How to introduce radioactive chlorine into a benzene ring using [*Cl]Cl-?
The aim of this study was how to introduce radioactive chlorine (*Cl) isotope into a benzene ring to afford *Cl-labeled chlorobenzene ([*Cl]1). Using tributylphenylstannyl compound (2) as a starting material, we determined two routes for introducing *Cl into the benzene ring: reaction of [*Cl]Cl(-) with 2 in the presence of chloramine-T and nucleophilic reaction of [*Cl]Cl(-) with diphenyliodonium tosylate (3). The two routes provide suitable tools to prepare [*Cl]1 without electron-abstracting group in the benzene ring.
Department of Molecular Probes, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. zhang@nirs.go.jp
Ming-Rong
MR
Zhang
Katsushi
K
Kumata
Makoto
M
Takei
Toshimitsu
T
Fukumura
Kazutoshi
K
Suzuki
D001554:Benzene / Q000737:chemistry*; D002713:Chlorine / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D011868:Radioisotopes / Q000737:chemistry*
D011868:Radioisotopes; D002713:Chlorine; D001554:Benzene