Homoallyllic nitrone isomerization: convenient enantioselective synthesis of homoallylic nitrones and homoallylic hydroxylamines.
An alpha-regioselective synthesis of homoallylic nitrones from aldehydes is reported on the basis of [3,3]-sigmatropic rearrangement. The products are obtained in up to 99% enantioselectivity and up to 80% yield under environmentally benign and mild reaction conditions.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637616.
Hin-Soon
HS
Cheng
Ai-Hua
AH
Seow
Teck-Peng
TP
Loh