Plasmablastic lymphoma affecting the lung and bone marrow with CD10 expression and t(8;14)(q24;q32) translocation.
Plasmablastic lymphoma is a rare variant of a diffuse, large B-cell lymphoma, which typically presents in the oral cavity in immunocompromised patients. In HIV positive patients, this tumor has a tendency to manifest in extramedullary sites. In this report, we document a rare instance in which this neoplasm besides affecting the bone marrow also involved the lung. In addition, the lymphoma in our case disclosed CD10 positivity on immunohistochemistry and t(8;14)(q24;q34) translocation on cytogenetic analysis, mimicking a Burkitt/atypical Burkitt lymphoma. The problems in diagnosis are discussed.
Department of Pathology Tan Tock Seng Hospital, Singapore. gzzckl@singnet.com.sg
Khoon Leong
KL
Chuah
Siok Bian
SB
Ng
Limei
L
Poon
Wai Ming
WM
Yap
D019046:Bone Marrow Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D002883:Chromosomes, Human, Pair 14; D002898:Chromosomes, Human, Pair 8; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015260:Neprilysin / Q000378:metabolism*; D014178:Translocation, Genetic / Q000235:genetics*
D015260:Neprilysin