Gender difference in the miotic potency of soman vapor in rats.
The present study was undertaken to investigate the miotic potency of soman vapor in the rat, as well as gender differences in the miotic response to soman vapor that have been reported previously for other nerve agents. The results of the present study demonstrate that the miotic potency of soman vapor is significantly less than that of other nerve agents, and that female rats are 2.5-3.0 times more sensitive to soman vapor than male rats. The results also demonstrate that ocular acetylcholinesterase and butyrylcholinesterase activities differ between males and females, although this difference is not likely large enough to account for the observed gender difference.
Dabisch
Paul A
PA
Operational Toxicology Team, U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland 21010-5424, USA. paul.a.dabisch@us.army.mil
Horsmon
Michael S
MS
Taylor
James T
JT
Muse
William T
WT
Miller
Dennis B
DB
Sommerville
Douglas R
DR
Mioduszewski
Robert J
RJ
Thomson
Sandra
S
D000110:Acetylcholinesterase / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D002091:Butyrylcholinesterase / Q000097:blood; D002619:Chemical Warfare Agents / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D005123:Eye / Q000033:anatomy & histology / Q000187:drug effects* / Q000201:enzymology; D005260:Female; D007259:Infrared Rays; D008297:Male; D015877:Miosis / Q000139:chemically induced*; D023421:Models, Animal; D009943:Organophosphorus Compounds / Q000494:pharmacology; D009946:Organothiophosphorus Compounds / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics; D012999:Soman / Q000494:pharmacology*
D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D009946:Organothiophosphorus Compounds; D012999:Soman; C009680:VX-agent; C053914:cyclohexyl methylphosphonofluoridate