Bridging innate and adaptive immunity through gammadelta T-dendritic cell crosstalk.
Like Natural Killer cells, gammadelta T cells and Natural Killer T cells display several innate-like features that confer them a broad reactivity against tumors and pathogens. By recognizing stress-induced conserved antigens upregulated a wide array of physiopathological contexts, these lymphoid subsets develop strong and early responses to a broad set of targets. One of the most exciting roles possibly played in vivo by non-conventional T lymphocytes, which exhibit a biased natural memory phenotype, is active regulation of adaptive immune responses through interactions with antigen presenting cells (APCs), such as dendritic cells. Here we will review recent studies reporting functional interactions between gammadelta T cells and APC and a possible involvement of these lymphocytes in bridging innate and adaptative immunity along infections and tumor development. Our discussion will focus on human gammadelta T cells and more specifically on Vgamma9Vdelta2 T cells, a major subset found in human peripheral blood.
INSERM U892, Departement de Recherche en Cancerologie Nantes-Angers, Nantes, France. Emmanuel.Scotet@nantes.inserm.fr
Emmanuel
E
Scotet
Steven
S
Nedellec
Marie-Claire
MC
Devilder
Sophie
S
Allain
Marc
M
Bonneville
D000818:Animals; D002450:Cell Communication; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D008285:Major Histocompatibility Complex / Q000276:immunology; D023421:Models, Animal; D009000:Monocytes / Q000276:immunology / Q000502:physiology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology
D016692:Receptors, Antigen, T-Cell, gamma-delta