[Influence of borneol on nasal absorption of Ligustrazinee].
OBJECTIVE
To evaluate the influence of borneol on nasal absorption enhancement of ligustrazine.


METHODS
The rats were randomly divided into 3 groups: Xiongbing nasal spray group (group A), Chuanxiong nasal spray group (group B) and Xiongbing group by decoction intragastric administration (group C). All the rats were decapitated at several time points after administration. The whole brains of rats were taken to homogenate and detected the concentrations of ligustrazine.


RESULTS
Compared with group B and C, group A has its characteristics: quick absorption, quick distribution and quick excretion of ligustrazine.


CONCLUSIONS
Nasal administration is a quick-acting way for ischemic cerebral vessel insufficientia. Borneol promoted nasal absorption of ligustrazine into brain.
Liu
Yu-De
YD
Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China. liuyude@126.com
Sun
Han-Jin
HJ
Li
Rong
R
Wu
Wei
W
Chen
Hong-Gui
HG
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001892:Camphanes / Q000494:pharmacology*; D004333:Drug Administration Routes; D005260:Female; D007700:Kinetics; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*; D009666:Nose / Q000187:drug effects*; D011719:Pyrazines / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001892:Camphanes; D011719:Pyrazines; C022871:isoborneol; C017953:tetramethylpyrazine