A new tyrosinase inhibitor from Crinum yemense as potential treatment for hyperpigmentation.
A new pyran derivative, 6-hydroxy-2H-pyran-3-carbaldehyde, has been isolated from the methanolic extract of Crinum yemense along with the known alkaloid haemanthamine, benzoic acid and 1,1'-bis(1,1'-carboxyethyl) ether which is isolated from a natural source for the first time. Structure elucidation of these compounds based on spectroscopicevidences. The pyran derivative was found to be a tyrosinase inhibitor more potent than kojic acid.
Department of Pharmacognosy, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt.
O B
OB
Abdel-Halim
A M
AM
Marzouk
R
R
Mothana
N
N
Awadh
D000364:Agaricus / Q000201:enzymology; D000447:Aldehydes / Q000302:isolation & purification* / Q000627:therapeutic use*; D031407:Crinum / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000627:therapeutic use*; D017495:Hyperpigmentation / Q000188:drug therapy*; D007980:Levodopa / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008543:Melanins / Q000096:biosynthesis; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D018517:Plant Roots / Q000737:chemistry; D011714:Pyrans / Q000302:isolation & purification* / Q000627:therapeutic use*; D011753:Pyrones / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
C530177:6-hydroxy-2H-pyran-3-carbaldehyde; D000447:Aldehydes; D004791:Enzyme Inhibitors; D008543:Melanins; D011714:Pyrans; D011753:Pyrones; D007980:Levodopa; C011890:kojic acid; D014442:Monophenol Monooxygenase