N-propargylic beta-enaminones: common intermediates for the synthesis of polysubstituted pyrroles and pyridines.
N-Propargylic beta-enaminones have been used as common intermediates for the synthesis of polysubstituted pyrroles and pyridines. Best results have been obtained using DMSO as solvent. In the presence of Cs(2)CO(3) N-propargylic beta-enaminones are cyclized to pyrroles in good to high yields, whereas omitting bases and using CuBr leads to the selective formation of pyridines.
Cacchi
Sandro
S
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi La Sapienza, P.le A. Moro 5, 00185, Rome, Italy. sandro.cacchi@uniroma1.it
Fabrizi
Giancarlo
G
Filisti
Eleonora
E