Antibody responses to Cryptosporidium antigen in HIV-positive patients in the Republic of Korea.
The diagnosis of cryptosporidiosis has been carried out using coprologic techniques in the Republic of Korea. However, antibody responses to Cryptosporidium have rarely been studied. Serum antibodies from HIV-positive/oocyst-positive Korean patients recognized significantly 31 and 27 kDa antigens, and HIV-negative/oocyst-positive individuals clearly reacted to 15/17 kDa antigens. Compared with oocyst-positive cases, 18.7% and 75.8% of sera from HIV-positive patients reacted to 31 and 27 kDa antigens. Only 11.1% of HIV-negative individuals reacted to 15/17 kDa. Based on these findings, serum antibody responses were different between HIV-positive and HIV-negative individuals infected with Cryptosporidium, and it is suggested that HIV-positive patients are more frequently exposed to C. parvum compared to HIV-negative individuals.
Guk
Sang-Mee
SM
Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea.
Chai
Jong-Yil
JY
Shin
Yung-Oh
YO
Seo
Min
M
D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000276:immunology*; D000328:Adult; D000368:Aged; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood* / Q000276:immunology; D000917:Antibody Formation; D000953:Antigens, Protozoan / Q000737:chemistry / Q000276:immunology*; D015153:Blotting, Western / Q000379:methods; D003457:Cryptosporidiosis / Q000097:blood / Q000276:immunology*; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D015800:Protozoan Proteins / Q000737:chemistry / Q000276:immunology
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D015800:Protozoan Proteins