[Osmotically controlled oral drug delivery systems: an update review].
Osmotically controlled oral drug delivery systems (OCODDSs) utilize osmotic pressure for controlled delivery of active agents. The release of drugs from osmotic systems is governed by various formulations and processing factors such as solubility and pressure of the core components, properties of the semi-permeable membrane. In the present review, the references on OCODDSs have systematically been summarized in the following aspects: prescription design, industrial processing and equipments, methods for quality evaluation, and general situation of application. Prospect of applying the osmotic-pump technology into Chinese patent drugs is also discussed.
College of Pharmaceutics, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. wangwenpingg@sina.com
Wen-Ping
WP
Wang
Xiu-Qiong
XQ
Xie
Da-Jian
DJ
Yang
Shi-Lin
SL
Chen
D000284:Administration, Oral; D016503:Drug Delivery Systems / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage; D009997:Osmotic Pressure
D004365:Drugs, Chinese Herbal