Emotional and learning behaviour in mice overexpressing heat shock protein 70.
The effects of inducible heat shock protein 70 (HSP70) on emotional and learning behaviour as well as hippocampal long-term potentiation was investigated in transgenic HSP70 overexpressing mice. In active two-way avoidance learning (shuttle box) as well as spatial 8-arm radial maze learning, the HSP70 overexpressing mice showed diminished learning performance. In several tests there was no indication of differences in anxiety behaviour between transgenic mice and wild-type mice. This suggests that impairment in learning behaviour is unrelated to the learning task and motivational aspects of behaviour. To investigate the neurophysiological correlate of learning, long-term potentiation experiments were performed. In transversal hippocampal slices, an enhanced amplitude of the population spike was found in HSP70 overexpressing mice. It was hypothesised that enhanced potentiation in conjunction with potentiation effects due to learning led to learning impairment.
Otto-von-Guericke University, Faculty of Medicine, Institute of Pharmacology and Toxicology, Leipziger Str. 44, 39120 Magdeburg, Germany.
Susanne
S
Ammon-Treiber
Gisela
G
Grecksch
Charalampos
C
Angelidis
Patra
P
Vezyraki
Volker
V
Höllt
Axel
A
Becker
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D003214:Conditioning, Classical / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D005239:Fear / Q000502:physiology; D015870:Gene Expression / Q000235:genetics*; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006624:Hippocampus / Q000033:anatomy & histology / Q000502:physiology*; D017774:Long-Term Potentiation / Q000235:genetics*; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D009042:Motivation; D009043:Motor Activity / Q000235:genetics; D009048:Motor Skills / Q000502:physiology*; D004856:Postural Balance / Q000502:physiology; D011930:Reaction Time / Q000235:genetics; D013239:Stereotyped Behavior / Q000502:physiology*
D018840:HSP70 Heat-Shock Proteins