title: Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
abstract: Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.
authors.affiliation: Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Barrett
authors.forename: Sarah
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authors.lastname: Hansoul
authors.forename: Dan L
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authors.lastname: Nicolae
authors.forename: Judy H
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authors.forename: Richard H
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authors.lastname: Rioux
authors.forename: Steven R
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authors.lastname: Silverberg
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authors.forename: Alain
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authors.lastname: Bitton
authors.forename: Themistocles
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authors.lastname: Dassopoulos
authors.forename: Lisa Wu
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authors.forename: L Philip
authors.initials: LP
authors.lastname: Schumm
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authors.forename: Stephan R
authors.initials: SR
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authors.forename: Cécile
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authors.lastname: Zelenika
authors.forename: Denis
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authors.lastname: Franchimont
authors.forename: Jean-Pierre
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authors.forename: Martine
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authors.lastname: de Vos
authors.forename: Severine
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authors.lastname: Vermeire
authors.forename: Edouard
authors.initials: E
authors.lastname: Louis
authors.forename: Lon R
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authors.lastname: Cardon
authors.forename: Carl A
authors.initials: CA
authors.lastname: Anderson
authors.forename: Hazel
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authors.lastname: Drummond
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authors.lastname: Nimmo
authors.forename: Tariq
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authors.lastname: Ahmad
authors.forename: Natalie J
authors.initials: NJ
authors.lastname: Prescott
authors.forename: Clive M
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authors.lastname: Onnie
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Fisher
authors.forename: Jonathan
authors.initials: J
authors.lastname: Marchini
authors.forename: Jilur
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authors.forename: Suzannah
authors.initials: S
authors.lastname: Bumpstead
authors.forename: Rhian
authors.initials: R
authors.lastname: Gwilliam
authors.forename: Mark
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authors.lastname: Tremelling
authors.forename: Panos
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authors.lastname: Deloukas
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authors.lastname: Mansfield
authors.forename: Derek
authors.initials: D
authors.lastname: Jewell
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authors.initials: J
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authors.forename: Christopher G
authors.initials: CG
authors.lastname: Mathew
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authors.lastname: Parkes
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authors.lastname: Georges
authors.forename: Mark J
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mesh_terms: D003424:Crohn Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D040641:Quantitative Trait Loci