Taxanes and gene expression in breast cancer cells.
We analyzed expression of genes participating in apoptotic and oncogenesis processes under influence of paclitaxel applied in treatment of breast carcinoma. Analysis showed, that in a group of cells where paclitaxel was administered at lower dose (60 ng/mL) it caused statistically significant increase of expression of pro and antiapoptotic genes, genes coding caspases and oncogenes in comparison to control group.
Rzymowska
Jolanta
J
Department of Biology and Genetics, Medical University, Lublin, Poland.
Maj
Piotr
P
Niemczyk
Maciej
M
Malewski
Tadeusz
T
Wilkołaski
Andrzej
A
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics; D020169:Caspases / Q000187:drug effects; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D009857:Oncogenes / Q000187:drug effects; D017239:Paclitaxel / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D020169:Caspases; D017239:Paclitaxel