title: Augmented muscle vasodilatory responses in obese children with Glu27 beta-2-adrenoceptor polymorphism.
abstract: This study examined forearm vasodilatation during mental challenge and exercise in 72 obese children (OC; age = 10 +/- 0.1 years) homozygous with polymorphism in the allele 27 of the beta-2-adrenoceptors: Gln27 (n = 61) and Glu27 (n = 11). Forearm blood flow was recorded during 3 min of each using the Stroop color-word test (MS) and handgrip isometric exercise. Baseline hemodynamic and vascular measurements were similar. During the MS, peak forearm vascular conductance was significantly greater in group Glu27 (Delta = 0.35 +/- 0.4 vs. 0.12 +/- 0.1 units, respectively, p = .042). Similar results were found during exercise (Delta = 0.64 +/- 0.1 vs. 0.13 +/- 0.1 units, respectively, p = .035). Glu27 OC increased muscle vasodilatory responsiveness upon the MS and exercise.
authors.affiliation: Dept. of Endocrinology, University of Sao Paulo, Brazil.
authors.forename: Alexandre G
authors.initials: AG
authors.lastname: da Silva
authors.forename: Mauricio M
authors.initials: MM
authors.lastname: Ribeiro
authors.forename: Ivani C
authors.initials: IC
authors.lastname: Trombetta
authors.forename: Christiane
authors.initials: C
authors.lastname: Nicolau
authors.forename: Eliana
authors.initials: E
authors.lastname: Frazzatto
authors.forename: Isabel
authors.initials: I
authors.lastname: Guazzelli
authors.forename: Luciana N J
authors.initials: LN
authors.lastname: Matos
authors.forename: Alfredo
authors.initials: A
authors.lastname: Halbern
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Negrão
authors.forename: Sandra M F
authors.initials: SM
authors.lastname: Villares
mesh_terms: D000886:Anthropometry; D015992:Body Mass Index; D002648:Child; D002669:Child Welfare; D003071:Cognition; D015444:Exercise; D005080:Exercise Test; D005260:Female; D005542:Forearm / Q000098:blood supply; D018737:Hand Strength; D006439:Hemodynamics; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology; D011110:Polymorphism, Genetic; D011594:Psychometrics; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics* / Q000378:metabolism; D013315:Stress, Psychological; D014664:Vasodilation
chemical_list: D018343:Receptors, Adrenergic, beta-2