Beyerane derivatives and a sesquiterpene dimer from Japanese Cypress (Chamaecyparis obtusa).
In the course of studies on biological active constituents from woody plants, we previously reported the isolation of many lignan derivatives as neurite outgrowth-promoting compounds from an ethyl acetate soluble fraction of Japanese Cypress (Chamaecyparis obtusa). Further chemical investigation on the residual parts of the ethyl acetate soluble fraction of a methanol extract of Japanese Cypress resulted in the isolation of four new beyerene type derivatives and a novel sesquiterpene dimer formed between cryptomeridiol and hinokiic acid. Their structures were elucidated as 18-O-(Z)-p-coumaroylbeyer-15-ene-18-ol (1), 18-O-(E)-p-coumaroylbeyer-15-ene-18-ol (2), 18-O-(E)-p-coumaroylbeyer-15-ene-11beta,18-diol (3), 18-O-(Z)-p-coumaroylbeyer-15-ene-11beta,18-diol (4) and ent-cryptomeridiol-4-yl-hinokiiate (5) by (1)H-NMR, (13)C-NMR, 2D-NMR, and HR-MS spectral analysis.
Gao
Hui Yuan
HY
School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenhe Shenyang, PR China.
Wu
Li Jun
LJ
Muto
Norio
N
Fuchino
Hiroyuki
H
Nakane
Takahisa
T
Shirota
Osamu
O
Sano
Toshikazu
T
Kuroyanagi
Masanori
M
D029780:Chamaecyparis / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
D004224:Diterpenes; D012717:Sesquiterpenes