Alginate microsphere-collagen composite hydrogel for ocular drug delivery and implantation.
A composite collagen hydrogel containing protein encapsulated alginate microspheres was developed for ocular applications. Bovine serum albumin (BSA) served as a drug model. The composite hydrogel retained optical clarity and mechanical robustness of control hydrogels without microspheres. A sustained release of BSA was achieved during an 11-day period in neutral phosphate buffer. The composite hydrogel supported human corneal epithelial cell growth and had adequate mechanical strength and excellent optical clarity for possible use as therapeutic lens for drug delivery and/or use as corneal substitute for transplantation into patients who have corneal diseases.
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada, K1H8M5.
Wenguang
W
Liu
May
M
Griffith
Fengfu
F
Li
D000464:Alginates / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002417:Cattle; D002461:Cell Line, Transformed; D003094:Collagen / Q000737:chemistry*; D003315:Cornea / Q000166:cytology; D016503:Drug Delivery Systems / Q000379:methods*; D004548:Elasticity; D005123:Eye; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D008422:Materials Testing; D008863:Microspheres; D010316:Particle Size; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013552:Swine; D013718:Tensile Strength
D000464:Alginates; D001672:Biocompatible Materials; D006603:Hexuronic Acids; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D012710:Serum Albumin, Bovine; D020723:Glucuronic Acid; D003094:Collagen