Insular Alzheimer disease pathology and the psychometric correlates of mortality.
Right hemisphere dysfunction is associated with mortality in Alzheimer's disease (AD) and other neurologic conditions. These associations may be mediated by insular pathology, as insular lesions result in demonstrable changes in cardiovascular and autonomic control. AD affects the insulae at a preclinical stage, and insular AD pathology may be present in up to 40% of nondemented septuagenarians and octogenarians. This pathology can affect in vivo cardiac conduction and thereby dispose to cardiac arrhythmias and sudden death. Thus, AD pathology should be considered as a possible explanation for autonomic morbidity and mortality in nondemented elderly persons.
Royall
Donald R
DR
Department of Psychiatry, South Texas Veterans Health System Audie L. Murphy Division, Geriatric Research Education and Clinical Center, San Antonio, TX, USA. Royall@uthscsa.edu
D000544:Alzheimer Disease / Q000150:complications* / Q000401:mortality / Q000473:pathology; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000209:etiology* / Q000401:mortality; D001341:Autonomic Nervous System / Q000503:physiopathology; D002540:Cerebral Cortex / Q000473:pathology*; D016757:Death, Sudden, Cardiac / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D011379:Prognosis; D011594:Psychometrics; D012307:Risk Factors