title: A two-stage neural spiking model of visual contrast detection in perimetry.
abstract: Perimetry is a commonly used clinical test for visual function, limited by high variability. The sources of this variability need to be better understood. In this paper, we investigate whether noise intrinsic to neural firing could explain the variability in normal subjects. We present the most physiologically accurate model to date for stimulus detection in perimetry combining knowledge of the physiology of components of the visual system with signal detection theory, and show that it requires that detection be mediated by multiple cortical cells in order to give predictions consistent with psychometric functions measured in human observers.
authors.affiliation: Discoveries In Sight, Devers Eye Institute, Legacy Health System, Portland, OR 97208-3950, USA. sgardiner@deverseye.org
authors.forename: S K
authors.initials: SK
authors.lastname: Gardiner
authors.forename: W H
authors.initials: WH
authors.lastname: Swanson
authors.forename: S
authors.initials: S
authors.lastname: Demirel
authors.forename: A M
authors.initials: AM
authors.lastname: McKendrick
authors.forename: A
authors.initials: A
authors.lastname: Turpin
authors.forename: C A
authors.initials: CA
authors.lastname: Johnson
mesh_terms: D000328:Adult; D015350:Contrast Sensitivity / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D008959:Models, Neurological; D008960:Models, Psychological; D010775:Photic Stimulation / Q000379:methods; D011594:Psychometrics; D011601:Psychophysics; D012165:Retinal Ganglion Cells / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology; D017603:Signal Detection, Psychological; D014793:Visual Cortex / Q000502:physiology*; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*