Model for hand-over-hand motion of molecular motors.
A simple flashing ratchet model in two dimensions is proposed to simulate the hand-over-hand motion of two head molecular motors such as kinesin. Extensive Langevin simulations of the model are performed. Good qualitative agreement with the expected behavior is observed. We discuss different regimes of motion and efficiency depending on model parameters.
Munárriz
J
J
Departemento de Física de la Materia Condensada, Universidad de Zaragoza, 50009 Zaragoza, Spain.
Mazo
J J
JJ
Falo
F
F
D000465:Algorithms; D001703:Biophysics / Q000379:methods*; D003198:Computer Simulation; D004058:Diffusion; D016547:Kinesins / Q000737:chemistry; D007700:Kinetics; D008954:Models, Biological; D008956:Models, Chemical; D008958:Models, Molecular; D015233:Models, Statistical; D008962:Models, Theoretical; D020409:Molecular Motor Proteins / Q000378:metabolism*; D036103:Nanotechnology / Q000379:methods; D013696:Temperature
D020409:Molecular Motor Proteins; D016547:Kinesins