[Polymorphism of LW blood group gene in Chinese population].
In order to study the polymorphism of Landsteiner-Wiener (LW) blood group gene in Chinese population, peripheral blood samples anticoagulated with EDTA from 160 unrelated volunteer blood donors were randomly collected, and genomic DNA were extracted. 160 DNA samples were analyzed for exon 1 of LW gene by direct DNA sequencing, and detected for LWa/LWb allele by improved PCR-SSP genotyping. The results showed that all LW allele in 160 donors were LWa homozygous, and the LWa allele occurred commonly. In conclusion, LWa allele occurs with incidence of 100% of donors in this study, while LWb allele has not been found in Chinese population.
Su
Yu-Qing
YQ
Shenzhen Blood Center, Shenzhen 518035, Guangdong Province, China. syq-susan@yahoo.com.cn
Yu
Qiong
Q
Liu
Xu
X
Liang
Yan-Lian
YL
Wei
Tian-Li
TL
D000483:Alleles; D044466:Asian People / Q000235:genetics; D001782:Blood Donors; D001789:Blood Group Antigens / Q000235:genetics*; D015815:Cell Adhesion Molecules / Q000235:genetics*; D005091:Exons / Q000235:genetics; D006720:Homozygote; D006801:Humans; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA
D001789:Blood Group Antigens; D015815:Cell Adhesion Molecules; C095100:ICAM4 protein, human