Agelasines J, K, and L from the Solomon Islands Marine Sponge Agelas cf. mauritiana.
Three new diterpene alkaloids, agelasine J (3), agelasine K (4), and agelasine L (5), were isolated from the marine sponge Agelas cf. mauritiana collected in the Solomon Islands. The structures of these compounds were elucidated by physical data analyses. They displayed in vitro antimalarial activity against Plasmodium falciparum.
Appenzeller
Jérôme
J
Institut de Chimie des Substances Naturelles du CNRS, 91198 Gif-sur-YVette, France.
Mihci
Ghezala
G
Martin
Marie-Thérèse
MT
Gallard
Jean-François
JF
Menou
Jean-Louis
JL
Boury-Esnault
Nicole
N
Hooper
John
J
Petek
Sylvain
S
Chevalley
Severine
S
Valentin
Alexis
A
Zaparucha
Anne
A
Al-Mourabit
Ali
A
Debitus
Cécile
C
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013058:Mass Spectrometry; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D011161:Porifera
D000470:Alkaloids; D000962:Antimalarials; D004224:Diterpenes