Hyperleptinemia is associated with hypertension in Japanese males.
Leptin is a hormone which is predominantly secreted by adipose tissue. Recent studies have shown that leptin increases arterial blood pressure. Although data from available animal studies clearly indicate an association between leptin and hypertension, results of human studies have been less definitive. We conducted a case-control study to examine the association between serum leptin levels and hypertension in 111 hypertensive subjects and 222 male controls, using conditional logistic regression analyses. Mean serum leptin levels were found to be marginally higher in the case subjects than in the control subjects (3.3 ng/ml versus 3.0 ng/ml), however, conditional logistic regression analysis revealed that subjects in the highest quartile had a significantly increased risk of hypertension compared with those in the lowest quartile, even after adjusting for drinking status and diabetes mellitus (adjusted OR, 2.11;95% CI, 1.01-4.39). Our findings suggest that leptin plays an important role in the development of hypertension.
Imatoh
Takuya
T
Department Hygiene and Preventive Medicine, School of Medicine, Fukuoka University, Fukuoka 814-0180, Japan. imatoh@cis.fukuoka-u.ac.jp
Miyazaki
Motonobu
M
Momose
Yoshito
Y
Uryu
Yoko
Y
Tanihara
Shinichi
S
Une
Hiroshi
H
Doi
Hiroyuki
H
D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000208:ethnology / Q000503:physiopathology; D007564:Japan; D020738:Leptin / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests
D015415:Biomarkers; D020738:Leptin