Differences in regional blood volume during a 28-day period of abstinence in chronic cannabis smokers.
Cerebral blood volume (CBV) studies have provided important insight into the effects of illicit substances such as cannabis. The present study examined changes in regional blood volume in the frontal and temporal lobe, and the cerebellum during 28 days of supervised abstinence from cannabis. Dynamic susceptibility contrast MRI (DSCMRI) data were collected on 15 current, long-term cannabis users between 6 and 36 h after the subjects' last reported cannabis use (Day 0), and again after 7 and 28 days of abstinence. Resting state CBV images were also acquired on 17 healthy comparison subjects. The present findings demonstrate that at Day 7, cannabis users continued to display increased blood volumes in the right frontal region, the left and right temporal regions, and the cerebellum. However, after 28 days of abstinence, only the left temporal area and cerebellum showed significantly increased CBV values in cannabis users. These findings suggest that while CBV levels begin to normalize with continued abstinence from cannabis, specifically in frontal areas, other temporal and cerebellar brain regions show slower CBV decreases.
Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Belmont, MA 02478, United States. jtsneider@mclean.harvard.edu
Jennifer T
JT
Sneider
Harrison G
HG
Pope
Marisa M
MM
Silveri
Norah S
NS
Simpson
Staci A
SA
Gruber
Deborah A
DA
Yurgelun-Todd
D000328:Adult; D001810:Blood Volume / Q000502:physiology*; D001921:Brain / Q000098:blood supply*; D001931:Brain Mapping; D013759:Dronabinol / Q000097:blood; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D002189:Marijuana Abuse / Q000097:blood / Q000503:physiopathology*; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000503:physiopathology*; D013997:Time Factors
D013759:Dronabinol