DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients.
Dysbindin gene (DTNBP1) has been associated with schizophrenia, but literature findings are inconsistent, and further analyses are required. This study is aimed to investigate if a set of DTNBP1 variations might influence clinic psychotic phenotype or treatment response in a sample of 240 Korean schizophrenic in-patients. Four variants have been selected (rs3213207; rs1011313; rs16876759; rs2619522) on the basis of previous findings of association with schizophrenia, bipolar disorder and antidepressant response. Single marker analysis gave marginal results. Haplotype analysis identified a significant association between A-A (rs3213207(A/G), rs1011313(A/G)) haplotype and lower PANSS total and positive scores at baseline (p=0.01; 0.02) and at discharge (p=0.008; 0.005). Covariate analysis revealed a more stable significant association between A-A haplotype and baseline scores. These results suggest a protective effect of A-A haplotype on psychotic positive symptoms at baseline.
Pae
Chi-Un
CU
Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, South Korea. pae@catholic.ac.kr
Drago
Antonio
A
Kim
Jung-Jin
JJ
Patkar
Ashwin A
AA
Jun
Tae-Youn
TY
Lee
Chul
C
Mandelli
Laura
L
De Ronchi
Diana
D
Paik
In-Ho
IH
Serretti
Alessandro
A
D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics / Q000473:pathology; D002352:Carrier Proteins / Q000235:genetics*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007723:Korea; D015810:Linkage Disequilibrium; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology
D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins