Adenomyomatous hamartoma of lung mimicking benign mucinous tumor in fine needle aspiration biopsy: a case report.
BACKGROUND
Typical cytologic features of pulmonary hamartoma (PH) are usually smears of hyaline cartilage, fibrous tissue, smooth muscle, adipocytic components and respiratory epithelium. Cytologic features of adenomyomatous hamartoma, a special variant of PH, are not documented in the literature and are confused with epithelial neoplasm in the case of sparse stromal cellularity.


METHODS
A 59-year-old man presented with a solitary pulmonary nodule by chest radiograph at his routine health examination. Fine needle aspiration biopsy (FNAB) revealed numerous mucinous epithelial cells presenting predominantly in cohesive cellular sheets that suggested benign mucinous epithelial lesion. The patient underwent surgery for the tumor, and it was histologically proven to be an adenomyomatous hamartoma.


CONCLUSIONS
An unusual type of PH could lead to misdiagnosis by FNAB in the case of few stromal components. This case demonstrates the wide spectrum of PH in FNAB and led us to consider PH as a differential diagnosis despite lack of chondromyxoid stromal components.
Jin
Min-Sun
MS
Department of Pathology, Thoracic Surgery, Internal Medicine, Korea Cancer Center Hospital, Korean Institute of Radiological and Medical Science, Seoul, Korea.
Ha
Hwa-Jeong
HJ
Baek
Hee Jong
HJ
Lee
Jae Cheol
JC
Koh
Jae Soo
JS
D044963:Biopsy, Fine-Needle; D018277:Carcinoma, Mucoepidermoid / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D006222:Hamartoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020775:Thoracic Surgery, Video-Assisted; D016896:Treatment Outcome