title: Chiral transformation of cyanine dye aggregates induced by small peptides.
abstract: Three small peptides (K4, K5, and K6) with different length were designed to induce the transformation of the assembled state and the chirality of cyanine dye supramolecule. The absorption and circular dichroism (CD) results indicated that, the peptides tend to induce cyanine dye to H-aggregation, competed with Na(+) in PBS, which would induce dye to J-aggregation. Meanwhile, all three peptides could influence the chirality of both J-aggregates induced by Na(+) and H-aggregates, among which K6 could induce chiral reversion of J-aggregates. Furthermore, molecular modeling and energy calculation results have shown that the peptides with different chain length have different conformations. This might be the reason for cyanine dye to form the different chiral assembly induced by these oligo-peptide templates.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry for Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: Qianfan
authors.initials: Q
authors.lastname: Yang
authors.forename: Junfeng
authors.initials: J
authors.lastname: Xiang
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Yan
authors.forename: Qiuju
authors.initials: Q
authors.lastname: Zhou
authors.forename: Yalin
authors.initials: Y
authors.lastname: Tang
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Xu
mesh_terms: D000042:Absorption; D000465:Algorithms; D002021:Buffers; D002232:Carbocyanines / Q000737:chemistry*; D002412:Cations; D002942:Circular Dichroism; D004396:Coloring Agents / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D008968:Molecular Conformation; D010455:Peptides / Q000737:chemistry*; D012964:Sodium / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics
chemical_list: D002021:Buffers; D002232:Carbocyanines; D002412:Cations; D004396:Coloring Agents; D010455:Peptides; D006859:Hydrogen; D012964:Sodium