Transcriptome analysis of the Lactococcus lactis ArgR and AhrC regulons.
In previous studies, we have shown that direct protein-protein interaction between the two regulators ArgR and AhrC in Lactococcus lactis is required for arginine-dependent repression of the biosynthetic argC promoter and the activation of the catabolic arcA promoter. Here, we establish the global ArgR and AhrC regulons by transcriptome analyses and show that both regulators are dedicated to the control of arginine metabolism in L. lactis.
Larsen
Rasmus
R
Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, NL-9751 NN Haren, The Netherlands.
van Hijum
Sacha A F T
SA
Martinussen
Jan
J
Kuipers
Oscar P
OP
Kok
Jan
J
D001120:Arginine / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics*; D002151:Calorimetry; D020869:Gene Expression Profiling; D013294:Lactococcus lactis / Q000235:genetics*; D005810:Multigene Family; D020411:Oligonucleotide Array Sequence Analysis; D009876:Operon; D012097:Repressor Proteins / Q000235:genetics*; D014158:Transcription, Genetic
C087018:ArgR protein, Bacteria; D001426:Bacterial Proteins; D012097:Repressor Proteins; D001120:Arginine