Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects.
Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. Inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). Importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation.
Konger
Raymond L
RL
Department of Pathology, Indiana University, Indianapolis, IN 46202, USA. rkonger@iupui.edu
Marathe
Gopal K
GK
Yao
Yongxue
Y
Zhang
Qiwei
Q
Travers
Jeffrey B
JB
D000818:Animals; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D010084:Oxidation-Reduction / Q000528:radiation effects; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism* / Q000627:therapeutic use; D010972:Platelet Activating Factor / Q000378:metabolism; D014466:Ultraviolet Rays
D047492:Peroxisome Proliferator-Activated Receptors; D010713:Phosphatidylcholines; D010972:Platelet Activating Factor