title: Serum urate, metabolic syndrome, and cardiovascular risk factors. A population-based study.
abstract: We studied the associations between serum urate levels (determined in 503 subjects from a population of 1,344 subjects living in northern Madrid) and both the metabolic syndrome (MS) (defined by the Adult Treatment Panel III criteria) and C-reactive protein (CRP, determined in 382 subjects). MS was diagnosed in 25% (95%CI, 21-28%) and was associated with hyperuricemia (p<0.001). There was a graded increase in serum urate levels with increasing number of MS components. Urate concentrations significantly correlated with waist circumference (r=0,455, p<0.01). Serum urate was not independently associated with CRP levels. This study shows that serum urate levels are associated with the presence of MS and each of its features.
authors.affiliation: Divisions of Internal Medicine, La Paz University Hospital, Madrid, Spain. jgpuig@terra.es
authors.forename: J G
authors.initials: JG
authors.lastname: Puig
authors.forename: M A
authors.initials: MA
authors.lastname: Martínez
authors.forename: M
authors.initials: M
authors.lastname: Mora
authors.forename: J M
authors.initials: JM
authors.lastname: Fraile
authors.forename: F
authors.initials: F
authors.lastname: Montoya
authors.forename: R J
authors.initials: RJ
authors.lastname: Torres
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology* / Q000378:metabolism; D008875:Middle Aged; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D002097:C-Reactive Protein