Platelet-derived microparticle levels in women with recurrent spontaneous abortion.
OBJECTIVE
To investigate the significance of platelet-derived microparticles (PMPs) in women with recurrent spontaneous abortion.


METHODS
We measured platelet P-selectin (CD62P) as a platelet activation marker and CD42b(+) microparticles as PMPs by flow cytometry in whole blood of 20 women with recurrent spontaneous abortion and 20 age-matched healthy controls with no previous history of spontaneous abortion.


RESULTS
PMP levels in women with recurrent spontaneous abortion were higher than in women in the control group (4.79+/-1.18% vs 3.06+/-0.92%; P<0.000). CD62P levels were not significantly higher in the study group compared with the control group (13.78+/-8.62% vs 10.78+/-7.35%; P>0.05).


CONCLUSIONS
Our findings suggest that PMPs may have a role in the pathogenesis of recurrent spontaneous abortion.
Department of Hematology, Gülhane Military Medical Academy, Ankara, Turkey. mkkaptan@hotmail.com
Kürşat
K
Kaptan
Cengiz
C
Beyan
Ahmet
A
Ifran
Aysel
A
Pekel
D000026:Abortion, Habitual / Q000097:blood*; D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D019007:P-Selectin / Q000097:blood*; D010865:Pilot Projects; D010976:Platelet Count; D011247:Pregnancy
D019007:P-Selectin