Geometry shapes cell signaling network output.
Through live cell imaging and computational modeling, Neves et al. (2008) demonstrate that molecular interactions alone are insufficient to explain the patterns of MAPK activation: a model must include the cell morphology and spatial distribution of signaling molecules.
Holmes
Raquell M
RM
University of Connecticut Health Center, Center for Cell Analysis and Modeling, Farmington, CT 06032-1507, USA. rholmes@uchc.edu
Loew
Leslie M
LM
D019295:Computational Biology; D004789:Enzyme Activation; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D015398:Signal Transduction; D013379:Substrate Specificity
D020928:Mitogen-Activated Protein Kinases