Histopathologic and molecular aspects of CD56+ natural killer/ T-cell lymphoma of the testis.
Primary nasal-type natural killer/T-cell lymphoma of the testis is a rare malignancy. Although dissemination to the testis from other sites occurs somewhat more frequently than a primary presentation, even secondary testicular involvement is uncommon. In this article, the authors report on the comprehensive histopathologic, immunohistochemical, and molecular analysis of a case of primary testicular nasal-type natural killer/T-cell lymphoma, and review the features of 16 previously reported patients. The investigation carried out in this study indicates that the testicular nasal-type natural killer/T-cell lymphomas occur at a younger age than their B-cell counterparts, express cytoplasmic CD3 and surface CD56, and consistently show an infection by Epstein-Barr virus. These tumors have variable expression of T-cell antigens other than cytoplasmic CD3 and may show monoclonal rearrangement of T-cell receptor genes. Testicular natural killer/T-cell lymphomas of nasal type invariably follow an aggressive clinical course.
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520-8035, USA. deborah.ornstein@yale.edu
Deborah L
DL
Ornstein
Carlo B
CB
Bifulco
Demetrios T
DT
Braddock
John G
JG
Howe
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007694:Killer Cells, Natural / Q000737:chemistry / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000821:virology; D008297:Male; D009919:Orchiectomy; D012367:RNA, Viral / Q000032:analysis; D013736:Testicular Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000821:virology; D014750:Vincristine / Q000627:therapeutic use
D014408:Biomarkers, Tumor; D019002:CD56 Antigen; C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral; D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin; D003520:Cyclophosphamide