Oral immunization with Salmonella harboring a Sm14-based DNA vaccine does not protect mice against Schistosoma mansoni infection.
The protection against Schistosoma mansoni infection was evaluated in SWISS mice orally vaccinated with an attenuated strain of Salmonella carrying a Sm14-based DNA vaccine. Although this formulation was not able to afford a reduction in the worm burden, a non-antigen-specific decrease in schistosome-induced granulomatous reaction was verified in livers of mice that received Salmonella.
Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte - MG, Brazil.
Luis G C
LG
Pacheco
Vítor L T
VL
Mati
Thiago L P
TL
Castro
Fernanda A
FA
Dorella
Sérgio C
SC
Oliveira
Anderson
A
Miyoshi
Alan L
AL
de Melo
Vasco
V
Azevedo
D000284:Administration, Oral; D000818:Animals; D050612:Fatty Acid Transport Proteins / Q000008:administration & dosage / Q000235:genetics*; D005260:Female; D006099:Granuloma / Q000469:parasitology / Q000473:pathology / Q000517:prevention & control; D015801:Helminth Proteins / Q000008:administration & dosage / Q000235:genetics*; D007114:Immunization; D008099:Liver / Q000469:parasitology / Q000473:pathology; D051379:Mice; D010957:Plasmids / Q000235:genetics; D012486:Salmonella typhimurium / Q000235:genetics*; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000469:parasitology / Q000473:pathology / Q000517:prevention & control*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000235:genetics; D019444:Vaccines, DNA / Q000008:administration & dosage*
D050612:Fatty Acid Transport Proteins; D015801:Helminth Proteins; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA; C068709:SM14 protein, Schistosoma mansoni