Cranberry juice constituents impair lymphoma growth and augment the generation of antilymphoma antibodies in syngeneic mice.
In addition to its nutritional value, cranberry juice has been effective in treating urinary tract infections. Various reports have also demonstrated its potential for inhibiting in vitro growth of transformed cell lines. Here we show that a fraction [nondialyzable material (NDM) of a molecular weight range 12,000-30,000 (NDM 12-30K)] derived from cranberry juice impairs in vitro growth and invasion through extracellular matrix of Rev-2-T-6 murine lymphoma cells. Furthermore, intraperitoneal injection of this fraction at nontoxic doses both inhibits the growth of Rev-2-T-6 tumors in vivo and enhances the generation of antilymphoma antibodies. These findings demonstrate the in vivo efficacy of cranberry components against malignant lymphoma in immune competent hosts.
Hochman
Nira
N
Department of Prosthodontics, Faculty of Dental Medicine, Hebrew University-Hadassah, Jerusalem, Israel. hochman@vms.huji.ac.il
Houri-Haddad
Yael
Y
Koblinski
Jennifer
J
Wahl
Larry
L
Roniger
Maayan
M
Bar-Sinai
Allan
A
Weiss
Ervin I
EI
Hochman
Jacob
J
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000951:Antigens, Neoplasm / Q000276:immunology; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D001628:Beverages / Q000032:analysis*; D015153:Blotting, Western; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D005638:Fruit / Q000737:chemistry*; D007114:Immunization; D007163:Immunosorbent Techniques; D008223:Lymphoma / Q000276:immunology* / Q000473:pathology*; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D029799:Vaccinium macrocarpon / Q000737:chemistry*
D000906:Antibodies; D000951:Antigens, Neoplasm; D000972:Antineoplastic Agents, Phytogenic