First detection of the OXA-40 carbapenemase in P. aeruginosa isolates, located on a plasmid also found in A. baumannii.
The aim of this work was to carry out the molecular investigation of the OXA-40 carbapenemase detected in two isolates of Pseudomonas aeruginosa resistant to imipenem. The sequence showed 100% of homology with the gene previously described in Acinetobacter baumannii. Hybridization experiments located the gene on a plasmid also found in the OXA-40 control strain of A. baumannii.
Sevillano
E
E
Departamento Inmunología, Facultad de Medicina y Odontología, Universidad del País Vasco, Aptdo. 699, 48080 Bilbao, Spain. elena.sevillano@ehu.es
Gallego
L
L
García-Lobo
J M
JM
D040981:Acinetobacter baumannii / Q000201:enzymology* / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D015780:Carbapenems / Q000494:pharmacology; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D010957:Plasmids / Q000235:genetics; D011550:Pseudomonas aeruginosa / Q000201:enzymology* / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
D001426:Bacterial Proteins; D015780:Carbapenems; D004269:DNA, Bacterial; D001618:beta-Lactamases; C063912:carbapenemase