Myocardial involvement during the early course of type 2 diabetes mellitus: usefulness of myocardial performance index.
To evaluate whether myocardial performance index detects a subclinical impairment of left ventricular systolic and diastolic function in patients with early stage of type 2 diabetes, without coronary artery disease, with or without hypertension. Furthermore, to evaluate whether some echocardiographic parameters relate to the metabolic control. Fourty-five consecutive male patients (mean age 52.5 years) with type 2 diabetes mellitus of recent onset (23 hypertensives and 22 normotensives) and 22 age matched healthy controls males were analysed. All participants had normal exercise ECG. All subjects underwent standard and Doppler echocardiography for the assessment of the isovolumic Doppler time interval and Doppler-derived myocardial performance index. In all diabetic patients a glycated haemoglobin test was also performed. No differences were observed in blood pressure, heart rate, and conventional echocardiographic parameters comparing the 2 subgroups of diabetic patients and the controls. Myocardial performance index was significantly higher in diabetic patients independently of the hypertension occurrence, compared to the controls (0.49 and 0.49 diabetic normotensives and hypertensives respectively vs. 0.39, p < 0.01). Myocardial performance index correlated to glycated haemoglobin significantly (r = 0.37, p < 0.01) in both diabetic subgroups. Thus, an early involvement of left ventricular performance was shown by myocardial performance index in patients with type 2 diabetes of recent onset without coronary artery disease, independently of the hypertension presence. These abnormalities can provide a feasible approach to detect a pre-clinical diabetic cardiomyopathy and could be useful for an indirect assessment of the metabolic control.
Pattoneri
Paolo
P
Department of Internal Medicine, Nephrology and Health Sciences, University of Parma, Italy. pattopaolo@libero.it
Sozzi
Fabiola B
FB
Catellani
Elisabetta
E
Piazza
Antonella
A
Iotti
Roberto
R
Michelini
Massimo
M
Goldoni
Matteo
M
Borghetti
Alberico
A
Cappellini
Maria Domenica
MD
Manicardi
Valeria
V
D000704:Analysis of Variance; D001795:Blood Pressure Determination; D016022:Case-Control Studies; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000453:epidemiology*; D018619:Echocardiography, Doppler, Pulsed / Q000379:methods; D005080:Exercise Test; D006442:Glycated Hemoglobin / Q000032:analysis*; D006334:Heart Function Tests; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D012720:Severity of Illness Index; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000453:epidemiology*
D006442:Glycated Hemoglobin