Tubulointerstitial nephritis and uveitis syndrome in a mother and her son.
A mother and her son, both with tubulointerstitial nephritis and uveitis syndrome (TINU) are reported. The nephritis presented itself at 13 years in the mother and at 10 years in her son. Glomerular filtration (GFR) decreased in both, and renal biopsies confirmed the diagnosis. Nephritis preceded the onset of uveitis in both. Clinical course and renal function improved quickly on oral steroids in the boy. The mother's hyperazotemia decreased spontaneously (without steroids), but not to normal range, and remained stable for 35 years of follow-up. Local steroids due to recurrences of uveitis were repeatedly needed in both. We believe this is the first report on familial occurrence of inherited TINU syndrome in two generations.
Dusek
Jiri
J
Department of Pediatrics, University Hospital Motol, Charles University, 2nd Medical School, Prague, Czech Republic. j.dusek@lfmotol.cuni.cz
Urbanova
Ivana
I
Stejskal
Josef
J
Seeman
Tomas
T
Vondrak
Karel
K
Janda
Jan
J
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D005192:Family Health; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D009395:Nephritis, Interstitial / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D014605:Uveitis / Q000235:genetics* / Q000628:therapy