Terminal deoxynucleotidyl transferase negative T-cell lymphoblastic lymphoma in aleukemic patient.
Precursor lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL) is a malignant neoplasm of precursor lymphocytes of T- or B-cell phenotype. We describe the unusual features of an ALL/LBL in an adolescent man in whom the disease presented with involvement of lymph nodes, but without bone marrow and peripheral blood involvement. Immunohistochemical studies revealed that the tumor cells were positive for CD3, CD34 class II, CD10, CD79a and CD99 but negative for TdT. Even though TdT was negative, he received ALL-therapy and is now in remission.
Department of Pathology, Zagreb University Hospital Center, Kišpatićeva 12, 10000, Zagreb, Croatia.
Iva
I
Brčić
Department of Internal Medicine, Zagreb University Hospital Center, Zagreb, Croatia.
Boris
B
Labar
Department of Pathology, Zagreb University Hospital Center, Kišpatićeva 12, 10000, Zagreb, Croatia.
Melita
M
Perić-Balja
Department of Internal Medicine, Zagreb University Hospital Center, Zagreb, Croatia.
Sandra
S
Bašić-Kinda
Department of Pathology, Zagreb University Hospital Center, Kišpatićeva 12, 10000, Zagreb, Croatia. marin.nola@zg.t-com.hr.
Marin
M
Nola
D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001706:Biopsy; D001854:Bone Marrow Cells / Q000166:cytology; D004253:DNA Nucleotidylexotransferase / Q000378:metabolism*; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology*; D008206:Lymphatic Diseases / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000473:pathology*; D012074:Remission Induction
D014408:Biomarkers, Tumor; D004253:DNA Nucleotidylexotransferase