PCDD/F and PCB in human serum of differently exposed population groups of an Italian city.
A chemical plant located in Brescia, an industrial city in North-Western Italy, produced polychlorobiphenyls (PCBs) during a 30-50 year period, causing widespread pollution of the surrounding agricultural area. This area contains several small farms, which principally produce veal meat for private consumption of the farmers' families. The pollution went undiscovered for many years, during which period contaminated food was regularly consumed. This paper reports the polychlorodibenzodioxin (PCDD), polychlorodibenzofuran (PCDF) and PCB levels of a serum sample pooled from the consumers of contaminated food, compared to six population groups of the city of Brescia. Four of these groups were selected in order to represent, respectively, the local general population and the residents of three zones of the polluted area, while the last two groups represented, respectively, the present and the former workers of the plant. One human milk sample from one of the consumers of contaminated food was also analyzed. Results show that the consumers of the contaminated food and the former workers of the plant display considerably higher levels than all other groups. The levels of general population and of all other groups were generally similar both to each other and to the range of literature values for unexposed populations. The respective contribution of PCDDs, PCDFs, mono-ortho and non-ortho PCBs (dioxin-like PCBs) to (Toxicity Equivalents) TEQ of the population groups of this study were also compared to literature data: the two groups with a high contamination level, together with the human milk sample, displayed a higher incidence of mono-ortho PCBs and a lower contribution of PCDD, possibly correlated with the source of contamination.
Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. lturrio@iss.it
Luigi
L
Turrio-Baldassarri
Vittorio
V
Abate
Chiara Laura
CL
Battistelli
Sergio
S
Carasi
Marialuisa
M
Casella
Nicola
N
Iacovella
Annamaria
A
Indelicato
Cinzia
C
La Rocca
Carmelo
C
Scarcella
Silvia
S
Alivernini
D000368:Aged; D001572:Benzofurans / Q000097:blood*; D000072338:Dibenzofurans, Polychlorinated; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D005260:Female; D005506:Food Contamination; D006801:Humans; D007558:Italy; D008297:Male; D008420:Manufactured Materials / Q000633:toxicity; D008875:Middle Aged; D016273:Occupational Exposure / Q000706:statistics & numerical data; D011078:Polychlorinated Biphenyls / Q000097:blood*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000097:blood; D044382:Population Groups / Q000706:statistics & numerical data*
D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls