Protein kinase C signalling in leukemia.
The protein kinase C (PKC) family of proteins includes several kinases that share structural homology, but at the same time exhibit substantial functional diversity. There is a significant amount of evidence establishing distinct patterns of expression and function for different PKC isoforms and groups in different leukemias. Although most members of this family promote leukemic cell survival and growth, others exhibit opposing effects and participate in the generation of antileukemic responses. This review summarizes work in this field on the relevance of distinct members of the PKC family in the pathophysiology of myeloid and lymphoid leukemias. The clinical-therapeutic potential of such ongoing work for the treatment of future development of novel approaches for the treatment of different types of leukemias is discussed.
Redig
Amanda J
AJ
Robert H. Lurie Comprehensive Cancer Center and Division of Hematology/Oncology, Northwestern University Medical School and Lakeside VA Medical Center, Chicago, IL 60611, USA.
Platanias
Leonidas C
LC
D049109:Cell Proliferation; D002470:Cell Survival; D006801:Humans; D007527:Isoenzymes; D007938:Leukemia / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D015398:Signal Transduction
D007527:Isoenzymes; D047428:Protein Kinase Inhibitors; D011493:Protein Kinase C