Peptide YY: a gut hormone associated with anorexia during infectious diarrhea in children.
OBJECTIVE
To evaluate the effects of diarrhea on appetite among Peruvian children age 12 to 71 months and to assess whether elevated plasma levels of peptide YY, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1beta contribute to anorexia in this population.


METHODS
A total of 46 Peruvian children with diarrhea and 46 healthy controls underwent an observed feeding trial that was repeated when cases were healthy. Blood samples were obtained from 30 cases and 30 controls at the first trial and from 30 cases at the second trial and assayed for peptide YY, TNF-alpha, and IL-1beta.


RESULTS
In the cases, mean consumption was less when sick than when healthy. The mean plasma level of peptide YY was higher for cases than controls and higher for cases when sick than when healthy. TNF-alpha levels were higher in cases than controls at visit 1 and also higher in cases when sick than when healthy. There were no differences in IL-1beta levels between cases and controls or between cases when sick and healthy. Peptide YY levels in children with diarrhea correlated with the likelihood of them eating less when sick than when healthy.


CONCLUSIONS
Elevated serum peptide YY may be a mechanism for anorexia in children with diarrhea.
From the Department of Pediatrics, University of California San Francisco, San Francisco, CA.
Amy L
AL
Beck
Lilia
L
Cabrera
William K Y
WK
Pan
Vitaliano
V
Cama
Jon S
JS
Friedland
Mohammad A
MA
Ghatei
Stephen R
SR
Bloom
Judy
J
Lewis
Robert H
RH
Gilman
D000855:Anorexia / Q000150:complications* / Q000378:metabolism; D001066:Appetite; D016022:Case-Control Studies; D002675:Child, Preschool; D003967:Diarrhea / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D005260:Female; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D006801:Humans; D007223:Infant; D053583:Interleukin-1beta / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D019894:Peptide YY / Q000378:metabolism / Q000502:physiology*; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D005768:Gastrointestinal Hormones; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D019894:Peptide YY