Pulmonary nocardiosis with brain abscess in a sensitized kidney transplant recipient with a history of repeated graft loss and HLA-antibody depletion treatment--a case report.
Nocardiosis is an opportunistic infection with unfavourable prognosis and is predominantly seen in immunocompromised patients. We here present a kidney transplant recipient with a history of two early graft losses who subsequently developed Human Leukocyte Antigen (HLA)-antibodies and underwent a desensitization treatment with plasmapheresis and monoclonal anti-CD20 antibody application. However, 3 months after a third HLA-identical kidney transplantation he developed Nocardiosis with pulmonary and asymptomatic brain manifestation. The present case report exemplifies this opportunistic infection and gives an overview of the literature.
Department of Surgical Sciences, Section of Transplantation Surgery, Uppsala University Hospital, Uppsala, Sweden. alireza.biglarnia@akademiska.se
Ali-Reza
AR
Biglarnia
Jonas
J
Wadström
Gunnar
G
Tufveson
Britt-Marie
BM
Eriksson
D001323:Autoantibodies / Q000276:immunology / Q000302:isolation & purification*; D001922:Brain Abscess / Q000150:complications / Q000628:therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage; D016572:Cyclosporine / Q000008:administration & dosage; D006084:Graft Rejection; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016030:Kidney Transplantation; D008171:Lung Diseases / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009617:Nocardia Infections / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome
D001323:Autoantibodies; D006680:HLA Antigens; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003520:Cyclophosphamide