[Shift in the content of immune cytokines in heart of mice under acoustic stress conditions and delta-sleep inducing peptide application].
Quantitative shifts in the content of interleukine-1, -2 and -6 of the myocardium of mice under the conditions of acoustic stress and delta-sleep inducing peptide action are studied. It has been shown that injection of delta-sleep inducing peptide has no effect on the level of interleukine-1 and -2 in the myocardial tissue, whereas the quantity of interleukine-6 increased. The level of interleukine-1- and -6 in the myocardium were increased and no significant changes were observed in the level of interleukine-2 under the noise action. Interleukine-1- and -2 were not detected in the hypophysis of experimental animals of all groups (intact, under acoustic stress, under delta-sleep inducing peptide application). The level of interleukine-6 in the hypothalamus decreased under conditions of acoustic stress, whereas administration of delta-sleep inducing peptide has no effect on its level. The obtained data are considered in the context of immune modulating properties of delta-sleep inducing peptide.
Aĭvazian
L M
LM
Zakharian
G V
GV
Melkonian
M M
MM
D000818:Animals; D003701:Delta Sleep-Inducing Peptide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006333:Heart Failure / Q000276:immunology*; D007375:Interleukin-1 / Q000276:immunology*; D007376:Interleukin-2 / Q000276:immunology*; D015850:Interleukin-6 / Q000276:immunology*; D051379:Mice; D009206:Myocardium / Q000276:immunology* / Q000378:metabolism*; D009622:Noise / Q000009:adverse effects*; D010902:Pituitary Gland / Q000276:immunology / Q000378:metabolism; D012894:Sleep Stages / Q000502:physiology*
D007375:Interleukin-1; D007376:Interleukin-2; D015850:Interleukin-6; D003701:Delta Sleep-Inducing Peptide