Non-invasive techniques for assessing postoperative recurrence in Crohn's disease.
Postoperative recurrence after ileo-colonic resection is a feature of Crohn's Disease (CD), almost 73% of patients show endoscopic recurrence at 1 year and 90% at 3 years. After surgical resection for CD, symptoms may be related to the surgical resection itself. Moreover, the development of an early severe endoscopic recurrence within 1 year represents a risk factor for early clinical recurrence. On the basis of these observations, the early detection and assessment of asymptomatic endoscopic recurrence may allow a timely and appropriate treatment of CD patients after ileo-colonic resection. At this purpose, conventional colonoscopy with ileoscopy currently represents the gold standard for assessing CD recurrence, graded according to the Rutgeerts' score. Lesions compatible with CD recurrence can be also detected by conventional radiology, including small bowel follow through and enema, both associated with a high radiation exposure. Due to the ineluctable course of CD after resection, and to the need of a proper follow up for assessing CD recurrence, several alternative, non invasive techniques have been searched in order to assess the post-operative recurrence, including: faecal alpha 1-antitrypsin clearance, faecal calprotectin, 99Tc-HMPAO scintigraphy, virtual colonoscopy, ultrasonography and, more recently, wireless capsule endoscopy (WCE) and Small Intestine Contrast Ultrasonography (SICUS). Among these, current evidences suggest that in experienced hands, ultrasound examination by SICUS represents a non-invasive technique useful for assessing recurrence in CD patients under regular follow up after surgery. The same findings are suggested for WCE, although the impact risk related to the recurrence or to the surgical anastomosis itself limits the use of this non-invasive technique for assessing CD recurrence after surgery.
Biancone
L
L
Departments of Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy. biancone@med.uniroma2.it
Onali
S
S
Calabrese
E
E
Petruzziello
C
C
Zorzi
F
F
Condino
G
G
Sica
G S
GS
Pallone
F
F
D015415:Biomarkers / Q000378:metabolism; D053704:Capsule Endoscopy; D003287:Contrast Media; D003424:Crohn Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000473:pathology; D005243:Feces / Q000737:chemistry; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000378:metabolism; D012008:Recurrence; D014463:Ultrasonography; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D015415:Biomarkers; D003287:Contrast Media; D039841:Leukocyte L1 Antigen Complex; D000515:alpha 1-Antitrypsin