Association of cannabis use with prodromal symptoms of psychosis in adolescence.
Recent interest has focused on the association between cannabis use and risk of psychosis. In the largest unselected, population-based study on this topic to date, we examined cannabis use and prodromal symptoms of psychosis at age 15-16 years among 6330 adolescents. Those who had tried cannabis (n=352; 5.6% of the total sample) were more likely to present three or more prodromal symptoms even after controlling for confounders including previous behavioural symptoms (OR=2.23; 95% CI 1.70-2.94). A dose-response effect was seen. We conclude that cannabis use is associated with prodromal symptoms of psychosis in adolescence.
Department of Psychiatry, University of Oulu, PO Box 5000, 90014 University of Oulu, Finland. jouko.miettunen@oulu.fi
Jouko
J
Miettunen
Sari
S
Törmänen
Graham K
GK
Murray
Peter B
PB
Jones
Pirjo
P
Mäki
Hanna
H
Ebeling
Irma
I
Moilanen
Anja
A
Taanila
Markus
M
Heinimaa
Matti
M
Joukamaa
Juha
J
Veijola
D000293:Adolescent; D002648:Child; D015331:Cohort Studies; D015986:Confounding Factors, Epidemiologic; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D008385:Marijuana Smoking / Q000009:adverse effects / Q000453:epidemiology / Q000523:psychology*; D011618:Psychotic Disorders / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors