Factor VIIa interaction with tissue factor and endothelial cell protein C receptor on cell surfaces.
Factor VIIa (FVIIa) is the enzyme that triggers activation of the clotting cascade that eventually leads to fibrin deposition and platelet activation. Association of FVIIa with its cellular receptor, tissue factor (TF), which greatly increases FVIIa enzymatic activity, is essential for the effective initiation of the coagulation pathway. FVIIa also complexes with endothelial cell protein C receptor (EPCR), but this association does not increase the enzymatic activity of FVIIa. This article reviews current knowledge of FVIIa interaction with TF and EPCR on cell surfaces with a specific focus on how these interactions may contribute to FVIIa and TF clearance, thereby regulating TF-FVIIa activity.
Pendurthi
Usha R
UR
Biomedical Research, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA.
Rao
L Vijaya Mohan
LV
D015703:Antigens, CD / Q000502:physiology*; D001777:Blood Coagulation / Q000502:physiology; D042783:Endothelial Cells / Q000502:physiology; D000074283:Endothelial Protein C Receptor; D015942:Factor VIIa / Q000502:physiology*; D006801:Humans; D011956:Receptors, Cell Surface / Q000502:physiology*; D013925:Thromboplastin / Q000502:physiology*
D015703:Antigens, CD; D000074283:Endothelial Protein C Receptor; C478370:PROCR protein, human; D011956:Receptors, Cell Surface; D013925:Thromboplastin; D015942:Factor VIIa