Central venous-to-arterial carbon dioxide difference: an additional target for goal-directed therapy in septic shock?
OBJECTIVE
To test the hypothesis that, in resuscitated septic shock patients, central venous-to-arterial carbon dioxide difference [P(cv-a)CO(2)] may serve as a global index of tissue perfusion when the central venous oxygen saturation (ScvO(2)) goal value has already been reached.


METHODS
Prospective observational study.


METHODS
A 22-bed intensive care unit (ICU).


METHODS
After early resuscitation in the emergency unit, 50 consecutive septic shock patients with ScvO(2) > 70% were included immediately after their admission into the ICU (T0). Patients were separated in Low P(cv-a)CO(2) group (Low gap; n = 26) and High P(cv-a)CO(2) group (High gap; n = 24) according to a threshold of 6 mmHg at T0.


METHODS
Measurements were performed every 6 h over 12 h (T0, T6, T12).


RESULTS
At T0, there was a significant difference between Low gap patients and High gap patients for cardiac index (CI) (4.3 +/- 1.6 vs. 2.7 +/- 0.8 l/min/m(2), P < 0.0001) but not for ScvO(2) values (78 +/- 5 vs. 75 +/- 5%, P = 0.07). From T0 to T12, the clearance of lactate was significantly larger for the Low gap group than for the High gap group (P < 0.05) as well as the decrease of SOFA score at T24 (P < 0.01). At T0, T6 and T12, CI and P(cv-a)CO(2) values were inversely correlated (P < 0.0001).


CONCLUSIONS
In ICU-resuscitated patients, targeting only ScvO(2) may not be sufficient to guide therapy. When the 70% ScvO(2) goal-value is reached, the presence of a P(cv-a)CO(2) larger than 6 mmHg might be a useful tool to identify patients who still remain inadequately resuscitated.
Vallée
Fabrice
F
Pôle d'Anesthésie et Réanimation, Unité de Réanimation Polyvalente de Purpan, GRCB 48, Université Paul Sabatier, CHU de Toulouse, France. vallee.f@chu-toulouse.fr
Vallet
Benoit
B
Mathe
Olivier
O
Parraguette
Jacqueline
J
Mari
Arnaud
A
Silva
Stein
S
Samii
Kamran
K
Fourcade
Olivier
O
Genestal
Michèle
M
D018806:APACHE; D000136:Acid-Base Equilibrium; D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007362:Intensive Care Units; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000097:blood* / Q000503:physiopathology* / Q000628:therapy
D002245:Carbon Dioxide; D019344:Lactic Acid