Direct arylation of oxazoles at C2. A concise approach to consecutively linked oxazoles.
The synthesis of bis- and trisoxazoles via direct arylation is discussed. A variety of aryl groups can be installed at the 2-position of 5-aryl and 5-carboxy-substituted oxazoles under mild conditions using palladium catalysis on water. The direct arylation method can be extended to the synthesis of bis- and trisoxazoles if 2-triisopropylsilyl-4-iodooxazole is used as the electrophile in the arylation.
University of Edinburgh, School of Chemistry, Joseph Black Building, King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, UK.
Emmanuel Ferrer
EF
Flegeau
Matthew E
ME
Popkin
Michael F
MF
Greaney
D001688:Biological Products / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry; D017613:Iodine Compounds / Q000737:chemistry; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*
D001688:Biological Products; D003432:Cross-Linking Reagents; D017613:Iodine Compounds; D010080:Oxazoles; D002244:Carbon; D007455:Iodine