The effect of hydrophilic base on pharmaceutical availability of prednisolone complexed with beta-cyclodextrin.
Studies on the effect of hydrophilic gel composition on pharmaceutical availability of prednisolone complexed with beta-cyklodextrin at P:beta-CD ratios 1:1 and 1:2 revealed that the half-release times were shortened and differentiated depending on the substances added hydrogel to propylene glycol, dimethylacetamide and polysorbate 20 in comparison to preparations containing non-complexed active substance.
Department of Pharmaceutical Technology, Wrocław Medical University. szczesniak@gmail.com
Maria
M
Szcześniak
Aleksander A
AA
Kubis
Janusz
J
Pluta
D000081:Acetamides / Q000737:chemistry; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics*; D001682:Biological Availability; D005782:Gels / Q000737:chemistry; D020100:Hydrogels / Q000493:pharmacokinetics; D014677:Pharmaceutical Vehicles / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D011239:Prednisolone / Q000493:pharmacokinetics*; D019946:Propylene Glycol / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000493:pharmacokinetics*
D000081:Acetamides; D000893:Anti-Inflammatory Agents; D005782:Gels; D020100:Hydrogels; D014677:Pharmaceutical Vehicles; D011136:Polysorbates; D047392:beta-Cyclodextrins; D019946:Propylene Glycol; D011239:Prednisolone; C013959:dimethylacetamide; C031215:betadex