Synthesis, crystal structure, antibacterial assay and DNA binding activity of new binuclear Cu(II) complexes with bridging oxamidate.
Two new binuclear copper complexes, [Cu(2)(oxpn)(bpy)(pic)(H(2)O)](pic) (1) and [Cu(2)(oxpn)(Me(2)bpy)(pic)](pic) (2) [H(2)oxpn=N,N'-bis(3-aminopropyl)oxamide; Hpic=2,4,6-trinitrophenol; bpy=2,2'-bipyridine; Me(2)bpy=4,4'-dimethyl-2,2'-bipyridine], have been synthesized and characterized by elemental analyses, conductivity measurements, IR, UV-visible spectroscopy and single crystal X-ray analyses. Both complexes have similar molecular structures. In complex 1, the central two Cu(II) atoms are bridged by cis-oxpn(2-) with the Cu1-Cu2 separation of 5.221A and the polyhedron of each copper atom is a square-pyramid. Similarly, complex 2 is a cis-oxpn(2-)-bridged binuclear complex with the Cu1-Cu2 separation of 5.196A. Cu1(II) central atom situated in a tetrahedral geometry is four-coordinated and Cu(II) atom situated in a square-pyramidal geometry is five-coordinated. Hydrogen bonding interactions and pi-pi stacking interactions link the binuclear copper complex 1 or 2 into a 2D infinite network. The antibacterial assays indicate that the two complexes showed better activities than their ligands. The interactions of the two binuclear complexes with herring sperm DNA (HS-DNA) have been studied by UV absorption titration, fluorescence titration and viscosity measurements. The results suggest that the two binuclear complexes bind to HS-DNA via an intercalative mode.
Marine Drug and Food Institute, Ocean University of China, Yushan Road No. 5, Qingdao, Shandong 266003, PR China.
Yu-Lan
YL
Song
Yan-Tuan
YT
Li
Zhi-Yong
ZY
Wu
D001412:Bacillus subtilis / Q000187:drug effects; D003300:Copper / Q000737:chemistry / Q000378:metabolism*; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects; D005453:Fluorescence; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D014783:Viscosity
D009942:Organometallic Compounds; D003300:Copper; D004247:DNA