Nodular scleritis following alendronate therapy.
OBJECTIVE
To report a case of nodular scleritis following alendronate sodium.


METHODS
A 54 year-old male was treated with alendronate sodium 70 mg orally once per week. Eight weeks later, he experienced pain and redness of the right eye. Biomicroscopy was performed.


RESULTS
Patient was found to have inferonasal nodular scleritis. Laboratory work-up was unrevealing. Patient was given 4 mg of subtenon's triamcinolone acetate in the area of the nodular scleritis and had complete resolution. Two weeks following rechallenge with alendronate sodium resulted in recurrence of his scleritis.


CONCLUSIONS
Alendronate led to nodular scleritis and rechallenge caused recurrence of scleritis.
Tabbara
Khalid F
KF
Eye Center and the Eye Foundation for Research in Ophthalmology, Riyadh, Saudi Arabia. k.tabbara@nesma.net.sa
D019386:Alendronate / Q000009:adverse effects* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D050071:Bone Density Conservation Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D015423:Scleritis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome; D014221:Triamcinolone / Q000008:administration & dosage / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D050071:Bone Density Conservation Agents; D014221:Triamcinolone; D019386:Alendronate