[Effect of fetal tissues on the processes of thymus involution in experiment].
The objective of the experiment was to investigate the effect of liver fetal tissue transplantation (LFTT) in adult rats on the morphofunctional state of thymus as the central organ of cell-mediated (cellular) immunity. A positive impact of LFTT on the indices of age-dependent thymus involution has been established. That revealed itself in the corresponding morphological transformations of the microenvironment of thymocytes, changes in their number and composition as well as in the subpopulation composition of lymphocytes of the peripheral blood. The studies undertaken testify to the great possibilities (potentialities) of further research into the application of fetal hemopoietic tissues aimed at correcting age-dependent disorders of the cellular immunity link.
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D000375:Aging / Q000276:immunology / Q000473:pathology / Q000502:physiology; D000818:Animals; D005260:Female; D053686:Fetal Stem Cells / Q000637:transplantation*; D007111:Immunity, Cellular; D008099:Liver / Q000166:cytology / Q000196:embryology; D018655:Lymphocyte Count; D009929:Organ Size / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D013950:Thymus Gland / Q000254:growth & development / Q000276:immunology / Q000473:pathology