Anesthesia with propofol slows atrial fibrillation dominant frequencies.
The mechanisms responsible for the maintenance of atrial fibrillation (AF) are not completely understood yet. It has been demonstrated that AF can be modulated by several cardiac diseases, the autonomic nervous system and even drugs with purportedly no antiarrhythmic properties. We evaluated the effects of a widely used anaesthetic agent (propofol) in the fibrillation patterns. Spectral analysis was performed over atrial electrograms at baseline and immediately after a propofol bolus. Only after performing principal component analysis (PCA), we were able to significantly detect that propofol slows AF.
Cervigón
R
R
Escuela Universitaria Politécnica, Campus Universitario, Innovation in Bioengineering Research Group (GIBI), DIEEAC, UCLM, Camino del Pozuelo sn, 16071 Cuenca, Spain. raquel.cervigon@uclm.es
Moreno
J
J
Castells
F
F
Mateo
J
J
Sánchez
C
C
Pérez-Villacastín
J
J
Millet
J
J
D000368:Aged; D018686:Anesthetics, Intravenous / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000627:therapeutic use*
D018686:Anesthetics, Intravenous; D015742:Propofol