In vivo selection of an Escherichia coli isolate highly resistant to ciprofloxacin and ceftazidime: role of a 4-bp duplication in acrR and ampC overexpression.
Stéphane
S
Corvec
Didier
D
Lepelletier
Alain
A
Reynaud
Sandie
S
Dauvergne
Cécile
C
Giraudeau
Nathalie
N
Caroff
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D002442:Ceftazidime / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D011704:Pyelonephritis / Q000188:drug therapy / Q000382:microbiology; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D015854:Up-Regulation; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
C515217:AcrR protein, E coli; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D012097:Repressor Proteins; D002939:Ciprofloxacin; D002442:Ceftazidime; C048795:AmpC beta-lactamases; D001618:beta-Lactamases