Cembrane diterpenoids from the taiwanese soft coral Sarcophyton stolidotum.
Investigation of an EtOAc-soluble extract of the soft coral Sarcophyton stolidotum resulted in the isolation of seven new 14-membered carbocyclic cembranes, sarcostolides A-G (1-7), together with two known cembrane diterpenes, isosarcophytoxide and isosarcophine. The structural elucidation of these metabolites was determined on the basis of spectroscopic analyses, particularly 2D NMR techniques. Sarcostolide E (5) exhibited weak to moderate cytotoxic activity against human WiDr and Daoy tumor cell lines. A biogenetic pathway and relationship for compounds 1-7 was also proposed.
Institute of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.
Yuan-Bin
YB
Cheng
Ya-Ching
YC
Shen
Yao-Haur
YH
Kuo
Ashraf Taha
AT
Khalil
D000818:Animals; D037421:Anthozoa / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013624:Taiwan
D000970:Antineoplastic Agents; D004224:Diterpenes; C531342:sarcostolide E