Sixteen-row multislice computed tomography angiography in the diagnosis and characterization of intracranial aneurysms: comparison with conventional angiography and intraoperative findings.
OBJECTIVE
The goal of this study was to prospectively compare the effectiveness of 16-slice computed tomography (CT) angiography with that of conventional digital subtraction (DS) angiography and the surgical findings used to detect and characterize intracranial aneurysms.


METHODS
Two hundred forty-four consecutive patients underwent both CT angiography and DS angiography no more than 3 days apart. Computed tomography angiography was performed with a 16-row multislice CT scanner in which a collimation of 0.75 mm was used. Two observers independently reviewed the CT images, and 1 of the 3 attending neuroradiologists reviewed the DS angiograms. They determined the presence, location, quantitation, and characterization of the intracranial aneurysms. Statistical results were calculated independently for the image interpretation performed by the 2 CT scan readers and the DS angiogram reader by using the combination of DS angiography or intraoperative findings or both as a reference standard.


RESULTS
One hundred thirty-six patients harboring 153 intracranial aneurysms were included in this series. There was no statistically significant difference in sensitivity between 16-slice CT angiography and conventional DS angiography (p > 0.05). The sensitivities of 16-slice CT angiography for aneurysms < 5 mm, 5-10 mm, and > 10 mm were 94.8, 100, and 100%, respectively, on a per-aneurysm basis. The overall sensitivity and specificity of CT angiography for aneurysms were 98.0 and 99.1%, respectively. Sixteen-slice CT angiograms were clearer and more accurate in depicting the relationship of aneurysms to bone structures and adjacent branch vessels.


CONCLUSIONS
Computed tomography angiography using a 16-slice scanner is an accurate tool for detecting and characterizing intracranial aneurysms, including small aneurysms. Noninvasive 16-slice CT angiography will become a viable replacement for conventional DS angiography in the diagnosis and characterization of aneurysms.
Department of Radiology and Neurosurgery, The Third Affiliated Hospital of Suzhou University, Changzhou, China.
Wenhua
W
Chen
Yilin
Y
Yang
Wei
W
Xing
Jianguo
J
Qiu
Ya
Y
Peng
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015901:Angiography, Digital Subtraction; D002533:Cerebral Angiography / Q000379:methods*; D002648:Child; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D013997:Time Factors; D014057:Tomography, X-Ray Computed