PIE: an online prediction system for protein-protein interactions from text.
Protein-protein interaction (PPI) extraction has been an important research topic in bio-text mining area, since the PPI information is critical for understanding biological processes. However, there are very few open systems available on the Web and most of the systems focus on keyword searching based on predefined PPIs. PIE (Protein Interaction information Extraction system) is a configurable Web service to extract PPIs from literature, including user-provided papers as well as PubMed articles. After providing abstracts or papers, the prediction results are displayed in an easily readable form with essential, yet compact features. The PIE interface supports more features such as PDF file extraction, PubMed search tool and network communication, which are useful for biologists and bio-system developers. The PIE system utilizes natural language processing techniques and machine learning methodologies to predict PPI sentences, which results in high precision performance for Web users. PIE is freely available at http://bi.snu.ac.kr/pie/.
Biointelligence Laboratory, School of Computer Science and Engineering, Seoul National University, Seoul 151-744, Korea.
Sun
S
Kim
Soo-Yong
SY
Shin
In-Hee
IH
Lee
Soo-Jin
SJ
Kim
Ram
R
Sriram
Byoung-Tak
BT
Zhang
D020407:Internet; D025941:Protein Interaction Mapping; D039781:PubMed; D012984:Software; D014584:User-Computer Interface