Is there a differential strength of specific HLA mismatches in kidney transplants?
In this article we attempted to identify whether there is a specific mismatched antigen that might be detrimental to kidney transplant outcome. The frequency of function versus failure of transplant cases was tallied within subpopulations among a subset of the 2006 United Network for Organ Sharing transplant dataset. We examined 7998 cadaveric and 11,420 living donor kidney transplants that were mismatched for a single class I antigen. When tested by five different criteria, the results were relatively similar for the HLA class I, A- and B-locus mismatches. HLA A1 was identified as the single most dominant immunogenic mismatch. However, when the P values were multiplied by 68, the number of comparisons, A1 was only marginally significant. We concluded that at least for class I specificities, the 68 specificities were about equal immunogenicity in kidney transplantation.
One Lambda Incorporated, Canoga Park, California, USA.
N
N
Sasaki
A
A
Idica
P
P
Terasaki
D002102:Cadaver; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology* / Q000706:statistics & numerical data; D019520:Living Donors / Q000706:statistics & numerical data*; D018579:Patient Selection; D013997:Time Factors; D014019:Tissue Donors / Q000706:statistics & numerical data*; D017211:Treatment Failure; D016896:Treatment Outcome
D006680:HLA Antigens