A bitter PP1 fights the sweet polo.
In a recent paper in Developmental Cell, Yamashiro et al. (2008) report that the PP1 regulatory subunit MYPT1 interacts with PLK1 and antagonizes essential mitotic functions of PLK1, at least in part by promoting the dephosphorylation of PLK1 at Thr210.
Department of Genetics, Cancer Research UK Cell Cycle Genetics Research Group, University of Cambridge, Downing Street, CB2 3EH Cambridge, UK. va228@cam.ac.uk
Vincent
V
Archambault
Feng
F
Chen
David M
DM
Glover
D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D008938:Mitosis / Q000235:genetics; D010766:Phosphorylation; D054645:Protein Phosphatase 1 / Q000737:chemistry* / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000097869:Polo-Like Kinase 1
D018797:Cell Cycle Proteins; D054645:Protein Phosphatase 1; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D000097869:Polo-Like Kinase 1