The synthesis of biodegradable graft copolymer cellulose-graft-poly(L-lactide) and the study of its controlled drug release.
According to the concept of green chemistry and sustainable development, a new biodegradable copolymer comprised of hydrophobic poly(l-lactide) (PLLA) segments and hydrophilic cellulose segment (cellulose-g-PLLA) was designed and synthesized. The structure of the copolymer was characterized by (1)H NMR, FT-IR, (13)C NMR, DSC and WAXD. The cytotoxicity study shows that cellulose-g-PLLA exhibits good biocompatibility. The copolymer can self-assemble into micelles in water with the hydrophobic PLLA segments at the cores of micelles and the hydrophilic cellulose segments as the outer shells. Transmission electron microscopy (TEM) shows that the micelles exhibit nanospheric morphology within a size range of 30-80nm. The drug loaded micelles formed by the copolymer in aqueous media show sustained drug release which indicates their potential applicability in drug carrier.
Dong
Haiqing
H
Department of Polymer Science, Key Laboratory of Biomedical Polymers, Wuhan University, Ministry of Education, Wuhan 430072, People's Republic of China.
Xu
Qi
Q
Li
Yongyong
Y
Mo
Shaobo
S
Cai
Shaojun
S
Liu
Lijian
L
D016475:3T3 Cells; D000818:Animals; D002470:Cell Survival / Q000187:drug effects*; D002482:Cellulose / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems; D052578:Ionic Liquids; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008823:Micelles; D053758:Nanoparticles; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013500:Surface Tension
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D052578:Ionic Liquids; D008823:Micelles; D011091:Polyesters; D011108:Polymers; C033616:poly(lactide); D002482:Cellulose