Neural regeneration and cell replacement: a view from the eye.
Neuronal degenerations in the retina are leading causes of blindness. Like most other areas of the CNS, the neurons of the mammalian retina are not replaced following degeneration. However, in nonmammalian vertebrates, endogenous repair processes restore neurons very efficiently, even after complete loss of the retina. We describe the phenomenon of retinal regeneration in nonmammalian vertebrates and attempts made in recent years to stimulate similar regenerative processes in the mammalian retina. In addition, we review the various strategies employed to replace lost neurons in the retina and the recent use of stem cell technologies to address problems of retinal repair.
Department of Biological Structure, University of Washington, Seattle, WA 98195, USA.
Deepak
D
Lamba
Mike
M
Karl
Thomas
T
Reh
D000663:Amphibians; D000818:Animals; D001717:Birds; D054338:Cell Transdifferentiation / Q000502:physiology; D064987:Cell- and Tissue-Based Therapy / Q000639:trends; D005399:Fishes; D006801:Humans; D051379:Mice; D009416:Nerve Regeneration; D009900:Optic Nerve / Q000502:physiology*; D012160:Retina / Q000166:cytology / Q000196:embryology / Q000254:growth & development / Q000637:transplantation; D012162:Retinal Degeneration / Q000145:classification / Q000209:etiology / Q000473:pathology* / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000639:trends