Putamen coactivation during motor task execution.
Models of corticostriatal motor circuitry have focused on the role of the circuit in the hemisphere of the motor cortex providing primary control (contralateral to the movement). We used functional magnetic resonance imaging and functional connectivity analyses to study circuit function in both the controlling and noncontrolling hemispheres. During the completion of a unilateral motor task with either hand, each putamen nucleus demonstrated strong coactivation with structures in both hemispheres. The putamen in the noncontrolling hemisphere (ipsilateral to the movement) coactivated more strongly with the controlling motor cortex than with the noncontrolling cortex. These findings suggest that the two corticostriatal circuits are functionally integrated. New circuit models based on functional connectivity may need to be developed.
Department of Veterans Affairs, VISN 19 MIRECC, Salt Lake City, Utah 84148, USA. william.marchand@va.gov
William R
WR
Marchand
James N
JN
Lee
John W
JW
Thatcher
Edward W
EW
Hsu
Esther
E
Rashkin
Yana
Y
Suchy
Gordon
G
Chelune
Jennifer
J
Starr
Sharon Steadman
SS
Barbera
D000328:Adult; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D011597:Psychomotor Performance / Q000502:physiology*; D011699:Putamen / Q000098:blood supply / Q000502:physiology*; D013647:Task Performance and Analysis
D010100:Oxygen