Novel multicomponent one-pot synthesis of tetrahydro-1H-1,5-benzodiazepine-2-carboxamide derivatives.
A new approach to the design of multicomponent reactions is introduced. As a result, the novel one-pot synthesis of 2,3,4,5-tetrahydro-1 H-1,5-benzodiazepine-2-carboxamide derivatives using an aromatic diamine, a linear or cyclic ketone, an isocyanide, and water in the presence of a catalytic amount of p-toluenesulfonic acid at ambient temperature in high yields is described.
Shaabani
Ahmad
A
Department of Chemistry, Shahid Beheshti University, P.O. Box 19396-4716, Tehran, Iran. a-shaabani@cc.sbu.ac.ir
Maleki
Ali
A
Mofakham
Hamid
H
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D001552:Benzazepines / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure
D000577:Amides; D001552:Benzazepines; D006859:Hydrogen