Genetics of melanoma predisposition.
Over the past 10 years, our understanding of melanoma at the molecular level has blossomed with the advent of genomic technologies. The enormous enthusiasm for the Human Genome Project is slowly being replaced by an even greater excitement for the unravelling of disease genomes, including melanoma. In this review, we will consider some of the clinical implications of these genetic findings for both diagnostics and therapeutics.
Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.
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J
Lin
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TL
Hocker
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Singh
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Tsao
D051358:Cyclin-Dependent Kinase 4 / Q000235:genetics; D051361:Cyclin-Dependent Kinase 6 / Q000235:genetics; D019942:Genes, p16; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control; D010375:Pedigree; D012878:Skin Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control
C495900:CDK4 protein, human; C495911:CDK6 protein, human; D051358:Cyclin-Dependent Kinase 4; D051361:Cyclin-Dependent Kinase 6