A novel application of plasma and cerebrospinal fluid level of epstein barr virus DNA in the diagnosis of leptomeningeal metastasis from nasopharyngeal carcinoma. A case report.
Epstein Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) is endemic in Southeast Asia, and the plasma level of EBV DNA is a highly sensitive marker of disease recurrence following radiotherapy. Leptomeningeal recurrence from NPC is extremely rare and difficult to diagnose; only 4 cases have been reported in the literature. We report a case of leptomeningeal recurrence in NPC that was diagnosed using imaging and plasma and cerebrospinal fluid EBV DNA assays, followed by a review of the literature.
Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR, China. a_ma@clo.cuhk.edu.hk
Ada T W
AT
Ma
Brigette B Y
BB
Ma
Peter M L
PM
Teo
Anthony T C
AT
Chan
D000328:Adult; D004279:DNA, Viral / Q000097:blood* / Q000134:cerebrospinal fluid*; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000821:virology*; D009303:Nasopharyngeal Neoplasms / Q000473:pathology* / Q000821:virology*
D004279:DNA, Viral