[Technology of vitamins containing double layer suppositories].
At present ascorbic acid and cyanocobalamin are widely used in medical practice. Often they are administered simultaneously; chemically they are incompatible, as ascorbic acid (redox compound) inactivates cyanocobalamin. The combination of ascorbic acid and cyanocobalamin is the problem of pharmacy. To solve the problem double-layer suppositories containing two incompatible vitamins: ascorbic acid and cyanocobalamin were developed. Pharmaceutical bioavailability of ascorbic acid and cyanocobalamin has been studied using in-vitro methods to develop optimal base for suppositories. As a result of investigations optimal composition and technology of the double-layer suppositories containing ascorbic acid and cyanocobalamin which met requirements has been developed. Sequential release of active compounds and as a result - sequential pharmacologic action is achieved.
Bakuridze
A Dzh
AD
Maglakelidze
G M
GM
Kurdiani
N G
NG
Tsagareishvili
N T
NT
Berashvili
D T
DT
D001205:Ascorbic Acid / Q000032:analysis; D020811:Biomedical Technology / Q000379:methods*; D006801:Humans; D013488:Suppositories / Q000737:chemistry*; D014805:Vitamin B 12 / Q000032:analysis; D014815:Vitamins / Q000032:analysis*
D013488:Suppositories; D014815:Vitamins; D014805:Vitamin B 12; D001205:Ascorbic Acid