Role of oxidative and antioxidative parameters in etiopathogenesis and prognosis of panic disorder.
Free radicals have been implicated in some psychiatric disorders. This study aimed to investigate the role of oxidative and antioxidative parameters in etiopathogenesis and prognosis of panic disorder (PD), using novel methods for measurement of total oxidant and antioxidant statuses. Nineteen PD patients and 40 healthy subjects were recruited. Both total antioxidant status and oxidative stress index, and ceruloplasmin levels of PD patients were significantly higher in PD patients. Total oxidant status and oxidative stress index decreased after treatment. This study suggests an oxidative imbalance in PD and treatment can reverse overall oxidative imbalance.
Ersoy
Mehmet Akif
MA
Department of Psychiatry, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey. akifersoy@gmail.com
Selek
Salih
S
Celik
Hakim
H
Erel
Ozcan
O
Kaya
Mehmet Cemal
MC
Savas
Haluk A
HA
Herken
Hasan
H
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D001923:Brain Chemistry / Q000502:physiology; D002570:Ceruloplasmin / Q000032:analysis / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D016584:Panic Disorder / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D011379:Prognosis; D013457:Sulfur Compounds / Q000378:metabolism; D015854:Up-Regulation / Q000502:physiology
D000975:Antioxidants; D015415:Biomarkers; D005609:Free Radicals; D016877:Oxidants; D013457:Sulfur Compounds; D002570:Ceruloplasmin