[Histopathologic pattern of hyperplasia of bone marrow hematogones (medullar b lymphoid cell precursors) occurring after treatment of idiopathic myelofibrosis].
Hematogones are bone marrow precursors of B-lymphoid cells which are morphologically difficult to distinguish from blasts and/or from small lymphocytes. We report the case of a patient presenting idiopathic myelofibrosis with minimal myeloid blastic transformation causing severe pancytopenia, treated by allograft and showing in a bone marrow biopsy, a hyperplasia of B-lymphoid cells. Histopathology and immunohistochemistry identified these cells as hyperplasia of hematogones and not a transformation into lymphoblastic acute leukaemia. The cytology of a myelogram confirmed the diagnosis.
Service d'anatomie pathologique, cliniques universitaires de Kinshasa, Kinshasa, République populaire du Congo.
Bienvenu Massamba
BM
Lebwaze
Agnès
A
Le Tourneau
Bernard
B
Rio
Jean-Yves
JY
Perrot
Laurence
L
Heuberger
Jean-Marie Mpolesha
JM
Kabongo
Raphaël Mbowa
RM
Kalengayi
Thierry
T
Molina
Jacques
J
Diebold
Josée
J
Audouin
D000328:Adult; D001402:B-Lymphocytes / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D006965:Hyperplasia / Q000473:pathology*; D007947:Leukemia, Megakaryoblastic, Acute / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D010198:Pancytopenia / Q000473:pathology; D055728:Primary Myelofibrosis / Q000473:pathology*