Tumor promoting or tumor suppressing of NF-kappa B, a matter of cell context dependency.
Nuclear factor-kappa B (NF-kappa B) and its activating signaling pathways are critical regulators for cell lineage development, growth, differentiation, apoptosis, and tumorigenic transformation. As one of the most important transcription factors, NF-kappa B has been implicated in the transcriptional upregulation of a number of cytokines, adhesion molecules, growth factors, oncogenes, antiapoptotic proteins, some proapoptotic factors, and even certain viral genes. The role of NF-kappa B on tumor promoting has been well-documented in the past two decades. However, during the past few years, a considerable number of studies suggested that NF-kappa B and its activating signaling molecules may act as tumor suppressors under some circumstances. Thus, it is highly possible that tumor promoting or tumor suppressing of NF-kappa B signaling is determined by the type of cells, stimuli, simultaneous or asynchronous intracellular signals, and other cellular contexts.
Chen
Fei
F
Pathology and Physiology Research Branch, The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. LFD3@cdc.gov
Beezhold
Kevin
K
Castranova
Vince
V
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000276:immunology*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D016166:Free Radical Scavengers / Q000276:immunology; D019337:Hematologic Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology; D016328:NF-kappa B / Q000235:genetics* / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000235:genetics / Q000276:immunology / Q000473:pathology; D018384:Oxidative Stress / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*; D025521:Tumor Suppressor Proteins / Q000276:immunology*
D016166:Free Radical Scavengers; D016328:NF-kappa B; D025521:Tumor Suppressor Proteins