Combination dual responsive polypeptide vectors for enhanced gene delivery.
Variation in amino acid sequences on a disulfide-linked polypeptide backbone generates differing pK(a) vectors for DNA delivery, which release nucleic acids under reducing conditions and transfect cells with greater efficacy than non-reducible or non-variable pK(a) analogues.
School of Chemistry, University of Birmingham, UK. j.a.preece@bham.ac.uk
Rujikan
R
Nasanit
Parvez
P
Iqbal
Mahmoud
M
Soliman
Neil
N
Spencer
Stephanie
S
Allen
Martyn C
MC
Davies
Simon S
SS
Briggs
Leonard W
LW
Seymour
Jon A
JA
Preece
Cameron
C
Alexander
D004247:DNA / Q000737:chemistry / Q000648:ultrastructure; D004220:Disulfides / Q000737:chemistry; D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D018625:Microscopy, Atomic Force; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism
D004220:Disulfides; D010455:Peptides; D004247:DNA