Mild, efficient Friedel-Crafts acylations from carboxylic acids using cyanuric chloride and AlCl3.
A mild method for Friedel-Crafts acylation with aromatic and aliphatic carboxylic acids using cyanuric chloride, pyridine, and AlCl(3) was developed. Both inter- and intramolecular acylations were achieved at room temperature in high yield and in very short reaction times.
Kangani
Cyrous O
CO
Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. cyrouskangani@gmail.com
Day
Billy W
BW
D000215:Acylation; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D015394:Molecular Structure; D013696:Temperature; D014227:Triazines / Q000737:chemistry*
D017607:Aluminum Compounds; D002264:Carboxylic Acids; D002712:Chlorides; D014227:Triazines; D000077410:Aluminum Chloride; C019309:cyanuric chloride