Enhancement in skin permeation of 5-aminolevulinic acid using l-menthol and its derivatives.
Enhancing effect of l-menthol and its derivatives, l-menthyl formate, l-menthyl acetate, and l-menthyl propionate, on skin permeation of 5-aminolevulinic acid (ALA) through Yucatan micropig full-thickness skin was investigated using a Franz-type diffusion cell. ALA solutions were prepared using ethanol-water mixed solvents with l-menthol or the derivative. Skin permeation coefficients (Kp) of ALA with more than 3.0 wt% of l-menthol was significantly larger than that without l-menthol. In addition, Kp of ALA with the derivative increased as follows: l-menthol approximately l-menthyl propionate < l-menthyl formate < l-menthyl acetate. These results suggest that l-menthol and the derivative are effective to enhance ALA skin permeation.
Faculty of Biomedical Engineering, Toin University of Yokohama, Aoba-ku, Yokohama, Japan. tokuoka@cc.toin.ac.jp
Yoshikazu
Y
Tokuoka
Megumi
M
Suzuki
Yumiko
Y
Ohsawa
Akira
A
Ochiai
Masahiro
M
Ishizuka
Norimichi
N
Kawashima
D000277:Adjuvants, Pharmaceutic / Q000494:pharmacology*; D000279:Administration, Cutaneous; D000622:Aminolevulinic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D000431:Ethanol / Q000494:pharmacology; D066298:In Vitro Techniques; D008610:Menthol / Q000494:pharmacology*; D010539:Permeability; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012869:Skin Absorption / Q000187:drug effects*; D013050:Spectrometry, Fluorescence; D013552:Swine; D013556:Swine, Miniature
D000277:Adjuvants, Pharmaceutic; D017319:Photosensitizing Agents; D008610:Menthol; D000431:Ethanol; D000622:Aminolevulinic Acid