Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities.
Bioassay-guided purification from the seeds of Peganum harmala led to the isolation of harmine (1), harmaline (2), vasicinone (3), and deoxyvasicinone (4). Harmine (1) and harmaline (2) showed a moderate in vitro antiplasmodial activity against Plasmodium falciparum. Quinazoline alkaloid, vasicinone (3), showed a vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.
Astulla
Adil
A
Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo, 142-8501, Japan.
Zaima
Kazumasa
K
Matsuno
Yosuke
Y
Hirasawa
Yusuke
Y
Ekasari
Wiwied
W
Widyawaruyanti
Aty
A
Zaini
Noor Cholies
NC
Morita
Hiroshi
H
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology; D006246:Harmaline / Q000302:isolation & purification / Q000494:pharmacology; D006247:Harmine / Q000302:isolation & purification / Q000494:pharmacology; D032443:Peganum / Q000737:chemistry*; D010656:Phenylephrine; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects; D011799:Quinazolines / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D012639:Seeds; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000302:isolation & purification / Q000494:pharmacology
D000470:Alkaloids; D000962:Antimalarials; D010936:Plant Extracts; D011799:Quinazolines; D014665:Vasodilator Agents; D010656:Phenylephrine; D006247:Harmine; C025696:2,3-trimethylene-4-quinazolone; D006246:Harmaline; C052548:vasicinone