Initial fetal cardiovascular profile score predicts recipient twin outcome in twin-twin transfusion syndrome.
BACKGROUND
The aim of this study was to assess the relationship between cardiomyopathy and recipient twin (RT) outcome in twin-twin transfusion syndrome (TTTS).


METHODS
Fetal echocardiography and outcomes data in 62 consecutive pregnancies with TTTS were reviewed. The primary outcome was neonatal RT survival. The severity of RT cardiomyopathy at presentation was assessed by the cardiovascular profile score (CVPS). RT outcomes and odds of survival were compared between groups stratified by CVPS.


RESULTS
Overall neonatal survival for all fetuses was 61% (76 of 124). RT survival was 58% (36 of 62). Grouped by CVPS, RT survival was greater (50%) for those with CVPS > or = 9 and even higher (74%) for CVPS of 10. Among the components of the CVPS, atrioventricular valve regurgitation was associated with negative RT outcome. Other factors at presentation were not predictive of RT outcome.


CONCLUSIONS
A normal CVPS in the RT in TTTS is predictive of improved survival compared with an abnormal CVPS, even in RTs with minor deductions. Standard clinical staging did not predict outcome. Cardiac assessment by CVPS may improve clinical decision making and the timing of fetal interventions.
Fetal Care Center of Cincinnati, Divisions of Pediatric Cardiology, General, Thoracic, and Fetal Surgery, Cincinnati Children's Hospital and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Amy D
AD
Shah
William L
WL
Border
Timothy M
TM
Crombleholme
Erik C
EC
Michelfelder
D005260:Female; D005330:Fetofetal Transfusion / Q000000981:diagnostic imaging* / Q000401:mortality*; D006801:Humans; D009820:Ohio / Q000453:epidemiology; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D015996:Survival Rate; D014427:Twins; D014463:Ultrasonography