The application of fast multiparametric protocol MRI-based thrombolysis with rt-PA hyperacute cerebral infarction.
OBJECTIVE
To investigate the value of fast multiparametric protocol magnetic resonance imaging (MRI)-based thrombolysis in hyperacute cerebral infarction.


METHODS
Seventy-seven patients with acute ischemic stroke were examined by multiparametric protocol MRI and among them, 12 patients with hyperacute cerebral infarction were treated by recombinant tissue plasminogen activator (rt-PA) and followed up periodically by MRI.


RESULTS
The 12 patients selected by FMPMRI to receive thrombolysis demonstrated clinical improvement, with 90 day modified Rankin scale scores (mRs) < or = 2 and life quality Barthel index (BI) of 80-100. The only complication involved one patient (8.3%) who developed an asymptomatic intracranial hemorrhage 3 weeks after receiving thrombolytics.


CONCLUSIONS
Multiparametric protocols have significant clinical potential for the treatment of hyperacute stroke patients who are candidates for receiving intravenous thrombolytic therapy. Our data suggest that patients suffering from hyperacute ischemic cerebral infarction that are strong candidates for intravenous thrombolytic therapy can be identified by multiparametric protocol MRI, especially to those whose time windows were undefined or beyond 3 hours after symptom onset.
Department of Neurology, People's Hospital of Pudong New Area, Shanghai, China.
Qingke
Q
Bai
Zhenguo
Z
Zhao
Yuehua
Y
Li
Haijing
H
Sui
Xiuhai
X
Xie
Yi
Y
Gong
Xiaohui
X
Zhao
Lianwen
L
Wang
Weiying
W
Xia
Jian
J
Shen
Lianjun
L
Lu
D000208:Acute Disease; D000368:Aged; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D002536:Cerebral Arteries / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D002544:Cerebral Infarction / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D002985:Clinical Protocols / Q000592:standards; D004632:Emergency Medical Services / Q000379:methods* / Q000592:standards; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome
D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator