[Thyroid hormone and its receptors: have mouse genetics clarified the situation?].
In vertebrates, the active form of thyroid hormone (T3) acts directly on transcription by changing the conformation of the TR nuclear receptors (TR alpha 1, TR beta 1 et TR beta 2) which are encoded by the THRA and THRB genes. These receptors are bound to DNA at specific response elements in a ligand independent manner. Mouse genetics have clarified the respective function of each receptor isoform, mainly reflecting THRA and THRB expression patterns. It also revealed the importance of negative regulation by unliganded receptors not only in pathological but also in physiological situations.
Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Université de Lyon, UMR INRA CNRS, 5242 IFR128, 46 allée d'Italie, 69364 Lyon Cedex 07, France. frédéric.flamant@ens-lyon.fr
Frédéric
F
Flamant
Laure
L
Quignodon
D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry; D004247:DNA / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects; D051379:Mice / Q000235:genetics*; D018345:Mice, Knockout; D009154:Mutation; D011487:Protein Conformation / Q000187:drug effects; D011988:Receptors, Thyroid Hormone / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D037021:Thyroid Hormone Receptors alpha / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D037042:Thyroid Hormone Receptors beta / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D014284:Triiodothyronine / Q000494:pharmacology*
D011988:Receptors, Thyroid Hormone; D037021:Thyroid Hormone Receptors alpha; D037042:Thyroid Hormone Receptors beta; D014284:Triiodothyronine; D004247:DNA