Solid-phase synthesis of a lysine-capped bis-dendron with remarkable DNA delivery abilities.
Solid-phase synthesis of a generation 3.0 polyamidourea 1-->3 C-branched bis-dendron followed by capping of the peripheral amino groups with L-lysine gave an efficient transfection reagent.
School of Chemistry, King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, UK.
Siew-Eng
SE
How
Asier
A
Unciti-Broceta
Rosario M
RM
Sánchez-Martín
Mark
M
Bradley
D002460:Cell Line; D004247:DNA / Q000737:chemistry / Q000235:genetics*; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D004586:Electrophoresis; D018014:Gene Transfer Techniques / Q000295:instrumentation*; D006801:Humans; D008239:Lysine / Q000737:chemistry*
D050091:Dendrimers; D004247:DNA; D008239:Lysine