Preparation and antimicrobial behaviour of quaternary ammonium thiol derivatives able to be grafted on metal surfaces.
New thiol derivatives containing a quaternary ammonium group bearing variable hydrocarbon chains via an amide connector or not between the sulphur and nitrogen atoms were synthesised with the future aim to be grafted on metal surfaces for obtaining contact-active auto-bactericidal surfaces. Their biostatic and bactericidal activities were evaluated against four microbial strains (Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus niger and Candida albicans). The presence of the thiol and amide functions in these surfactants was discussed in relation with the antimicrobial activity along with the influence of the length of alkyl chains in order to determine which molecular parameters are 'critical' for biological activity, and consequently what molecules must be chosen for grafting on metal surface.
Institut de Chimie de Nice FR 3037 CNRS, Laboratoire de Chimie des Matériaux Organiques et Métalliques, CMOM, UFR Sciences, Université de Nice-Sophia Antipolis, Parc Valrose, 06108 Nice Cedex 2, France. Pascal.Thebault@unice.fr
Pascal
P
Thebault
Elisabeth
E
Taffin de Givenchy
Richard
R
Levy
Yves
Y
Vandenberghe
Frédéric
F
Guittard
Serge
S
Géribaldi
D000327:Adsorption; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents; D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D008670:Metals; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013499:Surface Properties; D013501:Surface-Active Agents
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D008670:Metals; D000644:Quaternary Ammonium Compounds; D013438:Sulfhydryl Compounds; D013501:Surface-Active Agents