Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase.
Chronic granulomatous disease (CGD) is an immunodeficiency caused by the lack of the superoxide-producing phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. However, CGD patients not only suffer from recurrent infections, but also present with inflammatory, non-infectious conditions. Among the latter, granulomas figure prominently, which gave the name to the disease, and colitis, which is frequent and leads to a substantial morbidity. In this paper, we systematically review the inflammatory lesions in different organs of CGD patients and compare them to observations in CGD mouse models. In addition to the more classical inflammatory lesions, CGD patients and their relatives have increased frequency of autoimmune diseases, and CGD mice are arthritis-prone. Possible mechanisms involved in CGD hyperinflammation include decreased degradation of phagocytosed material, redox-dependent termination of proinflammatory mediators and/or signaling, as well as redox-dependent cross-talk between phagocytes and lymphocytes (e.g. defective tryptophan catabolism). As a conclusion from this review, we propose the existence of ROS high and ROS low inflammatory responses, which are triggered as a function of the level of reactive oxygen species and have specific characteristics in terms of physiology and pathophysiology.
Gastroenterology and Hepatology Unit, Department of Paediatrics, University Hospitals of Geneva, Geneva 4, Switzerland. Michela.Schaeppi@hcuge.ch
Michela G
MG
Schäppi
Vincent
V
Jaquet
Dominique C
DC
Belli
Karl-Heinz
KH
Krause
D000818:Animals; D006105:Granulomatous Disease, Chronic / Q000201:enzymology* / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000201:enzymology*; D051379:Mice; D019255:NADPH Oxidases / Q000276:immunology*
D019255:NADPH Oxidases