A putative role of the Amyloid Precursor Protein Intracellular Domain (AICD) in transcription.
Amyloid Precursor Protein (APP) Intracellular Domain (AICD) is the product of APP processing realized by alpha- or beta-secretases and gamma-secretase. It was shown that AICD is able to interact with several proteins which regulate its stability and cellular localization. The Fe65 adaptor protein translocates AICD into nucleus where the APP-Fe65-Tip60 ternary complex may activate transcription of target genes. In the light of recent studies AICD seems to be another product of APP proteolysis endowed with important biological functions that may contribute to Alzheimer's disease pathology.
Laboratory of Calcium Binding Proteins, Nencki Institute of Experimental Biology, Warsaw, Poland.
Lukasz P
LP
Słomnicki
Wiesława
W
Leśniak
D016564:Amyloid beta-Protein Precursor / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D045604:Extracellular Fluid / Q000378:metabolism*; D051548:Histone Acetyltransferases; D006801:Humans; D000074443:Lysine Acetyltransferase 5; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D014158:Transcription, Genetic / Q000502:physiology*
D016564:Amyloid beta-Protein Precursor; D009687:Nuclear Proteins; D051548:Histone Acetyltransferases; C098489:KAT5 protein, human; D000074443:Lysine Acetyltransferase 5