[Muscle and bone health as a risk factor of fall among the elderly. Prevention of fracture and bisphosphonate].
Fracture risk reduction in patients with osteoporosis by nitrogen containing bisphosphonate (N-BP) has been well confirmed in the daily practices. N-BPs suppress bone resorption by inhibiting farnesyl diphosphate synthase in mevalonate pathway, reducing protein-prenylation, consequently disrupting the membrance structure in osteoclasts. A once-yearly infusion of zoledronic acid during 3-year period significantly reduced the risk of vertebral fracture by 70% and that of hip fracture by 41% in patients with postmenopausal osteoporosis at the mean age of 73. The annual infusion within 90 days after surgery was associated with a reduction the rate of new fractures and with improved survival. We may count N-BP as one of essential drugs in the health care for elderlies.
University of Occupational and Environmental Health, School of Medicine, Department of Orthopedic Surgery.
Toshitaka
T
Nakamura
D000368:Aged; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D050723:Fractures, Bone / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D008297:Male
D004164:Diphosphonates