Estrogen receptor gene 1 variants are not associated with suicidal behavior.
Estrogen is thought to be involved in the pathophysiology of depression and suicidal behaviors. We studied gene variants of estrogen receptor alpha (rs827421, rs1913474, rs1801132, rs722207, rs974276 and rs910416) in 167 German suicide attempters (affective spectrum n=107, schizophrenia spectrum n=35, borderline personality disorder n=25), 92 German individuals who committed suicide and 312 German healthy subjects. Single markers and haplotype analysis in relation to suicidal behaviors (suicide attempters/completers) did not reveal any significant association. These were also not associated with related features, such as violence or impulsivity of suicide attempt, State-Trait Anger Expression Inventory (STAXI) and Questionnaire for Measuring Factors of Aggression (FAF) scores. In conclusion, our study does not support the hypothesis that estrogen receptor alpha gene variants are major contributors to suicide or to anger- or aggression-related behaviors.
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany.
Ina
I
Giegling
Dan
D
Rujescu
Laura
L
Mandelli
Barbara
B
Schneider
Annette M
AM
Hartmann
Axel
A
Schnabel
Konrad
K
Maurer
Diana
D
De Ronchi
Hans-Jürgen
HJ
Möller
Alessandro
A
Serretti
D000328:Adult; D000368:Aged; D000374:Aggression / Q000502:physiology / Q000523:psychology; D000786:Anger / Q000502:physiology; D001883:Borderline Personality Disorder / Q000235:genetics; D035061:Control Groups; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005819:Genetic Markers; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D005858:Germany; D006239:Haplotypes; D006801:Humans; D007175:Impulsive Behavior / Q000235:genetics; D015810:Linkage Disequilibrium; D008875:Middle Aged; D010555:Personality Inventory / Q000706:statistics & numerical data; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics; D016728:Self-Injurious Behavior / Q000235:genetics; D013405:Suicide / Q000523:psychology / Q000706:statistics & numerical data*; D013406:Suicide, Attempted / Q000523:psychology / Q000706:statistics & numerical data
C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D005819:Genetic Markers