Usefulness of the ratio of transmitral E wave velocity to isovolumic relaxation flow propagation velocity for predicting left ventricular end-diastolic pressure.
Transmitral E wave velocity was reported to be positively related to left ventricular (LV) filling pressure and negatively related to LV relaxation constant, and isovolumic relaxation flow propagation velocity (IRFPV) was proven recently to be negatively related to LV relaxation constant and independent of preload alterations. Therefore, the combination index, E/IRFPV, may eliminate the influence of LV relaxation and bring the LV filling pressure into focus. However, it is unknown whether E/IRFPV is a useful index in prediction of LV filling pressure. The aim of this study is to evaluate the correlation between E/IRFPV and LV end-diastolic pressure (LVEDP). Forty-three patients with suspected coronary artery disease who underwent a Doppler echocardiographic study and cardiac catheterization were included. LVEDP was determined by a micromanometer-tipped catheter. In a univariate analysis, LVEDP had a positive correlation with left atrial dimension, LV end-diastolic dimension, LV end-systolic dimension, the ratio of E to E wave propagation velocity (EPV) (r = 0.408, p = 0.007), the ratio of E to early diastolic mitral annular velocity (Ea) (r = 0.439, p = 0.003) and E/IRFPV (r = 0.686, p < 0.001). It had a negative correlation with diastolic blood pressure, E wave deceleration time, LV ejection fraction, EPV, Ea and IRFPV. After stepwise multiple linear regression analysis, only the E/IRFPV was the independent predictor of LVEDP (beta = 0.667, p < 0.001). In conclusion, E/IRFPV is a useful parameter in prediction of LVEDP.
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ho-Ming
HM
Su
Tsung-Hsien
TH
Lin
Chee-Siong
CS
Lee
Chien-Tsai
CT
Lin
Min-Hua
MH
Tang
Tan-Tze
TT
Chin
Wen-Ter
WT
Lai
Sheng-Hsiung
SH
Sheu
Wen-Chol
WC
Voon
D000368:Aged; D006328:Cardiac Catheterization / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015150:Echocardiography, Doppler / Q000379:methods; D018618:Echocardiography, Doppler, Color / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left; D017725:Ventricular Pressure / Q000502:physiology