"Self-activating" chemical nuclease: ferrocenyl cyclen Cu(II) complexes act as efficient DNA cleavage reagents in the absence of reductant.
The interactions of cyclen Cu(II) complexes functionalized by ferrocenyl group with plasmid DNA indicated that these complexes have high cleavage efficiency via an oxidative mechanism in the absence of any reductant or oxidant.
Li
Kun
K
Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, No. 29, Wangjiang Road, Chengdu, Sichuan 610064, PR China.
Zhou
Li-Hong
LH
Zhang
Ji
J
Chen
Shan-Yong
SY
Zhang
Zhong-Wei
ZW
Zhang
Jing-Jing
JJ
Lin
Hong-Hui
HH
Yu
Xiao-Qi
XQ
D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects*; D005296:Ferrous Compounds / Q000737:chemistry*; D007202:Indicators and Reagents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008024:Ligands; D000075163:Metallocenes; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D019163:Reducing Agents / Q000378:metabolism
D005296:Ferrous Compounds; D007202:Indicators and Reagents; D008024:Ligands; D000075163:Metallocenes; D009942:Organometallic Compounds; D019163:Reducing Agents; D003300:Copper; D004247:DNA; C004998:ferrocene