Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication.
Lead manifests toxic effects in almost all organs and tissues, especially in: the nervous system, hematopoietic system, kidney and liver. This metal has a special affinity for deposition in hard tissue, i.e., bones and teeth. It is generally believed that the main mechanism of its toxicity relies on its interaction with bioelements, especially with Ca and Mg. This article analyses the influence of Pb poisoning on Ca and Mg content in hard tissues, (mandible, femur, teeth and skull) of female and young rats. Experiments were carried out on 60 female rats, AO breed, and on 80 of their young rats (offspring). Female rats were divided into three groups: the first one was a control group, the second one received 100 mg/kg Pb2+ kg b.wt. per day in drinking water, the third one received 30 mg/kg Pb(2+) kg b.wt. per day in drinking water. Young rats (offspring) were divided into the same respective three groups. Lead, calcium and magnesium content in hard tissues (mandible, femur, teeth-incisors and skull) was determined by flame atomic absorption spectrophotometry in mineralized samples. There was a statistically significant Pb deposition in all analyzed female and young rat hard tissues. Ca and Mg contents were significantly reduced in all female and young rat hard tissues. These results show that Pb poisoning causes a significant reduction in Ca and Mg content in animal hard tissues, which is probably the consequence of competitive antagonism between Pb and Ca and Mg.
Todorovic
Tatjana
T
School of Dentistry, Department of Biochemistry, University of Belgrade, 11000 Belgrade, Dr Subotica 1, Serbia. tanja.todorovic@stomf.bg.ac.yu
Vujanovic
Dragana
D
Dozic
Ivan
I
Petkovic-Curcin
Aleksandra
A
D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D005260:Female; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007854:Lead / Q000633:toxicity*; D007855:Lead Poisoning / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008274:Magnesium / Q000097:blood / Q000378:metabolism*; D008334:Mandible / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D012886:Skull / Q000187:drug effects / Q000378:metabolism; D014070:Tooth / Q000187:drug effects / Q000378:metabolism
D007854:Lead; D008274:Magnesium; D002118:Calcium