Chemokines in lupus nephritis.
Lupus nephritis is a common solid organ manifestation of systemic lupus erythematosus (SLE). The disease is tightly linked to the production of autoantibodies and circulating immune complexes, i.e. immune complex glomerulonephritis. In this process chemokines mediate multiple biological effects, e.g. orchestrating proinflammatory microenvironments, the recruitment of immune cell subsets into the kidney, as well as the local activation of such immune effector cells. Autoimmune mice with targeted deletions of certain single chemokines or chemokine receptors are protected from renal autoimmune tissue injury. Interventional studies with specific antagonists against certain chemokines and chemokine receptors further support these findings. In this review we summarise the available experimental and human data on the expression and functional role of chemokines and chemokine receptors in lupus nephritis.
Department of Nephrology, Medizinische Poliklinik, Klinikum der Universitat Munchen-Innenstadt, Munich, Germany.
Onkar
O
Kulkarni
Hans-Joachim
HJ
Anders
D000818:Animals; D018932:Chemokine CCL2 / Q000235:genetics; D018946:Chemokine CCL5 / Q000235:genetics; D018925:Chemokines / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use*; D015870:Gene Expression; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008181:Lupus Nephritis / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D023421:Models, Animal
C111835:CCL2 protein, human; D018932:Chemokine CCL2; D018946:Chemokine CCL5; D018925:Chemokines