[Pharmacokinetic parameter and residua of 63Ni-NiCl2 in rat].
Absorption distribution and excretion of 63Ni-NiCl2, administered orally to rats were studied by using liquid scintillation counting method. It was observed that the concentration-time curves in blood fitted the two compartment model of pharmacokinetics, Ka=6.18 h(-1), T(1/2)alpha =0.79 h, T(1/2)beta=40.68 h, CL =0.42 mL kg(-1) h(-1), Tmax =0.53 h, Cmax=24,987.75 min(-1) mL(-1), and Vd=0.016 L kg(-1). After rats were treated by 63Ni-NiCl2 for 15 days, in 22 tissues tested, the contents of 63Ni-NiCl2 in hair, hypothalamus, hypophysis, pancreas, small and large intestines were higher, and the residua of 63Ni-NiCl2 was not discovered in liver, kidney and heart. Radioactivity eliminated was 83.27% by urine and feces, 54.86% by urine, 28.41% by feces.
School of Nuclear Science and Technology, Lanzhou 730000, China.
Zhan
Z
Li
Hao
H
Wang
Wang-Suo
WS
Wu
D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D005243:Feces / Q000737:chemistry; D005260:Female; D006197:Hair / Q000378:metabolism*; D009532:Nickel / Q000493:pharmacokinetics* / Q000652:urine; D011868:Radioisotopes / Q000493:pharmacokinetics* / Q000652:urine; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D011868:Radioisotopes; C022838:nickel chloride; D009532:Nickel