[Immunohistochemical study of endometrial stromal sarcoma and smooth-muscle tumors of the uterus].
OBJECTIVE
Positive and differential diagnoses of mesenchymal tumors of the uterus may be sometimes problematic. The purpose of this study was to evaluate the utility of a panel of antibodies in this diagnosis.


METHODS
The expression of AML, desmin, h-caldesmon and CD10 was studied in nine endometrial stromal sarcomas (SSE), two leiomyosarcomas (LMS) and 10 highly-cellular leiomyoma (HCL).


RESULTS
AML positivity was found in five SSE, in all HCL and in only one LMS. Desmin expression was found in two SSE, in all HCL and LMS. H-caldesmon was negative in all SSE, positive in all HCL and in one case of LMS. CD10 was expressed in two-third of SSE. However, neither HCL nor LMS was marqued.


CONCLUSIONS
CD10 is the most specific antibody of SSE. It seems to have the best value in the diagnosis of mesenchymal tumors in association with desmin and h-caldesmon, specific markers of smooth-muscle differentiation.
Service d'anatomie et de cytologie pathologiques, hôpital Charles-Nicolle, boulevard 9-Avril-1938, 1006 Tunis, Tunisie. farah_faten@yahoo.fr
F
F
Farah-Klibi
S
S
Ben Hamouda
S
S
Ben Romdhane
R
R
Sfar
A
A
Koubaa
S
S
Ben Jilani
R
R
Zermani
D000199:Actins / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D002148:Calmodulin-Binding Proteins / Q000032:analysis; D003893:Desmin / Q000032:analysis; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007889:Leiomyoma / Q000175:diagnosis; D007890:Leiomyosarcoma / Q000175:diagnosis; D015260:Neprilysin / Q000032:analysis; D012189:Retrospective Studies; D018203:Sarcoma, Endometrial Stromal / Q000737:chemistry / Q000175:diagnosis*; D014594:Uterine Neoplasms / Q000175:diagnosis
D000199:Actins; D014408:Biomarkers, Tumor; D002148:Calmodulin-Binding Proteins; D003893:Desmin; D015260:Neprilysin