title: Sopungyangjae-tang inhibits development of dermatitis in nc/nga mice.
abstract: Sopungyangjae-Tang (SYT) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study was to confirm whether or not SYT has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SYT was administered orally to Nc/Nga mice, which led to the remarkable suppression of the development of dermatitis, as determined by a histological examination and the serum IgE levels. Moreover, SYT inhibited the production of thymus- and activation-regulated chemokine (TARC) and its mRNA expression in a keratinocyte cell line, HaCaT, which had been stimulated with tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Activation of the nuclear factor-kappaB (NF-kappaB) or activator protein-1 (AP-1) is one of the key steps in the signaling pathways mediating induction of TARC. In this study, SYT selectively suppressed NF-kappaB activation, which may be essential for TARC expression in TNF-alpha/IFN-gamma treated keratinocytes. The inhibitory effect of SYT on NF-kappaB activation and TARC production might be associated with the anti-dermatitic effects of SYT.
authors.affiliation: BK21 Project Team, College of Pharmacy and Department of Pathology, College of Medicine, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759, Department of Prescription, College of Oriental Medicine, Daegu Haany University, Daegu 706-060 and College of Biomedical Laboratory Science, Konyang University, Daejeon, South Korea.
authors.forename: Yuba Raj
authors.initials: YR
authors.lastname: Pokharel
authors.forename: Sung Chul
authors.initials: SC
authors.lastname: Lim
authors.forename: Sang Chan
authors.initials: SC
authors.lastname: Kim
authors.forename: Tae-Hwe
authors.initials: TH
authors.lastname: Heo
authors.forename: Hoo Kyun
authors.initials: HK
authors.lastname: Choi
authors.forename: Keon Wook
authors.initials: KW
authors.lastname: Kang