Edaravone improves the survival of rats subjected to hemorrhagic shock without resuscitation.
Our aim in this study was to find out whether edaravone (3-methyl-1-phenyl-pyrazolin-5-one, MCI-186), a novel free radical scavenger, improved the survival rate in a rat hemorrhagic shock (HS) model. Fifty male Sprague-Dawley rats were divided randomly into an edaravone group and a saline group. Both groups were subjected to HS by inducing a mean arterial pressure of 30 mmHg for 60 min without resuscitation. The edaravone group was divided into four subgroups based on when edaravone was given: 0, 15, 30, or 60 min after HS. The saline group was given saline immediately after HS. We evaluated the 24-h survival rate in each group. The survival rate of the edaravone subgroup given edaravone immediately after HS was significantly better than that of the saline group. Edaravone improved the survival rate in a rat HS without resuscitation model. Edaravone was most effective when given immediately after HS.
Department of Surgery, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga, 520-2121, Japan.
Yoshitaka
Y
Uji
Hiroshi
H
Yamamoto
Tsuyoshi
T
Mori
Hiroya
H
Akabori
Hiroshi
H
Tsuchihashi
Tomoharu
T
Shimizu
Yoshihiro
Y
Endo
Tohru
T
Tani
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004195:Disease Models, Animal; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000401:mortality / Q000628:therapy; D016019:Survival Analysis; D013997:Time Factors
D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine