[Experimental study of prostheses modified by three dimensions porous Ti combined bone morphogenetic proteins].
OBJECTIVE
To observe bone ingrowth of artificial femur which three dimensions (3-D) porous Ti combined bone morphogenetic proteins (BMPs) integrating on the prostheses surface in dogs.


METHODS
The prostheses integrated 3-D porous Ti on the surface, which combined BMPs directly or through FG, were implanted canine. And fluorescent labeling was done at 2, 5 weeks after that, and then the prostheses with femurs were taken out in 3, 6 weeks after operation. These specimens were treated, then observed through microscopy.


RESULTS
At 3 weeks, bone growing 1/2 of full thickness in 3-D porous Ti, but bone growing full thickness in 3-D porous Ti at 6 weeks. Bone formation was obviously higher at 6 weeks than at 3 weeks.


CONCLUSIONS
The prostheses modified 3-D porous Ti can accelerate osteogenesis and improve bone formation so that mechanical interlock and integration can be come true.
Department of Orthopaedics, General Hospital of People's Liberation Army, Beijing 100853, China.
Zhong-Li
ZL
Li
Yan
Y
Wang
Guo-Qiang
GQ
Zhang
Mi
M
Zhou
Jing
J
Xue
D000818:Animals; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D004285:Dogs; D005260:Female; D020007:Implants, Experimental; D008297:Male; D016062:Porosity; D014025:Titanium
D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D014025:Titanium