A facile access to pyrroles from amino acids via an aza-Wacker cyclization.
A facile and efficient synthesis of pyrroles from readily available amino acids is described. The key step in the method is an aza-Wacker oxidative cyclization catalyzed by palladium(II)/Cu(OTf)2. A series of pyrroles were obtained by this method under mild conditions.
Zhang
Zuhui
Z
Joint Laboratory of Green Synthetic Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
Zhang
Jintang
J
Tan
Jiajing
J
Wang
Zhiyong
Z
D000596:Amino Acids / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis*
D000596:Amino Acids; D011758:Pyrroles