Review: Deoxyglucose compounds labeled with isotopes different from 18-fuoride: is there a future in clinical practice?
There are several radionuclide-labeled derivatives of deoxyglucose (DG) that have been developed including 2-fluro-deoxyglucose, ethylenedicysteine-deoxyglucose, diethylenetriaminepentaacetate-deoxyglucose, N-(2'-hydroxybenzyl)-2-amino-2-deoxy-D-glucose, and methyl D-glucoside that were synthesized and successfully labeled in high labeling fields. The former 4 were used for tumor imaging and methyl-D-glucoside for the diagnosis and the monitoring of the functional status of renal tubules. These derivatives are suitable for imaging examinations when labeled with either fluorine-18 (18F), technetium-99m (99mTc), carbon-11 (11C), or gallium-68 (68Ga). These compounds are suitable both for imaging and for therapy if labeled with rhenium-188 (188Re). In the area of molecular imaging of nuclear medicine, derivatives of radionuclide-labeled deoxyglucose will become an important tool for the diagnosis and carcinoma treatment in the clinic.
Xiong
Qing-Feng
QF
Department of Nuclear Medicine, Affiliated Hospital, Luzhou Medical College, Luzhou, Sichuan, China.
Chen
Yue
Y
D000818:Animals; D003847:Deoxyglucose / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D003952:Diagnostic Imaging / Q000379:methods; D005462:Fluorine Radioisotopes / Q000494:pharmacology*; D019788:Fluorodeoxyglucose F18 / Q000494:pharmacology; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D004369:Pentetic Acid / Q000494:pharmacology; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods; D011868:Radioisotopes / Q000737:chemistry / Q000494:pharmacology; D012211:Rhenium / Q000494:pharmacology; D013667:Technetium / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods
D005462:Fluorine Radioisotopes; D011868:Radioisotopes; D019788:Fluorodeoxyglucose F18; D012211:Rhenium; D013667:Technetium; D004369:Pentetic Acid; D003847:Deoxyglucose