Multiple ways of C/EBPalpha inhibition in myeloid leukaemia.
Transcription factors play a crucial role in myeloid differentiation and lineage determination. Tumour suppressor protein C/EBPalpha is a key regulator of granulocytic differentiation whose functional inactivation has become a pathophysiological signature of myeloid leukaemia. In this review we describe various mechanisms such as antagonistic protein-protein interaction, mutation and posttranslational modifications of C/EBPalpha which lead to its transcriptional inhibition and render C/EBPalpha inactive in its functions.
Trivedi
A K
AK
Drug Target Discovery and Development Division, Central Drug Research Institute (CDRI), Lucknow 226001, India. arun3vedi@cdri.res.in
Pal
P
P
Behre
G
G
Singh
S M
SM
D000208:Acute Disease; D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000037:antagonists & inhibitors*; D005544:Forecasting; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000378:metabolism
D022763:CCAAT-Enhancer-Binding Protein-alpha; D012333:RNA, Messenger