Mechanobiology of tooth movement.
This review describes the mechanical and biological signalling pathways during orthodontic tooth movement and provides an update of the current literature. A theoretical model is introduced to elucidate the complex cascade of events after the application of an orthodontic force to a tooth. In this model, the events are divided into four stages: matrix strain and fluid flow, cell strain, cell activation and differentiation, and remodelling. Each stage is explained in detail and discussed using recent literature.
Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Centre, Postbus, Nijmegen, The Netherlands.
S
S
Henneman
J W
JW
Von den Hoff
J C
JC
Maltha
D000222:Adaptation, Physiological; D000539:Alveolar Process / Q000502:physiology*; D000818:Animals; D001696:Biomechanical Phenomena; D016723:Bone Remodeling / Q000502:physiology*; D006801:Humans; D008334:Mandible / Q000502:physiology; D008437:Maxilla / Q000502:physiology; D008954:Models, Biological; D010513:Periodontal Ligament / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014087:Tooth Movement Techniques