Living on a break: cellular senescence as a DNA-damage response.
Cellular senescence is associated with ageing and cancer in vivo and has a proven tumour-suppressive function. Common to both ageing and cancer is the generation of DNA damage and the engagement of the DNA-damage response pathways. In this Review, the diverse mechanisms that lead to DNA-damage generation and the activation of DNA-damage-response signalling pathways are discussed, together with the evidence for their contribution to the establishment and maintenance of cellular senescence in the context of organismal ageing and cancer development.
d'Adda di Fagagna
Fabrizio
F
IFOM Foundation, FIRC Institute of Molecular Oncology Foundation, via Adamello 16, 20139 Milan, Italy. fabrizio.dadda@ifom-ieo-campus.it
D000818:Animals; D016922:Cellular Senescence / Q000235:genetics*; D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000473:pathology