Severe bladder contracture leading to cystectomy after intravesical mitoxantrone chemotherapy.
Since the early 1990s, mitoxantrone has been used as a chemotherapeutic agent for adjuvant intravesical treatment following transurethral resection of superficial transitional cell carcinomas of the bladder. Although its efficacy as adjuvant intravesical therapy remains questionable and its use has not gained wide acceptance, the safety profile of the drug has been reported as favorable. We report the first case of mitoxantrone-induced severe bladder contracture leading to a completely nonfunctional bladder after intravesical administration of the drug. Cystectomy and urinary diversion were the final consequences for the patient.
Department of Urology, Democritus University of Thrace, Dragana 68100, Alexandroupolis, Greece. stgian@otenet.gr
Stilianos
S
Giannakopoulos
Thrasivoulos
T
Pantazis
Christos
C
Kalaitzis
Dimitra
D
Antoniou
Emmanuel
E
Patris
Stavros
S
Touloupidis
D000283:Administration, Intravesical; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003286:Contracture / Q000139:chemically induced; D015653:Cystectomy; D005260:Female; D006801:Humans; D008942:Mitoxantrone / Q000009:adverse effects*; D012720:Severity of Illness Index; D001745:Urinary Bladder Diseases / Q000139:chemically induced* / Q000601:surgery
D000970:Antineoplastic Agents; D008942:Mitoxantrone