[Influence of Tinglizi on collagen volume fraction and perivascular collagen area in left ventricle tissue of cardiac hypertrophy induced by abdominal aortic banding in rats].
OBJECTIVE
To evaluate the influence of Tinglizi on collagen volume fraction (CVF) and perivascular collagen volume area (PVCA ) in left ventricle tissue of cardiac hypertrophy induced by abdominal aortic banding in rats.


METHODS
Ventricular remodeling was induced by abdominal aortic banding (AAB) in rats. After 30 day treatment, the systolic blood pressure (SBP), diastolic blood pressure (DBP); heart rate (HR) were measured. The histological assay consisted of the HE stain for determining the myo-cardium cell cross section and collagen stain (Van Gieson' method) for determining collagen content, including collagen volume fracton (CVF) and perivascular collagen volume area (PVCA).


RESULTS
The experimental data demonstrated that Tinglizi decreased SBP, DBP, HR and could significantly reduce the total collagen content (CVF, PVCA) and lessen the myocardium cell cross section (P < 0.05).


CONCLUSIONS
Tinglizi may decrease the total collagen content of ventricle and attenuate the ventricular remodeling induced by abdominal aortic banding.
Deptartment of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Juan
J
Guo
Chang-Xun
CX
Chen
Wei-Liang
WL
Gu
Jun
J
Du
Yun-Hui
YH
Shen
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D020257:Ventricular Remodeling / Q000187:drug effects
D004365:Drugs, Chinese Herbal