Diffuse cerebral infarct associated with factor V Leiden and prothrombin 20210A mutations in a patient with tetralogy of Fallot.
A 2-year-old girl with tetralogy of Fallot presented with diffuse cranial infarct after cardiac angiography. Heterozygosity for factor V Leiden and prothrombin 20210A mutations were detected. The authors suggest that if thrombosis develops in patients with congenital heart disease, genetic risk factors should be evaluated.
Sipahi
Tansu
T
Department of Pediatric Hematology, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey. tansusipahi@hotmail.com
Karademir
Selmin
S
Kuybulu
Ayça
A
Akar
Nejat
N
D002675:Child, Preschool; D005165:Factor V / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006495:Heparin, Low-Molecular-Weight; D006801:Humans; D009154:Mutation; D011516:Prothrombin / Q000235:genetics; D020521:Stroke / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D013771:Tetralogy of Fallot / Q000150:complications*; D014859:Warfarin
D006495:Heparin, Low-Molecular-Weight; C095381:factor V Leiden; D014859:Warfarin; D005165:Factor V; D011516:Prothrombin