Medial necrosis due to sirolimus-eluting stent implantation in human coronary artery.
We report an autopsy case showing medial necrosis at the segment of sirolimus-eluting stent implantation. These findings indicate that cytotoxic effects of sirolimus can induce late-acquired incomplete stent apposition and/or aneurysmal changes after stenting in human coronary arteries.
Department of Cardiology, Kurashiki Central Hospital, Miwa, Kurashiki 710-8602, Japan. takenaka@m.kufm.kagoshima-u.ac.jp <takenaka@m.kufm.kagoshima-u.ac.jp>
Katsumi
K
Inoue
Kazuaki
K
Mitsudo
Masakiyo
M
Nobuyoshi
D000368:Aged; D001344:Autopsy; D003327:Coronary Disease / Q000209:etiology*; D023903:Coronary Restenosis / Q000517:prevention & control; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009336:Necrosis / Q000139:chemically induced; D020123:Sirolimus / Q000008:administration & dosage* / Q000009:adverse effects*; D017539:Tunica Intima / Q000473:pathology
D020123:Sirolimus