title: CCL genes in multiple sclerosis and systemic lupus erythematosus.
abstract: This follow up study aims to refine the roles of previously suggested candidate genes (CC chemokine ligands or CCLs) in multiple sclerosis (MS), and to test these markers in another autoimmune disorder, systemic lupus erythematosus (SLE). After stringent correction for multiple testing, we reject the importance of previously suggested borderline associations with CCLs in MS. A new finding is the differential distribution of CCL8 marker alleles and a haplotype in extreme severity subgroups of MS. In SLE, this study reveals strong associations with a marker and a haplotype encompassing the CCL14 gene, which suggests that a lupus relevant variant may lie within or in the proximity of this haplotype.
authors.affiliation: VAMC Research, 800. Irving Avenue, Syracuse, NY 13210, United States.
authors.forename: Tamara
authors.initials: T
authors.lastname: Vyshkina
authors.forename: Andrew
authors.initials: A
authors.lastname: Sylvester
authors.forename: Saud
authors.initials: S
authors.lastname: Sadiq
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bonilla
authors.forename: Andras
authors.initials: A
authors.lastname: Perl
authors.forename: Bernadette
authors.initials: B
authors.lastname: Kalman
mesh_terms: D000328:Adult; D019742:Chemokines, CC / Q000145:classification / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D019742:Chemokines, CC