Novel fluorinated acridone derivatives. Part 1: synthesis and evaluation as potential anticancer agents.
We report on the synthesis of a novel series of fluorinated acridones from 5-trifluoromethyl-1,3-cyclohexanedione. The cytotoxic activities of the compounds were studied in several cancer cells. Compounds 9a, 9c, 9e, 9f, and 9h exhibited significant anticancer activities in selected cell lines. Compound 9c is the most active showing GI(50) that ranged in values from 0.13 to 26 microM, covering a wide range of cancer cell lines.
Department of Chemistry, Tennessee State University, 3500 John A. Merritt Boulevard, Nashville, TN 37209-1561, USA.
Olugbeminiyi O
OO
Fadeyi
Saudat T
ST
Adamson
E Lewis
EL
Myles
Cosmas O
CO
Okoro
D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry; D054831:Acridones; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004247:DNA / Q000737:chemistry; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005461:Fluorine / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D013329:Structure-Activity Relationship; D013997:Time Factors
D000166:Acridines; D054831:Acridones; D000970:Antineoplastic Agents; D005461:Fluorine; C041300:acridone; D004247:DNA