Evaluation of Etest method for determining isavuconazole MICs against Cryptococcus gattii and Cryptococcus neoformans.
We compared Etest with broth microdilution testing for isavuconazole activity against 92 Cryptococcus isolates. A 97.8% agreement was found between these methods, without major discrepancies (>2-well dilution difference). Our findings support the use of the Etest methodology as a reliable method for the determination of MICs against Cryptococcus spp.
Department of Internal Medicine, Division of Infectious Diseases, UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. thompsong2@uthscsa.edu
George R
GR
Thompson
Annette W
AW
Fothergill
Nathan P
NP
Wiederhold
Ana C
AC
Vallor
Brian L
BL
Wickes
Thomas F
TF
Patterson
D000935:Antifungal Agents / Q000494:pharmacology; D003454:Cryptococcus / Q000187:drug effects*; D003455:Cryptococcus neoformans / Q000187:drug effects*; D008826:Microbial Sensitivity Tests / Q000379:methods*; D009570:Nitriles / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D015203:Reproducibility of Results; D013045:Species Specificity; D014230:Triazoles / Q000494:pharmacology*
D000935:Antifungal Agents; D009570:Nitriles; D011725:Pyridines; D014230:Triazoles; C508735:isavuconazole