Carriage of Candida species in oral cavities of HIV infected patients in South India.
Fifty-four patients with human immunodeficiency virus (HIV) infection were studied to assess the load of oral carriage of Candida spp. The mean oral Candida carriage density (30,305.93 +/- 56,643.93 CFU ml(-1)) in HIV patients was significantly higher than that seen in the control population (93.48 +/- 358.48 CFU ml(-1); P = 0.000). The mean Candida load in HIV patients with oral thrush (46,591.43 +/- 65,002.57 CFU ml(-1)) was significantly higher than in the HIV subjects without oral thrush (306.32 +/- 699.50 CFU ml(-1); P = 0.000). Non-C. albicans Candida species (56%) were more predominant than the C. albicans (44%) isolates. 25S rDNA PCR analysis of C. albicans revealed preponderance of genotype A strains. Interestingly, 42.6% of rinse specimens grew multiple Candida species, with the combination of C. albicans and C. krusei (39.1%) being the most frequent.
Department of Microbiology, Dr A. L. Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, Tamil Nadu, India.
C P
CP
Girish Kumar
Thangam
T
Menon
S
S
Rajasekaran
B
B
Sekar
D
D
Prabu
D000328:Adult; D002175:Candida / Q000145:classification / Q000302:isolation & purification*; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology*; D015169:Colony Count, Microbial; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D009055:Mouth / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D012331:RNA, Fungal / Q000235:genetics; D012335:RNA, Ribosomal / Q000235:genetics
D012331:RNA, Fungal; D012335:RNA, Ribosomal; C065039:RNA, ribosomal, 25S