Synovial sarcoma of the neck in a child: a multidisciplinary approach.
Synovial sarcoma (SS) is the most common nonrhabdomyosarcomatous soft tissue sarcoma in childhood, but the head-neck site accounts for less than 5% of cases. The authors report a 10-year-old boy with SYT-SSX1 positive left parapharyngeal SS, resistant to front-line VAIA chemotherapy, who obtained a good partial response by salvage regimen (I(3)VE + CEV + I(3)VE) and local radiotherapy, so a complete surgical resection could be performed. The complete remission was subsequently consolidated by ablative high-dose chemotherapy, followed by autologous stem cell reinfusion. The child remains in complete remission at 36 months after completion of treatment.
Pediatric Hematology Oncology, Ospedale dei Bambini "G. Di Cristina", Palermo, Italy.
Piero
P
Farruggia
Paolo
P
D'Angelo
Manlio
M
Lo Cascio
Luigi
L
Solazzo
Paolo
P
Montemaggi
Vincenzo
V
Novara
Rita
R
Alaggio
Angelo
A
Rosolen
Desiree
D
Caselli
Maurizio
M
Arico
D002648:Child; D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008297:Male; D012074:Remission Induction / Q000379:methods; D016879:Salvage Therapy / Q000379:methods; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000628:therapy