Induction therapy for elderly patients with acute myeloid leukemia.
Acute myeloid leukemia (AML) is a disease of older adults. Efforts to intensify therapy along traditional avenues have failed to yield improved results. There remains significant clinical equipoise as to how to "induce" patients and whether or not 7+3-style regimens improve outcomes over low-dose cytarabine. What is certain is that even in those not receiving active therapy, AML is an exceptionally morbid disease. Diverse interventions are being explored in the management of older patients with AML and the currently available data will be reviewed.
Martin
Mike G
MG
Section of Bone Marrow Transplantation and Leukemia, Division of Medical Oncology, Siteman Cancer Center, Washington University in Saint Louis, MO 63110, United States. mmartin@im.wustl.edu
Abboud
Camille N
CN
D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D003561:Cytarabine / Q000627:therapeutic use*; D005260:Female; D006299:Health Services for the Aged; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male
D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine