Catalytic Michael reactions of ketoesters with a camphor-derived acrylate equivalent: stereoselective access to all-carbon quaternary centers.
A camphor-based alpha'-hydroxy enone reagent acts as a chiral acrylate equivalent in copper-catalyzed Michael reactions of beta-keto esters and affords products that possess all-carbon quaternary stereocenters of high enantiomeric purity.
Palomo
Claudio
C
Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián, Spain. claudio.palomo@ehu.es
Oiarbide
Mikel
M
García
Jesús M
JM
Bañuelos
Patricia
P
Odriozola
José M
JM
Razkin
Jesús
J
Linden
Anthony
A