Nitric oxide the gatekeeper of endothelial vasomotor control.
The endothelium can elicit relaxations and contractions of the underlying smooth muscle cells. It does so by releasing vasodilator (EDRF) and vasoconstrictor (EDCF) mediators. Among the diffusible endothelial factors nitric oxide (NO) plays a key role, particularly in large blood vessels. This chapter briefly reviews the interactions between NO and the other vasomotor signals released by the endothelial cells.
Department of Angiology, Institut de Recherches Servier, Suresnes, France.
Michel
M
Feletou
Eva H C
EH
Tang
Paul M
PM
Vanhoutte
D000818:Animals; D001685:Biological Factors / Q000502:physiology; D017630:Connexins / Q000502:physiology; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000378:metabolism; D019332:Endothelin-1 / Q000378:metabolism / Q000502:physiology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology*; D015221:Potassium Channels / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D050052:TRPC Cation Channels / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology
D001685:Biological Factors; D017630:Connexins; D019332:Endothelin-1; D015221:Potassium Channels; D050052:TRPC Cation Channels; D014665:Vasodilator Agents; C067410:endothelium-dependent hyperpolarization factor; D009569:Nitric Oxide; D003577:Cytochrome P-450 Enzyme System; D000254:Sodium-Potassium-Exchanging ATPase