Choriocarcinoma in an AIDS patient--relapsing but not fatal.
Choriocarcinoma is associated with high mortality in immunocompromised patients, in contrast to a good prognosis in immunocompetent individuals. Respiratory failure due to metatstatic choriocarcinoma is associated with high mortality in any patient. We report a case of a woman with AIDS that survived metastatic choriocarcinoma and respiratory failure. We also observed that in contrast to some in vitro studies, the markedly elevated levels of beta-subunit of human chorionic gonadotropin in this patient did not have any apparent inhibitory effect on viral replication.
Department of Medicine, Baystate Medical Center, Tufts University School of Medicine, 759 Chestnut Street - S2570, Springfield, MA 01199, USA. shaharch@yahoo.com
Archan M
AM
Shah
Mark
M
Tidswell
Michel
M
Prefontaine
Daniel J
DJ
Skiest
Liron
L
Pantanowitz
D017088:AIDS-Related Opportunistic Infections / Q000209:etiology / Q000517:prevention & control; D000328:Adult; D002822:Choriocarcinoma / Q000209:etiology / Q000517:prevention & control; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D012008:Recurrence; D012131:Respiratory Insufficiency; D014594:Uterine Neoplasms / Q000209:etiology / Q000517:prevention & control; D019562:Viral Load
D018997:Chorionic Gonadotropin, beta Subunit, Human