[Studies on expectorant compounds in volatile oil from root and rhizome of Aster tataricus].
OBJECTIVE
To research the expectorant components in volatile oil from the root and rhizome of Aster tataricus.


METHODS
GC-MS was applied to isolate and identify the compounds. In addition, TLC was used to isolate compound, and its structure was elucidated on the basis of spectral data analysis. At the same time, its expectorant effect was observed by method of the excretion quantity of phenol red in trachea of mice.


RESULTS
Seven compounds were isolated and identified by GC-MS, they were (R)(-)-p-menth-1-en-4-ol (1), 2-undecanone (2), n-decanoic acid (3), (-)-spathulenol (4), hexahydrofamrnesyl acetone (5), hexadecanoic acid (6), and cis-9, cis-12-octaecadienoic acid (7). A known compound 1-acetoxy-2-ene(E)-4,6- decandiyne was isolated from the root and rhizome of A. tataricus, and it was shown to have expectorant effect.


CONCLUSIONS
1-Acetoxy-2-ene(E) -4,6- decandiyne, a main compound in volatile oil, had been found to have expectorant effect.
Yang
Bin
B
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. ybinmm@hotmail.com
Xiao
Yong-Qing
YQ
Liang
Ri-Xin
RX
Wang
Ruo-Jing
RJ
Li
Wen
W
Zhang
Cun
C
Cao
Ying
Y
Wang
Qian-Peng
QP
Wang
Lan
L
Wang
Yong-Yan
YY
D000818:Animals; D031173:Aster Plant / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005100:Expectorants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009822:Oils, Volatile / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D005100:Expectorants; D009822:Oils, Volatile