Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers.
In this review, we highlight the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers. The synthesis of this type of MSN materials is described along with the current methods for controlling the structural properties and chemical functionalization for biotechnological and biomedical applications. We summarized the advantages of using MSN for several drug delivery applications. The recent investigations of the biocompatibility of MSN in vitro are discussed. We also describe the exciting progress on using MSN to penetrate various cell membranes in animal and plant cells. The novel concept of gatekeeping is introduced and applied to the design of a variety of stimuli-responsive nanodevices. We envision that these MSN-based systems have a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents.
Department of Chemistry and U.S. Department of Energy Ames Laboratory, 0755 Gilman Hall, Iowa State University, Ames, Iowa 50011-3111, USA.
Igor I
II
Slowing
Juan L
JL
Vivero-Escoto
Chia-Wen
CW
Wu
Victor S-Y
VS
Lin
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D014162:Transfection / Q000379:methods
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012822:Silicon Dioxide