Activation of functional arylzincs prepared from aryl iodides and highly enantioselective addition to aldehydes.
An easily available chiral ligand ( S)- 1 is found to activate the nucleophilic reaction of the arylzincs prepared in situ from the reaction of aryl iodides with Et(2)Zn. Both high yields and high enantioselectivity (up to >99% ee) for the reaction of these arylzincs with a variety of aldehydes are obtained. The mild reaction conditions and the good functional group tolerance make this catalytic asymmetric process synthetically useful.
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319, USA.
Albert M
AM
DeBerardinis
Mark
M
Turlington
Lin
L
Pu