Expression of apoptosis related protein in skin lesions of lichen planus and its implication.
In order to investigate the role of Caspase-3 and Bax in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of Caspase-3 and Bax in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rate of Caspase-3 and Bax expression in lichen planus were significantly higher than that in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the increase of Caspase-3 and that of Bax in lichen planus. The expression of Caspase-3 and Bax might play an important role in the development of lichen planus.
Chen
Xu'e
X
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. CXE911@hotmail.com
Wu
Yan
Y
Li
Jiawen
J
Liu
Zhixiang
Z
Yue
Qing
Q
Liu
Houjun
H
D000328:Adult; D017209:Apoptosis; D001706:Biopsy; D053148:Caspase 3 / Q000096:biosynthesis*; D005260:Female; D005786:Gene Expression Regulation; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008010:Lichen Planus / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D012867:Skin / Q000378:metabolism* / Q000473:pathology*; D051028:bcl-2-Associated X Protein / Q000096:biosynthesis* / Q000378:metabolism
D051028:bcl-2-Associated X Protein; D053148:Caspase 3