Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis.
OBJECTIVE
To determine the contribution of triggering receptor expressed on myeloid cells (TREM)-1 in acute pancreatitis (AP).


METHODS
Prospective study.


METHODS
General intensive care unit at Kobe University Hospital.


METHODS
Forty-eight patients with AP and seven patients as control.


METHODS
None.


RESULTS
We measured serum concentrations of soluble TREM-1 (sTREM-1) at the time of admission by enzyme-linked immunoadsorbent assay. Serum sTREM-1 levels increased significantly in AP (63 +/- 11 pg/mL) and correlated with Ranson score (R = .628, p < .001) and Acute Physiology and Chronic Health Evaluation II score (R = .504, p < .001). Serum TREM-1 levels were higher in patients with early organ dysfunction (which occurred within 7 days after onset) than those without early organ dysfunction (101 +/- 19 vs. 25 +/- 4 pg/mL, p < .001). Incidences of early organ dysfunction in patients whose serum sTREM-1 levels were < or = 40 and > 40 pg/mL were 17% and 83%, respectively (p < .001). The usefulness of serum sTREM-1 in detecting early organ dysfunction was superior to that of C-reactive protein, interleukin-6, interleukin-8, Ranson score, and Acute Physiology and Chronic Health Evaluation II score. Serum sTREM-1 levels decreased with resolution of early organ dysfunction.


CONCLUSIONS
Serum sTREM-1 levels were significantly increased and correlated with disease severity and early organ dysfunction in patients with AP. Serum sTREM-1 level may be a useful marker for early organ dysfunction in AP.
Yasuda
Takeo
T
Department of Surgery, Kinki University School of Medicine, Osaka-sayama, Japan. yasudatk@surg.med.kindai.ac.jp
Takeyama
Yoshifumi
Y
Ueda
Takashi
T
Shinzeki
Makoto
M
Sawa
Hidehiro
H
Takahiro
Nakajima
N
Kamei
Keiko
K
Ku
Yonson
Y
Kuroda
Yoshikazu
Y
Ohyanagi
Harumasa
H
D018806:APACHE; D015415:Biomarkers; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D022423:Myeloid Cells / Q000378:metabolism*; D010195:Pancreatitis / Q000097:blood* / Q000145:classification; D012372:ROC Curve; D011971:Receptors, Immunologic / Q000097:blood*; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
D015415:Biomarkers; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1