title: Mid-infrared reflectivity of experimental atheromas.
abstract: We report that the pathologic components present within the atheromatous plaques of ApoE knock-out mice can reflect significant amounts of mid-infrared (mid-IR) light. Furthermore, the reflected light spectra contained the unique signatures of a variety of biologic features including those found in unstable or "vulnerable" plaque. This discovery may represent a unique opportunity to develop a new intravascular diagnostic modality that can detect and characterize sites of atherosclerosis.
authors.affiliation: University of California, Berkeley, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. hyholman@lbl.gov
authors.forename: Hoi-Ying N
authors.initials: HY
authors.lastname: Holman
authors.forename: Kathy A
authors.initials: KA
authors.lastname: Bjornstad
authors.forename: Michael C
authors.initials: MC
authors.lastname: Martin
authors.forename: Wayne R
authors.initials: WR
authors.lastname: McKinney
authors.forename: Eleanor A
authors.initials: EA
authors.lastname: Blakely
authors.forename: Francis G
authors.initials: FG
authors.lastname: Blankenberg
mesh_terms: D000818:Animals; D001018:Aortic Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism; D050197:Atherosclerosis / Q000175:diagnosis* / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D007259:Infrared Rays; D051379:Mice; D018345:Mice, Knockout; D010783:Photometry / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D001057:Apolipoproteins E