Mechanistic insights into glycosidase chemistry.
The enzymatic hydrolysis of the glycosidic bond continues to gain importance, reflecting the critically important roles complex glycans play in health and disease as well as the rekindled interest in enzymatic biomass conversion. Recent advances include the broadening of our understanding of enzyme reaction coordinates, through both computational and structural studies, improved understanding of enzyme inhibition through transition state mimicry and fascinating insights into mechanism yielded by physical organic chemistry approaches.
Vocadlo
David J
DJ
Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, V5A 1S6, Canada. dvocadlo@sfu.ca
Davies
Gideon J
GJ
D000818:Animals; D055162:Biocatalysis; D004791:Enzyme Inhibitors / Q000737:chemistry; D006026:Glycoside Hydrolases / Q000737:chemistry* / Q000378:metabolism*; D006027:Glycosides / Q000378:metabolism; D006801:Humans; D011487:Protein Conformation; D013379:Substrate Specificity
D004791:Enzyme Inhibitors; D006027:Glycosides; D006026:Glycoside Hydrolases