The GTPase Ran: regulation of cell life and potential roles in cell transformation.
The GTPase Ran plays a crucial role in nucleo-cytoplasmic transport of tumor suppressors, proto-oncogenes, signaling molecules and transcription factors. It also plays direct roles in mitosis, through which it regulates faithful chromosome segregation and hence the generation of genetically stable cells. Ran operates through a group of effector proteins. In this review we summarize growing evidence suggesting that deregulated activity of Ran or its effectors can contribute to pathways of cell transformation and facilitate tumor progression.
Rensen
Wilhelmina M
WM
Institute of Molecular Biology and Pathology, CNR National Research Council, c/o Department of Genetics and Molecular Biology, Sapienza University of Rome, via degli Apuli 4, 01185 Rome, Italy.
Mangiacasale
Rosamaria
R
Ciciarello
Marilena
M
Lavia
Patrizia
P
D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002468:Cell Physiological Phenomena; D002471:Cell Transformation, Neoplastic; D002477:Cells / Q000166:cytology; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D020690:GTPase-Activating Proteins / Q000378:metabolism; D020662:Guanine Nucleotide Exchange Factors / Q000502:physiology; D006801:Humans; D028884:Karyopherins / Q000502:physiology; D008938:Mitosis / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology; D009857:Oncogenes; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D020931:ran GTP-Binding Protein / Q000378:metabolism*; D000097606:Exportin 1 Protein
D018797:Cell Cycle Proteins; D020558:GTP Phosphohydrolases; D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; D028884:Karyopherins; D009687:Nuclear Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D020931:ran GTP-Binding Protein; D000097606:Exportin 1 Protein; C062521:RCC1 protein, human