[Orange-red light reduces the inhibition by UV-A of the proliferation of rat fibroblasts and influences their attachment in a dose-dependent fashion].
The effects of ultraviolet-A (UV-A, lambdam = 365 nm) and orange-red light (lambdam = 625 nm) on the attachment and proliferation of embryonic skin-muscle rat fibroblasts were investigated. It was found that orange-red light (ORL) produces both the stimulatory and inhibitory actions on the attachment and proliferation of fibroblasts, whereas UV-A radiation caused only the inhibition of the processes. Upon consecutive irradiation in both variants: ORL --> UV and UV --> ORL, the synergistic effect of the inhibitory action in both spectral regions was observed. Conversely, upon simultaneous irradiation with ORL (dose 3.6 J/cm2) and UV-A (dose 1.8 J/cm2), the inhibitory effect of ORL and UV-A weakened. Possible mechanisms of the effects are analyzed.
Khramov
R N
RN
Katkov
Iu A
IuA
Kreslavskiĭ
V D
VD
Murashev
A N
AN
Tsyganova
V G
VG
Simonova
N B
NB
Manokhin
A A
AA
D000818:Animals; D002448:Cell Adhesion / Q000528:radiation effects; D049109:Cell Proliferation / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000166:cytology / Q000528:radiation effects*; D066298:In Vitro Techniques; D018482:Muscle, Skeletal / Q000166:cytology; D051381:Rats; D011918:Rats, Inbred SHR; D012867:Skin / Q000166:cytology; D013472:Sunlight; D014466:Ultraviolet Rays