title: A new sesquiterpenoid hydroquinone from the marine sponge Dysidea arenaria.
abstract: Detailed chemical investigation of the South China sponge Dysidea arenaria resulted in the isolation of a new sesquiterpenoid hydroquinone, 19-hydroxypolyfibrospongol B (1), along with five known compounds: polyfibrospongol B (2), isosemnonorthoquinone (3), ilimaquinone (4), smenospongine (5) and smenotronic acid (6). The structures were determined by extensive spectroscopic analysis. The in vitro anti- HIV activity on HIV-1 RT was evaluated. Compounds 3 -6 displayed moderate inhibitory activity, with IC(50)values of 239.7, 16.4, 176.1, and 130.4 microM, respectively, while 1 and 2 were found to be inactive against the same biological target.
authors.affiliation: Department of Pharmacy, School of Medical, Xiamen University, Xiamen 361005, People's Republic of China. yanqiu@xmu.edu.cn
authors.forename: Yan
authors.initials: Y
authors.lastname: Qiu
authors.forename: Xiu Min
authors.initials: XM
authors.lastname: Wang
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004353:Drug Evaluation, Preclinical; D047088:Dysidea / Q000737:chemistry*; D006873:Hydroquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D019380:Anti-HIV Agents; D006873:Hydroquinones; D018894:Reverse Transcriptase Inhibitors; D012717:Sesquiterpenes; C031927:hydroquinone