A genome-wide linkage scan identifies multiple chromosomal regions influencing serum lipid levels in the population on the Samoan islands.
Abnormal lipid levels are important risk factors for cardiovascular diseases. We conducted genome-wide variance component linkage analyses to search for loci influencing total cholesterol (TC), LDL, HDL and triglyceride in families residing in American Samoa and Samoa as well as in a combined sample from the two polities. We adjusted the traits for a number of environmental covariates, such as smoking, alcohol consumption, physical activity, and material lifestyle. We found suggestive univariate linkage with log of the odds (LOD) scores > 3 for LDL on 6p21-p12 (LOD 3.13) in Samoa and on 12q21-q23 (LOD 3.07) in American Samoa. Furthermore, in American Samoa on 12q21, we detected genome-wide linkage (LOD(eq) 3.38) to the bivariate trait TC-LDL. Telomeric of this region, on 12q24, we found suggestive bivariate linkage to TC-HDL (LOD(eq) 3.22) in the combined study sample. In addition, we detected suggestive univariate linkage (LOD 1.9-2.93) on chromosomes 4p-q, 6p, 7q, 9q, 11q, 12q 13q, 15q, 16p, 18q, 19p, 19q and Xq23 and suggestive bivariate linkage (LOD(eq) 2.05-2.62) on chromosomes 6p, 7q, 12p, 12q, and 19p-q. In conclusion, chromosome 6p and 12q may host promising susceptibility loci influencing lipid levels; however, the low degree of overlap between the three study samples strongly encourages further studies of the lipid-related traits.
Aberg
Karolina
K
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Dai
Feng
F
Sun
Guangyun
G
Keighley
Ember
E
Indugula
Subba Rao
SR
Bausserman
Linda
L
Viali
Satupaitea
S
Tuitele
John
J
Deka
Ranjan
R
Weeks
Daniel E
DE
McGarvey
Stephen T
ST
D000328:Adult; D000428:Alcohol Drinking; D000704:Analysis of Variance; D002875:Chromosomes; D004493:Education; D004777:Environment; D005260:Female; D008040:Genetic Linkage; D015894:Genome, Human / Q000235:genetics*; D023281:Genomics; D006801:Humans; D008055:Lipids / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D009043:Motor Activity; D018947:Samoa; D012907:Smoking; D012984:Software
D008055:Lipids