Fluid dynamics of establishing left-right patterning in development.
How does the clockwise motion of tens of monocilia drive a leftward flow in the node? And, as the observed flow is leftward, how is the fluid recirculating within the node, as it must, because the node is a closed structure? How does the nodal flow lead to left-right symmetry breaking in the embryo? These questions are within the realm of fluid physics, whose application to the problem of left-right symmetry breaking in vertebrates has led to important advances in the field.
Cartwright
Julyan H E
JH
Instituto Andaluz de Ciencias de la Tierra, CSIC-Universidad de Granada, Campus Fuentenueva, E-18071 Granada, Spain. julyan@lec.csic.es
Piro
Nicolas
N
Piro
Oreste
O
Tuval
Idan
I
D000818:Animals; D001826:Body Fluids / Q000502:physiology*; D019521:Body Patterning / Q000502:physiology*; D002923:Cilia / Q000502:physiology*; D004622:Embryo, Mammalian / Q000502:physiology; D004625:Embryo, Nonmammalian / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology*; D008954:Models, Biological; D014714:Vertebrates / Q000033:anatomy & histology