Ritonavir-boosted atazanavir, methadone, and ventricular tachycardia: 2 case reports.
We describe 2 cases of symptomatic ventricular tachycardia associated with prolonged QT interval. Both patients were infected with the human immunodeficiency virus and were receiving treatment with ritonavir-boosted atazanavir and methadone. Discontinuation of atazanavir in both cases resulted in a reduction in the QT interval and cessation of arrhythmia. We concluded that atazanavir contributed to prolonged corrected QT interval and subsequent ventricular tachycardia.
Department of 1Infectious Diseases, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland. davgallagher@gmail.com
David P
DP
Gallagher
Jennifer
J
Kieran
Gerard
G
Sheehan
John
J
Lambert
Niall
N
Mahon
Patrick W G
PW
Mallon
D000328:Adult; D000069446:Atazanavir Sulfate; D004359:Drug Therapy, Combination; D004562:Electrocardiography / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D008875:Middle Aged; D009294:Narcotics / Q000627:therapeutic use; D009842:Oligopeptides / Q000009:adverse effects*; D011725:Pyridines / Q000009:adverse effects*; D019438:Ritonavir / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000139:chemically induced*
D017320:HIV Protease Inhibitors; D009294:Narcotics; D009842:Oligopeptides; D011725:Pyridines; D000069446:Atazanavir Sulfate; D019438:Ritonavir; D008691:Methadone