APOBEC3G encapsidation into HIV-1 virions: which RNA is it?
APOBEC3G is a cytidine deaminase with potent antiviral activity. The protein deaminates single-stranded DNA but is known to bind cellular and viral RNAs. There is increasing evidence that RNA binding of APOBEC3G is important for packaging into viral particles. However, there is no consensus yet on the type of RNA involved.
Strebel
Klaus
K
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4/312, Bethesda, MD 20892-0460, USA. kstrebel@niaid.nih.gov
Khan
Mohammad A
MA
D000071480:APOBEC-3G Deaminase; D003564:Cytidine Deaminase / Q000378:metabolism*; D015497:HIV-1 / Q000378:metabolism*; D006801:Humans; D020733:RNA, Small Cytoplasmic / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism*; D018271:Signal Recognition Particle / Q000378:metabolism*; D014771:Virion / Q000378:metabolism*
C115990:7SL RNA; D020733:RNA, Small Cytoplasmic; D012367:RNA, Viral; D018271:Signal Recognition Particle; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase