Anti-inflammatory activity of some potassium salts of N,N-disubstituted 4-aminoazobenzenesulfonic acids in rat adjuvant arthritis.
Anti-inflammatory effects of three potassium salts of N,N-disubstituted 4-aminoazobenzenesulfonic acids were investigated and compared to that of acetylsalicylic acid (ASA) in rats with adjuvant arthritis (AA). Prophylactic oral administration of all compounds in a dose of 150 mg/kg ameliorated AA symptoms in animals. The most pronounced anti-inflammatory activity at the end of the experiment showed compound 1 containing imino group: it significantly suppressed joint swelling by 48.2% in female and by 44.2% in male rats with AA. The development of polyarthritis after the treatment with this compound was the lowest in female (20%) and male (40%) rats (in control--100% of animals with polyarthritis). All derivatives, and especially compound 1, also improved the systemic parameters of disease such as blood indices and internal organs' weight, and showed no toxicity on the main organs such as liver and spleen.
Institute of Biochemistry, Mokslininku Street 12, LT-08862, Vilnius, Lithuania. marytek@bchi.lt
Maryte
M
Kazemekaite
Laima
L
Leonaviciene
Ruta
R
Bradunaite
Zita
Z
Staniulyte
Algirdas
A
Palaima
Valdemaras
V
Razumas
D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D001557:Benzenesulfonates / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005620:Freund's Adjuvant; D006403:Hematologic Tests; D007596:Joints / Q000187:drug effects / Q000473:pathology; D008297:Male; D019804:Mesalamine / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D009929:Organ Size; D051381:Rats; D011917:Rats, Inbred Lew
D000893:Anti-Inflammatory Agents; D001557:Benzenesulfonates; D019804:Mesalamine; D005620:Freund's Adjuvant