Tumour physics.
During the cell division dynamic processes take place, the origin of which are to find in the physical characteristics of cell components. The most important characteristics are the electrical charge and the energy of the moving base components in a viscous cytoplasm. The interactions between the components lead as well known, to the emergence of hydrogen bonds between two DNA strands. The computations show that the strength of these bindings depends on three factors: first it is dependent on the length of a monotonous sequence, second it is dependent on the viscosity of the cytoplasm, and third it is dependent on the replication speed. In the study in detail is stated, how it affects the effectiveness of the DNA repair mechanism, mutation susceptibility, and thus also affects the cancer susceptibility.
Drechsel
Willy Dieter
WD
redidrechsel@tiscali.de.
D000818:Animals; D001483:Base Sequence / Q000502:physiology; D001692:Biological Transport / Q000235:genetics; D055592:Biophysical Phenomena; D001703:Biophysics; D002455:Cell Division / Q000235:genetics; D003593:Cytoplasm / Q000737:chemistry / Q000378:metabolism; D018736:DNA Adducts / Q000737:chemistry / Q000378:metabolism; D004249:DNA Damage / Q000502:physiology; D004260:DNA Repair / Q000502:physiology; D004261:DNA Replication / Q000502:physiology; D019281:Dimerization; D020022:Genetic Predisposition to Disease; D006801:Humans; D006860:Hydrogen Bonding; D007700:Kinetics; D008954:Models, Biological; D008956:Models, Chemical; D008970:Molecular Weight; D009154:Mutation; D009369:Neoplasms / Q000737:chemistry* / Q000235:genetics*; D055585:Physical Phenomena; D010825:Physics; D014783:Viscosity
D018736:DNA Adducts