title: Thrombophilic polymorphisms in Israel.
abstract: Three thrombophilic polymorphisms, FV G1691A, FII G20210A and MTHFR C677T were investigated in Israeli populations by FRET, (fluorescence resonance energy transfer) real-time PCR. We observe extensive variability in the frequencies of each of the polymorphisms, as has been observed in the study of other polymorphisms in these populations. Very high allele frequencies for FV G1691A (the highest 0.087 in Turkish and Greek Jews) and FII G20210A (the highest 0.061 in Georgian Jews) in some of the Israeli populations justify a clinical investigation to assess their risk for venous thrombosis. Principal Coordinates Analysis demonstrates that the Jewish populations are interspersed among the non-Jewish populations. The resemblance of some Jewish populations to certain non-Jewish populations coincides with findings based on classical markers.
authors.affiliation: Department of Haematology and Genetic Pathology, School of Medicine, Flinders University, Adelaide, Australia. avshalom.zoossmann-diskin@flinders.edu.au
authors.forename: Avshalom
authors.initials: A
authors.lastname: Zoossmann-Diskin
authors.forename: Ephraim
authors.initials: E
authors.lastname: Gazit
authors.forename: Leah
authors.initials: L
authors.lastname: Peleg
authors.forename: Mordechai
authors.initials: M
authors.lastname: Shohat
authors.forename: David
authors.initials: D
authors.lastname: Turner
mesh_terms: D005165:Factor V / Q000235:genetics*; D031541:Fluorescence Resonance Energy Transfer; D005828:Genetics, Population; D006801:Humans; D007557:Israel; D007585:Jews / Q000235:genetics*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011516:Prothrombin / Q000235:genetics*; D019851:Thrombophilia / Q000208:ethnology / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)