Successful management of refractory neonatal seizures with midazolam.
Seizures are indicative of underlying neurologic dysfunction in neonates. Repeated seizures may be deleterious to the brain even without disturbances of ventilation or perfusion. First-line antiepileptic drugs such as phenobarbital and phenytoin are not very effective in controlling seizures in neonates. Rapid control of status epilepticus with midazolam has been demonstrated in 2 previous studies with complete clinical and electrographic response in neonates who did not respond to phenobarbital and phenytoin. We report our experience with 3 neonates with status epilepticus. Seizures in all 3 neonates did not respond to phenobarbital and phenytoin but responded to midazolam infusion. Midazolam may be considered a safe and effective antiepileptic drug in refractory neonatal seizures of diverse etiologies.
Division of Pediatric Neurology, Department of Pediatrics, New York Presbyterian Hospital-Weill Cornell Medical College, New York, NY 10021, USA.
Deepa
D
Sirsi
Srishti
S
Nangia
Jacqueline
J
LaMothe
Barry E
BE
Kosofsky
Gail E
GE
Solomon
D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000627:therapeutic use*; D020925:Hypoxia-Ischemia, Brain / Q000150:complications; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000150:complications; D008874:Midazolam / Q000009:adverse effects / Q000627:therapeutic use*; D013226:Status Epilepticus / Q000188:drug therapy* / Q000209:etiology; D013290:Streptococcal Infections / Q000150:complications; D013292:Streptococcus agalactiae; D016896:Treatment Outcome
D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D008874:Midazolam