Chemical exchange saturation transfer by intermolecular double-quantum coherence.
A number of contrast enhancement effects based on the use of intermolecular multiple-quantum coherences, or distant dipolar field effects are known. This phenomenon is characterized by the dependence on the mth power of the initial magnetization (where m is the coherence order used). In this paper, we describe the contrast enhancement based on chemical exchange saturation transfer and NOE, which is achieved by the use of intermolecular double-quantum coherences (iDQC). The method was validated using clinically relevant systems based on glycosaminoglycans and a sample of cartilage tissue, showing that the CEST contrast, as well as, NOE are enhanced by iDQC.
Chemistry Department, New York University, New York, NY 10003, USA.
Wen
W
Ling
Uzi
U
Eliav
Gil
G
Navon
Alexej
A
Jerschow
D000465:Algorithms; D000818:Animals; D002358:Cartilage, Articular / Q000033:anatomy & histology* / Q000378:metabolism*; D002417:Cattle; D006025:Glycosaminoglycans / Q000032:analysis*; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011789:Quantum Theory; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D006025:Glycosaminoglycans