title: Synthesis and cytotoxicity of aurilide analogs.
abstract: The artificial analogs of aurilide (1), a potent cytotoxic cyclodepsipeptide of marine origin, were synthesized, and the structure-activity relationships were investigated.
authors.affiliation: Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama 223-8522, Japan.
authors.forename: Kiyotake
authors.initials: K
authors.lastname: Suenaga
authors.forename: Shuri
authors.initials: S
authors.lastname: Kajiwara
authors.forename: Satomi
authors.initials: S
authors.lastname: Kuribayashi
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Handa
authors.forename: Hideo
authors.initials: H
authors.lastname: Kigoshi
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D047630:Depsipeptides / Q000737:chemistry*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D010456:Peptides, Cyclic / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D047630:Depsipeptides; D010456:Peptides, Cyclic; C532913:aurilide