8-Amino guanine accelerates tetramolecular G-quadruplex formation.
We demonstrate here that 8-amino guanine () strongly accelerates quadruplex formation, which makes this nucleobase the most attractive replacement for guanine in the context of tetramolecular parallel quadruplexes.
Gros
Julien
J
Muséum National d'Histoire Naturelle (MNHN) USM 503, INSERM U565, CRNS UMR 5153, 43 rue Cuvier CP26, F-75231, Paris Cedex 05, France.
Aviñó
Anna
A
Lopez de la Osa
Jaime
J
González
Carlos
C
Lacroix
Laurent
L
Pérez
Alberto
A
Orozco
Modesto
M
Eritja
Ramon
R
Mergny
Jean-Louis
JL
D001483:Base Sequence; D002942:Circular Dichroism; D054856:G-Quadruplexes; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D013696:Temperature
C033495:8-aminoguanine; D006147:Guanine