Genomic analysis of Newcastle disease virus strain NA-1 isolated from geese in China.
Newcastle disease virus (NDV) has been thought to infect only domestic avian species, with waterfowl such as geese either not being infected, even by virulent strains, or developing only in apparent infection. In 1997, a new infectious disease producing high morbidity and mortality among geese broke out in many provinces of China, which was caused by a serotype I avian paramyxovirus (APMV-1)--NDV. To investigate how NDV spreads between chickens and geese, the complete genome of one NDV strain isolated from a goose was cloned and analyzed. The results indicate that there is conservation in NDV structural genetic evolution but that there are also considerable differences between goose and chicken NDV strains. Separate patterns of NDV evolution exist among wild bird species. Meanwhile, there is evidence indicating that the goose NDV may have evolved from chicken NDV strain Herts/33. In addition, the possibility was investigated that this new strain of NDV may bind to different sialic acid receptor binding sites than the normal NDV strains that have been investigated so far. This might provide clues to the evolution of the goose NDV.
Xu
M
M
Laboratory of Important Pathogen and Loemia of Animal, College of Animal and Veterinary Science, Jilin University, Changchun, 130062, People's Republic of China. amingjlu@163.com
Chang
S
S
Ding
Z
Z
Gao
H-W
HW
Wan
J-Y
JY
Liu
W-S
WS
Liu
L-N
LN
Gao
Y
Y
Xu
J
J
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001715:Bird Diseases / Q000821:virology*; D002681:China; D017124:Conserved Sequence; D019143:Evolution, Molecular; D005777:Geese / Q000821:virology*; D016679:Genome, Viral; D008969:Molecular Sequence Data; D009522:Newcastle disease virus / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000502:physiology; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D053585:Virus Attachment
D012367:RNA, Viral; D011956:Receptors, Cell Surface; C092488:sialic acid receptor