Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses.
Cytokine gene polymorphisms affect vaccine responses and gender-specific effects are known for many phenotypes. Therefore, this study investigated gender-specific effects of cytokine gene polymorphisms on vaccine responses. In 263 2-year-old subjects selected for parental history of atopy, boys with IL-4 C-589T and IL-4Ralpha I50V genotypes associated with atopy had increased Diptheria Toxoid (DiphTox) and Tetanus Toxoid (TetTox) responses compared with the remaining alleles (IL-4 C-589T: DipTox p=0.01, TetTox p=0.04; IL-4Ralpha.I50V: DipTox p=0.04, TetTox p=0.08). Contrastingly, girls with IL-10 -592C genotypes associated with atopy had lower levels of DiphTox (p=0.03) and TetTox (p=0.02) responses compared with the remaining allele. Additionally, interaction effects were found for IL-4 C-589T (p=0.01) and IL-4Ralpha I50V (p=0.04) polymorphisms. In conclusion, these findings support the interaction of primary genetic and modifying factors on vaccine responses and the importance of atopic genetics to these responses.
Baynam
Gareth
G
Telethon Institute for Child Health Research and Centre for Child Health Research, Perth, Australia. gareth.baynam@health.wa.gov.au
Zhang
Guicheng
G
Khoo
Siew-Kim
SK
Sly
Peter
P
Holt
Patrick
P
Goldblatt
Jack
J
Le Souëf
Peter N
PN
D000907:Antibodies, Bacterial / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D001428:Bacterial Vaccines / Q000276:immunology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D016753:Interleukin-10 / Q000235:genetics; D015847:Interleukin-4 / Q000235:genetics; D008297:Male; D011110:Polymorphism, Genetic; D012727:Sex Characteristics; D014765:Viral Vaccines / Q000276:immunology*
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D014765:Viral Vaccines; D016753:Interleukin-10; D015847:Interleukin-4