title: Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
abstract: A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others have shown that resveratrol mimics effects of DR in lower organisms. In mice, we find that resveratrol induces gene expression patterns in multiple tissues that parallel those induced by DR and every-other-day feeding. Moreover, resveratrol-fed elderly mice show a marked reduction in signs of aging, including reduced albuminuria, decreased inflammation, and apoptosis in the vascular endothelium, increased aortic elasticity, greater motor coordination, reduced cataract formation, and preserved bone mineral density. However, mice fed a standard diet did not live longer when treated with resveratrol beginning at 12 months of age. Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.
authors.affiliation: Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Pearson
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Baur
authors.forename: Kaitlyn N
authors.initials: KN
authors.lastname: Lewis
authors.forename: Leonid
authors.initials: L
authors.lastname: Peshkin
authors.forename: Nathan L
authors.initials: NL
authors.lastname: Price
authors.forename: Nazar
authors.initials: N
authors.lastname: Labinskyy
authors.forename: William R
authors.initials: WR
authors.lastname: Swindell
authors.forename: Davida
authors.initials: D
authors.lastname: Kamara
authors.forename: Robin K
authors.initials: RK
authors.lastname: Minor
authors.forename: Evelyn
authors.initials: E
authors.lastname: Perez
authors.forename: Hamish A
authors.initials: HA
authors.lastname: Jamieson
authors.forename: Yongqing
authors.initials: Y
authors.lastname: Zhang
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Dunn
authors.forename: Kumar
authors.initials: K
authors.lastname: Sharma
authors.forename: Nancy
authors.initials: N
authors.lastname: Pleshko
authors.forename: Laura A
authors.initials: LA
authors.lastname: Woollett
authors.forename: Anna
authors.initials: A
authors.lastname: Csiszar
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ikeno
authors.forename: David
authors.initials: D
authors.lastname: Le Couteur
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Elliott
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Becker
authors.forename: Placido
authors.initials: P
authors.lastname: Navas
authors.forename: Donald K
authors.initials: DK
authors.lastname: Ingram
authors.forename: Norman S
authors.initials: NS
authors.lastname: Wolf
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Ungvari
authors.forename: David A
authors.initials: DA
authors.lastname: Sinclair
authors.forename: Rafael
authors.initials: R
authors.lastname: de Cabo
mesh_terms: D000367:Age Factors; D000375:Aging / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D031204:Caloric Restriction; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology; D002149:Energy Intake / Q000235:genetics*; D005508:Food Deprivation / Q000502:physiology; D005526:Food, Formulated; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D007249:Inflammation / Q000188:drug therapy / Q000517:prevention & control; D008136:Longevity / Q000187:drug effects* / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010024:Osteoporosis / Q000188:drug therapy / Q000517:prevention & control; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use; D014158:Transcription, Genetic / Q000187:drug effects* / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol