Experimental nodel of C6 brain tumors in athymic rats.
Malignant brain tumor experimental models tend to employ cells that are immunologically compatible with the receptor animal. In this study, we have proposed an experimental model of encephalic tumor development by injecting C6 cells into athymic Rowett rats, aiming at reaching a model which more closely resembles to the human glioma tumor. In our model, we observed micro-infiltration of tumor cell clusters in the vicinity of the main tumor mass, and of more distal isolated tumor cells immersed in normal encephalic parenchyma. This degree of infiltration is superior to that usually observed in other C6 models.
Miura
Flávio K
FK
Department of Neurology, Medical School, University of São Paulo, São Paulo, Brazil. fkmiura@hotmail.com
Alves
Maria José Ferreira
MJ
Rocha
Mussya Cisotto
MC
Silva
Roseli S
RS
Oba-Shinjo
Sueli M
SM
Uno
M
M
Colin
C
C
Sogayar
M C
MC
Marie
Sueli K N
SK
D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D005910:Glioma / Q000473:pathology*; D009361:Neoplasm Invasiveness; D051381:Rats; D011923:Rats, Nude