Convenient synthesis of ethyl 4-aryl-6-(trifluoromethyl)-2-oxo-2H-pyran-3-carboxylates and 4-aryl-6-(trifluoromethyl)-2H-pyran-2-ones: novel highly reactive CF3-containing building blocks.
An expedient synthesis of a series of 2-pyrones, bearing a CF 3 group at the 6-position and aryl group at position 4, from readily available aryl-4,4,4-trifluorobutane-1,3-diones, PCl 5, and sodium diethyl malonate is described.
Department of Chemistry, Ural State University, 620083 Ekaterinburg, Russia, and Institute of Inorganic & Physical Chemistry, University of Bremen, 28334 Bremen, Germany. boris.usachev@mail.ru
Boris I
BI
Usachev
Dmitrii L
DL
Obydennov
Gerd-Volker
GV
Röschenthaler
Vyacheslav Ya
VY
Sosnovskikh
D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D017611:Fluorine Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry
D002264:Carboxylic Acids; D017611:Fluorine Compounds; D011714:Pyrans; D010100:Oxygen