Fibrinogen induces biofilm formation by Streptococcus suis and enhances its antibiotic resistance.
In this study, we showed that supplementing the culture medium with fibrinogen induced biofilm formation by Streptococcus suis in a dose-dependent manner. Biofilm-grown S. suis cells were much more resistant to penicillin G than planktonic cells. S. suis bound fibrinogen to its surface, a property that likely contributes to biofilm formation.
Bonifait
Laetitia
L
Groupe de Recherche en Ecologie Buccale, Faculté de Médecine Dentaire, Université Laval, Quebec City, Quebec, Canada G1K 7P4.
Grignon
Louis
L
Grenier
Daniel
D
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018441:Biofilms; D024881:Drug Resistance, Bacterial; D005340:Fibrinogen / Q000494:pharmacology*; D006801:Humans; D008322:Mammals; D008855:Microscopy, Electron, Scanning; D017011:Streptococcus suis / Q000145:classification / Q000187:drug effects / Q000254:growth & development* / Q000648:ultrastructure
D000900:Anti-Bacterial Agents; D005340:Fibrinogen