[Case of domestically infected hepatitis E with marked thrombocytopenia].
A 52-year-old man was admitted to our hospital for fever, jaundice, and general malaise. Laboratory data revealed elevated serum liver enzyme levels (AST 2377IU/L, ALT 2756IU/L) and bilirubin (T-Bil 3.7 mg/dl). Blood count showed a marked decrease of platelets (2.0 x 10(4)/microl). Serological and virological analysis showed positive results for HEV IgM and HEV RNA, indicating a diagnosis of acute hepatitis E. The serum ferritin level was also markedly elevated (23200 ng/ml). A diagnosis of virus associated hemophagocytic syndrome (VAHS) was strongly suggested. This is the first report of hepatitis E most likely accompanied by VAHS.
Kamihira
Takashi
T
Department of Gastroenterology, NHO National Nagasaki Medical Center, Omura, Nagasaki.
Yano
Koji
K
Tamada
Yoko
Y
Matsumoto
Takehiro
T
Miyazato
Masaru
M
Nagaoka
Sinya
S
Ohata
Kazuyuki
K
Abiru
Seigo
S
Komori
Atsumasa
A
Daikoku
Manabu
M
Yatsuhashi
Hiroshi
H
Ishibashi
Hiromi
H
D015415:Biomarkers / Q000032:analysis; D006508:Hepatitis Antibodies / Q000032:analysis; D016751:Hepatitis E / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D016752:Hepatitis E virus / Q000235:genetics / Q000276:immunology; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis; D013921:Thrombocytopenia / Q000175:diagnosis / Q000209:etiology*
D015415:Biomarkers; D006508:Hepatitis Antibodies; D012367:RNA, Viral