Hippocampal volume and 2-year outcome in depression.
Although the hippocampus has been found to be smaller in people with depression, the clinical relevance of this is unclear. We investigated hippocampal volume (using high-resolution magnetic resonance imaging) and 2-year outcome in 57 patients with major depression. The left and right hippocampal volumes of patients with a depression relapse were significantly smaller than those of healthy controls. Our results support the hypothesis that the hippocampus is crucial in the outcome of depression.
Kronmüller
Klaus-Thomas
KT
Department of Psychiatry, University of Heidelberg, Vossstrasse 4, Heidelberg 69115, Germany. klaus_kronmueller@med.uni-heidelberg.de
Pantel
Johannes
J
Köhler
Sebastian
S
Victor
Daniela
D
Giesel
Frederik
F
Magnotta
Vincent A
VA
Mundt
Christoph
C
Essig
Marco
M
Schröder
Johannes
J
D000293:Adolescent; D000328:Adult; D003865:Major Depressive Disorder / Q000473:pathology* / Q000503:physiopathology; D016021:Epidemiologic Studies; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012008:Recurrence; D012737:Sex Factors