[Aspergillosis of masticator space including mandibular bone responding to itraconazole treatment in a diabetic adult: case report].
Aspergillosis of the bone is rare and resistant to treatment. We report a case of Aspergillus infection of the masticator space including mandibular bone in a diabetic adult. After extraction of a posterior tooth, the patient began to suffer from facial pain. The pain worsened in spite of antibiotic treatment. The results of serum tests and biopsy showed an invasive aspergillosis of the left masticator space including the mandibular bone six months after the onset. Although invasive aspergillosis can be fatal, the infection in our case responded to itraconazole treatment. Even in diabetes mellitus, invasive aspergillosis may occur after surgical interventions such as tooth extraction.
Department of Hematology, Kumamoto University Graduate School of Medical Sciences.
Kentaro
K
Horikawa
Hironori
H
Kudo
Sonoko
S
Ishihara
Toshikazu
T
Miyakawa
Tatsuya
T
Kawaguchi
Hiroaki
H
Mitsuya
D000284:Administration, Oral; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage*; D001228:Aspergillosis / Q000188:drug therapy* / Q000209:etiology*; D048909:Diabetes Complications; D004334:Drug Administration Schedule; D006801:Humans; D016867:Immunocompromised Host; D007262:Infusions, Intravenous; D017964:Itraconazole / Q000008:administration & dosage*; D008297:Male; D008336:Mandibular Diseases / Q000188:drug therapy* / Q000209:etiology*; D008410:Masticatory Muscles; D014081:Tooth Extraction / Q000009:adverse effects*; D016896:Treatment Outcome
D000935:Antifungal Agents; D017964:Itraconazole