Ultrasound assisted synthesis of some new 1,3,4-thiadiazole and bi(1,3,4-thiadiazole) derivatives incorporating pyrazolone moiety.
Novel substituted 1,3,4-thiadiazole and bi(1,3,4-thiadiazole) were synthesized from reaction of 1-methyl-5-oxo-3-phenyl-2-pyrazolin-4-thiocarbox-anilide with a series of different hydrazonyl halides or N,N'-diphenyl-oxalodihydrazonoyl dichloride. The reactions were carried out under both conventional and ultrasonic irradiation conditions. In general, improvement in rates and yields were observed when reactions were carried out under sonication compared with classical condition. Structures of the products were established on analytical and spectral data.
Department of Green Chemistry, National Research Centre, Dokki, Cairo 12622, Egypt. naglaa_r@yahoo.com
Naglaa M
NM
Abd El-Rahman
Tamer S
TS
Saleh
Mohamed F
MF
Mady