Effect of aminophylline on aspirin penetration into the central nervous system in rats.
This study investigated with the effect of aminophylline on the penetration of aspirin through the blood-brain barrier (BBB) into the central nervous system (CNS) in rats. Acetylsalycylic was injected into the right axillary artery, to avoid the drug affecting the peripheral organs before it reached the CNS. The test animals received subcutaneously (s.c.) aminophylline 30 min before aspirin injection, while the control animals received an equimolar dose of physiological solution s.c. At time intervals of 30, 60, 90, 120, and 240 s after aspirin injection, the animals were decapitated and blood samples from the left jugular vein, as well as samples from the brainstem, cerebellum and left and right cerebral hemispheres, were taken to determine aspirin concentrations in all of them by a standard method. It was found that aspirin concentrations in the CNS were even 30 times lower than in the blood, with the concentrations being higher in the brainstem and cerebellum than in the left and right hemispheres. The presence of aminophylline did not alter aspirin concentrations either in the blood or the brain, and therefore did not affect significantly the aspirin penetration through the BBB into the CNS.
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Novi Sad, Republic of Serbia.
Velibor
V
Vasović
Branko
B
Banić
Vida
V
Jakovljević
Zdenko
Z
Tomic
Vukica
V
Milic-Djordjevic
D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001692:Biological Transport; D001812:Blood-Brain Barrier / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002199:Capillary Permeability; D004347:Drug Interactions; D005260:Female; D007269:Injections, Intra-Arterial; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000628:Aminophylline; D001241:Aspirin