In situ synthesis of hybrid nanocomposite with highly order arranged amorphous metallic copper nanoparticle in poly(2-hydroxyethyl methacrylate) and its potential for blood-contact uses.
A hybrid consisting of a highly ordered nanostructure of metallic Cu(0) nanoparticles embedded in a poly(2-hydroxyethyl methacrylate) (pHEMA) matrix was successfully synthesized by in situ photopolymerization, followed by in situ chemical reduction. The evolution of an ordered nanostructure of Cu(0) showing a nearly amorphous nature is discussed, and it is proposed that it is due to a coupling interaction between the Cu precursor and the unpaired O of the COOR group, associated with water molecules, among pHEMA molecules. The hybrids showed a negative surface charge and considerable improvement in blood compatibility compared to neat pHEMA and the widely used biomaterial polysulfonate.
Liu
Yen-Yu
YY
Department of Materials Science and Engineering, National Chiao Tung University, 1001 Ta-hsueh Road, Hsinchu, Taiwan.
Liu
Dean-Mo
DM
Chen
San-Yuan
SY
Tung
Tsan-Hua
TH
Liu
Tse-Ying
TY
D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry; D001769:Blood / Q000378:metabolism; D003300:Copper / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry; D013499:Surface Properties
D001672:Biocompatible Materials; D008670:Metals; D008689:Methacrylates; D013451:Sulfonic Acids; D011102:Polyhydroxyethyl Methacrylate; C005044:hydroxyethyl methacrylate; D003300:Copper; D010100:Oxygen