[Systemic metastases of malignant gliomas].
Despite malignant gliomas are highly invasive tumors, extracranial metastatases are extremely rare. We report herein four cases (two glioblastomas, a gliosarcoma and an anaplastic oligodendroglioma) with systemic dissemination occurring 3 to 13 months after surgery. Metastases involved liver, lung, kidney, bone and bone marrow. Survival time after metastatic dissemination ranged from 2 to 5 months for glioblastomas and gliosarcoma. Metastases from the anaplastic oligodendroglioma which displayed 1p and 19q chromosome codeletion, responded to chemotherapy and the patient survived 8 months.
Service de neurologie Mazarin, Groupe hospitalier Pitié-Salpêtrière, 83, bd de l'Hôpital, 75013 Paris. fourtmary@yahoo.fr
Maryam
M
Fourtassi
Dimitri
D
Psimaras
François
F
Ducray
Marc
M
Sanson
D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000556:secondary; D001932:Brain Neoplasms / Q000473:pathology*; D005910:Glioma / Q000556:secondary*; D006801:Humans; D007680:Kidney Neoplasms / Q000556:secondary; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged