Preservation of menstrual function in adolescent and young females.
Every year thousands of young teenagers are afflicted with different types of cancer and receive gonadotoxic chemotherapy and radiotherapy regimens, causing depletion of germ cells in the gonads and premature gonadal failure. In this review, we discuss and outline the current strategies and the future directions of fertility preservation and ovarian cryopreservation and transplantation in adolescents and young females.
Oktem
Ozgur
O
Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, USA.
Oktay
Kutluk
K
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D008598:Menstruation; D009369:Neoplasms / Q000628:therapy*; D010053:Ovary / Q000187:drug effects / Q000528:radiation effects; D016649:Primary Ovarian Insufficiency / Q000209:etiology*