Autoimmune oophoritis in the adolescent.
Autoimmune oophoritis presents in adolescents as a component of autoimmune polyendocrine syndrome type I or type II. Autoimmune oophoritis can be diagnosed in women with primary ovarian insufficiency in the presence of adrenal cortical or steroid cell antibodies, and/or antibodies to adrenal and ovarian steroidogenic enzymes. The ovaries are cystic macroscopically, with a lymphocytic infiltrate in the steroidogenic theca cells. The immune infiltrate results in low estradiol levels and a compensatory increase in FSH levels. Granulosa cells are spared, and inhibin A and B levels are normal to high. Treatment is aimed at symptom relief with further investigation needed to assess treatment options such as immunosuppression.
Welt
Corrine K
CK
Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. cwelt@partners.org
D000293:Adolescent; D001323:Autoantibodies; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007265:Inhibins / Q000097:blood; D009869:Oophoritis / Q000188:drug therapy / Q000276:immunology*; D010053:Ovary / Q000276:immunology / Q000473:pathology*; D016884:Polyendocrinopathies, Autoimmune / Q000188:drug therapy / Q000276:immunology*
D001323:Autoantibodies; D007166:Immunosuppressive Agents; C422362:inhibin A; C422364:inhibin B; D004958:Estradiol; D007265:Inhibins; D005640:Follicle Stimulating Hormone