Gene expression profiling for the diagnosis and prognosis of acute myeloid leukaemia.
Acute myeloid leukaemia (AML) is a heterogeneous disease covering a range of morphological lineages and differentiation stages, but also has number of recurrent chromosomal abnormalities and mutations associated with prognosis. Because of the defined molecular and cytogenetic features, AML has been a focus of gene expression profiling studies and identified differentially expressed genes in the different diagnostic and cytogenetic sub-groups. These studies have lead to the development of expression based classifications and diagnostic chips with further studies aiding prognosis and therapeutic choices.
Mills
Ken
K
CCRCB, Queen's University Belfast, Lisburn Road, Belfast, UK. BT9 7BL. k.mills@qub.ac.uk
D002869:Chromosome Aberrations; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002885:Chromosomes, Human, Pair 16; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D020869:Gene Expression Profiling; D011905:Genes, ras; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000145:classification / Q000175:diagnosis* / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D000090243:Nucleophosmin; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D014178:Translocation, Genetic; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics
D018398:Homeodomain Proteins; D035683:MicroRNAs; D009687:Nuclear Proteins; D000090243:Nucleophosmin; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3