EpCAM in morphogenesis.
Embryonic development is one of the most complex biological phenomena that involves the appropriate expression and synchronized interactions of a plethora of proteins, including cell adhesion molecules (CAMs). Many members of the diverse family of CAMs have been shown to be critically involved in the correct execution of embryonic development. The Epithelial Cell Adhesion Molecule (EpCAM) is an atypical cell adhesion molecule originally identified as a marker for carcinoma. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. All of these processes are known to be fundamental for morphogenesis. Here, we review the current literature that establishes EpCAM as a protein involved in morphogenesis, starting from the earliest stages of embryogenesis and ending in organogenesis. In addition, we provide directions for further elucidation of the role of EpCAM in embryogenesis.
University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Monika
M
Trzpis
Edwin
E
Bremer
Pamela M J
PM
McLaughlin
Lou F M H
LF
de Leij
Martin C
MC
Harmsen
D000818:Animals; D000951:Antigens, Neoplasm / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000502:physiology*; D047108:Embryonic Development; D000071858:Epithelial Cell Adhesion Molecule; D006801:Humans; D007668:Kidney / Q000196:embryology; D008168:Lung / Q000196:embryology; D009024:Morphogenesis / Q000502:physiology*; D038081:Organogenesis / Q000502:physiology*; D010179:Pancreas / Q000196:embryology
D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D000071858:Epithelial Cell Adhesion Molecule