Effects of atropine sulfate and neostigmine on gastric electrical activity in human subjects--electrogastrographic study.
OBJECTIVE
There are few reports about the cholinergic regulation of gastric electrical activities using percutaneous electrogastrograms (EGG). To determine the effect of intravenous administration of a vagal blocker (atropine sulfate) or a vagal stimulator (neostigmine) on gastric electrical activities EGG was utilized in this study.


METHODS
EGG was recorded before and after administration of a vagal blocker (atropine sulfate, 0.02mg/kg) and/or vagal stimulator (neostigmine, 0.008mg/kg) in six normal volunteers.


RESULTS
After administration of atropine sulfate, the original waves on EGG almost disappearedand decreased amplitudes were detected by visual inspection in all subjects. Moreover, increase amplitude on EGG was clearly demonstrated after administration of neostigmine in all subjects. It was also shown that the effects of these medicines persisted more than 60 minutes after injection.


CONCLUSIONS
These findings suggest that the EGG reflected gastric motility, and that neurological regulation of EGG was mediated through the vagal and/or cholinergic efferent pathway.
Department of Clinical Acupuncture and Moxibustion II, Meiji University of Oriental Medicine, Hiyoshi-cho, Kyoto, Japan. k_imai@meiji-u.ac.jp
Kenji
K
Imai
Hiroshi
H
Kitakoji
Eiichi
E
Chihara
Masakazu
M
Sakita
D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D004568:Electrodiagnosis / Q000379:methods*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D009388:Neostigmine / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects / Q000502:physiology*
D009388:Neostigmine; D001285:Atropine