title: Translational regulation by non-protein-coding RNAs: different targets, common themes.
abstract: There are several classes of small non-protein-coding RNA (npcRNA) that play important roles in cellular metabolism including mRNA decoding, RNA processing and mRNA stability. Indeed, altered expression of some of these npcRNAs has been associated with cancer, neurodegenerative diseases such as Alzheimer's disease, as well as various types of mental retardation and psychiatric disorders. The basis of this correlation is currently not understood. However, recent studies have begun to shed light on one of the mechanism(s) by which these RNAs exert their effects, namely, translational control. These data provide hope that rational treatments for these varied disorders may be in sight. Here, we review this new body of work.
authors.affiliation: Department of Molecular Biology, Laboratory of Biochemical Molecular Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.
authors.forename: Wen
authors.initials: W
authors.lastname: Xie
authors.forename: W
authors.initials: W
authors.lastname: Ted Brown
authors.forename: Robert B
authors.initials: RB
authors.lastname: Denman
mesh_terms: D020087:Alu Elements; D000818:Animals; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D010443:Peptide Chain Termination, Translational / Q000235:genetics*; D020733:RNA, Small Cytoplasmic / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000378:metabolism
chemical_list: C117734:BC1 RNA; D035683:MicroRNAs; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins