Coronary artery disease patient's first degree relatives may be at higher risk for atherosclerosis.
Our aim was to investigate the relationship between the serologic status concerning Chlamydia pneumoniae (Cp), Helicobacter pylori (Hp), Cytomegalovirus (CMV) and high sensitive C-reactive protein (hsCRP) in coronary artery disease (CAD) patient's first degree relatives, which remain an unrevealed issue in literature. We studied 192 CAD patients (pts), 140 CAD-patient first degree relatives (CAD-R) and 192 controls with no evidence of obstructive CAD. Seropositivity for Cp IgG (71 vs 50, p=0.090), Hp IgA (98 vs 59, p=0.06), Hp IgG (77 vs 55, p=0.09), CMV IgG (62 vs 44, p=1.00), Ct IgG (7 vs 6, p=0.78) was not significantly higher in CAD-pts compared to CAD-R. However, seropositivity to Cp IgA (154 vs 96, p=0.020) and hsCRP (114 vs 65, p=0.014) were significantly higher in CAD-pts compared to CAD-R. Further differences between CAD-R and controls were significant for all seropositive groups and hsCRP. Therefore, this study adds to the strong evidence of association of Cp specific IgA and hsCRP with CAD and CAD-R is at higher risk for disease progression.
Jha
Hem Chandra
HC
Mittal
Aruna
A
D050197:Atherosclerosis / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D005190:Family; D006801:Humans; D012307:Risk Factors