Substance P and NK1 receptor expression in the enteric nervous system is related to the development of chagasic megacolon.
Chagasic megacolon is one of the most important forms of Chagas disease. This form is characterized by inflammation, neuronal destruction and organ dilatation. The aim of this study is to characterize the expression of substance P and its main receptor, NK1 receptor, in dilated and non-dilated samples of colon from chagasic patients with megacolon. Our results demonstrate that dilated portions of colon present high levels of substance P and low levels of NK1 receptor, whereas non-dilated portions and samples from non-infected individuals present low levels of substance P and high levels of NK1 receptor. We believe that this may indicate a neuro-immune relationship that occurs in Chagas disease.
Research Center René Rachou, FIOCRUZ, Av. Augusto de Lima, 1715, Barro Preto, Belo Horizonte, MG, Brazil. alec@cpqrr.fiocruz.br
Alexandre B M
AB
da Silveira
Michelle A R
MA
Freitas
Enio C
EC
de Oliveira
Salustiano G
SG
Neto
Alejandro O
AO
Luquetti
John B
JB
Furness
Rodrigo
R
Correa-Oliveira
Débora d'Avila
Dd
Reis
D001938:Brazil; D014355:Chagas Disease / Q000209:etiology / Q000378:metabolism*; D017615:Enteric Nervous System / Q000378:metabolism*; D006801:Humans; D008531:Megacolon / Q000209:etiology*; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D012307:Risk Factors; D013373:Substance P / Q000378:metabolism*
D018040:Receptors, Neurokinin-1; D013373:Substance P