Tooth abnormalities and soft tissue changes in patients with velocardiofacial syndrome.
OBJECTIVE
The objective of this study was to investigate the prevalence of tooth abnormalities and soft tissue changes in patients with velocardiofacial syndrome.


METHODS
Twenty-six patients with velocardiofacial syndrome were examined to investigate the presence of tooth abnormalities and soft tissue alterations. The occurrence of tooth agenesis and supernumerary teeth was compared to patients without morphofunctional alterations, matched for gender and age.


RESULTS
Of all patients, 76.92% exhibited at least one tooth abnormality, with predominance of hypoplastic alterations, especially represented by hypodevelopment of the lingual cusp of mandibular first premolars and enamel opacities. The occurrence of tooth agenesis and supernumerary teeth was similar in both study and control groups.


CONCLUSIONS
the present results suggest an association between hypodevelopment of the lingual cusp of mandibular first premolars and enamel opacities, yet these findings still require corroboration. Future studies should further investigate these aspects in larger samples compared to control groups, as well as employing molecular genetics techniques.
da Silva Dalben
Gisele
G
Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo, Bauru, Brazil. gsdalben@usp.br
Richieri-Costa
Antonio
A
de Assis Taveira
Luís Antônio
LA
D000293:Adolescent; D000328:Adult; D000848:Anodontia / Q000209:etiology; D001641:Bicuspid / Q000002:abnormalities; D016022:Case-Control Studies; D002648:Child; D002972:Cleft Palate / Q000209:etiology; D003743:Dental Enamel / Q000002:abnormalities; D004062:DiGeorge Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009056:Mouth Abnormalities / Q000209:etiology*; D021362:Palate, Hard / Q000002:abnormalities; D010160:Palate, Soft / Q000002:abnormalities; D014059:Tongue / Q000002:abnormalities; D014071:Tooth Abnormalities / Q000209:etiology*; D019228:Tooth Crown / Q000002:abnormalities; D014096:Tooth, Supernumerary / Q000209:etiology