CCN3-mutant mice are distinct from CCN3-null mice.
A recent manuscript reported phenotypic alterations associated to the expression of a CCN3 protein deleted for the Von Willebrand type C repeat that is common to the various members of the CCN family of proteins. In this comment, the biological significance of these alterations is briefly discussed.
Perbal
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Department of Dermatology, University of Michigan Medical School, Medical Science I, 1150 W. Medical Center Dr., Ann Arbor, MI, 48109-0609, USA, perbalbernard@yahoo.com.