[Role of heat-shock proteins of Hsp70 family in changes of narcotic activity of hyperbaric nitrogen during increasing hypoxic stimulus].
The spontaneous motor activity and pose reflexes of male adult rats (Wistar) were observed in the course of high pressure nitrogen compression up to 4,1 MPa. The experiments were carried out under normoxic and hypoxic conditions. Stabile rat motor cortex oxygen tension was recording during the nitrogen compression up to 7,1 MPa under normoxic condition. Sensitivity to nitrogen high pressure to be on the increase under hypoxic conditions. In its turn, resistibility to nitrogen high pressure to be on the decrease under hypoxic conditions (oxygen partial pressure from 0,012 to 0,004 MPa). Quantity of high dencity heat shock proteins (Hsp70) rats motor cortex neurons was 3,44 times higher after course of high pressure nitrogen compression up to 4,1 MPa. For hypoxic exposure (6% O2) the difference was less pronounced - 2,2 times. Data about rat motor cortex neurons Hsp70 concentration under high nitrogen pressure and low oxygen pressure may turn to be a clear base for explanation hypoxic influence on processes of nitrogen narcosis.
Vetosh
A N
AN
Kostkin
V B
VB
Alekseeva
O A
OA
Korzhevskiĭ
D E
DE
D000399:Air Pressure; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D007150:Immunohistochemistry; D007222:Inert Gas Narcosis / Q000378:metabolism*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009044:Motor Cortex / Q000187:drug effects / Q000378:metabolism*; D009294:Narcotics / Q000494:pharmacology*; D009584:Nitrogen / Q000494:pharmacology*; D010100:Oxygen / Q000494:pharmacology; D011187:Posture; D051381:Rats; D017208:Rats, Wistar
D018840:HSP70 Heat-Shock Proteins; D009294:Narcotics; D009584:Nitrogen; D010100:Oxygen