An Iranian herbal-marine medicine, MS14, ameliorates experimental allergic encephalomyelitis.
Multiple sclerosis is an inflammatory and demyelinating disease of the central nervous system which mainly affects young adults. To overcome wide spectrum troublesome symptoms of multiple sclerosis which affects the quality of life both in patients and their families, new drugs and remedies have been examined and offered. The preclinical beneficial effects of different medicines have mostly been examined in an animal model of multiple sclerosis called experimental allergic encephalomyelitis (EAE). In this study we have tested a traditionally used natural (herbal-marine) product called MS(14) in EAE mice. EAE mice were fed with MS(14) containing diet (30%) on the immunization day and monitored for 20 days. The results show that while clinical scores and therefore severity of the disease was progressive in normal-fed EAE mice, the disease was slowed down in MS(14)-fed EAE mice. Moreover, while there were moderate to severe neuropathological changes in normal fed mice, milder changes were seen in MS(14) fed mice.
National Research Institute for Genetic Engineering and Biotechnology, Tehran, Iran. aptafreshi@yahoo.com
Azita Parvaneh
AP
Tafreshi
Amrollah
A
Ahmadi
Majid
M
Ghaffarpur
Hossein
H
Mostafavi
Hossein
H
Rezaeizadeh
Bagher
B
Minaie
Soghrat
S
Faghihzadeh
Mohsen
M
Naseri
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D000077102:Apium / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D003711:Demyelinating Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D018450:Disease Progression; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D020902:Hypericum / Q000502:physiology; D020300:Intracranial Hemorrhages / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D007492:Iran; D051379:Mice; D009336:Necrosis; D033561:Penaeidae / Q000737:chemistry
D001688:Biological Products