Ethanolic extract of Artemisia aucheri induces regression of aorta wall fatty streaks in hypercholesterolemic rabbits.
Artemisia aucheri is a native-growing plant which is widely used in Iranian traditional medicine. This study was designed to evaluate the effects of A. aucheri on regression of atherosclerosis in hypercholesterolemic rabbits. Twenty five rabbits were randomly divided into five groups of five each and treated 3-months as follows: 1: normal diet, 2: hypercholesterolemic diet (HCD), 3 and 4: HCD for 60 days and then normal diet and normal diet + A. aucheri (100 mg x kg(-1) x day(-1)) respectively for an additional 30 days (regression period). In the regression period dietary use of A. aucheri in group 4 significantly decreased total cholesterol, triglyceride and LDL-cholesterol, while HDL-cholesterol was significantly increased. The atherosclerotic area was significantly decreased in this group. Animals, which received only normal diet in the regression period showed no regression but rather progression of atherosclerosis. These findings suggest that A. aucheri may cause regression of atherosclerotic lesions.
Asgary
S
S
Isfahan Cardiovascular research center (WHO-Collaborating centre in EMR), Isfahan University of Medical Sciences, Isfahan, Iran. s_asgari@crc.mui.ac.ir
Dinani
N Jafari
NJ
Madani
H
H
Mahzouni
P
P
D000818:Animals; D001011:Aorta / Q000473:pathology; D019306:Artemisia / Q000737:chemistry*; D050197:Atherosclerosis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D000431:Ethanol; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D009206:Myocardium / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology; D011817:Rabbits; D012997:Solvents; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D010936:Plant Extracts; D012997:Solvents; D014280:Triglycerides; D000431:Ethanol; D002784:Cholesterol