Contribution of morphology discrimination algorithm for improving rhythm discrimination in slow and fast ventricular tachycardia zones in dual-chamber implantable cardioverter-defibrillators.
OBJECTIVE
Morphology discrimination (MD) is an algorithm based on QRS morphology analysis, that can be used alone or in various combinations with other discriminators in order to diagnose ventricular tachycardia (VT) [the implantable cardioverter-defibrillator (ICD) may be set to diagnose VT if 'Any' or 'All' the discriminators indicate VT)].


RESULTS
We evaluated the contribution of MD in terms of Specificity (SP) and Sensitivity (SE) of rhythm discrimination in slow and fast VT zones (rates <150 bpm and between 150 and 180 bpm, respectively). Detection results (682 spontaneous episodes in 58 patients) were corrected for multiple episodes within a patient (generalized estimating equations method). Rhythm discrimination in slow VT zones was characterized by SE and SP below 80% without MD, while the use of MD alone allowed to enhance SP, maintaining SE at 96%. Use of MD in combination with other discriminators resulted in a decrease in SP (setting 'Any'). In fast VT zones, MD allows an increase in SE for VT detection from around 82% up to approximately 94%, coupled with an SP of 95-96%., although SP is much higher with MD alone (94.8%) than with any other combination (78.4%). Both in slow and fast VT zones, use of multiple discriminators with the setting 'All' resulted in an unacceptable decrease in SE.


CONCLUSIONS
MD in a dual-chamber ICD in combination with a rate branch classification system makes it possible to achieve a very high SP in discriminating detected events both in slow and fast VT zones, while maintaining SE for VT detection.
Boriani
Giuseppe
G
Institute of Cardiology, University of Bologna, Azienda Ospedaliera S Orsola-Malpighi, Via Massarenti 9, 40138 Bologna, Italy. giuseppe.boriani@unibo.it
Occhetta
Eraldo
E
Cesario
Silvio
S
Grossi
Stefano
S
Marconi
Marco
M
Speca
Giancarlo
G
Silvestri
Paolo
P
Biffi
Mauro
M
Bortnik
Miriam
M
Martignani
Cristian
C
Branzi
Angelo
A
D000368:Aged; D000465:Algorithms; D017147:Defibrillators, Implantable; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D016002:Discriminant Analysis; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D010363:Pattern Recognition, Automated / Q000379:methods; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000517:prevention & control*; D013813:Therapy, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome