Clostridium difficile infection after total joint arthroplasty: who is at risk?
Clostridium difficile-associated diarrhea is a recognized postoperative complication. However, the exact risk factors for this condition after total joint arthroplasty (TJA) remain unknown. This case-controlled study intended to identify the predisposing factors for this condition. There were 16 cases of C difficile infections after 9880 TJA (0.16% incidence) between January 2001 and May 2006 at our institution. The cases were matched with 32 controls for month/year of surgery and surgeon. This study suggests that patients with deteriorated physical status or those who receive greater than one antibiotic after surgery are at a higher risk for developing C difficile-associated diarrhea after TJA.
Rothman Institute of Orthopaedics at Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Mark F
MF
Kurd
Luis
L
Pulido
Ashish
A
Joshi
James J
JJ
Purtill
Javad
J
Parvizi
D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D016022:Case-Control Studies; D016360:Clostridioides difficile; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006304:Health Status; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012307:Risk Factors
D000900:Anti-Bacterial Agents