Dermatologic immune restoration syndrome: report of five cases from a tertiary care center in north India.
BACKGROUND
Dermatologic conditions are often an early clue to human immunodeficiency virus (HIV) infection. As the disease progresses and the host immunity fails, patients may develop a number of skin conditions. At this point, they have a dominant T helper 2 immunologic response. After the initiation of antiretroviral therapy, the T helper 1 response is restored, and some skin problems, paradoxically, make their appearance then.


CONCLUSIONS
Herpes zoster, mucocutaneous herpes, eosinophilic folliculitis, and mycobacterial infections have been known to occur at this stage. This may be because immune restoration of a host's immunity causes recognition of silent or latent infection and results in development of the condition. We report five cases that were seen at our center during a 2-year period.
Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. handa_sanjeev@yahoo.com
Sanjeev
S
Handa
Tarun
T
Narang
Ajay
A
Wanchu
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D000328:Adult; D000818:Animals; D018791:CD4 Lymphocyte Count; D003937:Diagnosis, Differential; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006562:Herpes Zoster / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007194:India; D007918:Leprosy / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008924:Mite Infestations / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D011379:Prognosis; D012871:Skin Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D013577:Syndrome; D014382:Tuberculosis, Cutaneous / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D019562:Viral Load