Predictors of wheezing in prematurely born children.
OBJECTIVE
To examine the degree to which neonatal illness severity, postneonatal health problems, child characteristics, parenting quality as measured by the HOME Inventory, and maternal characteristics are related to the development of wheezing in prematurely born children over the first 27 months after term.


METHODS
Longitudinal predictive study.


METHODS
Infants were recruited from two neonatal intensive care units, one in southeast and one in Midwest.


METHODS
One hundred thirteen preterm infants who weighed less than 1,500 g or required mechanical ventilation and their mothers.


METHODS
The presence of wheezing was obtained from maternal report at 2, 6, 9, 13, 18, 22, and 27 months. Wheezing was considered to be medically significant if the child was using bronchodilators or pulmonary antiinflammatory medications.


RESULTS
Sixty-eight percent of the children had wheezing at least one or more ages; 47% of the children were also taking bronchodilators or pulmonary antiinflammatory medications and thus had medically significant wheezing.


CONCLUSIONS
Postneonatal health problems and the social environment appear to be more important in developing wheezing in prematurely born children than neonatal medical complications.
School of Nursing, Duke University, Durham, NC 27710, USA. diane.hd@duke.edu
Diane
D
Holditch-Davis
Piper
P
Merrill
Todd
T
Schwartz
Mark
M
Scher
D001249:Asthma / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D005865:Gestational Age; D006801:Humans; D006967:Hypersensitivity / Q000150:complications; D015994:Incidence; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D008137:Longitudinal Studies; D008297:Male; D015146:Midwestern United States / Q000453:epidemiology; D024802:Nurse's Role; D015403:Nursing Evaluation Research; D016487:Parenting; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012121:Respiration, Artificial / Q000009:adverse effects; D012135:Respiratory Sounds / Q000209:etiology*; D012141:Respiratory Tract Infections / Q000150:complications; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D012959:Socioeconomic Factors; D015144:Southeastern United States / Q000453:epidemiology