Genotoxic effects of arsenic: prevention by functional food-jaggery.
Arsenic contamination in groundwater is global human health hazard. There is no effective remedial action of chronic arsenicosis, however, a well-nourished diet can modulate the onset of adverse health effects and the delayed effect of arsenic in drinking water. In the present work, genotoxic effects induced by arsenic through parenteral administration and ameliorate by jaggery. Chromosomal aberrations were more pronounced in arsenic treated mice, while supplementation of jaggery with arsenic reduced the incidence of the aberrations. The outcome of study showed that Jaggery the natural functional food has the efficiency to encounter the genotoxic effects induced by arsenic.
Preventive Toxicology Division, Industrial Toxicology Research Centre, MG Marg, Lucknow, UP, India.
Nrashant
N
Singh
D
D
Kumar
S
S
Raisuddin
Anand P
AP
Sahu
D000818:Animals; D001151:Arsenic / Q000633:toxicity; D002869:Chromosome Aberrations; D051379:Mice; D018384:Oxidative Stress; D010936:Plant Extracts / Q000627:therapeutic use*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
C060188:Gur; D010936:Plant Extracts; D014874:Water Pollutants, Chemical; D001151:Arsenic