Alstilobanines A-E, new indole alkaloids from Alstonia angustiloba.
Five new alkaloids, alstilobanines A (1)-E (5) were isolated from Alstonia angustiloba (Apocynaceae) and their structures were determined by MS and 2D NMR spectral analysis. Alstilobanines A-E showed a moderate vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.
Koyama
Koichiro
K
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
Hirasawa
Yusuke
Y
Zaima
Kazumasa
K
Hoe
Teh Chin
TC
Chan
Kit-Lam
KL
Morita
Hiroshi
H
D031051:Alstonia / Q000737:chemistry*; D000818:Animals; D026121:Indole Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014664:Vasodilation / Q000187:drug effects
D026121:Indole Alkaloids