Synovial sarcoma of the neck in a child: a multidisciplinary approach.
Synovial sarcoma (SS) is the most common nonrhabdomyosarcomatous soft tissue sarcoma in childhood, but the head-neck site accounts for less than 5% of cases. The authors report a 10-year-old boy with SYT-SSX1 positive left parapharyngeal SS, resistant to front-line VAIA chemotherapy, who obtained a good partial response by salvage regimen (I(3)VE + CEV + I(3)VE) and local radiotherapy, so a complete surgical resection could be performed. The complete remission was subsequently consolidated by ablative high-dose chemotherapy, followed by autologous stem cell reinfusion. The child remains in complete remission at 36 months after completion of treatment.
Farruggia
Piero
P
Pediatric Hematology Oncology, Ospedale dei Bambini "G. Di Cristina", Palermo, Italy.
D'Angelo
Paolo
P
Lo Cascio
Manlio
M
Solazzo
Luigi
L
Montemaggi
Paolo
P
Novara
Vincenzo
V
Alaggio
Rita
R
Rosolen
Angelo
A
Caselli
Desiree
D
Arico
Maurizio
M
D002648:Child; D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008297:Male; D012074:Remission Induction / Q000379:methods; D016879:Salvage Therapy / Q000379:methods; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000628:therapy