Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive impairments in memory and cognition. Extracellular accumulation of soluble high-molecular-weight (HMW) Abeta oligomers has been proposed to be largely responsible for AD dementia and memory deficits in the Tg2576 mice, a model of AD. In this study, we found that a naturally derived grape seed polyphenolic extract can significantly inhibit amyloid beta-protein aggregation into high-molecular-weight oligomers in vitro. When orally administered to Tg2576 mice, this polyphenolic preparation significantly attenuates AD-type cognitive deterioration coincidentally with reduced HMW soluble oligomeric Abeta in the brain. Our study suggests that grape seed-derived polyphenolics may be useful agents to prevent or treat AD.
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.
Jun
J
Wang
Lap
L
Ho
Wei
W
Zhao
Kenjiro
K
Ono
Clark
C
Rosensweig
Linghong
L
Chen
Nelson
N
Humala
David B
DB
Teplow
Giulio M
GM
Pasinetti
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D003072:Cognition Disorders / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D010636:Phenols / Q000302:isolation & purification / Q000627:therapeutic use*; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D059808:Polyphenols; D027843:Vitis
D016229:Amyloid beta-Peptides; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols