Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice.
Plasmonic photothermal therapy (PPTT) is a minimally-invasive oncological treatment strategy in which photon energy is selectively administered and converted into heat sufficient to induce cellular hyperthermia. The present work demonstrates the feasibility of in vivo PPTT treatment of deep-tissue malignancies using easily-prepared plasmonic gold nanorods and a small, portable, inexpensive near-infrared (NIR) laser. Dramatic size decreases in squamous cell carcinoma xenografts were observed for direct (P<0.0001) and intravenous (P<0.0008) administration of pegylated gold nanorods in nu/nu mice. Inhibition of average tumor growth for both delivery methods was observed over a 13-day period, with resorption of >57% of the directly-injected tumors and 25% of the intravenously-treated tumors.
School of Biology, Ovarian Cancer Institute, Georgia Institute of Technology, Atlanta, GA 30332-0400, USA.
Erin B
EB
Dickerson
Erik C
EC
Dreaden
Xiaohua
X
Huang
Ivan H
IH
El-Sayed
Hunghao
H
Chu
Sujatha
S
Pushpanketh
John F
JF
McDonald
Mostafa A
MA
El-Sayed
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D005260:Female; D006046:Gold / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D051379:Mice; D043942:Nanotubes / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared; D020349:Surface Plasmon Resonance
D006046:Gold