Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population.
Schizophrenia has been observed to be associated with various abnormalities in cytokines and cytokine receptors. Three very recent reports showed the evidence that the IL3 gene, colony stimulating factor 2 receptor alpha (CSF2RA), beta (CSF2RB) and IL-3 receptor alpha (IL3RA), the IL-specific receptor subunits for CSF2 and IL3, respectively, are associated with schizophrenia. To examine the association of the IL3RA polymorphism (rs6603272) with schizophrenia in a Chinese population, 310 physically healthy patients with schizophrenia were compared with 330 age-, sex- matched normal controls. Statistically significant differences were observed in both allelic and genotypic frequencies of the rs6603272 polymorphism (Allele, chi2=6.24, d.f.=1, p=0.013, odds ratio (OR)=1.35, 95% CI 1.07-1.71; Genotype, chi2=6.85, d.f.=2, p=0.033). Our results indicate a small but significant contribution of the IL3RA polymorphism to susceptibility to schizophrenia, suggesting that the IL3 pathway may be involved in schizophrenia.
Research Center for Neuroscience and MH Radiobiology Research Unit, Jilin University, Changchun, PR China.
Shilong
S
Sun
Fan
F
Wang
Jun
J
Wei
Lian Yuan
LY
Cao
Gui Ying
GY
Wu
Lin
L
Lu
Therese A
TA
Kosten
Thomas R
TR
Kosten
Xiang Yang
XY
Zhang
D000483:Alleles; D044466:Asian People; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D053650:Interleukin-3 Receptor alpha Subunit / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D016185:Receptors, Interleukin-3 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
C115022:IL3RA protein, human; D053650:Interleukin-3 Receptor alpha Subunit; D016185:Receptors, Interleukin-3