title: Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension.
abstract: To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.
authors.affiliation: Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, 14220 Prague, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Pravenec
authors.forename: Paul C
authors.initials: PC
authors.lastname: Churchill
authors.forename: Monique C
authors.initials: MC
authors.lastname: Churchill
authors.forename: Ondrej
authors.initials: O
authors.lastname: Viklicky
authors.forename: Ludmila
authors.initials: L
authors.lastname: Kazdova
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Aitman
authors.forename: Enrico
authors.initials: E
authors.lastname: Petretto
authors.forename: Norbert
authors.initials: N
authors.lastname: Hubner
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Wallace
authors.forename: Heike
authors.initials: H
authors.lastname: Zimdahl
authors.forename: Vaclav
authors.initials: V
authors.lastname: Zidek
authors.forename: Vladimir
authors.initials: V
authors.lastname: Landa
authors.forename: Joseph
authors.initials: J
authors.lastname: Dunbar
authors.forename: Anil
authors.initials: A
authors.lastname: Bidani
authors.forename: Karen
authors.initials: K
authors.lastname: Griffin
authors.forename: Nathan
authors.initials: N
authors.lastname: Qi
authors.forename: Martina
authors.initials: M
authors.lastname: Maxova
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kren
authors.forename: Petr
authors.initials: P
authors.lastname: Mlejnek
authors.forename: Jiaming
authors.initials: J
authors.lastname: Wang
authors.forename: Theodore W
authors.initials: TW
authors.lastname: Kurtz
mesh_terms: D000818:Animals; D018955:CD36 Antigens / Q000235:genetics*; D006973:Hypertension / Q000235:genetics*; D007668:Kidney / Q000378:metabolism; D040641:Quantitative Trait Loci; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D018955:CD36 Antigens