The effect of a three-tier formulary on antidepressant utilization and expenditures.
BACKGROUND
Health plans in the United States are struggling to contain rapid growth in their spending on medications. They have responded by implementing multi-tiered formularies, which label certain brand medications 'non-preferred' and require higher patient copayments for those medications. This multi-tier policy relies on patients' willingness to switch medications in response to copayment differentials. The antidepressant class has certain characteristics that may pose problems for implementation of three-tier formularies, such as differences in which medication works for which patient, and high rates of medication discontinuation.


OBJECTIVE
To measure the effect of a three-tier formulary on antidepressant utilization and spending, including decomposing spending allocations between patient and plan.


METHODS
We use claims and eligibility files for a large, mature nonprofit managed care organization that started introducing its three-tier formulary on January 1, 2000, with a staggered implementation across employer groups. The sample includes 109,686 individuals who were continuously enrolled members during the study period. We use a pretest-posttest quasi-experimental design that includes a comparison group, comprising members whose employer had not adopted three-tier as of March 1, 2000. This permits some control for potentially confounding changes that could have coincided with three-tier implementation.


RESULTS
For the antidepressants that became nonpreferred, prescriptions per enrollee decreased 11% in the three-tier group and increased 5% in the comparison group. The own-copay elasticity of demand for nonpreferred drugs can be approximated as -0.11. Difference-in-differences regression finds that the three-tier formulary slowed the growth in the probability of using antidepressants in the post-period, which was 0.3 percentage points lower than it would have been without three-tier. The three-tier formulary also increased out-of-pocket payments while reducing plan payments and total spending.


CONCLUSIONS
The results indicate that the plan enrollees were somewhat responsive to the changed incentives, shifting away from the drugs that became nonpreferred. However, the intervention also resulted in cost-shifting from plan to enrollees, indicating some price-inelasticity. The reduction in the proportion of enrollees filling any prescriptions contrasts with results of prior studies for non-psychotropic drug classes. Limitations include the possibility of confounding changes coinciding with three-tier implementation (if they affected the two groups differentially); restriction to continuous enrollees; and lack of data on rebates the plan paid to drug manufacturers.


CONCLUSIONS
The results of this study suggest that the impact of the three-tier formulary approach may be somewhat different for antidepressants than for some other classes.


CONCLUSIONS
Policymakers should monitor the effects of three-tier programs on utilization in psychotropic medication classes.


CONCLUSIONS
Future studies should seek to understand the reasons for patients' limited response to the change in incentives, perhaps using physician and/or patient surveys. Studies should also examine the effects of three-tier programs on patient adherence, quality of care, and clinical and economic outcomes.
Hodgkin
Dominic
D
Heller School, Brandeis University, Waltham MA 02454-9110, USA. hodgkin@brandeis.edu
Parks Thomas
Cindy
C
Simoni-Wastila
Linda
L
Ritter
Grant A
GA
Lee
Sue
S
D000928:Antidepressive Agents / Q000191:economics* / Q000627:therapeutic use; D017047:Cost Sharing / Q000191:economics*; D003863:Depression / Q000523:psychology; D016527:Drug Costs / Q000706:statistics & numerical data; D011307:Drug Prescriptions / Q000191:economics* / Q000706:statistics & numerical data; D004363:Drug Utilization / Q000191:economics; D005260:Female; D005569:Formularies as Topic; D006801:Humans; D007345:Insurance Claim Review / Q000191:economics / Q000706:statistics & numerical data; D016015:Logistic Models; D008297:Male; D008329:Managed Care Programs / Q000191:economics / Q000706:statistics & numerical data; D010349:Patient Compliance / Q000706:statistics & numerical data; D012052:Reimbursement, Incentive / Q000191:economics; D012107:Research Design; D014481:United States
D000928:Antidepressive Agents