The role of chemokines during herpes simplex virus-1 infection.
Herpes simplex virus-type 1 is among the most prevalent and successful humans pathogens. Although infection is largely uncomplicated in the immunocompetent human host, HSV-1 infection can cause blinding corneal disease, and individuals with defects in innate or adaptive immunity are susceptible to herpes simplex encephalitis. Chemokines regulate leukocyte trafficking to inflamed tissues and play a crucial role in orchestrating the immune response to HSV-1 infection. In this review we will focus on the pathways that induce chemokine expression during HSV-1 infection and the implications of chemokine signaling on control of viral replication.
Department of Microbiology, Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Todd R
TR
Wuest
Daniel J J
DJ
Carr
D002490:Central Nervous System / Q000503:physiopathology / Q000821:virology; D018925:Chemokines / Q000502:physiology*; D017950:Ganglia, Sensory / Q000503:physiopathology; D006561:Herpes Simplex / Q000276:immunology / Q000503:physiopathology*; D018259:Herpesvirus 1, Human / Q000502:physiology; D006801:Humans; D015398:Signal Transduction; D017735:Virus Latency; D014779:Virus Replication
D018925:Chemokines