First-trimester maternal serum PP13 in the risk assessment for preeclampsia.
OBJECTIVE
The objective of the study was to determine whether first-trimester maternal serum placental protein 13 (PP13) concentrations can be used in the risk assessment for preeclampsia.


METHODS
This case-control study included 50 patients with preeclampsia and 250 patients with normal pregnancies. Samples were collected between 8 and 13 weeks of gestation. Serum PP13 concentrations were measured by immunoassay and expressed as medians and multiples of the median (MoM) for gestational age. Sensitivity and specificity were derived from receiver-operating characteristic curve analysis.


RESULTS
(1) Serum PP13 concentration in the first trimester was significantly lower in patients who developed preterm and early-onset preeclampsia than in those with normal pregnancies; and (2) at 80% specificity, a cutoff of 0.39 MoM had a sensitivity of 100% for early-onset preeclampsia and 85% for preterm preeclampsia.


CONCLUSIONS
Maternal serum first-trimester PP13 appears to be a reasonable marker for risk assessment for preterm preeclampsia but a weak marker for severe preeclampsia at term, and ineffective for identifying mild preeclampsia at term.
Department of Health and Human Services, Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. prbchiefstaff@med.wayne.edu
Roberto
R
Romero
Juan Pedro
JP
Kusanovic
Nandor Gabor
NG
Than
Offer
O
Erez
Francesca
F
Gotsch
Jimmy
J
Espinoza
Samuel
S
Edwin
Ilana
I
Chefetz
Ricardo
R
Gomez
Jyh Kae
JK
Nien
Marei
M
Sammar
Beth
B
Pineles
Sonia S
SS
Hassan
Hamutal
H
Meiri
Yossi
Y
Tal
Ido
I
Kuhnreich
Zoltan
Z
Papp
Howard S
HS
Cuckle
D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D009842:Oligopeptides / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000453:epidemiology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First / Q000097:blood*; D018566:Pregnancy, High-Risk / Q000097:blood*; D012372:ROC Curve
D015415:Biomarkers; D009842:Oligopeptides; C116317:PPi3 penicillopepsin