The role of calmodulin kinase II in myocardial physiology and disease.
The multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) regulates a rich variety of downstream targets in heart. Ca(2+) homeostatic proteins are important CaMKII targets that support myocardial excitation-contraction coupling. Under stress conditions, excessive CaMKII activity promotes heart failure and arrhythmias, in part through actions at Ca(2+) homeostatic proteins. Here, we briefly review the molecular and cellular physiology of CaMKII in myocardium.
Departments of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Carver College of Medicine, Iowa City, Iowa, USA.
Luis F
LF
Couchonnal
Mark E
ME
Anderson
D000595:Amino Acid Sequence; D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism*; D006331:Heart Diseases / Q000201:enzymology*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008969:Molecular Sequence Data; D009206:Myocardium / Q000201:enzymology*; D015398:Signal Transduction / Q000502:physiology
D007527:Isoenzymes; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2