The B-cell response to protein antigens in immunity and transplantation.
The potential for B cells to play a role in transplantation has been recently increasingly recognized. Given that the field has focused almost exclusively on the T cell, here we review B-cell biology. We first describe the B-cell response to protein antigen, and then examine the antibody-independent effector functions of B cells, in particular antigen presentation to T cells. Finally we use autoimmunity as an analogy to focus on the potential role for B cells in transplantation. The direct evidence for this is then marshalled in the accompanying article by Zarkhin and Sarwal.
Tarlinton
David M
DM
Batista
Facundo
F
Smith
Kenneth G C
KG
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology