Pediatric human immunodeficiency virus infection and circulating IgD+ memory B cells.
Levels of circulating naive and memory B cells were measured in human immunodeficiency virus (HIV)-infected children and control subjects to determine whether the irreversible depletion of memory B cells described in HIV-infected adults occurs in children with HIV infection. Depletion of circulating IgD+ memory B cells was seen in HIV-infected children despite control of the HIV load with highly active antiretroviral therapy (HAART) (P =. 04). IgD+ memory B cell percentages did not correlate with CD4+ cell percentages (P =. 027) or disease duration (P =. 026). Naive/transitional and IgD- memory B cell numbers were not affected. Pediatric HIV infection is associated with selective depletion of circulating IgD+ memory B cells despite control of the HIV load with HAART.
Jacobsen
Marianne C
MC
Infectious Diseases and Microbiology Unit, Hugh and Catherine Stevenson Centre for Childhood Infectious Diseases and Immunology, Institute of Child Health, University College London, United Kingdom.
Thiébaut
Rodolphe
R
Fisher
Christopher
C
Sefe
Delali
D
Clapson
Margaret
M
Klein
Nigel
N
Baxendale
Helen E
HE
D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active; D001402:B-Lymphocytes; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D007072:Immunoglobulin D / Q000097:blood*; D007156:Immunologic Memory; D008297:Male; D010372:Pediatrics; D019562:Viral Load / Q000706:statistics & numerical data
D007072:Immunoglobulin D