Computational analyses of TBC protein family in eukaryotes.
Tre-2/Bub2/Cdc16 domain-containing proteins (TBC proteins) participate in wide range cellular processes. With computational approaches, 137 non-redundant TBC proteins from five model organisms were identified and classified into 13 subfamilies base on molecular evolutionary tree. This phylogenetic analysis provides useful functional annotation of newly-identified TBC proteins and guides for further experimentation.
Hefei National Laboratory for Physical Science, Hefei, Anhui 230027, China.
Xinjiao
X
Gao
Changjiang
C
Jin
Yu
Y
Xue
Xuebiao
X
Yao
D020816:Amino Acid Motifs; D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000737:chemistry / Q000145:classification; D019295:Computational Biology / Q000379:methods*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000145:classification; D029721:Drosophila Proteins / Q000737:chemistry / Q000145:classification; D019143:Evolution, Molecular; D020690:GTPase-Activating Proteins / Q000737:chemistry* / Q000145:classification*; D006801:Humans; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D012441:Saccharomyces cerevisiae / Q000737:chemistry; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000145:classification; D016415:Sequence Alignment
D029742:Caenorhabditis elegans Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D020690:GTPase-Activating Proteins; D029701:Saccharomyces cerevisiae Proteins