Diammonium hydrogen phosphate as a versatile and efficient catalyst for the one-pot synthesis of pyrano[2,3-d]pyrimidinone derivatives in aqueous media.
Diammonium hydrogen phosphate, (NH4)2HPO4, was used as a catalyst for one-pot, three-component condensation reactions consisting of aromatic aldehydes, malononitrile and barbituric/thiobarbituric acid in aqueous ethanol at room temperature. This method has the advantages of a simple operation, mild reaction conditions, high yields, by using a less toxic and low cost chemical as a catalyst.
Balalaie
Saeed
S
Peptide Chemistry Research Group, K.N. Toosi University of Technology, P.O. Box 15785-4416, Tehran, Iran. balalaie@Kntu.ac.ir
Abdolmohammadi
Shahrzad
S
Bijanzadeh
Hamid Reza
HR
Amani
Ali Mohammad
AM
D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D000431:Ethanol / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry
D010710:Phosphates; D011744:Pyrimidinones; C024788:ammonium phosphate; D000431:Ethanol