Rescue of congenital hypomyelination by progenitor cell transplantation.
Replacement of myelin-forming cells is an attractive but unproven therapy for inherited and acquired myelin diseases. In this issue of Cell Stem Cell, Windrem et al. (2008) describe the first progenitor cell transplantation paradigm that rescues the neurological phenotypes and increases life spans of mice with inherited myelin disease.
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. trappb@ccf.org
Bruce D
BD
Trapp
D053687:Adult Stem Cells / Q000166:cytology / Q000378:metabolism / Q000637:transplantation*; D000818:Animals; D006801:Humans; D051379:Mice; D009186:Myelin Sheath / Q000235:genetics / Q000378:metabolism* / Q000637:transplantation*; D009422:Nervous System Diseases / Q000151:congenital / Q000628:therapy; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism / Q000637:transplantation*; D033581:Stem Cell Transplantation; D018183:Transplantation Chimera