Current topics in prevention of human T-cell leukemia virus type i infection: NF-kappa B inhibitors and APOBEC3.
Human T-cell leukemia virus type I (HTLV-I) is the first human retrovirus and causes adult T-cell leukemia/lymphoma (ATL). Constitutive activation of nuclear factor-kappa B (NF-kappa B) in the leukemic cells is essential for their growth and survival. Thus, NF-kappa B inhibitors have been attracting attention as a potential strategy to treat ATL. Recently, the field of retrovirus research has been stimulated by the discovery of an innate host defense factor, APOBEC3, against the retroviruses. HTLV-I is relatively resistant to the antiviral effects of APOBEC3. To clarify the resistance of HTLV-I against APOBEC3 might contribute to the design of effective therapeutic approaches.
Ohsugi
Takeo
T
Division of Microbiology and Genetics, Center for Animal Resources and Development, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan. ohsugi@gpo.kumamoto-u.ac.jp
Koito
Atsushi
A
D000071478:APOBEC Deaminases; D000328:Adult; D000818:Animals; D003564:Cytidine Deaminase; D043525:Cytosine Deaminase / Q000276:immunology / Q000494:pharmacology*; D015490:HTLV-I Infections / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D020672:I-kappa B Proteins / Q000276:immunology / Q000494:pharmacology*; D007113:Immunity, Innate; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000276:immunology; D018894:Reverse Transcriptase Inhibitors / Q000276:immunology / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D020672:I-kappa B Proteins; D016328:NF-kappa B; C000606204:NFKBIA protein, human; D018894:Reverse Transcriptase Inhibitors; D000072000:NF-KappaB Inhibitor alpha; D043525:Cytosine Deaminase; D000071478:APOBEC Deaminases; C502889:APOBEC3 proteins, human; D003564:Cytidine Deaminase