Invasive and noninvasive correlations of B-type natriuretic peptide in patients with heart failure due to Chagas cardiomyopathy.
Heart failure due to Chagas cardiomyopathy (HFCC) differs from failure with other etiologies because of the occurrence of intense inflammatory infiltrate and right ventricle compromise. This article investigates correlations of B-type natriuretic peptide (BNP) levels with parameters of severity in HFCC. Twenty-eight patients and 8 normal controls underwent heart catheterization and clinical and laboratory analyses. BNP levels were higher in patients with HFCC (P<.0001) and correlated with New York Heart Association (NYHA) class; right atrial pressure; wedge pressure; cardiac output; levels of serum sodium, hemoglobin, urea, and tumor necrosis factor-alpha; and ejection fraction. Interferon-gamma and transforming growth factor-beta did not correlate with BNP level. The authors conclude that BNP levels are elevated in patients experiencing HFCC, irrespective of NYHA class, and that the occurrence of HFCC correlates with severity of disease.
Vilas-Boas
Fábio
F
Heart Failure Clinics and Academic Research Department of Santa Izabel Hospital, Salvador, BA, Brazil. fabiovboas@cardiol.br
Feitosa
Gilson Soares
GS
Soares
Milena B P
MB
Pinho-Filho
Joel Alves
JA
Nascimento
Thais
T
Barojas
Marcos M
MM
Andrade
Marcus V S
MV
Ribeiro-Dos-Santos
Ricardo
R
Bocchi
Edimar
E
D006328:Cardiac Catheterization; D016022:Case-Control Studies; D002598:Chagas Cardiomyopathy / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D003971:Diastole; D017079:Exercise Tolerance; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013599:Systole
D020097:Natriuretic Peptide, Brain