[Effect of sevoflurane on spontaneous brain bioelectrical activity in neurosurgical patients].
The present study was undertaken to evaluate the effects of sevoflurane on spontaneous brain bioelectrical activity in neurosurgical patients. Forty patients treated at the Research Institute of Neurosurgery underwent a neurophysiological examination. No epileptic syndrome was revealed in the clinical picture in 10 patients (a control group), the remaining 30 patients had a history of varying epileptic seizures of different degrees and frequency. Sevoflurane causes a relative acceleration of epileptiform activity synchronization, as evidenced by EEG, which is not a contraindication to the use of this drug in patients with cerebral organic lesion of various genesis with a history of epileptic syndrome and fails to induce clinically significant EEG epileptiform manifestations in patients without epilepsy. In patients with cerebrovascular abnormalities (arteriovenous malformation, cavernous angiomas) who have a history of paroxysmal conditions, inhalational sevoflurane anesthesia can be performed in combination with anticonvulsants (benzodiazepines) during an operation.
D A
DA
Moshchev
O B
OB
Sazonova
A A
AA
Ogurtsova
A Iu
AIu
Lubnin
D000293:Adolescent; D000328:Adult; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology / Q000601:surgery; D001932:Brain Neoplasms / Q000150:complications / Q000601:surgery*; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D019635:Neurosurgical Procedures; D011292:Premedication / Q000379:methods; D012640:Seizures / Q000209:etiology* / Q000503:physiopathology; D000077149:Sevoflurane; D016896:Treatment Outcome
D018685:Anesthetics, Inhalation; D000927:Anticonvulsants; D008738:Methyl Ethers; D000077149:Sevoflurane