Preventing tomorrow's sudden cardiac death in epilepsy today: what should physicians know about this?
Approximately 1% of the population has epilepsy, the most common neurological disorder. Moreover, people with epilepsy are more likely to die prematurely than those without epilepsy, and the most common epilepsy-related category of death is sudden unexpected death in epilepsy (SUDEP). Information concerning risk factors for SUDEP is conflicting, but potential risk factors include: age, early onset of epilepsy, duration of epilepsy, uncontrolled seizures, seizure frequency, number of antiepileptic drugs and winter temperatures. Additionally, the cause of SUDEP is still unknown; however, the most commonly suggested mechanisms are cardiac abnormalities during and between seizures. This review discusses the epidemiology, risk factors, etiology, and preventative measures in the management of SUDEP.
Laboratório de Neurologia Experimental, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
Fulvio A
FA
Scorza
Diego B
DB
Colugnati
Aline P
AP
Pansani
Eliza Y F
EY
Sonoda
Ricardo M
RM
Arida
Esper A
EA
Cavalheiro
D017668:Age of Onset; D000927:Anticonvulsants / Q000009:adverse effects; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000401:mortality; D002423:Cause of Death; D003080:Cold Temperature / Q000009:adverse effects; D016757:Death, Sudden, Cardiac / Q000517:prevention & control*; D004827:Epilepsy / Q000150:complications / Q000401:mortality* / Q000503:physiopathology; D006801:Humans; D015994:Incidence; D012307:Risk Factors; D012640:Seizures / Q000209:etiology
D000927:Anticonvulsants