[Latent HBV infection in single blood donors].
A total of 14,366 one-time blood donors were examined; 984 (6.8%) donors of them were found to have anti-HBc. All anti-HBc-positive samples were tested for HBsAg, IgM anti-HBc, HBeAg, anti-HBe, and specific DNA-HBV by polymerase chain reaction (sensitivity 400 coplml or higher). Anti-HBc in combinations with HBsAg, anti-HBe, IgM anti-HBc was detected in 29 (2.9%), 3 (0.3%), 5 (0.5%) donors, respectively. Specific HBV DNA was identified in 29 donors with HBs-antigenemia and in 9 anti-HBc positive donors in the absence of serum HBsAg. The activity of AIAt was correlated with neither HBsAg nor HBV DNA. Thus, latent HBV infection is 0.9% of anti-HBc-positive one-time blood donors and tests for anti-HBc may be useful in identifying persons who need a more meticulous study for HBV DNA.
Fedorchenko
S V
SV
Zanevskaia
L I
LI
Burma
N M
NM
Borisevich
O S
OS
Balitskaia
T E
TE
Iurchenko
L F
LF
Martynovich
T L
TL
D000410:Alanine Transaminase / Q000097:blood; D001782:Blood Donors; D002353:Carrier State / Q000097:blood / Q000175:diagnosis*; D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D006509:Hepatitis B / Q000097:blood / Q000175:diagnosis* / Q000517:prevention & control; D006510:Hepatitis B Antibodies / Q000097:blood; D006512:Hepatitis B Core Antigens / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D016133:Polymerase Chain Reaction; D011933:Reagent Kits, Diagnostic; D014455:Ukraine / Q000453:epidemiology; D014505:Urban Population; D017735:Virus Latency
D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D011933:Reagent Kits, Diagnostic; D000410:Alanine Transaminase