Delusions and hallucinations in frontotemporal dementia: a clinicopathologic case report.
BACKGROUND
Frontotemporal dementia (FTD) is associated with marked behavior changes, but hallucinations and delusions are rare.


OBJECTIVE
To report a case of FTD with early and persistent delusions, including de Clerambault syndrome.


METHODS
We describe the clinical, neuroradiologic, and neuropathologic findings of a 76-year-old woman with an 11-year course of FTD with bizarre delusions and hallucinations.


RESULTS
The patient's autopsy examination of the brain revealed pathology consistent with frontotemporal lobar degeneration with ubiquitin-positive and transactive response (TAR)-DNA-binding protein-43-positive inclusions and hippocampal sclerosis.


CONCLUSIONS
Delusions and hallucinations can occur in proven frontotemporal pathology.
Department of Clinical Neurological Sciences, Division of Neurology, St Joseph's Hospital, University of Western Ontario, Ontario, Canada. mtartagl@uwo.ca
Maria Carmela
MC
Tartaglia
Andrew
A
Kertesz
Lee-Cyn
LC
Ang
D000368:Aged; D004268:DNA-Binding Proteins / Q000032:analysis; D003702:Delusions / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D003704:Dementia / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000473:pathology; D006212:Hallucinations / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D008297:Male; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000473:pathology / Q000523:psychology; D013702:Temporal Lobe / Q000473:pathology
D004268:DNA-Binding Proteins