Acute encephalopathy with human parvovirus B19 infection in hereditary spherocytosis.
A 9-year-old girl with hereditary spherocytosis developed aplastic crisis and encephalopathy associated with human parvovirus B19 (PVB19) infection. During the clinical course, we followed PVB19 DNA in her plasma and cerebrospinal fluid by real-time polymerase chain reaction and found that her symptoms of encephalopathy had occurred at the peak viral load. PVB19-associated encephalopathy might occur as a result of direct invasion by PVB19.
Oshima
Koichi
K
Division of Hematology/Oncology, Saitama Children's Medical Center, Saimata, Japan. oshima-k@umin.ac.jp
Kikuchi
Akira
A
Mochizuki
Shinji
S
Arai
Takashi
T
Oishi
Tsutomu
T
Hanada
Ryoji
R
D002648:Child; D004279:DNA, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D018792:Encephalitis, Viral / Q000821:virology*; D005260:Female; D006801:Humans; D010322:Parvoviridae Infections / Q000150:complications* / Q000821:virology*; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction / Q000379:methods; D013103:Spherocytosis, Hereditary / Q000150:complications*; D019562:Viral Load
D004279:DNA, Viral