International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor.
Historically, calcitonin gene-related peptide (CGRP) receptors have been divided into two classes, CGRP(1) and CGRP(2). After the cloning of calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs), it became clear that the CGRP(1) receptor was a complex between CLR and RAMP1. It is now apparent that the CGRP(2) receptor phenotype is the result of CGRP acting at receptors for amylin and adrenomedullin. Accordingly, the term "CGRP(2)" receptor should no longer be used, and the "CGRP(1)" receptor should be known as the "CGRP" receptor.
School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK.
Debbie L
DL
Hay
David R
DR
Poyner
Remi
R
Quirion
D053607:Adrenomedullin / Q000378:metabolism; D000682:Amyloid / Q000378:metabolism; D058228:Islet Amyloid Polypeptide; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000378:metabolism; D009626:Terminology as Topic
D000682:Amyloid; D058228:Islet Amyloid Polypeptide; D018015:Receptors, Calcitonin Gene-Related Peptide; D053607:Adrenomedullin