[Evaluation of hepatocellular function influenced by Chinese drug Dahuang Zhechong pill].
OBJECTIVE
To evaluate the influence of Chinese drug Dahuang Zhechong pill on the hepatocellular function.


METHODS
Thirty-seven patients with hepatocirrhosis and twelve normal controls were performed the hepatobiliary scintgraphy with Tc-99m labeled ethylene hepatobiliary iminodiacetic acid (99 mTc-EHIDA), and the biochemical examination of hepatic function. There was 19 cases repeated the imaging after 6 months treated with chineses drug. By the three compartmental model configurations, the function parameters of hepatocellular extraction and excretion were calculated.


RESULTS
In the hepatocirrhosis groups, the hepatocellular uptake peak time and mean residence index were higher than those in normal controls (P < 0.01). Compared to normal controls, the uptake index, uptake speed index and descendent speed index were decreased markedly (P < 0.05). After treatment for 6 months with Chinese drug, the level of serum transaminase, globulin and bilirubin was lower than that before treatment. The uptake peak time and mean residence index decreased notably after treatment for 6 months (P < 0.01), and the uptake index increased, (P < 0.05).


CONCLUSIONS
Chinese drug Dahuang Zhechong pill may improve the hepatocellular function and liver function status in patients with hepatocirrhosis.
Cheng
Mu-Hua
MH
Third Hospital Affiliated Sun Yat-sen University, Guangzhou 510630, China. marka@21cn.com
Pan
Zhi-Heng
ZH
Rao
Guo-Hui
GH
Xu
Jie-Hua
JH
Zhang
Feng
F
Chen
Wei-Zhen
WZ
Mo
Cong-Jian
CJ
D000328:Adult; D001663:Bilirubin / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005916:Globulins / Q000378:metabolism; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000188:drug therapy / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D000637:Transaminases / Q000097:blood
C521634:Dahuang Zhechong pill; D004365:Drugs, Chinese Herbal; D005916:Globulins; D000637:Transaminases; D001663:Bilirubin