TGF-beta signaling in neuronal stem cells.
Transforming growth factor beta (TGF-beta) signaling has diverse and complex roles in various biological phenomena such as cell growth, differentiation, embryogenesis and morphogenesis. ES cells provide an essential model for understanding the role of TGF-beta signaling in lineage specification and differentiation. Recent studies have suggested significant role of TGF-beta in stem/progenitor cell biology. Here in this review, we focus on the role of the TGF-beta superfamily in neuronal development.
Laboratory of Developmental Neurobiology, Department of Surgery, Medicine & Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA.
Chohee
C
Yun
Jonathan
J
Mendelson
Tiffany
T
Blake
Lopa
L
Mishra
Bibhuti
B
Mishra
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D047108:Embryonic Development; D006801:Humans; D009024:Morphogenesis; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D051880:Receptors, Notch; D016212:Transforming Growth Factor beta