A one-pot coupling/hydrolysis/condensation process to pyrrolo[1,2-a]quinoxaline.
CuI/L-proline-catalyzed coupling of 2-halotrifluoroacetanilides with pyrrole-2-carboxylate esters in DMSO at 80-90 degrees C followed by in situ hydrolysis at 60 degrees C afforded pyrrolo[1,2-a]quinoxalines. Indole-2-carboxylate esters underwent the same process smoothly to provide the corresponding tetracyclic products.
Department of Chemistry, Fudan University, Shanghai 200433, China.
Qiliang
Q
Yuan
Dawei
D
Ma
D006868:Hydrolysis; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis*; D011810:Quinoxalines / Q000138:chemical synthesis*
D011758:Pyrroles; D011810:Quinoxalines; C531444:pyrrolo(1,2-a)quinoxaline