Discrimination learning in Rora(sg) and Grid2(ho) mutant mice.
Rora(sg) mutants with mild cerebellar granule cell degeneration were compared to Grid2(ho) mutants with more severe granule cell degeneration as well as Purkinle cell atrophy for left-right and dark-light discrimination learning tasks in a water-filled T-maze. The acquisition rate of both cerebellar mutants was slowed down during light-dark but not left-right discrimination learning. However, the mutants were impaired in reversal training in both tasks. In contrast, neither mutant differed from controls in passive avoidance learning. These results indicate that mice with cerebellar damage are affected in some instrumental learning tasks and have perseverative tendencies.
Lalonde
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Centre Hospitalier de l'Université de Montréal/St-Luc, Unité de Recherche en Sciences Neurologiques, 1058 St-Denis St., Montréal, Que. H2X3J4, Canada. robert.lalonde@umontreal.ca
Strazielle
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D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000483:Alleles; D000818:Animals; D001284:Atrophy; D001362:Avoidance Learning / Q000502:physiology; D002525:Cerebellar Cortex / Q000473:pathology; D004193:Discrimination Learning / Q000502:physiology*; D004924:Escape Reaction / Q000502:physiology*; D005239:Fear / Q000502:physiology; D018782:Maze Learning / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008818:Mice, Neurologic Mutants; D009042:Motivation; D009474:Neurons / Q000473:pathology; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1; D009949:Orientation / Q000502:physiology*; D011689:Purkinje Cells / Q000473:pathology; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D012193:Reversal Learning / Q000502:physiology; D013132:Spinocerebellar Degenerations / Q000235:genetics* / Q000473:pathology*; D015534:Trans-Activators / Q000235:genetics*
D048868:Adaptor Proteins, Signal Transducing; C498726:Mona protein, mouse; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1; D018160:Receptors, Cytoplasmic and Nuclear; C539739:Rora protein, mouse; D015534:Trans-Activators