Computational tools for the analysis of rearrangements in mammalian genomes.
The chromosomes of mammalian genomes exhibit reasonably high levels of similarity that can be used to study small-scale sequence variations. A different approach is to study the evolutionary history of rearrangements in entire genomes based on the analysis of gene or segment orders. This chapter describes three computational tools (GRIMM-Synteny, GRIMM, and MGR) that can be used separately or in succession to contrast different organisms at the genome-level to exploit large-scale rearrangements as a phylogenetic character.
Genome Institute of Singapore, Singapore, Republic of Singapore.
Guillaume
G
Bourque
Glenn
G
Tesler
D000818:Animals; D033481:Chromosomes, Mammalian / Q000235:genetics*; D019295:Computational Biology / Q000379:methods*; D015321:Gene Rearrangement; D016678:Genome; D008322:Mammals / Q000235:genetics*; D010802:Phylogeny; D012984:Software