[Serum concentration of selected adhesive molecules in early localised and late disseminated Lyme borreliosis].
Serum concentration of soluble form ICAM-1, PECAM-1, VAP-1, E-selectin, VCAM-1 in 20 patients with Erythema migrans and 20 patients with Lyme arthritis before and after 4-weeks antibiotic treatment were estimated. Comparing group consited 8 healthy volunteers. Concentrations of soluble molecules were performed with ELISA kits(Bender MedSystem, Austria). Results of the study indicate involvment of soluble form ICAM-1, PECAM-1, VAP-1, E-selectin and VCAM-1 in immunopathogenesis of Lyme borreliosis, and different engagement of molecules in depend on stage of disease. In early localized stage of disease, results suggest participation molecules engaged in all stages of "adhesion cascade" whilst in disseminated, late stage of Lyme borreliosis molecules of tight adhesion. The measurement of soluble form od aadhesion molecules can be useful of in differentiation of localized and disseminated late stages of Lyme borreliosis helpful in clinical diagnosis.
Klinika Chorób Zakaźnych i Neuroinfekcji Akademia Medyczna w Białymstoku. zajkowsk@neostrada.pl
Joanna
J
Zajkowska
Joanna
J
Stalewska
Maciej
M
Kondrusik
Justyna
J
Kuśmierczyk
Piotr
P
Czupryna
Sambor
S
Grygorczuk
Sławomir
S
Pancewicz
D000328:Adult; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008193:Lyme Disease / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000097:blood*; D011237:Predictive Value of Tests; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D015415:Biomarkers; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; C076668:AOC3 protein, human; D006631:Amine Oxidase (Copper-Containing)