TiO2 nanoparticles promote beta-amyloid fibrillation in vitro.
Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. The pathogenesis of AD is associated with beta-amyloid (Abeta) fibrillation. Nanoparticles have large surface area and can access the brain. But no investigation has been made to study the relationship between nanoparticles and AD. In our study, we observed Abeta fibril formation in the presence of six kinds of nanoparticles and found that TiO2 nanoparticles can promote Abeta fibrillation by shortening nucleation process, which is the key rate-determining step of fibrillation. Hereby the interaction between Abeta and nanoparticles may contribute to AD etiology.
Wu
Wei-Hui
WH
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
Sun
Xun
X
Yu
Ye-Ping
YP
Hu
Jia
J
Zhao
Lei
L
Liu
Qian
Q
Zhao
Yu-Fen
YF
Li
Yan-Mei
YM
D000544:Alzheimer Disease / Q000209:etiology*; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D002563:Cerium / Q000737:chemistry; D004781:Environmental Exposure; D037741:Fullerenes / Q000737:chemistry; D006801:Humans; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000737:chemistry; D014025:Titanium / Q000737:chemistry* / Q000633:toxicity; D015040:Zirconium / Q000737:chemistry
D016229:Amyloid beta-Peptides; D037741:Fullerenes; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); C069836:fullerene C70; C009495:titanium dioxide; D002563:Cerium; C030583:ceric oxide; D012822:Silicon Dioxide; D015040:Zirconium; D014025:Titanium; C028541:zirconium oxide