Iridium-catalyzed enantioselective hydrogenation of alpha,beta-unsaturated carboxylic acids.
A highly efficient iridium-catalyzed hydrogenation of alpha,beta-unsaturated carboxylic acids has been developed by using chiral spiro-phosphino-oxazoline ligands, affording alpha-substituted chiral carboxylic acids in exceptionally high enantioselectivities and reactivities.
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
Shen
S
Li
Shou-Fei
SF
Zhu
Can-Ming
CM
Zhang
Song
S
Song
Qi-Lin
QL
Zhou