Ligand-free copper-catalyzed C-S coupling of aryl iodides and thiols.
A protocol for the copper-catalyzed aryl-sulfur bond formation between aryl iodides and thiophenols is reported. The reaction is catalyzed by a low amount (1-2.5 mol %) of readily available and ligand-free copper iodide salt. A variety of diaryl thioethers are synthesized under relatively mild reaction conditions with good chemoselectivity and functional group tolerance.
Chemical Biology and Organic Chemistry, Debye Institute for Nanomaterials Science, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
Elena
E
Sperotto
Gerard P M
GP
van Klink
Johannes G
JG
de Vries
Gerard
G
van Koten
D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry; D012997:Solvents; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*
D007454:Iodides; D008024:Ligands; D010636:Phenols; D012997:Solvents; D013438:Sulfhydryl Compounds; D013455:Sulfur; D002244:Carbon; D003300:Copper; C042983:thiophenol