Anthrax-associated shock.
Recent events have brought attention to the potential of Bacillus anthracis as an agent of bioterrorism. The shock like state of anthrax is invariably associated with high mortality, despite anti-microbial and supportive therapy. Multi-system dysfunction is typical, including: enhanced vascular permeability, hemorrhage and inflammation. Important questions concerning the pathophysiology of anthrax-associated shock remain unanswered, including the effects of B. anthracis infection on cardiac function. This review discusses the current state of knowledge regarding the pathophysiology of anthrax-associated shock.
Goldman
David L
DL
Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10461, USA. dgoldma@aecom.yu.edu
Casadevall
Arturo
A
D000818:Animals; D000881:Anthrax / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology / Q000635:transmission; D000942:Antigens, Bacterial; D001408:Bacillus anthracis / Q000502:physiology; D001427:Bacterial Toxins; D023482:Bioterrorism; D016207:Cytokines / Q000502:physiology; D006321:Heart / Q000503:physiopathology; D006439:Hemodynamics; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology / Q000382:microbiology; D018805:Sepsis / Q000209:etiology; D012769:Shock / Q000209:etiology*; D013171:Spores, Bacterial / Q000472:pathogenicity; D015047:Zoonoses
D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D016207:Cytokines; C030325:anthrax toxin