Enzymatic degradation and transport of endothiopeptides into Escherichia coli K12 mutant strains.
Transport of three synthesized endothiopeptides: AlaPsi[CSNH]Ala, AlaPsi[CSNH]Leu, and AlaPsi[CSNH]Phe, into Escherichia coli K12 mutant strains and enzymatic degradation studies were carried out. These compounds, well transported by permeases, but significantly more resistant to enzymatic cleavage than the corresponding natural peptides, seem to be useful as enzyme inhibitor carriers.
Nowak-Jary
Julia
J
Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk, Poland.
Andruszkiewicz
Ryszard
R
Payne
John W
JW
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000493:pharmacokinetics; D048168:Escherichia coli K12 / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism; D010455:Peptides / Q000378:metabolism* / Q000494:pharmacology*; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D026901:Membrane Transport Proteins; D010455:Peptides; D011506:Proteins