Cardiovascular autonomic dysfunction in patients with movement disorders.
Autonomic dysfunction is common in parkinsonian syndromes, particularly those involving dysregulation of alpha-synuclein, and may result from neurodegeneration in autonomic regulatory regions of the brain or peripherial autonomic ganglia. The most limiting cardiovascular autonomic dysfunction in these diseases is orthostatic hypotension, which is particularly prominent in multiple system atrophy. Postprandial hypotension and supine hypertension, as well as dopaminergic therapy, often complicate the management of orthostatic hypotension in patients with parkinsonian syndromes.
Walter
Benjamin L
BL
Center for Neurological Restoration, Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. walterb@ccf.org
D001341:Autonomic Nervous System / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D020961:Lewy Body Disease / Q000503:physiopathology; D009069:Movement Disorders / Q000175:diagnosis / Q000503:physiopathology*; D019578:Multiple System Atrophy / Q000503:physiopathology; D010300:Parkinson Disease / Q000503:physiopathology; D012307:Risk Factors