Recurrent relapses of depression in a patient established on sertraline after taking herbal medicinal mixtures--a herb-drug interaction?
We describe a patient with depression who was well controlled with sertraline monotherapy developing two relapses of depression in close temporal relationship with starting ayurvedic herbal mixtures. We discuss the possibility of a pharmacokinetic herb-drug interaction decreasing the therapeutic efficacy of sertraline leading to the relapses of depression. We speculate the herbal plant most likely to be responsible for this interaction is either Terminalia chebula or Commiphora wighteii.
Department of Pharmacology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka. ruwan@med.ruh.ac.lk
K P R C
KP
Prasad
P G D
PG
Tharangani
C N
CN
Samaranayake
D029744:Commiphora / Q000737:chemistry*; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D041743:Herb-Drug Interactions; D006801:Humans; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects; D012008:Recurrence; D017367:Selective Serotonin Reuptake Inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use; D020280:Sertraline / Q000493:pharmacokinetics* / Q000627:therapeutic use; D029766:Terminalia / Q000737:chemistry*
D010936:Plant Extracts; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline