The impact of new-onset diabetes on arterial stiffness after renal transplantation.
New-onset diabetes after renal transplantation (NODAT) is known to be a potent risk factor for cardiovascular events. We therefore investigated the incidence and risk factors for NODAT, and evaluated surrogate endpoints of atherosclerosis in Japanese patients with stable renal function after renal transplantation. Seventy-nine patients were enrolled in the study, and a 75 g oral glucose tolerance test (OGTT) was performed in subjects excluding patients with known NODAT. We evaluated the risk factors for NODAT and the degree of atherosclerosis, determined by brachial-ankle pulse wave velocity (baPWV), ankle-brachial blood pressure index (ABPI) and intima-media thickness (IMT) of the carotid artery. Eleven patients diagnosed as NODAT had significantly higher fasting plasma glucose before transplantation, blood pressure, and incidence of hepatitis C virus (HCV) infection than patients without NODAT. Multivariate regression analysis revealed that the independent determinant of NODAT was fasting plasma glucose pre-transplantation, HCV infection and systolic blood pressure. The baPWV in patients with NODAT was significantly higher compared to that in patients without NODAT. In addition, the independent determinant of baPWV evaluated by multivariate regression analysis was an increase in systolic blood pressure and age, and a decrease of adiponectin levels. In conclusion, we found that high fasting plasma glucose prior to transplantation, HCV infection and high blood pressure are risk factors for NODAT in Japanese patients after renal transplantation. Since NODAT patients have advanced arterial stiffness probably due to high blood pressure, strict control of blood pressure will be important for preventing the development of cardiovascular disease in NODAT.
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Japan.
Ken
K
Kato
Munehide
M
Matsuhisa
Naotsugu
N
Ichimaru
Shiro
S
Takahara
Yasuyuki
Y
Kojima
Kaoru
K
Yamamoto
Toshihiko
T
Shiraiwa
Akio
A
Kuroda
Naoto
N
Katakami
Ken'ya
K
Sakamoto
Taka-aki
TA
Matsuoka
Hideaki
H
Kaneto
Yoshimitsu
Y
Yamasaki
Masatsugu
M
Hori
D000328:Adult; D000842:Ankle; D050197:Atherosclerosis / Q000209:etiology; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004548:Elasticity; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012307:Risk Factors; D017540:Tunica Media / Q000473:pathology; D014655:Vascular Resistance