Searching for disease susceptibility variants in structured populations.
Data for genome-wide association studies are being collected for a myriad of phenotypes. Many of these studies do not include control samples selected to reflect ancestry similar to the case samples. At the same time "control databases" are becoming available to be utilized as a common resource. These data are often genotyped using a large-scale SNP array. Human populations exhibit complex structure that can lead to spurious associations if not properly handled. How to couple case and control databases effectively is a pressing question. We review available methods for modeling genetic ancestry based on the information gleaned from the SNP array. Methods for selecting control samples with genetic ancestry similar to the case samples are described.
Department of Statistics, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213-3890, USA. roeder@stat.cmu.edu
Kathryn
K
Roeder
Diana
D
Luca
D016022:Case-Control Studies; D030541:Databases, Genetic; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D025341:Principal Component Analysis