[Management of hepatitis B virus reactivation during chemotherapy or immunosuppressive therapy].
Reactivation of viral hepatitis B is a well-known complication in patients receiving chemotherapy or immunosuppressive therapy; its incidence reaches 50%. This reactivation is associated with a high rate of morbidity and mortality. Prophylactic treatment of viral reactivation with lamivudine resulted in lowering the incidence of this risk and improving prognosis in recent studies. Patients with hematological malignancies and other cancers require a precise assessment of their hepatitis B status and adequate management. There is not yet a consensus about the appropriateness of prophylactic treatment of occult hepatitis B infection or of pretreatment virologic assessment, especially measurement of viral DNA.
Service de Gastro-Entérologie, EPS Hédi Chaker, Sfax, Tunisie. ali_amouri@yahoo.fr
Ali
A
Amouri
Lassaad
L
Chtourou
Leila
L
Mnif
Nabi
N
Tahri
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006509:Hepatitis B / Q000139:chemically induced / Q000517:prevention & control; D017325:Hepatitis B Vaccines; D006515:Hepatitis B virus / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D019259:Lamivudine / Q000627:therapeutic use; D012307:Risk Factors; D014775:Virus Activation / Q000187:drug effects*
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D017325:Hepatitis B Vaccines; D007166:Immunosuppressive Agents; D019259:Lamivudine