Excessive lateral dental arch expansion in experimentally developed acromegaly-like rats.
OBJECTIVE
To investigate morphological changes in the dental arches of acromegaly-like rats recently developed by means of exogenous IGF-I administration.


METHODS
Human recombinant IGF-I (640microg/day) was continuously administered subcutaneously for 4 weeks by osmotic mini-pumps to 10-week-old male rats (n=6). Control animals were injected with saline alone (n=6). After administration, all the rats were housed for 4 more weeks. Arch width (W), length (L) and angle (theta) in the mandible and maxilla were measured once a week during and after IGF-I administration.


RESULTS
The concentration of circulating IGF-I, and W and theta in the mandible were significantly increased as compared with the control rats. Although the mandibular dental arch stopped expanding once administration ended, it did not return to the control size.


CONCLUSIONS
In our acromegaly-like rat model, mandibular dental arch growth is greater in the lateral than antero-posterior direction during and after IGF-I administration.
Iikubo
Masahiro
M
Department of Oral Diagnosis, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. machapy@mail.tains.tohoku.ac.jp
Kobayashi
Akane
A
Kojima
Ikuho
I
Ikeda
Hidetoshi
H
Sakamoto
Maya
M
Sasano
Takashi
T
D000172:Acromegaly / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology*; D000818:Animals; D001699:Biometry / Q000379:methods; D001835:Body Weight / Q000187:drug effects; D003724:Dental Arch / Q000254:growth & development* / Q000473:pathology; D004195:Disease Models, Animal; D007334:Insulin-Like Growth Factor I / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D008334:Mandible / Q000254:growth & development / Q000473:pathology; D008437:Maxilla / Q000254:growth & development / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology
D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I