The development of metachronous prostate cancer and chronic myeloid leukemia in a patient with metastatic rectal cancer.
We report herein an unusual case of metachronous triple cancers (rectum, prostate and Philadelphia(+) [Ph(+)] chronic myeloid leukemia [CML]). A metastatic rectal cancer was diagnosed in a 76-year-old male patient, who was treated with transanal tumor resection and chemotherapy. Thirty months from the initial rectal cancer diagnosis, prostate cancer was diagnosed and the patient was administered maximal androgen blockade and received palliative radiotherapy to the lumbar spine because of painful bone metastases. Thirty months after the diagnosis of rectal cancer and 12 months after the diagnosis of prostate cancer the patient developed Ph(+) CML and imatinib treatment was started. After one-year period in remission, CML evolved into accelerated phase and the patient died of intracranial hemorrhage.
Dokuz Eylul University, Institute of Oncology, Izmir, Turkey.
I
I
Oztop
A
A
Yaren
M
M
Demirpence
I
I
Alacacioglu
B
B
Tuna
O
O
Piskin
U
U
Yilmaz
D000368:Aged; D001549:Benzamides; D001752:Blast Crisis; D001859:Bone Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary; D017809:Fatal Outcome; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D010677:Philadelphia Chromosome; D010879:Piperazines / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011743:Pyrimidines / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*
D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D011505:Protein-Tyrosine Kinases