Permission to proceed: Jak3 and STAT5 signaling molecules give the green light for T helper 1 cell differentiation.
In this issue of Immunity, Shi et al. (2008) identify a previously unknown requirement in T helper cell differentiation, showing that Jak3 and STAT5 are needed to generate chromatin that is permissive to the activating effects of T-bet.
Murphy
Kenneth M
KM
Howard Hughes Medical Institute and Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. kmurphy@wustl.edu
D000818:Animals; D002454:Cell Differentiation; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D053616:Janus Kinase 3 / Q000378:metabolism*; D050799:STAT5 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction; D018417:Th1 Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines; D050799:STAT5 Transcription Factor; D053616:Janus Kinase 3