title: The effect of MinC on FtsZ polymerization is pH dependent and can be counteracted by ZapA.
abstract: The min system prevents polar cell division in bacteria. Here, the biochemical characterization of the interaction of MinC and FtsZ from a Gram-positive bacterium, Bacillus subtilis, is reported. B. subtilis MinC inhibits FtsZ polymerization in a pH-dependent manner by preventing the formation of lateral associations between filaments. The inhibitory effect of MinC on FtsZ polymerization is counteracted by the presence of ZapA, a protein that promotes FtsZ filament bundling.
authors.affiliation: Department of Molecular Microbiology, Institute of Molecular Cell Biology, VU University Amsterdam, De Boelelaan, The Netherlands. dirk-jan.scheffers@falw.vu.nl
authors.forename: Dirk-Jan
authors.initials: DJ
authors.lastname: Scheffers
mesh_terms: D001412:Bacillus subtilis / Q000166:cytology* / Q000378:metabolism* / Q000648:ultrastructure; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D002455:Cell Division; D003598:Cytoskeletal Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; C071525:FtsZ protein, Bacteria; C080466:MinC protein, Bacteria