Anticancer photodynamic and non-photodynamic effects of pterin derivatives on a pancreatic cancer cell line.
To evaluate the feasibility of two kinds of pterin derivatives, 2-(N,N-dimethylaminomethyleneamino)-6-formyl-3-pivaloylpteridin-4-one (DFP) and 2-(N,N-dimethylaminomethyleneamino)-3-pivaloylpteridin-4-one (DP), as anticancer drugs, their photodynamic and non-photodynamic effects on pancreatic cancer cell line Panc-1 cells were examined. For photodynamic effects, cell death 48 h after UV-A irradiation was more prominent in cells preloaded with DP than DFP. When cells were simply incubated for 96 h without irradiation, DFP induced cell death, while DP suppressed cell proliferation. Furthermore, DP was much more soluble in water than DFP. These findings collectively indicated that DP is more feasible as an anticancer drug than DFP.
Miyoshi
Takashi
T
Department of Hematology and Oncology, Kyoto University Hospital, Kyoto, Japan.
Arai
Toshiyuki
T
Nonogawa
Mitsuru
M
Makino
Keisuke
K
Mori
Hiroko
H
Yamashita
Kouhei
K
Sasada
Masataka
M
D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011621:Pteridines / Q000494:pharmacology*; D011622:Pterins / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism
C530881:2-(N,N-dimethylaminomethyleneamino)-3-pivaloylpteridin-4-one; C504029:2-(N,N-dimethylaminomethyleneamino)-6-formyl-3-pivaloylpteridin-4-one; D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D011621:Pteridines; D011622:Pterins; D017382:Reactive Oxygen Species