Incorporating the family as a critical context in genetic studies of children: implications for understanding pathways to risky behavior and substance use.
The availability of candidate gene markers for biobehavioral traits will undoubtedly result in increasing attention to genetic influences in studies of childhood risk factors for health behaviors. However, a strict emphasis on genomics without consideration of the social contexts that give rise to risky behaviors will miss opportunities to understand more fully the powerful effect of the family on childhood development. This article discusses the rationale for using the family as a critical context for studying the translation of genetic propensity for risky behavior into developmental pathways that span childhood and adolescence. Attention is given to the importance of family environmental factors; the emerging literature on genetic influences on potential intermediate phenotypes; the need for rich and detailed characterizations of both phenotypes and environmental risk factors embedded within genomic studies of children; and implications for interventions and preventions aimed at risky behaviors. Via discussion of these issues, pragmatic considerations of how studying families as a context may facilitate the thoughtful inclusion of children into genetic paradigms are emphasized.
Rende
Richard
R
Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, USA. richard_rende@brown.edu
Slomkowski
Cheryl
C
D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000235:genetics* / Q000523:psychology; D000987:Antisocial Personality Disorder / Q000235:genetics / Q000523:psychology; D002648:Child; D005195:Family Relations; D020022:Genetic Predisposition to Disease / Q000235:genetics* / Q000523:psychology; D005820:Genetic Testing / Q000523:psychology*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D015999:Multivariate Analysis; D010641:Phenotype; D012309:Risk-Taking; D012931:Social Environment; D019966:Substance-Related Disorders / Q000235:genetics* / Q000523:psychology