title: Radiologic outcomes in children with chronic rhinosinusitis and ostiomeatal complex obstruction after medical management.
abstract: BACKGROUND
  The presence of ostiomeatal complex obstruction can be a key component in chronic rhinosinusitis, and the medical management of this condition has not been well studied, particularly in children.
  
  
  OBJECTIVE
  To compare the effectiveness of antibiotics, intranasal topical corticosteroids, and oral systemic corticosteroids on radiologic outcomes in children with chronic rhinosinusitis and ostiomeatal complex obstruction.
  
  
  METHODS
  We reviewed the reports of 1,741 computed tomography scans performed on children at Alfred I. duPont Hospital for Children, Wilmington, Delaware, from October 1, 2001, through February 28, 2007, identifying those patients who had 2 scans performed at least 2 weeks apart but no more than 6 months apart. Forty-five instances involving abnormal ostiomeatal complex anatomy documented on the initial study with obtainable treatment information were selected for further review.
  
  
  RESULTS
  Of the 3 treatment modalities examined, only oral systemic corticosteroids (P = .03) and intranasal topical corticosteroids (P = .03) were found to provide significant independent contributions to predicting treatment outcome, with the former promoting a positive outcome and the latter predicting a negative outcome. The model that contained just these 2 factors also provided a significant fit to the outcome data (P = .01), producing a diminished rate of improvement expected from a combination of positive and negative influences. Neither antibiotics nor any other combination of modalities contributed to a significant improvement in model fit.
  
  
  CONCLUSIONS
  The use of oral systemic corticosteroids was found to be the only beneficial intervention, with regard to radiologic improvement, in the treatment of ostiomeatal complex obstruction in children.
authors.affiliation: Berkshire Allergy and Asthma Center, Inc., Wyomissing, Pennsylvania, USA.
authors.forename: Edward W
authors.initials: EW
authors.lastname: Skorpinski
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Vannelli
authors.forename: Ejaz
authors.initials: E
authors.lastname: Yousef
authors.forename: Timothy
authors.initials: T
authors.lastname: Brunell
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: McGeady
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D006801:Humans; D007223:Infant; D008297:Male; D015508:Nasal Obstruction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging* / Q000473:pathology; D012189:Retrospective Studies; D012220:Rhinitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents