[Polymorphism of glutathion-S-transferase genes in patients with prostatic cancer].
The study of polymorphic variants of GSTT1, GSTM1 and GSTP1 genes from 61 patients with prostatic cancer (PC) has shown that incidence of 0/0 genotype GSTT1 and GSTM1 in PC patients was significantly higher of that in healthy men (n = 100) (34.4 and 15% in p = 0.007 and 60.7 and 43% in p = 0.04, respectively). PC risk in carriers of a GSTT1 deletion form was 2.97, CI95%--1.3-6.84, GSTM1--2.04 in CI95% 1.02-4.1. The analysis of combinations of pathological genotypes of xenobiotic biotransformation enzymes has demonstrated that 89.8% PC patients have a mutation in one of the genes GSTT1, GSTM1 or GSTP1.
Davydova
N A
NA
Dmitrieva
A I
AI
Selivanov
S P
SP
Tkachenko
S B
SB
Kovalik
T A
TA
Kolomiets
S A
SA
Sevast'ianova
N V
NV
Novitskiĭ
V V
VV
D000368:Aged; D000369:Aged, 80 and over; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics* / Q000378:metabolism; D005982:Glutathione Transferase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000235:genetics*
D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D009363:Neoplasm Proteins; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human