Targeting the oncogene and kinome chaperone CDC37.
CDC37 is a molecular chaperone that physically stabilizes the catalytic domains found in protein kinases and is therefore a wide-spectrum regulator of protein phosphorylation. It is also an overexpressed oncoprotein that mediates carcinogenesis by stabilizing the compromised structures of mutant and/or overexpressed oncogenic kinases. Recent work shows that such dependency of malignant cells on increased CDC37 expression is a vulnerability that can be targeted in cancer by agents that deplete or inhibit CDC37. CDC37 is thus a candidate for broad-spectrum molecular cancer therapy.
Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
Phillip J
PJ
Gray
Thomas
T
Prince
Jinrong
J
Cheng
Mary Ann
MA
Stevenson
Stuart K
SK
Calderwood
D000970:Antineoplastic Agents / Q000494:pharmacology*; D018797:Cell Cycle Proteins / Q000187:drug effects* / Q000235:genetics; D018833:Chaperonins / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D009857:Oncogenes
D000970:Antineoplastic Agents; C498362:CDC37 protein, human; D018797:Cell Cycle Proteins; D018833:Chaperonins