Growth inhibition of struvite crystals in the presence of herbal extract Commiphora wightii.
Struvite is one of the components of urinary stone. Large number of people is suffering from urinary stones (calculi) problem all over the globe. These stones can grow rapidly forming "staghorn-calculi", which is more painful urological disorder. Therefore, it is of prime importance to study the growth and inhibition of Struvite crystals. This in vitro study has been carried out in the presence of herbal extract of Commiphora wightii by using single diffusion gel growth technique. Sodium metasilicate solution of specific gravity 1.05 and an aqueous solution of ammonium dihydrogen phosphate of 0.5 M concentration were mixed so that the pH value 7.0 could be set. After the gelation, equal amount of supernatant solutions comprising of pure 1.0 M magnesium acetate as well as the mixtures of magnesium acetate and the herbal extract solutions of 0.5 and 1% concentrations of C. wightii were gently poured on the set gels. From the study of growth and inhibition behavior of Struvite crystals, it was found that C. wightii inhibits the growth of the Struvite. This study incorporates multidisciplinary interests and may be used for formulating the strategy for prevention or dissolution of urinary stones.
Chauhan
C K
CK
Crystal Growth Laboratory, Department of Physics, Saurashtra University, Rajkot 360 005, Gujarat, India. ckc33@rediffmail.com
Joshi
M J
MJ
Vaidya
A D B
AD
D011232:Chemical Precipitation / Q000187:drug effects*; D029744:Commiphora / Q000737:chemistry; D003460:Crystallization; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation / Q000187:drug effects; D066298:In Vitro Techniques; D007669:Kidney Calculi / Q000737:chemistry / Q000517:prevention & control; D017616:Magnesium Compounds / Q000737:chemistry*; D010316:Particle Size; D010710:Phosphates / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D012995:Solubility / Q000187:drug effects; D000069877:Struvite; D014545:Urinary Calculi / Q000737:chemistry / Q000517:prevention & control
D017616:Magnesium Compounds; D010710:Phosphates; D010936:Plant Extracts; D000069877:Struvite