[Association of the vitamin D receptor gene BBAAtt haplotype with osteoporosis in post-menopausic women].
Osteoporosis (OP) is an important public issue affecting more than 150 millions all over the world, mainly post-menopausic women. Epidemiological studies have shown that the genetic factors could be involved in 80-90% of the bone mineral density variabiblity and therefore, related to the risk of OP manifestations. The vitamin D receptor (VRD) gene has been extensively studied, but its relationship with OP has been controversial. The aim of this investigation was to study the association of Bsm I, Apa I and Taq I VDR gene polymorphism with OP in 147 post-menopausic women; 71 with OP and 76 without the disease (control). The molecular gene analysis was performed using the polymerase chain reaction (PCR). The genotypes BB, AA, and tt were found in 56.33, 50.70 and 25.35% and in 21.05, 28.95 and 10.53% of OP patients and controls respectively. The haplotype BBAAtt was observed in 23.94% of OP patients and 5.26% of the controls. This haplotype was a risk factor for OP, since a odds ratio (OR) of 5.66 was found, while, haplotype BbaaTT was a protection factor (OR: 0.10). These findings support the association of the vitamin D receptor gene BBAAtt haplotype with OP.
Cátedra de Bioquímica Clínica, Escuela de Bioanálisis, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela. marines2122@yahoo.com
Mariana
M
Zambrano-Morales
Lisbeth
L
Borjas
Erika
E
Fernández
William
W
Zabala
Pilar
P
de Romero
Lennie
L
Pineda
Alisandra
A
Morales-Machín
D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D005260:Female; D006801:Humans; D010024:Osteoporosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D017698:Postmenopause / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*
D018167:Receptors, Calcitriol; C053864:endodeoxyribonuclease BsmI; D015252:Deoxyribonucleases, Type II Site-Specific; C038485:GGGCCC-specific type II deoxyribonucleases; C027046:TCGA-specific type II deoxyribonucleases