Autoimmune oophoritis in the adolescent.
Autoimmune oophoritis presents in adolescents as a component of autoimmune polyendocrine syndrome type I or type II. Autoimmune oophoritis can be diagnosed in women with primary ovarian insufficiency in the presence of adrenal cortical or steroid cell antibodies, and/or antibodies to adrenal and ovarian steroidogenic enzymes. The ovaries are cystic macroscopically, with a lymphocytic infiltrate in the steroidogenic theca cells. The immune infiltrate results in low estradiol levels and a compensatory increase in FSH levels. Granulosa cells are spared, and inhibin A and B levels are normal to high. Treatment is aimed at symptom relief with further investigation needed to assess treatment options such as immunosuppression.
Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. cwelt@partners.org
Corrine K
CK
Welt
D000293:Adolescent; D001323:Autoantibodies; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007265:Inhibins / Q000097:blood; D009869:Oophoritis / Q000188:drug therapy / Q000276:immunology*; D010053:Ovary / Q000276:immunology / Q000473:pathology*; D016884:Polyendocrinopathies, Autoimmune / Q000188:drug therapy / Q000276:immunology*
D001323:Autoantibodies; D007166:Immunosuppressive Agents; C422362:inhibin A; C422364:inhibin B; D004958:Estradiol; D007265:Inhibins; D005640:Follicle Stimulating Hormone