In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy.
Polymyxin B, minocycline, and tigecycline were the most potent of 10 antibiotics against 170 isolates of multidrug-resistant Acinetobacter baumannii. In time-kill studies, the exposure of a highly tigecycline-resistant isolate to tigecycline resulted in enhanced susceptibility to amikacin and synergistic bactericidal activities of the two drugs.
Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68178, USA.
Ellen S
ES
Moland
David W
DW
Craft
Seong-geun
SG
Hong
Soo-young
SY
Kim
Lucas
L
Hachmeister
Shimon D
SD
Sayed
Kenneth S
KS
Thomson
D040981:Acinetobacter baumannii / Q000187:drug effects*; D000583:Amikacin / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D000078304:Tigecycline
D000078304:Tigecycline; D000583:Amikacin; D008911:Minocycline