Systemic administration of doxycycline versus metronidazole plus amoxicillin in the treatment of localized aggressive periodontitis: a clinical and microbiologic study.
OBJECTIVE
The use of antibiotics as an adjunctive therapy in the management of periodontal diseases has always been of interest for dental practitioners. Although studies have demonstrated the importance of different antibiotics as adjunct in the treatment of periodontitis, few studies have reported comparative results of antibiotics in localized aggressive periodontitis (LAP). The aim of the present study was to evaluate the comparative effects of systemic tetracycline derivative doxycycline versus a combination of metronidazole and amoxicillin in the elimination/suppression of Actinobacillus actinomycetemcomitans and their clinical effects during 90 days of follow-up in patients with LAP.


METHODS
Thirty patients with untreated LAP participated in the study. Patients were randomly divided into 2 groups and given doxycycline or metronidazole plus amoxicillin, and periodontal clinical parameters were achieved at baseline and 10, 30, 60, and 90 days after microbiologic sampling. Patients were also given mechanical debridement after measurement at baseline.


RESULTS
Both groups of patients demonstrated improvement in clinical parameters, and microbiologic samples did not show any A actinomycetemcomitans at days 30, 60, and 90.


CONCLUSIONS
Systemic use of doxycycline or metronidazole plus amoxicillin as an adjunct to conventional therapy may be used for the treatment of patients with LAP.
Department of Periodontology, Hacettepe University, Ankara, Turkey.
Hakan
H
Akincibay
Sibel O
SO
Orsal
Dilek
D
Sengün
Tolga F
TF
Tözüm
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects*; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002214:Capsules; D003773:Dental Plaque / Q000382:microbiology; D003774:Dental Plaque Index; D012534:Dental Scaling; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D017622:Periodontal Attachment Loss / Q000188:drug therapy / Q000382:microbiology; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000188:drug therapy / Q000382:microbiology; D010518:Periodontitis / Q000188:drug therapy* / Q000382:microbiology; D016745:Root Planing
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002214:Capsules; D004338:Drug Combinations; D008795:Metronidazole; D000658:Amoxicillin; D004318:Doxycycline