Rapid regression of duodenal inflammatory myofibroblastic tumor after intravenous ketorolac: case report and review of the literature.
Inflammatory myofibroblastic tumors are known to sometimes regress spontaneously or in response to treatment with antiinflammatory drugs. We present the case of a 13-year-old boy with an inflammatory myofibroblastic tumor of the proximal duodenum, which regressed rapidly within days of an open surgical biopsy, resulting in perforation of the duodenum. Ketorolac was administered intravenously after the biopsy and is implicated as a potential cause of the rapid regression of the tumor. We discuss the surgical management of this patient and present a review of the literature.
General, Thoracic and Fetal Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. mattei@email.chop.edu
Peter
P
Mattei
Karen
K
Barnaby
D000293:Adolescent; D001707:Biopsy, Needle; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006104:Granuloma, Plasma Cell / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007262:Infusions, Intravenous; D020910:Ketorolac / Q000008:administration & dosage*; D007813:Laparotomy / Q000379:methods; D008297:Male; D009379:Neoplasms, Muscle Tissue / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D020910:Ketorolac