title: Making the jump: new insights into the mechanism of trans-translation.
abstract: The transfer-messenger ribonucleoprotein (tmRNP), which is composed of RNA and a small protein, small protein B (SmpB), recycles ribosomes that are stalled on broken mRNAs lacking stop codons and tags the partially translated proteins for degradation. Although it is not yet understood how the ribosome gets from the 3' end of the truncated message onto the messenger portion of the tmRNA to add the tag, a recent study in BMC Biology has shed some light on this astonishing feat.
authors.affiliation: Department of Animal Sciences, Auburn University, Auburn, AL 36849, USA. zwieb@uthct.edu
authors.forename: Jacek
authors.initials: J
authors.lastname: Wower
authors.forename: Iwona K
authors.initials: IK
authors.lastname: Wower
authors.forename: Christian
authors.initials: C
authors.lastname: Zwieb
mesh_terms: D014176:Protein Biosynthesis / Q000235:genetics; D011487:Protein Conformation; D012329:RNA, Bacterial / Q000737:chemistry / Q000378:metabolism*; D012270:Ribosomes / Q000737:chemistry / Q000378:metabolism*; D013698:Templates, Genetic
chemical_list: D012329:RNA, Bacterial; C096222:tmRNA