Recurrent giant chalazia in hyperimmunoglobulin E (Job's) syndrome.
Hyperimmunoglobulinemia E (Job's) syndrome is a rare autosomal dominant disorder appearing early in life with recurrent skin and pulmonary infections, characterized by markedly increased serum immunoglobulin E (IgE) levels. We describe a 50-year-old man with a 4-year history of recurrent, multiple giant chalazia in all eyelids. Medications and surgical intervention had produced only transient improvement. The patient had also had pulmonary and scalp infection. Laboratory tests disclosed elevated serum IgE (>1,000 IU/ml) and eosinophilia. As a result, based on the patient's history and clinical and laboratory findings, a diagnosis of Job's syndrome was made. Even though rarely, recurrent multiple giant chalazia may occur as an ophthalmic feature of Job's syndrome. Hyperimmunoglobulinemia E syndrome should be suspected in any case of recurrent giant chalazia, regardless of the patient's age. Measurement of serum IgE and eosinophils, along with internal evaluation, is essential to establish a proper diagnosis.
Patteri
Pierpaolo
P
Department of Ophthalmology, San Francesco Hospital, Nuoro, Italy.
Serru
Alain
A
Chessa
Maria Letizia
ML
Loi
Michele
M
Pinna
Antonio
A
D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D017043:Chalazion / Q000150:complications* / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D003475:Curettage; D003907:Dexamethasone / Q000008:administration & dosage; D004318:Doxycycline / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007589:Job Syndrome / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009824:Ointments; D011182:Postoperative Care; D012008:Recurrence; D014031:Tobramycin / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D005938:Glucocorticoids; D009824:Ointments; D003907:Dexamethasone; D004318:Doxycycline; D014031:Tobramycin