[Effects of beta-asarone on expression of FOS and GAD65 in cortex of epileptic rat induced by penicillin].
OBJECTIVE
To study effects of beta-asarone on expression of FOS and GAD65 in cortex of epileptic rat induced by penicillin.


METHODS
The epileptic animal models were induced by penicillin. The rats were randomly divided into beta-asarone of high (100 mg/kg), medium (50 mg/kg), low (25 mg/kg) dose group, positive control group (Phenytoin sodium), negative control group (matrix). The medicine was administered orally. The effects of beta-asarone on expression of FOS and GAD65 in cortex of epileptic rat were detected by immuohistochemistry method.


RESULTS
beta-asarone could raise expression of FOS and reduce expression of GAD65 obviously. There were significant differences between negative control group and beta-asarone group. And it showed significant dose-effect relationship.


CONCLUSIONS
Up-regulation of FOS may be a effective link of anti-epileptic effect of beta-asarone; reduced expression of GAD65 may be a follow-up impact of beta-asarone treatment.
Fu
Si-ying
SY
The First Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510405, China.
Fang
Ruo-ming
RM
Fang
Geng-li
GL
Xie
Yu-hui
YH
Fang
Yong-qi
YQ
D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D029064:Araceae / Q000737:chemistry; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D010406:Penicillins; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000927:Anticonvulsants; D004365:Drugs, Chinese Herbal; D010406:Penicillins; D016760:Proto-Oncogene Proteins c-fos; C012195:asarone; D005968:Glutamate Decarboxylase