[Interferon-alpha: a key cytokine in systemic lupus erythematosus pathogenesis].
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by a chronic inflammation affecting multiple tissues and the production of antibodies directed against nuclear antigens. Leading observations in patients suggested years ago that interferon-alpha (IFNalpha) was involved in SLE pathogenesis. These observations have now been confirmed in SLE-prone mice. New promising therapeutic strategies, aiming at neutralizing IFNalpha or its effects, are currently under development.
Mathian
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Service de médecine interne, centre de référence national pour les lupus et le syndrome des antiphospholipides, CHU Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 75651 Paris cedex 13, France. alexis.mathian@free.fr
Koutouzov
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S
D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects / Q000097:blood / Q000502:physiology*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000209:etiology / Q000276:immunology*
D016898:Interferon-alpha