Gianotti-Crosti syndrome in two adult patients.
BACKGROUND
Gianotti-Crosti syndrome was first described in Italy by Gianotti in 1955. It is considered a benign, self-limited exanthem that occurs in younger children. Adult cases are rare.


OBJECTIVE
We report two cases of Gianotti-Crosti syndrome in a previously healthy 37-year old Asian and 21-year old Caucasian female.


RESULTS
Histopathological analysis of 4-mm punch biopsies from the upper extremity of both patients revealed an interstitial dermatitis with mild to moderate perivascular lymphocytic infiltrate and occasional scattered eosinophils in the superficial and mid-dermis. Clinicopathological correlation was consistent with Gianotti-Crosti syndrome.


CONCLUSIONS
Since both patients experienced significant pruritus, patient 1 was initially treated with a high potency topical corticosteroid followed by a two-week course of oral prednisone and patient 2 was treated with a potent topical corticosteroid. Both patients were asymptomatic at follow-up 3 to 4 weeks after their initial presentation.
Division of Dermatology and Cutaneous Sciences, University of Alberta, Edmonton, Alberta, Canada. patriciating@gmail.com
Patricia T
PT
Ting
Benjamin
B
Barankin
Marlene T
MT
Dytoc
D000169:Acrodermatitis / Q000175:diagnosis* / Q000188:drug therapy; D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002990:Clobetasol / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004643:Emollients / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D013577:Syndrome
D000893:Anti-Inflammatory Agents; D004643:Emollients; D005938:Glucocorticoids; D002990:Clobetasol