Primary hemorrhagic stroke in a 12-year-old female with sickle cell disease and normal transcranial Doppler.
Stroke is a well-known complication of sickle cell disease (SCD). It is estimated to occur in approximately 11% of patients with SCD by the age of 20. The most frequent cause of cerebrovascular accident (CVA) is blockage of the intracranial internal carotid and middle cerebral arteries. Hemorrhagic stroke is less common, occurring in approximately 3% of children by age 20. Transcranial Doppler (TCD) is the standard test for prediction of stroke risk in children with sickle cell anemia. The authors present a case of a 12-year-old female with SCD transferred to their institution after suffering a catastrophic intracranial hemorrhage. Her most recent TCD was normal 6 months prior to her admission.
New York Presbyterian Hospital-Weil Cornell Medical College, Division of Pediatric Critical Care Medicine, New York, NY, USA. mjw9005@nyp.org
Michael
M
Wolf
Carla
C
Cangemi
Richard
R
Drachtman
Margaret
M
Masterson
D000755:Anemia, Sickle Cell / Q000150:complications*; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000209:etiology*; D002648:Child; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D020521:Stroke / Q000175:diagnosis / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D017585:Ultrasonography, Doppler, Transcranial