A direct and versatile access to alpha,alpha-disubstituted 2-pyrrolidinylmethanols by SmI2-mediated reductive coupling.
Various alpha,alpha-disubstituted 2-pyrrolidinylmethanols are efficiently prepared in a single step from ketones using a SmI2-mediated cross-coupling with 1-pyrroline N-oxide. The N-hydroxy-alpha,alpha-diphenylprolinol is also easily prepared and resolved.
Burchak
Olga N
ON
Département de Chimie Moléculaire (SERCO) UMR, CNRS-Université Joseph Fourier, Grenoble Cedex, France.
Philouze
Christian
C
Chavant
Pierre Yves
PY
Py
Sandrine
S