Resorbable scaffolds from three different techniques: electrospun fabrics, salt-leaching porous films, and smooth flat surfaces.
Nanofibrous scaffolds of poly[(L-lactide)-co-(1,5-dioxepan-2-one)] generated by electrospinning have been compared with porous films obtained by solvent cast/salt leaching and homogeneous films. A comparison between the fibrous materials and the homogeneous solvent-cast films revealed that the surface of the nanofibers was more hydrophobic and that the nanofibers were degraded more rapidly in the presence of proteinase. It was obvious that the strain-to-break was reduced by the nanofiber formation, it decreased from 370% to 130% independent of fiber diameter. These values were however considerably higher than the strain-to-break of the solvent-cast/salt leaching scaffold. In addition, the nanofibrous material accelerated the adhesion and growth of the mesenchymal stem cell compared to the smooth material.
Department of Fibre and Polymer Technology, Royal Institute of Technology, SE-100 44 Stockholm, Sweden.
Anna
A
Finne-Wistrand
Ann-Christine
AC
Albertsson
Oh Hyeong
OH
Kwon
Naoki
N
Kawazoe
Guoping
G
Chen
Inn-Kyu
IK
Kang
Hirokazu
H
Hasuda
Jiansheng
J
Gong
Yoshihiro
Y
Ito
D002448:Cell Adhesion; D002452:Cell Count; D049109:Cell Proliferation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000648:ultrastructure; D049329:Nanostructures / Q000648:ultrastructure; D011108:Polymers / Q000737:chemistry; D016062:Porosity; D012492:Salts / Q000737:chemistry*; D012996:Solutions; D013499:Surface Properties; D054457:Tissue Scaffolds / Q000737:chemistry*
D011108:Polymers; D012492:Salts; D012996:Solutions