Low levels of hepatitis C virus (HCV) neutralizing antibodies in patients coinfected with HCV and human immunodeficiency virus.
The hepatitis C virus (HCV) neutralizing antibody (nAb) response in 37 subjects with HCV monoinfection and 37 HCV-infected subjects with well-controlled human immunodeficiency virus (HIV) infection was evaluated using a focus reduction neutralization assay. HCV nAb levels were retrospectively studied in both groups of patients, who were matched on the basis of sex, age, and HCV genotype. The mean HCV nAb level (+/- standard deviation) among coinfected patients (1.613+/-0.416) was significantly less than that among monoinfected patients (1.912+/-0.578) (P= .013). Lower HCV nAb titers in coinfected patients could help worsen the outcome of HCV infection. These results favor starting HCV therapy as soon as possible in coinfected patients.
Castelain
Sandrine
S
Virologie, CHU-Hôpital Sud, Amiens, France.
Schnuriger
Aurélie
A
François
Catherine
C
Nguyen-Khac
Eric
E
Fournier
Carole
C
Schmit
Jean-Luc
JL
Capron
Dominique
D
Dubuisson
Jean
J
Wychowski
Czeslaw
C
Thibault
Vincent
V
Duverlie
Gilles
G
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006678:HIV / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications* / Q000276:immunology*; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000150:complications* / Q000276:immunology*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D012189:Retrospective Studies; D019562:Viral Load
D018937:Hepatitis C Antibodies