title: [Lung cancer diagnosis based on urinary modified nucleoside metabolic profiling].
abstract: OBJECTIVE
  To study the feasibility of modified urinary nucleosides metabolic profiling on lung cancer diagnoses.
  
  
  METHODS
  The modified urinary nucleosides metabolic profiling from 42 normal adults and 80 patients with lung cancer were determined by a coupled-column high performance liquid chromatography system. Partial least squares-discriminant analysis (PLS-DA) models were used to class differentiation between the lung cancer patients and controls and to discover potential biomarkers.
  
  
  RESULTS
  The PLS-DA model results showed that there was a clear differentiation between normal adults and lung cancers patients, with the value of prediction (Q2) equals to 0.744.
  
  
  CONCLUSIONS
  Modified urinary nucleosides metabolic profiling method is useful for lung cancer diagnoses.
authors.affiliation: Metabonomics Research Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Wen-Zhao
authors.initials: WZ
authors.lastname: Wang
authors.forename: Xin-Jie
authors.initials: XJ
authors.lastname: Zhao
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Fang-Lou
authors.initials: FL
authors.lastname: Li
authors.forename: Guo-Wang
authors.initials: GW
authors.lastname: Xu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine; D006801:Humans; D016018:Least-Squares Analysis; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000652:urine; D055442:Metabolome; D008954:Models, Biological; D009705:Nucleosides / Q000652:urine*
chemical_list: D015415:Biomarkers; D009705:Nucleosides