title: Asian specific low mutation frequencies of the M287T polymorphism in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene.
abstract: Groundwater pollution by arsenic is a serious worldwide problem, especially in Asian countries. Inter-individual variation in arsenic metabolism has been reported and recent studies demonstrate that 287T allele in human arsenic (+3 oxidation state) methyltransferase (AS3MT) increase the percentage of monomethylated arsenic in urine. The objectives of the present study was to evaluate the ethnic difference in M287T (T/C) polymorphism in AS3MT among Japanese (n=1074), Koreans (n=435), Chinese (n=154), Mongolians (n=246), Uygurs (n=56), Tibetans (n=180), Tamangs (n=53), Tamils (n=58), Sinhalese (n=54), Turks (n=243), Ovambos (n=185), Ghanaians (n=121), Xhosas (n=101), and other four populations from previous studies. Of 17 populations, Xhosas had the highest 287T frequency (0.233). Other African and Caucasian populations had similar287T frequencies above 0.100 with the exception of the Ghanaians (0.071). On the other hand, the Asian populations had relatively lower 287T allele frequencies ranging from 0.000 to 0.041 than the Africans and Caucasians. Our findings indicate that genetic susceptibility to arsenic toxicity in Asian is different from Africans and Caucasians.
authors.affiliation: Department of Legal Medicine, Shimane University School of Medicine, 89-1 Enya, Izumo, Shimane 693-8501, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Fujihara
authors.forename: Mikiko
authors.initials: M
authors.lastname: Soejima
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Koda
authors.forename: Takashi
authors.initials: T
authors.lastname: Kunito
authors.forename: Haruo
authors.initials: H
authors.lastname: Takeshita
mesh_terms: D001151:Arsenic / Q000633:toxicity; D020261:Arsenic Poisoning / Q000208:ethnology* / Q000235:genetics*; D044466:Asian People; D005787:Gene Frequency; D006801:Humans; D008780:Methyltransferases / Q000235:genetics*; D009154:Mutation; D011110:Polymorphism, Genetic; D044465:White People
chemical_list: D008780:Methyltransferases; C505756:AS3MT protein, human; D001151:Arsenic