Moving towards a better understanding of chemotaxis.
Eukaryotic cells are thought to move across supporting surfaces through a combination of coordinated processes: polarisation; extension of dynamic protrusions from a leading edge; adhesion-associated stabilisation of some protrusions; centripetal pulling against those leading adhesions; and de-adhesion at the rear. Gradients of extracellular ligands can be detected by cells and then used to guide them either towards the source (in the case of a chemoattractant) or away from the source (in the case of a chemorepellent)--such migration is termed chemotaxis. Recent work suggests that chemotaxis probably emerges from the ability of cells to spatially encode extracellular gradients of ligands, a process for which phosphoinositide 3'-kinase (PI3K) signals alone are insufficient, and to use that vectorial information to bias movement by enhancing the survival, and not the formation, of the protrusions that experience the greatest stimulation.
The Inositide Lab, The Babraham Institute, Cambridge CB2 4AT, UK. len.stephens@bbsrc.ac.uk
Len
L
Stephens
Laura
L
Milne
Phillip
P
Hawkins
D000818:Animals; D002630:Chemotactic Factors / Q000502:physiology; D002633:Chemotaxis / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology; D004023:Dictyostelium / Q000502:physiology*; D009504:Neutrophils / Q000502:physiology*; D018129:Phosphatidylinositol Phosphates / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D002630:Chemotactic Factors; D018129:Phosphatidylinositol Phosphates; C060974:phosphatidylinositol 3,4,5-triphosphate; D000242:Cyclic AMP