Partially hydrolyzed guar gum attenuates the severity of pouchitis in a rat model of ileal J pouch-anal anastomosis.
We aimed to evaluate the efficacy of treatment with partially hydrolyzed guar gum (PHGG) using a rat model of ileal pouch-anal anastomosis and pouchitis. In the J pouch groups, tissue myeloperoxidase activities were significantly higher than native myeloperoxidase activities (P = 0.020; P = 0.015; P = 0.004, respectively). A statistically significant difference in total histological score was detected in the J pouch + 5% dextran sulfate sodium (DSS) group, compared to the J pouch control and the J pouch + 5% DSS + PHGG groups (P < 0.01 and P < 0.01, respectively). There was a significant overgrowth of aerobes and anaerobes in the J pouch + 5% DSS group. This study demonstrated that rectal administration of PHGG attenuates the severity of pouchitis in a rat model. In conclusion, PHGG may be an additional therapeutic strategy for the treatment of pouchitis.
Atila
Koray
K
Department of Surgery, School of Medicine, Dokuz Eylul University, Izmir, 35340, Turkey. koray.atila@deu.edu.tr
Terzi
Cem
C
Canda
Aras Emre
AE
Akhisaroglu
Serpil Tanriverdi
ST
Avci
Hatice Sanli
HS
Sarioglu
Sulen
S
Oktay
Gulgun
G
Gulay
Zeynep
Z
D000714:Anastomosis, Surgical / Q000009:adverse effects; D000818:Animals; D039021:Colonic Pouches / Q000009:adverse effects* / Q000473:pathology; D003967:Diarrhea / Q000188:drug therapy / Q000209:etiology; D005243:Feces / Q000382:microbiology; D005685:Galactans / Q000494:pharmacology / Q000627:therapeutic use*; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000209:etiology; D008351:Mannans / Q000494:pharmacology / Q000627:therapeutic use*; D009195:Peroxidase / Q000378:metabolism; D053149:Plant Gums / Q000494:pharmacology / Q000627:therapeutic use*; D019449:Pouchitis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D012007:Rectum; D015431:Weight Loss / Q000187:drug effects
D005685:Galactans; D008351:Mannans; D053149:Plant Gums; C007894:guar gum; D009195:Peroxidase