Brominated diterpenes with antibacterial activity from the red alga Sphaerococcus coronopifolius.
Four new brominated diterpenes (1, 2, 4, 5), along with two previously reported metabolites (3, 6), were isolated from the organic extract of Sphaerococcus coronopifolius, collected in Palaiokastritsa Bay at the west coast of Corfu Island. The structures of the new products, as well as their relative configuration, were established by means of spectroscopic data analyses, including 2D NMR experiments. The isolated metabolites were evaluated for their antibacterial activity against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) with MICs in the range 0.5-128 microg/mL.
Smyrniotopoulos
Vangelis
V
Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
Vagias
Constantinos
C
Rahman
M Mukhlesur
MM
Gibbons
Simon
S
Roussis
Vassilios
V
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001966:Bromine / Q000737:chemistry*; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D009682:Magnetic Resonance Spectroscopy; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D000461:Rhodophyta / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D001966:Bromine