[Micro RNA, C/D RNA and parental genoming imprinting.].
Experimental and computer-assisted approaches have led us to identify hundreds of small non-coding RNA (ncRNAs) whose genes - clustered at two chromosomal domains (the DLK1-GTl2 region/human 15q11q13 and the SNURF-SNRPN/human 14q32 loc) - are subjected to genomic imprinting. Here, we discuss their genomic organization, their expression pattern and their potential functions.
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Jérôme
J
Laboratoire de Biologie Moléculaire des Eucaryotes LBME - CNRS UMR 5099 - IFR 109, Université Paul Sabatier, 118, Route de Narbonne 31062 - Toulouse Cedex, France.
D000818:Animals; D002135:Calcium-Binding Proteins; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D018392:Genomic Imprinting / Q000235:genetics*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D008957:Models, Genetic; D009473:Neuronal Plasticity / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology; D059372:Nucleotide Motifs; D011218:Prader-Willi Syndrome / Q000235:genetics; D051560:Proto-Oncogene Proteins c-bcl-6; D017393:RNA Editing; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics; D062085:RNA, Long Noncoding; D058727:RNA, Small Untranslated
C084103:BCL6 protein, human; D002135:Calcium-Binding Proteins; C512941:DLK1 protein, human; D004268:DNA-Binding Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D035683:MicroRNAs; D009687:Nuclear Proteins; D051560:Proto-Oncogene Proteins c-bcl-6; D062085:RNA, Long Noncoding; D058727:RNA, Small Untranslated; C445239:SNURF protein, human