title: Fontan fenestration closure has no acute effect on exercise capacity but improves ventilatory response to exercise.
abstract: OBJECTIVE
  The aim of this study was to prospectively examine the effects of elective Fontan fenestration closure upon exercise capacity and ventilatory abnormalities.
  
  
  BACKGROUND
  For patients undergoing Fontan procedures as palliation of single ventricle physiology, the addition of a fenestration to the procedure mitigates perioperative morbidity. Although some fenestrations may close spontaneously, many remain patent and subject patients to arterial hypoxemia and risk for paradoxical emboli. For these reasons fenestration closure is routinely performed post-operatively in the cardiac catheterization laboratory. Although closure of Fontan fenestrations typically results in an immediate improvement in systemic arterial oxygen saturation, it is also associated with an acute decrease in cardiac index and systemic O(2) delivery. The sum result of these physiologic changes upon exercise capacity has not been examined.
  
  
  METHODS
  Twenty consecutive patients, age 5 to 46 (median 10) years, underwent pre- and post-fenestration closure exercise testing with expiratory gas analysis.
  
  
  RESULTS
  Before fenestration closure, peak oxygen consumption (VO(2)) was depressed and there was systemic desaturation at rest that worsened with exercise. The ventilatory response to exercise was also abnormal, characterized by elevation of the minute ventilation (VE)/CO(2) elimination slope (VE/VCO(2)), a low end-tidal CO(2), and high end-tidal O(2) at the ventilatory anaerobic threshold. Although arterial saturation improved significantly after fenestration closure, there was no change in peak VO(2) (70.9 +/- 18.6% to 74.0 +/- 18.6%, p = NS), heart rate, or O(2) pulse at peak exercise. In contrast, ventilatory abnormalities (VE/VCO(2)) improved considerably (44.4 +/- 10.9 to 33.3 +/- 5.5, p <or= 0.001).
  
  
  CONCLUSIONS
  Fontan fenestration closure does not significantly improve peak VO(2). However, ventilatory abnormalities improve considerably.
authors.affiliation: Department of Cardiology, Children's Hospital-Boston, Boston, Massachusetts, USA. Jeffery.meadows@ucsf.edu
authors.forename: Jeffery
authors.initials: J
authors.lastname: Meadows
authors.forename: Peter
authors.initials: P
authors.lastname: Lang
authors.forename: Gerald
authors.initials: G
authors.lastname: Marx
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rhodes
mesh_terms: D000293:Adolescent; D000328:Adult; D006328:Cardiac Catheterization; D002648:Child; D002675:Child, Preschool; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D018729:Fontan Procedure / Q000379:methods*; D006330:Heart Defects, Congenital / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology; D011446:Prospective Studies; D012123:Pulmonary Ventilation / Q000502:physiology*; D016896:Treatment Outcome