Synthesis, characterization, antioxidant activity and DNA-binding studies of three rare earth (III) complexes with 1-(4-aminoantipyrine)-3-tosylurea ligand.
1-(4-aminoantipyrine)-3-tosylurea (H2L) and its three lanthanide (III) complexes, M(H2L)3 3NO3 [where M=Nd(III), Sm(III) and Eu(III)], have been synthesized and characterized. In addition, the DNA-binding properties of the three complexes have been investigated by UV-vis (ultraviolet and visible) absorption spectroscopy, fluorescence spectroscopy, circular dichroism (CD) spectroscopy, cyclic voltammetry, and viscosity measurements. Results suggest that the three complexes bind to DNA via a groove binding mode. Furthermore, the antioxidant activity (superoxide and hydroxyl radical) of the metal complexes was determined by using spectrophotometer methods in vitro. These complexes were found to possess potent antioxidant activity and be better than standard antioxidants like vitamin C and mannitol.
Xi
Pin-xian
PX
State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Xu
Zhi-hong
ZH
Liu
Xiao-hui
XH
Chen
Feng-juan
FJ
Zeng
Zheng-zhi
ZZ
Zhang
Xiao-wen
XW
Liu
Ying
Y
D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000737:chemistry; D001665:Binding Sites; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004566:Electrodes; D017665:Hydroxyl Radical / Q000737:chemistry; D008024:Ligands; D008674:Metals, Rare Earth / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry; D014783:Viscosity
C540416:1-(4-aminoantipyrine)-3-tosylurea; D000975:Antioxidants; D008024:Ligands; D008674:Metals, Rare Earth; D009942:Organometallic Compounds; D017665:Hydroxyl Radical; D014508:Urea; D004247:DNA; D000983:Antipyrine