Mollamides B and C, Cyclic hexapeptides from the indonesian tunicate Didemnum molle.
Two new cyclic hexapeptides, mollamides B (1) and C (2), were isolated from the Indonesian tunicate Didemnum molle along with the known peptide keenamide A (3). The structures were established using 1D and 2D NMR experiments. The relative configuration of mollamide B at the thiazoline moiety was determined using molecular modeling coupled with NMR-derived restraints. Their absolute configuration was determined using Marfey's method. The new peptides have been evaluated for their antimicrobial, antimalarial, anticancer, anti-HIV-1, anti-Mtb, and anti-inflammatory activities. Keenamide A and mollamide B show cytotoxicity against several cancer cell lines.
Department of Pharmacognosy, The University of Mississippi, USA.
Marwa S
MS
Donia
Bin
B
Wang
Daniel C
DC
Dunbar
Prashant V
PV
Desai
Akshay
A
Patny
Mitchell
M
Avery
Mark T
MT
Hamann
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007214:Indonesia; D007893:Leishmania donovani / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D051381:Rats; D014561:Urochordata / Q000737:chemistry*
D000962:Antimalarials; D000970:Antineoplastic Agents; D052246:Cyclooxygenase 2 Inhibitors; D010456:Peptides, Cyclic; C100907:keenamide A; C530775:mollamide B; C530776:mollamide C