[Relativity analysis of chronic hepatitis B virus genotype and clinical pathology].
OBJECTIVE
To explore the relationship between chronic hepatitis B virus genotypes and clinical pathology.


METHODS
HBV genotype was determined in 92 cases with chronic hepatitis B patients and the relationship between HBV genotypes and clinical, serological and histological data of the patients was analyzed.


RESULTS
Sixteen cases were infected with HBV genotype B (17.4%), 71 with genotype C (77.2%), 3 with HBV classified as genotype B+C (3.2%) and in 2 (2.2%) cases HBV genotype was not confirmed. ALT level and HBV DNA load log value were (82.6+/-82) U/L, (84.7+/-71.5) U/L and (5.8+/-1.4), (5.9+/-1.5) respectively in genotypes B and C patients, in 8 cases of genotype C group liver cirrhosis was diagnosed, but no statistical significance was seen.


CONCLUSIONS
No significant differences in clinical, serological or histological data were detected between genotypes B and C patients.
The Liver Failure Therapy and Research Centre, No. 302 Hospital of the People's Liberation Army, Beijing, China.
Wei-ping
WP
He
Jin-hua
JH
Hu
Hui-fen
HF
Wang
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D005260:Female; D005838:Genotype; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000097:blood / Q000473:pathology* / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D004279:DNA, Viral; D006513:Hepatitis B e Antigens