Preparation and characterization of modified hydroxyapatite particles by heparin.
Heparin-modified hydroxyapatite (HAP-HP) particles were prepared by an in situ coprecipitation method and were characterized by Fourier transform infrared spectrometry, x-ray diffraction and transmission electron microscopy. The heparin content in the particles was determined by a colorimetric assay and energy dispersive x-ray spectroscopy. Final results indicated that the crystallinity and crystal size decreased as both the Ca/P molar ratio and sulfur content increased by adding heparin. Blood compatibility of the HAP-HP particles was evaluated by activated partial thrombin time and prothrombin time. The clotting time of HAP-HP was prolonged remarkably compared with that of HAP. Above all, this novel HAP-HP material can be potentially applied as compatible blood materials for drug carriers of intravenous injection and artificial blood vessels.
Zhao
D M
DM
The Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China.
Wang
Y X
YX
Chen
Z Y
ZY
Xu
R W
RW
Wu
G
G
Yu
D S
DS
D000925:Anticoagulants / Q000008:administration & dosage / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D001777:Blood Coagulation / Q000187:drug effects*; D004343:Drug Implants / Q000008:administration & dosage* / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D006493:Heparin / Q000008:administration & dosage* / Q000737:chemistry*; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D014914:Whole Blood Coagulation Time
D000925:Anticoagulants; D001672:Biocompatible Materials; D004343:Drug Implants; D006493:Heparin; D017886:Durapatite