Rh(I)-catalyzed reaction of 2-(chloromethyl)phenylboronic acids and alkynes leading to indenes.
The reaction of 2-(chloromethyl)phenylboronic acid (1) with alkynes in the presence of a Rh(I) complex gave indene derivatives in high yields. The regioselectivity depends on the steric nature of the substituent on the alkynes. A bulky group favors the alpha-position of indenes.
Miyamoto
Masaki
M
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka, Japan.
Harada
Yasuyuki
Y
Tobisu
Mamoru
M
Chatani
Naoto
N