Protective effects of a PPARgamma agonist pioglitazone on anti-oxidative system in testis of diabetic rabbits.
In the present study, modulation of oxidative stress by pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, was examined in testis of alloxan-induced diabetic rabbits. In diabetic animals, an increase in the activity of anti-oxidative enzymes: superoxide dismutase (Cu,Zn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GSSG-R), and in the level of glutathione (GSH) but a decrease in the level of ascorbic acid (AA) were observed. These effects were accompanied by a significant increase in testicular lipid and protein oxidation. Pioglitazone affected the activity of Cu,Zn-SOD, normalized the activity of CAT, the level of AA as well as the levels of LPO and PCG without having any significant effect on blood glucose level.
Gumieniczek
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Department of Medicinal Chemistry, Medical University of Lublin, Poland. anna.gumieniczek@am.lublin.pl
Hopkała
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Zabek
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D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D047495:PPAR gamma / Q000819:agonists*; D000077205:Pioglitazone; D011817:Rabbits; D013737:Testis / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D045162:Thiazolidinediones / Q000494:pharmacology*
D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D047495:PPAR gamma; D045162:Thiazolidinediones; D005978:Glutathione; D001205:Ascorbic Acid; D000077205:Pioglitazone