Target selection: triage in the structural genomics battlefield.
A synopsis of some of the approaches to protein target selection is given, with an emphasis on using web resources to converge on well-ordered, readily crystallizable proteins that are maximally different from known structures. This is illustrated with the genomes of the pathogens causing tuberculosis and sleeping sickness.
School of Chemistry, The University of Manchester, Manchester, UK.
James
J
Raftery
D000818:Animals; D003460:Crystallization; D018360:Crystallography, X-Ray / Q000379:methods; D016208:Databases, Factual; D016680:Genome, Bacterial; D018503:Genome, Protozoan; D023281:Genomics / Q000379:methods*; D008958:Models, Molecular; D009161:Mycobacterium / Q000235:genetics; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D014347:Trypanosoma brucei gambiense / Q000235:genetics; D014353:Trypanosomiasis, African / Q000235:genetics; D014376:Tuberculosis / Q000235:genetics
D011506:Proteins