Aspirin decreases the prevalence and severity of heterotopic ossification after 1-stage bilateral total hip arthroplasty for osteoarthrosis.
Heterotopic ossification (HO) is a frequent complication after total hip arthroplasty (THA). We retrospectively evaluated the prevalence and severity of HO in patients with osteoarthrosis who underwent 1-stage bilateral THA (OSBTHA) and compared those who received aspirin with those who received Coumadin for postoperative chemothromboprophylaxis. The aspirin group consisted of 66 patients (132 hips), with a mean age of 64 years (SD, 8.5). The Coumadin group consisted of 67 patients (134 hips), with a mean age of 60 years (SD, 10.2). Overall, HO was detected in 124 hips (46.6%). There were 43 hips (32.5%) with HO in the aspirin group and 81 (60.4%) in the Coumadin group (P < .00005). Aspirin significantly decreases the prevalence and severity of HO in comparison to Coumadin after OSBTHA.
Bek
Doğan
D
Department of Orthopaedic Surgery, Hip and Knee Service, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York 10021, USA.
Beksaç
Burak
B
Della Valle
Alejandro González
AG
Sculco
Thomas P
TP
Salvati
Eduardo A
EA
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000925:Anticoagulants / Q000627:therapeutic use; D019644:Arthroplasty, Replacement, Hip; D001241:Aspirin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000188:drug therapy* / Q000517:prevention & control*; D015207:Osteoarthritis, Hip / Q000601:surgery*; D015995:Prevalence; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013927:Thrombosis / Q000517:prevention & control; D014859:Warfarin / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D014859:Warfarin; D001241:Aspirin