De-racemization of enantiomers versus de-epimerization of diastereomers--classification of dynamic kinetic asymmetric transformations (DYKAT).
The isolation of single stereoisomers from a racemic (or diastereomeric) mixture by enzymatic or chemical resolution techniques goes in hand with the disposal of 50% (racemate) or more (diastereomeric mixtures) of the "undesired" substrate isomer(s). In order to circumvent this drawback, dynamic systems have been developed for the de-racemization of enantiomers and the de-epimerizations of diastereomers. Key strategies within this area are discussed and are classified according to their underlying kinetics, that is, dynamic kinetic resolution (DKR), dynamic kinetic asymmetric transformations (DYKAT), and hybrids between both of them. Finally, two novel types of DYKAT are defined.
Research Center Applied Biocatalysis, Petersgasse 14, 8010 Graz, Austria. johannessteinreiber@gmx.net
Johannes
J
Steinreiber
Kurt
K
Faber
Herfried
H
Griengl
D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D002384:Catalysis; D004798:Enzymes / Q000737:chemistry; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D007700:Kinetics; D015394:Molecular Structure; D013237:Stereoisomerism; D013816:Thermodynamics
D000438:Alcohols; D000447:Aldehydes; D000596:Amino Acids; D004798:Enzymes; D004952:Esters; D007097:Imines; D007659:Ketones