Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance.
Antibodies have proven to be effective agents in cancer imaging and therapy. One of the major challenges still facing the field is the heterogeneous distribution of these agents in tumors when administered systemically. Large regions of untargeted cells can therefore escape therapy and potentially select for more resistant cells. We present here a summary of theoretical and experimental approaches to analyze and improve antibody penetration in tumor tissue.
Thurber
Greg M
GM
Department Chemical Engineering, Massachusetts Institute of Technology, USA.
Schmidt
Michael M
MM
Wittrup
K Dane
KD
D000818:Animals; D000906:Antibodies / Q000378:metabolism* / Q000627:therapeutic use; D000915:Antibody Affinity; D000941:Antigens / Q000502:physiology*; D001692:Biological Transport; D002199:Capillary Permeability; D004058:Diffusion; D004705:Endocytosis; D006801:Humans; D008657:Metabolic Clearance Rate; D008962:Models, Theoretical; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D010539:Permeability
D000906:Antibodies; D000941:Antigens