Directions in QSAR modeling for regulatory uses in OECD member countries, EU and in Russia.
The aim of this article is to show the main aspects of quantitative structure activity relationship (QSAR) modeling for regulatory purposes. We try to answer the question; what makes QSAR models suitable for regulatory uses. The article focuses on directions in QSAR modeling in European Union (EU) and Russia. Difficulties in validation models have been discussed.
National Institute of Chemistry, Ljubljana, Slovenia. natalja.fjodorova@ki.si
Natalja
N
Fjodorova
Marjana
M
Novich
Marjan
M
Vrachko
Vjacheslav
V
Smirnov
Nina
N
Kharchevnikova
Zoya
Z
Zholdakova
Sergei
S
Novikov
Natalja
N
Skvortsova
Dmitrii
D
Filimonov
Vladimir
V
Poroikov
Emilio
E
Benfenati
D032761:Animal Experimentation; D023401:Animal Use Alternatives; D000818:Animals; D005060:Europe; D015386:Hazardous Substances / Q000145:classification / Q000633:toxicity*; D006801:Humans; D008954:Models, Biological; D011237:Predictive Value of Tests; D011356:Product Labeling; D011640:Public Policy; D021281:Quantitative Structure-Activity Relationship; D018570:Risk Assessment; D012426:Russia; D018675:Toxicity Tests
D015386:Hazardous Substances