title: [Interaction of a causative agent with associative bacteria during salmonellosis].
abstract: OBJECTIVE
  To determine a composition of gut microflora during salmonellosis and to study the modification of persistent characteristics (antilysozyme activity, ALA) of symbiotic microorganisms in associations.
  
  
  METHODS
  Bacteriologic study of feces was performed in 90 patients aged 18-39 years, which were divided to three groups: patients with salmonellosis in acute phase, reconvalescent patients, and conditionally healthy persons. Condition of gut microflorawas determined; microorganisms associated with Salmonella infection were isolated, and their influence on ALA of Salmonella was studied.
  
  
  RESULTS
  Gut microbiocenosis was more diverse in patients compared with healthy persons. Significant reduction of bifidobacteria quantity (to 10(7) CFU/g of feces and less), especially in reconvalescent period, was noted. Association between bifidoflora deficiency and excessive increase of quantity of yeast fungi was revealed. It was determined that exometabolites of indigenous anaerobic microflora (bifidobacteria) promoted decrease of ALA of Salmonella, whereas opportunistic facultatively anaerobic microorganisms (enterobacteria, staphylococci) rendered mainly stimulating effect on the ALA of Salmonella.
  
  
  CONCLUSIONS
  Obtained data reveal characteristics of bacterial interactions in associative symbiosis and provide insights about mechanisms of formation of pathobiocenosis and state of bacterial carriage.
authors.forename: O V
authors.initials: OV
authors.lastname: Bukharin
authors.forename: A V
authors.initials: AV
authors.lastname: Valyshev
authors.forename: E V
authors.initials: EV
authors.lastname: Ivanova
authors.forename: I N
authors.initials: IN
authors.lastname: Chaĭnikova
authors.forename: N B
authors.initials: NB
authors.lastname: Perunova
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001644:Bifidobacterium / Q000302:isolation & purification / Q000502:physiology*; D015169:Colony Count, Microbial; D003289:Convalescence; D005243:Feces / Q000382:microbiology; D006801:Humans; D009113:Muramidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D012475:Salmonella / Q000302:isolation & purification / Q000502:physiology*; D012480:Salmonella Infections / Q000382:microbiology* / Q000473:pathology; D013559:Symbiosis; D015003:Yeasts / Q000302:isolation & purification / Q000502:physiology*
chemical_list: D009113:Muramidase