Activation of functional arylzincs prepared from aryl iodides and highly enantioselective addition to aldehydes.
An easily available chiral ligand ( S)- 1 is found to activate the nucleophilic reaction of the arylzincs prepared in situ from the reaction of aryl iodides with Et(2)Zn. Both high yields and high enantioselectivity (up to >99% ee) for the reaction of these arylzincs with a variety of aldehydes are obtained. The mild reaction conditions and the good functional group tolerance make this catalytic asymmetric process synthetically useful.
DeBerardinis
Albert M
AM
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319, USA.
Turlington
Mark
M
Pu
Lin
L