[Change in bone mineral density in female patients with hyperthyroidism].
OBJECTIVE
To investigate the effect of the course and menopause on the change of bone mineral density (BMD) in female patients with hyperthyroidism.


METHODS
BMDs of hip and lumbar vertebrae were measured by dual-energy X-rays absorptiometry(DEXA) in the female patients (n=192, aged 14 approximately 72). Patients were divided into 2 groups (premenopausal and postmenopausal)and 2 subgroups(short-course and long-course). The BMDs were compared between those of age-matched, weight-matched, height-matched and body mass index matched control subgroups.


RESULTS
In the premenopausal hyperthyroidic patients, only the BMDs of the second and total lumbar vertebrae with long-course were significantly lower than those of short-course group(P< 0.05). In the post-menopausal group with the long-course,each BMD measured had a lower level compared with that with short-course, of which the hip and the second lumber vertebrae were evident (P< 0.01).


CONCLUSIONS
The course and menopause have an effect on the BMDs in female patients with hyperthyroidism.
Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, China.
Hong
H
Zhang
Ai-ling
AL
Ye
Er-yuan
EY
Liao
D000293:Adolescent; D000328:Adult; D000368:Aged; D015519:Bone Density; D005260:Female; D006621:Hip Joint; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism*; D008159:Lumbar Vertebrae; D008593:Menopause / Q000378:metabolism*; D008875:Middle Aged