[Treatment of myeloma in the elderly].
The treatment of elderly patients with multiple myeloma was based for the last forty years on the combination of alkeran plus prednisone. The survival was short. Three new molecules, thalidomide, bortezomib and revlimid are completely changing the way we treat myeloma as well as the prognosis. These new molecules are tested either alone or in combination. The addition of thalidomide to alkeran plus prednisone has increased overall survival of two years. For the first time, major therapeutic improvements are emerging giving rise to better prognosis.
Garderet
Laurent
L
Hôpital Saint-Antoine, service d'hématologie et de thérapie cellulaire, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France. laurent.garderet@sat.aphp.fr
Isnard
Françoise
F
Gorin
Norbert-Claude
NC
D000368:Aged; D000369:Aged, 80 and over; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D001897:Boronic Acids / Q000627:therapeutic use; D000069286:Bortezomib; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D000077269:Lenalidomide; D008558:Melphalan / Q000627:therapeutic use; D009101:Multiple Myeloma / Q000188:drug therapy / Q000628:therapy*; D019653:Myeloablative Agonists / Q000627:therapeutic use; D011719:Pyrazines / Q000627:therapeutic use; D013792:Thalidomide / Q000031:analogs & derivatives / Q000627:therapeutic use
D050071:Bone Density Conservation Agents; D001897:Boronic Acids; D004164:Diphosphonates; D019653:Myeloablative Agonists; D011719:Pyrazines; D013792:Thalidomide; D000069286:Bortezomib; D000077269:Lenalidomide; D008558:Melphalan