Deletion of chromosome arm 15q in a case of minimally differentiated hypoplastic AML-M0.
Deletion of the long arm of chromosome 15 is known as a rare but recurrent chromosomal abnormality in myeloid malignancies. We report a novel case of minimally differentiated hypoplastic acute myeloid leukemia (AML M0) in a patient who initially had a normal karyotype, but clonal interstitial deletion of chromosome 15, del(15)(q11.2q22), coincided with increment of leukemic cells a year later. We also summarize 18 published cases with myeloid malignancies and this chromosomal abnormality.
Fujieda
Atsushi
A
Department of Hematology and Oncology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507 Japan.
Masuya
Masahiro
M
Kitano
Shigehisa
S
Miyazaki
Kana
K
Yazaki
Akira
A
Sugimoto
Yuka
Y
Usui
Eiji
E
Miyata
Eri
E
Shibasaki
Tetsunori
T
Yamamura
Kentaro
K
Ohishi
Kohshi
K
Nishii
Kazuhiro
K
Nakase
Kazunori
K
Takeuchi
Toshiaki
T
Katayama
Naoyuki
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002454:Cell Differentiation; D002872:Chromosome Deletion; D002884:Chromosomes, Human, Pair 15; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012008:Recurrence