Effects of n-3 fatty acids on autoimmunity and osteoporosis.
Decreased consumption of n-3 fatty acids (FA) and diets rich in animal proteins, saturated fats and n-6 vegetable oils are associated with a higher incidence of cardiovascular disease (CVD), certain malignancies and autoimmune disorders such as rheumatoid arthritis and Systemic Lupus Erythematosus (SLE), and renal disease. Recent studies show that reduced calorie intake and supplementation of diet with n-3 FA delays the onset of autoimmune renal disease, primarily, due to increased antioxidant enzyme activities, decreased NF-kappaB activation and decreased IL-1, IL-6 and TNF-alpha mRNA expression in the kidney tissue. Studies in rodents show that addition of n-3 FA and soy protein to diet affords protection against bone loss induced by ovariectomy in mice due to NF-kappaB expression and decreased activation of osteoclasts. Together, the available evidence show that increased daily intake of dietary n-3 FA decreases the severity of autoimmune disorders, lessens the chance of developing CVD, and protects against bone loss during post-menopause.
Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229-7868, USA. fernandes@uthscsa.edu
Gabriel
G
Fernandes
Arunabh
A
Bhattacharya
Mizanur
M
Rahman
Khaliquz
K
Zaman
Jameela
J
Banu
D001327:Autoimmune Diseases / Q000453:epidemiology; D015551:Autoimmunity / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control; D004032:Diet; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005395:Fish Oils / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D004930:Inuit; D009369:Neoplasms / Q000453:epidemiology; D010024:Osteoporosis / Q000517:prevention & control*
D015525:Fatty Acids, Omega-3; D005395:Fish Oils