Expeditive synthesis of glycodendrimer scaffolds based on versatile TRIS and mannoside derivatives.
A new family of glycodendrimer scaffolds containing 12 and 18 peripheral alpha-d-mannopyranosidic units has been synthesized by Cu(I)-catalyzed [1,3]-dipolar cycloadditions using sulfurated dendritic scaffolds bearing alkyne functionalities and novel TRIS derivatives.
Department of Chemistry, Université du Québec à Montréal, P.O. Box 8888, Succ. Centre-Ville Montréal, Québec, Canada H3C 3P8.
Yoann M
YM
Chabre
Christiane
C
Contino-Pépin
Virginie
V
Placide
Tze Chieh
TC
Shiao
René
R
Roy
D000107:Acetylation; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D008362:Mannosides / Q000737:chemistry*; D015394:Molecular Structure; D011407:Propane / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry; D014325:Tromethamine / Q000737:chemistry*
D050091:Dendrimers; D008362:Mannosides; D013438:Sulfhydryl Compounds; D014325:Tromethamine; D011407:Propane