[Studies on separation, appraisal and the biological activity of 5-HMF in Cornus officinalis].
OBJECTIVE
To develop the mechanism of improving protection function of prepared Cornus officinalis for liver and kidney and the biological activity of 5-hydroxymethylfurfural (5-HMF).


METHODS
Pharmacological and chemical studies were used to choose active part. A compound from active part was separated and appraised. To investigate his biological functions, pharmacological experiment was actualized.


RESULTS
A component was separated and identified. His is 5-HMF. 5-HMF can protect human vein epidermal cell against H2O2 and glucose and inprove acute liver injury in mice.


CONCLUSIONS
5-HMF is the active component in prepared Cornus officinalis and substance basis for protecting liver and kidney.
Department of Chemistry, Nanjing Agricultural University, Nanjing 210095, China. jsnnnxd405@yahoo.com.cn
Xia
X
Ding
Ming-Yan
MY
Wang
Zong-Liang
ZL
Yu
Wei
W
Hu
Bao-Chang
BC
Cai
D000818:Animals; D002478:Cells, Cultured; D029768:Cornus / Q000737:chemistry*; D042783:Endothelial Cells / Q000187:drug effects; D005260:Female; D005662:Furaldehyde / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D011897:Random Allocation
C008046:5-hydroxymethylfurfural; D005662:Furaldehyde