Effect of postural variations on carbon monoxide diffusing capacity in healthy subjects and patients with chronic obstructive pulmonary disease.
BACKGROUND
The scientific literature does not supply enough information about the effects of postural changes on diffusing lung capacity for carbon monoxide (DL(CO)) in patients with chronic obstructive pulmonary disease (COPD), in particular regarding the prone position.


OBJECTIVE
We evaluated posture-related changes in DL(CO) in healthy subjects and in COPD patients in order to especially assess how prone posture affects gas exchange.


METHODS
In this cross-sectional study, DL(CO) was measured in 10 healthy subjects and 30 COPD patients in standing, seated, supine and prone positions.


RESULTS
In healthy individuals, DL(CO) tended to improve from the upright to the supine position (21.42 +/- 2.90 and 26.07 +/- 5.11 ml/min/mm Hg, respectively); in the same group, changing the position from upright to prone also caused significant improvements in DL(CO) (absolute value, 21.42 +/- 2.90 vs. 24.80 +/- 4.39 ml/min/mm Hg, p < 0.05, or percent of predicted, 78.58 +/- 11.12 vs. 91.44 +/- 13.23, p < 0.05) and in DL(CO) proportional to alveolar volume (DL(CO)/VA; 4.52 +/- 0.57 vs. 5.66 +/- 1.48 ml/min/mm Hg/l, p < 0.05). No significant differences in DL(CO) have been observed in COPD patients from the standing to the prone position. Multivariate linear regression models showed that the posture-related changes in DL(CO), DL(CO) expressed as percent of predicted and in DL(CO)/VA are directly correlated with the transition from upright/sitting to supine/prone.


CONCLUSIONS
In healthy subjects, the effect of postural changes on DL(CO) could be explained by a more homogeneous perfusion, whereas the lack of variations in COPD patients could be attributed to the increased rigidity of lung capillaries, which could represent an early sensitive marker of damage of the alveolar capillary interface in these patients.
Terzano
Claudio
C
Department of Cardiovascular and Respiratory Sciences, Respiratory Diseases Unit, Sapienza University of Rome, Via Casal dé Pazzi 16, Rome, Italy. cterzano@tin.it
Conti
Vittoria
V
Petroianni
Angelo
A
Ceccarelli
Daniela
D
De Vito
Corrado
C
Villari
Paolo
P
D000328:Adult; D000368:Aged; D002248:Carbon Monoxide / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D016684:Prone Position; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism*; D011659:Pulmonary Gas Exchange; D016683:Supine Position
D002248:Carbon Monoxide