Ligand-directed nanobialys as theranostic agent for drug delivery and manganese-based magnetic resonance imaging of vascular targets.
Although gadolinium has been the dominant paramagnetic metal for MR paramagnetic contrast agents, the recent association of this lanthanide with nephrogenic systemic fibrosis, an untreatable disease, has spawned renewed interest in alternative metals for MR molecular imaging. We have developed a self-assembled, manganese(III)-labeled nanobialys (1), a toroidal-shaped MR theranostic nanoparticle. In this report, Mn(III) nanobialys are characterized as MR molecular imaging agents for targeted detection of fibrin, a major biochemical feature of thrombus. A complementary ability of nanobialys to incorporate chemotherapeutic compounds with greater than 98% efficiency and to retain more than 80% of these drugs after infinite sink dissolution, point to the theranostic potential of this platform technology.
C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, Missouri 63108, USA. dipanjan@wustl.edu
Dipanjan
D
Pan
Shelton D
SD
Caruthers
Grace
G
Hu
Angana
A
Senpan
Mike J
MJ
Scott
Patrick J
PJ
Gaffney
Samuel A
SA
Wickline
Gregory M
GM
Lanza
D001710:Biotin / Q000737:chemistry; D002166:Camptothecin / Q000008:administration & dosage / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D005337:Fibrin / Q000032:analysis / Q000737:chemistry; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008345:Manganese / Q000737:chemistry*; D008823:Micelles; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry
D008823:Micelles; D009942:Organometallic Compounds; D008345:Manganese; D001710:Biotin; D004317:Doxorubicin; D005337:Fibrin; D002166:Camptothecin