Prediction of survival after liver transplantation by pre-transplant parameters.
OBJECTIVE
Score-based medical urgency criteria are used for necessity-oriented liver transplantation (OLT) but lead to an increasing number of complications in patients with reduced post-OLT survival. A prediction of outcome would improve preoperative patient selection and management.


METHODS
One-hundred-and-thirty-three consecutive adult patients (63.9% men, mean age 47.4+/-11.2 years) given transplants between May 2004 and November 2005 at the Hannover Medical School were analysed retrospectively using univariate and multivariate methods.


RESULTS
Indications were: 27.1% viral hepatitis, 19.6% primary sclerosing cholangitis, 15.0% alcoholic liver disease, 7.5% metabolic liver disease, 6.8% primary biliary cirrhosis. Overall, 12-month patient survival was 81.2%. The mean MELD score at OLT was 14.5+/-5.3 and 12-month survival with MELD >16 (71.7%) and <16 (86.2%) differed significantly (p=0.041). Predictors of 12-month mortality included age (53.2+/-9.4 versus 46.1+/-11.2 years; p=0.004), lower cholinesterase (2.9+/-1.88 versus 3.7+/-2.02 kU/l; p=0.026) and serum creatinine (160.4+/-186.8 versus 77.7+/-31.6 micromol/l; p=0.007), with creatinine and cholinesterase as independent parameters. Based on these parameters, a model for predicting patient survival after liver transplantation was calculated and validated in a second independent cohort of 87 OLT patients. This score identified a high-risk group and a low-risk group (overall survival 47.4 versus 91.2%; p<0.001) with a specificity of 87.3% and a sensitivity of 68.75%.


CONCLUSIONS
Age, pre-OLT creatinine and cholinesterase are predictors of short-term post-OLT survival and may be helpful as a bedside score in pre-OLT clinical management, outcome prediction and decision-making.
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Tobias J
TJ
Weismüller
Jana
J
Prokein
Thomas
T
Becker
Hannelore
H
Barg-Hock
Jürgen
J
Klempnauer
Michael P
MP
Manns
Christian P
CP
Strassburg
D000367:Age Factors; D015992:Body Mass Index; D002802:Cholinesterases / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011379:Prognosis; D015996:Survival Rate; D014850:Waiting Lists
D003404:Creatinine; D002802:Cholinesterases