Prolonged survival after multifocal brain radiation necrosis associated with whole brain radiation for brain metastases: case report.
Radiation necrosis of the brain is a well documented adverse effect of radiation therapy. The authors report an unusual case of relapsing multifocal radiation necrosis following whole brain radiation therapy (WBRT) for brain metastases from a systemic germ cell tumor. Anticoagulation with warfarin may have had therapeutic benefit. The patient is alive without a neurological deficit 10 years after the diagnosis of radiation necrosis.
Department of Neurology, Henry Ford Health System, Detroit, MI, USA. mirela@neuro.hfh.edu
Mirela
M
Cerghet
Bruce
B
Redman
Larry
L
Junck
Jeffrey
J
Forman
Lisa R
LR
Rogers
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D009336:Necrosis; D009373:Neoplasms, Germ Cell and Embryonal / Q000532:radiotherapy* / Q000556:secondary*; D019635:Neurosurgical Procedures; D011832:Radiation Injuries / Q000473:pathology*; D013736:Testicular Neoplasms / Q000473:pathology