title: Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis.
abstract: OBJECTIVE
  To evaluate the efficacy and tolerability of a vaginal pessary containing 750 mg of metronidazole and 200 mg of miconazole nitrate used daily for 7 days in the treatment of vaginitis.
  
  
  METHODS
  Ninety-two women with vaginitis participated in this phase 3 study using one vaginal pessary daily for 7 days. Gynecological and microbiological evaluations were carried out prior to and following treatment.
  
  
  RESULTS
  Reductions occurred in symptoms and signs of vaginitis. Clinical cure rate was 87.7%, while the cure rates according to microscopy and Candida albicans culture were 81.8% and 73.9%, respectively. The cure rate for bacterial vaginosis was 75% and culture of Gardnerella vaginalis turned negative in 63.6% of cases following treatment. The medication was well tolerated.
  
  
  CONCLUSIONS
  Use of a combination of 750 mg of metronidazole and 200 mg of miconazole in a single daily application was found to be effective in the treatment of the most common causes of vaginitis.
authors.affiliation: Laboratory of Human Reproduction, Teaching Hospital, Federal University of Minas Gerais, Brazil. fabiocpeixoto@terra.com.br
authors.forename: Fabio
authors.initials: F
authors.lastname: Peixoto
authors.forename: Aroldo
authors.initials: A
authors.lastname: Camargos
authors.forename: Geraldo
authors.initials: G
authors.lastname: Duarte
authors.forename: Iara
authors.initials: I
authors.lastname: Linhares
authors.forename: Luis
authors.initials: L
authors.lastname: Bahamondes
authors.forename: Alvaro
authors.initials: A
authors.lastname: Petracco
mesh_terms: D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006194:Gardnerella vaginalis / Q000187:drug effects*; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage* / Q000009:adverse effects; D008825:Miconazole / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D010570:Pessaries; D014247:Trichomonas Vaginitis / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D008795:Metronidazole; D008825:Miconazole