Small rounded B-cell lymphoma of bone presented by limp, with a positive multifocal 99mTc MDP bone scintigraphy pattern and a negative 99mTc HMPAO-labeled leukocytes study.
In this article, we present a rare case of B-cell bone lymphoma in a child with multifocal asymptomatic lesions detected by bone scintigraphy and a chronic clinical history characterized by limping and fever episodes for over a year. Initially, multifocal osteomyelitis was suspected and antibiotic therapy was administered with no clinical improvement. The biopsy of the main lesion in the left distal femur along with bone marrow cytology established the final diagnosis. This rare case illustrates the utility of routinely low cost-effective nuclear medicine studies like whole body bone scan and 99mTc hexamethylpropyleneamine oxime-labeled leukocytes to orientate similar cases to a correct diagnosis.
Department of Nuclear Medicine, General University Hospital Gregorio Marañon, Madrid, Spain. rubenhernandezperez@yahoo.es
Ruben Hernandez
RH
Perez
Juan Carlos
JC
Alonso Farto
Isabel Almoguera
IA
Arias
Amanda Rotger
AR
Regi
Jose Manuel
JM
Perez Vazquez
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005684:Gait; D006801:Humans; D007962:Leukocytes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D010019:Osteomyelitis / Q000000981:diagnostic imaging / Q000473:pathology; D011877:Radionuclide Imaging; D019690:Technetium Tc 99m Exametazime; D013669:Technetium Tc 99m Medronate
D000970:Antineoplastic Agents; D019690:Technetium Tc 99m Exametazime; D013669:Technetium Tc 99m Medronate