Structure and dynamic regulation of Src-family kinases.
Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src family share the same domain organization, with modular SH3, SH2 and kinase domains followed by a C-terminal negative regulatory tail. X-ray crystallographic analyses of several Src family members have revealed critical roles for the SH3 and SH2 domains in the down-regulation of the kinase domain. This review focuses on biological, biophysical, and computational studies that reveal conformationally distinct active states within this unique kinase family.
Engen
J R
JR
Department of Chemistry and Chemical Biology and the Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, Massachusetts, 02115, USA.
Wales
T E
TE
Hochrein
J M
JM
Meyn
M A
MA
Banu Ozkan
S
S
Bahar
I
I
Smithgall
T E
TE
D000818:Animals; D004789:Enzyme Activation; D006801:Humans; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D018909:src Homology Domains; D019061:src-Family Kinases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
D019061:src-Family Kinases