title: Dopaminergic modulation of cortico-cortical functional connectivity in Parkinson's disease: an MEG study.
abstract: Recent studies have demonstrated increased resting-state cortico-cortical functional connectivity in untreated Parkinson's disease (PD). We set out to determine whether this connectivity can be modulated by dopamine replacement therapy (DRT) and explore the relationship of therapy-induced changes in connectivity with motor improvement in the relatively early stages of DRT in PD. Whole-head magnetoencephalography was performed in an eyes-closed resting-state condition in 37 patients with levodopa-treated PD (Hoehn and Yahr stages 1-3) both in a practically defined "OFF" and in the "ON" medication state. Data analysis involved calculation of three synchronisation likelihood (SL; a general measure of linear and non-linear temporal correlations between time series) measures which reflect functional coupling within and between ten major cortical areas in five frequency bands. The transition from the "OFF" to the "ON" state led to increases of SL in the 4-30 Hz range, most conspicuously with regard to local SL, in tandem with motor improvement. We found a negative correlation between the change in local beta SL and the reduction of parkinsonism after DRT. Patients presenting with relatively large motor responses (41% or better) actually showed decreases in local beta SL. The present study shows that the already elevated levels of resting-state cortico-cortical functional connectivity in the 4-30 Hz range in mild to moderate PD are on average increased even further by DRT. However, a strong motor response appears to be associated with decreases in local beta-band coupling, which may constitute a risk factor for the development of motor response fluctuations or dyskinesias.
authors.affiliation: Institute for Clinical and Experimental Neurosciences, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands. d.stoffers@vumc.nl
authors.forename: Diederick
authors.initials: D
authors.lastname: Stoffers
authors.forename: Johannes L W
authors.initials: JL
authors.lastname: Bosboom
authors.forename: Erik Ch
authors.initials: ECh
authors.lastname: Wolters
authors.forename: Cornelis J
authors.initials: CJ
authors.lastname: Stam
authors.forename: Henk W
authors.initials: HW
authors.lastname: Berendse
mesh_terms: D000368:Aged; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism*; D015259:Dopamine Agents / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000187:drug effects; D009415:Nerve Net / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D009434:Neural Pathways / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D015259:Dopamine Agents; D007980:Levodopa; D004298:Dopamine