Cytokine profile in collagen-induced arthritis: differences between syngeneic and allogeneic pregnancy.
OBJECTIVE
To identify the differences in cytokine profile between allogeneic and syngeneic pregnancy in mice with collagen-induced arthritis (CIA).


METHODS
Mice (strain B10.RIII) were injected with bovine collagen. Females were mated with males of the same strain (syngeneic pregnancy) or with males of strain B10. Q (allogeneic pregnancy). Concentrations of cytokines were measured during pregnancy and after delivery, and the onset and evolution of arthritis was followed in all female animals throughout the study period.


RESULTS
In female mice that developed CIA, cytokine concentrations were lower in allogeneic pregnancies than syngeneic pregnancies. When paired cytokine concentrations were compared in each animal during and after pregnancy, MCP-1 was lower during gestation than after delivery in both groups of pregnant mice, IL-6 was lower during gestation than after delivery only in allogeneic pregnancies, and IL-10 was lower during gestation than after delivery in allogeneic pregnancies, whereas in syngeneic pregnancies IL-10 was higher during gestation than after delivery.


CONCLUSIONS
Allogeneic pregnancy was associated with less arthritis because of lower concentrations of proinflammatory cytokines (IL-6 and others), not because of an increase in the concentration of antiinflammatory cytokines (IL-10).
González
D Almeida
DA
Research Unit, Hospital de La Candelaria, Santa Cruz de Tenerife, Canary Islands, Spain.
de León
A Cabrera
AC
Moncholi
C Vázquez
CV
Díaz
B Brito
BB
Pérez
M C Rodríguez
MC
Aguirre-Jaime
A
A
Coello
S Domínguez
SD
Hernández
A González
AG
D000818:Animals; D001169:Arthritis, Experimental / Q000097:blood / Q000276:immunology* / Q000473:pathology; D002417:Cattle; D016207:Cytokines / Q000097:blood / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000097:blood / Q000276:immunology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood / Q000276:immunology*
D016207:Cytokines