[Distribution of eosinophils at different stages of hepatic granuloma evolution in mice infected with Schistosoma mansoni].
In the present study, the distribution of eosinophils at different stages of the formation of hepatic granuloma in mice infected with Schistosoma mansoni was evaluated. From the results obtained, we suggest a new classification for the evolution of hepatic granuloma in mice, constructed from the phases described by other authors. In each phase, there is a different pattern of eosinophil distribution. In the exudative-necrotic phase, the eosinophils are concentrated in the periphery and center of the granuloma, and are scarce in the necrotic area; in the productive phase, the eosinophils are dispersed throughout the granuloma; and in the cure due to fibrosis phase, the eosinophils are concentrated in the periphery and center of the granuloma. Eosinophils were found in direct contact with the eggs at all stages of evolution of the granuloma. It was concluded that the dynamics of eosinophils have an important role in forming the granulomatous reaction of the host and in resolving the inflammatory process caused by the parasite egg, as well as adding new data regarding hepatic granuloma classification.
Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE.
Romero Antunes Barreto
RA
Lins
Carmelita Bezerra de Lima
CB
Cavalcanti
Jorge Luiz Silva
JL
Araújo-Filho
Mário Ribeiro de
MR
Melo-Júnior
Maria Elizabeth Cavalcante
ME
Chaves
D000818:Animals; D004195:Disease Models, Animal; D047150:Eosinophil Cationic Protein / Q000032:analysis; D047209:Eosinophil Peroxidase / Q000032:analysis; D004804:Eosinophils / Q000201:enzymology / Q000473:pathology*; D006099:Granuloma / Q000469:parasitology / Q000473:pathology*; D007150:Immunohistochemistry; D008109:Liver Diseases, Parasitic / Q000469:parasitology / Q000473:pathology*; D008297:Male; D051379:Mice; D009336:Necrosis; D012555:Schistosomiasis mansoni / Q000469:parasitology / Q000473:pathology*; D013997:Time Factors
D047209:Eosinophil Peroxidase; D047150:Eosinophil Cationic Protein