Cytomegalovirus retinitis and immune recovery uveitis in AIDS patients treated with highly active antiretroviral therapy in Taiwanese.
OBJECTIVE
To determine the characteristics of cytomegalovirus (CMV) retinitis and immune recovery uveitis (IRU) in the era of highly active antiretroviral therapy (HAART).


METHODS
We reviewed data from 47 of 79 consecutive patients with acquired immunodeficiency syndrome (AIDS) and CMV retinitis.


RESULTS
The incidence of CMV retinitis in AIDS patients has markedly decreased over the recent 10 years. The characteristics of CMV retinitis have changed. Development of IRU occurred in 24.4%.


CONCLUSIONS
Symptomatic IRU develops in a significant number of patients with inactive CMV retinitis following successful HAART. Eyes with IRU respond favorably to antiinflammatory therapy without reactivation of retinitis.
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Yu-Chi
YC
Lin
Chang-Hao
CH
Yang
Chang-Ping
CP
Lin
Chung-May
CM
Yang
Muh-Shy
MS
Chen
Mao-Yuan
MY
Chen
Wang-Huei
WH
Sheng
Chien-Ching
CC
Hung
Shan-Chwen
SC
Chang
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy / Q000208:ethnology / Q000503:physiopathology*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D017726:Cytomegalovirus Retinitis / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007107:Immune System / Q000503:physiopathology*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function; D012189:Retrospective Studies; D013624:Taiwan / Q000453:epidemiology; D014605:Uveitis / Q000209:etiology* / Q000276:immunology