Fluctuations in cortical synchronization in pediatric traumatic brain injury.
Traumatic brain injury (TBI) is the leading cause of death and acquired disability in the pediatric population worldwide. We hypothesized that electroencephalography (EEG) synchrony and its temporal variability, analyzed during the acute phase following TBI, would be altered from that of normal children and as such would offer insights into TBI pathophysiology. Seventeen pediatric patients with mild to severe head injury admitted to a pediatric critical care unit were recruited along with 10 age- and gender-matched controls. Patients had two electroencephalographs performed 3 days apart. Outcome was measured at 1 year post-TBI utilizing the Pediatric Cerebral Performance Category score (PCPC). Maximal synchrony between EEG channels correlated to areas of primary injury as seen on computed tomography (CT) scan. The temporal variability of phase synchronization among EEG electrodes increased as patients recovered and emerged from coma (p < 0.001). This temporal variability correlated with outcome (Pearson coefficient of 0.74) better than the worst Glasgow Coma Scale score, length of coma, or extent of injury on CT scan. This represents a novel approach in the evaluation of TBI in children.
Nenadovic
Vera
V
Critical Care Medicine Program, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada.
Hutchison
James S
JS
Dominguez
Luis Garcia
LG
Otsubo
Hiroshi
H
Gray
Martin P
MP
Sharma
Rohit
R
Belkas
Jason
J
Perez Velazquez
Jose Luis
JL
D000200:Action Potentials; D000293:Adolescent; D000367:Age Factors; D001930:Brain Injuries / Q000175:diagnosis / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000254:growth & development / Q000293:injuries* / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D003128:Coma / Q000175:diagnosis / Q000503:physiopathology; D003344:Cortical Synchronization; D004569:Electroencephalography / Q000379:methods; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007223:Infant; D008297:Male; D009415:Nerve Net / Q000254:growth & development / Q000293:injuries / Q000503:physiopathology; D017063:Outcome Assessment, Health Care; D011237:Predictive Value of Tests; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors; D014057:Tomography, X-Ray Computed