Preparation and characterization of modified hydroxyapatite particles by heparin.
Heparin-modified hydroxyapatite (HAP-HP) particles were prepared by an in situ coprecipitation method and were characterized by Fourier transform infrared spectrometry, x-ray diffraction and transmission electron microscopy. The heparin content in the particles was determined by a colorimetric assay and energy dispersive x-ray spectroscopy. Final results indicated that the crystallinity and crystal size decreased as both the Ca/P molar ratio and sulfur content increased by adding heparin. Blood compatibility of the HAP-HP particles was evaluated by activated partial thrombin time and prothrombin time. The clotting time of HAP-HP was prolonged remarkably compared with that of HAP. Above all, this novel HAP-HP material can be potentially applied as compatible blood materials for drug carriers of intravenous injection and artificial blood vessels.
The Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China.
D M
DM
Zhao
Y X
YX
Wang
Z Y
ZY
Chen
R W
RW
Xu
G
G
Wu
D S
DS
Yu
D000925:Anticoagulants / Q000008:administration & dosage / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D001777:Blood Coagulation / Q000187:drug effects*; D004343:Drug Implants / Q000008:administration & dosage* / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D006493:Heparin / Q000008:administration & dosage* / Q000737:chemistry*; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D014914:Whole Blood Coagulation Time
D000925:Anticoagulants; D001672:Biocompatible Materials; D004343:Drug Implants; D006493:Heparin; D017886:Durapatite