Modulatory effects of Cissus quadrangularis on periodontal regeneration by bovine-derived hydroxyapatite in intrabony defects: exploratory clinical trial.
OBJECTIVE
The purpose of the present study was to clinically evaluate the efficacy of bovine-derived hydroxyapatite (HA) combined with Cissus quadrangularis (CQ), as compared to bovine-derived hydroxyapatite alone in the treatment of intrabony defects.


METHODS
Twenty patients with one intrabony defect each were selected for this study. After scaling and root planing, twenty sites were randomly selected to receive either a combination of bovine-derived HA and CQ (test group) or bovine-derived HA alone (control group). Baseline and 6-month surgical reentry measurements were taken and appropriate statistical analysis was performed.


RESULTS
Favorable clinical results for both hard and soft tissue measurements were obtained for both groups when compared to baseline (p < 0.001), but there was no statistically significant difference for any of the measured clinical parameters between the two groups. The mean bone fill and percentage bone fill for bovine-derived HA was 2.7 +/- 0.82 mm and 63.2 +/- 17.8%, whereas for composite graft material it was 3.3 +/- 0.82 mm and 69.8 +/- 14.2%.


CONCLUSIONS
Although composite graft material has shown a trend towards better performance, no statistically significant intergroup difference was found. Further studies are needed to establish CQ as a modulator in periodontal regenerative therapy.
Jain
Anurag
A
Department of Periodontics, King George's University of Dental Sciences, Lucknow, India. dranuragjain77@yahoo.co.in
Dixit
Jaya
J
Prakash
Dhan
D
D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery*; D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D032422:Cissus; D003131:Combined Modality Therapy; D012534:Dental Scaling; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D010514:Periodontal Pocket / Q000601:surgery; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018547:Plant Stems; D016745:Root Planing; D016896:Treatment Outcome
D001672:Biocompatible Materials; D018786:Bone Substitutes; D010936:Plant Extracts; D017886:Durapatite