SURF imaging: in vivo demonstration of an ultrasound contrast agent detection technique.
A dual-band method for ultrasound contrast agent detection is demonstrated in vivo in an animal experiment using pigs. The method is named Second -order UltRasound Field Imaging, abbreviated SURF Imaging. It relies on simultaneously transmitting two ultrasound pulses with a large separation in frequency. Here, a low-frequency pulse of 0.9 MHz is combined with a high-frequency pulse of 7.5 MHz. The low-frequency pulse is used to manipulate the properties of the contrast agent, and the high frequency pulse is used for high-resolution contrast detection and imaging. An annular array capable of transmitting the low- and high-frequency pulses simultaneously was constructed and fitted to a mechanically scanned probe used in a GE Vingmed System 5 ultrasound scanner. The scanner was modified and adapted for the dual-band transmit technique. In-house software was written for post-processing of recorded IQ-data. Contrast-processed B-mode images of pig kidneys after bolus injections of 1 mL of Sonovuer are presented. The images display contrast detection with contrast-to-tissue ratios ranging from 15-40 dB. The results demonstrate the potential of SURF Imaging as an ultrasound contrast detection technique for clinically high ultrasound frequencies. This may allow ultrasound contrast imaging to be available for a wide range of applications.
Masoy
S E
SE
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway. svein-erik.masoy@ntnu.no
Standal
O
O
Nasholm
P
P
Johansen
T F
TF
Angelsen
Bjorn
B
Hansen
Rune
R
D000465:Algorithms; D000818:Animals; D003287:Contrast Media; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007668:Kidney / Q000000981:diagnostic imaging*; D010743:Phospholipids; D013459:Sulfur Hexafluoride; D013552:Swine; D014463:Ultrasonography / Q000379:methods*
D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride