HIV Gag-specific immune responses predict the rate of CD4 decline.
In the present study, we assessed whether Gag-specific interferon (IFN)-gamma secreting responses correlate with the rate of disease progression as defined by the annual rate of CD4 decline. Although neither the breadth nor the magnitude of the proteome-wide HIV-specific IFN-gamma response correlated with viral load or rate of CD4 decline, the preferential targeting of Gag is associated with slower annual CD4 T cell decline.
Research Institute of McGill University Health Center, Montreal, Quebec, Canada.
Yoav
Y
Peretz
Christos M
CM
Tsoukas
Nicole F
NF
Bernard
D000293:Adolescent; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018450:Disease Progression; D015750:Genes, gag / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000378:metabolism*; D008231:Lymphopenia / Q000276:immunology*; D008875:Middle Aged; D019562:Viral Load
D007371:Interferon-gamma