Recent progresses in protein-based chiral stationary phases for enantioseparations in liquid chromatography.
Chiral stationary phases (CSPs) based on proteins orglycoproteins have been developed for the enantioseparations of various compounds. In 2001, a review article [J. Haginaka, J. Chromatogr. A, 906 (2001) 253] dealing with CSPs based on proteins and glycoproteins was published. After that serum albumin from other species, penicillin G-acylase, antibodies, fatty acid binding protein and streptavidin were newly introduced as the chiral selectors in CSPs. This review article deals with recent progresses in CSPs based on protein or glycoproteins in LC after 2001, focusing on their enantioselective properties and chiral recognition mechanisms.
Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo 663-8179, Japan. haginaka@mukogawa-u.ac.jp
Jun
J
Haginaka
D000818:Animals; D002645:Chickens; D002853:Chromatography, Liquid / Q000295:instrumentation* / Q000379:methods*; D005087:Glucan 1,4-alpha-Glucosidase / Q000737:chemistry; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry; D008958:Models, Molecular; D009961:Orosomucoid / Q000737:chemistry; D010399:Penicillin Amidase / Q000737:chemistry; D010642:Phenoxyacetates / Q000737:chemistry; D010649:Phenylalanine / Q000302:isolation & purification; D012709:Serum Albumin / Q000737:chemistry; D013237:Stereoisomerism; D014443:Tyrosine / Q000302:isolation & purification
D007074:Immunoglobulin G; D009961:Orosomucoid; D010642:Phenoxyacetates; D012709:Serum Albumin; D014443:Tyrosine; D010649:Phenylalanine; D005087:Glucan 1,4-alpha-Glucosidase; D010399:Penicillin Amidase