Outcomes of melanoma in recipients of solid organ transplant.
BACKGROUND
There is concern that the immunologic tumor malignant melanoma (MM) may have worse outcomes in immunosuppressed hosts than in the general population.


OBJECTIVE
We sought to describe outcomes of MM in immunosuppressed solid organ transplant recipients and compare them with the general population.


METHODS
We conducted a retrospective review of medical charts and pathology slides of cases of MM and solid organ transplantation between 1978 and 2007, with comparison of outcomes.


RESULTS
In all, 48 MMs were identified in 43 transplant recipients. No patient with MM before transplant receipt had melanoma recurrence, subsequent metastasis, or death caused by melanoma. Of patients with MM diagnosed after transplantation, metastases developed in 3 patients, and two patients died of melanoma.


CONCLUSIONS
Retrospective review and low number of cases are limitations.


CONCLUSIONS
Outcomes of MM in immunosuppressed transplant recipients appeared similar to those in prognostically matched nonimmunosuppressed hosts. The small number of cases limited statistical comparisons.
Dapprich
Daniel C
DC
Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Weenig
Roger H
RH
Rohlinger
Audrey L
AL
Weaver
Amy L
AL
Quan
Katherine K Lim
KK
Keeling
James H
JH
Walsh
John S
JS
Otley
Clark C
CC
Christenson
Leslie J
LJ
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D053208:Kaplan-Meier Estimate; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000556:secondary; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016377:Organ Transplantation; D011379:Prognosis; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000556:secondary; D013997:Time Factors; D014481:United States