The association between high-dose diuretics and clinical stability in ambulatory chronic heart failure patients.
OBJECTIVE
In chronic heart failure (HF), diuretic doses increase as the disease progresses, often after hospitalization for instability, and have been associated with worsening renal function and increased mortality.


RESULTS
A prospective observational analysis of 183 patients in an advanced HF clinic stratified at baseline by diuretic dose (low dose < or = 80 mg, high dose > 80 mg furosemide equivalent) was performed. All patients were followed for 1 year, and the primary outcome was a combined HF event of admission for HF, cardiac transplant, mechanical cardiac support, or death. Compared with patients taking low-dose diuretics (n = 113), patients taking high-dose diuretics (n = 70) had more markers of increased cardiovascular risk and were more likely to have a history of recent instability (33% vs 4.4% in low dose, P < .001). High doses of diuretics were a strong univariate predictor of subsequent HF events (hazard ratio 3.83, 95% confidence interval 1.82-8.54); however, after adjustment for clinical stability, diuretic dose no longer remained significant (hazard ratio 1.53, 95% confidence interval 0.58-4.03).


CONCLUSIONS
High-dose diuretics may be more of a marker than a cause of instability. A history of HF stability during the past 6 months is associated with an 80% lower risk of an HF event during the next year, independently of baseline diuretic dose.
Mielniczuk
Lisa M
LM
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Tsang
Sui W
SW
Desai
Akshay S
AS
Nohria
Anju
A
Lewis
Eldrin F
EF
Fang
James C
JC
Baughman
Kenneth L
KL
Stevenson
Lynne Warner
LW
Givertz
Michael M
MM
D000553:Ambulatory Care; D000554:Ambulatory Care Facilities; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D002034:Bumetanide / Q000008:administration & dosage; D015897:Comorbidity; D004232:Diuretics / Q000008:administration & dosage*; D005260:Female; D005665:Furosemide / Q000008:administration & dosage; D006305:Health Status Indicators; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013449:Sulfonamides / Q000008:administration & dosage; D000077786:Torsemide; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D004232:Diuretics; D013449:Sulfonamides; D002034:Bumetanide; D005665:Furosemide; D000077786:Torsemide