Effect of contrast media formulation on computed tomography angiographic contrast enhancement.
The characteristics of contrast media formulation (mgI/ml, osmolarity, and viscosity) are generally not considered important in computed tomography (CT) angiography in animals. The purpose of this study was to assess the contrast effect in CT angiography as a function of contrast media formulation, with a constant iodine dose. The contrast effects of three contrast media with different iodine concentrations were compared by administering identical iodine dosages (mgI/kg). The contrast effects of the three contrast media differed, and the area under the time-attenuation curve of iohexol 350 mgI/ml, which had the highest iodine concentration, was the lowest. It was hypothesized that the contrast effect of a contrast medium decreases with higher iodine concentration because of the high amount of residual iodine present in the circulatory system from the injection site to the portion immediately before the great vessels. In addition, the influence of osmotic dilution on contrast media with high osmolarity was also considered. In conclusion, the contrast effect varies with different contrast media formulations, even when the same iodine dosage is administered.
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-Sen 11, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.
Miori
M
Kishimoto
Kazutaka
K
Yamada
Ryo
R
Tsuneda
Junichiro
J
Shimizu
Toshiroh
T
Iwasaki
Yoh-Ichi
Y
Miyake
D000792:Angiography / Q000295:instrumentation / Q000379:methods / Q000662:veterinary*; D000818:Animals; D019540:Area Under Curve; D003287:Contrast Media / Q000008:administration & dosage*; D018592:Cross-Over Studies; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000379:methods / Q000662:veterinary*; D007455:Iodine / Q000008:administration & dosage; D007472:Iohexol / Q000737:chemistry; D011897:Random Allocation; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000662:veterinary*
D003287:Contrast Media; D007472:Iohexol; D007455:Iodine