Nanorheology of viscoelastic shells: applications to viral capsids.
We study the microrheology of nanoparticle shells [A. D. Dinsmore, Science 298, 1006 (2002)] and viral capsids [I. L. Ivanovska, Proc. Natl. Acad. Sci. U.S.A. 101, 7600 (2004)] by computing the mechanical response function and thermal fluctuation spectrum of a viscoelastic spherical shell that is permeable to the surrounding solvent. We determine analytically the damped dynamics of bend and compression modes of the shell coupled to the solvent both inside and outside the sphere in the zero Reynolds number limit. We identify fundamental length and time scales in the system, and compute the thermal correlation function of displacements of antipodal points on the sphere and the mechanical response to pinching forces applied at these points. We describe how such a frequency-dependent antipodal correlation and/or response function, which should be measurable in new AFM-based microrheology experiments, can probe the viscoelasticity of these synthetic and biological shells constructed of nanoparticles.
Kuriabova
Tatiana
T
Department of Physics & Astronomy, University of California, Los Angeles, California 90095, USA.
Levine
Alex J
AJ
D001703:Biophysics / Q000379:methods*; D002213:Capsid / Q000737:chemistry*; D003198:Computer Simulation; D004548:Elasticity; D007700:Kinetics; D018625:Microscopy, Atomic Force; D008954:Models, Biological; D015233:Models, Statistical; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011312:Pressure; D012212:Rheology / Q000379:methods*; D012997:Solvents / Q000737:chemistry; D014780:Viruses / Q000378:metabolism*; D014783:Viscosity
D012997:Solvents