Distribution of C14-labelled arteether in kidneys and livers of experimental mice after intramuscular injection.
To study the distribution and localization of oil-soluble arteether in experimental mice, we injected C14-labelled arteether (20 microCi/kg body weight) intramuscularly and measured radioactivity in the blood, kidney, and liver. The labelled arteether distributed and localized more to the kidney (819,180.4 +/- 34,134 dpm/cm3) than the liver (288,628.9 +/- 54,954 dpm/cm3) 4 hours post-injection. The main localization of labelled arteether was in the kidney cortex rather than the medulla (p < 0.05). However, the distribution of radioactivity was homogeneous in the liver. The terminal half-life of labelled arteether in the blood was 1.8 hours. The blood:kidney:liver ratio was 1:5:2. These findings show that labelled arteether was distributed quickly and localized in the cytoplasmic cortex of the kidney and homogeneously in the liver.
Cheeramakara
Cheeraratana
C
Department of Tropical Radioisotopes, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Khachonsaksumet
Vasant
V
Suthisai
Nopachai
N
Nakosiri
Wanyarat
W
Songmuaeng
Kriyaporn
K
Saenghirun
Channarong
C
Phienpicharn
Duangduen
D
Nontprasert
Apichart
A
D000818:Animals; D000962:Antimalarials / Q000493:pharmacokinetics*; D037621:Artemisinins / Q000493:pharmacokinetics*; D002250:Carbon Radioisotopes; D006207:Half-Life; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D014018:Tissue Distribution
D000962:Antimalarials; D037621:Artemisinins; D002250:Carbon Radioisotopes; C055141:artemotil