Protective effects of melatonin on oxidative-antioxidative balance and cataract formation in rats.
We investigated the effects of melatonin on cataract formation in rats exposed to selenite. We concluded that the imbalance between oxidants and antioxidants plays an important role in cataract formation and melatonin decreases cataract incidence in rats by increasing antioxidant activity.
Department of Ophthalmology, Faculty of Medicine, Yüzüncü Yil University, Van, Turkey. kilicadil@gmail.com
Adil
A
Kiliç
Sahbettin
S
Selek
Ozcan
O
Erel
Nurten
N
Aksoy
D000818:Animals; D000831:Animals, Newborn; D000975:Antioxidants / Q000627:therapeutic use*; D043303:Aryldialkylphosphatase / Q000378:metabolism; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002386:Cataract / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite
D000975:Antioxidants; D002374:Catalase; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; D018038:Sodium Selenite; D008550:Melatonin