Growth hormone (GH) treatment does not restore endothelial function in children with GH deficiency.
BACKGROUND
In adults with growth hormone (GH) deficiency (GHD), GH treatment restores impaired endothelial function, a precursor of cardiovascular disease. Its effect in children with GHD is unknown.


METHODS
Three months of GH (0.3 mg/kg/wk) were given to nine children with GHD. Endothelial function was measured via reactive hyperemic response. Forearm blood flow (FBF, strain gauge plethysmography) was measured before and after 5 min of upper arm arterial occlusion. Blood pressure and lipid, insulin and glucose levels were measured. Pretreatment endothelial function was compared to 18 previously studied control children.


RESULTS
Percent fall in forearm vascular resistance was greater in controls (81.2 +/- 1.9%) than in children with GHD (69.6 +/- 5.3%, p = 0.021) but was not affected by GH (60.6 +/- 7.5%). GH markedly increased HOMAIR (21 +/- 7 versus 43 +/- 8, p = 0.004). Plasma lipid levels did not significantly differ.


CONCLUSIONS
These results indicate that endothelial function is impaired in children with GHD. GH therapy does not restore the impairment.
Hoffman
Robert P
RP
Division of Pediatric Endocrinology, Department of Pediatrics, The Ohio State University College of Medicine Children's Hospital, Columbus, OH 43205, USA. robert.hoffman@nationwidechildrens.org
D001783:Blood Flow Velocity; D001794:Blood Pressure; D002648:Child; D003677:Deficiency Diseases / Q000188:drug therapy; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005542:Forearm / Q000098:blood supply; D020249:Hormone Replacement Therapy; D019382:Human Growth Hormone / Q000008:administration & dosage / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D008297:Male
D019382:Human Growth Hormone