title: Synthesis, analgesic, anti-inflammatory and antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing thiazolotriazoles.
abstract: A series of 2,4-dichloro-5-fluorophenyl containing thiazolotriazoles were synthesized starting from 3-(2,4-dichloro-5-fluorophenyl)-4H-1,2,4-triazole-3-thiol. The newly synthesized compounds were characterized by IR, 1H NMR, mass and elemental analysis. Some of the synthesized compounds were tested for their anti-inflammatory, analgesic and antimicrobial activities. Compounds 8c, 8d and 8h exhibited excellent anti-inflammatory activity whereas compounds 8d, 8e and 8h showed excellent analgesic activity. Compounds 8a, 8c-e, and 8h exhibited good antibacterial activity and compounds 8c, 8e and 8h showed good antifungal activity.
authors.affiliation: Department of Chemistry, Mangalore University, Mangalagangothri 574199, India. refiyeyanardag@yahoo.com
authors.forename: Mari Sithambaram
authors.initials: MS
authors.lastname: Karthikeyan
mesh_terms: D000700:Analgesics / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013844:Thiazoles; D014230:Triazoles