Advances in basic and clinical immunology in 2007.
In 2007, there was significant progress in the area of basic immunology, including investigations that led to a better understanding of the function of antigen-presenting cells, such as the secretion of cytokines that inhibit or induce allergic inflammation on antigen stimulation. Mechanisms of IgE function were better characterized, and the clonality of IgE-producing B cells in allergic responses of monosensitized patients was demonstrated. The hygiene hypothesis was re-examined, with most of the evidence suggesting that the increase of atopy prevalence is best explained by the absence of T(H)1 responses rather than the absence of regulatory T cells. The effects of the environment in the allergic inflammation of the lung received new emphasis. Similar progress took place in the area of clinical immunology. Immune adverse reactions to drugs, such as the toxicity of carbamazepine-specific T cells and the safety and efficacy of drugs for the treatment of hereditary angioedema, were better characterized. There were advances in the molecular characterization of primary immunodeficiencies and their management, remarkably the discovery of signal transducer and activator of transcription 3 gene mutations as the cause of hyper-IgE syndrome. Long-term outcomes of bone marrow transplantation for severe combined immunodeficiencies confirmed the efficacy of this therapy.
Chinen
Javier
J
Department of Pediatrics, Allergy and Immunology Section, Baylor College of Medicine, Houston, Tex 77030, USA. jxchinen@texaschildrenshospital.org
Shearer
William T
WT
D017951:Antigen Presentation; D001402:B-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007107:Immune System / Q000502:physiology*; D007073:Immunoglobulin E / Q000276:immunology / Q000378:metabolism; D007153:Immunologic Deficiency Syndromes / Q000276:immunology* / Q000378:metabolism; D008415:Mastocytosis / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines; D007073:Immunoglobulin E