Chronic Helicobacter pylori infection is associated with peripheral arterial disease.
It is reported that Helicobacter pylori infection is associated with coronary atherosclerosis both epidemiologically and pathogenetically, but no conclusions have yet been reached. Therefore, we investigated the relationship between H. pylori infection and peripheral arterial disease (PAD). Sixty-nine patients with PAD attending Harasanshin General Hospital (Fukuoka, Japan) were compared with 143 controls (age-matched asymptomatic outpatients with hyperlipidemia). H. pylori infection was diagnosed by the detection of IgG antibodies, the (13)C-urea breath test, and histological examination. Multiple logistic regression analysis was used to assess the data. The 69 PAD patients and 143 controls were aged from 50 to 92 years. According to the Fontaine classification, 43/69 PAD patients (62.3%) were grade I, 25 (36.2%) were grade II, and 1 (0.14%) was grade III. The prevalence of H. pylori infection was higher in the PAD patients than in the controls (79.7% versus 44.8%; P < 0.01). Stepwise logistic regression analysis revealed that H. pylori infection and hypertension had a significant influence on the occurrence of PAD. Our results suggest that chronic H. pylori infection may be one of the risk factors for PAD.
Sawayama
Yasunori
Y
Department of General Medicine, Kyushu University Hospital, Hakata-ku, Fukuoka 812-8582, Japan. sawayama@genmedpr.med.kyushu-u.ac.jp
Hamada
Maki
M
Otaguro
Shigeru
S
Maeda
Shinji
S
Ohnishi
Hachiro
H
Fujimoto
Yayoi
Y
Taira
Yuji
Y
Hayashi
Jun
J
D000368:Aged; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000150:complications* / Q000382:microbiology*; D012307:Risk Factors