Cancer stem cells in breast: current opinion and future challenges.
There is increasing evidence for the cancer stem cell hypothesis, which holds that cancers are driven by a cellular subcomponent that has stem cell properties, that is, self-renewal, tumorigenicity and multilineage differentiation capacity. The cancer stem cell hypothesis modifies our conceptual approach of oncogenesis and shall have implications in breast cancer prevention, detection and treatment, especially in metastatic breast cancer for which no curative treatment exists. Given the specific stem cell features, novel therapeutic pathways can be targeted. Following this approach, new molecules are currently in development. Focusing on the cross-talk between stem cells and their microenvironment is also a promising way to explore how to better target cancer stem cells and be curative.
Département d'Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille, Marseille, France. jauffrete@marseille.fnclcc.fr
Emmanuelle
E
Charafe-Jauffret
Florence
F
Monville
Christophe
C
Ginestier
Gabriela
G
Dontu
Daniel
D
Birnbaum
Max S
MS
Wicha
D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology*; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism
D051880:Receptors, Notch; D051153:Wnt Proteins