@neuLink: a service-oriented application for biomedical knowledge discovery.
We introduce the architecture of @neuLink, a service-oriented environment for biomedical knowledge discovery which has been developed in the course of EU Integrated Project @neurIST. The application integrates data from databases with information extracted from unstructured text sources. Moreover, @neuLink supports the analysis of primary biomolecular data associated with individual patients and thus enables the interpretation of molecular data inside a clinical research environment. Based on an assembly of data services, @neuLink interacts with the complex @neurIST grid infrastructure through a dedicated data access and data mediation service. Data types integrated by @neuLink are covering the entire span of biomolecular entities: from gene names in text to entries in EntrezGene; from mentions of drugs to Drugbank, from information on allelic variants in scientific literature to entries in dbSNP. The architecture of @neuLink allows easy integration of other webservice-based applications and thus the spectrum of analysis capabilities of @neuLink can be extended following the requirements of the users of the @neurIST system.
Friedrich
Christoph M
CM
Fraunhofer Institute for Algorithms and Scientific Computing, Schloss Birlinghoven, D-53754 St. Augustin, Germany. friedrich@scai.fraunhofer.de
Dach
Holger
H
Gattermayer
Tobias
T
Engelbrecht
Gerhard
G
Benkner
Siegfried
S
Hofmann-Apitius
Martin
M
D001185:Artificial Intelligence; D001317:Austria; D019295:Computational Biology / Q000379:methods / Q000458:organization & administration*; D003199:Computer Systems; D003628:Database Management Systems; D019992:Databases as Topic; D020000:Decision Support Systems, Clinical / Q000458:organization & administration*; D003661:Decision Support Techniques; D005062:European Union; D005858:Germany; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods; D008967:Molecular Biology / Q000458:organization & administration*