[Research update on pharmacogenomics in acute leukemia - review].
Pharmacogenomics, a new subject aiming to elucidate genetic basis for inter individual differences in response on a drug and to predict the safety and efficacy of drugs by the genetic information, which guides to clinical individual therapy, breaks a new way to apply drugs rationally to acute leukemia. This article reviewed the enzymes related to metabolism, transport and acting point of the drugs used in the treatment of acute leukemia and discussed the influence of their coding gene's polymorphism on drug adverse effects and disease prognosis.
Li
Lin
L
The State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin 300020, China.
Xiao
Zhi-Jian
ZJ
D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics / Q000639:trends*