CNS GLP-1 regulation of peripheral glucose homeostasis.
Current models hold that peripheral and CNS GLP-1 signaling operate as distinct systems whereby CNS GLP-1 regulates food intake and circulating GLP-1 regulates glucose homeostasis. There is accumulating evidence that the arcuate nucleus, an area of the CNS that regulates energy homeostasis, responds to hormones and nutrients to regulate glucose homeostasis as well. Recent data suggest that GLP-1 may be another signal acting on the arcuate to regulate glucose homeostasis challenging the conventional model of GLP-1 physiology. This review discusses the peripheral and central GLP-1 systems and presents a model whereby these systems are integrated in regulation of glucose homeostasis.
Sandoval
Darleen
D
Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA. Darleen.Sandoval@uc.edu
D000818:Animals; D001069:Appetite Regulation / Q000502:physiology; D001786:Blood Glucose / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D052216:Glucagon-Like Peptide 1 / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology
D001786:Blood Glucose; D052216:Glucagon-Like Peptide 1