Squamous cell abnormalities in exfoliated cells from the urine of Schistosoma haematobium-infected adults in a rural fishing community in Nigeria.
Schistosoma haematobium infection is endemic in Nigeria, with substantial transmissions in all the states of the federation and a high prevalence rate in schools. Literature has linked bladder cancer, mostly squamous cell type, with long-term S. haematobium infections. The objective of this descriptive study was to screen exfoliated cells in the urine of S. haematobium-infected patients for squamous cell abnormalities through cytopathological examinations. Study participants were drawn from Imala Odo, a community near Oyan Dam in Abeokuta North Local Government Area, Ogun state, Southwest Nigeria. Due to a considerable day-to-day variation of S. haematobium eggs in urine, 3 rounds of 200 ml of urine samples were collected on 3 different days from 32 infected patients and 10 uninfected controls and examined. Cytological preparations of the infected 15 males and 8 females and 10 controls (5 males and 5 females) were screened for squamous cell abnormalities. Severely dysplastic to frankly malignant squamous cells were observed in 1 (3.1%) male and 2 (6.3%) females, while no abnormality was observed in the controls.
Public Health Division, Nigerian Institute of Medical Research, P.M.B. 2013, Yaba, Lagos, Nigeria. pheabian@yahoo.ca.uk
O P
OP
Akinwale
G C
GC
Oliveira
M B
MB
Ajayi
D O
DO
Akande
S
S
Oyebadejo
K C
KC
Okereke
D000328:Adult; D000368:Aged; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000469:parasitology / Q000652:urine*; D005260:Female; D005399:Fishes / Q000469:parasitology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D012424:Rural Population; D012553:Schistosomiasis haematobia / Q000453:epidemiology / Q000652:urine*; D001749:Urinary Bladder Neoplasms / Q000469:parasitology / Q000652:urine*