title: Association of apolipoprotein E genotype and cerebrovascular disease risk factors in a Turkish population.
abstract: The purpose of the present study was to investigate the predictive role of apolipoprotein E genotypes for stroke-related risk factors in the Turkish population. Among 100 stroke patients and 30 healthy subjects included in the study, most frequent Apo E genotype was epsilon3/3, compatible with polymorphic distribution of Asian population. VLDL and triglyceride levels in epsilon2/4(+) subjects were higher than in epsilon2/4(-) patients. HDL and homocysteine levels were higher in epsilon4/4 (+) subjects than in epsilon4/4 (-) stroke patients. These results suggest that ApoE polymorphism in this population was not associated with any other demographic or clinical variables except for lipid profiles and homocysteine levels.
authors.affiliation: Department of Neurology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors.forename: Nebahat
authors.initials: N
authors.lastname: Tasdemir
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Tamam
authors.forename: Recep
authors.initials: R
authors.lastname: Toprak
authors.forename: Banu
authors.initials: B
authors.lastname: Tamam
authors.forename: M Serhan
authors.initials: MS
authors.lastname: Tasdemir
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000150:complications; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications / Q000235:genetics; D008079:Lipoproteins, VLDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D020033:Protein Isoforms / Q000235:genetics; D012016:Reference Values; D012307:Risk Factors; D012737:Sex Factors; D018709:Statistics, Nonparametric; D020521:Stroke / Q000097:blood / Q000150:complications / Q000235:genetics*; D014280:Triglycerides / Q000097:blood*
chemical_list: D001057:Apolipoproteins E; D008079:Lipoproteins, VLDL; D020033:Protein Isoforms; D014280:Triglycerides