Clinicopathologic features and treatment outcomes in Woringer-Kolopp disease.
Woringer-Kolopp disease, also known as pagetoid reticulosis, is an exceedingly rare variant of mycosis fungoides. Accurate diagnosis and effective treatment is essential to prevent progression to debilitating disease. We identified 7 patients with Woringer-Kolopp disease treated at our institution. We review the major clinical and pathologic characteristics of this disease, focusing on treatment strategies and patient outcomes. All of our patients were successfully treated with skin-directed therapies including topical steroids, topical nitrogen mustard, psoralen plus ultraviolet A, narrow-band ultraviolet B, and radiation therapy. Our observations confirm that Woringer-Kolopp disease carries an excellent prognosis, and support that the most effective and appropriate treatment for recalcitrant or severe Woringer-Kolopp disease is localized radiation therapy.
Department of Dermatology, Stanford University School of Medicine, Stanford, California 94305, USA.
Juliette
J
Lee
Natalie
N
Viakhireva
Christine
C
Cesca
Percy
P
Lee
Sabine
S
Kohler
Richard T
RT
Hoppe
Youn H
YH
Kim
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006229:Hand Dermatoses / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage; D009182:Mycosis Fungoides / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D011701:PUVA Therapy; D017785:Photons / Q000627:therapeutic use; D011829:Radiation Dosage; D016879:Salvage Therapy; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D016896:Treatment Outcome
D008466:Mechlorethamine