Negishi cross-couplings of unsaturated halides bearing relatively acidic hydrogen atoms with organozinc reagents.
A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated halides bearing an acidic NH or OH function, using Pd(OAc)(2) (1 mol %) and S-Phos (2 mol %) as catalyst without the need of protecting groups.
Department Chemie and Biochemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 München, Germany.
Georg
G
Manolikakes
Matthias A
MA
Schade
Carmen Muñoz
CM
Hernandez
Herbert
H
Mayr
Paul
P
Knochel