[Does new antihistamines characterize tachyphylaxis phenomenon?].
OBJECTIVE
was to estimate the skin microcirculation reactivity after histamine administration in patients treated with 10 mg daily dose of cetirizine for 180 days.


METHODS
Thirty seven young men age 27+12 year, patients suffering from persistent rhinitis were randomized into three groups which received 10 mg/day of cetirizine, 5 mg/day of levocetirizine or placebo respectively. Twenty eight completed the study. The skin microcirculation reaction after 10 mg/ml histamine administration was estimated visually on the forearm (diameter of wheal and flare) and by laser Doppler flowmetry before and after study drug or placebo administration 24 hours and every 30 days during the time of the study. The blood flow was measured by Periflux PF3, using a skin probe 5 mm away from the histamine-induced point.


RESULTS
Statistically significant inhibition of skin reaction (over 92%) and blood flow (over 85%) in relation to the start values in cetirizine group as well as between the groups which received cetirizine or placebo (p<0.001), remained at the same level all the time during the examination.


CONCLUSIONS
Tachyphylaxis phenomenon for antihistamine effect of 10 mg/day cetirizine and 5 mg/day levocetirizine was not observed during the whole 180-days treatment.
Kłos
Krzysztof
K
Klinika Chorób Infekcyjnych i Alergologii CSK MON Wojskowego Instytutu Medycznego w Warszawie.
Kruszewski
Jerzy
J
D000293:Adolescent; D000328:Adult; D017332:Cetirizine / Q000008:administration & dosage*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage*; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D012867:Skin / Q000098:blood supply* / Q000187:drug effects; D013618:Tachyphylaxis
D006634:Histamine H1 Antagonists; C472067:levocetirizine; D017332:Cetirizine