title: Acute generalised exanthematous pustulosis and toxic epidermal necrolysis induced by carbamazepine.
abstract: Acute generalised exanthematous pustulosis and Stevens-Johnson syndrome (toxic epidermal necrolysis spectrum of severe cutaneous drug reactions) are believed to have distinct underlying pathophysiologies. Our patient, a 28-year-old Chinese woman, represents the first known reported case of clinically-consistent and histologically-proven acute generalised exanthematous pustulosis and toxic epidermal necrolysis overlap induced by carbamazepine in the English literature.
authors.affiliation: Dermatology Unit, Singapore General Hospital, Outram Road, Singapore. wuzhuqing@yahoo.com
authors.forename: T K
authors.initials: TK
authors.lastname: Goh
authors.forename: S M
authors.initials: SM
authors.lastname: Pang
authors.forename: T
authors.initials: T
authors.lastname: Thirumoorthy
authors.forename: S G N
authors.initials: SG
authors.lastname: Goh
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005076:Exanthema / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000473:pathology
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine