[Postprandial metabolic disorder].
Atherosclerotic diseases, such as myocardial infarction, are rising in incidence in Japan as well as in the Western countries, and postprandial metabolic disorders are drawing particular attention as a risk factor for their development. Again, it is known that there exist a population of patients whose fasting glucose and triglyceride levels are found to be within a normal range, but who present with hyperglycemia and hypertriglyceridemia postprandially, which has led to both postprandial hyperglycemia and hyperlipidemia becoming recognized as risk factors for cardiovascular disease. In recent years, there is a deepening of awareness that common pathological conditions underlying these diseases include visceral fat accumulation, insulin resistance, and decreased early insulin response, which can often be accounted for by the single concept of "postprandial metabolic disorders", which has important implications as an early therapeutic target for prevention of cardiovascular disease. Of note, it has been suggested that in early type 2 diabetes characterized by postprandial hyperglycemia, early insulin response is found to be decreased, often demonstrating a pattern of delayed and excessive insulin secretion (postprandial hyperinsulinemia), which is, in turn, often complicated by postprandial lipid metabolic disorder. In this paper, therefore, we would like to discuss how to evaluate, prevent and treat postprandial metabolic disorders in light of their pathological implications.
Mori
Yutaka
Y
Division of Diabetes and Endocrinology, Department of Internal Medicine, the Jikei University School of Medicine.
D002318:Cardiovascular Diseases / Q000209:etiology; D004435:Eating; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology*; D006949:Hyperlipidemias / Q000209:etiology*; D024821:Metabolic Syndrome / Q000209:etiology