[Antifungal cellobiose lipid secreted by the epiphytic yeast Pseudozyma graminicola].
The yeast Pseudozyma graminicola isolated from plants inhibited growth of almost all ascomycetes and basidiomycetes tested (over 270 species of ca. 100 genera) including pathogenic species. This yeast secreted a fungicidal agent, which was identified as a glycolipid composed of cellobiose residue with two O-substituents (acetyl and 3-hydroxycaproic acid) and 2,15,16-trihydroxypalmitic acid. The release of ATP from the glycolipid-treated cells indicated that this glycolipid impaired the permeability of the cytoplasmic membrane. Basidiomycetes were more sensitive to the cellobiose lipid than ascomycetes.
Golubev
V I
VI
Kulakovskaia
T V
TV
Shashkov
A S
AS
Kulakovskaia
E V
EV
Golubev
N V
NV
D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D001487:Basidiomycota / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002523:Edible Grain / Q000382:microbiology; D006017:Glycolipids / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D010539:Permeability / Q000187:drug effects; D015003:Yeasts / Q000302:isolation & purification / Q000378:metabolism*
D000935:Antifungal Agents; D006017:Glycolipids