Synthesis, micellar properties, DNA binding and antimicrobial studies of some surfactant-cobalt(III) complexes.
A new class of surfactant-cobalt(III) complex ions of the type, cis-[Co(X)(2)(C(14)H(29)NH(2))Cl](2+) (where X=ethylenediamine (en), or 2,2'-bipyridyl (bpy), or 1,10-phenanthroline (phen)) and cis-[Co(trien)(C(14)H(29)NH(2))Cl](2+) (trien=triethylenetetramine) were synthesized and characterized by IR, NMR, UV-visible electronic absorption spectra, elemental analysis and metal analysis. The critical micelle concentration (CMC) values of these surfactant-cobalt(III) complexes in aqueous solution were obtained from conductance measurements. Specific conductivity data (at 298, 308, 318 and 328 K) served for the evaluation of the temperature-dependent CMC and the thermodynamics of micellization (DeltaG(0)(m), DeltaH(0)(m) and DeltaS(0)(m)). Interactions between calf thymus DNA and the surfactant-cobalt(III) complexes in aqueous solution have been investigated by electronic absorption spectroscopy, emission spectroscopy and viscosity measurements. The electrostatic interactions, van der Waals interactions and/or partial intercalative binding have been observed in these systems. The surfactant-cobalt(III) complexes were screened for their antibacterial and antifungal activities against various microorganisms. The results were compared with the standard drugs, Ciprofloxacin and Fluconazole respectively.
School of Chemistry, Bharathidasan University, Tiruchirappalli - 620 024, Tamil Nadu, India.
R Senthil
RS
Kumar
S
S
Arunachalam
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D002417:Cattle; D003035:Cobalt / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008823:Micelles; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D013057:Spectrum Analysis; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry*; D013816:Thermodynamics
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D008823:Micelles; D013501:Surface-Active Agents; D003035:Cobalt; D004247:DNA; C427203:calf thymus DNA