Facilitated transport of penicillin G by bulk liquid membrane with TBP as carrier.
The facilitated transport of penicillin G from aqueous solutions to the stripping phase through bulk liquid membrane (BLM) containing TBP in 3% iso-octanol and n-butyl acetate was studied. Na(2)CO(3) solution was used as the stripping phase. Experiments were performed as a function of stirring rate, TBP concentration and type of diluent in the liquid membrane phase, pH, and initial penicillin G concentration in the feed phase, Na(2)CO(3) concentration in the stripping phase, etc. The results showed that the BLM process could carry out the simultaneous separation and concentration of penicillin G from dilute aqueous solutions, and arise "up-hill" effect due to the characteristic of non-equilibrium mass transfer. The diffusion of penicillin G complex in the liquid membrane phase played an important role in BLM process. The mass transfer mechanism of BLM for this system was also discussed.
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, People's Republic of China.
Zhongqi
Z
Ren
Yuanyuan
Y
Lv
Weidong
W
Zhang
D000085:Acetates / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008567:Membranes, Artificial; D010755:Organophosphates / Q000737:chemistry*; D010400:Penicillin G / Q000737:chemistry* / Q000302:isolation & purification*; D013997:Time Factors
D000085:Acetates; D002254:Carbonates; D008567:Membranes, Artificial; D010755:Organophosphates; C005686:sodium carbonate; C006848:butyl acetate; C009524:tributyl phosphate; D010400:Penicillin G