The role of hyperbaric oxygen therapy (hot) as an otoprotection agent against cisplatin ototoxicity.
OBJECTIVE
Hyperbaric oxygen therapy (HOT) consists of intermittent inhalations of 100% oxygen at a pressure higher than 1 atm. It is an important adjuvant therapy in pathological processes like soft tissue infections, radiation injury, gas gangrene, osteomyelitis and decompressive diseases. Cisplatin, a potent antineoplastic drug, widely used in cancer therapy is highly ototoxic causing bilateral, irreversible damage to the hearing of high frequency sounds (4-8 KHz).


OBJECTIVE
This experimental study conducted at the Faculty of Medicine of Ribeirao Preto, University of Sao Paulo aims to evaluate Hyperbaric Oxygen Therapy as an otoprotection agent against drug toxicity.


METHODS
Albino guinea pigs were divided into two groups: in Group A, 5 animals (10 cochlea) received cisplatin, i. p., 8.0 mg/kg/day during three days and afterwards were submitted to HOT; in Group B, 3 animals (6 cochlea) received cisplatin, i. p. 8.0 mg/kg/day during three days. Guinea pigs were evaluated by acoustic otoemissions (AOE) and scanning electron microscopy (SEM).


RESULTS
Group B animals showed loss of auditory functions as measured by AOE and distorted outer hair cells by SEM. In Group A, outer hair cells shown by SEM images were mostly preserved.


CONCLUSIONS
It is presumed that Hyperbaric Oxygen Therapy has a protector effect against cisplatin ototoxicity.
Ribeirao Preto Faculty of Medicine, University of São Paulo, Brazil.
Camila C
CC
Yassuda
Ana Elisa M
AE
Righetti
Maria Cristina L
MC
Cury
Miguel Angelo
MA
Hyppolito
José Antonio A de
JA
Oliveira
Omar
O
Féres
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D019069:Cell Respiration / Q000187:drug effects; D002945:Cisplatin / Q000633:toxicity*; D003051:Cochlea / Q000187:drug effects* / Q000473:pathology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000473:pathology; D034381:Hearing Loss / Q000139:chemically induced / Q000517:prevention & control*; D006931:Hyperbaric Oxygenation; D008928:Mitochondria / Q000187:drug effects / Q000473:pathology; D010101:Oxygen Consumption / Q000187:drug effects
D000970:Antineoplastic Agents; D002945:Cisplatin