Pulmonary extramedullary hematopoiesis.
Extramedullary hematopoiesis (EMH) is the formation and development of blood cells outside of the bone marrow. Of particular interest to chest physicians and radiologists is the occurrence of EMH in the lungs and pleura. There have been several reports of patients presenting with pulmonary EMH published in the literature and the majority are due to a secondary process, such as myeloproliferative disorders, hemolytic anemias, hereditary spherocytosis, and Gaucher disease. We present a case report of pulmonary EMH and a review of the literature concentrating on the etiology, clinical presentation, pathophysiology, diagnosis, and therapy for this uncommon disorder.
Department of Internal Medicine, Section on Pulmonary and Critical Care, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. MBowling@wfumbc.edu
Mark Rollin
MR
Bowling
Carlton Gregory
CG
Cauthen
Christopher David
CD
Perry
Nilesh Prahlad
NP
Patel
Simon
S
Bergman
Kerry Michael
KM
Link
Aneysa Christine
AC
Sane
John Frank
JF
Conforti
D000743:Anemia, Hemolytic / Q000209:etiology; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001168:Arthritis / Q000150:complications; D001379:Azathioprine / Q000627:therapeutic use; D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D015352:Dry Eye Syndromes / Q000209:etiology; D004417:Dyspnea / Q000209:etiology; D005260:Female; D006411:Hematopoiesis, Extramedullary / Q000187:drug effects*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis* / Q000188:drug therapy; D008875:Middle Aged; D010996:Pleural Effusion / Q000209:etiology; D011658:Pulmonary Fibrosis / Q000150:complications; D011928:Raynaud Disease / Q000209:etiology; D012859:Sjogren's Syndrome / Q000150:complications / Q000188:drug therapy; D020181:Sleep Apnea, Obstructive / Q000150:complications; D014057:Tomography, X-Ray Computed; D014657:Vasculitis / Q000150:complications
D018501:Antirheumatic Agents; D001379:Azathioprine