Prevalence of chromosomal mosaicism in pregnancies from couples with infertility.
OBJECTIVE
To determine if mosaicism that occurs in infertility and assisted reproductive technologies continues in the late first trimester and if this is unique to infertility or occurs in all pregnancies.


METHODS
Retrospective case-controlled study.


METHODS
University hospital.


METHODS
5337 consecutive chorionic villus samplings (CVS).


METHODS
None.


METHODS
Mosaic karyotypes at CVS.


RESULTS
We confirmed 69 mosaic karyotypes, a rate of 1.29%. Comparing spontaneous pregnancies with pregnancies from infertility treatment, no difference was found in the prevalence of mosaicism: 1.22% versus 1.32%, respectively. Subgroup analysis of infertile couples, comparing in vitro (assisted reproduction) with in vivo fertilization (other treatments) revealed a mosaicism rate of 1.84% and 0.41%, respectively. Confined placental mosaic (CPM) rates for infertility treated pregnancies and spontaneously conceived pregnancies were 0.88% and 0.92%, respectively. Subgroup analysis of infertile patients revealed a CPM rate of 1.15% for in vitro fertilization treatment and 0.41% for in vivo fertilization treatment. These results were not statistically significant.


CONCLUSIONS
There was no difference in the prevalence of mosaicism at the end of the first trimester in pregnancies conceived spontaneously compared with those with infertility. There was no difference in the prevalence of mosaicism when in vitro and in vivo treatment were compared.
Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Andy
A
Huang
Jasvant
J
Adusumalli
Satin
S
Patel
Jennifer
J
Liem
John
J
Williams
Margareta D
MD
Pisarska
D000649:Amniocentesis; D016022:Case-Control Studies; D015193:Chorionic Villi Sampling / Q000379:methods; D005260:Female; D006801:Humans; D007621:Karyotyping; D009030:Mosaicism / Q000706:statistics & numerical data*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D012729:Sex Chromosome Aberrations / Q000706:statistics & numerical data; D016216:Ultrasonography, Prenatal