[Statins and neuromuscular pathology].
BACKGROUND
Statins represent a group of pharmaceutical agents with proven effectiveness and scarce side effects; however, their widespread use increases the probability of the appearance of such adverse effects.


METHODS
We reviewed the articles that have been published on myotoxicity, neurotoxicity and other cases of disorders affecting the peripheral nervous system, both in reviews and in clinical trials and isolated cases. The frequency of appearance, clinical repercussion, proposed physiopathogenetic mechanisms were analysed in order to draw conclusions regarding the therapeutic attitude that should be adopted.


CONCLUSIONS
Generally speaking they are safe pharmaceuticals, but the physician must pay attention to the appearance of possible side effects, given their potential reversibility and lower degree of severity if they are diagnosed at an early stage.
Turpin-Fenoll
L
L
Sección de Neurología, Hospital Virgen de la Luz, Cuenca, España. lturdoc@hotmail.com
Millan-Pascual
J
J
Martin-Estefania
C
C
D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D009135:Muscular Diseases / Q000139:chemically induced* / Q000453:epidemiology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000453:epidemiology; D015995:Prevalence
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors