Treatment results of boron neutron capture therapy using intra-arterial administration of boron compounds for recurrent head and neck cancer.
The effect of boron neutron capture therapy (BNCT) is correlated with the density of boron in the tumour. BNCT using intra-arterial administration of boron compounds was performed for recurrent head and neck cancer. Of the five patients treated, one achieved a complete response and four achieved a partial response. There was one case of transient headache but no severe adverse effects were observed. The advantages of using an intra-arterial administration route for BNCT, which causes the selective killing of tumour cells, might offer a new option in the treatment of recurrent head and neck malignancies. These promising results require further verification and optimization of the BNCT schedule; however, dose escalation would appear to be justified because the toxicity appears to be very low.
Department of Radiation Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusaku, Nagoya 464-8681, Japan. nfuwa@aichi-cc.jp
N
N
Fuwa
M
M
Suzuki
Y
Y
Sakurai
K
K
Nagata
Y
Y
Kinashi
S
S
Masunaga
A
A
Maruhashi
Y
Y
Imahori
T
T
Kodaira
H
H
Tachibana
T
T
Nakamura
K
K
Ono
D000328:Adult; D000368:Aged; D001896:Boron Compounds / Q000008:administration & dosage*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D016022:Case-Control Studies; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D016896:Treatment Outcome
D001896:Boron Compounds