[Age specific disorders in the lymphatic system functions during exogenic intoxication and the ways of their correction].
In mice-experiments the age increase of intoxication hematologic criterium, malonic dialdehyde level in blood serum and progressive inhibition of interstitial humoral transport and tissue lymphatic drainage are shown. Exogenic intoxication enhances these disorders. The medical preparations mexidol, emoxipinum, cytochrom C, chophitol, succinic acid and selen-active, besides inhibiting the process of lipid peroxidation, all exert lymphostimulating effect but of different degree, which is not directly dependent on their antioxidant properties. The possibility to decrease the intensity of lipid peroxide oxidation and other components of intoxication syndrome using interstitial humoral transport and tissue lymphatic drainage stimulation combined with mexidol and chophitol is shown, but in old mice as compared to mature ones medicaments correction of intoxication signs is less effective.
Popova
S A
SA
Sviridkina
L P
LP
Toporova
S G
SG
D000375:Aging / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D004195:Disease Models, Animal; D015227:Lipid Peroxidation / Q000187:drug effects*; D008196:Lymph; D008208:Lymphatic System / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D051379:Mice; D011041:Poisoning / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology
D000975:Antioxidants