Intrastriatal injection of hypoxanthine impairs memory formation of step-down inhibitory avoidance task in rats.
The aim of this study was to investigate the effects of intrastriatal injection of hypoxanthine, the major compound accumulated in Lesch-Nyhan disease, on performance step-down inhibitory avoidance task in the rat. Male adult Wistar rats were divided in two groups: (1) saline-injected and (2) hypoxanthine-injected group. Treated-group received intrastriatal hypoxanthine solution 30 min before training session (memory acquisition) or immediately after training session (memory consolidation) or 30 before test session (memory retrieval) on step-down inhibitory avoidance task. Results show that hypoxanthine administration caused significant memory impairment in all periods tested. These results show that intrastriatal hypoxanthine administration provoked memory process impairment of step-down inhibitory avoidance task, an effect that might be related to the cognitive memory alterations in Lesch-Nyhan patients.
Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Caren Serra
CS
Bavaresco
Juliana
J
Ben
Fabria
F
Chiarani
Carlos Alexandre
CA
Netto
Angela Terezinha Souza
AT
Wyse
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001479:Basal Ganglia / Q000502:physiology; D019271:Hypoxanthine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D008845:Microinjections; D017072:Neostriatum; D051381:Rats; D017208:Rats, Wistar; D013238:Stereotaxic Techniques
D019271:Hypoxanthine