[Diagnostics and treatment of cholangiocarcinoma].
--Cholangiocarcinoma is a rare malignancy originating from the biliary epithelium. The disease can arise anywhere in the biliary tract: intrahepatic, perihilar or distal. The overall prognosis for cholangiocarcinoma is poor. --The treatment necessitates a multidisciplinary approach. --Radical resection of the extrahepatic bile ducts, usually in combination with concomitant partial liver resection, remains the only curative treatment. --Liver transplantation in combination with neoadjuvant chemoradiation therapy seems to be promising in a highly selected group of patients. --Palliative treatment should be targeted at adequate biliary drainage, preferably by stenting. --Radiotherapy and systemic chemotherapy are not standard treatment and should be applied in an experimental setting only. --New options such as photodynamic therapy and tyrosine kinase inhibitors are promising, but still experimental treatments.
Universitair Medisch Centrum Groningen, Groningen.
H T J
HT
Mantel
R C
RC
Verdonk
H M
HM
van Dullemen
J A
JA
Gietema
M J H
MJ
Slooff
R J
RJ
Porte
D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy; D001653:Bile Ducts, Intrahepatic; D001662:Biliary Tract Surgical Procedures / Q000379:methods*; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D016031:Liver Transplantation; D010166:Palliative Care; D011379:Prognosis; D016896:Treatment Outcome