title: Effects of increasing particle size of low-density lipoprotein on restenosis after coronary stent implantation.
abstract: BACKGROUND
  Small dense low-density lipoprotein (LDL) has emerged as an important risk factor in coronary atherosclerosis and vascular inflammation, which is related to neointimal hyperplasia. Therefore, the aim of the present study was to investigate whether changes in LDL particle size are related to in-stent restenosis (ISR).
  
  
  RESULTS
  The LDL subfraction and lipid profiles were measured in 274 patients (412 stents) at both baseline and follow-up coronary angiography (CAG). The incidence of ISR (80 lesions, 19.4%) was lower in the patients with increased LDL particle size than in those with no change or decrease (14.2% vs 25.8%, p=0.004). Logistic multivariate analysis revealed that stent length (>or=24 mm) (odds ratio (OR) =1.913, p=0.027), post minimal luminal diameter (>3 mm) (OR =0.528, p=0.028), acute coronary syndrome (OR =2.294, p=0.005), decrease in high-density lipoprotein-cholesterol (OR =1.028, p=0.047) and increase in LDL particle size (OR =0.528, p=0.031) were independent predictors for ISR.
  
  
  CONCLUSIONS
  In the present study, an increase in the LDL particle size between baseline and follow-up CAG was associated with reduced incidence of ISR. Therefore, modification of LDL particle size may have a beneficial effect on the risk of ISR.
authors.affiliation: Division of Cardiology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jung-Sun
authors.initials: JS
authors.lastname: Kim
authors.forename: Myung-Hyun
authors.initials: MH
authors.lastname: Kim
authors.forename: Byoung Kwon
authors.initials: BK
authors.lastname: Lee
authors.forename: Se-Joong
authors.initials: SJ
authors.lastname: Rim
authors.forename: Pil-Ki
authors.initials: PK
authors.lastname: Min
authors.forename: Se-Jung
authors.initials: SJ
authors.lastname: Yoon
authors.forename: Jeong-Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Ji-Hyuck
authors.initials: JH
authors.lastname: Rhee
authors.forename: Young Won
authors.initials: YW
authors.lastname: Yoon
authors.forename: Bum Kee
authors.initials: BK
authors.lastname: Hong
authors.forename: Hyuck Moon
authors.initials: HM
authors.lastname: Kwon
authors.forename: Changsoo
authors.initials: C
authors.lastname: Kim
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010316:Particle Size; D011237:Predictive Value of Tests; D012307:Risk Factors; D015607:Stents
chemical_list: D008077:Lipoproteins, LDL