Relaxin increases elastase activity and protease inhibitors in smooth muscle cells from the myometrium compared with cells from leiomyomas.
We investigated the effect of relaxin on extracellular matrix remodeling in cultured myometrial compared with leiomyoma smooth muscle cells. Relaxin increases elastase activity and protease inhibitor expressions in myometrial smooth muscle cells, but no effect was observed in leiomyoma cells.
Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA. bchen@stanford.edu
Bertha
B
Chen
Yan
Y
Wen
Xiao Yun
XY
Yu
Mary Lake
ML
Polan
D002478:Cells, Cultured; D003094:Collagen / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004549:Elastin / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism* / Q000473:pathology; D032389:Myocytes, Smooth Muscle / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D009215:Myometrium / Q000378:metabolism* / Q000473:pathology; D010196:Pancreatic Elastase / Q000378:metabolism*; D011480:Protease Inhibitors / Q000378:metabolism*; D012065:Relaxin / Q000494:pharmacology*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D011480:Protease Inhibitors; D019715:Tissue Inhibitor of Metalloproteinase-1; D000515:alpha 1-Antitrypsin; D019716:Tissue Inhibitor of Metalloproteinase-2; D012065:Relaxin; D003094:Collagen; D004549:Elastin; D010196:Pancreatic Elastase