Ligand-free copper-catalyzed C-S coupling of aryl iodides and thiols.
A protocol for the copper-catalyzed aryl-sulfur bond formation between aryl iodides and thiophenols is reported. The reaction is catalyzed by a low amount (1-2.5 mol %) of readily available and ligand-free copper iodide salt. A variety of diaryl thioethers are synthesized under relatively mild reaction conditions with good chemoselectivity and functional group tolerance.
Sperotto
Elena
E
Chemical Biology and Organic Chemistry, Debye Institute for Nanomaterials Science, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
van Klink
Gerard P M
GP
de Vries
Johannes G
JG
van Koten
Gerard
G
D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry; D012997:Solvents; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*
D007454:Iodides; D008024:Ligands; D010636:Phenols; D012997:Solvents; D013438:Sulfhydryl Compounds; D013455:Sulfur; D002244:Carbon; D003300:Copper; C042983:thiophenol