[Cystatins: cysteine proteases regulation and disturbances in tumors and inflammation].
Cystatin C belongs to the group of wide spread extracellular cysteine protease inhibitors. Using ELISA kits it was shown that the highest cystatin C concentration was in human cerebrospinal fluid and low cystatin C concentration was in human urine. In healthy young persons serum cystatin C concentration was lower than in elder patients (50-65 year old). In patients with hemoblastoses (lymphoma, lymphogranulomatosis) increased serum cystatin C concentration was normalized after effective antitumor therapy. According to these data one can conclude that serum cystatin C concentration can be used as one of the prognostic criteria in patients with several kinds of hemoblastoses.
Korolenko
T A
TA
Filatova
T G
TG
Cherkanova
M S
MS
Khalikova
T A
TA
Bravve
I Iu
IIu
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D002648:Child; D055316:Cystatin C; D015891:Cystatins / Q000032:analysis*; D006689:Hodgkin Disease / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D007249:Inflammation / Q000175:diagnosis / Q000378:metabolism*; D007938:Leukemia / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000378:metabolism*; D011237:Predictive Value of Tests
D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins