Comparison of soybean oil- and olive oil-based lipid emulsions on hepatobiliary function and serum triacylglycerols level during realimentation.
This study compared the effects of soybean oil- versus olive oil-based lipid emulsions on hepatobiliary function and serum triacylglycerols in patients who required transient parenteral nutrition support for significant weight loss. Patients who received a parenteral ready-to-use industry admixture including either soybean oil- (n = 10) or olive oil-based lipid emulsion (n = 11) for 2 weeks were retrospectively analysed. Cholestatic and cytolytic enzymes, conjugated bilirubin and serum triacylglycerols were sampled before and 1 day after completing parenteral nutrition support. Significant deterioration of cholestatic enzymes occurred in five patients in the soybean oil group and in one in the olive oil group. Serum triacylglycerols significantly deteriorated in seven patients in the soybean oil group and in one patient in the olive oil group. No differences were recorded for cytolytic enzyme abnormalities. In conclusion, the olive oil-based emulsion induced abnormalities of cholestatic enzymes and serum triacylglycerols significantly less frequently than the soybean oil-based emulsion.
Medical Department, Second Faculty of Medicine, Charles University, V Uvalu 84, Prague 5, Czech Republic. kozakovas@seznam.cz
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S
Pálová
J
J
Charvat
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M
Kvapil
D001659:Biliary Tract / Q000187:drug effects* / Q000502:physiology*; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D010288:Parenteral Nutrition; D010938:Plant Oils / Q000008:administration & dosage*; D013024:Soybean Oil / Q000008:administration & dosage*; D014280:Triglycerides / Q000097:blood*; D015431:Weight Loss / Q000187:drug effects
D005217:Fat Emulsions, Intravenous; D000069463:Olive Oil; D010938:Plant Oils; D014280:Triglycerides; D013024:Soybean Oil