Excellent outcome after prolonged status epilepticus due to non-paraneoplastic limbic encephalitis.
Limbic encephalitis (LE) is frequently associated with malignancy. Non-paraneoplastic LE is less common and in this form, voltage-gated potassium channel (VGKC) antibodies are usually found. However in 2007 the spectrum was further extended by a report on four patients with presumed non-paraneoplastic LE in whom neither VGKC-antibodies nor other antibodies could be found (Samarasekera et al. 2007). Despite immunmodulatory treatment all these patients had severe neurological residual symptoms. Here we describe a further patient in whom extensive diagnostic procedures suggested non-paraneoplastic antibody-negative limbic encephalitis. Although this woman had prolonged status epilepticus during seven weeks, her outcome was excellent.
Department of Neurology and Neurophysiology, Sahlgrenska University Hospital, Göteborg, Sweden. daniel_kondziella@yahoo.com
Daniel
D
Kondziella
Oluf
O
Andersen
Fredrik
F
Asztely
Björn
B
Holmberg
Anders
A
Hedström
Eva
E
Szentgyörgyi
D000328:Adult; D000647:Amnesia / Q000209:etiology; D000927:Anticonvulsants / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood; D020274:Autoimmune Diseases of the Nervous System / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004833:Epilepsy, Temporal Lobe / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006624:Hippocampus / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D020363:Limbic Encephalitis / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000627:therapeutic use; D010554:Personality Disorders / Q000209:etiology; D010956:Plasmapheresis; D013226:Status Epilepticus / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D016896:Treatment Outcome
D000927:Anticonvulsants; D001323:Autoantibodies; D008775:Methylprednisolone