[Correlation between VEGF expression and clinical characteristic of patient with non-Hodgkin's lymphoma: an initial study].
OBJECTIVE
To study whether VEGF expression is associated with clinical characteristics such as gender, age, aggressive, stage, B-symptoms and complete remission (CR) rate of patients with non-Hodgkin's lymphoma.


METHODS
Expression of VEGF had been tested in 98 biopsy samples by immunohistochemical method as LSAB. Chi-Square test was used to do the statistical analysis of ratio comparison between different groups.


RESULTS
Comparing VEGF positive rates grouped by sexuality, age, aggressive grade or stage, the results suggested no significant correlation between them. VEGF positive rate of patients accompanied with B-symptoms was 86.1%, versus 51.6% of patients B-symptoms free, P = 0.001. Among 94 patients, their responses to chemotherapy could be estimated, delaminated by B-symptoms, and the CR rate of VEGF negative group was significantly higher, P values were 0.000 and 0.028.


CONCLUSIONS
Expression of VEGF is associated with B-symptoms and poor response to chemotherapy in patients with non-Hodgkin's lymphoma, there was not any relationship to have been found between VEGF expression and sexuality, age, aggressive grade, stage.
Zhu
Jiang
J
Department of Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Wang
Wei-Ya
WY
Jiang
Ming
M
Yang
Yu
Y
Hou
Mei
M
D000328:Adult; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*
D042461:Vascular Endothelial Growth Factor A