Modelling drug elution from stents: effects of reversible binding in the vascular wall and degradable polymeric matrix.
Today the most popular approach for the prevention of the restenosis consists in the use of the drug eluting stents. The stent acts as a source of drug, from a coating or from a reservoir, which is transported into and through the artery wall. In this study, the behaviour of a model of a hydrophilic drug (heparin) released from a coronary stent into the arterial wall is investigated. The presence of the specific binding site action is modelled using a reversible chemical reaction that explains the prolonged presence of drug in the vascular tissue. An axi-symmetric model of a single stent strut is considered. First an advection-diffusion problem is solved using the finite element method. Then a simplified model with diffusion only in the arterial wall is compared with: (i) a model including the presence of reversible binding sites in the vascular wall and (ii) a model featuring a drug reservoir made of a degradable polymeric matrix. The results show that the inclusion of a reversible binding for the drug leads to delayed release curves and that the polymer erosion affects the drug release showing a quicker elution of the drug from the stent.
Department of Structural Engineering, LaBS, Laboratory of Biological Structure Mechanics, Politecnico di Milano, Milan, Italy.
A
A
Borghi
E
E
Foa
R
R
Balossino
F
F
Migliavacca
G
G
Dubini
D000925:Anticoagulants / Q000008:administration & dosage; D001807:Blood Vessel Prosthesis; D003198:Computer Simulation; D023903:Coronary Restenosis / Q000503:physiopathology* / Q000517:prevention & control*; D004343:Drug Implants / Q000008:administration & dosage* / Q000737:chemistry; D019544:Equipment Failure Analysis; D006493:Heparin / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D008955:Models, Cardiovascular; D015607:Stents
D000925:Anticoagulants; D004343:Drug Implants; D006493:Heparin