Measurement of oxygen saturation in the retina with a spectroscopic sensitive multi aperture camera.
We introduce a new multi aperture system capable of capturing six identical images of the human fundus at six different spectral bands. The system is based on a lenslet array architecture and is well suited for spectroscopy application. The multi-aperture system was interfaced with a fundus camera to acquire spectroscopic sensitive images of the retina vessel and ultimately to calculate oxygen saturation in the retina in vivo. In vitro testing showed that the system is able to accurately reconstruct curves of partially oxygenated hemoglobin. In vivo testing on healthy volunteers was conducted and yielded results of oxygen saturation similar to the one reported in the literature, with arterial SO(2) approximately 0.95 and venous SO(2) approximately 0.5.
The Catholic University of America, Washington, D.C., USA. ramella@cua.edu
Jessica C
JC
Ramella-Roman
Scott A
SA
Mathews
Haryipriya
H
Kandimalla
Afshin
A
Nabili
Donald D
DD
Duncan
Salvatore A
SA
D'Anna
Syed Mahmood
SM
Shah
Quan Dong
QD
Nguyen
D002138:Calibration; D005654:Fundus Oculi; D006454:Hemoglobins; D006801:Humans; D008543:Melanins / Q000378:metabolism; D009010:Monte Carlo Method; D010100:Oxygen / Q000378:metabolism*; D012160:Retina / Q000378:metabolism*; D012171:Retinal Vessels / Q000378:metabolism; D013057:Spectrum Analysis / Q000379:methods*; D014867:Water
D006454:Hemoglobins; D008543:Melanins; D014867:Water; D010100:Oxygen