Polymorphisms of the TPMT gene in the Czech healthy population and patients with inflammatory bowel disease.
Genetic variation in thiopurine S-methyltransferase (TPMT) is a major factors for wide variation in the metabolism and safety of thiopurine drugs. We investigated the frequency of functional gene polymorphisms in 396 patients with inflammatory bowel disease and 300 healthy subjects. Frequencies of functionally deficient alleles TPMT*2, TPMT*3A, TPMT*3B, and TPMT*3B in the patient group were 0.1%, 4.3%, 0.1%, and 0.4%, respectively, and were similar to those of healthy subjects in the Czech population. Our results provide necessary information for pharmacoeconomic studies in the Czech Republic.
Slanar
Ondrej
O
Clinical Pharmacology Unit, Department of Pharmacology, First Faculty of Medicine Charles University, General Teaching Hospital, Prague, Czech Republic. oslan@lf1.cuni.cz
Bortlík
Martin
M
Buzková
Helena
H
Donoval
Robert
R
Pechandová
Kristina
K
Sebesta
Ivan
I
Lukás
Milan
M
Perlík
Frantisek
F
D001379:Azathioprine / Q000627:therapeutic use; D016022:Case-Control Studies; D018153:Czech Republic; D005787:Gene Frequency; D005838:Genotype; D006262:Health; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics*; D008780:Methyltransferases / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
D008780:Methyltransferases; C022745:thiopurine methyltransferase; D001379:Azathioprine