Strong association of de novo copy number mutations with sporadic schizophrenia.
Schizophrenia is an etiologically heterogeneous psychiatric disease, which exists in familial and nonfamilial (sporadic) forms. Here, we examine the possibility that rare de novo copy number (CN) mutations with relatively high penetrance contribute to the genetic component of schizophrenia. We carried out a whole-genome scan and implemented a number of steps for finding and confirming CN mutations. Confirmed de novo mutations were significantly associated with schizophrenia (P = 0.00078) and were collectively approximately 8 times more frequent in sporadic (but not familial) cases with schizophrenia than in unaffected controls. In comparison, rare inherited CN mutations were only modestly enriched in sporadic cases. Our results suggest that rare de novo germline mutations contribute to schizophrenia vulnerability in sporadic cases and that rare genetic lesions at many different loci can account, at least in part, for the genetic heterogeneity of this disease.
Xu
Bin
B
Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA.
Roos
J Louw
JL
Levy
Shawn
S
van Rensburg
E J
EJ
Gogos
Joseph A
JA
Karayiorgou
Maria
M
D000465:Algorithms; D002874:Chromosome Mapping / Q000379:methods; D002877:Chromosomes, Human; D005190:Family; D005260:Female; D018628:Gene Dosage; D005787:Gene Frequency; D008040:Genetic Linkage; D005820:Genetic Testing; D005828:Genetics, Population; D005838:Genotype; D018095:Germ-Line Mutation; D006801:Humans; D040582:Inheritance Patterns; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D012559:Schizophrenia / Q000235:genetics*