[Clinical case of the month. Antibiotics and hemodialysis: three cases of neurotoxicity from Maxipime].
The metabolism of drugs is altered in dialysed patients. We report three clinical cases of neurological toxicity from cefepime in dialysed patient. This molecule can induce in renal insufficiency patients various reversible neurological manifestations like metabolic encephalopathy, myoclonies, or a state of status epilepticus that mimics sometimes a coma in spite of adequate dosing.
ervice de Néphrologie, CHU Sart Tilman, Liège, Belgique.
M C
MC
Parotte
J M
JM
Krzesinski
D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology; D001927:Brain Diseases / Q000139:chemically induced* / Q000628:therapy; D000077723:Cefepime; D002511:Cephalosporins / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000077723:Cefepime