title: Dobutamine stress cardiac magnetic resonance imaging to detect myocardial ischemia in women.
abstract: This study sought to evaluate dobutamine stress cardiac magnetic resonance imaging (DCMRI) in women with abnormal stress nuclear testing results. Women with findings on stress nuclear exams, including electrocardiography and/or perfusion, thought to require further evaluation with invasive coronary angiography were prospectively enrolled. Multiplane cine imaging was obtained at rest and at each stage of inotropic stress with atropine as needed to achieve target heart rate. DCMRI results were compared with stress nuclear and invasive cardiac catheterization results. Of 23 patients enrolled successfully, 22 completed DCMRI examination without complications. In all cases, DCMRI imaging demonstrated appropriate stress response with no ischemia despite abnormalities on stress nuclear testing. In the 18 patients who also underwent invasive coronary angiography, no significant obstructive disease was identified. DCMRI may be a useful alternative to stress nuclear examination in women; larger studies are warranted to determine its potential to more accurately predict obstructive coronary artery disease.
authors.affiliation: Davis Heart and Lung Research Institute, The Ohio State University Division of Cardiovascular Medicine, 473 West 12th Avenue, Columbus, OH 43210, USA. raman1@osu.edu
authors.forename: Subha V
authors.initials: SV
authors.lastname: Raman
authors.forename: Michael R
authors.initials: MR
authors.lastname: Donnally
authors.forename: Beth
authors.initials: B
authors.lastname: McCarthy
mesh_terms: D002316:Cardiotonic Agents; D003937:Diagnosis, Differential; D004280:Dobutamine; D005080:Exercise Test / Q000379:methods; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis*; D015203:Reproducibility of Results
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine