Developmental effects of Tityus serrulatus scorpion venom on the rat offspring.
Scorpion envenomation is a public health problem. Extensive research has been conducted to describe the systemic effects of scorpion venoms and their toxins, however, few reports are available about their effects on pre- and post-natal periods. Whole venom of the Tityus serrulatus scorpion was administered to rats on the 10th and 16th days of pregnancy to determine the effect on physical, reflexive and behavioral development of offspring. Thirty female Wistar rats were mated and distributed into three groups with one control group (C) and two experimental groups that were injected with venom (1mg/kg) on the 10th (GD10) or the 16th day (GD16) of pregnancy. After birth, the litter was standardized (eight pups for dam) and the rat pups were submitted to physical and behavioral analysis. A greater weight gain was observed on the 20th day of life (PN20) in the female and male pups of the two experimental groups compared to controls. In the GD16 group, a delay in ear opening and acceleration in ear unfolding were observed. In relation to reflexive development, an increased time for palmar grasp reflex was observed on PN8 in GD16. For this group, there was a decrease in the time of righting reflex on PN4 and PN6, and of negative geotaxis on PN6, PN8 and PN10. In conclusion, scorpion venom administered to pregnant rats on specific gestational days and at a dose that simulates a small accident, results in alterations in some reflex and physical parameters in their offspring.
Laboratory of Pharmacology, Butantan Institute and Center of Disease Control, SES, São Paulo, SP 05503-900, Brazil. alineasb@butantan.gov.br
Aline Aparecida Saltão
AA
Barão
Rogerio Gentil
RG
Bellot
Valquiria Abrão Coronado
VA
Dorce
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects; D012604:Scorpion Venoms / Q000494:pharmacology*; D015430:Weight Gain
D012604:Scorpion Venoms