[Interrelation of vasomotor effects in the endothelium of the cerebral and main arteries in obstructive pulmonary diseases].
We have investigated vasomotor activity of the trunk and cerebral arteries in mice with obstructive pulmonary diseases. It was established, that endothelial dysfunction depends on the form of pulmonary disease and has regional vascular features. It was determined, that the maximal disturbances are shown in mice with chronic obstructive pulmonary disease. It express as infringement of regional autonomy vasomotor effects and pathological paradoxical vasoconstriction of cerebral vessels. Bronchial asthma associates with the discordant answer of the brain and trunk arteries with the moderate adaptation of a regional homeostasis.
B I
BI
Gel'tser
T A
TA
Brodskaia
V N
VN
Kotel'nikov
I G
IG
Agafonova
P A
PA
Luk'ianov
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D017536:Carotid Artery, Common / Q000187:drug effects / Q000502:physiology*; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D020768:Middle Cerebral Artery / Q000187:drug effects / Q000502:physiology*; D013045:Species Specificity; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*