Towards noninvasive molecular fluorescence imaging of the human brain.
Fluorescence molecular brain imaging is a new modality allowing the detection of specific contrast agents down to very low concentration ranges (picomolar) in disease models. Here we demonstrate a first noninvasive application of fluorescence imaging in the human brain, where concentrations down to about 100 nM of a nonspecific dye were detected. We argue that due to its high sensitivity, optical molecular imaging of the brain is feasible, which - together with its bedside applicability - makes it a promising technique for use in patients.
Clinic of Neurology, Charité - Universitatsmedizin Berlin, Berlin, Germany. jens.steinbrink@charite.de
J
J
Steinbrink
A
A
Liebert
H
H
Wabnitz
R
R
Macdonald
H
H
Obrig
A
A
Wunder
R
R
Bourayou
T
T
Betz
J
J
Klohs
U
U
Lindauer
U
U
Dirnagl
A
A
Villringer
D000818:Animals; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D005453:Fluorescence; D006801:Humans; D051379:Mice; D008967:Molecular Biology / Q000379:methods; D012680:Sensitivity and Specificity; D019265:Spectroscopy, Near-Infrared / Q000379:methods*