[Chemotherapy-induced cardiotoxicity in the elderly].
Chemotherapy-induced cardiotoxicity can concern major effects, inducing severe impairments of vital functions: systolic or diastolic function, hypertension, rhythmic or conducting pathology, Elsewhere, cardiac and vascular aging induces alterations, which concern roughly the same points and are enhanced by vascular risk factors. We wish to analyse the correlation and increase of the consequences of the first one toward the second one and the safe attitude we must have for those patients (prevention and early treatment). Echocardiography seems to have more and more a major status to assess cardiac function, chiefly in systolic and diastolic manor. We insist on the interest of stress echo for assessment of impaired contractility and for evaluation of vascular risk in ischemic disease. We suggest a vulnerability score to predict the risk of complication due to chemotherapy.
Bernard
Michel
M
Service de cardiologie, hôpital Tenon, Université Pierre et Marie Curie, 75020 Paris, France.
Avenin
Danièle
D
Selle
Frédéric
F
Gligorov
Joseph
J
Houssel
Pauline
P
Carette
Benoit
B
Bourayou
Nawel
N
Lokiec
François
F
Carola
Elisabeth
E
Lotz
Jean-Pierre
JP
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D006801:Humans
D000970:Antineoplastic Agents