title: Applications of enantioselective carbolithiation of ortho-substituted beta-methylstyrenes.
abstract: The enantioselective carbolithiation of ortho-substituted (E)-beta-methylstyrenes provides access to chiral lithiated intermediates with broad synthetic potential. Specifically, beta-methylstyrenes with o-aminomethyl, ether, and oxazoline groups have been employed in the synthesis of chiral aromatics and heteroaromatics such as isoquinolines, isoquinolinones, benzofurans, and isobenzofuranones.
authors.affiliation: Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Anne-Marie L
authors.initials: AM
authors.lastname: Hogan
authors.forename: Thomas
authors.initials: T
authors.lastname: Tricotet
authors.forename: Alastair
authors.initials: A
authors.lastname: Meek
authors.forename: Shaista S
authors.initials: SS
authors.lastname: Khokhar
authors.forename: Donal F
authors.initials: DF
authors.lastname: O'Shea