Paraneoplastic cerebellar degeneration with anti-Yo antibody in a patient with HER2/neu overexpressing breast cancer: a case report with a current literature review.
Paraneoplastic cerebellar degeneration (PCD) is a rare paraneoplastic syndrome, occurring in <1% of breast cancers. We describe a 32-year-old female presenting with ataxia subsequently diagnosed with poorly differentiated breast cancer. She was serum anti-Yo antibody positive, with estrogen/progesterone receptor negative and HER2/neu receptor positive breast cancer. Neurological symptoms progressed despite modified radical mastectomy, supraclavicular lymphadenectomy, intravenous immunoglobulin, corticosteroids, transtuzumab, and combination chemotherapy. We performed a literature search, which found a possible association between anti-Yo positive PCD and HER2/neu-expressing breast cancer.
Ogita
Shin
S
Department of Medicine, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, New York, USA.
Llaguna
Omar H
OH
Feldman
Sheldon M
SM
Blum
Ronald
R
D001323:Autoantibodies / Q000097:blood*; D001943:Breast Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D009419:Nerve Tissue Proteins; D020362:Paraneoplastic Cerebellar Degeneration / Q000276:immunology*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*
D001323:Autoantibodies; D009419:Nerve Tissue Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; C095184:CDR2 protein, human