Electrochemical parameters and techniques in drug development, with an emphasis on quinones and related compounds.
This review article summarizes recent applications of electrochemical techniques to redox-active drug development and mechanistic studies. It includes a general introduction to the use of electrochemistry in biology, with a focus on how electrochemistry can uniquely provide both kinetic and thermodynamic information. A number of studies are reported from the literature and the authors' laboratories, including the investigation of reactive oxygen species, biooxidative/bioreductive activation of pro-drugs, and DNA alkylation, with a particular emphasis on quinones and related compounds. Data from techniques ranging from traditional cyclic voltammetry to sophisticated single cell studies are presented. The examples herein presented illustrate how electrochemical, biochemical and medical knowledge can be integrated to develop strategies for the design and development of redox-selective therapeutics.
Hillard
Elizabeth Anne
EA
Ecole Nationale Supérieure de Chimie de Paris, Laboratoire de Chimie et Biochimie des Complexes Moléculaires, UMR CNRS-ENSCP-UPMC 7576, 11 rue Pierre et Marie Curie, 75231, Paris Cedex 05, France.
de Abreu
Fabiane Caxico
FC
Ferreira
Danielle Cristhina Melo
DC
Jaouen
Gérard
G
Goulart
Marília Oliveira Fonseca
MO
Amatore
Christian
C
D000478:Alkylation; D000900:Anti-Bacterial Agents / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000737:chemistry; D015195:Drug Design; D004563:Electrochemistry; D007700:Kinetics; D015394:Molecular Structure; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry; D011809:Quinones / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013816:Thermodynamics
D000900:Anti-Bacterial Agents; D004364:Pharmaceutical Preparations; D011355:Prodrugs; D011809:Quinones; D004247:DNA