Clinical significance of intercellular adhesion molecule-1 in ulcerative colitis.
This study was conducted to assess the clinical significance of intercellular adhesion molecule-1 (ICAM-1) in ulcerative colitis (UC). The subjects were 53 cases of UC and 43 control cases. ICAM-1 was expressed to a greater degree in the UC specimens. Serum ICAM-1 concentrations in the UC group showed values that were lower than those in the control group (P = 0.0081). Serum ICAM-1 concentrations were found to vary according to degree of clinical severity, activity, and affected range. Considering the cases of surgery, there was only one case in which a lowering of early postoperative values was found. In all cases in which therapeutic drugs including steroids were not administered, late postoperative values were significantly increased. ICAM-1 dynamics in UC were frequently seen in tissue and exhibited a significantly low value in blood serum; however, the influence of clinical severity, activity, diseased area, measuring time, and therapeutic drugs need further study.
Department of Surgery II, Tokyo Women's Medical University School of Medicine, Tokyo, Japan. ogawanami@surg2.twmu.ac.jp
Nami
N
Ogawa
Noboru
N
Saito
Shingo
S
Kameoka
Makio
M
Kobayashi
D000293:Adolescent; D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000145:classification / Q000276:immunology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D018799:Intercellular Adhesion Molecule-1