GABAergic signalling to adult-generated neurons.
New neurons are continuously generated in discrete regions of the adult brain. In the hippocampus, newly generated cells undergo a step-wise progression of maturation that is regulated at multiple stages by a variety of physiological and pathological stimuli. Neural progenitors and newborn neurons initially receive exclusively GABAergic synaptic input, and accumulating evidence suggests that depolarizing actions of GABA contribute to activity-dependent regulation. Here we provide a brief overview of GABAergic signalling to newborn neurons in the hippocampus and describe how it regulates adult neurogenesis.
Department of Neurobiology and Evelyn McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Sean
S
Markwardt
Linda
L
Overstreet-Wadiche
D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology* / Q000502:physiology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D009474:Neurons / Q000166:cytology* / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D018079:Receptors, GABA / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D018377:Neurotransmitter Agents; D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid