Inflammation in renal atherosclerotic disease.
The study of renal atherosclerotic disease has conventionally focused on the diagnosis and management of renal artery stenosis. With the increased understanding of atherosclerosis as a systemic inflammatory process, there has been increased interest in vascular biology at the microvasculature level. While different organ beds share some features, the inflammation and injury in the microvasculature of the kidney has unique elements as well. Understanding of the pathogenesis yields a better understanding of the clinical manifestations of renal atherosclerotic disease, which can be very subtle. Furthermore, identifying the molecular mechanisms responsible for the progression of kidney damage can also direct clinicians and scientists toward targeted therapies. Existing therapies used to treat atherosclerotic disease in other vascular beds may also play a role in the treatment of renal atherosclerotic disease.
Udani
Suneel M
SM
Division of General Internal Medicine, Department of Medicine, John H Stroger Jr Hospital of Cook County, 1900 W Polk St, Chicago, IL 60612, USA. suneel.udani@gmail.com
Dieter
Robert S
RS
D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D007674:Kidney Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D012078:Renal Artery Obstruction / Q000188:drug therapy / Q000503:physiopathology