title: Acute interstitial pneumonia in siblings: a case report.
abstract: Acute interstitial pneumonia (AIP) is a rapidly progressive condition of unknown cause that occurs in a previously healthy individual and produces the histologic findings of diffuse alveolar damage. Since the term AIP was first introduced in 1986, there have been very few case reports of AIP in children. Here we present a case of AIP in a 3-yr-old girl whose other two siblings showed similar radiologic findings. The patient was confirmed to have AIP from autopsy showing histological findings of diffuse alveolar damage and proliferation of fibroblasts. Her 3-yr-old brother was also clinically and radiologically highly suspected as having AIP, and the other asymptomatic 8-yr-old sister was radiologically suspected as having AIP.
authors.affiliation: Department of Pediatrics and Institution of Allergy, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Seung Yeon
authors.initials: SY
authors.lastname: Kwon
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Myung Hyun
authors.initials: MH
authors.lastname: Sohn
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Kim
authors.forename: Myung Joon
authors.initials: MJ
authors.lastname: Kim
authors.forename: Sang-Ho
authors.initials: SH
authors.lastname: Cho
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D005192:Family Health; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging / Q000473:pathology; D035781:Siblings; D014057:Tomography, X-Ray Computed