[Association of metabolic syndrome and oxidative stress with ischemic heart disease in middle-aged persons].
The aim of this study was to evaluate the association of metabolic syndrome and oxidative stress with ischemic heart disease in middle-aged persons (men and women aged 45-64 years).


METHODS
In this study, we have used data of 533 persons (247 men and 286 women) aged 45-64 years from Kaunas population cohort investigated according to WHO MONICA study protocol during 2001-2002 in whom concentrations of malondialdehyde, a marker of lipid peroxidation, and antioxidant vitamin E in blood serum were determined. Metabolic syndrome was defined by the criteria of Adult Treatment Panel III. Oxidative stress was determined in the presence of increased level of malondialdehyde (> or =5 micromol/L) and decreased level of lipid-standardized vitamin E (<20 micromol/L). The levels of malondialdehyde and vitamin E were measured by fluorimetric methods.


RESULTS
Ischemic heart disease was diagnosed in 19.8% of men and 21.3% of women. The frequency of ischemic heart disease among persons (men and women) with metabolic syndrome was significantly higher than among persons without metabolic syndrome (27.4% vs. 17.8%, respectively; odds ratio, 1.63; P=0.032). The frequency of ischemic heart disease among persons with oxidative stress was significantly higher than among persons without oxidative stress (29.1% vs. 17.6%, respectively; odds ratio, 1.88; P=0.029). The highest prevalence of ischemic heart disease (30.0%) was among persons with metabolic syndrome and oxidative stress, and the lowest prevalence of this disease (13.8%) was among persons without metabolic syndrome and without oxidative stress (odds ratio, 2.54; P=0.017). These data were adjusted by sex and age.


CONCLUSIONS
Metabolic syndrome and oxidative stress are significantly associated with ischemic heart disease among 45-64-year-old persons.
Institute of Cardiology, Kaunas University of Medicine, Lithuania. klbioch@kmu.lt
Liucija Rita
LR
Cerniauskiene
Dalia Ieva
DI
Luksiene
Abdonas
A
Tamosiūnas
Regina
R
Reklaitiene
Lilija
L
Margeviciene
D000367:Age Factors; D015331:Cohort Studies; D005260:Female; D005470:Fluorometry; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D024821:Metabolic Syndrome / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D018384:Oxidative Stress; D015995:Prevalence; D012737:Sex Factors; D014810:Vitamin E / Q000097:blood
D014810:Vitamin E; D008315:Malondialdehyde