title: [Applications of metabonomics in clinical diagnosis].
abstract: Metabonomics, as a newly developed technique, is expected to be a powerful technique in clinical diagnosis. Metabonomics-based diagnosis involves the global metabolic analysis of body-fluids, determination of biomarkers by multivariate statistic analysis, and establishemen of mathematic models for clinical diagnosis with the aid of pattern recognition. This article reviews the adoption of various analytical and computational strategies, application of metabonomics in clinical diagnosis, and potential challenges and development trends.
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Zhong-Ying
authors.initials: ZY
authors.lastname: Lin
authors.forename: Shi-Kai
authors.initials: SK
authors.lastname: Yan
authors.forename: Wei-Xing
authors.initials: WX
authors.lastname: Dai
authors.forename: Yun
authors.initials: Y
authors.lastname: Yang
authors.forename: Hui-Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Chuan
authors.initials: C
authors.lastname: Zhang
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism; D019937:Diagnostic Techniques and Procedures; D006801:Humans; D055442:Metabolome; D055432:Metabolomics / Q000379:methods*; D008962:Models, Theoretical; D015999:Multivariate Analysis
chemical_list: D015415:Biomarkers