Bone density of the femur and fiber cross-sectional area and oxidative enzyme activity of the tibialis anterior muscle in type II collagen-induced arthritic mice.
Femur bone densities and tibialis anterior muscle properties of type II collagen-induced arthritic mice were determined. Furthermore, voluntary running activities of arthritic mice were compared with those of controls. Arthritis was induced by an intradermal injection of type II collagen in the adjuvant. Body and muscle weights were lower in arthritic mice than in controls. Cortical and trabecular bone densities and muscle fiber cross-sectional areas were decreased by arthritis. After classifying the arthritic severity into slight, intermediate, and severe levels based on the degree of knuckle swelling, cortical and trabecular bone densities, fiber cross-sectional areas, and fiber succinate dehydrogenase activities were lowest when arthritis was most severe. Furthermore, arthritic mice, especially those with intermediate and severe levels, showed lower voluntary running activities. These findings indicate that lower bone density and muscle atrophy of type II collagen-induced arthritic mice are related to arthritic severity and decreased motor activity.
Research and Development Center, Nippon Meat Packers Inc., Tsukuba, 300-2646 Japan.
Tomonori
T
Okiura
Fumiko
F
Nagatomo
Ning
N
Gu
Yasuki
Y
Taguchi
Fumiki
F
Morimatsu
Akihiko
A
Ishihara
D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology* / Q000503:physiopathology; D001835:Body Weight; D015519:Bone Density; D024043:Collagen Type II; D005269:Femur / Q000473:pathology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009043:Motor Activity; D018485:Muscle Fibers, Skeletal / Q000201:enzymology / Q000473:pathology; D018482:Muscle, Skeletal / Q000201:enzymology / Q000473:pathology* / Q000503:physiopathology; D009133:Muscular Atrophy / Q000201:enzymology / Q000473:pathology; D009929:Organ Size; D012420:Running; D012720:Severity of Illness Index; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D024043:Collagen Type II; D013385:Succinate Dehydrogenase