Normal neurological outcome in two infants treated with exchange transfusions born to mothers with Crigler-Najjar Type 1 disorder.
Patients with Crigler-Najjar Type 1 (CN-1) disorder have an unconjugated hyperbilirubinaemia due to the complete absence in activity of uridinediphosphate glucuronosyltransferase, a bilirubin-conjugating enzyme. In pregnant women with CN-1, the foetus is at high risk of being adversely affected by the bilirubin, as unconjugated bilirubin can cross the placenta and is potentially neurotoxic. We report the long-term outcomes of two infants born to women with CN-1. These infants had exchange transfusions soon after birth and have normal neurodevelopmental outcomes at 18 months and four years of age, respectively. We propose that this intervention might have improved the neurological outcome of these infants.
Department of Child Health, Kings College Hospital, London, SE5 9RS, UK. simon.hannam@kcl.ac.uk
Simon
S
Hannam
Paul
P
Moriaty
Helen
H
O'Reilly
John S
JS
Craig
Michael A
MA
Heneghan
Alastair
A
Baker
Anil
A
Dhawan
D000328:Adult; D001663:Bilirubin / Q000097:blood; D003414:Crigler-Najjar Syndrome / Q000097:blood* / Q000150:complications / Q000628:therapy*; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010789:Phototherapy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000628:therapy*; D011256:Pregnancy Outcome; D011295:Prenatal Care / Q000379:methods; D016216:Ultrasonography, Prenatal; D055815:Young Adult
D001663:Bilirubin