Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1.
The enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of events triggered by stretch begins with the release of small amounts of Angiotensin II (Ang II)/endothelin (ET) and ends with the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger in reverse mode (NCX(rev)), which triggers cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways.
Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, Calle 60 y 120, 1900 La Plata, Argentina. cicmes@infovia.com.ar
Horacio E
HE
Cingolani
Nestor G
NG
Perez
Ernesto A
EA
Aiello
Irene L
IL
Ennis
Carolina D
CD
Garciarena
Maria C
MC
Villa-Abrille
Raul A
RA
Dulce
Claudia I
CI
Caldiz
Alejandra M
AM
Yeves
Maria V
MV
Correa
Mariela B
MB
Nolly
Gladys
G
Chiappe de Cingolani
D000328:Adult; D000804:Angiotensin II / Q000502:physiology; D001696:Biomechanical Phenomena; D006332:Cardiomegaly / Q000235:genetics / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D017380:Hypertrophy, Right Ventricular / Q000503:physiopathology; D009765:Obesity / Q000235:genetics; D011311:Pressoreceptors / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D017923:Sodium-Hydrogen Exchangers / Q000502:physiology*; D016276:Ventricular Function
D017382:Reactive Oxygen Species; D017923:Sodium-Hydrogen Exchangers; C069139:growth factor-activatable Na-H exchanger NHE-1; D000804:Angiotensin II