[Study on preventing effects of procyanidins on selenite cataract development in rats].
OBJECTIVE
To study the preventing effects of procyanidins (PC) on selenite cataract in rats and the time-effect relationship.


METHODS
Forty five SD rats were divided into three groups: control, model and experiment groups. The rats in the experiment group were fed additionally with the PC by 80 mg x kg(-1) when they were supplied the equal selenite with the model group. Five rats of each group were regularly sacrificed by bleeding from femoral artery at sixth, eleventh, sixteenth day and the level of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of all lenses was measured.


RESULTS
Compared with the model group, the level of the MDA in the experiment group at the eleventh day and the sixteenth day greatly decreased (P < 0.01). At the sixteenth day the level of the SOD and GSH-Px had an increase (P < 0.01), which showed its anti-oxygenation.


CONCLUSIONS
PC indicated the obvious inhibition in the development of the rat cataract. The treatment period was recommended at least for fifteen days.
The Chengdu Municipal Sixth People's Hospital, Chengdu 610051, China. xcheng@mail.sc.cninfo.net
Xuan
X
Cheng
Wei-Bo
WB
Cheng
Hao
H
Yan
Su-Cai
SC
Zhang
Yu
Y
Wang
D000818:Animals; D002386:Cataract / Q000139:chemically induced* / Q000517:prevention & control*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D044945:Proanthocyanidins / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D018038:Sodium Selenite / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
D044945:Proanthocyanidins; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D018038:Sodium Selenite