Polycystic ovary syndrome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease.
OBJECTIVE
To determine the level of plasma soluble CD40 ligand (sCD40L) in patients with polycystic ovary syndrome (PCOS).


METHODS
Prospective study.


METHODS
Baskent University School of Medicine in Turkey.


METHODS
Thirty-one patients with PCOS and 31 non-PCOS (control) patients.


METHODS
Determination of plasma sCD40L and homocysteine levels.


METHODS
Plasma sCD40L, fasting glucose, fasting insulin, homeostatic model assessment insulin resistance index (HOMA-IR), LH, FSH, E(2), total T, DHEAS, total cholesterol, high- and low-density lipoprotein cholesterol, triglyceride, homocysteine, and high-sensitivity C-reactive protein (hsCRP).


RESULTS
The mean serum fasting insulin and HOMA-IR levels were significantly higher in the PCOS group. The mean serum homocysteine level was significantly higher in the PCOS group. Despite a trend for higher high-sensitivity C-reactive protein levels in the PCOS group, the difference did not reach statistical significance. The mean plasma sCD40L level in the PCOS group was significantly higher than that in the control group (5.14 +/- 3.65 ng/mL vs. 3.45 +/- 2.64 ng/mL, respectively).


CONCLUSIONS
Polycystic ovary syndrome is associated with elevated levels of sCD40L and homocysteine.
Department of Obstetrics and Gynecology, Baskent University School of Medicine, Ankara, Turkey. mesutoktem@hotmail.com
Mesut
M
Oktem
Emel Ebru
EE
Ozcimen
Ayla
A
Uckuyu
Ibrahim
I
Esinler
Baris
B
Pamuk
Nilufer
N
Bayraktar
Sevsen
S
Kulaksizoglu
Hulusi B
HB
Zeyneloglu
D000328:Adult; D000568:Amenorrhea / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D023201:CD40 Ligand / Q000097:blood*; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D009839:Oligomenorrhea / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000473:pathology; D012016:Reference Values; D049629:Waist-Hip Ratio; D055815:Young Adult
D015415:Biomarkers; D007328:Insulin; D006710:Homocysteine; D023201:CD40 Ligand