FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome.
The FTO (Fat mass and obesity associated) locus has recently been associated with obesity and type 2 diabetes (T2D) in humans. To understand the role of the FTO gene in polycystic ovary syndrome (PCOS) we genotyped single nucleotide polymorphism (SNP) rs1421085 (C/T) in women with PCOS (n=207) and controls (n=100) from a Central European population. The homozygous C/C genotype showed increased prevalence in PCOS patients either obese or with metabolic syndrome (MetS) compared to lean PCOS patients or controls (27.6%, 38.9%, 22.3%, and 16.3%, respectively). In logistic regression, this genotype strongly associated with MetS (P<0.0001, OR 3.2, 95% CI 1.8-5.7) and impaired fasting glucose (IFG) with P<0.0007, OR 7.7, 95% CI 2.1-28.6, independently of BMI or age, and to AUC(gluc) during OGTT (P<0.0001, alpha=0.99), indicating an influential role of the FTO gene in the glucose intolerance component of MetS.
Molecular Endocrinology Laboratory, IURC, 641 Avenue du Doyen Gaston Giraud, 34093 Montpellier Cedex 5, France.
Redha
R
Attaoua
Samira
S
Ait El Mkadem
Serban
S
Radian
Simona
S
Fica
Felicia
F
Hanzu
Alice
A
Albu
Monica
M
Gheorghiu
Mihai
M
Coculescu
Florin
F
Grigorescu
D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D016022:Case-Control Studies; D005215:Fasting; D005260:Female; D005838:Genotype; D005947:Glucose / Q000378:metabolism; D018149:Glucose Intolerance / Q000150:complications / Q000235:genetics; D006720:Homozygote; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications / Q000235:genetics*; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*
D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human; D005947:Glucose