Sucutiniranes A and B, new cassane-type diterpenes from Bowdichia nitida.
Two new cassane-type diterpenes, sucutiniranes A (1) and B (2), have been isolated from the seeds of Bowdichia nitida together with 6alpha-acetoxyvouacapane (3) and 6alpha,7beta-diacetoxyvouacapane (4), and the structures of 1 and 2 were elucidated by using 2D NMR data and chemical correlations. Sucutinirane A (1) and 3 showed a moderate cytotoxicity against human colon carcinoma COLO201 cells, and 6alpha,7beta-diacetoxyvouacapane (4) showed in vitro antiplasmodial activity against parasite Plasmodium falciparum 3D7.
Matsuno
Yosuke
Y
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
Deguchi
Jun
J
Hirasawa
Yusuke
Y
Ohyama
Kunio
K
Toyoda
Hiroo
H
Hirobe
Chieko
C
Ekasari
Wiwied
W
Widyawaruyanti
Aty
A
Zaini
Noor Cholies
NC
Morita
Hiroshi
H
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D002277:Carcinoma / Q000188:drug therapy*; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010936:Plant Extracts / Q000494:pharmacology; D010944:Plants / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000378:metabolism; D012639:Seeds / Q000378:metabolism
D000962:Antimalarials; D004224:Diterpenes; D010936:Plant Extracts; C531398:sucutinirane A; C531399:sucutinirane B