Hippocampal response to visual objects is related to visual memory functioning.
The medial temporal lobe participates not only in episodic memory, but also in visual object processing. Here we asked whether these processes are linked within the human hippocampus. To this end, we recorded field potentials directly from the hippocampus proper during a visual object decision task in temporal lobe epilepsy patients with either normal or below normal visual memory performance. Only in patients with normal visual memory, did the hippocampus proper differentiate reliably between real and nonsense objects, whereas neural responses to both kinds of objects were virtually the same in patients whose visual memory performance was reduced. These findings suggest that neural responses to visual objects within the hippocampus proper are directly linked to visual memory performance.
Department of Epileptology, Bonn University Medical Center, Bonn, Germany. manila.vannucci@psico.unifi.it
Manila
M
Vannucci
Nico
N
Pezer
Christoph
C
Helmstaedter
Karl
K
Schaller
Maria Pia
MP
Viggiano
Christian E
CE
Elger
Thomas
T
Grunwald
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000473:pathology* / Q000503:physiopathology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods