Acid test: lipid antigens get into the groove.
How do CD1 molecules load lipid antigens? In this issue of Immunity, Relloso et al. (2008) uncover how lysosomal pH targets amino acids in CD1b, causing it to open and attain a conformation more receptive to lipid antigens.
Kronenberg
Mitchell
M
La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA. mitch@liai.org
Sullivan
Barbara A
BA
D000818:Animals; D017951:Antigen Presentation; D018949:Antigens, CD1 / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000276:immunology*; D011487:Protein Conformation
D018949:Antigens, CD1; D008055:Lipids