Analysis of TP53 codon 72 polymorphism in HPV-positive and HPV-negative penile carcinoma.
The association of the p53 polymorphism at codon 72 and susceptibility to develop human papillomavirus (HPV)-related cancer has been investigated in several studies with controversial results. In this study, 78 penile squamous cell carcinoma biopsies (n=17 from Uganda, n=61 from Italy) and blood samples from 150 healthy controls (n=57 from Uganda, n=93 from Italy) have been analyzed for the arginine and proline allele distribution. Among Ugandan cases the heterozygous, proline homozygous and arginine homozygous genotype frequency was 41.2%, 52.9% and 5.9%, respectively, and among controls was 40.3%, 54.4%, and 5.3%, respectively (P=0.9917). Conversely, among Italian cases genotype distribution was 42.6%, 4.9%, and 52.5%, and among controls was 34.4%, 7.5%, and 58.1%, respectively (P=0.5343). No significant differences in arginine and proline allele distribution were observed when the cases were stratified by HPV status. Therefore, no evidence of association between homozygosity for p53 arginine and HPV-related or HPV-unrelated penile squamous cell carcinoma was observed neither among Ugandan nor among Italian populations.
Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fondazione Pascale, Cappella Cangiani, 80131 Naples, Italy.
Maria Lina
ML
Tornesello
Maria Luisa
ML
Duraturo
Valentina
V
Guida
Simona
S
Losito
Gerardo
G
Botti
Silvana
S
Pilotti
Bernardina
B
Stefanon
Giuseppe
G
De Palo
Luigi
L
Buonaguro
Franco M
FM
Buonaguro
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000208:ethnology / Q000235:genetics* / Q000821:virology; D003062:Codon; D016158:Genes, p53; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D010412:Penile Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000821:virology; D011110:Polymorphism, Genetic; D014454:Uganda
D003062:Codon