Strategies for the Preparation of Differentially Protected ortho-Prenylated Phenols.
A new process for ortho-prenylation of phenols is presented within the context of known methods. All of the processes are briefly assessed with regards to the substitution patterns and accompanying functional groups tolerated by each strategy. The conclusion reached is that a new procedure using ortho-quinone methides, for which an experimental protocol is provided, offers the greatest generality and flexibility in the preparation of ortho-prenylated phenol derivatives.
Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106, USA Fax +1(805)8935690; E-mail: pettus@chem.ucsb.edu.
Christophe
C
Hoarau
Thomas R R
TR
Pettus