Adipokines and ghrelin in gastric cancer cachexia.
OBJECTIVE
To investigate the roles of the adipocytokines, ghrelin and leptin in gastric cancer cachexia.


METHODS
Resistin, ghrelin, leptin, adiponectin, insulin and insulin-like growth factor (IGF-I), were measured in 30 healthy subjects, and 60 gastric cancer patients of which 30 suffered from cancer-induced cachexia and 30 served as a control group. The relationships between hormones, body mass index (BMI) loss ratio, age, gender, and Glasgow Prognostic Score (GPS) were investigated.


RESULTS
Cachexia patients had higher tumor stage and GPS when compared with non-cachexia patients (P < 0.05). Ghrelin, resistin, leptin, adiponectin and IGF-I, showed a significant correlation with BMI loss ratio and GPS (P < 0.05). A strong correlation was seen between GPS and BMI loss (R = -0.570, P < 0.0001). Multivariate analysis indicated that BMI loss was significantly independent as a predictor of ghrelin, resistin, leptin and IGF-I (P < 0.05). Existence of an important significant relationship between resistin and insulin resistance was also noted.


CONCLUSIONS
These results showed that serum ghrelin, leptin, adiponectin, and IGF-I play important roles in cachexia-related gastric cancers. No relationship was found between resistin and cancer cachexia. Also, because of the correlation between these parameters and GPS, these parameters might be used as a predictor factor.
Kerem
Mustafa
M
Department of General Surgery, Faculty of Medicine, Gazi University, Besevler 06510, Ankara, Turkey. keremm1@yahoo.com.
Ferahkose
Zafer
Z
Yilmaz
Utku Tonguc
UT
Pasaoglu
Hatice
H
Ofluoglu
Ebru
E
Bedirli
Abdulkadir
A
Salman
Bulent
B
Sahin
Tevfik Tolga
TT
Akin
Murat
M
D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002100:Cachexia / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011228:Prealbumin / Q000378:metabolism; D011446:Prospective Studies; D052243:Resistin / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism; D012720:Severity of Illness Index; D013274:Stomach Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D013997:Time Factors
C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D001786:Blood Glucose; D054439:Ghrelin; D007328:Insulin; D020738:Leptin; D011228:Prealbumin; C499624:RETN protein, human; D052243:Resistin; D012709:Serum Albumin; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein