Dendrimers and DNA: combinations of two special topologies for nanomaterials and biology.
Interactions between two precisely defined three-dimensional architectures (DNA and dendrimers) are described. Highly synergetic effects occur, as illustrated in two cases: dendrimers can be used as three-dimensional linkers for oligonucleotides, affording highly sensitive microarrays (biochips), and positively charged dendrimers strongly interact with DNA, allowing penetration inside cells (genetic transfection).
Caminade
Anne-Marie
AM
Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, Toulouse Cedex 4, France. caminade@lcc-toulouse.fr
Turrin
Cédric-Olivier
CO
Majoral
Jean-Pierre
JP
D000818:Animals; D001693:Biological Transport, Active; D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D050091:Dendrimers / Q000737:chemistry* / Q000378:metabolism; D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D020411:Oligonucleotide Array Sequence Analysis; D009841:Oligonucleotides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D050091:Dendrimers; D009841:Oligonucleotides; D004247:DNA