Regio- and stereoselective hydroamidation of 1-alkynylphosphine sulfides catalyzed by cesium base.
Regio- and stereoselective hydroamidation of 1-alkynylphosphine sulfides proceeds in the presence of cesium carbonate to provide (E)-2-amino-1-thiophosphinyl-1-alkenes. Asymmetric hydrogenation of the adducts catalyzed by an iridium complex followed by desulfidation yields 2-amino-1-phosphinoalkanes, which offers a new approach to chiral N,P-ligands that will potentially serve as ligands in asymmetric reactions.
Kondoh
Azusa
A
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Yorimitsu
Hideki
H
Oshima
Koichiro
K