Age-dependent decrease in serum soluble interferon-gamma receptor (sIFN-gammaR) in healthy Japanese individuals; population study of serum sIFN-gammaR level in Japanese.
We planned to investigate the clinical significance of serum soluble interferon-gamma receptor (sIFN-gammaR) level in pediatric patients. The diagnostic application of the measurement of serum sIFN-gammaR level depends critically on the control value. However, there is no information of the control value of serum sIFN-gammaR for children. In the present study, we determined the serum sIFN-gammaR level of healthy Japanese children using an ELISA. The serum sIFN-gammaR level of children (0-14 years old) was significantly higher than that of adults (over 15 years old) (p < 0.01, n = 104). Thus, it is recommended that, when the serum sIFN-gammaR level of patients is evaluated, it should be compared against age-matched controls. We also preliminarily applied this assay as a diagnostic parameter for the patients with diarrhea positive (D+) hemolytic uremic syndrome (HUS).
Okamoto
Yoshihiro
Y
Laboratory of Immunology and Microbiology, Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan. yokamoto@cis.ac.jp
Seta
Kyoko
K
Nakajo
Izumi
I
Gotoh
Yoshimitsu
Y
Nagai
Takuhito
T
Fujita
Naoya
N
Fukui
Takashi
T
Masuzawa
Toshiyuki
T
D000293:Adolescent; D000328:Adult; D000375:Aging; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D017471:Receptors, Interferon / Q000097:blood*; D000096743:Interferon gamma Receptor
D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor