Acute renal insufficiency, supraventricular tachycardia, and confusion after recombinant human bone morphogenetic protein-2 implantation for lumbosacral spine fusion.
The authors report on a case of a patient who received recombinant human bone morphogenetic protein-2 (rhBMP-2) to augment spinal fusion for the first and third of 3 lumbosacral fusion surgeries. After receiving rhBMP-2 the first time, the patient became febrile and developed mild acute renal insufficiency and transient supraventricular tachycardia (SVT). The second operation was complicated only by perioperative fever. When the patient received rhBMP-2 again during the third operation, he developed fever, acute oliguric renal insufficiency, symptomatic SVT with hypoxemia, confusion, and joint pain. No clear cause of these problems was identified; however serum analysis revealed the presence of an antibody to rhBMP-2. The authors discuss potential mechanisms for the patient's putative reaction to rhBMP-2, as the findings from a literature review suggest this is the first such reaction to be reported.
Department of Neurosurgery, New York University School of Medicine, New York, New York, USA.
Yaron A
YA
Moshel
Edgar I
EI
Hernandez
Li
L
Kong
Chuanju
C
Liu
Uzma
U
Samadani
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000906:Antibodies / Q000097:blood; D018771:Arthralgia / Q000139:chemically induced; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000009:adverse effects* / Q000276:immunology; D003221:Confusion / Q000139:chemically induced*; D005334:Fever / Q000139:chemically induced; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced; D007074:Immunoglobulin G / Q000097:blood; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012447:Sacrum / Q000601:surgery*; D013123:Spinal Fusion / Q000379:methods*; D013617:Tachycardia, Supraventricular / Q000139:chemically induced*; D016212:Transforming Growth Factor beta / Q000009:adverse effects* / Q000276:immunology
D000906:Antibodies; C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D007074:Immunoglobulin G; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta