Bovine tuberculosis as a model for human tuberculosis: advantages over small animal models.
For the development of vaccines and treatments against tuberculosis, animal models are needed. In this review, the pathogenesis and immune responses during human and bovine tuberculosis will be compared. Special attention will be paid to latency, because this feature has recently become the basis of specialized vaccines against latency antigens.
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, Utrecht, The Netherlands. i.vanrhijn@uu.nl
Ildiko
I
Van Rhijn
Jacques
J
Godfroid
Anita
A
Michel
Victor
V
Rutten
D000818:Animals; D002417:Cattle; D004195:Disease Models, Animal; D006801:Humans; D014376:Tuberculosis / Q000473:pathology* / Q000503:physiopathology*; D014380:Tuberculosis, Bovine / Q000473:pathology* / Q000503:physiopathology*