title: Embryogenesis of the heart muscle.
abstract: This article concerns the development of myocardial architecture--crucial for contractile performance of the heart and its conduction system, essential for generation and coordinated spread of electrical activity. Topics discussed include molecular determination of cardiac phenotype (contractile and conducting), remodeling of ventricular wall architecture and its blood supply, and relation of trabecular compaction to noncompaction cardiomyopathy. Illustrated are the structure and function of the tubular heart, time course of trabecular compaction, and development of multilayered spiral systems of the compact layer.
authors.affiliation: Institute of Animal Physiology and Genetics, Prague, Czech Republic. sedmera@iapg.cas.cz
authors.forename: David
authors.initials: D
authors.lastname: Sedmera
authors.forename: Tim
authors.initials: T
authors.lastname: McQuinn
mesh_terms: D047108:Embryonic Development / Q000502:physiology*; D006321:Heart / Q000196:embryology* / Q000254:growth & development / Q000502:physiology*; D006329:Heart Conduction System / Q000502:physiology; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology; D009206:Myocardium; D032383:Myocytes, Cardiac / Q000502:physiology*; D016276:Ventricular Function; D020257:Ventricular Remodeling / Q000502:physiology