Lymphatics in lung disease.
The lymphatic circulation appears to be a vital component in lung biology in health and in disease. Animal models have established the role of the lymphatic circulation in neoplastic and inflammatory diseases of the lung, such as asthma and cancer, and allowed for the understanding of the molecular controls of lymphangiogenesis in normal lung development. Understanding the role of lymphatics in human lung disease appears likely to contribute to the understanding of the pathogenesis of disease and the development of novel therapeutic targets.
Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg. 10, Rm 6D03, MSC 1590, Bethesda, MD 20892-1590, USA.
Souheil
S
El-Chemaly
Stewart J
SJ
Levine
Joel
J
Moss
D006801:Humans; D008171:Lung Diseases / Q000473:pathology*; D042583:Lymphangiogenesis / Q000235:genetics / Q000502:physiology; D008207:Lymphatic Metastasis / Q000473:pathology; D008208:Lymphatic System / Q000473:pathology*; D042582:Vascular Endothelial Growth Factor C / Q000502:physiology; D042643:Vascular Endothelial Growth Factor D / Q000502:physiology
D042582:Vascular Endothelial Growth Factor C; D042643:Vascular Endothelial Growth Factor D