LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson's disease compared to late-onset patients.
The frequency of LRRK2 Gly2385Arg mutation in Hong Kong Chinese with early-onset (age < or =45 years) Parkinson's disease was identified and compared with late-onset patients (age >50 years) and controls. The mutation prevalence were 8.8, 8.3, and 0% for early-onset, late-onset, and controls, respectively. The mean age of onset among LRRK2 G2385R carriers was 42.7 years old for early-onset compared to 74.3 for late-onset patients. LRRK2 G2385R mutation appears to be as prevalent among early-onset as late-onset patients.
Department of Aged Care and Rehabilitation, Bankstown-Lidcombe Hospital, Locked bag 1600, Bankstown, NSW 2200, Australia. daniel.chan@sswahs.nsw.gov.au
Daniel Kam Yin
DK
Chan
Ping Wing
PW
Ng
Vincent
V
Mok
Jonas
J
Yeung
Zhi Ming
ZM
Fang
Raymond
R
Clarke
Edward
E
Leung
Lawrence
L
Wong
D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D015995:Prevalence; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
D005819:Genetic Markers; C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases