Gold(I)-catalyzed cycloisomerization of 1,7- and 1,8-enynes: application to the synthesis of a new allocolchicinoid.
Gold(I)-catalyzed cycloisomerization of 1,7- and 1,8-enyne propargylic acetates afforded cyclopropyl derivatives containing seven- and eight-membered rings, respectively. This reaction was used for the synthesis of a new allocolchicinoid having a cyclopropane ring fused to the B seven-membered ring at the C6-C7 positions.
Unité de Chimie Biologique, INRA, F-78026 Versailles, France.
François-Didier
FD
Boyer
Xavier
X
Le Goff
Issam
I
Hanna
D002384:Catalysis; D003078:Colchicine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D006046:Gold / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure
D006046:Gold; D003078:Colchicine