Non-engineered, naturally oncolytic herpes simplex virus HSV1 HF-10: applications for cancer gene therapy.
Oncolytic HSV-1 has been developed as a novel anticancer agent. According to the properties and functions of HSV-1 encoded proteins, several genes have been targeted for engineering of oncolytic HSV-1. As a result, a variety of strategies have been applied to the engineering of oncolytic HSV-1. Success in cancer therapy for solid tumors requires a maximal oncolytic effect; however, recombinant HSV-1 that has been adapted to meet neurotoxicity requirements for the treatment of brain tumors may be too highly attenuated for effective use in solid tumors outside the brain. Recently, there has been renewed interest in the high potency of naturally oncolytic viruses. In this review, we will overview the engineered oncolytic HSV developed thus far, as well as its mechanism of selectivity and its mode of spreading within tumors. We also discuss the preclinical and clinical studies of HF-10, a non-engineered oncolytic HSV-1 virus, and its potential for use in cancer gene therapy.
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan. nawa2005@med.nagoya-u.ac.jp
Akihiro
A
Nawa
ChenHong
C
Luo
Lumin
L
Zhang
Yoko
Y
Ushjima
Daisuke
D
Ishida
Maki
M
Kamakura
Yasushi
Y
Fujimoto
Fumi
F
Goshima
Fumitaka
F
Kikkawa
Yukihiro
Y
Nishiyama
D000818:Animals; D002986:Clinical Trials as Topic; D005260:Female; D017781:Genes, Immediate-Early; D005818:Genetic Engineering; D015316:Genetic Therapy / Q000379:methods; D018259:Herpesvirus 1, Human / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D009154:Mutation; D009369:Neoplasms / Q000628:therapy*; D050130:Oncolytic Virotherapy / Q000379:methods*; D014760:Viral Fusion Proteins / Q000235:genetics
D014760:Viral Fusion Proteins