p53 regulation orchestrates the TGF-beta response.
Among its multiple functions, p53 is a critical regulator of TGF-beta responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectoderm germ layer and maintains the pluripotency of ectodermal cells by inhibiting TGF-beta target genes that promote mesoderm specification.
Piccolo
Stefano
S
Department of Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy. piccolo@bio.unipd.it
D000818:Animals; D002454:Cell Differentiation; D004475:Ectoderm / Q000166:cytology / Q000378:metabolism; D008648:Mesoderm / Q000166:cytology / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D014981:Xenopus / Q000196:embryology* / Q000378:metabolism
D016212:Transforming Growth Factor beta; D016159:Tumor Suppressor Protein p53