Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: effect of alkyl chain length.
A series of fatty acid monoester derivatives of (-)-epigallocatechin-3-O-gallate (EGCG) were prepared by one-pot lipase-catalyzed transesterification. The introduction of long alkyl chains enhanced anti-influenza A/PR8/34 (H1N1) virus activity 24-fold relative to native EGCG.
The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.
Shuichi
S
Mori
Shinya
S
Miyake
Takayoshi
T
Kobe
Takaaki
T
Nakaya
Stephen D
SD
Fuller
Nobuo
N
Kato
Kunihiro
K
Kaihatsu
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002384:Catalysis; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003902:Detergents / Q000737:chemistry; D004285:Dogs; D015195:Drug Design; D005227:Fatty Acids / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry; D053118:Influenza A Virus, H1N1 Subtype / Q000378:metabolism*; D008956:Models, Chemical; D010636:Phenols / Q000737:chemistry; D059808:Polyphenols; D012995:Solubility; D014867:Water / Q000737:chemistry
D000998:Antiviral Agents; D003902:Detergents; D005227:Fatty Acids; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D014867:Water; D002392:Catechin; C045651:epigallocatechin gallate