[Phospholipase A2, group IIa, as an earlier unknown immunohistological marker of cardiac myxoma].
Phospholipase A2, group IIA, gene expression has been analyzed in primary heart tumors. High expression has been demonstrated through several ways: reverse-transcriptase chain polymerase chain, Northern blotting hybridization at the RNA level and immunoblotting, immunohistochemical assay at the protein level. Human cardiac myxoma exhibits highly positive phospholipase A2, group IIA, immunophenotype (100% positive cases). The immunophenotype is unique among human primary cardiac tumors. Phospholipase A2, group IIA, can be proposed as a tissue marker for pathological examination after heart tumor resection.
Khaspekov
G L
GL
Sheremet'eva
G F
GF
Skamrov
A V
AV
Nechaenko
M A
MA
Vinnitskiĭ
L I
LI
Vlasik
T N
TN
Goriunova
L E
LE
Rutkevich
N M
NM
Peklo
M M
MM
Bibilashvili
R Sh
RSh
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000276:immunology / Q000378:metabolism*; D002648:Child; D005260:Female; D054501:Group II Phospholipases A2 / Q000276:immunology / Q000378:metabolism*; D006338:Heart Neoplasms / Q000201:enzymology* / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000201:enzymology* / Q000276:immunology / Q000473:pathology*
D014408:Biomarkers, Tumor; D054501:Group II Phospholipases A2; C516287:PLA2G2A protein, human