Reversal of severe parenteral nutrition-associated liver disease in an infant with short bowel syndrome using parenteral fish oil (Omega-3 fatty acids).
Total parenteral nutrition is an important adjunct in the care of neonates with surgical disorders. Cholestasis is at present the most worrisome complication of this technique; it is difficult to treat and may progress to eventual cirrhosis and liver failure. This article reviews the pertinent clinical and nutritional data in a surgical patient with short bowel syndrome who developed parenteral nutrition-associated liver disease successfully treated with fish-oil based lipids.
Ekema
George
G
Department of Pediatric Surgery, University of Brescia and Civil Hospitals, Brescia, Italy. ekema@med.unibs.it
Falchetti
Diego
D
Boroni
Giovanni
G
Tanca
Anna Rita
AR
Altana
Cristian
C
Righetti
Laura
L
Ridella
Michela
M
Gambarotti
Marco
M
Berchich
Luisa
L
D002760:Cholangiopancreatography, Endoscopic Retrograde; D002763:Cholecystectomy / Q000379:methods; D002779:Cholestasis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005395:Fish Oils / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D045822:Intestinal Volvulus / Q000175:diagnosis / Q000601:surgery; D008107:Liver Diseases / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D008111:Liver Function Tests; D008297:Male; D010289:Parenteral Nutrition, Total / Q000009:adverse effects* / Q000379:methods; D011183:Postoperative Complications / Q000175:diagnosis; D012086:Reoperation; D012720:Severity of Illness Index; D012778:Short Bowel Syndrome / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D047929:Term Birth; D016896:Treatment Outcome
D005395:Fish Oils