title: Longitudinal MRI evaluations of human global cortical thickness over minutes to weeks.
abstract: Magnetic resonance imaging (MRI) was used to evaluate within-subject variability in global mean cortical thickness over test-retest intervals of minutes-weeks in five healthy adults. Within-subject measures of global mean thickness were consistent over these intervals. Test-retest assessments of absolute thickness differences and percent thickness differences indicated variations of, respectively, < or =0.05-0.06 mm and < or =+/-1.9-2.3%. There have been few evaluations of normal within-subject variations in cortical thickness. The present results suggest that within-subject variability in global mean cortical thickness can be low over test-retest intervals of minutes-weeks, and that longitudinal scans can establish useful baseline estimates of variability from which to assess changes due to injury, disease, or other experiences.
authors.affiliation: Department of Neuroscience, University of Toledo Medical Center, Toledo, OH 43614, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: William
authors.initials: W
authors.lastname: Bauer
authors.forename: Nicolas
authors.initials: N
authors.lastname: Chiaia
authors.forename: Michael
authors.initials: M
authors.lastname: Dennis
authors.forename: Mischka
authors.initials: M
authors.lastname: Gerken
authors.forename: Jacob
authors.initials: J
authors.lastname: Hummel
authors.forename: John
authors.initials: J
authors.lastname: Kane
authors.forename: Cynthia
authors.initials: C
authors.lastname: Kenmuir
authors.forename: Sadik
authors.initials: S
authors.lastname: Khuder
authors.forename: Richard
authors.initials: R
authors.lastname: Lane
authors.forename: Richard
authors.initials: R
authors.lastname: Mooney
authors.forename: Peter
authors.initials: P
authors.lastname: Bazeley
authors.forename: Vania
authors.initials: V
authors.lastname: Apkarian
authors.forename: John
authors.initials: J
authors.lastname: Wall
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D013997:Time Factors