Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis.
Porphyromonas gingivalis, a major periodontal pathogen, must acquire nutrients from host derived substrates, overcome oxidative stress and subvert the immune system. These activities can be coordinated via the gingipains which represent the most significant virulence factor produced by this organism. In the context of our contribution to this field, we will review the current understanding of gingipain biogenesis, glycosylation, and regulation, as well as discuss their role in oxidative stress resistance and apoptosis. We can postulate a model, in which gingipains may be part of the mechanism for P. gingivalis virulence.
Sheets
Shaun M
SM
Department of Biochemistry and Microbiology, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA.
Robles-Price
Antonette G
AG
McKenzie
Rachelle M E
RM
Casiano
Carlos A
CA
Fletcher
Hansel M
HM
D018829:Adhesins, Bacterial / Q000009:adverse effects* / Q000096:biosynthesis / Q000378:metabolism; D017209:Apoptosis; D001426:Bacterial Proteins / Q000378:metabolism; D016866:Bacteroidaceae Infections / Q000503:physiopathology*; D020169:Caspases / Q000378:metabolism; D003546:Cysteine Endopeptidases / Q000009:adverse effects* / Q000096:biosynthesis / Q000378:metabolism; D004260:DNA Repair; D005798:Genes, Bacterial; D000080867:Gingipain Cysteine Endopeptidases; D006031:Glycosylation; D006388:Hemagglutinins / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000382:microbiology / Q000503:physiopathology; D018384:Oxidative Stress; D016966:Porphyromonas gingivalis / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D014774:Virulence
D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; D000080867:Gingipain Cysteine Endopeptidases; D006388:Hemagglutinins; D017382:Reactive Oxygen Species; D020169:Caspases; D003546:Cysteine Endopeptidases