Prevalence of antibodies in response to Legionella species, analysis of a healthy population from Jeollanam-do Province, Korea.
Seroepidemological investigation of antibodies to Legionella species in 500 healthy individuals from a single geographical location in Korea was conducted by indirect fluorescent antibody assay (IFA). Considering an antibody titer of > or =1:128 as positive reaction, 15.2% of total sera were positive. In males and females older than 40 years old, levels of IgM and IgG were 1.2% and 14%, respectively. The sera with antibody titers of > or =1:128 to Legionella species accounted for 85 sera, and 9 sera of these were reacted to more than one Legionella species. Reactivity to L. bozemanii, L. micdadei, L. longbeachae, L. pneumophila sg 6, and L. gormanii were 32.9%, 20%, 15%, 10.6%, and 8%, respectively. However, L. pneumophila sg 1, sg 2, and sg 3 did not react to any sera. Serological analysis revealed that the level of antibody in response to L. bozemanii was more prevalent than L. pneumophila. Our results suggest that the antibodies of non-L. pneumophila species, such as L. bozemanii, may be highly prevalent in healthy population within Korea. Although conclusions based on the findings of this study must be cautiously considered given that the population sampled were sourced from a single province, we have added to the knowledge base of serodiagnosis of infections due to non-L. pneumophila species in Korea.
Lee
Hae Kyung
HK
Division of Bacterial Respiratory Infections, Center for Infectious Diseases, National Institute of Health, Centers for Disease Control and Prevention, Seoul, 122-701, Republic of Korea.
Woo
Mi Kyeong
MK
Ju
Yong In
YI
Baek
Soo Jin
SJ
Song
Hyeon Je
HJ
Choi
Jin Su
JS
Kweon
Sun Seog
SS
Jeon
Doo Young
DY
Kang
Yeon Ho
YH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D002648:Child; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006262:Health; D006801:Humans; D007723:Korea / Q000453:epidemiology; D007875:Legionella / Q000276:immunology*; D007876:Legionellosis / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D016036:Seroepidemiologic Studies
D000907:Antibodies, Bacterial