Studies of macrophage immuno-modulating activity of polysaccharides isolated from Paecilomyces tenuipes.
The objective of this study was to evaluate the immunomodulatory effects of the Paecilomyces sinensis polysaccharides (PtP) on the activity of macrophages and human monocytes. A water-soluble polysaccharide, with estimated molecular weight of 2.04x10(4) Da, was isolated from P. sinensis. The results indicate that PtP can increase the activity of LDH and ACP in AMphi and PMphi of rats and human mononuclear cells, and enhance the pinocytic activity of macrophages and TNF-alpha production by human peripheral blood mononuclear cells (PBMC), suggesting that PtP had potent immunomodulatory properties and could be explored as a novel potential immunostimulants for the food and pharmaceutical purpose.
Chen
Xiaoming
X
Institute of Cellular and Molecular Medicine, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine, Wenzhou Medical College, Wenzhou 325035, PR China.
Lu
Jianxin
J
Zhang
Yangde
Y
He
Jiantai
J
Guo
Xunzhi
X
Tian
Gengyuan
G
Jin
Liqin
L
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D006801:Humans; D007155:Immunologic Factors / Q000302:isolation & purification* / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology*; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000201:enzymology / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000201:enzymology / Q000276:immunology; D009000:Monocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D010143:Paecilomyces / Q000737:chemistry*; D010873:Pinocytosis / Q000187:drug effects; D011134:Polysaccharides / Q000302:isolation & purification* / Q000494:pharmacology*; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D007155:Immunologic Factors; D011134:Polysaccharides; D014409:Tumor Necrosis Factor-alpha; D007770:L-Lactate Dehydrogenase; D000135:Acid Phosphatase