Desmoplastic fibroblastoma: a case presenting as a protruding nodule in the dermis.
Desmoplastic fibroblastoma is a rare, benign, soft tissue tumor. We describe a case of superficial desmoplastic fibroblastoma presenting as a protruding nodule. A 41-year-old woman presented with a painless, firm, elevated nodule with ulceration on her left thigh. Histological examination from total excision showed a well-circumscribed tumor in the dermis, which comprised of spindle, oval and stellate cells arranged in a haphazard fashion, accompanied by abundant collagenous stroma and inconspicuous vasculature. Immunohistochemically, the tumor cells were positive for vimentin, and focally positive for alpha-smooth muscle actin and muscle-specific actin, but negative for CD34, S-100 protein, desmin and beta-catenin. We diagnosed this case as desmoplastic fibroblastoma arising in the dermis and superficial subcutaneous tissue.
Takahara
Masakazu
M
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. mtakahara@dermatol.med.kyushu-u.ac.jp
Ichikawa
Ryutaro
R
Oda
Yoshinao
Y
Uchi
Hiroshi
H
Takeuchi
Satoshi
S
Moroi
Yoichi
Y
Kiryu
Hiromaro
H
Furue
Masutaka
M
D000328:Adult; D005350:Fibroma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology*; D013848:Thigh / Q000473:pathology