Solid-phase synthesis of heterocyclic nucleoside analogues: substituted uracils tethered to isoxazoles, isoxazolines, and triazoles from a selenopolystyrene resin.
A heterocyclic nucleoside analogue library of uracils N1 tethered to isoxazoles, isoxazolines, and triazoles and uracil N3 tethered to isoxazolines and isoxazoles was constructed by solid-phase organic synthesis. This strategy opens the way for the generation of small libraries of heterocyclic nucleoside analogues for biological screening.
Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou 310028, P. R. China.
Jian
J
Cao
Xian
X
Huang
D002851:Chromatography, High Pressure Liquid; D003500:Cyclization; D007555:Isoxazoles / Q000737:chemistry*; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry*; D012117:Resins, Synthetic / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*; D014498:Uracil / Q000737:chemistry*
D007555:Isoxazoles; D009705:Nucleosides; D011137:Polystyrenes; D012117:Resins, Synthetic; D014230:Triazoles; D014498:Uracil