High-density lipoprotein and atheroma monitoring.
OBJECTIVE
To highlight the use of arterial wall imaging to evaluate the impact of therapies that promote high-density lipoproteins.


RESULTS
High-density lipoproteins possess a number of biological properties, which have a direct impact on the extent and composition of atherosclerosis. Arterial wall imaging has been employed to demonstrate the beneficial influence on atherosclerosis of a number of therapeutic agents that modify high-density lipoprotein.


CONCLUSIONS
Atheroma imaging has become an integral component of the clinical development of novel therapeutic agents designed to promote the atheroprotective activity of high-density lipoprotein.
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA. nichols1@ccf.org
Stephen J
SJ
Nicholls
E Murat
EM
Tuzcu
D050197:Atherosclerosis / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D053480:Cholesterol Ester Transfer Proteins / Q000037:antagonists & inhibitors; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism / Q000627:therapeutic use*; D016896:Treatment Outcome
D053480:Cholesterol Ester Transfer Proteins; D008075:Lipoproteins, HDL