Genetic basis of ventricular arrhythmias.
Sudden cardiac death caused by malignant ventricular arrhythmias is the most important cause of death in the industrialized world. Most of these lethal arrhythmias occur in the setting of ischemic heart disease. A significant number of sudden deaths, especially in young individuals, are caused by inherited ventricular arrhythmic disorders, however. Genetically induced ventricular arrhythmias can be divided in two subgroups: the primary electrical disorders or channelopathies, and the secondary arrhythmogenic cardiomyopathies. This article focuses on the genetic background of these electrical disorders and the current knowledge of genotype-phenotype interactions.
Boussy
Tim
T
Heart Rhythm Management Institute, University Hospital Brussels, Belgium, Laarbeeklaan 101 - 1090 Brussels, Belgium. tboussy@yahoo.com
Paparella
Gaetano
G
de Asmundis
Carlo
C
Sarkozy
Andrea
A
Chierchia
Gian Battista
GB
Brugada
Josep
J
Brugada
Ramon
R
Brugada
Pedro
P
D001145:Arrhythmias, Cardiac / Q000235:genetics*; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000235:genetics; D053840:Brugada Syndrome / Q000235:genetics; D002311:Cardiomyopathy, Dilated / Q000235:genetics; D016757:Death, Sudden, Cardiac; D006801:Humans; D040582:Inheritance Patterns; D008133:Long QT Syndrome / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015221:Potassium Channels / Q000235:genetics; D015222:Sodium Channels / Q000235:genetics
D015221:Potassium Channels; D015222:Sodium Channels