Effects of neonatal repeated MK-801 treatment on delayed nonmatching-to-position responses in rats.
This study was carried out to investigate the long-term effects of chronic neonatal antagonism of N-methyl-D-aspartate (NMDA) receptors, a subtype of glutamate receptors, on working memory. Rats were tested on the delayed nonmatching-to-position task in adulthood after repeated treatment of a noncompetitive NMDA antagonist MK-801 in postnatal days 7-20. As a result, this treatment led to deficits in learning and/or performance of delayed nonmatching-to-position responses, suggesting that chronic neonatal NMDA antagonism persistently impairs working memory. Furthermore, it decreased body and brain weight, and induced stereotyped head-rotation behavior. As working memory deficits are shown in several mental disorders such as schizophrenia and developmental disorders, rats with chronic neonatal NMDA antagonism might be useful for a better understanding of these disorders.
Graduate School of Literature and Human Sciences, Osaka City University, Sugimoto, Sumiyoshi-ku, Osaka, Japan. kawabe@lit.osaka-cu.ac.jp
Kouichi
K
Kawabe
Eri
E
Miyamoto
D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005260:Female; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects*; D013037:Spatial Behavior / Q000187:drug effects*
D018691:Excitatory Amino Acid Antagonists; D016291:Dizocilpine Maleate