Thymosin alpha 1 provides short-term and long-term benefits in the reimplantation of avulsed teeth: a double-blind randomized control pilot study.
BACKGROUND
This study investigates the short-term and long-term effects of thymosin alpha 1 (Talpha1) on reimplantation of avulsed teeth.


METHODS
Seventy-three patients with avulsed teeth were double-blind randomly assigned to a control group and group that used Talpha1. The teeth were reimplanted after treatment with Talpha1 or saline. Patients were monitored for both short-term and long-term parameters.


RESULTS
The thymosin group demonstrated a lower interferon, tumor necrosis factor alpha and interleukin-6 levels (P < .05) and higher white blood cell levels than the control group (P < .05). The thymosin group demonstrated greater periodontal healing (P < .05), less ankylosis (P < .05), less tooth movement, and greater lifetime of the replanted teeth.


CONCLUSIONS
The use of Talpha1 has both short-term and long-term beneficial effects during reimplantation of avulsed teeth.
Loo
Wings T Y
WT
Jinhua Dentistry, Kowloon, Hong Kong, People's Republic of China.
Dou
Y D
YD
Chou
W K J
WK
Wang
Min
M
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007372:Interferons / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D010865:Pilot Projects; D000077596:Thymalfasin; D013947:Thymosin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014084:Tooth Avulsion / Q000097:blood / Q000601:surgery*; D014090:Tooth Replantation / Q000379:methods*; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D000276:Adjuvants, Immunologic; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D013947:Thymosin; D007372:Interferons; D000077596:Thymalfasin