Fatal neonatal myocarditis caused by a recombinant human enterovirus-B variant.
We report a case of fatal myocarditis in a newborn infant who was infected with a human enterovirus detected by throat culture and RT-PCR for viral RNA in plasma. Whole genome sequence analysis revealed the virus to be a genomic chimera that likely arose from recombination between coxsackievirus B3 and two recently identified enteroviruses, EV 86 and EV97.
Krogstad
Paul
P
Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. pkrogstad@mednet.ucla.edu
Hammon
Rebecca
R
Halnon
Nancy
N
Whitton
J Lindsay
JL
D029822:Enterovirus B, Human / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000175:diagnosis*; D017809:Fatal Outcome; D016679:Genome, Viral; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008969:Molecular Sequence Data; D009205:Myocarditis / Q000821:virology*; D010614:Pharynx / Q000821:virology; D010949:Plasma / Q000821:virology; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D014776:Virus Cultivation
D012367:RNA, Viral