Diffuse cerebral infarct associated with factor V Leiden and prothrombin 20210A mutations in a patient with tetralogy of Fallot.
A 2-year-old girl with tetralogy of Fallot presented with diffuse cranial infarct after cardiac angiography. Heterozygosity for factor V Leiden and prothrombin 20210A mutations were detected. The authors suggest that if thrombosis develops in patients with congenital heart disease, genetic risk factors should be evaluated.
Department of Pediatric Hematology, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey. tansusipahi@hotmail.com
Tansu
T
Sipahi
Selmin
S
Karademir
Ayça
A
Kuybulu
Nejat
N
Akar
D002675:Child, Preschool; D005165:Factor V / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006495:Heparin, Low-Molecular-Weight; D006801:Humans; D009154:Mutation; D011516:Prothrombin / Q000235:genetics; D020521:Stroke / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D013771:Tetralogy of Fallot / Q000150:complications*; D014859:Warfarin
D006495:Heparin, Low-Molecular-Weight; C095381:factor V Leiden; D014859:Warfarin; D005165:Factor V; D011516:Prothrombin