title: Temporal statistical analysis of laser speckle images and its application to retinal blood-flow imaging.
abstract: Temporal-statistical analysis of laser-speckle image (TS-LSI) preserves the original spatial resolution, in contrast to conventional spatial-statistical analysis (SS-LSI). Concerns have been raised regarding the temporal independency of TS-LSI signals and its insensitivity toward stationary-speckle contamination. Our results from flow phantoms and in vivo rat retinas demonstrated that the TS-LSI signals are temporally statistically independent and TS-LSI minimizes stationary-speckle contamination. The latter is because the stationary speckle is "non-random" and thus non-ergodic where the temporal average of stationary speckle needs not equal its spatial ensemble average. TS-LSI detects blood flow in smaller blood vessels and is less susceptible to stationary-speckle artifacts.
authors.affiliation: Yerkes Imaging Center and Department of Neurology, Emory University, Atlanta, Georgia, 30329, USA. hcheng4@emory.edu
authors.forename: Haiying
authors.initials: H
authors.lastname: Cheng
authors.forename: Yumei
authors.initials: Y
authors.lastname: Yan
authors.forename: Timothy Q
authors.initials: TQ
authors.lastname: Duong
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D003952:Diagnostic Imaging / Q000295:instrumentation* / Q000379:methods; D003941:Diagnostic Techniques, Ophthalmological; D004867:Equipment Design; D007834:Lasers; D051381:Rats; D012160:Retina / Q000473:pathology*; D012171:Retinal Vessels / Q000473:pathology*; D013997:Time Factors