Mild, efficient Friedel-Crafts acylations from carboxylic acids using cyanuric chloride and AlCl3.
A mild method for Friedel-Crafts acylation with aromatic and aliphatic carboxylic acids using cyanuric chloride, pyridine, and AlCl(3) was developed. Both inter- and intramolecular acylations were achieved at room temperature in high yield and in very short reaction times.
Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. cyrouskangani@gmail.com
Cyrous O
CO
Kangani
Billy W
BW
Day
D000215:Acylation; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D015394:Molecular Structure; D013696:Temperature; D014227:Triazines / Q000737:chemistry*
D017607:Aluminum Compounds; D002264:Carboxylic Acids; D002712:Chlorides; D014227:Triazines; D000077410:Aluminum Chloride; C019309:cyanuric chloride