[Repairing the defect of benign bone tumor with the coralline hydroxyapatite].
OBJECTIVE
To observe the clinical effect of repairing bone defectin post-operation benign tumor with coralline hydroxyapatite(CHAP).


METHODS
The natural coralline was treated into coralline hydroxyapatite by "hydrothermal exchanging" at specific condition. The CHAP was implanted into the lesion after bone tumor curettage to 25 patients. The sizes of bone defect ranged from 0.8 cm x 0.5 cm x 0.5 cm to 10 cm x 3.5 cm x 2 cm.


RESULTS
All patients had no abnormal local or systemic reactions. X-ray showed that there was osteogenesis at the cortical bone 1 month post-operation. The density of CHAP gradually reduced from 3 months. The clinical healing time was 4 months. The CHAP was nearly completely absorbed 18 months post-operation.


CONCLUSIONS
The CHAP has favourable histocompatibility and osteroconduction in vivo. There is corresponding synchronization between bone formation with CHAP biodegradation. The CHAP is an excellent bone defect repairing material.
Fu
Kun
K
Department of Orthopaedics, Affiliated Hospital of Hainan Medical College, Haikou, China. fudh168@hotmail.com
Meng
Zhi-bin
ZB
Li
Jun
J
Li
Hong-chao
HC
D000293:Adolescent; D000328:Adult; D000368:Aged; D001845:Bone Cysts / Q000601:surgery; D001859:Bone Neoplasms / Q000601:surgery*; D001861:Bone Regeneration; D018786:Bone Substitutes; D002516:Ceramics; D002648:Child; D005260:Female; D005269:Femur / Q000601:surgery; D018212:Giant Cell Tumor of Bone / Q000601:surgery*; D006801:Humans; D006882:Hydroxyapatites; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants
D018786:Bone Substitutes; D006882:Hydroxyapatites; C119955:coralline hydroxyapatite