The biological activity of derivatives of 2-[(o-; and p-substituted)aminophenyl]-3H-5-[(o-; and p-substituted)phenyl]-7-chloro-1,4-benzodiazepines and 1-alkyl-3H-5-[(o-; and p- substituted) phenyl]-7-chloro-1,4-benzodiazepin-2-one.
Eight of a series of twelve new 2-[(o-; and p-substituted)aminophenyl]-3H-5-[(o-; and p-substituted)phenyl]-7-chloro-1,4-benzodiazepinines (VI, 1-12; Fig. 1) and two of eleven new 1-alkyl-3H-5-[(o-; and p-substituted)phenyl]-7-chloro-1,4-benzodiazepin-2-one (IV, 1-12; Fig. 2) were tested for their pharmacological and/or biological activity as anxiolytics.
Cortés-Cortés
Eduardo
E
Instituto de Química, Universidad Nacional Autónoma de México, México. ecortés@servidor.unam.mx
Salazar Franco
Raúl
R
Ebromares Martínez
Isidro
I
García-Mellado De Cortés
Olivia
O
Naranjo-Rodríguez
Elia Brosla
EB
López-Rubalcava
Carolina
C
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D001007:Anxiety / Q000188:drug therapy / Q000523:psychology; D001156:Artemia; D001522:Behavior, Animal / Q000187:drug effects; D001570:Benzodiazepinones / Q000494:pharmacology*; D003624:Darkness; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D007928:Lethal Dose 50; D008027:Light; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones