Finger representations in human primary somatosensory cortex as revealed by high-resolution functional MRI of tactile stimulation.
Fine-scale functional organization of the finger areas in the human primary somatosensory cortex was investigated by high-resolution BOLD MRI at 3 T using a multi-echo FLASH sequence with a voxel size of 2 mm(3). In six subjects independent tactile stimulation of the distal phalanx of the fingers of the right hand resulted in small circumscribed and barely overlapping activations precisely located along the posterior wall of the central sulcus. Three out of six subjects showed a complete succession of activation sites for all five fingers. The maps also allowed for the identification of individual variations in finger somatotopy. When registered onto the individual high-resolution MRI anatomy and compared with cytoarchitectonical maps, the finger representations were confirmed to lie within Brodmann area 3b as the main input region of the primary somatosensory cortex.
Schweizer
Renate
R
Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, 37070 Göttingen, Germany. renate.schweizer@mail.gwdg.de
Voit
Dirk
D
Frahm
Jens
J
D000328:Adult; D001931:Brain Mapping / Q000379:methods; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D005385:Fingers / Q000294:innervation* / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010812:Physical Stimulation / Q000379:methods*; D013003:Somatosensory Cortex / Q000502:physiology*; D014110:Touch / Q000502:physiology*; D055815:Young Adult