Hemostatic and inflammatory risk factors for intracerebral hemorrhage in a pooled cohort.
OBJECTIVE
The purpose of this study was to identify novel risk factors for intracerebral hemorrhagic stroke (ICH).


METHODS
Risk factors were assessed at baseline in a pooled cohort of the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS) involving 21,680 adults aged 45 or over. Over 263,489 person-years of follow-up, we identified 135 incident ICH events.


RESULTS
In multivariable models, for each SD higher baseline level of fibrinogen, the relative rate of incident ICH increased 35% (95% CI, 17% to 55%). Fibrinogen was more strongly related to ICH in ARIC than in CHS. In multivariable models, those with von Willebrand factor levels above the median were 1.72 (95% CI, 0.97 to 3.03) times more likely to have an incident ICH as those below the median. Factor VIII was significantly positively related to ICH in ARIC (relative rate per standard deviation of 1.31; 95% CI, 1.07 to 1.62), but not in CHS. There was no relation in multivariable models between lipoprotein (a), Factor VII, white blood cell count, or C-reactive protein and ICH.


CONCLUSIONS
Greater plasma fibrinogen and, to some degree, von Willebrand factor were associated with increased rates of ICH in these prospective studies, whereas Factor VIII was related to ICH in younger ARIC study participants only.
Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, 1300 S Second St, Minneapolis, MN 55454-1015, USA.
Jared D
JD
Sturgeon
Aaron R
AR
Folsom
W T
WT
Longstreth
Eyal
E
Shahar
Wayne D
WD
Rosamond
Mary
M
Cushman
D017677:Age Distribution; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000453:epidemiology* / Q000276:immunology; D015331:Cohort Studies; D005169:Factor VIII / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D007958:Leukocyte Count; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000453:epidemiology* / Q000276:immunology; D014481:United States / Q000453:epidemiology; D014657:Vasculitis / Q000097:blood / Q000453:epidemiology / Q000276:immunology; D014841:von Willebrand Factor / Q000378:metabolism*
D015415:Biomarkers; D017270:Lipoprotein(a); D014841:von Willebrand Factor; D005169:Factor VIII; D005340:Fibrinogen; D002097:C-Reactive Protein