Catalytic Michael reactions of ketoesters with a camphor-derived acrylate equivalent: stereoselective access to all-carbon quaternary centers.
A camphor-based alpha'-hydroxy enone reagent acts as a chiral acrylate equivalent in copper-catalyzed Michael reactions of beta-keto esters and affords products that possess all-carbon quaternary stereocenters of high enantiomeric purity.
Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián, Spain. claudio.palomo@ehu.es
Claudio
C
Palomo
Mikel
M
Oiarbide
Jesús M
JM
García
Patricia
P
Bañuelos
José M
JM
Odriozola
Jesús
J
Razkin
Anthony
A
Linden