Modulation of the inflammatory response for enhanced bone tissue regeneration.
Proinflammatory cytokines are infamous for their catabolic effects on tissues and joints in both inflammatory diseases and following the implantation of biomedical devices. However, recent studies indicate that many of these same molecules are critical for triggering tissue regeneration following injury. This review will discuss the role of inflammatory signals in regulating bone regeneration and the impact of both immunomodulatory and antiinflammatory pharmacologic agents on fracture healing, to demonstrate the importance of incorporating rational control of inflammation into the design of tissue engineering strategies.
Department of Bioengineering, Rice University, Houston, Texas 77251-1892, USA.
Paschalia M
PM
Mountziaris
Antonios G
AG
Mikos
D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D001861:Bone Regeneration / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D050723:Fractures, Bone / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use; D018836:Inflammation Mediators / Q000502:physiology; D010000:Osteitis / Q000517:prevention & control*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D023822:Tissue Engineering / Q000379:methods; D014945:Wound Healing / Q000187:drug effects / Q000276:immunology / Q000502:physiology
D000893:Anti-Inflammatory Agents; D007155:Immunologic Factors; D018836:Inflammation Mediators