Hematopoietic lineage commitment: miRNAs add specificity to a widely expressed transcription factor.
MicroRNAs are important regulators of normal and malignant hematopoiesis. A paper by Lu et al. in this issue of Developmental Cell demonstrates how one microRNA, miR-150, plays a critical role in commitment of the erythroid-megakaryocyte progenitor by modulating the level of the widely expressed transcription factor MYB (or c-Myb).
García
Paloma
P
Institute of Biomedical Research, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, UK.
Frampton
Jon
J
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D041905:Erythroid Cells / Q000166:cytology / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism*; D008533:Megakaryocytes / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D020598:Proto-Oncogene Proteins c-myb / Q000235:genetics / Q000378:metabolism*
D035683:MicroRNAs; D020598:Proto-Oncogene Proteins c-myb