Hedgehog signalling in endocrine development and disease.
The hedgehog (Hh) pathway is an evolutionarily conserved signalling pathway that is required for many essential tissue and cellular properties such as patterning fields of cells or regulating cell differentiation and proliferation. Disruption of the pathway results in serious pathologies. In this review, we provide an update on recent findings in the field of vertebrate Hh signalling and also describe contributions of Hh signalling to the development, maintenance and pathology of endocrine tissues.
Barts and the London School of Medicine, Centre for Endocrinology, London EC1M 6BQ, UK. p.j.king@qmul.ac.uk
Peter J
PJ
King
Leonardo
L
Guasti
Ed
E
Laufer
D000818:Animals; D004703:Endocrine System / Q000254:growth & development / Q000378:metabolism* / Q000473:pathology*; D053823:Hedgehog Proteins / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*
D053823:Hedgehog Proteins