The ongoing saga of sirtuins and aging.
Sirtuins are known to slow aging in simple eukaryotes; however, viewing mammalian sirtuins as antiaging proteins may be overly simplistic. In this issue of Cell Metabolism, Li et al. (2008) provide evidence that SirT1 has properties consistent with both pro- and antiaging functions in mice.
Kaeberlein
Matt
M
Department of Pathology, University of Washington, Seattle, WA 98195-7470, USA. kaeber@u.washington.edu
D000375:Aging; D000818:Animals; D006801:Humans; D008322:Mammals; D056564:Sirtuin 1; D037761:Sirtuins / Q000502:physiology*
C470545:Sirt1 protein, mouse; D056564:Sirtuin 1; D037761:Sirtuins