Metabolic syndrome and cognitive decline in chinese older adults: results from the singapore longitudinal ageing studies.
OBJECTIVE
To determine the association of the metabolic syndrome (MS) with cognitive decline in a Chinese older population.


METHODS
In a prospective cohort study of 1,352 community-living Chinese older adults without cognitive impairment (Mini Mental State Examination, MMSE <24) and without cardiovascular disease and stroke, the authors assessed baseline MS (defined according to International Diabetic Federation Criteria). Cognitive decline was predefined as at least 2-point drop in MMSE score at follow-up 1-2 years after baseline assessment.


RESULTS
MS was present in 26.3% of the participants at baseline and was significantly associated with the risk of cognitive decline (odds ratio, 1.42: confidence interval, 1.01-1.98), after controlling for potential confounding by age, gender, education, smoking, alcohol drinking, depressive symptoms, APOE-e4 status, level of leisure activities, baseline MMSE, and length of follow-up.


CONCLUSIONS
The MS was associated with increased risk of cognitive decline in Chinese older adults.
Department of Psychological Medicine, National University of Singapore, Singapore. pcmrhcm@nus.edu.sg
Roger C M
RC
Ho
Mathew
M
Niti
Keng Bee
KB
Yap
Ee Heok
EH
Kua
Tze-Pin
TP
Ng
D000368:Aged; D044466:Asian People / Q000523:psychology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000208:ethnology* / Q000523:psychology; D015331:Cohort Studies; D015897:Comorbidity; D003431:Cross-Cultural Comparison; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008609:Mental Status Schedule; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000208:ethnology* / Q000523:psychology; D008875:Middle Aged; D011446:Prospective Studies; D011594:Psychometrics; D012307:Risk Factors; D012846:Singapore