Synthesis and anti-HIV activity of N'-nicotinoyl--3-(4'-hydroxy-3'-methylphenyl)-5-[substituted phenyl]-2-pyrazolines.
A series of N'-nicotinoyl-3-(4'-hydroxy-3'-methylphenyl)-5-(substituted phenyl)-2-pyrazolines were synthesized by the reaction between isoniazid (INH) and chalcones and were tested for their in vitro anti-HIV activity. Among them, compound (c) showed a promising anti-HIV activity in vitro against used strains (IIIB, ROD), with IC50 of both IIIB 5.7 microM and ROD 7.0 microM.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard University, Hamdard Nagar, New Delhi, 110062, India.
Mohamed A
MA
Ali
Mohammad Shahar
MS
Yar
Anees A
AA
Siddiqui
Dharmarajan
D
Sriram
Perumal
P
Yogeeswari
Erick
E
De Clercq
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D011720:Pyrazoles