High-resolution ICP-MS determination of Ti, V, Cr, Co, Ni, and Mo in human blood and urine of patients implanted with a hip or knee prosthesis.
The main components (Ti, V, Cr, Co, Ni, and Mo) of metallic alloys currently used in hip and knee articular prostheses have been simultaneously determined in human whole blood and urine of implanted people by a (HR)-ICP-MS method previously developed in our laboratory. The determination of those elements has been carried out in patients with knee and hip prosthesis and in a group of pre-operation patients without any metallic device in their bodies, used as controls, demonstrating the usefulness of this technique to perform multielement analysis at ppt levels in complex matrices. The concentrations of V, Cr, Co, Ni, and Mo in urine and blood of implanted people turned out to be very similar to those obtained in control patients. However, raised Ti levels could be found both in urine and blood of patients with articular prostheses made or coated with a titanium alloy (Ti(6)Al(4)V).
Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Julián Clavería 8, 33006, Oviedo, Spain.
Alejandro
A
Sarmiento-González
Juan Manuel
JM
Marchante-Gayón
José María
JM
Tejerina-Lobo
José
J
Paz-Jiménez
Alfredo
A
Sanz-Medel
D000497:Alloys / Q000032:analysis / Q000493:pharmacokinetics; D002857:Chromium / Q000097:blood / Q000652:urine; D003035:Cobalt / Q000097:blood / Q000652:urine; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D013058:Mass Spectrometry / Q000379:methods*; D019216:Metals, Heavy / Q000032:analysis* / Q000097:blood / Q000652:urine; D008982:Molybdenum / Q000097:blood / Q000652:urine; D009532:Nickel / Q000097:blood / Q000652:urine; D014025:Titanium / Q000032:analysis* / Q000097:blood / Q000652:urine; D014639:Vanadium / Q000097:blood / Q000652:urine
D000497:Alloys; D019216:Metals, Heavy; D014639:Vanadium; D002857:Chromium; D003035:Cobalt; D009532:Nickel; D008982:Molybdenum; D014025:Titanium