Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum.
The antitumor activity of six extracts (ethanol extract, petroleum ether fraction, CHCl(3) fraction, ethyl acetate fraction, n-butanol fraction and total alkaloids) from the rhizomes of Veratrum dahuricum, and six compounds (veratramine (1), jervine (2), germine (3), veramitaline (4), veratrosine (5) and cyclopamine (6)) from the ethanol extract were investigated in vitro. The 12 samples exhibited cytotoxic activity against human tumor cell lines A549, PANC-1, SW1990 and NCI-H249. Among these samples, CHCl(3) fraction, the total alkaloids, compounds 1 and 6 showed higher inhibitory activity, compound 3 selectively exhibited significant cytotoxicity to SW1990 and NCI-H249.
School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
Jian
J
Tang
Hui-Liang
HL
Li
Yun-Heng
YH
Shen
Hui-Zi
HZ
Jin
Shi-Kai
SK
Yan
Run-Hui
RH
Liu
Wei-Dong
WD
Zhang
D000970:Antineoplastic Agents / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005591:Chemical Fractionation; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry; D014703:Veratrum / Q000737:chemistry; D014704:Veratrum Alkaloids / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*
D000970:Antineoplastic Agents; D010936:Plant Extracts; D014704:Veratrum Alkaloids