On the use of wavelet denoising and spike sorting techniques to process electroneurographic signals recorded using intraneural electrodes.
Among the possible interfaces with the peripheral nervous system (PNS), intraneural electrodes represent an interesting solution for their potential advantages such as the possibility of extracting spikes from electroneurographic (ENG) signals. Their use could increase the precision and the amount of information which can be detected with respect to other processing methods. In this study, in order to verify this assumption, thin-film longitudinal intrafascicular electrodes (tfLIFE) were implanted in the sciatic nerve of rabbits. Various sensory stimuli were applied to the hind limb of the animal and the elicited ENG signals were recorded using the tfLIFEs. These signals were processed to determine whether the different types of information can be decoded. Signals were wavelet denoised and spike sorted. Support vector machines were trained to use the spike waveforms found to infer the stimulus applied to the rabbit. This approach was also compared with previously used ENG-processing methods. The results indicate that the combination of wavelet denoising and spike sorting techniques can increase the amount of information extractable from ENG signals recorded with intraneural electrodes. This strategy could allow the development of more effective closed-loop neuroprostheses and hybrid bionic systems connecting the human nervous system with artificial devices.
ARTS and CRIM Labs, Scuola Superiore Sant'Anna, Pisa, Italy.
Luca
L
Citi
Jacopo
J
Carpaneto
Ken
K
Yoshida
Klaus-Peter
KP
Hoffmann
Klaus Peter
KP
Koch
Paolo
P
Dario
Silvestro
S
Micera
D000200:Action Potentials / Q000502:physiology*; D000465:Algorithms; D000818:Animals; D016477:Artifacts; D004567:Electrodes, Implanted / Q000592:standards / Q000639:trends; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods*; D005073:Evoked Potentials, Somatosensory; D005260:Female; D009431:Neural Conduction / Q000502:physiology*; D009482:Neurophysiology / Q000295:instrumentation / Q000379:methods*; D010525:Peripheral Nerves / Q000502:physiology*; D019736:Prostheses and Implants; D011817:Rabbits; D012584:Sciatic Nerve / Q000502:physiology; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D014584:User-Computer Interface