Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
By linking actin dynamics to extracellular components, integrins are involved in a wide range of cellular processes that are associated with or require cytoskeletal remodelling and cell-shape changes. One such function is integrin-dependent phagocytosis, a process that several integrins are capable of mediating and that allows the binding and clearance of particles. Integrin-dependent phagocytosis is involved in a wide range of physiological processes, from the clearance of microorganisms and apoptotic-cell removal to extracellular-matrix remodelling. Integrin signalling is also exploited by microbial pathogens for entry into host cells. Far from being a particular property of specific integrins and specialised cells, integrin-dependent uptake is emerging as a general, intrinsic ability of most integrins that is associated with their capacity to signal to the actin cytoskeleton. Integrin-mediated phagocytosis can therefore be used as a robust model in which to study integrin regulation and signalling.
Dupuy
Aurélien G
AG
Centre for Molecular Microbiology and Infection and Division of Cell and Molecular Biology, Imperial College London, London, UK.
Caron
Emmanuelle
E
D000199:Actins / Q000378:metabolism*; D000818:Animals; D001422:Bacterial Adhesion / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D010587:Phagocytosis / Q000502:physiology*; D011485:Protein Binding / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D000199:Actins; D016023:Integrins