title: Conceptualizing antiretroviral adherence in Beijing, China.
abstract: International health experts agree that China is on the verge of an AIDS crisis. In response, the Chinese government initiated the "Four Frees and One Care" policy in 2003 to decrease economic barriers and increase access to antiretroviral therapies for people with HIV. However, long-term treatment success requires not only access, but high rates of medication adherence. This qualitative interview study with 29 persons receiving HIV care at Beijing's Ditan Hospital identified barriers to and facilitators of medication adherence. The interviews were guided by an a priori conceptual model of adherence with four components: access, knowledge about medications, motivation, and proximal cues to action. Barriers to adherence were related to stigma and fear of discrimination; the medications themselves (including side-effects and complicated dosing regimens); and other economic issues (i.e. costs of transportation, lab tests and hospitalizations). Facilitators included participants' strong will to live, use of electronic reminders and family support. These results support the conceptual model and suggest that successful interventions must minimize stigma as it negatively affects all components of the model for adherence.
authors.affiliation: Department of Medical History and Ethics, University of Washington, Seattle, USA.
authors.forename: H
authors.initials: H
authors.lastname: Starks
authors.forename: J
authors.initials: J
authors.lastname: Simoni
authors.forename: H
authors.initials: H
authors.lastname: Zhao
authors.forename: B
authors.initials: B
authors.lastname: Huang
authors.forename: K
authors.initials: K
authors.lastname: Fredriksen-Goldsen
authors.forename: C
authors.initials: C
authors.lastname: Pearson
authors.forename: W-T
authors.initials: WT
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Lu
authors.forename: F
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology; D015497:HIV-1; D007722:Health Knowledge, Attitudes, Practice; D006297:Health Services Accessibility / Q000592:standards; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D009042:Motivation; D011287:Prejudice; D036301:Qualitative Research; D014342:Truth Disclosure
chemical_list: D044966:Anti-Retroviral Agents