[Clinical and EEG studies of symptomatic focal epilepsy in 7 patients with colpocephaly].
The clinical observations of seven patients with epileptic seizures and colpocephaly were summarized. The ages at the time of onset of the seizures were usually under 1 year, and the frequency of seizures in the late-onset cases was lower than that in the early-onset cases. The seizures were characterized by vomiting, eye deviation, versive seizures, and focal motor seizures. Interictal electroencephalograms showed either unilateral or synchronous bilateral spikes (and wave) or slowing of the basic activity in the occipital area. The basic activity slowed down in all of the cases. Epileptic seizures accompanied with colpocephaly may derive from epileptic foci in the occipital and posterior temporal region, which is structurally abnormal. Ongoing convulsions ceased after the intravenous administration of diazepam. In addition, the oral antiepileptics clobazam and clorazepate proved to be effective for the treatment of refractory cases.
Department of Pediatrics, School of Medicine, Tokyo Women's Medical University, Tokyo. y_itoh@ped.twmu.ac.jp
Yasushi
Y
Ito
Hirokazu
H
Oguni
Makoto
M
Funatsuka
Makiko
M
Osawa
D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage; D001569:Benzodiazepines / Q000008:administration & dosage; D002552:Cerebral Ventricles / Q000002:abnormalities* / Q000473:pathology; D002648:Child; D003975:Diazepam / Q000008:administration & dosage; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male
D000927:Anticonvulsants; D001569:Benzodiazepines; D003975:Diazepam