Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity.
Sulfur mustard (SM) is a chemical warfare agent leading to severe blistering of skin and mucosal surfaces, and as a long-term effect, to an increased risk for malignancies. At the molecular level, SM acts as a bifunctional alkylating agent, leading to DNA mono-adducts and di-adducts. This review is focussed on the role of poly(ADP-ribosyl)ation in the cell and tissue responses to SM-induced damage and potential role of inhibitors of poly(ADP-ribosyl)ation as therapeutic agents for SM injury.
Debiak
Malgorzata
M
Molecular Toxicology Group, Department of Biology, Box X911, University of Konstanz, 78457 Konstanz, Germany.
Kehe
Kai
K
Bürkle
Alexander
A
D000478:Alkylation; D017209:Apoptosis / Q000187:drug effects; D002619:Chemical Warfare Agents / Q000737:chemistry / Q000378:metabolism / Q000506:poisoning*; D004247:DNA / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D018736:DNA Adducts / Q000737:chemistry; D004260:DNA Repair; D004791:Enzyme Inhibitors; D006801:Humans; D009151:Mustard Gas / Q000737:chemistry / Q000378:metabolism / Q000506:poisoning*; D011041:Poisoning / Q000201:enzymology* / Q000209:etiology; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000502:physiology*; D012869:Skin Absorption
D002619:Chemical Warfare Agents; D018736:DNA Adducts; D004791:Enzyme Inhibitors; D004247:DNA; C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; D009151:Mustard Gas