Bone mass and bone resorption in postmenopausal women with type 2 diabetes mellitus.
The aim of the present study was to examine the relationships between bone mass or bone resorption evaluated by urinary cross-linked N-telopeptides of type I collagen (NTx) concentration and known and potential contributors to bone mass or bone resorption such as sex hormones, age, duration of diabetes, glycemic control (hemoglobin A(1c) [HbA(1c)]), body mass index (BMI), severity of diabetic complications, smoking status, and current treatment of diabetes in postmenopausal women with type 2 diabetes mellitus (n = 196). In addition, the relationship of bone mass to pulse wave velocity, which is an earlier indicator of cardiovascular disease, was investigated in a subgroup of patients (n = 120). Bone mass was evaluated by the quantitative ultrasound method. A higher stiffness index indicates higher bone mass. Inverse correlations were found between the stiffness index and age (r = -0.374, P < .0001) and between the stiffness index and log (urinary albumin excretion) (r = -0.170, P = .0398), and a positive correlation was found between the stiffness index and serum dehydroepiandrosterone sulfate (DHEA-S) concentration (r = 0.201, P = .0136). No significant correlations were found between the stiffness index and duration of diabetes, HbA(1c), BMI, or serum estradiol concentration. No significant correlations were found between urinary NTx concentration and age, duration of diabetes, HbA(1c), BMI, serum estradiol concentration, or serum DHEA-S concentration. The stiffness index correlated inversely with urinary NTx concentration (r = -0.262, P = .0002). No significant correlation was found between the stiffness index and pulse wave velocity (r = -0.165, P = .0714). Multiple regression analysis demonstrated that serum DHEA-S concentration was an independent determinant of the stiffness index (beta = .207, P = .0428). In conclusion, serum DHEA-S concentration correlated positively with bone mass, whereas glycemic control, BMI, or duration of diabetes did not correlate with bone mass or urinary NTx concentration in postmenopausal women with type 2 diabetes mellitus.
Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Hiroko
H
Hosoda
Michiaki
M
Fukui
Ichiko
I
Nakayama
Mai
M
Asano
Mayuko
M
Kadono
Goji
G
Hasegawa
Toshikazu
T
Yoshikawa
Naoto
N
Nakamura
D000368:Aged; D000375:Aging / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001862:Bone Resorption / Q000000981:diagnostic imaging / Q000473:pathology*; D001842:Bone and Bones / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000473:pathology*; D024042:Collagen Type I / Q000652:urine; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D048909:Diabetes Complications / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology*; D004958:Estradiol / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009929:Organ Size / Q000502:physiology; D010455:Peptides / Q000652:urine; D017698:Postmenopause / Q000502:physiology*; D012907:Smoking / Q000009:adverse effects; D014463:Ultrasonography
D001786:Blood Glucose; D024042:Collagen Type I; D019314:Dehydroepiandrosterone Sulfate; D004958:Estradiol; D006442:Glycated Hemoglobin; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide