Influence of combined exercise training on indices of obesity, diabetes and cardiovascular risk in type 2 diabetes patients.
OBJECTIVE
To investigate the influence of combined exercise training on indices of obesity, diabetes and cardiovascular risk in type 2 diabetes patients.


METHODS
A double-blind randomized controlled trial with patients receiving either combination (COM), endurance (END) or no training (C).


METHODS
Sint-Jozef hospital (Belgium), general practice (Holland).


METHODS
Forty-six type 2 diabetes patients (17 female, 29 male).


METHODS
COM versus END and C. Patients exercised for three months, three times a week for 1 hour.


METHODS
Six-minute walk test (6MW T), peak Vo(2), strength in upper and lower limbs, sit-to-stand, height, weight, body mass index, fat mass, glycosylated haemoglobin (HbA1c), glycaemia, triglycerides, high-density lipoprotein (HDL), total cholesterol and quality of life (General Health Survey Short Form (SF-36)).


RESULTS
COM had significant better results on sit-to-stand (P<0.05), 6MW T (P<0.01), strength in upper (P<0.001) and lower limbs (P<0.001) compared with C. A different evolution among COM and C was found for HbA1c (P<0.05) and cholesterol (P<0.01), both decreased in COM and increased in C. HDL increased in COM and decreased in C (P<0.01). END had significant higher results on the 6MW T (P<0.01) compared with C. Compared with END, COM had significantly higher results on strength in upper (P<0.01) and lower limbs (P<0.01). The evolution of SF-36 items was not significantly different between the three groups.


CONCLUSIONS
In diabetes type 2 patients, COM had significant better effects on indices of physical condition, diabetes and cardiovascular risk compared with C. Compared with END, COM gave a tendency towards better results, however more research with a larger number of participants is needed.
Lambers
Sabine
S
Revalidation Sciences and Physiotherapy Ghent, Belgium.
Van Laethem
Christophe
C
Van Acker
Kristien
K
Calders
Patrick
P
D000328:Adult; D000368:Aged; D001530:Belgium; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D004311:Double-Blind Method; D015444:Exercise; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000628:therapy*; D010807:Physical Endurance; D011788:Quality of Life; D012306:Risk; D016896:Treatment Outcome