Nasal lavage with mupirocin for the treatment of surgically recalcitrant chronic rhinosinusitis.
OBJECTIVE
To examine the efficacy and tolerability of topical mupirocin for the management of surgically recalcitrant chronic rhinosinusitis (CRS) associated with Staphylococcus aureus infection.


METHODS
Prospective open-label pilot study.


METHODS
Patients with surgically recalcitrant CRS who had positive nasendoscopically guided cultures for Staphylococcus aureus were treated with twice daily nasal lavages containing 0.05% Mupirocin and lactated ringers salts. The duration of treatment was 3 weeks. Patients were assessed before and after treatment in terms of nasendoscopic findings, microbiology results, and Sinonasal Outcome Test (SNOT-20) and visual analogue scale questionnaires.


RESULTS
Fifteen of 16 patients had improved nasendoscopic findings after treatment. Twelve of 16 patients noted overall symptom improvement. Fifteen of 16 patients had negative swab results for Staphylococcus aureus after treatment. Only minimal adverse effects were experienced.


CONCLUSIONS
Nasal Lavage with 0.05% Mupirocin may represent an effective and well tolerated alternative treatment for postsurgical recalcitrant CRS.
Uren
Brent
B
Department of Surgery-Otolaryngology, University of Adelaide, Woodville, Australia.
Psaltis
Alkis
A
Wormald
Peter-John
PJ
D000281:Administration, Intranasal; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016712:Mupirocin / Q000008:administration & dosage*; D013517:Otorhinolaryngologic Surgical Procedures / Q000009:adverse effects*; D010865:Pilot Projects; D011446:Prospective Studies; D012220:Rhinitis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D012852:Sinusitis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D013203:Staphylococcal Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013530:Surgical Wound Infection / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D007507:Therapeutic Irrigation; D016896:Treatment Outcome
D016712:Mupirocin