Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth.
Genetic studies in Drosophila have revealed that three tumor suppressors, Discs large (Dlg), Scribble (Scrib) and Lethal giant larvae (Lgl), which localize to the basolateral region of epithelial cells, cooperatively regulate cell polarity, junction formation and cell growth in epithelial cells. Subsequent studies in Drosophila, vertebrates and C. elegans have shown the evolutionary conservation of some of their functions in epithelial cells. Also, these studies revealed the importance of antagonistic interactions between these tumor suppressors and apical polarity regulators such as Crumbs and aPKC for the establishment of apical-basal polarity with organized cell-cell junctions and regulation of cell growth in epithelial cells.
Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako City, Saitama 351-0198, Japan.
Tomoyuki
T
Yamanaka
Shigeo
S
Ohno
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D002455:Cell Division / Q000502:physiology*; D000074288:Discs Large Homolog 1 Protein; D004330:Drosophila; D029721:Drosophila Proteins / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins; D008322:Mammals; D008565:Membrane Proteins / Q000502:physiology*; D011506:Proteins / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000378:metabolism / Q000502:physiology*; D014714:Vertebrates
D048868:Adaptor Proteins, Signal Transducing; D029742:Caenorhabditis elegans Proteins; C513314:DLG1 protein, human; D000074288:Discs Large Homolog 1 Protein; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; C116499:LGI1 protein, human; D008565:Membrane Proteins; D011506:Proteins; C480591:SCRIB protein, human; C404683:Scrib protein, Drosophila; D025521:Tumor Suppressor Proteins