Toxic epidermal necrolysis after paroxetine treatment.
Toxic epidermal necrolysis (TEN) is a rare complication of paroxetine treatment and can be life-threatening. We report a case of paroxetine-induced TEN in an 80-year-old Maori female. She was started on paroxetine 10 mg once daily 6 days prior to hospital admission. The patient then developed extensive vesiculobullous skin eruptions. She was treated with intravenous fluid, corticosteroid, and local dressings and concurrently her paroxetine was stopped. A series of laboratory investigations were carried out and a final diagnosis of TEN was made from skin biopsy. The patient was discharged home after 2 weeks of treatment. Her skin lesions improved gradually.
Rashid
R
Ahmed
Carl
C
Eagleton
D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D003866:Depressive Disorder / Q000188:drug therapy*; D003937:Diagnosis, Differential; D005194:Family Practice; D005260:Female; D006801:Humans; D017374:Paroxetine / Q000009:adverse effects* / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
D000893:Anti-Inflammatory Agents; D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine; D011241:Prednisone