Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline.
NAD(P)H dehydrogenase quinone 2 (NQO2) is a quinone reductase whose functions include the reduction of both oxidative stress during the redox cycle and neurotoxicity caused by the metabolism of catecholamines. We have investigated a functional non-synonymous exon 3 single nucleotide polymorphism (rs1143684) within the NQO2 gene for association with cognitive decline using a cohort of 722 community-dwelling older individuals aged 50 years and over. The volunteers had completed tests that measured fluid intelligence, processing speed, immediate/delayed verbal recall and semantic memory. We observed a nominal significant association between this polymorphism and the trajectory of delayed memory recall over time (p=0.029). No other associations were seen with the decline of other cognitive abilities.
Centre for Integrated Genomic Medical Research, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK. tony.payton@manchester.ac.uk
Antony
A
Payton
Fabio
F
Miyajima
William
W
Ollier
Patrick
P
Rabbitt
Andrew
A
Pickles
Volkmar
V
Weiss
Neil
N
Pendleton
Michael
M
Horan
D003072:Cognition Disorders / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D020125:Mutation, Missense; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D013997:Time Factors
D016660:NAD(P)H Dehydrogenase (Quinone)