Synthesis of some new quinazolin-4-one derivatives and evaluation of their antimicrobial and antiinflammatory effects.
In this work, it was of interest to synthesize new series of some 2-[(E)-2-furan-2-yl-vinyl]-quinazolin-4(3H)-ones incorporated into pyrazoline, isoxazoline, pyrimidine or pyrimidine-thione ring systems at position-3 of the quinazoline ring. The antimicrobial activity and antiinflammatory effect of some of these compounds were studied.
Department of Medicinal Chemistry, National Research Centre, Dokki, Cairo, Egypt.
Omar Abd El-Fattah M
OA
Fathalla
Emad M M
EM
Kassem
Neama M
NM
Ibrahem
Mohsen M
MM
Kamel
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008826:Microbial Sensitivity Tests; D011799:Quinazolines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D011799:Quinazolines; D007213:Indomethacin