Leading Wnt down a PCP path: Cthrc1 acts as a coreceptor in the Wnt-PCP pathway.
Wnt signaling regulates many aspects of development through canonical and PCP signaling pathways. A paper by Yamamoto et al. in this issue of Developmental Cell identifies collagen triple helix repeat containing 1 as a Wnt-binding cofactor that specifically activates the Wnt-PCP pathway.
Kelley
Matthew W
MW
Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA. kelleymt@nidcd.nih.gov
D000818:Animals; D016764:Cell Polarity / Q000502:physiology*; D004622:Embryo, Mammalian; D051157:Frizzled Receptors / Q000235:genetics / Q000378:metabolism*; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D006199:Hair Cells, Auditory, Inner / Q000166:cytology; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D057050:Receptor Tyrosine Kinase-like Orphan Receptors; D015398:Signal Transduction; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*
D051157:Frizzled Receptors; D006023:Glycoproteins; D051153:Wnt Proteins; D020794:Receptor Protein-Tyrosine Kinases; D057050:Receptor Tyrosine Kinase-like Orphan Receptors; C477010:Ror2 protein, mouse