Synthesis of an ent-halimanolide from ent-halimic acid.
An efficient synthesis of ent-halimanolide 2 (15,16-epoxy-12-oxo-ent-halima- 5(10),13(16),14-trien-18,2beta-olide), from ent-halimic acid has been achieved, corroborating the structure of the natural compound and establishing its absolute configuration.
Marcos
Isidro S
IS
Departamento de Química Orgánica, Universidad de Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain. ismarcos@usal.es
Conde
Almudena
A
Moro
Rosalina F
RF
Basabe
Pilar
P
Díez
David
D
Mollinedo
Faustino
F
Urones
Julio G
JG
D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D019665:Euphorbiaceae / Q000737:chemistry
D004224:Diterpenes; C530794:ent-halimanolide 2; C530795:ent-halimic acid