Nanobiotechnological modification of hemoglobin and enzymes from this laboratory.
Polyhemoglobin is formed by the nanobiotechnological assembling of hemoglobin molecules into soluble nanodimension complex. A further step involves the nanobiotechnological assembly of hemoglobin, catalase and superoxide dismutase into a soluble nanodimension complex. This acts both as oxygen carrier and antioxidant to prevent the oxidative effects of hemoglobin. A further step is the preparation of nanodimension artificial red blood cells that contain hemoglobin and all the enzymes present in red blood cells. Other approaches include a polyhemoglobin-fibrinogen that acts as an oxygen carrier with platelet-like activity, and a polyhemoglobin-tyrosinase to retard the growth of a fatal skin cancer, melanoma.
Chang
Thomas Ming Swi
TM
Artificial Cells & Organs Research Centre of the Departments of Physiology, Medicine & Biomedical Engineering, Faculty of Medicine, McGill University, 3655, Drummond Street, Montreal, Quebec, Canada H3G 1Y6. artcell.med@mcgill.ca
D000818:Animals; D001802:Blood Substitutes / Q000737:chemistry* / Q000494:pharmacology; D002374:Catalase / Q000737:chemistry*; D003167:Complement Activation / Q000187:drug effects; D003432:Cross-Linking Reagents; D005340:Fibrinogen / Q000737:chemistry / Q000378:metabolism; D006441:Hemoglobin A / Q000737:chemistry* / Q000378:metabolism; D006454:Hemoglobins / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D012157:Mononuclear Phagocyte System / Q000502:physiology; D036103:Nanotechnology / Q000379:methods*; D010108:Oxyhemoglobins / Q000737:chemistry* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000737:chemistry*
D001802:Blood Substitutes; D003432:Cross-Linking Reagents; D006454:Hemoglobins; D010108:Oxyhemoglobins; C037158:polyhemoglobin; D005340:Fibrinogen; D006441:Hemoglobin A; D002374:Catalase; D013482:Superoxide Dismutase