Insight into the mechanism of the acquired antibody auto-reactivity.
A fraction of antibodies present in all healthy individuals begins to recognize large number of self-antigens only after a transient exposure to certain protein-destabilizing conditions, including low or high pH, high salt concentration, chaotropic factors and redox-active agents. Recent findings on the molecular mechanisms of the inducible antibody auto-reactivity, obtained by using kinetic and thermodynamic analysis on the interactions of single monoclonal antibody with its cognate antigen are discussed in the review.
Dimitrov
Jordan D
JD
Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Paris 6, UMRS 872, Paris, F-75006 France. Jordan.Dimitrov@crc.jussieu.fr
Lacroix-Desmazes
Sebastien
S
Kaveri
Srinivas V
SV
Vassilev
Tchavdar L
TL
D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D001323:Autoantibodies / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007700:Kinetics; D013816:Thermodynamics
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D007074:Immunoglobulin G