Indinavir-associated toxicity mimicking urinary tuberculosis in a patient with AIDS.
This case reported to a patient with AIDS who presented persistent sterile leukocyturia and hematuria, lower back pain, bladder suffering symptoms, and renal papillary necrosis which were thought to be secondary to urinary tuberculosis but were demonstrated to be indinavir-associated side effects. The intention of this report is to remind medical professionals involved in the care of HIV+ patients of this possible association in order to avoid unnecessary investigation and to stress the need of careful periodical assessment of renal function and urinalysis in patients treated with indinavir.
Nephrology Department, State University of Londrina, Londrina, PR, Brazil. vddelfino@sercomtel.com.br
Vinicius Daher Alvares
VD
Delfino
Natally Marques
NM
Santiago
Altair Jacob
AJ
Mocelin
Luiz Fernando
LF
Kunii
André Luiz
AL
Bortoliero
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D003937:Diagnosis, Differential; D005919:Glomerular Filtration Rate; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006801:Humans; D019469:Indinavir / Q000009:adverse effects*; D007681:Kidney Papillary Necrosis / Q000139:chemically induced* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D014401:Tuberculosis, Urogenital / Q000175:diagnosis*
D017320:HIV Protease Inhibitors; D019469:Indinavir