[Evaluation of supplemental administration of Eviprostat in patients with benign prostatic hyperplasia with persistent symptoms following treatment with alpha1-adrenoceptor blocker].
We examined the effectiveness of supplemental administration of Eviprostat in patients with benign prostatic hyperplasia (BPH) whose lower urinary tract symptoms (LUTS) caused by BPH were not adequately relieved by an alpha1-adrenoceptor blocker. Twenty-nine patients with insufficient improvement in the International Prostate Symptom Score (IPSS) and quality of life (QOL) score after administration of 50 mg naftopidil for 4 weeks or more received 6 tablets of Eviprostat in addition to naftopidil for another 2 weeks or more. With supplemental administration of Eviprostat, significant improvement was observed in the symptoms of incomplete emptying, daytime frequency, intermittency, weak stream, total IPSS, sum of the IPSS subscores for voiding symptoms (intermittency, weak stream and straining), sum of the IPSS subscores for storage symptoms (daytime frequency, urgency and nocturia), and QOL score. Supplemental administration of Eviprostat is therefore effective for the improvement of LUTS and QOL in BPH patients resistant to an alpha1-adrenoceptor blocker.
Department of Urology, JR Tokyo General Hospital.
Takehito
T
Naruoka
Yasuyuki
Y
Suzuki
Akira
A
Furuta
Katsuhisa
K
Endo
Shingo
S
Sugaya
Shin
S
Egawa
D058668:Adrenergic alpha-1 Receptor Antagonists; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004338:Drug Combinations; D004979:Ethamsylate / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000037:antagonists & inhibitors; D010879:Piperazines / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000008:administration & dosage*; D011470:Prostatic Hyperplasia / Q000188:drug therapy* / Q000503:physiopathology; D011788:Quality of Life
D058668:Adrenergic alpha-1 Receptor Antagonists; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D009281:Naphthalenes; D010879:Piperazines; D010936:Plant Extracts; D004979:Ethamsylate; C010152:eviprostat; C064357:naftopidil