Role of natural antibodies in immune homeostasis: IVIg perspective.
Intravenous immunoglobulin (IVIg) has increasingly been used for the treatment of autoimmune and systemic inflammatory diseases in addition to supportive therapy of immunodeficient patients. Although a considerable progress has been made in understanding the mechanisms by which IVIg exerts immunomodulatory functions in these diseases, they remain not fully elucidated. The mode of action of IVIg is complex, involving interference with activation of complement and the cytokine network, modulation of: idiotype network, expression of Fc receptors, and activation, differentiation and effector functions of T and B cells and of antigen-presenting cells such as dendritic cells. The therapeutic effects of IVIg most likely reflect the functions of natural antibodies in maintaining immune homeostasis in healthy individuals.
Centre de Recherche des Cordeliers, Equipe 16 - Immunopathology and Therapeutic Immunointervention, Université Pierre et Marie Curie - Paris 6, UMR S 872, Paris, F-75006, France.
Janakiraman
J
Vani
Sriramulu
S
Elluru
Vir-Singh
VS
Negi
Sébastien
S
Lacroix-Desmazes
Michel D
MD
Kazatchkine
Jagadeesh
J
Bayry
Jagadeesh
J
Bayary
Srini V
SV
Kaveri
D001323:Autoantibodies / Q000276:immunology; D001402:B-Lymphocytes / Q000187:drug effects; D003169:Complement Inactivator Proteins / Q000494:pharmacology; D016207:Cytokines / Q000096:biosynthesis; D003713:Dendritic Cells / Q000187:drug effects; D006706:Homeostasis; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D016756:Immunoglobulins, Intravenous / Q000276:immunology / Q000494:pharmacology* / Q000502:physiology; D011956:Receptors, Cell Surface / Q000276:immunology; D011961:Receptors, Fc / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects
D001323:Autoantibodies; D003169:Complement Inactivator Proteins; D016207:Cytokines; D007130:Immunoglobulin Idiotypes; D016756:Immunoglobulins, Intravenous; D011956:Receptors, Cell Surface; D011961:Receptors, Fc