Blends of TiO2 nanoparticles and poly (N-isopropylacrylamide)-co-polystyrene nanofibers as a means to promote the biorecognition of an anticancer drug.
The poly (N-isopropylacrylamide)-co-polystyrene (PNIPAM-co-PS) nanofibers have been fabricated by electrospinning, and the blends of PNIPAM-co-PS nanofibers with titanium dioxide (TiO(2)) nanoparticles have been characterized and utilized as the new nanocomposites to enhance the relevant detection sensitivity of biomolecular recognition of an anticancer drug daunorubicin. Our observations demonstrate that upon application of the nanoTiO(2)-PNIPAM-co-PS polymer nanocomposites, the drug molecules could be readily deposited on the surface of the relevant blends so that the remarkable enhancement effect of the new nanocomposites on the respective biorecognition of daunorubicin could be observed, suggesting the potential valuable application of the blending of the nanoTiO(2) and PNIPAM-co-PS polymer nanocomposites in high sensitive bioanalysis.
Song
Min
M
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, China.
Pan
Chao
C
Li
Jingyuan
J
Zhang
Renyun
R
Wang
Xuemei
X
Gu
Zhongze
Z
D000180:Acrylic Resins / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000737:chemistry; D003630:Daunorubicin / Q000737:chemistry; D004563:Electrochemistry; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry*; D012680:Sensitivity and Specificity; D014025:Titanium / Q000737:chemistry*
D000180:Acrylic Resins; D000970:Antineoplastic Agents; D011137:Polystyrenes; C532499:poly(N-isopropylacrylamide)-co-polystyrene; C009495:titanium dioxide; D004247:DNA; D014025:Titanium; D003630:Daunorubicin