Comparative architecture of octahedral protein cages. I. Indexed enclosing forms.
The architectural elements of four protein cages (bacterio ferritin, human mitochondrial ferritin, sulfur oxygenase reductase and small heat-shock protein) are compared top-to-bottom. The starting points are polyhedra with octahedral symmetry 432 enclosing the cage and delimiting the central cavity, respectively, which have vertices at points of a species-dependent cubic form lattice. The approach is extended from the whole cage to axial-symmetric clusters down to polyhedral forms of single monomers viewed along the fourfold, the threefold and the twofold axes, respectively. The corresponding projected monomeric forms can be approximated by two-dimensional tiles, 13 enantiomorphic pairs in total. The determination of the cubic indices of the monomeric vertices opens the possibility of the way back analysis, bottom-to-top, as discussed in paper II [Janner (2008). Acta Cryst. A64, 503-512].
Janner
Aloysio
A
Theoretical Physics, Radboud University, Toernooiveld, NL-6525 ED Nijmegen, The Netherlands. a.janner@science.ru.nl
D041541:Acidianus / Q000737:chemistry; D000465:Algorithms; D003461:Crystallography; D045285:Desulfovibrio desulfuricans / Q000737:chemistry; D005293:Ferritins / Q000737:chemistry*; D006360:Heat-Shock Proteins / Q000737:chemistry*; D006801:Humans; D017017:Methanococcus / Q000737:chemistry; D008928:Mitochondria / Q000737:chemistry; D008958:Models, Molecular; D010088:Oxidoreductases / Q000737:chemistry*; D011487:Protein Conformation; D011994:Recombinant Proteins / Q000737:chemistry
D006360:Heat-Shock Proteins; D011994:Recombinant Proteins; D005293:Ferritins; D010088:Oxidoreductases