Small arterial elasticity predicts the extent of coronary artery disease: Relationship with serum uric acid.
BACKGROUND
Arterial elasticity has been previously linked to atherosclerotic vascular disease states. Serum uric acid level has been recently associated with increased arterial stiffness, but to what extent serum uric acid reflects angiographic coronary artery status and vessel compliance remains to be established. In this study we aimed to evaluate the association of arterial elasticity indexes, serum uric acid and the presence and extent of angiographic coronary artery disease (CAD) in patients with chronic stable angina.


METHODS
One hundred and eight consecutive patients attending for elective coronary angiography were investigated. The severity of CAD was expressed using the Gensini score. Quantitative analysis of the arterial elasticity was performed by applanation tonometry. Serum uric acid was measured in all participants. Stepwise multiple linear regression analysis was used to identify the independent correlates of the Gensini score.


RESULTS
After adjustment for age, gender, common cardiac risk factors and cardiovascular drugs, small artery elasticity index (SAEI) (p<0.001) and serum uric acid (p<0.001) were independently correlated with the severity of CAD. Stepwise multiple linear regression analysis was also used to identify independent correlates of the SAEI. Serum uric acid emerged as the only independent correlate of SAEI (p<0.001).


CONCLUSIONS
SAEI independently reflects the extent of CAD in patients with chronic stable angina. This relationship is chiefly mediated by serum uric acid. Our data add to the growing evidence that serum uric acid may be a marker of arterial stiffness and atherosclerotic burden.
Department of Cardiology, Uludag University School of Medicine, Bursa, Turkey.
Murat
M
Fazlioğlu
Tunay
T
Sentürk
Ethem
E
Kumbay
Aysel Aydin
AA
Kaderli
Yusuf
Y
Yilmaz
Bülent
B
Ozdemir
Ibrahim
I
Baran
Ali
A
Aydinlar
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D004548:Elasticity; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008365:Manometry; D008875:Middle Aged; D012307:Risk Factors; D014527:Uric Acid / Q000032:analysis / Q000097:blood*
D014527:Uric Acid