Synthesis and biological activity of mustard derivatives of thymine.
The synthesis and biological activity of a novel DNA cross-linking antitumor agent is presented. The new alkylating agent significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line.
Laboratoire de Chimie des Substances Naturelles, Faculte des Sciences et Techniques Limoges, Universite de Limoges, France.
Amel
A
Hadj-Bouazza
Karine
K
Teste
Ludovic
L
Colombeau
Vincent
V
Chaleix
Rachida
R
Zerrouki
Michel
M
Kraemer
Odile
O
Sainte Catherine
D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D006801:Humans; D020778:Matrix Metalloproteinase 2; D061965:Matrix Metalloproteinase Inhibitors; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D009588:Nitrogen Mustard Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013941:Thymine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
D018906:Antineoplastic Agents, Alkylating; D061965:Matrix Metalloproteinase Inhibitors; D009588:Nitrogen Mustard Compounds; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D013941:Thymine