title: Generalized peripheral lymphadenopathy in a patient treated for chronic HCV infection.
abstract: BACKGROUND
  A 62-year-old white woman was admitted to hospital with a 2-month history of progressive, painless, left supraclavicular and axillary lymph node enlargement. The patient's history was significant for chronic HCV infection, for which she had just completed a 48-week course of treatment with pegylated interferon alpha (180 microg once weekly) plus ribavirin (1,000 mg daily). She attained an end-of-treatment response and subsequent qualitative measurement of HCV RNA confirmed a sustained virological response. The onset of progressive painless lymph node enlargement had been noted by the patient during the last 2 weeks of her treatment for HCV.
  
  
  METHODS
  Physical examination, otorhinolaryngological examination, laboratory investigations (including complete blood counts, liver function tests and serological tests), mammography, thyroid and abdominal ultrasound, CT scans, abdominal MRI, upper gastrointestinal endoscopy, colonoscopy, supraclavicular lymph node biopsy, (67)Ga scintigraphy and bronchoalveolar lavage.
  
  
  METHODS
  Granulomatous lymphadenitis of uncertain etiology with sarcoid-type and tuberculoid-type granulomas.
  
  
  RESULTS
  Standard antituberculosis treatment with isoniazid, rifampicin, pyrazinamide and ethambutol for 2 months, followed by isoniazid and rifampicin for 7 months.
authors.affiliation: Gastroenterology and Hepatology Division, Hospital Santa Maria, Lisbon, Portugal. carlosnferreira@hotmail.com
authors.forename: Carlos Noronha
authors.initials: CN
authors.lastname: Ferreira
authors.forename: Elidio R
authors.initials: ER
authors.lastname: Barjas
authors.forename: Luis A
authors.initials: LA
authors.lastname: Correia
authors.forename: Luis
authors.initials: L
authors.lastname: Tavares
authors.forename: Cristina
authors.initials: C
authors.lastname: Ferreira
authors.forename: Fatima L
authors.initials: FL
authors.lastname: Serejo
authors.forename: Miguel Carneiro
authors.initials: MC
authors.lastname: de Moura
authors.forename: Estela
authors.initials: E
authors.lastname: Monteiro
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D002968:Clavicle; D003937:Diagnosis, Differential; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008198:Lymph Nodes; D008199:Lymphadenitis / Q000188:drug therapy* / Q000473:pathology*; D008875:Middle Aged; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000175:diagnosis
chemical_list: D000995:Antitubercular Agents