Kinesin-8 molecular motors: putting the brakes on chromosome oscillations.
Recent studies suggest that the human Kinesin-8 molecular motor Kif18A has a role in chromosome congression. Specifically, these studies find that Kif18A promotes chromosome congression by attenuating chromosome oscillation magnitudes. Together with recent modeling work, in vitro studies, and the analysis of in vivo yeast data, these reports reveal how Kinesin-8 molecular motors might control chromosome oscillation amplitudes by spatially regulating the dynamic instability of microtubule plus-ends within the mitotic spindle.
Gardner
Melissa K
MK
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Odde
David J
DJ
Bloom
Kerry
K
D000818:Animals; D002875:Chromosomes / Q000648:ultrastructure*; D005786:Gene Expression Regulation; D006367:HeLa Cells; D006801:Humans; D016547:Kinesins / Q000737:chemistry* / Q000502:physiology*; D018386:Kinetochores / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000737:chemistry; D008870:Microtubules / Q000378:metabolism / Q000648:ultrastructure*; D008938:Mitosis; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism*; D009991:Oscillometry; D008941:Spindle Apparatus
D008869:Microtubule-Associated Proteins; D020409:Molecular Motor Proteins; C502735:KIF18A protein, human; D016547:Kinesins