Fetal middle cerebral artery Doppler velocimetry in cases of rhesus alloimmunization.
OBJECTIVE
To assess fetal middle cerebral artery (MCA) peak systolic velocity (PSV) in cases of rhesus alloimmunization and to establish whether MCA-PSV is valid for the prediction of fetal anemia.


METHODS
The study population included 157 pregnant women diagnosed with rhesus alloimmunization. MCA-PSV measurements were obtained within 3 days of blood sampling for estimation of hemoglobin concentration either at delivery or cordocentesis by the same operator and by means of the same ultrasound machine using techniques described previously. To evaluate the measurements of the MCA-PSV as the multiples of median (MoM) for gestation we used original nomograms for various gestational ages derived from a group of 273 normal fetuses between 22 and 40 weeks of gestation, not at risk for anemia. Receiver-operator characteristic (ROC) curves were employed to evaluate the relation of the sensitivity (the true positive rate) and the false positive rate (100% specificity) of different threshold values of the MCA-PSV.


RESULTS
The sensitivity of the MCA-PSV was 94.4% in the case of the subgroup of fetuses with severe anemia. The sensitivity of the MCA-PSV test decreased in less anemic fetuses and was 77.3% in the subgroup with moderate anemia and 32% in the subgroup with mild anemia. According to ROC curves, we selected the optimal MCA-PSV threshold values of 1.15, 1.44, and 1.53 MoM for the prediction of mild, moderate, and severe anemia, respectively.


CONCLUSIONS
MCA-PSV is a significant Doppler index valid for the prediction of moderate and severe fetal anemia.
Maciuleviciene
Regina
R
Department of Obstetrics and Gynecology, Hospital of Kaunas University of Medicine, Kaunas, Lithuania. regina4gau@yahoo.com
Gaurilcikas
Adrius
A
Simanaviciute
Daiva
D
Nadisauskiene
Ruta Jolanta
RJ
Gintautas
Vladas
V
Vaitkiene
Daiva
D
Baliutaviciene
Dalia Kotryna
DK
D000751:Anemia, Neonatal / Q000000981:diagnostic imaging*; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D017078:Laser-Doppler Flowmetry; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging*; D011247:Pregnancy; D011446:Prospective Studies; D012372:ROC Curve; D012203:Rh Isoimmunization / Q000000981:diagnostic imaging*; D016216:Ultrasonography, Prenatal