Serum cyclosporine level and orange juice in pediatric renal-transplanted patients.
Organ transplant survival has been improved with CsA, but the PK of CsA may be affected by many drugs and foods. This study was performed to investigate the impact of orange juice on PK of CsA in children who had received a renal transplant. This cross-over placebo-controlled study was performed on 10 pediatric kidney-transplanted patients. All children received orange juice (Thomson novel) or water. After morning dose of CsA, patients were given 250 mL orange juice or water and investigation of the PK was performed in 12 h. Co-administration of orange juice with CsA compared with water did not significantly increase the area under the curve from 0-12 h (AUC(0-12)) of CsA (orange juice 2833 +/- 553, water 3053 +/- 1532, p > 0.05). Also, there were not significant effects on peak concentration (C(max)) or time to C(max) (t(max)). Orange juice can be used with CsA and there was no interaction between the juice and CsA in pediatric renal transplants.
Sorkhi
Hadi
H
Department of Kidney Transplantation, Babol University of Medical Sciences, Babol, Iran. hadisorkhi@bprc.ir
Moghadamnia
Ali Akbar
AA
Oaliaee
Farshid
F
PourAmir
Mehdi
M
Firoozjahi
Ali Reza
AR
Pasha
Abazar Akbarzadeh
AA
Goodarzi
Mohammad Rad
MR
D000293:Adolescent; D001628:Beverages; D002648:Child; D032084:Citrus sinensis; D018592:Cross-Over Studies; D016572:Cyclosporine / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000493:pharmacokinetics*; D016030:Kidney Transplantation; D008297:Male
D007166:Immunosuppressive Agents; D016572:Cyclosporine