title: Acute disseminated encephalomyelitis in a renal transplant recipient: a case report.
abstract: Acute disseminated encephalomyelitis (ADEM) is an acute demyelinating disorder of the central nervous system, mostly seen in children after viral or bacterial infection and vaccinations. Cases of ADEM, albeit rare, have been reported in renal transplant recipients. The pathophysiology of posttransplant ADEM remains unclear but has been hypothesized to be due to aberrant T-cell reactivity to myelin basic protein triggered by a bacterial or viral infection. We report an unusual case of a 34-year-old white female with ADEM developing 5 years after a living related renal transplant.
authors.affiliation: Division of Organ Transplantation, Rhode Island Hospital, Providence, Rhode Island, USA. ayango@lifespan.org
authors.forename: M
authors.initials: M
authors.lastname: Aboagye-Kumi
authors.forename: A
authors.initials: A
authors.lastname: Yango
authors.forename: S
authors.initials: S
authors.lastname: Fischer
authors.forename: J
authors.initials: J
authors.lastname: Donahue
authors.forename: P
authors.initials: P
authors.lastname: Morrissey
authors.forename: N
authors.initials: N
authors.lastname: Taylor
authors.forename: A
authors.initials: A
authors.lastname: Gautam
authors.forename: C
authors.initials: C
authors.lastname: Mendonca
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.forename: R
authors.initials: R
authors.lastname: Gohh
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001991:Bronchitis / Q000175:diagnosis / Q000188:drug therapy; D015377:Cilastatin / Q000627:therapeutic use; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis* / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D005911:Gliosis / Q000175:diagnosis; D005921:Glomerulonephritis / Q000150:complications*; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D015377:Cilastatin; D015378:Imipenem