The role of Sox9 in prostate development.
The mammalian prostate arises from the urogenital sinus under the influence of testicular androgens. Few factors have been identified to be important in the early stages of prostate development. Here we review the role of the transcription factor Sox9 in prostate development. Sox9 is a member of the Sox gene family that plays an important role during embryogenesis in the cellular differentiation of various tissues, including testicular Sertoli cells, neural crest cells and chondrocytes. This gene is expressed in the epithelia of all mouse prostatic lobes from the initial stages of their development. Mice with a prostate specific deletion of Sox9 showed a lack of ventral prostate development and abnormal anterior prostate differentiation. In depth analysis of these mutant animals suggested that Sox9 is required for the early differentiation of the prostate bud epithelia, consistent with the function of this factor in other developmental processes. These studies also revealed different phases of prostate bud development. These phases were characterized by being dependent on different molecular pathways and having lobe specific properties. Future studies on the identification of pathways regulated by Sox9 will provide insight into the molecular networks required for prostate epithelia differentiation.
Section of Gene Function and Regulation, Institute of Cancer Research, 237 Fulham Road, London SW36JB, UK.
Martin K
MK
Thomsen
Jeffrey C
JC
Francis
Amanda
A
Swain
D000818:Animals; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000502:physiology; D006801:Humans; D008297:Male; D011467:Prostate / Q000254:growth & development*; D011471:Prostatic Neoplasms / Q000503:physiopathology*; D055758:SOX9 Transcription Factor / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; D005346:Fibroblast Growth Factors