Dietary terpenoids and prostate cancer chemoprevention.
Cancer chemoprevention by phytochemicals may be one of the most feasible approaches for cancer control. Phytochemicals obtained from vegetables, fruits, spices, teas, herbs and medicinal plants, such as terpenoids and other phenolic compounds, have been proven to suppress experimental carcinogenesis in various organs in pre-clinical models. Recent studies have indicated that mechanisms underlying chemopreventive potential may be a combination of antioxidant, anti-inflammatory, immune-enhancing, and hormone modulation effects, with modification of drug metabolizing enzymes, influence on cell cycle and cell differentiation, induction of apoptosis, suppression of proliferation and angiogenesis playing roles in the initiation and secondary modification stages of neoplastic development. Specific features of prostate cancer, such as high prevalence and long latency period provides ample opportunities for chemopreventive agents to work at various stages of disease progression. Finally, suitable populations with appropriate risk factors, including the presence of pre-malignant lesions and genetic predispositions, need to be well characterized for future chemopreventive interventions. Here we review naturally occurring dietary terpenoids as useful agents for prostate cancer chemoprevention with reference to their classes and sources.
Department of Urology, Case Western Reserve University, University Hospitals, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA.
Thangaiyan
T
Rabi
Sanjay
S
Gupta
D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002338:Carotenoids / Q000008:administration & dosage / Q000627:therapeutic use; D002455:Cell Division / Q000187:drug effects; D018890:Chemoprevention / Q000379:methods; D004032:Diet; D004224:Diterpenes / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010641:Phenotype; D011471:Prostatic Neoplasms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D013729:Terpenes / Q000008:administration & dosage / Q000627:therapeutic use*; D014315:Triterpenes / Q000008:administration & dosage / Q000627:therapeutic use
D016588:Anticarcinogenic Agents; D004224:Diterpenes; D013729:Terpenes; D014315:Triterpenes; D002338:Carotenoids