Mechanical inhibition of angiogenesis at the saphenofemoral junction in the surgical treatment of varicose veins: early results of a blinded randomized controlled trial.
BACKGROUND
Saphenofemoral junction (SFJ) ligation has been a major component of surgical intervention for varicose veins; however, recurrence occurs in as many as 40%. Neovascularization with reconnection of the venous channels at the transected SFJ has been identified as the major cause of this recurrence. This randomized controlled study sought to evaluate mechanical suppression of neovascularization at the SFJ, with the use of a synthetic patch, to prevent recurrence after ligation surgery.


RESULTS
A total of 389 limbs (from 292 patients) were randomized into either control (SFJ ligation surgery) or patch (SFJ ligation with polytetrafluoroethylene patch of the transected SFJ) groups. All patients underwent clinical assessment, duplex imaging, and air plethysmography studies preoperatively and at 1, 6, 12, and 36 months postoperatively. The patch consistently halved the recurrence rate to 3 years postoperatively in all clinical subgroups. In those patched SFJs that still developed recurrence, evidence of neovascularization circumventing the polytetrafluoroethylene patch was observed by both ultrasound and histology.


CONCLUSIONS
This study demonstrates that use of a polytetrafluoroethylene patch is an effective mechanical suppressant of neovasculogenesis at the SFJ and can be safely used as a strategy to improve long-term outcome of varicose vein surgery.
Department of Surgery, Dunedin School of Medicine, University of Otago, PO Box 931, Dunedin, New Zealand. andre.vanrij@stonebow.otago.ac.nz
André M
AM
van Rij
Gregory T
GT
Jones
B Geraldine
BG
Hill
Mohammad
M
Amer
Ian A
IA
Thomson
Ross A
RA
Pettigrew
Stephen G K
SG
Packer
D004311:Double-Blind Method; D004869:Equipment Safety; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000098:blood supply; D008026:Ligation; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000503:physiopathology / Q000517:prevention & control* / Q000601:surgery; D011138:Polytetrafluoroethylene; D019736:Prostheses and Implants; D012501:Saphenous Vein / Q000503:physiopathology / Q000601:surgery*; D055502:Secondary Prevention; D013995:Time; D016896:Treatment Outcome; D014648:Varicose Veins / Q000503:physiopathology / Q000601:surgery*; D014656:Vascular Surgical Procedures; D014689:Venous Insufficiency / Q000503:physiopathology / Q000601:surgery
D011138:Polytetrafluoroethylene