Synthesis of glycose carbamides and evaluation of the induction of erythroid differentiation of human erythroleukemic K562 cells.
A series of carbamides derived from 1,2:5,6-di-O-isopropylidene-D-gluco- and D-allofuranose as well as their 5,6-O-deprotected analogues (2 and 4) and methyl 3,4-O-isopropylidene-alpha- and beta-D-galactopyranosides (5 and 6) have been prepared in order to evaluate their ability to induce erythroid differentiation of human erythroleukemic K562 cells. Twenty out of 51 carbamides tested exhibit an appreciable activity as inducers of erythroid differentiation and have been fully characterized and described.
Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Via Bonanno 33, I-56126 Pisa, Italy.
Martina
M
Landi
Giorgio
G
Catelani
Felicia
F
D'Andrea
Eleonora
E
Ghidini
Gabriele
G
Amari
Puccini
P
Paola
Nicoletta
N
Bianchi
Roberto
R
Gambari
D000970:Antineoplastic Agents / Q000737:chemistry; D002454:Cell Differentiation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D041905:Erythroid Cells / Q000187:drug effects; D005690:Galactose; D005947:Glucose; D006801:Humans; D020014:K562 Cells; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy / Q000473:pathology*; D009005:Monosaccharides / Q000138:chemical synthesis* / Q000494:pharmacology*; D010429:Pentoses; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives*
D000970:Antineoplastic Agents; D009005:Monosaccharides; D010429:Pentoses; D014508:Urea; D005947:Glucose; D005690:Galactose