Diagnostic value of combining bilateral electrocochleography results for unilateral Ménière's disease.
We defined 'an interaural difference in the summating potential/action potential (SP/AP) ratio from the ipsilateral hearing-impaired side to the contralateral normal-hearing side of > or =0.15' as a positive result for a novel 'relative criterion' for the diagnosis of unilateral Ménière's disease. A uniform result could be derived only between a positive ECoG result and the side of disease in 78.7% subjects by conventional absolute criterion (SP/AP > or =0.42). By adding the relative criterion, we found that the diagnostic value increased greatly in specificity (91.2%) and increased slightly in positive predictive rate (79.2%), but decreased greatly in sensitivity (28.8%) and decreased slightly in negative predictive rate (52.5%). In addition, we verified which ear had the disease in all positive cases.
Hwang
J H
JH
School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
Ho
H C
HC
Hsu
C J
CJ
Yang
W S
WS
Liu
T C
TC
D000200:Action Potentials; D000328:Adult; D001300:Audiometry, Evoked Response / Q000379:methods*; D001309:Auditory Threshold; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis* / Q000503:physiopathology*; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014432:Tympanic Membrane