Virilizing ovarian tumor in a 14-year-old female with a prior familial multinodular goiter.
A 14-year-old female presented with intermittent abdominal pain, deepening of voice and amenorrhoea for 4 months. Twelve months earlier she had had a thyroidectomy because of familial multinodular goiter and had, subsequently, received substitution with L-thyroxine. At the time of admission, a high serum testosterone level was detected. The dexamethasone suppression test confirmed the hormonal autonomy and magnetic resonance imaging (MRI) visualized a solid tumor within the left ovary. The pathological diagnosis after left salpingo-oophorectomy was Sertoli-Leydig cell tumor. The patient has remained disease-free for 6 years.
Department of Pediatric Endocrinology and Diabetes, 2nd Chair of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland. mniedzie@ump.edu.pl
Marek
M
Niedziela
D000293:Adolescent; D005260:Female; D006042:Goiter / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D010052:Ovariectomy; D013965:Thyroidectomy; D014770:Virilism / Q000473:pathology*