The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts.
Pratt
William B
WB
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Morishima
Yoshihiro
Y
Osawa
Yoichi
Y
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002468:Cell Physiological Phenomena; D005786:Gene Expression Regulation; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism; D008969:Molecular Sequence Data; D011485:Protein Binding; D011489:Protein Denaturation; D017510:Protein Folding
D018841:HSP90 Heat-Shock Proteins; D008024:Ligands; D018832:Molecular Chaperones