Characterization of extended-spectrum beta-lactamases in Salmonella spp. at a tertiary hospital in Durban, South Africa.
Extended-spectrum beta-lactamases (ESBLs) were characterized in 41 Salmonella spp. isolates from patients admitted to a pediatric ward of a tertiary hospital in Durban, South Africa. The most common (17/ 41) serotype was Salmonella enterica serotype Typhimurium, followed by S. enterica serotype Isangi (16/41), S. enterica serotype Saint-paul (2/41), S. enterica serotype Kissi (2/41), S. enterica serotype Kivu (2/41), and S. enterica serotype Reading (1/41). All isolates were resistant to ampicillin, amoxicillin-clavulanate, piperacillin, ceftazidime, and aztreonam but susceptible to meropenem. SHV-12 found in 39% of the isolates was the most common ESBL. TEM-63 was produced in 29% and TEM-116 in 10% of the isolates, and TEM-131 was found in 1 isolate. Other ESBLs that were identified included SHV-2 (n = 2), CTX-M-3 (n = 1), CTX-M-15 (n = 2), and CTX-M-37 (n = 5). In addition, CMY-2 (n = 3) and the OXA-1(n = 1) beta-lactamase were also detected. The diversity of ESBLs suggests that its incidence in Salmonellae needs to be monitored.
Usha
Govinden
G
School of Pharmacy and Pharmacology, University of Kwazulu Natal, Durban, Kwazulu Natal 4000, South Africa. govindenu@ukzn.ac.za
Chunderika
Mocktar
M
Prashini
Moodley
M
Willem
Sturm Adriaan
SA
Yusuf
Essack Sabiha
ES
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003967:Diarrhea / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D006761:Hospitals; D006801:Humans; D007231:Infant, Newborn; D007525:Isoelectric Focusing; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D012475:Salmonella / Q000145:classification / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D012480:Salmonella Infections / Q000453:epidemiology / Q000382:microbiology; D017422:Sequence Analysis, DNA; D013019:South Africa / Q000453:epidemiology; D001618:beta-Lactamases / Q000145:classification* / Q000235:genetics
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases