[Organ specificity in nitric oxide storage in the blood vessel walls during adaptation to hypoxia].
Addition of N-acetylcysteine induced relaxation of the coronary and basilar arteries thus indicating some basilar NO-stores in these vessels. The maximum capacity of the NO-stores was similar in the coronary and the basilar arteries. Following adaptation to hypoxia, however, the depot was much greater in the coronary artery wall. This seems to be connected with different degree of participation of the NO-dependent vasodiatation in implementation of the adaptive response to hypoxia in coronary and cerebral vascular systems.
Manukhina
E B
EB
Kalenchuk
V U
VU
Gavrilova
S A
SA
Goriacheva
A V
AV
Malyshev
I Iu
IIu
Koshelev
V B
VB
D000111:Acetylcysteine / Q000494:pharmacology; D000222:Adaptation, Physiological; D000818:Animals; D001488:Basilar Artery / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D003331:Coronary Vessels / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D019335:Nitroarginine / Q000494:pharmacology; D009928:Organ Specificity; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*
D019335:Nitroarginine; D009569:Nitric Oxide; D012701:Serotonin; D019001:Nitric Oxide Synthase; D000111:Acetylcysteine