L-myc gene polymorphism and risk of thyroid cancer.
L-myc gene polymorphism is a representative genetic trait responsible for an individual's susceptibility to several cancers. However, there have been no reports concerning the association between thyroid cancer and L-myc gene polymorphism.


OBJECTIVE
To analyze the distribution of L-myc gene polymorphism in Turkish patients with thyroid disorders and thyroid cancers.


METHODS
We used a molecular genotyping method, polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). We studied 138 patients of whom 47 had multinodular goiter, 13 had follicular cancer and 69 had papillar cancer, in comparison with control group of 109 healthy individuals.


RESULTS
No significant difference in the distribution of genotypes was observed between thyroid patients and controls. Carrying SS or LS genotype revealed a 1.96-fold (95% CI 0.573-6.706) risk for the occurrence of follicular cancer when compared with controls, and 3.11-fold (95% CI 0.952-10.216), when compared with multinodular goiter patients (p=0.04).


CONCLUSIONS
We suggest that L-myc genotype profiling together with other susceptibility factors, may be useful in the screening for thyroid nodular malignancy.
Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul University, Istanbul Research and Education Hospital, Surgery Clinic, Istanbul, Turkey.
I
I
Yaylim-Eraltan
N
N
Bozkurt
A
A
Ergen
U
U
Zeybek
O
O
Ozturk
S
S
Arikan
Y
Y
Erbil
I
I
Uslu
H
H
Camlica
T
T
Isbir
D004247:DNA / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D012306:Risk; D013959:Thyroid Diseases / Q000235:genetics / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000378:metabolism; D014421:Turkey
D016271:Proto-Oncogene Proteins c-myc; D004247:DNA