Hydrolytic degradation characteristics of irradiated multi-layered PLGA films.
Poly(lactide-co-glycolide) (PLGA) has been extensively investigated for controlled drug release. Because they undergo bulk degradation, they do not allow for a good controlled-release of drugs. The objective of this study is therefore to understand if a multi-layer-cum-irradiation technique would elicit surface erosion from PLGA polymers. A linear loss of mass and film thinning from PLGA films were observed. Also, the erosion of the top layer, of this multi-layered structure, accelerates degradation of the underlying layers. It is this effect that results in the observed pseudo-surface erosion for irradiated multi-layered PLGA.
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore. joachimloo@ntu.edu.sg
Say Chye
SC
Joachim Loo
Wei Li
WL
Jason Tan
Shu Min
SM
Khoa
Ngeow Khing
NK
Chia
Subbu
S
Venkatraman
Freddy
F
Boey
D002850:Chromatography, Gel; D005079:Excipients / Q000737:chemistry* / Q000528:radiation effects; D006868:Hydrolysis; D019344:Lactic Acid / Q000737:chemistry* / Q000528:radiation effects; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000528:radiation effects; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013499:Surface Properties; D014867:Water / Q000737:chemistry
D005079:Excipients; D008567:Membranes, Artificial; D014867:Water; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid