The influence of Hofmeister series ions on hyaluronan swelling and viscosity.
The dissolution of hyaluronan in water leads to its degradation, and as a result its molecular weight decreases. The degradation of hyaluronan is mainly influenced by temperature, solution composition, and also its pH. This study describes the influence of Hofmeister series ions on hyaluronan behaviour and hyaluronan film swelling by solutions of these ions. It was found that Hofmeister ions show lyotropic effects influencing the entanglement of hyaluronan coils and their expansion from solid polymer films into swollen gel state. The hydrophobic and hydrophilic interactions in the structure of hyaluronan macromolecules are represented by the mutual diffusion coefficient D(c), the mean mutual diffusion coefficient D(s), the expansion work of coil swelling RA(delta,s), the activation enthalpy of diffusion connected with swelling H(D,s) and kinematic viscosity of hyaluronan-ions solutions nu.
Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlín, Nad Stránemi 4511, 76005 Zlín, Czech Republic. mracek@ft.utb.cz
Ales
A
Mrácek
Júlia
J
Varhaníková
Marián
M
Lehocký
Lenka
L
Grundelová
Alena
A
Pokopcová
Vladimír
V
Velebný
D001696:Biomechanical Phenomena; D004058:Diffusion; D006820:Hyaluronic Acid / Q000737:chemistry*; D007477:Ions / Q000737:chemistry / Q000494:pharmacology; D008956:Models, Chemical; D011312:Pressure; D012996:Solutions; D014783:Viscosity / Q000187:drug effects; D014867:Water
D007477:Ions; D012996:Solutions; D014867:Water; D006820:Hyaluronic Acid