RNASET2 as a tumor antagonizing gene in a melanoma cancer model.
The RNASET2 gene, mapped in 6q27, was previously found to exert control of tumorigenesis in an ovarian cancer system. We present here results indicating a similar control in a melanoma cancer model. Thus, this gene is most likely involved in a common general pathway of tumorigenesis. Moreover, its antitumorigenic activity is manifested in vivo but not in vitro, suggesting that this gene belongs to the growing category of tumor antagonizing/malignancy suppressor genes. A possible role of RNASET2 in the activation of a senescence program, whose responsible locus was mapped in the same chromosomal 6q27 region, seems to be inconsistent with our data.
Monti
Laura
L
Department of Biotechnology and Molecular Sciences, University of Insubria, Varese, Italy.
Rodolfo
Monica
M
Rudolfo
Monica
M
Lo Russo
Girieca
G
Noonan
Douglas
D
Acquati
Francesco
F
Taramelli
Roberto
R
D000818:Animals; D015152:Blotting, Northern; D049109:Cell Proliferation; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D004195:Disease Models, Animal; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D015316:Genetic Therapy; D006801:Humans; D008546:Melanoma, Experimental / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008819:Mice, Nude; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012260:Ribonucleases / Q000235:genetics*; D014407:Tumor Cells, Cultured; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D023041:Xenograft Model Antitumor Assays
D012333:RNA, Messenger; D025521:Tumor Suppressor Proteins; D012260:Ribonucleases; C425232:RNASET2 protein, human