A mouse plasma peptide atlas as a resource for disease proteomics.
We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis.
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. qing@fhcrc.org
Qing
Q
Zhang
Rajasree
R
Menon
Eric W
EW
Deutsch
Sharon J
SJ
Pitteri
Vitor M
VM
Faca
Hong
H
Wang
Lisa F
LF
Newcomb
Ronald A
RA
Depinho
Nabeel
N
Bardeesy
Daniela
D
Dinulescu
Kenneth E
KE
Hung
Raju
R
Kucherlapati
Tyler
T
Jacks
Katerina
K
Politi
Ruedi
R
Aebersold
Gilbert S
GS
Omenn
David J
DJ
States
Samir M
SM
Hanash
D017398:Alternative Splicing; D000818:Animals; D030562:Databases, Protein; D006801:Humans; D051379:Mice; D010455:Peptides / Q000032:analysis*; D010949:Plasma / Q000737:chemistry*; D020033:Protein Isoforms; D040901:Proteomics; D053719:Tandem Mass Spectrometry
D010455:Peptides; D020033:Protein Isoforms