Successful use of anakinra to treat refractory Schnitzler's syndrome.
Schnitzler's syndrome is a rather rare disease which may appear in a rheumatologist's office because patients often report rheumatic symptoms with joint, bone and muscle pain. However, it is characterized by chronic urticaria, recurrent fever, liver and spleen enlargement, osteosclerosis, and lymphadenopathy, in conjunction with a serum IgM M component. A patient who had been treated with relatively high doses of corticosteroids for 10 years with insufficient response was treated with the IL-1 receptor antagonist anakinra, this led to a complete resolution of symptoms.
Rheumazentrum Ruhrgebiet, St. Josef Krankenhaus, Herne, Germany.
F
F
Dybowski
N
N
Sepp
H J
HJ
Bergerhausen
J
J
Braun
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use*; D011859:Radiography; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors; D019873:Schnitzler Syndrome / Q000000981:diagnostic imaging / Q000188:drug therapy*
D000305:Adrenal Cortex Hormones; D018501:Antirheumatic Agents; D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1