Role of Nox2 in elimination of microorganisms.
NADPH oxidase of the phagocytic cells (Nox2) transfers electrons from cytosolic NADPH to molecular oxygen in the extracellular or intraphagosomal space. The produced superoxide anion (O*2) provides the source for formation of all toxic oxygen derivatives, but continuous O*2 generation depends on adequate charge compensation. The vital role of Nox2 in efficient elimination of microorganisms is clearly indicated by human pathology as insufficient activity of the enzyme results in severe, recurrent bacterial infections, the typical symptoms of chronic granulomatous disease. The goals of this contribution are to provide critical review of the Nox2-dependent cellular processes that potentially contribute to bacterial killing and degradation and to indicate possible targets of pharmacological interventions.
Laboratory of Host Defenses, Molecular Defenses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Balázs
B
Rada
Csilla
C
Hably
András
A
Meczner
Csaba
C
Timár
Gergely
G
Lakatos
Péter
P
Enyedi
Erzsébet
E
Ligeti
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000502:physiology*; D006801:Humans; D019255:NADPH Oxidases / Q000276:immunology* / Q000378:metabolism*; D010586:Phagocytes / Q000201:enzymology / Q000276:immunology*; D013481:Superoxides / Q000276:immunology
D013481:Superoxides; D019255:NADPH Oxidases