Delay in diagnosis in poststreptococcal glomerulonephritis.
OBJECTIVE
To determine the frequency and risk factors for diagnostic delays in children with poststreptococcal glomerulonephritis (PSGN).


METHODS
We reviewed the charts of 52 children with PSGN, and identified children with a delay in diagnosis of more than 24 hours. We determined risk factors for delay in diagnosis using univariate and multivariate logistic regression.


RESULTS
17 children (33%) with PSGN had a delay in diagnosis. Delay in diagnosis occurred in 14% of children with gross hematuria as a presenting complaint and in 54% of children without gross hematuria as a presenting complaint (3.8 increased relative risk, 95% CI = 1.4 to 10; P = .02). A delay in diagnosis was more common in children with a negative infection history (P = .04). In multiple logistic regression, only the absence of gross hematuria as a presenting complaint was associated with a delay in diagnosis (P = .01). All children with a delay in diagnosis had microscopic hematuria on their initial urinalysis.


CONCLUSIONS
Delay in diagnosis is common in children with PSGN, especially if visible hematuria is not a presenting complaint. Physicians should consider the possibility of PSGN in children with symptoms that may be secondary to volume overload. A urinalysis is a helpful initial diagnostic test.
Pais
Priya J
PJ
Department of Pediatrics, Medical College of Wisconsin and Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA.
Kump
Theresa
T
Greenbaum
Larry A
LA
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D016015:Logistic Models; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D013290:Streptococcal Infections / Q000150:complications*; D013997:Time Factors