title: [Case of bilateral pneumothorax observed during the administration of gefitinib for lung adenocarcinoma with multiple pulmonary metastases].
abstract: A 61-year-old woman who had never smoked was given a diagnosis of adenocarcinoma of the lung with multiple pulmonary metastases. Systemic chemotherapy consisting of carboplatin and paclitaxel was not effective, thereafter daily oral administration of gefitinib was initiated. Six days later, bilateral pneumothorax was found. The extent of the pneumothorax was slight and she recovered without drainage within about one month although treatment of gefitinib was restarted. Gefitinib was effective for lung cancer in this case. Bilateral pneumothorax is a rare complication of chemotherapy for lung cancer. Only 3 such cases under treatment with gefitinib were reported in Japan.
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital.
authors.forename: Megumi
authors.initials: M
authors.lastname: Fukai
authors.forename: Masahide
authors.initials: M
authors.lastname: Mori
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Namba
authors.forename: Kenji
authors.initials: K
authors.lastname: Fushitani
authors.forename: Yukie
authors.initials: Y
authors.lastname: Nakazawa
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Yano
authors.forename: Manabu
authors.initials: M
authors.lastname: Niinaka
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kimura
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Naka
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Okada
authors.forename: Masaru
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Soichiro
authors.initials: S
authors.lastname: Yokota
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects; D011030:Pneumothorax / Q000139:chemically induced*; D011799:Quinazolines / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D011799:Quinazolines; D016190:Carboplatin; D017239:Paclitaxel; D000077156:Gefitinib