Calcium intake and the 10-year incidence of self-reported vertebral fractures in women and men: the Japan Public Health Centre-based Prospective Study.
The purpose of this study was to evaluate the effect of low Ca intake on the 10-year incidence of vertebral fractures in cohorts I and II of the Japan Public Health Centre-based Prospective Study. The baseline studies were conducted in 1990-1994, with the follow-up studies conducted after 10 years. We analysed 33,970 subjects aged 40-59 years in cohort I and 41,664 subjects aged 40-69 years in cohort II. At baseline, the intake of Ca was assessed as a predictor, using validated FFQ. A meta-analysis was performed to estimate a summary relative risk (RR) for the two cohort studies. The 10-year cumulative incidences of self-reported vertebral fractures were 0.38% for cohort I and 0.56% for cohort II. In women, lower Ca intake was associated with a higher incidence of vertebral fractures (P for trend=0.001), with the lowest quartile of Ca intake having a significantly higher incidence (0.89/1000 persons per year or RR 2.10 (95% CI 1.25, 3.55)) than that (0.42/1000 persons per year) of the highest. In addition, the RR calculated using energy-adjusted Ca intake (by the residual method) as an outcome was 1.92 (95% CI 1.28, 2.88). However, no such association was observed in men. An increase of Ca intake should be considered as a preventive strategy for vertebral fractures in peri- and post-menopausal women with a low Ca intake.
Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan. kazun@med.niigata-u.ac.jp
Kazutoshi
K
Nakamura
Norie
N
Kurahashi
Junko
J
Ishihara
Manami
M
Inoue
Shoichiro
S
Tsugane
D000328:Adult; D000368:Aged; D002136:Calcium, Dietary / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017698:Postmenopause; D011446:Prospective Studies; D012306:Risk; D016103:Spinal Fractures / Q000453:epidemiology*; D011795:Surveys and Questionnaires
D002136:Calcium, Dietary