Miniaturized membrane sensors for the determination of rivastigmine hydrogen tartrate.
Novel miniaturized polyvinyl chloride (PVC) membrane sensors in all-solid state graphite and platinum wire supports were developed, electrochemically evaluated and used for the assay of rivastigmine hydrogen tartrate drug (RIV). The RIV sensors are based on the formation of an ion-association complex between the drug cation and tetrakis(4-chlorophenyl)borate (TpClPB) anionic exchanger as electroactive material dispersed in a PVC matrix. Linear responses of 10(-2) - 10(-5) M and 10(-2) - 10(-4) M with cationic slopes of 56.4 mV and 53.6 mV over the pH range 4 - 7 were obtained by using the RIV-coated graphite (sensor 1) and platinum wire (sensor 2) membrane sensors, respectively. The proposed method displays useful analytical characteristics for the determination of RIV in Exelon capsules with average recoveries of 100.01+/-0.835, 100.09+/-0.896, and in plasma with average recoveries of 99.47+/-0.97, 99.58+/-0.82, and in rat brain homogenate with average recoveries of 98.16+/-1.62, 99.02+/-1.57, for sensors 1 and 2, respectively. The methods were also used to determine the intact drug in the presence of its degradation product and thus could be used as stability indicating methods. The results obtained by the proposed procedures were statistically analyzed and compared with those obtained by using a reported method. No significant difference for both accuracy and precision was observed.
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Amira Mabrouk
AM
El-Kosasy
Maissa Yacoub
MY
Salem
Mohamed Galal
MG
El-Bardicy
Mohamed Khaled Abd
MK
El-Rahman
D000818:Animals; D001923:Brain Chemistry; D002138:Calibration; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D003116:Color; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D008567:Membranes, Artificial; D008839:Microelectrodes; D009391:Nephelometry and Turbidimetry; D018697:Nootropic Agents / Q000032:analysis*; D048448:Phenylcarbamates / Q000032:analysis*; D011199:Potentiometry; D051381:Rats; D000068836:Rivastigmine; D013696:Temperature; D014783:Viscosity
D002214:Capsules; D007202:Indicators and Reagents; D008567:Membranes, Artificial; D018697:Nootropic Agents; D048448:Phenylcarbamates; D000068836:Rivastigmine