Cyclic Disulfides as Functional Mimics of the Histone Deacetylase Inhibitor FK-228.
FK-228 is a potent histone deacetylase (HDAC) inhibitor with tremendous therapeutic potential against a wide array of human cancers. We describe the development of analogs that share FK-228's novel mechanism of activation and HDAC inhibition.
Mays
Jared R
JR
School of Pharmacy, University of Wisconsin, Madison, WI 53705.
Restituyo
José A
JA
Katzenberger
Rebeccah J
RJ
Wassarman
David A
DA
Rajski
Scott R
SR