A randomized, placebo-controlled trial of the effects of physical exercises and estrogen therapy on health-related quality of life in postmenopausal women.
OBJECTIVE
The purpose of this study was to evaluate the isolated and associated effects of estrogen therapy (estradiol valerate 1 mg/d orally) and physical exercise (moderate aerobic exercise, 3 h/wk) on health-related quality of life (HRQOL) and menopausal symptoms among women who had undergone hysterectomy.


METHODS
A 6-month, randomized, double-blind, placebo-controlled clinical trial with 44 postmenopausal women who had undergone hysterectomy. The interventions were physical exercise and hormone therapy (n = 9), being sedentary and hormone therapy (n = 14), physical exercise and placebo (n = 11), and being sedentary and placebo (n = 10). HRQOL was assessed by a Brazilian standard version of the Medical Outcome Study Short-Form Health Survey and symptoms by Kupperman Index at baseline and after 6 months.


RESULTS
There was a decrease in symptoms in all groups, but only groups who performed physical exercise showed an increase in quality of life. Analysis of variance showed that changes in physical functioning (P = 0.001) and bodily pain (P = 0.012) scores over the 6-month period differed significantly between women who exercised and women who were sedentary, regardless of hormone therapy. Hormone therapy had no effect, and there was also no significant association between physical exercise and hormone therapy in HRQOL.


CONCLUSIONS
Physical exercises can reduce menopausal symptoms and enhance HRQOL, independent of whether hormone therapy is taken.
Moriyama
Carolina Kimie
CK
Hypertension Unit, General Hospital, Sao Paulo, Brazil. ck.moriyama@uol.com.br
Oneda
Bruna
B
Bernardo
Fernanda Rocchi
FR
Cardoso
Crivaldo Gomes
CG
Forjaz
Claudia L M
CL
Abrahao
Sandra B
SB
Mion
Décio
D
Fonseca
Angela M
AM
Tinucci
Tais
T
D004311:Double-Blind Method; D015914:Estrogen Replacement Therapy; D015444:Exercise; D005260:Female; D006304:Health Status; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D017698:Postmenopause; D011788:Quality of Life