Menstrual cycle and bone health in adolescents.
The intriguing notion of the menstrual cycle's having an acute impact on bone metabolism is examined as an expression of estrogen changes manifest as fluctuations in calcium-regulating hormones or biomarkers of bone formation/resorption. The effects of estrogen, progesterone, androgens, and follicle-stimulating hormones on bone health are also reviewed here. To date, the balance of evidence suggests that the menstrual cycle may exert a significant effect on bone metabolism. Further research needs to be conducted, however, to define these hormonal relationships.
Division of Adolescent Medicine, Department of Pediatrics, Case Western Reserve University School of Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA. bcromer@metrohealth.org
Barbara A
BA
Cromer
D000293:Adolescent; D000728:Androgens / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology*; D011374:Progesterone / Q000378:metabolism
D000728:Androgens; D015415:Biomarkers; D004967:Estrogens; D011374:Progesterone; D005640:Follicle Stimulating Hormone