[Impaired insulin signaling and human ageing].
Human ageing is associated with impaired insulin activity, which may lead to alterations in energy homeostasis and type 2 diabetes. In addition, increasing evidence suggests that type 2 diabetes-associated hyperglycemia and hyperinsulinemia may accelerate cellular senescence. On the other hand, impaired insulin signaling in animal models extends organismal lifespan and interventions that promote longevity prevent metabolic alterations and diabetes. Here, we review the mechanisms underlying the development of age-associated hyperglycemia, its impact on cellular senescence and the effect of insulin-signaling pathways on energy balance and ageing.
Katedra i Zakład Patofi zjologii Uniwersytetu Medycznego w Poznaniu.
Krzysztof
K
Ksiazek
Janusz
J
Witowski
D000091162:AMP-Activated Protein Kinase Kinases; D000375:Aging / Q000502:physiology*; D000818:Animals; D016922:Cellular Senescence / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004734:Energy Metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008136:Longevity / Q000502:physiology; D011494:Protein Kinases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D011972:Receptor, Insulin / Q000378:metabolism; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D017127:Glycation End Products, Advanced; D007328:Insulin; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha; D007334:Insulin-Like Growth Factor I; D011494:Protein Kinases; D011972:Receptor, Insulin; D000091162:AMP-Activated Protein Kinase Kinases