Production of teicoplanin from Actinoplanes teichomyceticus ID9303 by adding proline.
We evaluated the influence of amino acids in improving teicoplanin productivity. Arginine, lysine, and proline were selected for better productivity among 20 amino acids in Erlenmeyer flasks. Proline was finally chosen as the additive for maximum teicoplanin productivity in a 5-liter fermenter. We obtained the highest teicoplanin productivity, 3.12 g/l, on the eighth d in a 75-liter pilot fermenter.
Song
Jung-Min
JM
Research Laboratories, Ildong Pharmaceutical, Yongin 449-910, Korea.
Park
Joon-Tae
JT
Lee
Hong-Sub
HS
Kang
Jae-Hoon
JH
Kang
Dae-Jung
DJ
D000192:Actinomycetales / Q000187:drug effects / Q000378:metabolism*; D011392:Proline / Q000378:metabolism* / Q000494:pharmacology; D017334:Teicoplanin / Q000096:biosynthesis*
D017334:Teicoplanin; D011392:Proline