[Clinical characteristics and laboratory assay of adult Japanese encephalitis patients in an outbreak in Yuncheng, Shanxi Province, 2006].
OBJECTIVE
To study the clinical and laboratory characteristics of adult Japanese encephalitis (JE) patients in a JE outbreak in Yuncheng, Shanxi Province in 2006.


METHODS
All the clinical data from the Second People's Hospital in Yuncheng city were analyzed, part of patients' sera and cerebrospinal fluid were tested by serology and RT-PCR.


RESULTS
The majority of patients were middle-aged and elderly, 77.8% (35/45) of the total cases were more than 40 years old. Severe and fulminating type cases accounted for 60.0% (27/45). Most patients had underlying diseases. IgM antibody to JE virus (JEV) in serum was positive in each of the 45 patients analyzed and 4-fold or greater rise in sera neutralization antibody titer were found in convalescent serum. JEV nucleic acid was positive in part of cerebrospinal fluid specimens.


CONCLUSIONS
Viral encephalitis emerged in Yuncheng city, Shanxi Province was Japanese encephalitis B, and most of the cases belonged to elderly group.
Zhang
Ding-lin
DL
The Second People's Hospital of Yuncheng City, Shanxi Province, Taiyuan, China.
Ma
Lu-bao
LB
Fu
Shi-hong
SH
Wang
Li-hua
LH
Wang
Huan-yu
HY
Zhang
Min
M
Wei
Zhi-gan
ZG
Li
Guo-gang
GG
Cui
Xiao-feng
XF
Lei
Hong-ge
HG
Sun
Xiao-hong
XH
Lv
Xin-jun
XJ
Li
Ming-hua
MH
Liang
Guo-dong
GD
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D004664:Encephalitis Virus, Japanese / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D004672:Encephalitis, Japanese / Q000097:blood / Q000134:cerebrospinal fluid / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055815:Young Adult
D000914:Antibodies, Viral; D007075:Immunoglobulin M; D012367:RNA, Viral