Remission in the outpatient care of schizophrenia: 3-year results from the Schizophrenia Outpatients Health Outcomes (SOHO) study in France.
OBJECTIVE
To analyse the contribution of socio-demographics, clinical profile and psychotropic treatment on remission in patients with schizophrenia.


METHODS
Among 933 French outpatients recruited in the European observational Schizophrenia Outpatient Health Outcomes study (SOHO), 563 were followed-up for 3 years, had at most one missing visit, and were included in the analysis. Symptomatic remission was defined as a score of 3 (mild severity) or less on the Clinical Global Impression-Schizophrenia (CGI) overall, positive, negative and cognitive symptom scales, maintained for at least 6 months and without hospitalization. A logistic regression model was used to analyse the factors associated with time in remission.


RESULTS
60.6% of patients achieved remission during the 3-year follow-up. Patients never treated before inclusion in the study (OR=2.3) and those having paid employment (OR=1.4) were more likely to achieve remission. Higher baseline clinical severity was associated with a significantly lower likelihood of achieving remission: CGI overall (OR=0.67), CGI positive (OR=0.85) and CGI negative (OR=0.74). Compared with olanzapine, other atypicals (OR=0.71) and conventional antipsychotics (OR=0.69) were associated with a lower probability of achieving remission.


CONCLUSIONS
Remission can be achieved in a high proportion of patients. Factors such as being previously untreated, having paid employment and taking olanzapine are predictors of remission.
Gasquet
Isabelle
I
National Institute of Health and Medical Research-U669, Maison de Solenn, Cochin Hospital, Paris, France. isabelle.gasquet@sap.aphp.fr
Haro
Josep Maria
JM
Tcherny-Lessenot
Stéphanie
S
Chartier
Florence
F
Lépine
Jean-Pierre
JP
D000328:Adult; D000553:Ambulatory Care / Q000379:methods* / Q000706:statistics & numerical data*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D008297:Male; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D015995:Prevalence; D012074:Remission Induction; D012559:Schizophrenia / Q000145:classification / Q000188:drug therapy*; D012720:Severity of Illness Index; D013997:Time Factors