[Composite lymphoma: association of a follicular lymphoma and a chronic lymphocytic leukemia].
We report the case of a 71-year-old woman presenting with composite lymphoma (CL) composed of a follicular lymphoma and a B-cell chronic lymphocytic leukemia. CL is a rare lymphoproliferative disorder, characterized by two distinct morphological and immunophenotypical patterns in the same anatomical site, most frequently of biclonal origin. This entity must be distinguished from transformation of low-grade lymphoma into high-grade lymphoma and from lymphoma with differentiation such as follicular lymphoma with marginal differentiation. In this context, molecular analysis including immunoglobulin rearrangement, sequencing and FISH analyses is determinant and can be improved by tissue microdissection. Routinely, CL must not be misdiagnosed because of its prognosis and treatment implication.
Service d'anatomie et cytopathologie, département de pathologie et biologie moléculaire, hôpital du Haut-Lévêque, CHU de Bordeaux, avenue de Magellan, 33604 Pessac, France.
Florian
F
Rabiller
Marc-Antoine
MA
Belaud-Rotureau
Olivier
O
Fitoussi
Pierre
P
Dubus
Jean-Philippe
JP
Merlio
Antoine
A
de Mascarel
Marie
M
Parrens
D000368:Aged; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000473:pathology*; D008224:Lymphoma, Follicular / Q000150:complications* / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis
D019253:Proto-Oncogene Proteins c-bcl-2