Protective effects of a PPARgamma agonist pioglitazone on anti-oxidative system in testis of diabetic rabbits.
In the present study, modulation of oxidative stress by pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, was examined in testis of alloxan-induced diabetic rabbits. In diabetic animals, an increase in the activity of anti-oxidative enzymes: superoxide dismutase (Cu,Zn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GSSG-R), and in the level of glutathione (GSH) but a decrease in the level of ascorbic acid (AA) were observed. These effects were accompanied by a significant increase in testicular lipid and protein oxidation. Pioglitazone affected the activity of Cu,Zn-SOD, normalized the activity of CAT, the level of AA as well as the levels of LPO and PCG without having any significant effect on blood glucose level.
Department of Medicinal Chemistry, Medical University of Lublin, Poland. anna.gumieniczek@am.lublin.pl
A
A
Gumieniczek
H
H
Hopkała
A
A
Zabek
D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D047495:PPAR gamma / Q000819:agonists*; D000077205:Pioglitazone; D011817:Rabbits; D013737:Testis / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D045162:Thiazolidinediones / Q000494:pharmacology*
D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D047495:PPAR gamma; D045162:Thiazolidinediones; D005978:Glutathione; D001205:Ascorbic Acid; D000077205:Pioglitazone