Viral diversity and dynamics in an infant gut.
Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.
Breitbart
Mya
M
College of Marine Sciences, University of South Florida, 140 Seventh Avenue South, Saint Petersburg, FL 33701, USA. mya@marine.usf.edu
Haynes
Matthew
M
Kelley
Scott
S
Angly
Florent
F
Edwards
Robert A
RA
Felts
Ben
B
Mahaffy
Joseph M
JM
Mueller
Jennifer
J
Nulton
James
J
Rayhawk
Steve
S
Rodriguez-Brito
Beltran
B
Salamon
Peter
P
Rohwer
Forest
F
D044822:Biodiversity; D004267:DNA Viruses / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification* / Q000648:ultrastructure; D004279:DNA, Viral / Q000235:genetics; D005243:Feces / Q000821:virology; D041981:Gastrointestinal Tract / Q000821:virology*; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000032:analysis; D008297:Male; D008969:Molecular Sequence Data; D020411:Oligonucleotide Array Sequence Analysis
D004279:DNA, Viral