Three types of sesquiterpenes from rhizomes of Atractylodes lancea.
Eight sesquiterpenes, including four guaiane-types containing an interesting epoxy unit (1-4), a rare tricyclic carbon skeleton-type (5) and three eudesmane-types (6-8), along with five known compounds, were isolated from rhizomes of Atractylodes lancea. The structures and relative configurations of 1-8 were determined by analysis of spectroscopic data, and the absolute configuration of 8 was assigned by application of the CD technique. Compounds 1, 2 and 4 were evaluated for their cytotoxic effects against P388 and A549 cells, but all were inactive. Possible biosynthetic pathways for sesquiterpenes (1-8) were discussed.
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, PR China.
He-Xiang
HX
Wang
Chun-Mei
CM
Liu
Quan
Q
Liu
Kun
K
Gao
D031174:Atractylodes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D027343:Rhizome / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry*
D012717:Sesquiterpenes