[Phagocytic functional and metabolic activities in the interaction with F. tularensis subspecies of various virulence].
There is evidence that the facultatively intracellular pathogen affects the functional capacity of phagocytes, which is associated with their bactericidal against a tularemic microbe with varying phenotypic properties. The tularemic microbe of the subspecies Francisella subsp. tularensis and F. tularensis subsp. mediaasiatica is shown to influence the phagocytic capacity of immunocompetent cells, resulting in incomplete phagocytosis. This is corroborated by the lower functional activity of neutrophils and macrophages in the interaction with tularemic microbe of the subspecies tularensis and mediaasiatica to a greater extent than in that with the representatives of other studied F. tularensis subspecies. The low content of cationic protein and the suppressed activity of NO-synthase may be associated with the loss of activity of the enzyme and cationic protein during phagocytosis of the tularemic microbe. The findings are of prognostic value in characterizing the severity of a pathological process caused by F. tularensis and in designing diagnostic and prophylactic agents.
Dubrovina
V I
VI
Tatarnikov
S A
SA
Konovalova
Zh A
ZhA
Mazepa
A V
AV
Vitiazeva
S A
SA
Bel'kov
A I
AI
Shkaruba
T T
TT
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D005604:Francisella tularensis / Q000145:classification / Q000472:pathogenicity*; D006168:Guinea Pigs; D017737:Macrophages, Peritoneal / Q000276:immunology / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D010587:Phagocytosis; D014406:Tularemia / Q000276:immunology* / Q000378:metabolism*; D014774:Virulence
D023181:Antimicrobial Cationic Peptides; D019001:Nitric Oxide Synthase