Genomic research and incidental findings.
The Human Genome Project showed that there is significant genetic variation within the population. Current research is accumulating large databases that may reveal genetic variations associated with disease or health risks, even if not intended as part of the study design. These incidental findings create legal, ethical, and financial challenges for researchers. Current federal and international guidelines are not adequate. Plans for dealing with incidental findings need to be established in the study design and reviewed and approved by the Institutional Review Board.
Department of Genetics, Cell Biology & Development at the University of Minnesota, MN, USA.
Brian
B
Van Ness
D030881:Disclosure / Q000941:ethics*; D036281:Genetic Research / Q000941:ethics*; D014644:Genetic Variation / Q000941:ethics*; D023281:Genomics / Q000706:statistics & numerical data / Q000639:trends*; D006801:Humans; D033162:Incidental Findings