title: The relationship of plasminogen activator inhibitor-1 levels to the ST deviation pattern of acute myocardial infarction.
abstract: OBJECTIVE
  Myocardial infarction (MI) may be classified as ST elevation MI (STEMI) or non-ST elevation MI (NSTEMI). Procoagulants such as plasminogen activator inhibitor-1 (PAI-1) as well as markers of inflammation such as C-reactive protein (CRP), serum amyloid A (SAA) and interleukin-6 (IL-6) are elevated in acute coronary syndromes. However, no study has examined whether levels of these markers differ in patients with STEMI as opposed to NSTEMI. We sought to determine whether there are differences in plasma levels of PAI-1, CRP, SAA or IL-6 in patients with STEMI compared to patients with NSTEMI.
  
  
  METHODS
  Seventy-six consecutive patients presenting with acute MI (37 with STEMI and 39 with NSTEMI) were prospectively enrolled. Blood samples were obtained from patients within 6 h from presentation and plasma PAI-1, CRP, IL-6 and SAA concentrations were measured.
  
  
  RESULTS
  Plasma levels of PAI-1 were significantly higher in patients with STEMI compared to NSTEMI: 85.7 +/- 5 vs. 61.3 +/- 5 ng/ml (p < 0.001), while CRP, SAA and IL-6 levels were not significantly different between STEMI and NSTEMI patients.
  
  
  CONCLUSIONS
  Higher plasma PAI-1 levels in STEMI patients may contribute to the predilection of these patients to occlusive thrombi and STEMI.
authors.affiliation: Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. drott@012.net.il
authors.forename: David
authors.initials: D
authors.lastname: Rott
authors.forename: David
authors.initials: D
authors.lastname: Leibowitz
authors.forename: Zvezdana
authors.initials: Z
authors.lastname: Finci-Yeheskel
authors.forename: Vivian
authors.initials: V
authors.lastname: Barak
authors.forename: Tova
authors.initials: T
authors.lastname: Chajek-Shaul
authors.forename: Teddy
authors.initials: T
authors.lastname: Weiss
authors.forename: Mark
authors.initials: M
authors.lastname: Levin
authors.forename: Simcha
authors.initials: S
authors.lastname: Urieli-Shoval
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D003328:Coronary Thrombosis / Q000175:diagnosis / Q000378:metabolism; D004562:Electrocardiography; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000378:metabolism*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011237:Predictive Value of Tests; D000685:Serum Amyloid A Protein / Q000378:metabolism
chemical_list: D000209:Acute-Phase Proteins; C508600:IL6 protein, human; D015850:Interleukin-6; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein