Deferoxamine induces endoplasmic reticulum stress in PC12 cells.
Deferoxamine (DFA, N'-[5-(acetyl-hydroxy-amino)-pentyl]-N-[5-[3-(5-aminopentyl-hydroxy-carbamoyl) propanoylamino]pentyl]-N-hydroxy-butane diamide) is a chelating agent used to remove excess iron from the body and to reduce organ and tissue damage. DFA enhances both iron regulatory protein 1 (IRP1) expression and its endoplasmic reticulum (ER) membrane-binding activity, as occurs in hypoxia, an ER stress, in cultured cells. Here, we show that DFA promotes ER stress via an ER signal pathway.
Department of Surgery, College of Medicine, Konkuk University, Seoul 143-729, Korea.
Young-Bum
YB
Yoo
Kyeong Ryong
KR
Lee
Seung-Whan
SW
Kim
Kisang
K
Kwon
Tae-Won
TW
Goo
O-Yu
OY
Kwon
D000818:Animals; D002460:Cell Line; D017931:DNA Primers; D003676:Deferoxamine / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000502:physiology*; D016716:PC12 Cells / Q000187:drug effects; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D017931:DNA Primers; D003676:Deferoxamine