[Development of highly selective and sensitive fluorescent and chemiluminescent reagents].
Fluorescence (FL), chemiluminescence (CL) and bioluminescence (BL) have been extensively focused on luminescence assays. Various FL and CL compounds have been synthesized and evaluated their FL and CL properties. This review describes development of highly selective and sensitive FL and CL reagents by derivatizing luminol, indole and polyphenol. Luminol derivatives were used for measuring enzyme activities and ultraviolet ray power. Indole derivatives with large stokes shift and long-lasting CL properties were developed. Compound which had enhancement effect on polyphenol CL was found. Highly sensitive CL polyphenol dendrimers were synthesized.
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan. nakazono@phar.kyushu-u.ac.jp
Manabu
M
Nakazono
D050091:Dendrimers; D005419:Flavonoids; D007202:Indicators and Reagents / Q000138:chemical synthesis*; D007211:Indoles; D049449:Luminescence; D008163:Luminescent Measurements; D008165:Luminol; D010636:Phenols; D059808:Polyphenols; D013056:Spectrophotometry, Ultraviolet
D050091:Dendrimers; D005419:Flavonoids; D007202:Indicators and Reagents; D007211:Indoles; D010636:Phenols; D059808:Polyphenols; D008165:Luminol; C030374:indole