Human milk consumption and full enteral feeding among infants who weigh </= 1250 grams.
OBJECTIVE
Establishing enteral feeding is an important goal in the care of very low birth weight infants. In such infants, receipt of >/=50 mL/kg per day human milk during hospitalization has been associated with shorter time to full enteral feeding. The objective of this study was to determine whether high proportions (>/=50%) of human milk during feeding advancement are associated with shorter time to full enteral feeding and improved feeding tolerance.


METHODS
This was a prospective cohort study of very low birth weight infants (n = 127) who were grouped into low (<50%; n = 34) and high (>/=50%; n = 93) human milk consumption groups according to their human milk proportion of enteral feeding during the time of feeding advancement. The primary outcomes of interest were ages at which 100 and 150 mL/kg per day enteral feedings were achieved.


RESULTS
The high human milk group reached 100 mL/kg per day enteral feeding 4.5 days faster than the low human milk group. The high human milk group reached 150 mL/kg per day enteral feeding 5 days faster than the low human milk group. After adjustment for gestational age, gender, and respiratory distress syndrome, times to reach 100 and 150 mL/kg per day were significantly shorter for those in the high human milk group. Infants in the high human milk group had a greater number of stools per day; other indicators of feeding tolerance were not statistically different.


CONCLUSIONS
In infants who weighed </=1250 g, enteral feeding that contained at least 50% maternal human milk was associated with fewer days to full enteral feedings.
Department of Pediatrics, Wake Forest University School of Medicine, One Medical Center Blvd, Winston-Salem, NC 27157, USA. psisk@wfubmc.edu
Paula M
PM
Sisk
Cheryl A
CA
Lovelady
Kenneth J
KJ
Gruber
Robert G
RG
Dillard
T Michael
TM
O'Shea
D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D011446:Prospective Studies