Association of endothelial protein C receptor haplotypes, factor V Leiden and recurrent first trimester pregnancy loss.
OBJECTIVE
We evaluated whether the endothelial protein C receptor (EPCR) haplotypes A1 and A3 exert effects on the development of recurrent pregnancy loss (RPL) in association with factor V Leiden.


METHODS
We determined the EPCR haplotypes A1 and A3 and factor V Leiden in 49 women with a history of RPL and 48 parous controls.


RESULTS
In carriers of factor V Leiden the A1 haplotype decreased the relative risk for RPL from 2.2 to 1.0.


CONCLUSIONS
The EPCR A1 haplotype tends to modulate the risk for RPL in carriers of factor V Leiden.
Department of Laboratory Medicine, Rudolfstiftung Hospital, Vienna, Austria.
Pierre
P
Hopmeier
Helene
H
Puehringer
Mick
M
van Trotsenburg
Johanna
J
Atamaniuk
Christian
C
Oberkanins
Astrid
A
Dossenbach-Glaninger
D000026:Abortion, Habitual / Q000235:genetics*; D015703:Antigens, CD / Q000235:genetics*; D004247:DNA / Q000235:genetics; D000074283:Endothelial Protein C Receptor; D005165:Factor V / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011956:Receptors, Cell Surface / Q000235:genetics*; D012307:Risk Factors
D015703:Antigens, CD; D000074283:Endothelial Protein C Receptor; C478370:PROCR protein, human; D011956:Receptors, Cell Surface; C095381:factor V Leiden; D005165:Factor V; D004247:DNA