Optical coherence tomography of the newborn airway.
OBJECTIVE
Acquired subglottic stenosis in a newborn is often associated with prolonged endotracheal intubation. This condition is generally diagnosed during operative endoscopy after airway injury has occurred. Unfortunately, endoscopy is unable to characterize the submucosal changes observed in such airway injuries. Other modalities, such as magnetic resonance imaging, computed tomography, and ultrasound, do not possess the necessary level of resolution to differentiate scar, neocartilage, and edema. Optical coherence tomography (OCT) is an imaging modality that produces high-resolution, cross-sectional images of living tissue (8 to 20 microm). We examined the ability of this noninvasive technique to characterize the newborn airway in a prospective clinical trial.


METHODS
Twelve newborn patients who required ventilatory support underwent OCT airway imaging. Comparative analysis of intubated and non-intubated states was performed.


RESULTS
Imaging of the supraglottis, glottis, subglottis, and trachea was performed in 12 patients, revealing unique tissue characteristics as related to turbidity, signal backscattering, and architecture. Multiple structures were identified, including the vocal folds, cricoid cartilage, tracheal rings, ducts, glands, and vessels.


CONCLUSIONS
Optical coherence tomography clearly identifies in vivo tissue layers and regional architecture while offering detailed information concerning tissue microstructures. The diagnostic potential of this technology makes OCT a promising modality in the study and surveillance of the neonatal airway.
Ridgway
James M
JM
Department of Otolaryngology-Head and Neck Surgery, University of California-Irvine, Irvine, California, USA.
Su
Jianping
J
Wright
Ryan
R
Guo
Shuguang
S
Kim
David C
DC
Barretto
Roberto
R
Ahuja
Gurpreet
G
Sepehr
Ali
A
Perez
Jorge
J
Sills
Jack H
JH
Chen
Zhongping
Z
Wong
Brian J F
BJ
D003937:Diagnosis, Differential; D004867:Equipment Design; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007828:Laryngoscopy / Q000379:methods; D007829:Laryngostenosis / Q000175:diagnosis*; D007830:Larynx / Q000473:pathology*; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000295:instrumentation*