Effects of cycloheximide on extinction in an appetitively motivated operant conditioning task depend on re-exposure duration.
Little is known about the role of new protein synthesis in extinction of operant responding for natural and chemical reinforcers. In the present study, the authors investigated whether the effects of a protein synthesis inhibitor, cycloheximide (CHX) on extinction of operant responding for sweet reward depended on the duration of re-exposure sessions. In addition, the authors investigated whether the effects of CHX on extinction could generalize to relapse of saccharin seeking induced by discrete cues. CHX injected after short re-exposure sessions (5min) accelerated extinction of non-reinforced responding. In contrast, the drug injected after long re-exposure sessions (30min) partially inhibited extinction. Reinstatement of saccharin seeking induced by the saccharin-paired discrete cues was not altered by the previous treatment with CHX. Concluding, the results of the present study indicate that: (i) the protein synthesis inhibitor, CHX can alter extinction of operant responding for sweet reward in rats; (ii) the effects of CHX on extinction critically depend on the duration of re-exposure/extinction sessions and do not generalize to relapse of saccharin seeking induced by discrete cues.
Mierzejewski
Pawel
P
Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 9 St., PL-02957, Warsaw, Poland. mierzeje@ipin.edu.pl
Olczak
Mieszko
M
Rogowski
Artur
A
Kostowski
Wojciech
W
Samochowiec
Jerzy
J
Filip
Malgorzata
M
Przegalinski
Edmund
E
Bienkowski
Przemyslaw
P
D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects / Q000502:physiology*; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology*; D003463:Cues; D003513:Cycloheximide / Q000494:pharmacology*; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009042:Motivation; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012008:Recurrence; D012054:Reinforcement, Psychology; D012201:Reward; D012439:Saccharin / Q000494:pharmacology; D019966:Substance-Related Disorders / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology; D013997:Time Factors
D009419:Nerve Tissue Proteins; D011500:Protein Synthesis Inhibitors; D003513:Cycloheximide; D012439:Saccharin