[The associated study on apolipoprotein A5 gene polymorphisms with carotid artherosclerosis in patients with cerebral infartion].
OBJECTIVE
To investigate the association of -1131T>C and c.553G>T polymorphisms and their haplotypes in apolipoprotein A5(ApoA5) gene with cereberovascular disease in Chinese.


METHODS
Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), we analyzed two ApoA5 genetic variants in 272 patients with cerebral infarction (CI) and 316 control individuals respectively. The levels of serum lipid profiles were measured with biochemical methodsìand the other clinical characters were obtained by case file investigation.


RESULTS
The odds ratio (OR) for CI in -1131CC genotype carriers was 2.10 (95%CI 1.01-4.37). The distribution of T-T and T-G haplotypes had obvious differences between CI patients and control individuals. The OR for CI in C-G and T-G haplotype carriers were 1.34 and 0.71(95% CI 1.02-1.76 and 0.55-0.92) respectively, compared with the others. Furthermore, the major haplotypes had significant differences of serum TG(P< 0.05).


CONCLUSIONS
The ApoA5 -1131T>C polymorphism may be associated with an increased risk of CI in the Chinese population, but the influence of blood lipids can not be ignored.
Department of Medical Laboratory, Affiliated Drum Tower Hospital, the Medical School of Nanjing University, Nanjing, Jiangsu, 210008 People's Republic of China. zhangkui@yahoo.com.cn
Kui
K
Zhang
Fang
F
Qiu
Lei
L
Li
Guang-yu
GY
Gu
Yue
Y
Tao
Li
L
Wang
Xun-yang
XY
Luo
Yong-quan
YQ
Xia
D000368:Aged; D001054:Apolipoproteins A / Q000235:genetics*; D002340:Carotid Artery Diseases / Q000150:complications* / Q000235:genetics*; D002544:Cerebral Infarction / Q000150:complications* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
D001054:Apolipoproteins A