Coordination of COPII vesicle trafficking by Sec23.
Coat protein complex II (COPII) is a multi-subunit protein complex responsible for the formation of membrane vesicles at the endoplasmic reticulum. The assembly of this complex on the endoplasmic reticulum membrane needs to be tightly regulated to ensure efficient and specific incorporation of cargo proteins into nascent vesicles. Recent studies of a genetic disease affecting COPII function, and a structural analysis of COPII subunit interactions emphasize the central role of the Sec23 subunit in COPII coat assembly. Similarly, the demonstration that Sec23 interacts physically and functionally with proteins involved in both vesicle tethering and the transport along microtubules indicates that the Sec23 subunit is crucially important in linking COPII vesicle formation to anterograde transport events.
Department of Molecular and Cell Biology, and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
J Christopher
JC
Fromme
Lelio
L
Orci
Randy
R
Schekman
D022181:COP-Coated Vesicles / Q000378:metabolism*; D000072159:Dynactin Complex; D005347:Fibroblasts / Q000378:metabolism; D020690:GTPase-Activating Proteins; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000378:metabolism; D000077614:Golgi Matrix Proteins; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D008854:Microscopy, Electron; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000737:chemistry; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D012867:Skin / Q000473:pathology
D000072159:Dynactin Complex; C108705:GORASP1 protein, human; D020690:GTPase-Activating Proteins; D000077614:Golgi Matrix Proteins; D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; C079037:SEC23 protein, S cerevisiae; C118289:SEC24 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins