C-geranylated chalcones from the stems of Angelica keiskei with superoxide-scavenging activity.
An ethyl acetate-soluble fraction of a methanol extract from the stems of Angelica keiskei was subjected to chromatographic separation to give three new chalcones, designated as xanthokeismins A-C (1-3), in addition to a known chalcone, xanthoangelol B (4). The structures of 1-3 were determined on the basis of the analysis of their spectroscopic data. Compounds 1-4 exhibited potent superoxide-scavenging activity.
Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga, Japan.
Nobuwa
N
Aoki
Mai
M
Muko
Emi
E
Ohta
Shinji
S
Ohta
D029969:Angelica / Q000737:chemistry; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007564:Japan; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013481:Superoxides / Q000494:pharmacology
D047188:Chalcones; D016166:Free Radical Scavengers; C531891:xanthokeismin A; C531892:xanthokeismin B; C531893:xanthokeismin C; D013481:Superoxides