Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure.
To identify genes that are associated with premature ovarian failure, a linkage disequilibrium-based genome-wide association study with dense single nucleotide polymorphisms as genetic markers was performed. The acyl-coenzyme A synthetase long-chain family member 6 (ACSL6) gene on chromosome 5q31 was associated with premature ovarian failure and identified disease-susceptibility haplotypes.
Kang
HyunJun
H
Medical Genomics Laboratory, Pochon CHA University, Gyeonggi-do, Korea.
Lee
Seung Ku
SK
Kim
Min-Ho
MH
Choi
HyeJeong
H
Lee
Sook-Hwan
SH
Kwack
KyuBum
K
D016022:Case-Control Studies; D002895:Chromosomes, Human, Pair 5; D003066:Coenzyme A Ligases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016649:Primary Ovarian Insufficiency / Q000235:genetics*
D003066:Coenzyme A Ligases; C403665:ACSL6 protein, human