Acquired factor VIII and von Willebrand factor (aFVIII/VWF) deficiency and hypothyroidism in a case with hypopituitarism.
This article reports a female who presented with bleeding, acquired factor VIII and von Willebrand factor (aFVIII-VWF) deficiency, and central deficiency in the thyroid and adrenal axis (Sheehan's syndrome). After starting hormone replacement therapy, relief of bleeding manifestations was associated with correction of both FVIII and VWF to normal. This report draws attention to a rare association between the acquired form of von Willebrand disease and hypothyroidism of central origin.
Discipline of Endocrinology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Brasil. mco@portoweb.com.br
Miriam C
MC
Oliveira
Caroline K
CK
Kramer
Caroline P
CP
Marroni
Carolina G S
CG
Leães
Luciana
L
Viana
Sérgio
S
Roithman
Alexandre
A
Schmaedecke
Júlia F S
JF
Pereira-Lima
D000328:Adult; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D006467:Hemophilia A / Q000209:etiology*; D006470:Hemorrhage / Q000097:blood / Q000209:etiology*; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000150:complications*; D014842:von Willebrand Diseases / Q000209:etiology*; D014841:von Willebrand Factor / Q000378:metabolism
D014841:von Willebrand Factor; D005169:Factor VIII