Three new glycolipids with cytolytic activity from cultured marine dinoflagellate Heterocapsa circularisquama.
A monogalactosyl monoacylglycerol 1 and two digalactosyl monoacylglycerols 2 and 3 were isolated from a cultured marine dinoflagellate Heterocapsa circularisquama along with known (2S)-1-O-6,9,12,15-octadecatetraenoyl-3-O-beta-D-galactopyranosyl]-sn-glycerol (4). On the basis of spectral analysis, the glycolipid 1 was characterised as (2S)-1-O-3,6,9,12,15-octadecapentaenoyl-3-O-beta-D-galactopyranosyl]-sn-glycerol. The glycolipids 2 and 3 were characterised as (2S)-1-O-3,6,9,12,15-octadecapentaenoyl-3-O-[alpha-D-galactopyranosyl-(1''' --> 6'')-O-beta-D-galactopyranosyl]-sn-glycerol and (2S)-1-O-6,9,12,15-octadecatetraenoyl-3-O-[alpha-D-galactopyranosyl-(1''' --> 6'')-O-beta-D-galactopyranosyl]-sn-glycerol, respectively. The isolated monoacylglycerols 1-4 showed cytolytic activity towards heart and gill cells of oyster.
Department of Chemistry, Graduate School of Science, Kagamiyama, Higashi-Hiroshima 739-8526, Japan. yhiraga@sci.hiroshima-u.ac.jp
Yoshikazu
Y
Hiraga
Tatsuya
T
Shikano
Triana
T
Widianti
Katsuo
K
Ohkata
D000818:Animals; D003603:Cytotoxins / Q000302:isolation & purification* / Q000633:toxicity; D004141:Dinoflagellida / Q000737:chemistry*; D006017:Glycolipids / Q000737:chemistry / Q000302:isolation & purification*; D010125:Ostreidae
D003603:Cytotoxins; D006017:Glycolipids