[Effects of total rhizoma panacis japonica saponins (tRPJS) on nitric oxide synthase in hippocampus region following rat ischemic cerebral injury].
OBJECTIVE
To observe the protective effects of total rhizoma panacis japonica saponins (tRPJS) on cerebral ischemia injury in rats.


METHODS
The rat model of local cerebral ischemia by using thread method, produced the chronic forebrain ischemic by using the permanent occlusion of bilateral common carotid arteries in rats. Investigating the influence of tRPJS on the activity of NOS and iNOS in hippocampus region.


RESULTS
tRPJS obviously reduced the contents of NOS and iNOS in hippocampus region of local cerebral ischemia rat tRPJS inhibited the increase of iNOS content caused by pemanent ligation of bilateral carotid artery.


CONCLUSIONS
tRPJS has significantly protective effects by virtue of decreasing iNOS.
College of Traditional Chinese Medicine, Capital University of Medical Science, Beijing 100069, China. zhaohui8957@sina.com
Hui
H
Zhao
Qiu-Xia
QX
Zhang
Yang
Y
Mu
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D012503:Saponins; D019001:Nitric Oxide Synthase