Intraoperative platelet and plasma improves survival in patients operated for a rAAA: a follow-up evaluation.
OBJECTIVE
Continued haemorrhage remains a significant contributor to mortality in massively transfused patients. We found that early administration of platelets and plasma reduced mortality from 54% to 36% in rAAA patients. The aim of the present evaluation was to evaluate whether reduced mortality in rAAA patients related to a pro-active transfusion therapy is maintained.


METHODS
Single-centre observational study.


METHODS
Mortality of patients operated for rAAA 2006-07 was compared to that of patients operated 2004-05 (intervention group; n=50) and 2002-04 (control group, n=82).


RESULTS
64 consecutive patients with rAAA received, similar to the intervention group, more platelets (5 and 4 vs. 0 units, P<0.05) and plasma (12 and 11 vs. 7 units, P<0.05) intraoperatively and had a higher platelet count (158 and 155 vs. 69 x 10(9)/L, P<0.0001) upon arrival at the intensive care unit and the 30-day mortality remained reduced (24% and 36% vs. 56%, P<0.01 and P=0.02, respectively) as compared to the control patients.


CONCLUSIONS
Early administration of platelets and plasma, together with red blood cells maintained reduced mortality in patients operated for rAAAin a 18 month period.
Department of Clinical Immunology, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Denmark. per.johansson@rh.regionh.dk
P I
PI
Johansson
F
F
Swiatek
L
L
Jørgensen
L P
LP
Jensen
N H
NH
Secher
D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000401:mortality / Q000601:surgery*; D016063:Blood Loss, Surgical; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D010949:Plasma; D017713:Platelet Transfusion; D011182:Postoperative Care; D015996:Survival Rate