Organic-inorganic hybrid materials for efficient enantioseparation using cellulose 3,5-dimethylphenylcarbamate and tetraethyl orthosilicate.
The hybrid bead-type chiral packing material (CPM) for preparative enantioseparation has been prepared from the cellulose 3,5-dimethylphenylcarbamate containing a small number of 3-(triethoxysilyl)propyl groups in the presence of tetraethyl orthosilicate, by a sol-gel reaction in an aqueous surfactant solution. The obtained hybrid bead-type CPM was packed into a column and evaluated by high-performance liquid chromatography. When compared with the commercially available Chiralpak IB, which is prepared by the immobilization of cellulose 3,5-dimethylphenylcarbamate on silica gel, the hybrid bead-type CPM was shown to exhibit a similar chiral recognition and possess a higher loading capacity.
Ikai
Tomoyuki
T
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
Yamamoto
Chiyo
C
Kamigaito
Masami
M
Okamoto
Yoshio
Y
D002482:Cellulose / Q000737:chemistry* / Q000648:ultrastructure; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D048448:Phenylcarbamates / Q000737:chemistry*; D017640:Silicates / Q000737:chemistry*; D013237:Stereoisomerism
D048448:Phenylcarbamates; D017640:Silicates; D002482:Cellulose