title: Rapid progression of prostate cancer in men with a BRCA2 mutation.
abstract: Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that BRCA2 carriers with prostate cancer have poorer survival than noncarrier prostate cancer patients. In this study, we compared survival of men with a BRCA2 mutation and prostate cancer with that of men with a BRCA1 mutation and prostate cancer. We obtained the age at diagnosis, age at death or current age from 182 men with prostate cancer from families with a BRCA2 mutation and from 119 men with prostate cancer from families with a BRCA1 mutation. The median survival from diagnosis was 4.0 years for men with a BRCA2 mutation vs 8.0 years for men with a BRCA1 mutation, and the difference was highly significant (P<0.01). It may be important to develop targeted chemotherapies to treat prostate cancer in men with a BRCA2 mutation.
authors.affiliation: Women's College Research Institute, 790 Bay Street, 7th Floor, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada. steven.narod@wchospital.ca
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authors.lastname: Narod
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authors.lastname: Sun
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authors.lastname: Danquah
authors.forename: Susan
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authors.lastname: Domchek
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authors.lastname: Ainsworth
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authors.forename: Marie
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authors.forename: Claudine
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authors.forename: Dawna
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authors.lastname: Gilchrist
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authors.lastname: Karlan
authors.forename: Raluca
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authors.lastname: Nedelcu
authors.forename: Wendy
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authors.lastname: Meschino
authors.forename: Judy
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authors.lastname: Garber
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mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology