Contribution of structural biology to clinically validated target proteins.
We identified six groups of diseases expected to cause serious future health issues on the basis of a WHO report. Approved drugs for these diseases were associated with 409 target proteins; however, the percentage of selected proteins with full-length structural information deposited in the Protein Data Bank (PDB) was only 9.8%. The reason for the low percentage may be as a result of a disproportionate number of intractable proteins with multiple transmembrane regions and variable, or undefined glycosylation patterns, which impede protein preparation and crystallization, in such druggable proteins. We stress the importance of structural analysis of proteins, especially approved-drug target proteins, and the development of new methods to enable structural analyses of presently intractable proteins. In addition, we present an overview of large structural biology projects.
RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan.
Masumi
M
Mori
Naoko
N
Ogawa
Kunihiro
K
Tanikawa
Sanae
S
Dodo
Sotaro
S
Shibayama
Shigeyuki
S
Yokoyama
Akiko
A
Tanaka
D030562:Databases, Protein; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D011487:Protein Conformation; D011506:Proteins / Q000378:metabolism*
D011506:Proteins