Integrins in prostate cancer progression.
Integrins, which are transmembrane receptors for extracellular matrix proteins, play a key role in cell survival, proliferation, migration, gene expression, and activation of growth factor receptors. Their functions and expression are deregulated in several types of cancer, including prostate cancer. In this article, we review the role of integrins in prostate cancer progression and their potential as therapeutic targets.
Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Hira Lal
HL
Goel
Jing
J
Li
Sophia
S
Kogan
Lucia R
LR
Languino
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016023:Integrins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000502:physiology; D008297:Male; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic / Q000235:genetics; D011471:Prostatic Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000473:pathology; D047368:Tumor Burden / Q000235:genetics
D000970:Antineoplastic Agents; D016023:Integrins