Diversity-oriented synthesis.
Diversity-oriented synthesis (DOS), which describes the synthesis of structurally diverse collections of small molecules, was developed, in part, to address combinatorial chemistry's shortfalls. In this paper, we hope to give an indication of what can be achieved using the DOS approach to library generation. We describe some of the most successful strategies utilized in DOS, with special focus on our own area of interest; DOS from simple, pluripotent starting materials.
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
Richard J
RJ
Spandl
Mónica
M
Díaz-Gavilán
Kieron M G
KM
O'Connell
Gemma L
GL
Thomas
David R
DR
Spring
D002625:Chemistry, Organic / Q000379:methods* / Q000639:trends; D002626:Chemistry, Pharmaceutical / Q000379:methods* / Q000639:trends; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*
D004364:Pharmaceutical Preparations