Chaperonin 60 and macrophage activation.
Eukaryotic and prokaryotic chaperonin 60s (Cpn60s) activate macrophages to produce pro-inflammatory cytokines. CD14 and TLR4 have been proposed as potential Cpn receptors. In addition, Cpn60s can block LPS-induced activation. This is a dose-related effect, low concentrations block, and high concentrations activate. This may relate to the ability of Cpn60s to block inflammatory disease. Cpns are multiplex or moon-lighting proteins, with functions as molecular chaperones, in stress survival and as inflammatory modulators. A cpn60.1 knockout mutant does not induce a granulomatous response and cytokine levels, such as tumour necrosis factor are reduced in the tissues. These data suggest that Cpn60.1 may also function as a virulence factor.
Medical Microbiology, Centre for Infection, Department of Cellular and Molecular Medicine, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
Anthony R M
AR
Coates
Ana
A
Cehovin
Yanmin
Y
Hu
D018834:Chaperonin 60 / Q000276:immunology*; D006099:Granuloma / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology; D007165:Immunosuppression Therapy; D008262:Macrophage Activation / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology
D018834:Chaperonin 60; D007155:Immunologic Factors; D011956:Receptors, Cell Surface