title: Safety of unilateral antegrade cerebral perfusion at 22 degrees C systemic hypothermia.
abstract: BACKGROUND
  The superiority of antegrade cerebral perfusion (ACP) in aortic surgery is widely accepted, but the sufficiency of unilateral cerebral perfusion and the optimal systemic temperature during the operation are still controversial.
  
  
  METHODS
  Thirty patients who underwent operation with unilateral ACP at a systemic temperature of 22 degrees C between January 2005 and September 2007 were included in this study. The mean age (+/-SD) of the patients was 58 +/- 11 years, and 21 (70%) of the patients were male. The indication for surgery was acute type A aortic dissection in 14 patients (47%), degenerative aortic aneurysm in 9 patients (30%), dissecting aortic aneurysm in 6 patients (20%), and intramural hematoma in 1 patient (3%). Supracoronary ascending aorta replacement was performed in 13 patients (43%). Eight patients (27%) underwent ascending aorta and hemiarch replacement. The Bentall procedure was performed with hemiarch replacement in 3 patients (10%). Three patients (10%) underwent total aortic arch replacement, and 2 patients (7%) underwent the Bentall procedure. The ascending aorta, aortic arch, and descending aorta were replaced in 1 patient (3%).
  
  
  RESULTS
  Hospital mortality was limited to 1 patient (3.3%). A permanent or transient neurologic deficit was not detected in any of the survivors. The mean cardiopulmonary bypass, aortic cross-clamp, and ACP times were 144 +/- 40 minutes, 82 +/- 28 minutes, and 30 +/- 11 minutes, respectively. The mean mechanical ventilation time was 18 +/- 9 hours. The mean stay in the intensive care unit was 2.3 +/- 1.1 days, and the mean hospital stay was 12 +/- 6 days.
  
  
  CONCLUSIONS
  Unilateral ACP with systemic hypothermia at 22 degrees C is safe and has satisfactory clinical results. Establishing ACP via cannulation of the right axillary artery is fast and simple. The presence of fewer cannulas in the operation field provides an operative condition as convenient as the deep hypothermic circulatory arrest technique.
authors.affiliation: Department of Cardiovascular Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey. sanioglu@gmail.com
authors.forename: Soner
authors.initials: S
authors.lastname: Sanioglu
authors.forename: Onur
authors.initials: O
authors.lastname: Sokullu
authors.forename: Batuhan
authors.initials: B
authors.lastname: Ozay
authors.forename: A Umit
authors.initials: AU
authors.lastname: Gullu
authors.forename: Murat
authors.initials: M
authors.lastname: Sargin
authors.forename: Sebnem
authors.initials: S
authors.lastname: Albeyoglu
authors.forename: Ayca
authors.initials: A
authors.lastname: Ozgen
authors.forename: Fuat
authors.initials: F
authors.lastname: Bilgen
mesh_terms: D001014:Aortic Aneurysm / Q000150:complications* / Q000601:surgery*; D002545:Brain Ischemia / Q000209:etiology* / Q000517:prevention & control*; D002548:Cerebral Revascularization / Q000379:methods*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D015424:Reperfusion / Q000379:methods*; D016896:Treatment Outcome