title: [Cardiovascular effects of D-ALA2, LEU5, ARG6-enkephalin (dalargin) are mediated by peripheral mu-opioid receptor activation].
abstract: It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the "steal syndrome." The positive chronotropic effect of dalargin was mediated by peripheral mu-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Lishmanov
authors.forename: E I
authors.initials: EI
authors.lastname: Barzakh
authors.forename: I V
authors.initials: IV
authors.lastname: Maksimov
authors.forename: I N
authors.initials: IN
authors.lastname: Vorozgtsova
authors.forename: I L
authors.initials: IL
authors.lastname: Bukhovets
authors.forename: S M
authors.initials: SM
authors.lastname: Minin
authors.forename: E B
authors.initials: EB
authors.lastname: Orlova
authors.forename: A G
authors.initials: AG
authors.lastname: Lavrov
authors.forename: M V
authors.initials: MV
authors.lastname: Ovchinnikov
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016308:Enkephalin, Leucine-2-Alanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000819:agonists* / Q000037:antagonists & inhibitors
chemical_list: D000889:Anti-Arrhythmia Agents; D017450:Receptors, Opioid, mu; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-