Quantification of myocardial perfusion by contrast-enhanced 64-MDCT: characterization of ischemic myocardium.
OBJECTIVE
Assessment of hemodynamic changes in ischemic cardiac segments at rest using CT has yet to be performed. We hypothesized that variations in subendocardial perfusion during the cardiac cycle might be related to the appearances of ischemia. The purpose of this study was to investigate myocardial perfusion in ischemic segments using contrast-enhanced 64-MDCT.


METHODS
We performed cardiac MDCT at rest and stress/rest (201)Tl myocardial perfusion scintigraphy (MPS) in 34 patients with suspected coronary artery disease. We reconstructed 2D long- and short-axis cardiac images in diastolic and systolic phases using raw data from coronary CT angiography. The attenuation value (in Hounsfield units) in the myocardium was used as an estimate of myocardial perfusion. We measured the subendocardial intensity of 17 segments according to the American Heart Association classification. Systolic perfusion or diastolic perfusion was calculated by dividing the subendocardial intensity at systole or diastole, respectively, for each segment by the mean value across all segments for each patient. We used stress/rest MPS to evaluate the variation in myocardial perfusion at systole and diastole for the segments diagnosed as ischemic or nonischemic.


RESULTS
Systolic perfusion for ischemic segments was significantly lower than that for nonischemic segments in 15 of 17 segments. The difference between systolic perfusion and diastolic perfusion in ischemic segments was significantly lower than that in nonischemic segments (14 of 17 segments). There was no significant difference in diastolic perfusion between ischemic and nonischemic segments (15 of 17 segments).


CONCLUSIONS
Our results suggest that a pattern of subendocardial hypoperfusion at systole and normal perfusion at diastole characterizes ischemic myocardium.
Nagao
Michinobu
M
Department of Radiology, Prefectural Ehime Imabari Hospital, Ishii-cho 4-5-5, Imabari-city, Ehime 794-0006, Japan.
Matsuoka
Hiroshi
H
Kawakami
Hideo
H
Higashino
Hiroshi
H
Mochizuki
Teruhito
T
Murase
Kenya
K
Uemura
Masahiko
M
D000328:Adult; D000368:Aged; D003287:Contrast Media; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*; D014283:Triiodobenzoic Acids; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C054871:ioversol