Coexistence of amplitude and frequency modulations in intracellular calcium dynamics.
The complex dynamics of intracellular calcium regulates cellular responses to information encoded in extracellular signals. Here we study the encoding of these external signals in the context of the Li-Rinzel model. We show that by control of biophysical parameters the information can be encoded in amplitude modulation (AM), frequency modulation (FM), or mixed (AM and FM) modulation. We briefly discuss the possible implications of this role of information encoding for astrocytes.
School of Physics & Astronomy, Tel-Aviv University, 69978 Tel-Aviv, Israel.
Maurizio
M
De Pittà
Vladislav
V
Volman
Herbert
H
Levine
Giovanni
G
Pioggia
Danilo
D
De Rossi
Eshel
E
Ben-Jacob
D000162:Acoustics; D000818:Animals; D001253:Astrocytes / Q000166:cytology; D001703:Biophysics / Q000379:methods*; D002118:Calcium / Q000737:chemistry* / Q000378:metabolism; D002468:Cell Physiological Phenomena; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D018625:Microscopy, Atomic Force; D008956:Models, Chemical; D015233:Models, Statistical; D009991:Oscillometry / Q000379:methods*; D015398:Signal Transduction; D013997:Time Factors
D002118:Calcium