Autophagy-modulating aminosteroids isolated from the sponge Cliona celata.
Clionamines A-D (1- 4), new aminosteroids that modulate autophagy, have been isolated from South African specimens of the sponge Cliona celata. Clionamine D (4) has an unprecedented spiro bislactone side chain.
Department of Chemistry and Earth & Ocean Sciences, University of British Columbia, Vancouver, BC, Canada.
Robert A
RA
Keyzers
Julie
J
Daoust
Michael T
MT
Davies-Coleman
Rob
R
Van Soest
Aruna
A
Balgi
Elizabeth
E
Donohue
Michel
M
Roberge
Raymond J
RJ
Andersen
D000818:Animals; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry
D013141:Spiro Compounds; D013256:Steroids; C530919:clionamine D