Rhodium-catalyzed tandem conjugate addition-Mannich cyclization reaction: straightforward access to fully substituted tetrahydroquinolines.
A new Rh(I)-catalyzed tandem conjugate addition-Mannich cyclization reaction of imine-substituted electron-deficient alkenes with arylboronic acids has been developed to afford 2,3,4-trisubstituted 1,2,3,4-tetrahydroquinolines. This is the first example involving imine group as a secondary electrophile in Rh(I)-catalyzed tandem reactions.
Youn
So Won
SW
Department of Chemistry, Pukyong National University, Nam-Gu, Busan 608-737, Korea. sowony@pknu.ac.kr <sowony@pknu.ac.kr>
Song
Ju-Hyun
JH
Jung
Dai-Il
DI