[The study of therapeutic effect of synthetic bradykinin "gene" contained in retrovirus vector on spontaneously hypertensive rats].
Administration of DNA plasmid pPS-3-neo (brd) with synthetic bradykinin " gene " to 2-days old male spontaneously hypertensive rats (SHR) leads to 2 weeks delay in development of arterial hypertension. Lowering of SBP and positive results of PCR DNA of various organs observed in synthetic bradykinin " gene " transgenic SHR but not in control SHR confirm therapeutic effect of synthetic bradykinin " gene " . This data indicate one of possible ways of gene therapy of arterial hypertension as well as other pathological states by introduction of transgene directly into genome of the organism.
Neverova
M E
ME
Fidelina
O V
OV
Mkrtumova
N A
NA
Postnov
A Iu
AIu
Postnova
D A
DA
Kalinin
V N
VN
D000818:Animals; D001920:Bradykinin / Q000235:genetics* / Q000494:pharmacology; D002472:Cell Transformation, Viral / Q000187:drug effects / Q000235:genetics; D004195:Disease Models, Animal; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors / Q000494:pharmacology*; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D008297:Male; D010957:Plasmids; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012190:Retroviridae / Q000235:genetics*; D014162:Transfection / Q000379:methods; D016896:Treatment Outcome
D001920:Bradykinin