[Post-prandial hyperglycemia in type 2 diabetes patients].
OBJECTIVE
Through the analysis of a group of type 2 diabetes patients, the aims of this study are: to evaluate through CGMS (continuous glucose monitoring system) the post-prandial subcutaneous glucose excursions; to analyze the correlations between subcutaneous glucose and capillary glycemia with HbA1c and to evaluate the effectiveness, safety and broad-mindedness of the CGMS.


METHODS
Forty type 2 diabetes patients were analyzed, with HbA1c until 7.3%, in use of oral agents and within less than a ten-year diagnosis. They were submitted to CGMS for 72 h, whose data were compared with HbA1c and capillary glycemia.


RESULTS
The average subcutaneous glucose excursion at breakfast was statistically bigger than at dinner (95%CI -24.96 a -1.66). The subcutaneous glucose excursion/meal carbohydrates content ratio was statistically bigger at breakfast than at other meals (p 0.001). There was no correlation between the levels of subcutaneous glucose and capillary glycemia with HbA1c. There were no complications using CGMS.


CONCLUSIONS
The subcutaneous glucose excursions were predominant at breakfast. There were no correlations between HbA1c and glycemic control parameters. CGMS showed itself efficient, secure and well tolerated in this group of patients.
Cruzes
André Luiz
AL
Departamento de Endocrinologia, Associação de Diabetes Juvenil, Birigui, SP, Brasil. alcruzes@uol.com.br
Bosco
Cláudia Elaine T
CE
Pandini
Elaine V
EV
Hernandez
Miguel A M
MA
Silva
Regina C Q da
RC
D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring / Q000009:adverse effects / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D011446:Prospective Studies; D015203:Reproducibility of Results
D001786:Blood Glucose; D006442:Glycated Hemoglobin