title: Momilactone B, an allelochemical of rice hulls, induces apoptosis on human lymphoma cells (Jurkat) in a micromolar concentration.
abstract: Although momilactone B has been studied as an allelochemical of rice (Oryza sativa L.), to date we have no report showing the effect of momilactone B on mammalian cells. This study was undertaken to examine whether this allelochemical has anticancer activity on cancer cells. We show here that momilactone B at micromolar doses has antitumor efficacy by inducing apoptosis in several blood cancer cells including human leukemic T cells. In addition, our study elucidated that anticancer activity of momilactone B on human leukemic T cells resulted from the induction of apoptosis via caspase and mitochondria. From these results, momilactone B can be considered as a novel therapeutic strategy for human leukemic T cells from its direct apoptosis-inducing activity.
authors.affiliation: Dong-A University College of Medicine and Medical Science Research Center, Busan, South Korea.
authors.forename: Seung C
authors.initials: SC
authors.lastname: Lee
authors.forename: Ill-Min
authors.initials: IM
authors.lastname: Chung
authors.forename: Yeong J
authors.initials: YJ
authors.lastname: Jin
authors.forename: Yeon S
authors.initials: YS
authors.lastname: Song
authors.forename: Su Y
authors.initials: SY
authors.lastname: Seo
authors.forename: Bong S
authors.initials: BS
authors.lastname: Park
authors.forename: Kwang H
authors.initials: KH
authors.lastname: Cho
authors.forename: Ki S
authors.initials: KS
authors.lastname: Yoo
authors.forename: Tae-Hyun
authors.initials: TH
authors.lastname: Kim
authors.forename: Su-Bog
authors.initials: SB
authors.lastname: Yee
authors.forename: Yoe-Sik
authors.initials: YS
authors.lastname: Bae
authors.forename: Young H
authors.initials: YH
authors.lastname: Yoo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000502:physiology; D002452:Cell Count; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D019169:Jurkat Cells; D007783:Lactones / Q000008:administration & dosage*; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D012275:Oryza / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*; D013601:T-Lymphocytes / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D007783:Lactones; C477203:momilactone B; D053148:Caspase 3