Increased expression levels of tensin3 mRNA in thyroid functional adenomas as compared to non-functioning adenomas.
Tensin3 is a member of tensin family which is localized in focal adhesion. In our previous study, a high level of tensin3 mRNA expression was observed in the thyroid but not in other tissues, thus, tensin3 gene was regarded as a novel thyroid-specific gene. The high expression level of tensin3 mRNA in normal thyroid tissue suggests some fundamental roles in thyroid functions. In fact, the expression level of tensin3 mRNA was low in most thyroid carcinomas and non-functioning thyroid follicular adenomas which do not produce thyroid hormone. In the present study, we measured the expression levels of tensin3 mRNA in twelve functional adenomas and compared the results with those in normal thyroid tissues, adenomatous goiters and non-functioning thyroid follicular adenomas. Tensin3 mRNA was expressed abundantly in all twelve functional adenomas at almost the same level as in normal thyroid tissues and adenomatous goiters, while its expression was significantly lower in non-functioning follicular adenomas. Considering these facts, an abundant expression of tensin3 mRNA is observed in tissues that produce thyroid hormone, which suggests some fundamental roles in basic thyroid functions.
Central Laboratory for Clinical Investigation, Osaka University Hospital, Yamadaoka, Suita, Osaka, Japan.
I
I
Maeda
H
H
Yamada
T
T
Takano
E
E
Nishihara
Y
Y
Ito
F
F
Matsuzuka
A
A
Miya
K
K
Kobayashi
H
H
Yoshida
A
A
Miyauchi
Y
Y
Hidaka
D000236:Adenoma / Q000235:genetics*; D003001:Cloning, Molecular; D017931:DNA Primers; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D012334:RNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000070876:Tensins; D013963:Thyroid Hormones / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000235:genetics*
D017931:DNA Primers; D008840:Microfilament Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; C000603370:TNS3 protein, human; D000070876:Tensins; D013963:Thyroid Hormones