A case of catastrophic antiphospholipid syndrome in an adolescent girl with parvovirus B19 infection.
Antiphospholipid syndrome is an autoimmune disease characterized by recurrent thrombosis and the presence of antiphospholipid antibodies. Clinical presentations are dependent on the affected vessels and organs. The most common presentation of antiphospholipid syndrome is arterial or venous thrombosis. An unusual presentation of the disease is characterized by microvascular thrombosis with multiorgan involvement, which is termed catastrophic antiphospholipid syndrome. The diagnosis of catastrophic antiphospholipid syndrome can be difficult because of the heterogeneity of the different clinical forms. Clinical manifestations of catastrophic antiphospholipid syndrome are complex with multiple organ involvement, resulting in renal insufficiency, heart failure, acute respiratory distress syndrome, and liver involvement. Early diagnosis and aggressive therapies are essential in this condition because of the extremely high mortality rate. Herein, the case of a 14-year-old girl with catastrophic antiphospholipid syndrome that was previously misdiagnosed as a vasculitis related to parvovirus B19 infection is presented.
Department of Pediatric Nephrology, Istanbul University, Istanbul, Turkey. dr.canpolat@hotmail.com
Nur
N
Canpolat
Nilufer
N
Topal
Mahmut
M
Civilibal
Salim
S
Caliskan
Lale
L
Sever
Ozgur
O
Kasapcopur
Tahire
T
Baserer
Nil
N
Arisoy
D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D002388:Catastrophic Illness; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D009102:Multiple Organ Failure / Q000209:etiology / Q000628:therapy; D010322:Parvoviridae Infections / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D016732:Parvovirus B19, Human; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D014657:Vasculitis / Q000175:diagnosis
D000893:Anti-Inflammatory Agents; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D011239:Prednisolone; D008775:Methylprednisolone