Association of cannabis use with prodromal symptoms of psychosis in adolescence.
Recent interest has focused on the association between cannabis use and risk of psychosis. In the largest unselected, population-based study on this topic to date, we examined cannabis use and prodromal symptoms of psychosis at age 15-16 years among 6330 adolescents. Those who had tried cannabis (n=352; 5.6% of the total sample) were more likely to present three or more prodromal symptoms even after controlling for confounders including previous behavioural symptoms (OR=2.23; 95% CI 1.70-2.94). A dose-response effect was seen. We conclude that cannabis use is associated with prodromal symptoms of psychosis in adolescence.
Miettunen
Jouko
J
Department of Psychiatry, University of Oulu, PO Box 5000, 90014 University of Oulu, Finland. jouko.miettunen@oulu.fi
Törmänen
Sari
S
Murray
Graham K
GK
Jones
Peter B
PB
Mäki
Pirjo
P
Ebeling
Hanna
H
Moilanen
Irma
I
Taanila
Anja
A
Heinimaa
Markus
M
Joukamaa
Matti
M
Veijola
Juha
J
D000293:Adolescent; D002648:Child; D015331:Cohort Studies; D015986:Confounding Factors, Epidemiologic; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D008385:Marijuana Smoking / Q000009:adverse effects / Q000453:epidemiology / Q000523:psychology*; D011618:Psychotic Disorders / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors