[Effect of the combined hypertonic colloidal solution HyperHeas on hemodynamic and oxygen transport parameters, intracranial pressure, and cerebral oxygenation].
The paper gives the results of a clinical study of the effect of the new combined hypertonic colloidal and hypertonic solution HyperHaes (Frezenius-Cabi) on the parameters of systemic hemodynamics (invasive evaluation by means of a Swan-Ganz catheter), systemic oxygen transport, intracranial pressure (ICP) (lumbar spinal fluid pressure), and cerebral oximetry (INVOS 5100) in neurosurgical patients. The paradoxical effect was found as acute blood pressure lowering and elevated ICP on the beginning of solution infusion (the vasodilator effect of a distinctly hyperosmolar agent). In all other respects, HyperHaes is an ideal agent for volumetric compensation in neurosurgical patients.
Israelian
L A
LA
Lubnin
A Iu
AIu
D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002540:Cerebral Cortex / Q000098:blood supply / Q000378:metabolism; D006438:Hemodilution / Q000379:methods*; D006439:Hemodynamics / Q000187:drug effects*; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects*; D008970:Molecular Weight; D019635:Neurosurgical Procedures / Q000379:methods; D010100:Oxygen / Q000097:blood* / Q000378:metabolism; D010952:Plasma Substitutes / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D011446:Prospective Studies; D012462:Saline Solution, Hypertonic / Q000009:adverse effects / Q000494:pharmacology
D010952:Plasma Substitutes; D012462:Saline Solution, Hypertonic; D010100:Oxygen