Pulmonary paragonimiasis with coincidental malignant mesothelioma.
A 72-year-old man patient was referred to our institution for evaluation and treatment of right pleural effusion. Eosinophilic pleural effusion and peripheral eosinophilia were identified during the course of hospitalization. Pulmonary paragonimiasis was confirmed by the presence of paragonimus-specific IgG antibodies for Paragonimus (P.) westermani and P. miyazakii in his serum. Although Praziquantel, a highly effective agent for the treatment of lung flukes was repeatedly administered, the pleural effusion did not subside and the patient's condition gradually deteriorated until his death due to circulatory insufficiency. Postmortem examination revealed malignant mesothelioma of the sarcomatous type encasing the right lung and heart. Cardiac involvement accompanied with old and recent-onset myocardial ischemic changes resulted in death of this patient. Here, we report a very rare case of malignant mesothelioma with a concomitant infection of parasitic lung fluke.
Yamazaki
Mariko
M
Department of Respiratory Medicine, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo. mariko@med.juntendo.ac.jp
Ohwada
Akihiko
A
Miyaji
Atsuko
A
Yamazaki
Hiroshi
H
Nara
Takeshi
T
Hirai
Syu
S
Fujii
Hiroaki
H
Uekusa
Toshimasa
T
Suzuki
Masaru
M
Iwase
Akihiko
A
Takahashi
Kazuhisa
K
D000368:Aged; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D000909:Antibodies, Helminth / Q000097:blood; D004802:Eosinophilia / Q000150:complications; D006338:Heart Neoplasms / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008171:Lung Diseases / Q000150:complications* / Q000175:diagnosis; D008174:Lung Diseases, Parasitic / Q000150:complications* / Q000188:drug therapy / Q000469:parasitology; D008297:Male; D008654:Mesothelioma / Q000150:complications* / Q000175:diagnosis; D010237:Paragonimiasis / Q000150:complications* / Q000188:drug therapy / Q000469:parasitology; D010238:Paragonimus / Q000276:immunology / Q000302:isolation & purification; D048492:Paragonimus westermani / Q000276:immunology / Q000302:isolation & purification; D010996:Pleural Effusion / Q000209:etiology; D011223:Praziquantel / Q000627:therapeutic use
D000871:Anthelmintics; D000909:Antibodies, Helminth; D011223:Praziquantel