Alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata WIGHT).
A polyhydroxylated cyclic 13-membered sulfoxide (1) was isolated from an aqueous extract of Kothala-himbutu ( Salacia reticulata WIGHT). The structure of compound 1 was elucidated by 1D and 2D NMR and APCI-MS methods. The alpha-glucosidase inhibitory activity of compound 1 (IC 50: maltase, 0.227 microM; sucrase, 0.186 microM; isomaltase, 0.099 microM) was much greater than the inhibitory activity of salacinol and kotalanol, which were previously isolated from Kothala-himbutu.
Research Institute, Fuji-Sangyo Co., Ltd., Marugame, Kagawa 763-0071, Japan.
Sei
S
Ozaki
Hiromi
H
Oe
Shinichi
S
Kitamura
D000818:Animals; D065089:Glycoside Hydrolase Inhibitors; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007421:Intestine, Small / Q000201:enzymology; D015394:Molecular Structure; D009005:Monosaccharides / Q000737:chemistry / Q000302:isolation & purification; D010179:Pancreas / Q000201:enzymology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D049918:Salacia / Q000737:chemistry*; D013188:Sri Lanka; D013393:Sucrase / Q000187:drug effects; D013402:Sugar Alcohols / Q000737:chemistry / Q000302:isolation & purification; D013431:Sulfates / Q000737:chemistry / Q000302:isolation & purification; D013457:Sulfur Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013552:Swine; D000516:alpha-Amylases / Q000037:antagonists & inhibitors; D000520:alpha-Glucosidases / Q000187:drug effects
D065089:Glycoside Hydrolase Inhibitors; D006573:Heterocyclic Compounds, 1-Ring; C114502:Kotalanol; D009005:Monosaccharides; D013402:Sugar Alcohols; D013431:Sulfates; D013457:Sulfur Compounds; C427963:salacinol; D000516:alpha-Amylases; D000520:alpha-Glucosidases; D013393:Sucrase