The design of polyvalent therapeutics.
This article reviews recent developments in the design of polyvalent ligands for in vivo applications. Topics discussed include the design of polyvalent inhibitors of toxins and viruses, the use of polyvalency for targeted drug delivery and imaging, and applications of polyvalency for enhancing or suppressing immune responses.
The Howard P Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, NY 12180, USA.
Amit
A
Joshi
David
D
Vance
Prakash
P
Rai
Aditya
A
Thiyagarajan
Ravi S
RS
Kane
D000818:Animals; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D011485:Protein Binding
D007166:Immunosuppressive Agents; D008024:Ligands