title: Interleukin-3 (IL-3)-induced c-fos activation is modulated by Gab2-calcineurin interaction.
abstract: Interleukin-3 (IL-3) regulates cell growth by affecting various processes such as cell death, survival, and proliferation. Cues from the external environment are sensed by surface receptors, and complex signaling mechanisms arise within the cells, leading to specific functional outcomes. In this study, we demonstrate that the cytokine IL-3 induces the activation of the Ca(2+)-dependent phosphatase, calcineurin (Cn). Furthermore Cn dephosphorylates Gab2, resulting in c-fos activation and cell proliferation. We also report that there is a direct interaction between Cn and Gab2 upon IL-3 stimulation, and Akt can regulate this interaction.
authors.affiliation: Cancer Institute, NYU School of Medicine, New York University, New York, NY 10016, USA. saiju.pyarajan@mssm.edu
authors.forename: Saiju
authors.initials: S
authors.lastname: Pyarajan
authors.forename: Gabriel
authors.initials: G
authors.lastname: Matejovic
authors.forename: Joanne C
authors.initials: JC
authors.lastname: Pratt
authors.forename: Shairaz
authors.initials: S
authors.lastname: Baksh
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Burakoff
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D019703:Calcineurin / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D016923:Cell Death / Q000502:physiology; D002460:Cell Line; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D004789:Enzyme Activation / Q000502:physiology; D007377:Interleukin-3 / Q000378:metabolism*; D051379:Mice; D010750:Phosphoproteins / Q000378:metabolism*; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C490894:Gab2 protein, mouse; D007377:Interleukin-3; D010750:Phosphoproteins; D016760:Proto-Oncogene Proteins c-fos; D051057:Proto-Oncogene Proteins c-akt; D019703:Calcineurin; D002118:Calcium