Cooperative catalysis with chiral Brønsted acid-Rh2(OAc)4: highly enantioselective three-component reactions of diazo compounds with alcohols and imines.
An asymmetric three-component reaction of diazo compounds and alcohols with imines catalyzed cooperatively by a rhodium complex and a chiral Brønsted acid provides a general and efficient entry to beta-amino-alpha-hydroxyl acid derivatives in high yields with excellent stereoselectivities.
Hu
Wenhao
W
Department of Chemistry, East China Normal University, Shanghai 200062, China. whu@chem.ecnu.edu.cn
Xu
Xinfang
X
Zhou
Jing
J
Liu
Wei-Jun
WJ
Huang
Haoxi
H
Hu
Juan
J
Yang
Liping
L
Gong
Liu-Zhu
LZ