[Behçet's disease].
Behçet's disease is a systemic vascularitis appearing primarily by an oral and/or genital aphtose and an uveitis, the unit constituting the tripod of call of the diagnosis having led to its initial description. But its clinical demonstrations are protean with other quasi-specific cutaneous signs and a whole panel of organic attacks, the complicated syndromic forms being the entero-, the angio- and the neuro-Behçet. Its diagnosis is sometimes difficult in the absence of clinical or biological specific signs, in particular when the tripod diagnosis is incomplete. The prognosis of this disease remains heavy, in particular on the ophthalmologic functional level, because of the absence of specific curative treatment, its etiology remaining ignored to date. However, ongoing therapeutic progress are observed for severe and refractory forms to conventional immunosuppressive drugs with the advent of anti-TNFalpha drugs of which the precise place in the therapeutic arsenal, still badly codified, and the long-term effectiveness remain to be specified.
Aouba
Achille
A
Université de Paris5 René-Descartes. achille.aouba@nck.aphp.fr
D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use; D001528:Behcet Syndrome / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy; D003078:Colchicine / Q000008:administration & dosage / Q000627:therapeutic use; D003348:Cortisone / Q000008:administration & dosage / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000069285:Infliximab; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011379:Prognosis; D012074:Remission Induction; D050257:Tubulin Modulators / Q000008:administration & dosage / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D050257:Tubulin Modulators; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab; D001241:Aspirin; D003078:Colchicine; D003348:Cortisone; D008775:Methylprednisolone