[Proteolytic enzymes--a highly sensitive criterium for effectiveness and safety of treatment].
The effect of ozonated saline on proteolytic enzymes: trypsin, chymotrypsin, elastase, kallikrein, leucine aminopeptidase, inhibitors of proteolysis and lipid peroxidation has been investigated. Injection of ozonated saline led to significal response of proteolytic system. Ozonated saline with low ozone doses produced a positive effect on proteolytic system. High doses of ozone produced significal reinforcement of proteolytic system and the decrease of alpha1-antitrypsin and alpha2-macroglobulin activity in blood plasma. Therefore, analyses of proteolytic activity can be used as indicator of effectiveness and safety of ozonetherapy and others treatment programms.
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Efremenko
D000818:Animals; D002918:Chymotrypsin / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D007610:Kallikreins / Q000378:metabolism; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D010126:Ozone / Q000009:adverse effects / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D010196:Pancreatic Elastase / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism*; D051381:Rats; D014357:Trypsin / Q000378:metabolism
D010126:Ozone; D010447:Peptide Hydrolases; D007931:Leucyl Aminopeptidase; D007610:Kallikreins; D002918:Chymotrypsin; D010196:Pancreatic Elastase; D014357:Trypsin