title: Brominated diterpenes with antibacterial activity from the red alga Sphaerococcus coronopifolius.
abstract: Four new brominated diterpenes (1, 2, 4, 5), along with two previously reported metabolites (3, 6), were isolated from the organic extract of Sphaerococcus coronopifolius, collected in Palaiokastritsa Bay at the west coast of Corfu Island. The structures of the new products, as well as their relative configuration, were established by means of spectroscopic data analyses, including 2D NMR experiments. The isolated metabolites were evaluated for their antibacterial activity against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) with MICs in the range 0.5-128 microg/mL.
authors.affiliation: Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
authors.forename: Vangelis
authors.initials: V
authors.lastname: Smyrniotopoulos
authors.forename: Constantinos
authors.initials: C
authors.lastname: Vagias
authors.forename: M Mukhlesur
authors.initials: MM
authors.lastname: Rahman
authors.forename: Simon
authors.initials: S
authors.lastname: Gibbons
authors.forename: Vassilios
authors.initials: V
authors.lastname: Roussis
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001966:Bromine / Q000737:chemistry*; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D009682:Magnetic Resonance Spectroscopy; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D000461:Rhodophyta / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D001966:Bromine