title: On-line monitoring of hybridoma cell growth using a laser turbidity sensor.
abstract: A high-sensitivity turbidity probe was used for on-line monitoring of the cell concentration in batch hybridoma cultivation. Good correlation between off-line cell counts and the linearized sensor signal was found. The quality of the signal was sufficiently high to provide for on-line estimation of the specific growth rate using an efficient filtering procedure. These positive results suggest that such laser turbidity sensors will facilitate development of systems for on-line monitoring and control of animal cell cultivations.
authors.affiliation: ICBiotech, Faculty of Engineering, Osaka University, Suita shi, Osaka 565, Japan.
authors.forename: K B
authors.initials: KB
authors.lastname: Konstantinov
authors.forename: R
authors.initials: R
authors.lastname: Pambayun
authors.forename: R
authors.initials: R
authors.lastname: Matanguihan
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: C M
authors.initials: CM
authors.lastname: Perusicn
authors.forename: W S
authors.initials: WS
authors.lastname: Hu