title: [Preparation of tetrandrine alginate calcium sustained release gel pellets].
abstract: OBJECTIVE
  To prepare tetrandrine alginate calcium sustained release gel pellets twice daily with Eudragit RS 30D and Eudragit RL 30D.
  
  
  METHODS
  The sustained release gel pellets were prepared by fluid bed technique and release in vitro was selected as the evaluate index. The formulation was optimized by full design test based on the studies of coating factors.
  
  
  RESULTS
  The optimal coating formulation was shown at the ratio of Eudragit RS 30D and Eudragit RL 30D to 5:1, the loading weight of polymers of 45%, the plasticizer concentration of 20% and 35% talcum powder.
  
  
  CONCLUSIONS
  The perfect sustained release of tetrandrine pellets can be obtained by adjusting the ratio of Eudragit RS 30D and Eudragit RL 30D and the loading weight of polymers.
authors.affiliation: College of Chinese Traditional Medicine, Guangzhou Universtiy of Chinese Medicine, Guangzhou 510405, China. mygzhtcm@163.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.forename: Wei-zhong
authors.initials: WZ
authors.lastname: Li
authors.forename: Da-wei
authors.initials: DW
authors.lastname: Chen
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D044182:Benzylisoquinolines / Q000737:chemistry* / Q000493:pharmacokinetics; D017610:Calcium Compounds / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000493:pharmacokinetics; D004339:Drug Compounding / Q000379:methods*; D005782:Gels; D010946:Plants, Medicinal / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D031607:Stephania / Q000737:chemistry; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000180:Acrylic Resins; D044182:Benzylisoquinolines; D017610:Calcium Compounds; D003692:Delayed-Action Preparations; D005782:Gels; D011108:Polymers; D013607:Tablets; C009438:tetrandrine; C050528:Eudragit RS; C058665:Eudragit RL