[Granular cell tumor of the larynx--literature review and case report].
Granular cell tumor (Abrikosov's tumor) of the larynx is a very uncommon lesion. Up to date, only about 200 cases have been reported. The exact origin of granular cell tumor is still unclear, however most authors believe it to be a neoplastic process derived from neuroectoderm. Immunohistochemical positive staining for S-100 protein is found in all cases. Complete resection of the lesion with an attempt to leave remaining laryngeal structures intact, generally results in total recovery. The majority of reported tumors were removed by microlaryngoscopy.


METHODS
63-year-old female presented 2-month-long history of increasing dysphonia. She had smoked 20 cigarettes a day for over 30 years. Indirect laryngoscopy disclosed oedematous mucosa in both vocal folds. No tumor was observed. Applying Kleinsasser procedure, a tumor 3 mm in diameter covered with normal mucosa was found growing in the posterior wall of the bottom of the right ventricle. The tumor as well as hypertrophic mucosa of the vocal folds were removed. Histopathological examination of the operative specimen revealed a granular cell tumor and chronic laryngitis. Immunohistochemically tumor cells were positive for S-100. The patient has been asymptomatic for 6 months.


CONCLUSIONS
Surgical removal of the laryngeal granular cell tumor with indications and extent of the resection like in benign tumors, was therapeutically efficient in the presented case.
Zagólski
Olaf
O
Oddział Otolaryngologiczny, Specjalistyczne Centrum Diagnostyczno-Zabiegowe-Medicina, Kraków. olafzag@poczta.onet.pl
Gajda
Mariusz
M
Czajecki
Krzysztof
K
D005260:Female; D016586:Granular Cell Tumor / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery*; D008875:Middle Aged