Diversity-oriented synthesis.
Diversity-oriented synthesis (DOS), which describes the synthesis of structurally diverse collections of small molecules, was developed, in part, to address combinatorial chemistry's shortfalls. In this paper, we hope to give an indication of what can be achieved using the DOS approach to library generation. We describe some of the most successful strategies utilized in DOS, with special focus on our own area of interest; DOS from simple, pluripotent starting materials.
Spandl
Richard J
RJ
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
Díaz-Gavilán
Mónica
M
O'Connell
Kieron M G
KM
Thomas
Gemma L
GL
Spring
David R
DR
D002625:Chemistry, Organic / Q000379:methods* / Q000639:trends; D002626:Chemistry, Pharmaceutical / Q000379:methods* / Q000639:trends; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*
D004364:Pharmaceutical Preparations