Copper(I)-promoted synthesis of chloromethyl ketones from trichloromethyl carbinols.
Reaction of several trichloromethyl carbinols with 2 equiv of CuCl/bpy in refluxing DCE for 3 h afforded chloromethyl ketones in excellent yield by 1,2-H shift in the copper-chlorocarbenoid intermediate.
Ram
Ram N
RN
Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi-110016, India. rnram@chemistry.iitd.ernet.in
Manoj
T P
TP
D017606:Chlorine Compounds / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D000432:Methanol / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure
D017606:Chlorine Compounds; D007659:Ketones; D003300:Copper; D000432:Methanol