Changes in levels of essential elements in suckling rats exposed to zinc and mercury.
The effect of mercury and its interaction with zinc on the content of essential metals in tissues from neonate rats was investigated. Three-day-old Wistar rats were treated with saline or 27 mg kg(-1)d(-1) ZnCl2 (s.c.) for five consecutive days. From the 8th to the 12th day of life, the rats received one daily dose of saline or 5.0 mg kg(-1) HgCl2 (s.c). Twenty-four hours after the last injection liver, kidneys and blood were collected for metal quantification. The HgCl(2) exposure induced alterations on metal levels, such as increase of Fe, Hg and Zn in liver, decrease of Fe and Mg and increase of Cu and Hg contents in kidneys. The Hg exposure also increased Hg levels in the blood. The treatment with ZnCl2, administered previously to HgCl2, partially prevented the increase of Fe in the liver, and not only prevented the decrease of renal Mg but also increased it to levels higher than those found in control group. The Zn-Hg rats also presented higher renal Cu levels, and showed partially lower blood and hepatic Hg levels and higher renal Hg levels. The pre-administration of Zn caused no severe alterations in levels of essential metals (Cu, Fe, Mg and Mn). In short, Zn appears to be an alternative treatment of Hg poisoning in young animals in comparison to chelating drugs since these have low metal selectivity.
Programa de Pós-Graduação em Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitário, Camobi, Santa Maria, RS, Brazil. ncpeixoto@yahoo.com.br
N C
NC
Peixoto
L C
LC
Rocha
D P
DP
Moraes
M J
MJ
Bebianno
V L
VL
Dressler
E M M
EM
Flores
M E
ME
Pereira
D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism / Q000494:pharmacology*; D003300:Copper / Q000097:blood / Q000378:metabolism; D004602:Elements; D005260:Female; D007202:Indicators and Reagents; D007501:Iron / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008274:Magnesium / Q000097:blood / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000097:blood / Q000378:metabolism; D008627:Mercuric Chloride / Q000378:metabolism / Q000633:toxicity*; D008628:Mercury / Q000097:blood / Q000378:metabolism; D051381:Rats; D017967:Zinc Compounds / Q000378:metabolism / Q000494:pharmacology*
D002712:Chlorides; D004602:Elements; D007202:Indicators and Reagents; D017967:Zinc Compounds; D008345:Manganese; D008627:Mercuric Chloride; D003300:Copper; C016837:zinc chloride; D007501:Iron; D008628:Mercury; D008274:Magnesium