PIP2 is a necessary cofactor for ion channel function: how and why?
Phosphatidylinositol 4,5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion transporters require PIP2 to function and can be turned off by signaling pathways that deplete PIP2. This review discusses the dependence of ion channels on phosphoinositides and considers possible mechanisms by which PIP2 and analogues regulate ion channel activity.
Suh
Byung-Chang
BC
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98195, USA. bcs@u.washington.edu
Hille
Bertil
B
D001665:Binding Sites; D015640:Ion Channel Gating / Q000502:physiology*; D007473:Ion Channels / Q000737:chemistry* / Q000378:metabolism*; D008954:Models, Biological; D008956:Models, Chemical; D008958:Models, Molecular; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding; D011487:Protein Conformation
D007473:Ion Channels; D019269:Phosphatidylinositol 4,5-Diphosphate