Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale for host susceptibility to disease.
Bovine leukemia virus (BLV) is a deltaretrovirus that infects and induces accumulation of B-lymphocytes in the peripheral blood and lymphoid tissues of cattle, leading to leukemia/lymphoma. BLV can also be experimentally transmitted to sheep, in which disease appears earlier and at higher frequencies. Abnormal accumulation of leukemic B-lymphocytes results from an alteration of different parameters that include cell proliferation and death as well as migration to lymphoid tissues. Interestingly, B lymphocyte turnover is increased in BLV-infected sheep but reduced in cattle, revealing a potential relationship between cell kinetics and disease progression.
Florins
Arnaud
A
Gembloux Agricultural University, Cellular and Molecular Biology, Gembloux, Belgium. florins.a@fsagx.ac.be
Boxus
Mathieu
M
Vandermeers
Fabian
F
Verlaeten
Olivier
O
Bouzar
Amel-Baya
AB
Defoiche
Julien
J
Hubaux
Roland
R
Burny
Arsène
A
Kettmann
Richard
R
Willems
Luc
L
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002417:Cattle; D016583:Enzootic Bovine Leukosis / Q000235:genetics / Q000276:immunology / Q000473:pathology* / Q000821:virology; D016158:Genes, p53; D001909:Leukemia Virus, Bovine / Q000276:immunology*; D008213:Lymphocyte Activation; D008221:Lymphoid Tissue / Q000276:immunology / Q000473:pathology; D012756:Sheep; D012757:Sheep Diseases / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000821:virology*