Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein.
The kinetics of peptide presentation by major histocompatibility complex class I (MHC-I) molecules may contribute to the efficacy of CD8+ T cells. Whether all CD8+ T-cell epitopes from a protein are presented by the same MHC-I molecule with similar kinetics is unknown. Here we show that CD8+ T-cell epitopes derived from SIVmac239 Gag are presented with markedly different kinetics. We demonstrate that this discrepancy in presentation is not related to immunodominance but instead is due to differential requirements for epitope generation. These results illustrate that significant differences in presentation kinetics can exist among CD8+ T-cell epitopes derived from the same viral protein.
Sacha
Jonah B
JB
Wisconsin National Primate Research Center (WNPRC), Madison, WI 53711, USA.
Reynolds
Matthew R
MR
Buechler
Matthew B
MB
Chung
Chungwon
C
Jonas
Anna K
AK
Wallace
Lyle T
LT
Weiler
Andrea M
AM
Lee
Wonhee
W
Piaskowski
Shari M
SM
Soma
Taeko
T
Friedrich
Thomas C
TC
Wilson
Nancy A
NA
Watkins
David I
DI
D000818:Animals; D017951:Antigen Presentation / Q000502:physiology*; D000938:Antigen-Presenting Cells; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D015683:Gene Products, gag / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism*; D016056:Immunodominant Epitopes; D007700:Kinetics; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000378:metabolism*
D018984:Epitopes, T-Lymphocyte; D015683:Gene Products, gag; D015395:Histocompatibility Antigens Class I; D016056:Immunodominant Epitopes