Topiramate-induced psychosis in two members of the one family: a case report.
BACKGROUND
The use of topiramate has increased in recent years. It is now used by various specialties to treat a wide range of medical conditions. A small number of case reports describe psychosis as an adverse event of topiramate but most are in patients being treated for epilepsy and none describe a family history of this side effect.


METHODS
We present a case report of topiramate-induced psychosis in a patient with familial essential tremor, whose sister also developed this same adverse effect.


CONCLUSIONS
Physicians need to be aware of psychosis as a rare but debilitating side effect of this drug. Several predictors have been identified and a careful history, including family history, needs to be obtained prior to initiation of therapy to stratify the risk.
Department of Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Salford, UK. rjpj@ananzi.co.za
Ricardo Jorge Paixão
RJ
José
Alastair
A
Cairns
Christopher
C
Babbs