A histologic review of 27 patients with lichen planopilaris.
BACKGROUND
Lichen planopilaris (LPP) is a potential trichologic emergency that can result in permanent scarring alopecia. Histopathology is a key component of the diagnostic work-up.


OBJECTIVE
To identify the key histologic features that characterize LPP in order to facilitate diagnosis, ultimately leading to improved patient outcomes.


METHODS
Scalp biopsy specimens from 27 confirmed cases of LPP were reviewed in a blinded fashion to determine diagnostically helpful histologic features.


RESULTS
Absence of arrector pili muscles and sebaceous glands, a perivascular and perifollicular lymphocytic infiltrate in the reticular dermis and mucinous perifollicular fibroplasia within the upper dermis with absence of interfollicular mucin, and superficial perifollicular wedge-shaped scarring were characterizing features.


CONCLUSIONS
Sample size was limited, given that biopsy specimens were taken from lesions at varying stages of evolution and findings vary with disease stage.


CONCLUSIONS
This study confirms many previously reported histologic features and highlights new characterizing features of mucinous perifollicular fibroplasia.
Tandon
Yasmeen K
YK
Faculty of Medicine, North Eastern Ohio Universities College of Medicine, Rootstown, Ohio, USA.
Somani
Najwa
N
Cevasco
Nathaniel C
NC
Bergfeld
Wilma F
WF
D000328:Adult; D000368:Aged; D000505:Alopecia / Q000209:etiology / Q000473:pathology*; D001706:Biopsy; D002921:Cicatrix / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012535:Scalp / Q000473:pathology*; D012536:Scalp Dermatoses / Q000175:diagnosis / Q000473:pathology*