Expression profile of interferon stimulated genes in central nervous system of mice infected with dengue virus Type-1.
Dengue virus (DENV) infection can cause a self-limiting disease (dengue fever) or a more severe clinical presentation known as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Furthermore, data from recent dengue epidemics in Brazil indicate that the neurological manifestations are becoming more prevalent. However, the neuropathogenesis of dengue are not well understood. The balance between viral replication efficiency and innate immunity--in opposition during the early stages of infection--determines the clinical outcome of DENV infection. In this study, we investigated the effects of DENV infection on the transcription profile of the central nervous system (CNS) of mice. We observed in infected mice the up-regulation of 151 genes possibly involved in neuropathogenesis of dengue. Conversely, they may have a protective effect. Ingenuity Systems software analysis demonstrated, that the main pathways modulated by DENV infection in the mouse CNS are involved in interferon signaling and antigen presentation.
Bordignon
Juliano
J
Instituto de Biologia Molecular do Paraná, Rua Prof Algacyr Munhoz Máder 3775, 81350-010, Curitiba, Paraná, Brazil.
Probst
Christian M
CM
Mosimann
Ana Luiza P
AL
Pavoni
Daniela P
DP
Stella
Vanessa
V
Buck
Gregory A
GA
Satproedprai
Nusara
N
Fawcett
Paul
P
Zanata
Sílvio M
SM
de Noronha
Lucia
L
Krieger
Marco A
MA
Duarte Dos Santos
Claudia N
CN
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects* / Q000821:virology; D003715:Dengue / Q000276:immunology / Q000473:pathology*; D003716:Dengue Virus / Q000276:immunology* / Q000472:pathogenicity; D020869:Gene Expression Profiling; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D012984:Software; D014158:Transcription, Genetic
D007372:Interferons