Assessment of arterial characteristics in human atherosclerosis by extracting optical properties from polarization-sensitive optical coherence tomography.
In this research, we assessed arterial characteristics in human atherosclerosis by determining both scattering and birefringence properties of vessel tissue from polarization-sensitive optical coherence tomography (PS-OCT) images. We demonstrated that optical characteristics including scattering coefficient (mu(s)), effective anisotropy factor (g(eff)), birefringence coefficient (Delta n), and fast-axis angle (beta) of normal and different kinds of atherosclerotic lesions in human vessels can be quantitatively described. Based on our findings, a quantitative PS-OCT image criterion for plaque characterization was constructed.
Institute of Electro-optical Science and Technology, National Taiwan Normal University, 88, Sec. 4, Ting-Chou Road, Taipei 116, Taiwan. kwchuan@ntnu.edu.tw
Wen-Chuan
WC
Kuo
Ming-Wei
MW
Hsiung
Jeou-Jong
JJ
Shyu
Nai-Kuan
NK
Chou
Po-Nien
PN
Yang
D000465:Algorithms; D001158:Arteries / Q000473:pathology*; D050197:Atherosclerosis / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008859:Microscopy, Polarization / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000379:methods*