The influence of myocardial substrate on ventricular fibrillation waveform: a swine model of acute and postmyocardial infarction.
OBJECTIVE
In cardiac arrest resulting from ventricular fibrillation, the ventricular fibrillation waveform may be a clue to its duration and predict the likelihood of shock success. However, ventricular fibrillation occurs in different myocardial substrates such as ischemia, heart failure, and structurally normal hearts. We hypothesized that ventricular fibrillation is altered by myocardial infarction and varies from the acute to postmyocardial infarction periods.


METHODS
An animal intervention study was conducted with comparison to a control group.


METHODS
This study took place in a university animal laboratory.


METHODS
Study subjects included 37 swine.


METHODS
Myocardial infarction was induced by occlusion of the midleft anterior descending artery. Ventricular fibrillation was induced in control swine, acute myocardial infarction swine, and in postmyocardial infarction swine after a 2-wk recovery period.


RESULTS
Ventricular fibrillation was recorded in 11 swine with acute myocardial infarction, ten postmyocardial infarction, and 16 controls. Frequency (mean, median, dominant, and bandwidth) and amplitude-related content (slope, slope-amp [slope divided by amplitude], and amplitude-spectrum area) were analyzed. Frequencies at 5 mins of ventricular fibrillation were altered in both acute myocardial infarction (p < .001 for all frequency characteristics) and postmyocardial infarction swine (p = .015 for mean, .002 for median, .002 for dominant frequency, and <.001 for bandwidth). At 5 mins, median frequency was highest in controls, 10.9 +/- .4 Hz; lowest in acute myocardial infarction, 8.4 +/- .5 Hz; and intermediate in postmyocardial infarction, 9.7 +/- .5 Hz (p < .001 for acute myocardial infarction and p = .002 for postmyocardial infarction compared with control). Slope and amplitude-spectrum area were similar among the three groups with a shallow decline after minute 2, whereas slope-amp remained significantly altered for acute myocardial infarction swine at 5 mins (p = .003).


CONCLUSIONS
Ventricular fibrillation frequencies depend on myocardial substrate and evolve from the acute through healing phases of myocardial infarction. Amplitude related measures, however, are similar among these groups. It is unknown how defibrillation may be affected by relying on the ventricular fibrillation waveform without considering myocardial substrate.
Indik
Julia H
JH
Sarver Heart Center at The University of Arizona College of Medicine, Tucson, AZ, USA. jindik@email.arizona.edu
Donnerstein
Richard L
RL
Hilwig
Ronald W
RW
Zuercher
Mathias
M
Feigelman
Justin
J
Kern
Karl B
KB
Berg
Marc D
MD
Berg
Robert A
RA
D000818:Animals; D016887:Cardiopulmonary Resuscitation; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D047548:Defibrillators; D005260:Female; D009203:Myocardial Infarction / Q000145:classification / Q000209:etiology* / Q000503:physiopathology*; D013552:Swine; D014693:Ventricular Fibrillation / Q000150:complications* / Q000503:physiopathology / Q000628:therapy