[Systemic lupus erythematosus and regulatory T cells].
A global depletion of FoxP3+ CD25(bright) CD4+ regulatory T cell is observed during lupus flares. This phenomenon is not the consequence of the relocalization of Tregs in diseased organs but could be related to their specific sensitivity to Fas mediated apoptosis. Several therapeutic perspectives can be drawn taking into account these pathophysiological insights.
Unité Inserm 543, CERVI, hôpital Pitié-Salpêtrière, CHU Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75013 Paris, France.
M
M
Miyara
Z
Z
Amoura
J-C
JC
Piette
G
G
Gorochov
D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*