Expression and putative functions of GDF-15, a member of the TGF-beta superfamily, in human glioma and glioblastoma cell lines.
Recent studies have demonstrated growth-inhibiting effects of growth differentiation factor-15 (GDF-15) on different cancer cell lines invitro and on tumor growth in vivo. Here, we present data concerning expression of GDF-15 in glioblastoma. We found low levels of GDF-15 transcripts in primary glioblastoma. Thus, GDF-15 expression might be exploited as a useful indicator for distinguishing primary from other glial derived tumors. In contrast to the documented proapoptotic and anti-tumorigenic activities of GDF-15 in several cancer cell lines, our data suggest that GDF-15 does not decrease proliferation of glioblastoma cell lines, while its effects on invasiveness are not consistent.
Strelau
Jens
J
Department of Neuroanatomy and Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, INF 307, Heidelberg, Germany. jens.strelau@urz.uni-heidelberg.de
Schmeer
Corina
C
Peterziel
Heike
H
Sackmann
Tina
T
Herold-Mende
Christel
C
Steiner
Hans
H
Weller
Michael
M
Unsicker
Klaus
K
D017209:Apoptosis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D016207:Cytokines / Q000032:analysis / Q000502:physiology*; D005909:Glioblastoma / Q000737:chemistry / Q000473:pathology*; D005910:Glioma / Q000737:chemistry / Q000473:pathology*; D055436:Growth Differentiation Factor 15; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D016207:Cytokines; C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15; D016159:Tumor Suppressor Protein p53