The macrokinetics of an enzymatic system containing an enzyme that inactivates in the course of reaction.
The work describes the action of a heterogenous multisubstrate enzymatic system under conditions involving inactivation of the enzyme. A nonsteady-state kinetic model has been suggested for description of the system. It has been found that the time dependence of the product flow from the membrane is a curve with a maximum which falls on a time equal to the reverse inactivation constant. It has been shown that the efficiency of such systems increases as does the time of the operation of the enzyme.
Moscow State University, Moscow 117234, USSR.
G F
GF
Sud'ina
G M
GM
Kobel'kov
S D
SD
Varfolomeev