Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses.
Cytokine gene polymorphisms affect vaccine responses and gender-specific effects are known for many phenotypes. Therefore, this study investigated gender-specific effects of cytokine gene polymorphisms on vaccine responses. In 263 2-year-old subjects selected for parental history of atopy, boys with IL-4 C-589T and IL-4Ralpha I50V genotypes associated with atopy had increased Diptheria Toxoid (DiphTox) and Tetanus Toxoid (TetTox) responses compared with the remaining alleles (IL-4 C-589T: DipTox p=0.01, TetTox p=0.04; IL-4Ralpha.I50V: DipTox p=0.04, TetTox p=0.08). Contrastingly, girls with IL-10 -592C genotypes associated with atopy had lower levels of DiphTox (p=0.03) and TetTox (p=0.02) responses compared with the remaining allele. Additionally, interaction effects were found for IL-4 C-589T (p=0.01) and IL-4Ralpha I50V (p=0.04) polymorphisms. In conclusion, these findings support the interaction of primary genetic and modifying factors on vaccine responses and the importance of atopic genetics to these responses.
Telethon Institute for Child Health Research and Centre for Child Health Research, Perth, Australia. gareth.baynam@health.wa.gov.au
Gareth
G
Baynam
Guicheng
G
Zhang
Siew-Kim
SK
Khoo
Peter
P
Sly
Patrick
P
Holt
Jack
J
Goldblatt
Peter N
PN
Le Souëf
D000907:Antibodies, Bacterial / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D001428:Bacterial Vaccines / Q000276:immunology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D016753:Interleukin-10 / Q000235:genetics; D015847:Interleukin-4 / Q000235:genetics; D008297:Male; D011110:Polymorphism, Genetic; D012727:Sex Characteristics; D014765:Viral Vaccines / Q000276:immunology*
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D014765:Viral Vaccines; D016753:Interleukin-10; D015847:Interleukin-4