The bioinorganic chemistry and associated immunology of chronic beryllium disease.
Chronic beryllium disease (CBD) is a debilitating, incurable, and often fatal disease that is caused by the inhalation of beryllium particulates. The growing use of beryllium in the modern world, in products ranging from computers to dental prosthetics (390 tons of beryllium in the US in the year 2000) necessitates a molecular based understanding of the disease in order to prevent and cure CBD. We have investigated the molecular basis of CBD at Los Alamos National Laboratory during the past six years, employing a multidisciplinary approach of bioinorganic chemistry and immunology. The results of this work, including speciation, inhalation and dissolution, and immunology will be discussed.
Scott
Brian L
BL
Materials Physics and Applications Division, Los Alamos National Laboratory, Los Alamos, NM 87544, USA. bscott@lanl.gov
McCleskey
T Mark
TM
Chaudhary
Anu
A
Hong-Geller
Elizabeth
E
Gnanakaran
S
S
D001608:Beryllium / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism*; D055598:Chemical Phenomena; D015393:Chemistry, Bioinorganic; D002908:Chronic Disease; D016207:Cytokines / Q000378:metabolism; D006682:HLA-DP Antigens / Q000737:chemistry / Q000276:immunology; D006801:Humans; D011485:Protein Binding
D016207:Cytokines; D006682:HLA-DP Antigens; D001608:Beryllium