Resistance exercise biology: manipulation of resistance exercise programme variables determines the responses of cellular and molecular signalling pathways.
Recent advances in molecular biology have elucidated some of the mechanisms that regulate skeletal muscle growth. Logically, muscle physiologists have applied these innovations to the study of resistance exercise (RE), as RE represents the most potent natural stimulus for growth in adult skeletal muscle. However, as this molecular-based line of research progresses to investigations in humans, scientists must appreciate the fundamental principles of RE to effectively design such experiments. Therefore, we present herein an updated paradigm of RE biology that integrates fundamental RE principles with the current knowledge of muscle cellular and molecular signalling. RE invokes a sequential cascade consisting of: (i) muscle activation; (ii) signalling events arising from mechanical deformation of muscle fibres, hormones, and immune/inflammatory responses; (iii) protein synthesis due to increased transcription and translation; and (iv) muscle fibre hypertrophy. In this paradigm, RE is considered an 'upstream' signal that determines specific downstream events. Therefore, manipulation of the acute RE programme variables (i.e. exercise choice, load, volume, rest period lengths, and exercise order) alters the unique 'fingerprint' of the RE stimulus and subsequently modifies the downstream cellular and molecular responses.
Spiering
Barry A
BA
Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, Connecticut 06269, USA.
Kraemer
William J
WJ
Anderson
Jeffrey M
JM
Armstrong
Lawrence E
LE
Nindl
Bradley C
BC
Volek
Jeff S
JS
Maresh
Carl M
CM
D000249:Adenosine Monophosphate; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D036341:Intercellular Signaling Peptides and Proteins; D009119:Muscle Contraction / Q000502:physiology*; D018485:Muscle Fibers, Skeletal; D018482:Muscle, Skeletal / Q000254:growth & development / Q000502:physiology*; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D020123:Sirolimus; D014891:Weight Lifting / Q000502:physiology*
D036341:Intercellular Signaling Peptides and Proteins; D000249:Adenosine Monophosphate; D007334:Insulin-Like Growth Factor I; D051057:Proto-Oncogene Proteins c-akt; D020123:Sirolimus