Biological basis for the surgical treatment of depression.
An estimated 20% of patients with major depression are refractory to existing therapies. The purpose of this review is to provide a theoretical and neuroscientific framework in which to interpret new work in the field of surgical treatment for depression. This review focuses on existing clinical and imaging data, current disease models, and results of recent case reports and patient series that together may inform the construction of appropriate clinical trials for the surgical treatment of refractory depression.
Abosch
Aviva
A
Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, Minnesota, USA. aabosch@umn.edu
Cosgrove
G Rees
GR
D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D002986:Clinical Trials as Topic / Q000592:standards; D046690:Deep Brain Stimulation / Q000592:standards / Q000639:trends; D003866:Depressive Disorder / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D003952:Diagnostic Imaging / Q000592:standards / Q000639:trends; D004195:Disease Models, Animal; D006801:Humans; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D019635:Neurosurgical Procedures / Q000592:standards* / Q000639:trends*; D010348:Patient Care Team / Q000592:standards / Q000639:trends; D011612:Psychosurgery / Q000592:standards* / Q000639:trends*