title: Diagnostic value of rapid urease test and urea breath test for Helicobacter pylori detection in patients with Billroth II gastrectomy: a prospective controlled trial.
abstract: OBJECTIVE
  The aim of this work was to assess the reliability of rapid urease test (RUT) and urea breath test (UBT) for detecting Helicobacter pylori (H. pylori) in patients with Billroth II (BII) gastrectomy, using histology as reference.
  
  
  METHODS
  In this prospective controlled study, 31 consecutive patients with BII gastrectomy and 73 controls who had an indication for endoscopy were included. Their H. pylori status was assessed with biopsies for histology, RUT and UBT. Histology served as the gold standard. Only the biopsies from the gastric fundus were evaluated. Specificity, sensitivity, positive and negative predictive value, degree of agreement and k-statistics were used.
  
  
  RESULTS
  RUT and UBT for detecting H. pylori in the control group had excellent agreement [97%, kappa (k)=0.94 and 99%, k=0.97 respectively] with biopsies. In BII patients, RUT from fundic biopsies had very good agreement (87%, k=0.74) compared to histology from fundic biopsies, whereas the UBT was unreliable (agreement: 71%, k=0.41) compared to histology.
  
  
  CONCLUSIONS
  The RUT from fundic biopsies in BII patients is a reliable test for H. pylori detection, whereas the UBT is unreliable.
authors.affiliation: 3rd Department of Internal Medicine, University of Athens Medical School, Sotiria Hospital, Athens, Greece. adamadam@hol.gr
authors.forename: A B
authors.initials: AB
authors.lastname: Adamopoulos
authors.forename: G S
authors.initials: GS
authors.lastname: Stergiou
authors.forename: G N
authors.initials: GN
authors.lastname: Sakizlis
authors.forename: D G
authors.initials: DG
authors.lastname: Tiniakos
authors.forename: E G
authors.initials: EG
authors.lastname: Nasothimiou
authors.forename: D K
authors.initials: DK
authors.lastname: Sioutis
authors.forename: A D
authors.initials: AD
authors.lastname: Achimastos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001944:Breath Tests / Q000379:methods*; D016145:Endoscopy, Digestive System; D005260:Female; D005743:Gastrectomy; D005763:Gastroenterostomy; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000382:microbiology* / Q000601:surgery; D016480:Helicobacter pylori / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D013270:Stomach / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D014508:Urea / Q000032:analysis
chemical_list: D014508:Urea