Removal of J-coupling peak distortion in PGSE experiments.
Peak distortion caused by homonuclear J-coupling is a major problem that limits the utility of the pulsed-field gradient spin-echo (PGSE) method for studying translational diffusion. This unwanted effect can be removed by incorporation of anti-phase magnetization purging pulse elements at the end of the spin-echo sequence. Three methods, namely, trim-pulse, homospoil pulse gradient and chirp based z-filter were evaluated as potential candidates for an improved NMR diffusion method that is less sensitive to J-coupling peak distortion. The chirp based z-filter was found to be excellent in suppressing anti-phase magnetization while leaving the in-phase magnetization basically intact in spin-echo and stimulated-echo based experiments. The incorporation of chirp based z-filter into PGSE could allow diffusion analysis that would otherwise be impossible by conventional means.
Torres
Allan M
AM
Nanoscale Organisation and Dynamics Group, College of Health and Science, University of Western Sydney, Penrith South DC, NSW 1797, Australia. a.torres@uws.edu.au
Dela Cruz
Ruby
R
Price
William S
WS
D000465:Algorithms; D016477:Artifacts; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted