Impact of spermine on down-regulation of Th2 cytokines in peripheral blood mononuclear cells from cedar pollinosis subjects in vitro.
The effects of spermine (SPM) on the production of Th1 and Th2 cytokines using peripheral blood mononuclear cells (PBMCs) derived from cedar pollinosis subjects were investigated. Th2 cytokines produced by PBMCs stimulated by 10 microM SPM was significantly lower than that in the controls. These findings indicate that blood SPM is an important factor in the Th1/Th2 balance.
Matsumoto
Mitsuharu
M
Dairy Science and Technology Institute, Kyodo Milk Industry Co., Ltd., Hinode, Tokyo 190-0182, Japan. m-matumoto@meito.co.jp
Kimata
Hiroichi
H
Benno
Yoshimi
Y
Kamio
Shigenori
S
D000328:Adult; D028203:Cedrus / Q000737:chemistry*; D016207:Cytokines / Q000096:biosynthesis*; D015536:Down-Regulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D006255:Rhinitis, Allergic, Seasonal / Q000378:metabolism*; D013096:Spermine / Q000494:pharmacology*; D018418:Th2 Cells / Q000187:drug effects* / Q000378:metabolism*
D016207:Cytokines; D013096:Spermine