Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata.
The marine fireworm, Eurythoe complanata, is known as a dangerous animal for humans because it induces skin inflammation through its small setae. Here, the inflammation-inducing substance was successfully isolated from the whole body using a methanolic extraction, and the inflammatory activity was determined using a bioassay. The structure was spectroscopically revealed to be a trimethylammonium with an unsaturated carbon chain and was named complanine. Complanine enhanced PKC activity in combination with TPA in vitro. This may explain the molecular mechanism behind its inflammation-inducing activity.
Nakamura
Kazuhiko
K
Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan. k_nakamura@bio.keio.ac.jp
Tachikawa
Yu
Y
Kitamura
Makoto
M
Ohno
Osamu
O
Suganuma
Masami
M
Uemura
Daisuke
D
D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D000818:Animals; D004789:Enzyme Activation; D007249:Inflammation / Q000139:chemically induced*; D009682:Magnetic Resonance Spectroscopy; D011077:Polychaeta / Q000737:chemistry*; D011493:Protein Kinase C / Q000378:metabolism; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity
D000475:Alkenes; D000644:Quaternary Ammonium Compounds; C530576:complanine; D011493:Protein Kinase C