Assigning the configuration of amino alcohols by NMR: a single derivatization method.
The chirality of sec/prim- and prim/sec-1,2-amino alcohols can be determined by (1)H NMR of just one MPA derivative--either (R) or (S)--by comparison of two spectra at different temperatures and analysis of the evolution of the easily observable singles of the CalphaH signals.
Leiro
Victoria
V
Departamento de Química Orgánica, Facultad de Química y Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.
Seco
José Manuel
JM
Quiñoá
Emilio
E
Riguera
Ricardo
R
D000605:Amino Alcohols / Q000032:analysis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015394:Molecular Structure; D013696:Temperature
D000605:Amino Alcohols