Charge dependence of ligand release and monolayer stability of gold nanoparticles by biogenic thiols.
The effect of surface charge on the stability of gold nanoparticles (AuNPs) to the biogenic thiols glutathione (GSH), dihydrolipoic acid (DHLA), and cysteine was quantified. It was observed that the rate of release of fluorescein-tagged ligand was determined by the surface charge of the AuNPs, with cationic particles much more labile than anionic analogues. This ability to tune stability is significant for the design of both delivery vehicles and intracellular probes.
Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.
Apiwat
A
Chompoosor
Gang
G
Han
Vincent M
VM
Rotello
D003545:Cysteine / Q000378:metabolism; D004337:Drug Carriers / Q000378:metabolism*; D005471:Fluoroscopy; D005978:Glutathione / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D042541:Intracellular Space / Q000378:metabolism; D008024:Ligands; D053768:Metal Nanoparticles / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013499:Surface Properties; D008063:Thioctic Acid / Q000031:analogs & derivatives / Q000378:metabolism
D004337:Drug Carriers; D008024:Ligands; D013438:Sulfhydryl Compounds; D008063:Thioctic Acid; D006046:Gold; C015144:dihydrolipoic acid; D005978:Glutathione; D003545:Cysteine