Chronic alcohol consumption increases the severity of murine influenza virus infections.
Respiratory infections with both seasonal as well as potential pandemic Influenza viruses represent a significant burden on human health. Furthermore, viruses such as Influenza are increasingly recognized as important etiologic agents in community acquired pneumonia. Within the U.S. alone, approximately 12.9 million people are heavy drinkers and chronic abuse of alcohol is known to increase the risk and severity of community acquired pneumonia. Given the lack of knowledge regarding Influenza disease in this population, we determined the effects of chronic alcohol consumption on Influenza virus infection. Herein, we report that mice exposed to chronic ethanol have sharp increases in morbidity, mortality, and pulmonary virus titers relative to controls. These increases in influenza severity correspond with inhibited pulmonary influenza-specific CD8 T cell responses. Further, chronic ethanol consumption results in an enhanced pulmonary lesion severity, similar to that recently described for pandemic influenzas. Together, our results suggest that chronic alcohol consumption may increase the risk for severe influenza virus infections by altering the pulmonary inflammatory environment and CD8 T cell response.
Department of Pathology, University of Iowa, Iowa City, IA 52242, USA.
David K
DK
Meyerholz
Michelle
M
Edsen-Moore
Jodi
J
McGill
Ruth A
RA
Coleman
Robert T
RT
Cook
Kevin L
KL
Legge
D000428:Alcohol Drinking / Q000503:physiopathology*; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002465:Cell Movement / Q000276:immunology; D005260:Female; D053118:Influenza A Virus, H1N1 Subtype / Q000502:physiology*; D053121:Influenza A Virus, H2N2 Subtype / Q000502:physiology*; D007371:Interferon-gamma / Q000096:biosynthesis; D008171:Lung Diseases / Q000473:pathology; D051379:Mice; D009504:Neutrophils / Q000166:cytology / Q000276:immunology; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000473:pathology* / Q000821:virology; D015996:Survival Rate; D013997:Time Factors
D007371:Interferon-gamma