Does calcium channel blocker improvement of perfusion impact the functioning of kidney graft in early period after transplantation?
The aim of the study was to evaluate the influence of reduced vascular resistance following calcium channel blocker verapamil administration on kidney function at 3 months after transplantation. A group of 48 kidneys received 100 microg verapamil by injection directly into renal artery before starting perfusion. The control group included 48 paired kidneys without verapamil addition. Calcium channel blocker therapy with verapamil greatly decreased renal vascular resistance but it did not affect graft function. Administration of calcium channel blockers improved kidney function in the early period after transplantation. A better-functioning graft seems to be based more on metabolic than hemodynamic effects.
Nowacki
M
M
Department of Surgery and Transplantation Pomeranian University of Medicine, Szczecin, Poland. m.nowacki.md@gmail.com
Droździk
M
M
Safranow
K
K
Kaminski
M
M
Sulikowski
T
T
Zietek
Z
Z
Romanowski
M
M
Sienko
J
J
Mizerski
A
A
Ignaczak
E
E
Domanski
L
L
Pabisiak
K
K
Bohatyrewicz
R
R
Ostrowski
M
M
D002102:Cadaver; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D004231:Diuresis / Q000187:drug effects / Q000502:physiology; D005500:Follow-Up Studies; D006801:Humans; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000502:physiology*; D012079:Renal Circulation / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D014019:Tissue Donors; D014508:Urea / Q000097:blood; D014655:Vascular Resistance / Q000187:drug effects*; D014700:Verapamil / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D014508:Urea; D003404:Creatinine; D014700:Verapamil