Clinical remission and histopathological resolution of nodular lesions in a patient with gamma3 heavy-chain deposition disease.
Heavy-chain deposition disease (HCDD) is a rare entity accompanying to nonamyloidotic monoclonal immunoglobulin deposition disease. We report a case of gamma3-HCDD in which follow-up biopsy could be done after complete remission was achieved by chemotherapy. Follow-up biopsy 2 years after initial biopsy showed remarkable diminution of both nodular glomerular lesions and IgG heavy-chain deposits. This is the first case report to indicate that the original structure of glomeruli in patients with HCDD could be restored within a few years by an appropriate treatment at an early stage of the disease.
Department of Nephrology, Iwate Prefectural Central Hospital, Morioka, Japan. sjunchuo-hp.pref.iwate.jp
J
J
Soma
Y
Y
Tsuchiya
T
T
Sakuma
H
H
Sato
D005260:Female; D006362:Heavy Chain Disease / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007142:Immunoglobulin gamma-Chains / Q000032:analysis*; D007678:Kidney Glomerulus; D008875:Middle Aged
D007142:Immunoglobulin gamma-Chains