Cervical phosphorylated insulin-like growth factor binding protein-1 in prediction of preterm delivery.
BACKGROUND
The aim of this study was to evaluate the phosphorylated isoform of insulin-like growth factor binding protein-1 (phIGFBP-1) in endocervical secretions as a predictor of preterm delivery in symptomatic and asymptomatic pregnant women.


METHODS
The study included 105 patients between 24 and 34 weeks' gestation with uterine contractions and 73 controls. Ph IGFBP-1 in cervical secretions was assessed in all patients by using a qualitative, immunochromatographic one-step dipstick test. Data analysis included Student's test, Chi-Square, Fisher's exact test and Kruskal Wallis variance analysis.


RESULTS
Preterm birth rate was 19.04% (20/105) in the study group. Of the 25 patients with a positive phIGFBP-1 test, mean gestational age at delivery was 32.8+/-3.8, whereas of the 80 patients with a negative phIGFBP-1 test mean gestational age at delivery was 37.8+/-2.5, in the study group (P<0.05). The sensitivity, specificity, positive predictive value and negative predictive value for phIGFBP-1 in symptomatic patients were 70, 87.05, 56 and 92.5%, respectively, while in asymptomatic patients they were 40, 82.35, 14.28 and 94.91%, respectively.


CONCLUSIONS
The phIGFBP-1 in cervical secretions is a potential specific marker for preterm delivery occurring before 37 weeks. Also cervical detection of phIGFBP-1 by immunochromatography is a rapid and easily applicable test that highly predicts preterm delivery.
Altinkaya
Ozlem
O
Zekai Tahir Burak Women's Health Care Research and Education Hospital, Ankara, Turkey. altinkayaozlem@yahoo.com
Gungor
Tayfun
T
Ozat
Mustafa
M
Danisman
Nuri
N
Mollamahmutoglu
Leyla
L
D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001724:Birth Weight; D002584:Cervix Uteri / Q000378:metabolism*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D010766:Phosphorylation; D011237:Predictive Value of Tests; D011247:Pregnancy; D047928:Premature Birth / Q000378:metabolism*; D020033:Protein Isoforms; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D055815:Young Adult
D015415:Biomarkers; D018970:Insulin-Like Growth Factor Binding Protein 1; D020033:Protein Isoforms