[The free-radical processes and antioxidant therapy in brain ischemia].
A role of the free-radical processes and disturbances of oxidative-restorative blood homeostasis and nervous tissue in the pathogenesis of brain ischemic pathology and other diseases are reviewed. Attention is focused on the search for optimal ways of pharmacological correction of oxidative stress in the schemes of complex treatment of chronic blood circulation insufficiency and on the necessity of combined application of several antioxidants with different mechanisms of action which reciprocally potentiate each other. Experimental and clinical suppositions of the use of a-lipoic acid as one of the most studied antioxidant in the treatment of brain ischemia as well as the results of own studies on the preparation berlition which contains a-lipoic acid used in the neuroprotective therapy of chronic brain ischemia for correction of free-radical processes are discussed.
Solov'eva
E Iu
EIu
Mironova
O P
OP
Baranova
O A
OA
Bekman
E M
EM
Aseĭchev
A V
AV
Fedin
A I
AI
Azizova
O A
OA
D000368:Aged; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D005609:Free Radicals / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000037:antagonists & inhibitors; D008875:Middle Aged; D008063:Thioctic Acid / Q000494:pharmacology* / Q000627:therapeutic use*
D000975:Antioxidants; D005609:Free Radicals; D008315:Malondialdehyde; D008063:Thioctic Acid; C532845:berlition