Cytotoxic activity of Ipomoea cairica.
(+)-(8R,8'S)-thujaplicatin methyl ether (1), arctigenin (2), matairesinol (3), trans-2,3-dibenzylbutyrolactone (4), vanillic acid (5), p-hydroxybenzoic acid (6), methoxybenzoic acid (7), methylparaben (8), stearic acid (9), palmitic acid (10), olenic acid (11), friedelinol (12), and a mixture of beta-sitosterol (13) and stigmasterol (14) were obtained from the methanolic extract of the Ipomoea cairica (L.) Sweet (Convolvulaceae). The structure of compound 1 was established by spectroscopic analyses. Among them, 2 and 4 were demonstrated to have significant cytotoxicity against LNCaP cell line. Compound 4 was also found to be significantly active against A549 cell line.
Faculty of Medicine, Department of Parasitology, College of Medicine, Kaohsiung Medical University, Taiwan, ROC.
Rong-Jyh
RJ
Lin
Chung-Yi
CY
Chen
Wen-Li
WL
Lo
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D001565:Benzoates / Q000302:isolation & purification; D045744:Cell Line, Tumor; D005227:Fatty Acids / Q000302:isolation & purification; D005663:Furans / Q000302:isolation & purification; D006801:Humans; D027741:Ipomoea / Q000737:chemistry*; D017705:Lignans / Q000302:isolation & purification; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000302:isolation & purification; D010840:Phytosterols / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D001565:Benzoates; D005227:Fatty Acids; D005663:Furans; D017705:Lignans; D010840:Phytosterols; D010936:Plant Extracts; C055670:friedelinol; C068935:matairesinol; C009478:thujaplicatin methyl ether; D009828:Oleanolic Acid; D015107:4-Butyrolactone; C071942:arctigenin