Bone morphogenetic protein 7 (BMP7): a critical role in kidney development and a putative modulator of kidney injury.
Bone morphogenetic protein 7 (BMP7), a member of the tumor growth factor beta superfamily, appears to have a role in both kidney development and response to kidney injury. Signals through its pathways permit both epithelial differentiation during embryogenesis and preservation of normal kidney architecture after stress, leading to the hypothesis that BMP7 may exert its kidney-protective effects in adult animals by preventing or reversing epithelial-to-mesenchymal transformation. This review attempts to synthesize the data supporting those conclusions and suggest some future areas of research.
Division of Nephrology and Hypertension, UNC Hospital, UNC Kidney Center, Chapel Hill, NC 27599-7155, USA. patrick_archdeacon@med.unc.edu
Patrick
P
Archdeacon
Randal K
RK
Detwiler
D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000502:physiology*; D004195:Disease Models, Animal; D007668:Kidney / Q000196:embryology* / Q000502:physiology*; D007674:Kidney Diseases / Q000503:physiopathology*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000502:physiology*
D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta