Challenges in the use of carbon nanotubes for biomedical applications.
Carbon nanotubes (CNTs) are considered for use in numerous technological applications, including as biocompatible modules for the delivery of bioactives. However, there are unique properties of CNTs that limit their use as vehicles for various purposes. This review highlights the various challenges to a pharmaceutical scientist while exploring CNTs as bioactive delivery vehicles. The lack of solubility, nonbiodegradability, circulation half-life of 3-3.5 hours, biocompatibility, and immunogenicity limitations of CNTs are discussed in this review. These limitations indicate the need for modifications in order to explore the feasibility of CNTs as delivery vehicles.
Mehra
Neelesh Kumar
NK
Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar-470003, India.
Jain
Amit Kumar
AK
Lodhi
Neeraj
N
Raj
Rakesh
R
Dubey
Vaibhav
V
Mishra
Dinesh
D
Nahar
Manoj
M
Jain
Narendra Kumar
NK
D000818:Animals; D001672:Biocompatible Materials; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D006207:Half-Life; D006801:Humans; D036103:Nanotechnology; D037742:Nanotubes, Carbon; D012995:Solubility; D014612:Vaccines / Q000008:administration & dosage
D001672:Biocompatible Materials; D037742:Nanotubes, Carbon; D014612:Vaccines