Cervical esophageal web and celiac disease.
OBJECTIVE
There is paucity of prospective data on association between cervical esophageal webs and celiac disease. It is not clear whether all patients with cervical esophageal web need screening for celiac disease. Hence, the present study was carried out to determine the association of cervical esophageal web with celiac disease.


METHODS
This prospective study included consecutive patients with symptomatic cervical esophageal web diagnosed over a period of 4.5 years. Tissue transglutaminase antibody was measured in serum of each patient. Patients with elevated tissue transglutaminase antibody titer were subjected to esophagogastroduodenoscopy and biopsies were obtained from the descending duodenum to look for histological changes of celiac disease. Esophageal web was treated with bougie dilatation. Celiac disease was diagnosed on the basis of elevated tissue transglutaminase antibody and suggestive duodenal histology.


RESULTS
Twenty one patients were diagnosed to have cervical esophageal web. Eighteen (85.7%) had evidence of iron deficiency. Five (23.8%) patients with cervical esophageal web fulfilled criteria for diagnosis of celiac disease. All five had evidence of iron deficiency. None of these patients gave a history of chronic diarrhea. All patients were treated with bougie dilatation. Patients with celiac disease were advised of a gluten-free diet. All five celiac disease patients are free of dysphagia without recurrence after a mean follow up of 10 months (range: 3 to 16 months).


CONCLUSIONS
There is association between cervical esophageal web and celiac disease. All adult patients with cervical esophageal web and iron deficiency need screening for celiac disease even in the absence of chronic diarrhea.
Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. sarojksinha@hotmail.com
Saroj Kant
SK
Sinha
Chander Kamal
CK
Nain
Harsh Prasad
HP
Udawat
Kaushal Kishore
KK
Prasad
Reena
R
Das
Birinder
B
Nagi
Kartar
K
Singh
D000293:Adolescent; D000328:Adult; D000368:Aged; D018798:Anemia, Iron-Deficiency / Q000150:complications* / Q000473:pathology / Q000628:therapy; D001323:Autoantibodies / Q000097:blood; D002446:Celiac Disease / Q000150:complications* / Q000201:enzymology / Q000473:pathology / Q000628:therapy; D018753:Diet, Protein-Restricted; D004106:Dilatation; D004386:Duodenum / Q000473:pathology*; D016145:Endoscopy, Digestive System; D015154:Esophageal Motility Disorders / Q000150:complications* / Q000473:pathology / Q000628:therapy; D004947:Esophagus / Q000473:pathology*; D005260:Female; D019204:GTP-Binding Proteins; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D058085:Iron Compounds / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D011446:Prospective Studies; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000276:immunology; D016896:Treatment Outcome
D001323:Autoantibodies; D058085:Iron Compounds; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins