Urinary dysfunction after rectal cancer treatment is mainly caused by surgery.
BACKGROUND
Urinary dysfunction (UD) is common after rectal cancer treatment, but the contribution of each treatment component (surgery and radiotherapy) to its development remains unclear. This study aimed to evaluate UD during 5 years after total mesorectal excision (TME) and to investigate the influence of preoperative radiotherapy (PRT) and surgical factors.


METHODS
Patients with operable rectal cancer were randomized to TME with or without PRT. Questionnaires concerning UD were completed by 785 patients before and at several time points after surgery. Possible risk factors, including PRT, demographics, tumour location, and type and extent of resection, were investigated by multivariable regression analysis.


RESULTS
Long-term incontinence was reported by 38.1 per cent of patients, of whom 72.0 per cent had normal preoperative function. Preoperative incontinence (relative risk (RR) 2.75, P = 0.001) and female sex (RR 2.77, P < 0.001) were independent risk factors. Long-term difficulty in bladder emptying was reported by 30.6 per cent of patients, of whom 65.0 per cent had normal preoperative function. Preoperative difficulty in bladder emptying (RR 2.94, P < 0.001), peroperative blood loss (RR 1.73, P = 0.028) and autonomic nerve damage (RR 2.82, P = 0.024) were independent risk factors. PRT was not associated with UD.


CONCLUSIONS
UD is a significant clinical problem after rectal cancer treatment and is not related to PRT, but rather to surgical nerve damage.
Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands.
M M
MM
Lange
C P
CP
Maas
C A M
CA
Marijnen
T
T
Wiggers
H J
HJ
Rutten
E Klein
EK
Kranenbarg
C J H
CJ
van de Velde
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007431:Intraoperative Complications / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012004:Rectal Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D012007:Rectum / Q000601:surgery*; D016896:Treatment Outcome; D014551:Urinary Tract / Q000293:injuries / Q000294:innervation*; D014555:Urination Disorders / Q000209:etiology*