Seven-Tesla magnetic resonance imaging: new vision of microvascular abnormalities in multiple sclerosis.
BACKGROUND
Although the role of vascular pathology in multiple sclerosis (MS) lesions was suggested long ago, the derivation of these lesions from the vasculature has been difficult to assess in vivo. Ultrahigh-field (eg, 7-T) magnetic resonance imaging (MRI) has become a tool for assessing vascular involvement in MS lesions owing to markedly increased image resolution and susceptibility contrast of venous blood.


OBJECTIVE
To describe the perivenous association of MS lesions on high-resolution and high-contrast 7-T susceptibility-sensitive MRI.


METHODS
Case study.


METHODS
University hospital.


METHODS
Two women with clinically definite relapsing-remitting MS.


RESULTS
We demonstrated markedly enhanced detection of unique microvascular involvement associated with most of the visualized MS lesions with abnormal signals on and around the venous wall on 7-T compared with 3-T MRI.


CONCLUSIONS
These findings, which have never been shown on conventional fields of MRI, not only allow for direct evidence of vascular pathogenesis in MS in vivo but also have important implications for monitoring lesion activity and therapeutic response.
Ge
Yulin
Y
Department of Radiology, Center for Biomedical Imaging, New York University School of Medicine, 650 First Ave, Room 615, New York, NY 10016, USA. yulin.ge@nyumc.org
Zohrabian
Vahe M
VM
Grossman
Robert I
RI
D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000639:trends; D008833:Microcirculation / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis / Q000473:pathology*