Formulation design of microemulsion for dermal delivery of penciclovir.
The purpose of the present study was to evaluate the potential application of microemulsions as a dermal drug delivery loading penciclovir. The pseudo-ternary phase diagrams were developed for various microemulsion formulations composed of oleic acid (oil phase), Cremorphor EL (surfactant) and ethanol (cosurfactant). Composition of microemulsion systems was optimized using simplex lattice mixture design including the concentrations of surfactant, cosurfactant and water (independent variables) and the solubility and the cumulative amount of penciclovir permeated through excised mouse skins per unit area (response variables). The physicochemical properties of the optimized microemulsion and the permeating ability of penciclovir from microemulsions were also investigated. The results showed that the optimized microemusion formulation was composed of oleic acid (5%, w/w), Cremorphor EL (20%, w/w), ethanol (30%, w/w) and water (45%, w/w). The mean particle diameter was 36.5nm and solubility of penciclovir in the emulsion was 7.41 mg g(-1). The cumulative amount of penciclovir permeated through excised mouse skins from microemulsion was about 3.5 times that of the commercial cream. The conclusion was that the permeating ability of penciclovir was significantly increased from the microemulsion formulation compared with commercial cream.
Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China.
Weiwei
W
Zhu
Aihua
A
Yu
Weihong
W
Wang
Ruiqian
R
Dong
Jun
J
Wu
Guangxi
G
Zhai
D000212:Acyclovir / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D000465:Algorithms; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D015194:Diffusion Chambers, Culture; D015195:Drug Design; D004655:Emulsions; D000431:Ethanol / Q000737:chemistry; D005990:Glycerol / Q000031:analogs & derivatives; D006147:Guanine; D008297:Male; D051379:Mice; D009821:Oils / Q000737:chemistry; D012869:Skin Absorption; D013501:Surface-Active Agents / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000998:Antiviral Agents; D004655:Emulsions; D009821:Oils; D013501:Surface-Active Agents; D014867:Water; C053539:penciclovir; D000431:Ethanol; D006147:Guanine; C000515:cremophor EL; D005990:Glycerol; D000212:Acyclovir