Spontaneous regression of an EBV-associated monoclonal large B cell proliferation in the mastoid of a young child following surgical biopsy.
We report the spontaneous regression of an Epstein-Barr virus-associated monoclonal lymphoid proliferation in an immunocompetent child. A 2-year-old male with acute otitis media presented with a right-sided facial palsy secondary to acute mastoiditis. During mastoid decompression a polypoid mass, a histologically diffuse large B cell lymphoma, was found. Staging revealed localized disease. At surgical re-exploration 5 weeks later the disease had resolved. Retrospective serological testing was consistent with an acute Epstein-Barr viral infection and in situ hybridization of the tumour tissue was positive for Epstein-Barr RNA.
Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. m_g_mccabe@yahoo.com
Martin G
MG
McCabe
C Elizabeth
CE
Hook
G A Amos
GA
Burke
D001402:B-Lymphocytes / Q000166:cytology* / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D001706:Biopsy; D049109:Cell Proliferation; D002675:Child, Preschool; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D008297:Male; D008416:Mastoid / Q000166:cytology* / Q000000981:diagnostic imaging / Q000276:immunology; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed