Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis.
OBJECTIVE
Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) has been reported to be impaired in patients with ulcerative colitis (UC), and activation of PPARgamma is proved to inhibit the intestinal inflammation. As Plo12Ala polymorphism in codon 12 of the PPARgamma gene may decrease the promoter activity, we investigated the influences of PPARgamma polymorphism on the risk of UC in Japanese population.


METHODS
The study recruited 118 patients with UC and 142 health controls. Plo12Ala polymorphisms of PPARgamma were detected by polymerase chain reaction based restricted fragment length polymorphism.


RESULTS
The frequency of Pro/Alo heterozygotes of PPARgamma gene in UC and control group was 4.2% and 4.9%, respectively. No significant difference was found between UC and control group (P=1.00, Fisher's exact test). Plo12Ala genotype of PPARgamma did not show significant association with UC risk (OR=0.85, 95%CI=0.26-2.76).


CONCLUSIONS
Our research suggests that Plo12Ala polymorphism of PPARgamma may not be associated with the risk of developing ulcerative colitis in Japanese population.
Wang
Fangyu
F
Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan. wangf65@yahoo.com
Tahara
Tomomitsu
T
Arisawa
Tomiyasu
T
Sakata
Mikijyu
M
Takahama
Kazuya
K
Watanabe
Makoto
M
Hirata
Ichiro
I
Nakano
Hiroshi
H
D000328:Adult; D003093:Colitis, Ulcerative / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic
D047495:PPAR gamma