Sinonasal undifferentiated carcinoma with a frozen globe.
A 42-year-old previously healthy woman presented with a 5-week history of headache, facial numbness, proptosis, motility restriction, and visual loss. CT showed soft-tissue infiltration involving the posterior ethmoids, pterygopalatine fossa, and posterior inferior orbit. Histopathologic analysis of a biopsy specimen disclosed a highly aggressive and undifferentiated neoplasm with an immunophenotype and ultrastructural features consistent with an epithelial origin, which was most consistent with a diagnosis of sinonasal indifferentiated carcinoma. The tumor was unresectable and the patient was started on a course of radiation and chemotherapy.
Spitellie
Pete H
PH
Department of Ophthalmology, University of Ottawa Eye Institute, University of Ottawa and the Ottawa Hospital, Ottawa, Ontario, Canada.
Jordan
David R
DR
Brownstein
Seymour
S
Gooi
Patrick
P
Burns
Bruce
B
D000328:Adult; D001706:Biopsy; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D010255:Paranasal Sinus Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D014057:Tomography, X-Ray Computed