The effect of an experimental 4% Tif4 varnish compared to NaF varnishes and 4% TiF4 solution on dental erosion in vitro.
This in vitro study assessed the effect of an experimental 4% TiF(4) varnish compared to commercial NaF and NaF/CaF(2) varnishes and 4% TiF(4) solution on enamel erosion. For this, 72 bovine enamel specimens were randomly allocated to the following treatments: NaF varnish(2.26% F), NaF/CaF(2) varnish (5.63% F), 4% TiF(4) varnish (2.45% F), F-free placebo varnish, 4% TiF(4 )solution (2.45% F) and control (not treated). The varnishes were applied in a thin layer and removed after 6 h. The solution was applied to the enamel surface for 1 min. Then, the specimens were alternately de- and remineralized (6 times/day) in an artificial mouth for 5 days at 37 degrees C. Demineralization was performed with the beverage Sprite (1 min, 3 ml/min) and remineralization with artificial saliva (day: 59 min, 0.5 ml/min; during the night: 0.1 ml/min). The mean daily increment of erosion and the cumulative erosion data were tested using ANOVA and ANCOVA, respectively, followed by Tukey's test (alpha = 0.05). The mean daily erosion increments and cumulative erosion (micrometers) were significantly less for the TiF(4) varnish (0.30 +/- 0.11/0.65 +/- 0.75) than for the NaF varnish (0.58 +/- 0.11/1.47 +/- 1.07) or the NaF/CaF(2) varnish (0.62 +/- 0.10/1.68 +/- 1.17), which in turn showed significantly less erosion than the placebo varnish (0.78 +/- 0.12/2.05 +/- 1.43), TiF(4) solution (0.86 +/- 0.11/ 2.05 +/- 1.49) and control (0.77 +/- 0.16/2.06 +/- 1.49). In conclusion, the TiF(4) varnish seems to be a promising treatment to reduce enamel loss under mild erosive conditions.
Department of Child and Social Dentistry, School of Dentistry of Araçatuba, UNESP - São Paulo State University, Araçatuba, Brazil.
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Magalhães
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Kato
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Rios
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A
Wiegand
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Attin
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Buzalaf
D000704:Analysis of Variance; D000818:Animals; D002253:Carbonated Beverages; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D002417:Cattle; D003743:Dental Enamel / Q000187:drug effects*; D005460:Fluorides, Topical / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D006244:Hardness; D010895:Pit and Fissure Sealants / Q000737:chemistry* / Q000627:therapeutic use; D011897:Random Allocation; D012463:Saliva / Q000502:physiology; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000737:chemistry; D018709:Statistics, Nonparametric; D014025:Titanium / Q000008:administration & dosage / Q000737:chemistry; D017001:Tooth Demineralization / Q000139:chemically induced; D014077:Tooth Erosion / Q000517:prevention & control*; D014089:Tooth Remineralization
D002327:Cariostatic Agents; D005460:Fluorides, Topical; D010895:Pit and Fissure Sealants; D012969:Sodium Fluoride; D014025:Titanium