title: Towards environmental systems biology of Shewanella.
abstract: Bacteria of the genus Shewanella are known for their versatile electron-accepting capacities, which allow them to couple the decomposition of organic matter to the reduction of the various terminal electron acceptors that they encounter in their stratified environments. Owing to their diverse metabolic capabilities, shewanellae are important for carbon cycling and have considerable potential for the remediation of contaminated environments and use in microbial fuel cells. Systems-level analysis of the model species Shewanella oneidensis MR-1 and other members of this genus has provided new insights into the signal-transduction proteins, regulators, and metabolic and respiratory subsystems that govern the remarkable versatility of the shewanellae.
authors.affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA. jim.fredrickson@pnl.gov; tiedjej@msu.edu
authors.forename: James K
authors.initials: JK
authors.lastname: Fredrickson
authors.forename: Margaret F
authors.initials: MF
authors.lastname: Romine
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Beliaev
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Auchtung
authors.forename: Michael E
authors.initials: ME
authors.lastname: Driscoll
authors.forename: Timothy S
authors.initials: TS
authors.lastname: Gardner
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Nealson
authors.forename: Andrei L
authors.initials: AL
authors.lastname: Osterman
authors.forename: Grigoriy
authors.initials: G
authors.lastname: Pinchuk
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Reed
authors.forename: Dmitry A
authors.initials: DA
authors.lastname: Rodionov
authors.forename: Jorge L M
authors.initials: JL
authors.lastname: Rodrigues
authors.forename: Daad A
authors.initials: DA
authors.lastname: Saffarini
authors.forename: Margrethe H
authors.initials: MH
authors.lastname: Serres
authors.forename: Alfred M
authors.initials: AM
authors.lastname: Spormann
authors.forename: Igor B
authors.initials: IB
authors.lastname: Zhulin
authors.forename: James M
authors.initials: JM
authors.lastname: Tiedje
mesh_terms: D001673:Biodegradation, Environmental; D001674:Bioelectric Energy Sources; D002244:Carbon / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D005947:Glucose / Q000378:metabolism; D010100:Oxygen / Q000494:pharmacology*; D020592:Shewanella / Q000378:metabolism*; D049490:Systems Biology
chemical_list: D002244:Carbon; D005947:Glucose; D010100:Oxygen