[Receptors and mechanisms of neurotropic effects of cytokines and growth factors].
Cytokines and trophic factors (TF) are known to be involved not only into the immune processes but in majority cells, organs and physiological systems functional activity regulation as well as in pathological conditions. Cytokines and TF are shown to exert antagonistic effects on the brain, involved into local and systemic reactions modulation in response to CNS inflammation, infections and other types of injuries. Authors observed new data about cytokines and TF (particularly, the very biologically active among them - tumor necrosis factor-alpha and interleukin-1-beta) physico-chemical properties as the background for their neurotropic affects investigation. The contemporary data about cytokines and TF receptors, their interaction with neurotransmitters, penetration into the brain and their bioactivity regulation are reviewed.
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Oleinik
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Vast'ianov
D000818:Animals; D001692:Biological Transport; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D016207:Cytokines / Q000502:physiology*; D006801:Humans; D053583:Interleukin-1beta / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism; D011485:Protein Binding; D018121:Receptors, Cytokine / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D016207:Cytokines; C508585:IL1B protein, human; D053583:Interleukin-1beta; D018377:Neurotransmitter Agents; D018121:Receptors, Cytokine; D014409:Tumor Necrosis Factor-alpha