p53: The Janus of autophagy?
The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.
Beth
B
Levine
John
J
Abrams
D000818:Animals; D001343:Autophagy; D002471:Cell Transformation, Neoplastic; D005786:Gene Expression Regulation; D016158:Genes, p53; D016678:Genome; D006801:Humans; D008954:Models, Biological; D008957:Models, Genetic; D018384:Oxidative Stress; D010588:Phagosomes; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism / Q000502:physiology*
D016159:Tumor Suppressor Protein p53