[Osteonecrosis of the jaws: a secondary effect of bisphosphonates].
When treated with intravenous bisphosphonates to prevent bone resorption, 4-10% of the patients may develop osteonecrosis of the jaws a side effect. The osteonecrosis is usually preceded by an invasive dental procedure such as the removal of a tooth. Treatment of the osteonecrosis should be conservative using aseptic mouth rinses, oral antibiotics and small debridement. It seems advisable to have a dental check-up before starting using intravenous bisphosphonates, since a potential dental infections can be treated before the bone healing capacity is reduced by the bisphosphonates.
Schortinghuis
J
J
Chirurgien maxillo-facial en formation, Département de Chirurgie Maxillo-Faciale, Centre Médical Universitaire de Groningen. j.schortinghuis@kchir.umcg.nl
Meijndert
L
L
De Visscher
J G A M
JG
Witjes
M J H
MJ
D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003646:Debridement; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use; D019647:Oral Surgical Procedures / Q000009:adverse effects; D010020:Osteonecrosis / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy
D000890:Anti-Infective Agents; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D009067:Mouthwashes