title: Two cases of trisomy 19 as a sole chromosomal abnormality in myeloid disorders.
abstract: Trisomy 19 is frequently encountered in cases of chronic myeloid leukemia (CML) as a secondary abnormality: however, trisomy 19 rarely occurs as a sole chromosomal abnormality and, to date, it has only been reported in 48 hematopoietic malignancies, 1 case of adenocarcinoma and 1 case of astrocytic tumor. Here, we report two additional cases of trisomy 19 as a sole karyotypic aberration in myeloid malignancies. One of these cases involved a 6-month-old male who was diagnosed with acute myeloid leukemia minimally differentiated. His karyotype was 47,XY,+19[20]. He expired 5 days after diagnosis. Another case occurred in an 80-yr-old female who had refractory anemia with excess blasts. Her karyotype was 47,XX,+19[16]/46,XX[4]. Four months later, her peripheral blood smears suggested that the disease had progressed, but she refused further evaluation. Based on a review of the existing literature and the results of this report, trisomy 19 not only as a secondary abnormality but also as a sole karyotypic aberration is strongly associated with myeloid disorder; however, it is not preferentially found in specific FAB subgroups of myelodysplasic syndrome or acute myeloid leukemia.
authors.affiliation: Department of Laboratory Medicine, Yeungnam University College of Medicine, Daegu, Korea.
authors.forename: Soon Il
authors.initials: SI
authors.lastname: Jung
authors.forename: Hee Soon
authors.initials: HS
authors.lastname: Cho
authors.forename: Chae Hoon
authors.initials: CH
authors.lastname: Lee
authors.forename: Kyong Dong
authors.initials: KD
authors.lastname: Kim
authors.forename: Jung Ok
authors.initials: JO
authors.lastname: Ha
authors.forename: Min-Kyoung
authors.initials: MK
authors.lastname: Kim
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Lee
authors.forename: Myung Soo
authors.initials: MS
authors.lastname: Hyun
mesh_terms: D000208:Acute Disease; D000369:Aged, 80 and over; D000753:Anemia, Refractory / Q000175:diagnosis* / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D014314:Trisomy