Microfluidic differential resistive pulse sensors.
This study demonstrates an on-chip resistive pulse-sensing scheme with a design of symmetric mirror channels, which significantly reduces the noise and achieves better signal-to-noise ratio. Polystyrene particles of different sizes have been detected with the developed sensing scheme and a record low volume ratio of the particle to the sensing channel, or 0.0004%, has been detected with particles of 520 nm in diameter in a sensing aperture of 50x16x20 microm3. This volume ratio is about ten times lower than the lowest volume ratio reported in the literature including that specified for commercial Coulter counters.
Wu
Xudong
X
Department of Biomedical Engineering, Chongqing University, Chongqing, P. R. China.
Kang
Yuejun
Y
Wang
Yao-Nan
YN
Xu
Dongyan
D
Li
Deyu
D
Li
Dongqing
D
D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods