Convenient preparation of A-ring fused pyridines from steroidal enamides.
A facile strategy for the preparation of A-ring fused pyridosteroids has been accomplished in high yields by the reaction of Vilsmeier reagent (chloromethyleneiminium salt) with steroidal A-ring enamides (2- and 3-ene) under thermal conditions. The structure of 6'-chloro-5alpha-cholest [3,2-b]pyridine was determined by X-ray analysis.
Barthakur
Madan G
MG
Medicinal Chemistry Division, North-East Institute of Science and Technology, Jorhat, Assam 785006, India.
Borthakur
Moyurima
M
Boruah
Romesh C
RC
D000693:Anaerobiosis; D002625:Chemistry, Organic / Q000379:methods*; D018360:Crystallography, X-Ray; D006358:Hot Temperature; D008968:Molecular Conformation; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry*
D011725:Pyridines; D013256:Steroids