Fatal neonatal myocarditis caused by a recombinant human enterovirus-B variant.
We report a case of fatal myocarditis in a newborn infant who was infected with a human enterovirus detected by throat culture and RT-PCR for viral RNA in plasma. Whole genome sequence analysis revealed the virus to be a genomic chimera that likely arose from recombination between coxsackievirus B3 and two recently identified enteroviruses, EV 86 and EV97.
Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. pkrogstad@mednet.ucla.edu
Paul
P
Krogstad
Rebecca
R
Hammon
Nancy
N
Halnon
J Lindsay
JL
Whitton
D029822:Enterovirus B, Human / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000175:diagnosis*; D017809:Fatal Outcome; D016679:Genome, Viral; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008969:Molecular Sequence Data; D009205:Myocarditis / Q000821:virology*; D010614:Pharynx / Q000821:virology; D010949:Plasma / Q000821:virology; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D014776:Virus Cultivation
D012367:RNA, Viral