Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA.
Pellicciari
Roberto
R
Dipartimento di Chimica e Tecnologia del Farmaco, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy. rp@unipg.it
Venturoni
Francesco
F
Bellocchi
Daniele
D
Carotti
Andrea
A
Marinozzi
Maura
M
Macchiarulo
Antonio
A
Amori
Laura
L
Schwarcz
Robert
R
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D017124:Conserved Sequence; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000378:metabolism; D007737:Kynurenine / Q000737:chemistry / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D051381:Rats; D012545:Schiff Bases / Q000737:chemistry* / Q000494:pharmacology*; D016415:Sequence Alignment; D000637:Transaminases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*
C424693:7-ethylsalicylidenebenzylamine; D004791:Enzyme Inhibitors; D007527:Isoenzymes; D012545:Schiff Bases; D007737:Kynurenine; D000637:Transaminases; C021481:kynurenine-oxoglutarate transaminase