Dendritic cells based immunotherapy of patient with chondrosarcoma--case report.
We present a case report of patient with intracranial chondrosarcoma and attempt to use vaccination of dendritic cells as the salvage therapy. To our knowledge, this is the first case report of DCs vaccination in the head and neck chondrosarcoma. Immunotherapy with allogeneic DCs stimulated with tumor cell lysates in this case was demonstrated to be feasible, safe and well tolerated. Unfortunately we did not observe any clinical or immune response during vaccination. CD4+ and CD8+ regulatory cells could be responsible for ineffectiveness of immunotherapy.
Tabarkiewicz
Jacek
J
Department of Clinical Immunology, Skubiszewski Medical University of Lublin, 20-095 Lublin, Poland. tabar@mp.pl
Radej
Sebastian
S
Hus
Iwona
I
Wasiak
Magdalena
M
Wdowiak
Paulina
P
Giannopoulos
Krzysztof
K
Piechnik
Beata
B
Kłos
Adam
A
Dmoszyńska
Anna
A
Rolinski
Jacek
J
D016827:CD8 Antigens / Q000276:immunology; D049109:Cell Proliferation; D002813:Chondrosarcoma / Q000150:complications / Q000276:immunology* / Q000628:therapy*; D003713:Dendritic Cells / Q000276:immunology*; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D051858:Forkhead Transcription Factors / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000150:complications / Q000276:immunology; D016130:Immunophenotyping; D007167:Immunotherapy; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology; D018950:Lipopolysaccharide Receptors / Q000276:immunology; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014611:Vaccination
D016827:CD8 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D053645:Interleukin-2 Receptor alpha Subunit; D018950:Lipopolysaccharide Receptors