Natural compounds: leads or ideas? Bioinspired molecules for drug discovery.
In this article, we compare drugs of natural origin to synthetic compounds and analyze the reasons why natural compounds occupy a place of choice in the current pharmacopoeia. The observations reported here support the design of synthetic compounds inspired from plant alkaloids and their biosynthetic pathway. Our reasoning leads to very efficient syntheses of compounds which complexity matches that of indolomonoterpenic alkaloids.
Beghyn
Terence
T
INSERM U761, Biostructures and Drug Discovery, Lille, F-59006, France.
Deprez-Poulain
Rebecca
R
Willand
Nicolas
N
Folleas
Benoit
B
Deprez
Benoit
B
D000470:Alkaloids / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry* / Q000627:therapeutic use; D015195:Drug Design; D010936:Plant Extracts / Q000737:chemistry; D013329:Structure-Activity Relationship
D000470:Alkaloids; D001688:Biological Products; D010936:Plant Extracts