title: Micro-computerized tomography analysis: dynamics of bone augmentation within a titanium cap in rabbit calvarium.
abstract: OBJECTIVE
  A new microfocus computerized tomography (R-mCT) system that quickly produces clear images of the bones of small animals allows the continuous observation of living experimental animals. This study used the new R-mCT system to examine the dynamics of marrow penetration within a titanium cap in rabbit calvarium.
  
  
  METHODS
  In a rabbit, the calvarium was exposed, and circular grooves were prepared bilaterally. Within the circular groove, the external cortical surface of the skull was perforated mechanically. The rate of penetration was 28% (experiment) or 14% (control). Images of bone augmentation within the titanium cap were taken using R-mCT.
  
  
  RESULTS
  The augmented mineralized tissue increased gradually with repeated resorption and acceleration. The dynamics of bone augmentation did not differ with the penetration rate.
  
  
  CONCLUSIONS
  Accurate noninvasive longitudinal monitoring of bone augmentation or response to therapy can now be done in the same living animal by using R-mCT.
authors.affiliation: Division of Applied Oral Sciences, Nihon University School of Dentistry, Tokyo, Japan.
authors.forename: Seiko
authors.initials: S
authors.lastname: Min
authors.forename: Shuichi
authors.initials: S
authors.lastname: Sato
authors.forename: Masakazu
authors.initials: M
authors.lastname: Saito
authors.forename: Hajime
authors.initials: H
authors.lastname: Ebihara
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Arai
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000502:physiology*; D001861:Bone Regeneration; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D008297:Male; D011817:Rabbits; D012886:Skull / Q000601:surgery; D014025:Titanium; D055114:X-Ray Microtomography
chemical_list: D014025:Titanium