Antinuclear antibody, is it a risk factor for cerebral ischemia? Magnetic resonance image analysis, a preliminary study.
Magnetic resonance images (MRI) of 103 patients were examined to reveal whether positive antinuclear antibody is a risk factor for cerebral ischemia. The most common MRI formation was the presence of small high-intensity spots. The prevalence of hypertension and diabetes mellitus was significantly low. Although seven cases had no medical risk factors; they showed an abnormal MRI reading. Eleven cases exhibited signs of cerebral stroke. Positive antinuclear antibody cases are suggested to be part of the antiphospholipid antibody syndrome. Various types of cerebral arterial occlusion may occur, showing lacuna, atheroma generation, and a recurrent major vessel occlusion.
Division of Neurosurgery, Stroke Care Unit, Asahikawa Neurosurgical Hospital, 10-21, Asahikawa 078-8220, Japan. yasyas-kuro@umin.ac.jp
Yasutaka
Y
Kurokawa
Eri
E
Ishizaki
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000097:blood*; D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012680:Sensitivity and Specificity
D000974:Antibodies, Antinuclear