Human herpesvirus 8 seroprevalence among children and adolescents in the United States.
We measured human herpesvirus-8 antibodies (K8.1 and orf73 enzyme immunoassays) in 4166 children, aged 6-17 years, in a U.S. cross-sectional survey. Forty-six were K8.1 seropositive (weighted seroprevalence: 1.1%) and 20 were orf73 seropositive (weighted seroprevalence 0.4%). K8.1 seropositivity was associated with asthma (odds ratio: 6.3; 95% confidence interval: 2.4-16.9) and hay fever (3.5; 1.1-11.0), and there were borderline associations with measures of crowding and low socioeconomic status.
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Lesley A
LA
Anderson
Yan
Y
Li
Barry I
BI
Graubard
Denise
D
Whitby
Georgina
G
Mbisa
Sylvia
S
Tan
James J
JJ
Goedert
Eric A
EA
Engels
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D001249:Asthma; D002648:Child; D003441:Crowding; D005260:Female; D006566:Herpesviridae Infections / Q000453:epidemiology* / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors; D014481:United States / Q000453:epidemiology
D000914:Antibodies, Viral