Convergent synthesis of (2R,3R,8R,9R)-N-Boc-ADDA.
The convergent synthesis of N-Boc-(2R,3R,8R,9R,4E,6E)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldecadenoic acid (enantio-N-Boc-ADDA) is reported. Our flexible approach takes advantage of highly efficient non-aldol aldol and cross-metathesis methodologies.
Meiries
Sebastien
S
WestCHEM, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ, UK.
Marquez
Rodolfo
R
D000475:Alkenes / Q000138:chemical synthesis*; D003652:Decanoic Acids / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors
D000475:Alkenes; D003652:Decanoic Acids; C531442:N-Boc-(2R,3R,8R,9R,4E,6E)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldecadenoic acid; D010749:Phosphoprotein Phosphatases