Glial cross-talk by transmembrane chemokines CX3CL1 and CXCL16.
The transmembrane chemokines CX3CL1 and CXCL16 mediate chemotaxis and cell to cell adhesion by interaction with their receptors CXCR6 and CX3CR1, respectively. We here summarize reports on the expression, regulation and proteolytic processing of transmembrane chemokines by glial cells, their activity on glial cells/glial precursor cells and their role in glial cell cross-talk under physiological and pathophysiological conditions.
Ludwig
Andreas
A
Institute of Pharmacology and Toxicology, University Hospital RWTH Aachen, Germany. aludwig@ukaachen.de
Mentlein
Rolf
R
D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D054360:Chemokine CXCL1 / Q000502:physiology*; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D009457:Neuroglia / Q000502:physiology*; D051116:Receptors, Scavenger / Q000502:physiology*
C423727:CXCL16 protein, human; D054360:Chemokine CXCL1; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC; D051116:Receptors, Scavenger