High failure rates of melarsoprol for sleeping sickness, Democratic Republic of Congo.
A retrospective chart review of 4,925 human African trypanosomiasis patients treated with melarsoprol in 2001-2003 in Equateur Nord Province of the Democratic Republic of Congo showed a treatment failure rate of 19.5%. This rate increased over the 3 years. Relapse rates were highest in the central part of the province.
Robays
Jo
J
Institute of Tropical Medicine, Antwerp, Belgium. jrobays@itg.be
Nyamowala
Gaspard
G
Sese
Claude
C
Betu Ku Mesu Kande
Victor
V
Lutumba
Pascal
P
Van der Veken
Wim
W
Boelaert
Marleen
M
D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D015023:Democratic Republic of the Congo / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008549:Melarsoprol / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D012008:Recurrence; D017211:Treatment Failure; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D014353:Trypanosomiasis, African / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control
D014344:Trypanocidal Agents; D008549:Melarsoprol