[Effect of resveratrol on chronic obstructive pulmonary disease in rats and its mechanism].
The purpose of this study is to establish COPD animal model by intra-tracheal instillation of bleomycin (BLM) once and exposure to cigarette smoke for continuous 27 d, and to observe the effects of the inhalation on the model. At the 29th day, blood samples were taken from cervical artery for blood-gas analysis and parameters of lung function were recorded. Bronchoalveolar lavage fluid (BALF) was collected to measure intercellular adhesion molecule-1 (ICAM-1) concentration. The results showed that atomization inhaled resveratrol could alleviate rat COPD lung injury accompanied by amelioration of pathological changes, increase the ratio of forced expiratory volume in 0.3 s (FEV0.3) and forced vital capacity (FVC), and decrease the ICAM-1 level in BALF. The ultimate reduction of inflammatory factors was involved, at least in part, in the mechanism of resveratrol effects.
Center of New Drug Research and Development, Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, China.
Min
M
Zhou
Jian-Lin
JL
He
Shu-Qin
SQ
Yu
Rui-Fang
RF
Zhu
Jing
J
Lu
Fu-Yun
FY
Ding
Guang-Lin
GL
Xu
D000818:Animals; D001761:Bleomycin; D001784:Blood Gas Analysis; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D004195:Disease Models, Animal; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008168:Lung / Q000473:pathology*; D008170:Lung Compliance / Q000187:drug effects; D008297:Male; D008450:Maximal Midexpiratory Flow Rate / Q000187:drug effects; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D012907:Smoking; D013267:Stilbenes / Q000494:pharmacology*
D013267:Stilbenes; D001761:Bleomycin; D018799:Intercellular Adhesion Molecule-1; D000077185:Resveratrol