Magnesium and other bivalent cations influence upon sodium montelukast effect in experimental-induced thermoalgesia.
We tested the influence of magnesium, zinc and copper upon the montelukast (MK, antagonist of cysteinyl leukotriene receptor type 1) effect in experimentally-induced thermoalgesia. We worked on 5 groups of 10 adults, each Wistar rats, that received: group I-control; group II: MK (10 mg/kg) unique administration; group III: MgCl2 (1 mM/kg/day) i.p., 3 days and MK (10 mg/kg) unique administration on the 3rd day; group IV: ZnCl2, (0.1 mM/kg/day), i.p., 3 days and MK (10 mg/kg) unique administration on the 3rd day; group V: copper acetate (0.05 mM/kg/day), i.p., 3 days and MK (10 mg/kg) unique administration on the 3rd day. We determined the thermoalgesic sensitivity (TS) using a tail flick analgesia meter, initially, 3 days after daily cation administration and 3 hours after MK administration. Our data show that MK has a statistically significant reduction of TS vs control group (3.76 +/- 1.04 s vs 1.81 +/- 0.98 s, p < 0.05). Copper and magnesium administration do not significantly change the MK effect to decrease TS. The co-administration of zinc and MK statistically significantly increased the TS of the group that received only MK (2.51 +/- 0.21 s vs 3.76 +/- 1.04 s, p < 0.05). Animals that received only cations (in the above mentioned doses) did not significantly change TS.
Nechifor
Mihai
M
Department of Pharmacology, University of Medicine and Pharmacy "Gr.T. Popa", Iasi, Romania. nechifor@umfiasi.ro
Cuciureanu
Magda
M
Chelarescu
Dan
D
Ciubotariu
Diana
D
Pascu
Mihaela
M
D000085:Acetates / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002412:Cations / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D003300:Copper / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D003521:Cyclopropanes; D006358:Hot Temperature; D006930:Hyperalgesia / Q000503:physiopathology / Q000517:prevention & control*; D007274:Injections, Intraperitoneal; D020024:Leukotriene Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D008274:Magnesium / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D008297:Male; D011804:Quinolines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013440:Sulfides; D015032:Zinc / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology
D000085:Acetates; D002412:Cations; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; D003300:Copper; D008274:Magnesium; D015032:Zinc; C093875:montelukast