Novel roles for collagens in wiring the vertebrate nervous system.
Wiring the vertebrate nervous system is a multi-step process that relies heavily upon the role of transmembrane and extracellular adhesion molecules. Despite the extensive attention focused on such molecules, collagens, a large family of structural adhesion molecules expressed in the vertebrate nervous system, have been largely overlooked for roles in neural circuit formation. Recently, however, several studies have unexpectedly identified novel roles of collagens and collagen-like molecules in the developing vertebrate nervous system. Here, contributions of these collagens and collagen-like molecules in neural circuit formation are reviewed.
Fox
Michael A
MA
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, 1101 East Marshall Street, PO Box 98-0709, Richmond, VA 23298-0709, USA. mafox@vcu.edu
D000818:Animals; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D002490:Central Nervous System / Q000033:anatomy & histology / Q000502:physiology; D003094:Collagen / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism; D016695:Glycosyltransferases / Q000235:genetics / Q000378:metabolism; D008240:Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism / Q000648:ultrastructure; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism
D015815:Cell Adhesion Molecules; D020033:Protein Isoforms; D029961:Zebrafish Proteins; C511783:plod3 protein, zebrafish; D003094:Collagen; D008240:Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; D016695:Glycosyltransferases