Stress-associated or functional hypothalamic amenorrhea in the adolescent.
Stress-associated amenorrhea in the adolescent is likely similar to the disorder found in young reproductive-aged adults and is termed hypothalamic amenorrhea. The key defect is an abnormality in the secretion of gonadotropin-releasing hormone. This review examines the current studies that characterize the disorder and the plausible factor(s) that may account for the disturbances in gonadotropin-releasing hormone, and identifies directions for future research in this group of disorders.
Liu
James H
JH
Department of Reproductive Biology, Case Western Reserve School of Medicine, University Hospitals Case Medical Center, 11100 Euclid Avenue, MAC 7105, Cleveland, OH 44106-5034, USA. James.Liu@case.edu
Bill
Arthur H
AH
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology* / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000502:physiology* / Q000503:physiopathology; D013315:Stress, Psychological / Q000150:complications*; D013961:Thyroid Gland / Q000502:physiology* / Q000503:physiopathology