[Effects of volatile oil of Rhizoma zingiberis and other two kinds of volatile oil on percutaneous penetration of bullatine A via hairless mouse skin in vitro].
OBJECTIVE
To investigate the effects of volatile oils of Rhizoma Acori Tatarinowii (RAT), Semen Myristicae (SM) and Pericarpium Citri Reticulatae (PCR) on percutaneous penetration of bullatine A via hairless mouse skin in vitro.


METHODS
By an improved Franz diffusion, the effects of three kinds of volatile oils on the percutaneous penetration of bullatine A were observed and compared with Azone, and the cumulative amount of bullatine A was determined by HPLC.


RESULTS
The penetration enhancement ratios of bullatine A with 7% volatile oil RAT and SM, 5% volatile oil of PCR and 3% Azone were 6.52, 6.74, 2.18, 6.03, respectively.


CONCLUSIONS
The volatile oil of RAT, SM and PCR enhance permeation of bullatine A, effectively.
School of Pharmaceutics, Yunnan University of Traditional Chinese Medicine, Kunming 650200, China.
Yi-Cen
YC
Bai
Yan-Jie
YJ
Li
Yun-Shu
YS
Ma
D000279:Administration, Cutaneous; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism*; D012869:Skin Absorption / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile