Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring.
Children of parents with hypertension are at increased risk of developing high blood pressure. We hypothesize that circulating concentrations of putative biomarkers (that may play a role in development of high blood pressure) are higher in nonhypertensive offspring of parents with hypertension. We compared concentrations of 4 different biomarkers (urinary albumin:creatinine ratio, circulating C-reactive protein, aldosterone:renin ratio, and plasminogen activator inhibitor-1) in nonhypertensive Framingham offspring study participants with none (n=233), 1 (n=474), or both (n=322) parents with hypertension. Parental hypertension was defined as onset before age 60 years, based on longitudinal observations of the original Framingham cohort. Serum C-reactive protein concentrations were higher in nonhypertensive offspring with 1 (median: 1.7; Q1 to Q3: 0.8 to 3.6 mg/L) or both parents with hypertension (median: 1.8; Q1 to Q3: 0.7 to 3.6 mg/L) compared with offspring without parental hypertension (median: 1.4; Q1 to Q3: 0.7 to 3.2 mg/L). In multivariable analyses, parental hypertension was associated with higher serum C-reactive protein concentration in offspring (15% increase per parent with hypertension; P=0.004). Prospectively, the relation of parental hypertension to longitudinal changes in blood pressure in the nonhypertensive offspring was attenuated on adjustment for C-reactive protein (P=0.04 for attenuation). The levels of the other biomarkers evaluated did not significantly differ in offspring according to parental hypertension status. In conclusion, serum C-reactive protein concentrations are higher in nonhypertensive offspring of parents with hypertension. These data suggest that inflammation may partly mediate the familial influences on hypertension risk.
Lieb
Wolfgang
W
Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702-5803, USA.
Pencina
Michael J
MJ
Wang
Thomas J
TJ
Larson
Martin G
MG
Lanier
Katherine J
KJ
Benjamin
Emelia J
EJ
Levy
Daniel
D
Tofler
Geoffrey H
GH
Meigs
James B
JB
Newton-Cheh
Christopher
C
Vasan
Ramachandran S
RS
D000328:Adult; D032721:Adult Children; D000368:Aged; D000418:Albumins / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis*; D001794:Blood Pressure / Q000235:genetics; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D018392:Genomic Imprinting; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012083:Renin / Q000378:metabolism; D018570:Risk Assessment
D000418:Albumins; D015415:Biomarkers; D002097:C-Reactive Protein; D003404:Creatinine; D012083:Renin