Increase of Dkk-3 blood plasma levels in the elderly.
Gene expression of the secreted glycoprotein Dkk-3 is upregulated during cellular senescence in prostate basal epithelial cells and altered in age-related disorders of the human prostate. In order to quantify the influence of such age- and disease-related changes of Dkk-3 levels in body fluids, we established a highly specific and sensitive indirect IEMA. Results revealed a significant increase of Dkk-3 blood plasma levels in the elderly (1.17+/-0.36 vs. 1.61+/-0.61 nmol/L) indicating a non-negligible physiological role and its use as a marker for senescence not only in vitro but also in vivo.
Endocrinology Division, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, Innsbruck A-6020, Austria.
Christoph
C
Zenzmaier
Lilian
L
Sklepos
Peter
P
Berger
D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D000911:Antibodies, Monoclonal / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D018925:Chemokines; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood* / Q000276:immunology; D008297:Male; D012680:Sensitivity and Specificity; D055815:Young Adult
D048868:Adaptor Proteins, Signal Transducing; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D018925:Chemokines; C498624:DKK3 protein, human; D036341:Intercellular Signaling Peptides and Proteins