Spliceosomal immunophilins.
The spliceosome is a dynamic, macromolecular complex, which removes non-protein-coding introns from pre-mRNA to form mature mRNA in a process known as splicing. This ribonucleoprotein assembly is comprised of five uridine-rich small nuclear RNAs (snRNAs) as well as over 300 proteins. In humans, several of the known proteinaceous splicing factors are members of the immunophilin superfamily. Immunophilins are peptidyl-prolyl cis-trans isomerases that catalyze the conversion of proteins from cis to trans at Xaa-Pro bonds. Our review of the data indicates that some members of this protein family are activators of spliceosomal proteins by way of folding and transport.
Mesa
Annia
A
Florida International University, Department of Biological Sciences, University Park, 11200 SW 8th Street, OE 304, Miami, FL 33199, United States.
Somarelli
Jason A
JA
Herrera
Rene J
RJ
D005656:Fungal Proteins / Q000502:physiology; D006801:Humans; D020104:Immunophilins / Q000502:physiology*; D012326:RNA Splicing; D016601:RNA-Binding Proteins / Q000378:metabolism; D017411:Ribonucleoproteins, Small Nuclear / Q000737:chemistry; D017381:Spliceosomes / Q000201:enzymology*
D005656:Fungal Proteins; D016601:RNA-Binding Proteins; D017411:Ribonucleoproteins, Small Nuclear; D020104:Immunophilins