Effect of levetiracetam on the postmastectomy pain syndrome.
OBJECTIVE
The aim of this randomized, double-blind, placebo-controlled, cross-over study was to test whether levetiracetam relieves the postmastectomy pain syndrome (PMPS).


METHODS
Postmastectomy pain syndrome was defined as pain of neuropathic character located in the area of the surgery and/or the ipsilateral arm. The inclusion criteria were: age more than 18 years, characteristic symptoms corresponding to PMPS more than 6 months after surgery for breast cancer, pain duration more than 3 months, peripheral nerve lesions confirmed by abnormal neurological and quantitative sensory tests, intensity of pain more than 4 on a numeric rating scale from 0 to 10 and pain present at least 4 days a week.


RESULTS
Forty-nine patients were screened for participation and 27 patients were included in the study. Twenty-five patients completed two treatment phases of 4 weeks duration with levetiracetam (3000 mg/day) and placebo. There was no difference in the rating of pain relief between treatment with levetiracetam (P = 0.83) and placebo nor when adjusted for possible period effect (P = 0.60). Analysis defining response as pain relief more than 4 on an eleven-point numeric rating scale showed no significant difference between treatment with levetiracetam and placebo (P = 1.00).


CONCLUSIONS
Levetiracetam apparently does not relieve peripheral neuropathic pain in PMPS.
Department of Neurology, Odense University Hospital, Odense, Denmark. vilholm@dadlnet.dk
O J
OJ
Vilholm
S
S
Cold
L
L
Rasmussen
S H
SH
Sindrup
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D008408:Mastectomy / Q000009:adverse effects*; D008875:Middle Aged; D009437:Neuralgia / Q000188:drug therapy*; D010149:Postoperative Pain / Q000188:drug therapy*; D010889:Piracetam / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000700:Analgesics; D000077287:Levetiracetam; D010889:Piracetam