Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC.
Single molecule fluorescence spectroscopy has been employed to resolve the conformational heterogeneity, hybridization kinetics and study mutational effects on the c-MYC promoter G-quadruplex.
Shirude
Pravin S
PS
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.
Ying
Liming
L
Balasubramanian
Shankar
S
D004247:DNA / Q000737:chemistry* / Q000235:genetics*; D054856:G-Quadruplexes; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc / Q000737:chemistry* / Q000235:genetics*
D016271:Proto-Oncogene Proteins c-myc; D004247:DNA