Dendrimers and DNA: combinations of two special topologies for nanomaterials and biology.
Interactions between two precisely defined three-dimensional architectures (DNA and dendrimers) are described. Highly synergetic effects occur, as illustrated in two cases: dendrimers can be used as three-dimensional linkers for oligonucleotides, affording highly sensitive microarrays (biochips), and positively charged dendrimers strongly interact with DNA, allowing penetration inside cells (genetic transfection).
Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, Toulouse Cedex 4, France. caminade@lcc-toulouse.fr
Anne-Marie
AM
Caminade
Cédric-Olivier
CO
Turrin
Jean-Pierre
JP
Majoral
D000818:Animals; D001693:Biological Transport, Active; D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D050091:Dendrimers / Q000737:chemistry* / Q000378:metabolism; D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D020411:Oligonucleotide Array Sequence Analysis; D009841:Oligonucleotides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D050091:Dendrimers; D009841:Oligonucleotides; D004247:DNA