title: Clinical and laboratory evaluations of non-surgical periodontal treatment in subjects with diabetes mellitus.
abstract: BACKGROUND
  The aim of this study was to evaluate the clinical and laboratory changes 3 months after full-mouth scaling and root planing in subjects with and without diabetes mellitus.
  
  
  METHODS
  This study was performed using 10 subjects with type 2 diabetes mellitus who required insulin therapy (DM) and 10 healthy adult control subjects (NDM) with generalized chronic periodontal disease. Both groups were treated with full-mouth scaling and root planing and given oral hygiene instructions. Clinical parameters, including plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR), and clinical attachment level (CAL), were measured at four sites per tooth. Subgingival plaque samples were obtained from sites with the deepest PD (> or =5 mm) and with furcations in each subject. Samples were also tested for the presence of Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans), Porphyromonas gingivalis, and Tannerella forsythia (previously T. forsythensis) by polymerase chain reaction. Glycemic control (glycosylated hemoglobin [HbA1c] and fasting glucose levels) and clinical and microbiologic assessments were recorded at baseline and 3 months after periodontal treatment.
  
  
  RESULTS
  Data revealed statistical changes (P < or =0.05; analysis of variance [ANOVA]) in clinical variables (PI, GI, PD, GR, and CAL) between baseline and 3 months in both groups. Conversely, no improvement in the fasting glucose level or glycosylated hemoglobin (P < or =0.05; ANOVA) was found after treatment. Besides some reduction in the bacterial frequency 3 months after treatment, no statistically significant difference was found between the groups.
  
  
  CONCLUSIONS
  Clinical and laboratory responses were similar in DM and NDM groups 3 months after full-mouth scaling and root planing.
authors.affiliation: Department of Prosthodontics and Periodontics, Division of Periodontics, Piracicaba Dental School, State University of Campinas, São Paulo, SP, Brazil. gabyccruz@fop.unicamp.br
authors.forename: Gabriela Alessandra
authors.initials: GA
authors.lastname: da Cruz
authors.forename: Sergio
authors.initials: S
authors.lastname: de Toledo
authors.forename: Enilson Antonio
authors.initials: EA
authors.lastname: Sallum
authors.forename: Antonio Wilson
authors.initials: AW
authors.lastname: Sallum
authors.forename: Gláucia Maria Bovi
authors.initials: GM
authors.lastname: Ambrosano
authors.forename: Janaina
authors.initials: J
authors.lastname: de Cássia Orlandi Sardi
authors.forename: Sérgio Eduardo Braga
authors.initials: SE
authors.lastname: da Cruz
authors.forename: Reginaldo Bruno
authors.initials: RB
authors.lastname: Gonçalves
mesh_terms: D000328:Adult; D000368:Aged; D016976:Aggregatibacter actinomycetemcomitans / Q000302:isolation & purification; D001439:Bacteroides / Q000302:isolation & purification; D001786:Blood Glucose / Q000032:analysis; D002908:Chronic Disease; D003773:Dental Plaque / Q000382:microbiology; D003774:Dental Plaque Index; D012534:Dental Scaling; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000628:therapy; D005889:Gingival Recession / Q000628:therapy; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008875:Middle Aged; D009910:Oral Hygiene; D017622:Periodontal Attachment Loss / Q000628:therapy; D010510:Periodontal Diseases / Q000628:therapy*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000628:therapy; D016966:Porphyromonas gingivalis / Q000302:isolation & purification; D016745:Root Planing
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin