BRCT domains: phosphopeptide binding and signaling modules.
The BRCA1 C-terminus (BRCT) domains are essential for the tumor suppressor function of BRCA1, and have been found in a variety of proteins from bacteria to men. Recent studies demonstrate that the BRCT domain constitutes a novel phosphopeptide binding region. In this review we seek to discuss the recent biochemical and structural data that have helped elucidate the molecular basis of BRCT domain function and BRCT-mediated interactions, with special emphasis on the role of phospho-specific interactions in key networks that regulate DNA repair. Finally we offer predictions on additional phospho-interacting BRCT domains and potential in vivo binding sites for several BRCT domains.
Rodriguez
Maria C
MC
1Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.
Songyang
Zhou
Z
D019313:BRCA1 Protein / Q000737:chemistry* / Q000502:physiology; D001943:Breast Neoplasms / Q000235:genetics; D002352:Carrier Proteins / Q000378:metabolism; D004268:DNA-Binding Proteins; D004706:Endodeoxyribonucleases; D005260:Female; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D056488:Histone Chaperones; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000235:genetics; D010446:Peptide Fragments / Q000737:chemistry*; D010748:Phosphopeptides / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology*; D010750:Phosphoproteins / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction
C520310:ABRAXAS1 protein, human; D019313:BRCA1 Protein; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D056488:Histone Chaperones; D009687:Nuclear Proteins; D010446:Peptide Fragments; D010748:Phosphopeptides; D010750:Phosphoproteins; C466234:UIMC1 protein, human; D004706:Endodeoxyribonucleases; C410741:RBBP8 protein, human