A semi-automated system for concentration of rhenium-188 for radiopharmaceutical applications.
A semi-automated system has been designed and installed for the routine production of highly concentrated solutions of rhenium-188 perrhenate in saline which incorporates extensive radiation protection for the laboratory staff. This new system represents a simple, rapid, and effective computer controlled method using inexpensive disposable components. The flipper-valve settings and the radioactivity measured by use of collimated gamma dose rate probes are continuously monitored. If necessary, 2-3 tungsten-188/rhenium-188 generators can be eluted in a tandem arrangement. Eluate volumes (1.3-2 ml) of maximum specific radioactivity of 25 GBq/ml were routinely prepared.
Wunderlich
G
G
Department of Nuclear Medicine, University Hospital, Dresden, Germany. gerd.wunderlich@uniklinikum-dresden.de
Hartmann
H
H
Andreeff
M
M
Kotzerke
J
J
D004867:Equipment Design; D019544:Equipment Failure Analysis; D007553:Isotope Labeling / Q000295:instrumentation* / Q000379:methods; D011835:Radiation Protection / Q000295:instrumentation*; D011868:Radioisotopes / Q000737:chemistry / Q000302:isolation & purification; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000302:isolation & purification*; D012211:Rhenium / Q000737:chemistry* / Q000302:isolation & purification*; D012371:Robotics / Q000295:instrumentation*
D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012211:Rhenium