A single nucleotide polymorphism at chromosome 2q21.3 (LCT -13910C>T) associates with clinical outcome after allogeneic hematopoietic stem cell transplantation.
A single nucleotide polymorphism (SNP) responsible for lactase persistence (LCT -13910C>T) changes intestinal microflora. Considering the influence of bacterial microflora on various immune effects, we tested DNA from 111 recipients/donors and analyzed whether this SNP interferes with survival and the incidence of acute graft-versus-host disease (aGVHD) after allogeneic hematopoetic stem cell transplantations (HSCT). Median overall survival (OS) was significantly longer when donors had a CC genotype (not reached after 133 vs 11.1 months, P = .004). Multivariate analysis identified a donor T allele (hazard ratio 2.63, 95% confidence interval 1.29-5.33, P = .008) as independent risk factor for death. Surprisingly, recipient genotypes did not influence outcome and there were no differences regarding aGVHD. Transplantation-related mortality (TRM), relapse and pneumonia were significantly less frequent in patients with CC donors. These findings add to the growing list of non-HLA polymorphisms with impact on outcome after allogeneic HSCT.
Hauser
Hanns
H
1st Department of Internal Medicine, Elisabethinen Hospital, Linz, Austria. hanns.hauser@elisabethinen.or.at
Zach
Otto
O
Krieger
Otto
O
Kasparu
Hedwig
H
Koenig
Josef
J
Girschikofsky
Michael
M
Oberbauer
Rainer
R
Lutz
Dieter
D
D000208:Acute Disease; D000328:Adult; D000483:Alleles; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006086:Graft vs Host Disease / Q000201:enzymology / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007422:Intestines / Q000201:enzymology / Q000276:immunology / Q000382:microbiology; D043322:Lactase / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D012307:Risk Factors; D014019:Tissue Donors; D014184:Transplantation, Homologous
D043322:Lactase