[The role of interferon-alpha in regulation of nervous system functions].
The review analyses contemporary data on the role of the interferon-alpha in the central nervous systems. Interferon-alpha is one of the key polyfunctional cytokines providing integrative activity of the neuro-immuno-endocrine complex. The emphasis is made on the molecular mechanisms of anti-viral, anti-proliferative and neuromodulating actions of the interferon-alpha in the brain. Mechanisms of its involvement in regulation of pain, sleep, body temperature, circadian rhythms, food consumption etc. are considered. Based on the literature and our data we hypothesized a dose-dependent action of exogenous interferon-alpha on the nervous system. We suggest that optimal schemes of chronic application of small interferon-alpha doses can be more expedient for treatment of viral or oncologic diseases than large doses causing neuropsychiatric disorders.
E V
EV
Loseva
N A
NA
Loginova
I G
IG
Akmaev
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004703:Endocrine System / Q000503:physiopathology; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D001523:Mental Disorders / Q000188:drug therapy / Q000503:physiopathology; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use; D014777:Virus Diseases / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology
D000970:Antineoplastic Agents; D016898:Interferon-alpha; D018377:Neurotransmitter Agents