LOT: a tool for linkage analysis of ordinal traits for pedigree data.
CONCLUSIONS
Existing linkage-analysis methods address binary or quantitative traits. However, many complex diseases and human conditions, particularly behavioral disorders, are rated on ordinal scales. Herein, we introduce, LOT, a tool that performs linkage analysis of ordinal traits for pedigree data. It implements a latent-variable proportional-odds logistic model that relates inheritance patterns to the distribution of the ordinal trait. The likelihood-ratio test is used for testing evidence of linkage.


BACKGROUND
The LOT program is available for download at http://c2s2.yale.edu/software/LOT/
Zhang
Meizhuo
M
Yale University School of Medicine, New Haven, CT 06520-8034, USA.
Feng
Rui
R
Chen
Xiang
X
Hu
Buqu
B
Zhang
Heping
H
D000465:Algorithms; D002874:Chromosome Mapping / Q000379:methods*; D003198:Computer Simulation; D008040:Genetic Linkage / Q000235:genetics*; D008957:Models, Genetic; D010375:Pedigree; D012984:Software