Behavioral symptoms after pallido-nigral lesions: a clinico-pathological case.
A 59-year-old patient presented with compulsive behaviors and lasting apathy after carbon monoxide intoxication. The apathy could be overcome by external stimulation (self-activation deficit). There was severe neuronal loss bilaterally in the anterior part of the pallidum and in the substantia nigra, pars reticulata. This first clinico-pathological case of a self-activation deficit illustrates the dissociation between motor and behavioral symptoms in lesions of the pallido-nigral complex, with the behavioral symptoms being related to lesions of the substantia nigra, pars reticulata and of the anterior part of the pallidum.
Adam
Julien
J
Raymond Escourolle Neuropathology Laboratory, Hopital de La Salpetriere, Inserm U679, APHP, Pierre et Marie Curie Paris VI University, Paris, France.
Baulac
Michel
M
Hauw
Jean-Jacques
JJ
Laplane
Dominique
D
Duyckaerts
Charles
C
D000342:Affective Symptoms / Q000188:drug therapy / Q000209:etiology*; D001154:Art; D001284:Atrophy; D001921:Brain / Q000473:pathology; D002114:Calcinosis / Q000150:complications / Q000000981:diagnostic imaging; D002249:Carbon Monoxide Poisoning / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000523:psychology*; D002908:Chronic Disease; D003192:Compulsive Behavior / Q000209:etiology* / Q000523:psychology; D004298:Dopamine / Q000627:therapeutic use; D005917:Globus Pallidus / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D013378:Substantia Nigra / Q000473:pathology*; D014057:Tomography, X-Ray Computed
D004298:Dopamine