Physical activity and progression of carotid intima-media thickness in patients with coronary heart disease.
OBJECTIVE
We conducted the present study to determine the level of physical activity required to retard the progression of carotid intima-media thickness (IMT) in patients with coronary heart disease (CHD).


METHODS
The daily walking distance (km/day) of 40 patients with CHD (male/female ratio: 37/3, mean age: 61.2 years, mean interval time after a coronary event 16.2 months) was examined. Carotid IMT examinations (B-mode ultrasonography) were performed at the baseline and after 6 months.


RESULTS
Among the patients, the average walking distance was 4.00km/day. Walking distance was inversely associated with IMT progression (r=-0.51, p<0.01). Multivariate logistic regression analysis revealed that walking distance (p=0.024) is a predictor for IMT progression independent of classical cardiovascular risk factors. Receiver operating characteristic analysis showed that the walking distance of 4.25km was strongly predictive of IMT preservation (sensitivity 64.0%, specificity 73.3%) in CHD patients.


CONCLUSIONS
Our data suggested that an increase in the daily walking distance could retard the progression of carotid IMT in patients with CHD. Cardiology medical staff should encourage their patients to expend an average of 4-5km in daily walking distance for the secondary prevention of cardiovascular disease.
Department of Rehabilitation Medicine, International Medical Center, Saitama Medical University, Hidaka-City, Saitama 350-1298, Japan. shinjisato2005hawaii@yahoo.co.jp
Shinji
S
Sato
Shigeru
S
Makita
Ryusei
R
Uchida
Shunich
S
Ishihara
Mitsuru
M
Majima
D000368:Aged; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D003327:Coronary Disease / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D012372:ROC Curve; D012044:Regression Analysis; D017539:Tunica Intima / Q000473:pathology*; D017540:Tunica Media / Q000473:pathology*; D014463:Ultrasonography; D016138:Walking