Pulmonary nocardiosis with brain abscess in a sensitized kidney transplant recipient with a history of repeated graft loss and HLA-antibody depletion treatment--a case report.
Nocardiosis is an opportunistic infection with unfavourable prognosis and is predominantly seen in immunocompromised patients. We here present a kidney transplant recipient with a history of two early graft losses who subsequently developed Human Leukocyte Antigen (HLA)-antibodies and underwent a desensitization treatment with plasmapheresis and monoclonal anti-CD20 antibody application. However, 3 months after a third HLA-identical kidney transplantation he developed Nocardiosis with pulmonary and asymptomatic brain manifestation. The present case report exemplifies this opportunistic infection and gives an overview of the literature.
Biglarnia
Ali-Reza
AR
Department of Surgical Sciences, Section of Transplantation Surgery, Uppsala University Hospital, Uppsala, Sweden. alireza.biglarnia@akademiska.se
Wadström
Jonas
J
Tufveson
Gunnar
G
Eriksson
Britt-Marie
BM
D001323:Autoantibodies / Q000276:immunology / Q000302:isolation & purification*; D001922:Brain Abscess / Q000150:complications / Q000628:therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage; D016572:Cyclosporine / Q000008:administration & dosage; D006084:Graft Rejection; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016030:Kidney Transplantation; D008171:Lung Diseases / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009617:Nocardia Infections / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome
D001323:Autoantibodies; D006680:HLA Antigens; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003520:Cyclophosphamide