title: Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction.
abstract: Coronary artery disease (CAD) and myocardial infarction (MI) have a genetic basis, but the precise genetic underpinning remains controversial. Recently, an association of the LRP8 R952Q polymorphism (rs5174) with familial premature CAD/MI was reported. We analysed rs5174 (or the perfect proxy rs5177) in 1,210 patients with familial MI and 1,015 controls from the German MI Family study, in 1,926 familial CAD (1,377 with MI) patients and 2,938 controls from the Wellcome Trust Case Control Consortium (WTCCC) MI/CAD cohort, in 346 CAD patients and 351 controls from the AtheroGene study and in 295 men with incident CAD and 301 controls from the Prospective Epidemiological Study of MI study and found no evidence for association in any of the populations studied. In the WTCCC and the German MI Family studies, additional single-nucleotide polymorphisms in the LRP8 gene were analysed and displayed no evidence for association either.
authors.affiliation: Medizinische Klinik II, Universität zu Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Lieb
authors.forename: Tanja
authors.initials: T
authors.lastname: Zeller
authors.forename: Massimo
authors.initials: M
authors.lastname: Mangino
authors.forename: Anika
authors.initials: A
authors.lastname: Götz
authors.forename: Peter
authors.initials: P
authors.lastname: Braund
authors.forename: Juergen J
authors.initials: JJ
authors.lastname: Wenzel
authors.forename: Christian
authors.initials: C
authors.lastname: Horn
authors.forename: Carole
authors.initials: C
authors.lastname: Proust
authors.forename: Patrick
authors.initials: P
authors.lastname: Linsel-Nitschke
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: Petra
authors.initials: P
authors.lastname: Bruse
authors.forename: Dominique
authors.initials: D
authors.lastname: Arveiler
authors.forename: Inke R
authors.initials: IR
authors.lastname: König
authors.forename: Jean
authors.initials: J
authors.lastname: Ferrières
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Balmforth
authors.forename: Alun
authors.initials: A
authors.lastname: Evans
authors.forename: Pierre
authors.initials: P
authors.lastname: Ducimetière
authors.forename: Francois
authors.initials: F
authors.lastname: Cambien
authors.forename: Christian
authors.initials: C
authors.lastname: Hengstenberg
authors.forename: Klaus
authors.initials: K
authors.lastname: Stark
authors.forename: Alistair S
authors.initials: AS
authors.lastname: Hall
authors.forename: Heribert
authors.initials: H
authors.lastname: Schunkert
authors.forename: Stefan
authors.initials: S
authors.lastname: Blankenberg
authors.forename: Nilesh J
authors.initials: NJ
authors.lastname: Samani
authors.forename: Jeanette
authors.initials: J
authors.lastname: Erdmann
authors.forename: Laurence
authors.initials: L
authors.lastname: Tiret
mesh_terms: D003324:Coronary Artery Disease / Q000235:genetics*; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D005858:Germany; D006801:Humans; D026502:LDL-Receptor Related Proteins; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018110:Receptors, Lipoprotein / Q000235:genetics*
chemical_list: D026502:LDL-Receptor Related Proteins; D018110:Receptors, Lipoprotein; C098773:low density lipoprotein receptor-related protein 8