Shooting the messenger: CULLIN' insulin signaling with Fbw8.
When phosphorylated by mTORC1/S6K, the insulin receptor substrate (IRS-1) is targeted for ubiquitination and proteasomal degradation. In a recent issue of Molecular Cell, Xu et al. reveal that the E3 ubiquitin-ligase CUL7/Fbw8 targets IRS-1 for degradation, thereby implicating this enzyme in the regulation of insulin signaling.
Cancer Research UK Department of Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, United Kingdom.
Virginie
V
Mieulet
Richard F
RF
Lamb
D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D044842:Cullin Proteins / Q000235:genetics / Q000378:metabolism*; D044783:F-Box Proteins / Q000378:metabolism*; D055504:Insulin Receptor Substrate Proteins; D051379:Mice; D008954:Models, Biological; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010766:Phosphorylation; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D017434:Protein Structure, Tertiary; D040901:Proteomics; D014157:Transcription Factors / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D054875:Ubiquitination
D048868:Adaptor Proteins, Signal Transducing; C519509:Crtc1 protein, mouse; C494817:Cul7 protein, mouse; D044842:Cullin Proteins; D044783:F-Box Proteins; C513332:Fbxw8 protein, mouse; D055504:Insulin Receptor Substrate Proteins; C526295:Irs1 protein, mouse; D014157:Transcription Factors; D044767:Ubiquitin-Protein Ligases; D019869:Phosphatidylinositol 3-Kinases; D046988:Proteasome Endopeptidase Complex