Photocytotoxicity of platinum(IV)-chloride surface modified TiO2 irradiated with visible light against murine macrophages.
Phototoxicity of titanium dioxide modified with platinum(IV)-chloride complexes, [TiO2/PtCl4], irradiated with visible light was tested on murine macrophage cell line (RAW 264.7) in vitro. Presence of antioxidants such as alpha-tocopherol or beta-carotene during photodynamic treatment significantly increased cells viability. Our results indicate that observed cell death induced by [TiO2/PtCl4] was due to photogeneration of reactive species.
Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.
Agnieszka
A
Jańczyk
Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-349 Kraków, Poland.
Agnieszka
A
Wolnicka-Głubisz
Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-349 Kraków, Poland.
Krystyna
K
Urbanska
Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.
Grażyna
G
Stochel
Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.
Wojciech
W
Macyk
D000818:Animals; D002460:Cell Line; D008027:Light; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D051379:Mice; D010777:Photochemistry; D017671:Platinum Compounds / Q000494:pharmacology*; D014025:Titanium / Q000494:pharmacology*; D024502:alpha-Tocopherol / Q000378:metabolism*; D019207:beta Carotene / Q000378:metabolism*
D017671:Platinum Compounds; D019207:beta Carotene; C009495:titanium dioxide; D014025:Titanium; D024502:alpha-Tocopherol; C032741:platinum tetrachloride