Association between serum gamma-glutamyltransferase and oxidative stress related factors.
OBJECTIVE
To investigate the main factors correlated with the serum gamma-glutamyltransferase activity.


METHODS
We measured serum gamma-glutamyltransferase activity in 248 healthy Japanese people and determined its correlations with serum antioxidants, other plasma or serum factors, urinary 8-hydroxydeoxyguanine, and lifestyle factors.


RESULTS
The mean serum gamma-glutamyltransferase activity was 29 IU/L. Gamma-glutamyltransferase activities of males and persons older than 45 years were significantly higher than each counterpart. Gamma-glutamyltransferase levels increased significantly with the number of cigarettes smoked per day and the frequency of alcohol consumption except for the persons who did not take alcohol. Additionally, gamma-glutamyltransferase significantly correlated with urinary 8-hydroxydeoxyguanine, and with more blood factors including serum tocopherols, carotenoids, antioxidative enzymes, lipid peroxide, and free fatty acids than urinary 8-hydroxydeoxyguanine did. In multiple regression analyses, gamma-glutamyltransferase had significant associations with retinol, 8-hydroxydeoxyguanine, docosahexaenoic acid, and cigarette smoking.


CONCLUSIONS
Our present findings support the hypothesis that gamma-glutamyltransferase can be used as a marker related with oxidative stress.
Takigawa
Tomoko
T
Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Hibino
Yuri
Y
Kimura
Shingo
S
Yamauchi
Hiroshi
H
Wang
Bingling
B
Wang
Dahong
D
Ogino
Keiki
K
D000080242:8-Hydroxy-2'-Deoxyguanosine / Q000031:analogs & derivatives; D000328:Adult; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives / Q000652:urine; D006801:Humans; D008019:Life Style; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D005723:gamma-Glutamyltransferase / Q000097:blood*
D006147:Guanine; C078307:8-oxo-7,8-dihydrodeoxyguanine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D005723:gamma-Glutamyltransferase