Highly anti-selective asymmetric nitro-mannich reactions catalyzed by bifunctional amine-thiourea-bearing multiple hydrogen-bonding donors.
Highly anti-selective and enantioselective nitro-Mannich reactions have been achieved for a broad spectrum of substrates catalyzed by chiral bifunctional multiple hydrogen-bonding-donor amine-thioureas. Multiple hydrogen-bonding donors play a significant role in accelerating reactions and improving yields, diastereoselectivities, and enantioselectivities.
College of Chemistry and Molecular Sciences, Wuhan University, P.R. China. cjwang@whu.edu.cn
Chun-Jiang
CJ
Wang
Xiu-Qin
XQ
Dong
Zhi-Hai
ZH
Zhang
Zhi-Yong
ZY
Xue
Huai-Long
HL
Teng