[Glucocorticoids induced neuropsychiatric disorders].
Glucocorticoids induced psychiatric disorders mostly emerge within the first weeks of corticotherapy. They occur in a variety of qualitatively distinct forms. Manic symptoms are among the most important manifestations of corticosteroids-induced psychiatric toxicity. The incidence of moderate to severe induced reactions is estimated at 5%. Acute cognitive induced disorders are common although moderate. These cognitive alterations specifically affect hippocampal dependant memory process. Chronic cognitive disorders are uncommon, complex, and inconsistent with an isolated alteration of the hippocampal structure. Corticotherapy stop also induced frequent psychiatric withdrawal symptoms, which are mostly depressive symptoms. Occurrence of such symptoms is likely to explain the addictive potentialities of glucocorticoids.
Cornic
Françoise
F
Service de psychiatrie, secteur 13, hôpital Sainte-Anne, Paris. fcornic@gmail.com
Rousset
Inqrid
I
D000208:Acute Disease; D001008:Anxiety Disorders / Q000139:chemically induced / Q000175:diagnosis; D001714:Bipolar Disorder / Q000139:chemically induced / Q000175:diagnosis; D002389:Catatonia / Q000139:chemically induced; D003072:Cognition Disorders / Q000139:chemically induced*; D003221:Confusion / Q000139:chemically induced; D003863:Depression / Q000139:chemically induced* / Q000175:diagnosis; D003937:Diagnosis, Differential; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006624:Hippocampus / Q000187:drug effects; D006801:Humans; D001523:Mental Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D019964:Mood Disorders / Q000139:chemically induced / Q000175:diagnosis; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D012307:Risk Factors; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis; D019966:Substance-Related Disorders / Q000175:diagnosis; D013997:Time Factors
D005938:Glucocorticoids