title: Benefit of adding pioglitazone to successful statin therapy in nondiabetic patients with coronary artery disease.
abstract: BACKGROUND
  Pioglitazone added to successful statin therapy may be beneficial for coronary artery disease (CAD) patients without diabetes mellitus.
  
  
  RESULTS
  Fourteen individuals optimally treated with statin for >6 months were randomized to a pioglitazone or control group. Pioglitazone significantly improved insulin resistance, reduced high-sensitivity C-reactive protein, increased high-molecular-weight adiponectin and high-density lipoprotein cholesterol levels. Ultrasound echogenicity of carotid atheroma assessed by integrated backscatter was significantly increased by pioglitazone and correlated with adiponectin levels.
  
  
  CONCLUSIONS
  Adding pioglitazone to successful statin therapy may be an effective therapeutic strategy for patients with CAD.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University, Kumamoto, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Sugamura
authors.forename: Seigo
authors.initials: S
authors.lastname: Sugiyama
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Matsuzawa
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Nozaki
authors.forename: Yoko
authors.initials: Y
authors.lastname: Horibata
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000737:chemistry; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy; D008076:Cholesterol, HDL / Q000097:blood; D003324:Coronary Artery Disease / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D000077205:Pioglitazone; D045162:Thiazolidinediones / Q000008:administration & dosage*; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D002097:C-Reactive Protein; D000077205:Pioglitazone