Antifouling activity of meroditerpenoids from the marine brown alga Halidrys siliquosa.
Nine tetraprenyltoluquinol-related metabolites (1-9) have been isolated from the organic extract of the temperate brown alga Halidrys siliquosa that exhibits antifouling properties. The planar structure of compounds 1-9 was elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of related metabolites. Antifouling and toxicity tests were conducted on these compounds: the most active (compounds 2, 6, and 9) inhibited both the growth of four strains of bacteria (MICs < 2.5 microg/mL) and settlement of cyprids of Balanus amphitrite (EC50 < 5 microg/mL), the latter at nontoxic concentrations (LC50 > 5 microg/mL).
Laboratoire des Matériaux à Finalités Spécifiques, Université du Sud Toulon-Var, Avenue de l'Université, BP 20132, F-83957 La Garde Cedex, France. culioli@univ-tln.fr
Gérald
G
Culioli
Annick
A
Ortalo-Magné
Robert
R
Valls
Claire
C
Hellio
Anthony S
AS
Clare
Louis
L
Piovetti
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005602:France; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000459:Phaeophyceae / Q000737:chemistry*; D001468:Thoracica / Q000187:drug effects* / Q000254:growth & development
D000900:Anti-Bacterial Agents; D004224:Diterpenes