Insights in the antibacterial action of poly(methyloxazoline)s with a biocidal end group and varying satellite groups.
The antimicrobial activity of poly(2-methyl-1,3-oxazoline)s (PMOX) with the antimicrobial N,N-dimethyldodecylammonium (DDA) end group is greatly dependent on the nature of the group at the distal end of the polymer, the satellite group. Three comparable PMOX with a DDA end group and different satellite groups (methyl, decyl, hexadecyl) were investigated with respect to the reasons for the huge differences in their biocidal behavior. Static light scattering (SLS) and pulsed field gradient diffusion NMR measurements revealed that the samples show comparable aggregation conduct, thus, not being responsible for the varying biological activity. Experiments using different liposomal systems as models for bacterial cell membranes have been performed. It was found that differential interactions between the respective polymers and the phospholipid membranes constitute the reason for the varying effectiveness observed in antimicrobial susceptibility determinations.
Waschinski
Christian J
CJ
Freiburg Material Research Center, University of Freiburg, Stefan-Meier-Str 21, D-79104 Freiburg, Germany.
Barnert
Sabine
S
Theobald
Alice
A
Schubert
Rolf
R
Kleinschmidt
Felix
F
Hoffmann
Anke
A
Saalwächter
Kay
K
Tiller
Joerg C
JC
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001419:Bacteria / Q000648:ultrastructure; D002462:Cell Membrane / Q000187:drug effects; D008081:Liposomes; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D010080:Oxazoles / Q000737:chemistry* / Q000494:pharmacology*; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D008081:Liposomes; D010080:Oxazoles; D011108:Polymers