Psychological stress induces hypoferremia through the IL-6-hepcidin axis in rats.
Anemia is a widespread public health problem. The psychological stress decreases serum iron level and inhibits erythropoiesis. However, the molecular mechanisms involved, leading to iron mal-regulation are not well known. We used a communication box paradigm to induce psychological stress and found that serum iron level decreased after 3d while liver iron storage increased after 7d. Moreover, psychological stress up-regulated expressions of interleukin-6 (IL-6) and hepcidin, while down-regulating ferroportin expression after 3d. These changes were blocked by the injection of IL-6 monoclonal antibody. In conclusion, the IL-6-hepcidin axis is up-regulated by psychological stress in rats, resulting in hypoferremia and increase of hepatic iron storage.
Department of Naval Medicine, Second Military Medical University, 800 Xiangxin Road, Shanghai 200433, PR China.
Min
M
Zhao
Jianbo
J
Chen
Wanyin
W
Wang
Lei
L
Wang
Long
L
Ma
Hui
H
Shen
Min
M
Li
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism*; D027682:Cation Transport Proteins / Q000378:metabolism; D015536:Down-Regulation; D064451:Hepcidins; D015850:Interleukin-6 / Q000378:metabolism*; D007501:Iron / Q000097:blood* / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological / Q000097:blood* / Q000378:metabolism*; D015854:Up-Regulation; D000098742:Ferroportin; D000093242:Interleukin-6 Inhibitors
D000911:Antibodies, Monoclonal; D023181:Antimicrobial Cationic Peptides; D027682:Cation Transport Proteins; D064451:Hepcidins; D015850:Interleukin-6; D007501:Iron; D000098742:Ferroportin; D000093242:Interleukin-6 Inhibitors; C578703:Hamp protein, rat