[Experimental study of prostheses modified by three dimensions porous Ti combined bone morphogenetic proteins].
OBJECTIVE
To observe bone ingrowth of artificial femur which three dimensions (3-D) porous Ti combined bone morphogenetic proteins (BMPs) integrating on the prostheses surface in dogs.


METHODS
The prostheses integrated 3-D porous Ti on the surface, which combined BMPs directly or through FG, were implanted canine. And fluorescent labeling was done at 2, 5 weeks after that, and then the prostheses with femurs were taken out in 3, 6 weeks after operation. These specimens were treated, then observed through microscopy.


RESULTS
At 3 weeks, bone growing 1/2 of full thickness in 3-D porous Ti, but bone growing full thickness in 3-D porous Ti at 6 weeks. Bone formation was obviously higher at 6 weeks than at 3 weeks.


CONCLUSIONS
The prostheses modified 3-D porous Ti can accelerate osteogenesis and improve bone formation so that mechanical interlock and integration can be come true.
Li
Zhong-Li
ZL
Department of Orthopaedics, General Hospital of People's Liberation Army, Beijing 100853, China.
Wang
Yan
Y
Zhang
Guo-Qiang
GQ
Zhou
Mi
M
Xue
Jing
J
D000818:Animals; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D004285:Dogs; D005260:Female; D020007:Implants, Experimental; D008297:Male; D016062:Porosity; D014025:Titanium
D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D014025:Titanium