Asymptomatic bacteriuria in patients with diabetes mellitus in Ile-Ife, South-West, Nigeria.
OBJECTIVE
To investigate the prevalence and associates of asymptomatic bacteriuria (ASB) in a sample of Nigerian diabetic patients.


METHODS
Cross-sectional descriptive and analytic study.


METHODS
The Wesley Guild Hospital and Ife State Hospital, both units of Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.


METHODS
One hundred and thirty five diabetic patients and 57 non-diabetic patients as controls.


METHODS
Demographic parameters of participants were recorded. Significant bacteriuria was determined for each of the mid-stream urine specimen obtained from all the subjects. Organisms isolated were identified and evaluated for antibiotic susceptibility patterns.


RESULTS
There was a significant difference in the prevalence of ASB in the two groups. Prevalence of ASB was 16% and 3.5% in the diabetic patients and control respectively (p=0.03). Demographic parameters except age were not related to the presence of ASB. ASB was found in 54.4% of diabetic patients with poor glycaemia control compared with 2.9% in diabetics with good glycaemia control (p = 0.006). Organisms associated with ASB were Staphylococcus aureus, Klebsiella sp, Escherichia coli and Enterococcus faecalis, however the most predominant was Staphylococcus aureus. These organisms were largely resistant to the common antibiotics tested such as cotrimoxazole and gentamicin but susceptible to nitrofurantoin.


CONCLUSIONS
The prevalence of ASB is high in diabetic patients and poor glucose control can be considered a predisposing factor.
Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
W B
WB
Odetoyin
A O
AO
Aboderin
R T
RT
Ikem
B A
BA
Kolawole
A O
AO
Oyelese
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001437:Bacteriuria / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003710:Demography; D048909:Diabetes Complications; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors
D000900:Anti-Bacterial Agents