Midbrain lesions and paroxysmal dysarthria in multiple sclerosis.
We describe three patients with relapsing-remitting multiple sclerosis who presented with paroxysmal dysarthria. In one patient, the symptoms were the only manifestation of an acute relapse. In the other two patients, the attacks appeared during the recovery of a brainstem relapse. All three patients had an acute lower midbrain lesion. The location was central in two patients and left paramedian in the other, and probably involving cerebellothalamocortical pathways. Treatment with carbamazepine was effective.
Service of Neurology, Hospital Clinic, Universitat de Barcelona and IDIBAPS, Villaroel 170, Barcelona, Spain.
Y
Y
Blanco
Y
Y
Compta
F
F
Graus
A
A
Saiz
D000927:Anticonvulsants / Q000627:therapeutic use; D001259:Ataxia / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D002220:Carbamazepine / Q000627:therapeutic use; D004401:Dysarthria / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000473:pathology*; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications / Q000473:pathology*; D012008:Recurrence; D013060:Speech
D000927:Anticonvulsants; D002220:Carbamazepine