A lexicon for homeodomain-DNA recognition.
Decoding the cis-regulatory logic of eukaryotic genomes requires knowledge of the DNA-binding specificities of all transcription factors. New work (Berger et al., 2008; Noyes et al., 2008) provides individual specificities for nearly all Drosophila and mouse homeodomains, key DNA-binding domains in many transcription factors. The data underscore the complexity of determining target specificities in vivo.
Affolter
Markus
M
Growth and Development, Biozentrum der Universität Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland. markus.affolter@unibas.ch
Slattery
Matthew
M
Mann
Richard S
RS
D000818:Animals; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004331:Drosophila melanogaster; D018398:Homeodomain Proteins / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D011485:Protein Binding
D018398:Homeodomain Proteins; D004247:DNA