[Electrophysiological characteristics of depressive conditions with passive strategy of the adaptive behavior in rats].
Wistar rats strain with passive strategy of the adaptive behavior were selected in T-maze labyrinth. The rats were exposed to water-immerssions stress and after 10 days from their brain the olfactory cortex slices were prepared. The evoked focal potentials were registered in slices. It is shown that the amplitudes of the AMPA and NMDA EPSPs were reduced as compared to control (rats without stress). The amplitude of the GABABergic inhibitory postsynaptic potentiation was increased after stress. Additions of the corticotropin-releasing hormone (10(-10) M) in incubation medium result in reversible inhibition of synaptic transmission. Tetanic stimulation of the slices induced of the long-term posttetanic depression in 84 % slices and in 12 %--to the long-term posttetanic potentiation. It is indicates that the significant disturbances in synaptic transmission in slices. Thus the activation of the corticotrophinergic mechanisms in cortical structures not promots the removal of the rats depressive state with passive strategy of the adaptive behavior induced by inescapable stress.
Mokrushin
A A
AA
Khama-Murad
A Kh
AKh
Semenova
O G
OG
Shaliapina
V G
VG
D000222:Adaptation, Physiological; D000223:Adaptation, Psychological / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001522:Behavior, Animal / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D007101:Immersion / Q000503:physiopathology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D016202:N-Methylaspartate / Q000378:metabolism; D009833:Olfactory Pathways / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D013550:Swimming; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005680:gamma-Aminobutyric Acid; D016202:N-Methylaspartate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid