A prototype instrument for single pinhole small animal adaptive SPECT imaging.
The authors have designed and constructed a small-animal adaptive SPECT imaging system as a prototype for quantifying the potential benefit of adaptive SPECT imaging over the traditional fixed geometry approach. The optical design of the system is based on filling the detector with the region of interest for each viewing angle, maximizing the sensitivity, and optimizing the resolution in the projection images. Additional feedback rules for determining the optimal geometry of the system can be easily added to the existing control software. Preliminary data have been taken of a phantom with a small, hot, offset lesion in a flat background in both adaptive and fixed geometry modes. Comparison of the predicted system behavior with the actual system behavior is presented, along with recommendations for system improvements.
U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Building 62, Room 3133, Silver Spring, Maryland 20993-0002, USA. melanie.freed@fda.hhs.gov
Melanie
M
Freed
Matthew A
MA
Kupinski
Lars R
LR
Furenlid
Donald W
DW
Wilson
Harrison H
HH
Barrett
D000465:Algorithms; D000818:Animals; D003201:Computers; D004867:Equipment Design; D006801:Humans; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software; D014055:Tomography, Emission-Computed / Q000379:methods; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation* / Q000379:methods*