Novel "anchor modification" of polymeric biomaterial surfaces by the utilization of cyclodextrin inclusion complex supramolecules.
In this article, a novel approach for the surface modification of polymeric biomaterials by the utilization of supramolecules was studied. The supramolecules selected were cyclodextrin inclusion complexes (CICs). The biomaterial selected for surface modification was plasticized poly (vinyl chloride) (PVC-P). Results indicate that when the CICs were blended into PVC-P, they tend to migrate and "anchor" on the surface to achieve a remarkable protein-resistant surface, with improved blood compatibility. In comparison with a physical mixture of cyclodextrins and a "guest" molecule, such as poly(ethylene oxide) (PEO)-poly(propylene oxide) (PPO)-PEO and PPO-PEO-PPO for PVC-P modification, CICs modified PVC-P are more consistent in processing and achieve reproducible surface characteristics. Based on this study, a novel "anchor modification" was proposed regarding CICs modified surface. This "anchor modification" is likely to reduce plasticizer extraction from PVC-P and also can be utilized for the modification of polymers other than PVC-P.
Bioengineering Unit, University of Strathclyde, Glasgow G4 0NW, United Kingdom. xiaobin.zhao@strath.ac.uk
Xiaobin
X
Zhao
James M
JM
Courtney
D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D005340:Fibrinogen / Q000737:chemistry; D008422:Materials Testing; D015394:Molecular Structure; D010968:Plasticizers / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011143:Polyvinyl Chloride / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013499:Surface Properties
D001672:Biocompatible Materials; D003505:Cyclodextrins; D010968:Plasticizers; D011108:Polymers; D005340:Fibrinogen; D011143:Polyvinyl Chloride