The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?
Till date, the pharmaceutical industry has failed to bring effective and safe disease modifying osteoarthritic drugs (DMOADs) to the millions of patients suffering from this serious and deliberating disease. We provide a review of recent data reported on the investigation of DMOADs in clinical trials, including compounds inhibiting matrix-metalloproteinases (MMPs), bisphosphonates, cytokine blockers, calcitonin, inhibitors of inducible nitric oxide synthase (iNOS), doxycycline, glucosamine, and diacereine. We discuss the challenges associated with the drug development process in general and with DMOADs in particular, and we advance the need for a new development paradigm for DMOADs. Two central elements in this paradigm are a stronger focus on the biology of the joint and the application of new and more sensitive biomarkers allowing redesign of clinical trials in osteoarthritis.
Qvist
Per
P
Nordic Bioscience A/S, Herlev Hovedgade 207, DK-2730 Herlev, Denmark. pq@nordicbioscience.com
Bay-Jensen
Anne-Christine
AC
Christiansen
Claus
C
Dam
Erik B
EB
Pastoureau
Philippe
P
Karsdal
Morten A
MA
D000880:Anthraquinones / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D002116:Calcitonin / Q000627:therapeutic use; D016207:Cytokines / Q000037:antagonists & inhibitors; D004164:Diphosphonates / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D005944:Glucosamine / Q000627:therapeutic use; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors; D010003:Osteoarthritis / Q000188:drug therapy* / Q000503:physiopathology
D000880:Anthraquinones; D018501:Antirheumatic Agents; D016207:Cytokines; D004164:Diphosphonates; D061965:Matrix Metalloproteinase Inhibitors; C025292:diacerein; D002116:Calcitonin; D052247:Nitric Oxide Synthase Type II; D005944:Glucosamine; D004318:Doxycycline