Cerebral metastases from malignant fibrous histiocytoma of bone.
Four patients with malignant fibrous histiocytoma of bone (MFH-B) metastasizing to brain are reported. In two cases, signs of cerebral involvement developed between 4 and 28 months after diagnosis. Both patients had known pulmonary or bony metastases. As a consequence of this experience, two further patients were subsequently identified, one with a definite cerebral metastasis and one who had an asymptomatic supratentorial lesion, possibly metastatic. It is suggested that patients with MFH-B and widespread metastatic disease at presentation or developing within a short interval should undergo cerebral imaging.
London Bone and Soft Tissue Tumour Service Meyerstein Institute of Oncology Middlesex Hospital Mortimer Street London W1N 8AA UK.
S J
SJ
Rogers
J S
JS
Whelan