Alpha-glucosidase inhibitors ellagic acid derivatives with immunoinhibitory properties from Terminalia superba.
Fractionation of stem barks of Terminalia superba yielded two new ellagic acid derivatives, 3,4'-di-O-methylellagic acid 3'-O-beta-D-xylopyranoside (1) and 4'-O-galloy-3,3'-di-O-methylellagic acid 4-O-beta-D-xylopyranoside (2) together with known 3,3'-di-O-methylellagic acid, ellagic acid and 3,3'-di-O-methylellagic acid 4'-O-beta-D-xylopyranoside. Compounds (1) and (2) showed significant alpha-glucosidase inhibition activity and possessed significant immunoinhibitory activities with no cytotoxic effects.
Tabopda
Turibio Kuiate
TK
Département de Chimie Organique, Université de Yaoundé I, Yaoundé, Cameroon. ttabopda@yahoo.fr
Ngoupayo
Joseph
J
Liu
Jiawei
J
Ali
Muhammad Shaiq
MS
Khan
Shamsun Nahar
SN
Ngadjui
Bonaventure Tchaleu
BT
Luu
Bang
B
D049109:Cell Proliferation / Q000187:drug effects; D004610:Ellagic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D006868:Hydrolysis; D007166:Immunosuppressive Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D049449:Luminescence; D009682:Magnetic Resonance Spectroscopy; D010586:Phagocytes / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts; D016897:Respiratory Burst / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013601:T-Lymphocytes / Q000187:drug effects; D029766:Terminalia / Q000737:chemistry*
D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007166:Immunosuppressive Agents; D010835:Phytohemagglutinins; D010936:Plant Extracts; D004610:Ellagic Acid