Thyroid autoantibodies in women with and without thyroid disorders in an iodine-replete area.
To compare the prevalence of positive autoantibodies in patients with thyroid disorders and healthy subjects in an iodine-replete area of the Islamic Republic of Iran, we studied 930 women in a clinic-based study: 698 patients (286 hypothyroid, 140 hyperthyroid, 272 with simple goitre) and 232 healthy women. Serum thyroxine (T4), triiodothyronine (T3), thyroid stimulating hormone, and anti-thyroid antibodies were measured. Positive autoantibodies were detected in 75.5% of patients with hypothyroidism, 73.6% of those with hyperthyroidism, 48.9% of those with simple goitre and 35.8% of the control group (P < 0.001). Autoimmunity may have a role in the genesis of common thyroid disorders.
Isfahan Endocrine and Metabolism Research Centre, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran. aminorroaya@med.mui.ac.ir
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Aminorroaya
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Momenzadeh
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Hovsepian
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Haghighi
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Amini
D000328:Adult; D000704:Analysis of Variance; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003677:Deficiency Diseases / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D005527:Food, Fortified; D006043:Goiter, Endemic / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D007037:Hypothyroidism / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D007453:Iodide Peroxidase / Q000276:immunology*; D007455:Iodine / Q000172:deficiency; D007492:Iran / Q000453:epidemiology; D033862:Iron-Binding Proteins / Q000276:immunology*; D009313:National Health Programs; D011159:Population Surveillance; D016036:Seroepidemiologic Studies; D017673:Sodium Chloride, Dietary; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014504:Urban Health / Q000706:statistics & numerical data
D001323:Autoantibodies; D001324:Autoantigens; D033862:Iron-Binding Proteins; D017673:Sodium Chloride, Dietary; C006606:anti-thyroglobulin; D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; C056658:TPO protein, human; D007453:Iodide Peroxidase; D013974:Thyroxine