Mitochondria in skeletal muscle: adaptable rheostats of apoptotic susceptibility.
Apoptosis is an essential process that plays a critical role in both tissue development and maintenance. Apoptosis has been shown to be involved in skeletal muscle atrophy resulting from chronic muscular disuse, sarcopenia, and mitochondrial myopathies. Exercise may attenuate some of the proapoptotic adaptations that occur during these conditions. This review will focus on the factors influencing mitochondrially mediated apoptosis in skeletal muscle.
Adhihetty
Peter J
PJ
Department of Neurology and Neuroscience, Cornell University, New York, New York, USA.
O'Leary
Michael F N
MF
Hood
David A
DA
D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D008931:Mitochondria, Muscle / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009133:Muscular Atrophy / Q000473:pathology