A Role for PPARgamma in the Regulation of Cytokines in Immune Cells and Cancer.
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. PPARgamma and its ligands appear to serve diverse biological functions. In addition to the well-studied effects of PPARgamma on metabolism and cellular differentiation, abundant evidence suggests that PPARgamma is an important regulator of the immune system and cancers. Since cytokines are not only key modulators of inflammation with pro- and anti-inflammatory functions but they also can either stimulate or inhibit tumor growth and progression, this review summarizes the role for PPARgamma in the regulation of cytokine production and cytokine-mediated signal transduction pathways in immune cells and cancer.
Yang
Xiao Yi
XY
Basic Research Program, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, MD 21702, USA.
Wang
Li Hua
LH
Farrar
William L
WL