Epithelial-mesenchymal transition and the stem cell phenotype.
Epithelial-mesenchymal transition (EMT) is a developmental process in which epithelial cells acquire the motile, migratory properties of mesenchymal cells. In a recent issue of Cell, Mani et al. (2008) show that induction of EMT stimulates cultured breast cells to adopt characteristics of stem cells.
Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA. radisky.derek@mayo.edu
Derek C
DC
Radisky
Mark A
MA
LaBarge
D000818:Animals; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000473:pathology; D051927:CD24 Antigen / Q000378:metabolism; D002465:Cell Movement; D054338:Cell Transdifferentiation; D002471:Cell Transformation, Neoplastic; D004847:Epithelial Cells / Q000166:cytology*; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D008648:Mesoderm / Q000166:cytology / Q000502:physiology; D009361:Neoplasm Invasiveness; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured
D014408:Biomarkers, Tumor; D051927:CD24 Antigen; D018960:Hyaluronan Receptors