A facile access to pyrroles from amino acids via an aza-Wacker cyclization.
A facile and efficient synthesis of pyrroles from readily available amino acids is described. The key step in the method is an aza-Wacker oxidative cyclization catalyzed by palladium(II)/Cu(OTf)2. A series of pyrroles were obtained by this method under mild conditions.
Joint Laboratory of Green Synthetic Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
Zuhui
Z
Zhang
Jintang
J
Zhang
Jiajing
J
Tan
Zhiyong
Z
Wang
D000596:Amino Acids / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis*
D000596:Amino Acids; D011758:Pyrroles