title: Chemical constituents of Aeschynanthus bracteatus and their weak anti-inflammatory activities.
abstract: Chemical examination of the EtOAc extract from the aerial parts of Aeschynanthus bracteatus led to isolation of four phenylethanol glycosides, aeschynanthosides A-D (1-4), and 55 known constituents, including 8 phenylethanoids, 23 phenols, 5 lignans, 7 flavonoids, 9 terpenoids, and 4 others. Their structures were elucidated mainly by detailed spectroscopic studies and comparison with published data. All 59 compounds were isolated for the first time from an Aeschynanthus species. The isolates were also tested for inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages. Aeschynanthoside D (4) and naringenin (41), within the concentration arrange tested (50-100 microg/mL), showed very weak dose-dependent effects with the inhibition rate of 24.2%, 35.4%, 66.0%, and 9.5%, 40.1%, 65.0%, respectively, relative to positive controls.
authors.affiliation: Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Heilongtan, Kunming 650204, PR China.
authors.forename: Su-Mei
authors.initials: SM
authors.lastname: Li
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Yang
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Lin
authors.initials: L
authors.lastname: Feng
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Hua-Wu
authors.initials: HW
authors.lastname: Zeng
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Liu
authors.forename: Jun-Mian
authors.initials: JM
authors.lastname: Tian
authors.forename: Ya-Na
authors.initials: YN
authors.lastname: Shi
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Long
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D009569:Nitric Oxide