title: Combined effect of gender and caloric restriction on liver proteomic expression profile.
abstract: We analyzed the combined effect of gender and CR on protein expression profile in liver. We identified 27 differentially expressed proteins involved in several cellular functions such as substrate metabolism, antioxidant systems, stress response, iron homeostasis and cardiovascular protection. This study reveals new cellular pathways liable to be similarly regulated in females and calorie restricted rats and which could be related with the greater longevity in these animals.
authors.affiliation: Grup de Metabolisme Energetic i Nutricio, Departament de Biologia Fonamental i Ciencies de la Salut, Institut Universitari d'Investigacio en Ciencies de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain. vdbsavg4@uib.es
authors.forename: Adamo
authors.initials: A
authors.lastname: Valle
authors.forename: Elena
authors.initials: E
authors.lastname: Silvestri
authors.forename: Maria
authors.initials: M
authors.lastname: Moreno
authors.forename: Angela
authors.initials: A
authors.lastname: Chambery
authors.forename: Jordi
authors.initials: J
authors.lastname: Oliver
authors.forename: Pilar
authors.initials: P
authors.lastname: Roca
authors.forename: Fernando
authors.initials: F
authors.lastname: Goglia
mesh_terms: D000818:Animals; D001835:Body Weight; D031204:Caloric Restriction; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D020869:Gene Expression Profiling; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism*; D008136:Longevity; D008297:Male; D009929:Organ Size; D020543:Proteome / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D020543:Proteome