Cyathuscavins A, B, and C, new free radical scavengers with DNA protection activity from the Basidiomycete Cyathus stercoreus.
Three new polyketides, cyathuscavins A (1), B (2), and C (3) were isolated from the mycelium culture of Cyathus stercoreus. The structures of the compounds were elucidated on the basis of NMR and mass spectroscopic data. Antioxidant activities of the compounds were evaluated by the scavenging ability against ABTS(+), DPPH, and superoxide anion radicals. Cyathuscavins A-C showed significant antioxidant activity comparable to those of reference antioxidants, BHA and Trolox. Cyathuscavins A-C protected supercoiled plasmid DNA from Fe(2+)/H(2)O(2)-induced breakage.
Kang
Hahk-Soo
HS
Korea Research Institute of Bioscience and Biotechnology, Functional Metabolite Research Center, 52 Eoeun-dong, Yuseong, Daejeon 305-806, Republic of Korea.
Kim
Kyoung-Rok
KR
Jun
Eun-Mi
EM
Park
Soon-Hye
SH
Lee
Tae-Soo
TS
Suh
Joo-Won
JW
Kim
Jong-Pyung
JP
D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism; D001487:Basidiomycota / Q000378:metabolism*; D001713:Biphenyl Compounds / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002839:Chromans / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D015195:Drug Design; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006834:Hydrazines / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry; D018942:Macrolides / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008956:Models, Chemical; D010851:Picrates; D013481:Superoxides / Q000737:chemistry
D000975:Antioxidants; D001713:Biphenyl Compounds; D002839:Chromans; D016166:Free Radical Scavengers; D006834:Hydrazines; D018942:Macrolides; D010851:Picrates; C532915:cyathuscavin A; C532916:cyathuscavin B; C532917:cyathuscavin C; D013481:Superoxides; D004247:DNA; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid