Lung adenocarcinoma, dermatomyositis, and Lambert-Eaton myasthenic syndrome: a rare combination.
The incidence of lung neoplasms is increasing in Brazil and in the world, probably as a result of the increase in smoking. Due to the greater number of cases, atypical presentations appear. We report the case of a 66-year-old hypertensive male smoker who presented progressive proximal muscular weakness and, in two months, evolved to dysphagia, dysphonia, and V-shaped skin lesions on the chest. A chest X-ray showed a spiculated pulmonary nodule in the right upper lobe. The biochemical analysis revealed elevated creatine kinase levels. After complementary tests and biopsies, the patient underwent right upper lobectomy. Histopathology showed a moderately differentiated adenocarcinoma. The overall analysis of the case and a review of the literature allow us to suggest that the clinical profile of the patient was a result of an overlap of two paraneoplastic syndromes (dermatomyositis and Lambert-Eaton myasthenic syndrome) secondary to lung adenocarcinoma.
Milanez
Fernanda Manente
FM
Francisco Morato de Oliveira Hospital for State Civil Servants - São Paulo, Brazil. femanente@terra.com.br
Pereira
Carlos Alberto de Castro
CA
Trindade
Pedro Henrique Duccini Mendes
PH
Milinavicius
Ricardo
R
Coletta
Ester Nei Aparecida Martins
EN
D000230:Adenocarcinoma / Q000150:complications*; D000368:Aged; D001706:Biopsy; D018288:Carcinoma, Small Cell / Q000150:complications*; D003402:Creatine Kinase / Q000097:blood; D003882:Dermatomyositis / Q000150:complications*; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications*; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D014057:Tomography, X-Ray Computed
D003402:Creatine Kinase