Neuroophthalmological side effects following intrathecal administration of liposomal cytarabine for central nervous system prophylaxis in three adolescents with acute myeloid leukaemia.
Three adolescents with central nervous system (CNS) negative acute myeloid leukaemia (AML) refused cranial irradiation for CNS prophylaxis. Instead, these patients received four doses of 50 mg of intrathecal (IT) liposomal cytarabine on day 1, 15, 43 and 71 of maintenance therapy. Corticosteroids were given to prevent chemical arachnoiditis. All patients developed bilateral papilloedema after the third or fourth dose of liposomal cytarabine, local side effects were observed in two patients. Under prolonged dexamethasone therapy, side effects resolved completely. As reversible neuroophthalmological side effects caused by intrathecal liposomal cytarabine can also be observed under low-dose maintenance therapy in patients with CNS negative AML, it should be used with caution in children and adolescents.
Division of Paediatric Haematology and Oncology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 30, A-8036 Graz, Austria. constanze.sommer@meduni-graz.at
Constanze
C
Sommer
Herwig
H
Lackner
Martin
M
Benesch
Petra
P
Sovinz
Wolfgang
W
Schwinger
Andrea
A
Moser
Jutta
J
Bergloeff
Anna
A
Gruber
Christian
C
Urban
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects*; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007278:Injections, Spinal / Q000009:adverse effects; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008081:Liposomes; D008297:Male; D010211:Papilledema / Q000139:chemically induced* / Q000188:drug therapy; D012074:Remission Induction
D000305:Adrenal Cortex Hormones; D000964:Antimetabolites, Antineoplastic; D008081:Liposomes; D003561:Cytarabine; D003907:Dexamethasone