A common polymorphism is associated with body mass index in Uyghur population.
We aimed at observing the association of a common genetic variant near the INSIG2 gene (rs7655505) with body mass index (BMI) related obesity in a population-based association study in Uyghur population. We observed a significant association of rs7566605 polymorphism with BMI related obesity in Uyghurs with an odds ratio of 1.47 (95% CI 1.11-1.95, P=0.006) under a dominant model (CC+GC versus GG). The mean BMI of rs7566605 CC+GC was 0.59kg/m(2) higher than for GG genotype (P=0.024), regardless of sex and age.
MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Jun
J
Zhang
Rong
R
Lin
Fen
F
Wang
Ming
M
Lu
Ren-yong
RY
Lin
Shi-zhen
SZ
Wang
Hao
H
Wen
Li
L
Jin
Xiao-feng
XF
Wang
D015992:Body Mass Index; D002681:China; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D009765:Obesity / Q000235:genetics; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012044:Regression Analysis
C467727:INSIG2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins