Relationship between insight and neurocognition in patients with bipolar I disorder in remission.
The aim of this study was to examine the relationships between insight and neurocognition in a population of patients with bipolar I disorder who were in a remitted state. Using the Schedule of Assessment of Insight (SAI) and its expanded version, we evaluated 96 patients with bipolar I disorder in remission to determine their level of insight. We also evaluated their neurocognitive function included in the domains of executive function, attention, and memory. The associations between insight and neurocognitive function were examined by using the stepwise multiple regression analysis to control the confounding effects of sociodemographic and clinical factors. The results indicated that by controlling the confounding effects of other factors, executive function was positively associated with the SAI dimensions of awareness of illness and relabeling of phenomena, and the total expanded version of the SAI in remitted bipolar patients. The results of this study indicated that the relationships vary between different dimensions of insight and domains of neurocognitive function in remitted bipolar patients.
Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City 807, Taiwan.
Cheng-Fang
CF
Yen
Chung-Ping
CP
Cheng
Chih-Hung
CH
Ko
Ju-Yu
JY
Yen
Chi-Fen
CF
Huang
Cheng-Sheng
CS
Chen
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D018692:Antimanic Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001288:Attention; D001364:Awareness; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology*; D005260:Female; D006801:Humans; D018020:Lithium Compounds / Q000627:therapeutic use; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011340:Problem Solving; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011594:Psychometrics / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D014635:Valproic Acid / Q000627:therapeutic use; D014888:Wechsler Scales / Q000706:statistics & numerical data
D000927:Anticonvulsants; D018692:Antimanic Agents; D014150:Antipsychotic Agents; D018020:Lithium Compounds; D014635:Valproic Acid