Intravascular ultrasound assessment of expansion of the sirolimus-eluting (cypher select) and paclitaxel-eluting (Taxus Express-2) stent in patients with diabetes mellitus.
Patients with diabetes have a higher risk for in-stent restenosis after coronary stent implantation. Drug-eluting stents (DES) are highly effective in reducing in-stent restenosis. Once neointimal hyperplasia is suppressed with DES, the impact of stent underexpansion becomes magnified. The aim of this study was to evaluate DES expansion in patients with diabetes. Ninety-five patients with diabetes were randomized to Cypher Select (n = 48) or Taxus Express-2 (n = 47) stent implantation. Intravascular ultrasound was performed after stent implantation. Stent expansion was defined as the ratio of measured to predicted minimum stent diameter. There was a trend for lower stent expansion in the Cypher Select stent group (0.74 +/- 0.08 vs 0.78 +/- 0.11 in the Taxus Express-2 stent group, p = 0.061). Cypher Select stents achieved a final minimal stent cross-sectional area of 5.5 +/- 1. 8 mm2, compared with 6.4 +/- 1.9 mm2 for Taxus Express-2 stents (p = 0.015). For stents with nominal diameters > or =2.75 mm (Cypher Select n = 40, Taxus Express-2 n = 38), 42.5% of the Cypher Select stents and 10.5% of the Taxus Express-2 stents did not achieve a final minimum stent area of 5 mm2 (p = 0.002). Insulin treatment (relative risk 0.31, 95% confidence interval 0.10 to 0.95, p = 0.041) and stent type (relative risk 0.15, 95% CI 0.04 to 0.53, p = 0.003) were independent predictors of not achieving a minimum stent area >5.0 mm2. In conclusion, an important percentage of DES in patients with diabetes fail to achieve the manufacturers' predicted final minimal stent diameter. Cypher Select stent and insulin treatment were independent predictors of not achieving a minimum stent area >5.0 mm2.
Jensen
Lisette Okkels
LO
Department of Cardiology, Odense University Hospital, Odense, Denmark. okkels@dadlnet.dk <okkels@dadlnet.dk>
Maeng
Michael
M
Mintz
Gary S
GS
Christiansen
Evald Hoej
EH
Hansen
Knud Noerregaard
KN
Galloe
Anders
A
Kelbaek
Henning
H
Hansen
Henrik Steen
HS
Joergensen
Erik
E
Lassen
Jens Flensted
JF
Thuesen
Leif
L
Thayssen
Per
P
D000368:Aged; D023903:Coronary Restenosis / Q000000981:diagnostic imaging* / Q000517:prevention & control; D003920:Diabetes Mellitus; D003925:Diabetic Angiopathies; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D012307:Risk Factors; D020123:Sirolimus / Q000008:administration & dosage; D018084:Ultrasonography, Interventional
D007166:Immunosuppressive Agents; D017239:Paclitaxel; D020123:Sirolimus