Carbaporphyrin ketals as potential agents for a new photodynamic therapy treatment of leishmaniasis.
Dimethyl and diethyl carbaporphyrin ketals inhibit the growth of Leishmania tarentolae promastigotes in vitro. The concentration dependency of the inhibitory effect was tested using the MTT assay. The presence of reactive oxygen species, such as singlet oxygen and superoxide, was detected using electron paramagnetic resonance spectroscopy with selected spin traps and confocal microscopy in cultures exposed to these carbaporphyrin ketals. These unique porphyrinoids show promise as potent inhibitors of Leishmania.
Morgenthaler
Justin B
JB
Department of Chemistry, Illinois State University Normal, IL 61790-4160, USA.
Peters
Steven J
SJ
Cedeño
David L
DL
Constantino
Manuel H
MH
Edwards
Kevin A
KA
Kamowski
Erin M
EM
Passini
Jennifer C
JC
Butkus
Brian E
BE
Young
Alexandra M
AM
Lash
Timothy D
TD
Jones
Marjorie A
MA
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D007891:Leishmania / Q000187:drug effects*; D007896:Leishmaniasis / Q000628:therapy*; D018613:Microscopy, Confocal; D010778:Photochemotherapy / Q000379:methods*; D011166:Porphyrins / Q000494:pharmacology / Q000627:therapeutic use*; D017382:Reactive Oxygen Species / Q000032:analysis; D014344:Trypanocidal Agents
D011166:Porphyrins; D017382:Reactive Oxygen Species; D014344:Trypanocidal Agents