Cooperative catalysis with chiral Brønsted acid-Rh2(OAc)4: highly enantioselective three-component reactions of diazo compounds with alcohols and imines.
An asymmetric three-component reaction of diazo compounds and alcohols with imines catalyzed cooperatively by a rhodium complex and a chiral Brønsted acid provides a general and efficient entry to beta-amino-alpha-hydroxyl acid derivatives in high yields with excellent stereoselectivities.
Department of Chemistry, East China Normal University, Shanghai 200062, China. whu@chem.ecnu.edu.cn
Wenhao
W
Hu
Xinfang
X
Xu
Jing
J
Zhou
Wei-Jun
WJ
Liu
Haoxi
H
Huang
Juan
J
Hu
Liping
L
Yang
Liu-Zhu
LZ
Gong