Clinical practice experience with testosterone treatment in men with testosterone deficiency syndrome.
OBJECTIVE
To report on a clinical practice series of testosterone-replacement therapy (TRT) in men with testosterone deficiency syndrome (TDS), examining clinical efficacy, biochemical parameters and effects on prostate health over a 2-year period.


METHODS
A retrospective review of 85 patients with symptoms of TDS and at least a 3-month trial of TRT was performed in this single-centre, clinical practice setting. Three domains of symptomatology were evaluated: libido, erectile function and energy levels. Symptoms were assessed by a combination of patient reporting, physician's assessment and validated symptom assessment scores. Total testosterone (TT), calculated bio-available testosterone (BT) and prostate-specific antigen (PSA) levels were continuously measured and effects on prostate health were examined.


RESULTS
Only 38 (45%) patients in this cohort remained on TRT for >2 years. The most common reason for discontinuing treatment was lack of clinical response but those remaining on TRT had continued improvement in libido, erectile function and energy levels. During treatment, the average TT and calculated BT values significantly increased compared with the baseline values at most of the evaluated time points, with no significant change in average PSA values. In all, 15% of this cohort had some degree of progression of lower urinary tract symptoms. Seven patients had eight 'for-cause' prostate biopsies either during supplementation or at any date after completion, with an only three positive for cancer.


CONCLUSIONS
Only 45% of men on TRT remained on treatment for >2 years in this clinical practice experience of men with TDS. Those remaining showed persistent improvement in their symptoms. The average TT and BT values increased significantly with no significant change in PSA levels.
Department of Urology and Centre for Applied Urological Research, Kingston General Hospital, Queen's University, Kingston, ON, Canada.
Drew
D
McLaren
D Robert
DR
Siemens
Jason
J
Izard
Angela
A
Black
Alvaro
A
Morales
D000368:Aged; D000375:Aging / Q000502:physiology; D015331:Cohort Studies; D020249:Hormone Replacement Therapy; D006801:Humans; D007989:Libido / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010410:Penile Erection / Q000187:drug effects; D017430:Prostate-Specific Antigen / Q000378:metabolism*; D011788:Quality of Life; D012189:Retrospective Studies; D013577:Syndrome; D013739:Testosterone / Q000172:deficiency* / Q000627:therapeutic use*; D016896:Treatment Outcome
D013739:Testosterone; D017430:Prostate-Specific Antigen