Synthesis and biological activity of mustard derivatives of thymine.
The synthesis and biological activity of a novel DNA cross-linking antitumor agent is presented. The new alkylating agent significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line.
Hadj-Bouazza
Amel
A
Laboratoire de Chimie des Substances Naturelles, Faculte des Sciences et Techniques Limoges, Universite de Limoges, France.
Teste
Karine
K
Colombeau
Ludovic
L
Chaleix
Vincent
V
Zerrouki
Rachida
R
Kraemer
Michel
M
Sainte Catherine
Odile
O
D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D006801:Humans; D020778:Matrix Metalloproteinase 2; D061965:Matrix Metalloproteinase Inhibitors; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D009588:Nitrogen Mustard Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013941:Thymine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
D018906:Antineoplastic Agents, Alkylating; D061965:Matrix Metalloproteinase Inhibitors; D009588:Nitrogen Mustard Compounds; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D013941:Thymine