title: Shedding of live vaccine virus, comparative safety, and influenza-specific antibody responses after administration of live attenuated and inactivated trivalent influenza vaccines to HIV-infected children.
abstract: HIV-infected children (N=243), >or=5 to <18 years old, receiving stable antiretroviral therapy, were stratified by immunologic status and randomly assigned to receive intranasal live attenuated influenza vaccine (LAIV) or intramuscular trivalent inactivated influenza vaccine (TIV). The safety profile after LAIV or TIV closely resembled the previously reported tolerability to these vaccines in children without HIV infection. Post-vaccination hemagglutination inhibition (HAI) antibody responses and shedding of LAIV virus were also similar, regardless of immunological stratum, to antibody responses and shedding previously reported for children without HIV infection. LAIV should be further evaluated for a role in immunizing HIV-infected children.
authors.affiliation: University of Colorado School of Medicine, Aurora, CO 80045-0508, United States. myron.levin@uchsc.edu
authors.forename: Myron J
authors.initials: MJ
authors.lastname: Levin
authors.forename: Lin-Ye
authors.initials: LY
authors.lastname: Song
authors.forename: Terrence
authors.initials: T
authors.lastname: Fenton
authors.forename: Sharon
authors.initials: S
authors.lastname: Nachman
authors.forename: Julie
authors.initials: J
authors.lastname: Patterson
authors.forename: Robert
authors.initials: R
authors.lastname: Walker
authors.forename: George
authors.initials: G
authors.lastname: Kemble
authors.forename: Maria
authors.initials: M
authors.lastname: Allende
authors.forename: Micki
authors.initials: M
authors.lastname: Hultquist
authors.forename: Tingting
authors.initials: T
authors.lastname: Yi
authors.forename: Barbara
authors.initials: B
authors.lastname: Nowak
authors.forename: Adriana
authors.initials: A
authors.lastname: Weinberg
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007252:Influenza Vaccines / Q000009:adverse effects* / Q000276:immunology*; D007273:Injections, Intramuscular; D008297:Male; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology; D015164:Vaccines, Inactivated / Q000009:adverse effects / Q000276:immunology; D017201:Virus Shedding
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated