The spray drying of unfractionated heparin: optimization of the operating parameters.
Unfractionated heparin is an anti-inflammatory mucoactive agent, with the potential to treat the inflamed and mucus-obstructed airways in patients with cystic fibrosis. In this study, unfractionated heparin has been spray-dried to produce spherical micronized particles in the size range 1-5 microm, which is suitable for delivery by dry-powder inhalation. Spray drying parameters have been optimized using a 2(4) factorial experimental design. The feed concentration and atomization spray flow rate have the greatest effects on recovery (typically 60%) and particle size.
Shur
Jagdeep
J
School of Pharmacy and Biomedical Sciences, Institute of Biomedical and Biomolecular Science, University of Portsmouth, Portsmouth, UK.
Nevell
Thomas G
TG
Shute
Janis K
JK
Smith
James R
JR
D000280:Administration, Inhalation; D000336:Aerosols; D002152:Calorimetry, Differential Scanning; D003550:Cystic Fibrosis / Q000378:metabolism / Q000473:pathology; D006493:Heparin / Q000008:administration & dosage*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011208:Powders
D000336:Aerosols; D011208:Powders; D006493:Heparin