Synthesis and antitumor activity of a heterodinucleotide of BVDU and gemcitabine.
A heterodinucleotide comprising BVDU and Gemcitabine bound together by a 5',5'-pyrophospate bridge (BVDUp(2)dFdC) has been synthesized and evaluated as antitumor agent against AH13 rat sarcoma cells. BVDUp(2)dFdC showed a cytotoxicity similar to that of Gemcitabine.
Department of Chemical Sciences, University of Camerino, Camerino, Italy.
L
L
Cappellacci
P
P
Franchetti
P
P
Vita
R
R
Petrelli
M
M
Grifantini
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy; D000093542:Gemcitabine
D000964:Antimetabolites, Antineoplastic; D000998:Antiviral Agents; D003841:Deoxycytidine; C020235:brivudine; D001973:Bromodeoxyuridine; D000093542:Gemcitabine