Compatibility of doripenem with other drugs during simulated Y-site administration.
OBJECTIVE
The compatibility of doripenem diluted for infusion with 82 other drugs during simulated Y-site administration was studied.


METHODS
Five-milliliter samples of doripenem 5 mg/mL in 5% dextrose injection and separately in 0.9% sodium chloride injection were combined with 5 mL of 82 other drugs, undiluted or diluted in 5% dextrose injection or 0.9% sodium chloride injection. Visual examinations were performed with the unaided eye in fluorescent light and using a Tyndall beam to enhance visualization of small particles and low-level turbidity. The turbidity of each sample was measured, and particulate content was evaluated. Samples were inspected initially and one and four hours after preparation.


RESULTS
Of the drugs tested, doripenem 5 mg/mL in 5% dextrose injection and in 0.9% sodium chloride injection was incompatible with diazepam, potassium phosphates, and undiluted propofol. Doripenem 5 mg/mL in 0.9% sodium chloride injection but not in 5% dextrose injection was incompatible with amphotericin B-containing drugs due to the diluent. Doripenem was found to be compatible when combined with the other 75 drugs for at least four hours.


CONCLUSIONS
Doripenem 5 mg/mL in 5% dextrose injection or in 0.9% sodium chloride injection was physically compatible for four hours at room temperature with 75 drugs during simulated Y-site administration. Three drugs combined with doripenem in 5% dextrose injection or 0.9% sodium chloride injection and 7 drugs combined with doripenem in 0.9% sodium chloride injection resulted in unacceptable precipitation or an increase in measured haze and should not be simultaneously administered with doripenem admixtures.
Analytical Research Laboratories, Oklahoma City, OK, USA.
Matthew K
MK
Brammer
Pak
P
Chan
Kathy
K
Heatherly
Craig
C
Trusley
Thomas C
TC
Kupiec
Lawrence A
LA
Trissel
Petros A
PA
Psathas
Timothy
T
Gilmor
Daniel
D
Schaufelberger
D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D015780:Carbapenems / Q000008:administration & dosage*; D000077726:Doripenem; D004344:Drug Incompatibility; D007275:Injections, Intravenous; D009391:Nephelometry and Turbidimetry / Q000379:methods
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D000077726:Doripenem