Structure and dynamic regulation of Src-family kinases.
Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src family share the same domain organization, with modular SH3, SH2 and kinase domains followed by a C-terminal negative regulatory tail. X-ray crystallographic analyses of several Src family members have revealed critical roles for the SH3 and SH2 domains in the down-regulation of the kinase domain. This review focuses on biological, biophysical, and computational studies that reveal conformationally distinct active states within this unique kinase family.
Department of Chemistry and Chemical Biology and the Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, Massachusetts, 02115, USA.
J R
JR
Engen
T E
TE
Wales
J M
JM
Hochrein
M A
MA
Meyn
S
S
Banu Ozkan
I
I
Bahar
T E
TE
Smithgall
D000818:Animals; D004789:Enzyme Activation; D006801:Humans; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D018909:src Homology Domains; D019061:src-Family Kinases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
D019061:src-Family Kinases