Autofluorescence in adult-onset foveomacular vitelliform dystrophy.
OBJECTIVE
To describe fundus autofluorescence (FAF) characteristics of adult-onset foveomacular vitelliform dystrophy (AOFVD) and to perform a comparative evaluation of FAF patterns and functional response.


METHODS
Fifteen patients with AOFVD and 10 healthy volunteers underwent complete ophthalmic examination, including visual acuity determination (Early Treatment Diabetic Retinopathy Study charts), blue-light autofluorescence (BL-AF) analysis, near-infrared autofluorescence (NIR-AF) analysis, and microperimetry.


RESULTS
: Three different patterns of BL-AF (normal, focal, and patchy) and two of NIR-AF (focal and patchy) were identified in AOFVD. Abnormal BL-AF and NIR-AF patterns were detectable in 86% and 100% of cases, respectively. Patchy BL-AF and NIR-AF patterns are associated with the worst functional outcomes.


CONCLUSIONS
AOFVD can be associated with different FAF patterns. A functional correlate with visual acuity and retinal sensitivity, measured by means of microperimetry, can be found.
Parodi
Maurizio Battaglia
MB
Eye Clinic, Azienda Ospedaliero-Universitaria di Trieste, Trieste, Italy. maubp@yahoo.it
Iacono
Pierluigi
P
Pedio
Marcella
M
Pece
Alfredo
A
Isola
Vincenzo
V
Fachin
Alessandro
A
Pinto
Marinella
M
Ravalico
Giuseppe
G
D000368:Aged; D005260:Female; D005453:Fluorescence; D005584:Fovea Centralis / Q000378:metabolism / Q000473:pathology*; D005654:Fundus Oculi; D006801:Humans; D008062:Lipofuscin / Q000378:metabolism; D008297:Male; D010857:Pigment Epithelium of Eye / Q000378:metabolism / Q000473:pathology; D011726:Pyridinium Compounds / Q000378:metabolism; D012162:Retinal Degeneration / Q000378:metabolism / Q000473:pathology*; D012176:Retinoids / Q000378:metabolism; D014792:Visual Acuity; D058609:Visual Field Tests
C112040:A2-E (N-retinylidene-N-retinylethanolamine); D008062:Lipofuscin; D011726:Pyridinium Compounds; D012176:Retinoids