Injection of a novel synthetic hydrogel preserves left ventricle function after myocardial infarction.
Myocardial infarction (MI) and the subsequent heart failure remain one of the leading causes of morbidity and mortality world wide. A number of studies have demonstrated that bioderived materials improve cardiac function after implantation because of their angiogenic potential. In this study, we hypothesized that injection of biomaterials into infarcted myocardium can preserve left ventricular (LV) function through its prevention of paradoxical systolic bulging. To test this hypothesis, infarction was induced in rabbit myocardium by coronary artery ligation. After 1 week, 200-microL alpha-cyclodextrin (alpha-CD)/MPEG-PCL-MPEG hydrogel was injected into the infarcted myocardium. Injection of phosphate buffered saline (PBS) served as controls. Twenty-eight days after the treatment, histological analysis indicated that the injection of hydrogel prevented scar expansion and wall thinning compared with the control (p < 0.05) without more microvessel density in infarcted myocardium (p = 0.70). LV ejection fraction, determined by echocardiography, was significantly greater in the hydrogel-treated group (56.09% +/- 8.42%) than the control group (37.26% +/- 6.36%, p = 0.001). The LV end-diastolic and end-systolic diameters were 2.07 +/- 0.33 cm and 1.74 +/- 0.30 cm, respectively, in the control group. Smaller LV end-diastolic diameter (1.61 +/- 0.26 cm, p = 0.005) and smaller end-systolic diameter (1.17 +/- 0.23 cm, p = 0.001) were found in the hydrogel-treated group. These results suggest that alpha-CD/MPEG-PCL-MPEG hydrogel could serve as an injectable biomaterial that prevents LV remodeling and dilation for the treatment of MI.
Jiang
Xue-Jun
XJ
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, People's Republic of China. xjjiang@yahoo.com
Wang
Tao
T
Li
Xiao-Yan
XY
Wu
De-Qun
DQ
Zheng
Zhao-Bin
ZB
Zhang
Jin-Feng
JF
Chen
Jin-Ling
JL
Peng
Bin
B
Jiang
Hong
H
Huang
Congxin
C
Zhang
Xian-Zheng
XZ
D000818:Animals; D001672:Biocompatible Materials; D001835:Body Weight; D002921:Cicatrix; D004452:Echocardiography / Q000379:methods; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008833:Microcirculation; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism; D011091:Polyesters / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011817:Rabbits; D016277:Ventricular Function, Left
D001672:Biocompatible Materials; D020100:Hydrogels; D011091:Polyesters; C000593606:methoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-methoxy poly(ethylene glycol); D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols