Antitumor activity of C-21 steroidal glycosides from Cynanchum auriculatum Royle ex Wight.
The antitumor activities of six C-21 steroidal glycosides isolated from the root tuber of Cynanchum auriculatum Royle ex Wight were performed according to a microculture tetrazolium (MTT) method on human tumor cell lines SMMC-7721, MCF-7 and Hela. Of these compounds, caudatin-2,6-dideoxy-3-O-methy-β-D-cymaropyranoside and caudatin were found to be of the highest effects against human tumor cell line SMMC-7721 with IC(50) values of 13.49 and 24.95 μM, respectively. Then the in vivo assay further showed that caudatin-2,6-dideoxy-3-O-methy-β-D-cymaropyranoside and caudatin significantly inhibited the growth of transplantable H(22) tumors in mice.
Peng
Yun-ru
YR
Center of Drug Metabolism and Pharmacokinetic, China Pharmaceutical University, Nanjing 210009, China.
Li
You-bin
YB
Liu
Xiao-dong
XD
Zhang
Jian-feng
JF
Duan
Jin-ao
JA
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D045744:Cell Line, Tumor; D031105:Cynanchum / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000494:pharmacology*; D013256:Steroids / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays
D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D012503:Saponins; D013256:Steroids; C570806:caudatin; C531052:caudatin-2,6-dideoxy-3-O-methylcymaropyranoside