Aggressive multimodal therapy of sporadic malignant insulinoma can improve survival: a retrospective 35-year study of 12 patients.
OBJECTIVE
Sporadic malignant insulinoma (SMI) is a rare disease, and the consequent paucity of data in the literature and the development of aggressive treatments for liver metastases have led us to retrospectively analyze a series of 12 cases of SMI.


METHODS
Every patient presenting with SMI, according to the WHO 2004 histopathology criteria, between 1970 and June 2005 in Marseille was included in the study. Patients with multiple endocrine neoplasia type 1 (MEN-1) and tumours of uncertain malignant potential were excluded.


RESULTS
The ratio of male/female was 4/8, and mean age at diagnosis was 52.5 years. A 48-h fasting test in 10 patients was conclusive in nine, after a mean duration of 12 h 45 min. SMI size ranged from 7-120 mm (mean 30.3mm). Six patients had liver metastases and one had isolated lymph-node invasion. Surgery was performed in 12 patients. Five persisting diseases (mean follow-up of 1.8 years) required other treatments (chemoembolization, radiofrequency thermoablation [RFTA], liver transplantation); one patient relapsed 8.5 years after surgery; six were still in complete remission (mean follow-up of 5.8 years), and one patient had died by the time of the 24-month follow-up.


CONCLUSIONS
Aggressive sequential multimodal therapy can prolong the survival of patients with SMI even in the presence of liver metastases.
Service de nutrition-maladies métaboliques-endocrinologie, hôpital de la Timone, 264, rue Saint-Pierre, 13005 Marseille, France. audrey.begu@mail.ap-hm.fr
A
A
Bégu-Le Corroller
R
R
Valéro
V
V
Moutardier
J-F
JF
Henry
Y-P
YP
Le Treut
M
M
Gueydan
C
C
De Micco
M
M
Sierra
B
B
Conte-Devolx
C
C
Oliver
D
D
Raccah
R
R
Favre
L
L
Digue
M
M
Heim
J-F
JF
Seitz
J-R
JR
Delpero
B
B
Vialettes
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007340:Insulinoma / Q000401:mortality / Q000556:secondary / Q000601:surgery / Q000628:therapy*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000556:secondary / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate