Ames test evaluation of two commercially available zero-valent nickel compounds.
Zero-valent nickel compounds are organometallic chemicals that are used in synthetic applications and may also occur as intermediates in nickel-catalyzed hydrogenation reactions used in food processing. Few studies have been performed on their possible genotoxic actions. We have tested two commercially available examples of this class of compounds. Solubility and stability were examined. Mutagenicity testing did not confirm a previous report that bis(1,5-cyclooctadiene)nickel is positive in the Ames assay. No stimulation of lipid peroxidation was observed in studies of bovine erythrocytes exposed in vitro. Our results do not indicate that zero-valent nickel compounds have genotoxic effects.
Josephy
P David
PD
Department of Molecular and Cellular Biology, College of Biological Science, University of Guelph, Guelph, Ontario, N1G 2W1 Canada. djosephy@uoguelph.ca
Weadge
Jody J
JJ
Meissner
Joseph
J
Ng
Filomena
F
D000818:Animals; D002417:Cattle; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D009152:Mutagenicity Tests; D009153:Mutagens / Q000737:chemistry / Q000633:toxicity*; D009532:Nickel / Q000737:chemistry / Q000633:toxicity*; D009942:Organometallic Compounds / Q000737:chemistry / Q000633:toxicity*; D012995:Solubility; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D009153:Mutagens; D009942:Organometallic Compounds; D017392:Thiobarbituric Acid Reactive Substances; D009532:Nickel