[Conjunctival bacterial flora after topical use of ciprofloxacin and gatifloxacin in cataract surgery].
OBJECTIVE
To evaluate alterations of the conjunctival flora after the use of 0.3% ciprofloxacin and gatifloxacin in the prophylaxis of patients undergoing cataract surgery.


METHODS
40 patients undergoing cataract surgery were distributed into two groups according to the use of antibiotic eye drops: Group A: 0.3% ciprofloxacin and Group B: 0.3% gatifloxacin. Both groups used antibiotic eye drops 1 hour before surgery and 14 days after surgery. Conjunctival material was collected at 5 time points: 1 hour before surgery, without any topical medication (t0); immediately before the application of povidone-iodine (PVPI) (t1), before the beginning of surgery, after povidone-iodine (t2), 14 days (t3) and 28 days after surgery (t4).


RESULTS
Preoperative antibiotics reduced the positivity of the cultures before the use of PVPI in both groups, although in Group A this reduction was not significant (Group A - p=0.07 and Group B - p=0.04). The number of positive cultures was reduced in all groups after the use of povidone-iodine and on the 14th postoperative day (p<0.05). In t4 there was a reduction in the frequency of coagulase-negative Staphylococcus in Group A compared with Group B (p<0.05); the susceptibility to ciprofloxacin was also reduced in all groups, when compared with t0.


CONCLUSIONS
Gatifloxacin eye drops applied one hour before surgery significantly reduced the number of positive conjunctival cultures. Both antibiotics reduced the conjunctival flora when administered in the postoperative period.
Arantes
Tiago Eugênio Faria E
TE
Fundação Altino Ventura, Recife, PE, Brasil. t_arantes@yahoo.com
Castro
Célia Maria Machado Barbosa de
CM
Cavalcanti
Ronald Fonseca
RF
Severo
Maiara Santos
MS
Diniz
Maria de Fátima Alves
Mde F
Urtiga
Ricardo Walber de Deus
RW
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D002387:Cataract Extraction; D002939:Ciprofloxacin / Q000627:therapeutic use*; D003228:Conjunctiva / Q000187:drug effects / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D009877:Endophthalmitis / Q000517:prevention & control; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use*; D000077734:Gatifloxacin; D006801:Humans; D008297:Male; D008875:Middle Aged; D011206:Povidone-Iodine / Q000627:therapeutic use*; D011300:Preoperative Care; D011446:Prospective Studies; D013210:Staphylococcus / Q000187:drug effects / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D011206:Povidone-Iodine; D000077734:Gatifloxacin