Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes.
Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.
Vela
Eric M
EM
Department of Pathology, Institute for Human Infections and Immunity, The University of Texas Medical Branch, Galveston, TX, USA. velae@battelle.org
Colpitts
Tonya M
TM
Zhang
Lihong
L
Davey
Robert A
RA
Aronson
Judith F
JF
D000818:Animals; D018050:Arenavirus / Q000502:physiology*; D002522:Chlorocebus aethiops; D034285:Dynamin II / Q000378:metabolism*; D011992:Endosomes / Q000737:chemistry / Q000821:virology*; D006863:Hydrogen-Ion Concentration; D014709:Vero Cells; D053586:Virus Internalization; D020691:rab GTP-Binding Proteins / Q000032:analysis; D020696:rab5 GTP-Binding Proteins / Q000032:analysis; D000090802:rab7 GTP-Binding Proteins
D000090802:rab7 GTP-Binding Proteins; C000716463:rab7 GTP-binding proteins, human; D020691:rab GTP-Binding Proteins; D020696:rab5 GTP-Binding Proteins; D034285:Dynamin II