Dendronpholides A-R, cembranoid diterpenes from the chinese soft coral Dendronephthya sp.
A systematic examination of the Chinese soft coral Dendronephthya sp. resulted in the isolation and characterization of 18 new cembranoid diterpenes, namely, dendronpholides A-R (2-19), along with 11-episinulariolide and an enantiomer of sandensolide. Their structures were determined through extensive spectroscopic (IR, MS, 2D NMR) data analyses and by comparison with those reported in literature. The cytotoxicity of several compounds against human tumor cell lines was also evaluated.
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.
Aiying
A
Ma
Zhiwei
Z
Deng
Leen
L
van Ofwegen
Mirko
M
Bayer
Peter
P
Proksch
Wenhan
W
Lin
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D004224:Diterpenes