Immunocytochemistry of neuron specific enolase (NSE) in the rat brain after single and repeated epileptic seizures.
The aim of this study was to investigate neuron-specific enolase (NSE) immunoreactivity of the different brain regions after pentylenetetrazol (PTZ)- induced epileptic seizures in rats. Light microscopic examinations provided evidences for changes of neuronal activity after single and repeated seizures. The number of NSE (+) cells was well correlated with Nissl staining. The results suggest that NSE immunoreactivity may be a valuable marker for determination of the number of metabolically active neurons in different brain regions after single and repeated experimental seizures.
Yardimoğlu
Melda
M
Department of Histology & Embryology, Kocaeli University, School of Medicine, Kocaeli, Turkey. docdrmelda@yahoo.com
Ilbay
Gul
G
Dalcik
Cannur
C
Dalcik
Hakki
H
Sahin
Deniz
D
Ates
Nurbay
N
D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology / Q000201:enzymology* / Q000503:physiopathology; D001931:Brain Mapping; D003292:Convulsants / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000502:physiology; D004827:Epilepsy / Q000139:chemically induced / Q000201:enzymology* / Q000503:physiopathology; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000201:enzymology; D010433:Pentylenetetrazole / Q000494:pharmacology; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D011237:Predictive Value of Tests; D051381:Rats; D017208:Rats, Wistar
D015415:Biomarkers; D003292:Convulsants; D010751:Phosphopyruvate Hydratase; D010433:Pentylenetetrazole