Increase in adult Clostridium difficile-related hospitalizations and case-fatality rate, United States, 2000-2005.
Virulence of and deaths from Clostridium difficile-associated disease (CDAD) are on the rise in the United States. The incidence of adult CDAD hospitalizations doubled from 5.5 cases per 10,000 population in 2000 to 11.2 in 2005, and the CDAD-related age-adjusted case-fatality rate rose from 1.2% in 2000 to 2.2% in 2004.
University of Massachusetts, Amherst, Massachusetts 01032, USA. marya@evimedgroup.org
Marya D
MD
Zilberberg
Andrew F
AF
Shorr
Marin H
MH
Kollef
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016360:Clostridioides difficile / Q000302:isolation & purification; D004761:Enterocolitis, Pseudomembranous / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D017052:Hospital Mortality / Q000639:trends*; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D016018:Least-Squares Analysis; D007902:Length of Stay; D008875:Middle Aged; D014481:United States / Q000453:epidemiology