Role of axonal transport in neurodegenerative diseases.
Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies including abnormal accumulations of proteins and organelles. Such pathologies highlight damage to the axon as part of the pathogenic process and, in particular, damage to transport of cargoes through axons. Indeed, we now know that disruption of axonal transport is an early and perhaps causative event in many of these diseases. Here, we review the role of axonal transport in neurodegenerative disease.
De Vos
Kurt J
KJ
MRC Center for Neurodegeneration Research, Institute of Psychiatry, King's College, London SE5 8AF, United Kingdom. Kurt.DeVos@iop.kcl.ac.uk
Grierson
Andrew J
AJ
Ackerley
Steven
S
Miller
Christopher C J
CC
D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D001370:Axonal Transport / Q000235:genetics*; D001369:Axons / Q000378:metabolism* / Q000473:pathology; D002490:Central Nervous System / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002607:Charcot-Marie-Tooth Disease / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D016472:Motor Neuron Disease / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000378:metabolism* / Q000503:physiopathology; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology