A network model for activity-dependent sleep regulation.
We develop and characterize a dynamical network model for activity-dependent sleep regulation. Specifically, in accordance with the activity-dependent theory for sleep, we view organism sleep as emerging from the local sleep states of functional units known as cortical columns; these local sleep states evolve through integration of local activity inputs, loose couplings with neighboring cortical columns, and global regulation (e.g. by the circadian clock). We model these cortical columns as coupled or networked activity-integrators that transition between sleep and waking states based on thresholds on the total activity. The model dynamics for three canonical experiments (which we have studied both through simulation and system-theoretic analysis) match with experimentally observed characteristics of the cortical-column network. Most notably, assuming connectedness of the network graph, our model predicts the recovery of the columns to a synchronized state upon temporary overstimulation of a single column and/or randomization of the initial sleep and activity-integration states. In analogy with other models for networked oscillators, our model also predicts the possibility for such phenomena as mode-locking.
Department of Electrical Engineering, Washington State University, P.O. Box 642752, Pullman, WA 99164, USA. sroy@eecs.wsu.edu
Sandip
S
Roy
James M
JM
Krueger
David M
DM
Rector
Yan
Y
Wan
D000818:Animals; D001683:Biological Clocks / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D012890:Sleep / Q000502:physiology*