Ovarian hyperstimulation after a short course of an oral contraceptive in a patient with premature ovarian failure.
OBJECTIVE
To report a patient with premature ovarian failure who, after discontinuing a short course of therapy with an oral contraceptive, demonstrated clinical and biochemical evidence of ovarian hyperstimulation.


METHODS
Case report.


METHODS
Reproductive Center at a university hospital.


METHODS
31-year-old woman with premature ovarian failure.


METHODS
Triggered ovulation using recombinant human chorionic gonadotropin (hCG).


METHODS
Follicle sizes documented by transvaginal ultrasound and corresponding serum estradiol levels.


RESULTS
Hyperstimulated ovaries, documented by pelvic ultrasound, demonstrated lead follicles of 16, 22, 27, and 46 mm in average diameters. The serum estradiol level was 979 pg/mL with a serum progesterone of 0.87 ng/mL. Five days after triggered ovulation with recombinant hCG, serum progesterone levels rose to 13.8 ng/mL.


CONCLUSIONS
Ovarian hyperstimulation may occur after brief gonadotropin suppression in women with premature ovarian failure.
Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology and Infertility, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Pavna Kartha
PK
Brahma
Caleb B
CB
Kallen
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D004958:Estradiol / Q000097:blood; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D010053:Ovary / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D010062:Ovulation Induction; D016649:Primary Ovarian Insufficiency / Q000188:drug therapy*; D011374:Progesterone / Q000097:blood; D011994:Recombinant Proteins / Q000627:therapeutic use; D014463:Ultrasonography
D006063:Chorionic Gonadotropin; D003278:Contraceptives, Oral, Hormonal; D043373:Follicle Stimulating Hormone, Human; D011994:Recombinant Proteins; D011374:Progesterone; D004958:Estradiol