Cell intrinsic TGF-beta 1 regulation of B cells.
TGF-beta family cytokines play multiple roles in immune responses. TGF-beta1-null mice suffer from multi-organ infiltration that leads to their premature death. T cells play a central role in the TGF-beta1 phenotype, as deficiency of TGF-beta1 only in T cells reproduces the lethal phenotype. Although it is known that TGF-beta1 controls B cells isotype switch and homeostasis, the source responsible for this control has not been characterized. Because of the major role that T cells play in regulating B cell responses, we addressed the T cell dependency of the TGF-beta1 control of B cells. The analysis of T cell-deficient, TGF-beta1 knockout mice and the production of chimeras in which B but not T cells lacked TGF-beta1 allowed us to show that B cells are controlled in part by cell autonomous production of TGF-beta1.
Aix Marseille Université, Faculté des Sciences de Luminy, Centre d'Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale U631, Marseille, France.
Marilyn J
MJ
Gros
Philippe
P
Naquet
Rodolphe R
RR
Guinamard
D000818:Animals; D000955:Antigens, T-Independent / Q000235:genetics / Q000502:physiology; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism*; D017252:CD3 Complex / Q000235:genetics; D003433:Crosses, Genetic; D006706:Homeostasis / Q000235:genetics / Q000276:immunology; D017578:Immunoglobulin Class Switching / Q000235:genetics; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D011828:Radiation Chimera / Q000235:genetics / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*
D000955:Antigens, T-Independent; D017252:CD3 Complex; C485468:Cd3e protein, mouse; D007132:Immunoglobulin Isotypes; D053773:Transforming Growth Factor beta1