Fat and beyond: the diverse biology of PPARgamma.
The nuclear receptor PPARgamma is a ligand-activated transcription factor that plays an important role in the control of gene expression linked to a variety of physiological processes. PPARgamma was initially characterized as the master regulator for the development of adipose cells. Ligands for PPARgamma include naturally occurring fatty acids and the thiazolidinedione (TZD) class of antidiabetic drugs. Activation of PPARgamma improves insulin sensitivity in rodents and humans through a combination of metabolic actions, including partitioning of lipid stores and the regulation of metabolic and inflammatory mediators termed adipokines. PPARgamma signaling has also been implicated in the control of cell proliferation, atherosclerosis, macrophage function, and immunity. Here, we review recent advances in our understanding of the diverse biological actions of PPARgamma with an eye toward the expanding therapeutic potential of PPARgamma agonist drugs.
Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, University of California-Los Angeles, CA 90095, USA. ptontonoz@mednet.ucla.edu
Peter
P
Tontonoz
Bruce M
BM
Spiegelman
D017667:Adipocytes / Q000166:cytology*; D050156:Adipogenesis; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D007333:Insulin Resistance; D008264:Macrophages / Q000166:cytology*; D008954:Models, Biological; D008958:Models, Molecular; D009369:Neoplasms / Q000378:metabolism; D047495:PPAR gamma / Q000819:agonists / Q000378:metabolism*; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D045162:Thiazolidinediones / Q000737:chemistry
D047495:PPAR gamma; D045162:Thiazolidinediones; C089946:2,4-thiazolidinedione