title: Exploring poly-beta-hydroxy-butyrate metabolism through network-based extreme pathway analysis.
abstract: The objective of this article is to obtain a more detailed insight into poly-beta-hydroxybutyrate (PHB) metabolism through network-based metabolic pathway analysis. We employ extreme pathways to perform this study, because calculating and interpreting extreme pathways is a promising way for pathway analysis and metabolic engineering. After giving an in silico model of butanoate metabolism of Bacillus thuringiensis 97-27 (btk), extreme pathways were calculated and classified. Furthermore, the type I and II extreme pathways were further classified and analyzed in detail based on their structure and functional capabilities. Besides "historical" biochemical pathways, the results also suggest that there are some novel pathways.
authors.affiliation: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
authors.forename: Dewu
authors.initials: D
authors.lastname: Ding
authors.forename: Yanrui
authors.initials: Y
authors.lastname: Ding
authors.forename: Yujie
authors.initials: Y
authors.lastname: Cai
authors.forename: Shouwen
authors.initials: S
authors.lastname: Chen
authors.forename: Wenbo
authors.initials: W
authors.lastname: Xu
mesh_terms: D000105:Acetyl Coenzyme A / Q000378:metabolism; D001413:Bacillus thuringiensis / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism; D003198:Computer Simulation; D006885:Hydroxybutyrates / Q000378:metabolism*; D053858:Metabolic Networks and Pathways / Q000502:physiology; D008954:Models, Biological; D011091:Polyesters / Q000378:metabolism*; D000094122:Polyhydroxybutyrates
chemical_list: D000105:Acetyl Coenzyme A; D001426:Bacterial Proteins; D006885:Hydroxybutyrates; D011091:Polyesters; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates