Experimental nodel of C6 brain tumors in athymic rats.
Malignant brain tumor experimental models tend to employ cells that are immunologically compatible with the receptor animal. In this study, we have proposed an experimental model of encephalic tumor development by injecting C6 cells into athymic Rowett rats, aiming at reaching a model which more closely resembles to the human glioma tumor. In our model, we observed micro-infiltration of tumor cell clusters in the vicinity of the main tumor mass, and of more distal isolated tumor cells immersed in normal encephalic parenchyma. This degree of infiltration is superior to that usually observed in other C6 models.
Department of Neurology, Medical School, University of São Paulo, São Paulo, Brazil. fkmiura@hotmail.com
Flávio K
FK
Miura
Maria José Ferreira
MJ
Alves
Mussya Cisotto
MC
Rocha
Roseli S
RS
Silva
Sueli M
SM
Oba-Shinjo
M
M
Uno
C
C
Colin
M C
MC
Sogayar
Sueli K N
SK
Marie
D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D005910:Glioma / Q000473:pathology*; D009361:Neoplasm Invasiveness; D051381:Rats; D011923:Rats, Nude