The safety of baclofen in pregnancy: intrathecal therapy in multiple sclerosis.
Intrathecal baclofen is a GABA-receptor agonist and one of the mainstay treatments of severe spasticity due to multiple sclerosis (MS). The authors report a case on the use of intrathecal baclofen administered using a Medtronic Synchromed II infusion pump. A healthy male infant (2.68 kg, Apgars 9 and 10) was born at 36 weeks gestation by cesarean section, under general anesthetic. This is the fifth reported case of intrathecal baclofen administered during pregnancy and adds to the knowledge that thus far it is relatively safe in pregnancy and may in fact be safer for the infant than oral baclofen. This is the first case report of the use of intrathecal baclofen in pregnancy and MS.
National Hospital for Neurology and Neurosurgery, Queen Square, London WC1 N3BG, UK. catherine.dalton@uclh.nhs.uk
Catherine M
CM
Dalton
Elizabeth
E
Keenan
Louise
L
Jarrett
Lisa
L
Buckley
Valerie L
VL
Stevenson
D000328:Adult; D001418:Baclofen / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D018755:GABA Agonists / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007231:Infant, Newborn; D007278:Injections, Spinal; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome
D018755:GABA Agonists; D001418:Baclofen