Secretory outposts for the local processing of membrane cargo in neuronal dendrites.
The large size and geometric complexity of neuronal dendrites necessitate specialized mechanisms to both deliver postsynaptic cargo over extended distances and regulate dendritic composition on a submicron scale. Despite the fundamental importance of membrane trafficking in dendrite growth, synapse formation and plasticity, the organelles and cellular rules governing postsynaptic trafficking are only now emerging. Here we review what is currently known about dendritic secretory organelles and their role in the development, maintenance and plasticity of postsynaptic compartments.
Department of Neurobiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.
Cyril
C
Hanus
Michael D
MD
Ehlers
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D003712:Dendrites / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology; D015388:Organelles / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D017510:Protein Folding; D021381:Protein Transport; D055571:Secretory Pathway / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
D008565:Membrane Proteins