[Linoleic acid emulsion on the peri-lesion skin of venal ulcers. Action and cicatrizant effect. Corpus study].
The authors present a clinical and documented follow up on the peri-lesion skin in 44 venal blood vessel ulcers which were treated by a hyper-oxygenized fatty acid emulsion. All the elderly in this study belonged to the Number 3 Health Department of the Valencia Sanitary Council. This study's protocol and its data collection register received a favourable report from the Committee on Research Ethics at the "La Plana" Hospital. With a total percentage of 60 in essential linoleic fatty acid, CORPITOLINOL 60, is the emulsion which has the greatest quantity of this element so necessary for human skin. In effect, this is the essential fatty acid which has the greatest presence in human skin, besides being a vital element for skin hydration and its viability to form part of a fundamental structure: intercellular layers in the corneum layer of the epidermis. On the other hand, in the hyper-oxygenation process, this product helps the skin to obtain molecules very similar to prostaglandins land 2 which favour tissue perfusion. The main objective of this study has been to evaluate, after the application of this emulsion over a four week time period, the reduction of erythema and peri-lesion hyperkeratosis in venal blood vessel ulcers. But at the same time, as a secondary objective, this study evaluated peri-lesion skin based on other criteria such as pruritus, lesions due to scratching, or edema; this study verified whether treatment of peri-lesion skin influences the cicatrisation of wounds, as well as treatment acceptance by health professionals and patients. Incidences of erythemas and hyperkeratosis totally disappeared in 40% and 50% of those cases, respectively; in those lesions where these symptoms continued after four weeks of treatment there was a significant reduction in the degree of both erythemas and hyperkeratosis, 25% in each case. These researchers consider that good treatment of peri-lesion skin combined with a standard cure protocol, using "Urgotul" as the primary dressing, helped to achieve an overall 45% cicatrisation rate plus an 80% total cicatrized surface area. To these results, these researchers noted fine tolerance for the treatment employed and a very high acceptability level for this treatment by health professionals. To sum up, the analysis of the results of this clinical study prove the efficiency of "Corpitol Emulsion"; in addition, its fine tolerance and its high acceptability level make this product adaptable to the treatment of venal blood vessel ulcers in lower limbs when these ulcers are caused by varicose veins or a have a mixed cause with varicose veins as a predominant factor.
Departament d'Infermeria, Universitat de València Estudi General. vicente.tormo@uv.es
Vicente Tormo
VT
Maicas
Iván Julián
IJ
Rochina
D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D017439:Cicatrix, Hypertrophic / Q000517:prevention & control*; D004655:Emulsions; D005260:Female; D006801:Humans; D019787:Linoleic Acid / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014647:Varicose Ulcer / Q000188:drug therapy* / Q000517:prevention & control
D004655:Emulsions; D019787:Linoleic Acid