Behavioral symptoms after pallido-nigral lesions: a clinico-pathological case.
A 59-year-old patient presented with compulsive behaviors and lasting apathy after carbon monoxide intoxication. The apathy could be overcome by external stimulation (self-activation deficit). There was severe neuronal loss bilaterally in the anterior part of the pallidum and in the substantia nigra, pars reticulata. This first clinico-pathological case of a self-activation deficit illustrates the dissociation between motor and behavioral symptoms in lesions of the pallido-nigral complex, with the behavioral symptoms being related to lesions of the substantia nigra, pars reticulata and of the anterior part of the pallidum.
Raymond Escourolle Neuropathology Laboratory, Hopital de La Salpetriere, Inserm U679, APHP, Pierre et Marie Curie Paris VI University, Paris, France.
Julien
J
Adam
Michel
M
Baulac
Jean-Jacques
JJ
Hauw
Dominique
D
Laplane
Charles
C
Duyckaerts
D000342:Affective Symptoms / Q000188:drug therapy / Q000209:etiology*; D001154:Art; D001284:Atrophy; D001921:Brain / Q000473:pathology; D002114:Calcinosis / Q000150:complications / Q000000981:diagnostic imaging; D002249:Carbon Monoxide Poisoning / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000523:psychology*; D002908:Chronic Disease; D003192:Compulsive Behavior / Q000209:etiology* / Q000523:psychology; D004298:Dopamine / Q000627:therapeutic use; D005917:Globus Pallidus / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D013378:Substantia Nigra / Q000473:pathology*; D014057:Tomography, X-Ray Computed
D004298:Dopamine