Evidence-based review of the Bioenterics intragastric balloon for weight loss.
We reviewed clinical studies performed with the Bioenterics intragastric balloon (BIB) to promote weight loss. Thirty studies were included [18 prospective (5 randomized), 12 retrospective], totaling 4,877 patients. Only one of three sham-controlled trials found a significantly higher weight loss with the BIB vs the sham procedure plus exhaustive follow-up. In nonrandomized studies, weight loss with the BIB averaged 17.8 kg (range, 4.9-28.5), corresponding to BMI changes of 4.0-9.0 kg/m(2). Comorbidities resolved or improved in 52-100% of patients. Best short-term results were observed in patients devoid of binge eating disorder with a BMI in the 30.0-40.0 kg/m(2) range; the BIB also helped to prepare superobese patients for bariatric surgery. Severe complications were exceptional (gastric perforation and intestinal obstruction; 0.2% each); digestive intolerance prompted early BIB removal in 2.5% of patients. Long-term (>or=2 years) results are awaited, as well as well-designed studies to define the best indications for this therapy.
Division of Gastroenterology and Hepatology, Geneva University Hospitals, Micheli-du-Crest Street, 24, 1205 Geneva, Switzerland. Jean-Marc.Dumonceau@hcuge.ch
Jean-Marc
JM
Dumonceau
D015992:Body Mass Index; D015897:Comorbidity; D000075202:Contraindications; D020878:Device Removal; D016099:Endoscopy, Gastrointestinal; D004867:Equipment Design; D015905:Gastric Balloon; D006801:Humans; D009767:Obesity, Morbid / Q000453:epidemiology / Q000628:therapy; D011788:Quality of Life; D016896:Treatment Outcome; D015431:Weight Loss