Transient responses of continuously growing yeast cultures to dilution rate shifts: a sensitive means to analyze biology and the performance of equipment.
Transient responses of continuously growing yeast cultures to step changes in dilution rate were influenced by (1) the preshift conditions of the culture, (2) the magnitude of the dilution rate increase, (3) the organism involved, and (4) the type of bioreactor used. The sensitivity of transient responses to seemingly minor differences in the design of experiments indicated that this type of investigation may be a means to analyze kinetics of microbial cultures as well as the effectiveness of bioreactors.
Department of Biotechnolgy, Swiss Federal Institute of Technology, ETH Hoenggerberg, 8093 Zurich, Switzerland.
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Kätterer
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Allemann
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Käppeli
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Fiechter