NDRG2: a Myc-repressed gene involved in cancer and cell stress.
As a master switch for cell proliferation and differentiation, Myc exerts its biological functions mainly through transcriptional regulation of its target genes, which are involved in cells?interaction and communication with their external environment. The N-myc downstream-regulated gene (NDRG) family is composed of NDRG1, NDRG2, NDRG3 and NDRG4, which are important in cell proliferation and differentiation. This review summarizes the recent studies on the structure, tissue distribution and functions of NDRG2 that try to show its significance in studying cancer and its therapeutic potential.
Yao
Libo
L
The Institute of Molecular Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an 710032, China. bioyao@fmmu.edu.cn
Zhang
Jian
J
Liu
Xuewu
X
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D018384:Oxidative Stress; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
C466228:NDRG2 protein, human; D025521:Tumor Suppressor Proteins