Synthesis and antimicrobial activities of some new triazolothiadiazoles bearing 4-methylthiobenzyl moiety.
A series of substituted triazolothiadiazoles have been synthesized by condensing 4-amino-3-[4-methylthiobenzyl]-4H-1,2,4-triazole-5-thiol (5) with substituted aryl furoic acids/aromatic acids in the presence of POCl3. The triazole (5) was obtained by the fusion of 4-methylthiophenyl acetic acid with thiocarbohydrazide. The structures of newly synthesized compounds are characterized by elemental analysis, IR, 1H NMR and mass spectroscopic studies and were screened for their antimicrobial activities. The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities.
Prasad
D Jagadeesh
DJ
Department of Chemistry, Mangalore University, Mangalagangothri 574199, Karnataka, India. jprasad_2003@yahoo.co.in
Ashok
Mithun
M
Karegoudar
Prakash
P
Poojary
Boja
B
Holla
B Shivarama
BS
Kumari
Nalilu Sucheta
NS
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles
D000890:Anti-Infective Agents; D013830:Thiadiazoles; D014230:Triazoles; C045575:1,2,4-triazole