Current topics in prevention of human T-cell leukemia virus type i infection: NF-kappa B inhibitors and APOBEC3.
Human T-cell leukemia virus type I (HTLV-I) is the first human retrovirus and causes adult T-cell leukemia/lymphoma (ATL). Constitutive activation of nuclear factor-kappa B (NF-kappa B) in the leukemic cells is essential for their growth and survival. Thus, NF-kappa B inhibitors have been attracting attention as a potential strategy to treat ATL. Recently, the field of retrovirus research has been stimulated by the discovery of an innate host defense factor, APOBEC3, against the retroviruses. HTLV-I is relatively resistant to the antiviral effects of APOBEC3. To clarify the resistance of HTLV-I against APOBEC3 might contribute to the design of effective therapeutic approaches.
Division of Microbiology and Genetics, Center for Animal Resources and Development, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan. ohsugi@gpo.kumamoto-u.ac.jp
Takeo
T
Ohsugi
Atsushi
A
Koito
D000071478:APOBEC Deaminases; D000328:Adult; D000818:Animals; D003564:Cytidine Deaminase; D043525:Cytosine Deaminase / Q000276:immunology / Q000494:pharmacology*; D015490:HTLV-I Infections / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D020672:I-kappa B Proteins / Q000276:immunology / Q000494:pharmacology*; D007113:Immunity, Innate; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000276:immunology; D018894:Reverse Transcriptase Inhibitors / Q000276:immunology / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D020672:I-kappa B Proteins; D016328:NF-kappa B; C000606204:NFKBIA protein, human; D018894:Reverse Transcriptase Inhibitors; D000072000:NF-KappaB Inhibitor alpha; D043525:Cytosine Deaminase; D000071478:APOBEC Deaminases; C502889:APOBEC3 proteins, human; D003564:Cytidine Deaminase