Anti-cancer potential of gold complexes.
A full range of gold compounds is currently being investigated for their potential as anti-tumor agents. Gold(I) compounds related to the anti-arthritic drug continue to attract attention, especially those carrying biologically active molecules with anti-tumor activity in their own right. Tetrahedrally coordinated gold(I) compounds, that possibly target mitochondria, are under development with a particular focus upon moderating their hydrophilicity. A resurgence of interest in square-planar gold(III) compounds has occurred in the last decade. A wide variety of species: mono- and di-nuclear, neutral and charged, coordination and organometallic, etc. are being developed. Supporting many investigations are studies of mechanistic aspects of gold compounds but a clear understanding of the mechanism of action of these compounds has yet to be delineated.
Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas, 78249-0698, USA. Edward.Tiekink@utsa.edu
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D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001310:Auranofin / Q000031:analogs & derivatives; D006801:Humans; D050607:Organogold Compounds / Q000494:pharmacology*
D000970:Antineoplastic Agents; D050607:Organogold Compounds; D001310:Auranofin