Rational design of cationic cyclooligosaccharides as efficient gene delivery systems.
Self-assembled cyclodextrin (CD)-DNA nanoparticles (CDplexes) exhibiting transfection efficiencies significantly higher than PEI-based polyplexes have been prepared from homogeneous seven-fold symmetric polyaminothiourea amphiphiles constructed on a beta-cyclodextrin scaffold.
Díaz-Moscoso
Alejandro
A
Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, Isla de la Cartuja, E-41092, Sevilla, Spain.
Balbuena
Patricia
P
Gómez-García
Marta
M
Ortiz Mellet
Carmen
C
Benito
Juan M
JM
Le Gourriérec
Loïc
L
Di Giorgio
Christophe
C
Vierling
Pierre
P
Mazzaglia
Antonino
A
Micali
Norberto
N
Defaye
Jacques
J
García Fernández
José M
JM
D002412:Cations / Q000737:chemistry; D018014:Gene Transfer Techniques; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature; D019076:Transgenes / Q000235:genetics*
D002412:Cations; D047028:Macrocyclic Compounds; D009844:Oligosaccharides