Old and new questions about cholinesterases.
Cholinesterases have been intensively studied for a long time, but still offer many fascinating and fundamental questions regarding their evolution, activity, biosynthesis, folding, post-translational modifications, association with structural proteins (ColQ, PRiMA and maybe others), export or degradation. They constitute an excellent model to study these processes, particularly because of the sensitivity and specificity of enzymic assays. In addition, a number of provocative ideas concerning their proposed non-conventional, or non-catalytic functions deserve to be further documented.
Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Supérieure, 46 rue d'Ulm, Paris, France. jean.massoulie@biologie.ens.fr
Jean
J
Massoulié
Noël
N
Perrier
Hiba
H
Noureddine
Dong
D
Liang
Suzanne
S
Bon
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D055162:Biocatalysis; D002448:Cell Adhesion; D002454:Cell Differentiation; D002802:Cholinesterases / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008969:Molecular Sequence Data; D018384:Oxidative Stress
D002802:Cholinesterases