title: [A case of chronic tophaceous with a continuous polyarthritis and joint deformity caused by uncontrolled hyperuricemia].
abstract: A 56-year-old woman was admitted to our hospital in April 2007 due to a history of polyarthralgia. In 1999, She had been diagnosed as having gout by monoarthritis of the first metatarsophalangeal joint. She was treated with only cholchine. Subsequently she repeatedly got acute attack once a year. In 2006, episodic monoarthritis became to be continuous polyarthritis. Laboratory examination at admission showed remarkable hyperuricemia. At 3 day after hospitalization, she experienced acute attack and high fever. Diagnosis of chronic gout was confirmed by the identification of monosodium urate crystals in the synovial fluid. Her symptom improved by a treatment with dexamethasone 4 mg/day i.m. and cholchine, and did not experience acute attack for 5 months. We suggest that prophylactic administration of cholchine is beneficial in refractory chronic gout patient.
authors.affiliation: Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Kawashiri
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
authors.forename: Naoki
authors.initials: N
authors.lastname: Iwamoto
authors.forename: Keita
authors.initials: K
authors.lastname: Fujikawa
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Aramaki
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Ichinose
authors.forename: Makoto
authors.initials: M
authors.lastname: Kamachi
authors.forename: Mami
authors.initials: M
authors.lastname: Tamai
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ida
authors.forename: Tomoki
authors.initials: T
authors.lastname: Origuchi
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
mesh_terms: D001168:Arthritis / Q000209:etiology*; D003078:Colchicine / Q000627:therapeutic use; D005260:Female; D006073:Gout / Q000150:complications* / Q000188:drug therapy; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D033461:Hyperuricemia / Q000150:complications*; D008875:Middle Aged
chemical_list: D006074:Gout Suppressants; D003078:Colchicine