The effects of immunosuppression on regulatory CD4(+)CD25(+) T cells: impact on immunosuppression selection in transplantation.
During immune response and T-cell activation, both effector T cells and regulatory T(T(reg)) cells are activated and regulated simultaneously by both positive and negative pathways. CD4(+)CD25(+) T(reg) cells play a critical role in immune tolerance to self antigens as well as to allografts in some transplant settings. Effective immunosuppressive regimens significantly reduced the incidence of acute allograft rejection in patients following organ transplantation. However, the impact of immunosuppressive treatment on the potential induction of transplant tolerance has not been well determined. In this review we summarize the effects of immunosuppressive reagents on CD4(+)CD25(+) T(reg) cells in order to bring attention to this issue, which may affect the choice of immunosuppressive regimen in the clinical setting.
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Aqeel
A
Javeed
Yong
Y
Zhao
D006801:Humans; D007108:Immune Tolerance / Q000276:immunology / Q000502:physiology; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D008954:Models, Biological; D012107:Research Design; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000378:metabolism; D019172:Transplantation Conditioning / Q000379:methods*; D014181:Transplantation Immunology / Q000187:drug effects*
D007166:Immunosuppressive Agents; D053645:Interleukin-2 Receptor alpha Subunit