Inspiratory contrast for in vivo optical imaging.
We demonstrate the use of inspired oxygen and carbon dioxide as a possible route to increase contrast in optical imaging of cancerous tissue. Differential imaging in human xenograft rodent models of cancer exhibits significant variation in signal between normal and cancerous tissue. This differential cancer-specific contrast is stronger and more consistent than the conventional static contrast. This differential technique exploits the response of abnormal tumor vasculature to inhaled gases and could provide a promising alternative to supplement mainstream cancer imaging modalities such as x-rays and MRI.
Kotz
Kenneth T
KT
Molecular Physics Laboratory, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
Dixit
Sanhita S
SS
Gibbs
Ashley D
AD
Orduna
Juan M
JM
Haroon
Zishan
Z
Amin
Khalid
K
Faris
Gregory W
GW
D000280:Administration, Inhalation; D000818:Animals; D002245:Carbon Dioxide / Q000008:administration & dosage*; D003287:Contrast Media; D007089:Image Enhancement / Q000379:methods; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000473:pathology*; D010100:Oxygen / Q000008:administration & dosage*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D051598:Whole Body Imaging / Q000379:methods*
D003287:Contrast Media; D002245:Carbon Dioxide; D010100:Oxygen