Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury.
Inhalation of hydrogen (H(2)) gas has been demonstrated to limit the infarct volume of brain and liver by reducing ischemia-reperfusion injury in rodents. When translated into clinical practice, this therapy must be most frequently applied in the treatment of patients with acute myocardial infarction, since angioplastic recanalization of infarct-related occluded coronary artery is routinely performed. Therefore, we investigate whether H(2) gas confers cardioprotection against ischemia-reperfusion injury in rats. In isolated perfused hearts, H(2) gas enhances the recovery of left ventricular function following anoxia-reoxygenation. Inhaled H(2) gas is rapidly transported and can reach 'at risk' ischemic myocardium before coronary blood flow of the occluded infarct-related artery is reestablished. Inhalation of H(2) gas at incombustible levels during ischemia and reperfusion reduces infarct size without altering hemodynamic parameters, thereby preventing deleterious left ventricular remodeling. Thus, inhalation of H(2) gas is promising strategy to alleviate ischemia-reperfusion injury coincident with recanalization of coronary artery.
Division of Cardiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Kentaro
K
Hayashida
Motoaki
M
Sano
Ikuroh
I
Ohsawa
Ken
K
Shinmura
Kayoko
K
Tamaki
Kensuke
K
Kimura
Jin
J
Endo
Takaharu
T
Katayama
Akio
A
Kawamura
Shun
S
Kohsaka
Shinji
S
Makino
Shigeo
S
Ohta
Satoshi
S
Ogawa
Keiichi
K
Fukuda
D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D004195:Disease Models, Animal; D006859:Hydrogen / Q000008:administration & dosage* / Q000378:metabolism; D001239:Inhalation; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D020257:Ventricular Remodeling / Q000187:drug effects*
D002316:Cardiotonic Agents; D006859:Hydrogen