Regio- and chemoselective multiple functionalization of pyrimidine derivatives by selective magnesiations using TMPMgCl.LiCl.
Successive regio- and chemoselective magnesiations of pyrimidines using TMPMgCl.LiCl furnish, after trapping with various electrophiles, highly functionalized derivatives in good to excellent yields. Applications to the synthesis of antiviral and anti-inflammatory agents such as p38 and sPLA2 kinase inhibitors are reported.
Department Chemie and Biochemie, Ludwig-Maximilians-Universität, München, Germany.
Marc
M
Mosrin
Paul
P
Knochel
D000468:Alkalies / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents; D008274:Magnesium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D013237:Stereoisomerism
D000468:Alkalies; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D011743:Pyrimidines; C530465:TMPMgCl.LiCl; D008274:Magnesium