The nature of the sensitiser substituent determines quenching sensitivity and protein affinity and influences the design of emissive lanthanide complexes as optical probes for intracellular use.
Introduction of different substituents at the 7-position of a sensitising azaxanthone group in a series of emissive Eu and Tb complexes can determine the intracellular uptake and distribution profile and may be linked to modulation of protein affinity.
Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
Filip
F
Kielar
Ga-Lai
GL
Law
Elizabeth J
EJ
New
David
D
Parker
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005063:Europium / Q000737:chemistry; D006801:Humans; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism*; D028581:Lanthanoid Series Elements / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity; D055095:Optics and Photonics; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity; D011485:Protein Binding; D012680:Sensitivity and Specificity; D013725:Terbium / Q000737:chemistry
D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds; D013725:Terbium; D005063:Europium