[Features of clinical course of combination chemotherapy for liver involvement in Hodgkin's disease].
Retrospective investigation was carried out of clinical course and effectiveness of therapy in 31 patients with primary hepatic involvement in Hodgkin's disease and 63 cases of hepatic lesions relating to dissemination of relapsing tumor. Clinical diagnosis of hepatic involvement ought to be made using at least two procedures, preferably liver scanning and computed tomography of the abdominal cavity. Special attention should be given to most likely cases of specific lesions of liver who had previously presented with intoxication symptoms and spleen and/or subphrenic lymph node involvement. Dissemination-related hepatic lesions were among the most frequent (78%) in patients with primary tumor while focal and diffuse liver involvement was limited to 71% of cases of dissemination of relapsing tumor. MOPP, ABVD and BEACOPP regimes should be given preference in dealing with primary Hodgkin's disease. The latter procedure should predominate in cases of initial extended involvement or as second-line chemotherapy designed to defeat drug resistance and improve end results.
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D011379:Prognosis; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D014747:Vinblastine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D001761:Bleomycin; D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D014747:Vinblastine; D005047:Etoposide; D003606:Dacarbazine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone