[Preparation and properties of sustained-release pellets of glycyrrhizin effective components].
OBJECTIVE
To prepare the glycyrrhizin pellets by extrusion-spheronization, and optimize the formulation of sustained release pellets of glycyrrhizin effective components coated with mixed Eudragit RS 100 and Eudragit RL 100.


METHODS
The sustained-release pellets of glycyrrhizin were prepared by Glatt fluid bed technique. The ratio of Eudragit RS 100 to Eudragit RL 100 in the formulation was optimized. The factors that influence the drug release behaviors and their properties were evaluated.


RESULTS
The optimal coat for drug sustained-release was shown at the ratio of Eudragit RS 100 to Eudragit RL 100 of 4:1, the loading weight of copolymers of 5% and the plasticizer concentration of 15%. The curves of cumulative drug release were fit for Peppas and Higuchi equation.


CONCLUSIONS
The optimal sustained release of the glycyrrhizin effective component pellets is featured by adjusting the ratio of Eudragit RS 100 to Eudragit RL 100 and the loading weight of copolymers.
Center of Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Li-hua
LH
Chen
Yi
Y
Feng
De-Sheng
DS
Xu
Jun-Song
JS
Li
Liang
L
Zhang
Yi-Han
YH
Wang
D000180:Acrylic Resins / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D019695:Glycyrrhizic Acid / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods
D000180:Acrylic Resins; D004365:Drugs, Chinese Herbal; D011108:Polymers; C050528:Eudragit RS; C058665:Eudragit RL; D019695:Glycyrrhizic Acid