Abiotrophia defectiva endocarditis and associated hemophagocytic syndrome--a first case report and review of the literature.
In this manuscript we describe the first association in the literature between Abiotrophia defectiva endocarditis and the hemophagocytic syndrome. There are multiple important clinical points of information that must be highlighted from this case. A. defectiva is an aggressive organism with a high level of resistance to antibiotic pharmacotherapy with a high predilection for embolic complications and valvular destruction despite treatment with sensitive antibiotics. A. defectiva endocarditis has not been previously associated with the hemophagocytic syndrome. However, this case highlights the serious hematological complications that can occur with this dangerous bacterial pathogen.
Kiernan
Thomas J
TJ
Department of Cardiology, The Adelaide and Meath Hospital, Dublin Incorporating the National Children's Hospital (AMNCH), Tallaght, Dublin 24, Ireland. tom_kiernan@hotmail.com
O'Flaherty
Niamh
N
Gilmore
Ruth
R
Ho
Emily
E
Hickey
Mary
M
Tolan
Michael
M
Mulcahy
David
D
Moore
David P
DP
D000328:Adult; D016063:Blood Loss, Surgical; D024901:Drug Resistance, Multiple, Bacterial; D004697:Endocarditis, Bacterial / Q000150:complications / Q000382:microbiology* / Q000601:surgery; D016908:Gram-Positive Bacterial Infections / Q000150:complications* / Q000188:drug therapy; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications / Q000382:microbiology*; D008297:Male; D008944:Mitral Valve Insufficiency / Q000382:microbiology / Q000601:surgery; D013289:Streptococcaceae / Q000302:isolation & purification*