Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy.
A variety of natural products modulate critical biological processes in the microorganisms that produce them. Thus, inhibition of the corresponding natural product biosynthesis pathways represents a promising avenue to develop novel antibiotics. In this tutorial review, we describe several recent examples of designed small molecule inhibitors of microbial natural product biosynthesis and their use in evaluating this emerging antibiotic strategy.
Tri-Institutional Training Program in Chemical Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 422, New York, NY 10065, USA.
Justin S
JS
Cisar
Derek S
DS
Tan
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology*; D001688:Biological Products / Q000096:biosynthesis / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D008954:Models, Biological; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
D000900:Anti-Bacterial Agents; D001688:Biological Products; D004791:Enzyme Inhibitors