Medullary breast carcinoma.
More then half a million cases each year makes breast cancer the most common malignancy in female. Medullary breast carcinoma (MBC) is a type of invasive ductal breast carcinoma that usually has favorable prognosis and is characterized by the high graded structure, high mitotic rate and heavy lymphoid infiltration. The last feature makes MBC an attractive subject for detailed studies in respect to development of novel immunological approaches for cancer treatment. In this review we have summarized the data on MBC morphology, antigenic repertoire and molecular biology features. The aim of this review was to illuminate the unique biological features and to outline theoretical basis for further investigations of MBC.
Malyuchik
S S
SS
Institute of Molecular Biology and Genetics NAS of Ukraine, Kyiv, Ukraine. malyuchik@ukr.net
Kiyamova
R G
RG
D000818:Animals; D000941:Antigens / Q000378:metabolism; D000951:Antigens, Neoplasm / Q000737:chemistry; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D018276:Carcinoma, Medullary / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006680:HLA Antigens / Q000737:chemistry; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008207:Lymphatic Metastasis; D008214:Lymphocytes / Q000473:pathology; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology* / Q000628:therapy; D011379:Prognosis
D000941:Antigens; D000951:Antigens, Neoplasm; D006680:HLA Antigens