A convenient synthesis and the asymmetric hydrogenation of N-phthaloyl dehydroamino acid esters.
A convenient synthetic method was reported for the preparation of N-phthaloyl dehydroamino acid esters from easily accessible vinyl bromides (or vinyl tosylate) and potassium phthalimide. Rh-catalyzed asymmetric hydrogenation of these substrates with TangPhos gave the products with good to excellent enantioselectivities (up to 99% ee).
Chen
Jian
J
College of Chemistry and Molecular Sciences, Wuhan University, P.R. China.
Liu
Qiang
Q
Zhang
Weicheng
W
Spinella
Stephen
S
Lei
Aiwen
A
Zhang
Xumu
X
D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004952:Esters; D006865:Hydrogenation; D015394:Molecular Structure; D010795:Phthalic Acids / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000737:chemistry
D000596:Amino Acids; D004952:Esters; D010795:Phthalic Acids; D014753:Vinyl Compounds; D012238:Rhodium