Synthesis of substituted benzofurans via microwave-enhanced catch and release strategy.
A microwave-enhanced procedure for the synthesis of substituted benzofurans starting from 2-(1-hydroxyalkyl)-phenols and using triphenylphosphine polystirene resin is reported. The benzofurans are isolated in good to high yields and purities by simple workup. The procedure can be applied to chiral alpha-alkyl-2-benzofuranmethanamines too.
Luca
Lidia De
LD
Dipartimento di Chimica, Università degli Studi di Sassari, via Vienna 2, I-07100, Italy.
Giacomelli
Giampaolo
G
Nieddu
Giammario
G
D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D017605:Bromine Compounds / Q000138:chemical synthesis / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure
D001572:Benzofurans; D017605:Bromine Compounds