Decelerated chirality interconversion of an optically inactive 3(10)-helical peptide by metal chelation.
A dynamically optically inactive 3(10)-helical peptide possessing metal chelating ability between the side-chains at the i and i + 3th residues was synthesized, and its metal complexes were shown to stabilize the peptide structure and the helical sense.
Ousaka
Naoki
N
Japan Science and Technology Agency, ERATO-SORST Kuroda Chiromorphology Team, 4-7-6, Komaba, Tokyo, 153-0041, Japan. ousaka@chiromor2.erato.rcast.u-tokyo.ac.jp
Tani
Norihiko
N
Sekiya
Ryo
R
Kuroda
Reiko
R
D002614:Chelating Agents / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry*; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
D002614:Chelating Agents; D008670:Metals; D010455:Peptides