Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer's type in an elderly Arab population in Wadi Ara, Israel.
The angiotensin-converting enzyme (ACE), a protease involved in blood pressure regulation, has been implicated as an important candidate gene for Alzheimer's disease (AD). This study investigated whether the ACE gene insertion-deletion (ID) polymorphism is associated with risk of developing dementia of Alzheimer's type (DAT) in an Arab-Israeli community, a unique genetic isolate where there is a high prevalence of DAT. In contrast to several other studies, we found no evidence of an association between this polymorphism and either DAT or age-related cognitive decline (ARCD).
Genetic Program, Boston University School of Medicine, Boston, MA, USA. bowirrat@bu.edu
Abdalla
A
Bowirrat
Jing
J
Cui
Kristin
K
Waraska
Robert P
RP
Friedland
Marlene
M
Oscar-Berman
Lindsay A
LA
Farrer
Amos
A
Korczyn
Clinton T
CT
Baldwin