Effect of ginseng mixture on osteoporosis in ovariectomized rats.
In this study, the authors have characterized the effect of HER-S (red ginseng, Angelicae gigantis Radix, Phyllostachys folium, and soybean extracts) on osteoporosis-associated phenomena in ovariectomized (OVX) rats by measuring body weights and bone histomorphometries in control, sham, OVX, OVX(beta-estradiol-treated), and OVX(HER-S-treated) rats. Light microscopic analyses showed a porous or eroded appearance on the femoral trabecular bone surface in OVX rats, whereas the femoral trabecular bone surfaces of the other groups (control, sham, OVX(17beta-estradiol-treated), and OVX(HER-S-treated) rats) were composed of fine particles. The femoral trabecular bone area and number were decreased in OVX rats, but these reductions were significantly prevented by the administration of HER-S for 7 weeks, similar to estrogen. In the blood biochemistry results, serum phosphorus, calcium, T(3), and T(4) remained unchanged, but blood estrogen levels were significantly increased in HER-S-treated rats, which suggests that estrogen is related to the mechanism of the HER-S-induced antiosteoporosis function in OVX rats.
Kim
Hyung-Ryong
HR
Department of Dental Pharmacology, Dental School, Wonkwang University, Iksan, Chonbuk, Republic of Korea.
Cui
Yan
Y
Hong
Su-Jung
SJ
Shin
Sook-Jeong
SJ
Kim
Do-Sung
DS
Kim
Na-Mi
NM
So
Seung-Ho
SH
Lee
Seong-Kye
SK
Kim
Eun-Cheol
EC
Chae
Soo-Wan
SW
Chae
Han-Jung
HJ
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D004958:Estradiol / Q000097:blood / Q000494:pharmacology; D005260:Female; D005269:Femur / Q000378:metabolism / Q000473:pathology; D010024:Osteoporosis / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D010052:Ovariectomy; D005894:Panax / Q000737:chemistry*; D010758:Phosphorus / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013963:Thyroid Hormones / Q000097:blood; D013997:Time Factors
D010936:Plant Extracts; D013963:Thyroid Hormones; D010758:Phosphorus; D004958:Estradiol; D002118:Calcium