title: Immobilization of derivatized dextran nanoparticles on konjac glucomannan/chitosan film as a novel wound dressing.
abstract: The aim of this study was to prepare konjac glucomannan (KGM)/chitosan (CS) film containing glycidyl methacrylate derivatized dextran (dex-GMA)/acrylic acid(AAc) nanoparticles loaded with antibacterial agent. In this study, An optimized procedure chosen from three methods was used to prepare Erythromycin (EM)-loaded poly(dex-GMA/AAc) nanoparticles and obtained nanoparticles ranged from 50-200 nm. Film was found to have equilibrium water content (EWC) 99.3% which could prevent exudates on wound bed from accumulating and also have excellent water adsorption 2362.3 +/- 55.2%; the water vapor transmission rate (WVTR) was 2335 +/- 36 gm(-2) day(-1) and evaporative water loss from the film (EWL) was approximately 10% after 1 h and within 6 h it increased to 90%. Drug release of film containing nanoparticles or absent was determined, within 22 h accumulative release was 40.3%, 72.5% respectively. In conclusion, KGM/CS film containing nanoparticles could not only maintain a moist environment over wound bed in moderate to heavily exuding wound but also provide a continuous and sustained release of the antibacterial agent on the wound surface, which could be potential wound dressing.
authors.affiliation: School of Pharmacy, Fourth Military Medical University, Xi'an, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Chun-Hu
authors.initials: CH
authors.lastname: Gu
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Fan
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Qian
authors.initials: Q
authors.lastname: Yang
mesh_terms: D001424:Bacterial Infections / Q000517:prevention & control; D001458:Bandages; D048271:Chitosan / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry; D004917:Erythromycin / Q000008:administration & dosage*; D008351:Mannans / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D003911:Dextrans; D004852:Epoxy Compounds; D008351:Mannans; D008689:Methacrylates; D014867:Water; C022901:(1-6)-alpha-glucomannan; D004917:Erythromycin; D048271:Chitosan; C007870:glycidyl methacrylate