Combination dual responsive polypeptide vectors for enhanced gene delivery.
Variation in amino acid sequences on a disulfide-linked polypeptide backbone generates differing pK(a) vectors for DNA delivery, which release nucleic acids under reducing conditions and transfect cells with greater efficacy than non-reducible or non-variable pK(a) analogues.
Nasanit
Rujikan
R
School of Chemistry, University of Birmingham, UK. j.a.preece@bham.ac.uk
Iqbal
Parvez
P
Soliman
Mahmoud
M
Spencer
Neil
N
Allen
Stephanie
S
Davies
Martyn C
MC
Briggs
Simon S
SS
Seymour
Leonard W
LW
Preece
Jon A
JA
Alexander
Cameron
C
D004247:DNA / Q000737:chemistry / Q000648:ultrastructure; D004220:Disulfides / Q000737:chemistry; D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D018625:Microscopy, Atomic Force; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism
D004220:Disulfides; D010455:Peptides; D004247:DNA