Primary headache and multiple sclerosis: preliminary results of a prospective study.
The aim of this study was to explore the association between different types of headache (HA) and the clinical features of multiple sclerosis (MS). The relationship between HA and MS-specific therapies was also analysed. A total of 102 MS patients were recruited at the MS Centre of S. Andrea Hospital in Rome. According to International Headache Society criteria, the lifetime prevalence of primary HA was 61.8%. Migraine was observed more often in young relapsing-remitting MS patients, whilst tension-type HA was associated with older age, male gender and a secondary progressive course. Sixty-four patients had a history of ongoing or past interferon beta (IFNb) exposure. Of these, 17 subjects did not have a history of HA, while 24 complained of an increase in frequency of migraine attacks and 7 reported an IFNb-induced HA. Investigating and treating HA in MS patients starting IFNb therapy may improve MS-specific medication compliance.
Villani
Veronica
V
Neurology Unit, S. Andrea Hospital La Sapienza University, Via di Grottarossa 1035, 00189 Rome, Italy. veronicavillani@hotmail.it
Prosperini
Luca
L
Ciuffoli
Alessandro
A
Pizzolato
Raffaella
R
Salvetti
Marco
M
Pozzilli
Carlo
C
Sette
Giuliano
G
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D051270:Headache Disorders, Primary / Q000150:complications*; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000188:drug therapy; D011446:Prospective Studies; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
D016899:Interferon-beta