Salt restriction in kidney disease--a missed therapeutic opportunity?
The importance of salt restriction in the treatment of patients with renal disease has remained highly controversial. In the following we marshal the current evidence that salt plays a definite role in the genesis of hypertension and target organ damage, point to practical problems of salt restriction, and report on novel pathomechanisms of how salt affects blood pressure and causes target organ damage.
Department of Internal Medicine, Ruperto Carola University of Heidelberg, Nierenzentrum, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany. prof.e.ritz@t-online.de
Eberhard
E
Ritz
Otto
O
Mehls
D000293:Adolescent; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002301:Cardiac Glycosides / Q000235:genetics / Q000378:metabolism; D002648:Child; D002908:Chronic Disease; D018849:Controlled Clinical Trials as Topic; D004039:Diet, Sodium-Restricted; D004195:Disease Models, Animal; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D007674:Kidney Diseases / Q000178:diet therapy* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism
D002301:Cardiac Glycosides; D017673:Sodium Chloride, Dietary