title: Coagulation activity before and after acute psychosocial stress increases with age.
abstract: OBJECTIVE
  To assess whether stress further increases hypercoagulation in older individuals. We investigated whether acute stress-induced changes in coagulation parameters differ with age. It is known that hypercoagulation occurs in response to acute stress and that a shift in hemostasis toward a hypercoagulability state occurs with age. However, it is not yet known whether acute stress further increases hypercoagulation in older individuals, and thus may increase their risk for cardiovascular disease (CVD).
  
  
  METHODS
  A total of 63 medication-free nonsmoking men, aged between 20 and 65 years (mean +/- standard error of the mean = 36.7 +/- 1.7 years), underwent an acute standardized psychosocial stress task combining public speaking and mental arithmetic in front of an audience. We measured plasma clotting factor VII activity (FVII:C), fibrinogen, and D-dimer at rest, immediately, and 20 minutes after stress.
  
  
  RESULTS
  Increased age predicted greater increases in fibrinogen (beta = 0.26, p = 0.041; DeltaR(2) = 0.05), FVII:C (beta = 0.40, p = .006; DeltaR(2) = 0.11), and D-dimer (beta = 0.51, p < .001; DeltaR(2) = 0.18) from rest to 20 minutes after stress independent of body mass index and mean arterial blood pressure. General linear models revealed significant effects of age and stress on fibrinogen, FVII:C, and D-dimer (main effects: p < .04), and greater D-dimer stress reactivity with older age (interaction age-by-stress: F(1.5/90.4) = 4.36, p = .024; f = 0.33).
  
  
  CONCLUSIONS
  Our results suggest that acute stress might increase vulnerability in the elderly for hypercoagulability and subsequent hemostasis-associated diseases like CVD.
authors.affiliation: Department of Clinical Psychology and Psychotherapy, University of Zurich, Binzmühlestrasse 14, Box 26, CH-8050 Zurich, Switzerland. p.wirtz@psychologie.unizh.ch
authors.forename: Petra H
authors.initials: PH
authors.lastname: Wirtz
authors.forename: Laura S
authors.initials: LS
authors.lastname: Redwine
authors.forename: Carmen
authors.initials: C
authors.lastname: Baertschi
authors.forename: Maria
authors.initials: M
authors.lastname: Spillmann
authors.forename: Ulrike
authors.initials: U
authors.lastname: Ehlert
authors.forename: Roland
authors.initials: R
authors.lastname: von Känel
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000941:Antigens / Q000097:blood; D001143:Arousal / Q000502:physiology; D005167:Factor VII; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011602:Psychophysiologic Disorders / Q000097:blood* / Q000523:psychology*; D012307:Risk Factors; D013315:Stress, Psychological / Q000097:blood* / Q000523:psychology; D019851:Thrombophilia / Q000097:blood* / Q000523:psychology*
chemical_list: D000941:Antigens; D005338:Fibrin Fibrinogen Degradation Products; C042580:factor VII clotting antigen; C036309:fibrin fragment D; D005167:Factor VII; D005340:Fibrinogen