Target selection: triage in the structural genomics battlefield.
A synopsis of some of the approaches to protein target selection is given, with an emphasis on using web resources to converge on well-ordered, readily crystallizable proteins that are maximally different from known structures. This is illustrated with the genomes of the pathogens causing tuberculosis and sleeping sickness.
Raftery
James
J
School of Chemistry, The University of Manchester, Manchester, UK.
D000818:Animals; D003460:Crystallization; D018360:Crystallography, X-Ray / Q000379:methods; D016208:Databases, Factual; D016680:Genome, Bacterial; D018503:Genome, Protozoan; D023281:Genomics / Q000379:methods*; D008958:Models, Molecular; D009161:Mycobacterium / Q000235:genetics; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D014347:Trypanosoma brucei gambiense / Q000235:genetics; D014353:Trypanosomiasis, African / Q000235:genetics; D014376:Tuberculosis / Q000235:genetics
D011506:Proteins