Hybridization energies of double strands composed of DNA, RNA, PNA and LNA.
The electronic properties of double strands composed of trimeric LNA, PNA, DNA and RNA single strands were investigated by density-functional molecular orbital calculations. The computed hybridization energies for the double strands involving PNA or LNA are larger than those for DNA-DNA and RNA-RNA. The larger stability is attributed to the presence of a larger positive charge of the hydrogen atoms contributing to the hydrogen bonds in the PNA-DNA and LNA-DNA double-strands. These results are comparable to the experimental finding that PNA and LNA single strands display high affinity toward a complementary DNA or RNA single strand.
Department of Knowledge-based Information Engineering, Toyohashi University of Technology, Tenpaku-cho, Toyohashi 441-8580, Japan.
Takayuki
T
Natsume
Yasuyuki
Y
Ishikawa
Kenichi
K
Dedachi
Takayuki
T
Tsukamoto
Noriyuki
N
Kurita