Voxel-based morphometry study on brain structure in children with high-functioning autism.
Earlier studies have suggested abnormal brain volumes in autism, but inconsistencies exist. Using voxel-based morphometry, we compared global and regional brain volumes in 17 high-functioning autistic children with 15 matched controls. We identified significant reduction in left white matter volume and white/gray matter ratio in autism. Regional brain volume reductions were detected for right anterior cingulate, left superior parietal lobule white matter volumes, and right parahippocampal gyrus gray matter volume, whereas enlargements in bilateral supramarginal gyrus, right postcentral gyrus, right medial frontal gyrus, and right posterior lobe of cerebellum gray matter in autism. Our findings showed global and regional brain volumes abnormality in high-functioning autism.
Key Laboratory of Child Development and Learning Science (Southeast University), Ministry of Education, Nanjing Medical University, Nanjing, China. kexynj@hotmail.com
Xiaoyan
X
Ke
Shanshan
S
Hong
Tianyu
T
Tang
Bing
B
Zou
Huiguo
H
Li
Yueyue
Y
Hang
Zhenyu
Z
Zhou
Zongcai
Z
Ruan
Zuhong
Z
Lu
Guotai
G
Tao
Yijun
Y
Liu
D000293:Adolescent; D001321:Autistic Disorder / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D002648:Child; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male