Human topological task adapted for rats: Spatial information processes of the parietal cortex.
Human research has shown that lesions of the parietal cortex disrupt spatial information processing, specifically topological information. Similar findings have been found in non-humans. It has been difficult to determine homologies between human and non-human mnemonic mechanisms for spatial information processing because methodologies and neuropathology differ. The first objective of the present study was to adapt a previously established human task for rats. The second objective was to better characterize the role of parietal cortex (PC) and dorsal hippocampus (dHPC) for topological spatial information processing. Rats had to distinguish whether a ball inside a ring or a ball outside a ring was the correct, rewarded object. After rats reached criterion on the task (>95%) they were randomly assigned to a lesion group (control, PC, and dHPC). Animals were then re-tested. Post-surgery data show that controls were 94% correct on average, dHPC rats were 89% correct on average, and PC rats were 56% correct on average. The results from the present study suggest that the parietal cortex, but not the dHPC processes topological spatial information. The present data are the first to support comparable topological spatial information processes of the parietal cortex in humans and rats.
Department of Physiology and Developmental Biology, Neuroscience Center, Brigham Young University, Provo, UT, USA.
Naomi J
NJ
Goodrich-Hunsaker
Brian P
BP
Howard
Michael R
MR
Hunsaker
Raymond P
RP
Kesner
D000818:Animals; D001931:Brain Mapping; D004193:Discrimination Learning / Q000502:physiology; D004195:Disease Models, Animal; D004292:Dominance, Cerebral / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D009949:Orientation / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology*; D010364:Pattern Recognition, Visual / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D013045:Species Specificity