Multiple genetic alterations in vitamin K epoxide reductase complex subunit 1 gene (VKORC1) can explain the high dose requirement during oral anticoagulation in humans.
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L
Bodin
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J
Perdu
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M
Diry
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MH
Horellou
M-A
MA
Loriot
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D000925:Anticoagulants / Q000008:administration & dosage*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000235:genetics*; D020125:Mutation, Missense; D064417:Vitamin K Epoxide Reductases; D014859:Warfarin / Q000008:administration & dosage
D000925:Anticoagulants; D014859:Warfarin; D006899:Mixed Function Oxygenases; C578523:VKORC1 protein, human; D064417:Vitamin K Epoxide Reductases