Virtual high throughput screening (vHTS) on an optical high speed testbed.
Malaria remains a global health concern, which kills over a million people each year. In this paper we present work extending the approach of the WISDOM initiative by focusing on the problems noticed during the first WISDOM challenge against malaria and test the newly established, high bandwidth optical Grid environment VIOLA for advanced bioinformatics applications using the UNICORE middleware service. In addition we present an approach to reduce the size of the compound database to improve the efficiency of the screening.
Shahid
Mohammad
M
Fraunhofer Institute SCAI, Department of Bioinformatics, Germany.
Ziegler
Wolfgang
W
Kasam
Vinod
V
Zimmermann
Marc
M
Hofmann-Apitius
Martin
M
D019295:Computational Biology / Q000458:organization & administration*; D003199:Computer Systems; D019992:Databases as Topic; D005858:Germany; D006801:Humans; D008288:Malaria; D008492:Medical Informatics Computing; D014584:User-Computer Interface