Malignant fibrous histiocytoma: between the past and the present.
The precise nature and diagnostic concept of malignant fibrous histiocytoma (MFH) has been debated for years. Currently, a histiocytic lineage of the tumor cells is no longer favored. The nomenclature and classification of MFH and its subtypes have also been changed. The MFH pattern, especially that of storiform-pleomorphic variant, is viewed as a morphologic pattern shared by a number of sarcomas as well as by other nonsarcomas. Therefore, a diagnosis of MFH based solely on morphology is no longer acceptable and identification of a line of differentiation should be sought. A diagnosis of MFH should be made only for pleomorphic sarcomas in which no specific line of differentiation is discerned. Precise categorization of MFH-like tumors may require thorough sampling of the tumor and judicious use of immunohistochemistry and/or electron microscopy. Familiarity with the current terminology and classification of MFH and its subtypes is of paramount significance in the modern practice of pathology.
Al-Agha
Osama M
OM
Department of Pathology, State University of New York,Downstate Medical Center at Brooklyn, USA. oalagha@healthcare.uiowa.edu
Igbokwe
Anne A
AA
D051677:Histiocytoma, Malignant Fibrous / Q000145:classification* / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D012983:Soft Tissue Neoplasms / Q000145:classification* / Q000175:diagnosis*