Novel combination of anionic and cationic polymethacrylate polymers for sustained release tablet preparation.
The objectives of this study were to prepare and evaluate a novel sustained release tablet formulation using a binary mixture of polymethacrylate polymers: Eudragit E-100 (EE) and Eudragit L-100 (EL) in their salt forms. Tablets prepared using EE-citrate and EL-Na showed the highest degree of swelling among other combinations of EE and EL. The drug release rates were independent of the pH of the dissolution medium as the release profiles exhibited a continuous release pattern with no burst effect when changing the pH of the medium. These results, along with other test results, indicated the presence of an ionic interaction between both polymers when combined in the salt forms.
Department of Pharmaceutical Technology, Jordan University of Science and Technology, Irbid, Jordan. obeidatw @just.edu.jo
Wasfy M
WM
Obeidat
Ala'a H
AH
Abu Znait
Al-Sayed A
AS
Sallam
D000082:Acetaminophen / Q000737:chemistry*; D000179:Acrylates / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D000179:Acrylates; D003692:Delayed-Action Preparations; C477020:Eudragit E100; D005079:Excipients; D011108:Polymers; D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer; D000082:Acetaminophen; C518398:Eudragit E PO