RadC, a misleading name?
The pfam04002 annotation describes RadC as a bacterial DNA repair protein. Although the radC gene is expressed specifically during competence for genetic transformation in Streptococcus pneumoniae, we report that radC mutants exhibit normal uptake and processing of transforming DNA. They also display normal sensitivity to DNA-damaging agents, providing no support for the rad epithet.
Attaiech
Laetitia
L
Laboratoire de Microbiologie et Génétique Moléculaires, UMR 5100, CNRS, Université Paul Sabatier, 118 Route de Narbonne, 31062 Toulouse Cedex 09, France.
Granadel
Chantal
C
Claverys
Jean-Pierre
JP
Martin
Bernard
B
D001426:Bacterial Proteins / Q000235:genetics*; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics*; D017353:Gene Deletion; D023061:Gene Order; D005798:Genes, Bacterial; D013296:Streptococcus pneumoniae / Q000235:genetics* / Q000502:physiology; D009626:Terminology as Topic; D014169:Transformation, Bacterial
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins