Comparison of time-action profiles of insulin glargine and NPH insulin in normal and diabetic dogs.
Intermediate insulin injections are commonly used for glycemic control in insulin dependent diabetic dogs acting as a replacement for natural insulin. Neutral Protamin Hagedorn (NPH) insulin and insulin glargine are two types of injectable insulin preparations commonly used in humans. In our study, we investigated the time-action profiles of both aforementioned insulin preparations in normal dogs in order to determine whether co-administration of NPH and glargine would be of benefit to insulin dependent diabetic dogs as it is for humans suffering from insulin dependent diabetes. Time-action profiles of NPH insulin and insulin glargine in normal dogs demonstrated a clear difference between both insulin preparations confirming that NPH insulin is an intermediate-acting preparation whereas insulin glargine is a long-lasting preparation. In addition, co-administration of NPH insulin and insulin glargine resulted in tight glycemic control as compared to NPH insulin alone in insulin dependent diabetic dogs. However, co-administration result in hypoglycemia at the dosages tested.
Mori
A
A
Department of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan. D0608@nvlu.ac.jp
Sako
T
T
Lee
P
P
Motoike
T
T
Iwase
K
K
Kanaya
Y
Y
Fukuta
H
H
Mizutani
H
H
Arai
T
T
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D007328:Insulin / Q000031:analogs & derivatives* / Q000494:pharmacology; D000069036:Insulin Glargine; D007336:Insulin, Isophane / Q000494:pharmacology*; D049528:Insulin, Long-Acting; D007928:Lethal Dose 50; D008297:Male; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D049528:Insulin, Long-Acting; D000069036:Insulin Glargine; D007336:Insulin, Isophane