Physico/chemical characterization and in vivo evaluation of nanothickness bioceramic depositions on alumina-blasted/acid-etched Ti-6Al-4V implant surfaces.
The objective of this study was to physico/chemically characterize and evaluate the in vivo performance of two nanothickness ion beam assisted depositions (IBAD) of bioceramic coatings on implants in a beagle model. Alumina-blasted/acid-etched (AB/AE) Ti-6Al-4V implants were subjected to two different IBAD depositions (IBAD I and IBAD II), which were physico/chemically characterized by SEM, EDS, XPS, XPS + ion-beam milling (depth profiling), XRD, AFM, and ToF-SIMS. A beagle dog tibia model was utilized for histomorphometric and biomechanical (torque) comparison between AB/AE, IBAD I, IBAD II, and plasma-sprayed hydroxyapatite (PSHA) coated implants that remained in vivo for 3 and 5 weeks. The coatings were characterized as amorphous Ca-P with high Ca/P stoichiometries with thicknesses of an order of magnitude difference (IBAD I = 30-50 nm and IBAD II = 300-500 nm). The histomorphometric and biomechanical testing results showed that the 300-500 nm thickness deposition (IBAD II) and PSHA positively modulated bone healing at early implantation times.
Department of Biomaterials and Biomimetics, New York University, 345 24th Street, Room 804a, New York, New York 10010, USA. pgcoelho@nyu.edu
Paulo G
PG
Coelho
Jack E
JE
Lemons
D000143:Acids / Q000737:chemistry; D000497:Alloys; D000537:Aluminum Oxide / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001696:Biomechanical Phenomena; D018786:Bone Substitutes; D002516:Ceramics / Q000737:chemistry*; D004285:Dogs; D017886:Durapatite / Q000737:chemistry; D017102:Fracture Healing; D008297:Male; D013314:Stress, Mechanical; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D019415:Torque
D000143:Acids; D000497:Alloys; D001672:Biocompatible Materials; D018786:Bone Substitutes; C031462:titanium alloy (TiAl6V4); D017886:Durapatite; D014025:Titanium; D000537:Aluminum Oxide