Heart-brain interactions in cardiac arrhythmias: role of the autonomic nervous system.
The autonomic nervous system plays an important role in the genesis of ventricular arrhythmias and sudden cardiac death. Evidence is substantial for a neural component in sudden cardiac death. Sympathetic nerve sprouting and regional myocardial hyperinnervation following myocardial injury promote cardiac arrhythmia and sudden cardiac death through several potential mechanisms. Modulating autonomic tone is a potential method to reduce the risk of ventricular arrhythmias. Thoracic spinal cord stimulation is showing promise as a treatment for refractory angina. In addition, spinal cord stimulation has protected against ventricular tachycardia/ventricular fibrillation in animal models of postinfarction heart failure.
Division of Cardiology, Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. dzipes@iupui.edu
Douglas P
DP
Zipes
D001341:Autonomic Nervous System / Q000503:physiopathology*; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004558:Electric Stimulation / Q000379:methods; D006321:Heart / Q000294:innervation*; D006801:Humans; D010275:Parasympathetic Nervous System / Q000503:physiopathology; D011603:Psychophysiology; D012307:Risk Factors; D013564:Sympathetic Nervous System / Q000503:physiopathology; D017180:Tachycardia, Ventricular / Q000209:etiology* / Q000503:physiopathology; D014693:Ventricular Fibrillation / Q000209:etiology* / Q000503:physiopathology