Characteristics of monozygotic male and female twins discordant for overweight: a descriptive study.
OBJECTIVE
BMI is highly heritable. Yet, trends in obesity highlight environmental influences on body weight. Monozygotic (MZ) twins discordant for overweight offer a unique opportunity to examine these factors.


METHODS
MZ male (n=8 pairs) and female twins (n=10 pairs) discordant for overweight (defined as the BMI of one twin being at least 24.5, and the BMI of his/her co-twin being below 24.5 and at least three points lower) were identified from the Mid-Atlantic Twin Registry. Variables were assessed via self-report questionnaires.


RESULTS
One overweight and two non-overweight females met criteria for bulimia nervosa. Rates of dieting and binge eating were high among all males and females. Hunger scores were higher among non-overweight females; disinhibition scores were higher among overweight males. Only one non-overweight and three overweight males smoked; 90% of non-overweight and 40% of overweight females smoked.


CONCLUSIONS
Assessing tobacco use and eating disorders may be important when sampling on the basis of family members who are discordant for BMI. Finally, results suggest possibilities for interventions in individuals at-risk for overweight.
Mitchell
Karen S
KS
Virginia Institute for Psychiatric & Behavioral Genetics, Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284-2018, USA. s2ksmitc@vcu.edu
Mazzeo
Suzanne E
SE
Aggen
Steven H
SH
Maes
Hermine H
HH
Kendler
Kenneth S
KS
Neale
Michael C
MC
Bulik
Cynthia M
CM
D001724:Birth Weight; D015992:Body Mass Index; D031204:Caloric Restriction; D004200:Diseases in Twins / Q000235:genetics* / Q000523:psychology; D004777:Environment; D001068:Feeding and Eating Disorders / Q000235:genetics* / Q000523:psychology; D005260:Female; D006801:Humans; D006815:Hunger; D008297:Male; D050177:Overweight / Q000235:genetics* / Q000523:psychology; D010551:Personality; D012042:Registries; D012307:Risk Factors; D012907:Smoking; D011795:Surveys and Questionnaires; D014430:Twins, Monozygotic / Q000235:genetics* / Q000523:psychology