Potential role of CD8+CD28- T lymphocytes in immune activation during HIV-1 infection.
As CD8+CD28- T cells have been associated with dendritic and T cell suppression, we analyzed whether an increase in CD8+CD28- T cell numbers during HIV-1 infection could lead to impaired T cell responses. In contrast to the in-vitro generated CD8+CD28- suppressors, peripheral blood CD8+CD28- T cells of both HIV-infected and noninfected individuals promoted dendritic cell activation. The CD8+CD28- T cell accumulation during HIV-1 infection may thus contribute to accelerated inflammatory reactions and immune activation.
Department of Microbiology, Cell and Tumor Biology, Karolinska Institute, Stockholm, Sweden.
Nancy
N
Vivar
Pham Hong
PH
Thang
Ann
A
Atlas
Francesca
F
Chiodi
Bence
B
Rethi
D018106:CD28 Antigens / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000378:metabolism*; D051858:Forkhead Transcription Factors / Q000378:metabolism; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy
D018106:CD28 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors