Copacamphane, picrotoxane and cyclocopacamphane sesquiterpenes from Dendrobium nobile.
Dendronobilins K - N, four new sesquiterpenes with copacamphane-type (1), picrotoxane-type (2, 3) and cyclocopacamphane-type (4) skeletons, were isolated from the n-BuOH soluble fraction of the 60% ethanol extract of the stems of Dendrobium nobile. Their structures were established as 2beta,11,12-trihydroxycopacamphan-15-one (1), (2beta,3beta,4beta,5beta)-2,4,11,12-tetrahydroxypicrotoxan-3(15)-olactone (2), (2beta,3beta,5beta)-2,11,12,13-tetrahydroxypicrotoxan-3(15)-olactone (3), and (5beta,8beta)-cyclocopacamphane-5,8,12,15-tetrol (4) on the basis of spectroscopic analysis. Compounds 3 and 4 were inactive in both immunomodulatory and antioxidant bioassay in vitro.
Key Laboratory for Research & Development of New Drugs from Traditional Chinese Medicine & Natural Products in Shenzhen, Research Institute of Tsinghua University in Shenzhen, Shenzhen, PR China.
Xue
X
Zhang
Feng-Juan
FJ
Tu
Hai-Yang
HY
Yu
Nai-Li
NL
Wang
Zhao
Z
Wang
Xin-Sheng
XS
Yao
D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D002853:Chromatography, Liquid; D031667:Dendrobium / Q000737:chemistry*; D007155:Immunologic Factors / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000975:Antioxidants; D007155:Immunologic Factors; D010936:Plant Extracts; D012717:Sesquiterpenes