Pseudoxanthoma elasticum in a patient with sickle cell disease: case report.
An 18 year female sickler (HbSS) presented with repeated history of epistaxis and bleeding gums. Features consistent with pseudoxanthoma elasticum were observed, such as hyper-extensile redundant skin folds in the neck, axilla, inguinal areas and abdomen. The skin biopsy showed swollen, clumped and fragmented elastic fibres and calcium deposits in the deep and mid reticular dermis, consistent with pseudoxanthoma elasticum. This is a well recognised complication of sickle cell disease which has not been described in Kenya.
Adam
A M
AM
Department of Clinical Medicine and Therapeutics, College of Health Sciences, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya.
Maritim
M C
MC
D000082:Acetaminophen / Q000627:therapeutic use; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000755:Anemia, Sickle Cell / Q000150:complications*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002443:Ceftriaxone / Q000627:therapeutic use; D004844:Epistaxis; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D006801:Humans; D011561:Pseudoxanthoma Elasticum / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014803:Vitamin B Complex / Q000627:therapeutic use
D018712:Analgesics, Non-Narcotic; D000900:Anti-Bacterial Agents; D014803:Vitamin B Complex; D000082:Acetaminophen; D002443:Ceftriaxone; D005492:Folic Acid