Single-detector polarization-sensitive optical frequency domain imaging using high-speed intra A-line polarization modulation.
We demonstrate a novel high-speed polarization-sensitive optical frequency domain imaging system employing high-speed polarization modulation. Rapid and continuous polarization modulation of light prior to illumination of the sample is accomplished by shifting the frequency of one polarization eigenstate by an amount equal to one quarter of the digitization sampling frequency. This approach enables polarization-sensitive imaging with a single detection channel and overcomes artifacts that may arise from temporal variations of the birefringence in fiber-optic imaging probes and spatial variation of birefringence in the sample.
Oh
W Y
WY
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA. woh1@partners.org
Vakoc
B J
BJ
Yun
S H
SH
Tearney
G J
GJ
Bouma
B E
BE
D000818:Animals; D002645:Chickens; D003331:Coronary Vessels / Q000648:ultrastructure; D008859:Microscopy, Polarization / Q000379:methods; D018482:Muscle, Skeletal / Q000648:ultrastructure; D055095:Optics and Photonics; D013552:Swine