HIV-1 infected patients older than 50 years. PISCIS cohort study.
OBJECTIVE
The aim of this study is to characterize the ways in which older HIV-infected people differ from younger HIV-infected people.


METHODS
Prospective cohort study. PISCIS cohort includes newly attended HIV-infected subjects since January 1, 1998. Naive patients were selected. Two groups were defined: G1 (>or=50 years at time of diagnosis, n=493) and G2 (18-49 years, n=4511). Statistical analysis was performed using chi(2), Student's t test, Cox regression and linear mixed models.


RESULTS
G1 had different features: males (G1: 84% vs. G2: 75%, p<0.001), sexual transmission (52% vs. 32%, p<0.001), AIDS at first visit (38% vs. 22%, p<0.001). The follow-up was 6 years. Ninety-five percent of patients in G1 and 92% in G2 presented a detectable viral load (>or=500 copies/mm(3)) at the first visit (p=0.016). G1 presented lower CD4 levels with respect to G2 throughout the period but the increase of CD4 in G1 at the end of the study period was 254 cells/mm(3) whereas for G2 it was 196 cells/mm(3) (p<0.001). Mortality was 9% for G1 and 4% for G2 (p<0.001).


CONCLUSIONS
HIV-infected people diagnosed at the age of 50 years or older showed different features. They showed good viral and immunological response to HAART.
Navarro
G
G
Corporación Sanitaria Parc Tauli, Sabadell, Barcelona, Spain. gnavarro@tauli.cat
Nogueras
M M
MM
Segura
F
F
Casabona
J
J
Miro
J M
JM
Murillas
J
J
Tural
C
C
Ferrer
E
E
Jaén
A
A
Force
L
L
Vilaró
J
J
García
I
I
Masabeu
A
A
Altés
J
J
Esteve
A
A
Sued
O
O
Riera
M
M
Clotet
B
B
Podzamczer
D
D
Gatell
J M
JM
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load
D012367:RNA, Viral