Three-component coupling using arynes and aminosilanes for ortho-selective double functionalization of aromatic skeletons.
Arynes were found to couple with aminosilanes and carbonyl compounds in the presence of benzoic acid to provide 2-aminobenzhydrols. Sulfonylimines could also be applied to the reaction, enabling amino and aminomethyl moieties to be incorporated into contiguous positions of aromatic skeletons. Only a small amount of the three-component coupling product was obtained in the absence of benzoic acid, which confirms its vital role in the present reaction.
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima, Japan.
Takami
T
Morishita
Hiroyuki
H
Fukushima
Hiroto
H
Yoshida
Joji
J
Ohshita
Atsutaka
A
Kunai