Interaction between methylenetetrahydrofolate reductase C677T gene polymorphism and sleep duration on risk of stroke pathogenesis.
OBJECTIVE
To investigate the interaction between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and sleeping duration on risk of stroke in a Chinese Han ethnic population.


METHODS
In the case-control study and epidemiological investigation, the self-reported sleep duration and MTHFR C677T polymorphism of 245 patients with cerebral infarction, 222 patients with cerebral hemorrhage and 282 controls were collected. Multiple logistic regression was performed to analyze the interaction between MTHFR C677T polymorphism and sleeping duration on risk of stroke.


RESULTS
After adjustment for major confounding variables, multiple logistic regression analysis showed that: (1) There was significant association between long sleep duration (>8 hours of sleep per night) and cerebral infarction (OR=3.90; 95% CI: 2.43-6.26), but not for cerebral hemorrhage (OR=1.16, 95% CI: 0.71-1.92). On the other hand, insomnia (sleep duration less than 6 hours) was neither associated with cerebral infarction nor hemorrhage. (2) MTHFR TT genotype increased the risk of cerebral infarction significantly (OR=2.01; 95% CI: 1.12-3.61), but not for cerebral hemorrhage (OR=1.16, 95% CI: 0.71-1.92). (3)There was a significant synergistic effect of interaction between MTHFR TT677 genotype and long sleep duration on risk of cerebral infarction (OR=6.22; 95% CI: 2.44-15.83).


CONCLUSIONS
MTHFR TT677 genotype and long sleep duration increase the risk of cerebral infarction independent of confounding factors, respectively. Furthermore, there is a significant synergistic effect between MTHFR TT677 genotype and long sleep duration on risk of cerebral infarction in the Chinese Han ethnic population.
Zhang
Yan
Y
Department of Neurology, Peking University Third Hospital, Beijing, China.
Xie
Ru Ping
RP
Shen
Yang
Y
Fan
Dong Sheng
DS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D002543:Cerebral Hemorrhage / Q000201:enzymology / Q000235:genetics / Q000503:physiopathology; D002544:Cerebral Infarction / Q000201:enzymology / Q000235:genetics / Q000503:physiopathology; D002681:China / Q000208:ethnology; D005260:Female; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012890:Sleep / Q000502:physiology*; D020521:Stroke / Q000201:enzymology* / Q000235:genetics / Q000503:physiopathology; D013997:Time Factors
D042965:Methylenetetrahydrofolate Reductase (NADPH2)