[Echinocandins in invasive candidiasis].
Invasive fungal infections on the intensive care unit are predominantly caused by Candida spp., most frequently manifesting as candidemia. In spite of increasing treatment options during the last 2 decades, mortality of invasive candidiasis remains high with 20-50%. With the echinocandins, a new class of antifungal drugs with activity against clinically relevant Aspergillus and Candida spp. has become available since the beginning of the new millennium. The echinocandins have shown convincing efficacy in numerous multicenter, mostly double-blinded phase III clinical trials. These trials compared current standard treatment regimens with the echinocandins anidulafungin, caspofungin, and micafungin. All trials observed noninferiority of the new drugs against the standard treatment; in the case of anidulafungin, superiority against fluconazole was demonstrated. Especially in trials utilizing amphotericin B as comparator, significantly less treatment-related adverse events were observed when using an echinocandin. Echinocandins have a low drug-drug interaction profile and are only marginally affected by liver function. Especially in ICU (intensive care unit) patients frequently showing single- or multiorgan failure and receiving a multitude of drugs with complex interactions, echinocandins have become the treatment of first choice for invasive candidiasis.
Glöckner
Andreas
A
Neurologisches Rehabilitationszentrum, Greifswald. a.gloeckner@nrz-greifswald.de
Cornely
Oliver A
OA
D000935:Antifungal Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002177:Candidiasis / Q000097:blood / Q000188:drug therapy*; D017326:Clinical Trials, Phase III as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D054714:Echinocandins / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016469:Fungemia / Q000097:blood / Q000188:drug therapy*; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D015337:Multicenter Studies as Topic
D000935:Antifungal Agents; D054714:Echinocandins