Elevated plasma total homocysteine in preeclampsia.
OBJECTIVE
To investigate the possible association between hyperhomocysteinemia and preeclampsia.


METHODS
A case-control study was carried out in the Departments of Obstetrics and Gynecology of the Ghaem Hospitals in Mashhad University of Medical Sciences, Mashhad, Iran from May 2004 to August 2006 and included 75 preeclamptic patients, 37 women with mild preeclampsia, and 38 women with severe preeclampsia, in addition we included 40 controls without pregnancy complications. Plasma total homocysteine was determined in all subjects by enzyme linked immunosorbent assay.


RESULTS
The 3 groups were similar in age and body. Patients with severe preeclampsia had significantly higher mean plasma levels (13.8+/-7 mg/l) than normal pregnant women (8.8+/-2.8 mg/l) and mild pre-eclamptic women (10.4+/-2.3 mg/l) (p<0.05).


CONCLUSIONS
Women who developed severe preeclampsia have higher plasma homocysteine levels than women who remain normotensive throughout pregnancy.
Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. HasanzademofradM@mums.ac.ir
Malihe
M
Hasanzadeh
Hossein
H
Ayatollahi
Mahdi
M
Farzadnia
Sedigeh
S
Ayati
Mehdi K
MK
Khoob
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
D006710:Homocysteine