Cancer-associated antigens and antigen arrays in serological diagnostics of malignant tumors.
The appearance of antibodies to cancer-associated antigens in biological fluids (particularly, in blood sera) of cancer patients is now a well-established fact, and their detection by immunochemical methods is a promising approach to diagnostics of malignant neoplasms. In this review, we consider some immunobiological aspects of the most extensively studied cancer-associated B-cell antigens, various applications of autoantibodies as cancer biomarkers, and prospects for the use of antigen arrays for improving diagnostic sensitivity.
Belousov
P V
PV
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia. belous_p@rambler.ru
Kuprash
D V
DV
Sazykin
A Yu
AY
Khlgatian
S V
SV
Penkov
D N
DN
Shebzukhov
Yu V
YV
Nedospasov
S A
SA
D000818:Animals; D000951:Antigens, Neoplasm / Q000097:blood* / Q000235:genetics / Q000276:immunology; D001324:Autoantigens / Q000097:blood / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation; D006801:Humans; D046228:Microarray Analysis; D009369:Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D012698:Serologic Tests
D000951:Antigens, Neoplasm; D001324:Autoantigens