Recombinant human interleukin-2 inhalation powders: preparation and distribution in the alveolus.
The aim of this work was to prepare recombinant human interleukin-2 (rhIL-2) inhalation powders, and the important parameters such as particle size, the remaining ratio of rhIL-2 were also studied. To elucidate the target effect of rhIL-2 inhalation powders, an in situ pharmacokinetic two-compartment model was used to explain their distribution characteristics in lung epithelial lining fluid and alveolar macrophage in the alveolus after the administration of the rhIL-2 inhalation powders in rats.
Yue
Tang
T
School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China. tangyuetian@sina.com
Jia-bi
Zhu
Z
D000280:Administration, Inhalation; D000465:Algorithms; D000818:Animals; D002626:Chemistry, Pharmaceutical; D003890:Desiccation; D004339:Drug Compounding; D005260:Female; D007376:Interleukin-2 / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000378:metabolism; D010316:Particle Size; D011208:Powders; D011650:Pulmonary Alveoli / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000493:pharmacokinetics; D020545:Respiratory Mucosa / Q000378:metabolism
D007376:Interleukin-2; D011208:Powders; D011994:Recombinant Proteins