Regulation of TNFR1 and CD95 signalling by receptor compartmentalization.
The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as FAS and APO-1) transduce signals that promote cell death by apoptosis. However, these receptors are also capable of inducing anti-apoptotic signals through the activation of the transcription factor nuclear factor-kappaB (NF-kappaB) or through activation of the proliferative mitogen-activated protein kinase (MAPK) cascade. Recent findings reveal a role for receptor internalization and endosomal trafficking in selectively transmitting the signals that lead either to apoptosis or to the survival of the cell.
Institute of Immunology, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany. schuetze@immunologie.uni-kiel.de
Stefan
S
Schütze
Vladimir
V
Tchikov
Wulf
W
Schneider-Brachert
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002451:Cell Compartmentation / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D021381:Protein Transport / Q000502:physiology; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D019014:fas Receptor / Q000378:metabolism* / Q000502:physiology
D047888:Receptors, Tumor Necrosis Factor, Type I; D019014:fas Receptor