Delivery of small interfering RNA. A review and an example of application to a junction oncogene.
RNA interference strategies using small interfering RNA is one of the most important discoveries in biology in recent years. This technology alongside antisense oligonucleotides is very promising and our group has focused its work on the targeting of junction oncogenes with these molecules. We have taken, as first example, papillary thyroid carcinoma. But there is a great need in delivery methods for these molecules in the treatment of cancers. Indeed, many studies have shown that small interfering RNA and antisense oligonucleotides are made efficient by various innovative delivery methods and, under these conditions, offer a powerful new therapeutic tool in cancer treatment.
Ramon
Anne-Laure
AL
CNRS UMR 8121, Université Paris-Sud, Institut Gustave Roussy Villejuif, France.
Bertrand
Jean-Rémi
JR
Malvy
Claude
C
D000818:Animals; D002291:Carcinoma, Papillary / Q000188:drug therapy* / Q000235:genetics; D016503:Drug Delivery Systems; D006801:Humans; D020320:Oligoribonucleotides, Antisense / Q000008:administration & dosage*; D009857:Oncogenes; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics*; D034741:RNA, Small Interfering / Q000008:administration & dosage*; D013964:Thyroid Neoplasms / Q000188:drug therapy* / Q000235:genetics
D020320:Oligoribonucleotides, Antisense; D034741:RNA, Small Interfering; D051096:Proto-Oncogene Proteins c-ret