Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss.
We performed a retrospective diagnostic study of congenital cytomegalovirus (CMV) infection in patients with sensorineural hearing loss (SNHL). CMV DNA in preserved umbilical cords was analyzed using real-time polymerase chain reaction analysis. Of 45 analyzable patients with SNHL, CMV DNA was detected in the preserved umbilical cords of 3 patients, all of whom had bilateral SNHL that lacked a clear onset period. CMV DNA was not detected in any of the patients with sudden SNHL or enlarged vestibular aqueduct-associated SNHL. The features of CMV-associated SNHL were more asymmetric than those of CMV-negative bilateral SNHL.
Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, Nagoya, Japan. mizuteru@med.nagoya-u.ac.jp
Terukazu
T
Mizuno
Saiko
S
Sugiura
Hiroshi
H
Kimura
Yoshihiro
Y
Ando
Michihiko
M
Sone
Yukihiro
Y
Nishiyama
Tsutomu
T
Nakashima
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000151:congenital / Q000453:epidemiology* / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics*; D007758:Ear, Inner / Q000821:virology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013701:Temporal Bone / Q000821:virology; D014470:Umbilical Cord / Q000821:virology*; D055815:Young Adult
D004279:DNA, Viral