[Effect of zedoary turmeric oil-eluting stents for post-stenting restenosis prevention and treatment].
OBJECTIVE
To investigate the effect and safety of Zedoary Turmeric Oil (ZTO)-eluting stents for post-coronary stenting restenosis prevention and treatment in the experimental dogs.


METHODS
Bare stents, stents coated with polybutyl methacrylate/Nano silica, and stents eluted with 100 microg ZTO were randomly deployed in canine anterior descending or circumflex coronary artery. Four weeks after stent implantation, the dogs were sacrificed and the vascular histomorphologic changes in the stenting segment analyzed.


RESULTS
Thickened intima could be seen under light microscope in the bare or coated stents, but thinner in ZTO-duting stent, with no sub-intimal hemorrhage, medial or adventitial necrosis, wall adhesive thrombus, or infiltration of inflammatory cells. Scanning electric microscopy showed the intima was intact. Histomorphologic analysis showed that the thickness and area of neo-intima, and the lumen stenosis percent in artery stented with ZTO eluting stents were significantly lower than those stented with bare or coated stents (P <0.01), and thus the lumen cavity was expanded (P < 0.01), while no statistic significant difference between polymer and bare stents was found (P > 0.05).


CONCLUSIONS
ZTO-eluting stent is available and safe, and it could significantly inhibit the growth of neo-intimal in canine coronary mode after stenting, showing a restenosis preventive and treatment effect.
Zhao
Jun-Li
JL
Department of Cardiology, The Afiliated First People's Hospital of Shanghai Jiaotong University, Shanghai. jlzhao2008cn@yahoo.com.cn
Sun
Bao-Gui
BG
Wen
Qin-Zhu
QZ
D000818:Animals; D023903:Coronary Restenosis / Q000188:drug therapy* / Q000517:prevention & control*; D030024:Curcuma / Q000737:chemistry*; D004195:Disease Models, Animal; D004285:Dogs; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D010938:Plant Oils / Q000008:administration & dosage*; D011897:Random Allocation
D010936:Plant Extracts; D010938:Plant Oils; C012596:turmeric extract