Visual acuity is related to parafoveal retinal thickness in patients with retinitis pigmentosa and macular cysts.
OBJECTIVE
To quantify the prevalence and effect on visual acuity of macular cysts in a large cohort of patients with retinitis pigmentosa.


METHODS
In 316 patients with typical forms of retinitis pigmentosa, visual acuity was measured with Early Treatment Diabetic Retinopathy Study (ETDRS) charts, macular cysts were detected with optical coherence tomography (OCT), and retinal thicknesses was quantified by OCT. The FREQ, LOGISTIC, and GENMOD procedures of SAS (SAS Institute, Cary, NC) were used to evaluate possible risk factors for cyst prevalence, and the MIXED procedure was used to quantify the relationships of visual acuity to retinal thickness measured at different locations within the macula.


RESULTS
Macular cysts were found in 28% of the patients, 40% of whom had cysts in only one eye. Macular cysts were seen most often in patients with dominant disease and not at all in patients with X-linked disease (P = 0.006). In eyes with macular cysts, multiple regression analysis revealed that visual acuity was inversely and independently related to retinal thickness at the foveal center (P = 0.038) and within a parafoveal ring spanning an eccentricity of 5 degrees to 10 degrees from the foveal center (P = 0.004).


CONCLUSIONS
Macular cysts are a common occurrence in retinitis pigmentosa, especially among patients with dominantly inherited disease. Visual acuity is influenced by edema in the parafovea, as well as in the fovea.
The Berman-Gund Laboratory, Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA. masandberg@aol.com
Michael A
MA
Sandberg
Robert J
RJ
Brockhurst
Alexander R
AR
Gaudio
Eliot L
EL
Berson
D000293:Adolescent; D000328:Adult; D000368:Aged; D001837:Body Weights and Measures; D005260:Female; D005584:Fovea Centralis; D006801:Humans; D008269:Macular Edema / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012160:Retina / Q000473:pathology*; D012174:Retinitis Pigmentosa / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D012307:Risk Factors; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*