What are the respective host and parasite contributions to toxoplasmosis?
The toxoplasmosis pathogenesis mechanism is complex because parasite and host specificities are interrelated. Advances in fundamental research (including strain genotyping, analyzing the progeny from crosses of different strains and exploring the implication of epigenetic effects on the parasite) have contributed greatly to our current knowledge of this mechanism. At the same time new data on the clinical characteristics of the disease have come to light. For example, highly virulent strains have been isolated recently in immunocompetent patients, and some studies suggest that toxoplasmosis also might be implicated in brain disorders. These recent tools and discoveries are likely to cast new light on the pathogenicity of Toxoplasma parasites and provide the key to understanding this unique form of parasitism.
Laboratoire Adaptation et Pathogénie des Microorganismes, UMR 5163 CNRS-Université Joseph Fourier, Institut J. Roget, BP 170, 38042 Grenoble Cedex 9, France. dmaubon@chu-grenoble.fr
Danièle
D
Maubon
Daniel
D
Ajzenberg
Marie-Pierre
MP
Brenier-Pinchart
Marie-Laure
ML
Dardé
Hervé
H
Pelloux
D000818:Animals; D044127:Epigenesis, Genetic; D005838:Genotype; D006790:Host-Parasite Interactions / Q000502:physiology*; D006801:Humans; D014122:Toxoplasma / Q000235:genetics / Q000502:physiology*; D014123:Toxoplasmosis / Q000469:parasitology*