Turner mosaicism (45,X/46,XX) diagnosed in a young woman subsequent to low oocyte maturity and failed ICSI.
OBJECTIVE
To report a case of Turner mosaicism with low oocyte maturity during ICSI.


METHODS
Retrospective case report.


METHODS
Academic tertiary medical center.


METHODS
A 28-year-old patient with 7-year history of primary unexplained infertility.


METHODS
Four cycles of ICSI.


METHODS
Oocyte quality; fertilization, cleavage, and implantation rates; and live births during ICSI cycles; as well as patient karyotype were obtained.


RESULTS
Over four cycles of ICSI, 111 oocytes were harvested, a high follicular response, but 68% were immature (germinal vesicles or metaphase I). Additionally, seven embryos were transfered, but none implanted. Owing to this unusual response in a young healthy woman, maternal karyotype was performed, which demonstrated 17% Turner mosaicism.


CONCLUSIONS
This is, to our knowledge, the first reported case of excellent ovarian response but marked oocyte immaturity in a young woman with Turner mosaicism. The implications of sex chromosome aneuploidy on fertility and the significance of low oocyte maturity are discussed.
Baystate Reproductive Medicine, Baystate Medical Center, Springfield, Massachusetts, USA. andrew.moore@bhs.org
Andrew K
AK
Moore
Kelly
K
Lynch
Margaret J
MJ
Arny
Daniel R
DR
Grow
D000328:Adult; D041321:Chromosomes, Human, X; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D007621:Karyotyping; D009030:Mosaicism; D009865:Oocytes / Q000473:pathology*; D010062:Ovulation Induction; D020554:Sperm Injections, Intracytoplasmic; D017211:Treatment Failure; D014424:Turner Syndrome / Q000150:complications / Q000175:diagnosis* / Q000235:genetics