Interactions between infections and immune-inflammatory cells in type 1 diabetes mellitus and inflammatory bowel diseases: evidences from animal models.
Type 1 diabetes mellitus (T1D) and inflammatory bowel diseases (IBD) are multifactorial disorders of autoimmune origin. Several microbial agents have been reported to be associated with the development of type 1 diabetes and inflammatory bowel diseases in animal models by different mechanisms. These models which resemble the phenotype of the human disease they mimic, can be very useful to identify important pathogenetic mechanisms, as well as therapeutical targets to treat the disease. This review is focused on the immune inflammatory pathways which are considered to be associated with the pathogenesis T1D and IBD in transgenic mice.
Claesson
M H
MH
Department of International Health, Immunology and Microbiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Nicoletti
F
F
Stosic-Grujicic
S
S
Doria
A
A
Zampieri
S
S
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology / Q000382:microbiology / Q000821:virology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000382:microbiology / Q000821:virology; D004195:Disease Models, Animal; D007239:Infections / Q000150:complications* / Q000276:immunology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000382:microbiology / Q000821:virology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000382:microbiology / Q000821:virology