Biological approaches to ischemic tissue repair: gene- and cell-based strategies.
Gene therapy is a potential therapeutic strategy for treatment of ischemic vascular diseases; however, the clinical application of gene therapy has met some anticipated challenges. Recent randomized, controlled trials suggest that patients with cardiovascular disease may also benefit from cell-based therapies, and the optimal treatment regimen may combine both approaches to take advantage of potential synergy between the underlying therapeutic mechanisms. This review discusses recent research into both gene and cell therapy and considers the potential application of a combined treatment approach for cardiovascular and cerebrovascular ischemic diseases.
Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. j.roncalli@hotmail.fr
Jerome
J
Roncalli
Jörn
J
Tongers
Marie-Ange
MA
Renault
Douglas W
DW
Losordo
D000818:Animals; D001691:Biological Therapy / Q000379:methods; D002545:Brain Ischemia / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D002318:Cardiovascular Diseases / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D005260:Female; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome