[Lung cancer, smoking and genetic modifications].
Lung cancer represents a heterogeneity entity consisting of different histopathologic, clinic and therapeutic subtypes. Smoking is the most well-known risk factor, but the mechanisms of occurrence of lung cancer are not completely understood yet. The effects of smoking are related to the young age of beginning of smoking, the daily dose and the length of smoking, but they also depend of the individual heredity due to the gene polymorphism. Smoking induces several deleterious mechanisms: inactivation of tumor-suppressor genes, activation of proto-oncogenes, increase in telomerase's activity.
Popescu
Iulian
I
Spitalul Clinic Fundeni, Secţia clinică de radiobiologie. popdociul@yahoo.com
D000367:Age Factors; D014408:Biomarkers, Tumor / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D016147:Genes, Tumor Suppressor; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011519:Proto-Oncogenes; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D019098:Telomerase / Q000235:genetics; D013997:Time Factors
D014408:Biomarkers, Tumor; D005819:Genetic Markers; D019098:Telomerase