Synthesis of 7a-substituted Hajos-Wiechert ketone analogues.
A general and efficient route to 2-substituted 1,3-cyclopentadiones 3 has been developed. This operationally simple, two-step procedure is amenable to multigram scale preparations of these useful synthetic intermediates. These compounds are then transformed to previously unknown, higher analogues of the Hajos-Parrish-Eder-Sauer-Wiechert ketone (enone 1, R = Me) following an enantioselective Robinson annulation.
Medicinal Chemistry, Bayer Schering Pharma AG, 13342 Berlin, Germany.
Jason W J
JW
Kennedy
Sophia
S
Vietrich
Hilmar
H
Weinmann
Dominic E A
DE
Brittain