Expression of apoptosis related protein in skin lesions of lichen planus and its implication.
In order to investigate the role of Caspase-3 and Bax in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of Caspase-3 and Bax in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rate of Caspase-3 and Bax expression in lichen planus were significantly higher than that in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the increase of Caspase-3 and that of Bax in lichen planus. The expression of Caspase-3 and Bax might play an important role in the development of lichen planus.
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. CXE911@hotmail.com
Xu'e
X
Chen
Yan
Y
Wu
Jiawen
J
Li
Zhixiang
Z
Liu
Qing
Q
Yue
Houjun
H
Liu
D000328:Adult; D017209:Apoptosis; D001706:Biopsy; D053148:Caspase 3 / Q000096:biosynthesis*; D005260:Female; D005786:Gene Expression Regulation; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008010:Lichen Planus / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D012867:Skin / Q000378:metabolism* / Q000473:pathology*; D051028:bcl-2-Associated X Protein / Q000096:biosynthesis* / Q000378:metabolism
D051028:bcl-2-Associated X Protein; D053148:Caspase 3