5-Substituted isophthalamides as insulin receptor sensitizers.
A novel series of 5-substituted isophthalamides and their structure-activity relationship as insulin receptor sensitizers is discussed.
Robinson
Louise
L
Telik, Inc., 3165 Porter Drive., Palo Alto, CA 94304, USA.
Bajjalieh
Sonia
S
Cairns
Nicholas
N
Lum
Robert T
RT
Macsata
Robert W
RW
Manchem
Vara Prasad
VP
Park
Sophia J
SJ
Rao
Sandhya
S
Schow
Steven R
SR
Shi
Songyuan
S
Spevak
Wayne R
WR
D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects* / Q000378:metabolism; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005947:Glucose / Q000493:pharmacokinetics; D007328:Insulin / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D011972:Receptor, Insulin / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000577:Amides; D007328:Insulin; D011972:Receptor, Insulin; D005947:Glucose