Acute dystonia in a young schizophrenic patient associated with ingestion of a cloperastine containing cough syrup.
Acute dystonic reactions are usually observed after exposure to drugs with antidopaminergic actions. We report on one patient with acute dystonia associated with ingestion of a cloperastine containing syrup, who suffered from schizophrenia but had been neuroleptic-free for 6months. Cloperastine has antihistaminic properties. We suggest that antihistaminic agents may induce acute dystonia by altering the balance between dopamine and acetylcholine in the striatum.
Linazasoro
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Centro de Neurologia y Neurocirugia Funcional, Clinica Quirón, Parque Alcolea s/n, 20012 San Sebastián, Guipúzcoa, Spain.
Garmendia
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MT
Lizaso
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