Cyclic Disulfides as Functional Mimics of the Histone Deacetylase Inhibitor FK-228.
FK-228 is a potent histone deacetylase (HDAC) inhibitor with tremendous therapeutic potential against a wide array of human cancers. We describe the development of analogs that share FK-228's novel mechanism of activation and HDAC inhibition.
School of Pharmacy, University of Wisconsin, Madison, WI 53705.
Jared R
JR
Mays
José A
JA
Restituyo
Rebeccah J
RJ
Katzenberger
David A
DA
Wassarman
Scott R
SR
Rajski