[Micronuclei in mucose cells and colonization of human stomach epithelium with coccoid forms of Helicobacter pylori].
International Agency for Research on Cancer recognized as sufficient the evidence of Helicobacter pylori (HP) infection carcinogenicity and placed it into the 1 st group of carcinogens. Micronucleus level in gastric epithelial cells of antral stomach region of patients with chronic non-atrophy gastritis (n = 62) was studied. 40 patients of 62 had HP-associated gastritis. The HP-bacterium exists in a spiral and coccoid form. Both morphological forms were examined using immunocytochemistry. Significantly increased micronucleus number was observed in the cells of HP-infected patients compared with non-infected person (P < 0.05). The frequency of stomach epithelium cells with micronuclei was enhanced considerably in the patients infected with the coccoid HP form. Therefore the patients with HP-associated chronic gastritis caused by the coccoid form with high degree of colonization must be considered as a group of enhanced risk of gastric carcinogenesis.
Kitaeva
L V
LV
Mikhaĭlova
I A
IA
Semov
D
D
Proshin
S N
SN
Kravtsov
V Iu
VIu
D000328:Adult; D001706:Biopsy; D002467:Cell Nucleus / Q000473:pathology*; D015169:Colony Count, Microbial; D005753:Gastric Mucosa / Q000382:microbiology* / Q000473:pathology*; D005756:Gastritis / Q000382:microbiology* / Q000473:pathology*; D016481:Helicobacter Infections / Q000382:microbiology* / Q000473:pathology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007620:Karyometry; D048629:Micronuclei, Chromosome-Defective; D015162:Micronucleus Tests; D008875:Middle Aged; D011706:Pyloric Antrum / Q000382:microbiology* / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology