title: Transient global amnesia: diffusion-weighted imaging lesions and cerebrovascular disease.
abstract: OBJECTIVE
  A hypoxic-ischemic origin of transient global amnesia (TGA) has been suggested on the basis of the observation of infarctlike diffusion-weighted imaging (DWI) abnormalities in some affected individuals. We tested this hypothesis by comparing vascular risk factors, magnetic resonance imaging (MRI) markers of cerebral small-vessel disease, and other evidence of a cerebrovascular disorder between TGA patients with (DWI+) and without (DWI-) DWI lesions and normal community-based controls.
  
  
  METHODS
  We retrospectively identified 86 patients hospitalized for TGA (mean+/-SD age, 65.9+/-10.9 years; 62% female). Brain MRI at 1.5 T was assessed for DWI lesions exhibiting restricted diffusion (ie, DWI+), white-matter hyperintensities, lacunes, and chronic infarcts (median time lag to clinical onset, 66.6+/-54.6 hours). Vascular risk factors and findings from duplex sonography, ECG, and echocardiography were recorded. A 1:2 age- and sex-matched sample of 172 elderly subjects (mean+/-SD age, 65.6+/-9.3 years; 62% female) free of neuropsychiatric disease served for comparison.
  
  
  RESULTS
  DWI lesions were observed in 10 patients with TGA (11.5%; mean+/-SD age, 68.3+/-5.4 years; 8 women). They were all small and located in the mesiotemporal region (9 left hemisphere, 5 right hemisphere). The vascular risk profile of TGA patients and concomitant changes on brain MRI were comparable with those of healthy controls and did not show significant differences between DWI+ and DWI- subjects. A comprehensive diagnostic workup also provided no evidence for a higher rate of cerebrovascular disorder-related abnormalities in either the total group of TGA patients or TGA DWI+ patients.
  
  
  CONCLUSIONS
  These findings do not support a cerebrovascular etiology of TGA, even in those individuals showing acute DWI lesions. Other pathophysiologic mechanisms need to be explored.
authors.affiliation: Department of Neurology and Section of Neuroradiology, Medical University of Graz, Auenbruggerplatz 22, A-8036 Graz, Austria. chris.enzinger@meduni-graz.at
authors.forename: Christian
authors.initials: C
authors.lastname: Enzinger
authors.forename: Felix
authors.initials: F
authors.lastname: Thimary
authors.forename: Peter
authors.initials: P
authors.lastname: Kapeller
authors.forename: Stefan
authors.initials: S
authors.lastname: Ropele
authors.forename: Reinhold
authors.initials: R
authors.lastname: Schmidt
authors.forename: Franz
authors.initials: F
authors.lastname: Ebner
authors.forename: Franz
authors.initials: F
authors.lastname: Fazekas
mesh_terms: D000368:Aged; D020236:Amnesia, Transient Global / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D020520:Brain Infarction / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D002560:Cerebrovascular Circulation; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D018616:Ultrasonography, Doppler, Duplex