Auxiliary substances and applicative properties of model dental gels with ketoprofen and therapeutic saline.
The aim of the study was to produce a model form of a drug of anti-inflammatory activity designed for application in oral cavity. An attempt was made to choose hydrogel vehicle which would ensure not only high pharmaceutical availability of the therapeutic agent but appropriate theological properties of the drug as well. Variant prescriptions with ketoprofen were worked out which differed in the kind of the used vehicle (xan than gum, guar gum, hydroxyethylcellulose, carboxymethylcellulose sodium salt). Introduction of polyelectrolyte solution of therapeutic salts in the form of iodic-bromic-boronic saline into the composition of the preparation aimed at not only optimizing the hydrogel therapeutic activity but also at increasing ketoprofen pharmaceutical availability. The process of ketoprofen release is most effective from a model form of a drug with cellulose derivatives (CMC-Na and HEC) being the hydrogel vehiculum in the quantity ratio 1:1. It is a system demonstrating appropriate theological properties such as: low value of yield stress and structural viscosity, insignificant water loss at 37 degrees C and good extensibility.
Department of Applied Pharmacy, Medical University of Lódź, 1 Muszyńskiego Str., 90-151 Lódź, Poland.
Justyna
J
Kołodziejska
Marian Mikołaj
MM
Zgoda
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D007660:Ketoprofen / Q000008:administration & dosage*; D014677:Pharmaceutical Vehicles; D012965:Sodium Chloride / Q000008:administration & dosage*; D014783:Viscosity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D020100:Hydrogels; D014677:Pharmaceutical Vehicles; D012965:Sodium Chloride; D007660:Ketoprofen