Synthesis, characterization, antioxidant activity and DNA-binding studies of three rare earth (III) complexes with 1-(4-aminoantipyrine)-3-tosylurea ligand.
1-(4-aminoantipyrine)-3-tosylurea (H2L) and its three lanthanide (III) complexes, M(H2L)3 3NO3 [where M=Nd(III), Sm(III) and Eu(III)], have been synthesized and characterized. In addition, the DNA-binding properties of the three complexes have been investigated by UV-vis (ultraviolet and visible) absorption spectroscopy, fluorescence spectroscopy, circular dichroism (CD) spectroscopy, cyclic voltammetry, and viscosity measurements. Results suggest that the three complexes bind to DNA via a groove binding mode. Furthermore, the antioxidant activity (superoxide and hydroxyl radical) of the metal complexes was determined by using spectrophotometer methods in vitro. These complexes were found to possess potent antioxidant activity and be better than standard antioxidants like vitamin C and mannitol.
State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Pin-xian
PX
Xi
Zhi-hong
ZH
Xu
Xiao-hui
XH
Liu
Feng-juan
FJ
Chen
Zheng-zhi
ZZ
Zeng
Xiao-wen
XW
Zhang
Ying
Y
Liu
D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000737:chemistry; D001665:Binding Sites; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004566:Electrodes; D017665:Hydroxyl Radical / Q000737:chemistry; D008024:Ligands; D008674:Metals, Rare Earth / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry; D014783:Viscosity
C540416:1-(4-aminoantipyrine)-3-tosylurea; D000975:Antioxidants; D008024:Ligands; D008674:Metals, Rare Earth; D009942:Organometallic Compounds; D017665:Hydroxyl Radical; D014508:Urea; D004247:DNA; D000983:Antipyrine