HOming in on arteriovenous fistula survival.
Vascular access failure is a major clinical problem for patients on hemodialysis, but therapeutic approaches aimed at improving arteriovenous fistula (AVF) dysfunction remain elusive. Using a murine AVF model, Juncos et al. demonstrate for the first time that the stress protein heme oxygenase-1 (HO-1) is induced in AVFs and that HO-1 is a critical determinant of AVF survival.
Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, Missouri 65212, USA. durantew@health.missouri.edu
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D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D002408:Catheters, Indwelling / Q000592:standards*; D005786:Gene Expression Regulation; D051547:Heme Oxygenase-1 / Q000235:genetics*; D006801:Humans; D006435:Renal Dialysis
D051547:Heme Oxygenase-1