title: Studies of macrophage immuno-modulating activity of polysaccharides isolated from Paecilomyces tenuipes.
abstract: The objective of this study was to evaluate the immunomodulatory effects of the Paecilomyces sinensis polysaccharides (PtP) on the activity of macrophages and human monocytes. A water-soluble polysaccharide, with estimated molecular weight of 2.04x10(4) Da, was isolated from P. sinensis. The results indicate that PtP can increase the activity of LDH and ACP in AMphi and PMphi of rats and human mononuclear cells, and enhance the pinocytic activity of macrophages and TNF-alpha production by human peripheral blood mononuclear cells (PBMC), suggesting that PtP had potent immunomodulatory properties and could be explored as a novel potential immunostimulants for the food and pharmaceutical purpose.
authors.affiliation: Institute of Cellular and Molecular Medicine, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine, Wenzhou Medical College, Wenzhou 325035, PR China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Chen
authors.forename: Jianxin
authors.initials: J
authors.lastname: Lu
authors.forename: Yangde
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jiantai
authors.initials: J
authors.lastname: He
authors.forename: Xunzhi
authors.initials: X
authors.lastname: Guo
authors.forename: Gengyuan
authors.initials: G
authors.lastname: Tian
authors.forename: Liqin
authors.initials: L
authors.lastname: Jin
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D006801:Humans; D007155:Immunologic Factors / Q000302:isolation & purification* / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology*; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000201:enzymology / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000201:enzymology / Q000276:immunology; D009000:Monocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D010143:Paecilomyces / Q000737:chemistry*; D010873:Pinocytosis / Q000187:drug effects; D011134:Polysaccharides / Q000302:isolation & purification* / Q000494:pharmacology*; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D007155:Immunologic Factors; D011134:Polysaccharides; D014409:Tumor Necrosis Factor-alpha; D007770:L-Lactate Dehydrogenase; D000135:Acid Phosphatase