Protein phosphatase 2A regulatory subunits and cancer.
The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an integral role in the regulation of a number of major signaling pathways whose deregulation can contribute to cancer. The specificity and activity of PP2A are highly regulated through the interaction of a family of regulatory B subunits with the substrates. Accumulating evidence indicates that PP2A acts as a tumor suppressor. In this review we summarize the known effects of specific PP2A holoenzymes and their roles in cancer relevant pathways. In particular we highlight PP2A function in the regulation of MAPK and Wnt signaling.
Eichhorn
Pieter J A
PJ
Division of Molecular Carcinogenesis, Center for Cancer Genomics and Center for Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Creyghton
Menno P
MP
Bernards
René
R
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology; D008954:Models, Biological; D009369:Neoplasms / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism; D054648:Protein Phosphatase 2 / Q000378:metabolism / Q000502:physiology*; D021122:Protein Subunits / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D051153:Wnt Proteins / Q000378:metabolism / Q000502:physiology
D021122:Protein Subunits; D051153:Wnt Proteins; D054648:Protein Phosphatase 2