Association between 16S-23S internal transcribed spacer sequence groups of Mycobacterium avium complex and pulmonary disease.
Organisms within the Mycobacterium avium complex (MAC) may have differential virulence. We compared 33 subjects with MAC pulmonary disease to 75 subjects with a single positive culture without disease. M. avium isolates were significantly more likely to be associated with MAC pulmonary disease (odds ratio = 5.14, 95% confidence interval = 1.25 to 22.73) than M. intracellulare.
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. stout002@mc.duke.edu
Jason E
JE
Stout
Gregory W
GW
Hopkins
Jay R
JR
McDonald
Anita
A
Quinn
Carol D
CD
Hamilton
L Barth
LB
Reller
Richard
R
Frothingham
D000368:Aged; D016022:Case-Control Studies; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009162:Mycobacterium avium / Q000235:genetics* / Q000472:pathogenicity*; D015269:Mycobacterium avium Complex / Q000235:genetics* / Q000472:pathogenicity*; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D014397:Tuberculosis, Pulmonary / Q000382:microbiology*; D014774:Virulence
D004269:DNA, Bacterial; D021903:DNA, Ribosomal Spacer