Association between serum prostate-specific antigen level, liver function tests and lipid profile in healthy men.
OBJECTIVE
To assess the association between serum prostate-specific antigen (PSA) level and age, liver function tests (LFTs) including alkaline phosphatase (ALP), total bilirubin (TB), lipid profile (total cholesterol, TC, triglycerides, TG, high-density lipoprotein, HDL) and fasting blood sugar (FBS), and to determine the significant factors for predicting the serum PSA level in men with a low risk of having prostate cancer.


METHODS
In all, 38 157 healthy male employees of the Korea Electric Power Corporation (KEPCO) who were aged <60 years and had serum PSA levels of <4 ng/mL and serum creatinine levels of <1.4 mg/dL were enrolled between January 2002 and December 2006. Body weight and height were measured, and levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), ALP, TB, FBS, TC, TG, and HDL, and serum PSA were measured.


RESULTS
The mean (sd) age of the study population was 44.4 (7.90) years and the mean PSA level 0.89 (0.51) ng/mL. In a univariate analysis there were significant interrelations between serum PSA level and age, BMI, AST, ALT, ALP, TB, HDL and FBS (P < 0.05). The multiple logistic regression analyses using four percentiles (10th, 25th, 75th, 90th percentile) of serum PSA level showed trends that being older was associated with serum PSA level, and that BMI, ALT, HDL and FBS were negatively correlated with serum PSA level.


CONCLUSIONS
These results suggest that serum PSA level was significantly influenced by age, BMI, ALT, HDL and FBS. Further studies are needed to confirm our results and to explain the underlying mechanisms.
Han
June Hyun
JH
Department of Urology, Hanil General Hospital, KEPCA Medical Foundation, Seoul, Korea.
Chang
In Ho
IH
Ahn
Seung Hyun
SH
Kwon
Oh Jung
OJ
Bang
Seong Hak
SH
Choi
Nak Young
NY
Park
Sang Wook
SW
Myung
Soon Chul
SC
Kim
Hyun Woo
HW
D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D015331:Cohort Studies; D006304:Health Status; D006801:Humans; D008055:Lipids / Q000097:blood*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood*; D012307:Risk Factors; D055815:Young Adult
D001786:Blood Glucose; D008055:Lipids; D017430:Prostate-Specific Antigen