Placental-site trophoblastic tumor with PET scan-detected surgically treated lung metastasis.
Metastatic placental-site trophoblastic tumor (PSTT) continues to be a diagnostic and management dilemma due to its relative resistance to chemotherapy and the difficulties in diagnosing such a rare tumor. We describe a 35-year-old woman with PSTT presenting with irregular bleeding and a mass in the lung. Dilation and curettage provided the diagnosis of PSTT by frozen section of the specimen. Subsequently, a total abdominal hysterectomy was performed and the patient received three cycles of EMA-CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine) Positron emission tomography (PET) scan confirmed a persistent lung nodule that was treated with wedge resection. She is currently in clinical remission. Surgery may have a role in salvaging a patient with persistent PET-positive disease after chemotherapy.
Department of Obstetrics and Gynecology, Brody School of Medicine of East Carolina University, 600 Moye Boulevard, 2S12 Brody Medical Science Building, Greenville, NC 27834, USA. lucybethnieves@netzero.com
Lucybeth
L
Nieves
James
J
Hoffman
Gretchen
G
Allen
John
J
Currie
Joel I
JI
Sorosky
D000328:Adult; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery; D049268:Positron-Emission Tomography; D011247:Pregnancy; D018245:Trophoblastic Tumor, Placental Site / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery; D014594:Uterine Neoplasms / Q000473:pathology* / Q000601:surgery