SAPHIR: a physiome core model of body fluid homeostasis and blood pressure regulation.
We present the current state of the development of the SAPHIR project (a Systems Approach for PHysiological Integration of Renal, cardiac and respiratory function). The aim is to provide an open-source multi-resolution modelling environment that will permit, at a practical level, a plug-and-play construction of integrated systems models using lumped-parameter components at the organ/tissue level while also allowing focus on cellular- or molecular-level detailed sub-models embedded in the larger core model. Thus, an in silico exploration of gene-to-organ-to-organism scenarios will be possible, while keeping computation time manageable. As a first prototype implementation in this environment, we describe a core model of human physiology targeting the short- and long-term regulation of blood pressure, body fluids and homeostasis of the major solutes. In tandem with the development of the core models, the project involves database implementation and ontology development.
Informatics, Integrative Biology, and Complex Systems, FRE CNRS 3190, Evry 91000, France. srthomas@ibisc.fr
S Randall
SR
Thomas
Pierre
P
Baconnier
Julie
J
Fontecave
Jean-Pierre
JP
Françoise
François
F
Guillaud
Patrick
P
Hannaert
Alfredo
A
Hernández
Virginie
V
Le Rolle
Pierre
P
Mazière
Fariza
F
Tahi
Ronald J
RJ
White
D000136:Acid-Base Equilibrium / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D001826:Body Fluids / Q000502:physiology; D003198:Computer Simulation; D006706:Homeostasis; D006801:Humans; D051188:Knowledge Bases; D008954:Models, Biological; D008955:Models, Cardiovascular; D010827:Physiology; D049490:Systems Biology