Localization of transient receptor potential channel vanilloid subfamilies in the mouse larynx.
CONCLUSIONS
Laryngeal epithelium contains TRPV1, 2, 3 and 4, which may act as laryngeal nociceptors perceiving luminal noxious stimuli, play an important role in thermal sensation, osmotic sensation, and are also related to pathological conditions, such as inflammatory response, genesis of cough, asthma.


OBJECTIVE
Expression of TRPV1, 2, 3 and 4 in the normal CBA/J mouse larynx was analysed.


METHODS
CBA/J mice were used in this study. The localizations of TRPV1, 2, 3 and 4 in the laryngeal epithelium were investigated by immunohistochemistry.


RESULTS
Immunohistochemical study revealed the presence of TRPV1, 2, 3 and 4 in the laryngeal epithelial cells. TRPV1 and TRPV2 were often co-localized with substance P, while the co-localization of substance P and TRPV3 was rare and TRPV4 was not co-localized with substance P.
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. hamamoto-takao@ams.odn.ne.jp
Takao
T
Hamamoto
Masaya
M
Takumida
Katsuhiro
K
Hirakawa
Sachio
S
Takeno
Takaharu
T
Tatsukawa
D000818:Animals; D005931:Glottis / Q000378:metabolism; D007150:Immunohistochemistry; D007820:Laryngeal Mucosa / Q000378:metabolism*; D051379:Mice; D008808:Mice, Inbred CBA; D013373:Substance P / Q000378:metabolism; D050916:TRPV Cation Channels / Q000378:metabolism* / Q000502:physiology; D014827:Vocal Cords / Q000378:metabolism
D050916:TRPV Cation Channels; D013373:Substance P