MicroRNA regulation of messenger-like noncoding RNAs: a network of mutual microRNA control.
Metazoan microRNAs (miRNAs) are commonly encoded by primary mRNA-like characteristics (mlRNAs). To investigate whether mlRNAs are subject to miRNA control, we compared the expression of mlRNAs to that of tissue-specific miRNAs. We show that, like mRNAs, the expression levels of predicted mlRNA targets are significantly reduced in tissues where a targeting miRNA is expressed. On the basis of these results, we describe a potential network for posttranscriptional miRNA-miRNA control.
Bioinformatics Research Group, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China.
Yi
Y
Zhao
Shunmin
S
He
Changning
C
Liu
Songwei
S
Ru
Haitao
H
Zhao
Zhen
Z
Yang
Pengcheng
P
Yang
Xiongyin
X
Yuan
Shiwei
S
Sun
Dongbo
D
Bu
Jiefu
J
Huang
Geir
G
Skogerbø
Runsheng
R
Chen
D000818:Animals; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D035683:MicroRNAs / Q000235:genetics*; D009928:Organ Specificity / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated / Q000235:genetics*
D035683:MicroRNAs; D012333:RNA, Messenger; D022661:RNA, Untranslated