Impaired heart rate variability and altered cardiac sympathovagal balance after antidepressant overdose.
OBJECTIVE
Antidepressant overdose may be associated with significant cardiotoxicity, and recent data have shown that acute toxic effects are associated with impaired heart rate variability. This study was designed to examine the feasibility of non-invasive heart rate variability recording in patients that present to hospital after deliberate antidepressant ingestion.


METHODS
This was a prospective study of 72 consecutive patients attending the Emergency Department after deliberate antidepressant overdose and 72 age-matched patients that ingested paracetamol, as a control group. Single time-point continuous electrocardiographic recordings were used to allow spectral analyses of heart rate variability determined in low-frequency (LF) and high-frequency (HF) domains. The LF:HF ratio was used to represent overall sympathovagal cardiac activity.


RESULTS
Antidepressant overdose was associated with reduced overall heart rate variability: 1329 vs. 2018 ms(2) (P = 0.0239 by Mann-Whitney test). Variability in the LF domain was higher (64.8 vs. 49.8, P = 0.0006), whereas that in the HF domain was lower (24.3 vs. 36.4, P = 0.0001), and the LF:HF ratio was higher in the antidepressant group (2.4 vs. 1.2, P = 0.0003).


CONCLUSIONS
Antidepressant overdose is associated with impaired heart rate variability in a pattern consistent with excess cardiac sympathetic activity. Further work is required to establish the significance of these findings and to explore whether the impairment of heart rate variability may be used to predict the development of arrhythmia in this patient group.
Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, 51 Little France Crescent, EH164SA, Edinburgh, UK. s.waring@ed.ac.uk
W S
WS
Waring
J Y
JY
Rhee
D N
DN
Bateman
G E
GE
Leggett
H
H
Jamie
D000328:Adult; D000928:Antidepressive Agents / Q000506:poisoning*; D062787:Drug Overdose; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000294:innervation; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000503:physiopathology; D014630:Vagus Nerve / Q000187:drug effects* / Q000503:physiopathology
D000928:Antidepressive Agents