Motion-frozen myocardial perfusion SPECT improves detection of coronary artery disease in obese patients.
In this study, we compared the diagnostic performance of the standard SPECT with motion-frozen (MF) myocardial perfusion SPECT (MPS) in obese patients.


METHODS
A total of 90 consecutive obese patients (body mass index, 30.1-46.8, average, 34.3 +/- 3.6; age, 63 +/- 12 y; 30% women) underwent standard supine rest (201)Tl/stress (99m)Tc dual-isotope gated MPS and cardiac catheterization within 3 mo. MF images were obtained by nonlinear warping of cardiac phases to the end-diastolic position. Total perfusion deficit (TPD) was obtained for summed (S-TPD) and motion-frozen (MF-TPD) datasets with sex-specific standard and MF normal limits.


RESULTS
The area under the receiver-operating-characteristic (ROC) curve for detection of coronary artery disease (CAD) by MF-TPD was significantly larger than that for S-TPD (0.93 +/- 0.25 vs. 0.88 +/- 0.32, P < 0.05). MF-TPD had higher specificity (77% vs. 55%, P < 0.05) and accuracy (89% vs. 80%, P < 0.05) than did S-TPD.


CONCLUSIONS
MF processing of MPS improves CAD detection in obese patients.
Suzuki
Yasuyuki
Y
Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Slomka
Piotr J
PJ
Wolak
Arik
A
Ohba
Muneo
M
Suzuki
Shoji
S
De Yang
Ling
L
Germano
Guido
G
Berman
Daniel S
DS
D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003326:Coronary Circulation; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009038:Motion; D009765:Obesity / Q000150:complications*; D015899:Tomography, Emission-Computed, Single-Photon