Synthesis of bone formation deriving biosilanes.
Six silane coupling agents having amide group (biosilanes) were synthesized with the aim to construct the material surface that allows cells to be compatible with it without their destruction. These agents were expected to make a soft landing to cytoplasm through the hydrogen bonding between their amide groups and cells. Evaluations of cell affinity using glass substrates modified with the synthesized biosilanes revealed that many cells remain on the modified glass plate. In addition, the implantation into the body of immunodeficient mouse of a composite material composed of porous hydroxyapatite and osteoblast showed the formation of a bone-like structure.
Yoshino
Norio
N
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, 12-1 Ichigaya-Funagawara, Shinjuku, Tokyo 162-0826, Japan. yoshino@ci.kagu.tus.ac.jp
Nakajima
Kaori
K
Nakamura
Keisuke
K
Kondo
Yukishige
Y
Ohashi
Katsura
K
Nihei
Tomotaro
T
Saito
Masahiro
M
Teranaka
Toshio
T
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002470:Cell Survival; D003593:Cytoplasm; D017886:Durapatite / Q000737:chemistry; D005898:Glass / Q000737:chemistry; D006860:Hydrogen Bonding; D008156:Luciferases / Q000378:metabolism; D049449:Luminescence; D051379:Mice; D016513:Mice, SCID; D010006:Osteoblasts / Q000166:cytology; D010012:Osteogenesis; D012821:Silanes / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
D001672:Biocompatible Materials; D012821:Silanes; D017886:Durapatite; D008156:Luciferases; C071717:trimethoxysilane