Solid-phase synthesis of heterocyclic nucleoside analogues: substituted uracils tethered to isoxazoles, isoxazolines, and triazoles from a selenopolystyrene resin.
A heterocyclic nucleoside analogue library of uracils N1 tethered to isoxazoles, isoxazolines, and triazoles and uracil N3 tethered to isoxazolines and isoxazoles was constructed by solid-phase organic synthesis. This strategy opens the way for the generation of small libraries of heterocyclic nucleoside analogues for biological screening.
Cao
Jian
J
Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou 310028, P. R. China.
Huang
Xian
X
D002851:Chromatography, High Pressure Liquid; D003500:Cyclization; D007555:Isoxazoles / Q000737:chemistry*; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry*; D012117:Resins, Synthetic / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*; D014498:Uracil / Q000737:chemistry*
D007555:Isoxazoles; D009705:Nucleosides; D011137:Polystyrenes; D012117:Resins, Synthetic; D014230:Triazoles; D014498:Uracil