FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome.
The FTO (Fat mass and obesity associated) locus has recently been associated with obesity and type 2 diabetes (T2D) in humans. To understand the role of the FTO gene in polycystic ovary syndrome (PCOS) we genotyped single nucleotide polymorphism (SNP) rs1421085 (C/T) in women with PCOS (n=207) and controls (n=100) from a Central European population. The homozygous C/C genotype showed increased prevalence in PCOS patients either obese or with metabolic syndrome (MetS) compared to lean PCOS patients or controls (27.6%, 38.9%, 22.3%, and 16.3%, respectively). In logistic regression, this genotype strongly associated with MetS (P<0.0001, OR 3.2, 95% CI 1.8-5.7) and impaired fasting glucose (IFG) with P<0.0007, OR 7.7, 95% CI 2.1-28.6, independently of BMI or age, and to AUC(gluc) during OGTT (P<0.0001, alpha=0.99), indicating an influential role of the FTO gene in the glucose intolerance component of MetS.
Attaoua
Redha
R
Molecular Endocrinology Laboratory, IURC, 641 Avenue du Doyen Gaston Giraud, 34093 Montpellier Cedex 5, France.
Ait El Mkadem
Samira
S
Radian
Serban
S
Fica
Simona
S
Hanzu
Felicia
F
Albu
Alice
A
Gheorghiu
Monica
M
Coculescu
Mihai
M
Grigorescu
Florin
F
D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D016022:Case-Control Studies; D005215:Fasting; D005260:Female; D005838:Genotype; D005947:Glucose / Q000378:metabolism; D018149:Glucose Intolerance / Q000150:complications / Q000235:genetics; D006720:Homozygote; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications / Q000235:genetics*; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*
D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human; D005947:Glucose