Beneficial effects of Lagenaria siceraria (Mol.) Standley fruit epicarp in animal models.
Lagenaria siceraria (Mol.) Standley fruit (bottle gourd), a commonly used vegetable in India is described as cardiotonic and as a general tonic in Ayurveda. Keeping in view the presence of free radical scavenging activity in L. siceraria and involvement of free radicals in the development of various disorders, present studies were designed to evaluate the ethanolic extract of L. siceraria fruit against the disorders where free radicals play a major role in pathogenesis. The extract was found effective as hepatoprotective, antioxidant, antihyperglycemic, immunomodulatory, antihyperlipidemic and cardiotonic agent. The results showed that the radical scavenging capacity of L. siceraria fruit may be responsible for various biological activities studied.
Deshpande
J R
JR
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Amravati Road, Nagpur 440 010, India. jitendra_despande@rediffmail.com
Choudhari
A A
AA
Mishra
M R
MR
Meghre
V S
VS
Wadodkar
S G
SG
Dorle
A K
AK
D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002316:Cardiotonic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000378:metabolism; D019662:Cucurbitaceae / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism; D004195:Disease Models, Animal; D000431:Ethanol; D005260:Female; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D005609:Free Radicals / Q000378:metabolism; D005638:Fruit / Q000737:chemistry; D006339:Heart Rate / Q000187:drug effects; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D000960:Hypolipidemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D007111:Immunity, Cellular / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D011898:Ranidae; D051381:Rats; D017207:Rats, Sprague-Dawley
D000276:Adjuvants, Immunologic; D002316:Cardiotonic Agents; D016166:Free Radical Scavengers; D005609:Free Radicals; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D000431:Ethanol