Genetic variability of the 45W gene family between Chinese and Mexican Taenia solium.
Taenia solium 45W proteins are good candidates for development of anti-cysticercosis vaccines. However, the genetic characteristics of the 45 gene family are still unclear between different isolates. We investigated the polymorphism of the 45 gene family between Chinese and Mexican T. solium. Alignment showed that TSO45-4B and TSO45-1C antigens were conserved absolutely, whereas other TSO45 proteins varied between these two isolates. It is informative to guide using of recombinant 45W vaccines to control porcine cysticercosis caused by Asiatic or African/Latin American T. solium.
Key Laboratory of Zoonoses of CAAS, Lanzhou, Gansu, China.
Yadong
Y
Zheng
Xuepeng
X
Cai
Xuenong
X
Luo
Dongfeng
D
Zhang
Zhizhong
Z
Jing
D000818:Animals; D000947:Antigens, Helminth / Q000737:chemistry / Q000276:immunology; D001483:Base Sequence; D003551:Cysticercosis / Q000517:prevention & control / Q000662:veterinary*; D017931:DNA Primers; D014644:Genetic Variation; D016133:Polymerase Chain Reaction; D013045:Species Specificity; D041201:Taenia solium / Q000145:classification / Q000235:genetics* / Q000276:immunology; D014612:Vaccines / Q000276:immunology
D000947:Antigens, Helminth; D017931:DNA Primers; D014612:Vaccines