[Advance in cytochrome P450 1A2].
CYP1A2 is an important cytochrome P450 enzymes, which is involved in metabolism of many clinical drugs and activation of some precarcinogens. CYP1A2 activity can be influenced by various factors including genetic polymorphism, drugs, food and so on, in which the CYP1A2 genetic polymorphism is the basis of difference on the activity and induction of CYP1A2. Therefore,the genotyping of CYP1A2 plays an important part in individualization of therapy.
Xiao
Peng
P
Institute of Clinical Pharmacology, Central South University, Changsha, China.
Zhou
Hong-hao
HH
D002273:Carcinogens / Q000378:metabolism; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics* / Q000378:metabolism*; D005838:Genotype; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*
D002273:Carcinogens; C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2