Recurrent peanut allergy may not be prevented by continued peanut ingestion.
Recurrent peanut allergy has been described in patients who have previously passed an oral food challenge [N Engl J Med 2002;347:1535-1536]. It has been suggested that recurrent peanut allergy might be prevented by regular ingestion of peanut subsequent to passing an oral food challenge [J Allergy Clin Immunol 2004;114:1195-1201]. We present a case that challenges this thinking by demonstrating that peanut allergy may recur during regular ingestion of significant doses of peanut protein. The case suggests that current practice cannot guarantee freedom from recurrent peanut allergy, and it is important that patients and their families are aware of this.
Boyle
Robert J
RJ
Allergy and Immune Disorders, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Vic., Australia.
Tang
Mimi L-K
ML
D010367:Arachis / Q000009:adverse effects / Q000276:immunology*; D002675:Child, Preschool; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D021183:Peanut Hypersensitivity / Q000209:etiology / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D010940:Plant Proteins / Q000008:administration & dosage*; D012008:Recurrence
D010940:Plant Proteins