The compressive properties of bone cements containing large doses of antibiotics.
The addition of large amounts of antibiotics to bone cement provides a convenient local delivery, but may influence the compressive properties of the cement. Flucloxacillin and vancomycin were added to Simplex P (Stryker, Limerick, Ireland) and VersaBond (Smith & Nephew) cements. Tripling the antibiotic dose from 2 to 6 g had little effect on the static compressive properties 24 hours after curing. After 4 weeks in phosphate-buffered saline, there was marked decrease in properties with the addition of antibiotics. Compressive strength of cements with 6 g of antibiotic was reduced to near or below the ASTM and ISO minimum of 70 MPa after 4 weeks in phosphate-buffered saline. Microcomputer tomography revealed increased porosity and clumping of the radiopacifier with the addition of antibiotics.
Surgical & Orthopaedic Research Laboratories, Prince of Wales Hospital, University of New South Wales, Sydney, Australia.
Matthew H
MH
Pelletier
Lawrie
L
Malisano
Peter J
PJ
Smitham
Koji
K
Okamoto
William R
WR
Walsh
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001843:Bone Cements / Q000494:pharmacology*; D019245:Compressive Strength; D004347:Drug Interactions; D005436:Floxacillin / Q000494:pharmacology; D008422:Materials Testing; D020366:Methylmethacrylate / Q000494:pharmacology; D019904:Polymethyl Methacrylate / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001843:Bone Cements; C529141:versabond; D020366:Methylmethacrylate; D005436:Floxacillin; D014640:Vancomycin; D019904:Polymethyl Methacrylate