Effect of 1-beta-D-arabinofuranosylcytosine on cell cycle passage time.
1-beta-D-Arabinofuranosylcytosine (ara-C) affects the passage rate of cells from S to G2 phase to a greater extent than from G1 to S. This finding is consistent with the fact that the compound may have its major biological effect during the latter part of S and the early part of G2. The magnitude of these effects is related to the dose and duration of ara-C administration. Inhibition of DNA synthesis can occur without disturbances in transit time.
Karon
M
M
Laboratory of Cellular Pharmacology, Division of Hematology, Children's Hospital of Los Angeles, California, USA.
Shirakawa
S
S
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D006224:Cricetinae; D003561:Cytarabine / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism; D016195:G2 Phase / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects; D016196:S Phase / Q000187:drug effects; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine; D013936:Thymidine