title: Recurrent melanotic neuroectodermal tumor of infancy: a proposal for treatment protocol with surgery and adjuvant chemotherapy.
abstract: The case of a 4-month-old male infant treated with combined surgery and chemotherapy for an aggressive recurrent melanotic neuroectodermal tumor of infancy (MNTI) on the top of the alveolar process of the mandible with a long-term follow-up is presented. Initial treatment comprised conservative local excision and curettage of the mandible. After several local recurrences and because radical surgical excision would give gross functional and aesthetic mutilation, finally complete, long-lasting remission was achieved with adjuvant chemotherapy, according to a neuroblastoma protocol (10-year follow-up). The reason for this protocol was because molecular genetic studies of this tumor showed loss of heterozygosity of chromosome 1p and gain of chromosome 7q analogue to neuroblastomas. A combination of surgery and chemotherapy should be the preferred treatment in case of a recurrence MNTI because optimal functional and aesthetic outcome.
authors.affiliation: Oral and Maxillofacial Surgeon, Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Johannus
authors.initials: J
authors.lastname: Neven
authors.forename: Christine
authors.initials: C
authors.lastname: Hulsbergen-van der Kaa
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Groot-Loonen
authors.forename: Peter C M
authors.initials: PC
authors.lastname: de Wilde
authors.forename: Matthais A W
authors.initials: MA
authors.lastname: Merkx
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D055028:Comparative Genomic Hybridization; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007223:Infant; D019656:Loss of Heterozygosity; D008297:Male; D008339:Mandibular Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000601:surgery*; D009364:Neoplasm Recurrence, Local; D017600:Neuroectodermal Tumor, Melanotic / Q000188:drug therapy* / Q000235:genetics / Q000601:surgery*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D005047:Etoposide; D016190:Carboplatin; D007069:Ifosfamide