Desonide: a review of formulations, efficacy and safety.
BACKGROUND
Desonide is a low-potency topical corticosteroid that has been used for decades in the treatment of steroid-responsive dermatoses. The favorable safety profile of this topical agent makes it ideal for patients of all ages.


OBJECTIVE
This article provides a review of desonide's history, pharmacodynamic properties, vehicle technology, efficacy and safety.


METHODS
Randomized controlled trials, as well as open-label and non-comparative studies, case series and reports, experimental models, and data from the Galderma pharmacovigiliance program were reviewed in order to address the clinical efficacy and safety of desonide.


CONCLUSIONS
Clinical efficacy and safety have been proven in multiple clinical trials. In addition to cream, lotion and ointment formulations, the recently developed hydrogel and foam preparations have increased desonide's versatility and patient tolerability.
Kahanek
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Department of Dermatology, University of Texas-Houston Medical School, 6431 Fannin, Houston, TX 77003, USA.
Gelbard
Cg
C
Hebert
Aa
A
D002626:Chemistry, Pharmaceutical; D003898:Desonide / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004304:Dosage Forms; D006801:Humans
D004304:Dosage Forms; D003898:Desonide