Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions.
Schaschke
Norbert
N
Fakultät für Chemie, Universität Bielefeld, Universitätsstrasse 25, 33615 Bielefeld, Germany. norbert.schaschke@uni-bielefeld.de
Assfalg-Machleidt
Irmgard
I
Machleidt
Werner
W
D000595:Amino Acid Sequence; D001665:Binding Sites; D056668:Cathepsin L; D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D003546:Cysteine Endopeptidases / Q000737:chemistry* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011487:Protein Conformation; D019802:Succinic Acid / Q000737:chemistry*
D004791:Enzyme Inhibitors; D010455:Peptides; D019802:Succinic Acid; D002403:Cathepsins; D003546:Cysteine Endopeptidases; C534281:CTSL protein, human; D056668:Cathepsin L