Morphology and surface States of colloidal probucol nanoparticles evaluated by atomic force microscopy.
Morphology and surface states of colloidal probucol nanoparticles after dispersion of probucol/polyvinylpyrrolidone (PVP)/sodium dodecyl sulphate (SDS) ternary ground mixture into water were investigated by atomic force microscopy (AFM). The observed particles had core-shell structure, i.e. drug nanocrystals were covered with PVP and SDS complex. The AFM phase image and the force curve analyses indicated that probucol nanoparticles with PVP K17 showed layer structure, compared to those with PVPK12. The structural difference was explainable in terms of the molecular states of PVP-SDS complex on the particle surface. These findings support not only the mechanism of drug nanoparticle formation but also the in vivo absorption results with the almost same particle size of ca. 40 nm.
Graduate School of Pharmaceutical Sciences, Chiba University, Japan. moribe@p.chiba-u.ac.jp
Kunikazu
K
Moribe
Chalermphon
C
Wanawongthai
Jyutaro
J
Shudo
Kenjirou
K
Higashi
Keiji
K
Yamamoto
D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D003102:Colloids; D007408:Intestinal Absorption; D008297:Male; D018625:Microscopy, Atomic Force; D053758:Nanoparticles; D010316:Particle Size; D011341:Probucol / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013499:Surface Properties; D013535:Suspensions
D000924:Anticholesteremic Agents; D003102:Colloids; D013535:Suspensions; D011341:Probucol