Assignment of isochores for all completely sequenced vertebrate genomes using a consensus.
We show that although the currently available isochore mapping methods agree on the isochore classification of about two-thirds of the human DNA, they produce significantly different results with regard to the location of isochore boundaries and isochore length distribution. We present a new consensus isochore assignment method based on majority voting and provide IsoBase, a comprehensive on-line database of isochore maps for all completely sequenced vertebrate genomes.
Schmidt
Thorsten
T
Department of Genome-Oriented Bioinformatics, Wissenschaftszentrum Weihenstephan, Technische Universität München, D-85350 Freising, Germany.
Frishman
Dmitrij
D
D000818:Animals; D030541:Databases, Genetic; D005821:Genetic Techniques; D006801:Humans; D032085:Isochores / Q000235:genetics*
D032085:Isochores