Colloidal metallic gold is not bio-inert.
Metallic gold (Au degrees ) is a likely biotransformation product of monovalent gold, Au(I) whenever it is dissociated from in vivo ligands, Au degrees being formed either by bioreduction or by spontaneous dismutation (with co-production of trivalent gold). This review discusses the preparation and some biologically relevant properties of colloidal metallic gold (CMG) in its nano-particulate form. Tyndall's purple, a well characterised preparation of CMG, shows potent anti-arthritic activity in rats, approximately 10(3) times that of sodium aurothiomalate (Myocrysin). Even more remarkable is its broader spectrum of action in rats compared to this classic DMARD.
Brown
C L
CL
Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Science, Griffith University, Brisbane, Qld., 4111, Australia. c.l.brown@griffith.edu.au
Whitehouse
M W
MW
Tiekink
E R T
ER
Bushell
G R
GR
D000818:Animals; D001168:Arthritis / Q000188:drug therapy; D017979:Gold Colloid / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D006801:Humans; D053768:Metal Nanoparticles
D017979:Gold Colloid