Short-term relative antibacterial effect of octenidine dihydrochloride on the oral microflora in orthodontically treated patients.
OBJECTIVE
To evaluate the efficacy of common antiseptic mouth rinses and octenidine dihydrochloride (OCT).


METHODS
The antibacterial activities of antiseptics against total and cariogenic bacteria (Streptococcus mutans and Lactobacillus species) in saliva were studied in vitro and in vivo. After unstimulated saliva was collected, one of the mouth rinse solutions was applied for 30seconds. Saliva samples were collected 15, 30, 60, and 120min later and evaluated for their bacterial count.


RESULTS
OCT had a significantly greater inhibitory effect on the studied bacteria than 0.2% chlorhexidine gluconate (CHX) and 7.5% polyvinylpyrrolidone-iodine complex (PVP-I) from 15min to 120min following the application (p<0.01). The antiseptic efficacy of 0.2% CHX on total bacteria and Lactobacillus species was very similar to the efficacy observed with 7.5% PVP-I mouth solution from 15min up to 120min. Streptococcus mutans was completely inhibited by 0.15mg/ml PVP-I, 0.5mg/ml CHX, and 0.1mg/ml OCT concentrations, while Streptococcus salivarius was inhibited by 0.15mg/ml PVP-I, 2mg/ml CHX, and 0.8mg/ml OCT concentrations. Lactococcus lactis subspecies lactis was inhibited with 0.00313mg/ml OCT, 30mg/ml PVP-I, and 0.0063mg/ml CHX concentrations.


CONCLUSIONS
OCT compared favorably with CHX and PVP-I in its antibacterial effects, both in vitro and in vivo (p<0.01).
Department of Orthodontics, Faculty of Dentistry, Suleyman Demirel University, Isparta, Turkey. alevak2000@yahoo.com
Alev Aksoy
AA
Dogan
Ali K
AK
Adiloglu
Suleyman
S
Onal
Emel Sesli
ES
Cetin
Esra
E
Polat
Ersin
E
Uskun
Fatih
F
Koksal
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000494:pharmacology; D015169:Colony Count, Microbial; D005260:Female; D006095:Gram-Positive Cocci / Q000187:drug effects*; D006801:Humans; D007097:Imines; D013294:Lactococcus lactis / Q000187:drug effects; D008297:Male; D008826:Microbial Sensitivity Tests; D009067:Mouthwashes / Q000494:pharmacology*; D009970:Orthodontics; D011206:Povidone-Iodine / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D012463:Saliva / Q000187:drug effects / Q000382:microbiology*; D013291:Streptococcus / Q000187:drug effects; D013295:Streptococcus mutans / Q000187:drug effects
D000900:Anti-Bacterial Agents; D007097:Imines; D009067:Mouthwashes; D011725:Pyridines; D011206:Povidone-Iodine; C010882:chlorhexidine gluconate; C034213:octenidine; D002710:Chlorhexidine