Pharmacokinetics and tissue distribution of piperine lipid nanospheres.
The purpose of this study was to estimate the pharmacokinetic parameters and tissue distribution of positively charged stearylamine (LN-P-SA) and pegylated lipid nanospheres (LN-P-PEG) of piperine in BALB/c mice. Lipid nanospheres of piperine (LN-P), LN-P-PEG and LN-P-SA were prepared by homogenization followed by ultrasonication. The pharmacokinetics and tissue distribution of different lipid nanosphere formulations (piperine, LN-P, LN-P-PEG and LN-P-SA) were studied in male BALB/c mice. The pharmacokinetic parameters of LN-P-PEG and LN-P-SA were: AUC(0-24): 372.1 +/- 71.6 and 162.2 +/- 36.4 microg h(-1) ml(-1), clearance 13 +/- 2.5 and 32 +/- 7.5 ml h(-1), Cmax: 24.7 +/- 1.5 and 22.3 +/- 1.0 microg ml(-1), Vd: 0.45 +/- 0.02 and 0.66 +/- 0.06 l Kg(-1)). Pharmacokinetics of piperine in lipid nanospheres showed a biexponential decline with significantly high AUC, a lower rate of clearance and a smaller volume of distribution than piperine.
University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India. vpreddyindia@yahoo.com
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Veerareddy
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Vobalaboina
D000470:Alkaloids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000588:Amines; D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D052117:Benzodioxoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001923:Brain Chemistry / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004337:Drug Carriers; D008055:Lipids; D051379:Mice; D008807:Mice, Inbred BALB C; D054118:Nanospheres; D010880:Piperidines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011092:Polyethylene Glycols / Q000737:chemistry; D053284:Polyunsaturated Alkamides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013056:Spectrophotometry, Ultraviolet; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D014018:Tissue Distribution
D000470:Alkaloids; D000588:Amines; D000977:Antiparasitic Agents; D052117:Benzodioxoles; D004337:Drug Carriers; D008055:Lipids; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D011092:Polyethylene Glycols; C009317:stearylamine; C008922:piperine