Emerging roles of DMP1 in lung cancer.
The Ras-activated transcription factor DMP1 can stimulate Arf transcription to promote p53-dependent cell arrest. One recent study deepens the pathophysiologic significance of this pathway in cancer, first, by identifying DMP1 losses in human lung cancers that lack ARF/p53 mutations, and second, by demonstrating that Dmp1 deletions in the mouse are sufficient to promote K-ras-induced lung tumorigenesis via mechanisms consistent with a disruption of Arf/p53 suppressor function. These findings prompt further investigations of the prognostic value of DMP1 alterations in human cancers and the oncogenic events that can cooperate with DMP1 inactivation to drive tumorigenesis.
Inoue
Kazushi
K
Departments of Pathology and Cancer Biology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, North Carolina, USA. kinoue@wfubmc.edu
Sugiyama
Takayuki
T
Taneja
Pankaj
P
Morgan
Rachel L
RL
Frazier
Donna P
DP
D000818:Animals; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D010750:Phosphoproteins / Q000502:physiology*; D015398:Signal Transduction; D018631:ras Proteins / Q000502:physiology
C513309:DMP1 protein, human; C513308:Dmp1 protein, mouse; D016326:Extracellular Matrix Proteins; D010750:Phosphoproteins; D018631:ras Proteins