[Changes in lacrimal secretion in rabbits according to meibomian glands activity].
OBJECTIVE
The purpose of this issue is to create an experimental animal model of dry eye and study the alteration of lachrymal secretion in time.


METHODS
We used a group of 8 rabbits in which the Meibomian gland orifices of the right eye were individually closed by cauterization, the results being related to the sound left eye.


RESULTS
We studied: the quantitative alteration of the lachrymal secretion using Schirmer 1 test; the alteration of lachrymal film using rose-bengal and fluorescein staining; the variation in tear protein concentration and histopathological changes in conjunctiva.


CONCLUSIONS
We found histopathological changes in conjunctiva and in the lachrymal secretion consisting in conjunctival goblet-ceil density decrease and watery secretion increase, probably due to lachrymal viscosity decrease mechanism.
Clinica Oftalmologica UMF Iuliu Hatieganu, Cluj-Napoca.
Cristina
C
Stan
Oana
O
Visan
O
O
Samoila
Cristina
C
Mogosan
Cristina
C
Craciun
Mihaela
M
Mera
D000818:Animals; D003228:Conjunctiva / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D019793:Fluorescein; D005456:Fluorescent Dyes; D015590:Fluorophotometry; D007765:Lacrimal Apparatus / Q000378:metabolism; D008537:Meibomian Glands / Q000378:metabolism* / Q000473:pathology; D011817:Rabbits; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013666:Tears / Q000737:chemistry / Q000378:metabolism*; D013997:Time Factors
D005456:Fluorescent Dyes; D019793:Fluorescein