Towards noninvasive molecular fluorescence imaging of the human brain.
Fluorescence molecular brain imaging is a new modality allowing the detection of specific contrast agents down to very low concentration ranges (picomolar) in disease models. Here we demonstrate a first noninvasive application of fluorescence imaging in the human brain, where concentrations down to about 100 nM of a nonspecific dye were detected. We argue that due to its high sensitivity, optical molecular imaging of the brain is feasible, which - together with its bedside applicability - makes it a promising technique for use in patients.
Steinbrink
J
J
Clinic of Neurology, Charité - Universitatsmedizin Berlin, Berlin, Germany. jens.steinbrink@charite.de
Liebert
A
A
Wabnitz
H
H
Macdonald
R
R
Obrig
H
H
Wunder
A
A
Bourayou
R
R
Betz
T
T
Klohs
J
J
Lindauer
U
U
Dirnagl
U
U
Villringer
A
A
D000818:Animals; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D005453:Fluorescence; D006801:Humans; D051379:Mice; D008967:Molecular Biology / Q000379:methods; D012680:Sensitivity and Specificity; D019265:Spectroscopy, Near-Infrared / Q000379:methods*