Lipophilicity of thiobarbiturates determined by TLC.
Lipophilicty of 29 thiobarbituric acid derivatives were assessed by reversed-phase thin-layer chromatography using methanol: water mixtures as a mobile phase. A linear relationship was found between RM values and methanol concentrations in the mobile phase. The retention parameter, RM0, was related to theoretical partition coefficients calculated by means of different theoretical procedures (AlogPs, IAlogP, miLogP, logPKowwin, xlogP).
Kepczyńska
Elzbieta
E
Department of Organic Chemistry, Medical College of Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland.
Obłoza
Ewa
E
Stasiewicz-Urban
Anna
A
Bojarski
Jacek
J
Pyka
Alina
A
D002855:Chromatography, Thin Layer / Q000379:methods*; D057927:Hydrophobic and Hydrophilic Interactions; D000432:Methanol / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D012995:Solubility; D013858:Thiobarbiturates / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D013858:Thiobarbiturates; D014867:Water; D000432:Methanol