Small animal PET in preclinical studies: opportunities and challenges.
The process of drug and molecular imaging development is strongly influenced by the revolution of non-invasive imaging techniques. Small animal positron emission tomography (PET) has the potential to accelerate and streamline drug and molecular imaging discovery and development by preselection of suitable candidate molecules. Due to its significantly improved spatial resolution and its quantitative nature, compared to other techniques small animal PET can be employed to bridge the in vitro, through to preclinical and clinical imaging in humans.
Department of Nuclear Medicine, University Hospital, Münster, Germany.
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Riemann
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Schäfers
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Schober
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Schäfers
D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods; D015195:Drug Design; D006331:Heart Diseases / Q000175:diagnosis; D006801:Humans; D007553:Isotope Labeling; D051379:Mice; D023421:Models, Animal; D009369:Neoplasms / Q000628:therapy; D009422:Nervous System Diseases / Q000175:diagnosis; D049268:Positron-Emission Tomography / Q000295:instrumentation* / Q000379:methods*; D019275:Radiopharmaceuticals / Q000737:chemistry* / Q000627:therapeutic use; D051381:Rats; D013678:Technology, Pharmaceutical / Q000379:methods
D019275:Radiopharmaceuticals