[Relationship between mitochondrial DNA and myelodysplastic syndromes - review].
Mitochondria is the main place of biological oxidation and energy transform. Mitochondrial DNA encodes the complex of respiratory chain in mitochondria and its mutation can cause a series of human disease. Mitochondrial DNA mutation which observed in myelodysplastic syndrome (MDS) patients cause the MDS by the mechanism of iron metabolism disorder, gene instability and hemopoietic progenitor cell apoptosis. In this review the characteristics of mitochondrial DNA structure, the mitochondrial DNA mutation and the possible mechanism of mitochondrial DNA mutation in pathogenesis of MDS were summarized.
Zhang
Qian-Qiao
QQ
Department of Hematplogy, The Sixth People Hospital, Shanghai Jiaotong University, Shanghai 200233, China.
Li
Xiao
X
D000756:Anemia, Sideroblastic / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000235:genetics*; D017354:Point Mutation
D004272:DNA, Mitochondrial