Fungicidal activity of truncated analogues of dihydrosphingosine.
The minimal fungicidal concentration (MFC) of dihydrosphingosine (DHS), phytosphingosine (PHS), and five short-chain DHS derivatives was determined for Candida albicans and Candida glabrata. In this respect, a C15- and a C17-homologue of DHS showed a 2- to 10-fold decreased MFC as compared to native DHS (i.e. C18-DHS). DHS derivatives that were active, that is, comprising 12, 15, 17, or 18 carbon atoms, induced accumulation of reactive oxygen species (ROS) in C. albicans.
Centre of Microbial and Plant Genetics (CMPG), Katholieke Universiteit Leuven, Kasteelpark Arenberg 20, 3001 Heverlee, Belgium.
Karin
K
Thevissen
Ulrik
U
Hillaert
Els M K
EM
Meert
Kuen K
KK
Chow
Bruno P A
BP
Cammue
Serge
S
Van Calenbergh
Isabelle E J A
IE
François
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002176:Candida albicans / Q000378:metabolism; D041221:Candida glabrata / Q000378:metabolism; D002244:Carbon / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D006801:Humans; D008956:Models, Chemical; D008968:Molecular Conformation; D010100:Oxygen / Q000737:chemistry; D017382:Reactive Oxygen Species; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
D000935:Antifungal Agents; D017382:Reactive Oxygen Species; D002244:Carbon; C012491:phytosphingosine; D013110:Sphingosine; C005682:safingol; D010100:Oxygen