title: Outsmarting the host: bacteria modulating the immune response.
abstract: Pathogenic bacteria and their hosts have had a two-way conversation for millions of years. This interaction has led to many measure/counter-measure responses by the host and bacteria. The host immune response has developed many mechanisms to neutralize and remove pathogen bacteria. In turn pathogenic bacteria have developed mechanisms to alter and evade the host immune response. We will review some of the mechanisms utilized by bacteria to accomplish this goal. We will also examine the current state of understanding of Francisella tularensis mediated immune evasion.
authors.affiliation: Department of Microbiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7290, USA.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Woolard
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Frelinger
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D001419:Bacteria / Q000276:immunology* / Q000472:pathogenicity; D001427:Bacterial Toxins / Q000276:immunology / Q000378:metabolism; D005604:Francisella tularensis / Q000276:immunology / Q000472:pathogenicity; D054884:Host-Pathogen Interactions / Q000276:immunology*; D007110:Immunity, Active; D007113:Immunity, Innate; D016753:Interleukin-10 / Q000276:immunology / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D010588:Phagosomes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D050791:STAT Transcription Factors / Q000276:immunology / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism / Q000382:microbiology
chemical_list: D001427:Bacterial Toxins; D008070:Lipopolysaccharides; D050791:STAT Transcription Factors; D016753:Interleukin-10