Vitamin D status and hyperparathyroisism in postmenopausal osteoporotic patients in Cipto Mangunkusumo hospital Jakarta.
OBJECTIVE
to determine the profile of vitamin D and parathyroid hormone (PTH) and the proportion of vitamin D inadequacy in a population of postmenopausal osteoporotic patients from a rheumatologic outpatient clinic.


METHODS
a cross sectional study was conducted between October and December 2006 in the Rheumatology Clinic, Cipto Mangunkusumo Hospital with osteoporosis confirmed by bone mineral densitometry (T score less than -2.5 at the lumbar spine or hip). Patients were excluded if there was a history of oral glucocorticoid treatment within 30 days, vitamin D supplementation, and have renal and/or liver function impairments. Forty-two postmenopausal osteoporotic patients aged 51-77 years old who had been postmenopausal for 5-28 years were included in this study. Vitamin D inadequacy was defined as the plasma levels of 25(OH)D less than 50 nmol/L whereas hyperparathyroidism was defined as the PTH level more than 69 pg/dL.


RESULTS
vitamin D inadequacy was found in 61.9% of patients and 34.6% of them or 23.8% of total patients were also having high PTH level. There was an inverse correlation between 25(OH)D with PTH levels and positive correlation between duration of menopause and PTH level. Vitamin D inadequacy is common (61.9%) in postmenopausal osteoporotic patients who visited Rheumatology outpatient clinic of Cipto Mangunkusumo Hospital Jakarta.


CONCLUSIONS
the low concentration of 25(OH)D was correlated with PTH level and duration of menopause. This finding should be confirmed in a larger epidemiological study, either hospital-or community-based to assess vitamin D status among postmenopausal women in Indonesia.
Department of Internal Medicine, Faculty of Medicine-dr. Cipto Mangunkusumo Hospital, Jl. Diponegoro no. 71 Jakarta.
Sumariyono
S
Sarmidi
Bambang
B
Setiyohadi
Suryo Anggoro
SA
KW
D000368:Aged; D002118:Calcium / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood* / Q000150:complications; D007214:Indonesia / Q000453:epidemiology; D008875:Middle Aged; D009752:Nutritional Status; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D010281:Parathyroid Hormone / Q000097:blood*; D012307:Risk Factors; D014807:Vitamin D / Q000097:blood*
D010281:Parathyroid Hormone; D014807:Vitamin D; D002118:Calcium