The use of photodynamic therapy for diseases of the esophagus.
This is a review of the uses, history, and current status of photodynamic therapy for diseases of the esophagus, specifically Barrett's dysplasia and early esophageal carcinoma. This paper describes the clinical experience of photodynamic therapy and compares the use of various photosensitizer drugs. Finally, important biophotonics developments are discussed, including their anticipated impact for improved endoscopic detection of dysplasia and carcinoma. In addition, methods for real-time photodynamic therapy and light dosimetry are provided in order to optimize ablation treatment outcomes while minimizing the risk of complications.
Gross
Seth A
SA
Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, MN, USA.
Wolfsen
Herbert C
HC
D004307:Dose-Response Relationship, Radiation; D004935:Esophageal Diseases / Q000188:drug therapy* / Q000601:surgery; D006414:Hematoporphyrin Photoradiation / Q000379:methods; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*
D017319:Photosensitizing Agents