Structural changes for adult-born dentate granule cells after status epilepticus.
Status epilepticus (SE) not only results in an increased number of newly generated neurons in the dentate gyrus but also leads to structural alterations of many of these newborn granule cells. One of the structural changes involving newly generated dentate granule cells is the formation of hilar basal dendrites that persist on mature granule cells and integrate into synaptic circuitry. SE also causes other newborn granule cells to migrate ectopically into the hilus, and these cells also integrate into synaptic circuitry. This article will describe these structural alterations of granule cells found in the dentate gyrus after SE and will also discuss the time course of these events and possible underlying causes.
Department of Anatomy and Neurobiology, University of California, Irvine, California 92697-1275, USA.
Lee A
LA
Shapiro
Charles E
CE
Ribak
Sebastian
S
Jessberger
D053687:Adult Stem Cells / Q000166:cytology* / Q000502:physiology; D000818:Animals; D018891:Dentate Gyrus / Q000166:cytology* / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000502:physiology; D013226:Status Epilepticus / Q000473:pathology*