Design and characterization of an adhesive matrix based on a poly(ethyl acrylate, methyl methacrylate).
The main issue in the development of transdermal patches made of poly(ethyl acrylate, methyl methacrylate) (Eudragit NE 40D, PMM) is the shrinkage phenomenon during the spreading of the latex onto the release liner. To solve this problem, the latex is usually freeze-dried and then re-dissolved in an organic solvent (method 1). To simplify the production process, we prepared an adhesive matrix by adding to the commercial PMM latex a plasticizer and an additive (anti-shrinkage agent) that avoids the shrinkage of the water dispersion spread onto the release liner (method 2). In some cases the active ingredient itself, such as potassium diclofenac (DK) and nicotine (NT), works as anti-shrinkage agent. In this work, the effects of the preparation method, types and concentrations of the plasticizer (triacetin and tributyl citrate) on the adhesive properties of the transdermal patches were investigated. The adhesive properties of the prepared patch were determined by texture analysis, peel adhesion test and shear adhesion. The PMM/plasticizer interactions were evaluated by ATR-FTIR spectroscopy. Furthermore, the in vitro skin permeation profiles of DK and NT released from the patch were determined by Franz cell method. Generally speaking, the variables that mainly modify the adhesive properties are the concentration and type of the plasticizer. The skin permeation profiles of DK and NT from the patch prepared by method 2 overlapped with those obtained with the commercial products. The results underline that the PMM latex can be used conveniently in the development of transdermal patches.
Cilurzo
Francesco
F
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Università degli Studi di Milano, Viale Abruzzi, 42, 20133, Milan, Italy. francesco.cilurzo@unimi.it
Minghetti
Paola
P
Pagani
Stefania
S
Casiraghi
Antonella
A
Montanari
Luisa
L
D000180:Acrylic Resins / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D000268:Adhesiveness; D000269:Adhesives / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D000279:Administration, Cutaneous; D006801:Humans; D066298:In Vitro Techniques; D019904:Polymethyl Methacrylate / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology
D000180:Acrylic Resins; D000269:Adhesives; C478961:poly(ethylacrylate); D019904:Polymethyl Methacrylate