Acute effects of radioiodine therapy on the voice and larynx of Basedow-Graves patients.
Graves's disease is the most common cause of hyperthyroidism. There are three current therapeutic options: anti-thyroid medication, surgery, and radioactive iodine (I 131). There are few data in the literature regarding the effects of radioiodine therapy on the larynx and voice. The aim and the


OBJECTIVE
os this study was: to assess the effect of radioiodine therapy on the voice of Basedow-Graves patients.


METHODS
A prospective study was done. Following the diagnosis of Grave's disease, patients underwent investigation of their voice, measurement of maximum phonatory time (/a/) and the s/z ratio, fundamental frequency analysis (Praat software), laringoscopy and (perceptive-auditory) analysis in three different conditions: pre-treatment, 4 days, and 20 days post-radioiodine therapy. Conditions are based on the inflammatory pattern of thyroid tissue (Jones et al. 1999).


RESULTS
No statistically significant differences were found in voice characteristics in these three conditions.


CONCLUSIONS
Radioiodine therapy does not affect voice quality.
Medical Science School, São Paulo Santa Casa (FCMSCSP), Brazil.
Roberta Werlang
RW
Isolan-Cury
Osmar
O
Monte
Adriano Namo
AN
Cury
Marta Assumpção de
MA
Andrada E Silva
André
A
Duprat
Marília
M
Marone
Renata de
Rd
Almeida
Alexandre
A
Iglesias
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001307:Auditory Perception / Q000502:physiology; D015331:Cohort Studies; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000503:physiopathology / Q000532:radiotherapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007828:Laryngoscopy; D007830:Larynx / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D010699:Phonation / Q000502:physiology; D011446:Prospective Studies; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D014831:Voice / Q000528:radiation effects*
D007457:Iodine Radioisotopes; D013972:Thyrotropin; D013974:Thyroxine