Plasmid-mediated qnrB2 and carbapenemase gene bla(KPC-2) carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates.
Fourteen out of 16 carbapenem-resistant quinolone-susceptible Enterobacter cloacae isolates were found to carry qnrB2 and bla(KPC-2) genes encoded on the same plasmid. One isolate also carried the aac(6')-Ib-cr gene. Coexistence of quinolone resistance determinants and bla(KPC-2) on the same plasmid in quinolone-susceptible E. cloacae isolates may have important clinical implications.
Chmelnitsky
Inna
I
Division of Epidemiology, Tel-Aviv Medical Center, Tel Aviv, Israel.
Navon-Venezia
Shiri
S
Strahilevitz
Jacob
J
Carmeli
Yehuda
Y
D000890:Anti-Infective Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D015780:Carbapenems / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D016972:Enterobacter cloacae / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D005798:Genes, Bacterial / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics*; D015363:Quinolones / Q000494:pharmacology; D001618:beta-Lactamases / Q000235:genetics*
D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D015363:Quinolones; D002939:Ciprofloxacin; D001618:beta-Lactamases; C063912:carbapenemase