Juvenile idiopathic arthritis-type disease associated with chromosomal aberrations.
The association of certain chromosome aberrations with arthropathy has been previously described, but there is a limited number of reports in the literature. Two children are described, one with 18q- syndrome and another with supernumary marker chromosome 15, both presenting with juvenile idiopathic arthritis-type disease, aggressive progression and moderate response to inflammatory, corticosteroid and immunosuppressive treatment.
Salavoura
K
K
Department of Medical Genetics, Athens University School of Medicine, Athens, Greece. akolial@cc.uoa.gr
Dracou
C
C
Kolialexi
A
A
Drakonaki
S
S
Sofocleous
C
C
Mavrou
A
A
D001171:Arthritis, Juvenile / Q000235:genetics* / Q000473:pathology; D002648:Child; D002869:Chromosome Aberrations; D002884:Chromosomes, Human, Pair 15; D002887:Chromosomes, Human, Pair 18; D005260:Female; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D010641:Phenotype
D005819:Genetic Markers