Combination iminium, enamine and copper(I) cascade catalysis: a carboannulation for the synthesis of cyclopentenes.
A one-pot, multistep reaction cascade to cyclopentenes from alpha,beta-unsaturated ketones and propargylated carbon acids through a combination of organocatalysis and transition metal ion catalysis is reported; the reaction cascade is simple to perform, occurs under mild conditions and is broad in scope.
School of Chemistry, The University of Manchester, Oxford Road, Manchester, UK M13 9PL.
Ting
T
Yang
Alessandro
A
Ferrali
Leonie
L
Campbell
Darren J
DJ
Dixon
D000480:Alkynes / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure
D000480:Alkynes; D000588:Amines; D003517:Cyclopentanes; D007097:Imines; D002244:Carbon; D003300:Copper