Regulation of mitochondrial antiviral signaling pathways.
Mitochondrial antiviral immunity involves the detection of viral RNA by intracellular pattern-recognition receptors (PRRs) belonging to the RIG-I-like helicase family. The convergence of these and other signaling molecules to the outer mitochondrial membrane results in the rapid induction of antiviral cytokines including type-1 interferon. Here, we discuss recent studies describing new molecules implicated in the regulation of this antiviral response.
Moore
Chris B
CB
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. cbmoore2@med.unc.edu
Ting
Jenny P-Y
JP
D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007370:Interferon Type I / Q000276:immunology / Q000378:metabolism; D008928:Mitochondria / Q000276:immunology / Q000378:metabolism*; D020365:RNA Helicases / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism*; D051192:Receptors, Pattern Recognition / Q000378:metabolism*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism; D014780:Viruses / Q000276:immunology*
D048868:Adaptor Proteins, Signal Transducing; D016207:Cytokines; D007370:Interferon Type I; C505371:MAVS protein, human; D012367:RNA, Viral; D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors; D020365:RNA Helicases