Characteristics of the beta-globin gene cluster haplotypes of three Han Chinese populations at Beijing, Xi'an, and Kunming as compared with those of other Asian populations.
Haplotype frequencies of the beta-globin gene cluster of Han Chinese at Beijing, Xi'an, and Kunming were estimated, and their mutual genetic relationships were examined and compared to those of Buryats, Khalkhs, Evenkis, Oroqens, Koreans, and Colombian Amerindians. A major 5' subhaplotype (5' to the delta-globin gene), a major 3' subhaplotype (in and 3' to the beta-globin gene), and a major haplotype (combination of 5' and 3' subhaplotypes) are represented as + - - - -, - +, and + - - - - - +, respectively, and found in all three Han Chinese. A rare 5' subhaplotype, - - - - -, which is one of the possible ancestral types, was found only in Han Chinese at Kunming at low frequency (0.013), and a rare 3' subhaplotype, - -, was also observed in all three Han Chinese at low frequencies (0.009-0.014). The present haplotype frequency study suggested that the highest genetic affinity was found between Han Chinese at Beijing and those at Xi'an; the next highest was between Han Chinese at Beijing and Koreans, followed by that between Han Chinese at Beijing and Khalkhs, then that between Han Chinese at Xi'an and those at Kunming or Khalkhs, and finally that between Han Chinese at Beijing and those at Kunming. A genetic boundary between northern and southern Han Chinese was not evident in the present study.
Shimizu
Koji
K
Laboratory of Biology, Naruto University of Education, Tokushima, 772-8502, Japan. shimizuk@naruto-u.ac.jp
Nagaoka
Erika
E
Okada
Yusuke
Y
Takeuchi
Yukiko
Y
Harihara
Shinji
S
Omoto
Keiichi
K
Imanishi
Tadashi
T
Kim
Wook
W
Shin
Dong-Jik
DJ
Hao
Luping
L
Jin
Feng
F
D002681:China / Q000208:ethnology; D005006:Ethnicity; D005787:Gene Frequency; D005828:Genetics, Population; D005843:Geography; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D005810:Multigene Family; D010802:Phylogeny; D055544:beta-Globins / Q000235:genetics*
D055544:beta-Globins