title: Development of human striatal anlagen after transplantation in a patient with Huntington's disease.
abstract: Replacement of damaged neuronal population by fetal tissue transplantation represents a potential treatment for neurodegenerative diseases. Consistent success has been achieved with fetal striatal transplantation in Huntington's disease animal models and patients. We report the neo-generation of metabolically active tissue with striatum-like imaging features after transplantation of striatal primordia in a patient with Huntington's disease. This study represents the first "in vivo" demonstration that a human striatal anlagen, transplanted into the adult human brain, is able to progress in its development and to generate a new anatomical structure in the host, without evidence of neoplasia or teratoma.
authors.affiliation: Department of Neurosurgery, University of Florence, Florence, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Gallina
authors.forename: Marco
authors.initials: M
authors.lastname: Paganini
authors.forename: Letizia
authors.initials: L
authors.lastname: Lombardini
authors.forename: Riccardo
authors.initials: R
authors.lastname: Saccardi
authors.forename: Mirca
authors.initials: M
authors.lastname: Marini
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: De Cristofaro
authors.forename: Pamela
authors.initials: P
authors.lastname: Pinzani
authors.forename: Francesca
authors.initials: F
authors.lastname: Salvianti
authors.forename: Clara
authors.initials: C
authors.lastname: Crescioli
authors.forename: Andrea
authors.initials: A
authors.lastname: Di Rita
authors.forename: Sandra
authors.initials: S
authors.lastname: Bucciantini
authors.forename: Claudia
authors.initials: C
authors.lastname: Mechi
authors.forename: Erica
authors.initials: E
authors.lastname: Sarchielli
authors.forename: Marco
authors.initials: M
authors.lastname: Moretti
authors.forename: Silvia
authors.initials: S
authors.lastname: Piacentini
authors.forename: Gaetano
authors.initials: G
authors.lastname: Gritti
authors.forename: Alberto
authors.initials: A
authors.lastname: Bosi
authors.forename: Sandro
authors.initials: S
authors.lastname: Sorbi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Orlandini
authors.forename: Gabriella B
authors.initials: GB
authors.lastname: Vannelli
authors.forename: Nicola
authors.initials: N
authors.lastname: Di Lorenzo
mesh_terms: D000328:Adult; D016380:Brain Tissue Transplantation / Q000379:methods*; D002478:Cells, Cultured; D003342:Corpus Striatum / Q000196:embryology* / Q000378:metabolism / Q000637:transplantation*; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D016332:Fetal Tissue Transplantation / Q000379:methods*; D007839:Functional Laterality / Q000502:physiology; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D009473:Neuronal Plasticity / Q000502:physiology; D038361:Neuronavigation; D049268:Positron-Emission Tomography; D013238:Stereotaxic Techniques; D016896:Treatment Outcome