Therapeutic angiogenesis: a new treatment approach for ischemic heart disease--part I.
Angiogenesis is the biologic process of forming new blood vessels and is being investigated as an innovative therapeutic approach to help manage ischemic heart disease and peripheral vascular disease. Research studies have identified various angiogenic growth factors and progenitor cells that can enhance new blood vessel formation. Preclinical investigations in animal models have explored the potential use of growth factors with and without progenitor cells to treat myocardial ischemia. The results of clinical trials with growth factor infusions and gene therapy techniques to enhance growth factor production have shown some promise, but therapeutic angiogenesis remains at an early stage of development.
Ahn
Anna
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Department of Medicine, Long Island Jewish Medical Center/Albert Einstein College of Medicine, New Hyde Park, New York, USA.
Frishman
William H
WH
Gutwein
Andrew
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Passeri
Jonathan
J
Nelson
Michael
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D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000818:Animals; D003324:Coronary Artery Disease / Q000628:therapy; D003331:Coronary Vessels / Q000187:drug effects*; D019317:Evidence-Based Medicine; D015316:Genetic Therapy / Q000379:methods; D006133:Growth Substances / Q000627:therapeutic use; D006801:Humans; D017202:Myocardial Ischemia / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D016896:Treatment Outcome; D042442:Vascular Endothelial Growth Factors / Q000494:pharmacology / Q000627:therapeutic use
D043925:Angiogenesis Inducing Agents; D006133:Growth Substances; D042442:Vascular Endothelial Growth Factors