Effects of cognac on coronary flow reserve and plasma antioxidant status in healthy young men.
BACKGROUND
The cardioprotective effects of certain alcoholic beverages are partly related to their polyphenol content, which may improve the vasodilatory reactivity of arteries. Effect of cognac on coronary circulation, however, remains unknown. The purpose of this randomized controlled cross-over study was to determine whether moderate doses of cognac improve coronary reactivity as assessed with cold pressor testing (CPT) and coronary flow reserve (CFR) measurement.


METHODS
Study group consisted of 23 subjects. Coronary flow velocity and epicardial diameter was assessed using transthoracic echocardiography at rest, during CPT and adenosine infusion-derived CFR measurements before drinking, after a moderate (1.2 +/- 0.1 dl) and an escalating high dose (total amount 2.4 +/- 0.3 dl) of cognac. To explore the bioavailability of antioxidants, the antioxidant contents of cognac was measured and the absorption from the digestive tract was verified by plasma antioxidant capacity determination.


RESULTS
Serum alcohol levels increased to 1.2 +/- 0.2 per thousand and plasma antioxidant capacity from 301 +/- 43.9 micromol/l to 320 +/- 25.0 micromol/l by 7.6 +/- 11.8%, (p = 0.01) after high doses of cognac. There was no significant change in flow velocity during CPT after cognac ingestion compared to control day. CFR was 4.4 +/- 0.8, 4.1 +/- 0.9 (p = NS), and 4.5 +/- 1.2 (p = NS) before drinking and after moderate and high doses on cognac day, and 4.5 +/- 1.4, and 4.0 +/- 1.2 (p = NS) on control day.


CONCLUSIONS
Cognac increased plasma antioxidant capacity, but it had no effect on coronary circulation in healthy young men.


BACKGROUND
NCT00330213.
Kiviniemi
Tuomas O
TO
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. tuoski@utu.fi.
Saraste
Antti
A
Toikka
Jyri O
JO
Saraste
Markku
M
Raitakari
Olli T
OT
Pärkkä
Jussi P
JP
Lehtimäki
Terho
T
Hartiala
Jaakko J
JJ
Viikari
Jorma
J
Koskenvuo
Juha W
JW
D000328:Adult; D000428:Alcohol Drinking; D000434:Alcoholic Beverages; D000704:Analysis of Variance; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism*; D001783:Blood Flow Velocity / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000503:physiopathology*; D018592:Cross-Over Studies; D000431:Ethanol / Q000008:administration & dosage*; D005387:Finland; D006801:Humans; D008297:Male; D011336:Probability; D012016:Reference Values; D012680:Sensitivity and Specificity; D018617:Ultrasonography, Doppler, Pulsed; D014655:Vascular Resistance; D014664:Vasodilation / Q000187:drug effects*
D000975:Antioxidants; D000431:Ethanol