Colloidal metallic gold is not bio-inert.
Metallic gold (Au degrees ) is a likely biotransformation product of monovalent gold, Au(I) whenever it is dissociated from in vivo ligands, Au degrees being formed either by bioreduction or by spontaneous dismutation (with co-production of trivalent gold). This review discusses the preparation and some biologically relevant properties of colloidal metallic gold (CMG) in its nano-particulate form. Tyndall's purple, a well characterised preparation of CMG, shows potent anti-arthritic activity in rats, approximately 10(3) times that of sodium aurothiomalate (Myocrysin). Even more remarkable is its broader spectrum of action in rats compared to this classic DMARD.
Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Science, Griffith University, Brisbane, Qld., 4111, Australia. c.l.brown@griffith.edu.au
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Brown
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Whitehouse
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Bushell
D000818:Animals; D001168:Arthritis / Q000188:drug therapy; D017979:Gold Colloid / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D006801:Humans; D053768:Metal Nanoparticles
D017979:Gold Colloid