Measurement of oxygen saturation in the retina with a spectroscopic sensitive multi aperture camera.
We introduce a new multi aperture system capable of capturing six identical images of the human fundus at six different spectral bands. The system is based on a lenslet array architecture and is well suited for spectroscopy application. The multi-aperture system was interfaced with a fundus camera to acquire spectroscopic sensitive images of the retina vessel and ultimately to calculate oxygen saturation in the retina in vivo. In vitro testing showed that the system is able to accurately reconstruct curves of partially oxygenated hemoglobin. In vivo testing on healthy volunteers was conducted and yielded results of oxygen saturation similar to the one reported in the literature, with arterial SO(2) approximately 0.95 and venous SO(2) approximately 0.5.
Ramella-Roman
Jessica C
JC
The Catholic University of America, Washington, D.C., USA. ramella@cua.edu
Mathews
Scott A
SA
Kandimalla
Haryipriya
H
Nabili
Afshin
A
Duncan
Donald D
DD
D'Anna
Salvatore A
SA
Shah
Syed Mahmood
SM
Nguyen
Quan Dong
QD
D002138:Calibration; D005654:Fundus Oculi; D006454:Hemoglobins; D006801:Humans; D008543:Melanins / Q000378:metabolism; D009010:Monte Carlo Method; D010100:Oxygen / Q000378:metabolism*; D012160:Retina / Q000378:metabolism*; D012171:Retinal Vessels / Q000378:metabolism; D013057:Spectrum Analysis / Q000379:methods*; D014867:Water
D006454:Hemoglobins; D008543:Melanins; D014867:Water; D010100:Oxygen