EPR oximetry in three spatial dimensions using sparse spin distribution.
A method is presented to use continuous wave electron paramagnetic resonance imaging for rapid measurement of oxygen partial pressure in three spatial dimensions. A particulate paramagnetic probe is employed to create a sparse distribution of spins in a volume of interest. Information encoding location and spectral linewidth is collected by varying the spatial orientation and strength of an applied magnetic gradient field. Data processing exploits the spatial sparseness of spins to detect voxels with nonzero spin and to estimate the spectral linewidth for those voxels. The parsimonious representation of spin locations and linewidths permits an order of magnitude reduction in data acquisition time, compared to four-dimensional tomographic reconstruction using traditional spectral-spatial imaging. The proposed oximetry method is experimentally demonstrated for a lithium octa-n-butoxy naphthalocyanine (LiNc-BuO) probe using an L-band EPR spectrometer.
Department of Electrical and Computer Engineering, The College of Engineering, The Ohio State University, 2015 Neil Avenue, Columbus, OH 43210-1272, USA.
Subhojit
S
Som
Lee C
LC
Potter
Rizwan
R
Ahmad
Deepti S
DS
Vikram
Periannan
P
Kuppusamy
D000465:Algorithms; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D010092:Oximetry / Q000379:methods*; D013113:Spin Labels
D013113:Spin Labels