Tyrosine kinase signalling in embryonic stem cells.
Pluripotent ES (embryonic stem) cells can be expanded in culture and induced to differentiate into a wide range of cell types. Self-renewal of ES cells involves proliferation with concomitant suppression of differentiation. Some critical and conserved pathways regulating self-renewal in both human and mouse ES cells have been identified, but there is also evidence suggesting significant species differences. Cytoplasmic and receptor tyrosine kinases play important roles in proliferation, survival, self-renewal and differentiation in stem, progenitor and adult cells. The present review focuses on the role of tyrosine kinase signalling for maintenance of the undifferentiated state, proliferation, survival and early differentiation of ES cells.
Annerén
Cecilia
C
Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, 75123 Uppsala, Sweden. cecilia.anneren@imbim.uu.se
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D053595:Embryonic Stem Cells / Q000166:cytology / Q000201:enzymology*; D006801:Humans; D053605:Leukemia Inhibitory Factor / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D053605:Leukemia Inhibitory Factor; D011505:Protein-Tyrosine Kinases