title: Compensatory hyperactivations as markers of latent working memory dysfunctions in patients with obsessive-compulsive disorder: an fMRI study.
abstract: OBJECTIVE
  Behavioural studies have implicated working memory (WM) deficits in obsessive-compulsive disorder (OCD). However, findings are inconsistent, which could be explained by compensation strategies used by a subgroup of OCD patients. To test this hypothesis, we examined patients without a behavioural deficit in WM during performance of different WM tasks using functional magnetic resonance imaging (fMRI).
  
  
  METHODS
  We scaned 11 patients and 11 matched control subjects while they performed 3 verbal and spatial item-recognition tasks.
  
  
  RESULTS
  Patients and healthy subjects engaged the same set of brain regions. However, in direct comparison, the patients exhibited significantly greater task-related activation in several frontal and parietal brain areas known to underlie WM.
  
  
  CONCLUSIONS
  Patients without manifest WM deficits exhibit increased activation in frontal and parietal brain areas relative to healthy subjects during WM task performance. These hyperactivations may permit them to compensate for reduced efficiency of their WM systems and may thus serve as markers of latent WM dysfunctions.
authors.affiliation: Systems Neuroscience Unit, Department of Psychiatry and Psychotherapy, Georg-August-University, Göttingen, Germany. Ilona.Henseler@medizin.uni-goettingen.de
authors.forename: Ilona
authors.initials: I
authors.lastname: Henseler
authors.forename: Oliver
authors.initials: O
authors.lastname: Gruber
authors.forename: Susanne
authors.initials: S
authors.lastname: Kraft
authors.forename: Christoph
authors.initials: C
authors.lastname: Krick
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Reith
authors.forename: Peter
authors.initials: P
authors.lastname: Falkai
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D003710:Demography; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D008570:Memory, Short-Term / Q000502:physiology*; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D010296:Parietal Lobe / Q000378:metabolism* / Q000503:physiopathology*; D021641:Recognition, Psychology; D012720:Severity of Illness Index; D013028:Space Perception / Q000502:physiology; D011795:Surveys and Questionnaires; D014705:Verbal Behavior