Isoflavones and rotenoids from the leaves of Millettia brandisiana.
A new isoflavone, 4'-gamma,gamma-dimethylallyloxy-5,7,2',5'-tetramethoxyisoflavone, brandisianin A (1), was isolated from the leaves of Millettia brandisiana, along with one synthetically known isoflavone, 7,4'-di-O-prenylgenistein (2) and twelve known compounds. The structures were elucidated on the basis of extensive spectroscopic analysis. Two isolated compounds were tested for anti-inflammatory activity; 12a-hydroxy-alpha-toxicarol (11) showed significant anti-inflammatory activity.
Department of Chemistry, Faculty of Science, Silpakorn University, Nakorn Pathom, Thailand. orasa@su.ac.th
Orasa
O
Pancharoen
Anan
A
Athipornchai
Ampai
A
Panthong
Walter Charles
WC
Taylor
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification; D007202:Indicators and Reagents; D007529:Isoflavones / Q000737:chemistry* / Q000302:isolation & purification; D008297:Male; D033641:Millettia / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012402:Rotenone / Q000031:analogs & derivatives / Q000737:chemistry* / Q000302:isolation & purification; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D007529:Isoflavones; D012402:Rotenone