[Significance of id4 promoter methylation in monitoring AML patients with completely remission].
The study was purposed to investigate the significance of id4 gene promoter methylation in monitoring AML patients with complete remission (CR). Methylation specific-PCR (MS-PCR) were used to detect the status of promoter methylation of id4 gene in bone marrow samples from AML patients with CR who had accepted induction with DA or IA and 4 to 5 consolidation chemotherapy with Ara-C. The results showed that in the all 32 patients, 15 were found to show id4 promoter methylation and 7 out of the 15 were found relapsed or tendency to relapse in the following-up period. While all the 17 patients with id4 unmethylation were still in their CR status in the same period. In conclusion, id4 promoter methylation might be a predictor for relapse of AML patients with CR in certain degree.
Department of Hematology, General Hospital of PLA, Beijing 100853, China.
Yu
Y
Zhao
Quan-Shun
QS
Wang
Hong-Hua
HH
Li
Jian
J
Bo
Li-Ping
LP
Dou
Yu
Y
Jing
Shu-Hong
SH
Wang
Li
L
Yu
D019175:DNA Methylation; D006801:Humans; D051796:Inhibitor of Differentiation Proteins / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000378:metabolism*; D018365:Neoplasm, Residual / Q000175:diagnosis* / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics*
C490128:ID4 protein, human; D051796:Inhibitor of Differentiation Proteins