[Effect of Na(+), K(+)-pump inhibitors on the sensory ganglia neurite growth].
Inhibitors of Na(+), K(+)-pump belonging to the class of cardiac glycosides were investigated in organotypic tissue culture of dorsal root ganglia cells of 10-12 days old chicken embryos. The data obtained show that the application of cardiac glycosides (strophantin K and digoxin) in a wide range of concentrations controls the neurite growth in sensory neurons in the dose-dependent manner. It was shown, that at the concentrations of cardiac glycoside exceeding 1 x 10(-6) M the growth of neurites was totally inhibited. Our data indicate that cardiac glycoside have the down-regulation effect on the neurite growth. The data obtained indicate that the Na(+), K(+)-ATPase is involved in the control of the process of neurite growth as a signal transducer.
V A
VA
Penniiaĭnen
E V
EV
Lopatina
V A
VA
Tsyrlin
B V
BV
Krylov
D000818:Animals; D002642:Chick Embryo; D004077:Digoxin / Q000494:pharmacology*; D017950:Ganglia, Sensory / Q000187:drug effects* / Q000196:embryology / Q000502:physiology; D016501:Neurites / Q000187:drug effects* / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013328:Strophanthins / Q000494:pharmacology*
D013328:Strophanthins; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase; C029082:strophanthin K