title: Ethanol exposure during late gestation and nursing in the rat: effects upon maternal care, ethanol metabolism and infantile milk intake.
abstract: Ethanol experiences, during late gestation as well as during nursing, modify the behavioral dynamics of the dam/pup dyad, and leads to heightened ethanol intake in the offspring. This study focuses on: a) behavioral and metabolic changes in intoxicated dams with previous exposure to ethanol during pregnancy and b) infantile consumption of milk when the dam is either under the effects of ethanol or sober. Pregnant rats received water, 1.0 or 2.0 g/kg ethanol, and were administered with water or ethanol during the postpartum period. Intoxication during nursing disrupted the capability of the dam to retrieve the pups and to adopt a crouching posture. These disruptions were attenuated when dams had exposure to ethanol during pregnancy. Ethanol experiences during gestation did not affect pharmacokinetic processes during nursing, whereas progressive postpartum ethanol experience resulted in metabolic tolerance. Pups suckling from intoxicated dams, with previous ethanol experiences, ingested more milk than did infants suckling from ethanol-intoxicated dams without such experience. Ethanol gestational experience results in subsequent resistance to the drug's disruptions in maternal care. Consequently, better maternal care by an intoxicated dam with ethanol experience during gestation facilitates access of pups to milk which could be contaminated with ethanol.
authors.affiliation: Instituto de Investigación Médica M. y M. Ferreyra (INIMEC - CONICET), Córdoba, C.P 5016, Argentina. mpueta@immf.uncor.edu
authors.forename: Mariana
authors.initials: M
authors.lastname: Pueta
authors.forename: Paula
authors.initials: P
authors.lastname: Abate
authors.forename: Olga B
authors.initials: OB
authors.lastname: Haymal
authors.forename: Norman E
authors.initials: NE
authors.lastname: Spear
authors.forename: Juan C
authors.initials: JC
authors.lastname: Molina
mesh_terms: D000435:Alcoholic Intoxication / Q000523:psychology; D000818:Animals; D000831:Animals, Newborn / Q000523:psychology*; D000833:Animals, Suckling / Q000523:psychology*; D001724:Birth Weight / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000097:blood / Q000378:metabolism* / Q000633:toxicity*; D000431:Ethanol / Q000097:blood / Q000378:metabolism* / Q000633:toxicity*; D005260:Female; D007774:Lactation / Q000502:physiology*; D008098:Litter Size / Q000187:drug effects; D008425:Maternal Behavior / Q000187:drug effects*; D049590:Postpartum Period; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol