Psychological stress induces hypoferremia through the IL-6-hepcidin axis in rats.
Anemia is a widespread public health problem. The psychological stress decreases serum iron level and inhibits erythropoiesis. However, the molecular mechanisms involved, leading to iron mal-regulation are not well known. We used a communication box paradigm to induce psychological stress and found that serum iron level decreased after 3d while liver iron storage increased after 7d. Moreover, psychological stress up-regulated expressions of interleukin-6 (IL-6) and hepcidin, while down-regulating ferroportin expression after 3d. These changes were blocked by the injection of IL-6 monoclonal antibody. In conclusion, the IL-6-hepcidin axis is up-regulated by psychological stress in rats, resulting in hypoferremia and increase of hepatic iron storage.
Zhao
Min
M
Department of Naval Medicine, Second Military Medical University, 800 Xiangxin Road, Shanghai 200433, PR China.
Chen
Jianbo
J
Wang
Wanyin
W
Wang
Lei
L
Ma
Long
L
Shen
Hui
H
Li
Min
M
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism*; D027682:Cation Transport Proteins / Q000378:metabolism; D015536:Down-Regulation; D064451:Hepcidins; D015850:Interleukin-6 / Q000378:metabolism*; D007501:Iron / Q000097:blood* / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological / Q000097:blood* / Q000378:metabolism*; D015854:Up-Regulation; D000098742:Ferroportin; D000093242:Interleukin-6 Inhibitors
D000911:Antibodies, Monoclonal; D023181:Antimicrobial Cationic Peptides; D027682:Cation Transport Proteins; D064451:Hepcidins; D015850:Interleukin-6; D007501:Iron; D000098742:Ferroportin; D000093242:Interleukin-6 Inhibitors; C578703:Hamp protein, rat