Childhood multifocal acquired demyelinating sensory and motor neuropathy.
We report the first pediatric cases of multifocal acquired demyelinating sensory and motor neuropathy with electrophysiologic evidence of proximal conduction abnormalities but no definite conduction block. Intravenous immunoglobulin caused clinical improvement followed by long-term remission without maintenance therapy; one patient has exhibited a monophasic course and the other has had a single relapse during the last 5 years. These cases suggest that there may be a long-term sustained beneficial effect of intravenous immunoglobulin therapy for children with this neuropathy.
Department of Pediatrics, Ehime Prefecture Central Hospital, Kasuga-cho 83, Matsuyama-shi, Ehime Prefecture 798-0024, Japan. c-hwakamoto@eph.pref.ehime.jp
Hiroyuki
H
Wakamoto
Aya
A
Chisaka
Naozou
N
Inoue
Naoko
N
Nakano
D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D004576:Electromyography; D005260:Female; D005528:Foot; D015417:Hereditary Sensory and Motor Neuropathy / Q000503:physiopathology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D018908:Muscle Weakness / Q000209:etiology; D009431:Neural Conduction / Q000502:physiology; D009460:Neurologic Examination; D010292:Paresthesia / Q000209:etiology / Q000503:physiopathology; D011241:Prednisone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D016756:Immunoglobulins, Intravenous; D011241:Prednisone