[Mechanisms underlying thyroid hormone response gene regulation during amphibian development].
Amphibian metamorphosis is an excellent model to study the diverse effects of thyroid hormones (TH). TH modulate target gene expression via thyroid hormone receptors (TR). Generally, unliganded TR repress transcription, whereas liganded TR activate transcription. During metamorphosis, these dual effects of TR are evident. Moreover, we show that gene specific response to TH can underline the multiple effects of TH. Finally, studies of unliganded-thyroid hormone receptor function reveal a physiological role in eye development.
UMR5166 CNRS, USM-501 Muséum National d'Histoire Naturelle, Département Régulation Développement et Diversité Moléculaire, CP32, 7 rue Cuvier, 75231 Paris Cedex 05, France.
Emmanuelle
E
Havis
Patrice
P
Bilesimo
Barbara A
BA
Demeneix
Laurent M
LM
Sachs
D000663:Amphibians / Q000196:embryology / Q000235:genetics* / Q000254:growth & development*; D000818:Animals; D030801:Animals, Genetically Modified / Q000196:embryology / Q000235:genetics; D002843:Chromatin / Q000187:drug effects; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects*; D008675:Metamorphosis, Biological / Q000235:genetics; D023421:Models, Animal; D016296:Mutagenesis; D011988:Receptors, Thyroid Hormone / Q000235:genetics* / Q000502:physiology; D020218:Response Elements / Q000187:drug effects* / Q000235:genetics; D013963:Thyroid Hormones / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology
D002843:Chromatin; D011988:Receptors, Thyroid Hormone; D013963:Thyroid Hormones; D014284:Triiodothyronine