[T-and B-cell immune response of lymph nodes and immunosuppression correlating with metastatic spread of stomach cancer].
A correlation was established in 708 stomach cancer patients between number of involved lymph nodes, on the one hand, and T- and B-cell immune response and morphological tumor pattern, on the other. That in turn significantly correlated with T-cell immune response and tumor localization. However, B-cell immune response and tumor size showed an inverse and less pronounced correlation with number of involved lymph nodes. Immunosuppression and metastatic spread are inter-connected; both quickly develop in succession in a node nearest to tumor and then continue invade. Immunosuppression is induced by tumor cytokines and innate regulatory T-cells which can either suppress or stimulate immune response, irrespective of tumor size.
Bugrov
V V
VV
Absaliatova
O V
OV
Savkova
R F
RF
Kozlova
N M
NM
D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000276:immunology* / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology*