Ameliorating effect of balloon flower saponin on the ethanol-induced memory impairment in mice.
The ameliorating effect of the root extract of Platycodon grandiflorum (Campanulaceae) on ethanol-induced cognitive dysfunction in mice was investigated. The mice with repeated administration of the root extract of P. grandiflorum, crude saponin fraction and platycoside E, a main ingredient of crude saponin fraction, showed a markedly prolonged step-through latency period (STL) on the passive avoidance task performed after acute ethanol intoxication, respectively. The present results suggest that the memory enhancing effect of the extract was ascribed mainly to the saponin fraction and that saponin of P. grandiflorum, particularly platycoside E could exert a beneficial effect on memory impairment in mice.
Choi
Yeon Hee
YH
Korea Research Institute of Chemical Technology, Taejeon 305-606, Korea.
Kim
Young Sup
YS
Yeo
Su Jeong
SJ
Roh
Seong Hwan
SH
Jeong
Young Chul
YC
Kang
Jong Seong
JS
Ryu
Shi Yong
SY
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D029422:Campanulaceae / Q000737:chemistry*; D002492:Central Nervous System Depressants / Q000037:antagonists & inhibitors / Q000633:toxicity; D003071:Cognition / Q000187:drug effects / Q000502:physiology; D003072:Cognition Disorders / Q000139:chemically induced / Q000517:prevention & control / Q000523:psychology; D004195:Disease Models, Animal; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000633:toxicity; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control* / Q000523:psychology; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D012503:Saponins / Q000494:pharmacology*
D002492:Central Nervous System Depressants; D010936:Plant Extracts; D012503:Saponins; D000431:Ethanol