Molecular characterization of ofloxacin-resistant Mycobacterium tuberculosis strains from Russia.
In this work, we studied the variation in the gyrA and gyrB genes in ofloxacin- and multidrug-resistant Mycobacterium tuberculosis strains circulating in northwest Russia. Comparison with spoligotyping data suggested that similar to the spread of multidrug-resistant tuberculosis, the spread of fluoroquinolone-resistant tuberculosis in Russia may be due, at least partly, to the prevalence of the Beijing genotype in a local population of M. tuberculosis.
Laboratory of Molecular Microbiology, St. Petersburg Pasteur Institute, 197101 St. Petersburg, Russia. igormokrousov@yahoo.com
Igor
I
Mokrousov
Tatiana
T
Otten
Olga
O
Manicheva
Yulia
Y
Potapova
Boris
B
Vishnevsky
Olga
O
Narvskaya
Nalin
N
Rastogi
D000995:Antitubercular Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D027081:DNA Gyrase / Q000235:genetics / Q000378:metabolism; D005838:Genotype; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D015242:Ofloxacin / Q000494:pharmacology*; D012426:Russia; D018088:Tuberculosis, Multidrug-Resistant / Q000235:genetics*
D000995:Antitubercular Agents; D001426:Bacterial Proteins; D015242:Ofloxacin; D027081:DNA Gyrase