Alpha-glucosidase inhibitor from Chinese aloes.
Activity-guided fractionation of the methanol extract of Chinese aloes led to the isolation of aloeresin A, which demonstrated significant dose dependent alpha-glucosidase inhibitory activities, with IC(50) values of 11.94 and 2.16 mM, against rat intestinal sucrase and maltase, respectively.
Laboratory of Food Biochemistry, Division of Applied Bioscience,Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan. j_nilubon@hotmail.com
Nilubon
N
Jong-Anurakkun
Megh Raj
MR
Bhandari
Gao
G
Hong
Jun
J
Kawabata
D000504:Aloe / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003920:Diabetes Mellitus / Q000188:drug therapy; D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D008517:Phytotherapy; D018515:Plant Leaves; D051381:Rats
D001786:Blood Glucose; D002867:Chromones; D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors; D005960:Glucosides; D065089:Glycoside Hydrolase Inhibitors; C521199:aloeresin A