Synthesis and cytotoxicity of aurilide analogs.
The artificial analogs of aurilide (1), a potent cytotoxic cyclodepsipeptide of marine origin, were synthesized, and the structure-activity relationships were investigated.
Suenaga
Kiyotake
K
Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama 223-8522, Japan.
Kajiwara
Shuri
S
Kuribayashi
Satomi
S
Handa
Tomohisa
T
Kigoshi
Hideo
H
D002626:Chemistry, Pharmaceutical / Q000379:methods; D047630:Depsipeptides / Q000737:chemistry*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D010456:Peptides, Cyclic / Q000737:chemistry*; D013329:Structure-Activity Relationship
D047630:Depsipeptides; D010456:Peptides, Cyclic; C532913:aurilide