Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells.
Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC(50) of 30 microm (9.5 microg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.
Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720-3112, USA.
Teruhiko
T
Nitoda
Takahiko
T
Isobe
Isao
I
Kubo
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D047309:Flavones / Q000737:chemistry / Q000494:pharmacology; D044948:Flavonols / Q000737:chemistry / Q000494:pharmacology*; D005562:Formazans / Q000378:metabolism; D020128:Inhibitory Concentration 50; D037602:Isodon / Q000737:chemistry*; D008543:Melanins / Q000378:metabolism; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology; D012431:Rutin / Q000737:chemistry / Q000494:pharmacology; D013778:Tetrazolium Salts / Q000378:metabolism
D047309:Flavones; D044948:Flavonols; D005562:Formazans; D008543:Melanins; D010936:Plant Extracts; D013778:Tetrazolium Salts; C510777:pedalitin; C079782:MTT formazan; D012431:Rutin; D011794:Quercetin