Hydrochalarones: a novel endohedral metallofullerene platform for enhancing magnetic resonance imaging contrast.
Targeted imaging requires contrast agents that remain in the vasculature for extended periods of time. A new contrast agent is described in which gadolinium is encapsulated within an extremely stable carbon sphere, thus allowing for safe extended residence. Water solubility and small particle size is achieved with novel fullerene chemistry, attaching multiple oligoethylene glycol groups through nitrogen chemistry. These new compounds can be used to visualize tissue architecture in vivo with standard MRI techniques.
MacFarland
Darren K
DK
Luna nanoWorks (A Division of Luna Innovations, Incorporated), 521 Bridge Street, Danville, Virginia 24541, USA. macfarlandd@lunainnovations.com
Walker
Kenneth L
KL
Lenk
Robert P
RP
Wilson
Stephen R
SR
Kumar
Krishan
K
Kepley
Christopher L
CL
Garbow
Joel R
JR
D000818:Animals; D003287:Contrast Media / Q000737:chemistry* / Q000494:pharmacology*; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology*; D005682:Gadolinium / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D009928:Organ Specificity / Q000187:drug effects
D003287:Contrast Media; D037741:Fullerenes; D005682:Gadolinium