N-phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats.
The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg(-1) body mass) once a day for seven days, iron serum level decreased by 21%, whereas the iron value dropped by 32% in female rats (1.5 mg kg(-1) body mass). The results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible.
Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia. jmatijevic@pharma.hr
Julija
J
Matijević-Sosa
Ita
I
Samarzija
Lorena
L
Honović
Blazenka
B
Jurisić
D000818:Animals; D004334:Drug Administration Schedule; D005260:Female; D005293:Ferritins / Q000097:blood; D005998:Glycine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007501:Iron / Q000097:blood*; D007502:Iron Chelating Agents / Q000008:administration & dosage / Q000494:pharmacology*; D019190:Iron Overload / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014168:Transferrin / Q000378:metabolism
D006877:Hydroxamic Acids; D007502:Iron Chelating Agents; D014168:Transferrin; C008899:N-phthalylglycine; D005293:Ferritins; D007501:Iron; D005998:Glycine