The antioxidant response induced by Lonicera caerulaea berry extracts in animals bearing experimental solid tumors.
Lonicera caerulea is a species of bush native to the Kamchatka Peninsula (Russian Far East) whose berries have been extensively studied due to their potential high antioxidant activity. The aim of our work was to investigate the in vivo effects of the antioxidant action of Lonicera caerulea berry extracts on the dynamics of experimentally-induced tumors. Our data showed that aqueous Lonicera caerulaea extracts reduced the tumor volume when administered continuously during the tumor growth and development stages, but augmented the tumor growth when the administration of extracts started three weeks before tumor grafting. Prolonged administration of Lonicera caerulaea berry extracts induced the antioxidant defense mechanism in the tumor tissues, while surprisingly amplifying the peripheral oxidative stress.
Institute of Oncology Bucharest, 252 Fundeni, 022338, Bucharest, Romania.
Maria Iuliana
MI
Gruia
Eliza
E
Oprea
Ion
I
Gruia
Valentina
V
Negoita
Ileana Cornelia
IC
Farcasanu
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D049109:Cell Proliferation / Q000187:drug effects; D002570:Ceruloplasmin / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D031239:Lonicera / Q000378:metabolism*; D008297:Male; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000378:metabolism
D000975:Antioxidants; D010936:Plant Extracts; D013438:Sulfhydryl Compounds; D002570:Ceruloplasmin