Disintegrins in health and disease.
Few of the proteins isolated and characterized from snake venom have proven to be more chemically diverse, exquisitely specific or promiscuously active than the family known as disintegrins. These small proteins have shown structural homology with hundreds of cell surface molecules from plants and animals other than snakes, and their precise mimicry of native receptor ligands speaks to evolutionary niches related to survival and geographic locale. Over 100 disintegrins have been named and studied, with the most recent efforts into molecular techniques providing significant clues to taxonomic relationships among four different snake families. Investigators have evaluated disintegrin applications in therapies for cancer, asthma, osteopenia and inappropriate angiogenesis. Crystal and NMR studies have confirmed hypotheses regarding ligand-receptor interactions while illuminating the complexities of structure-function evidence. Disintegrin chimeras with viruses, microbubbles and fluorescent labels have become useful tools in many investigations. While many disintegrin studies still involve platelets, previously unexplored interactions with glial cancer, T lymphocytes and the bacteria Yersinia have blazed new trails for this field. This review will summarize disintegrin investigations since 2003.
Department of Medical Technology, University of Delaware, 305G Willard Hall Education Building, Newark, DE 19716, USA. mclane@udel.edu
Mary Ann
MA
McLane
Torsten
T
Joerger
Alaa
A
Mahmoud
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D003461:Crystallography; D004194:Disease; D019483:Disintegrins / Q000737:chemistry / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use; D006262:Health; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D023421:Models, Animal; D009369:Neoplasms / Q000188:drug therapy
D019483:Disintegrins