Complete sequence of the genome of avian paramyxovirus type 2 (strain Yucaipa) and comparison with other paramyxoviruses.
The complete RNA genome sequence of avian paramyxovirus (APMV) serotype 2, strain Yucaipa isolated from chicken has been determined. With genome size of 14,904 nucleotides (nt), strain Yucaipa is consistent with the "rule of six" and is the smallest virus reported to date among the members of subfamily Paramyxovirinae. The genome contains six non-overlapping genes in the order 3'-N-P/V-M-F-HN-L-5'. The genes are flanked on either side by highly conserved transcription start and stop signals and have intergenic sequences varying in length from 3 to 23nt. The genome contains a 55nt leader sequence at 3' end and a 154nt trailer sequence at 5' end. Alignment and phylogenetic analysis of the predicted amino acid sequences of strain Yucaipa proteins with the cognate proteins of viruses of all of the five genera of family Paramyxoviridae showed that APMV-2 strain Yucaipa is more closely related to APMV-6 than APMV-1.
Subbiah
Madhuri
M
Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742 USA.
Xiao
Sa
S
Collins
Peter L
PL
Samal
Siba K
SK
D000595:Amino Acid Sequence; D000818:Animals; D018109:Avulavirus / Q000145:classification / Q000235:genetics* / Q000254:growth & development; D001483:Base Sequence / Q000235:genetics*; D002417:Cattle; D002460:Cell Line; D045744:Cell Line, Tumor; D002642:Chick Embryo; D002645:Chickens; D002522:Chlorocebus aethiops; D006224:Cricetinae; D004285:Dogs; D016679:Genome, Viral / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010252:Paramyxoviridae / Q000235:genetics*; D010802:Phylogeny; D011817:Rabbits; D016415:Sequence Alignment; D014709:Vero Cells; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics
D014764:Viral Proteins