Curcumin ameliorates aflatoxin-induced lipid peroxidation in liver, kidney and testis of mice--an in vitro study.
The present investigation was an attempt to evaluate the possible ameliorative effect of curcumin on aflatoxin-induced lipid peroxidation in liver, kidney and testis of mice in vitro. Tissues were collected from healthy Swiss strain male albino mice Mus musculus weighing 30-35 g. The homogenates were treated with aflatoxin (2-10 mg/mL) with and without curcumin (25-200 mg/mL). The results revealed that addition of aflatoxin (2-10 mg/mL) to homogenates caused significant increase in lipid-peroxidation which was maximal at 6 mg/mL aflatoxin concentration. However, concurrent addition of aflatoxin (6 mg/mL) and curcumin ((25-200 mg/mL) caused concentration-dependent amelioration in aflatoxin-induced lipid peroxidation.
Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad-380 009, India.
Neeta
N
Mathuria
Ramtej J
RJ
Verma
D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003474:Curcumin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D013737:Testis / Q000187:drug effects* / Q000378:metabolism
D000348:Aflatoxins; D000975:Antioxidants; D003474:Curcumin