Dynamic schema for near infrared detection of pressure-induced changes in solid tumors.
Differentiation among malignant tumors, benign tumors, and normal tissue is highly important in the diagnosis and treatment of many malignancies. We have proposed a dynamic schema for noninvasive characterization of pressure-induced changes in solid tumors. Our hypothesis has been that the altered neovascularization processes within cancer-bearing tissues may significantly increase vascular resistance and cause a much slower response of hemoglobin concentration during a dynamic compression stimulus. This hypothesis was tested by the evaluation of data generated from human tumor clinical testing and from animal tumor model testing. In the human tumor clinical testing, a unified diagnostic criterion was derived that integrated the relative characteristics of tumor oxygen, hemoglobin, and hemoglobin dynamics. By applying such a unified criterion, we were able to differentiate benign breast lesions and malignant breast tumors with high sensitivity and specificity within a subset of 14 suspicious breast lesions with similar size and depth characteristics. In the animal testing, a stepped compression load was applied to the subcutaneous tumor deposit on an athymic NU/NU nude mouse model with subcutaneous xenograft BxPC-3 cancer. Characteristic differences were observed between the premortem tumor and the postmortem tumor in terms of pressure-induced tumor structural and functional changes.
Wang
Bei
B
Department of Biomedical Engineering, Ohio State University, Columbus, OH 43210, USA.
Povoski
Stephen P
SP
Cao
Xianhua
X
Sun
Duxin
D
Xu
Ronald X
RX
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D019245:Compressive Strength; D004195:Disease Models, Animal; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D015233:Models, Statistical; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D055095:Optics and Photonics; D010100:Oxygen / Q000378:metabolism; D011312:Pressure; D011859:Radiography; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013997:Time Factors
D006454:Hemoglobins; D010100:Oxygen