Fabrication of an electrically conductive mixed self-assembled monolayer and its application in an electrochemical immunosensor.
Oligophenylethynylene thiol containing carboxylic acid in the tail group as a conducting wire bioreceptor was synthesized, and then its electrical property was investigated from the measurement of scanning tunneling microscopy (STM). Mixed self-assembled monolayer (SAM) consisting of 4-(2-(4-acetylthio)phenyl)ethynyl) benzoic acid (APBA) and butanethiol was fabricated in order to improve the electrical conductivity owing to the molecular orientation. We have examined the molecular orientation and the electrochemical activity of mixed SAM via X-ray photoelectron spectroscopy (XPS) and cyclic voltammetry (CV). Especially, the prepared mixed SAM used as a bioreceptor in electrochemical prostate specific antigen (PSA) immunosensor showed higher electrochemical activity than that of the other SAMs.
Lee
Jung Bae
JB
Interdisciplinary Program of Integrated Biotechnology, Sogang University, Seoul 121-742, Republic of Korea.
Namgung
Miok
M
Lee
Sang-Baek
SB
Oh
Se Young
SY
D004563:Electrochemistry / Q000379:methods*; D006046:Gold / Q000737:chemistry; D006801:Humans; D008297:Male; D016252:Microscopy, Scanning Tunneling / Q000379:methods*; D015394:Molecular Structure; D017430:Prostate-Specific Antigen / Q000032:analysis* / Q000276:immunology; D011471:Prostatic Neoplasms / Q000175:diagnosis; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000276:immunology
D013438:Sulfhydryl Compounds; D006046:Gold; C025540:n-butyl mercaptan; D017430:Prostate-Specific Antigen