Increase levels of apo-A1 and apo B are associated in knee osteoarthritis: lack of association with VEGF-460 T/C and +405 C/G polymorphisms.
To investigate the genotype and allele frequency of vascular endothelial growth factor gene polymorphisms in knee osteoarthritis (OA) and their relationship with disease activity and lipid profile, we enrolled 49 knee OA patients and 75 healthy subjects (HS) as a control group. Body mass index (BMI), laboratorial assessment and genotyped by polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) were studied in both groups. Disease activity was determined using Lequesne and WOMAC indexes; a P value<0.05 was considered significant. The -460 and +405 VEGF polymorphisms did not shown significant association between OA patients and HS. However, between OA patients and HS a significant differences were observed in BMI, age, apo A-I and apo B, independently of both polymorphisms studied (P<0.05). In conclusion, increased apo A-1 and apo B levels are associated in knee OA, but the -460 T/C and +405 C/G VEGF polymorphisms are not associated with knee OA susceptibility.
Sánchez-Enríquez
Sergio
S
Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Torres-Carrillo
Nora Magdalena
NM
Vázquez-Del Mercado
Mónica
M
Salgado-Goytia
Lorenzo
L
Rangel-Villalobos
Héctor
H
Muñoz-Valle
José Francisco
JF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016632:Apolipoprotein A-I / Q000097:blood / Q000235:genetics*; D001055:Apolipoproteins B / Q000097:blood / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000235:genetics*
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A