Immunohistochemical analysis of gamma catenin in Wilms' tumors.
The aim of our study was to investigate the expression of gamma-catenin in normal kidney and in Wilms' tumor by immunohistochemistry and to correlate the results with tumor stage, histological type, and prognostic group. We investigated 28 cases of Wilms' tumor, 2 Wilms' tumor metastases in lungs, and 1 specimen of normal renal tissue. Expression of gamma-catenin was detected in 14 cases. There was a weak inverse relationship between gamma-catenin expression and tumor stage. Expression of gamma-catenin was detected in various histologic types of Wilms' tumor, but there was no statistically significant correlation, except in cases with diffuse anaplasia that were negative. In 2 metastatic cases and in the case of bilateral Wilms' tumor gamma-catenin immunostaining was not observed Our findings suggest an absence of strong correlation between the loss of gamma-catenin and unfavorable outcome.
Institute of Pathology, School of Medicine, University of Belgrade, Belgrade, Serbia.
Gordana
G
Basta-Jovanovic
Eleonora
E
Gvozdenovic
Ivan
I
Dimitrijevic
Dimitrije
D
Brasanac
Milena
M
Jovanovic
Nevena
N
Kalezic
Ivana
I
Baralic
Sanja
S
Radojevic-Skodric
Dejan
D
Arsic
D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D051180:Desmoplakins / Q000378:metabolism*; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods; D007223:Infant; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology; D008175:Lung Neoplasms / Q000378:metabolism / Q000556:secondary; D008297:Male; D009367:Neoplasm Staging; D009396:Wilms Tumor / Q000378:metabolism* / Q000556:secondary; D051185:gamma Catenin
D014408:Biomarkers, Tumor; D051180:Desmoplakins; C495292:JUP protein, human; D051185:gamma Catenin