A potential role for protein tyrosine phosphatase inhibition by a RuIII-edta complex (edta = ethylenediaminetetraacetate) in its biological activity.
[RuIII(edta)(OH2/OH)]1-/2- (edta = ethylenediaminetetraacetate) inhibits protein tyrosine phosphatase (PTP) at physiological pH values in a mechanism that involves binding of the Cys residue of the catalytic domain of the enzyme and similar interactions may be important in the anti-cancer properties of the active forms of many Ru pro-drugs.
Chatterjee
Debabrata
D
Chemistry Group, Central Mechanical Engineering Research Institute, MG Avenue, Durgapur, 713209, India. dchat57@hotmail.com
Mitra
Anannya
A
Levina
Aviva
A
Lay
Peter A
PA
D004492:Edetic Acid / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D017975:Ruthenium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013053:Spectrophotometry; D015008:Yersinia enterocolitica / Q000187:drug effects / Q000201:enzymology
D017975:Ruthenium Compounds; D004492:Edetic Acid; D017027:Protein Tyrosine Phosphatases