Biphenylalkylacetylhydroquinone ethers suppress the proliferation of murine B16 melanoma cells.
Hydroquinone, an activator of caspase-9 activity via reactive oxygen species, and farnesol, a post-translational down-regulator of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity suppress the growth of murine 816 melanoma cells. Our previous studies have shown that farnesyl-O-acetylhydroquinone has a markedly greater growth-suppressive activity than that predicted by the responses to the parent compounds. Perillyl alcohol, a modulator of small G-protein activity, and biphenyl compounds, activators of Fas-mediated death pathways, suppress B16 growth. A similar synergistic increase in the potency of each compound when ether-linked to acetylhydroquinone is reported. Perillyl-O-acetylhydroquinone, biphenylethyl-O-acetylhydroquinone and biphenylpropyl-O-acetylhydroquinone had dose-dependent impacts on the proliferation of B16 cells with 50% inhibitory concentration (IC50) values of 8.0, 4.2 and 1.4 micromol/L, respectively. The growth-suppression effected by biphenylpropyl-O-acetylhydroquinone was accompanied by a dose-dependent arrest at the G1/S interface of the cell cycle, an impact greater than that previously reported for farnesyl-O-acetylhydroquinone (IC50 = 2.5 micromol/L). These new hydroquinone derivatives may have potential in cancer chemoprevention and/or therapy.
Fernandes
Nicolle
N
Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA.
Jung
Manfred
M
Daoud
Ali
A
Mo
Huanbiao
H
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001713:Biphenyl Compounds / Q000138:chemical synthesis*; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004987:Ethers / Q000138:chemical synthesis*; D006873:Hydroquinones / Q000138:chemical synthesis*; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice
D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D004987:Ethers; D006873:Hydroquinones; C031927:hydroquinone