Prevalence of insulin resistance and determination of risk factors for glucose intolerance in polycystic ovary syndrome: a cross-sectional study of Chinese infertility patients.
OBJECTIVE
To determine the prevalence of abnormalities in glucose metabolism in patients with polycystic ovary syndrome (PCOS) and control infertility patients in Taiwan, and to determine the predictive risk factors for PCOS.


METHODS
Cross-sectional study.


METHODS
Infertility Center, Taiwan Adventist Hospital.


METHODS
Three hundred fifty-six patients with PCOS and 974 control infertility patients.


METHODS
None.


METHODS
Hormone assay and 75-g oral glucose tolerance test.


RESULTS
Patients with PCOS were younger (32.7 vs. 35.3 years) with a higher body mass index (BMI) (22.4 vs. 20.6 kg/m(2)) than controls. Even after BMI adjustment, patients with PCOS still had significantly higher fasting glucose (97.2 vs. 94.4 mg/dL), fasting insulin (5.6 vs. 4.1 microIU/mL), 2-hour glucose (108.1 vs. 96.0 mg/dL), and 2-hour insulin levels (38.0 vs. 27.0 microIU/mL), and higher homeostasis model assessment of insulin resistance (HOMA-IR) values (1.3 vs. 1.0) than control patients. The prevalence of impaired glucose tolerance and diabetes mellitus in patients with PCOS was 7.6% and 3.1%, respectively, compared with 2.9% and 0.2% in the control group, respectively. Only fasting glucose and insulin, 2-hour insulin, HOMA-IR, age, androstenedione, and status (PCOS vs. control) had a significant impact on 2-hour glucose level. However, BMI and waist/hip ratio did not show a significant impact on 2-hour glucose level.


CONCLUSIONS
Chinese women with PCOS are at increased risk for insulin resistance and glucose intolerance compared with controls. Body mass index failed to show significant impact on 2-hour glucose levels in our infertility patients.
Wei
Hsiao-Jui
HJ
Graduate Institute of Medical Science, Taipei Medical University, Taipei, Taiwan.
Young
Robert
R
Kuo
I-Li
IL
Liaw
Chian-Mey
CM
Chiang
Han-Sun
HS
Yeh
Ching-Ying
CY
D000328:Adult; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism*; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D015995:Prevalence; D012307:Risk Factors