title: Immunological status of the stomach in inflammatory bowel disease--comparison between ulcerative colitis and Crohn's disease.
abstract: OBJECTIVE
  Ulcerative colitis (UC) mainly affects the colon and rectum, whereas the chronic inflammatory process in Crohn's disease (CD) can affect any part of the gastrointestinal tract. Recently, however, upper gastrointestinal lesions have been reported in UC patients. In this study, we investigated the immunological status of the stomach in UC or CD patients.
  
  
  METHODS
  26 patients each with UC, CD or functional dyspepsia (FD) underwent diagnostic upper gastrointestinal endoscopy, and biopsy specimens were obtained from the gastric antrum. The contents of interleukin (IL)-6 and IL-8 in the organ culture supernatants of antral mucosal tissues were measured with enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Endoscopically abnormal findings in the stomach were more frequent in CD than in UC or FD patients. Mononuclear cell infiltration and IL-6 production in the gastric antrum did not significantly differ between UC and FD patients, but were higher in those with CD. There was no significant difference in neutrophil infiltration or IL-8 production between UC, CD, and FD patients.
  
  
  CONCLUSIONS
  UC patients did not show the immunological abnormalities in the stomach seen in CD patients.
authors.affiliation: Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan. takafumiando-gi@umin.ac.jp
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ando
authors.forename: Osamu
authors.initials: O
authors.lastname: Watanabe
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nobata
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ishiguro
authors.forename: Osamu
authors.initials: O
authors.lastname: Maeda
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ishikawa
authors.forename: Motofusa
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Shinya
authors.initials: S
authors.lastname: Kondo
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kato
authors.forename: Naoki
authors.initials: N
authors.lastname: Ohmiya
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Niwa
authors.forename: Hidemi
authors.initials: H
authors.lastname: Goto
mesh_terms: D000293:Adolescent; D000328:Adult; D003093:Colitis, Ulcerative / Q000276:immunology*; D003424:Crohn Disease / Q000276:immunology*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis; D016209:Interleukin-8 / Q000096:biosynthesis; D008297:Male; D020556:Neutrophil Infiltration; D009924:Organ Culture Techniques; D013270:Stomach / Q000276:immunology*
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8