title: Replication of association between ELAVL4 and Parkinson disease: the GenePD study.
abstract: Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. In the current study we genotyped three single nucleotide polymorphisms in ELAVL4 in a Caucasian study sample consisting of 712 PD patients and 312 unrelated controls from the GenePD study. The minor allele of rs967582 was associated with increased risk of PD (odds ratio = 1.46, nominal P value = 0.011) in the GenePD population. The minor allele of rs967582 was also the risk allele for PD affection or earlier onset age in the previously studied populations. This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene.
authors.affiliation: Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Crosstown Center, 3rd floor, Boston, MA 02118, USA. adestef@bu.edu
authors.forename: Anita L
authors.initials: AL
authors.lastname: DeStefano
authors.forename: Jeanne
authors.initials: J
authors.lastname: Latourelle
authors.forename: Mark F
authors.initials: MF
authors.lastname: Lew
authors.forename: Oksana
authors.initials: O
authors.lastname: Suchowersky
authors.forename: Christine
authors.initials: C
authors.lastname: Klein
authors.forename: Lawrence I
authors.initials: LI
authors.lastname: Golbe
authors.forename: Margery H
authors.initials: MH
authors.lastname: Mark
authors.forename: John H
authors.initials: JH
authors.lastname: Growdon
authors.forename: G Fredrick
authors.initials: GF
authors.lastname: Wooten
authors.forename: Ray
authors.initials: R
authors.lastname: Watts
authors.forename: Mark
authors.initials: M
authors.lastname: Guttman
authors.forename: Brad A
authors.initials: BA
authors.lastname: Racette
authors.forename: Joel S
authors.initials: JS
authors.lastname: Perlmutter
authors.forename: Lynn
authors.initials: L
authors.lastname: Marlor
authors.forename: Holly A
authors.initials: HA
authors.lastname: Shill
authors.forename: Carlos
authors.initials: C
authors.lastname: Singer
authors.forename: Stefano
authors.initials: S
authors.lastname: Goldwurm
authors.forename: Gianni
authors.initials: G
authors.lastname: Pezzoli
authors.forename: Marie H
authors.initials: MH
authors.lastname: Saint-Hilaire
authors.forename: Audrey E
authors.initials: AE
authors.lastname: Hendricks
authors.forename: Adam
authors.initials: A
authors.lastname: Gower
authors.forename: Sally
authors.initials: S
authors.lastname: Williamson
authors.forename: Michael W
authors.initials: MW
authors.lastname: Nagle
authors.forename: Jemma B
authors.initials: JB
authors.lastname: Wilk
authors.forename: Tiffany
authors.initials: T
authors.lastname: Massood
authors.forename: Karen W
authors.initials: KW
authors.lastname: Huskey
authors.forename: Kenneth B
authors.initials: KB
authors.lastname: Baker
authors.forename: Ilia
authors.initials: I
authors.lastname: Itin
authors.forename: Irene
authors.initials: I
authors.lastname: Litvan
authors.forename: Garth
authors.initials: G
authors.lastname: Nicholson
authors.forename: Alastair
authors.initials: A
authors.lastname: Corbett
authors.forename: Martha
authors.initials: M
authors.lastname: Nance
authors.forename: Edward
authors.initials: E
authors.lastname: Drasby
authors.forename: Stuart
authors.initials: S
authors.lastname: Isaacson
authors.forename: David J
authors.initials: DJ
authors.lastname: Burn
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Chinnery
authors.forename: Peter P
authors.initials: PP
authors.lastname: Pramstaller
authors.forename: Jomana
authors.initials: J
authors.lastname: Al-Hinti
authors.forename: Anette T
authors.initials: AT
authors.lastname: Moller
authors.forename: Karen
authors.initials: K
authors.lastname: Ostergaard
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Sherman
authors.forename: Richard
authors.initials: R
authors.lastname: Roxburgh
authors.forename: Barry
authors.initials: B
authors.lastname: Snow
authors.forename: John T
authors.initials: JT
authors.lastname: Slevin
authors.forename: Franca
authors.initials: F
authors.lastname: Cambi
authors.forename: James F
authors.initials: JF
authors.lastname: Gusella
authors.forename: Richard H
authors.initials: RH
authors.lastname: Myers
mesh_terms: D017668:Age of Onset; D000368:Aged; D015331:Cohort Studies; D030541:Databases, Genetic; D051959:ELAV Proteins / Q000235:genetics* / Q000502:physiology; D000067779:ELAV-Like Protein 4; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D051959:ELAV Proteins; D000067779:ELAV-Like Protein 4; C498010:ELAVL4 protein, human