[Effect of delta-sleep inducing peptide on free-radical processes in the brain and liver of mice during various light regimens].
Female SHR mice received 5-days long course of delta-sleep inducing peptide preparation "Deltaran" subcutaneously in daily dose of 5 mkg/mice per 24h under standard light regime (12h light: 12 h darkness) or constant illumination. Free-radical level and antioxidative activity in brain and liver was studied by standard methods. Constant illumination increased chemiluminescence in brain by 20 % and decreased liver glutationperoxidase activity by 60 %, as compared to the mice kept in standard light regime. In conditions of standard light regime deltaran increased levels of general antioxidative activity in brain by 9%, liver superoxide dismutase by 17% and lowered levels of glutationperoxidase of liver by 82%. In conditions of constant illumination Deltaran lowered levels of chemiluminescence in liver by 23%, raised the general antioxidative activity in liver by 19% and lowered levels of glutationperoxidase of liver by 69%. It was supposed that deltaran has an antioxidant effect under constant light regime.
V B
VB
Voĭtenkov
I G
IG
Popovich
A V
AV
Arutiunian
T I
TI
Oparina
V M
VM
Prokopenko
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005998:Glycine / Q000494:pharmacology*; D008027:Light; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D010507:Periodicity; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; C480301:Deltran; D005609:Free Radicals; D003701:Delta Sleep-Inducing Peptide; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005998:Glycine