The 6-hydroxydopamine model: news from the past.
The investigation of pathogenic and pathophysiological mechanisms of Parkinson's disease relies on experimental models reproducing, in the animal, the pathological and behavioural features of the disease. Despite the availability of innovative models, 6-hydroxydopamine (6-OHDA) remains the most widely used tool to induce a nigrostriatal lesion in the animal (rat). This is due to (1) the relatively low complexity and cost of the procedure, (2) the fact that the 6-OHDA-induced lesion is highly reproducible, and (3) the versatility of the procedure, which can yield varying degrees of nigrostriatal lesions that develop with different temporal profiles, depending on the site chosen for the toxin injection.
Blandini
Fabio
F
Interdepartmental Research Center for Parkinson's Disease (CRIMP), IRCCS Neurological Institute C. Mondino, Via Mondino 2, Pavia, Italy. fabio.blandini@mondino.it
Armentero
Marie-Therese
MT
Martignoni
Emilia
E
D018663:Adrenergic Agents / Q000633:toxicity*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D016627:Oxidopamine / Q000633:toxicity*; D010300:Parkinson Disease / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology
D018663:Adrenergic Agents; D016627:Oxidopamine