[Fosfomycin prescription during production shortage].
The supply of fosfomycin had to be carefully controlled over metropolitan France during 10 weeks because of a unique crisis in production. Three hundred and forty prescriptions were collected and re-examined by an expert committee. The main indications were osteoarthritis (27%), lung infections (21%), severe sepsis (12.5%), and urinary tract infections (11%). The main bacteria involved, often multidrug resistant, were Pseudomonas aeruginosa (40%) and methicillin-resistant Staphylococcus. A careful analysis of the antibiogram proved fosfomycin to be irreplaceable in 36% of the cases. This study confirms and specifies the interest of fosfomycin. To our knowledge, this study was a unique opportunity to collect such specific data from the whole of France over a two-month shortage period.
Service des maladies infectieuses et tropicales, hôpital Raymond-Poincaré, AP-HP, université de Versailles-Saint-Quentin-en-Yvelines, 104, boulevard Raymond-Poincaré, 92380 Garches, France.
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A
Dinh
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JP
Bru
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I
Dresco
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C
Janus
L
L
Bernard
D000890:Anti-Infective Agents / Q000627:therapeutic use*; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D004865:Equipment and Supplies, Hospital / Q000706:statistics & numerical data*; D005578:Fosfomycin / Q000627:therapeutic use*; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy; D008507:Medically Underserved Area; D016106:Methicillin Resistance; D010003:Osteoarthritis / Q000188:drug therapy; D018805:Sepsis / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy
D000890:Anti-Infective Agents; D005578:Fosfomycin