title: The cyclic AMP phenotype of fragile X and autism.
abstract: Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism.
authors.affiliation: Waisman Laboratory for Brain Imaging and Behavior, Waisman Center, University of Wisconsin, Madison, WI, USA. djkelley@wisc.edu
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Kelley
authors.forename: Anita
authors.initials: A
authors.lastname: Bhattacharyya
authors.forename: Garet P
authors.initials: GP
authors.lastname: Lahvis
authors.forename: Jerry C P
authors.initials: JC
authors.lastname: Yin
authors.forename: Jim
authors.initials: J
authors.lastname: Malter
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Davidson
mesh_terms: D000818:Animals; D001007:Anxiety / Q000378:metabolism; D001321:Autistic Disorder / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics; D005600:Fragile X Syndrome / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008568:Memory / Q000502:physiology; D008954:Models, Biological; D010641:Phenotype
chemical_list: D000242:Cyclic AMP; D051860:Fragile X Messenger Ribonucleoprotein 1