Chronic multi-electrode neural recording in free-roaming monkeys.
Many behaviors of interest to neurophysiologists are difficult to study under laboratory conditions because such behaviors are often inhibited when an animal is restrained and socially isolated. Even under the best conditions, such behaviors may be sparse enough as to require long duration neural recordings or simultaneous recording of multiple neurons to gather a sufficient amount of data for analysis. We have developed a preparation for chronic, multi-electrode recordings in the auditory cortex of marmoset monkeys, small primates, as well as techniques for neurophysiological recordings when the animals are free-roaming while singly caged in the environment of the monkey colony. In this report, we describe our solutions to overcome the problems associated with chronic recordings in free-roaming animals, where three-dimensional movements present particular challenges.
Eliades
Steven J
SJ
Laboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. seliades@jhu.edu
Wang
Xiaoqin
X
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001303:Auditory Cortex / Q000502:physiology; D001307:Auditory Perception / Q000502:physiology; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods; D002144:Callithrix / Q000502:physiology*; D004567:Electrodes, Implanted / Q000592:standards; D004594:Electrophysiology / Q000295:instrumentation* / Q000379:methods*; D005106:Exploratory Behavior / Q000502:physiology; D009043:Motor Activity / Q000502:physiology; D009068:Movement / Q000502:physiology; D009474:Neurons / Q000502:physiology; D009482:Neurophysiology / Q000295:instrumentation* / Q000379:methods*