[C1772T polymorphism of hypoxia-inducible factor-1 alpha gene in Han ethnic population from Northern China].
To analyze the distribution of single nucleotide polymorphism C1772T (SNP/C1772T) in hypoxia-inducible factor -1 alpha (HIF-1 alpha) gene in Han ethnic population from Northern China.



Allele frequencies in a sample of 206 healthy Chinese Hans were determined by polymerase chain reaction followed by restriction fragment length polymorphism.



The genotype frequencies of C1772T observed in Chinese Hans were 93 % and 7% for CC and CT respectively; and allele frequencies were 96% and 4 %for C and T respectively. There was significant difference in distribution of allele frequencies between Chinese Hans and Caucasian.



The single nucleotide polymorphism of C1772T in HIF-1 alpha gene has difference in different ethnic population.
Liu
Hai-Ping
HP
Department of Sports and Human Science, Wenzhou Medical College, Wenzhou 325035, China. liuhaip@126.com
Xu
Yang
Y
Jin
Chun-Yan
CY
D000293:Adolescent; D002681:China / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit