The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function.
Vacuolar-type H+-ATPase (V-ATPase)-driven proton pumping and organellar acidification is essential for vesicular trafficking along both the exocytotic and endocytotic pathways of eukaryotic cells. Deficient function of V-ATPase and defects of vesicular acidification have been recently recognized as important mechanisms in a variety of human diseases and are emerging as potential therapeutic targets. In the past few years, significant progress has been made in our understanding of function, regulation, and the cell biological role of V-ATPase. Here, we will review these studies with emphasis on novel direct roles of V-ATPase in the regulation of vesicular trafficking events.
Program in Membrane Biology, Center for Systems Biology, Simches Research Center, CPZN No. 8212, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA. Marshansky.Vladimir@mgh.harvard.edu
Vladimir
V
Marshansky
Masamitsu
M
Futai
D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D022161:Transport Vesicles / Q000378:metabolism*; D025262:Vacuolar Proton-Translocating ATPases / Q000378:metabolism*
D025262:Vacuolar Proton-Translocating ATPases