RNASET2 as a tumor antagonizing gene in a melanoma cancer model.
The RNASET2 gene, mapped in 6q27, was previously found to exert control of tumorigenesis in an ovarian cancer system. We present here results indicating a similar control in a melanoma cancer model. Thus, this gene is most likely involved in a common general pathway of tumorigenesis. Moreover, its antitumorigenic activity is manifested in vivo but not in vitro, suggesting that this gene belongs to the growing category of tumor antagonizing/malignancy suppressor genes. A possible role of RNASET2 in the activation of a senescence program, whose responsible locus was mapped in the same chromosomal 6q27 region, seems to be inconsistent with our data.
Department of Biotechnology and Molecular Sciences, University of Insubria, Varese, Italy.
Laura
L
Monti
Monica
M
Rodolfo
Monica
M
Rudolfo
Girieca
G
Lo Russo
Douglas
D
Noonan
Francesco
F
Acquati
Roberto
R
Taramelli
D000818:Animals; D015152:Blotting, Northern; D049109:Cell Proliferation; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D004195:Disease Models, Animal; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D015316:Genetic Therapy; D006801:Humans; D008546:Melanoma, Experimental / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008819:Mice, Nude; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012260:Ribonucleases / Q000235:genetics*; D014407:Tumor Cells, Cultured; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D023041:Xenograft Model Antitumor Assays
D012333:RNA, Messenger; D025521:Tumor Suppressor Proteins; D012260:Ribonucleases; C425232:RNASET2 protein, human