Alterations in DNA, RNA and protein contents in liver and kidney of mice treated with ochratoxin and their amelioration by Emblica officinalis aqueous extract.
The present investigation was an attempt to study ameliorative effect of Emblica officinalis aqueous extract on ochratoxin-induced toxicity on DNA, RNA and protein contents in liver and kidney of mice. Adult male albino mice were orally administered with 50 and 100 microg of ochratoxin/0.2 mL of olive oil/animal/day for 45 days. The results revealed significant (p < 0.05), dose-dependent decrease in the concentrations of DNA, RNA as well as total, acidic, basic and neutral protein contents in the liver and kidney of ochratoxin-treated mice. Administration of Emblica officinalis aqueous extract (2 mg/animal/day) for 45 days along with ochratoxin caused significant amelioration in the ochratoxin-induced reduction in DNA, RNA and protein contents in the liver and kidney of mice.
Verma
Ramtej
R
Toxicology Division, Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad 380 009, India. ramtejverma2000@yahoo.com
Chakraborty
Devjani
D
D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D009793:Ochratoxins / Q000008:administration & dosage / Q000633:toxicity*; D029842:Phyllanthus emblica / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D011506:Proteins / Q000187:drug effects / Q000378:metabolism; D012313:RNA / Q000187:drug effects / Q000378:metabolism
D002273:Carcinogens; D009793:Ochratoxins; D010936:Plant Extracts; D011506:Proteins; C025589:ochratoxin A; D012313:RNA; D004247:DNA