Preeclampsia risk and angiotensinogen polymorphisms M235T and AGT -217 in African American and Caucasian women.
BACKGROUND
Genetic variants of the angiotensinogen gene have been linked to both hypertension and preeclampsia. The M235T polymorphism is more common in hypertension and preeclampsia in some populations. A polymorphism in the angiotensinogen basal promoter region of AGT -217 is more common in African Americans with hypertension. The authors investigated the frequency of M235T and AGT -217 in Caucasian and African American women with and without preeclampsia.


METHODS
The study was a nested case-control study of primiparous women with singleton pregnancies. Genomic DNA from preeclamptic and control subjects underwent polymerase chain reaction amplification and restriction digestion.


RESULTS
The M235T and AGT -217 polymorphisms were both more common in African American women; however, the variants were not more common in preeclampsia.


CONCLUSIONS
The frequency of angiotensinogen polymorphisms M235T and AGT -217 is different by race; however, these polymorphisms are not associated with an increased risk of preeclampsia.
Magee-Women's Research Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. jenkinsld@upmc.edu
Laura D
LD
Jenkins
Robert W
RW
Powers
Mary
M
Cooper
Marcia J
MJ
Gallaher
Nina
N
Markovic
Robert
R
Ferrell
Roberta B
RB
Ness
James M
JM
Roberts
D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000235:genetics*; D000808:Angiotensinogen / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011225:Pre-Eclampsia / Q000209:etiology / Q000235:genetics*; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D044465:White People / Q000235:genetics*; D055815:Young Adult
D000808:Angiotensinogen