Is the application of prostaglandin E1 effective for the treatment of sudden hearing loss? An evidence-based meta-analysis.
Microvascular dysfunction in the cochlea has been considered the major cause of sudden hearing loss (SHL). For some time, prostaglandin E(1) (PGE(1)), an effective vasodilator, has been used to treat patients with SHL, however the benefits of this therapy remain unclear. The present study assessed the efficacy of PGE(1) on SHL via a quantitative meta-analysis of 13 randomized controlled studies. The pooled odds ratio was 1.95 (95% confidence interval: 1.53, 2.50) and the test for overall effect (Z-value) was 5.31 (P < 0.00001), suggesting that PGE(1) is an effective and promising strategy for the treatment of SHL.
Zhuo
Xian-Lu
XL
Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, China; Guiyang Medical College, Guiyang, China.
Wang
Yan
Y
Zhuo
Wen-Lei
WL
Zhang
Xue-Yuan
XY
D000527:Alprostadil / Q000627:therapeutic use*; D015982:Bias; D016206:Databases, Bibliographic; D019317:Evidence-Based Medicine; D003639:Hearing Loss, Sudden / Q000188:drug therapy*; D006801:Humans; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents; D000527:Alprostadil