Synthesis and antimicrobial activities of some new triazolothiadiazoles bearing 4-methylthiobenzyl moiety.
A series of substituted triazolothiadiazoles have been synthesized by condensing 4-amino-3-[4-methylthiobenzyl]-4H-1,2,4-triazole-5-thiol (5) with substituted aryl furoic acids/aromatic acids in the presence of POCl3. The triazole (5) was obtained by the fusion of 4-methylthiophenyl acetic acid with thiocarbohydrazide. The structures of newly synthesized compounds are characterized by elemental analysis, IR, 1H NMR and mass spectroscopic studies and were screened for their antimicrobial activities. The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities.
Department of Chemistry, Mangalore University, Mangalagangothri 574199, Karnataka, India. jprasad_2003@yahoo.co.in
D Jagadeesh
DJ
Prasad
Mithun
M
Ashok
Prakash
P
Karegoudar
Boja
B
Poojary
B Shivarama
BS
Holla
Nalilu Sucheta
NS
Kumari
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles
D000890:Anti-Infective Agents; D013830:Thiadiazoles; D014230:Triazoles; C045575:1,2,4-triazole