Bridging Toll-like- and B cell-receptor signaling: meet me at the autophagosome.
In this issue of Immunity, Chaturvedi et al. (2008) describe a mechanism for the bridging of innate and adaptive immune receptor functions. In their model, B cell-receptor signaling induces the fusion of Toll-like receptor 9 (TLR9)-containing endosomes with internalized signaling-competent BCR into autophagosomes.
Monroe
John G
JG
Genentech, Inc., 1 DNA Way, MS 93b, South San Francisco, CA 94080, USA. monroe.john@gene.com
Keir
Mary E
ME
D000818:Animals; D015551:Autoimmunity; D006801:Humans; D008213:Lymphocyte Activation; D010588:Phagosomes / Q000276:immunology / Q000378:metabolism*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D051217:Toll-Like Receptor 9 / Q000276:immunology / Q000378:metabolism*
D011947:Receptors, Antigen, B-Cell; D051217:Toll-Like Receptor 9