Extra-chromosomal elements and the evolution of cellular DNA replication machineries.
DNA replication is fundamental to the propagation of cellular life. Remarkably, the bacterial replication machinery is distinct from that used by archaea and eukaryotes. In this article, we discuss the role that lateral gene transfer by extra-chromosomal elements might have had in shaping the replication machinery and even modulating the manner in which host cellular genomes are replicated.
Adam T. McGeoch is at the MRC Cancer Cell Unit, Hutchison MRC Centre, Hills Road, Cambridge, CB2 0XZ, UK.
Adam T
AT
McGeoch
Stephen D
SD
Bell
D019843:Archaeal Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism; D005075:Biological Evolution; D002875:Chromosomes / Q000235:genetics*; D004261:DNA Replication; D005057:Eukaryotic Cells / Q000502:physiology; D019143:Evolution, Molecular; D022761:Gene Transfer, Horizontal / Q000235:genetics*; D005810:Multigene Family; D010802:Phylogeny; D018741:Replication Origin; D012093:Replicon
D019843:Archaeal Proteins; D001426:Bacterial Proteins