Relation of glutathione S-transferase T1, M1 and P1 genotypes and breast cancer risk.
The aim of this study was to investigate associations between genetic variability in specific Glutathione S-transferases (GST) genes (GSTM1, GSTT1 and GSTP1) and susceptibility to breast cancer. Genotypes of blood specimen DNA were determined for 65 women with incident cases of breast cancer and 108 control subjects. Associations between specific genotypes and the development of breast cancer were examined by the use of logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Neither GSTT1 nor GSTM1 homozygous null genotype was associated with a significant increased risk of developing breast cancer. The presence of valine alleles compared to isoleucine alleles in codon 105 in GSTP1 did not increase the risk of breast cancer development. The risk of breast cancer associated with a combined GSTT1 and GSTM1 null genotype was 3.37 (95% CI = 0.76-2.95, p = 0.115). The only significant association between increased risk of breast cancer development and GSTs polymorphisms was found when GSTT1 null, GSTM1 null and the presence of valine in GSTP1 in codon 105 were combined (p < 0.048, OR = 3.75, 95% CI = 1.01-13.90). Our findings suggest that combined genetic variability in members of the GST gene family may be associated with an increased susceptibility to breast cancer.
Department of Biochemistry, Selçuk Universitesi Meram Medical School, Turkey.
Ali
A
Unlü
Nurcan Aras
NA
Ates
Lülüfer
L
Tamer
Cengiz
C
Ates
D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics; D001943:Breast Neoplasms / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000172:deficiency / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000172:deficiency / Q000235:genetics; D007532:Isoleucine / Q000235:genetics; D008875:Middle Aged; D005810:Multigene Family; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D014633:Valine / Q000235:genetics
D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D007527:Isoenzymes; D007532:Isoleucine; D014633:Valine; C413545:glutathione S-transferase T1