Novel open-chain cytochalsins from the marine-derived fungus Spicaria elegans.
Six novel open-chain cytochalasins (1-6) and one known [12]-cytochalasin (7) have been isolated from the fermentation broth of a marine-derived fungus, Spicaria elegans. Cytochalasins Z10-Z15 (1-6) are the first reported cytochalasins that contain an open chain to date. The structures of these new compounds were elucidated by spectroscopic methods. The cytotoxic effects on P388, A-549, HL-60, and BEL-7402 cell lines of all compounds were evaluated by the MTT method.
Liu
Rui
R
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, People's Republic of China.
Lin
Zhenjian
Z
Zhu
Tianjiao
T
Fang
Yuchun
Y
Gu
Qianqun
Q
Zhu
Weiming
W
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D003572:Cytochalasins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000737:chemistry*; D006801:Humans; D007941:Leukemia P388; D008386:Marine Biology; D051379:Mice; D015394:Molecular Structure
D000970:Antineoplastic Agents; D003572:Cytochalasins