[The interaction between anticoagulant therapy with vitamin K-antagonists and treatment with antibiotics: a practical recommendation].
--In users of vitamin K-antagonists (VKA), antibiotics can lead to excessive anticoagulation. --It is unclear what the optimal policy is for prevention of an excessive anticoagulant effect during use of antibiotics. --This article describes the increased sensitivity to VKA during use of antibiotics, and also provides a practical recommendation for the correct method for use of antibiotics in combination with VKA treatment. --During use of antibiotics for more than one day, the prothrombin time-'international normalized ratio' (PTT-INR) must be checked both after 3 and after 7 days, and the dose of VKA must be adapted if necessary. --Use of co-trimoxazole for more than one day should, if possible, be avoided.
VU Medisch Centrum, Amsterdam.
M
M
Zelis
S
S
Zweegman
F J M
FJ
van der Meer
M H H
MH
Kramer
Y M
YM
Smulders
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000925:Anticoagulants / Q000627:therapeutic use*; D004347:Drug Interactions; D006470:Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D019934:International Normalized Ratio; D012307:Risk Factors; D014812:Vitamin K / Q000037:antagonists & inhibitors*
D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D014812:Vitamin K