Autoantibodies against complement C1q in acute post-streptococcal glomerulonephritis.
Autoantibodies against complement C1q (anti-C1q) strongly correlate with the occurrence of severe lupus nephritis. Recent data suggest that anti-C1q might also correlate with more severe forms of acute post-streptococcal glomerulonephritis (APSGN). Therefore, we prospectively investigated the role of anti-C1q in 50 children with newly diagnosed APSGN. Associations between anti-C1q and disease manifestations as well as serum complement concentrations were analyzed. Nineteen of the 50 children (38%) with APSGN were positive for anti-C1q compared to 0/40 healthy controls. Levels of anti-C1q correlated negatively with serum C1q and C3 concentrations. Anti-C1q positive patients had significantly higher proteinuria and serum creatinine as well as more often oliguria, hypertension and delayed resolution of the disease than patients without anti-C1q. The data point to a potential pathogenic role of anti-C1q in APSGN. Determination of anti-C1q might help to identify patients at risk for prolonged courses of the disease.
Department of Pediatrics, 2nd Children's Hospital, Belarus State University, Minsk, Belarus.
Ina
I
Kozyro
Ludmila
L
Korosteleva
Dmitryj
D
Chernoshej
Doris
D
Danner
Alexander
A
Sukalo
Marten
M
Trendelenburg
D000208:Acute Disease; D000293:Adolescent; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D015922:Complement C1q / Q000032:analysis / Q000276:immunology*; D003176:Complement C3 / Q000032:analysis / Q000276:immunology; D003181:Complement C4 / Q000032:analysis / Q000276:immunology; D003404:Creatinine / Q000097:blood; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008297:Male; D011507:Proteinuria / Q000276:immunology / Q000378:metabolism; D013290:Streptococcal Infections / Q000150:complications*
D001323:Autoantibodies; D003176:Complement C3; D003181:Complement C4; D015922:Complement C1q; D003404:Creatinine