Variability in thyroid-stimulating hormone suppression by human chorionic [corrected] gonadotropin during early pregnancy.
OBJECTIVE
The objective of the study was to further explore relationships between human chorionic gonadotropin (hCG), TSH, and free T4 in pregnant women at 11 through 18 wk gestation.


METHODS
The design of the study was to analyze hCG in comparison with TSH and free T4, in paired first- and second-trimester sera from 9562 women in the First and Second Trimester Evaluation of Risk for Fetal Aneuploidy trial study.


RESULTS
hCG is strongly correlated with body mass index, smoking, and gravidity. Correlations with selected maternal covariates also exist for TSH and free T4. As hCG deciles increase, body mass index and percent of women who smoke both decrease, whereas the percent of primigravid women increases (P < 0.0001). hCG/TSH correlations are weak in both trimesters (r2 = 0.03 and r2 = 0.02). TSH concentrations at the 25th and fifth centiles become sharply lower at higher hCG levels, whereas 50th centile and above TSH concentrations are only slightly lower. hCG/free T4 correlations are weak in both trimesters (r2 = 0.06 and r2 = 0.003). At 11-13 wk gestation, free T4 concentrations rise uniformly at all centiles, as hCG increases (test for trend, P < 0.0001), but not at 15-18 wk gestation. Multivariate analyses with TSH and free T4 as dependent variables and selected maternal covariates and hCG as independent variables do not alter these observations.


CONCLUSIONS
In early pregnancy, a woman's centile TSH level appears to determine susceptibility to the TSH being suppressed at any given hCG level, suggesting that hCG itself may be the primary analyte responsible for stimulating the thyroid gland. hCG affects lower centile TSH values disproportionately.
The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA. jhaddow@ipmms.org
James E
JE
Haddow
Monica R
MR
McClain
Geralyn
G
Lambert-Messerlian
Glenn E
GE
Palomaki
Jacob A
JA
Canick
Jane
J
Cleary-Goldman
Fergal D
FD
Malone
T Flint
TF
Porter
David A
DA
Nyberg
Peter
P
Bernstein
Mary E
ME
D'Alton
D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood* / Q000378:metabolism; D011262:Pregnancy Trimester, Second / Q000097:blood* / Q000378:metabolism; D013972:Thyrotropin / Q000037:antagonists & inhibitors* / Q000097:blood / Q000378:metabolism; D013974:Thyroxine / Q000097:blood
D006063:Chorionic Gonadotropin; D013972:Thyrotropin; D013974:Thyroxine