Anatomopathological study in BALB/c mice brains experimentally infected with Toxoplasma gondii.
Toxoplasmosis is one of the most important diseases of the nervous central system, leading to severe symptoms and, many times, irreversible sequelae. This work demonstrated the main anatomopathological lesions caused by Toxoplasma gondii in brains from experimentally infected BALB/c mice. We analyzed 51 cases of mice that developed toxoplasmosis after experimental infection by intraperitoneal inoculation of blood, amniotic liquid and cerebrospinal fluid from fetuses, newly born children and pregnant women with clinical and laboratory signals of toxoplasmosis. In all experiments where we detected the parasite in mice we also detected pathological lesions in the animal brains with great polymorphism between experiments. Edema was the most found lesion in all cases. Besides, it was possible to demonstrate the inflammatory process in 82.4% of cases and necrosis in 64.7% of cases, in agreement with the literature that describes severe neurological damage in its hosts.
Postgraduate Program from the Tropical Pathology and Public Health Institute, Federal University of Goias, Goiânia, GO, Brazil.
Marcos Gontijo da
MG
Silva
Ruy de Souza
Rde S
Lino
Tatiane Luiza
TL
da Costa
Joanna D'Aac Herzog
JD
Soares
Waldemar Naves
WN
do Amaral
Mariza Martins
MM
Avelino
Ana Maria
AM
de Castro
D000818:Animals; D001921:Brain / Q000469:parasitology / Q000473:pathology*; D020808:Central Nervous System Protozoal Infections / Q000469:parasitology / Q000473:pathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D014124:Toxoplasmosis, Animal / Q000473:pathology*