Reduced interleukin-17 expression of Burkholderia pseudomallei-infected peripheral blood mononuclear cells of diabetic patients.
Burkholderia pseudomallei is the causative agent of melioidosis. One of the main risk factors for B. pseudomallei infection in endemic areas is diabetes mellitus. The present study investigated IL-17 mRNA and protein expression by peripheral blood mononuclear cells in response to B. pseudomallei infection in 10 diabetic patients in comparison to 10 healthy blood donors. The IL-17 expression in diabetic patients was significantly lower (p < 0.05) than in the controls. However, IL-23 mRNA expression of the 2 groups was comparable. The present findings suggest that melioidosis affects T cell IL-17 production and that patients with diabetes mellitus have a defective IL-17 production in response to this type of infection.
Pongcharoen
Sutatip
S
Department of Medicine, Faculty of Medicine, Naresuan University, Thailand.
Ritvirool
Pannika Niumsup
PN
Sanguansermsri
Donruedee
D
Chanchan
Pairat
P
Jienmongkol
Poj
P
Butkhamchot
Puntharee
P
Warnnissorn
Prateep
P
Banchuin
Napatawn
N
Sirisinha
Stitaya
S
D000328:Adult; D016957:Burkholderia pseudomallei / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000097:blood* / Q000235:genetics; D053759:Interleukin-23 / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D008554:Melioidosis / Q000150:complications / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology
D020381:Interleukin-17; D053759:Interleukin-23; D012333:RNA, Messenger