The molecular genetics of laryngeal cancer.
The authors present the clinical relevance of molecular genetics to laryngeal cancer in terms of helping to develop novel diagnostic, prognostic, and therapeutic strategies. They discuss how molecular diagnostics can detect abnormalities in lesions not yet appreciated histologically, and thus detect early recurrences. Patient management with novel targeted therapies for head and neck squamous cell carcinoma in the clinical arena is presented, with treatment options tailored to the individual patient and his or her cancer among them, with the goal of improving clinical outcomes.
Loyo
Myriam
M
Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, USA.
Pai
Sara I
SI
D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D004252:DNA Mutational Analysis; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D020868:Gene Silencing; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D009363:Neoplasm Proteins / Q000235:genetics; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D019139:Tumor Escape / Q000235:genetics
D009363:Neoplasm Proteins