Insight into the mechanism of the acquired antibody auto-reactivity.
A fraction of antibodies present in all healthy individuals begins to recognize large number of self-antigens only after a transient exposure to certain protein-destabilizing conditions, including low or high pH, high salt concentration, chaotropic factors and redox-active agents. Recent findings on the molecular mechanisms of the inducible antibody auto-reactivity, obtained by using kinetic and thermodynamic analysis on the interactions of single monoclonal antibody with its cognate antigen are discussed in the review.
Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Paris 6, UMRS 872, Paris, F-75006 France. Jordan.Dimitrov@crc.jussieu.fr
Jordan D
JD
Dimitrov
Sebastien
S
Lacroix-Desmazes
Srinivas V
SV
Kaveri
Tchavdar L
TL
Vassilev
D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D001323:Autoantibodies / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007700:Kinetics; D013816:Thermodynamics
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D007074:Immunoglobulin G