title: Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein.
abstract: The kinetics of peptide presentation by major histocompatibility complex class I (MHC-I) molecules may contribute to the efficacy of CD8+ T cells. Whether all CD8+ T-cell epitopes from a protein are presented by the same MHC-I molecule with similar kinetics is unknown. Here we show that CD8+ T-cell epitopes derived from SIVmac239 Gag are presented with markedly different kinetics. We demonstrate that this discrepancy in presentation is not related to immunodominance but instead is due to differential requirements for epitope generation. These results illustrate that significant differences in presentation kinetics can exist among CD8+ T-cell epitopes derived from the same viral protein.
authors.affiliation: Wisconsin National Primate Research Center (WNPRC), Madison, WI 53711, USA.
authors.forename: Jonah B
authors.initials: JB
authors.lastname: Sacha
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Reynolds
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Buechler
authors.forename: Chungwon
authors.initials: C
authors.lastname: Chung
authors.forename: Anna K
authors.initials: AK
authors.lastname: Jonas
authors.forename: Lyle T
authors.initials: LT
authors.lastname: Wallace
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Weiler
authors.forename: Wonhee
authors.initials: W
authors.lastname: Lee
authors.forename: Shari M
authors.initials: SM
authors.lastname: Piaskowski
authors.forename: Taeko
authors.initials: T
authors.lastname: Soma
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Friedrich
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Wilson
authors.forename: David I
authors.initials: DI
authors.lastname: Watkins
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000502:physiology*; D000938:Antigen-Presenting Cells; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D015683:Gene Products, gag / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism*; D016056:Immunodominant Epitopes; D007700:Kinetics; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000378:metabolism*
chemical_list: D018984:Epitopes, T-Lymphocyte; D015683:Gene Products, gag; D015395:Histocompatibility Antigens Class I; D016056:Immunodominant Epitopes