Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.
Barrett
Jeffrey C
JC
Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Hansoul
Sarah
S
Nicolae
Dan L
DL
Cho
Judy H
JH
Duerr
Richard H
RH
Rioux
John D
JD
Brant
Steven R
SR
Silverberg
Mark S
MS
Taylor
Kent D
KD
Barmada
M Michael
MM
Bitton
Alain
A
Dassopoulos
Themistocles
T
Datta
Lisa Wu
LW
Green
Todd
T
Griffiths
Anne M
AM
Kistner
Emily O
EO
Murtha
Michael T
MT
Regueiro
Miguel D
MD
Rotter
Jerome I
JI
Schumm
L Philip
LP
Steinhart
A Hillary
AH
Targan
Stephan R
SR
Xavier
Ramnik J
RJ
Libioulle
Cécile
C
Sandor
Cynthia
C
Lathrop
Mark
M
Belaiche
Jacques
J
Dewit
Olivier
O
Gut
Ivo
I
Heath
Simon
S
Laukens
Debby
D
Mni
Myriam
M
Rutgeerts
Paul
P
Van Gossum
André
A
Zelenika
Diana
D
Franchimont
Denis
D
Hugot
Jean-Pierre
JP
de Vos
Martine
M
Vermeire
Severine
S
Louis
Edouard
E
Cardon
Lon R
LR
Anderson
Carl A
CA
Drummond
Hazel
H
Nimmo
Elaine
E
Ahmad
Tariq
T
Prescott
Natalie J
NJ
Onnie
Clive M
CM
Fisher
Sheila A
SA
Marchini
Jonathan
J
Ghori
Jilur
J
Bumpstead
Suzannah
S
Gwilliam
Rhian
R
Tremelling
Mark
M
Deloukas
Panos
P
Mansfield
John
J
Jewell
Derek
D
Satsangi
Jack
J
Mathew
Christopher G
CG
Parkes
Miles
M
Georges
Michel
M
Daly
Mark J
MJ
D003424:Crohn Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D040641:Quantitative Trait Loci