Acute toxicity of 2,4,6-trinitrotoluene, 2,4-dinitrotoluene, and 2,6-dinitrotoluene in the adult bullfrog (Lithobates catesbeiana).
2,4,6-Trinitrotoluene (TNT) is one of the most prevalent high explosives in the environment. 2,4-Dinitrotoluene (2,4-DNT) and 2,6-dinitrotoluene (2,6-DNT) are the most common isoforms of dinitrotoluene. The goal of this study was to determine the acute toxic effects of TNT, 2,4-DNT, and 2,6-DNT in adult male bullfrogs. The LD(50) for TNT was 1,060 mg/kg BW while the LD(50 )for 2,4-DNT and 2,6-DNT was 1,098 mg/kg BW. All three compounds elicited similar symptoms of toxicity including changes of skin color, body weight, development of seizures, liver and kidney necrosis, and lung cyanosis. Relative organ weights did not show significant change.
The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas 79409, USA. norka.paden@ttu.edu
Norka E
NE
Paden
Ernest E
EE
Smith
Ronald J
RJ
Kendall
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003490:Cyanosis / Q000139:chemically induced / Q000473:pathology; D004136:Dinitrobenzenes / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D053834:Explosive Agents / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008136:Longevity / Q000187:drug effects; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D009336:Necrosis / Q000139:chemically induced; D011892:Rana catesbeiana; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology; D012880:Skin Pigmentation / Q000187:drug effects; D014303:Trinitrotoluene / Q000633:toxicity*
D004136:Dinitrobenzenes; D053834:Explosive Agents; D014303:Trinitrotoluene; C016403:2,4-dinitrotoluene; C023514:2,6-dinitrotoluene