A case report of a renal mixed epithelial and stromal tumor in a heterozygous S1P2 receptor deficient mouse.
We report a case of mixed epithelial and stromal tumor of the kidney (MESTK) in a 32-week-old heterozygous sphingosine 1-phosphate-2 (S1P2) receptor deficient female mouse. A white solid mass replacing the left kidney was observed at the left retroperitoneal wall. Histologically, the tumor mass consisted of dimorphic cellular components of epithelial and stromal cells. Epithelial cells formed various sized irregular-shaped tubular structures resembling renal tubules surrounded by stromal cells. Immunohistochemically, epithelial cells were positive for cytokeratin, while stromal cells showed positive immunoreactivity with alpha-smooth muscle actin as well as vimentin. Based on the morphological and immunohistochemical findings, this tumor was diagnosed as a MESTK.
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan. msysbata@yahoo.co.jp
Masayoshi
M
Takabatake
Yoh
Y
Takuwa
Noriko
N
Takuwa
Hironobu
H
Yasuno
Sayaka
S
Matsumoto
Makoto
M
Shibutani
Kunitoshi
K
Mitsumori
D000818:Animals; D005038:Ethylnitrosourea; D005260:Female; D017353:Gene Deletion; D006579:Heterozygote; D007680:Kidney Neoplasms / Q000145:classification* / Q000473:pathology; D051379:Mice; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology*; D049349:Receptors, Lysosphingolipid / Q000235:genetics*
D049349:Receptors, Lysosphingolipid; D005038:Ethylnitrosourea