Novel open-chain cytochalsins from the marine-derived fungus Spicaria elegans.
Six novel open-chain cytochalasins (1-6) and one known [12]-cytochalasin (7) have been isolated from the fermentation broth of a marine-derived fungus, Spicaria elegans. Cytochalasins Z10-Z15 (1-6) are the first reported cytochalasins that contain an open chain to date. The structures of these new compounds were elucidated by spectroscopic methods. The cytotoxic effects on P388, A-549, HL-60, and BEL-7402 cell lines of all compounds were evaluated by the MTT method.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, People's Republic of China.
Rui
R
Liu
Zhenjian
Z
Lin
Tianjiao
T
Zhu
Yuchun
Y
Fang
Qianqun
Q
Gu
Weiming
W
Zhu
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D003572:Cytochalasins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000737:chemistry*; D006801:Humans; D007941:Leukemia P388; D008386:Marine Biology; D051379:Mice; D015394:Molecular Structure
D000970:Antineoplastic Agents; D003572:Cytochalasins