title: The epidemiology of human rotavirus associated with diarrhoea in Kenyan children: a review.
abstract: Rotavirus gastroenteritis still remains a major cause of morbidity and mortality among young children in developing countries, with approximately 150,000-200,000 deaths occurring annually in sub-Saharan Africa. We reviewed papers published over the last 30 years on the epidemiology of rotavirus diarrhoea among the hospitalized and out-patient children in Kenya. The analysis shows rotavirus prevalence of 6-56% with diarrhoea occurring throughout the year and generally exhibiting distinct peaks during the dry months. Among the common genotype, G1 was the most predominant up to the year 2002 but more recently there has been an emergence of genotype G9 as the most predominant genotype and to a less extent G8. It is important to continue rotavirus surveillance in Kenya to determine accurately the burden of rotavirus disease and the emerging new genotypes. This will assist policy makers in decision making on rotavirus vaccine introduction and determining the impact of the vaccine.
authors.affiliation: Enteric Viruses Research Group, Institute of Primate Research, P.O. Box 24481, 00502, Karen, Nairobi, Kenya.
authors.forename: Nicholas M
authors.initials: NM
authors.lastname: Kiulia
authors.forename: Rose
authors.initials: R
authors.lastname: Kamenwa
authors.forename: Grace
authors.initials: G
authors.lastname: Irimu
authors.forename: James O
authors.initials: JO
authors.lastname: Nyangao
authors.forename: Zipporah
authors.initials: Z
authors.lastname: Gatheru
authors.forename: Atunga
authors.initials: A
authors.lastname: Nyachieo
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Steele
authors.forename: Jason M
authors.initials: JM
authors.lastname: Mwenda
mesh_terms: D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology* / Q000209:etiology / Q000821:virology; D005759:Gastroenteritis / Q000453:epidemiology* / Q000209:etiology / Q000821:virology; D005838:Genotype; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D015995:Prevalence; D012401:Rotavirus / Q000145:classification* / Q000235:genetics; D012400:Rotavirus Infections / Q000150:complications / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control; D022243:Rotavirus Vaccines / Q000235:genetics / Q000276:immunology; D012703:Serotyping
chemical_list: D022243:Rotavirus Vaccines