Effect of honey on bacterial translocation and intestinal morphology in obstructive jaundice.
OBJECTIVE
To evaluate the effects of honey on bacterial translocation and intestinal villus histopathology in experimental obstructive jaundice.


METHODS
Thirty Wistar-Albino rats were randomly divided into three groups each including 10 animals: group I, sham-operated; group II, ligation and section of the common bile duct (BDL); group III, bile duct ligation followed by oral supplementation of honey (BDL + honey) 10 g/kg per day. Liver, blood, spleen, mesenteric lymph nodes, and ileal samples were taken for microbiological, light and transmission electrone microscopic examination.


RESULTS
Although the number of villi per centimeter and the height of the mucosa were higher in sham group, there was no statistically significant difference between sham and BDL + honey groups (P > 0.05). On the other hand, there was a statistically significant difference between BDL group and other groups (P < 0.05). The electron microscopic changes were also different between these groups. Sham and honey groups had similar incidence of bacterial translocation (P > 0.05). BDL group had significantly higher rates of bacterial translocation as compared with sham and honey groups. Bacterial translocation was predominantly detected in mesenteric lymph nodes.


CONCLUSIONS
Supplementation of honey in presence of obstructive jaundice ameliorates bacterial translocation and improves ileal morphology.
Ankara Training and Research Hospital, 4th General Surgery Department, 06340, Ulucanlar, Ankara 06370, Turkey.
Cem
C
Gencay
Sibel-Serin
SS
Kilicoglu
Kemal
K
Kismet
Bulent
B
Kilicoglu
Serap
S
Erel
Sabahattin
S
Muratoglu
Asli-Elif
AE
Sunay
Esra
E
Erdemli
Mehmet-Ali
MA
Akkus
D000284:Administration, Oral; D000818:Animals; D018988:Bacterial Translocation / Q000187:drug effects*; D003135:Common Bile Duct / Q000601:surgery; D004195:Disease Models, Animal; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006722:Honey; D007082:Ileum / Q000187:drug effects* / Q000382:microbiology / Q000648:ultrastructure; D007413:Intestinal Mucosa / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000382:microbiology; D041781:Jaundice, Obstructive / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D008026:Ligation; D008198:Lymph Nodes / Q000187:drug effects* / Q000382:microbiology; D008297:Male; D008643:Mesentery; D051381:Rats; D017208:Rats, Wistar; D014463:Ultrasonography
D005765:Gastrointestinal Agents