BRCT domains: phosphopeptide binding and signaling modules.
The BRCA1 C-terminus (BRCT) domains are essential for the tumor suppressor function of BRCA1, and have been found in a variety of proteins from bacteria to men. Recent studies demonstrate that the BRCT domain constitutes a novel phosphopeptide binding region. In this review we seek to discuss the recent biochemical and structural data that have helped elucidate the molecular basis of BRCT domain function and BRCT-mediated interactions, with special emphasis on the role of phospho-specific interactions in key networks that regulate DNA repair. Finally we offer predictions on additional phospho-interacting BRCT domains and potential in vivo binding sites for several BRCT domains.
1Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.
Maria C
MC
Rodriguez
Zhou
Z
Songyang
D019313:BRCA1 Protein / Q000737:chemistry* / Q000502:physiology; D001943:Breast Neoplasms / Q000235:genetics; D002352:Carrier Proteins / Q000378:metabolism; D004268:DNA-Binding Proteins; D004706:Endodeoxyribonucleases; D005260:Female; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D056488:Histone Chaperones; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000235:genetics; D010446:Peptide Fragments / Q000737:chemistry*; D010748:Phosphopeptides / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology*; D010750:Phosphoproteins / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction
C520310:ABRAXAS1 protein, human; D019313:BRCA1 Protein; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D056488:Histone Chaperones; D009687:Nuclear Proteins; D010446:Peptide Fragments; D010748:Phosphopeptides; D010750:Phosphoproteins; C466234:UIMC1 protein, human; D004706:Endodeoxyribonucleases; C410741:RBBP8 protein, human