A randomised tandem colonoscopy trial of narrow band imaging versus white light examination to compare neoplasia miss rates.
OBJECTIVE
Colonoscopy, the "gold standard" screening test for colorectal cancer (CRC), has known diagnostic limitations. Advances in endoscope technology have focused on improving mucosal visualisation. In addition to increased angle of view and resolution features, recent colonoscopes have non-white-light optics, such as narrow band imaging (NBI), to enhance image contrast. We aimed to study the neoplasia diagnostic characteristics of NBI, by comparing the neoplasm miss rate when the colonoscopy was performed under NBI versus white light (WL).


METHODS
Randomised controlled trial.


METHODS
US Veterans hospital.


METHODS
Elective colonoscopy adults.


METHODS
We randomly assigned patients to undergo a colonoscopic examination using NBI or WL. All patients underwent a second examination using WL, as the reference standard.


METHODS
The primary end point was the difference in the neoplasm miss rate, and secondary outcome was the neoplasm detection rate.


RESULTS
In 276 tandem colonoscopy patients, there was no significant difference of miss or detection rates between NBI or WL colonoscopy techniques. Of the 135 patients in the NBI group, 17 patients (12.6%; 95% confidence interval (CI) 7.5 to 19.4%) had a missed neoplasm, as compared with 17 of the 141 patients (12.1%; 95% CI 7.2 to 18.6%) in the WL group, with a miss rate risk difference of 0.5% (95% CI -7.2 to 8.3). 130 patients (47%) had at least one neoplasm. Missed lesions with NBI showed similar characteristics to those missed with WL. All missed neoplasms were tubular adenomas, the majority (78%) was < or = 5 mm and none were larger than 1 cm (one-sided 95% CI up to 1%). Nonpolypoid lesions represented 35% (13/37) of missed neoplasms.


CONCLUSIONS
NBI did not improve the colorectal neoplasm miss rate compared to WL; the miss rate for advanced adenomas was less than 1% and for all adenomas was 12%. The neoplasm detection rates were similar high using NBI or WL; almost a half the study patients had at least one adenoma. Clinicaltrials.gov identifier: NCT00628147.
Kaltenbach
T
T
VA Palo Alto Health Care System, Stanford University School of Medicine, 3801 Miranda Ave, Palo Alto, CA 94304, USA.
Friedland
S
S
Soetikno
R
R
D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000517:prevention & control; D003111:Colonic Polyps / Q000175:diagnosis* / Q000517:prevention & control; D003113:Colonoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis*; D012680:Sensitivity and Specificity