Complete and unambiguous assignments of 1H and 13C chemical shifts of new arylamino derivatives of ortho-naphthofuranquinones.
Six new nor-beta-lapachones have been synthesized from reaction of 3-bromo-nor-beta-lapachone with arylamines. These derivatives have potent anticancer properties against several cell lines. Here, we report complete unambiguous assignments of (1)H and (13)C chemical shifts of the new compounds. The assignments were made using a combination of one- and two-dimensional NMR techniques ((1)H, (13)C, (1)H-(1)H COSY, (1)H-(13)C HSQC, and (1)H-(13)C HMBC).
Universidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, Campus do Valonguinho, 24020-141, Niterói, RJ, Brazil.
Eufrânio N
EN
da Silva Júnior
Maria Cecília B V
MC
de Souza
Antônio V
AV
Pinto
Maria do Carmo F R
Mdo C
Pinto
Christiane M
CM
Nogueira
Vitor F
VF
Ferreira
Rodrigo B V
RB
Azeredo
D000588:Amines / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry; D002247:Carbon Isotopes; D005663:Furans / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009281:Naphthalenes / Q000737:chemistry; D011809:Quinones / Q000737:chemistry*
D000588:Amines; D000970:Antineoplastic Agents; D002247:Carbon Isotopes; D005663:Furans; D009281:Naphthalenes; D011809:Quinones