N-phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats.
The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg(-1) body mass) once a day for seven days, iron serum level decreased by 21%, whereas the iron value dropped by 32% in female rats (1.5 mg kg(-1) body mass). The results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible.
Matijević-Sosa
Julija
J
Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia. jmatijevic@pharma.hr
Samarzija
Ita
I
Honović
Lorena
L
Jurisić
Blazenka
B
D000818:Animals; D004334:Drug Administration Schedule; D005260:Female; D005293:Ferritins / Q000097:blood; D005998:Glycine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007501:Iron / Q000097:blood*; D007502:Iron Chelating Agents / Q000008:administration & dosage / Q000494:pharmacology*; D019190:Iron Overload / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014168:Transferrin / Q000378:metabolism
D006877:Hydroxamic Acids; D007502:Iron Chelating Agents; D014168:Transferrin; C008899:N-phthalylglycine; D005293:Ferritins; D007501:Iron; D005998:Glycine