title: Probiotic Lactobacillus plantarum 299v does not counteract unfavorable phytohemagglutinin-induced changes in the rat intestinal microbiota.
abstract: Application of phytohemagglutinin (PHA) in weaning feed has been suggested to stimulate intestinal epithelium maturation. In this study, PHA strongly affected the fecal bacterial population structure of rats. Escherichia coli overgrowth was not prevented by probiotic mannose-adhering Lactobacillus plantarum 299v. Therefore, use of PHA in weaning feed deserves careful evaluation.
authors.affiliation: Department Health and Safety, NIZO food research, P.O. Box 20, 6710 BA Ede, The Netherlands.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Gross
authors.forename: Jessica
authors.initials: J
authors.lastname: Wildner
authors.forename: Arjan
authors.initials: A
authors.lastname: Schonewille
authors.forename: Jan L W
authors.initials: JL
authors.lastname: Rademaker
authors.forename: Roelof
authors.initials: R
authors.lastname: van der Meer
authors.forename: Johannes
authors.initials: J
authors.lastname: Snel
mesh_terms: D000821:Animal Feed / Q000382:microbiology; D000818:Animals; D000898:Antibiosis; D001422:Bacterial Adhesion; D015169:Colony Count, Microbial; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D003967:Diarrhea / Q000382:microbiology; D004926:Escherichia coli / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D005243:Feces / Q000382:microbiology; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000382:microbiology*; D048191:Lactiplantibacillus plantarum / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D010835:Phytohemagglutinins / Q000494:pharmacology*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D019936:Probiotics; D051381:Rats; D017208:Rats, Wistar; D014886:Weaning
chemical_list: D004269:DNA, Bacterial; D021903:DNA, Ribosomal Spacer; D010835:Phytohemagglutinins