Estimating a multivariate familial correlation using joint models for canonical correlations: application to memory score analysis from familial Hispanic Alzheimer's disease study.
Analysis of multiple traits can provide additional information beyond analysis of a single trait, allowing better understanding of the underlying genetic mechanism of a common disease. To accommodate multiple traits in familial correlation analysis adjusting for confounders, we develop a regression model for canonical correlation parameters and propose joint modeling along with mean and scale parameters. The proposed method is more powerful than the regression method modeling pairwise correlations because it captures familial aggregation manifested in multiple traits through maximum canonical correlation.
Lee
Hye-Seung
HS
Pediatrics Epidemiology Center, University of South Florida, Tampa, Florida 33612, USA. leeh@epi.usf.edu
Cho Paik
Myunghee
M
Lee
Joseph H
JH
D000544:Alzheimer Disease / Q000175:diagnosis / Q000208:ethnology* / Q000235:genetics*; D003198:Computer Simulation; D005190:Family; D020022:Genetic Predisposition to Disease / Q000208:ethnology* / Q000235:genetics*; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D008569:Memory Disorders / Q000175:diagnosis / Q000208:ethnology* / Q000235:genetics*; D008957:Models, Genetic; D009483:Neuropsychological Tests; D013223:Statistics as Topic