Bioactivities of gossypol, 6-methoxygossypol, and 6,6'-dimethoxygossypol.
6-Methoxygossypol and 6,6'-dimethoxygossypol were recently isolated from the root tissue of cotton plants. Together with gossypol, these natural products were investigated for a wide range of bioactivities. Antioxidant effects, the potential to prevent DNA damage, anticancer activity, and antitrypanosomal effects were studied. The 6-methoxygossypol generally exhibited equal bioactivities to the 6,6'-dimethoxygossypol, but gossypol showed greater activities than both methylated derivatives in scavenging free radicals, reducing ferric ions, and preventing UV-induced DNA damage. All three compounds inhibited the growth of cervical (SiHa), breast (MCF-7), and colon (Caco-2) cancer cells. At >/=5 ppm of test concentrations, 6,6'-dimethoxygossypol showed a stronger ability than gossypol to inhibit the growth of Trypanosoma brucei cells.
Wang
Xi
X
Department of Genetic and Biochemistry, Department of Food Science and Human Nutrition, and Institute for Nutraceutical Research, Clemson University, Clemson, South Carolina 29634, USA. xiw@clemson.edu
Beckham
Thomas H
TH
Morris
James C
JC
Chen
Feng
F
Gangemi
J David
JD
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D004249:DNA Damage / Q000187:drug effects; D003368:Gossypium / Q000737:chemistry; D006072:Gossypol / Q000494:pharmacology*; D009281:Naphthalenes / Q000494:pharmacology*; D010636:Phenols / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D014346:Trypanosoma brucei brucei / Q000187:drug effects
C511022:6-methoxy gossypol; D000970:Antineoplastic Agents; D000975:Antioxidants; D009281:Naphthalenes; D010636:Phenols; D006072:Gossypol