title: Assessment of genetic risk factors for thoracic aortic aneurysm in hypertensive patients.
abstract: BACKGROUND
  Conventional risk factors for thoracic aortic aneurysm including dissection (TAA) are thought to include age, arteriosclerosis, and hypertension. In addition, evidence suggests that genetic factors play a role in the development of this condition. The purpose of the present study was to identify genetic variants that confer susceptibility to TAA in hypertensive subjects.
  
  
  METHODS
  Study subjects comprised 1,351 hypertensive individuals: 88 patients with TAA and 1,263 subjects without this condition. The genotypes for 142 polymorphisms of 119 candidate genes were determined by a method that combines the PCR and sequence-specific oligonucleotide probes with suspension array technology.
  
  
  RESULTS
  Evaluation of genotype distributions by the chi2-test and subsequent multivariable logistic regression analysis with adjustment for covariates revealed that the 3949T-->G (3' untranslated region) polymorphism of the thrombospondin-2 gene (THBS2; odds ratio, 4.6), the -110A-->C polymorphism of the heat shock 70-kDa protein 8 gene (HSPA8; odds ratio, 0.4), the C-->T (Pro198Leu) polymorphism of the glutathione peroxidase 1 gene (GPX1; odds ratio, 0.3), the -6G-->A polymorphism of the angiotensinogen gene (AGT; odds ratio, 0.3), and the -850C-->T polymorphism of the tumor necrosis factor gene (TNF; odds ratio, 0.5) were significantly (P < 0.05) associated with TAA.
  
  
  CONCLUSIONS
  The variant allele of THBS2 is a risk factor for TAA in hypertensive patients, whereas the variant alleles of HSPA8, GPX1, AGT, and TNF are protective against this condition. Determination of genotypes for these polymorphisms may prove informative for assessment of the genetic risk for TAA.
authors.affiliation: Department of Cardiovascular Medicine, Gifu Prefectural Government Tajimi Hospital, Tajimi, Japan. gogok@nifty.com
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kato
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Oguri
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kato
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hibino
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yajima
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yoshida
authors.forename: Norifumi
authors.initials: N
authors.lastname: Metoki
authors.forename: Hidemi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Kei
authors.initials: K
authors.lastname: Satoh
authors.forename: Sachiro
authors.initials: S
authors.lastname: Watanabe
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yokoi
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D000368:Aged; D000784:Aortic Dissection / Q000235:genetics; D017545:Aortic Aneurysm, Thoracic / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D015345:Oligonucleotide Probes