title: Dependence of antibody-mediated presentation of antigen on FcRn.
abstract: The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Shuo-Wang
authors.initials: SW
authors.lastname: Qiao
authors.forename: Kanna
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Finn-Eirik
authors.initials: FE
authors.lastname: Johansen
authors.forename: Ludvig M
authors.initials: LM
authors.lastname: Sollid
authors.forename: Jan Terje
authors.initials: JT
authors.lastname: Andersen
authors.forename: Edgar
authors.initials: E
authors.lastname: Milford
authors.forename: Derry C
authors.initials: DC
authors.lastname: Roopenian
authors.forename: Wayne I
authors.initials: WI
authors.lastname: Lencer
authors.forename: Richard S
authors.initials: RS
authors.lastname: Blumberg
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000276:immunology; D000938:Antigen-Presenting Cells / Q000166:cytology / Q000276:immunology; D049109:Cell Proliferation; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology; D006413:Hematopoietic System / Q000166:cytology / Q000276:immunology; D006433:Hemocyanins / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008024:Ligands; D051907:Lysosomal Membrane Proteins / Q000276:immunology; D008247:Lysosomes / Q000276:immunology; D051379:Mice; D009000:Monocytes / Q000166:cytology / Q000276:immunology; D009154:Mutation / Q000235:genetics; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D011961:Receptors, Fc / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D052118:Lysosomal-Associated Membrane Protein 1
chemical_list: D000936:Antigen-Antibody Complex; D006433:Hemocyanins; D015395:Histocompatibility Antigens Class I; D007074:Immunoglobulin G; D008024:Ligands; D051907:Lysosomal Membrane Proteins; D011961:Receptors, Fc; C052255:Lamp1 protein, mouse; D052118:Lysosomal-Associated Membrane Protein 1; C032808:keyhole-limpet hemocyanin; C100688:Fc receptor, neonatal