Protective effects of melatonin on oxidative-antioxidative balance and cataract formation in rats.
We investigated the effects of melatonin on cataract formation in rats exposed to selenite. We concluded that the imbalance between oxidants and antioxidants plays an important role in cataract formation and melatonin decreases cataract incidence in rats by increasing antioxidant activity.
Kiliç
Adil
A
Department of Ophthalmology, Faculty of Medicine, Yüzüncü Yil University, Van, Turkey. kilicadil@gmail.com
Selek
Sahbettin
S
Erel
Ozcan
O
Aksoy
Nurten
N
D000818:Animals; D000831:Animals, Newborn; D000975:Antioxidants / Q000627:therapeutic use*; D043303:Aryldialkylphosphatase / Q000378:metabolism; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002386:Cataract / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite
D000975:Antioxidants; D002374:Catalase; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; D018038:Sodium Selenite; D008550:Melatonin