Anti-inflammatory activity of some potassium salts of N,N-disubstituted 4-aminoazobenzenesulfonic acids in rat adjuvant arthritis.
Anti-inflammatory effects of three potassium salts of N,N-disubstituted 4-aminoazobenzenesulfonic acids were investigated and compared to that of acetylsalicylic acid (ASA) in rats with adjuvant arthritis (AA). Prophylactic oral administration of all compounds in a dose of 150 mg/kg ameliorated AA symptoms in animals. The most pronounced anti-inflammatory activity at the end of the experiment showed compound 1 containing imino group: it significantly suppressed joint swelling by 48.2% in female and by 44.2% in male rats with AA. The development of polyarthritis after the treatment with this compound was the lowest in female (20%) and male (40%) rats (in control--100% of animals with polyarthritis). All derivatives, and especially compound 1, also improved the systemic parameters of disease such as blood indices and internal organs' weight, and showed no toxicity on the main organs such as liver and spleen.
Kazemekaite
Maryte
M
Institute of Biochemistry, Mokslininku Street 12, LT-08862, Vilnius, Lithuania. marytek@bchi.lt
Leonaviciene
Laima
L
Bradunaite
Ruta
R
Staniulyte
Zita
Z
Palaima
Algirdas
A
Razumas
Valdemaras
V
D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D001557:Benzenesulfonates / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005620:Freund's Adjuvant; D006403:Hematologic Tests; D007596:Joints / Q000187:drug effects / Q000473:pathology; D008297:Male; D019804:Mesalamine / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D009929:Organ Size; D051381:Rats; D011917:Rats, Inbred Lew
D000893:Anti-Inflammatory Agents; D001557:Benzenesulfonates; D019804:Mesalamine; D005620:Freund's Adjuvant