SUMO takes control of a ubiquitin-specific protease.
In this issue of Molecular Cell, Meulmeester et al. (2008) identify USP25 as a SUMO2/3-interacting protein and substrate. A USP25 SUMO interaction motif directs SUMO2/3 specificity, and SUMO modification diminishes USP25's ability to bind and degrade polyubiquitin chains.
Mohideen
Firaz
F
Structural Biology Program, Sloan-Kettering Institute, New York, NY 10021, USA.
Lima
Christopher D
CD
D020816:Amino Acid Motifs; D006801:Humans; D006868:Hydrolysis; D025821:Polyubiquitin / Q000378:metabolism; D011485:Protein Binding; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase / Q000235:genetics / Q000378:metabolism*
D025841:Small Ubiquitin-Related Modifier Proteins; C404488:USP25 protein, human; D025821:Polyubiquitin; D043222:Ubiquitin Thiolesterase