Fibrillary glomerulonephritis with splenic involvement: a detailed autopsy study.
Fibrillary glomerulonephritis (FGN) is characterized by the deposition of IgG-positive, randomly arranged, nonbranching, non-Congophilic fibrils in the glomeruli. The possibility of multiorgan involvement, as in amyloidosis, has been raised. The authors report the first detailed autopsy study on a patient with FGN, with thorough examination of the organs by electron microscopy, colloidal gold immunoelectron microscopy, and immunofluorescence staining. Thin, wavy fibrils (extracellular matrix filaments) ranging from 6 to 17 nm were seen in all other organs, but only kidney and spleen showed the typical rigid, nonbranching fibrils of FGN with specific gold label. This study suggests that FGN is mainly a renal-limited disease with possible involvement of the spleen.
Satoskar
Anjali A
AA
Department of Pathology, The Ohio State University Medical Center, Columbus, Ohio 43210, USA.
Calomeni
Edward
E
Nadasdy
Gyongyi
G
Tozbikan
Gary
G
Hitchcock
Charles
C
Hebert
Lee
L
Nadasdy
Tibor
T
D001344:Autopsy; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D017979:Gold Colloid; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism; D007678:Kidney Glomerulus / Q000648:ultrastructure; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D013158:Splenic Diseases / Q000150:complications* / Q000473:pathology*
D017979:Gold Colloid; D007145:Immunoglobulin kappa-Chains; C058457:Aurodye