[Hypothesis: phagocytosis of aberrant cells protects long life span vertebrate species against tumors].
Probable mechanisms of resistance to carcinogenic impacts and spontaneous tumours of long life span vertebrate species have been discussed. It has been suggested that this compatible with long life span mechanism is likely phagocyte elimination with involving DNA-protenkinase-dependent, wt p53 or/and wt p53-dependent signaling pathways also ligands for "Scavenger receptor" and "Toll-like receptors". The approaches to the experimental evidence of this hypothesis have been produced.
Manskikh
V N
VN
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002869:Chromosome Aberrations; D008136:Longevity / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D010586:Phagocytes / Q000502:physiology*; D010587:Phagocytosis / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D014714:Vertebrates / Q000235:genetics / Q000502:physiology*
D016159:Tumor Suppressor Protein p53