title: P-TSA catalyzed facile and efficient synthesis of polyhydroquinoline derivatives through hantzsch multi-component condensation.
abstract: A facile and efficient synthetic route to polyhydroquinolines has been developed via four-component condensation reactions of aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of p-toluenesulfonic acid (p-TSA) catalyst in ethanol at ambient temperature through Hantzsch reaction. Simple work-up procedure, environmentally friendly, inexpensive and non-toxic catalyst, shorter reaction times along with excellent product yields are the significant features of this practical method.
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal, India. chsrkuc@yahoo.co.in
authors.forename: Sanjeeva Reddy
authors.initials: SR
authors.lastname: Cherkupally
authors.forename: Raghu
authors.initials: R
authors.lastname: Mekala
mesh_terms: D001557:Benzenesulfonates / Q000737:chemistry*; D002384:Catalysis; D011108:Polymers / Q000138:chemical synthesis; D011804:Quinolines / Q000138:chemical synthesis*
chemical_list: D001557:Benzenesulfonates; D011108:Polymers; D011804:Quinolines; C029501:4-toluenesulfonic acid