One hour effects of salbutamol and formoterol on blood pressure, heart rate and oxygen saturation in asthmatics.
OBJECTIVE
To analyse systolic (SBP) and diastolic blood pressure (DBP), partial oxygen saturation (SpO2) and heart rate (HR) disorders for an hour after short and long acting beta2-agonists.


METHODS
Twenty-four severe persistent asthma Pulmonology outpatients at Hospital Universitário Gaffrée e Guinle were selected. SBP, DBP, SpO2 and HR values were determined before and after 400 microg of salbutamol and 12 microg of formoterol, on different days, with a minimum interval of 24 hours.


RESULTS
All patients showed ventilatory obstruction, as seen by a reduced FEV1/FVC ratio. There was no statistical SBP/DBP/HR difference after bronchodilator agents, but SpO2 increased with salbutamol.


CONCLUSIONS
A standard dose of salbutamol and formoterol does not cause haemodynamic disorder.
Académico da Escola de Medicina e Cirurgia da Universidade Federal do Estado do Rio de Janeiro, UNIRIO Scientific Initiation Programme. jrcapuchinho@gmail.com
Geraldo
G
Andrade Capuchinho-Júnior
Ricardo
R
Marques Dias
Sônia
S
Regina da Silva de Carvalho
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000328:Adult; D000420:Albuterol / Q000494:pharmacology*; D001249:Asthma / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects*; D003430:Cross-Sectional Studies; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D000068759:Formoterol Fumarate; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D013997:Time Factors
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D000420:Albuterol; D010100:Oxygen; D000068759:Formoterol Fumarate