Liver ultrastructural morphology and mitochondrial DNA levels in HIV/hepatitis C virus coinfection: no evidence of mitochondrial damage with highly active antiretroviral therapy.
Liver mitochondrial toxicity is a concern, particularly in HIV/hepatitis C virus (HCV) coinfection. Liver biopsies from HIV/HCV co-infected patients, 14 ON-highly active antiretroviral therapy (HAART) and nine OFF-HAART, were assessed by electron microscopy quantitative morphometric analyses. Hepatocytes tended to be larger ON-HAART than OFF-HAART (P = 0.05), but mitochondrial volume, cristae density, lipid volume, mitochondrial DNA and RNA levels were similar. We found no evidence of increased mitochondrial toxicity in individuals currently on HAART, suggesting that concomitant HAART should not delay HCV therapy.
Department of Pathology and Laboratory Medicine, University of British Columbia, Canada.
Motoi
M
Matsukura
Fanny F S
FF
Chu
May
M
Au
Helen
H
Lu
Jennifer
J
Chen
Sonja
S
Rietkerk
Rolando
R
Barrios
John D
JD
Farley
Julio S
JS
Montaner
Valentina C
VC
Montessori
David C
DC
Walker
Hélène C F
HC
Côté
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D015331:Cohort Studies; D004272:DNA, Mitochondrial / Q000648:ultrastructure*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000648:ultrastructure*
D004272:DNA, Mitochondrial