Mechanobiology of tooth movement.
This review describes the mechanical and biological signalling pathways during orthodontic tooth movement and provides an update of the current literature. A theoretical model is introduced to elucidate the complex cascade of events after the application of an orthodontic force to a tooth. In this model, the events are divided into four stages: matrix strain and fluid flow, cell strain, cell activation and differentiation, and remodelling. Each stage is explained in detail and discussed using recent literature.
Henneman
S
S
Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Centre, Postbus, Nijmegen, The Netherlands.
Von den Hoff
J W
JW
Maltha
J C
JC
D000222:Adaptation, Physiological; D000539:Alveolar Process / Q000502:physiology*; D000818:Animals; D001696:Biomechanical Phenomena; D016723:Bone Remodeling / Q000502:physiology*; D006801:Humans; D008334:Mandible / Q000502:physiology; D008437:Maxilla / Q000502:physiology; D008954:Models, Biological; D010513:Periodontal Ligament / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014087:Tooth Movement Techniques