Electron transfer-initiated Diels-Alder cycloadditions of 2'-hydroxychalcones.
An efficient approach to cyclohexenyl chalcones employing highly electron rich 2'-hydroxychalcone dienophiles via electron transfer-initiated Diels-Alder cycloaddition is described. Using the methodology, the total synthesis of nicolaiodesin C has been accomplished.
Cong
Huan
H
Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, Boston, Massachusetts 02215, USA.
Ledbetter
Dustin
D
Rowe
Gerard T
GT
Caradonna
John P
JP
Porco
John A
JA
D000107:Acetylation; D002070:Butadienes / Q000737:chemistry*; D047188:Chalcones / Q000138:chemical synthesis*; D003500:Cyclization; D004583:Electrons
D002070:Butadienes; D047188:Chalcones; C471531:nicolaioidesin C