Use of topical selamectin for the treatment of Syphacia muris infection in laboratory rats.
Efficacy of selamectin was studied in naturally acquired S. muris infections in rats. Fourty-eight S. muris-positive rats were divided into six treated and two control groups. Selamectin (6 mg/kg) was applied topically to the skin in a single spot at the base of the neck in the treatment group. The rats of treated and control groups were necropsied on the 24th day after the treatment. Topical selamectin was found to be 40.7-63.3% effective (based on egg per gram method) in eliminating S. muris infection in rats. The efficacy of the treatment against S. muris (based on adult worm counts) in male and female rats was 35.14-58.88%, respectively (mean 48.39%).
Department of Parasitology, Faculty of Veterinary Medicine, Istanbul University, 34310 Avcilar, Istanbul, Turkey. breeze@istanbul.edu.tr
M U
MU
Esatgil
A
A
Gülanber
H
H
Aydin
D000818:Animals; D000830:Animals, Laboratory; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D010124:Oxyuroidea; D010270:Parasite Egg Count / Q000662:veterinary; D051381:Rats; D017207:Rats, Sprague-Dawley; D012376:Rodent Diseases / Q000188:drug therapy / Q000469:parasitology*
D000871:Anthelmintics; D007559:Ivermectin; C414354:selamectin