Reduced biocide susceptibility in Candida albicans biofilms.
Candida biofilm formation is common during infection and environmental growth. We tested the impacts of three biocides (ethanol [EtOH], H(2)O(2), and sodium dodecyl sulfate) on Candida albicans, C. parapsilosis, and C. glabrata biofilms. Higher concentrations of the biocides were required for efficacy against biofilms than for efficacy against planktonic controls. A combination study with two biocides (EtOH and H(2)O(2)) and fluconazole demonstrated that the combination had enhanced efficacy.
Departments of Medicine, Cellular and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53792, USA.
Jeniel E
JE
Nett
Kristie M
KM
Guite
Alex
A
Ringeisen
Kathleen A
KA
Holoyda
David R
DR
Andes
D000935:Antifungal Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002175:Candida / Q000187:drug effects / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D041221:Candida glabrata / Q000187:drug effects / Q000254:growth & development; D004202:Disinfectants / Q000494:pharmacology*; D004347:Drug Interactions; D025141:Drug Resistance, Fungal; D004359:Drug Therapy, Combination; D000431:Ethanol / Q000494:pharmacology; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology
D000935:Antifungal Agents; D004202:Disinfectants; D012967:Sodium Dodecyl Sulfate; D000431:Ethanol; D015725:Fluconazole; D006861:Hydrogen Peroxide