Ritonavir-boosted atazanavir, methadone, and ventricular tachycardia: 2 case reports.
We describe 2 cases of symptomatic ventricular tachycardia associated with prolonged QT interval. Both patients were infected with the human immunodeficiency virus and were receiving treatment with ritonavir-boosted atazanavir and methadone. Discontinuation of atazanavir in both cases resulted in a reduction in the QT interval and cessation of arrhythmia. We concluded that atazanavir contributed to prolonged corrected QT interval and subsequent ventricular tachycardia.
Gallagher
David P
DP
Department of 1Infectious Diseases, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland. davgallagher@gmail.com
Kieran
Jennifer
J
Sheehan
Gerard
G
Lambert
John
J
Mahon
Niall
N
Mallon
Patrick W G
PW
D000328:Adult; D000069446:Atazanavir Sulfate; D004359:Drug Therapy, Combination; D004562:Electrocardiography / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D008875:Middle Aged; D009294:Narcotics / Q000627:therapeutic use; D009842:Oligopeptides / Q000009:adverse effects*; D011725:Pyridines / Q000009:adverse effects*; D019438:Ritonavir / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000139:chemically induced*
D017320:HIV Protease Inhibitors; D009294:Narcotics; D009842:Oligopeptides; D011725:Pyridines; D000069446:Atazanavir Sulfate; D019438:Ritonavir; D008691:Methadone