Management of skull base defect with bFGF after extensive skull base surgery - two case reports.
The basic fibroblast growth factor (bFGF) is one of the most powerful growth factors to promote wound healing. In this paper we describe two cases of skull base tumor requiring extensive skull base reconstruction, in which the application of bFGF was effective in the management and prevention of CSF leaks. The role and safeness of bFGF for skull base reconstruction are discussed.
Hashimoto
N
N
Department of Neurosurgery, Osaka University Graduate School of Medicine, Yamada-oka, Suita, Japan.
Taniguchi
M
M
Kato
A
A
Fujimoto
Y
Y
Yoshimine
T
T
D000287:Administration, Topical; D000368:Aged; D002559:Cerebrospinal Fluid Rhinorrhea / Q000175:diagnosis / Q000601:surgery*; D002817:Chordoma / Q000601:surgery*; D003388:Cranial Fossa, Posterior / Q000601:surgery*; D004388:Dura Mater; D018304:Esthesioneuroblastoma, Olfactory / Q000175:diagnosis / Q000601:surgery*; D005346:Fibroblast Growth Factors / Q000008:administration & dosage*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000601:surgery; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000601:surgery*; D010446:Peptide Fragments / Q000008:administration & dosage*; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000175:diagnosis / Q000601:surgery*; D019736:Prostheses and Implants; D012086:Reoperation; D019291:Skull Base / Q000601:surgery; D019292:Skull Base Neoplasms / Q000175:diagnosis / Q000601:surgery*; D013101:Sphenoid Sinus / Q000601:surgery*; D013524:Surgical Flaps; D014945:Wound Healing / Q000187:drug effects
D010446:Peptide Fragments; C114444:trafermin; D005346:Fibroblast Growth Factors; D011138:Polytetrafluoroethylene