National French observatory of the quality of blood components for transfusion.
OBJECTIVE
Since 1998, prestorage leucoreduction of cellular blood components (BC) is mandatory in France. The French Blood Service needs to follow the data on the quality of the BC prepared by blood centers. This article gives an overview of the quality control (QC) data from 2001 to 2006.


METHODS
QC data are submitted to a central data bank by each centre. The data are stratified according to preparation process for analysis of key performance criteria - residual leukocytes and haemoglobin or platelet content. BC preparation processes, methods for measuring haemoglobin and platelet content, and for counting residual leukocytes are those routinely employed by centers.


RESULTS
The preparation process of red cell concentrates (RCC) influences the haemoglobin content: 57.6+/-6.8 g per unit versus 50.9+/-5.4 g per unit for whole blood or RCC filtration, respectively. Apheresis RCC exhibits a reduced variability (51.2+/-3.4 g per unit). For apheresis platelet concentrates, the median residual leukocyte count remains low for all separators (0.019-0.044 x 10(6)leukocytes per unit, in 2006). However, the percentage of units exceeding 1 x 10(6)leukocytes per unit is significantly higher with one separator (1.8% versus 0.8%, in 2006). For pooled buffy-coat derived platelets, we observed a significant increase in platelet recovery throughout the years (0.66-0.77 x 10(11)platelets per buffy-coat in 2001 and 2006, respectively).


CONCLUSIONS
Our QC data show an overall compliance with the requirements for cellular BC. Our data bank is useful to inform on the performance of leucoreduced BC preparation processes carried out with market available devices.
Etablissement français du sang, 20, avenue du Stade-de-France, 93218 La-Plaine-Saint-Denis cedex, France. anne.chabanel@efs.sante.fr
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D001771:Blood Banks / Q000458:organization & administration / Q000592:standards*; D016913:Blood Component Transfusion / Q000592:standards*; D001793:Blood Preservation / Q000379:methods; D016208:Databases, Factual; D017707:Erythrocyte Transfusion / Q000592:standards; D005602:France; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D047589:Leukocyte Reduction Procedures / Q000592:standards*; D017713:Platelet Transfusion / Q000592:standards; D011785:Quality Assurance, Health Care; D012996:Solutions
D006454:Hemoglobins; D012996:Solutions