Glucoregulatory and order effects on verbal episodic memory in healthy adolescents after oral glucose administration.
The ingestion of oral glucose has been observed to facilitate memory performance in both elderly individuals and in young adults. However, fewer studies have investigated the effect of glucose on memory in children or adolescents. In the present study, the ingestion of a glucose laden drink was observed to enhance verbal episodic memory performance in healthy adolescents under conditions of divided attention, relative to a placebo drink. Further analyses found that this glucose memory facilitation effect was observed only in adolescents exhibiting better glucoregulatory efficiency. These findings demonstrate that the glucose memory facilitation effect can be generalised to younger individuals. The importance of controlling for treatment order in within-subjects designs investigating the glucose memory enhancement effect is also discussed.
School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital for Children, Perth, WA, Australia. msmith@meddent.uwa.edu.au
Michael A
MA
Smith
Jonathan K
JK
Foster
D000284:Administration, Oral; D000293:Adolescent; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects* / Q000502:physiology; D011939:Mental Recall / Q000187:drug effects; D009483:Neuropsychological Tests; D011795:Surveys and Questionnaires; D013997:Time Factors; D014706:Verbal Learning / Q000187:drug effects* / Q000502:physiology
D001786:Blood Glucose; D005947:Glucose