IgA nephropathy: markers of progression and clues to pathogenesis.
The unpredictable progression of IgA nephropathy hinders its treatment. The correlation of renal dysfunction with the immunophenotype of leukocytic infiltrates revealed interstitial CD20(+) cells and tubular NKG7(+)(GMP-17(+))/CD8(+) intraepithelial cells as predictive markers of progression in early-phase IgA nephropathy. This suggests that adaptive and innate immune responses mediate progression.
Department of Pathology, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA. Arifai@Lifespan.org
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D018951:Antigens, CD20 / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D018450:Disease Progression; D004848:Epithelium / Q000276:immunology / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate; D007684:Kidney Tubules / Q000276:immunology* / Q000473:pathology; D008565:Membrane Proteins / Q000032:analysis; D011379:Prognosis
D018951:Antigens, CD20; D015415:Biomarkers; D008565:Membrane Proteins; C499363:NKG7 protein, human