Numerical investigation of aerosol deposition at the eyes when using a hood inhaler for infants--a 3D simulation.
A numerical investigation of a hood inhaler is presented, aiming at the assessment of the amount of aerosol that reaches the eyes of the patient when administering medications with such a device. Using a hood for aerosol therapy for infants was already found to be effective and friendly to handle over the commonly used face mask. Using a hood device may adversely deliver unwanted medications to the eyes of the infant. The current study addresses the extent of aerosol deposition at the infant's eye zone. We describe the development and utilization of a numerical simulation for studying the transport and fate of the aerosol particles within a 3D realistic representation of the hood and the infant's head, with a focus on the eye zone. The governing equations were solved using the commercial software, FLUENT 6.1, which is based on the finite volume method. The computational domain was created using the GAMBIT package. The computational geometry was built separately for each configuration of the hood and the infant. It is shown that under optimal working conditions (i.e., when the infant's head is aligned to the funnel) the percentage of aerosol reaching the eye zone is 0.48%. However, when the funnel is tilted toward the eyes the amount of aerosol reaching the eyes zone is predicted to be 4.7%. In general, the results obtained in this study are in good agreement with available in vitro data. It can be concluded that using the hood for aerosol therapy results in minimal deposition at the infant's eye area.
Amirav
Israel
I
Pediatric Department, Ziv Medical Center, Safed and Faculty of Medicine, Technion, Haifa, Israel.
Shakked
Tal
T
Broday
David M
DM
Katoshevski
David
D
D000280:Administration, Inhalation; D000336:Aerosols / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D003198:Computer Simulation; D004867:Equipment Design; D005123:Eye / Q000378:metabolism*; D006801:Humans; D007223:Infant; D009330:Nebulizers and Vaporizers; D014018:Tissue Distribution
D000336:Aerosols