Glutathione: a novel treatment target in psychiatry.
There is accumulating evidence for oxidative stress mechanisms as common pathophysiological pathways in diverse psychiatric disorders, which offers novel treatment targets in oxidation biology systems. Of these the glutathione system has the most favourable theoretical foundation, given its dominance as the most generic of cellular antioxidants. Clinically, this hypothesis has been supported by several recently published studies that have reported on the efficacy of N-acetylcysteine, a glutathione precursor, in the treatment of various psychiatric disorders. This article outlines the multidimensional evidence that currently exists for oxidative stress mechanisms in psychiatric disorders and specifically discusses glutathione as a promising novel therapeutic target.
Berk
Michael
M
Department of Clinical and Biomedical Sciences, Barwon Health, University of Melbourne, Geelong, Victoria, Australia. mikebe@barwonhealth.org.au
Ng
Felicity
F
Dean
Olivia
O
Dodd
Seetal
S
Bush
Ashley I
AI
D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*
D005978:Glutathione