title: Effects of poorly perfused peripheries on derived transit time parameters of the lower and upper limbs.
abstract: A simple and non-intrusive approach termed the pulse transit time ratio (PTTR) has recently been shown to be a potential surrogate of the ankle-brachial index (ABI). PTTR is based on the principle of PTT, which is known to be temperature-sensitive. In this study, 23 healthy adults with normally perfused peripheries and 10 with poorly perfused peripheries were recruited. No significant change in PTTR was observed between those with cold (1.287+/-0.043) and normal (1.290+/-0.027) peripheries (p>0.05). A cold periphery may cause pulse waveform changes and indirectly affect PTT owing to poor skin microcirculation, but may have a limited effect on PTTR, which is useful as an ABI alternative.
authors.affiliation: Division of Research, Singapore General Hospital, Singapore, Singapore and Biomedical and Pharmaceutical Engineering Cluster, Nanyang Technological University, Singapore, Singapore. foo.jong.yong@sgh.com.sg
authors.forename: Jong Yong A
authors.initials: JY
authors.lastname: Foo
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Wilson
authors.forename: Gordon R
authors.initials: GR
authors.lastname: Williams
authors.forename: Margaret-Anne
authors.initials: MA
authors.lastname: Harris
authors.forename: David M
authors.initials: DM
authors.lastname: Cooper
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D001794:Blood Pressure; D003080:Cold Temperature; D005260:Female; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply* / Q000503:physiopathology*; D008297:Male; D016491:Peripheral Vascular Diseases / Q000175:diagnosis / Q000503:physiopathology*; D017156:Photoplethysmography / Q000379:methods; D011673:Pulsatile Flow; D034941:Upper Extremity / Q000098:blood supply* / Q000503:physiopathology*