Gold nanoparticles in delivery applications.
Gold nanoparticles (AuNPs) provide non-toxic carriers for drug and gene delivery applications. With these systems, the gold core imparts stability to the assembly, while the monolayer allows tuning of surface properties such as charge and hydrophobicity. An additional attractive feature of AuNPs is their interaction with thiols, providing an effective and selective means of controlled intracellular release.
Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA, 01003, USA.
Partha
P
Ghosh
Gang
G
Han
Mrinmoy
M
De
Chae Kyu
CK
Kim
Vincent M
VM
Rotello
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D018014:Gene Transfer Techniques; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013696:Temperature
D013438:Sulfhydryl Compounds; D006046:Gold