[Is it CNS vasculitis? Essential thrombocythaemia with a normal platelet count].
A 58-year old woman was admitted with transient ischaemic attacks. Cerebral MRI was compatible with vasculitis. Blood chemistry was normal, but after 9 months she developed thombocytosis above 600 x 10(9)/L. A bone marrow biopsy showed myeloproliferative changes. Further investigations revealed over-expression of the polycythaemia rubra vera-1 gene and she carried the Janus Kinase-2 mutation, V617F. This case emphasizes that a myeloproliferative disorder should be considered in patients with unexplained ischemic CNS manifestations, even if blood counts are normal.
Comstedt
Lisbeth Rosholm
LR
Bangs Boder 21, DK-5000 Odense C. lrosholm@hotmail.com
Junker
Peter
P
D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000175:diagnosis; D008875:Middle Aged; D010976:Platelet Count; D013922:Thrombocytosis / Q000175:diagnosis*; D020293:Vasculitis, Central Nervous System / Q000175:diagnosis*