[Effect of dinitrosyl iron complexes with thiol-containing ligands on the penile cavernosum bodies in rats].
A beneficial effect of dinitrosyl iron complexes (DNIC) with thiol-containing ligands on penile cavernus tissue was shown in rats subjected to penile denervation. Histological and histochemical investigations demonstrated that intracavernous injections of dinitrosyl iron complexes (2 times per one week during 6 months) blocked the reinforcement of endothelial cell proliferation in the tissue characteristic of the cavernous tissue when the penile nerve was removed. On the other hand, treatment with dinitrosyl iron complexes led to the preservation of mitotic activity of smooth myocytes and protected against the appearance in these cells of collagenase, an indicator of muscle transformation into fibrous tissue. It was shown that the process of fibrous transformation of myocytes correlates with a decrease in the mitotic activity of fibroblasts in the adventive part of cavernosa. The mitotic activity increased in cavernous tissue in the absence of dinitrosyl iron complexes. The efficiency of long-term action of dinitrosyl iron complexes on the erection in both intact animals and animals subjected to neuroectomy of cavernous tissue nerve was shown. The injection of low-molecular dinitrosyl iron complexes to the cavernous tissue resulted in the formation of protein-bound dinitrosyl iron complexes in the tissue, which were detected by the EPR technique. It is assumed that these dinitrosyl iron complexes function as a depot of nitric oxide, providing long-lasting penis erection.
E I
EI
Veliev
S V
SV
Kotov
V K
VK
Shishlo
V A
VA
Serezhenkov
V I
VI
Lozinskiĭ
A F
AF
Vanin
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003714:Denervation; D005296:Ferrous Compounds / Q000494:pharmacology*; D005355:Fibrosis; D005978:Glutathione / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D010410:Penile Erection / Q000187:drug effects*; D010413:Penis / Q000187:drug effects* / Q000294:innervation / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D005296:Ferrous Compounds; D020030:Nitric Oxide Donors; C072081:dinitrosyl-iron(II)-cysteine; C404202:dinitrosylbis(glutathione)iron(II); D005978:Glutathione; D003545:Cysteine