Enhancing effect of HT008-1 on cognitive function and quality of life in cognitively declined healthy adults: a randomized, double-blind, placebo-controlled, trial.
HT008-1 is one of the most effective multiherb mixtures that have neuroprotective effects in traditional Korean medicine. The purpose of this study was to conduct a clinical trial of the efficacy of HT008-1 on the neuropsychological functioning and quality of life (QoL) in cognitively intact adults. One hundred and eighteen male (n - 42) and female (n = 76) volunteers who reported no history of dementia or significant neurocognitive impairments and obtained Korean Version of Mini Mental State Examination total scores of at least 24 were examined via an 8-week, randomized, double-blind, fixed-dose, placebo-controlled, parallel group, clinical trial. Participants were randomly assigned to receive either HT008-1 (n = 59) or placebo (n = 59) for 8 weeks. Efficacy measures consisted of participants' performance scores from pretreatment baseline to those obtained just before termination of treatment on standardized neuropsychological measures from the subsets of Wechsler Memory Scale-III (WMS-III). QoL was assessed by subjective questionnaires WHOQoL-Bref about five categories. Participants who scored in the lower third of the Auditory recognition delayed at baseline and received HT008-1 exhibited improvement on the WMS-III Auditory recognition delayed subtest compared with placebo controls. The HT008-1 group also improved on general health scores in the QoL test.
Kim
Jongwoo
J
Stress Clinic, Kyung Hee University East-West Neo Medical Center, Seoul, Republic of Korea.
Chung
Sun Yong
SY
Park
Sojeong
S
Park
Jong-Hoon
JH
Byun
Soonim
S
Hwang
Manki
M
Oh
Dal-Seok
DS
Choi
Hyungsuk
H
Kim
Mi-Yeon
MY
Bu
Youngmin C
YC
Doré
Sylvain
S
Whang
Wei-Wan
WW
Kim
Hocheol
H
D000368:Aged; D002851:Chromatography, High Pressure Liquid; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000523:psychology*; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000032:analysis / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000009:adverse effects / Q000032:analysis / Q000627:therapeutic use*; D010936:Plant Extracts / Q000009:adverse effects / Q000032:analysis / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D014888:Wechsler Scales
D004365:Drugs, Chinese Herbal; C533064:HT008-1; D018697:Nootropic Agents; D010936:Plant Extracts