Antimycotic activity of 4-thioisosteres of flavonoids towards yeast and yeast-like microorganisms.
Different substituted methoxy- and hydroxy-4-thioisosteres of flavonoids were prepared and their in vitro antimycotic activity towards yeast (Candida spp., Clavispora spp., Cryptococcus spp., Filobasidiella spp., Issatchenkia spp., Pichia spp., Kluyveromyces spp., Saccharomyces spp. and Yarrowia spp.) and yeast-like (Prototheca spp.) microorganisms was tested. Further insights in the biological activities of these antioxidant, oestrogenic and antimicrobial biomimetic derivatives were obtained.
Buzzini
Pietro
P
Dipartimento di Biologia Applicata, Sezione di Microbiologia, Università di Perugia, Borgo XX Giugno 74, 06121 Perugia, Italy.
Menichetti
Stefano
S
Pagliuca
Chiara
C
Viglianisi
Caterina
C
Branda
Eva
E
Turchetti
Benedetta
B
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D002175:Candida / Q000378:metabolism*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003454:Cryptococcus / Q000378:metabolism; D015195:Drug Design; D004952:Esters / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D007716:Kluyveromyces / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D010843:Pichia / Q000378:metabolism; D012440:Saccharomyces / Q000378:metabolism; D025062:Yarrowia / Q000378:metabolism
D000935:Antifungal Agents; D004952:Esters; D005419:Flavonoids