White matter abnormalities in children with idiopathic developmental delay.
BACKGROUND
The underlying cause of developmental delay (DD) often remains unclear despite extensive clinical examination and investigations. Interference in normal development of the brain may result in DD.


OBJECTIVE
To identify the prevalence of abnormalities on magnetic resonance (MR) imaging in idiopathic developmental delay.


METHODS
Of the 124 children referred for MR imaging with DD, 34 were excluded due to known history of progressive neurodevelopmental disorders, birth asphyxia, congenital CNS infections, metabolic disorder, chromosomal anomalies, and severe epileptic syndromes. The following structures were systematically reviewed: ventricles, corpus callosum, gray and white matter, limbic system, basal ganglia, brainstem, and cerebellum.


RESULTS
Ten out of 90 (11%) were referred with DD only, whilst 80/90 (89%) were referred with DD and additional clinical findings, such as seizures, neurological deficit, and abnormal head size. Of the 90 patients, 14 (16%) had normal MR and 76 (84%) had abnormal MR findings. Abnormal ventricles were seen in 43/90 (48%); abnormal corpus callosum was identified in 40/90 (44%). Other MR findings included abnormalities in the white matter (23/90, 26%), hippocampi (5/90, 6%), cerebellum (5/90, 6%), and brainstem (4/90, 4%).


CONCLUSIONS
Abnormalities of the ventricles and corpus callosum were identified in a large proportion of patients with idiopathic DD, indicative of changes in the white matter. Further studies using quantitative methods and diffusion tensor imaging are required to evaluate the white matter in these children.
Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada. elysa.widjaja@sickkids.ca
E
E
Widjaja
D
D
Nilsson
S
S
Blaser
C
C
Raybaud
D000293:Adolescent; D017677:Age Distribution; D061085:Agenesis of Corpus Callosum; D001921:Brain / Q000002:abnormalities / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D002552:Cerebral Ventricles / Q000002:abnormalities / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000473:pathology; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D015588:Observer Variation; D012189:Retrospective Studies; D012307:Risk Factors