Different effect of laparoscopic Roux-en-Y gastric bypass and open biliopancreatic diversion of Scopinaro on serum PYY and ghrelin levels.
BACKGROUND
The impact of bariatric surgery on levels of peptide YY (PYY) and ghrelin is still under discussion. We undertook a simultaneous evaluation of the serum changes in PYY and ghrelin depending on the specific type of bariatric surgery.


METHODS
Total PYY and ghrelin were analyzed in 29 healthy persons and in morbidly obese persons undergoing open biliopancreatic diversion (BPD) of Scopinaro (n = 38) or laparoscopic Roux-en-Y gastric bypass (RYGB; n = 13).


RESULTS
RYGB resulted in a significantly greater loss of weight and body mass index than BPD. Both RYGB and BPD were associated with a significant increase in PYY, significantly greater for BDP (p = 0.001). Ghrelin rose significantly after RYGB (p = 0.022) but not after BPD. After surgery, PYY correlated positively with weight (r = 0.416, p = 0.009). Ghrelin did not correlate significantly with any of the variables studied. Analysis of variance showed that only the type of surgery contributed significantly to explain the variances in the PYY (p = 0.002) and ghrelin (p = 0.018).


CONCLUSIONS
BPD results in a greater increase in PYY and a lower weight loss than RYGB. However, only RYGB was associated with a significant increase in ghrelin. The differing weight loss according to the type of bariatric surgery does not seem to be explained by changes arising in PYY and ghrelin.
Garcia-Fuentes
E
E
Fundación IMABIS, Málaga, Spain. edugf1@gmail.com
Garrido-Sanchez
L
L
Garcia-Almeida
J M
JM
Garcia-Arnes
J
J
Gallego-Perales
J L
JL
Rivas-Marin
J
J
Morcillo
S
S
Cardona
I
I
Soriguer
F
F
D000328:Adult; D015904:Biliopancreatic Diversion / Q000379:methods; D015992:Body Mass Index; D005260:Female; D015390:Gastric Bypass; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery; D019894:Peptide YY / Q000097:blood*; D016896:Treatment Outcome; D015431:Weight Loss
D054439:Ghrelin; D019894:Peptide YY