Food group intake and risk of subtypes of esophageal and gastric cancer.
Incidence rates for adenocarcinomas of the esophagus and gastric cardia have been increasing rapidly, while rates for non-cardia gastric adenocarcinoma and esophageal squamous cell carcinoma have declined. We examined food group intake as a risk factor for subtypes of esophageal and gastric cancers in a multicenter, population-based case-control study in Connecticut, New Jersey and western Washington state. Associations between food groups and risk were estimated using adjusted odds ratios (OR), based on increasing intake of one serving per day. Total vegetable intake was associated with decreased risk of esophageal adenocarcinoma (OR = 0.85, 95% CI = 0.75, 0.96). Conversely, total meat intake was associated with increased risk of esophageal adenocarcinoma (OR = 1.43, 95% CI = 1.11, 1.83), gastric cardia adenocarcinoma (OR = 1.37, 95% CI = 1.08, 1.73) and noncardia gastric adenocarcinoma (OR = 1.39, 95% CI = 1.12, 1.71), with red meat most strongly associated with esophageal adenocarcinoma risk (OR = 2.49, 95% CI = 1.39, 4.46). Poultry was most strongly associated with gastric cardia adenocarcinoma (OR = 1.89, 95% CI = 1.15, 3.11) and noncardia gastric adenocarcinoma (OR = 1.90, 95% CI = 1.19, 3.03). High-fat dairy was associated with increased risk of both esophageal and gastric cardia adenocarcinoma. Higher intake of meats, particularly red meats, and lower intake of vegetables were associated with an increased risk of esophageal adenocarcinoma, while higher intake of meats, particularly poultry, and high-fat dairy was associated with increased risk of gastric cardia adenocarcinoma.
Department of Health and Nutrition Sciences, Montclair State University, Montclair, NJ 07043, USA. silveras@mail.montclair.edu
Stephanie A
SA
Navarro Silvera
Susan T
ST
Mayne
Harvey
H
Risch
Marilee D
MD
Gammon
Thomas L
TL
Vaughan
Wong-Ho
WH
Chow
Robert
R
Dubrow
Janet B
JB
Schoenberg
Janet L
JL
Stanford
A Brian
AB
West
Heidrun
H
Rotterdam
William J
WJ
Blot
Joseph F
JF
Fraumeni
D000230:Adenocarcinoma / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D002299:Cardia / Q000473:pathology; D016022:Case-Control Studies; D004032:Diet; D004938:Esophageal Neoplasms / Q000453:epidemiology*; D005260:Female; D005638:Fruit; D006801:Humans; D008297:Male; D008460:Meat; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology; D014675:Vegetables