[Disturbed metabolism of gastric mucosa DNA precursors as prognosticator of neoplastic transformation of gastric ulcer].
Levels were assayed and compared of metabolic enzymes--thymidine and adenosine--in gastric mucosa tissues and blood serum from patients with gastric ulcer disease and gastric cancer (age--30-60 yrs). Enzymatic levels matched to the highest degree in cases of ulcer disease aggravated by chronic atrophic gastritis and precancerous alterations (dysplasia, metaplasia). Elevated concentrations of thymidine kinase and phosphorylase and adenosine desaminase were identified both at foci of ulceration (p > 0.001, p > 0.05, respectively) and in blood serum in all age brackets. Moreover, blood serum assay confirmed the view that changes in serum enzyme levels are suggestive of those in tissue enzymatic profile. Our data established a direct correlation between accumulated effect of level changes, on the one hand, and risk of neoplastic transformation of gastric mucosa in ulcer patients, on the other.
B G
BG
Borzenko
E M
EM
Bakurova
D000243:Adenosine Deaminase / Q000097:blood / Q000378:metabolism; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic; D002908:Chronic Disease; D004273:DNA, Neoplasm / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D006005:Phosphorylases / Q000097:blood / Q000378:metabolism; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000097:blood / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D013276:Stomach Ulcer / Q000097:blood / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D013937:Thymidine Kinase / Q000097:blood / Q000378:metabolism
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D006005:Phosphorylases; D013937:Thymidine Kinase; D000243:Adenosine Deaminase