A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg(-1) day(-1)), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.
LifeGen Technologies, LLC, Madison, Wisconsin, United States of America.
Jamie L
JL
Barger
Tsuyoshi
T
Kayo
James M
JM
Vann
Edward B
EB
Arias
Jelai
J
Wang
Timothy A
TA
Hacker
Ying
Y
Wang
Daniel
D
Raederstorff
Jason D
JD
Morrow
Christiaan
C
Leeuwenburgh
David B
DB
Allison
Kurt W
KW
Saupe
Gregory D
GD
Cartee
Richard
R
Weindruch
Tomas A
TA
Prolla
D000375:Aging / Q000235:genetics; D000818:Animals; D031204:Caloric Restriction; D004702:Endocrine Glands / Q000378:metabolism; D020869:Gene Expression Profiling; D005947:Glucose / Q000378:metabolism; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000187:drug effects; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage* / Q000494:pharmacology
D013267:Stilbenes; D005947:Glucose; D000077185:Resveratrol