Facial cleft and associated anomalies: incidence among infants at a Jordanian medical centre.
To estimate incidence of cleft lip and cleft palate among Jordanian infants and to identify associated anomalies, we carried out a prospective, hospital-based study over a 5-year period, January 2000-January 2005. The total number of liveborn infants was 25 440, 60 of whom (2.4/1000) had facial clefts: 20 (33%) with cleft lip, 15 (25%) with cleft palate and 25 (42%) with both. Congenital heart disease was the commonest associated anomaly (47%) identified, followed by skeletal abnormalities (13%). Renal anomalies were found in 10% of cases. The high prevalence of congenital heart disease may justify routine echocardiography screening. The high consanguineous marriage rate may be a contributing factor to the high incidence of cleft anomalies.
Neonatal Unit, King Hussein Medical Centre, Amman, Jordan. h_aqrabawi@hotmail.com
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Aqrabawi
D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D000328:Adult; D002971:Cleft Lip / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D002972:Cleft Palate / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D003241:Consanguinity; D004452:Echocardiography; D016021:Epidemiologic Studies; D005260:Female; D020073:Gravidity; D006301:Health Services Needs and Demand; D006779:Hospitals, Public; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007597:Jordan / Q000453:epidemiology; D008297:Male; D015997:Neonatal Screening; D011159:Population Surveillance; D011247:Pregnancy; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D016216:Ultrasonography, Prenatal