High rate of intestinal colonization with extended-spectrum-beta-lactamase-producing organisms in household contacts of infected community patients.
Fecal carriage of extended-spectrum-beta-lactamase (ESBL)-producing organisms was detected in 70% of index cases of patients (n = 40) with community-acquired infections due to ESBL producers and reached 16.7% in household contacts (n = 54). A total of 66% of ESBL-producing organisms from index cases were indistinguishable from isolates from household contacts by pulsed-field gel electrophoresis. Patients with community infections and members of their households represent a reservoir for ESBL producers, increasing dispersal of resistance in healthy people.
Valverde
Aránzazu
A
Servicio de Microbiología, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Grill
Fabio
F
Coque
Teresa M
TM
Pintado
Vicente
V
Baquero
Fernando
F
Cantón
Rafael
R
Cobo
Javier
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001419:Bacteria / Q000145:classification* / Q000201:enzymology* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000382:microbiology / Q000635:transmission*; D015373:Bacterial Typing Techniques; D002353:Carrier State / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000382:microbiology / Q000635:transmission*; D016172:DNA Fingerprinting; D016521:Electrophoresis, Gel, Pulsed-Field; D005191:Family Characteristics; D005192:Family Health; D005243:Feces / Q000382:microbiology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D001618:beta-Lactamases / Q000032:analysis*
D001618:beta-Lactamases