Perianal Paget's disease treated with wide excision and gluteal skin flap reconstruction: report of a case and review of the literature.
BACKGROUND
Paget's disease of the anus is a rare perianal disorder. The condition is often associated with underlying invasive carcinoma and the prognosis is poor when underlying adenocarcinoma is present.


METHODS
We report the case of a 72-year-old woman suffering from a two-year history of perianal itching, bleeding, and irritation. Perianal Paget's disease was confirmed by histopathologic demonstration of Paget's cells from a biopsy. Synchronous malignancy and metastasis were excluded.


RESULTS
A first-stage operation consisted of a wide excisional biopsy with frozen section margin assessment. Permanent sections confirmed absence of invasive carcinoma and clear margins. Four days after wide excision, bilateral gluteal skin flap reconstruction was performed with a temporary diverting colostomy. No adjuvant therapy was necessary, and after one-year follow-up, the patient remains disease free.


CONCLUSIONS
Perianal Paget's disease continues to pose problems in diagnosis and treatment. Our case report of perianal Paget's disease shows one method of management for advanced non invasive disease.
Gaertner
Wolfgang B
WB
Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA. gaert015@umn.edu
Hagerman
Gonzalo F
GF
Goldberg
Stanley M
SM
Finne
Charles O
CO
D000368:Aged; D001005:Anus Neoplasms / Q000473:pathology / Q000601:surgery*; D002081:Buttocks; D005260:Female; D006801:Humans; D010145:Paget Disease, Extramammary / Q000473:pathology / Q000601:surgery*; D013524:Surgical Flaps