Chemoembolization of hepatic metastases from ocular melanoma: assessment of response with contrast-enhanced and diffusion-weighted MRI.
OBJECTIVE
The purpose of this study was to assess the utility of assessment of tumor size and enhancement with diffusion-weighted and conventional MRI in the evaluation of response to transarterial chemoembolization therapy for metastatic ocular melanoma.


CONCLUSIONS
In patients with ocular melanoma and liver metastasis treated with transarterial chemoembolization, functional MRI showed significant changes in the lesions. These changes included a decrease in tumor enhancement and an increase in the apparent diffusion coefficient of the tumor, suggesting increasing tumor necrosis and cell death.
Buijs
Manon
M
Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, 601 N Caroline St., Rm. 3235A, Baltimore, MD 21287, USA.
Vossen
Josephina A
JA
Hong
Kelvin
K
Georgiades
Christos S
CS
Geschwind
Jean-Francois H
JF
Kamel
Ihab R
IR
D000368:Aged; D016461:Chemoembolization, Therapeutic; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005134:Eye Neoplasms / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000628:therapy; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000556:secondary / Q000628:therapy; D017063:Outcome Assessment, Health Care / Q000379:methods; D011379:Prognosis; D016896:Treatment Outcome
D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA