Protein tyrosine phosphatases in the JAK/STAT pathway.
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is crucial in controlling cellular activities in response to extracellular cytokines. Dysfunctions of the JAK/STAT pathway result in various hematopoietic and immune disorders. The central events in regulating this pathway are tyrosine phosphorylation and dephosphorylation of the signaling components, which are carried out by protein tyrosine kinases and protein tyrosine phosphatases (PTP), respectively. Here, we review recent advances in the regulatory roles of PTPs, in particular, SHP2 phosphatase, in the JAK/STAT signaling pathway.
Department of Medicine, Division of Hematology/Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Dan
D
Xu
Cheng-Kui
CK
Qu
D006801:Humans; D053613:Janus Kinase 1 / Q000378:metabolism; D053612:Janus Kinases / Q000378:metabolism*; D017493:Leukocyte Common Antigens / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000378:metabolism*; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6 / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D017467:Receptors, Erythropoietin / Q000502:physiology; D015398:Signal Transduction; D015534:Trans-Activators; D018909:src Homology Domains
D017467:Receptors, Erythropoietin; D015534:Trans-Activators; D053613:Janus Kinase 1; D053612:Janus Kinases; D017346:Protein Serine-Threonine Kinases; D017493:Leukocyte Common Antigens; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases