Cytotoxicity of prenylated xanthones and other constituents from the wood of Garcinia merguensis.
One new prenylated xanthone 5-farnesyltoxyloxanthone B ( 4), three known xanthones alpha-mangostin ( 1), rubraxanthone ( 2) and isocowanol ( 3) as well as (2 E,6 E,10 E)-4beta-hydroxy-3-methyl-5beta-(3,7,11,15-tetramethylhexadeca-2,6,10-tetraenyl)-cyclohex-2-en-1-one ( 5) and 3,3',4- O-trimethylellagic acid were isolated from the wood of GARCINIA MERGUENSIS Wight. The cytotoxic activities of compounds 1 - 5 were evaluated against the MCF-7, MDA-MB-231, NCI-H-460 and SF-268 cell lines with rubraxanthone 2 and 5 exhibiting the highest activity at 9.0 and 12.1 microM, respectively, against MCF-7 cells.
Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto, Portugal.
Anake
A
Kijjoa
Maria Jose
MJ
Gonzalez
Madalena M
MM
Pinto
Maria São
MS
Nascimento
Nair
N
Campos
Ing-On
IO
Mondranondra
Artur M S
AM
Silva
Graham
G
Eaton
Werner
W
Herz
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D014934:Wood / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones; C472155:rubraxanthone