Three-component coupling using arynes and aminosilanes for ortho-selective double functionalization of aromatic skeletons.
Arynes were found to couple with aminosilanes and carbonyl compounds in the presence of benzoic acid to provide 2-aminobenzhydrols. Sulfonylimines could also be applied to the reaction, enabling amino and aminomethyl moieties to be incorporated into contiguous positions of aromatic skeletons. Only a small amount of the three-component coupling product was obtained in the absence of benzoic acid, which confirms its vital role in the present reaction.
Morishita
Takami
T
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima, Japan.
Fukushima
Hiroyuki
H
Yoshida
Hiroto
H
Ohshita
Joji
J
Kunai
Atsutaka
A