Ca2+ signalling in the control of motility and guidance in mammalian sperm.
Ca2+ signalling in the sperm plays a key role in the regulation of events preceding fertilisation. Control of motility, including hyperactivation and chemotaxis, is particularly dependent upon [Ca2+]i signalling in the principal piece of the flagellum and the midpiece. Here we briefly review the processes that contribute to regulation of [Ca2+]i in mammalian sperm and then examine two areas: (i) the regulation of hyperactivation by [Ca2+]i and the pivotal roles played by CatSpers (sperm-specific, Ca2+-permeable membrane channels) and intracellular Ca2+ stores in this process and (ii) the elevation of [Ca2+]i and consequent modulation of motility caused by progesterone including the ability of progesterone at micromolar concentrations to cause sperm hyperactivation and/or accumulation and the recent discovery that progesterone, at picomolar concentrations, acts as a chemoattractant for mammalian sperm..
Publicover
Stephen John
SJ
School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. s.j.publicover@bham.ac.uk
Giojalas
Laura Cecilia
LC
Teves
Maria Eugenia
ME
de Oliveira
Gisela Sofia Mendes Machado
GS
Garcia
Aduen Andres Morales
AA
Barratt
Christopher Lowther Robert
CL
Harper
Claire Victoria
CV
D000818:Animals; D002118:Calcium / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D008297:Male; D008322:Mammals; D009712:Nucleotides, Cyclic / Q000502:physiology; D011374:Progesterone / Q000502:physiology; D015398:Signal Transduction; D013081:Sperm Motility / Q000502:physiology*; D013094:Spermatozoa / Q000502:physiology*
D009712:Nucleotides, Cyclic; D011374:Progesterone; D002118:Calcium