title: Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats.
abstract: A 3-week chronic mild stress (CMS) protocol decreased sucrose preference of rats and increased immobility in the forced swim test. It also induced social avoidance and increased grooming, but acted as if reducing anxiety in the plus-maze. Sucrose preference and social avoidance, but not other measures of the behaviour, showed significant correlation. We conclude that CMS-induced depression-like behaviour is associated with social avoidance, a seemingly anxiety-related measure, but not with other anxiety-like traits in rats.
authors.affiliation: Department of Preclinical Research, EGIS Pharmaceuticals Plc., Budapest, Hungary.
authors.forename: Hajnalka
authors.initials: H
authors.lastname: Kompagne
authors.forename: György
authors.initials: G
authors.lastname: Bárdos
authors.forename: Gábor
authors.initials: G
authors.lastname: Szénási
authors.forename: István
authors.initials: I
authors.lastname: Gacsályi
authors.forename: László G
authors.initials: LG
authors.lastname: Hársing
authors.forename: György
authors.initials: G
authors.lastname: Lévay
mesh_terms: D000818:Animals; D001007:Anxiety / Q000503:physiopathology* / Q000523:psychology; D001522:Behavior, Animal / Q000502:physiology*; D003863:Depression / Q000503:physiopathology / Q000523:psychology; D005106:Exploratory Behavior / Q000502:physiology; D005518:Food Preferences / Q000502:physiology / Q000523:psychology; D006120:Grooming / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical / Q000379:methods; D012919:Social Behavior; D013315:Stress, Psychological / Q000503:physiopathology* / Q000523:psychology; D013395:Sucrose / Q000008:administration & dosage; D013550:Swimming / Q000523:psychology; D013997:Time Factors
chemical_list: D013395:Sucrose