In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy.
Polymyxin B, minocycline, and tigecycline were the most potent of 10 antibiotics against 170 isolates of multidrug-resistant Acinetobacter baumannii. In time-kill studies, the exposure of a highly tigecycline-resistant isolate to tigecycline resulted in enhanced susceptibility to amikacin and synergistic bactericidal activities of the two drugs.
Moland
Ellen S
ES
Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68178, USA.
Craft
David W
DW
Hong
Seong-geun
SG
Kim
Soo-young
SY
Hachmeister
Lucas
L
Sayed
Shimon D
SD
Thomson
Kenneth S
KS
D040981:Acinetobacter baumannii / Q000187:drug effects*; D000583:Amikacin / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D000078304:Tigecycline
D000078304:Tigecycline; D000583:Amikacin; D008911:Minocycline