title: Automated measurement of joint space width in small joints of patients with rheumatoid arthritis.
abstract: OBJECTIVE
  Comparison of performances of 5 (semi)automated methods in measuring joint space width (JSW) in rheumatoid arthritis.
  
  
  METHODS
  Change in JSW was determined by 5 measurement methods on 4 radiographs per patient from 107 patients included in the COBRA trial (comparing sulfasalazine alone or in combination with methotrexate and corticosteroids). For each method the number of patients with sufficient available results was assessed (efficiency). An independent repeated measurement was carried out on a random sample of 30 patients' baseline and 1-year radiographs, to evaluate within-method reliability of change scores. Discriminatory ability (DA) of the measurement methods (between the 2 treatment arms) was compared with the DA of the Sharp-van der Heijde score (SHS) and its 2 components (erosion and JSW scores).
  
  
  RESULTS
  The overall success rate varied widely between methods. Applying the chosen threshold of a minimum of 50% available joints with a change score per patient resulted in a success rate > 92% in 4/5 methods. Repeatability of measurements was good for most methods (intraclass correlation coefficient > or = 0.80 in 4/5 methods). Almost all measurement methods in 3 followup periods (12/14) showed a lower mean loss of JSW in patients from the intensive treatment group, although this was rarely statistically significant, confirming the known difference in structural damage. JSW as measured by the (semi)automated systems often showed higher DA than the JSW score of the SHS, but was lower than the total SHS and erosion scores.
  
  
  CONCLUSIONS
  Although efficiency of the methods should be improved further, results already show good reliability and encouraging DA of most methods. Optimal information may be obtained with a combination of scoring of erosions and (semi)automated measurement of JSW.
authors.affiliation: University of Maastricht, Maastricht, The Netherlands.
authors.forename: Cédric
authors.initials: C
authors.lastname: Lukas
authors.forename: John T
authors.initials: JT
authors.lastname: Sharp
authors.forename: Jane
authors.initials: J
authors.lastname: Angwin
authors.forename: Maarten
authors.initials: M
authors.lastname: Boers
authors.forename: Jeff
authors.initials: J
authors.lastname: Duryea
authors.forename: James R
authors.initials: JR
authors.lastname: Hall
authors.forename: Joost A
authors.initials: JA
authors.lastname: Kauffman
authors.forename: Robert
authors.initials: R
authors.lastname: Landewé
authors.forename: Georg
authors.initials: G
authors.lastname: Langs
authors.forename: Hein J
authors.initials: HJ
authors.lastname: Bernelot Moens
authors.forename: Philipp
authors.initials: P
authors.lastname: Peloschek
authors.forename: Désirée
authors.initials: D
authors.lastname: van der Heijde
mesh_terms: D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000473:pathology; D001175:Arthrography; D033023:Foot Joints / Q000000981:diagnostic imaging* / Q000473:pathology; D050823:Hand Joints / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D016032:Randomized Controlled Trials as Topic