[Clear and pale cells of the nipple epidermis: a critical study of their varieties].
The stratified squamous epithelium of the nipple-areola complex may contain pale cells including: Paget's disease cells (PDCs), Toker cells (TCs), and so-called clear cells (CCs). PDCs are atypical, commonly concentrated along the basal layer. They stain for EMA, CAM5.2, cytokeratin 7, and HER2/neu oncoprotein. TCs are bland cells with roundish and scant-chromatin nuclei. TCs are reactive for EMA, CAM5.2, and cytokeratin 7, but show negativity for HER2/ neu oncoprotein. The majority of cells that have been called epidermal CCs fit the features of pagetoid dyskeratosis, reactive for high molecular weight cytokeratin. Other CCs showing signet-ring morphology correspond to a fixation artefact.
Val Bernal
J Fernando
JF
Real Academia de Medicina de Cantabria.
D004817:Epidermis / Q000473:pathology*; D006801:Humans; D009558:Nipples / Q000473:pathology*