title: Structure, antimicrobial activity and DNA-binding properties of the cobalt(II)-sparfloxacin complex.
abstract: The neutral mononuclear cobalt(II) complex with sparfloxacin has been prepared and characterized with physicochemical, spectroscopic and electrochemical techniques, and molecular mechanics calculations. The interaction of the complex with calf-thymus DNA has been investigated with UV spectroscopy, cyclic voltammetry, and competitive studies with ethidium bromide. The antimicrobial activity of the complex has been tested against three microorganisms.
authors.affiliation: Institute of Physical Chemistry, NCSR Demokritos, GR-15310 Aghia Paraskevi Attikis, Greece.
authors.forename: Eleni K
authors.initials: EK
authors.lastname: Efthimiadou
authors.forename: Alexandra
authors.initials: A
authors.lastname: Karaliota
authors.forename: George
authors.initials: G
authors.lastname: Psomas
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002417:Cattle; D003035:Cobalt / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D015195:Drug Design; D004996:Ethidium / Q000494:pharmacology; D024841:Fluoroquinolones / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D008956:Models, Chemical; D008968:Molecular Conformation; D011485:Protein Binding; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D003035:Cobalt; D004247:DNA; C427203:calf thymus DNA; D004996:Ethidium; C061363:sparfloxacin