Polyethyleneimine modified biocompatible poly(N-isopropylacrylamide)-based nanogels for drug delivery.
A series of biocompatible and stimuli-sensitive poly(N-isopropylacrylamide-co-propyl acrylic acid) (P(NIPAAm-co-PAAc)) nanogels were synthesized by emulsion polymerization. In addition, polyethyleneimine (PEI) was further grafted to modify the PNIPAAm-based nanogels. The P(NIPAAm-co-PAAc)-g-PEI nanogels exhibited good thermosensitivity as well as pH sensitivity. Transmission electron microscopy (TEM) showed that the P(NIPAAm-co-PAAc)-g-PEI and P(NIPAAm-co-PAAc) nanogels displayed well dispersed spherical morphology. The mean sizes of the nanogels measured by dynamic light scattering (DLS) were from 100 nm to 500 nm at different temperatures. The cytotoxicity study indicated P(NIPAAm-co-PAAc) nanogels exhibited a better biocompatibility than both PNIPAAm nanogel and P(NIPAAm-co-PAAc)-g-PEI nanogel although all the three kinds of nanogels did not exhibit apparent cytotoxicity. The drug-loaded nanogels, especially the PEI-grafted nanogels, showed temperature-trigged controlled release behaviors, indicating the potential applications as an intelligent drug delivery system.
Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan 430072, China.
Chang-Yun
CY
Quan
Hua
H
Wei
Yun-Xia
YX
Sun
Si-Xue
SX
Cheng
Kun
K
Shen
Zhong-Wei
ZW
Gu
Xian-Zheng
XZ
Zhang
Ren-Xi
RX
Zhuo
D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins; D001672:Biocompatible Materials / Q000737:chemistry*; D004337:Drug Carriers; D005782:Gels; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D011094:Polyethyleneimine / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013696:Temperature
D000178:Acrylamides; D000180:Acrylic Resins; D001672:Biocompatible Materials; D004337:Drug Carriers; D005782:Gels; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D011094:Polyethyleneimine