Julius Axelrod: 20 May 1912 - 29 December 2004.
Julie Axelrod was a laboratory technician until the age of 42, when he finally achieved his PhD and independence. He worked at the National Institutes of Health for most of his career. Among his early pioneering research achievements in applying chemical and biochemical approaches to neuroscience were the discoveries of the painkiller acetaminophen (Tylenol, Paracetamol) and the liver microsomal drug-metabolizing enzymes, and the establishment of catechol-O-methyltransferase as an important enzyme in catecholamine metabolism. He shared the Nobel Prize in Physiology or Medicine in 1970 for his discovery that the reuptake of noradrenaline (norepinephrine) into the nerve endings from which it was released represented a novel method of neurotransmitter inactivation. An important corollary was the finding that antidepressant drugs acted as inhibitors of this uptake process. Subsequent work in his laboratory on the control of melatonin biosynthesis in the pineal gland provided new insights into the way in which the nervous system controls circadian rhythms, and offered an early model system in which to study the rapid control of mammalian gene expression. Axelrod continued actively in research until shortly before his death, and trained many students who have gone on to become leaders of the new field of biochemical neuropharmacology.
Iversen
Leslie
L
University of Oxford, Department of Pharmacology, Manfield Road, Oxford.
D000082:Acetaminophen / Q000266:history* / Q000493:pharmacokinetics; D049673:History, 20th Century; D049674:History, 21st Century; D008550:Melatonin / Q000266:history / Q000493:pharmacokinetics; D009316:National Institutes of Health (U.S.) / Q000266:history; D009613:Nobel Prize; D009638:Norepinephrine / Q000266:history / Q000378:metabolism / Q000493:pharmacokinetics / Q000502:physiology; D010870:Pineal Gland / Q000502:physiology; D012106:Research / Q000266:history; D014481:United States
D000082:Acetaminophen; D008550:Melatonin; D009638:Norepinephrine