New hope for cancer treatment: exploring the distinction between normal adult stem cells and cancer stem cells.
For decades, intensive studies have attempted to identify the mechanisms underlying malignant tumor growth. Despite significant progress, most therapeutic approaches fail to eliminate all tumor cells. The remaining tumor cells often result in recurrence and metastasis. Recently, the idea of a cancer stem cell was proposed to explain of the origin of cancer cells. According to this hypothesis, a small fraction of tumor cells have the capacity for self-renewal, with unlimited slow proliferation potential. They are often resistant to chemotherapy and radiation and thus are responsible for continuously supplying new cancer cells, which themselves may have a limited life span. In recent years, accumulating experimental evidence supports this hypothesis and provides new possibilities to conquer cancer. This review will focus on the distinction between normal adult stem cells and cancer stem cells and identifies possible key targets for effective therapies of cancer.
Institute of Basic Medical Sciences & School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, 5# Dongdansantiao, Beijing, 100005, PR China. chunhuaz@public.tpt.tj.cn
Robert Chunhua
RC
Zhao
Ya-Shu
YS
Zhu
Yufang
Y
Shi
D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation; D053823:Hedgehog Proteins / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D014411:Neoplastic Stem Cells / Q000166:cytology / Q000502:physiology*; D010641:Phenotype; D051880:Receptors, Notch / Q000502:physiology; D015398:Signal Transduction; D051153:Wnt Proteins / Q000502:physiology
D053823:Hedgehog Proteins; D051880:Receptors, Notch; D051153:Wnt Proteins