title: Differences and similarities between arrhythmogenic right ventricular cardiomyopathy and athlete's heart adaptations.
abstract: BACKGROUND
  Regular intensive physical activity is associated with non-pathological changes in cardiac morphology. Differential diagnosis with arrhythmogenic right ventricular cardiomyopathy (ARVC) constitutes a frequent problem, especially in athletes showing ventricular arrhythmias with left bundle branch block morphology.
  
  
  OBJECTIVE
  To assess the different clinical and non-invasive instrumental features of the subjects affected by ARVC and by athletes.
  
  
  METHODS
  Three groups of subjects (40 ARVC patients, 40 athletes and 40 controls, mean age 27 (9) years) were examined with family and personal history, physical examination, 12-lead ECG, 24-h ECG, signal-averaged ECG and 2-D and Doppler echocardiography.
  
  
  RESULTS
  12-Lead ECG was abnormal in 62% of ARVC patients versus 7.5% of athletes and 2.5% of controls (p<0.0001). Ventricular arrhythmias and late potentials were present in 70% and 55% of ARVC subjects, respectively (vs 5% of athletes and 7.5% of controls, p<0.0001). Left ventricular parietal wall thickness and left ventricular end-diastolic diameters were significantly higher in athletes. Both athletes and ARVC patients presented a right ventricular (RV) enlargement compared with controls. Moreover, RV outflow tract, measured on parasternal long axis and at the level of aortic root, was significantly larger in ARVC patients (33.6 (4.7) mm vs 29.1 (3.4) mm and 35.6 (6.8) mm vs 30.1 (2.9) mm; p<0.0001), and RV fractional shortening and ejection fraction were significantly lower in ARVC patients compared with athletes (40 (7.9)% vs 44 (10)%; p=0.05 and 52.9 (8)% vs 59.9 (4.5)%; p<0.0001). A thickened moderator band was found to be present in similar percentage in ARVC patients and athletes.
  
  
  CONCLUSIONS
  An accurate clinical and instrumental non-invasive evaluation including echocardiography as imaging technique allows to distinguish RV alterations typical of ARVC from those detected in athletes as a consequence of intensive physical activity.
authors.affiliation: Department of Cardiology, University of Padua, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Bauce
authors.forename: G
authors.initials: G
authors.lastname: Frigo
authors.forename: G
authors.initials: G
authors.lastname: Benini
authors.forename: P
authors.initials: P
authors.lastname: Michieli
authors.forename: C
authors.initials: C
authors.lastname: Basso
authors.forename: A F
authors.initials: AF
authors.lastname: Folino
authors.forename: I
authors.initials: I
authors.lastname: Rigato
authors.forename: E
authors.initials: E
authors.lastname: Mazzotti
authors.forename: L
authors.initials: L
authors.lastname: Daliento
authors.forename: G
authors.initials: G
authors.lastname: Thiene
authors.forename: A
authors.initials: A
authors.lastname: Nava
mesh_terms: D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000503:physiopathology; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000175:diagnosis* / Q000503:physiopathology; D056352:Athletes; D002037:Bundle-Branch Block / Q000175:diagnosis* / Q000503:physiopathology; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D013177:Sports / Q000502:physiology*; D055815:Young Adult