The emerging role of the Ikaros stem cell factor in the neuroendocrine system.
In this review, we cover the evidence implicating Ikaros as a key factor whose transcriptional actions and chromatin remodeling properties determine the fate of hypothalamic neuroendocrine and pituitary cell population expansion. We propose that the governing mechanisms involved in the regulation and action of Ikaros are of importance during developmental as well as neoplastic transitions.
Department of Medicine Department of Pathobiology, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
Shereen
S
Ezzat
Sylvia L
SL
Asa
D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival; D002490:Central Nervous System / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D051740:Ikaros Transcription Factor / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D009490:Neurosecretory Systems / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000378:metabolism / Q000502:physiology
D051740:Ikaros Transcription Factor