Parathyroid hormone is inversely related to endothelin-1 in patients on haemodialysis.
OBJECTIVE
Parathyroid hormone secretion is mainly influenced by hypocalcaemia, hyperphosphataemia and vitamin D deficiency. However, previous in vitro and in vivo studies showed that endothelin-1 can influence parathyroid hormone secretion. This study was aimed at evaluating this relationship in vivo in uraemic patients.


METHODS
Parathyroid hormone and endothelin-1 plasma concentrations were measured in 67 haemodialysed patients. Patients with history of cardiovascular diseases and those with parathyroid adenoma were excluded.


RESULTS
Plasma levels of endothelin-1 were found to be inversely related to those of parathyroid hormone (P < 0.04) The multiple regression analysis, carried out considering parathyroid hormone as a dependent variable, and including age, sex, blood pressure, calcium x phosphorus product, and endothelin-1, demonstrated that the independent correlates of parathyroid hormone were endothelin-1 (beta = -0.276; P = 0.015), and calcium x phosphorus product (beta = 0.417; P < 0.0001).


CONCLUSIONS
For the first time in vivo, we demonstrated an inverse independent relationship between endothelin-1 and parathyroid hormone in haemodialysed patients. Because both endothelin-1 and parathyroid hormone are endowed with well-known harmful actions on cardiovascular apparatus, whether such inverse relation may really influence the natural history of cardiovascular damage due to secondary hyperparathyroidism remains to be elucidated.
Cattedra di Nefrologia, Dipartmento di Medicina Interna, Mallattie Cardiovasculari e NefroUrologiche, Hypertension Excellence Centre of the European Society of Hypertension, Università degli Studi di Palermo, Italy.
Alessandro
A
Palermo
Giuseppe
G
Mulè
Marco
M
Guarneri
Rosalia
R
Arsena
Raffaella
R
Riccobene
Maria Carmela
MC
Lorito
Francesco
F
Vaccaro
Giovanni
G
Cerasola
Santina
S
Cottone
D000328:Adult; D000368:Aged; D019332:Endothelin-1 / Q000097:blood* / Q000502:physiology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D012044:Regression Analysis; D006435:Renal Dialysis
D019332:Endothelin-1; C470125:PTH protein, human; D010281:Parathyroid Hormone