Pregnancy, chimerism and lupus nephritis: a multi-centre study.
Chimerism occurs twice as often in the kidneys of women with lupus nephritis as in normal kidneys and may be involved in the pathogenesis of systemic lupus erythematosus. Pregnancy is considered the most important source of chimerism, but the exact relationship between pregnancy, the persistence of chimeric cells and the development of systemic lupus erythematosus has not been investigated. Renal biopsies and clinical data from patients in the First Dutch Lupus Nephritis Study were used. Chimeric cells were identified by in-situ hybridization of the Y chromosome. A questionnaire was used to obtain detailed reproductive data including pregnancy history and miscarriages. Chimerism was found in 12 of 26 (46%) renal biopsies. Of the 12 chimeric women, 5 reported a pregnancy; of 14 women who were not chimeric, 8 reported a pregnancy. Chimeric women who had been pregnant reported significantly more pregnancies than non-chimeric women who had been pregnant (P=0.04). The median age of the youngest child was higher in chimeric women (19 years) than in non-chimeric women (6 years). Despite the attention given to pregnancy histories with respect to chimerism, this study shows that in patients with systemic lupus erythematosus, a clear-cut relationship is not apparent. A considerable number of chimeric women did not report a pregnancy: in these women, other sources of chimerism must be considered. Our data support the theory that only certain subsets of chimeric cells persist into the maternal circulation after pregnancy.
Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. i.c.l.kremer-hovinga@lumc.nl
I C L
IC
Kremer Hovinga
M
M
Koopmans
C
C
Grootscholten
A M
AM
van der Wal
M
M
Bijl
R H W M
RH
Derksen
A E
AE
Voskuyl
E
E
de Heer
J A
JA
Bruijn
J H M
JH
Berden
I M
IM
Bajema
D000293:Adolescent; D000328:Adult; D000818:Animals; D001706:Biopsy; D046528:Chimerism; D041322:Chromosomes, Human, Y; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D007668:Kidney / Q000473:pathology / Q000502:physiology; D008181:Lupus Nephritis / Q000235:genetics* / Q000503:physiopathology; D008875:Middle Aged; D011247:Pregnancy