Visual information processing in recently abstaining methamphetamine-dependent individuals: evoked potentials study.
OBJECTIVE
Methamphetamine (MAP) is an indirect dopamine agonist that can temporarily increase cognitive performance. However, its long-term abuse may cause dopamine depletion and consequent cognitive and attentional impairment. The worsening of visual functions in Parkinson's disease and their improvement after levodopa administration implicates the role of dopamine in the physiology of vision. This provides the rationale for the investigation of visual functions in abstaining MAP abusers.


METHODS
We investigated changes in visually evoked potentials (VEPs) to pattern-reversal and motion-onset stimuli. Such changes serve as indices of visual information processing in the primary and associative areas in a group of recently abstaining MAP abusers (5 females, 18 males, MAP abuse 5.3 +/- 2.8 years) and in 23 age- and gender-paired controls.


RESULTS
We did not find differences between the groups in visual acuity. In the group of MAP abusers we observed an attenuation of the early responses around 80 ms and a prolongation of the P1 peak latency after the reversal of high spatial frequency checkerboards (10 and 20 arcmin checks). Furthermore, an attenuation of the latter positive response (170-250 ms) was observed among all the stimuli in parieto-frontal derivations for the MAP abusers.


CONCLUSIONS
This is the first report suggesting a slowing and attenuation of VEP responses during visual processing in abstaining methamphetamine abusers.
Department of Pathological Physiology, Faculty of Medicine in Hradec Králové, Charles University in Prague, Simkova 870, 500 38, Hradec Králové, Czech Republic. jan.kremlacek@lfhk.cuni.cz
Jan
J
Kremlácek
Ladislav
L
Hosák
Miroslav
M
Kuba
Jan
J
Libiger
Jirí
J
Cízek
D000328:Adult; D019969:Amphetamine-Related Disorders / Q000503:physiopathology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects; D009039:Motion Perception / Q000502:physiology*; D014795:Visual Pathways / Q000503:physiopathology*; D055815:Young Adult
D008694:Methamphetamine