Endogenous mycotic endophthalmitis in an immunocompetent patient.
Acute and invasive fungal infections are usually seen in immunocompromised and debilitated patients. We report a young immunocompetent 28-year-old Indian male who presented with unilateral endogenous endophthalmitis in the left eye and was managed with pars plana vitreous surgery. The polymerase chain reaction from the vitrectomy specimen tested positive for the fungal genome while the cytology examination identified aseptate hyphae with wide-angle branching, most likely suggesting Zygomycosis. A detailed systemic evaluation failed to reveal any systemic focus or predisposing factor for fungal infection. The patient had received intravenous dextrose infusions while undergoing a surgical procedure for post-traumatic hydrocele elsewhere a week prior to this episode. The patient was successfully managed with pars plana vitreous surgery along with intravitreal Amphotericin-B and oral Voriconazole.
Gupta
Pawan
P
Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India.
Sachdev
Nishant
N
Kaur
Jasleen
J
Dey
Pranab
P
Gupta
Vishali
V
Gupta
Amod
A
D000284:Administration, Oral; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000150:complications / Q000175:diagnosis / Q000276:immunology* / Q000382:microbiology* / Q000601:surgery; D015821:Eye Infections, Fungal / Q000175:diagnosis; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007121:Immunocompetence; D007267:Injections; D008297:Male; D011743:Pyrimidines / Q000008:administration & dosage; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage; D014786:Vision Disorders / Q000209:etiology; D014821:Vitrectomy / Q000379:methods; D014822:Vitreous Body / Q000382:microbiology; D065819:Voriconazole; D020096:Zygomycosis / Q000175:diagnosis
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole