Regulation of TNFR1 and CD95 signalling by receptor compartmentalization.
The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as FAS and APO-1) transduce signals that promote cell death by apoptosis. However, these receptors are also capable of inducing anti-apoptotic signals through the activation of the transcription factor nuclear factor-kappaB (NF-kappaB) or through activation of the proliferative mitogen-activated protein kinase (MAPK) cascade. Recent findings reveal a role for receptor internalization and endosomal trafficking in selectively transmitting the signals that lead either to apoptosis or to the survival of the cell.
Schütze
Stefan
S
Institute of Immunology, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany. schuetze@immunologie.uni-kiel.de
Tchikov
Vladimir
V
Schneider-Brachert
Wulf
W
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002451:Cell Compartmentation / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D021381:Protein Transport / Q000502:physiology; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D019014:fas Receptor / Q000378:metabolism* / Q000502:physiology
D047888:Receptors, Tumor Necrosis Factor, Type I; D019014:fas Receptor