Effect of silver-doped phosphate-based glasses on bacterial biofilm growth.
Silver-containing phosphate-based glasses were found to reduce the growth of Pseudomonas aeruginosa and Staphylococcus aureus biofilms, which are leading causes of nosocomial infections. The rates of glass degradation (1.27 to 1.41 microg.mm(-2).h(-1)) and the corresponding silver release were found to account for the variation in biofilm growth inhibitory effect.
Division of Biomaterials and Tissue Engineering, University College London, London, United Kingdom.
Sabeel P
SP
Valappil
Jonathan C
JC
Knowles
Michael
M
Wilson
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001422:Bacterial Adhesion; D018441:Biofilms / Q000187:drug effects*; D005898:Glass / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000502:physiology; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology
D000900:Anti-Bacterial Agents; D010710:Phosphates; D012834:Silver