Influence of G308A polymorphism of tumor necrosis factor alpha gene on surgical results of biliopancreatic diversion.
BACKGROUND
Bariatric surgery is the most effective long-term treatment for morbid obesity, reducing obesity-associated comorbidities. The purpose of the present study was to evaluate G308A polymorphism of the tumor necrosis factor (TNF) alpha gene on outcomes 1 year after biliopancreatic diversion.


METHODS
A sample of 41 morbidly obese patients (body mass index > 40 kg/m(2)) were operated on. Weight, fat mass, blood pressure, creatinine, uric acid, basal glucose, triacylglycerols, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were measured at basal visit and at each visit. Adipocytokines were measured at basal time and 12 months after surgery. The frequency of patients with diabetes mellitus, hypertension, and hyperlipidemia was recorded at each visit.


RESULTS
Thirty-two patients (78%) had genotype G308G [wild-type group and nine patients (22%) with G308A genotype (mutant-type group)]. Genotype A308A was not detected. In the wild group, body mass index, weight, uric acid, glucose, total cholesterol, low-density lipoprotein cholesterol, triacylglycerol, leptin, and systolic blood pressure decreased. In the mutant group, the same parameters improved. Adiponectin levels increased after surgery in both genotypes. Initial weight percent loss at 1 year of follow up was similar in both groups (32.2% vs 28.6%; ns).


CONCLUSIONS
The present study demonstrates that the G308A polymorphism in the TNF-alpha gene is not related to clinical outcomes after bariatric surgery.
de Luis
D A
DA
Unit of Investigation, Surgical Department, Hospital Rio Hortega, Institute of Endocrinology and Nutrition, Medicine School, University of Valladolid, Simancas 47130, Valladolid, Spain. dadluis@yahoo.es
Pacheco
D
D
Aller
R
R
González Sagrado
M
M
Izaola
O
O
Terroba
M C
MC
Cuellar
L
L
Conde
R
R
Martin
T
T
D054392:Adipokines / Q000097:blood; D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D015904:Biliopancreatic Diversion; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009767:Obesity, Morbid / Q000097:blood / Q000235:genetics / Q000601:surgery*; D011110:Polymorphism, Genetic; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D015431:Weight Loss / Q000502:physiology*
D054392:Adipokines; D001786:Blood Glucose; D014409:Tumor Necrosis Factor-alpha; D002784:Cholesterol