Hippocampal volume and 2-year outcome in depression.
Although the hippocampus has been found to be smaller in people with depression, the clinical relevance of this is unclear. We investigated hippocampal volume (using high-resolution magnetic resonance imaging) and 2-year outcome in 57 patients with major depression. The left and right hippocampal volumes of patients with a depression relapse were significantly smaller than those of healthy controls. Our results support the hypothesis that the hippocampus is crucial in the outcome of depression.
Department of Psychiatry, University of Heidelberg, Vossstrasse 4, Heidelberg 69115, Germany. klaus_kronmueller@med.uni-heidelberg.de
Klaus-Thomas
KT
Kronmüller
Johannes
J
Pantel
Sebastian
S
Köhler
Daniela
D
Victor
Frederik
F
Giesel
Vincent A
VA
Magnotta
Christoph
C
Mundt
Marco
M
Essig
Johannes
J
Schröder
D000293:Adolescent; D000328:Adult; D003865:Major Depressive Disorder / Q000473:pathology* / Q000503:physiopathology; D016021:Epidemiologic Studies; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012008:Recurrence; D012737:Sex Factors