title: [Comparative genomic hybridization analysis of nonsyndromic cleft lip with palate].
abstract: OBJECTIVE
  To identify the genetic alterations in nonsyndromic cleft lip and palate (NSCLP).
  
  
  METHODS
  Comparative genomic hybridization was applied to investigate the genomic imbalance (the gain or loss of genetic material) in 7 cases of NSCLP.
  
  
  RESULTS
  It showed that the loss of chromosome DNA copies happened in chromosome 6, 7, 10, 13, 14, 16, 20, 22 and the gain of chromosome DNA copies happened in chromosome 5, 15, 18, 19. Conclusions 13q had a high frequency (71.4%) of chromosome loss.
  
  
  CONCLUSIONS
  Abnormal chromosome DNA copies happen in all the patients with NSCLP. Most of the patients have chromosome DNA copies loss. It suggests that loss of inhibitory gene may be related to the NSCLP. The related inhibitory gene may locate in 13q.
authors.affiliation: Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Wen-Guang
authors.initials: WG
authors.lastname: Zhang
authors.forename: Shao-Jun
authors.initials: SJ
authors.lastname: Luo
authors.forename: Shao-Fang
authors.initials: SF
authors.lastname: Zhu
authors.forename: Shao-Ming
authors.initials: SM
authors.lastname: Tang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002681:China / Q000208:ethnology; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D055028:Comparative Genomic Hybridization; D004247:DNA; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007223:Infant; D009154:Mutation; D010641:Phenotype; D055815:Young Adult
chemical_list: D004247:DNA