Evaluation of inflammatory kinin-forming components in experimental epilepsy in rats.
The study was conducted to evaluate the total and active brain tissue kallikrein levels as well as plasma kininogen concentrations in the experimental models of epilepsy induced by maximal electroshock (MES), submaximal electroshock (SMES) and pentylenetetrazole (PTZ) in adult Sprague-Dawley rats. There was significant increase in the total brain tissue kallikrein (P < 0.001) and active tissue kallikrein (P < 0.05) after MES, SMES and PTZ induced epilepsy. Also, the total plasma kininogen levels fell significantly (P < 0.05) after production of MES, SMES and PTZ epilepsy. These results may suggest that these changes may indicate the formation of proinflammatory mediator, kinins, in the brain and peripheral circulation in experimental epilepsy.
Department of Applied Therapeutics, Faculty of Pharmacy, Health Sciences Centre, Kuwait University, Safat, 13110, Kuwait. j.n.sharma@hsc.edu.kw
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Sharma
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Kadir
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Uma
D000818:Animals; D001923:Brain Chemistry; D004827:Epilepsy / Q000378:metabolism*; D007610:Kallikreins / Q000032:analysis*; D007704:Kininogens / Q000097:blood*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D007704:Kininogens; D007610:Kallikreins