Biaryl synthesis via decarboxylative Pd-catalyzed reactions of arenecarboxylic acids and diaryliodonium triflates.
A novel simple and efficient synthesis of biaryls via a Pd-catalyzed decarboxylative cross-coupling reaction of arenecarboxylic acids and diaryliodonium triflates is described. The PdCl2/DPEphos catalytic system in the presence of Ag2CO3 in DMSO was found to be the most efficient. Various biaryls, including sterically hindered biaryls, were synthesized with yields ranging from 37 to 85%.
Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, Laboratoire de Chimie Organique et Bioorganique, UMR-CNRS, Mulhouse cedex, France. jean-michel.becht@uha.fr
Jean-Michel
JM
Becht
Claude
C
Le Drian
D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents; D008698:Mesylates / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D002264:Carboxylic Acids; D007202:Indicators and Reagents; D008698:Mesylates; D010165:Palladium