Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea.
Eight new sesquiterpenoids, named populene A-H (1-8), were isolated from dichloromethane extracts of the wood and dark heartwood of Thespesia populnea, together with 11 known compounds (9-19). Their structures were determined on the basis of spectroscopic analyses. The cytotoxic activity of isolated compounds was evaluated against four cancer cell lines: MCF-7, HeLa, HT-29, and KB. Mansonone E (11) and (+)-gossypol (18) showed significant activities. Their antibacterial properties against Bacillus subtilis, Staphylococcus aureus, and Enterococcus faecalis are also presented.
Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
Sompong
S
Boonsri
Chatchanok
C
Karalai
Chanita
C
Ponglimanont
Suchada
S
Chantrapromma
Akkharawit
A
Kanjana-Opas
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D013293:Enterococcus faecalis / Q000187:drug effects; D006072:Gossypol / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D019660:Malvaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013785:Thailand; D014934:Wood / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D009285:Naphthoquinones; D012717:Sesquiterpenes; C496164:mansonone E; D006072:Gossypol