Complexes of the copper-containing amine oxidase from Arthrobacter globiformis with the inhibitors benzylhydrazine and tranylcypromine.
Complexes of Arthrobacter globiformis amine oxidase (AGAO) with the inhibitors benzylhydrazine and tranylcypromine (an antidepressant drug) have been refined at 1.86 and 1.65 A resolution, respectively. Both inhibitors form covalent adducts with the TPQ cofactor. A tyrosine residue, proposed to act as a gate to the AGAO active site, is in its open conformation.
Langley
David B
DB
School of Molecular and Microbial Biosciences, University of Sydney, Australia.
Trambaiolo
Daniel M
DM
Duff
Anthony P
AP
Dooley
David M
DM
Freeman
Hans C
HC
Guss
J Mitchell
JM
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors / Q000737:chemistry*; D001173:Arthrobacter / Q000187:drug effects / Q000201:enzymology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry*; D020134:Catalytic Domain / Q000187:drug effects; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D014191:Tranylcypromine / Q000737:chemistry*
D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D006834:Hydrazines; D014191:Tranylcypromine; C006730:benzylhydrazine; D006631:Amine Oxidase (Copper-Containing)