Function and regulation of local axonal translation.
An increasing body of evidence indicates that local axonal translation is required for growing axons to respond appropriately to guidance cues and other stimuli. Recent studies suggest that asymmetrical synthesis of cytoskeletal proteins mediates growth cone turning and that local translation and retrograde transport of transcription factors mediate neuronal survival. Axonal translation is regulated partly by selective axonal localization of mRNAs and by translation initiation factors and RNA-binding proteins. We discuss possible rationales for local axonal translation, including distinct properties of nascent proteins, precise localization, and axonal autonomy.
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. al404@cam.ac.uk
Andrew C
AC
Lin
Christine E
CE
Holt
D000818:Animals; D001370:Axonal Transport / Q000235:genetics; D001369:Axons / Q000378:metabolism* / Q000648:ultrastructure; D002454:Cell Differentiation / Q000235:genetics; D002633:Chemotaxis / Q000235:genetics; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D009414:Nerve Growth Factors / Q000235:genetics / Q000378:metabolism*; D009420:Nervous System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
D009414:Nerve Growth Factors