Designed metal-binding sites in biomolecular and bioinorganic interactions.
The design of metal-binding functionality in proteins is expanding into many different areas with a wide range of practical and research applications. Here we review several developing areas of metal-related protein design, including the use of metals to induce protein-protein interactions or facilitate the assembly of extended nanostructures; the design of metallopeptides that bind metal and other inorganic surfaces, an area with potential in diverse applications ranging from nanoelectronics and photonics to biotechnology and biomedicine; and, the creation of sensitive and selective metal sensors for use both in vivo and in vitro.
Matthews
Jacqueline M
JM
School of Molecular and Microbial Biosciences, The University of Sydney, NSW 2006, Australia. j.matthews@usyd.edu.au
Loughlin
Fionna E
FE
Mackay
Joel P
JP
D001665:Binding Sites; D008670:Metals / Q000378:metabolism*; D008958:Models, Molecular; D011506:Proteins / Q000378:metabolism
D008670:Metals; D011506:Proteins