[The association of IL-2 promoter polymorphisms with idiopathic dilated cardiomyopathy in Chinese Han population].
OBJECTIVE
To investigate whether -384T/G, -475A/T, and -631G/A polymorphisms in the interleukin-2(IL-2) gene promoter region are associated with idiopathic dilated cardiomyopathy(IDCM) in Southwestern Chinese Han population.


METHODS
Polymerase chain reaction and restriction fragment length polymorphism techniques were used to analyze single nucleotide polymorphisms of the IL-2 gene at positions -384, -475, and -631 in 109 IDCM patients and 210 unrelated healthy subjects in Han population of Southwestern China.


RESULTS
Compared to healthy controls, the frequency of TT and TG genotypes (0.9541 in patients vs. 0.8762 in controls, P was 0.042) and the T allele (0.7294 in patients vs. 0.6452 in controls, P was 0.039) at position -384, were significantly increased in IDCM patients, whereas no differences of genotype or allele frequencies were found between IDCM patient and healthy control groups at positions -475 and -631.


CONCLUSIONS
These data indicate the association of IL-2 gene single nucleotide polymorphisms with human IDCM. Additionally, the T allele of the IL-2 gene promoter at position -384 may increase the risk of developing IDCM.
Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 People's Republic of China.
Ping
P
Huang
Bin
B
Zhou
Lin
L
Zhang
Xing
X
Liu
Bin
B
Chen
Li
L
Rao
D000328:Adult; D000368:Aged; D044466:Asian People; D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*
D007376:Interleukin-2