title: [Lipoatrophy after use of long acting insulin glargine analogue in a 32-year-old patient with type 1 diabetes].
abstract: A case of a 32-year-old woman with type 1 diabetes diagnosed 1.5 year before presention. The patient was referred to the diabetology department due to decompensation of diabetes and excessive hypodermic atrophy of both thighs. Early symptoms of lipoatrophy appeared after 1.5-2 months of insulin glargine use, in spite of frequently changed hypodermic needles and injection sites on both thighs. Simultaneously, deterioration of diabetes compensation was observed (hyperglycaemia between meals and in the morning), which was corrected by the patient with extra injections of a short acting analogue. Additional examinations confirmed type 1 diabetes (C-peptide <0.01 ng/ml) with concomitant hypothyroidism in the course oh Hashimoto disease. After change of insulin (Insulatard twice daily, Novo Rapid with meals) and injection site (administration to hypodermic tissues of arms and abdomen was started), diabetes compensation was achieved. At follow-up visit after 12 months, diabetes was still under control - HbA1c 6.8%. Moreover, progress of lipoatrophy is not observed.
authors.affiliation: Oddział Diabetologiczny Miedziowego Centrum Zdrowia w Lubinie. mariadziura@wp.pl
authors.forename: Maria
authors.initials: M
authors.lastname: Dziura
authors.forename: Renata
authors.initials: R
authors.lastname: Wasikowa
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D050031:Hashimoto Disease / Q000150:complications; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D007037:Hypothyroidism / Q000150:complications; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D061267:Insulin Aspart; D000069036:Insulin Glargine; D007336:Insulin, Isophane; D049528:Insulin, Long-Acting / Q000008:administration & dosage; D061386:Insulin, Regular, Human; D000068880:Isophane Insulin, Human; D008060:Lipodystrophy / Q000139:chemically induced* / Q000517:prevention & control*; D008297:Male
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D049528:Insulin, Long-Acting; D061386:Insulin, Regular, Human; D000068880:Isophane Insulin, Human; D000069036:Insulin Glargine; D007336:Insulin, Isophane; D061267:Insulin Aspart