Highly efficient stereocontrolled synthesis of Danishefsky's taxol CD ring key intermediate.
Danishefsky's taxol CD ring key intermediate is synthesized in 15 steps and 11.4% overall yield from a readily available starting material. Absolute stereochemistry of the starting material and stereocontrolled steps determine the absolute configuration of the five requisite contiguous stereocenters.
Université Paul Cézanne, Institut des Sciences Moléculaires de Marseille (ISM2), UMR-CNRS-6263, Equipe STéRéO Campus Scientifique de Saint-Jérôme, Case 541 13397 Marseille Cedex 20, France.
Paul
P
Brémond
Gérard
G
Audran
Honoré
H
Monti
D000077143:Docetaxel; D015394:Molecular Structure; D017239:Paclitaxel / Q000138:chemical synthesis* / Q000737:chemistry; D020005:Propanols / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D043823:Taxoids / Q000737:chemistry
D020005:Propanols; D043823:Taxoids; D000077143:Docetaxel; C006463:allyl alcohol; D017239:Paclitaxel