[Impact of neuroleptic-induced hyperprolactinemia on sexual dysfunction in male schizophrenic patients].
Human sexual function is complex and effected in many different ways by schizophrenia and the antipsychotic drugs used in its treatment. Although not extensively researched, sexual dysfunction seems to be frequent in patients with schizophrenia, especially in men. They appear, in significant part, to be a direct consequence of dopamine antagonism, combined with indirect effects due to increased serum prolactin (PRL) concentration. All of the typical antipsychotics and risperidone can cause substantial PRL elevation. Hyperprolactinemia in male schizophrenics might decrease libido, cause anorgasmia and lead to erectile dysfunction. These sexual side effects are closely associated with the patients' willingness to take antipsychotics, and can affect compliance.
Konarzewska
Beata
B
Klinika Chorób Psychicznych AM w Białymstoku.
Szulc
Agata
A
Popławska
Regina
R
Galińska
Beata
B
Juchnowicz
Dariusz
D
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004542:Ejaculation / Q000187:drug effects; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced*; D007989:Libido / Q000187:drug effects; D008297:Male; D009948:Orgasm / Q000187:drug effects; D018967:Risperidone / Q000009:adverse effects* / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy*; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced*
D014150:Antipsychotic Agents; D018967:Risperidone