title: Three-dimensional alveolar bone reconstruction with a combination of recombinant human platelet-derived growth factor BB and guided bone regeneration: a case report.
abstract: A report of a patient who presented with severe disfigurement of the maxillary left lateral incisor and canine area following oncologic surgery is presented. The bone defect extended 20 mm from the cervical line of adjacent teeth up to and including the nasal cavity. Treatment was performed with a 1:1 ratio of autogenous bone graft (harvested from the retromolar region) and deproteinized bovine bone particles. The composite graft was hydrolyzed with recombinant human platelet-derived growth factor BB and covered with a titanium-reinforced nonresorbable membrane. Second-stage surgery was performed at 6 months, at which point the membrane was removed and two titanium dental implants were successfully placed. The elapsed time from initial surgery to definitive prosthesis placement was 14 months.
authors.affiliation: Department of Periodontology, School of Dentistry, University of Milan, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Simion
authors.forename: Isabella
authors.initials: I
authors.lastname: Rocchietta
authors.forename: Maurizio
authors.initials: M
authors.lastname: Monforte
authors.forename: Emilio
authors.initials: E
authors.lastname: Maschera
mesh_terms: D000328:Adult; D000543:Alveoloplasty / Q000379:methods*; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000077214:Becaplermin; D001857:Bone Matrix / Q000637:transplantation; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation / Q000379:methods; D015921:Dental Implants; D019094:Dental Prosthesis, Implant-Supported; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008437:Maxilla / Q000601:surgery; D008439:Maxillary Diseases / Q000601:surgery; D008567:Membranes, Artificial; D008903:Minerals / Q000627:therapeutic use; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D011138:Polytetrafluoroethylene; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D014025:Titanium
chemical_list: D043925:Angiogenesis Inducing Agents; C077540:Bio-Oss; D018786:Bone Substitutes; D015921:Dental Implants; D008567:Membranes, Artificial; D008903:Minerals; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D000077214:Becaplermin; D011138:Polytetrafluoroethylene; D014025:Titanium