Significance of pretransplant urinary tract infection in short-term renal allograft function and survival.
Renal transplant recipients are susceptible to postoperative infections, among which those in the urinary tract (UTI) are the most common. We examined the effect of pretransplant bacterial UTI on the incidence of posttransplant UTI as well as complications and short-term outcomes.


METHODS
We examined the case records of 100 patients who underwent living-related donor renal transplantation at our institute from November 2006 to June 2007.


RESULTS
Nineteen patients had positive pretransplant bacterial urine cultures and four required native nephrectomy for control of persistent bacterial UTI. All patients were transplanted under a tolerance induction protocol using low-dose immunosuppression after negative suprapubic culture reports. There was no urinary leak/obstruction or vascular complication. The incidence of postoperative bacterial UTI was 31.6% (6 of 19) compared with 6.2% (6 of 81) among patients without pretransplant UTI. E. coli was the most common isolated organism. All patients were doing well with 100% graft survival at 3 months and a mean serum creatinine of 1.27 mg%.


CONCLUSIONS
Preoperative UTI predicted an increased likelihood of postoperative UTI without a significant effect on graft/patient survival and graft function.
G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre-Dr. H.L. Trivedi Institute of Transplantation Sciences, Gujarat, India.
S J
SJ
Rizvi
R
R
Chauhan
R
R
Gupta
P
P
Modi
D000328:Adult; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000145:classification / Q000453:epidemiology; D003404:Creatinine / Q000097:blood; D004231:Diuresis; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality / Q000502:physiology*; D019520:Living Donors; D011184:Postoperative Period; D011300:Preoperative Care; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000150:complications*
D003404:Creatinine