Home is where the heart is: via the FROUNT.
In this issue of Cell Stem Cell, Belema-Bedada et al. (2008) describe a novel mechanism by which bone marrow-derived adult mesenchymal stem cells migrate to sites of damaged heart tissue. This process is dependent on the intracellular adaptor molecule FROUNT, which interacts with the chemokine receptor CCR2.
Zannettino
Andrew C W
AC
Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia.
Psaltis
Peter J
PJ
Gronthos
Stan
S
D053687:Adult Stem Cells / Q000166:cytology* / Q000378:metabolism*; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000378:metabolism; D054443:Cell Migration Assays; D002465:Cell Movement; D033922:Clathrin Heavy Chains / Q000235:genetics* / Q000378:metabolism*; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism*; D051379:Mice; D009206:Myocardium / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis; D009928:Organ Specificity; D054390:Receptors, CCR2 / Q000235:genetics / Q000378:metabolism*; D015427:Reperfusion Injury / Q000097:blood / Q000473:pathology; D019076:Transgenes / Q000235:genetics
C515335:Ccr2 protein, mouse; C503215:FROUNT protein, mouse; D054390:Receptors, CCR2; D033922:Clathrin Heavy Chains