Mixed-type liposarcoma: clinicopathological, immunohistochemical, and molecular analysis of a case arising in deep soft tissues of the lower extremity.
A rare case of mixed-type liposarcoma arising in deep soft tissue of the right thigh of a 45-year-old female patient is reported. The neoplasm was completely excised and was composed of an irregular admixture of areas of atypical lipomatous tumor/well-differentiated liposarcoma of the lipoma-like subtype with areas of myxoid/round cell liposarcoma. An amplification of the MDM2 and CDK4 genes respectively in the atypical lipomatous tumor/well-differentiated liposarcoma areas was detected by fluorescence in situ hybridization (FISH) analysis, and translocations of the CHOP and FUS genes were detected by FISH analysis in the myxoid/round cell liposarcoma areas.
Mentzel
Thomas
T
Dermatopathologische Gemeinschaftspraxis, Siemensstrasse 6/1, 88048, Friedrichshafen, Germany. mentzel@dermpath.de
Palmedo
Gabriele
G
Hantschke
Markus
M
Woziwodzki
Jörg
J
Beck
Christian
C
D051358:Cyclin-Dependent Kinase 4 / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008080:Liposarcoma / Q000737:chemistry / Q000473:pathology*; D018208:Liposarcoma, Myxoid / Q000737:chemistry / Q000473:pathology*; D008875:Middle Aged; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism; D034702:RNA-Binding Protein FUS / Q000235:genetics; D013848:Thigh; D051742:Transcription Factor CHOP / Q000235:genetics; D014178:Translocation, Genetic
C497249:DDIT3 protein, human; D034702:RNA-Binding Protein FUS; D051742:Transcription Factor CHOP; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; C495900:CDK4 protein, human; D051358:Cyclin-Dependent Kinase 4