The antimicrobial sensitivity of Streptococcus mutans to nanoparticles of silver, zinc oxide, and gold.
Dental caries is a worldwide public health problem for which Streptococcus mutans has been identified as the possible infectious etiology. In recent years nanotechnology has permitted the development of new properties of materials. The objective of this study was to compare the bactericidal and bacteriostatic effects of nanoparticles of silver, zinc oxide, and gold on S. mutans. We used the liquid dilution method to find the minimum inhibitory concentrations (MICs) and with subcultures obtained the minimum bactericidal concentrations (MBCs). For silver the results showed an average MIC of 4.86 +/- 2.71 microg/mL and MBC of 6.25 microg/mL; for zinc the MIC was 500 +/- 306.18 muicrog/mL and MBC of 500 microg/mL; the gold nanoparticles demonstrated an effect only at an initial concentration of 197 mug/mL. We established a higher antimicrobial effect against S. mutans of silver nanoparticles at lower concentrations than gold or zinc, which would allow achieving important clinical effects with a reduced toxicity.
Clinical Epidemiology, Faculty of Medicine, Universidad Autónoma de San Luís Potosí, San Luis Potosí, Mexico. fsierra@uaslp.mx
Juan Francisco
JF
Hernández-Sierra
Facundo
F
Ruiz
Diana Corina Cruz
DC
Pena
Fidel
F
Martínez-Gutiérrez
Alberto Emilio
AE
Martínez
Amaury de Jesús Pozos
Ade J
Guillén
Humberto
H
Tapia-Pérez
Gabriel Martínez
GM
Castañón
D000890:Anti-Infective Agents / Q000494:pharmacology*; D006046:Gold / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles; D012834:Silver / Q000494:pharmacology*; D013295:Streptococcus mutans / Q000187:drug effects*; D015034:Zinc Oxide / Q000494:pharmacology*
D000890:Anti-Infective Agents; D012834:Silver; D006046:Gold; D015034:Zinc Oxide