ER biogenesis: self-assembly of tubular topology by protein hairpins.
The structure of the endoplasmic reticulum (ER) depends on members of the reticulon and DP1/Yop1p families. Two of these proteins are sufficient to form tubular membrane networks from pure phospholipid vesicles, thus revealing a new paradigm of ER morphogenesis.
Shnyrova
Anna
A
Program on Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1855, USA.
Frolov
Vadim A
VA
Zimmerberg
Joshua
J
D004721:Endoplasmic Reticulum / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism; D008954:Models, Biological; D010743:Phospholipids / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D010743:Phospholipids; C505725:Rtn1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C426246:YOP1 protein, S cerevisiae