Different prognostic importance of elevated troponin I after percutaneous coronary intervention in acute coronary syndrome and stable angina pectoris.
OBJECTIVE
To investigate the prognostic importance of cardiac troponin I (cTnI) elevation after percutaneous coronary intervention (PCI) in different clinical settings.


METHODS
The study includes 238 patients presenting with acute coronary syndrome (ACS) and 194 patients with stable angina pectoris (SAP). The composite end point of death or hospitalization due to non-fatal myocardial infarction, repeated revascularization or unstable angina, was determined during one year of follow-up.


RESULTS
cTnI elevation after PCI was more frequent in ACS patients than SAP patients. ACS patients with cTnI elevation after PCI had significantly higher number of events than patients with unchanged cTnI status after PCI. SAP patients had generally lower event rate than ACS patients. The event rate was also significantly higher among ACS patients than SAP patients at comparable degrees of cTnI elevation after PCI. There was no difference in events among SAP patients with or without cTnI elevation after PCI.


CONCLUSIONS
cTnI elevation after PCI predicts adverse outcome after one year in patients with ACS, but not in patients with SAP.
Institute for Surgical Research, Rikshospitalet University Hospital, Oslo, Norway. j.a.gravning@medisin.uio.no
Jørgen
J
Gravning
Thor
T
Ueland
Lars
L
Mørkrid
Knut
K
Endresen
Lars
L
Aaberge
John
J
Kjekshus
D054058:Acute Coronary Syndrome / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D000368:Aged; D000787:Angina Pectoris / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism / Q000401:mortality; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D018570:Risk Assessment; D013997:Time Factors; D016896:Treatment Outcome; D019210:Troponin I / Q000097:blood*; D015854:Up-Regulation
D015415:Biomarkers; D019210:Troponin I