title: Impact of exogenous sequences on the characteristics of an epidemic type 2 recombinant vaccine-derived poliovirus.
abstract: Pathogenic circulating vaccine-derived polioviruses (cVDPVs) have become a major obstacle to the successful completion of the global polio eradication program. Most cVDPVs are recombinant between the oral poliovirus vaccine (OPV) and human enterovirus species C (HEV-C). To study the role of HEV-C sequences in the phenotype of cVDPVs, we generated a series of recombinants between a Madagascar cVDPV isolate and its parental OPV type 2 strain. Results indicated that the HEV-C sequences present in this cVDPV contribute to its characteristics, including pathogenicity, suggesting that interspecific recombination contributes to the phenotypic biodiversity of polioviruses and may favor the emergence of cVDPVs.
authors.affiliation: Unité de Biologie des Virus Entériques, Institut Pasteur, Paris, France.
authors.forename: Franck B
authors.initials: FB
authors.lastname: Riquet
authors.forename: Claire
authors.initials: C
authors.lastname: Blanchard
authors.forename: Sophie
authors.initials: S
authors.lastname: Jegouic
authors.forename: Jean
authors.initials: J
authors.lastname: Balanant
authors.forename: Sophie
authors.initials: S
authors.lastname: Guillot
authors.forename: Marie-Anne
authors.initials: MA
authors.lastname: Vibet
authors.forename: Mala
authors.initials: M
authors.lastname: Rakoto-Andrianarivelo
authors.forename: Francis
authors.initials: F
authors.lastname: Delpeyroux
mesh_terms: D001483:Base Sequence; D045744:Cell Line, Tumor; D018076:DNA, Complementary; D004196:Disease Outbreaks; D030015:Enterovirus C, Human / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D008969:Molecular Sequence Data; D011051:Poliomyelitis / Q000453:epidemiology* / Q000821:virology; D017955:Poliovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage*; D011995:Recombination, Genetic; D014614:Vaccines, Synthetic / Q000737:chemistry* / Q000235:genetics; D014779:Virus Replication
chemical_list: D018076:DNA, Complementary; D011055:Poliovirus Vaccine, Oral; D014614:Vaccines, Synthetic