Role of the gp85/trans-sialidase superfamily of glycoproteins in the interaction of Trypanosoma cruzi with host structures.
Invasion of mammalian cells by T. cruzi trypomastigotes is a multi-step and complex process involving several adhesion molecules, signaling events and proteolytic activities. From the blood to the cell target in different tissues the parasite has to interact with different cells and the extracellular matrix (ECM). The review focus on the role of the gp85/ trans-sialidase superfamily members in the interaction of the parasite with the host cell, particularly with ECM components, with emphasis on the significant variability among the ligands and receptors involved. Use of the SELEX technique to evolve nuclease-resistant RNA aptamers for receptor identification is briefly discussed.
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, 05508-900 São Paulo, Brazil. mjmalves@iq.usp.br
Maria Júlia M
MJ
Alves
Walter
W
Colli
D000818:Animals; D052158:Aptamers, Peptide / Q000737:chemistry; D002448:Cell Adhesion / Q000502:physiology; D006023:Glycoproteins / Q000378:metabolism*; D006790:Host-Parasite Interactions; D006801:Humans; D008954:Models, Biological; D009439:Neuraminidase / Q000378:metabolism*; D052156:SELEX Aptamer Technique; D014349:Trypanosoma cruzi / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology*
D052158:Aptamers, Peptide; D006023:Glycoproteins; C069715:trans-sialidase; D009439:Neuraminidase