Optimal band imaging system: a new tool for enhancing the duodenal villous pattern in celiac disease.
BACKGROUND
The optimal band imaging (OBI) system is a new technology that can select better spectral images decomposed from ordinary endoscopic images. This technology, first introduced as "FUJI Intelligent Color Enhancement," enhances the contrast of the mucosal surface without the use of dyes.


OBJECTIVE
This study aimed to evaluate the potential of OBI for predicting the duodenal villous morphologic characteristics in patients with suspected celiac disease.


METHODS
This study was designed as an open, prospective, single-center trial. Duodenoscopy was performed with a high-resolution magnification view, in association with OBI spectral processing. Duodenal villous patterns were evaluated and classified as normal, partially atrophic, or markedly atrophic. The endoscopic results were then compared with the histologic diagnosis.


METHODS
Endoscopy unit at the A. Gemelli University Hospital of Rome, Italy.


METHODS
Sixty-one patients undergoing upper endoscopy for clinical history of malabsorption or serologic suspicion for celiac disease were included in the study.


RESULTS
From OBI sets using red, green, and blue wavelength combinations that ranged from 400 to 580 nm, the endoscopist was able to find marked villous atrophy of the duodenum in 16 subjects, partial villous atrophy in 9 subjects, and normal villi in the remaining 36 subjects. The sensitivity, specificity, and positive and negative predictive values of the OBI-based duodenoscopy were 100% accurate in the evaluation of villous patterns.


CONCLUSIONS
High-resolution magnification endoscopy with OBI allows clear visualization of the duodenal villous pattern. The OBI system may play a potential role in optimizing the diagnostic accuracy of endoscopy in celiac disease.
Cammarota
Giovanni
G
Department of Internal Medicine, Endoscopy Unit, Catholic University of Medicine and Surgery, Rome, Italy.
Cesaro
Paola
P
Cazzato
Alessia
A
Fedeli
Paolo
P
Sparano
Lucia
L
Vecchio
Fabio M
FM
Larocca
Luigi M
LM
Gasbarrini
Giovanni
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D001284:Atrophy / Q000473:pathology; D001707:Biopsy, Needle; D002446:Celiac Disease / Q000175:diagnosis / Q000473:pathology*; D004396:Coloring Agents; D003287:Contrast Media / Q000494:pharmacology; D020698:Duodenoscopes; D004384:Duodenoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D008871:Microvilli / Q000473:pathology / Q000648:ultrastructure; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity
D004396:Coloring Agents; D003287:Contrast Media