GABAergic signalling to adult-generated neurons.
New neurons are continuously generated in discrete regions of the adult brain. In the hippocampus, newly generated cells undergo a step-wise progression of maturation that is regulated at multiple stages by a variety of physiological and pathological stimuli. Neural progenitors and newborn neurons initially receive exclusively GABAergic synaptic input, and accumulating evidence suggests that depolarizing actions of GABA contribute to activity-dependent regulation. Here we provide a brief overview of GABAergic signalling to newborn neurons in the hippocampus and describe how it regulates adult neurogenesis.
Markwardt
Sean
S
Department of Neurobiology and Evelyn McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Overstreet-Wadiche
Linda
L
D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology* / Q000502:physiology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D009474:Neurons / Q000166:cytology* / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D018079:Receptors, GABA / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D018377:Neurotransmitter Agents; D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid