Training with inedible food in Aplysia causes expression of C/EBP in the buccal but not cerebral ganglion.
Training with inedible food in Aplysia increased expression of the transcription factor C/EBP in the buccal ganglia, which primarily have a motor function, but not in the cerebral or pleural ganglia. C/EBP mRNA increased immediately after training, as well as 1-2 h later. The increased expression of C/EBP protein lagged the increase in mRNA. Stimulating the lips and inducing feeding responses do not lead to long-term memory and did not cause increased C/EBP expression. Blocking polyADP-ribosylation, a process necessary for long-term memory after training, did not affect the increased C/EBP mRNA expression in the buccal ganglia.
The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel.
David
D
Levitan
Lisa C
LC
Lyons
Alexander
A
Perelman
Charity L
CL
Green
Benny
B
Motro
Arnold
A
Eskin
Abraham J
AJ
Susswein
D000818:Animals; D001048:Aplysia / Q000502:physiology*; D001245:Association Learning / Q000502:physiology*; D001921:Brain; D022762:CCAAT-Enhancer-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D005247:Feeding Behavior / Q000502:physiology*; D017952:Ganglia, Invertebrate / Q000502:physiology*; D005786:Gene Expression Regulation; D008568:Memory / Q000502:physiology; D009055:Mouth; D009928:Organ Specificity; D010812:Physical Stimulation; D011065:Poly(ADP-ribose) Polymerases; D012323:RNA Processing, Post-Transcriptional / Q000187:drug effects; D012333:RNA, Messenger / Q000096:biosynthesis
D022762:CCAAT-Enhancer-Binding Proteins; D012333:RNA, Messenger; D011065:Poly(ADP-ribose) Polymerases