Follow the monomer.
Capping proteins limit actin filament growth, but paradoxically increase actin-based cell motility. This has been attributed to funneling of actin monomers to the filament ends that remain uncapped. Using a reconstituted motility system, Akin and Mullins (2008) now demonstrate that filament capping increases Arp2/3-based nucleation and branching, rather than elevating the rate of filament elongation.
Bear
James E
JE
Lineberger Comprehensive Cancer Center and Department of Cell and Developmental Biology University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. bear@email.unc.edu
D051344:Actin Capping Proteins / Q000378:metabolism; D008841:Actin Cytoskeleton / Q000378:metabolism; D000199:Actins / Q000378:metabolism*; D002465:Cell Movement; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D008954:Models, Biological
D051344:Actin Capping Proteins; D000199:Actins; D003598:Cytoskeletal Proteins