Effect of milk tripeptides on blood pressure: a meta-analysis of randomized controlled trials.
OBJECTIVE
To better understand and summarize the relation between milk peptide intake and blood pressure (BP), we conducted a meta-analysis of randomized controlled trials to assess the effects of the milk-derived tripeptides isoleucine-proline-proline and valine-proline-proline on BP in prehypertensive and hypertensive subjects.


METHODS
Nine studies including 12 trials published between 1996 and 2005 with a total of 623 participants were included. Two researchers independently extracted data from the original publications. A fixed-effects model was used for meta-analysis because of the homogeneity among trials.


RESULTS
Significant decreases of 4.8 mmHg (95% confidence interval 3.7-6.0) in systolic BP and 2.2 mmHg (95% confidence interval 1.3-3.1) in diastolic BP were found after the pooling of these trials. When trials were separated by BP status, hypotensive effects appeared to be larger in hypertensive subjects than in prehypertensive subjects. As a trend, the hypotensive effects became more obvious as the intervention lengthened.


CONCLUSIONS
Our analysis provided evidence that milk-derived tripeptides have hypotensive effects in prehypertensive and hypertensive subjects.
School of Radiation Medicine and Public Health, Soochow University, Suzhou, China.
Jia-Ying
JY
Xu
Li-Qiang
LQ
Qin
Pei-Yu
PY
Wang
Wei
W
Li
Chun
C
Chang
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D003971:Diastole; D005260:Female; D006801:Humans; D006973:Hypertension / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D008894:Milk Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D016032:Randomized Controlled Trials as Topic; D013599:Systole; D013997:Time Factors; D016896:Treatment Outcome
D008894:Milk Proteins