Intramedullary application of bone morphogenetic protein in the management of a major bone defect after an Ilizarov procedure.
We describe a patient with insufficient bone regeneration of the tibia after bone transport over an intramedullary nail, in whom union was ultimately achieved after exchange nailing and intramedullary application of rh-bone morphogenetic protein-7 at the site of distraction.
Department of Trauma Surgery, University Hospital Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany. burkhart@unfall.klinik.uni-mainz.de
K J
KJ
Burkhart
P M
PM
Rommens
D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000601:surgery; D002648:Child; D005260:Female; D015775:Fractures, Stress / Q000601:surgery; D006801:Humans; D018889:Ilizarov Technique; D007870:Leg Length Inequality / Q000601:surgery; D019857:Osteogenesis, Distraction; D011994:Recombinant Proteins / Q000627:therapeutic use; D012208:Rhabdomyosarcoma / Q000601:surgery; D013977:Tibia / Q000601:surgery*; D013978:Tibial Fractures / Q000601:surgery; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*
C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta