Efficiency of the cyclic batch antibiotic fermentation.
For a simple mathematical model of microbial product formation, the productivities of stationary and nonstationary cultivation methods (chemostat and cyclic batch) are compared. Conditions of superiority of the cyclic batch cultivation are characterized. The model includes substrate inhibition of the product formation and the age-dependent loss of productivity of the culture.
Guthke
R
R
Central Institute of Microbiology and Experimental Therapy, Academy of Sciences of the German Democratic Republic, 6900 Jena, German Democratic Republic.
Knorre
W A
WA