Epithelial-mesenchymal transition and the stem cell phenotype.
Epithelial-mesenchymal transition (EMT) is a developmental process in which epithelial cells acquire the motile, migratory properties of mesenchymal cells. In a recent issue of Cell, Mani et al. (2008) show that induction of EMT stimulates cultured breast cells to adopt characteristics of stem cells.
Radisky
Derek C
DC
Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA. radisky.derek@mayo.edu
LaBarge
Mark A
MA
D000818:Animals; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000473:pathology; D051927:CD24 Antigen / Q000378:metabolism; D002465:Cell Movement; D054338:Cell Transdifferentiation; D002471:Cell Transformation, Neoplastic; D004847:Epithelial Cells / Q000166:cytology*; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D008648:Mesoderm / Q000166:cytology / Q000502:physiology; D009361:Neoplasm Invasiveness; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured
D014408:Biomarkers, Tumor; D051927:CD24 Antigen; D018960:Hyaluronan Receptors