Endothelial Lipase: a key player in HDL metabolism modulates inflammation and atherosclerotic risk.
Endothelial Lipase (EL) is a newly identified member of the triacylglycerol lipase family. Recent studies suggested that EL may be an important determinant of HDL-metabolism and inflammation acting at the level of the vessel wall. The aim of this review is to summarize important facts derived from experimental approaches and from epidemiologic human studies to provide a comprehensive view on the role of EL in inflammation and atherogenesis as well as target for potential pharmaceutical interventions.
DeSantis
Pascual
P
Washington University in St. Louis, Department of Internal Medicine, St. Louis, MO 63110, USA.
Coleman
Trey
T
Schiekofer
Stephan
S
Nawroth
Peter P
PP
Schlimmer
Paul
P
Schneider
Jochen G
JG
D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology*; D004727:Endothelium / Q000201:enzymology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D008049:Lipase / Q000502:physiology*; D008075:Lipoproteins, HDL / Q000378:metabolism*; D012307:Risk Factors
D008075:Lipoproteins, HDL; D008049:Lipase