[Effect of triptergium wilfordii polyglycosidium on content of Th1 and Th2 in child recurrent nephrotic syndrome].
OBJECTIVE
To study the effect of triptergium wilfordii polyglycosidium on the content of Th1 and Th2 in the treatment child patients of rcurrent nephrotic syndrome.


METHODS
Patients were randomized into treatment group and health group. Sixty-one patients in treatment group were treated with triptergium wilfordii polyglycosidium 1 mg x kg(-1) x d(-1) orally tid for 12 weeks. However, patients in health group was not treated with any drugs. Twelve weeks constituted one course of treatment and the content of IL-12, IL-2, TNF-alpha, IL-13, IL-6, IL-4 in peripheral blood was measured before and behind therapy.


RESULTS
In treatment group, the content of serum cytokines behind therapy was significantly lower than that before therapy, except for IL-12.


CONCLUSIONS
Triptergium wilfordii polyglycosidium could reduce the cytokine level (except for IL-12) of Th1 and Th2, which could lead a therapeutic effect of in the child patients of RNS.
School of Medicine, Jinhua College of Profession and Tecnology, Jinhua 321000, China. ghh53021@163.com
Guo-Hua
GH
Hu
Zhu-Wen
ZW
Yi
Jing-He
JH
Wang
Jing-Chan
JC
Yao
D002648:Child; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006027:Glycosides / Q000494:pharmacology*; D006801:Humans; D018664:Interleukin-12 / Q000378:metabolism; D018793:Interleukin-13 / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000378:metabolism*; D018417:Th1 Cells / Q000187:drug effects* / Q000378:metabolism*; D018418:Th2 Cells / Q000187:drug effects* / Q000378:metabolism*; D029757:Tripterygium / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D006027:Glycosides; D018793:Interleukin-13; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D018664:Interleukin-12; D015847:Interleukin-4