MRI-based separation of congenital and acquired vertebrobasilar artery anomalies in ischemic stroke of the posterior circulation.
OBJECTIVE
Stroke MRI protocols provide useful information about underlying vessel pathologies in the anterior circulation by means of intracranial time-of-flight angiography. However, these protocols mostly fail in the posterior circulation to differentiate between congenital variants and secondary thrombosis. Therefore, a high-resolution anatomic True Fast Imaging in Steady State Precession sequence, added to a commonly used stroke imaging protocol, was evaluated.


METHODS
MRIs of all emergency admissions to the stroke unit over 2 months were analyzed. Variations in the posterior circulation as displayed by time-of-flight and by the True Fast Imaging in Steady State Precession sequence, respectively, were graded by 2 readers blinded to the diagnosis.


RESULTS
In the time-of-flight angiography, 50% of patients presented with distinctive vertebrobasilar alterations. Half of these were judged as high-grade anomalies, of which the True Fast Imaging in Steady State Precession sequence identified 25% as hypoplasia. In 40% of all patients with posterior ischemia, the True Fast Imaging in Steady State Precession sequence confirmed an acquired occlusion of the vertebrobasilar arteries.


CONCLUSIONS
The addition of an anatomic (True Fast Imaging in Steady State Precession) to a functional sequence (time-of-flight) in stroke MRI protocols enables the differentiation between artery occlusions and hypoplastic variants of the vertebral arteries.
Wolfgang
W
Freund
Jan
J
Kassubek
Andrik J
AJ
Aschoff
Roman
R
Huber
D000368:Aged; D001488:Basilar Artery / Q000002:abnormalities / Q000473:pathology; D002533:Cerebral Angiography; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D020762:Infarction, Posterior Cerebral Artery / Q000473:pathology*; D018810:Magnetic Resonance Angiography; D008297:Male; D012189:Retrospective Studies; D014711:Vertebral Artery / Q000002:abnormalities / Q000473:pathology; D014715:Vertebrobasilar Insufficiency / Q000151:congenital* / Q000473:pathology*