DNA microarrays in the clinic: infectious diseases.
We argue that the most-promising area of clinical application of microarrays in the foreseeable future is the diagnostics and monitoring of infectious diseases. Microarrays for the detection and characterization of human pathogens have already found their way into clinical practice in some countries. After discussing the persistent, yet often underestimated, importance of infectious diseases for public health, we consider the technologies that are best suited for the detection and clinical investigation of pathogens. Clinical application of microarray technologies for the detection of mycobacteria, Bacillus anthracis, HIV, hepatitis and influenza viruses, and other major pathogens, as well as the analysis of their drug-resistance patterns, illustrate our main thesis.
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Vladimir
V
Mikhailovich
Dmitry
D
Gryadunov
Alexander
A
Kolchinsky
Alexander A
AA
Makarov
Alexander
A
Zasedatelev
D000818:Animals; D003141:Communicable Diseases / Q000175:diagnosis* / Q000191:economics / Q000235:genetics* / Q000401:mortality; D004352:Drug Resistance, Microbial; D005814:Genes, Viral; D006801:Humans; D008288:Malaria / Q000175:diagnosis / Q000382:microbiology; D025202:Molecular Diagnostic Techniques; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data*; D011634:Public Health / Q000379:methods; D013211:Staphylococcus aureus / Q000235:genetics / Q000378:metabolism