title: Development of an effective Edwardsiella tarda vaccine for cultured turbot (Scophthalmus maximus).
abstract: Since 2004 Edwardsiella tarda has become one of the most important emerging pathogens in turbot aquaculture industry in Europe causing serious economic losses. Therefore, this study aimed to design an effective vaccination strategy to prevent edwardsiellosis in this fish species. Two vaccine formulations, an adjuvanted vaccine and an aqueous bacterin, and different routes of administration, bath and intraperitoneal injection (i.p.), were tested. The effectiveness of the different immunization strategies was evaluated in terms of relative percent survival (RPS) and antibody levels. On the basis of the results obtained we recommend the i.p. administration of a non-mineral oil adjuvanted vaccine via i.p., which confers RPS values over 90% at least 6 months post-vaccination.
authors.affiliation: Departamento de Microbiología y Parasitología, Facultad de Biología-CIBUS and Instituto de Acuicultura, Universidad de Santiago de Compostela, Santiago de Compostela, Spain. iacubact@usc.es
authors.forename: N
authors.initials: N
authors.lastname: Castro
authors.forename: A E
authors.initials: AE
authors.lastname: Toranzo
authors.forename: S
authors.initials: S
authors.lastname: Núñez
authors.forename: B
authors.initials: B
authors.lastname: Magariños
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001428:Bacterial Vaccines / Q000276:immunology*; D020609:Edwardsiella tarda / Q000502:physiology*; D004756:Enterobacteriaceae Infections / Q000276:immunology / Q000401:mortality / Q000517:prevention & control / Q000662:veterinary*; D005393:Fish Diseases / Q000276:immunology / Q000382:microbiology* / Q000401:mortality / Q000517:prevention & control*; D005398:Fisheries; D005412:Flatfishes / Q000276:immunology* / Q000382:microbiology*; D007101:Immersion; D007274:Injections, Intraperitoneal; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines