Protective role of DC-SIGN (CD209) neck-region alleles with <5 repeat units in HIV-1 transmission.
To investigate the role that DC-SIGN neck-region length variation plays in HIV-1 transmission, we studied 530 HIV-1-positive and 341 HIV-1-negative individuals in China. The carrier frequency of a DC-SIGN allele with <5 repeat units in the neck-region was 0.9% in HIV-1-positive and 3.8% in HIV-1-negative individuals (P=.007), an observation suggesting that this DC-SIGN variation plays a role in HIV-1 transmission. These naturally occurring DC-SIGN neck-region variants were significantly more frequent in the Chinese population than in the US population (P <.001) and in a worldwide population (P=.006).
Institute for AIDS Prevention and Control, Shandong Center for Disease Control and Prevention, Shandong, China.
Jing
J
Zhang
Xinsheng
X
Zhang
Jihua
J
Fu
Zhenqiang
Z
Bi
Kristopher L
KL
Arheart
Luis B
LB
Barreiro
Lluis
L
Quintana-Murci
Savita
S
Pahwa
Huanliang
H
Liu
D000483:Alleles; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000235:genetics*; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D015658:HIV Infections / Q000235:genetics / Q000635:transmission*; D015497:HIV-1; D006801:Humans; D037181:Lectins, C-Type / Q000737:chemistry / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin