Effects of oral L-arginine supplementation on blood pressure and asymmetric dimethylarginine in stress-induced preeclamptic rats.
This study was carried out to elucidate the role of asymmetric dimethylarginine (ADMA) and nitric oxide (NO) in preeclampsia development, and to investigate the effect of L-arginine supplementation in rats. Preeclampsia was induced in pregnant rats using a stress model. L-arginine was administered orally and ADMA, urinary nitrate, and protein levels were measured on the 20th day of pregnancy. Compared with the group of rats that are normally pregnant, the levels of blood pressure (BP), protein excretion, and ADMA were significantly increased in preeclampsia which returned to normal levels following the supplementation of L-arginine. Both group of rats had similar urine nitrate levels. Arginine-ADMA-NO pathway is affected in preeclampsia. L-arginine supplementation decreased hypertension (HT), proteinuria, and ADMA levels indicating that taking L-arginine may be beneficial in preeclampsia treatment.
Altun
Zekiye Sultan
ZS
Oncology Institute, Dokuz Eylül University, Izmir, Turkey. zekiye.altun@deu.edu.tr
Uysal
Sezer
S
Guner
Gul
G
Yilmaz
Osman
O
Posaci
Cemal
C
D000284:Administration, Oral; D000818:Animals; D001120:Arginine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005260:Female; D006973:Hypertension / Q000178:diet therapy / Q000378:metabolism* / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D011225:Pre-Eclampsia / Q000178:diet therapy* / Q000378:metabolism* / Q000503:physiopathology; D011247:Pregnancy; D011507:Proteinuria / Q000178:diet therapy / Q000378:metabolism* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects
C018524:N,N-dimethylarginine; D001120:Arginine