Proteins: coexistence of stability and flexibility.
We introduce an equation for protein native topology based on recent analysis of data from the Protein Data Bank and on a generalization of the Landau-Peierls instability criterion for fractals. The equation relates the protein fractal dimension df, the spectral dimension ds, and the number of amino acids N. Deviations from the equation may render a protein unfolded. The fractal nature of proteins is shown to bridge their seemingly conflicting properties of stability and flexibility. Over 500 proteins have been analyzed (df, ds, and N) and found to obey this equation of state.
Reuveni
Shlomi
S
School of Chemistry, Tel-Aviv University, Tel-Aviv 69978, Israel.
Granek
Rony
R
Klafter
Joseph
J
D017709:Fractals; D008956:Models, Chemical; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*
D011506:Proteins