Short-term effects of a novel fat emulsion on appetite and food intake.
The objective of the study was to confirm the satiety/energy intake effect of a novel fat emulsion (Olibra) versus placebo in the short term. A randomized, double-blind, placebo-controlled, crossover design was used. 41 subjects participated in the study (n=21: junior-normal weight: age 23.7+/-2.8 years; BMI: 22.0+/-1.6 kg/m(2); n = 20: senior-overweight: age 43.6+/-4.9 years; BMI: 27.7+/-1.6 kg/m(2)). An energy intake and satiety test (with questionnaires) took place on 2 occasions, with placebo or test yoghurt as breakfast. In the junior-normal weight subjects, consumption of test yoghurt reduced hunger and desire to eat during the morning (area under curve, p<0.05) and increased the time elapsed between consumption of the yoghurt and the point at which hunger scores returned to baseline; 234+/-79 min in the test condition compared to 174+/-58 min in the placebo condition (p<0.05). No significant differences in appetite scores between the test and placebo yoghurt were seen for the senior-overweight subjects. No effect on energy intake was seen in the total group, in the junior-normal weight and senior-overweight subjects. In conclusion, the Olibra emulsion exerted a suppressive effect on the area under the curve of appetite ratings over 3 h in normal weight women aged 18 to 30 years. The Olibra emulsion did not affect subsequent energy intake in either group.
Department of Human Biology, Maastricht University, Maastricht, The Netherlands.
Kristel
K
Diepvens
Jan
J
Steijns
Peter
P
Zuurendonk
Margriet S
MS
Westerterp-Plantenga
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D001066:Appetite / Q000187:drug effects*; D019540:Area Under Curve; D001835:Body Weight / Q000187:drug effects; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage*; D004311:Double-Blind Method; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D012527:Satiation / Q000187:drug effects; D011795:Surveys and Questionnaires; D013997:Time Factors
D004041:Dietary Fats