Double vs single internal thoracic artery harvesting in diabetic patients: role in perioperative infection rate.
BACKGROUND
The aim of this prospective study is to evaluate the role in the onset of surgical site infections of bilateral internal thoracic arteries harvesting in patients with decompensated preoperative glycemia.


METHODS
81 consecutive patients with uncontrolled diabetes mellitus underwent elective CABG harvesting single or double internal thoracic arteries. Single left ITA was harvested in 41 patients (Group 1, 50.6%), BITAs were harvested in 40 (Group 2, 49.4%). The major clinical end points analyzed in this study were infection rate, type of infection, duration of infection, infection relapse rate and total hospital length of stay.


RESULTS
Five patients developed sternal SSI in the perioperative period, 2 in group 1 and 3 in group 2 without significant difference. All sternal SSIs were superficial with no sternal dehiscence. The development of infection from the time of surgery took 18.5 +/- 2.1 and 7.3 +/- 3.0 days for Groups 1 and 2 respectively. The infections were treated with wound irrigation and debridement, and with VAC therapy as well as with antibiotics. The VAC system was removed after a mean of 12.8 +/- 5.1 days, when sterilization was achieved. The overall survival estimate at 1 year was 98.7%. Only BMI was a significant predictor of SSI using multivariate stepwise logistic regression analysis (Odds Ratio: 1.34; 95%Conficdence Interval: 1.02-1.83; p value: 0.04). In the model, the use of BITA was not an independent predictor of SSI.


CONCLUSIONS
CABG with bilateral pedicled ITAs grafting could be performed safely even in diabetics with poor preoperative glycaemic control.
Agrifoglio
Marco
M
Department of Cardiovascular Surgery, Centro Cardiologico Monzino, University of Milan, Via Parea 4, 20138 Milan, Italy. marco.agrifoglio@unimi.it
Trezzi
Matteo
M
Barili
Fabio
F
Dainese
Luca
L
Cheema
Faisal H
FH
Topkara
Veli K
VK
Ghislandi
Chiara
C
Parolari
Alessandro
A
Polvani
Gianluca
G
Alamanni
Francesco
F
Biglioli
Paolo
P
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D017023:Coronary Angiography; D047549:Coronary Artery Bypass, Off-Pump / Q000379:methods*; D003327:Coronary Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D003920:Diabetes Mellitus / Q000097:blood / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007902:Length of Stay; D008297:Male; D008323:Mammary Arteries / Q000637:transplantation*; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000453:epidemiology*; D020858:Tissue and Organ Harvesting / Q000379:methods*
D001786:Blood Glucose