Impact of burkholderia infection on lung transplantation in cystic fibrosis.
BACKGROUND
Lung transplantation offers the only survival option for patients with cystic fibrosis (CF) with end-stage pulmonary disease. Infection with Burkholderia species is typically considered a contraindication to transplantation in CF. However, the risks posed by different Burkholderia species on transplantation outcomes are poorly defined.


OBJECTIVE
To quantify the risks of infection with Burkholderia species on survival before and after lung transplantation in patients with CF.


METHODS
Multivariate Cox survival models assessed hazard ratios of infection with Burkholderia species in 1,026 lung transplant candidates and 528 lung transplant recipients. Lung allocation scores, incorporating Burkholderia infection status, were calculated for transplant candidates.


RESULTS
Transplant candidates infected with different Burkholderia species did not have statistically different mortality rates. Among transplant recipients infected with B. cenocepacia, only those infected with nonepidemic strains had significantly greater post-transplant mortality compared with uninfected patients (hazard ratio [HR], 2.52; 95% confidence interval [CI], 1.04-6.12; P = 0.04). Hazards were similar between uninfected transplant recipients and those infected with B. multivorans (HR, 0.66; 95% CI, 0.27-1.56; P = 0.34). Transplant recipients infected with B. gladioli had significantly greater post-transplant mortality than uninfected patients (HR, 2.23; 95% CI, 1.05-4.74; P = 0.04). Once hazards for species/strain were included, lung allocation scores of B. multivorans-infected transplant candidates were comparable to uninfected candidate scores, whereas those of candidates infected with nonepidemic B. cenocepacia or B. gladioli were lower.


CONCLUSIONS
Post-transplant mortality among patients with CF infected with Burkholderia varies by infecting species. This variability should be taken into account in evaluating lung transplantation candidates.
Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA.
Susan
S
Murray
Jeffery
J
Charbeneau
Bruce C
BC
Marshall
John J
JJ
LiPuma
D000328:Adult; D019121:Burkholderia Infections / Q000401:mortality / Q000601:surgery*; D016022:Case-Control Studies; D015331:Cohort Studies; D000075202:Contraindications; D003550:Cystic Fibrosis / Q000401:mortality / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D015999:Multivariate Analysis; D018410:Pneumonia, Bacterial / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications / Q000401:mortality*; D011379:Prognosis; D012306:Risk; D015996:Survival Rate; D016896:Treatment Outcome; D014481:United States