Effects of TGFbeta1 and extracts from Cervus korean TEMMINCK var. mantchuricus Swinhoe on acute and chronic arthritis in rats.
OBJECTIVE
To elucidate the pharmacological activities of deer antler acupuncture and TGF61538;1 on the acute and chronic phases of rheumatoid arthritis diseases.


METHODS
Polyarthritis rats were administered with TGF61538;1 and water extract of deer antler acupunture (DAA), prepared from the pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe. TGF61538; (0.1 to 2 61549;g/animal) and DAA (5-100 61549;g/kg animal) were initiated 1 day before an arthritogenic dose of streptococcal cell wall fragments to see the effects on the joint swelling and distortion during the acute phase and the chronic phase of the disease. Arthritic index suppression of rat arthritis model was examined by TGF61538; and DAA administrations.


RESULTS
TGF61538;1 and DAA diminished the polyarthritis development in rats. TGF61538; and DAA eliminated the joint swelling and distortion observed during the acute phase and the chronic phase of the disease. The TGF61538; and DAA suppressed the arthritis progress when administration was begun after acute phase of arthritis.


CONCLUSIONS
Consistent with the inhibition of inflammatory cell recruitment into the synovium, TGF61538;1 and DAA reversed the leukocytosis associated with the chronic phase of the arthritis, respectively.
Kim
Kyung-Woon
KW
Department of Biological Science, Sungkyunkwan University, Chunchun-Dong 300, Suwon City, Kyunggi-Do 440-746, Republic of Korea.
Song
Kwon-Ho
KH
Lee
Ji-Min
JM
Kim
Kap-Sung
KS
Kim
Sung-Il
SI
Moon
Sung-Kwon
SK
Kang
Bong-Seok
BS
Kim
Dong-Soo
DS
Chung
Kang-Hyun
KH
Chang
Young-Chae
YC
Kim
Cheorl-Ho
CH
D000208:Acute Disease; D000818:Animals; D000999:Antlers / Q000737:chemistry*; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000503:physiopathology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000503:physiopathology; D002473:Cell Wall / Q000737:chemistry / Q000276:immunology; D002908:Chronic Disease; D003670:Deer; D004305:Dose-Response Relationship, Drug; D005260:Female; D051381:Rats; D011917:Rats, Inbred Lew; D013291:Streptococcus / Q000737:chemistry / Q000276:immunology; D013583:Synovial Membrane / Q000378:metabolism; D014020:Tissue Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D053773:Transforming Growth Factor beta1 / Q000008:administration & dosage / Q000494:pharmacology*
D014020:Tissue Extracts; D053773:Transforming Growth Factor beta1