"Nought may endure but mutability": spliceosome dynamics and the regulation of splicing.
The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction.
Smith
Duncan J
DJ
The Rockefeller University, New York, NY 10065, USA.
Query
Charles C
CC
Konarska
Maria M
MM
D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism; D017398:Alternative Splicing; D000818:Animals; D001483:Base Sequence; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry / Q000235:genetics*; D012326:RNA Splicing / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D017381:Spliceosomes / Q000235:genetics* / Q000378:metabolism
D012333:RNA, Messenger; D012313:RNA; D000251:Adenosine Triphosphatases