Electrochemical oxidation of luteolin at a glassy carbon electrode and its application in pharmaceutical analysis.
Luteolin is a flavonoid reported to occur widely in many medicinal plants. The electrochemical behavior of luteolin was studied in phosphate buffer solution (PBS) of pH 4.0 at a glassy carbon electrode (GCE) by cyclic voltammetry (CV) and differential pulse voltammetric method (DPV). The results indicated the well-defined redox peak of luteolin which was involving two electrons and two protons was observed and the electrode process is adsorption-controlled. The charge transfer coefficient (alpha) was calculated as 0.66. The relationships between oxidation peak current and the concentration of luteolin are linear in the range of 1.0 x 10(-8) - 1.0 x 10(-6) M by DPV method. The detection limit had been estimated as 5.0 x 10(-9) M. The facile and rapid method has been successfully applied to the detection of luteolin in tablets.
Liu
Ailin
A
Department of Pharmaceutical Analysis of the Fujian Meidical University, Fuzhou, China. ailinliu@mail.fjmu.edu.cn
Zhang
Shaobo
S
Huang
Liying
L
Cao
Yangyuan
Y
Yao
Hong
H
Chen
Wei
W
Lin
Xinhua
X
D002626:Chemistry, Pharmaceutical; D004563:Electrochemistry; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D047311:Luteolin / Q000032:analysis / Q000737:chemistry*; D010084:Oxidation-Reduction; D019999:Pharmaceutical Solutions; D012015:Reference Standards; D015203:Reproducibility of Results; D013607:Tablets
D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D013607:Tablets; D047311:Luteolin