[Progress in the study of pH and temperature sensitive biodegradable block copolymers].
pH and temperature sensitive biodegradable block copolymers are some macromolecules connected by biodegradable materials and pH sensitive monomers according to a certain sequence, or biodegradable polyesters polymerized themselves. On the basis of pertinent documents, the development of pH and temperature sensitive biodegradable block copolymers was introduced, involving their mechanism of action and potential application. PH and temperature sensitive biodegradable block copolymers could control the drug release rate freely, avoiding burst effect. Besides, the biocompatibility of these biodegradable materials is also excellent. So the use of pH and temperature sensitive biodegradable block copolymers as biodegradable drug delivery devices has attracted considerable interest in the intelligent drug delivery system.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Tang-Na
TN
Hao
Ming-Xi
MX
Qiao
Zhen
Z
Li
Da-Wei
DW
Chen
D001672:Biocompatible Materials / Q000737:chemistry; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011098:Polyglactin 910 / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D013696:Temperature
D001672:Biocompatible Materials; D007773:Lactates; D011091:Polyesters; D011108:Polymers; C512884:poly(epsilon-caprolactone-co-lactide)-poly(ethylene glycol); C088513:poly(lactic acid-ethylene glycol); C520330:polyethylene glycol-poly(lactic-co-glycolic acid)-polyethylene glycol; C507889:polylactide-polyethylene glycol-polylactide; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011098:Polyglactin 910; D011092:Polyethylene Glycols; C033616:poly(lactide)