[Advances of studies on platelet additive solutions - review].
Platelet additive solutions (PAS) can partly or fully substitute blood plasma during platelet storage in normal air temperature. There are some advantages such as avoiding transfusion of large volume of plasma with possible adverse reactions and circulatory overload, saving plasma for other purposes, improving storage conditions, maintaining the viability and haemostatic function of platelet at normal level, and making it easy to inactivate pathogens. There has been an increasing interest in the study of PAS in the past 20 years, the compositions of different PAS have been reported one after another, and the protective effects of PAS on platelets have become better and better. This article focuses on the advances of studies of the composition of PAS, the functions of the different compositions and platelet quality in vitro and in vivo after storage.
Beijing Institute of Transfusion Medicine, Beijing 100850, China.
Wen-Bo
WB
Hu
Ying
Y
Han
D000085:Acetates / Q000494:pharmacology; D001792:Blood Platelets; D001793:Blood Preservation / Q000379:methods* / Q000639:trends; D002951:Citrates / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D017713:Platelet Transfusion / Q000009:adverse effects / Q000379:methods*
D000085:Acetates; D002951:Citrates; D005947:Glucose