[Effect of arecholine and atropine administration on the carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase activities in the rat nervous tissue].
The effect of a single dose administration of arecholine and atropine on the activities of carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase involved into the final stage of formation of biologically active neuropeptides from precursors has been studied. Changes in the enzyme activities were evident during at least 72 h after administration of these drugs. These results suggest that one of possible mechanisms of reduction of neuropeptide levels by arecholine and atropine consists in suppression of activity of enzymes taking part in there metabolism--carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase.
V B
VB
Solov'ev
M T
MT
Gengin
D000311:Adrenal Glands / Q000187:drug effects* / Q000201:enzymology; D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D043423:Carboxypeptidase H / Q000378:metabolism; D002268:Carboxypeptidases / Q000378:metabolism*; D018678:Cholinergic Agents / Q000494:pharmacology*; D018679:Cholinergic Agonists / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology; D008297:Male; D009928:Organ Specificity; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology*; D051381:Rats
D018678:Cholinergic Agents; D018679:Cholinergic Agonists; D018680:Cholinergic Antagonists; D001115:Arecoline; D010664:Phenylmethylsulfonyl Fluoride; D001285:Atropine; D002268:Carboxypeptidases; D043423:Carboxypeptidase H