Cavity-enhanced optical frequency comb spectroscopy: application to human breath analysis.
Broad-bandwidth, high-spectral-resolution optical detection of human breath has identified multiple important biomarkers correlated with specific diseases and metabolic processes. This optical-frequency-comb-based breath analysis system comes with excellent performance in all criteria: high detection sensitivity, ability to identify and distinguish a large number of analytes, and simultaneous, real-time information processing. We demonstrate a minimum detectable absorption of 8 x 10(-10)cm(-1), a spectral resolution of 800 MHz, and 200 nm of spectral coverage from 1.5 to 1.7 microm where strong and unique molecular fingerprints exist for many biomarkers. We present a series of breath measurements including stable isotope ratios of CO(2), breath concentrations of CO, and the presence of trace concentrations of NH(3) in high concentrations of H(2)O.
Thorpe
Michael J
MJ
JILA, National Institute of Standards and Technology and University of Colorado, Boulder, CO 80309-0440, USA. thorpe@jilau1.Colorado.EDU
Balslev-Clausen
David
D
Kirchner
Matthew S
MS
Ye
Jun
J
D000641:Ammonia / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D001944:Breath Tests / Q000379:methods*; D002245:Carbon Dioxide / Q000032:analysis; D002248:Carbon Monoxide / Q000032:analysis; D006801:Humans; D013057:Spectrum Analysis / Q000379:methods; D014867:Water / Q000032:analysis
D015415:Biomarkers; D014867:Water; D002245:Carbon Dioxide; D000641:Ammonia; D002248:Carbon Monoxide