BCG osteomyelitis caused by the BCG Tokyo strain and confirmed by molecular method.
Bacille Calmette-Guérin (BCG) osteitis is a rare complication of BCG vaccination. We describe two cases of BCG osteomyelitis developed in Korean infants who were given multipuncture BCG vaccination. The cultures of bone curettage specimens grew mycobacteria. The isolates were identified as BCG Tokyo strains by the deletion of the region of difference 1 (RD1) and characterization of RD8 and RD14 using the multiplex polymerase chain reaction.
Kim
So Hee
SH
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
Kim
So Yeon
SY
Eun
Byung Wook
BW
Yoo
Won Joon
WJ
Park
Kyoung Un
KU
Choi
Eun Hwa
EH
Kim
Eui-Chong
EC
Lee
Hoan Jong
HJ
D004269:DNA, Bacterial / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D007723:Korea; D008297:Male; D009164:Mycobacterium Infections / Q000175:diagnosis* / Q000382:microbiology; D009163:Mycobacterium bovis / Q000235:genetics / Q000302:isolation & purification*; D010019:Osteomyelitis / Q000382:microbiology*; D016133:Polymerase Chain Reaction / Q000379:methods; D032581:Tuberculosis Vaccines / Q000009:adverse effects*
D004269:DNA, Bacterial; D032581:Tuberculosis Vaccines