Neuro-psychiatric therapy during chronic subthalamic stimulation in Parkinson's disease.
BACKGROUND
Neuro-psychiatric (NP) disturbances are highly prevalent in patients with Parkinson's disease (PD) and contribute to worsen quality of life. Deep brain stimulation of the subthalamic nucleus (STN-DBS) is commonly utilized as surgical treatment for advanced PD with motor complications. The effectiveness of the procedure on motor symptoms is well established whereas the effects of STN-DBS on NP symptoms are less clear. The aim of our study was to analyze the postoperative pharmacological therapy for NP symptoms in a group of STN-DBS treated PD patients. Such therapy provides indirect information about the evolution of underlying NP disturbances during the follow-up in this group of PD patients.


METHODS
NP therapy (benzodiazepines, antidepressants, antipsychotics) was assessed in 48 consecutive PD patients treated by STN-DBS, preoperatively and postoperatively after 4 months, 1 year and 3 years. Motor symptoms were evaluated by the Unified PD Rating Scale (UPDRS) and levodopa equivalence daily dose (LEDD) was calculated. Cognitive, mood and anxiety assessments were performed with appropriate rating scales.


RESULTS
The number of patients treated with antidepressant drugs gradually increased during the follow-up. The use of antipsychotic drugs was stable until 1 year, with a subsequent increase at 3 years. Benzodiazepines were given to fewer patients immediately after surgery.


CONCLUSIONS
Pharmacological treatment supplies further information about NP symptoms in the follow-up of PD patients undergoing STN stimulation.
Department of Neuroscience, University of Turin, via Cherasco 15, 10126 Turin, Italy. mzibetti@molinette.piemonte.it
M
M
Zibetti
M
M
Pesare
A
A
Cinquepalmi
M
M
Rosso
L
L
Castelli
L
L
Rizzi
B
B
Bergamasco
M
M
Lanotte
L
L
Lopiano
D000368:Aged; D001526:Behavioral Symptoms / Q000188:drug therapy* / Q000209:etiology*; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy* / Q000209:etiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000628:therapy; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D020531:Subthalamic Nucleus / Q000502:physiology / Q000503:physiopathology; D014149:Tranquilizing Agents / Q000627:therapeutic use*
D014149:Tranquilizing Agents