title: A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands.
abstract: A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands is reported.
authors.affiliation: Chemical & Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, USA. liuk1@wyeth.com
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Liu
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Lo
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Comery
authors.forename: Guo Ming
authors.initials: GM
authors.lastname: Zhang
authors.forename: Jean Y
authors.initials: JY
authors.lastname: Zhang
authors.forename: Dianne M
authors.initials: DM
authors.lastname: Kowal
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Smith
authors.forename: Li
authors.initials: L
authors.lastname: Di
authors.forename: Edward H
authors.initials: EH
authors.lastname: Kerns
authors.forename: Lee E
authors.initials: LE
authors.lastname: Schechter
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Robichaud
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D007700:Kinetics; D008024:Ligands; D008956:Models, Chemical; D015394:Molecular Structure; D011485:Protein Binding / Q000187:drug effects; D011985:Receptors, Serotonin / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014363:Tryptamines / Q000737:chemistry
chemical_list: D007211:Indoles; D008024:Ligands; D011985:Receptors, Serotonin; D014363:Tryptamines; C097216:serotonin 6 receptor