Lambert-Eaton syndrome with large-cell neuroendocrine carcinoma of the lung.
Lambert-Eaton syndrome (LES) is an immune-mediated disorder of the presynaptic neuromuscular junction due to the blocking effect of the voltage-gated calcium channel (VGCC) antibodies. Small-cell lung cancer (SCLC) is the most common cause of LES. We report an unusual case of LES associated with large-cell neuroendocrine carcinoma (LCNEC) of the lung. In this case, clinical symptoms of LES predated the diagnosis of LCNEC by 6 years. After tumor resection, the patient experienced clinical and electrophysiological improvement. In addition, he had a decrease in VGCC antibody titer from 130 to 80 pmol/L. The onset of LES can be prolonged, and tumor surveillance should continue in these cases.
The Neurological Institutes, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106-5040, USA.
Christian
C
Grommes
David C
DC
Preston
Zaid
Z
Al-Kadhimi
Amer
A
Alshekhlee
D000200:Action Potentials / Q000502:physiology; D018287:Carcinoma, Large Cell / Q000150:complications / Q000473:pathology* / Q000601:surgery; D004594:Electrophysiology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications / Q000473:pathology*; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D049268:Positron-Emission Tomography; D012881:Skin Temperature / Q000502:physiology; D012907:Smoking / Q000473:pathology; D014057:Tomography, X-Ray Computed
D019788:Fluorodeoxyglucose F18