Lack of the serotonin transporter does not prevent mineralocorticoid hypertension in rat and mouse.
We hypothesized that lack of a functional serotonin transporter (SERT) would increase basal blood pressure and enhance the development of deoxycorticosterone acetate (DOCA)-salt hypertension compared to wild type (WT) controls. Mean arterial blood pressure was measured in WT and SERT knockout (KO) mice and rat models through radiotelemetry. Basal blood pressures were not different between respective WT and KO. Moreover, blood pressure elevated similarly (~50 mm Hg) in all strains given DOCA and salt. Thus, the lack of functional SERT did not prevent development of DOCA-salt induced hypertension or modify basal blood pressure significantly.
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824-1317, USA.
Wei
W
Ni
Huawei
H
Zhou
Jessica
J
Diaz
Dennis L
DL
Murphy
Joseph R
JR
Haywood
Stephanie W
SW
Watts
D000818:Animals; D001794:Blood Pressure / Q000235:genetics; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D003900:Desoxycorticosterone; D004195:Disease Models, Animal; D006973:Hypertension / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008901:Mineralocorticoids; D051381:Rats; D017208:Rats, Wistar; D050486:Serotonin Plasma Membrane Transport Proteins / Q000172:deficiency* / Q000235:genetics; D013686:Telemetry; D013997:Time Factors
D008901:Mineralocorticoids; D050486:Serotonin Plasma Membrane Transport Proteins; C493231:Slc6a4 protein, mouse; C493232:Slc6a4 protein, rat; D003900:Desoxycorticosterone