Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: a neuropathological study.
An immunological function has been proposed for the choroid plexus (CP). In multiple sclerosis (MS) brains, CPs show (immunohistochemistry to HLA-DR, CD3, CD20, CD68, VCAM-1, CD138) T lymphocytes in vessels and stroma, VCAM-1 expression on endothelia, intense HLA-DR immunostaining on cells in CP stroma, among CP epithelium and on epiplexus cells. CPs in control or amyotrophic lateral sclerosis brains do not show such inflammatory changes. Intense CP inflammation is observed in viral encephalitis. Changes in MS CPs suggest persisting immune activation, with intensity similar to acute encephalitis, even in MS phases in which neurodegeneration prevails. In MS, CPs could represent a site for lymphocyte entry in the CSF and for CSF antigens presentation.
Vercellino
Marco
M
Department of Neuroscience, University of Turin, Italy.
Votta
Barbara
B
Condello
Cecilia
C
Piacentino
Chiara
C
Romagnolo
Alberto
A
Merola
Aristide
A
Capello
Elisabetta
E
Mancardi
Giovanni Luigi
GL
Mutani
Roberto
R
Giordana
Maria Teresa
MT
Cavalla
Paola
P
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis; D001927:Brain Diseases / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D002831:Choroid Plexus / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis
D015703:Antigens, CD; D006684:HLA-DR Antigens; D019010:Vascular Cell Adhesion Molecule-1