Reaction of carboxylic acids and isonitriles in small spaces.
Reversible encapsulation complexes are applied to the reaction of isonitriles with carboxylic acids. Encapsulation facilitates these reactions by amplifying the concentration of reactants, arranging the acid and isonitrile in the appropriate orientations, isolating intermediates from bulk solution, and providing an organized solvent cage.
Hou
Jun-Li
JL
The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Ajami
Dariush
D
Rebek
Julius
J
D002264:Carboxylic Acids / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D008958:Models, Molecular; D009570:Nitriles / Q000737:chemistry*
D002264:Carboxylic Acids; D009570:Nitriles