Rational design of cationic cyclooligosaccharides as efficient gene delivery systems.
Self-assembled cyclodextrin (CD)-DNA nanoparticles (CDplexes) exhibiting transfection efficiencies significantly higher than PEI-based polyplexes have been prepared from homogeneous seven-fold symmetric polyaminothiourea amphiphiles constructed on a beta-cyclodextrin scaffold.
Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, Isla de la Cartuja, E-41092, Sevilla, Spain.
Alejandro
A
Díaz-Moscoso
Patricia
P
Balbuena
Marta
M
Gómez-García
Carmen
C
Ortiz Mellet
Juan M
JM
Benito
Loïc
L
Le Gourriérec
Christophe
C
Di Giorgio
Pierre
P
Vierling
Antonino
A
Mazzaglia
Norberto
N
Micali
Jacques
J
Defaye
José M
JM
García Fernández
D002412:Cations / Q000737:chemistry; D018014:Gene Transfer Techniques; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature; D019076:Transgenes / Q000235:genetics*
D002412:Cations; D047028:Macrocyclic Compounds; D009844:Oligosaccharides