Tat-3L4F does not significantly affect spatial learning and memory.
We recently found that the interfering peptide Tat-3L4F is able not only to disrupt the protein-protein interaction of PTEN (phosphatase and tensin homologue deleted on chromosome 10) with the serotonin 5-HT2C receptor in the rat ventral tegmental area (VTA) but also to suppress the conditioned place preference induced by cannabinoid and nicotine without significant effects on anxiety, feeding behavior and motor activity. It is unknown, however, whether Tat-3L4F affects learning and memory. Using a Morris water maze test, we show here that while the cannabinoid HU210 significantly inhibited the performance of spatial learning without significant effects on long-term memory, Tat-3L4F did not induce significant effects on the acquisition and retrieval of spatial memory. These results indicate that Tat-3L4F can suppress the rewarding effects of abused drugs without significant effects on learning and memory.
Institute of Mental Health Research and Departments of Psychiatry and Cellular & Molecular Medicine, 1145 Carling Avenue, Ottawa, Ontario, Canada K1Z7K4.
Xuesheng
X
Li
Yun
Y
Zhang
Xia
X
Zhang
D000818:Animals; D002186:Cannabinoids / Q000008:administration & dosage / Q000494:pharmacology; D013759:Dronabinol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D010446:Peptide Fragments / Q000737:chemistry / Q000235:genetics; D051381:Rats; D020318:Rats, Long-Evans; D044405:Receptor, Serotonin, 5-HT2C / Q000737:chemistry; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D013028:Space Perception / Q000187:drug effects / Q000502:physiology; D013037:Spatial Behavior / Q000187:drug effects* / Q000502:physiology; D054322:tat Gene Products, Human Immunodeficiency Virus / Q000737:chemistry
D002186:Cannabinoids; D010446:Peptide Fragments; D044405:Receptor, Serotonin, 5-HT2C; D011993:Recombinant Fusion Proteins; C532629:Tat-3L4F peptide; D054322:tat Gene Products, Human Immunodeficiency Virus; D013759:Dronabinol; C062018:HU 211