A regio- and stereocontrolled approach to pyranosyl C-nucleoside synthesis.
Six novel diastereomerically pure C-nucleosides have been synthesized from nonchiral starting materials, using the ene/intramolecular Sakurai cyclization reaction demonstrating a simple, general, and stereocontrolled approach to pyranosyl C-nucleosides.
Redpath
Philip
P
Respiratory CEDD, Stevenage SG12NY, UK.
Macdonald
Simon
S
Migaud
Marie E
ME
D008968:Molecular Conformation; D009705:Nucleosides / Q000138:chemical synthesis*; D011714:Pyrans / Q000138:chemical synthesis*; D013237:Stereoisomerism
D009705:Nucleosides; D011714:Pyrans