Congenital toxoplasmosis: specific IgG subclasses in mother/newborn pairs.
Anti-Toxoplasma gondii antibodies of all IgG subclasses were studied in mother/newborn pairs. IgG1 in the mothers and IgG3 in the newborns were related to offspring clinical problems; IgG2 and IgG3 in the babies were markers of vertical transmission, and IgG4 in mothers or children were associated to clinical problems. IgG subclasses may be markers of congenital infection or clinical outcome.
Cañedo-Solares
Irma
I
Inmunología Experimental, Subdirección de Medicina Experimental, Instituto Nacional de Pediatría, Secretaría de Salud, México DF.
Galván-Ramírez
María de la Luz
Mde L
Luna-Pastén
Héctor
H
Rodríguez Pérez
Laura Rocío
LR
Ortiz-Alegría
Luz Belinda
LB
Rico-Torres
Claudia Patricia
CP
Vela-Amieva
Marcela
M
Pérez-Andrade
Martha
M
Figueroa-Damián
Ricardo
R
Correa
Dolores
D
D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D015415:Biomarkers; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007231:Infant, Newborn; D009035:Mothers; D011379:Prognosis; D014122:Toxoplasma / Q000276:immunology*; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis* / Q000276:immunology*
D000913:Antibodies, Protozoan; D015415:Biomarkers; D007074:Immunoglobulin G