Oxidative rearrangements of isobenzofurans: studies toward the synthesis of the ajudazols.
We present a new facet of isobenzofuran chemistry which allows for its efficient manipulation to generate biologically relevant entities. This methodology has been successfully applied toward the synthesis of ajudazol A.
Hobson
Stephen J
SJ
WestCHEM, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ, UK.
Parkin
Andrew
A
Marquez
Rodolfo
R
D001203:Ascomycota / Q000737:chemistry / Q000378:metabolism; D001572:Benzofurans / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction
D001572:Benzofurans; D001688:Biological Products; D003374:Coumarins; C105430:benzofuran