Feeding of Lactobacillus sobrius reduces Escherichia coli F4 levels in the gut and promotes growth of infected piglets.
The microbial community in the guts of mammals is often seen as an important potential target in therapeutic and preventive interventions. The aim of the present study was to determine whether enterotoxigenic Escherichia coli (ETEC) F4 infection in young animals might be counteracted by a probiotic treatment with Lactobacillus sobrius DSM 16698. The experiment was conducted in three randomized consecutive replications, each consisting of 16 piglets, and including a control group and an L. sobrius fed group, both experimentally challenged with ETEC. During the entire trial, the animals' health status, body weight, and microbial parameters were monitored periodically. Probiotic supplementation containing L. sobrius significantly reduced the levels of ETEC in the ileum when fed directly to piglets after weaning. In contrast, the number of days when the piglets had an increased faecal water content was significantly higher in the probiotic group. Nevertheless, an improved daily weight gain was also observed in the animals that received probiotic L. sobrius relative to the control fed group. The data indicate that L. sobrius may be effective in the reduction of the E. coli F4 colonization and may improve the weight gain of infected piglets.
Konstantinov
Sergey R
SR
Laboratory of Microbiology, Agrotechnology and Food Sciences Group, Wageningen University, The Netherlands. sergey.konstantinov@duke.edu
Smidt
Hauke
H
Akkermans
Antoon D L
AD
Casini
Luisa
L
Trevisi
Paolo
P
Mazzoni
Maurizio
M
De Filippi
Sara
S
Bosi
Paolo
P
de Vos
Willem M
WM
D000818:Animals; D001826:Body Fluids / Q000276:immunology; D015169:Colony Count, Microbial; D054307:Enterotoxigenic Escherichia coli / Q000254:growth & development / Q000302:isolation & purification / Q000502:physiology*; D004927:Escherichia coli Infections / Q000382:microbiology / Q000662:veterinary*; D005766:Gastrointestinal Contents / Q000737:chemistry; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006863:Hydrogen-Ion Concentration; D007085:Ilium / Q000382:microbiology; D007070:Immunoglobulin A / Q000032:analysis / Q000097:blood; D007778:Lactobacillus / Q000502:physiology*; D019936:Probiotics / Q000008:administration & dosage; D013552:Swine / Q000254:growth & development* / Q000276:immunology / Q000382:microbiology*; D013553:Swine Diseases / Q000382:microbiology* / Q000517:prevention & control
D007070:Immunoglobulin A