[Pharmacological significance of alpha lipoic acid in up to date treatment of diabetic neuropathy].
Alpha lipoic acid is important intramolecular redox system. It is coenzyme of piruvate dehydrogenase and ketoglutarate dehydrogenase. Alpha lipoic acid has enzymatic and cytoprotective effect. It has key role in citric acid cycle, as a coenzyme. Therapeutic efficacy of alpha lipoic acid in diabetic neuropathy is based on reaction with free radicals and lipophylic antioxydans properties. Clinical studies results showed efficacy and safety of alpha liponic acid application in patients with diabetic neuropathy.
Becić
Fahir
F
Institut za Farmakologiju, Klinicku farmakologiju i toksikologiju, Medicinski Fakultet u Sarajevu. fbecic@dic.unsa.ba
Kapić
Elvedina
E
Rakanović-Todić
Maida
M
D000975:Antioxidants / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D006801:Humans; D008063:Thioctic Acid / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D014803:Vitamin B Complex / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
D000975:Antioxidants; D014803:Vitamin B Complex; D008063:Thioctic Acid