Deferoxamine induces endoplasmic reticulum stress in PC12 cells.
Deferoxamine (DFA, N'-[5-(acetyl-hydroxy-amino)-pentyl]-N-[5-[3-(5-aminopentyl-hydroxy-carbamoyl) propanoylamino]pentyl]-N-hydroxy-butane diamide) is a chelating agent used to remove excess iron from the body and to reduce organ and tissue damage. DFA enhances both iron regulatory protein 1 (IRP1) expression and its endoplasmic reticulum (ER) membrane-binding activity, as occurs in hypoxia, an ER stress, in cultured cells. Here, we show that DFA promotes ER stress via an ER signal pathway.
Yoo
Young-Bum
YB
Department of Surgery, College of Medicine, Konkuk University, Seoul 143-729, Korea.
Lee
Kyeong Ryong
KR
Kim
Seung-Whan
SW
Kwon
Kisang
K
Goo
Tae-Won
TW
Kwon
O-Yu
OY
D000818:Animals; D002460:Cell Line; D017931:DNA Primers; D003676:Deferoxamine / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000502:physiology*; D016716:PC12 Cells / Q000187:drug effects; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D017931:DNA Primers; D003676:Deferoxamine