Genotype-adjusted familial correlation analysis using three generalized estimating equations.
We analyze familial correlation of a memory score from Caribbean Hispanic families that have multiple family members affected with Alzheimer's disease, adjusting for having at least one APOE-epsilon4 allele, as well as other confounders. To enhance the efficiency of correlation model, this paper proposes an alternative approach for three generalized estimating equations proposed by Yan and Fine (Statist. Med. 2004; 23:859-874). The efficiency of correlation model is evaluated through the asymptotic relative efficiency computation and simulations.
Lee
Hye-Seung
HS
Pediatrics Epidemiology Center, University of South Florida, 3650 Spectrum Blvd., Suite 100, Tampa, FL 33612, USA. leeh@epi.usf.edu
Paik
Myunghee Cho
MC
Lee
Joseph H
JH
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D003198:Computer Simulation; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic
D053327:Apolipoprotein E4