Malakoplakia of the spleen: a case report.
Malakoplakia is an uncommon chronic inflammatory disorder, which is characterized by the presence of histiocytes containing concentric concretions known as Michaelis-Gutmann bodies in a background of mixed inflammation. The urinary tract is the most commonly involved site. However, malakoplakia can be found in a wide range of other organs throughout the body. Its occurrence has been attributed to a defect in the bactericidal capacity of phagocytic cells, and it is usually seen in patients with some degree of immunologic compromise. A case of malakoplakia of the spleen in a patient with Crohn's disease is reported in this article.
Pathology, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA. wgreaves@lifespan.org
Wesley O
WO
Greaves
Li J
LJ
Wang
D000038:Abscess / Q000150:complications; D000328:Adult; D001249:Asthma / Q000150:complications; D003424:Crohn Disease / Q000150:complications; D004927:Escherichia coli Infections / Q000150:complications; D005764:Gastroesophageal Reflux / Q000150:complications; D006406:Hematoma / Q000150:complications; D006801:Humans; D008287:Malacoplakia / Q000150:complications / Q000473:pathology*; D008297:Male; D011565:Psoriasis / Q000150:complications; D013158:Splenic Diseases / Q000150:complications / Q000473:pathology*; D013203:Staphylococcal Infections / Q000150:complications