title: Effect of polyethylene glycol on preparation of rifampicin-loaded PLGA microspheres with membrane emulsification technique.
abstract: Monodisperse poly(lactide-co-glycolide) (PLGA) microspheres containing rifampicin (RFP), anti-tubercle drug, as hydrophobic model drug were prepared by solvent evaporation method with a membrane emulsification technique using Shirasu Porous Glass (SPG) membranes. Five kinds of rifampicin-loaded PLGA (RFP/PLGA) microspheres with different sizes were prepared by changing pore size of the membranes. Effect of polyethylene glycol (PEG) added to polyvinyl alcohol (PVA) solution (continuous phase) upon the monodispersity of microspheres was studied. PEG was used as a stabilizer for microspheres dispersing in PVA solution. The most suitable molecular weight of PEG as a stabilizer was 20,000. RFP/PLGA microspheres prepared with PEG20000 were apparently more uniform than those prepared without PEG. The yield of RFP/PLGA microspheres was 100%. The initial burst observed in the release of RFP from RFP/PLGA microspheres was suppressed by the addition of PEG.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. fuminoito@spice.ocn.ne.jp
authors.forename: Fuminori
authors.initials: F
authors.lastname: Ito
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujimori
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Honnami
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Kawakami
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kanamura
authors.forename: Kimiko
authors.initials: K
authors.lastname: Makino
mesh_terms: D000904:Antibiotics, Antitubercular / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D004655:Emulsions; D019344:Lactic Acid / Q000737:chemistry*; D008567:Membranes, Artificial; D008863:Microspheres; D011092:Polyethylene Glycols / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012293:Rifampin / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000904:Antibiotics, Antitubercular; D004337:Drug Carriers; D004655:Emulsions; D008567:Membranes, Artificial; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols; D011142:Polyvinyl Alcohol; D012293:Rifampin