Rosiglitazone attenuates the cognitive deficits induced by high fat diet feeding in rats.
The present study was designed to test the hypothesis that insulin resistance plays a role in high fat diet feeding induced cognitive deficits. Rats consuming the high fat diet exhibited characteristic features of insulin resistance viz. mild hyperglycemia, hypertriglyceridemia, hypercholesterolemia, and hyperinsulinemia. Further, these rats showed a severe deficit in learning and memory. In contrast, rosiglitazone at the dose of 5 mg/kg, p.o. for 7 days prior to biochemical and behavioral testing significantly lowered the plasma glucose, triglycerides, cholesterol, and insulin levels. These animals also performed better on Morris water maze task, suggesting improved spatial memory. Our data demonstrate that the insulin sensitizers can overcome the cognitive deficits arising from high fat diet feeding, which may be in part mediated through the development of peripheral insulin resistance.
Pathan
Asif R
AR
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), S A S Nagar, Punjab, India.
Gaikwad
Anil Bhanudas
AB
Viswanad
Bhoomi
B
Ramarao
Poduri
P
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001786:Blood Glucose / Q000187:drug effects; D003071:Cognition / Q000187:drug effects*; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D006943:Hyperglycemia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000523:psychology; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000523:psychology; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D047495:PPAR gamma / Q000819:agonists; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology*; D013997:Time Factors
D001786:Blood Glucose; D004041:Dietary Fats; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D047495:PPAR gamma; D045162:Thiazolidinediones; D000077154:Rosiglitazone