Intra-abdominal leiomyosarcoma in a ferret (Mustela putorius Furo): histopathological and immunohistochemical characterization.
A 5 years old female ferret with an abdominal palpable mass confirmed at echo-graphic examination died during an explorative laparotomy. A single lymph-node-like nodule was found adjacent to the intestinal loops. The round mass well circumscribed, solid and white, histologically, at low magnification, appeared encapsulated and built up by a population of atypical spindle cells arranged in interwoven fascicles. The cells had high anisocytosis degree, moderate mitotic activity and prominent nucleoli. A central area of necrosis was present. To characterise the tumour immunohistochemically cytokeratin, vimentin, S-100, melan-A, vWF, desmin, actin and alpha-actin were applied. Neoplastic cells resulted positive to vimentin, actin and alpha-actin. Based on the histological and immunohistological pattern a diagnosis of leiomyosarcoma was made.
Pezzolato
Marzia
M
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Area Neuroscienze e Genetica, Laboratorio di Immunoistopatologia, Torino, Italy. istopatologia.ufficio@izsto.it
Varello
Katia
K
Mascarino
Daniela
D
Bozzato
Elisa
E
Vascellari
Marta
M
Bozzetta
Elena
E
D000008:Abdominal Neoplasms / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D005260:Female; D005289:Ferrets; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000473:pathology / Q000662:veterinary*