Cellular and molecular mechanisms of resistance to oral Candida albicans infections.
Oral candidiasis is a significant health problem in terms of both morbidity and economic outlay. Infections are predominantly caused by the commensal C. albicans, and affect immunocompromised individuals, including HIV-positive and AIDS patients, organ transplant recipients and chemotherapy patients. The molecular and cellular immune mechanisms involved in protection from and responses to oral candidiasis are overlapping, but distinct from those associated with other manifestations of the disease, including systemic, vaginal and gastric candidiasis. In oral candidiasis, clinical observations and experimental mouse models suggest a critical role for cell-mediated immunity. In mice, CD4+ T-cells and the p40 subunit of interleukins 12 and 23 are strict prerequisites for resistance; however abrogation of IFN-gamma does not confer susceptibility. Here, we discuss this apparent inconsistency, and review the experimental evidence that clarifies which immune pathways are specifically involved in resistance and responses to candidiasis of the oral cavity. We also highlight deficiencies in the literature, particularly concerning the putative roles of some relatively new elements in immunobiology: interleukin-23, interleukin-17 and T helper (Th)17 cells.
Oral Biology and Pathology, School of Dentistry, The University of Queensland, St Lucia, 4072, Australia.
Jodi Marie
JM
Saunus
Andrea
A
Kazoullis
Camile Selim
CS
Farah
D000938:Antigen-Presenting Cells / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002176:Candida albicans; D002180:Candidiasis, Oral / Q000276:immunology* / Q000503:physiopathology*; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D018664:Interleukin-12 / Q000276:immunology; D053759:Interleukin-23 / Q000276:immunology; D007962:Leukocytes / Q000502:physiology
D016207:Cytokines; D053759:Interleukin-23; D018664:Interleukin-12