Multi-functional nanocarriers for targeted delivery of drugs and genes.
In this review article, we describe the different nano-platforms developed in our laboratory at Northeastern University in Boston, MA for the targeted delivery of drugs and genes. Special emphasis is placed on nano-platforms that offer opportunities for multi-functionalization to allow for targeted stimuli-responsive and/or simultaneous strategic delivery of multiple drugs, genes, as well as the combination of therapeutic systems with image contrast enhancers. Polymeric and lipid-based nanocarriers can provide versatile platforms for the delivery of multiple pharmacological agents, specifically to enhance therapeutic effect and overcome drug resistance in cancer. In addition, polymeric nanoparticles and nanoparticles-in-microsphere oral system (NiMOS) are useful for systemic and oral gene therapy, respectively.
Jabr-Milane
Lara
L
Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA.
van Vlerken
Lilian
L
Devalapally
Harikrishna
H
Shenoy
Dinesh
D
Komareddy
Sushma
S
Bhavsar
Mayank
M
Amiji
Mansoor
M
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D004247:DNA / Q000008:administration & dosage / Q000235:genetics; D004337:Drug Carriers / Q000737:chemistry*; D018014:Gene Transfer Techniques; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage
D003287:Contrast Media; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D004247:DNA