Regulation of mitochondrial antiviral signaling pathways.
Mitochondrial antiviral immunity involves the detection of viral RNA by intracellular pattern-recognition receptors (PRRs) belonging to the RIG-I-like helicase family. The convergence of these and other signaling molecules to the outer mitochondrial membrane results in the rapid induction of antiviral cytokines including type-1 interferon. Here, we discuss recent studies describing new molecules implicated in the regulation of this antiviral response.
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. cbmoore2@med.unc.edu
Chris B
CB
Moore
Jenny P-Y
JP
Ting
D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007370:Interferon Type I / Q000276:immunology / Q000378:metabolism; D008928:Mitochondria / Q000276:immunology / Q000378:metabolism*; D020365:RNA Helicases / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism*; D051192:Receptors, Pattern Recognition / Q000378:metabolism*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism; D014780:Viruses / Q000276:immunology*
D048868:Adaptor Proteins, Signal Transducing; D016207:Cytokines; D007370:Interferon Type I; C505371:MAVS protein, human; D012367:RNA, Viral; D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors; D020365:RNA Helicases