title: Concise synthesis of dimemorfan (DF) starting from 3-hydroxymorphinan (3-HM).
abstract: Dimemorfan (DF) has been known to possess neuroprotective properties. While this promising compound deserves further biological evaluation, synthetic methods have not improved since Murakami group unveiled the synthetic efforts in 1972. Herein a succinct synthesis toward DF from commercially available 3-hydroxymorphinan (3-HM) is disclosed. Other morphinan analogs have been effectively prepared by adopting the similar methodology.
authors.affiliation: Small Molecule Group, Central Research Institute, Green Cross Corporation, Yongin, Korea.
authors.forename: Jong Yup
authors.initials: JY
authors.lastname: Kim
authors.forename: Hyoung-Chun
authors.initials: HC
authors.lastname: Kim
authors.forename: Jeongmin
authors.initials: J
authors.lastname: Kim
authors.forename: Jinhwa
authors.initials: J
authors.lastname: Lee
mesh_terms: D003915:Dextromethorphan / Q000031:analogs & derivatives* / Q000737:chemistry; D009019:Morphinans / Q000138:chemical synthesis*; D018696:Neuroprotective Agents / Q000138:chemical synthesis*
chemical_list: D009019:Morphinans; D018696:Neuroprotective Agents; C012621:dimemorfan; D003915:Dextromethorphan; C054116:norlevorphanol