Reduced biocide susceptibility in Candida albicans biofilms.
Candida biofilm formation is common during infection and environmental growth. We tested the impacts of three biocides (ethanol [EtOH], H(2)O(2), and sodium dodecyl sulfate) on Candida albicans, C. parapsilosis, and C. glabrata biofilms. Higher concentrations of the biocides were required for efficacy against biofilms than for efficacy against planktonic controls. A combination study with two biocides (EtOH and H(2)O(2)) and fluconazole demonstrated that the combination had enhanced efficacy.
Nett
Jeniel E
JE
Departments of Medicine, Cellular and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53792, USA.
Guite
Kristie M
KM
Ringeisen
Alex
A
Holoyda
Kathleen A
KA
Andes
David R
DR
D000935:Antifungal Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002175:Candida / Q000187:drug effects / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D041221:Candida glabrata / Q000187:drug effects / Q000254:growth & development; D004202:Disinfectants / Q000494:pharmacology*; D004347:Drug Interactions; D025141:Drug Resistance, Fungal; D004359:Drug Therapy, Combination; D000431:Ethanol / Q000494:pharmacology; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology
D000935:Antifungal Agents; D004202:Disinfectants; D012967:Sodium Dodecyl Sulfate; D000431:Ethanol; D015725:Fluconazole; D006861:Hydrogen Peroxide