[Interferon-alpha: a key cytokine in systemic lupus erythematosus pathogenesis].
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by a chronic inflammation affecting multiple tissues and the production of antibodies directed against nuclear antigens. Leading observations in patients suggested years ago that interferon-alpha (IFNalpha) was involved in SLE pathogenesis. These observations have now been confirmed in SLE-prone mice. New promising therapeutic strategies, aiming at neutralizing IFNalpha or its effects, are currently under development.
Service de médecine interne, centre de référence national pour les lupus et le syndrome des antiphospholipides, CHU Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 75651 Paris cedex 13, France. alexis.mathian@free.fr
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Mathian
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Koutouzov
D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects / Q000097:blood / Q000502:physiology*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000209:etiology / Q000276:immunology*
D016898:Interferon-alpha