Protection of a polysaccharide from Salvia miltiorrhiza, a Chinese medicinal herb, against immunological liver injury in mice.
This study was designed to evaluate the hepatoprotective effects of S. miltiorrhiza polysaccharides (SMPS) in immunological liver injury induced by Bacille-Calmette-Guerin (BCG) and lipopolysaccharide (LPS) in mice. SMPS effectively improved the liver index, spleen index and thymus index, reduced the serum levels of alanine aminotransferase, aspartate aminotransferase and nitric oxide, and restored liver homogenate contents of tumor necrosis factor-alpha and interleukin-1beta. The histopathological analysis suggested that SMPS reduced the degree of liver injury. The results suggest that SMPS play a protective role against immunological liver injury, which may have important implications for our understanding on the immunoregulatory mechanisms of polysaccharides.
Song
Yu-Hong
YH
Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Liu
Qiang
Q
Lv
Zhi-Ping
ZP
Chen
Yu-Yao
YY
Zhou
Ying-Chun
YC
Sun
Xue-Gang
XG
D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D053583:Interleukin-1beta / Q000378:metabolism; D008070:Lipopolysaccharides / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000276:immunology / Q000293:injuries; D008107:Liver Diseases / Q000097:blood / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009163:Mycobacterium bovis / Q000276:immunology; D009569:Nitric Oxide / Q000097:blood; D010936:Plant Extracts / Q000737:chemistry*; D011134:Polysaccharides / Q000494:pharmacology*; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D013154:Spleen / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D010936:Plant Extracts; D011134:Polysaccharides; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase