Cerebral meningioangiomatosis in a CD-1 mouse: a case report and comparison with humans and dogs.
Meningioangiomatosis is a rare proliferative disorder of the central nervous system. Several cases have been described in humans, a few in dogs, one case in a cow and one in a horse; meningioangiomatosis has never been recorded in rodents. The pathogenesis of this condition remains obscure and it is uncertain whether it represents a neoplastic or malformative process. Meningioangiomatosis is usually characterized by a plaque-like leptomeningeal proliferation of mainly spindle-shaped cells and small blood vessels, extending along the Virchow-Robin spaces into the adjacent neural parenchyma. In this report, we presented a brain lesion displaying the histopathological key features of the meningioangiomatosis and involving the base of the cerebrum (fronto-basal area) and the brainstem, found in a male CD-1 mouse. The histopathological and immunohistochemical results are discussed, and compared with those previously reported in other cases of meningioangiomatosis.
Department of pathology, Veterinary school of Alfort, 94704 Maisons-Alfort, France.
Emmanuelle
E
Balme
Daniel Robert
DR
Roth
Elias
E
Perentes
D000798:Angiomatosis / Q000378:metabolism / Q000473:pathology* / Q000662:veterinary*; D000818:Animals; D001927:Brain Diseases / Q000378:metabolism / Q000473:pathology* / Q000662:veterinary*; D004285:Dogs; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008578:Meninges / Q000473:pathology; D051379:Mice