[Effects of paclitaxel loaded ultrasound contrast agents on cell cycles and ultrastructural features of HepG2 cells].
OBJECTIVE
To investigate the effects of paclitaxel loaded ultrasound contrast agents on cell cycles and ultrastructural features of HepG2 cells.


METHODS
HepG2 cells were cultured, and divided into a blank control group, a paclitaxel group, an ultrasound contrast agents group, and a paclitaxel loaded ultrasound contrast agents group. Cell cycles of the four groups were detected by flow cytometry, and the ultrastructural changes of the cells were observed under a transmission electron microscope.


RESULTS
Paclitaxel loaded ultrasound contrast agents blocked the HepG2 cells at their G2/M phases, and it also induced more apoptosis of the HepG2 cells.


CONCLUSIONS
Paclitaxel loaded ultrasound contrast agents can block HepG2 cells at the G2/M phase and induce apoptosis of the cells.
Department of Gastroenterology, Second Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400010, China.
Yao
Y
Liu
Juan
J
Kang
Xiao-ling
XL
Wu
Zhi-gang
ZG
Wang
Zhao-xia
ZX
Wang
Pan
P
Li
D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D056945:Hep G2 Cells; D006801:Humans; D046529:Microscopy, Electron, Transmission; D017239:Paclitaxel / Q000494:pharmacology*
D003287:Contrast Media; D017239:Paclitaxel