Sumatriptan does not affect arteriovenous oxygen differences in jugular and cubital veins in normal human subjects.
Arteriovenous anastomoses (AVAs) may open up during migraine attacks. In studies with anaesthetized and bilaterally vagosympatectomized pigs, triptans reduce AVA blood flow and increase the arteriovenous O2 difference (AVDO2). To investigate whether subcutaneous sumatriptan 6 mg could induce changes in the AVDO2, we measured the AVDO2 in the external jugular vein in healthy subjects. We also measured the AVDO2 in the internal jugular and cubital veins. There were no changes in AVDO2 after subcutaneous sumatriptan, probably because AVA blood flow is limited in humans with an intact sympathetic nervous system.
Danish Headache Centre and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark.
T
T
Wienecke
J M
JM
Hansen
J
J
Petersen
K S
KS
Olsen
M
M
Ashina
P
P
Tfelt-Hansen
D000328:Adult; D001163:Arteriovenous Anastomosis / Q000187:drug effects*; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007601:Jugular Veins / Q000187:drug effects*; D008297:Male; D010100:Oxygen / Q000097:blood*; D012016:Reference Values; D012039:Regional Blood Flow / Q000187:drug effects; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage*; D018170:Sumatriptan / Q000008:administration & dosage*; D055815:Young Adult
D017366:Serotonin Receptor Agonists; D018170:Sumatriptan; D010100:Oxygen