Role of secondary low-energy electrons in the concomitant chemoradiation therapy of cancer.
Solid films of DNA with and without the chemotherapeutic agent cisplatin bonded to guanine were bombarded with electrons of 1, 10, 100, and 60,000 eV causing single and double strand breaks. In the presence of cisplatin this damage was increased by factors varying from 1.3 to 4.4 owing to an increase in bond dissociation triggered by the formation of transient anions. This mechanism may lie at the basis of the efficiency of concomitant cisplatin-radiation therapy.
Zheng
Yi
Y
Département de Chimie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Hunting
Darel J
DJ
Ayotte
Patrick
P
Sanche
Léon
L
D002945:Cisplatin / Q000494:pharmacology*; D003131:Combined Modality Therapy; D004247:DNA / Q000187:drug effects / Q000528:radiation effects*; D018736:DNA Adducts; D004249:DNA Damage; D004273:DNA, Neoplasm / Q000187:drug effects / Q000528:radiation effects; D004277:DNA, Single-Stranded / Q000187:drug effects / Q000528:radiation effects; D004278:DNA, Superhelical / Q000187:drug effects / Q000528:radiation effects; D004583:Electrons; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000532:radiotherapy*
D018736:DNA Adducts; D004273:DNA, Neoplasm; D004277:DNA, Single-Stranded; D004278:DNA, Superhelical; D004247:DNA; D002945:Cisplatin