Influence of estrogen and androgen on the outcome of liver transplantation.
OBJECTIVE
To assess influence of sex hormone on outcome of orthotropic liver transplantation (OLT).


METHODS
Adult female Wistar rats were used as donors and male Wistar rats as recipients. Two experimental series were established. The first series consisted of the orchectomized (ORC) group. 17beta-estradiol (E2) treated-ORC group and recipient Sham-ORC group; the second series consisted of the ovariectomized (OVX) group, dihydrotestosterone (DHT)-treated OVX group and donor Sham-OVX group. Recipients were sacrificed on postoperative day 7 (POD 7); the survival rate (SVR), histomorphological damage score of liver, graft-recipient weight ratio (GRWR) and the levels of alanine aminotransferase (ALT), alkaline phosphatase (AKP) and albumin (ALB) on POD 7 were detected.


RESULTS
The histomorphological damage score and the level of ALT and AKP in the E2-treated ORC group, OVX group and DHT-treated OVX group was significantly lower compared with their respective sham group (P<0.05).


CONCLUSIONS
Estrogen in recipient rats was responsible for the observed beneficial effects of liver transplantation, but at the same time, influence on liver of estrogen for a long time decreased the adaptability of graft to environment change. In contrary, androgen had less influence than estrogen.
Department of General Surgery, Qilu Hospital, Shan Dong University, Jinan 250012, China.
Bin
B
Jin
Chong Zhong
CZ
Liu
San Yuan
SY
Hu
Tian Tian
TT
Wang
Lei
L
Wang
Xu Sheng
XS
Jiang
Eldo E
EE
Frezza
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000728:Androgens / Q000502:physiology*; D000818:Animals; D004967:Estrogens / Q000502:physiology*; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D008099:Liver / Q000473:pathology; D016031:Liver Transplantation / Q000473:pathology / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014019:Tissue Donors; D016896:Treatment Outcome
D000728:Androgens; D004967:Estrogens; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase