title: The effectiveness of measuring for fragmented red cells using an automated hematology analyzer in patients with thrombotic microangiopathy.
abstract: Thrombotic microangiopathy (TMA) or thrombotic thrombocytopenic purpura (TTP) is a life-threatening syndrome characterized by increased number of fragmented red cells (FRCs) and thrombocytopenia. FRCs can be measured using the recently developed automated hematology analyzer XE-2100. The normal range for FRCs is 0% to 0.205%, as determined by the automated hematology analyzer XE-2100. The FRC count is significantly elevated in patients with TMA associated with liver transplantation, bone marrow transplantation, or TTP. In patients with TMA after liver transplantation, the FRC count is significantly higher than in those without TMA. In receiver operating characteristic analysis for the diagnosis of TMA, the area under the curve is 0.986, suggesting that FRC is a useful marker for the diagnosis of TMA. When the cutoff value of FRC for TMA is 1.2%, the sensitivity is 90% and the specificity is 96%, indicating that FRC is the most useful screening test for the diagnosis of TMA.
authors.affiliation: Central Laboratory, Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Abe
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
authors.forename: Eri
authors.initials: E
authors.lastname: Yamada
authors.forename: Maki
authors.initials: M
authors.lastname: Noda
authors.forename: Makoto
authors.initials: M
authors.lastname: Ikejiri
authors.forename: Junji
authors.initials: J
authors.lastname: Nishioka
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Masuya
authors.forename: Syuji
authors.initials: S
authors.lastname: Isaji
authors.forename: Masanobu
authors.initials: M
authors.lastname: Usui
authors.forename: Sinji
authors.initials: S
authors.lastname: Uemoto
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Katayama
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nobori
mesh_terms: D000328:Adult; D000368:Aged; D000743:Anemia, Hemolytic / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D001331:Automation; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D016022:Case-Control Studies; D002648:Child; D004906:Erythrocyte Count / Q000295:instrumentation*; D004912:Erythrocytes / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry / Q000295:instrumentation*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013997:Time Factors; D055815:Young Adult