SUMO amplifies TGF-beta signalling.
Transforming growth factor-beta (TGF-beta) stimulates phosphorylation of TGF-beta type I receptor. This receptor is now shown to be sumoylated, leading to enhanced activation and modulation of the downstream Smad signalling pathway.
Kohei
K
Miyazono
Yuto
Y
Kamiya
Keiji
K
Miyazawa
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism; D010766:Phosphorylation; D025842:SUMO-1 Protein / Q000378:metabolism*; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D025842:SUMO-1 Protein; C495501:SUMO1 protein, human; D016212:Transforming Growth Factor beta