n-3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects.
Dietary n-3 fatty acids, particularly eicosapentaenoic acid and docosahexaenoic acid, are important nutrients through the life cycle. Evidence from observational, clinical, animal, and in vitro studies indicates a beneficial role of n-3 fatty acids in the prevention and management of cardiovascular disease. Although the precise mechanisms are still unclear, clinical and preclinical studies indicate that the cardioprotective effects of n-3 fatty acids may be attributed to a number of distinct biological effects on lipid and lipoprotein metabolism, blood pressure, platelet function, arterial cholesterol delivery, vascular function, and inflammatory responses.
Jung
Un Ju
UJ
Department of Pediatrics, Institute of Human Nutrition, College of Physicians and Surgeons of Columbia University, and Scientiae, LLC, New York, NY 10032, USA.
Torrejon
Claudia
C
Tighe
Ann P
AP
Deckelbaum
Richard J
RJ
D000818:Animals; D050197:Atherosclerosis / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000401:mortality / Q000517:prevention & control*; D016757:Death, Sudden, Cardiac / Q000517:prevention & control; D004044:Dietary Proteins; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005395:Fish Oils / Q000627:therapeutic use; D005399:Fishes; D006801:Humans; D006973:Hypertension / Q000517:prevention & control; D009203:Myocardial Infarction / Q000517:prevention & control
D004044:Dietary Proteins; D015525:Fatty Acids, Omega-3; D005395:Fish Oils