Rapid dose-dependent effect of clozapine on a schizophrenic patient's lipid profile.
Clozapine is known to be associated with higher risk of metabolic syndrome, including dyslipidaemia, but the mechanisms of such a relationship are still under debate. The case we reported shows a seemingly dose-dependent effect of clozapine on a patient's lipid profiles with no influence on his blood sugar in a relatively short period of time. A direct effect of clozapine on lipid metabolism, independent of insulin or obesity-related metabolic changes, is suggested. The rapid effect of clozapine on lipid profile allows fine-tuning in dose adjustment while treating refractory schizophrenia complicated with drug-related dyslipidaemia but worrying about psychotic rebound during clozapine discontinuation.
Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan.
H L
HL
Chiang
C C
CC
Liu
T J
TJ
Hwang
D014150:Antipsychotic Agents / Q000009:adverse effects*; D003024:Clozapine / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D050171:Dyslipidemias / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy* / Q000378:metabolism*; D013997:Time Factors
D014150:Antipsychotic Agents; D003024:Clozapine