Acquired hemophilia in a patient with systemic lupus erythematosus: a case report and literature review.
We report the case of a 38-year-old female patient with systemic lupus erythematosus (SLE) who developed acquired hemophilia caused by factor VIII (FVIII) inhibitors. She manifested spontaneous bleeding symptoms such as ecchymoses and hematuria. Laboratory findings showed an isolated prolongation of the activated partial thromboplastin time, reduced FVIII activity, and a high titer of FVIII inhibitors. She was successfully treated with oral predonisolone and cyclosporine in combination with steroid and cyclophosphamide pulse therapy.
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, and Department of Internal Medicine, Chihaya Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. akahoshi@intmed1.med.kyushu-u.ac.jp
Mitsuteru
M
Akahoshi
Kumiko
K
Aizawa
Shuji
S
Nagano
Hisako
H
Inoue
Atsushi
A
Sadanaga
Yojiro
Y
Arinobu
Hiroaki
H
Niiro
Hitoshi
H
Nakashima
D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D004438:Ecchymosis / Q000209:etiology; D005169:Factor VIII / Q000276:immunology*; D005260:Female; D006467:Hemophilia A / Q000150:complications / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology*
D001323:Autoantibodies; D005169:Factor VIII