Tuneable pseudorotaxane formation between a biotin-avidin bioconjugate and CBPQT4+.
A biotinylated 1,5-dialkoxynaphthalene derivative has been shown to have the ability to bind strongly to avidin and thus act as an artificial binding site for cyclobis(paraquat-p-phenylene) thereby facilitating the formation of a tuneable pseudorotaxane-based bioconjugate.
Glasgow Centre for Physical Organic Chemistry, WestCHEM, Department of Chemistry, Joseph Black Building, University of Glasgow, Glasgow, UK G12 8QQ.
Stuart T
ST
Caldwell
Graeme
G
Cooke
Alan
A
Cooper
Margaret
M
Nutley
Gouher
G
Rabani
Vincent
V
Rotello
Brian O
BO
Smith
Patrice
P
Woisel
D001360:Avidin / Q000737:chemistry*; D001665:Binding Sites; D001710:Biotin / Q000737:chemistry*; D004583:Electrons; D008956:Models, Chemical; D009281:Naphthalenes / Q000737:chemistry*; D010269:Paraquat / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D043862:Rotaxanes / Q000138:chemical synthesis*; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors
D009281:Naphthalenes; D043862:Rotaxanes; D001360:Avidin; D001710:Biotin; D010269:Paraquat