Liver ultrastructural morphology and mitochondrial DNA levels in HIV/hepatitis C virus coinfection: no evidence of mitochondrial damage with highly active antiretroviral therapy.
Liver mitochondrial toxicity is a concern, particularly in HIV/hepatitis C virus (HCV) coinfection. Liver biopsies from HIV/HCV co-infected patients, 14 ON-highly active antiretroviral therapy (HAART) and nine OFF-HAART, were assessed by electron microscopy quantitative morphometric analyses. Hepatocytes tended to be larger ON-HAART than OFF-HAART (P = 0.05), but mitochondrial volume, cristae density, lipid volume, mitochondrial DNA and RNA levels were similar. We found no evidence of increased mitochondrial toxicity in individuals currently on HAART, suggesting that concomitant HAART should not delay HCV therapy.
Matsukura
Motoi
M
Department of Pathology and Laboratory Medicine, University of British Columbia, Canada.
Chu
Fanny F S
FF
Au
May
M
Lu
Helen
H
Chen
Jennifer
J
Rietkerk
Sonja
S
Barrios
Rolando
R
Farley
John D
JD
Montaner
Julio S
JS
Montessori
Valentina C
VC
Walker
David C
DC
Côté
Hélène C F
HC
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D015331:Cohort Studies; D004272:DNA, Mitochondrial / Q000648:ultrastructure*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000648:ultrastructure*
D004272:DNA, Mitochondrial