Circulating nucleic acids in plasma and serum: roles in diagnosis and prognosis in diabetes and cancer.
The presence of DNA and RNA circulating in human plasma and serum is described. The possible sources of the DNA/RNA in blood, their ability to enter other cells and to express in the recipient cells are discussed and the relationship with metastases considered. The possible role(s) of the DNA/RNA in clinical diagnosis, in monitoring treatment and in prognosis are considered for diabetes and oncology.
Gahan
Peter B
PB
Anatomy & Human Sciences, King's College London, London Bridge, London SE1 1UL, UK. pgahan@aol.com
D015415:Biomarkers / Q000097:blood; D004247:DNA / Q000097:blood*; D004273:DNA, Neoplasm / Q000097:blood; D048909:Diabetes Complications / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D011379:Prognosis; D012313:RNA / Q000097:blood*; D012334:RNA, Neoplasm / Q000097:blood
D015415:Biomarkers; D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D012313:RNA; D004247:DNA