[Polymorphisms of GSTM1, GSTT1 and CYP1A1 genes in mothers and neonates related to susceptibility to preterm delivery].
OBJECTIVE
Objective Based on the distribution of genetic polymorphisms of GSTM1 ,GSTT1 and CYP1A1 genotypes in mothers and neonates with preterm delivery and health controls, to explore the relationship between these gene polymorphisms and susceptibility to preterm delivery.


METHODS
we investigated mothers and neonates with preterm delivery and health controls were investigated by case-control method. The frequencies of GSTM1, GSTr1 and CYP1A1 genotypes were detected by PCR and RFLP-PCR techniques.


RESULTS
The difference of variation frequencies of GSTM1, GSTT1 and CYP1A1 (Msp I polymorphism) genotypes between cases (mothers and neonates respectively) and their health controls were not statistically significant (P > 0.05). The difference of variation frequencies of GSTM1 and GSTT1 combined between mother cases group and control groups were not statistically significant (P > 0.05). The neonates was same as mother groups. However, the differences of CYP1A1 heterozygous mutation and homozygous mutation gene combined with the null genotypes among GSTT1 between mother groups with preterm delivery and health controls were statistically significant (chi2 = 4.683, P < 0.05, OR = 2.440).


CONCLUSIONS
CYP1A1 heterozygous mutation and homozygous mutation gene combined with GSTT1 null genotypes in mothers could increase the risk of preterm delivery.
Zhang
Meiyun
M
Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Cheng
Yibin
Y
Dong
Shaoxia
S
Liu
Ya
Y
et al
D000328:Adult; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D009154:Mutation; D011110:Polymorphism, Genetic; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics*
D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1