title: Efficacy of guided tissue regeneration in the management of through-and-through lesions following surgical endodontics: a preliminary study.
abstract: The purpose of this prospective study was to assess the outcome of periradicular surgery with or without guided tissue regeneration (GTR) for the treatment of through-and-through lesions. Thirty-four teeth were included according to specific selection criteria. In the test group (using GTR), after root-end filling, the defects were filled with anorganic bovine bone and covered with a resorbable collagen membrane. Healing was assessed according to specific criteria and graded as successful, doubtful, or failed. In the control group, neither grafts nor membranes were used. After 1 year, 31 teeth were evaluated. Of these, 22 (71%) healed successfully, 6 (19%) showed doubtful healing, and 2 were recorded as failures. The outcomes of the defects treated with GTR (88% successful) were significantly better than those of the control group (57% successful). The present study showed that the use of GTR associated with anorganic bovine bone in the treatment of through-and-through lesions may positively affect the healing process.
authors.affiliation: Section of Endodontics, Department of Health Technologies, Galeazzi Institute, University of Milano, Milan, Italy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Taschieri
authors.forename: Massimo
authors.initials: M
authors.lastname: Del Fabbro
authors.forename: Tiziano
authors.initials: T
authors.lastname: Testori
authors.forename: Massimo
authors.initials: M
authors.lastname: Saita
authors.forename: Roberto
authors.initials: R
authors.lastname: Weinstein
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D001047:Apicoectomy; D001857:Bone Matrix / Q000637:transplantation; D018786:Bone Substitutes / Q000627:therapeutic use; D003094:Collagen; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008439:Maxillary Diseases / Q000601:surgery*; D008567:Membranes, Artificial; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D010483:Periapical Diseases / Q000601:surgery*; D011446:Prospective Studies; D012184:Retrograde Obturation; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen