Virtual high throughput screening (vHTS) on an optical high speed testbed.
Malaria remains a global health concern, which kills over a million people each year. In this paper we present work extending the approach of the WISDOM initiative by focusing on the problems noticed during the first WISDOM challenge against malaria and test the newly established, high bandwidth optical Grid environment VIOLA for advanced bioinformatics applications using the UNICORE middleware service. In addition we present an approach to reduce the size of the compound database to improve the efficiency of the screening.
Fraunhofer Institute SCAI, Department of Bioinformatics, Germany.
Mohammad
M
Shahid
Wolfgang
W
Ziegler
Vinod
V
Kasam
Marc
M
Zimmermann
Martin
M
Hofmann-Apitius
D019295:Computational Biology / Q000458:organization & administration*; D003199:Computer Systems; D019992:Databases as Topic; D005858:Germany; D006801:Humans; D008288:Malaria; D008492:Medical Informatics Computing; D014584:User-Computer Interface