Effect of cyanoacrylic glue on penile fracture: an experimental study.
OBJECTIVE
We investigated the effect of Glubran(R)2 cyanoacrylic glue on rat cavernous tissue after forming penile fractures experimentally as well as the histopathological effect. We also investigated its clinical use.


METHODS
Experimental penile fracture was formed by incising from the proximal dorsal side of the penis in 32 Wistar Albino rats. The rats were randomly assigned to 4 main groups of 8 each. In the control group the incision was not repaired and it was left to secondary healing. In the glue group cyanoacrylic glue was only applied to the incision region. In the primary repair group the incision was primarily repaired and in the final group cyanoacrylic glue was applied to the incision region following primary repair. Three weeks later penectomy materials were examined histopathologically.


RESULTS
When the control group was compared with the other groups, the differences in cavernous tissue healing with fibrosis and hyperemia-bleeding were statistically significant (p = 0.043 and 0.003, respectively). In the glue group fibrosis was observed in 2 rats. This group was the best according to cavernous healing. Although there was no significant difference between the control group and the other groups according to inflammation (p = 0.057), the glue group was better than the primary repair group (p = 0.026). No significant inflammation or hyperemia-bleeding was observed in the glue group. When the experimental groups were evaluated for histopathological parameters, it was observed that the best results were obtained in the glue group.


CONCLUSIONS
Cyanoacrylic glue can be used in cavernous surgery due to its hemostatic, adhesive and anti-inflammatory properties.
Departments of Second Urology Clinic and Pathology (EO, HU), Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey. turgayakgul@gmail.com
Turgay
T
Akgül
Ali
A
Ayyildiz
Ozden
O
Cebeci
Bariş
B
Nuhoğlu
Elif
E
Ozer
Cankon
C
Germiyanoğlu
Hüseyin
H
Ustün
D000818:Animals; D016009:Chi-Square Distribution; D003487:Cyanoacrylates / Q000494:pharmacology*; D004195:Disease Models, Animal; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D007150:Immunohistochemistry; D008297:Male; D010413:Penis / Q000293:injuries*; D011336:Probability; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000188:drug therapy*
D003487:Cyanoacrylates; D015718:Fibrin Tissue Adhesive; C421461:glubran 2