[The relation of the activity of postheparin lipoprotein lipase with the CBC parameters in patients with acute coronary syndrome].
The aim of presented investigation was to study of the relation of the activity of postheparin lipoprotein lipase (LPL) with the blood test parameters in patients with acute coronary syndrome(ACS) during first 6-12 hours after appearance of acute anginous pain. 47 patients with the disease of coronary arteries (DCA) have been investigated. Acute form of ACS was revealed in 27 patients (mean age--62.9+/-11.7 years), chronic form--in 20 patients (mean age 67.9+/-14.0 years). The study was carried out in the first 6-12 hours after appearance of acute anginous pain. Control group consisted of 23 healthy subjects (mean age--37.5+/-8.9 years). Postheparin activity of LPL has been determined in whole cohort by potentiometric method. Blood test was carried out by standard method. The acute coronary syndrome was confirmed by electrocardiographic findings. In ACS group the activity of LPL significantly correlated inversely with the value of leukocytes (r=-0.4022, p=0.038), stab (r=-0.4808, p=0.011) and segmental leukocytes (r=-0.5853, p=0.001), erythrocyte sedimentation rate (r=-0.4188, p=0.030). Corning to the comparative analysis of chronic and acute forms of DCA, the activity of LPL was significantly lower in patients with chronic form compared to the acute form (p=0.043). Therefore, based on the obtained data it should be concluded that in 6-12 hours after development of acute coronary syndrome during worsening the inflammatory reaction (which reflected on the parameters of blood test) together with endothelial dysfunction it is expressed the decrease of the activity of endothelial enzyme LPL.
Svanidze
N O
NO
Kavtaradze
G V
GV
Tananashvili
D E
DE
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000201:enzymology* / Q000503:physiopathology; D000368:Aged; D001772:Blood Cell Count; D004730:Endothelium, Vascular / Q000201:enzymology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D008071:Lipoprotein Lipase