[Oxidative stress in porphyria and carriers].
We sought to establish a causal relationship between oxidative stress and porphyria in patients and carriers. We reported changes in urinary porphyrin concentrations related to 8-hydroxy-2'-deoxyguanosine.


METHODS
We measured urinary 8-hydroxy-2'-deoxyguanosine concentration in porphyria patients and carriers with multifactorial inheritance as a possible marker of attack. The porphyria types included 10 patients with porphyria cutanea tarda, 5 with variegate porphyria, 8 with hereditary coproporphyria, 7 with congenital erythropoietic porphyria, 5 with erythropoietic protoporphyria, 5 with acute intermittent porphyria, 7 erythropoietic protoporphyria carriers, and 7 acute intermittent porphyria carriers.


RESULTS
Urinary porphyrin concentrations in these patients were significantly higher than those in healthy subjects (p<0.001). Urinary 8-hydroxy-2'-deoxyguanosine concentrations were significantly high in dermatopathy porphyria types namely porphyria cutanea tarda (p<0.001), variegate porphyria (p<0.05), hereditary coproporphyria (p<0.05), congenital erythropoietic phyria (p<0.05), and erythropoietic protoporphyria (p<0.001).


CONCLUSIONS
These results reveal that urinary 8-hydroxy-2'-deoxyguanosine concentration in cutis porphyria types is a good predictor of attack and abatement.
Aminaka
Masahito
M
Department of Preventive Medicine, St. Marianna University School of Medicine, Kawasaki, Japan. m2ami@marianna-u.ac.jp
Kondo
Masao
M
Takata
Ayako
A
Yamauchi
Hiroshi
H
Ikeda
Maki
M
Yoshida
Katsumi
K
D000080242:8-Hydroxy-2'-Deoxyguanosine; D015415:Biomarkers / Q000652:urine; D002353:Carrier State / Q000145:classification / Q000175:diagnosis*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D017119:Porphyria Cutanea Tarda / Q000175:diagnosis; D046350:Porphyria, Variegate / Q000175:diagnosis; D011164:Porphyrias / Q000145:classification / Q000175:diagnosis* / Q000209:etiology*
D015415:Biomarkers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine