[Identification of clinical isolates of Burkholderia cepacia and assessment of their pathogenicity in animal experiments].
In experiments on animals study of pathogenicity of 9 clinical strains of Burkholderia cepacia isolated from patients with chronic lung diseases was performed. Preliminary identification of studied strains by means of biochemical and genetic methods allowed to establish their belonging to B. cepacia species. It was determined that 6 of 9 strains are epidemiologically significant. Experiments showed that bacteria of studied strains are not able to cause infectious process in white mice and hamadryas baboons. Conclusion about appropriateness of development and use of other biological models was made.
Bondarev
V P
VP
Darmov
I V
IV
Kovtun
A L
AL
Shaginian
I A
IA
Marakulin
I V
IV
Chukhlantsev
D A
DA
Paramonov
I V
IV
D000818:Animals; D019121:Burkholderia Infections / Q000382:microbiology*; D016956:Burkholderia cepacia / Q000145:classification / Q000302:isolation & purification* / Q000472:pathogenicity*; D002908:Chronic Disease; D006801:Humans; D008171:Lung Diseases / Q000382:microbiology*; D051379:Mice; D048529:Papio hamadryas; D014774:Virulence