Experimental optic neuritis induced by a demyelinating strain of mouse hepatitis virus.
Optic neuritis (ON), an inflammatory demyelinating optic nerve disease, occurs in multiple sclerosis (MS). Pathological mechanisms and potential treatments for ON have been studied via experimental autoimmune MS models. However, evidence suggests that virus-induced inflammation is a likely etiology triggering MS and ON; experimental virus-induced ON models are therefore required. We demonstrate that MHV-A59, a mouse hepatitis virus (MHV) strain that causes brain and spinal cord inflammation and demyelination, induces ON by promoting mixed inflammatory cell infiltration. In contrast, MHV-2, a nondemyelinating MHV strain, does not induce ON. Results reveal a reproducible virus-induced ON model important for the evaluation of novel therapies.
Shindler
Kenneth S
KS
FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia,Pennsylvania 19104, USA.
Kenyon
Lawrence C
LC
Dutt
Mahasweta
M
Hingley
Susan T
ST
Das Sarma
Jayasri
J
D000818:Animals; D001921:Brain / Q000473:pathology; D039481:CD11b Antigen / Q000378:metabolism; D003711:Demyelinating Diseases / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D019084:Fluorescent Antibody Technique, Indirect; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D006517:Murine hepatitis virus / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity; D009902:Optic Neuritis / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D013116:Spinal Cord / Q000473:pathology
D039481:CD11b Antigen