D-allose protects against endotoxemic acute renal injury.
D-allose is a monosaccharide. We previously reported that D-allose attenuated renal injury by inhibiting the activation of neutrophils after renal ischemia/reperfusion. Lipopolysaccharide (LPS) triggers sepsis syndrome by activating monocytes to produce proinflammatory cytokines, including tumor necrosis factor (TNF)-alpha, which potently stimulates the activation of neutrophils. This study was undertaken to examine the effects of D-allose on renal injury in the systemic inflammatory response induced by LPS administration, with emphasis on systemic TNF-alpha and the activation of neutrophils in the rat kidney. Serum and renal TNF-alpha, renal cytokine-induced neutrophil chemoattractant (CINC)-1, and myeloperoxidase (MPO) concentrations, and renal function after LPS administration were evaluated. D-allose (400 mg/kg body weight) inhibited LPS-induced increases in serum and renal TNF-alpha concentrations and renal CINC-1 and MPO concentrations after LPS administration, as well as the subsequent neutrophil-mediated renal injury. These findings may have important implications in understanding the biologic functions of D-allose. D-allose may prove useful in protecting against acute renal injury in systemic inflammatory responses to LPS.
Department of Anesthesiology and Emergency Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa 761-0793, Japan. mueki@med.kagawa-u.ac.jp
Masaaki
M
Ueki
Takehiko
T
Asaga
Kousuke
K
Chujo
Junichiro
J
Ono
Yasuyuki
Y
Iwanaga
Satoshi
S
Taie
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000276:immunology* / Q000517:prevention & control*; D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D005947:Glucose / Q000008:administration & dosage*; D008070:Lipopolysaccharides; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D016207:Cytokines; D008070:Lipopolysaccharides; C002055:allose; D005947:Glucose