[Effects of Tangweian granule on 5-HT(2A)R in rat model with diabetic gastroparesis].
OBJECTIVE
To observe the effects of Tangweian granule on 5-HT(2A)R in rat model with diabetic gastroparesis (DGP).


METHODS
The rats with diabetic gastroparesis induced by injecting alloxan and giving 200% Radix Rehmanniae preparata were divided into four groups randomly: Tangweian high dosage group, Tangweian low dosage group, motilium control group and the model control group, 10 rats each group. Each group was irrigated with drugs during establishing the model. Additionally, we chose 10 rats by way of normal control group. Further more, Tangweian high dosage group were irrigated stomach with gliclazide 20 mg x kg(-1) and Tangweian granule 31.75 g x kg(-1); Tangweian low dosage group were irrigated stomach with gliclazide 20 mg x kg(-1) and Tangweian granule 15.88 g x kg(-1); motilium control group were irrigated stomach with gliclazide 20 mg x kg(-1) and motilium 3.75 mg x kg(-1) and the model control group were irrigated stomach with distilled water. Then the effects of Tangweian granule on 5-HT(2A)R were observed.


RESULTS
The curative group had better effects than the control group in lowering the blood sugar and the level of 5-HT(2A)R content (P < 0.01). And there was significant difference between the curative group and control group (P < 0.05).


CONCLUSIONS
It is verified that Tangweian granule has obvious effects on lowering the blood sugar and improving the level of 5-HT(2A)R.
Qingdao University, Qingdao 266071, China. qianqiuhai@126.com
Qiu-Hai
QH
Qian
Zhi-Cheng
ZC
Wang
Yi
Y
Zhao
Da-Wen
DW
Liu
Wei-Bin
WB
Qian
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000378:metabolism*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D018589:Gastroparesis / Q000188:drug therapy* / Q000378:metabolism; D005907:Gliclazide / Q000494:pharmacology; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D044402:Receptor, Serotonin, 5-HT2A; D005907:Gliclazide