A chiral thioureido acid as an effective additive for enantioselective organocatalytic Michael additions of nitroolefins.
A novel and effective organocatalytic system consisting of pyrrolidinyl-thioimidazole and a chiral thioureido acid efficiently catalyzed the asymmetric Michael addition reactions of ketones to nitroolefins to afford the adducts with high diastereoselectivities (up to 99 : 1) and excellent enantioselectivities (up to 99% ee).
Xu
Dan-Qian
DQ
State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou, 310014, China. greenchem@zjut.edu.cn
Yue
Hua-Dong
HD
Luo
Shu-Ping
SP
Xia
Ai-Bao
AB
Zhang
Shuai
S
Xu
Zhen-Yuan
ZY