Tumor promoting or tumor suppressing of NF-kappa B, a matter of cell context dependency.
Nuclear factor-kappa B (NF-kappa B) and its activating signaling pathways are critical regulators for cell lineage development, growth, differentiation, apoptosis, and tumorigenic transformation. As one of the most important transcription factors, NF-kappa B has been implicated in the transcriptional upregulation of a number of cytokines, adhesion molecules, growth factors, oncogenes, antiapoptotic proteins, some proapoptotic factors, and even certain viral genes. The role of NF-kappa B on tumor promoting has been well-documented in the past two decades. However, during the past few years, a considerable number of studies suggested that NF-kappa B and its activating signaling molecules may act as tumor suppressors under some circumstances. Thus, it is highly possible that tumor promoting or tumor suppressing of NF-kappa B signaling is determined by the type of cells, stimuli, simultaneous or asynchronous intracellular signals, and other cellular contexts.
Pathology and Physiology Research Branch, The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. LFD3@cdc.gov
Fei
F
Chen
Kevin
K
Beezhold
Vince
V
Castranova
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000276:immunology*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D016166:Free Radical Scavengers / Q000276:immunology; D019337:Hematologic Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology; D016328:NF-kappa B / Q000235:genetics* / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000235:genetics / Q000276:immunology / Q000473:pathology; D018384:Oxidative Stress / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*; D025521:Tumor Suppressor Proteins / Q000276:immunology*
D016166:Free Radical Scavengers; D016328:NF-kappa B; D025521:Tumor Suppressor Proteins