Abnormal glucose regulation in an Australian acute coronary syndrome population: a prospective study.
BACKGROUND
Abnormal glucose regulation (AGR) is common and an adverse risk factor in patients presenting with acute coronary syndromes (ACS).


METHODS
We prospectively evaluated the prevalence of AGR in 300 ACS patients. Fasting blood glucose (BGL), glycated haemoglobin (HbA1c) and urinary albumin creatinine ratio (ACR) were performed. Patients without diabetes completed an oral glucose tolerance test (OGTT) >or=4 weeks post-discharge.


RESULTS
On admission, AGR prevalence was 60%; 32% (n=94) with diabetes and 28% (n=83) with IFG. OGTT completed in 157 patients, detected new diabetes in 5% (n=8), IGT in 24% (n=37), and IFG in 6% (n=10). In 91 patients with normal admission fasting BGL, 25% (n=23) had AGR on OGTT. Conversely, in 62 patients with admission IFG, 50% (n=31) had a normal OGTT. Patients with versus those without AGR on OGTT had higher adjusted geometric mean HbA1c (5.92; 95% CI 5.81-6.02 vs. 5.66; 95% CI, 5.59-5.74, P=0.001) and urinary ACR (1.38; 95% CI, 0.99-1.91 vs. 0.74; 95% CI, 0.58-0.94, P=0.003) levels.


CONCLUSIONS
AGR is present in the majority of ACS patients and unrecognised in up to half of cases. OGTT improves the detection of AGR.
Department of Cardiovascular Medicine, Sir Charles Gairdner Hospital, Australia. s.chih@victorchang.edu.au
Sharon
S
Chih
Brendan M
BM
McQuillan
Joey
J
Kaye
John P
JP
Beilby
Joseph
J
Hung
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000150:complications; D000368:Aged; D000419:Albuminuria; D001315:Australia; D001786:Blood Glucose / Q000378:metabolism*; D003327:Coronary Disease / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D003404:Creatinine; D006442:Glycated Hemoglobin; D008055:Lipids