Age-related changes in endothelin-1 receptor subtypes in rat heart.
Density, affinity, and subtype distribution of endothelin-1 (ET-1) binding sites were determined in rat cardiac tissue as a function of age in order to evaluate the association of alterations in the endothelin receptor system and aging in the heart. A significant decrease in the receptor subtype ET-A, which represents 70% to 80% of the total receptor population in cardiac tissue of 3- and 12-month-old rats, was observed in 24-month-old rats with respect to the younger groups. These findings indicate an alteration in ET-1 cardiac receptors associated with aging, mainly due to a variation in the receptor subtype distribution.
CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy.
Silvia
S
Del Ry
Maristella
M
Maltinti
Daniela
D
Giannessi
Gabriella
G
Cavallini
Ettore
E
Bergamini
D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D003164:Competitive Bidding; D019332:Endothelin-1 / Q000493:pharmacokinetics; D005786:Gene Expression Regulation; D006321:Heart / Q000000981:diagnostic imaging; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011869:Radioligand Assay; D011877:Radionuclide Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley; D044022:Receptor, Endothelin A / Q000032:analysis / Q000235:genetics*; D044023:Receptor, Endothelin B / Q000032:analysis / Q000235:genetics
D019332:Endothelin-1; D007457:Iodine Radioisotopes; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B