Lack of association between Fc receptor-like 3 gene polymorphisms and systemic lupus erythematosus in Chinese population.
BACKGROUND
It is reported that Fc receptor-like gene 3 (FCRL3) was linked to a variety of autoimmune diseases in Japanese. However, studies in Caucasians and Koreans failed to confirm this result.


OBJECTIVE
The aim of the study was to test FCRL3 gene polymorphisms for association with systemic lupus erythematosus (SLE) in Chinese han population.


METHODS
We analyzed four single nucleotide polymorphisms (SNPs) (rs7528684, rs11264799, rs945635 and rs3761959) in a case-control cohort composed of 248 SLE patients and 278 healthy controls using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.


RESULTS
Analysis of genotype frequencies revealed no significant difference between SLE patients and control subjects for the FCRL3 gene polymorphisms, we also inferred common haplotypes and found no significant difference of haplotype frequency between SLE patients and controls. The FCLR3 genotypes were also not associated with antinuclear antibody (ANA) in the SLE patients.


CONCLUSIONS
These results suggested that genetic variations in FCRL3 were not associated with SLE in Chinese population.
Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Yi
Y
You
Zhe
Z
Wang
Guohong
G
Deng
Fei
F
Hao
D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*
C457775:FCRL3 protein, human; D011971:Receptors, Immunologic