title: Benign transient hyperphosphatasemia associated with Epstein-Barr virus enteritis in a pediatric liver transplant patient: a case report.
abstract: Transient hyperphosphatasemia was found in a 3-year-old male liver transplant recipient. The condition was associated with diarrheal disease due to the Epstein-Barr virus (EBV). Immunosuppression was tapered and valganciclovir prescribed for 3 months, after which the diarrhea resolved and the EBV polymerase chain reaction assays became negative. After 6 months, alkaline phosphatase levels normalized. Isolated elevation of alkaline phosphatase in conjunction with enteric infection is a rare condition. No further diagnostic or therapeutic interventions except treatment of the underlying infection are needed, as this has been shown to be a benign, transient condition.
authors.affiliation: Department of Surgery, Division of Transplantation, University of Virginia Health Services, Charlottesville, Virginia, USA.
authors.forename: T
authors.initials: T
authors.lastname: Hranjec
authors.forename: H
authors.initials: H
authors.lastname: Bonatti
authors.forename: A L
authors.initials: AL
authors.lastname: Roman
authors.forename: C
authors.initials: C
authors.lastname: Sifri
authors.forename: S M
authors.initials: SM
authors.lastname: Borowitz
authors.forename: B H
authors.initials: BH
authors.lastname: Barnes
authors.forename: T R
authors.initials: TR
authors.lastname: Flohr
authors.forename: T L
authors.initials: TL
authors.lastname: Pruett
authors.forename: R G
authors.initials: RG
authors.lastname: Sawyer
authors.forename: T M
authors.initials: TM
authors.lastname: Schmitt
mesh_terms: D000328:Adult; D002675:Child, Preschool; D002779:Cholestasis / Q000601:surgery*; D004751:Enteritis / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005190:Family; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016031:Liver Transplantation / Q000276:immunology; D019520:Living Donors; D008297:Male; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D010760:Phosphorus Metabolism Disorders / Q000175:diagnosis* / Q000201:enzymology / Q000209:etiology; D011183:Postoperative Complications / Q000175:diagnosis*; D016559:Tacrolimus / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D010744:Phosphoric Monoester Hydrolases; D016559:Tacrolimus