The role of abnormal vitreomacular adhesion in age-related macular degeneration: spectral optical coherence tomography and surgical results.
OBJECTIVE
To assess the incidence of vitreomacular adhesion and traction in age-related macular degeneration (AMD), and to evaluate surgical treatment in a subset of patients with choroidal neovascularization (CNV) nonresponsive to anti-neovascular growth factor (anti-VEGF) treatment.


METHODS
Retrospective observational case-control and interventional case series.


METHODS
Spectral optical coherence tomography, combined with simultaneous scanning laser ophthalmoscope (Spectral OCT/SLO), was performed in 170 eyes of 94 elderly patients, 61 with exudative AMD, 59 with nonexudative AMD, and 50 control eyes. The presence of hyaloid adhesion to the posterior pole, and vitreomacular traction (VMT) were determined. Five patients with VMT underwent surgical hyaloid removal. Best-corrected visual acuity (BCVA) and retinal thickness were evaluated as outcomes.


RESULTS
Hyaloid adhesion was present in 17 eyes with exudative AMD (27.8%), 15 eyes with nonexudative AMD (25.4%), and eight control eyes (16%). Significant difference was found among the groups (P = .002). Among the eyes with hyaloid adhesion, VMT was shown in 10 eyes (59%) with exudative AMD, two eyes (13%) with nonexudative AMD, and one control eye (12%). VMT was associated with the severity of AMD (P = .0082). The area of hyaloid adhesion was significantly smaller than and concentric to the area of CNV complex in eyes with exudative AMD. Eyes with VMT that underwent surgery experienced a modest improvement of BCVA and decrease of retinal thickness.


CONCLUSIONS
Hyaloid adhesion to the macula is associated with AMD, and frequently causes VMT in eyes with CNV. Tractional forces may antagonize the effect of anti-VEGF treatment, and cause pharmacological resistance in a subpopulation of patients. Future studies are needed to define the role of vitreoretinal surgery in such cases. Spectral OCT/SLO allows careful diagnosis and follow-up.
Jacobs Retina Center at the Shiley Eye Center, Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Francesca
F
Mojana
Lingyun
L
Cheng
Dirk-Uwe G
DU
Bartsch
Gabriel A
GA
Silva
Igor
I
Kozak
Nitin
N
Nigam
William R
WR
Freeman
D000368:Aged; D016022:Case-Control Studies; D020256:Choroidal Neovascularization / Q000209:etiology; D005122:Exudates and Transudates; D005128:Eye Diseases / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000473:pathology* / Q000601:surgery; D008268:Macular Degeneration / Q000503:physiopathology*; D008297:Male; D009887:Ophthalmoscopy; D012189:Retrospective Studies; D000267:Tissue Adhesions / Q000503:physiopathology; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D014822:Vitreous Body / Q000473:pathology* / Q000601:surgery; D020255:Vitreous Detachment / Q000175:diagnosis