[Chemical constituents from stems of Schisandra propinqua].
OBJECTIVE
To study the chemical constituents in the stems of Schisandra propinqua and evaluate their effects on proliferation of vascular smooth muscle cells (VSMCs) in vitro by MTT assay.


METHODS
The compounds were isolated and purified by various column chromatographic techniques and their structures were elucidated on the basis of spectral analysis (ESI-MS, 1H-NMR, 13C-NMR).


RESULTS
Five compounds were isolated and identified as galgravin (1), veraguensin (2), octadecanoic acid 2, 3-dihydroxypropyl ester (3), hexadecanoic acid 2, 3-dihydroxypropy ester (4), tetracosanoic acid 2, 3-dihydroxypropyl ester (5).


CONCLUSIONS
All the compounds were isolated for the first time from the plant. 1, 2, 5 showed inhibiting effects on vascular smooth muscle cell (VSMCs) proliferation in vitro.
Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100094, China.
Li-Jia
LJ
Xu
Hai-Tao
HT
Liu
Yong
Y
Peng
Wei
W
Xiao
Shi-Lin
SL
Chen
Si-Bao
SB
Chen
Pei-Gen
PG
Xiao
D005663:Furans / Q000737:chemistry; D017705:Lignans / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D018547:Plant Stems / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D005663:Furans; D017705:Lignans; C084077:galgravin