BanI polymorphism of cytosolic phospholipase A2 gene is associated with age at onset in male patients with schizophrenia and schizoaffective disorder.
The enzymes phospholipases A2 are believed to be involved in the pathology of schizophrenia. We investigated allelic and genotype frequencies of PLA2G4A BanI polymorphism and the rs4375 in PLA2G6A in Croatian schizophrenic patients (n=81) and controls (n=182), using PCR/RFLP. Genotype and allelic frequencies of both loci, alone or in combination did not show significant difference (chi2-test). Allele-wise and genotype-wise meta-analyses of BanI polymorphism in case-control and family-based studies also revealed no significant association with schizophrenia. Multiple logistic regression analyses revealed statistically significant association between several items from PANSS general psychopathology scale and BanI polymorphism in PLA2G4A. BanI polymorphism further showed a significant impact on mean age of the onset of disease in males (betaA1=0.351, P=0.021; Spearman's rA1=0.391, P=0.010) indicating lower mean age at admission in homozygous A2A2 males.
Nadalin
S
S
Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Croatia.
Rubesa
G
G
Giacometti
J
J
Vulin
M
M
Tomljanović
D
D
Vraneković
J
J
Kapović
M
M
Buretić-Tomljanović
A
A
D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D017523:Croatia / Q000453:epidemiology; D004247:DNA / Q000235:genetics / Q000378:metabolism; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism*; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D054513:Group IV Phospholipases A2 / Q000235:genetics; D054522:Group VI Phospholipases A2 / Q000235:genetics; D006801:Humans; D016015:Logistic Models; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D054510:Phospholipases A2, Cytosolic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011618:Psychotic Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*
D004247:DNA; D054513:Group IV Phospholipases A2; D054522:Group VI Phospholipases A2; C516389:PLA2G4A protein, human; C516475:PLA2G6 protein, human; D054510:Phospholipases A2, Cytosolic; C051612:endodeoxyribonuclease BanI; D015252:Deoxyribonucleases, Type II Site-Specific