The macrokinetics of an enzymatic system containing an enzyme that inactivates in the course of reaction.
The work describes the action of a heterogenous multisubstrate enzymatic system under conditions involving inactivation of the enzyme. A nonsteady-state kinetic model has been suggested for description of the system. It has been found that the time dependence of the product flow from the membrane is a curve with a maximum which falls on a time equal to the reverse inactivation constant. It has been shown that the efficiency of such systems increases as does the time of the operation of the enzyme.
Sud'ina
G F
GF
Moscow State University, Moscow 117234, USSR.
Kobel'kov
G M
GM
Varfolomeev
S D
SD