Raised serum levels of matrix metalloproteinase-9 in women with polycystic ovary syndrome and its association with insulin-like growth factor binding protein-1.
BACKGROUND
It has been suggested in recent studies that matrix metalloproteinases (MMPs) may be implicated in the pathogenesis of polycystic ovary syndrome (PCOS) through regulating ovarian tissue remodeling. In addition to degrading the extracellular matrix, MMPs exhibit the ability to cleave insulin-like growth factor binding protein-1 (IGFBP-1), the major regulator of insulin-like growth factor-I (IGF-I) in serum. The present study aimed to investigate the possible role of MMPs in the pathophysiology of PCOS.


METHODS
Serum levels of MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1), IGF-I and IGFBP-1 were measured in 42 patients with PCOS and 30 healthy women with regular menstruation, matched for age and body mass index. Correlation between IGFBP-1 and other parameters in the PCOS group was analyzed by Pearson's linear correlations.


RESULTS
Serum MMP-9 concentrations and MMP-9/TIMP-1 ratios were significantly higher in PCOS women than in controls. Serum levels of IGFBP-1 were markedly lower in the PCOS group. There was a negative correlation between serum IGFBP-1 and MMP-9 in women with PCOS.


CONCLUSIONS
Our results raise the possibility that MMPs may be implicated in the pathophysiology of PCOS either by regulating ovarian tissue remodeling or indirectly by facilitating IGF-I bioavailability through proteolysis of IGFBP-1.
Department of Reproductive Medicine, First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
Bin
B
Liu
Li-Ying
LY
Cai
Hui-Ming
HM
Lv
Lei
L
Xia
Ya-Juan
YJ
Zhang
Hong-Xiu
HX
Zhang
Yong-Mei
YM
Guan
D000328:Adult; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000201:enzymology; D018709:Statistics, Nonparametric; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood
D018970:Insulin-Like Growth Factor Binding Protein 1; D019715:Tissue Inhibitor of Metalloproteinase-1; D007334:Insulin-Like Growth Factor I; D020780:Matrix Metalloproteinase 9