Fungicidal activity of truncated analogues of dihydrosphingosine.
The minimal fungicidal concentration (MFC) of dihydrosphingosine (DHS), phytosphingosine (PHS), and five short-chain DHS derivatives was determined for Candida albicans and Candida glabrata. In this respect, a C15- and a C17-homologue of DHS showed a 2- to 10-fold decreased MFC as compared to native DHS (i.e. C18-DHS). DHS derivatives that were active, that is, comprising 12, 15, 17, or 18 carbon atoms, induced accumulation of reactive oxygen species (ROS) in C. albicans.
Thevissen
Karin
K
Centre of Microbial and Plant Genetics (CMPG), Katholieke Universiteit Leuven, Kasteelpark Arenberg 20, 3001 Heverlee, Belgium.
Hillaert
Ulrik
U
Meert
Els M K
EM
Chow
Kuen K
KK
Cammue
Bruno P A
BP
Van Calenbergh
Serge
S
François
Isabelle E J A
IE
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002176:Candida albicans / Q000378:metabolism; D041221:Candida glabrata / Q000378:metabolism; D002244:Carbon / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D006801:Humans; D008956:Models, Chemical; D008968:Molecular Conformation; D010100:Oxygen / Q000737:chemistry; D017382:Reactive Oxygen Species; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
D000935:Antifungal Agents; D017382:Reactive Oxygen Species; D002244:Carbon; C012491:phytosphingosine; D013110:Sphingosine; C005682:safingol; D010100:Oxygen