Directions in QSAR modeling for regulatory uses in OECD member countries, EU and in Russia.
The aim of this article is to show the main aspects of quantitative structure activity relationship (QSAR) modeling for regulatory purposes. We try to answer the question; what makes QSAR models suitable for regulatory uses. The article focuses on directions in QSAR modeling in European Union (EU) and Russia. Difficulties in validation models have been discussed.
Fjodorova
Natalja
N
National Institute of Chemistry, Ljubljana, Slovenia. natalja.fjodorova@ki.si
Novich
Marjana
M
Vrachko
Marjan
M
Smirnov
Vjacheslav
V
Kharchevnikova
Nina
N
Zholdakova
Zoya
Z
Novikov
Sergei
S
Skvortsova
Natalja
N
Filimonov
Dmitrii
D
Poroikov
Vladimir
V
Benfenati
Emilio
E
D032761:Animal Experimentation; D023401:Animal Use Alternatives; D000818:Animals; D005060:Europe; D015386:Hazardous Substances / Q000145:classification / Q000633:toxicity*; D006801:Humans; D008954:Models, Biological; D011237:Predictive Value of Tests; D011356:Product Labeling; D011640:Public Policy; D021281:Quantitative Structure-Activity Relationship; D018570:Risk Assessment; D012426:Russia; D018675:Toxicity Tests
D015386:Hazardous Substances