Cell type-specific firing during ripple oscillations in the hippocampal formation of humans.
High-frequency field ripples occur in the rodent hippocampal formation and are assumed to depend on interneuron type-specific firing patterns, structuring the activity of pyramidal cells. Ripples with similar characteristics are also present in humans, yet their underlying cellular correlates are still unknown. By in vivo recording interneurons and pyramidal cells in the human hippocampal formation, we find that cell type-specific firing patterns and phase-locking on a millisecond timescale can be distinguished during ripples. In particular, pyramidal cells fired preferentially at the highest amplitude of the ripple, but interneurons began to discharge earlier than pyramidal cells. Furthermore, a large fraction of cells were phase-locked to the ripple cycle, but the preferred phase of discharge of interneurons followed the maximum discharge probability of pyramidal neurons. These relationships between human ripples and unit activity are qualitatively similar to that observed in vivo in the rodents, suggesting that their underlying mechanisms are similar.
Centre National de la Recherche Scientifique, Cognitive Neuroscience and Brain Imaging Laboratory, Unité Propre de Recherche 640, Hôpital de la Pitié-Salpêtrière, 75651 Paris, France. lenalm@ext.jussieu.fr
Michel
M
Le Van Quyen
Anatol
A
Bragin
Richard
R
Staba
Benoit
B
Crépon
Charles L
CL
Wilson
Jerome
J
Engel
D000200:Action Potentials / Q000502:physiology*; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000473:pathology; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000145:classification / Q000502:physiology*; D010507:Periodicity