Primary CNS lymphoma and HLA class I and II alleles in a German cohort of immunocompetent patients.
Human leukocyte antigens (HLA) are involved in the regulation of immune response to infection and in malignant transformation. Several HLA alleles are associated with immunological or malignant diseases. The aim of the present study was to evaluate a potential association of HLA class I and II alleles with primary central nervous system lymphoma (PCNSL) in immunocompetent patients. We therefore analyzed particular HLA-A, HLA-B and HLA-DRB1 alleles in 82 PCNSL patients and compared the data to those in 327 population controls. No significant difference between these two groups was found using Pearson's chi(2) test. These data do not support the hypothesis that HLA alleles play a major role in the pathogenesis of PCNSL.
Kurzwelly
Delia
D
Clinical Neurooncology Unit, Department of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.
Müller
Claudia A
CA
Korfel
Agnieszka
A
Thiel
Eckhard
E
Linnebank
Michael
M
Weller
Michael
M
Herrlinger
Ulrich
U
D000293:Adolescent; D000328:Adult; D000368:Aged; D016543:Central Nervous System Neoplasms / Q000235:genetics*; D017327:Clinical Trials, Phase IV as Topic; D005260:Female; D020022:Genetic Predisposition to Disease; D005858:Germany; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D044465:White People
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II