The future of cancer vaccines for non-small-cell lung cancer: ongoing trials.
Lung cancer represents one of the malignancies in which the 3 elements of conventional therapy (ie, surgery, radiotherapy, and chemotherapy) have limited effectiveness in curbing progressive disease. In this context, there is burgeoning interest in the use of vaccine therapy as a nontoxic adjunct to increase the treatment success rates over those obtained with traditional regimens alone. Several clinical trials using a variety of vaccination strategies have been reported or are ongoing. In this review, we have provided an overview of these trials, with a special focus on the clinical efficacy of the vaccines. The future prospects and challenges of vaccine therapy in lung cancer have also been discussed.
Karolinska Institutet, Department of Oncology-Pathology, Cancer Centrum Karolinska, Stockholm, Sweden.
Aniruddha
A
Choudhury
Marzia
M
Palma
Håkan
H
Mellstedt
D019496:Cancer Vaccines / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000628:therapy*; D002986:Clinical Trials as Topic; D006801:Humans; D016233:Immunotherapy, Active / Q000639:trends*; D008175:Lung Neoplasms / Q000628:therapy*
D019496:Cancer Vaccines