Self-assembling peptides: from bio-inspired materials to bone regeneration.
In recent years, the development of new biomaterials with specifications for tissue and organ functional requirements-such as proper biological, structural, and biomechanical properties as well as designed control for biodegradation and therapeutic drug-release capacity-is the main aim of many academic and industrial programs. Hence, the concept of molecular self-assembly is the driving force for the development of new biomaterials that support the growth and functional differentiation of cells and tissues in a controlled manner. The discovery, properties, and development of self-assembling peptides to be used as three-dimensional (3D) scaffolds based on their similarity (in structure and mechanical features) to extracellular matrices are described. Self-assembling peptides can be used for in vitro applications for cell 3D culture as well as in vivo for tissue regeneration such as bone and optical nerve repair, as well as for drug delivery of mediators to improve therapy, as in the case of myocardial infarction. Finally, the use of self-assembling materials in combination with a bioengineering platform is proposed to assist functional bone regeneration in cases of larger bone defects, including exposed fractures due to trauma and spinal disorders dealing with high loadings, as well as replacement of big bone structures due to tumors.
Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. semino@mit.edu
C E
CE
Semino
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D001861:Bone Regeneration; D006801:Humans; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D015202:Protein Engineering / Q000379:methods*; D021122:Protein Subunits / Q000737:chemistry; D044968:Regenerative Medicine / Q000379:methods*; D054457:Tissue Scaffolds
D001672:Biocompatible Materials; D010455:Peptides; D021122:Protein Subunits