Efficient and versatile synthesis of new porphyrins bearing an N3O moiety: ligands for mimicking cytochrome c oxidase.
Two new generations of ligands for cytochrome c oxidase mimicking have been designed and synthesized via an efficient, convergent, and versatile synthesis. These porphyrins are functionalized with both an internal nitrogen base on one side and a triaza (N3) or a triaza-phenol (N3O) moiety on the other side, attached to the macrocycle by various spacers. Unlike tailed porphyrins, the triaza motif as well as the nitrogen base are linked by two points.
Université de Rennes1, Sciences Chimiques de Rennes, Ingénierie Chimique et Molécules du Vivant, UMR CNRS 6226, 35042 Rennes Cedex, France.
Christian
C
Ruzié
Pascale
P
Even-Hernandez
Bernard
B
Boitrel
D001372:Aza Compounds / Q000737:chemistry*; D001665:Binding Sites; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D003576:Electron Transport Complex IV / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry
D001372:Aza Compounds; D008024:Ligands; D010636:Phenols; D011166:Porphyrins; D003576:Electron Transport Complex IV