Crucial role of interleukin-4 in the survival of colon cancer stem cells.
Colon tumors may be maintained by a rare fraction of cancer stem-like cells (CSC) that express the cell surface marker CD133. Self-renewing CSCs exhibit relatively greater resistance to clinical cytotoxic therapies and recent work suggests that this resistance may be mediated in part by an autocrine response to the immune cytokine interleukin 4 (IL-4). Blocking IL-4 signaling can sensitize CSCs to apoptotic stimuli and increase the in vivo efficacy of cytotoxic therapy. These findings suggest that inhibitors of IL-4 signaling may offer a new therapeutic tool in colon carcinoma.
Francipane
Maria Giovanna
MG
Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, Palermo, Italy.
Alea
Mileidys Perez
MP
Lombardo
Ylenia
Y
Todaro
Matilde
M
Medema
J P
JP
Stassi
Giorgio
G
D002470:Cell Survival / Q000502:physiology*; D003110:Colonic Neoplasms / Q000473:pathology*; D006801:Humans; D015847:Interleukin-4 / Q000502:physiology*; D014411:Neoplastic Stem Cells / Q000473:pathology*
D015847:Interleukin-4