, immediate LFS decreased the incidence of generalized seizures and the average seizure stage as well as shortened the cumulative generalized seizure duration (GSD). However, delayed LFS prolonged the cumulative GSD and afterdischarge duration. Our study indicates that there is a time-dependent aspect of LFS treatment, and immediate LFS has anti-epileptogenic action.
Wu
Deng-Chang
DC
Department of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, 388 Yuhang Tang Road, Hangzhou 310058, PR China.
Xu
Zheng-Hao
ZH
Wang
Shuang
S
Fang
Qi
Q
Hu
Dan-Qing
DQ
Li
Qing
Q
Sun
Hong-Liu
HL
Zhang
Shi-Hong
SH
Chen
Zhong
Z
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation / Q000379:methods*; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000209:etiology*; D013995:Time