Correlation between the expression of aquaporin 1 and hypoxia-inducible factor 1 in breast cancer tissues.
The correlation between aquaporin 1 (AQP1) and hypoxia-inducible factor 1 (HIF 1) in breast cancer tissues was preliminarily studied. In 155 cases of breast cancer, the expression levels of AQP1 were detected by immunohistochemistry in HIF1-positive group or HIF1-negative group, and the correlation between AQP1 and HIF1 was analyzed. The overexpression of AQP1 and HIF1 were observed in 155 cases of breast cancer tissues. The expression level of AQP1 in HIF1-positive group was significantly higher than that in HIF1-negative group. The positive expression rate of AQP1 was 296.55+/-24.67 and 168.37+/-37.53 in HIF1-positive group and HIF1-negative group respectively with the difference being very significant between them (P<0.001). It was concluded that AQP1 was overexpressed in the HIF1-positive group and there were some correlations between AQP1 and HIF1, suggesting they interact each other and regulate the oncogenesis of breast cancer.
Department of Comprehensive Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. tjyin@tjh.tjmu.edu.cn
Tiejun
T
Yin
Shiying
S
Yu
Liang
L
Xiao
Jun
J
Zhang
Chong
C
Liu
Yunping
Y
Lu
Chengping
C
Liu
D000328:Adult; D000368:Aged; D051398:Aquaporin 1 / Q000096:biosynthesis*; D001943:Breast Neoplasms / Q000378:metabolism*; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D000860:Hypoxia; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods; D008875:Middle Aged; D009362:Neoplasm Metastasis; D015398:Signal Transduction
D051793:Hypoxia-Inducible Factor 1; D051398:Aquaporin 1