Synthesis and chiral recognition properties of novel fluorescent chemosensors for amino acid.
The charge neutral chiral optical sensors 1a-d containing thiourea and amide groups were synthesized by simple steps in good yields and their structures were characterized by IR, 1H NMR, 13C NMR, MS spectra and elemental analysis. The enantioselective recognition for alpha-phenylglycine and phenylglycinol was examined by fluorescence emission and UV-vis spectra. The fluorescence and UV-vis spectra changes of 1a were obvious when the enantiomers of alpha-phenylglycine anion were added, which exhibited that 1a has good enantioselective recognition ability towards alpha-phenylglycine.
Department of Chemistry, Wuhan University, Wuhan, Hubei, 430072, People's Republic of China.
Xiao-Huan
XH
Huang
Yong-Bing
YB
He
Chen-Guang
CG
Hu
Zhi-Hong
ZH
Chen
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000596:Amino Acids / Q000032:analysis*; D015374:Biosensing Techniques / Q000379:methods*; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013890:Thiourea / Q000138:chemical synthesis* / Q000737:chemistry
D000577:Amides; D000596:Amino Acids; D005456:Fluorescent Dyes; D013890:Thiourea