Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions.
Junctophilins (JPs) contribute to the formation of junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum, and provide a structural platform for channel communication during excitation-contraction coupling in muscle cells. In the brain, two neuronal JP subtypes are widely expressed in neurons. Recent studies have defined the essential role of neural JPs in the communication between cell-surface and intracellular channels, which modulates the excitability and synaptic plasticity of neurons in the cerebellum and hippocampus.
Kakizawa
Sho
S
Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Moriguchi
Shigeki
S
Ikeda
Atsushi
A
Iino
Masamitsu
M
Takeshima
Hiroshi
H
D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D002531:Cerebellum / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D007859:Learning Disabilities / Q000235:genetics; D008322:Mammals; D008565:Membrane Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D008569:Memory Disorders / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D012519:Sarcoplasmic Reticulum / Q000502:physiology
C481843:Jph4 protein, mouse; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C412507:junctophilin