title: Asymmetric deprotonation-substitution of N-Pop-benzylamines using [RLi/(-)-sparteine]. Enantioselective sequential reactions and synthesis of N-heterocycles.
abstract: Pop-directed asymmetric deprotonation of benzylic amines using [n-BuLi/(-)-sparteine] provides an efficient method for the synthesis of chiral NC alpha and NC alpha,alpha' derivatives with total selectivity with respect to competing allylic and ortho lithiation. The method described herein offers a straightforward route of accessing chiral N-Pop-protected nitrogen heterocycles.
authors.affiliation: Area de Química Orgánica, Universidad de Almería, Carretera de Sacramento s/n, 04120 Almería, Spain.
authors.forename: Pascual
authors.initials: P
authors.lastname: Oña-Burgos
authors.forename: Ignacio
authors.initials: I
authors.lastname: Fernández
authors.forename: Laura
authors.initials: L
authors.lastname: Roces
authors.forename: Laura
authors.initials: L
authors.lastname: Torre-Fernández
authors.forename: Santiago
authors.initials: S
authors.lastname: García-Granda
authors.forename: Fernando
authors.initials: F
authors.lastname: López-Ortiz