Physico/chemical characterization and in vivo evaluation of nanothickness bioceramic depositions on alumina-blasted/acid-etched Ti-6Al-4V implant surfaces.
The objective of this study was to physico/chemically characterize and evaluate the in vivo performance of two nanothickness ion beam assisted depositions (IBAD) of bioceramic coatings on implants in a beagle model. Alumina-blasted/acid-etched (AB/AE) Ti-6Al-4V implants were subjected to two different IBAD depositions (IBAD I and IBAD II), which were physico/chemically characterized by SEM, EDS, XPS, XPS + ion-beam milling (depth profiling), XRD, AFM, and ToF-SIMS. A beagle dog tibia model was utilized for histomorphometric and biomechanical (torque) comparison between AB/AE, IBAD I, IBAD II, and plasma-sprayed hydroxyapatite (PSHA) coated implants that remained in vivo for 3 and 5 weeks. The coatings were characterized as amorphous Ca-P with high Ca/P stoichiometries with thicknesses of an order of magnitude difference (IBAD I = 30-50 nm and IBAD II = 300-500 nm). The histomorphometric and biomechanical testing results showed that the 300-500 nm thickness deposition (IBAD II) and PSHA positively modulated bone healing at early implantation times.
Coelho
Paulo G
PG
Department of Biomaterials and Biomimetics, New York University, 345 24th Street, Room 804a, New York, New York 10010, USA. pgcoelho@nyu.edu
Lemons
Jack E
JE
D000143:Acids / Q000737:chemistry; D000497:Alloys; D000537:Aluminum Oxide / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001696:Biomechanical Phenomena; D018786:Bone Substitutes; D002516:Ceramics / Q000737:chemistry*; D004285:Dogs; D017886:Durapatite / Q000737:chemistry; D017102:Fracture Healing; D008297:Male; D013314:Stress, Mechanical; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D019415:Torque
D000143:Acids; D000497:Alloys; D001672:Biocompatible Materials; D018786:Bone Substitutes; C031462:titanium alloy (TiAl6V4); D017886:Durapatite; D014025:Titanium; D000537:Aluminum Oxide