Use of topical dorzolamide for patients with X-linked juvenile retinoschisis: case report.
X-linked juvenile retinoschisis (XLRS) is a recessively inherited vitreoretinal degeneration characterized by macular pathology and splitting of the neuroretinal layers that is associated with alterations in the XLRS1 gene. There have been no therapeutic interventions known to be effective for patients with X-linked juvenile retinoschisis, but some studies are trying to determine the importance of dorzolamide for the treatment of foveal lesions in this disease. The authors, using optical coherence tomography, describe findings in a patient with X-linked juvenile retinoschisis, before and after a topical use of dorzolamide. Besides the improvement in his visual acuity, further studies are required to elucidate the real prevalence of nonresponse to dorzolamide and the frequency with which there may be a recurrence of foveal cystic changes during continued treatment.
Departamento de Retina e Vítreo, Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira, Salvador, BA, Brasil.
André Luís Carvalho de Moura
AL
Bastos
Bruno de Paula
Bde P
Freitas
Oscar
O
Villas Boas
Alexandre Campelo
AC
Ramiro
D000287:Administration, Topical; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D002648:Child; D006801:Humans; D008297:Male; D011859:Radiography; D041441:Retinoschisis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D013449:Sulfonamides / Q000008:administration & dosage*; D013876:Thiophenes / Q000008:administration & dosage*; D013997:Time Factors
D000959:Antihypertensive Agents; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide