Low-fluoride dentifrice and the effect of postbrushing rinsing on fluoride availability in saliva.
OBJECTIVE
Post-brushing water rinsing may reduce the risk of fluoride (F) ingestion from dentifrice, however the decreased salivary F bioavailability may compromise any consequent anticaries benefits. As the use of low-F concentration dentifrices is still a matter of debate, a comparison was made between the salivary F bioavailability after brushing with a conventional F dentifrice followed by a water rinse and after brushing with a low-F dentifrice without post-brushing rinse.


METHODS
In a crossover, blind study, F concentration in saliva of 5 adult volunteers was determined after brushing with a low-F dentifrice (500 microg F/g) or with a conventional F concentration dentifrice (1100 microg F/g), followed or not by a 15-mL water rinse.


RESULTS
Salivary F bioavailability was reduced by 2.5 times when a water rinse was used (p<0.05), irrespective of dentifrice concentration, and it was 2 times lower for the low-F dentifrice (p<0.05). The salivary F bioavailability was similar when the low-F dentifrice was used without post-brushing rinse and the conventional F dentifrice was followed by a rinse (p>0.05).


CONCLUSIONS
Habits of post-brushing rinse should be taken into account on the recommendation of dentifrice use by young children, considering the risks and benefits balance of F use.
Faculty of Dentistry of Piracicaba, UNICAMP, Piracicaba, SP, Brazil.
C B
CB
Zamataro
L M A
LM
Tenuta
J A
JA
Cury
D000328:Adult; D019540:Area Under Curve; D001682:Biological Availability; D002327:Cariostatic Agents / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics; D018592:Cross-Over Studies; D003802:Dentifrices / Q000008:administration & dosage / Q000627:therapeutic use*; D005459:Fluorides / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics; D006801:Humans; D017736:Ion-Selective Electrodes; D009067:Mouthwashes / Q000627:therapeutic use*; D012463:Saliva / Q000737:chemistry / Q000378:metabolism*; D016037:Single-Blind Method; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D013997:Time Factors; D014099:Toothbrushing / Q000379:methods*; D014867:Water
D002327:Cariostatic Agents; D003802:Dentifrices; D009067:Mouthwashes; D014867:Water; D012969:Sodium Fluoride; D005459:Fluorides