Voriconazole-induced neuropathy.
BACKGROUND
Fungal infections are common and life threatening among immunosupressive patients. Rare side effects may occur related to the use of voriconazole, which is the drug of choice in invasive aspergillosis.


METHODS
Neuropathy was determined through clinical and electromyographic findings during the course of voriconazole therapy in 2 patients developing invasive aspergillosis.


RESULTS
Since examinations revealed no neuropathy capable of ascription to any other cause and improvement followed the cessation of the drug, this suggested that neuropathy may be linked to voriconazole use.


CONCLUSIONS
Neuropathy may be seen as a side effect during voriconazole treatment. Voriconazole-induced side effects should be borne in mind and patients carefully monitored during its use.
Aksoy
Firdevs
F
Department of Infectious Disease and Clinical Microbiology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey. faslanaksoy@yahoo.com
Akdogan
Elif
E
Aydin
Kemalettin
K
Yilmaz
Mustafa
M
Altunayoglu
Vildan
V
Sozen
Ebru Emel
EE
Omay
Serdar Bedii
SB
Koksal
Iftihar
I
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced*; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D014230:Triazoles / Q000009:adverse effects* / Q000627:therapeutic use; D065819:Voriconazole
D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole