Integrins put the brakes on microcluster dynamics at the immunological synapse.
Integrin engagement costimulates T cell receptor signaling, but the underlying mechanisms are poorly understood. In this issue of Immunity, Nguyen et al. (2008) show that engagement of VLA-4 promotes sustained signaling by altering the dynamics of actin filaments and signaling molecules at the immunological synapse.
Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. jburkhar@mail.med.upenn.edu
Janis K
JK
Burkhardt
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D017951:Antigen Presentation; D006801:Humans; D039041:Integrin alpha4beta1 / Q000378:metabolism*; D008213:Lymphocyte Activation; D010750:Phosphoproteins / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D039041:Integrin alpha4beta1; D010750:Phosphoproteins; D011948:Receptors, Antigen, T-Cell; C092947:SLP-76 signal Transducing adaptor proteins