Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies.
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a multifunctional transcription factor with important regulatory roles in inflammation, cellular growth, differentiation, and apoptosis. PPARgamma is expressed in a variety of immune cells as well as in numerous leukemias and lymphomas. Here, we review recent studies that provide new insights into the mechanisms by which PPARgamma ligands influence hematological malignant cell growth, differentiation, and survival. Understanding the diverse properties of PPARgamma ligands is crucial for the development of new therapeutic approaches for hematological malignancies.
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Tatiana M
TM
Garcia-Bates
Geniece M
GM
Lehmann
Patricia J
PJ
Simpson-Haidaris
Steven H
SH
Bernstein
Patricia J
PJ
Sime
Richard P
RP
Phipps