title: [Central nervous system involvement in Wegener's granulomatosis].
abstract: BACKGROUND
  Wegener's granulomatosis (WG) is a systemic necrotizing vasculitis associated with c-ANCA antibodies. The involvement of the central nervous system in WG is uncommon and usually caused by in situ vasculitis, intracranial granuloma formation or contiguous invasion from extracranial sites.
  
  
  METHODS
  Here, we report on a tumour-like expansion of a severe nasosinusal WG into the brain, which was confirmed by brain biopsy examination.
  
  
  CONCLUSIONS
  The positivity of positron emission tomography in our observation supports the potential role of such functional imaging in the staging, as well as in the follow-up of WG.
authors.affiliation: Service de médecine interne générale, cliniques universitaires de Saint-Luc, université catholique Louvain, avenue Hippocrate, 1200 Bruxelles, Belgique.
authors.forename: F
authors.initials: F
authors.lastname: Jouret
authors.forename: S
authors.initials: S
authors.lastname: Noirhomme
authors.forename: C
authors.initials: C
authors.lastname: Grandin
authors.forename: M
authors.initials: M
authors.lastname: Lonneux
authors.forename: C
authors.initials: C
authors.lastname: Godfraind
authors.forename: M
authors.initials: M
authors.lastname: Lambert
authors.forename: C
authors.initials: C
authors.lastname: Lefebvre
mesh_terms: D001706:Biopsy; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000473:pathology; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed