Synthesis of bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates as antibacterial agents against VRSA.
Bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates were synthesized using solid phase synthesis technique. These compounds were screened for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) (11 strains) and vancomycin-resistant S. aureus (VRSA) (4 strains). Bis, tris and tetra(dihydrocaffeoyl)polyamine analogues showed antibacterial activity against VRSA which were better than the reference drugs, vancomycin. Tetra(dihydrocaffeoyl)polyamine conjugate exhibited the highest activity. These compounds showed no cytotoxicity against vero cells.
Yingyongnarongkul
Boon-ek
BE
Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkapi, Bangkok, 10240, Thailand. boonek@ru.ac.th
Apiratikul
Nuttapon
N
Aroonrerk
Nuntana
N
Suksamrarn
Apichart
A
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002109:Caffeic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D020128:Inhibitory Concentration 50; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013095:Spermidine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D020713:Vancomycin Resistance; D014709:Vero Cells
D000900:Anti-Bacterial Agents; D002109:Caffeic Acids; C000995:3,4-dihydroxyphenylpropionic acid; D013095:Spermidine