title: Relation of heart rate with cardiovascular disease in normal-weight individuals: the Chicago Heart Association Detection Project in Industry.
abstract: The authors investigated the association of resting heart rate (RHR) with cardiovascular disease (CVD) risk factors and mortality among normal-weight individuals. Using data from our cohort (baseline examination in 1967-1973), individuals with a body mass index of 18.5 to 24.9 kg/m(2) (men [n=3724] and women [n=4929] aged 18-39; men [n=1959] and women [n=3735] aged 40-59), were grouped by RHR: <75, 75-84, and > or =85 beats per minute (bpm). A lower RHR was associated with lower mean blood pressure (BP) and cigarette use in each subgroup and total cholesterol (TC) and diabetes in men (P<.05). After a 32-year follow-up, hazard ratios (95% confidence intervals) for CVD mortality for an RHR <75 compared with > or =85 bpm adjusted for age, race, education level, BP, cigarette use, diabetes, and TC were 0.58 (0.34-0.84), 0.73(0.56-0.95), and 0.77 (0.61-0.98) for men aged 18 to 39 and men and women aged 40 to 59, respectively. In women aged 18 to 39, the relationship was not significant. In general, normal-weight individuals with lower RHRs have lower levels of CVD risk factors and mortality.
authors.affiliation: Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 Lake Shore Drive, Chicago, IL 60611, USA.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Kizilbash
authors.forename: Martha L
authors.initials: ML
authors.lastname: Daviglus
authors.forename: Alan R
authors.initials: AR
authors.lastname: Dyer
authors.forename: Dan B
authors.initials: DB
authors.lastname: Garside
authors.forename: Arlene L
authors.initials: AL
authors.lastname: Hankinson
authors.forename: Lijing L
authors.initials: LL
authors.lastname: Yan
authors.forename: Lu
authors.initials: L
authors.lastname: Tian
authors.forename: Linda
authors.initials: L
authors.lastname: Van
authors.forename: Renwei
authors.initials: R
authors.lastname: Wang
authors.forename: Philip
authors.initials: P
authors.lastname: Greenland
mesh_terms: D000328:Adult; D001835:Body Weight / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology; D002641:Chicago / Q000453:epidemiology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012955:Societies, Medical; D015996:Survival Rate / Q000639:trends