Tumor cell metabolism imaging.
Molecular imaging of tumor metabolism has gained considerable interest, since preclinical studies have indicated a close relationship between the activation of various oncogenes and alterations of cellular metabolism. Furthermore, several clinical trials have shown that metabolic imaging can significantly impact patient management by improving tumor staging, restaging, radiation treatment planning, and monitoring of tumor response to therapy. In this review, we summarize recent data on the molecular mechanisms underlying the increased metabolic activity of cancer cells and discuss imaging techniques for studies of tumor glucose, lipid, and amino acid metabolism.
Plathow
Christian
C
Department of Nuclear Medicine, University of Freiburg, Freiburg, Germany.
Weber
Wolfgang A
WA
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D002471:Cell Transformation, Neoplastic / Q000378:metabolism* / Q000473:pathology; D022082:Cellular Structures / Q000378:metabolism; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008279:Magnetic Resonance Imaging; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D009857:Oncogenes / Q000502:physiology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
D000596:Amino Acids; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose