Cushing's disease complicated with thrombosis in a dog.
Thrombosis is a potential complication of hyperadrenocorticism (HAC) in dogs. An 8-year-old male Beagle diagnosed with pituitary-dependent HAC had complicated with thrombosis in the caudal vena cava and abdominal aorta, which was treated by hypophysectomy and antithrombotic therapy. After hypophysectomy, hypercortisolemia disappeared and the general condition was also significantly improved. Ultrasonography after hypophysectomy revealed that the thrombus remained in the abdominal aorta, but the thrombus in the caudal vena cava had disappeared. However 692 days after the hypophysectomy, the dog had an acute onset of dyspnea and died. Postmortem examination revealed the presence of thrombi in the abdominal aorta and the pulmonary artery. Observations from this case show that HAC dogs must be attention to thrombosis.
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan. teshima@bg8.so-net.ne.jp
Takahiro
T
Teshima
Yasushi
Y
Hara
Takahiro
T
Taoda
Hidekazu
H
Koyama
Kimimasa
K
Takahashi
Yoshinori
Y
Nezu
Yasuji
Y
Harada
Takuya
T
Yogo
Kouji
K
Nishida
Robert Y
RY
Osamura
Akira
A
Teramoto
Masahiro
M
Tagawa
D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D007016:Hypophysectomy / Q000662:veterinary; D008297:Male; D047748:Pituitary ACTH Hypersecretion / Q000150:complications / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D010900:Pituitary Diseases / Q000473:pathology / Q000601:surgery / Q000662:veterinary; D010902:Pituitary Gland / Q000473:pathology; D013927:Thrombosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
D005343:Fibrinolytic Agents