Interactive 3D hybrid PET/CT imaging in the identification of myocardial viability in patients after myocardial infarction: feasibility study and clinical implications.
OBJECTIVE
Clinical decision-making in coronary artery disease requires integrated information on myocardial viability and coronary arteries, and cross-modality registration could facilitate this process. The recent emergence of hybrid positron emission tomography (PET)/computed tomography (CT) allows acquisition of this information in one study session; however, clinically useful software capable of presenting three-dimensional (3D) fused images to assess the relationship between myocardium and coronary arteries is limited.


METHODS
Patients with prior myocardial infarction were examined using electrocardiographically gated 18F-fluorodeoxyglucose PET and 16-slice CT.


RESULTS
There were seven patients; mean age was 59 +/- 15 years and six were male. Using 3D reconstruction, coregistration and interactive display, the topographical relationship between myocardial viability and coronary arteries was clearly identified.


CONCLUSIONS
We present a protocol to acquire CT coronary angiography and PET data and to visualize 3D fused images with an interactive visualization interface. This image coregistration is potentially useful to facilitate the process of image interpretation and decision-making.
Wu
Yen-Wen
YW
Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Lee
Wen-Jeng
WJ
Wang
Tzung-Dau
TD
Lin
Wei-Te
WT
Yen
Ruoh-Fang
RF
Wu
I-Hui
IH
Tzen
Kai-Yuan
KY
Tseng
Wen-Yih I
WY
D000328:Adult; D000368:Aged; D017023:Coronary Angiography / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D019788:Fluorodeoxyglucose F18; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D049268:Positron-Emission Tomography / Q000379:methods*; D014022:Tissue Survival; D014057:Tomography, X-Ray Computed / Q000379:methods*
D019788:Fluorodeoxyglucose F18