[Local chemotherapy of malignant glioma: from syringe injections to nanotechnology].
Many arguments support the development of local therapies for malignant gliomas. Simple injections of antimitotic agents into the surgical cavity has been replaced by more sophisticated systems. Tissues can be infused with complex prolonged-release polymeric or lipidic systems with macroscopic, microscopic and now even nanometric particles. But, as for any drug, the developments of these new agents has been long and only very few reach the stage of the clinic trials.
Inserm U646, Angers, France.
S
S
Petit
E
E
Garcion
J-P
JP
Benoit
P
P
Menei
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D004343:Drug Implants; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D007267:Injections; D008845:Microinjections; D053758:Nanoparticles; D036103:Nanotechnology / Q000639:trends*; D013594:Syringes
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004343:Drug Implants