IVIVC of controlled release formulations: physiological-dynamical reasons for their failure.
Dokoumetzidis
A
A
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PT, UK.
Macheras
P
P
D000818:Animals; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004058:Diffusion; D004339:Drug Compounding; D017709:Fractals; D041981:Gastrointestinal Tract / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D008956:Models, Chemical; D017711:Nonlinear Dynamics; D010599:Pharmacokinetics; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
D003692:Delayed-Action Preparations