[Progress in researches on the mechanism of varicocele-induced male infertility].
Varicocele is one of the most common diseases in the male reproductive system. More and more attention has been drawn to the influence of varicocele on male reproduction recently. Although many experiments and achievements have been made, the mechanism of infertility in varicocele patients has not yet been fully understood. The development of the disease might be related to many factors such as microcirculation of the testis, vasoactive substance, reactive oxygen species, nitric oxide, hypoxia, immunology and apoptosis. Mostly these changes are not confined to one testis. Thus, it is of great significance to investigate the mechanism of male infertility induced by varicocele. This article updates the studies on the mechanism of infertility in varicocele males.
Lü
Yi-Qing
YQ
Department of Urology, Shanghai Institute of Andrology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China. Tristan_ren@hotmail.com
Chen
Bin
B
D006801:Humans; D007248:Infertility, Male / Q000209:etiology* / Q000473:pathology; D008297:Male; D014646:Varicocele / Q000150:complications* / Q000473:pathology