Puma: mauling the intestinal crypt.
Cancer therapies utilizing chemotherapy or radiotherapy are constrained by risk of intestinal stem cell death. In this issue of Cell Stem Cell, Qiu et al. report that Puma deletion prevents intestinal degeneration following DNA damage, thus offering a target protein for the design of enhanced cancer treatments.
Clarke
Alan R
AR
School of Biosciences, Cardiff University, CF10 3US, UK. clarkear@cardiff.ac.uk
D053687:Adult Stem Cells / Q000166:cytology / Q000528:radiation effects*; D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000528:radiation effects; D051017:Apoptosis Regulatory Proteins / Q000235:genetics* / Q000528:radiation effects; D041981:Gastrointestinal Tract / Q000166:cytology / Q000528:radiation effects*; D005786:Gene Expression Regulation / Q000235:genetics / Q000528:radiation effects; D051379:Mice; D009369:Neoplasms / Q000532:radiotherapy; D011833:Radiation Injuries, Experimental / Q000235:genetics* / Q000473:pathology; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000528:radiation effects
D051017:Apoptosis Regulatory Proteins; C488588:PUMA protein, mouse; D025521:Tumor Suppressor Proteins