Iridium-catalyzed enantioselective hydrogenation of alpha,beta-unsaturated carboxylic acids.
A highly efficient iridium-catalyzed hydrogenation of alpha,beta-unsaturated carboxylic acids has been developed by using chiral spiro-phosphino-oxazoline ligands, affording alpha-substituted chiral carboxylic acids in exceptionally high enantioselectivities and reactivities.
Li
Shen
S
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
Zhu
Shou-Fei
SF
Zhang
Can-Ming
CM
Song
Song
S
Zhou
Qi-Lin
QL