title: Physiological effects of a lung-recruiting strategy applied during one-lung ventilation.
abstract: BACKGROUND
  One-lung ventilation (OLV) affects respiratory mechanics and ventilation/perfusion matching, reducing functional residual capacity of the ventilated lung. While the application of a lung-recruiting manoeuvre (RM) on the ventilated lung has been shown to improve oxygenation, data regarding the impact of RM on respiratory mechanics are not available.
  
  
  METHODS
  Thirteen patients undergoing lung resection in lateral decubitus were studied. During OLV, a lung-recruiting strategy consisting in a RM lasting 1 min followed by the application of positive end-expiratory pressure 5 cmH(2)O was applied to the ventilated lung. Haemodynamics, gas exchange and respiratory mechanics parameters were recorded on two-lung ventilation (TLV(baseline)), OLV before and 20 min after the RM (OLV(pre-RM), OLV(post-RM), respectively) and TLV(end). Haemodynamics parameters were also recorded during the RM.
  
  
  RESULTS
  The PaO(2)/FiO(2) ratio was 358+/-126 on TLV(baseline); it decreased to 235+/-113 on OLV(pre-RM) (P<0.01) increased to 351+/-120 on OLV(post-RM) (P<0.01 vs. OLV(pre-RM)), and remain stable thereafter. During the RM, CI decreased from 3.04+/-0.7 l/m(2) OLV(pre-RM) to 2.4+/-0.6 l/m(2) (P<0.05), and returned to baseline on OLV(post-RM) (3.1+/-0.7 l/m(2), NS vs. OLV(pre-RM)). The RM resulted in alveolar recruitment and caused a significant decrease in static elastance of the dependent lung (16.6+/-8.9 cmH(2)O/ml OLV(post-RM) vs. 22.3+/-8.1 cmH(2)O/ml OLV(pre-RM)) (P<0.01).
  
  
  CONCLUSIONS
  During OLV in lateral decubitus for thoracic surgery, application to the dependent lung a recruiting strategy significantly recruits the dependent lung, improving arterial oxygenation and respiratory mechanics until the end of surgery. However, the transient haemodynamic derangement occurring during the RM should be taken into account.
authors.affiliation: Dipartimento di Scienze Chirurgiche, Sezione di Anestesiologia e Rianimazione, Università degli Studi di Foggia, Policlinico Riuniti, Foggia, Italy. g.cinnella@unifg.it
authors.forename: G
authors.initials: G
authors.lastname: Cinnella
authors.forename: S
authors.initials: S
authors.lastname: Grasso
authors.forename: C
authors.initials: C
authors.lastname: Natale
authors.forename: F
authors.initials: F
authors.lastname: Sollitto
authors.forename: M
authors.initials: M
authors.lastname: Cacciapaglia
authors.forename: M
authors.initials: M
authors.lastname: Angiolillo
authors.forename: G
authors.initials: G
authors.lastname: Pavone
authors.forename: L
authors.initials: L
authors.lastname: Mirabella
authors.forename: M
authors.initials: M
authors.lastname: Dambrosio
mesh_terms: D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis / Q000706:statistics & numerical data; D002985:Clinical Protocols; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000502:physiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010043:Outcome and Process Assessment, Health Care; D011013:Pneumonectomy; D011187:Posture / Q000502:physiology*; D012121:Respiration, Artificial / Q000379:methods*; D012129:Respiratory Function Tests / Q000706:statistics & numerical data