Mental retardation and lifetime events of Duchenne muscular dystrophy in Japan.
OBJECTIVE
This study investigated the relationship between mental retardation and lifetime events in patients with Duchenne muscular dystrophy (DMD).


METHODS
The data on mental retardation and ages of lifetime events (first walking, loss of ambulation, introductions of ventilator support and tube nutrition and death) were collected retrospectively, and the relationships between the factors were analyzed.


METHODS
Among 194 DMD patients admitted to our hospital between 1995 and 2007, 74 patients underwent evaluation of their intelligence quotient (IQ).


RESULTS
Twenty-eight patients (38%) demonstrated mental retardation (IQ<70). DMD patients with mental retardation started walking later, required ventilator and tube nutrition support earlier, and died earlier than those without mental retardation.


CONCLUSIONS
Since the prognosis of DMD patients with mental retardation was worse than that of those without mental retardation, more careful treatment is necessary for DMD patients with mental retardation.
Mochizuki
Hitoshi
H
Department of Neurology, Higashi-Saitama National Hospital, Hasuda, Japan. mochizuki-h@umin.ac.jp
Miyatake
Satoko
S
Suzuki
Mikiya
M
Shigeyama
Toshiki
T
Yatabe
Kana
K
Ogata
Katsuhisa
K
Tamura
Takuhisa
T
Kawai
Mitsuru
M
D000293:Adolescent; D000328:Adult; D002648:Child; D002658:Developmental Disabilities / Q000150:complications*; D018450:Disease Progression; D006801:Humans; D008607:Intellectual Disability / Q000150:complications*; D007361:Intelligence Tests; D007564:Japan; D053208:Kaplan-Meier Estimate; D020388:Muscular Dystrophy, Duchenne / Q000150:complications*; D012189:Retrospective Studies