Chemical constituents of Aristolochia constricta: antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid.
Twenty constituents were isolated from the n-hexane and chloroform extracts of Aristolochia constricta, a plant whose aerial parts have been used empirically in folk medicine for various purposes. The inhibitory effects of these constituents on smooth muscle contraction in isolated guinea-pig ileum were studied in order to observe their antispasmodic effects. 3,4-Dibenzyldihydrofuran-type lignans [(-)-cubebin, (-)-hinokinin, and (-)-pluviatolide] and a kaurene-type diterpene [(-)-kaur-16-en-19-oic acid] were isolated as active principals. They inhibited electrically induced and acetylcholine-induced contraction in the isolated guinea-pig ileum. In addition, 9- O-[(-)-kaur-15-en-17-oxyl]cubebin was isolated as a new diterpeno-lignan hybrid, although this constituent did not exhibit antispasmodic activity.
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan.
Gang
G
Zhang
Satoko
S
Shimokawa
Matsuri
M
Mochizuki
Takuya
T
Kumamoto
Waka
W
Nakanishi
Toshiko
T
Watanabe
Tsutomu
T
Ishikawa
Kenjiro
K
Matsumoto
Kimihito
K
Tashima
Syunji
S
Horie
Yoshihiro
Y
Higuchi
Oswaldo Pesantes
OP
Dominguez
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D030022:Aristolochia / Q000737:chemistry*; D052117:Benzodioxoles; D004149:Dioxoles / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004484:Ecuador; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008519:Medicine, Traditional; D010276:Parasympatholytics / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism
C531481:9-O-(kaur-15-en-17-oxyl)cubebin; D052117:Benzodioxoles; D004149:Dioxoles; D004224:Diterpenes; D017705:Lignans; D010276:Parasympatholytics; C475934:hinokinin; C433065:cubebin; D015107:4-Butyrolactone