Porous silicon in drug delivery devices and materials.
Porous Si exhibits a number of properties that make it an attractive material for controlled drug delivery applications: The electrochemical synthesis allows construction of tailored pore sizes and volumes that are controllable from the scale of microns to nanometers; a number of convenient chemistries exist for the modification of porous Si surfaces that can be used to control the amount, identity, and in vivo release rate of drug payloads and the resorption rate of the porous host matrix; the material can be used as a template for organic and biopolymers, to prepare composites with a designed nanostructure; and finally, the optical properties of photonic structures prepared from this material provide a self-reporting feature that can be monitored in vivo. This paper reviews the preparation, chemistry, and properties of electrochemically prepared porous Si or SiO2 hosts relevant to drug delivery applications.
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.
Emily J
EJ
Anglin
Jacobs Retina Center at the Shiley Eye Center, Dept of Ophthalmology, University of California, San Diego, La Jolla, CA 92093, USA.
Lingyun
L
Cheng
Jacobs Retina Center at the Shiley Eye Center, Dept of Ophthalmology, University of California, San Diego, La Jolla, CA 92093, USA.
William R
WR
Freeman
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.
Michael J
MJ
Sailor
D000818:Animals; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods*; D004563:Electrochemistry; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D016062:Porosity; D012825:Silicon / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D012822:Silicon Dioxide; D012825:Silicon