Detailed visualization of the anterior segment using fourier-domain optical coherence tomography.
OBJECTIVE
To study details of the anterior chamber drainage angle using Fourier-domain optical coherence tomography in healthy subjects and patients with angle abnormalities.


METHODS
A high-speed anterior segment optical coherence tomography prototype was developed using a 1310-nm-wavelength swept light source. Six healthy subjects and 6 patients with glaucoma were imaged in an observational cross-sectional study.


RESULTS
Schlemm's canal and the trabecular meshwork were visualized in all of the patients. Fifteen-millimeter scans enabled entire anterior segment visualization providing configuration details of the iris with respect to the angle. Four-millimeter scans permitted detailed views of the angle configuration and its structures. Volumetric imaging was possible and Schlemm's canal was visualized along part of its circumference.


CONCLUSIONS
Anterior segment Fourier-domain optical coherence tomography permits detailed noncontact imaging of the angle and its structures, providing a tool to improve our understanding of the pathogenesis of narrow-angle glaucoma.
Asrani
Sanjay
S
Duke University Eye Center, Box 3802, Durham, NC 27710, USA. asran002@mc.duke.edu
Sarunic
Marinko
M
Santiago
Cecilia
C
Izatt
Joseph
J
D000328:Adult; D000869:Anterior Eye Segment / Q000473:pathology*; D003430:Cross-Sectional Studies; D005583:Fourier Analysis; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis*; D006068:Gonioscopy; D006801:Humans; D007498:Iris / Q000473:pathology; D008875:Middle Aged; D041623:Tomography, Optical Coherence / Q000379:methods*; D014129:Trabecular Meshwork / Q000473:pathology