Varenicline-induced mixed mood and psychotic episode in a patient with a past history of depression.
Varenicline is a promising agent with demonstrated efficacy in the promotion of smoking cessation. However, from the time of initial trials, it has been associated with significant psychiatric adverse effects. We describe a case where mixed mood and psychotic disturbance developed in an individual with a history of depression and a family history of bipolar disorder. Based on this case, we hypothesize a possible mechanism of action for these adverse effects and preventive measures that could be undertaken in its effective use.
Department of Psychiatry, The Reading Hospital and Medical Center, West Reading, PA 19612, USA.
Andres J
AJ
Pumariega
Robert
R
Nelson
Larry
L
Rotenberg
D014150:Antipsychotic Agents / Q000627:therapeutic use; D000068180:Aripiprazole; D001552:Benzazepines / Q000009:adverse effects* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology / Q000628:therapy; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use; D011605:Psychoses, Substance-Induced / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000523:psychology; D011613:Psychotherapy; D015363:Quinolones / Q000627:therapeutic use; D011810:Quinoxalines / Q000009:adverse effects* / Q000627:therapeutic use; D016540:Smoking Cessation; D013315:Stress, Psychological / Q000150:complications; D000068580:Varenicline
D014150:Antipsychotic Agents; D001552:Benzazepines; D010879:Piperazines; D015363:Quinolones; D011810:Quinoxalines; D000068180:Aripiprazole; D000068580:Varenicline