Voriconazole-induced neuropathy.
BACKGROUND
Fungal infections are common and life threatening among immunosupressive patients. Rare side effects may occur related to the use of voriconazole, which is the drug of choice in invasive aspergillosis.


METHODS
Neuropathy was determined through clinical and electromyographic findings during the course of voriconazole therapy in 2 patients developing invasive aspergillosis.


RESULTS
Since examinations revealed no neuropathy capable of ascription to any other cause and improvement followed the cessation of the drug, this suggested that neuropathy may be linked to voriconazole use.


CONCLUSIONS
Neuropathy may be seen as a side effect during voriconazole treatment. Voriconazole-induced side effects should be borne in mind and patients carefully monitored during its use.
Department of Infectious Disease and Clinical Microbiology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey. faslanaksoy@yahoo.com
Firdevs
F
Aksoy
Elif
E
Akdogan
Kemalettin
K
Aydin
Mustafa
M
Yilmaz
Vildan
V
Altunayoglu
Ebru Emel
EE
Sozen
Serdar Bedii
SB
Omay
Iftihar
I
Koksal
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced*; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D014230:Triazoles / Q000009:adverse effects* / Q000627:therapeutic use; D065819:Voriconazole
D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole