Evaluating the validities of different DSM-IV-based conceptual constructs of tobacco dependence.
OBJECTIVE
To compare the concurrent and predictive validities of two subsets of DSM-IV criteria for nicotine dependence (tolerance and withdrawal; withdrawal; difficulty controlling use; and use despite harm) to the concurrent and predictive validity of the full DSM-IV criteria.


METHODS
Analysis of baseline and outcome data from three randomized clinical trials of cigarette smoking treatment.


METHODS
San Francisco, California.


METHODS
Two samples of cigarette smokers (n = 810 and 322), differing with regard to baseline characteristics and treatment received, derived from three randomized clinical trials.


METHODS
DSM-IV nicotine dependence criteria were measured at baseline with a computerized version of the Diagnostic Interview Schedule for DSM-IV (DIS-IV). Additional baseline measures included the Fagerström Test of Nicotine Dependence (FTND), number of cigarettes smoked per day, breath carbon monoxide (CO) level, the Minnesota Nicotine Withdrawal Scale (MNWS), the Michigan Nicotine Reinforcement Questionnaire (M-NRQ) and the Profile of Mood States (POMS). Seven-day point-prevalence abstinence was assessed at week 12.


RESULTS
Full DSM-IV criteria displayed greater concurrent validity than either of the two subsets of criteria. However, DSM-IV symptoms accounted for only a nominal amount of the variance in baseline smoking-related characteristics and were unrelated to smoking abstinence at week 12. Cigarettes smoked per day was the only significant predictor of abstinence at week 12.


CONCLUSIONS
Although the findings do not provide a compelling alternative to the full set of DSM-IV nicotine dependence criteria, its poor psychometric properties and low predictive power limit its clinical and research utility.
University of California, San Francisco, CA, USA. phendricks@lppi.ucsf.edu
Peter S
PS
Hendricks
Judith J
JJ
Prochaska
Gary L
GL
Humfleet
Sharon M
SM
Hall
D000328:Adult; D016739:Behavior, Addictive / Q000523:psychology*; D002140:California; D002248:Carbon Monoxide / Q000032:analysis; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis* / Q000523:psychology; D011795:Surveys and Questionnaires; D014029:Tobacco Use Disorder / Q000175:diagnosis* / Q000523:psychology
D002248:Carbon Monoxide