Changes of serum adiponectin levels in murine experimental sparganosis.
The weight gain phenomenon associated with sparganosis has been well documented and was first recognized in the 1960s. Many studies have been conducted regarding the plerocercoid growth factor in the larva of Spirometra mansoni. In the present study, we hypothesized that the weight gain may be affected by the adipocyte secreted hormones, i.e., adiponectin, which is secreted from the adipose tissues in case of tissue migrating parasitic infections. Specifically, we attempted to ascertain whether the serum levels of adiponectin change in murine sparganosis. However, serum adiponectin levels assayed by ELISA evidenced no significant changes after an experimental infection (P > 0.05). Finally, the weight gain phenomenon in mouse sparganosis is not associated with changes in adiponectin levels, and further investigations involving parasitic infection-induced weight gain remain necessary.
Department of Parasitology and Ewha Global Challenge, Ewha Womans University, School of Medicine, Seoul, Korea. parayang@ewha.ac.kr
Hyun-Jong
HJ
Yang
D052242:Adiponectin / Q000097:blood*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D012911:Snakes; D013031:Sparganosis / Q000097:blood / Q000503:physiopathology*; D013032:Sparganum / Q000302:isolation & purification*; D015430:Weight Gain
D052242:Adiponectin