Statistical thermodynamics of the stability of multivalent ligand-receptor complexes.
Multivalent ligands can form ligand-receptor complexes that are orders of magnitude more stable than their monovalent counterparts. A theory of this "enhancement effect" based on fundamental principles of statistical thermodynamics is presented. A key finding is a simple analytical expression that provides clear and direct insight into the mechanism by which the enhanced stability of the multivalent ligand-receptor complex can be achieved. The theory explains experimental data on the activation of ion channels in the membranes of cells by polymer-linked divalent ligands.
Diestler
D J
DJ
Department of Biology, Chemistry and Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 6, D-14195 Berlin, Germany.
Knapp
E W
EW
D007700:Kinetics; D008024:Ligands; D008956:Models, Chemical; D008968:Molecular Conformation; D011956:Receptors, Cell Surface / Q000737:chemistry*; D013816:Thermodynamics
D008024:Ligands; D011956:Receptors, Cell Surface