The Hippocratic finger points the blame at PGE2.
Kenneth G
KG
Coggins
Thomas M
TM
Coffman
Beverly H
BH
Koller
D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D015232:Dinoprostone / Q000235:genetics*; D006801:Humans; D006911:Hydroxyprostaglandin Dehydrogenases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D009154:Mutation / Q000235:genetics*; D010004:Osteoarthropathy, Primary Hypertrophic / Q000201:enzymology / Q000235:genetics / Q000473:pathology
D006911:Hydroxyprostaglandin Dehydrogenases; C035859:15-hydroxyprostaglandin dehydrogenase; D015232:Dinoprostone