Effect of Tectona grandis on phenylhydrazine-induced anaemia in rats.
Traditional oral report indicates that Tectona grandis is used in the treatment of anaemia in Togo. For this purpose, the extract of T. grandis leaves is evaluated on anaemia model of rat induced by intraperitoneal injection of phenylhydrazine at 40 mg/kg for 2 days. Oral administration of T. grandis extract at 1 g/kg/day and 2 g/kg/day, to the rats previously treated with phenylhydrazine, increased the concentration of haemoglobin, red blood cells number, haematocrit and reticulocytes rate. Moreover, the extract of T. grandis enhanced the osmotic resistance of the red blood cells that confirm the important presence of young red blood cells. These results support partially the traditional use of T. grandis in the treatment of anaemia.
Diallo
Aboudoulatif
A
Laboratoire de Physiologie/Pharmacologie, Faculté des Sciences Université de Lomé, Togo. aboudoulatif@yahoo.fr
Gbeassor
Messanvi
M
Vovor
Ahoefa
A
Eklu-Gadegbeku
Kwashie
K
Aklikokou
Kodjo
K
Agbonon
Amegnona
A
Abena
Ange A
AA
de Souza
Comla
C
Akpagana
Koffi
K
D000740:Anemia / Q000139:chemically induced* / Q000188:drug therapy*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D019686:Lamiaceae / Q000737:chemistry*; D008297:Male; D010659:Phenylhydrazines / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D006454:Hemoglobins; D010659:Phenylhydrazines; D010936:Plant Extracts; C030299:phenylhydrazine