title: Demyelinating sensorimotor polyneuropathy associated with the use of sirolimus: a case report.
abstract: Liver transplantation is associated with a number of neurological complications. We herein report a case of chronic inflammatory demyelinating polyneuropathy associated with the use of sirolimus-based immunosuppression. The patient was treated by converting the immunosuppression from sirolimus to cyclosporine and by a short course of oral steroids. Following this, we observed almost complete clinical and electrophysiologic resolution of this syndrome. We believe that this is the first described case of such a complication occurring in association with sirolimus. This immunosuppressive agent can, therefore, lead to neurological complications similar to the ones that have been observed with calcineurin inhibitors.
authors.affiliation: Service d'hépatologie, Hôpital Saint-Luc du CHUM, Montréal, Québec, Canada. Marc.Bilodeau@umontreal.ca
authors.forename: M
authors.initials: M
authors.lastname: Bilodeau
authors.forename: Z
authors.initials: Z
authors.lastname: Hassoun
authors.forename: D
authors.initials: D
authors.lastname: Brunet
mesh_terms: D016572:Cyclosporine / Q000627:therapeutic use*; D003711:Demyelinating Diseases / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016031:Liver Transplantation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000139:chemically induced*; D020123:Sirolimus / Q000009:adverse effects*; D019896:alpha 1-Antitrypsin Deficiency / Q000601:surgery*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D020123:Sirolimus