Pattern of potential drug-drug interactions in diabetic out-patients in a tertiary care teaching hospital in Nepal.
A prospective study was conducted at Manipal Teaching Hospital, Pokhara, Nepal to identify and analyze the pattern of the potential DDIs (drug-drug interaction) in diabetes patients. A total of 182 patients who were prescribed 685 drugs (average, 3.76 drugs per prescription) were enrolled. Patients 51 to 60 years of age had a higher risk [43 patients, or (23.6%)] of developing DDIs. It was found that 174 (92.1%) of the potential DDIs were of "moderate" severity. Cardiovascular drugs carried a risk of DDIs (187 drugs, or 49.5%). The most common potential DDI observed was between metformin and enalapril (n = 64).
Dinesh
K U
KU
Department of Hospital and Clinical Pharmacy/Pharmacology, Manipal Teaching Hospital / Manipal College of Medical Sciences, Pokhara, Nepal. dinesh17dec@rediffmail.com
Subish
P
P
Pranaya
M
M
Shankar
P Ravi
PR
Anil
S K
SK
Durga
B
B
D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004347:Drug Interactions; D004656:Enalapril / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use; D015994:Incidence; D008297:Male; D008687:Metformin / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D009390:Nepal; D010045:Outpatients; D011446:Prospective Studies; D012307:Risk Factors
D000959:Antihypertensive Agents; D007004:Hypoglycemic Agents; D004656:Enalapril; D008687:Metformin