Synthesis and mycobacterial growth inhibition activities of bivalent and monovalent arabinofuranoside containing alkyl glycosides.
Arabinofuranosides constitute one of the important components of cell wall structures of mycobacteria. With this importance of arabinofuranosides in mind, alkyl glycosides bearing arabinofuranoside trisaccharides were prepared, wherein the sugars were presented either in the monovalent or bivalent forms. Following the synthesis, the monovalent and bivalent alkyl glycosides were tested for their activities in a mycobacterial growth assay. The growth of the mycobacterial strain M. smegmatis was assessed in the presence of the alkyl glycosides and it was realized that the alkyl glycosides acted as inhibitors of the mycobacterial growth. The inhibition of the growth, caused by the above alkyl glycosides, was not observed for the arabinofuranose trisaccharide alone, without the alkyl groups, and for an alkyl glycoside bearing maltose as the sugar component.
Naresh
Kottari
K
Department of Organic Chemistry, Indian Institute of Science, Bangalore, 560 012, India.
Bharati
Binod Kumar
BK
Jayaraman
Narayanaswamy
N
Chatterji
Dipankar
D
D001087:Arabinonucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005026:Ethylene Glycols / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry*; D020102:Mycobacterium smegmatis / Q000187:drug effects* / Q000254:growth & development*; D014312:Trisaccharides / Q000737:chemistry
D001087:Arabinonucleosides; D005026:Ethylene Glycols; D006027:Glycosides; D014312:Trisaccharides; C013484:diethylene glycol