Are serum lipids measured on stroke admission prognostic?
BACKGROUND
It has been hypothesized that serum lipids measured in the early period of stroke are predictive of stroke severity and outcome. The optimal time for lipid measurement is not established. We explored whether lipid profile assessed within the first 24 h after stroke onset: (i) differs from that in stroke-free individuals; (ii) differs between stroke subtypes; and (iii) is predictive of stroke severity and outcome.


METHODS
We prospectively enrolled 70 acute ischemic stroke patients who presented to the Stroke Unit within 24 h of the onset of stroke symptoms, and 68 stroke-free control subjects.


RESULTS
Triglycerides (p<0.001) and high-density lipoprotein (HDL) cholesterol (p<0.001) were significantly lower in patients than in controls. HDL cholesterol was different across stroke subtypes classified according to the Trial of ORG 10172 in Acute Stroke Treatment scale (p=0.035). Patients with more severe stroke had higher serum triglycerides (odds ratio 2.755; p=0.030).


CONCLUSIONS
Serum triglycerides might serve as a prognostic marker in acute stroke patients.
Simundic
Ana-Maria
AM
Clinical Institute of Chemistry, Department of Molecular Diagnostics, Sestre milosrdnice University Hospital, Zagreb, Croatia. am.simundic@gmail.com
Nikolac
Nora
N
Topic
Elizabeta
E
Basic-Kes
Vanja
V
Demarin
Vida
V
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010343:Patient Admission; D011379:Prognosis; D020521:Stroke / Q000097:blood* / Q000175:diagnosis*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D008055:Lipids; D014280:Triglycerides