Bioactivities of gossypol, 6-methoxygossypol, and 6,6'-dimethoxygossypol.
6-Methoxygossypol and 6,6'-dimethoxygossypol were recently isolated from the root tissue of cotton plants. Together with gossypol, these natural products were investigated for a wide range of bioactivities. Antioxidant effects, the potential to prevent DNA damage, anticancer activity, and antitrypanosomal effects were studied. The 6-methoxygossypol generally exhibited equal bioactivities to the 6,6'-dimethoxygossypol, but gossypol showed greater activities than both methylated derivatives in scavenging free radicals, reducing ferric ions, and preventing UV-induced DNA damage. All three compounds inhibited the growth of cervical (SiHa), breast (MCF-7), and colon (Caco-2) cancer cells. At >/=5 ppm of test concentrations, 6,6'-dimethoxygossypol showed a stronger ability than gossypol to inhibit the growth of Trypanosoma brucei cells.
Department of Genetic and Biochemistry, Department of Food Science and Human Nutrition, and Institute for Nutraceutical Research, Clemson University, Clemson, South Carolina 29634, USA. xiw@clemson.edu
Xi
X
Wang
Thomas H
TH
Beckham
James C
JC
Morris
Feng
F
Chen
J David
JD
Gangemi
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D004249:DNA Damage / Q000187:drug effects; D003368:Gossypium / Q000737:chemistry; D006072:Gossypol / Q000494:pharmacology*; D009281:Naphthalenes / Q000494:pharmacology*; D010636:Phenols / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D014346:Trypanosoma brucei brucei / Q000187:drug effects
C511022:6-methoxy gossypol; D000970:Antineoplastic Agents; D000975:Antioxidants; D009281:Naphthalenes; D010636:Phenols; D006072:Gossypol