title: Intradural saccular aneurysms treated by Guglielmi detachable bare coils at a single institution between 1993 and 2005: clinical long-term follow-up for a total of 1810 patient-years in relation to morphological treatment results.
abstract: OBJECTIVE
  The aim of this study was to analyze the clinical results of Guglielmi detachable bare coil (GDC) embolization of intradural saccular aneurysms (AAs) at a single center and to relate the morphological results at various time points to the clinical situation.
  
  
  METHODS
  All intradural saccular AAs treated with GDCs between 1993 and April 2005 were prospectively entered into a database completed by retrospective analysis of charts and images and a long-term clinical outcome questionnaire. In 413 consecutive patients, there were 466 treated AAs, of which 68.7% were ruptured and 31.1% were unruptured.
  
  
  RESULTS
  The periprocedural thromboembolic event rate, retreatment procedures included, was 5.4%, causing permanent neurologic deficits in 2.2% of patients. One patient (0.2%) bled during a mean+/-SD clinical follow-up of 64.3+/-39.9 months (93 AAs were followed up for >8 years and 45 AAs were followed up for >10 years) for a total of 1810 patient-years. The modified Rankin Scale score was 0 in 54.7%, 1 in 21.0%, 2 in 12.1%, 3 in 7.1%, 4 in 2.1%, 5 in 0.3%, and 6 (death from unrelated causes) in 2.7% of patients. If an aneurysm, with or without a remnant, was unchanged for 12 months, then the risk for future morphological loss was 4.8%, whereas if an aneurysm showed a morphological loss during the earlier 12-month interval, the risk for additional late loss was 38.3% (P<0.001, odds ratio=12.4).
  
  
  CONCLUSIONS
  Embolization of saccular AAs entails a prolonged management period. A stable angiographic result during a 12-month interval predicts a low risk for morphological deterioration. This regimen, aiming for a stable angiographic result rather than complete aneurysm occlusion, gives a low rebleed rate and excellent clinical long-term results.
authors.affiliation: Service de Neuroradiologie Vasculaire Diagnostique et Thérapeutique, CHU de Bicêtre, Le Kremlin-Bicêtre, France. staffan.holmin@karolinska.se
authors.forename: Staffan
authors.initials: S
authors.lastname: Holmin
authors.forename: Timo
authors.initials: T
authors.lastname: Krings
authors.forename: Augustin
authors.initials: A
authors.lastname: Ozanne
authors.forename: Jan-Patrick
authors.initials: JP
authors.lastname: Alt
authors.forename: Ann
authors.initials: A
authors.lastname: Claes
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Zhao
authors.forename: Hortensia
authors.initials: H
authors.lastname: Alvarez
authors.forename: Georges
authors.initials: G
authors.lastname: Rodesch
authors.forename: Pierre
authors.initials: P
authors.lastname: Lasjaunias
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging / Q000628:therapy; D002533:Cerebral Angiography; D016208:Databases, Factual; D004388:Dura Mater; D004621:Embolization, Therapeutic / Q000295:instrumentation* / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome