title: Serum concentration of interleukin-6 is increased both in active and remission stages of pemphigus vulgaris.
abstract: As most studies on pemphigus vulgaris (PV) pathogenesis concern its active stage, we aimed to evaluate the serum concentration of TNF-alpha, IL-1, and IL-6 in PV patients in clinical remission. The study group consisted of sera from 19 PV patients in active stage and from 24 patients in clinical remission. 19 sera taken from healthy subjects served as the controls. Serum IL-6 concentrations in PV active and PV remission group were significantly higher when compared to the controls (P < .05). In patients in active stage of PV, a significant correlation between serum IL-1 and IL-6 concentrations was found (r(P) = 0.46; P < .05). We also found a negative correlation between TNF-alpha level and pemphigus antibodies titer in the patients from the remission group (r(S) = -0.47303; P < .02). Our data suggest that IL-6 and TNF-alpha may be involved in maintaining immunological disturbances in remission stage of PV.
authors.affiliation: Department of Dermatology, Medical University of Lodz, 94-017 Lodz, Poland. joanna.narbutt@onet.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Narbutt
authors.forename: Jolanta
authors.initials: J
authors.lastname: Lukamowicz
authors.forename: Jarosław
authors.initials: J
authors.lastname: Bogaczewicz
authors.forename: Anna
authors.initials: A
authors.lastname: Sysa-Jedrzejowska
authors.forename: Jolanta Dorota
authors.initials: JD
authors.lastname: Torzecka
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Lesiak
mesh_terms: D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D010392:Pemphigus / Q000097:blood* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha