Structures of two novel heterocyclics from Whitmania pigra.
Two new heterocyclics, named hirudonucleodisulfide A (1) and hirudonucleodisulfide B (2), were isolated from the dried material of Whitmania pigra Whitman. Their structures were elucidated by various spectroscopic means in combination with X-ray crystallographic analysis. A biological assay in vitro against anoxic injury demonstrated that 1 and 2 have moderately anti-anoxic activity with EC (50) values of 27.01 +/- 2.23 microg/mL and 19.54 +/- 1.53 microg/mL, respectively.
Institute of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
Yun-Feng
YF
Zheng
Xian-Feng
XF
Huang
Guo-Ping
GP
Peng
D000818:Animals; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D000860:Hypoxia / Q000188:drug therapy*; D007865:Leeches / Q000737:chemistry*; D015394:Molecular Structure
D006575:Heterocyclic Compounds, 3-Ring