[Inhibitory effects of Sanleng pellet on angiogenesis of endometriosis in rats].
OBJECTIVE
To investigate the effect of Sanleng pellet on angiogenesis of endometriosis in SD rats.


METHODS
The rat model of endometriosis were treated with Sanleng pellet. Observe microvessels density by immunohistochemical test as well as the expression of vascular endothelial growth factor and tumor necrosis factor-alpha in ectopic endometriotic tissue by immunohistochemical test and RT-PCR.


RESULTS
Sanleng pellet can reduce MVD, and inhibit the level of protein and mRNA of vascular endothelial growth factor and TNF-alpha in ectopic endometriotic tissue.


CONCLUSIONS
Sanleng pellet can reduce the degree of angiogenesis in the endometriosis rats, and its mechanism might be associated with inhibiting the expression of vascular endothelial growth factor and TNF-alpha in the heterotopic tissue.
School of Pharmaceutical and Chinese Traditional Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Yi
Y
Chen
Xiao-Yu
XY
Xu
Lan
L
Ye
Hui-Fengi
HF
Zhu
Hong
H
Chen
Gong
G
Chen
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004715:Endometriosis / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D007150:Immunohistochemistry; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A