Motor maps, seizures, and behaviour.
Atypically organised motor maps have been described in some people with epilepsy and we have modelled this in rats. Our goal is to more fully understand the mechanisms responsible for seizure-induced functional brain reorganisation and to reverse their effects. Here we present an overview of the relationship between neocortical motor maps, seizures, and interictal behaviour. To begin we summarise the observations of atypical motor maps with epilepsy and in animal models following experimentally induced seizures. Our novel experiments have established that motor map expansion is linked to a functional alteration of motor behaviour. Evidence for some of the putative brain mechanisms responsible for motor map size is discussed. Our successes reversing seizure-induced map expansion by two different methods are also briefly reviewed. Lastly, unanswered questions for possible future experimentation are posed.
Teskey
G Campbell
GC
Behavioural Neuroscience Research Group, Department of Psychology and the Epilepsy & Brain Circuits Program, Hotchkiss Brain Institute, University of Calgary.
Monfils
Marie H
MH
Behavioural Neuroscience Research Group, Department of Psychology and the Epilepsy & Brain Circuits Program, Hotchkiss Brain Institute, University of Calgary.
Flynn
Corey
C
Behavioural Neuroscience Research Group, Department of Psychology and the Epilepsy & Brain Circuits Program, Hotchkiss Brain Institute, University of Calgary.
Young
Nicole A
NA
Behavioural Neuroscience Research Group, Department of Psychology and the Epilepsy & Brain Circuits Program, Hotchkiss Brain Institute, University of Calgary.
van Rooyen
Francine
F
Behavioural Neuroscience Research Group, Department of Psychology and the Epilepsy & Brain Circuits Program, Hotchkiss Brain Institute, University of Calgary.
Henry
Luke C
LC
Behavioural Neuroscience Research Group, Department of Psychology and the Epilepsy & Brain Circuits Program, Hotchkiss Brain Institute, University of Calgary.
Ozen
Lana J
LJ
Behavioural Neuroscience Research Group, Department of Psychology and the Epilepsy & Brain Circuits Program, Hotchkiss Brain Institute, University of Calgary.
Henderson
Amy K
AK
Behavioural Neuroscience Research Group, Department of Psychology and the Epilepsy & Brain Circuits Program, Hotchkiss Brain Institute, University of Calgary.
Reid
Aylin Y
AY
Behavioural Neuroscience Research Group, Department of Psychology and the Epilepsy & Brain Circuits Program, Hotchkiss Brain Institute, University of Calgary.
Brown
Andrew R
AR
0000-0002-2305-9115
Behavioural Neuroscience Research Group, Department of Psychology and the Epilepsy & Brain Circuits Program, Hotchkiss Brain Institute, University of Calgary.
D000818:Animals; D001931:Brain Mapping / Q000379:methods*; D004558:Electric Stimulation / Q000379:methods; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D009044:Motor Cortex / Q000033:anatomy & histology / Q000378:metabolism* / Q000503:physiopathology*; D049268:Positron-Emission Tomography; D051381:Rats