8-Amino guanine accelerates tetramolecular G-quadruplex formation.
We demonstrate here that 8-amino guanine () strongly accelerates quadruplex formation, which makes this nucleobase the most attractive replacement for guanine in the context of tetramolecular parallel quadruplexes.
Muséum National d'Histoire Naturelle (MNHN) USM 503, INSERM U565, CRNS UMR 5153, 43 rue Cuvier CP26, F-75231, Paris Cedex 05, France.
Julien
J
Gros
Anna
A
Aviñó
Jaime
J
Lopez de la Osa
Carlos
C
González
Laurent
L
Lacroix
Alberto
A
Pérez
Modesto
M
Orozco
Ramon
R
Eritja
Jean-Louis
JL
Mergny
D001483:Base Sequence; D002942:Circular Dichroism; D054856:G-Quadruplexes; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D013696:Temperature
C033495:8-aminoguanine; D006147:Guanine