[Investigation of antihypoxic properties of short peptides].
The data presented suggest that short regulatory peptides (vilon, epitalon, vesugen and pinealon) have manifested the antihypoxic properties in the model of hypobaric hypoxia. Pinealon (Glu-Asp-Arg) has the most pronounced effect among them. The capability of pinealon to increase the neuronal resistance to hypoxic stress in experiments with prenatal hypoxia has a complex nature. It is based not so much on the inhibition of ROS increase in cells in response to stress as on stimulation of internal antioxidative enzyme system and possibly limiting the excitotoxic effect of N-methyl-D-aspartate.
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D000222:Adaptation, Physiological / Q000187:drug effects; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development / Q000473:pathology; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D000860:Hypoxia / Q000150:complications / Q000503:physiopathology / Q000517:prevention & control; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development / Q000473:pathology; D008297:Male; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D012143:Respiratory Physiological Phenomena / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism
D018696:Neuroprotective Agents; D009842:Oligopeptides; C521328:arginyl-glutamyl-arginine; C570174:pinealon; D000255:Adenosine Triphosphate; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase