Complications of lung cancer treatment.
In most cases lung cancer is incurable, but treatment is prolonging life for many and sustaining quality of life. Inevitably, disease-related symptoms develop with disease progression, and it can be difficult to differentiate these from treatment-induced complications. This is particularly true for pulmonary complications because tumor progression occurs most frequently in the lungs, and separating the effects of the disease from those induced by treatment (chemotherapy, radiotherapy) is often very difficult. This chapter identifies the main complications around surgical resection of lung cancer, highlighting the importance of expert postoperative care. For palliative treatments such as radiotherapy and chemotherapy, complications are related to the planned intensity of proposed therapy, the performance status of the patients, and patient age. Treatment of the elderly sufferer, now representing almost 50% of new cases, is poorly researched, but therapy-related complications are commoner in those aged over 70 years by ~20% when compared with their younger counterparts. Even during palliative care great attention has to be taken to minimize side effects of commonly used medications.
Spiro
Stephen G
SG
Department of Respiratory Medicine, University College London Hospitals, London, United Kingdom. stephen.spiro@uclh.nhs.org
Douse
Jonathan
J
Read
Catherine
C
Janes
Sam
S
D000367:Age Factors; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects*; D003131:Combined Modality Therapy / Q000009:adverse effects; D006801:Humans; D008168:Lung / Q000601:surgery; D055370:Lung Injury; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery*; D010166:Palliative Care; D011183:Postoperative Complications; D011788:Quality of Life; D011832:Radiation Injuries / Q000209:etiology; D016156:Respiratory Tract Fistula / Q000209:etiology; D012141:Respiratory Tract Infections / Q000209:etiology
D000970:Antineoplastic Agents