title: Incorporation of the bone marker carboxy-terminal telopeptide of type-1 collagen improves prognostic information of the International Staging System in newly diagnosed symptomatic multiple myeloma.
abstract: Several prognostic markers, including parameters of tumor burden and cytogenetics, were adopted to identify high-risk patients in multiple myeloma (MM). Recently, the International Staging System (ISS), including beta2-microglobulin (beta2M) and albumin, was introduced for patients with symptomatic MM. As bone disease is a hallmark of MM, we investigated the prognostic impact of the bone resorption marker carboxy-terminal telopeptide of type-1 collagen (ICTP) in combination with ISS, beta2M, albumin, deletion of chromosome 13 and high-dose therapy (HDT) in 100 patients with newly diagnosed symptomatic MM. beta2M alone, albumin alone, ISS, HDT, del(13q14) and ICTP were significant prognostic factors for overall survival (OS). In a multivariate analysis, ICTP was the most powerful prognostic factor (log-rank P<0.001, hazard ratio: ninefold increase). ICTP clearly separated two subgroups with a good and a worse prognosis within each of the three ISS stages (ISS I: P=0.027, ISS II: P=0.022, ISS III: P=0.013). Incorporation of ICTP in a combined ICTP-ISS score significantly (P<0.001) separated four risk groups with a 5-year OS rate of 95, 64, 46 and 22%, [corrected] respectively. These data demonstrate for the first time that the inclusion of the collagen-I degradation product ICTP, as a biomarker of bone resorption, adds to the prognostic value of ISS.
authors.affiliation: Department of Hematology and Oncology, Charité-Universitätsmedizin, Berlin, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Jakob
authors.forename: J
authors.initials: J
authors.lastname: Sterz
authors.forename: P
authors.initials: P
authors.lastname: Liebisch
authors.forename: M
authors.initials: M
authors.lastname: Mieth
authors.forename: J
authors.initials: J
authors.lastname: Rademacher
authors.forename: A
authors.initials: A
authors.lastname: Goerke
authors.forename: U
authors.initials: U
authors.lastname: Heider
authors.forename: C
authors.initials: C
authors.lastname: Fleissner
authors.forename: M
authors.initials: M
authors.lastname: Kaiser
authors.forename: I
authors.initials: I
authors.lastname: von Metzler
authors.forename: C
authors.initials: C
authors.lastname: Müller
authors.forename: O
authors.initials: O
authors.lastname: Sezer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D001862:Bone Resorption / Q000175:diagnosis; D024042:Collagen Type I / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000401:mortality; D009367:Neoplasm Staging / Q000379:methods* / Q000592:standards; D010455:Peptides / Q000032:analysis; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide