Synthesis of 3',4'-epoxynoraristeromycin analogs for molecular labeling probe of S-adenosyl-l-homocysteine hydrolase.
3',4'-epoxynoraristeromycin analogs were designed and synthesized. Their affinities with human and Plasmodium falciparum S-adenosyl-l-homo-cysteine hydrolase were investigated.
Kojima
Hiroharu
H
Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1-1, Gifu 501-1193, Japan.
Kozaki
Atsushi
A
Iwata
Masafumi
M
Ando
Takayuki
T
Kitade
Yukio
Y
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D043383:Adenosylhomocysteinase / Q000737:chemistry* / Q000378:metabolism*; D000818:Animals; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015335:Molecular Probes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000201:enzymology
C530491:3',4'-epoxynoraristeromycin; D015335:Molecular Probes; C030034:aristeromycin; D043383:Adenosylhomocysteinase; D000241:Adenosine