Formulation and evaluation of ciprofloxacin hydrochloride soluble ocular drug insert.
OBJECTIVE
An attempt has been made in the present research to formulate soluble ocular inserts of ciprofloxacin hydrochloride to increase residence time and prolong drug release.


METHODS
Drug matrices were prepared using natural polymer. Gelatin, a biodegradable polymer, was tried for the first time in the preparation of soluble ocular drug insert matrices. The inserts were then evaluated for their physicochemical parameters. The in vitro drug release studies were carried out using a bi-chambered donor receiver compartment model. In vivo drug release was carried out using rabbits as animal models.


RESULTS
Formulations CF4 and CF8, which showed controlled and prolonged in vitro drug release, were subjected to in vivo study. In vitro and in vivo correlation was found to be strong, revealing the efficacy of the formulation.


CONCLUSIONS
Formulation CF8 was found promising, as it achieved the target of the present study.
Mundada
A S
AS
University Department of Pharmaceutical Sciences, R.T.M. Nagpur University, Nagpur, India. atishmundada@rediffmail.com
Shrikhande
B K
BK
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry* / Q000633:toxicity; D001672:Biocompatible Materials; D002626:Chemistry, Pharmaceutical; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000737:chemistry* / Q000633:toxicity; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004355:Drug Stability; D005780:Gelatin; D004364:Pharmaceutical Preparations; D011817:Rabbits
D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D002939:Ciprofloxacin; D005780:Gelatin