Indomethacin release in relation to the concentration of pharmaceutical excipients.
Indomethacin in vitro release was investigated in relation to the concentration of the pharmaceutical excipients, such as ethanol and propylene glycol. Drug release was studied from gels containing Sepigel 305 as a gelling agent. Not only the concentration of ethanol and propylene glycol influence the rate of indomethacin release, but also Sepigel 305 significantly increased the amount of indomethacin release.
Potúcková
M
M
Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic. vercimakova@fpharm.uniba.sk
Vitková
Z
Z
Tichý
E
E
Simunková
V
V
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D000431:Ethanol; D005079:Excipients; D007213:Indomethacin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D007700:Kinetics; D011409:Propylene Glycols; D012997:Solvents
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005079:Excipients; D011409:Propylene Glycols; D012997:Solvents; D000431:Ethanol; D007213:Indomethacin