Magnetic resonance cholangiopancreatography: potential usefulness of dehydrocholic acid (DHCA) administration in the evaluation of anastomotic site.
OBJECTIVE
The aim of this study was to investigate whether exogenous dehydrocholic acid (DHCA) was useful to enhance the delineation of anastomotic site.


METHODS
DHCA is a cholagogue which produces an immediate effect by acting directly on liver cells. Its choleretic effect is strong, appearing 1 to 3 minutes after intravenous injection, reaching the maximum level in 20 to 30 minutes. Our study population comprised 9 patients. Magnetic resonance cholangiopancreatography (MRCP) was acquired before and after the administration of DHCA. Two different MRCP snap-shot techniques were applied: thick-slab two-dimensional (2D) (coronal) single-shot turbo spin echo T2-weighted sequences and multisection thin-slab, 2D (coronal) single shot turbo spin echo T2-weighted sequences with three-dimensional (3D) maximum intensity projection (MIP) post processing.


RESULTS
DHCA provided a better visualization of the anastomotic site in 7 patients (77.8%). The two patients without improvement in visualization of anastomotic site included 1 patient with liver cirrhosis secondary to portoenterostomy for congenital biliary dilatation and 1 patient, who was not eligible for the evaluation because of motion artifact caused by the difficulty of breath holding motion artifact.


CONCLUSIONS
It was suggested that administration of DHCA could enhance the delineation of the anastomotic site on MRCP images.
Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chuou-ku, Chiba City, 260-8670, Japan.
Yuji
Y
Sakai
Toshio
T
Tsuyuguchi
Seigo
S
Yukisawa
Shin
S
Tsuchiya
Harutoshi
H
Sugiyama
Kaoru
K
Miyakawa
Yoshihiro
Y
Fukuda
Masaaki
M
Ebara
Hiroi
H
Nonaka
Hiroo
H
Ikehira
Takayuki
T
Obata
Osamu
O
Yokosuka
Masaru
M
Miyazaki
D000328:Adult; D000714:Anastomosis, Surgical; D002756:Cholagogues and Choleretics; D049448:Cholangiopancreatography, Magnetic Resonance / Q000379:methods*; D002768:Choledochostomy; D003685:Dehydrocholic Acid; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D002756:Cholagogues and Choleretics; D003685:Dehydrocholic Acid