Isolation and biological activity of new norhirsutanes from Creolophus cirrhatus.
Five new norhirsutanes, named creolophins A-E, and complicatic acid were isolated from the culture broth of the rare tooth fungus Creolophus cirrhatus by solvent extraction, silica gel column chromatography and HPLC. In addition, neocreolophin, a complex dimerization product, was formed as an artefact during purification. The structures were elucidated by spectroscopic methods and are published in a separate paper. Two of the metabolites showed moderate antibacterial, antifungal and cytotoxic activities.
University of Kaiserslautern, Paul-Ehrlich-Str. 23, D-67663 Kaiserslautern, Germany.
Judith
J
Birnbacher
Anja
A
Schüffler
Friederike
F
Deininger
Till
T
Opatz
Timm
T
Anke
D000363:Agaricales / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001943:Breast Neoplasms; D002460:Cell Line; D045744:Cell Line, Tumor / Q000187:drug effects; D005260:Female; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D019169:Jurkat Cells; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000970:Antineoplastic Agents; D012717:Sesquiterpenes