Viral diversity and dynamics in an infant gut.
Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.
College of Marine Sciences, University of South Florida, 140 Seventh Avenue South, Saint Petersburg, FL 33701, USA. mya@marine.usf.edu
Mya
M
Breitbart
Matthew
M
Haynes
Scott
S
Kelley
Florent
F
Angly
Robert A
RA
Edwards
Ben
B
Felts
Joseph M
JM
Mahaffy
Jennifer
J
Mueller
James
J
Nulton
Steve
S
Rayhawk
Beltran
B
Rodriguez-Brito
Peter
P
Salamon
Forest
F
Rohwer
D044822:Biodiversity; D004267:DNA Viruses / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification* / Q000648:ultrastructure; D004279:DNA, Viral / Q000235:genetics; D005243:Feces / Q000821:virology; D041981:Gastrointestinal Tract / Q000821:virology*; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000032:analysis; D008297:Male; D008969:Molecular Sequence Data; D020411:Oligonucleotide Array Sequence Analysis
D004279:DNA, Viral