title: Heteroatom-containing antibacterial phenolic metabolites from a terrestrial Ampelomyces fungus.
abstract: Two new sulfur-containing phenolic compounds, 7-hydroxy-5-hydroxymethyl-2H-benzo[1,4]thiazin-3-one (1) and 2,5-dihydroxy-3-methanesulfinylbenzyl alcohol (2), along with two known compounds, 3-chloro-2,5-dihydroxybenzyl alcohol (3) and 2-hydroxy-6-methylbenzoic acid (4), were isolated from the mycelial solid culture of a soil-derived Ampelomyces fungus by antibacterial assay-guided fractionation. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1-3 showed structure and microbial dependent antibacterial activities.
authors.affiliation: South China Botanical Garden, Chinese Academy of Sciences, Tianhe District, Guangzhou, People's Republic of China.
authors.forename: Huiye
authors.initials: H
authors.lastname: Zhang
authors.forename: Haihui
authors.initials: H
authors.lastname: Xie
authors.forename: Samuel X
authors.initials: SX
authors.lastname: Qiu
authors.forename: Jinghua
authors.initials: J
authors.lastname: Xue
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification*; D001419:Bacteria / Q000187:drug effects; D001688:Biological Products; D005658:Fungi / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products; D010636:Phenols