title: Canine histiocytic diseases.
abstract: Canine histiocytic diseases are an emerging spectrum of diseases characterized by proliferations of histiocytic cells. Nonneoplastic histiocytic disease (reactive histiocytosis, comprising cutaneous and systemic histiocytosis) is uncommon. Neoplastic histiocytic diseases include cutaneous histiocytoma, which is a benign histiocytic tumor, and localized and disseminated histiocytic sarcoma (previously known as malignant histiocytosis), which are malignant diseases. The differentiation of histiocytic diseases can be challenging. This article outlines the characteristics of each disease entity and details the clinicopathologic, histologic, immunohistochemical, prognostic, and therapeutic differences among them.
authors.affiliation: University of Florida, FL, USA.
authors.forename: Alastair R
authors.initials: AR
authors.lastname: Coomer
authors.forename: Julius M
authors.initials: JM
authors.lastname: Liptak
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D004285:Dogs; D051642:Histiocytoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D015614:Histiocytosis / Q000175:diagnosis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D011379:Prognosis; D012871:Skin Diseases / Q000175:diagnosis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*