Increased serum levels of brain-derived neurotrophic factor in chronic institutionalized patients with schizophrenia.
There is a growing body of evidence implicating the neurotrophin brain-derived neurotrophic factor (BDNF) in the pathogenesis of schizophrenia. As circulating BDNF levels may reflect the BDNF levels in the brain, we assessed serum BDNF in 40 institutionalized schizophrenic patients and 20 healthy controls. Serum BNDF levels were significantly increased in schizophrenic patients when compared to control subjects (p<0.001). Interestingly, serum BDNF correlated positively with the clinical scores at the negative subscale of the positive and negative syndrome scale (PANSS) (r=0.41; p<0.01). Our results confirm the emergent literature on the involvement of BDNF in schizophrenia.
Reis
Helton José
HJ
Group of Neuroimmunology, Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Nicolato
Rodrigo
R
Barbosa
Izabela Guimarães
IG
Teixeira do Prado
Paulo Henrique
PH
Romano-Silva
Marco Aurélio
MA
Teixeira
Antonio Lucio
AL
D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D005260:Female; D006778:Hospitals, Psychiatric; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012559:Schizophrenia / Q000097:blood*
D019208:Brain-Derived Neurotrophic Factor