Half-ball lens couples a beveled fiber probe for depth-resolved spectroscopy: Monte Carlo simulations.
In this study, we propose a beveled fiber-optic probe coupled with a half-ball lens for improving the depth-resolved fluorescence measurements of epithelial tissue. The Monte Carlo (MC) simulation results show that for a given excitation-collection fiber separation, the probe design with a bevel-angled collection fiber is more sensitive to detect fluorescence photons emitted from the shallow layer of tissue, whereas the flat-tip collection fiber is in favor of probing fluorescence photons originating from deeper tissue areas. This compact half-ball lens-beveled fiber probe design has the potential to facilitate the depth-resolved fluorescence detection of epithelial tissue.
Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore 117576.
Franck
F
Jaillon
Wei
W
Zheng
Zhiwei
Z
Huang
D000818:Animals; D003198:Computer Simulation; D004848:Epithelium / Q000648:ultrastructure; D005336:Fiber Optic Technology; D006801:Humans; D009010:Monte Carlo Method; D055100:Optical Fibers; D013057:Spectrum Analysis / Q000379:methods