Cytotoxic, antioxidant activities and structure activity relationship of some newly synthesized terpenoidal oxaliplatin analogs.
The terpenoidal oxaliplatin derivatives (6) and (12) were newly synthesized using 2beta,3alpha-dihydroxy-11-oxo-18beta-olean-12-ene-30-oic acid (1) and 2alpha,2beta-dihydroxy-18beta-ursan-12-ene-28-oic acid (7) as starting materials. The synthesized compounds were evaluated for their cytotoxicity and antioxidant activities and were compared to Oxaliplatin and vitamin C as positive controls. Some of the compounds exhibited better cytotoxicity and antioxidant activities than the reference controls. The detailed synthesis, spectroscopic data, toxicity (LD(50)) and pharmacological screening for the synthesized compounds were reported.
Amr
Abd El-Galil E
Ael-G
Applied Organic Chemistry Department, National Research Centre, El Tahrir Street, Dokki, Cairo, Egypt. aamr1963@yahoo.com
Ali
Korany A
KA
Abdalla
Mohamed M
MM
D000970:Antineoplastic Agents / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000077150:Oxaliplatin; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship; D013729:Terpenes
D000970:Antineoplastic Agents; D000975:Antioxidants; D009944:Organoplatinum Compounds; D013729:Terpenes; D000077150:Oxaliplatin