Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats.
Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.
Department of Neurosurgery, Ondokuz Mayis University, Samsun, Turkey.
Ahmet H
AH
Kaya
Rinske
R
Vlamings
Sonny
S
Tan
Lee Wei
LW
Lim
Peter J
PJ
Magill
Harry W M
HW
Steinbusch
Veerle
V
Visser-Vandewalle
Trevor
T
Sharp
Yasin
Y
Temel
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D003714:Denervation; D004298:Dopamine / Q000172:deficiency; D003576:Electron Transport Complex IV / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology; D008297:Male; D008636:Mesencephalon / Q000166:cytology / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D016627:Oxidopamine; D020734:Parkinsonian Disorders / Q000503:physiopathology*; D011903:Raphe Nuclei / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism; D013565:Sympatholytics; D009435:Synaptic Transmission / Q000502:physiology; D015854:Up-Regulation / Q000502:physiology
D013565:Sympatholytics; D012701:Serotonin; D016627:Oxidopamine; D003576:Electron Transport Complex IV; D004298:Dopamine