Varenicline-induced mixed mood and psychotic episode in a patient with a past history of depression.
Varenicline is a promising agent with demonstrated efficacy in the promotion of smoking cessation. However, from the time of initial trials, it has been associated with significant psychiatric adverse effects. We describe a case where mixed mood and psychotic disturbance developed in an individual with a history of depression and a family history of bipolar disorder. Based on this case, we hypothesize a possible mechanism of action for these adverse effects and preventive measures that could be undertaken in its effective use.
Pumariega
Andres J
AJ
Department of Psychiatry, The Reading Hospital and Medical Center, West Reading, PA 19612, USA.
Nelson
Robert
R
Rotenberg
Larry
L
D014150:Antipsychotic Agents / Q000627:therapeutic use; D000068180:Aripiprazole; D001552:Benzazepines / Q000009:adverse effects* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology / Q000628:therapy; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use; D011605:Psychoses, Substance-Induced / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000523:psychology; D011613:Psychotherapy; D015363:Quinolones / Q000627:therapeutic use; D011810:Quinoxalines / Q000009:adverse effects* / Q000627:therapeutic use; D016540:Smoking Cessation; D013315:Stress, Psychological / Q000150:complications; D000068580:Varenicline
D014150:Antipsychotic Agents; D001552:Benzazepines; D010879:Piperazines; D015363:Quinolones; D011810:Quinoxalines; D000068180:Aripiprazole; D000068580:Varenicline