Plasmodium falciparum shows transcriptional versatility within the human host.
In a recent study published in Nature, Daily et al. profiled parasite gene expression in Plasmodium falciparum infections and identified three in vivo 'states' based on parasite transcription patterns. Despite similar host clinical features, two states displayed highly divergent gene expression, whereas the third was found in individuals with increased inflammatory markers. These findings suggest that parasites exist in different physiological states in vivo, providing an important foundation for future studies investigating how these states might contribute to malaria pathogenesis and outcome.
Lovegrove
Fiona E
FE
McLaughlin-Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, MaRS Centre, Toronto ON, Canada.
Peña-Castillo
Lourdes
L
Liles
W Conrad
WC
Hughes
Timothy R
TR
Kain
Kevin C
KC
D000818:Animals; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D014644:Genetic Variation; D006801:Humans; D016778:Malaria, Falciparum / Q000469:parasitology*; D010963:Plasmodium falciparum / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D014158:Transcription, Genetic