Poly(ADP-ribose) polymerase activity in different pathologies--the link to inflammation and infarction.
DNA repair and aging are two phenomena closely connected to each other. The poly(ADP-ribosyl)ation reaction has been implicated in both of them. Poly(ADP-ribose) was originally discovered as an enzymatic reaction product after DNA damage. Soon it became evident that it is necessary for regulation of different repair pathways. Also, evidence accumulated that poly(ADP-ribose) formation capacity is at least correlated with the life span of mammalian species. As a NAD(+)-consuming process, poly(ADP-ribosyl)ation can lead to cell death by energy depletion. This finding opened the area for investigation of poly(ADP-ribose) polymerase activity and polymer formation in pathologies. This review provides an introduction into the wide and complex field of poly(ADP-ribosyl)ation in different pathologies with regards of cell death regulation, inflammation and resulting tissue damage.
Beneke
Sascha
S
University of Konstanz, Molecular Toxicology Group, Universiteatsstr. 10, Box X911, 78457 Konstanz, Germany.
D000818:Animals; D002318:Cardiovascular Diseases / Q000201:enzymology; D016923:Cell Death / Q000502:physiology; D003920:Diabetes Mellitus / Q000201:enzymology; D006801:Humans; D007238:Infarction / Q000201:enzymology*; D007249:Inflammation / Q000201:enzymology*; D015212:Inflammatory Bowel Diseases / Q000201:enzymology; D008099:Liver / Q000098:blood supply; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D015427:Reperfusion Injury / Q000201:enzymology; D020521:Stroke / Q000201:enzymology
D011065:Poly(ADP-ribose) Polymerases