[Research progress of neural stem cells signal transduction pathway].
OBJECTIVE
To summarize Notch, basic helix-loop-helix (bHLH) and Wnt gene signal transduction pathways in the process of differentiation and development of neural stem cells.


METHODS
The literature on the gene signal transduction pathway in the process of differentiation and development of neural stem cells was searched and then summarized and analyzed.


RESULTS
The formation of Nervous System resulted from common actions of multi-signal transduction pathways. There may exist a fixed threshold in the complicated selective system among Notch, bHLH and Wnt gene signal transduction pathways.


CONCLUSIONS
At present, the specific gene signal transduction pathway of multiplication and differentiation of neural stem cells is still unclear.
Zhang
Wenxian
W
Department of Orthopedics, Traditional Chinese Medicine Hospital, Lanzhou Gansu, 730050, P.R. China. DOCzhangwx@126.com
Wang
Yujun
Y
Wang
Xiaoyan
X
Lv
Jianghong
J
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D051880:Receptors, Notch / Q000502:physiology; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D051153:Wnt Proteins / Q000502:physiology
D051792:Basic Helix-Loop-Helix Proteins; D051880:Receptors, Notch; D051153:Wnt Proteins