Use of Luprostiol and Cloprostenol for induction of parturition in pregnant goats.
Pregnant goats were induced to parturition on day 145 of pregnancy, with three different protocols: group Cl (n = 19) was injected intramuscularly (IM) with 75 microg of the prostaglandin analogue R-Cloprostenol; group L (n = 20) was treated IM with 7.5 mg of the prostaglandin analogue Luprostiol; group L(50) (n = 18) was injected IM with 3.75 mg of Luprostiol (IM); in addition, Group S (Control, n = 15) was injected IM with 1 ml of saline solution. Thereafter, goats were continuously observed to record the following parameters: parturition, dystocia incidence, placental delivery and kid and maternal survival. Moreover, blood sampling was performed around kidding and plasma progesterone concentrations were analyzed. The interval from injection to parturition (mean +/- SEM) was not significantly different among the experimental groups: 35.1 +/- 1.5 h, 33.3 +/- 0.9 h and 34.1 +/- 1.8 h (groups Cl, L and L(50), respectively). In the control group, time to parturition was 99.4 +/- 12.1 h (range: 34-166 h). All the goats expelled the foetal membranes within the first 2 h after the induction. The incidence of dystocia due to foetal posture was not significantly different between induced and control goats (21.1%, 20.0%, 22.0% and 20%, for groups Cl, L, L(50) and S, respectively). The percentage of live kids was practically similar between induced goats (93.9%, 94.9% and 92.1%, for groups Cl, L and L(50), respectively); in addition, there was a case of maternal mortality in control group (6.7%; 1/15), whereas there was no mortality in induced goats (0%; 0/57). Plasma concentrations of progesterone showed an intense drop (<2 ng/ml) at 24 h after induction. This study confirms the effectiveness of the luprostiol to induce the parturition in goats, within a narrow range (30-40 h) in most of the induced females (80.0%, 7.5 mg; 77.8%, 3.75 mg).
Reproduction and Obstetrics, Veterinary Faculty, University of Las Palmas de Gran Canaria, Spain. mbatista@dpat.ulpgc.es
M
M
Batista
T
T
Niño
D
D
Alamo
F
F
González
M
M
Santana
N
N
Rodríguez
F
F
Cabrera
A
A
Gracia
D000818:Animals; D003008:Cloprostenol / Q000008:administration & dosage*; D004973:Estrus Synchronization; D005260:Female; D015511:Goat Diseases / Q000453:epidemiology; D006041:Goats / Q000502:physiology*; D007273:Injections, Intramuscular; D007751:Labor, Induced / Q000379:methods / Q000662:veterinary*; D007744:Obstetric Labor Complications / Q000453:epidemiology / Q000401:mortality / Q000662:veterinary; D036801:Parturition / Q000187:drug effects*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage*; D013997:Time Factors
D011461:Prostaglandins F, Synthetic; D003008:Cloprostenol; D011374:Progesterone; C049643:luprostenol