Gastric floating matrix tablets: design and optimization using combination of polymers.
The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing domperidone as a model drug. Box-Behnken design was employed in formulating the GFDDS with three polymers: hydroxypropyl methylcellulose K4M (HPMC K4M) (X1), Carbopol 934P (X2) and sodium alginate (X3), as independent variables. Floating lag time (FLT), total floating time (TFT), time required to release 50% of the drug (t50) and diffusion exponent (n) were selected as dependent variables. Seventeen formulations were prepared, dissolution data obtained was fitted to the power law and floating profiles were analyzed. HPMC loading was found to be significant for floating properties. Carbopol loading had a negative effect on floating properties but was found helpful in controlling the release rate of the drug. No significant effect of sodium alginate on floating properties was observed but it was important for gel formation. The quadratic mathematical model developed could be used to predict formulations with desired release and floating properties.
Prajapati
Shailesh T
ST
Department of Pharmaceutics, Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, India. stprajapati@gmail.com
Patel
Laxmanbhai D
LD
Patel
Dasharath M
DM
D000179:Acrylates / Q000737:chemistry; D000464:Alginates / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004058:Diffusion; D004294:Domperidone / Q000737:chemistry* / Q000378:metabolism; D018492:Dopamine Antagonists / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers; D004339:Drug Compounding; D005753:Gastric Mucosa / Q000378:metabolism; D005765:Gastrointestinal Agents / Q000737:chemistry* / Q000378:metabolism; D005782:Gels; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D065347:Hypromellose Derivatives; D007700:Kinetics; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D008956:Models, Chemical; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
D000179:Acrylates; D000464:Alginates; D003692:Delayed-Action Preparations; D018492:Dopamine Antagonists; D004337:Drug Carriers; D005765:Gastrointestinal Agents; D005782:Gels; D006603:Hexuronic Acids; D011108:Polymers; D013607:Tablets; D065347:Hypromellose Derivatives; D004294:Domperidone; D020723:Glucuronic Acid; D008747:Methylcellulose; C453622:carbopol 934P