Dye dependent differences in arteriovenous passage times: a comparison of indocyanine green and fluorescein sodium dye analysis.
OBJECTIVE
To evaluate the difference in arteriovenous passage time calculated from retinal angiograms using indocyanine green and fluorescein sodium dye in healthy individuals.


METHODS
Examinations of eight healthy individuals (mean age +/- standard deviation: 27.3 +/- 4.2 years) who had four consecutive ophthalmic visits that were 2 weeks apart were analyzed. Indocyanine green and fluorescein angiography were performed sequentially (with the indocyanine green angiography occurring first) using scanning laser ophthalmoscopy. Arteriovenous passage times were calculated offline using digital angiogram video analysis.


RESULTS
Mean arteriovenous passage times calculated from indocyanine green angiography (1.417 +/- 0.136 seconds) recordings were significantly shorter than fluorescein sodium times (2.539 +/- 0.421 seconds) (P < .0001) and intra-group variability was similar. There were no significant correlations between indocyanine green and fluorescein sodium arteriovenous passage times.


CONCLUSIONS
Arteriovenous passage times calculated using indocyanine green and fluorescein angiography are not interchangeable.
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Daniel T
DT
Sines
Larry
L
Kagemann
Brent
B
Siesky
Ehud
E
Rechtman
Hanna J
HJ
Garzozi
Alon
A
Harris
D000328:Adult; D001783:Blood Flow Velocity; D004396:Coloring Agents / Q000493:pharmacokinetics*; D019793:Fluorescein / Q000493:pharmacokinetics*; D005451:Fluorescein Angiography; D005456:Fluorescent Dyes / Q000493:pharmacokinetics*; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D009887:Ophthalmoscopy; D012039:Regional Blood Flow; D012161:Retinal Artery / Q000378:metabolism*; D012169:Retinal Vein / Q000378:metabolism*
D004396:Coloring Agents; D005456:Fluorescent Dyes; D007208:Indocyanine Green; D019793:Fluorescein