Cyclin D1 (G870A) polymorphism and risk of cervix cancer: a case control study in north Indian population.
Cyclin D1 (CCND1) is a key regulatory protein, playing a critical role in the transition from G1 to S phase of the cell cycle. We have evaluated the association between CCND1 A870G polymorphism and risk of cervix cancer in north Indian women by using PCR-RFLP method. This association was estimated by computing odds ratio (ORs) and a 95% Confidence Intervals (95% CI) using a Multivariate Logistic Regression Analysis. No significant association was observed between CCND1 genotypes and overall risk of cervix cancer. But when stratified histologically, statistically significant (OR: 3.7, 95% CI: 1.56-8.87, P: 0.001) increased risk of squamous cell carcinoma (SCC) was observed for individuals with AA genotype. Thus our findings suggest that CCND1 (G870A) polymorphism may be associated with increased risk of SCC of the uterine cervix in north Indian women.
Satinder
Kaur
K
Department of Biotechnology, Panjab University, Chandigarh, India. satinder_77@yahoo.co.in
Chander
Sobti Ranbir
SR
Pushpinder
Kaur
K
Indu
Gupta
G
Veena
Jain
J
D016022:Case-Control Studies; D016001:Confidence Intervals; D003296:Cooking; D019938:Cyclin D1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007194:India; D008875:Middle Aged; D016017:Odds Ratio; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects; D002583:Uterine Cervical Neoplasms / Q000235:genetics*; D014934:Wood
D014028:Tobacco Smoke Pollution; D019938:Cyclin D1