[Proton magnetic resonance spectroscopy in postoperative radiochemotherapy of patients with cerebral glioblastoma].
The paper discusses the data from dynamic follow-up of immunohistologically confirmed glioblastomas of the brain using proton magnetic resonance imaging (+H MRI) (25). Study was undertaken before and after therapy and resumed for 6-8 months after. Cholin concentration peaks and N-acetyl-aspartate decrease in gliomas appeared to be higher than those in anaplastic astrocytomas. Moreover, N-acetyl-aspartate peaks were obliterated by large necrotic areas in glioblastoma. Instead, lipid and lactate concentrations peaked thus suggesting pathological changes. A necrotic area developed in the course of radiochemotherapy involving peaks for wide profile of lipid and lactate concentrations coupled with lowered levels of other metabolites.
A V
AV
Pozdniakov
A V
AV
Kartashev
L A
LA
Tiutin
V M
VM
Vinogradov
K M
KM
Pozharisskiĭ
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011522:Protons; D018714:Radiotherapy, Adjuvant
D011522:Protons