Antimicrobial resistance of uncomplicated urinary tract infections in northern Utah.
OBJECTIVE
To evaluate antimicrobial resistance in uropathogenic bacteria in northern Utah.


METHODS
One hundred twenty bacterial isolates from community-acquired UTI in the northern Utah area (Davis and Weber Counties) were tested. Samples were taken from otherwise healthy women, ages 18 to 50. Antimicrobial susceptibility testing for sulfamethoxazole/trimethoprim (SXT/TMP), ciprofloxacin, and nitrofurantoin comprised the process.


METHODS
The Clinical Laboratory Science Department at Weber State University, with samples coming from clinics in the northern Utah area (Davis and Weber Counties).


METHODS
Urine samples were taken from otherwise healthy women, ages 18 to 50, who suffered from uncomplicated urinary tract infections.


METHODS
Antimicrobial resistance was measured using antimicrobial susceptibility testing and shown with other national resistance rates.


RESULTS
Of bacterial isolates, 21.3% were resistant to SXT/TMP, 14.4% were resistant to ciprofloxacin, and 13.9% were resistant to nitrofurantoin. The resistance rates for ciprofloxacin and nitrofurantoin were acceptable for empirical UTI treatment (< 20% resistance), but local bacterial populations were found to demonstrate an increase in resistance to these two drugs as compared to previously observed national data. SXT/TMP resistance was above the recommended resistance threshold of 20% for effective empirical treatment, as advised by the IDSA.


CONCLUSIONS
Results suggest that uncomplicated community-acquired UTI be treated with nitrofurantoin. Other recommendations include continued monitoring of local uropathogenic antimicrobial resistance.
Mayo Clinic, Rochester, MN, USA.
Michael
M
McQuilkin
Alexander
A
Lund
Wyatt
W
Palmer
D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D014589:Utah / Q000453:epidemiology
D000890:Anti-Infective Agents