The antiproliferative effect of bovine lactoferrin on canine mammary gland tumor cells.
Lactoferrin has several biological activities, including antitumor activities in some human and animal tumor cells. Clinical trials have been carried out in human medicine based on these effects. However, the antitumor effects of lactoferrin in veterinary medicine remain unknown. In this in vitro study, we demonstrated that co-incubation of canine mammary gland tumor cells (CIPp and CHMp) and bovine lactoferrin induced growth arrest of tumor cells. This growth arrest was associated with induction of G1 arrest. Furthermore, this effect was stronger in tumor cells than in normal cells. These findings demonstrate that bovine lactoferrin has anti-tumor activity in canine mammary tumors and has the potential for use in tumor-bearing dogs.
Department of Veterinary Clinical Science, The United Graduate School of Veterinary Science, Gifu University, Gifu, Japan.
Yuichi
Y
Yamada
Reeko
R
Sato
Saori
S
Kobayashi
Careen
C
Hankanga
Osamu
O
Inanami
Mikinori
M
Kuwabara
Yutaka
Y
Momota
Nobuyuki
N
Tomizawa
Jun
J
Yasuda
D000230:Adenocarcinoma / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002417:Cattle; D045744:Cell Line, Tumor; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007781:Lactoferrin / Q000494:pharmacology*; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy*; D013997:Time Factors
D000970:Antineoplastic Agents; D007781:Lactoferrin