Fasting serum ghrelin level is associated with metabolic syndrome in peritoneal dialysis patients.
BACKGROUND
Serum ghrelin levels are elevated in uremic patients. However, no data are available on the relationship between metabolic syndrome and serum ghrelin levels in peritoneal dialysis (PD) patients.


METHODS
Metabolic syndrome and its components were defined using diagnostic criteria recommended by the International Diabetes Federation. Fasting serum samples were taken from 30 PD patients. Serum ghrelin levels were measured by using a commercial enzyme-linked immunosorbent assay kit.


RESULTS
Of the 30 PD patients, 53.3% (16/30) had metabolic syndrome. Fasting serum ghrelin corrected inversely with metabolic syndrome among these PDs patients (p = 0.002). By odds ratio (OR) analysis of metabolic syndrome and metabolic syndrome diagnostic criteria, the predictors for metabolic syndrome are fasting glucose [OR: 39.00; 95% confidence interval (CI): 3.80 to 399.85; p < 0.001], triglycerides (OR: 37.50; 95% CI: 3.64 to 386.51; p < 0.001), and waist circumference (OR: 4.20; 95% CI: 1.95 to 9.03; p < 0.001). Univariate linear regression analysis showed that body weight (r = -0.461, p = 0.010), waist circumference (r = -0.390, p = 0.033), and body mass index (r = -0.438, p = 0.016) were negatively correlated with serum ghrelin, and serum high density lipoprotein [HDL (r = 0.626, p < 0.001)] was positively correlated with serum ghrelin. Multivariate forward stepwise linear regression analysis of the significant variables showed that HDL (R(2) change = 0.392; p < 0.001) was the independent predictor of serum ghrelin in PD patients and explained 39.2% of the variance.


CONCLUSIONS
These results indicate an inverse association between circulating fasting ghrelin and metabolic syndrome in PD patients. Serum HDL was associated with serum ghrelin among PD patients.
Department of Nursing, Tzu Chi University, Hualien, Taiwan.
Chung-Jen
CJ
Lee
Yi-Maun
YM
Subeq
Chih-Hsien
CH
Wang
Ru-Ping
RP
Lee
Te-Chao
TC
Fang
Bang-Gee
BG
Hsu
D000368:Aged; D001786:Blood Glucose; D015992:Body Mass Index; D001835:Body Weight; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D010530:Peritoneal Dialysis; D011237:Predictive Value of Tests; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
D001786:Blood Glucose; D008076:Cholesterol, HDL; D054439:Ghrelin; D014280:Triglycerides