Parathyroid hormone is inversely related to endothelin-1 in patients on haemodialysis.
OBJECTIVE
Parathyroid hormone secretion is mainly influenced by hypocalcaemia, hyperphosphataemia and vitamin D deficiency. However, previous in vitro and in vivo studies showed that endothelin-1 can influence parathyroid hormone secretion. This study was aimed at evaluating this relationship in vivo in uraemic patients.


METHODS
Parathyroid hormone and endothelin-1 plasma concentrations were measured in 67 haemodialysed patients. Patients with history of cardiovascular diseases and those with parathyroid adenoma were excluded.


RESULTS
Plasma levels of endothelin-1 were found to be inversely related to those of parathyroid hormone (P < 0.04) The multiple regression analysis, carried out considering parathyroid hormone as a dependent variable, and including age, sex, blood pressure, calcium x phosphorus product, and endothelin-1, demonstrated that the independent correlates of parathyroid hormone were endothelin-1 (beta = -0.276; P = 0.015), and calcium x phosphorus product (beta = 0.417; P < 0.0001).


CONCLUSIONS
For the first time in vivo, we demonstrated an inverse independent relationship between endothelin-1 and parathyroid hormone in haemodialysed patients. Because both endothelin-1 and parathyroid hormone are endowed with well-known harmful actions on cardiovascular apparatus, whether such inverse relation may really influence the natural history of cardiovascular damage due to secondary hyperparathyroidism remains to be elucidated.
Palermo
Alessandro
A
Cattedra di Nefrologia, Dipartmento di Medicina Interna, Mallattie Cardiovasculari e NefroUrologiche, Hypertension Excellence Centre of the European Society of Hypertension, Università degli Studi di Palermo, Italy.
Mulè
Giuseppe
G
Guarneri
Marco
M
Arsena
Rosalia
R
Riccobene
Raffaella
R
Lorito
Maria Carmela
MC
Vaccaro
Francesco
F
Cerasola
Giovanni
G
Cottone
Santina
S
D000328:Adult; D000368:Aged; D019332:Endothelin-1 / Q000097:blood* / Q000502:physiology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D012044:Regression Analysis; D006435:Renal Dialysis
D019332:Endothelin-1; C470125:PTH protein, human; D010281:Parathyroid Hormone