title: Evaluation of nutritional status in patients undergoing hematopoietic SCT.
abstract: The aims of this study were to establish the nutritional status of patients during hematopoietic SCT (HSCT) and to determine if body mass index (BMI) is a valid indicator of nutritional status in this population when compared with nitrogen balance (NB). In total, 50 patients were enrolled (mean age: 25.7+/-9.0 years). Patients (14%) were underweight (BMI<18.5 kg/m(2)), 58% in a normal BMI (between 18.5 and 24.9 kg/m(2)) and 28% were overweight or obese (BMI >or= 25 kg/m(2)). NB dropped after transplantation and increased from days +5 to +20 after transplantation (P=0.006). There was a significant negative relationship between patients' BMI and time to engraftment (r=-0.45, P=0.001). Engraftment of underweight patients was 3.0 days (P=0.002) and 4.0 days (P<0.001) later than in normal and overweight or obese patients, respectively. There was no significant correlation between NB before transplantation and time to engraftment (r=-0.22, P=0.16). The results of this study demonstrate that patients undergoing HSCT may have suboptimal nutritional status and that pre-HSCT-BMI rather than NB may have a greater correlation in HSCT patients with the time of engraftment. Therefore, it may be useful to consider patient's BMI before transplantation for earlier engraftment time.
authors.affiliation: Faculty of Pharmacy, Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Hadjibabaie
authors.forename: M
authors.initials: M
authors.lastname: Iravani
authors.forename: M
authors.initials: M
authors.lastname: Taghizadeh
authors.forename: A
authors.initials: A
authors.lastname: Ataie-Jafari
authors.forename: A R
authors.initials: AR
authors.lastname: Shamshiri
authors.forename: S A
authors.initials: SA
authors.lastname: Mousavi
authors.forename: K
authors.initials: K
authors.lastname: Alimoghaddam
authors.forename: S
authors.initials: S
authors.lastname: Hosseini
authors.forename: A
authors.initials: A
authors.lastname: Ghavamzadeh
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D002149:Energy Intake; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D052016:Mucositis / Q000209:etiology; D009584:Nitrogen / Q000378:metabolism; D009752:Nutritional Status; D009765:Obesity / Q000453:epidemiology; D050177:Overweight / Q000453:epidemiology; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects; D015203:Reproducibility of Results; D013851:Thinness / Q000453:epidemiology; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D009584:Nitrogen