[The pathogenesis and regulation of autoimmunity].
The pathogenesis of autoimmunity has been studied extensively using animal models and genome-wide genetic analysis. Moreover, recent advance in the therapy for the autoimmune diseases using molecular-targeted drugs has provided us a lot of information in the pathogenesis of human autoimmune diseases. In this review, we overviewed the recent progress in the study of autoimmunity including central tolerance, regulatory cells and cytokines. Finally, we discuss the relationship of innate immunity and adoptive immunity in the context of autoimmunity.
Miyake
Sachiko
S
Department of Immunology, National Institute of Neuroscience, NCNP.
D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology
D016207:Cytokines