title: Drug induced hepatitis with anti-tubercular chemotherapy: challenges and difficulties in treatment.
abstract: Tuberculosis is a major health burden worldwide. In Nepal, it is a significant cause of morbidity and mortality. Although better drugs are available for managing tuberculosis, treatment failure is one of the common problems encountered. Among the various causes which can cause treatment interruption, drug induced hepatotoxicity is a common cause. Isoniazid and Pyrazinamide are the common drugs causing hepatotoxicity. Upon occurrence of hepatotoxicity, the hepatotoxic drugs should be stopped and reintroduced as per the available guidelines. The healthcare professional should also counsel the patients for recognizing the early symptoms due to hepatotoxicity which could prevent morbidity.
authors.affiliation: Department of Medicine, Manipal College of Medical Sciences, Pokhara, Nepal. pandu_vki@yahoo.com
authors.forename: P V
authors.initials: PV
authors.lastname: Kishore
authors.forename: S
authors.initials: S
authors.lastname: Palaian
authors.forename: R
authors.initials: R
authors.lastname: Paudel
authors.forename: P
authors.initials: P
authors.lastname: Mishra
authors.forename: M
authors.initials: M
authors.lastname: Prabhu
authors.forename: P R
authors.initials: PR
authors.lastname: Shankar
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects*; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000209:etiology*; D006801:Humans
chemical_list: D000995:Antitubercular Agents