Association between 16S-23S internal transcribed spacer sequence groups of Mycobacterium avium complex and pulmonary disease.
Organisms within the Mycobacterium avium complex (MAC) may have differential virulence. We compared 33 subjects with MAC pulmonary disease to 75 subjects with a single positive culture without disease. M. avium isolates were significantly more likely to be associated with MAC pulmonary disease (odds ratio = 5.14, 95% confidence interval = 1.25 to 22.73) than M. intracellulare.
Stout
Jason E
JE
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. stout002@mc.duke.edu
Hopkins
Gregory W
GW
McDonald
Jay R
JR
Quinn
Anita
A
Hamilton
Carol D
CD
Reller
L Barth
LB
Frothingham
Richard
R
D000368:Aged; D016022:Case-Control Studies; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009162:Mycobacterium avium / Q000235:genetics* / Q000472:pathogenicity*; D015269:Mycobacterium avium Complex / Q000235:genetics* / Q000472:pathogenicity*; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D014397:Tuberculosis, Pulmonary / Q000382:microbiology*; D014774:Virulence
D004269:DNA, Bacterial; D021903:DNA, Ribosomal Spacer