Negishi cross-couplings of unsaturated halides bearing relatively acidic hydrogen atoms with organozinc reagents.
A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated halides bearing an acidic NH or OH function, using Pd(OAc)(2) (1 mol %) and S-Phos (2 mol %) as catalyst without the need of protecting groups.
Manolikakes
Georg
G
Department Chemie and Biochemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 München, Germany.
Schade
Matthias A
MA
Hernandez
Carmen Muñoz
CM
Mayr
Herbert
H
Knochel
Paul
P