Evaluation of cross-protection by immunization with an experimental trivalent companion animal periodontitis vaccine in the mouse periodontitis model.
Companion animal periodontal disease is one of the most prevalent diseases seen by veterinarians. The goal of this study was to evaluate the vaccine performance of a trivalent canine periodontitis vaccine in the mouse oral challenge model of periodontitis. Mice vaccinated subcutaneously with an inactivated, whole-cell vaccine preparation of Porphyromonas denticanis, Porphyromonas gulae, and Porphyromonas salivosa displayed significantly reduced alveolar bone loss in response to heterologous and cross-species challenges as compared to sham vaccinated animals. Based on the results of these studies, a periodontitis vaccine may be a useful tool in preventing the initiation and progression of periodontitis caused by the most commonly isolated pigmenting anaerobic bacteria in animals.
Hardham
John
J
Pfizer Inc., Veterinary Medicine Research and Development, Kalamazoo, MI 49001, USA. john.m.hardham@pfizer.com
Sfintescu
Cornelia
C
Evans
Richard T
RT
D000818:Animals; D000829:Animals, Domestic; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D001439:Bacteroides / Q000276:immunology*; D004195:Disease Models, Animal; D007279:Injections, Subcutaneous / Q000662:veterinary; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010518:Periodontitis / Q000517:prevention & control / Q000662:veterinary*; D017861:Porphyromonas / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000008:administration & dosage
D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated