Solubilizing and lithogenolitic properties of water solutions of non-ionic surfactants of cholesterol oxyethylenation products.
Research was conducted into the properties and identity of the products oxyethylenation of cholesterol, which were obtained with the use of a selective catalyst (K-4) and standard alkaline catalyst (Na/NaOH). The 1HNMR method was employed to assess the content of oxyethylated segments and the analytic level of hydrophilic--lipophilic balance (HLB). Basic viscosity and hydrodynamic values were determined for the solubilizers and their micellar adduct with ibuprofen, ketoprofen, naproxen and cholesterol. In addition, the amount of solubilized therapeutic agents and cholesterol as well as the micellar partition coefficient--K(m)w. was estimated. The results obtained in the course of research served as a basis for determining the solubilization mechanism and the stability of the micellar adduct for the purpose of application.
Department of Technology of Dosage Forms, Chair of Applied Pharmacy, Medical University of Lodz. mmzgoda@pharm.am.lodz.pl
Marian Mikołaj
MM
Zgoda
Michał Jakub
MJ
Nachajski
Michal Krzysztof
MK
Kołodziejczyk
Marcin Hubert
MH
Woskowicz
Marek
M
Lukosek
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D002384:Catalysis; D002784:Cholesterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D005027:Ethylene Oxide / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry; D007477:Ions; D007660:Ketoprofen; D020347:Lithiasis / Q000139:chemically induced; D008823:Micelles; D008962:Models, Theoretical; D009288:Naproxen / Q000737:chemistry; D012995:Solubility; D012996:Solutions / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology*; D014867:Water / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007477:Ions; D008823:Micelles; D012996:Solutions; D013501:Surface-Active Agents; D014867:Water; D009288:Naproxen; D007660:Ketoprofen; D002784:Cholesterol; D005027:Ethylene Oxide; D007052:Ibuprofen