title: Effect of acarbose on the increased plasma concentration of uric acid induced by sucrose ingestion.
abstract: Sucrose is converted fructose and glucose, which may increase plasma uric acid concentration (pUA) through increased purine degradation and/or decreased uric acid (UA) excretion. To investigate effects of acarbose, an inhibitor of alpha-glucosidase, on the increased pUA from sucrose administration, we measured pUA and urinary UA excretion in 6 healthy subjects before and after administering sucrose, with and without co-administration of acarbose. Sucrose raised pUA by 10% (p < 0.01). However, excretion and fractional clearance of UA were unchanged. Sucrose and acarbose coadministration also increased pUA, but less than did sucrose alone (sucrose: 4.9 to 5.4 mg/dl; sucrose + acarbose, 4.7 to 4.9 mg/dl, p < 0.05) without changes in urinary excretion and fractional clearance of UA. Acarbose appears to attenuate the rise in pUA by sucrose ingestion by inhibiting sucrose absorption.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan. moriwaki@hyo-med.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Moriwaki
authors.forename: T
authors.initials: T
authors.lastname: Inokuchi
authors.forename: T
authors.initials: T
authors.lastname: Ka
authors.forename: A
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Z
authors.initials: Z
authors.lastname: Tsutsumi
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D020909:Acarbose / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D004435:Eating; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007328:Insulin / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008297:Male; D011687:Purines / Q000097:blood; D013395:Sucrose / Q000008:administration & dosage / Q000494:pharmacology*; D014527:Uric Acid / Q000097:blood*
chemical_list: D001786:Blood Glucose; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007328:Insulin; D011687:Purines; D014527:Uric Acid; D019344:Lactic Acid; D013395:Sucrose; D020909:Acarbose