Integrins put the brakes on microcluster dynamics at the immunological synapse.
Integrin engagement costimulates T cell receptor signaling, but the underlying mechanisms are poorly understood. In this issue of Immunity, Nguyen et al. (2008) show that engagement of VLA-4 promotes sustained signaling by altering the dynamics of actin filaments and signaling molecules at the immunological synapse.
Burkhardt
Janis K
JK
Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. jburkhar@mail.med.upenn.edu
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D017951:Antigen Presentation; D006801:Humans; D039041:Integrin alpha4beta1 / Q000378:metabolism*; D008213:Lymphocyte Activation; D010750:Phosphoproteins / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D039041:Integrin alpha4beta1; D010750:Phosphoproteins; D011948:Receptors, Antigen, T-Cell; C092947:SLP-76 signal Transducing adaptor proteins