Reproducibility of TMS-Evoked EEG responses.
Navigated transcranial magnetic stimulation combined with electroencephalography (nTMS-EEG), allows noninvasive studies of cortical excitability and connectivity in humans. We investigated the reproducibility of nTMS-EEG in seven healthy subjects by repeating left motor and prefrontal cortical stimulation with a 1-week interval. TMS was applied at three intensities: 90, 100, and 110% of subjects' motor threshold (MT). The TMS-compatible neuronavigation system guaranteed precise repositioning of the stimulation coil. The responses were recorded by a 60-channel whole head TMS-compatible EEG amplifier. A high overall reproducibility (r > 0.80) was evident in nTMS-EEG responses over both hemispheres for both motor and prefrontal cortical stimulation. The results suggest that nTMS-EEG is a reliable tool for studies investigating cortical excitability changes in the test-retest designs.
Lioumis
Pantelis
P
HUSLAB, Hospital District of Helsinki and Uusimaa, Finland. plioumis@cc.hut.fi
Kicić
Dubravko
D
Savolainen
Petri
P
Mäkelä
Jyrki P
JP
Kähkönen
Seppo
S
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods*; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D011930:Reaction Time; D015203:Reproducibility of Results; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D055815:Young Adult