Characterization of extended-spectrum beta-lactamases in Salmonella spp. at a tertiary hospital in Durban, South Africa.
Extended-spectrum beta-lactamases (ESBLs) were characterized in 41 Salmonella spp. isolates from patients admitted to a pediatric ward of a tertiary hospital in Durban, South Africa. The most common (17/ 41) serotype was Salmonella enterica serotype Typhimurium, followed by S. enterica serotype Isangi (16/41), S. enterica serotype Saint-paul (2/41), S. enterica serotype Kissi (2/41), S. enterica serotype Kivu (2/41), and S. enterica serotype Reading (1/41). All isolates were resistant to ampicillin, amoxicillin-clavulanate, piperacillin, ceftazidime, and aztreonam but susceptible to meropenem. SHV-12 found in 39% of the isolates was the most common ESBL. TEM-63 was produced in 29% and TEM-116 in 10% of the isolates, and TEM-131 was found in 1 isolate. Other ESBLs that were identified included SHV-2 (n = 2), CTX-M-3 (n = 1), CTX-M-15 (n = 2), and CTX-M-37 (n = 5). In addition, CMY-2 (n = 3) and the OXA-1(n = 1) beta-lactamase were also detected. The diversity of ESBLs suggests that its incidence in Salmonellae needs to be monitored.
School of Pharmacy and Pharmacology, University of Kwazulu Natal, Durban, Kwazulu Natal 4000, South Africa. govindenu@ukzn.ac.za
Govinden
G
Usha
Mocktar
M
Chunderika
Moodley
M
Prashini
Sturm Adriaan
SA
Willem
Essack Sabiha
ES
Yusuf
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003967:Diarrhea / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D006761:Hospitals; D006801:Humans; D007231:Infant, Newborn; D007525:Isoelectric Focusing; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D012475:Salmonella / Q000145:classification / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D012480:Salmonella Infections / Q000453:epidemiology / Q000382:microbiology; D017422:Sequence Analysis, DNA; D013019:South Africa / Q000453:epidemiology; D001618:beta-Lactamases / Q000145:classification* / Q000235:genetics
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases