[Activity of cytokines in chronic HCV-infected patients].
Nonspecific immunology response and apoptotic pathways play the important role in development of chronic hepatitis C. HCV stimulates synthesis of many cytokines, mainly proinflammatory. In these processes, the activation of Thl and Th2 lymphocytes has a particular significance. Stronger activation of Th1 lymphocytes has an influence on dysregulation of cytokines' synthesis, affecting also the protraction of HCV infection. Cognition of HCV influence on the regulation of nonspecific immunology response and apoptotic pathways could bring nearer the comprehension of chronic hepatitis C development and indicate new treatment's directions.
Lapiński
Tadeusz Wojciech
TW
Wojewódzki Szpital Specjalistyczny im. K Dłuskiego w Białymstoku. twlapinski@wp.pl
Dabrowska
Magdalena Monika
MM
D015703:Antigens, CD / Q000378:metabolism*; D016174:Hepacivirus / Q000276:immunology*; D019698:Hepatitis C, Chronic / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D007694:Killer Cells, Natural / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism*; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015703:Antigens, CD; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D015847:Interleukin-4