Host-microbe interactions: innate pattern recognition of fungal pathogens.
The recognition of fungi is mediated by germline pattern recognition receptors (PRRs) such as Toll-like receptors and lectin receptors that interact with conserved structures of the microorganisms, the pathogen-associated molecular patterns (PAMPs). Subsequently, PRRs activate intracellular signals that collaborate for the efficient activation of the host defense. The specificity of these responses is achieved through the activation of a particular mosaic of PRRs, that is determined by the available fungal PAMPs and the innate immune cells involved. This will determine a divergence of the final type of reaction, and in this way the innate host defense has the capability to deliver tailored responses to each pathogen.
van de Veerdonk
Frank L
FL
Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Kullberg
Bart Jan
BJ
van der Meer
Jos W M
JW
Gow
Neil A R
NA
Netea
Mihai G
MG
D000818:Animals; D005658:Fungi / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate