Preliminary investigation of the central nervous system effects of 'Tira-capeta' (Removing the Devil), a cigarette used by some Quilombolas living in Pantanal Wetlands of Brazil.
During an ethnopharmacological survey carried out among some Quilombolas living in Brazil, 48 plants with possible central nervous system (CNS) action were cited. A mixture of nine plants, known as 'Tira-capeta' (Removing the Devil) cigarette, has been utilized for years as a tonic for the brain. The effects observed after consuming this cigarette are: dizziness, lightness sensation, humor changes, yawns, heavy eyes, hunger, sleep and relaxation. This study aimed to verify the effects of a hydroalcohol extract of 'Tira-capeta' cigarette (ETC), as well as to evaluate the phytochemical profile. The phytochemical screening carried out through characterization reactions, thin layer chromatography and high efficiency liquid chromatography indicated the presence of tannins, phenolic acids, flavonoids, saponins and alkaloids; tannins and phenolic acids being the principal constituents. The pharmacological tests showed that ETC induced a biphasic effect, with intense initial stimulation of the CNS, followed by a general depressor state; decreased the latency for sleeping and increased the total sleeping time (50, 100 and 500 mg/kg), without causing prejudice in motor coordination (doses up to 200 mg/kg); induced catalepsy in mice, verified 10 and 50 min after drug administration (500 mg/kg). Also, no anxiolytic or anxiogenic effects were verified in rats submitted to the elevated plus-maze.
Department of Psychobiology, Universidade Federal de São Paulo, Brazil. elirodri@psicobio.epm.br
Eliana
E
Rodrigues
Bruno
B
Gianfratti
Ricardo
R
Tabach
Giuseppina
G
Negri
Fúlvio R
FR
Mendes
D000818:Animals; D001938:Brazil; D002375:Catalepsy; D002490:Central Nervous System; D020834:Ethnopharmacology; D006801:Humans; D007199:Indians, South American; D008297:Male; D051379:Mice; D009043:Motor Activity; D010946:Plants, Medicinal; D012907:Smoking; D053833:Wetlands