Relationship between serum progesterone and tumor necrosis factor production in postmenopausal women undergoing estrogen/medroxyprogesterone therapy.
Changes in tumor necrosis factor (TNF) production by lipopolysaccharide-stimulated peripheral blood mononuclear cells significantly correlated with serum P levels in postmenopausal women subjected to estrogen/medroxyprogesterone therapy. This may suggest that low physiologic or hormone therapy-related changes of serum P in healthy postmenopausal women may affect an ability of peripheral blood mononuclear leukocytes to produce TNF, thus having an impact on a variety of TNF-dependent physiologic and pathologic phenomena.
Department of Histology and Embryology, Center of Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
Urszula
U
Stopińska-Głuszak
Jarosław
J
Jóźwiak
Dariusz
D
Radomski
Olgierd
O
Głuszak
Piotr I
PI
Roszkowski
Jacek
J
Malejczyk
D000328:Adult; D004359:Drug Therapy, Combination; D015914:Estrogen Replacement Therapy / Q000379:methods*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008525:Medroxyprogesterone / Q000494:pharmacology*; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood* / Q000187:drug effects*; D011374:Progesterone / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D004967:Estrogens; D014409:Tumor Necrosis Factor-alpha; D011374:Progesterone; D008525:Medroxyprogesterone