The inhibition of Candida species by selected essential oils and their synergism with amphotericin B.
In this work we highlight a possible synergistic anti-Candida effect between Melaleuca alternifolia, Origanum vulgare and Pelargonium graveolens essential oils and the antifungal compound Amphotericin B. The antifungal activity was assessed using the agar dilution method in eleven Candida strains. The results obtained indicate the occurrence of a synergistic interaction between the essential oils under study and Amphotericin B. P. graveolens essential oil appeared to be the most effective, inhibiting all the Candida species evaluated by this study.
Rosato
Antonio
A
Department of Pharmaceutical Chemistry, Section of Microbiology, University of Bari, Via E. Orabona n. 4, 70125 Bari, Italy. arosato@farmchim.uniba.it
Vitali
Cesare
C
Gallo
Daniela
D
Balenzano
Luca
L
Mallamaci
Rosanna
R
D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D002175:Candida / Q000187:drug effects*; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D031316:Pelargonium / Q000737:chemistry*; D020947:Tea Tree Oil / Q000737:chemistry / Q000494:pharmacology*
D009822:Oils, Volatile; C029292:origanum oil; D020947:Tea Tree Oil; D000666:Amphotericin B