Abducent nerve paralysis: first clinical sign of clivus metastasis from tonsillar carcinoma.
It is known that 15-20% of oropharyngeal carcinomas develop distant metastases that involve most commonly lung, liver and bone. Clival metastasis from oropharyngeal squamous cell carcinoma has not been previously reported in the English literature. We describe the rare occurrence of clival metastasis from tonsillar carcinoma presenting with abducent paralysis and discuss diagnostic and therapeutic rational approaches. Despite neoadjuvant chemotherapy (cisplatinum/etoposide/epirubicin followed by taxotere), extended left tonsillectomy and ipsilateral radical neck dissection and external radiotherapy (60 Gy) for tonsillar carcinoma, the patient developed clival metastasis and died of disease. The overall prognosis of patients with clival metastases is extremely poor, with an overall median survival of about 2.5 years. Cranial nerve palsy occurrence is associated with a poorer prognosis with an average survival of only 5 months.
Marchese-Ragona
Rosario
R
Department of Medical and Surgical Specialties, Section of Otolaryngology. rmr@unipd.it
Maria Ferraro
Silvia
S
Marioni
Gino
G
Staffieri
Claudia
C
Manara
Renzo
R
Restivo
Domenico A
DA
Staffieri
Alberto
A
D020434:Abducens Nerve Diseases / Q000209:etiology*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000175:diagnosis / Q000556:secondary*; D003388:Cranial Fossa, Posterior; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019292:Skull Base Neoplasms / Q000150:complications / Q000175:diagnosis / Q000556:secondary*; D014067:Tonsillar Neoplasms / Q000473:pathology*