Minimizing acquisition time of arterial spin labeling at 3T.
An improved arterial spin labeling (ASL) perfusion technique that combines pseudo-continuous labeling and a T2*-insensitive sequence (GRASE) with background suppression was used to acquire perfusion maps in normal volunteers and stroke patients. It is shown that perfusion measurements obtained in less than 1 min of scan time are reproducible, with a coefficient of variation of 7%. The perfusion maps generated from these data can be used to characterize the stroke lesion.
Fernández-Seara
María A
MA
Neuroimaging Laboratory, Center for Applied Medical Research, University of Navarra, Pamplona, Spain. mfseara@unav.es
Edlow
Brian L
BL
Hoang
Angela
A
Wang
Jiongjiong
J
Feinberg
David A
DA
Detre
John A
JA
D001783:Blood Flow Velocity; D002536:Cerebral Arteries / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels; D020521:Stroke / Q000503:physiopathology*
D013113:Spin Labels