Applications of enantioselective carbolithiation of ortho-substituted beta-methylstyrenes.
The enantioselective carbolithiation of ortho-substituted (E)-beta-methylstyrenes provides access to chiral lithiated intermediates with broad synthetic potential. Specifically, beta-methylstyrenes with o-aminomethyl, ether, and oxazoline groups have been employed in the synthesis of chiral aromatics and heteroaromatics such as isoquinolines, isoquinolinones, benzofurans, and isobenzofuranones.
Hogan
Anne-Marie L
AM
Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
Tricotet
Thomas
T
Meek
Alastair
A
Khokhar
Shaista S
SS
O'Shea
Donal F
DF