Cardioprotective effect of 'Marutham' a polyherbal formulation on isoproterenol induced myocardial infarction in Wistar rats.
Myocardial infarction is the number one killer disease in many parts of the world. The cardioprotective effect of Marutham, a polyherbal formulation on serum and heart tissue lipids, serum lipoproteins and heart membrane bound enzymes in isoproterenol induced myocardial infarction was studied in Wistar rats. Pretreatment with Marutham at different doses of 30, 60 and 90 mg kg(-1) to isoproterenol treated rats significantly prevented the altered lipid profile and membrane bound enzymes to near normal status. The results of our study showed the cardioprotective potential of Marutham on isoproterenol induced myocardial infarction in rats.
Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar-608 002, Tamil Nadu, India. ps_mainzenprince@yahoo.co.in
Ponnian Stanely Mainzen
PS
Prince
Selvaraju
S
Suman
Periyathambi Thangappan
PT
Devika
Muthukumarasamy
M
Vaithianathan
D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000188:drug therapy*; D007545:Isoproterenol; D008055:Lipids / Q000032:analysis / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008565:Membrane Proteins / Q000187:drug effects; D009203:Myocardial Infarction / Q000139:chemically induced / Q000188:drug therapy*; D009206:Myocardium / Q000201:enzymology; D008517:Phytotherapy; D053147:Plant Exudates / Q000008:administration & dosage / Q000627:therapeutic use*; D028321:Plant Preparations / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D002316:Cardiotonic Agents; D008055:Lipids; D008074:Lipoproteins; D008565:Membrane Proteins; D053147:Plant Exudates; D028321:Plant Preparations; D007545:Isoproterenol