Imported PER-1 producing Pseudomonas aeruginosa, PER-1 producing Acinetobacter baumanii and VIM-2-producing Pseudomonas aeruginosa strains in Hungary.
BACKGROUND
Pseudomonas aeruginosa and Acinetobacter baumanii are important nosocomial pathogens with wide intrinsic resistance. However, due to the dissemination of the acquired resistance mechanisms, such as extended-spectrum beta-lactamase (ESBL) and metallo beta-lactamase (MBL) production, multidrug resistant strains have been isolated more often.


METHODS
We report a case of a Hungarian tourist, who was initially hospitalized in Egypt and later transferred to Hungary. On the day of admission PER-1-producing P. aeruginosa, PER-1 producing A. baumannii, SHV-5-producing Klebsiella pneumoniae and VIM-2-producing P. aeruginosa isolates were subcultured from the patient's samples in Hungary. Comparing the pulsed-field gel electrophoresis (PFGE) patterns of the P. aeruginosa strains from the patient to the P. aeruginosa strains occurring in this hospital, we can state that the PER-1-producing P. aeruginosa and VIM-2-producing P. aeruginosa had external origin.


CONCLUSIONS
This is the first report of PER-1-producing P. aeruginosa,and PER-1-producing A. baumanii strains in Hungary. This case highlights the importance of spreading of the beta-lactamase-mediated resistance mechanisms between countries and continents, showing the importance of careful screening and the isolation of patients arriving from a different country.
Szabó
Dora
D
Institute of Medical Microbiology, Semmelweis University, Budapest, H-1089, Nagyvárad tér 4., Hungary. szabdor@net.sote.hu
Szentandrássy
Julia
J
Juhász
Zsuzsa
Z
Katona
Katalin
K
Nagy
Károly
K
Rókusz
László
L
D000151:Acinetobacter Infections / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000201:enzymology* / Q000302:isolation & purification; D015373:Bacterial Typing Techniques; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D004534:Egypt; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D006814:Hungary; D007711:Klebsiella pneumoniae / Q000201:enzymology / Q000302:isolation & purification; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D014195:Travel; D001618:beta-Lactamases / Q000096:biosynthesis*
D004269:DNA, Bacterial; C108863:beta-lactamase PER-1; C425108:beta-lactamase bla(vim-2); D001618:beta-Lactamases