The current clinical management of Huntington's disease.
Huntington's disease is a neurodegenerative condition, characterized by movement disorders, cognitive decline, and psychiatric disturbance. We review the pharmacological management of the various movement disorders associated with the disease, the cognitive decline and the commonly encountered behavioral disturbances. We discuss the nonclassical features of the disease, important in the management of these patients. Nonpharmacological support including genetic counseling and therapy and the importance of palliative care are also addressed. Finally, experimental approaches that may soon impact upon clinical practice are discussed.
Phillips
Wendy
W
Cambridge Centre for Brain Repair, E.D. Adrian Building, Forvie Site, Cambridge, United Kingdom.
Shannon
Kathleen M
KM
Barker
Roger A
RA
D003072:Cognition Disorders / Q000188:drug therapy / Q000209:etiology; D003937:Diagnosis, Differential; D005817:Genetic Counseling; D006801:Humans; D006816:Huntington Disease / Q000150:complications / Q000628:therapy*; D001523:Mental Disorders / Q000188:drug therapy / Q000209:etiology; D009069:Movement Disorders / Q000188:drug therapy / Q000209:etiology; D010166:Palliative Care