Extracorporeal methods in the treatment of poisoning.
Among the various ways of managing poisoning, haemodialysis may help in enhancing excretion of the toxic substance. We report a case, a Russian male, 35 years old, who was rushed to the Gleneagles Hospital Medan from the airport after being evacuated from Banda Aceh together with another older Russian who died as they arrived at the admission and Emergency Department. From the result of intensive allo anamnesis and the high anion gap metabolic acidosis, in the absence of disturbed renal and liver function, we presumed this patient was suffering from methanol intoxication. The time of exposure was approximately 70 hours before. The exact length of dialysis time to excrete the noxious substance from the blood without plasma methanol determination was difficult. Moreover the time elapsed from exposure to treatment had been approximately 70 hours, which means the optic nerve had been so long exposed to formic acid, the toxic metabolite of methanol, that the damage should have been very severe. Ethanol is also known to be an antidote of methanol, which can be given orally by nasogastric tube, or i.v. It should be given early, and plasma ethanol level should be closely monitored to make it effective and safe. This was also unavailable. Another antidote is fomepizole which is also as yet unavailable in Medan. Folic acid, thiamin, and i.v. folinic acid are also recommended by the literature, as well as oral steroid.
Lubis
Harun Rasyid
HR
Department of Internal Medicine Faculty of Medicine, University of North Sumatera, Medan. harunrasyid1011@yahoo.com
Lubis
A Rahim Rasyid
AR
Hariman
Herman
H
Parwis
Beby
B
D000328:Adult; D000931:Antidotes / Q000627:therapeutic use; D000431:Ethanol / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D000432:Methanol / Q000506:poisoning* / Q000633:toxicity; D006435:Renal Dialysis; D012997:Solvents / Q000506:poisoning / Q000627:therapeutic use* / Q000633:toxicity; D013997:Time Factors
D000931:Antidotes; D012997:Solvents; D000431:Ethanol; D000432:Methanol