Surface nanocrystallization of hydroxyapatite coating.
Nanocharactered biomaterials, such as nanopowders, nanocrystalline compacts and nanostructured films, as well as materials with nanoscale roughness, have attracted much attention recently, due to their clear effects on cell response. Surface nanocrystallization of plasma-sprayed hydroxyapatite (HA) coating can be realized by conventional post-heat treatment. This study reveals that 20-30nm nanocrystals formed on HA coatings post-heat treated at 650 degrees C, and the increase in holding time increased the number of surface nanocrystals and intensified their aggregation. Hard aggregation occurred when HA coatings were repetitively post-heat treated. This indicates that the surface nanocrystallization is controllable. Cell experiments were carried out with rat calvarial osteoblasts. The post-heat treated HA coatings exhibit an obviously better osteoblast response than the as-sprayed coatings. Well-flattened cells attached themselves to the coating surfaces, with a good interaction between their filopodia and the nanocrystallized region. It is proposed that the surface nanocrystallization should be taken into account when the post-heat treatment process is introduced for the fabrication of HA coatings.
Lu
Yu-Peng
YP
School of Materials Science and Engineering, Shandong University, Ji'nan 250061, China. Biosdu@sdu.edu.cn
Chen
Yan-Mei
YM
Li
Shi-Tong
ST
Wang
Jian-Hua
JH
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002448:Cell Adhesion; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D006358:Hot Temperature; D053761:Nanocomposites / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry; D010006:Osteoblasts / Q000378:metabolism; D011208:Powders; D051381:Rats; D017208:Rats, Wistar; D013499:Surface Properties; D013696:Temperature
D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D011208:Powders; D017886:Durapatite