Midbrain acetylcholine and glutamate receptors modulate accumbal dopamine release.
This study determined the role of ventral tegmental area acetylcholine and glutamate receptors in modulating laterodorsal tegmentum stimulation-evoked dopamine efflux in the nucleus accumbens. Rapid changes in dopamine oxidation current were measured at carbon fiber microelectrodes using fixed potential amperometry in urethane anesthetized male mice. Intraventral tegmental area infusions of the muscarinic acetylcholine receptor antagonist scopolamine, the nicotinic acetylcholine receptor antagonist mecamylamine, or the ionotropic glutamate receptor antagonist kynurenate significantly diminished dopamine efflux in the nucleus accumbens evoked by brief electrical stimulation of the laterodorsal tegmentum. These findings suggest that acetylcholine and ionotropic glutamate receptors influence rapid dopaminergic activity and thus the communication of behaviorally relevant information from ventral tegmental area dopamine cells to forebrain areas.
Department of Psychology, University of Memphis, Memphis, Tennessee 38152-6400, USA.
Deranda B
DB
Lester
Anthony D
AD
Miller
Tiffany D
TD
Pate
Charles D
CD
Blaha
D000818:Animals; D018680:Cholinergic Antagonists / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation / Q000379:methods; D004563:Electrochemistry / Q000379:methods; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D007736:Kynurenic Acid / Q000494:pharmacology; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D008636:Mesencephalon / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009714:Nucleus Accumbens / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000502:physiology*; D017470:Receptors, Glutamate / Q000502:physiology*; D012601:Scopolamine / Q000494:pharmacology; D017557:Ventral Tegmental Area / Q000187:drug effects / Q000502:physiology*
D018680:Cholinergic Antagonists; D018691:Excitatory Amino Acid Antagonists; D011950:Receptors, Cholinergic; D017470:Receptors, Glutamate; D008464:Mecamylamine; D012601:Scopolamine; D007736:Kynurenic Acid; D004298:Dopamine