Simultaneous determination of macrolides, sulfonamides, and other pharmaceuticals in water samples by solid-phase extraction and LC-(ESI) MS.
This paper describes a method for determining 11 pharmaceuticals in various water sources by SPE followed by LC-(ESI) MS. SPE was carried out with Oasis HLB and the recoveries were 33-67% for 250 and 100 mL sewage water, 55-77% for 500 mL river water and 72-98% for 1 L tap water, with the exception of sulfamethoxazole and omeprazole which showed lower recoveries in all kinds of sample. The LODs in river water were of 5 ng/L for sulfadiazine, trimethoprim, sulfamethazine, sulfamethoxazole, and ranitidine and 10 ng/L for the other compounds. The highest concentrations found in river waters were for sulfamethoxazole (50 ng/L). In influent sewage waters, ranitidine was the most commonly detected compound with a maximum value of 0.24 microg/L.
Department of Analytical Chemistry and Organic Chemistry, Universitat Rovira i Virgili, Tarragona, Spain.
Marta
M
Pedrouzo
Francesc
F
Borrull
Rosa Maria
RM
Marcé
Eva
E
Pocurull
D002853:Chromatography, Liquid / Q000379:methods*; D005618:Fresh Water / Q000032:analysis; D007202:Indicators and Reagents; D018942:Macrolides / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000032:analysis; D011899:Ranitidine / Q000032:analysis; D012722:Sewage / Q000737:chemistry; D052616:Solid Phase Extraction / Q000379:methods*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013449:Sulfonamides / Q000032:analysis*; D014874:Water Pollutants, Chemical / Q000032:analysis*; D014881:Water Supply / Q000032:analysis
D007202:Indicators and Reagents; D018942:Macrolides; D004364:Pharmaceutical Preparations; D012722:Sewage; D013449:Sulfonamides; D014874:Water Pollutants, Chemical; D011899:Ranitidine