A description of genes of Corynebacterium pseudotuberculosis useful in diagnostics and vaccine applications.
Corynebacterium pseudotuberculosis, a Gram-positive intracellular pathogen, is the etiological agent of caseous lymphadenitis or CLA. This bacterium infects goats and sheep and causes great economic losses worldwide annually, mainly for goat producers. Despite its importance, CLA is still poorly characterized. However, with advances in the genomic field, many C. pseudotuberculosis genes have already been characterized, mainly those related to virulence such as phospholipase D. Here, we examined the use of the several available genes of C. pseudotuberculosis and reviewed their applications in vaccine construction, more efficient diagnostics for CLA, and control of this disease, among other applications.
Laboratório de Genética Celular e Molecular, Departamento de Biologia Geral, ICB-UFMG, Belo Horizonte, MG, Brasil.
V
V
D'Afonseca
P M
PM
Moraes
F A
FA
Dorella
L G C
LG
Pacheco
R
R
Meyer
R W
RW
Portela
A
A
Miyoshi
V
V
Azevedo
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics* / Q000276:immunology; D001428:Bacterial Vaccines / Q000235:genetics / Q000276:immunology; D003354:Corynebacterium Infections / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology; D016925:Corynebacterium pseudotuberculosis / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity; D008199:Lymphadenitis / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins; D001428:Bacterial Vaccines