Alpha-glucosidase inhibitor from Chinese aloes.
Activity-guided fractionation of the methanol extract of Chinese aloes led to the isolation of aloeresin A, which demonstrated significant dose dependent alpha-glucosidase inhibitory activities, with IC(50) values of 11.94 and 2.16 mM, against rat intestinal sucrase and maltase, respectively.
Jong-Anurakkun
Nilubon
N
Laboratory of Food Biochemistry, Division of Applied Bioscience,Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan. j_nilubon@hotmail.com
Bhandari
Megh Raj
MR
Hong
Gao
G
Kawabata
Jun
J
D000504:Aloe / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003920:Diabetes Mellitus / Q000188:drug therapy; D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D008517:Phytotherapy; D018515:Plant Leaves; D051381:Rats
D001786:Blood Glucose; D002867:Chromones; D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors; D005960:Glucosides; D065089:Glycoside Hydrolase Inhibitors; C521199:aloeresin A