Imaging of conformational changes of biotinylated triamide molecules covalently bonded to a carbon nanotube surface.
A diamide molecule bearing a biotin terminus was bonded via an amide linkage to the surface of an aminated single-walled carbon nanotube and examined by a high-resolution transmission electron microscope. The still and movie images allowed us to study not only the conformation of the molecule but also its time evolution. An iterative sequence of modeling and simulation allowed us to assign one plausible conformation out of >10(8) possibilities. The images also provide direct support for the accepted wisdom that the curved regions of pristine carbon nanotubes are chemically reactive.
Nakamura Functional Carbon Cluster Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. nakamura@chem.s.u-tokyo.ac.jp
Eiichi
E
Nakamura
Masanori
M
Koshino
Takatsugu
T
Tanaka
Yoshiko
Y
Niimi
Koji
K
Harano
Yuki
Y
Nakamura
Hiroyuki
H
Isobe
D000577:Amides / Q000737:chemistry*; D001710:Biotin / Q000737:chemistry*; D019921:Biotinylation; D046529:Microscopy, Electron, Transmission; D008968:Molecular Conformation; D015394:Molecular Structure; D037742:Nanotubes, Carbon / Q000737:chemistry*; D013499:Surface Properties
D000577:Amides; D037742:Nanotubes, Carbon; D001710:Biotin