Signal amplification by conjugate addition for differential sensing with synthetic pores.
The Michael addition of hydrazide signal amplifiers to short-lived orthoquinone analytes is introduced as a new method to contribute toward the discrimination of polyphenols (e.g. epigallocatechin gallate, resveratrol) with synthetic pores.
Hagihara
Shinya
S
Department of Organic Chemistry, University of Geneva, Geneva, Switzerland.
Tanaka
Hiroyuki
H
Matile
Stefan
S
D001897:Boronic Acids / Q000737:chemistry; D002396:Catechols / Q000737:chemistry / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism; D006834:Hydrazines / Q000737:chemistry; D007473:Ion Channels / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D010636:Phenols / Q000737:chemistry / Q000378:metabolism; D059808:Polyphenols; D016062:Porosity; D011809:Quinones / Q000737:chemistry*; D015398:Signal Transduction; D013379:Substrate Specificity
D001897:Boronic Acids; D002396:Catechols; D005419:Flavonoids; D006834:Hydrazines; D007473:Ion Channels; D010636:Phenols; D059808:Polyphenols; D011809:Quinones