title: Serial assessment of immune status by circulating CD8 effector T cell frequencies for posttransplant infectious complications.
abstract: To clarify the role of CD8+ effector T cells for infectious complications, 92 recipients were classified according to the hierarchical clustering of preoperative CD8+CD45 isoforms: Group I was naive, Group II was effector memory, and Group III was effector (E) T cell-dominant. The posttransplant infection rates progressively increased from 29% in Group I to 64.3% in Group III recipients. The posttransplant immune status was compared with the pretransplant status, based on the measure (% difference) and its graphical form (scatter plot). In Groups I and II, both approaches showed a strong upward deviation from pretransplant status upon posttransplant infection, indicating an enhanced clearance of pathogens. In Group III, in contrast, both approaches showed a clear downward deviation from preoperative status, indicating deficient cytotoxicity. The % E difference and scatter plot can be used as a useful indicator of a posttransplant infectious complication.
authors.affiliation: Department of Transplantation and Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Uemoto
authors.forename: Kazue
authors.initials: K
authors.lastname: Ozawa
authors.forename: Hiroto
authors.initials: H
authors.lastname: Egawa
authors.forename: Yasutsugu
authors.initials: Y
authors.lastname: Takada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.forename: Satoshi
authors.initials: S
authors.lastname: Teramukai
authors.forename: Mureo
authors.initials: M
authors.lastname: Kasahara
authors.forename: Kohei
authors.initials: K
authors.lastname: Ogawa
authors.forename: Masako
authors.initials: M
authors.lastname: Ono
authors.forename: Kenji
authors.initials: K
authors.lastname: Takai
authors.forename: Masanori
authors.initials: M
authors.lastname: Fukushima
authors.forename: Kayo
authors.initials: K
authors.lastname: Inaba
authors.forename: Koichi
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D007239:Infections / Q000453:epidemiology / Q000209:etiology / Q000276:immunology / Q000401:mortality; D016031:Liver Transplantation / Q000009:adverse effects* / Q000276:immunology*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology / Q000276:immunology / Q000401:mortality