Expression and putative functions of GDF-15, a member of the TGF-beta superfamily, in human glioma and glioblastoma cell lines.
Recent studies have demonstrated growth-inhibiting effects of growth differentiation factor-15 (GDF-15) on different cancer cell lines invitro and on tumor growth in vivo. Here, we present data concerning expression of GDF-15 in glioblastoma. We found low levels of GDF-15 transcripts in primary glioblastoma. Thus, GDF-15 expression might be exploited as a useful indicator for distinguishing primary from other glial derived tumors. In contrast to the documented proapoptotic and anti-tumorigenic activities of GDF-15 in several cancer cell lines, our data suggest that GDF-15 does not decrease proliferation of glioblastoma cell lines, while its effects on invasiveness are not consistent.
Department of Neuroanatomy and Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, INF 307, Heidelberg, Germany. jens.strelau@urz.uni-heidelberg.de
Jens
J
Strelau
Corina
C
Schmeer
Heike
H
Peterziel
Tina
T
Sackmann
Christel
C
Herold-Mende
Hans
H
Steiner
Michael
M
Weller
Klaus
K
Unsicker
D017209:Apoptosis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D016207:Cytokines / Q000032:analysis / Q000502:physiology*; D005909:Glioblastoma / Q000737:chemistry / Q000473:pathology*; D005910:Glioma / Q000737:chemistry / Q000473:pathology*; D055436:Growth Differentiation Factor 15; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D016207:Cytokines; C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15; D016159:Tumor Suppressor Protein p53