Shooting the messenger: CULLIN' insulin signaling with Fbw8.
When phosphorylated by mTORC1/S6K, the insulin receptor substrate (IRS-1) is targeted for ubiquitination and proteasomal degradation. In a recent issue of Molecular Cell, Xu et al. reveal that the E3 ubiquitin-ligase CUL7/Fbw8 targets IRS-1 for degradation, thereby implicating this enzyme in the regulation of insulin signaling.
Mieulet
Virginie
V
Cancer Research UK Department of Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, United Kingdom.
Lamb
Richard F
RF
D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D044842:Cullin Proteins / Q000235:genetics / Q000378:metabolism*; D044783:F-Box Proteins / Q000378:metabolism*; D055504:Insulin Receptor Substrate Proteins; D051379:Mice; D008954:Models, Biological; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010766:Phosphorylation; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D017434:Protein Structure, Tertiary; D040901:Proteomics; D014157:Transcription Factors / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D054875:Ubiquitination
D048868:Adaptor Proteins, Signal Transducing; C519509:Crtc1 protein, mouse; C494817:Cul7 protein, mouse; D044842:Cullin Proteins; D044783:F-Box Proteins; C513332:Fbxw8 protein, mouse; D055504:Insulin Receptor Substrate Proteins; C526295:Irs1 protein, mouse; D014157:Transcription Factors; D044767:Ubiquitin-Protein Ligases; D019869:Phosphatidylinositol 3-Kinases; D046988:Proteasome Endopeptidase Complex