title: Disorders of sex development: hormonal management in adolescence.
abstract: Hormonal treatment represents the principal aspect of clinical management of people with disorders of sex development (DSD) from adolescence onwards. In fact, individuals with DSD may require sex steroid replacement to induce secondary sex characteristics, to optimize bone mass accrual, and to promote physical and social well-being. Testosterone is the main hormone for treatment in males and estrogens in females. The optimal regimens for sex steroid substitutive therapy in subjects with DSD should be better defined in multi-center prospective studies. Bone health remains a crucial aspect in the management of these persons, but few sound data are available to guide clinical practice.
authors.affiliation: Adolescent Medicine, 2nd Pediatric Unit, Department of Obstetrics, Gynecology and Pediatrics, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy. s.bertelloni@med.unipi.it
authors.forename: Silvano
authors.initials: S
authors.lastname: Bertelloni
authors.forename: Eleonora
authors.initials: E
authors.lastname: Dati
authors.forename: Giampiero I
authors.initials: GI
authors.lastname: Baroncelli
mesh_terms: D000293:Adolescent; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D012734:Disorders of Sex Development / Q000188:drug therapy* / Q000378:metabolism; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D013739:Testosterone / Q000008:administration & dosage*
chemical_list: D004967:Estrogens; D013739:Testosterone