Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats.
Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.
Kaya
Ahmet H
AH
Department of Neurosurgery, Ondokuz Mayis University, Samsun, Turkey.
Vlamings
Rinske
R
Tan
Sonny
S
Lim
Lee Wei
LW
Magill
Peter J
PJ
Steinbusch
Harry W M
HW
Visser-Vandewalle
Veerle
V
Sharp
Trevor
T
Temel
Yasin
Y
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D003714:Denervation; D004298:Dopamine / Q000172:deficiency; D003576:Electron Transport Complex IV / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology; D008297:Male; D008636:Mesencephalon / Q000166:cytology / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D016627:Oxidopamine; D020734:Parkinsonian Disorders / Q000503:physiopathology*; D011903:Raphe Nuclei / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism; D013565:Sympatholytics; D009435:Synaptic Transmission / Q000502:physiology; D015854:Up-Regulation / Q000502:physiology
D013565:Sympatholytics; D012701:Serotonin; D016627:Oxidopamine; D003576:Electron Transport Complex IV; D004298:Dopamine