Agelasines J, K, and L from the Solomon Islands Marine Sponge Agelas cf. mauritiana.
Three new diterpene alkaloids, agelasine J (3), agelasine K (4), and agelasine L (5), were isolated from the marine sponge Agelas cf. mauritiana collected in the Solomon Islands. The structures of these compounds were elucidated by physical data analyses. They displayed in vitro antimalarial activity against Plasmodium falciparum.
Institut de Chimie des Substances Naturelles du CNRS, 91198 Gif-sur-YVette, France.
Jérôme
J
Appenzeller
Ghezala
G
Mihci
Marie-Thérèse
MT
Martin
Jean-François
JF
Gallard
Jean-Louis
JL
Menou
Nicole
N
Boury-Esnault
John
J
Hooper
Sylvain
S
Petek
Severine
S
Chevalley
Alexis
A
Valentin
Anne
A
Zaparucha
Ali
A
Al-Mourabit
Cécile
C
Debitus
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013058:Mass Spectrometry; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D011161:Porifera
D000470:Alkaloids; D000962:Antimalarials; D004224:Diterpenes