Cerebrospinal fluid gamma-globulins in subacute sclerosing leucoencephalitis.
Immunoelectrophoresis, gel filtration-electrophoresis and immuno-gel filtration of cerebral fluid samples obtained from five patients with subacute sclerosing leucoencephalitis and known to contain an abnormal gamma-globulin fraction (gammac) produced strong evidence that the gammac-globulin is made up of several components of small molecular size. This fraction is obviously not homogeneous, since some of the cases show more than one precipitate on immuno-gel filtration with immune serum against y-globulin. The gammac appears to be closely related to the Fab-fragment of human gamma-globulin.
Department of Neurology, Psychiatric Research Centre, University of Göteborg, Clinic II of Lillhagen Mental Hospital, Göteborg.
L
L
Bergmann
S J
SJ
Dencker
B G
BG
Johansson
L
L
Svennerholm
D002850:Chromatography, Gel / Q000379:methods; D002855:Chromatography, Thin Layer; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D006801:Humans; D013344:Subacute Sclerosing Panencephalitis / Q000134:cerebrospinal fluid*; D005719:gamma-Globulins / Q000134:cerebrospinal fluid*
D005719:gamma-Globulins