Use of nanoparticles for cerebral cancer.
Nanoparticles made of poly(butyl cyanoacrylate) (PBCA) or poly(lactic-co-glycolic acid) (PLGA) coated with polysorbate 80 or poloxamer 188 enable the transport of cytostatics such as doxorubicin across the blood-brain barrier (BBB). Following intravenous injection to rats bearing intracranially the very aggressive glioblastoma 101/8 these particles loaded with doxorubicin significantly increased the survival times and led to a complete tumor remission in 20-40% of the animals. Moreover, these particles considerably reduced the dose-limiting cardiotoxicity and also the testicular toxicity of this drug. The drug transport across the BBB by nanoparticles appears to be due to a receptor-mediated interaction with the brain capillary endothelial cells, which is facilitated by certain plasma apolipoproteins adsorbed by nanoparticles in the blood.
Institute for Pharmaceutical Technology, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany. Kreuter@em.uni-frankfurt.de
Jörg
J
Kreuter
Svetlana
S
Gelperina
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism; D001932:Brain Neoplasms / Q000175:diagnosis / Q000628:therapy; D002196:Capillaries / Q000187:drug effects / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000009:adverse effects; D004337:Drug Carriers; D004659:Enbucrilate; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D005079:Excipients; D006801:Humans; D019344:Lactic Acid; D053758:Nanoparticles; D020442:Poloxamer; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011136:Polysorbates; D051381:Rats; D013501:Surface-Active Agents; D016019:Survival Analysis
D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D005079:Excipients; D011136:Polysorbates; D013501:Surface-Active Agents; D020442:Poloxamer; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D004317:Doxorubicin; D004659:Enbucrilate