SAPHIR: a physiome core model of body fluid homeostasis and blood pressure regulation.
We present the current state of the development of the SAPHIR project (a Systems Approach for PHysiological Integration of Renal, cardiac and respiratory function). The aim is to provide an open-source multi-resolution modelling environment that will permit, at a practical level, a plug-and-play construction of integrated systems models using lumped-parameter components at the organ/tissue level while also allowing focus on cellular- or molecular-level detailed sub-models embedded in the larger core model. Thus, an in silico exploration of gene-to-organ-to-organism scenarios will be possible, while keeping computation time manageable. As a first prototype implementation in this environment, we describe a core model of human physiology targeting the short- and long-term regulation of blood pressure, body fluids and homeostasis of the major solutes. In tandem with the development of the core models, the project involves database implementation and ontology development.
Thomas
S Randall
SR
Informatics, Integrative Biology, and Complex Systems, FRE CNRS 3190, Evry 91000, France. srthomas@ibisc.fr
Baconnier
Pierre
P
Fontecave
Julie
J
Françoise
Jean-Pierre
JP
Guillaud
François
F
Hannaert
Patrick
P
Hernández
Alfredo
A
Le Rolle
Virginie
V
Mazière
Pierre
P
Tahi
Fariza
F
White
Ronald J
RJ
D000136:Acid-Base Equilibrium / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D001826:Body Fluids / Q000502:physiology; D003198:Computer Simulation; D006706:Homeostasis; D006801:Humans; D051188:Knowledge Bases; D008954:Models, Biological; D008955:Models, Cardiovascular; D010827:Physiology; D049490:Systems Biology