Association study between the PIK4CA gene and methamphetamine use disorder in a Japanese population.
Accumulating evidence suggests that phosphatidylinositol (PI) pathways have been involved in the secretion of dopamine (DA) and the regulation of DA transporter, which is a target of methamphetamine (METH). A recent large-scale gene-association study in a Dutch population demonstrated that the PIK4CA gene was closely linked to schizophrenia [Jungerius et al. (2007); Mol Psychiatry]. Here, we conducted a case (N = 232)-control (N = 233) study of the PIK4CA gene on Japanese METH abusers, which can manifest severe psychosis similar to schizophrenia. The genotype and allelic distributions of all four single nucleotide polymorphisms (SNPs) did not differ significantly between the METH abusers and the controls. The comparisons based on the classification of the psychosis as transient or prolonged and on the presence or absence of spontaneous relapse revealed no significant distribution of the four SNPs compared to the controls. Furthermore, haplotype analyses showed almost the same frequencies between the METH abusers and the controls. The present study suggests that the PIK4CA gene does not play a significant role in the vulnerability to METH use disorder in the Japanese population.
Department of Psychiatry, Chiba University Graduate School of Medicine, Japan.
Nobuhisa
N
Kanahara
Ryosuke
R
Miyatake
Yoshimoto
Y
Sekine
Toshiya
T
Inada
Norio
N
Ozaki
Nakao
N
Iwata
Mutsuo
M
Harano
Tokutaro
T
Komiyama
Mitsuhiko
M
Yamada
Ichiro
I
Sora
Hiroshi
H
Ujike
Masaomi
M
Iyo
Kenji
K
Hashimoto
D000328:Adult; D000368:Aged; D000483:Alleles; D019969:Amphetamine-Related Disorders / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D015778:Minor Histocompatibility Antigens; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics*; D011618:Psychotic Disorders / Q000235:genetics*
D015778:Minor Histocompatibility Antigens; D008694:Methamphetamine; D017853:Phosphotransferases (Alcohol Group Acceptor); C402182:phosphatidylinositol phosphate 4-kinase