Randomized clinical trial with two palliative radiotherapy regimens in painful bone metastases: 30 Gy in 10 fractions compared with 8 Gy in single fraction.
OBJECTIVE
The aim was to demonstrate similar pain relief with two schedules of radiotherapy for painful bone metastases.


METHODS
A total of 160 patients were assigned to receive a single 8-Gy fraction or 30 Gy in 10 fractions. Pain intensity was measured on an ordinal pain scale of 0-10. Partial response was defined as a pain reduction of two points or more and complete response as a pain score of zero at the treated area. Response follow-up was at 3, 12, 24 and 48 weeks.


RESULTS
The overall response was 75% in the 8-Gy arm and 86% in the 30-Gy arm. Complete response and partial response rates were 15% and 60% in the 8-Gy arm, 13% and 73% in the 30-Gy arm. Acute toxicity was of 18% in the 30-Gy arm and of 12% in the 8-Gy arm. These differences were not statistically significant. The re-treatment rate was 28% vs 2% in the 8-Gy and 30-Gy arms, respectively, these were statistically significant.


CONCLUSIONS
A single-fraction regimen of 8 Gy was as safe and effective as a multifraction regimen of 30 Gy for painful bone metastases in terms of pain relief.
Radiation Oncology Department, Hospital de l'Esperança, Barcelona, Spain. pforo@imas.imim.es
Palmira
P
Foro Arnalot
Agustí Valls
AV
Fontanals
Joan Carles
JC
Galcerán
Frances
F
Lynd
Xavier Sanz
XS
Latiesas
Nuria Rodríguez
NR
de Dios
Anna Reig
AR
Castillejo
Marti Lacruz
ML
Bassols
Joan Lozano
JL
Galán
Ismael Membrive
IM
Conejo
Manuel Algara
MA
López
D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010166:Palliative Care / Q000379:methods*; D011879:Radiotherapy Dosage; D018709:Statistics, Nonparametric; D016896:Treatment Outcome