Turner mosaicism (45,X/46,XX) diagnosed in a young woman subsequent to low oocyte maturity and failed ICSI.
OBJECTIVE
To report a case of Turner mosaicism with low oocyte maturity during ICSI.


METHODS
Retrospective case report.


METHODS
Academic tertiary medical center.


METHODS
A 28-year-old patient with 7-year history of primary unexplained infertility.


METHODS
Four cycles of ICSI.


METHODS
Oocyte quality; fertilization, cleavage, and implantation rates; and live births during ICSI cycles; as well as patient karyotype were obtained.


RESULTS
Over four cycles of ICSI, 111 oocytes were harvested, a high follicular response, but 68% were immature (germinal vesicles or metaphase I). Additionally, seven embryos were transfered, but none implanted. Owing to this unusual response in a young healthy woman, maternal karyotype was performed, which demonstrated 17% Turner mosaicism.


CONCLUSIONS
This is, to our knowledge, the first reported case of excellent ovarian response but marked oocyte immaturity in a young woman with Turner mosaicism. The implications of sex chromosome aneuploidy on fertility and the significance of low oocyte maturity are discussed.
Moore
Andrew K
AK
Baystate Reproductive Medicine, Baystate Medical Center, Springfield, Massachusetts, USA. andrew.moore@bhs.org
Lynch
Kelly
K
Arny
Margaret J
MJ
Grow
Daniel R
DR
D000328:Adult; D041321:Chromosomes, Human, X; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D007621:Karyotyping; D009030:Mosaicism; D009865:Oocytes / Q000473:pathology*; D010062:Ovulation Induction; D020554:Sperm Injections, Intracytoplasmic; D017211:Treatment Failure; D014424:Turner Syndrome / Q000150:complications / Q000175:diagnosis* / Q000235:genetics