[Inhibiting effects of fucoidans on Hantaan virus adsorption on a model of peritoneal macrophages in vitro].
A model of peritoneal macrophages was used to study the effect of fucoidans from brown seaweeds on the adsorption of Hantaan virus. Fucoidans were found to have antiviral activity, but to differ in the inhibition of hantavirus adsorption, which was associated with their structural features. The mechanism of their action is assumed to be shown via ligand-receptor interaction with certain cell membrane receptors and via blockage of hantavirus glycoproteins (G1 and G2), resulting in adsorption inhibition and preventing viral penetration into the macrophages.
Makarenkova
I D
ID
Kompanets
G G
GG
Besednova
N N
NN
Slonova
R A
RA
Zviagintseva
T N
TN
Shevchenko
N M
NM
D000818:Animals; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D018063:Hantaan virus / Q000187:drug effects* / Q000502:physiology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000188:drug therapy / Q000821:virology; D017737:Macrophages, Peritoneal / Q000821:virology*; D051379:Mice; D011134:Polysaccharides / Q000494:pharmacology*; D014709:Vero Cells; D014760:Viral Fusion Proteins / Q000187:drug effects; D053585:Virus Attachment / Q000187:drug effects
D011134:Polysaccharides; D014760:Viral Fusion Proteins; C007789:fucoidan