Tuneable pseudorotaxane formation between a biotin-avidin bioconjugate and CBPQT4+.
A biotinylated 1,5-dialkoxynaphthalene derivative has been shown to have the ability to bind strongly to avidin and thus act as an artificial binding site for cyclobis(paraquat-p-phenylene) thereby facilitating the formation of a tuneable pseudorotaxane-based bioconjugate.
Caldwell
Stuart T
ST
Glasgow Centre for Physical Organic Chemistry, WestCHEM, Department of Chemistry, Joseph Black Building, University of Glasgow, Glasgow, UK G12 8QQ.
Cooke
Graeme
G
Cooper
Alan
A
Nutley
Margaret
M
Rabani
Gouher
G
Rotello
Vincent
V
Smith
Brian O
BO
Woisel
Patrice
P
D001360:Avidin / Q000737:chemistry*; D001665:Binding Sites; D001710:Biotin / Q000737:chemistry*; D004583:Electrons; D008956:Models, Chemical; D009281:Naphthalenes / Q000737:chemistry*; D010269:Paraquat / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D043862:Rotaxanes / Q000138:chemical synthesis*; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors
D009281:Naphthalenes; D043862:Rotaxanes; D001360:Avidin; D001710:Biotin; D010269:Paraquat