Rewiring bacteria, two components at a time.
In this issue, Skerker et al. (2008) present a rational method for rewiring the protein-protein interactions and output responses of prokaryotic two-component signal transduction systems. This work has important implications for understanding the specificity of protein interactions and for designing protein-based synthetic signaling cascades.
Kohanski
Michael A
MA
Department of Biomedical Engineering, Center for BioDynamics, and Center for Advanced Biotechnology, Boston University, 44 Cummington St., Boston, MA 02215, USA.
Collins
James J
JJ
D001419:Bacteria / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015202:Protein Engineering; D015398:Signal Transduction
D001426:Bacterial Proteins