Effect of acarbose on the increased plasma concentration of uric acid induced by sucrose ingestion.
Sucrose is converted fructose and glucose, which may increase plasma uric acid concentration (pUA) through increased purine degradation and/or decreased uric acid (UA) excretion. To investigate effects of acarbose, an inhibitor of alpha-glucosidase, on the increased pUA from sucrose administration, we measured pUA and urinary UA excretion in 6 healthy subjects before and after administering sucrose, with and without co-administration of acarbose. Sucrose raised pUA by 10% (p < 0.01). However, excretion and fractional clearance of UA were unchanged. Sucrose and acarbose coadministration also increased pUA, but less than did sucrose alone (sucrose: 4.9 to 5.4 mg/dl; sucrose + acarbose, 4.7 to 4.9 mg/dl, p < 0.05) without changes in urinary excretion and fractional clearance of UA. Acarbose appears to attenuate the rise in pUA by sucrose ingestion by inhibiting sucrose absorption.
Moriwaki
Y
Y
Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan. moriwaki@hyo-med.ac.jp
Inokuchi
T
T
Ka
T
T
Yamamoto
A
A
Tsutsumi
Z
Z
Takahashi
S
S
Yamamoto
T
T
D020909:Acarbose / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D004435:Eating; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007328:Insulin / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008297:Male; D011687:Purines / Q000097:blood; D013395:Sucrose / Q000008:administration & dosage / Q000494:pharmacology*; D014527:Uric Acid / Q000097:blood*
D001786:Blood Glucose; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007328:Insulin; D011687:Purines; D014527:Uric Acid; D019344:Lactic Acid; D013395:Sucrose; D020909:Acarbose