Adult T-cell leukemia/lymphoma in a patient from Romania: a case report and review of the literature.
Adult T-cell leukemia/lymphoma (ATLL) is a rare malignancy caused by human T-cell leukemia virus-1. ATLL is endemic to Japan, and to date, there are only four case reports of patients from Romania who have developed ATLL. Here, we describe a woman living in Madison, Wisconsin, originally from Romania, who presented with an atypical papulosquamous eruption and was ultimately diagnosed with smoldering ATLL. Narrow-band ultraviolet-B (UV-B) therapy and mid-potency topical steroids resulted in skin clearing for approximately 5 months after diagnosis; however, she subsequently relapsed with disease refractory to both narrow band UV-B and psoralen plus ultraviolet A (PUV-A), progressed to acute ATLL and expired secondary to complications.
Fett
Nicole M
NM
Department of Dermatology, University of Wisconsin and Veterans Affairs Medical Center, Madison, WI 53715, USA.
Siddiqui
Jawed
J
Creswell
Caleb H
CH
Zhang
Dahua
D
Lloyd
Rita
R
Wood
Gary S
GS
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D005260:Female; D005434:Flow Cytometry; D015490:HTLV-I Infections / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology* / Q000503:physiopathology* / Q000532:radiotherapy; D016133:Polymerase Chain Reaction; D012141:Respiratory Tract Infections / Q000473:pathology; D012383:Romania; D014467:Ultraviolet Therapy; D014820:Vitiligo / Q000473:pathology
D000305:Adrenal Cortex Hormones