O:8 serotype Yersinia enterocolitica strains in China.
Serotypes O:3, O:8 and O:9 Yersinia enterocolitica strains carrying virulence determinants are common pathogens causing human infections. In many years of surveillance in China for Y. enterocolitica, no pathogenic O:8 strains have been found where the isolated O:8 serotypes lacked the major virulence genes and in contrast to O:3 and O:9 strains, none of the O:8 isolates were from humans. These O:8 isolates lack ail, ystA, yadA and virF genes but possess the ystB gene and all belong to Biotype 1A. These O:8 strains did not kill mice and could protect immunized mice against challenge with a pathogenic O:8 strain. Compared to the Chinese pathogenic O:3 and O:9 strains which have similar pulsed-field gel electrophoresis patterns, the 39 Chinese O:8 animal and food isolates were different from the pathogenic O:8 reference strains. This suggests the O:8 strains lacking virulence determinants may not disseminate rapidly in humans and are maintained in animal reservoirs; and therefore exhibit higher variance and divergence from the virulent type.
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 102206, Beijing, China.
Xin
X
Wang
Haiyan
H
Qiu
Dong
D
Jin
Zhigang
Z
Cui
Biao
B
Kan
Yuchun
Y
Xiao
Yanmei
Y
Xu
Shengli
S
Xia
Hua
H
Wang
Jinchuan
J
Yang
Xianjun
X
Wang
Wanfu
W
Hu
Jianguo
J
Xu
Huaiqi
H
Jing
D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D002681:China; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D005516:Food Microbiology; D006801:Humans; D051379:Mice; D011897:Random Allocation; D012703:Serotyping; D014407:Tumor Cells, Cultured; D014774:Virulence; D037521:Virulence Factors / Q000737:chemistry / Q000235:genetics*; D015009:Yersinia Infections / Q000382:microbiology* / Q000517:prevention & control; D015008:Yersinia enterocolitica / Q000145:classification* / Q000235:genetics / Q000472:pathogenicity*
D001428:Bacterial Vaccines; D004269:DNA, Bacterial; D037521:Virulence Factors