Hypaphorine, an indole alkaloid from Erythrina velutina, induced sleep on normal mice.
An indole alkaloid (hypaphorine (1)) was isolated from Brazilian medicinal plant, Erythrina velutina (Leguminosae). This compound was investigated for sleep promoting effects in mice, and the results showed that it significantly increased non-rapid eye movement (NREM) sleep time during the first hour after its administration. The NREM sleep time was enhanced by 33% in the experimental mice when compared to that of the controls. This study therefore confirmed its sleep promoting property.
Ozawa
Masaaki
M
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10, Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Honda
Kazuki
K
Nakai
Izumi
I
Kishida
Akio
A
Ohsaki
Ayumi
A
D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D004895:Erythrina / Q000378:metabolism; D026121:Indole Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D008956:Models, Chemical; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D013997:Time Factors
D026121:Indole Alkaloids; D007211:Indoles; D010936:Plant Extracts; C001529:lenticin