Production of teicoplanin from Actinoplanes teichomyceticus ID9303 by adding proline.
We evaluated the influence of amino acids in improving teicoplanin productivity. Arginine, lysine, and proline were selected for better productivity among 20 amino acids in Erlenmeyer flasks. Proline was finally chosen as the additive for maximum teicoplanin productivity in a 5-liter fermenter. We obtained the highest teicoplanin productivity, 3.12 g/l, on the eighth d in a 75-liter pilot fermenter.
Research Laboratories, Ildong Pharmaceutical, Yongin 449-910, Korea.
Jung-Min
JM
Song
Joon-Tae
JT
Park
Hong-Sub
HS
Lee
Jae-Hoon
JH
Kang
Dae-Jung
DJ
Kang
D000192:Actinomycetales / Q000187:drug effects / Q000378:metabolism*; D011392:Proline / Q000378:metabolism* / Q000494:pharmacology; D017334:Teicoplanin / Q000096:biosynthesis*
D017334:Teicoplanin; D011392:Proline