Nasal polyposis: is there an inheritance pattern? A single family study.
BACKGROUND
Nasal Polyposis (NP) is defined as a chronic inflammatory disease of sinonasal mucosa leading to diffuse formation of benign polyps. Although family histories are frequently suggested in medical literature, no specific study focused on this point has been reported. The purpose of this study is to determine whether a hereditary factor could be implied for NP in a family where several members were affected. We included 99 members of this family.


METHODS
All patients were assessed for conditions known to be associated with the development or presence of NP. Concerning NP, patients were screened with a validated questionnaire and selected patients had a medical examination by an Ear, Nose and Throat practitioner.


RESULTS
Thirteen patients had a personal history of NP without asthma, aspirin intolerance, Churg Strauss syndrome, cystic fibrosis, Young's syndrome, bare lymphocyte syndrome, or primary ciliary dyskinesia. Within this family, 19.7% of those older than 17 years were affected by NP, as compared with the national French prevalence of 2.1%.


CONCLUSIONS
Regarding the pedigree, we discuss different modes of inheritance. The presence of consanguineous unions in this family suggests the possibility of a common ancestor and thus a recessive autosomal mode of inheritance.
Delagrand
A
A
Department of Otorhinolaryngology-Head & Neck Surgery, University Hospital Poitiers, Poitiers, France. a.delagranda@chu-poitiers.fr
Gilbert-Dussardier
B
B
Burg
S
S
Allano
G
G
Gohler-Desmonts
C
C
Lebreton
J P
JP
Dufour
X
X
Klossek
J M
JM
D000293:Adolescent; D000328:Adult; D002648:Child; D003241:Consanguinity; D005260:Female; D005602:France; D008040:Genetic Linkage / Q000235:genetics; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D010254:Paranasal Sinus Diseases / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D010375:Pedigree