title: Efficacy of prokinetic agents in improving bowel preparation for colonoscopy.
abstract: OBJECTIVE
  Colonoscopy plays an important role in the diagnosis and treatment of gastrointestinal illness in both Western countries and Japan. However, preparative bowel cleansing for colonoscopy is frequently troublesome for elderly and/or constipated patients, since they must drink larger volumes of lavage solution for adequate cleansing. We investigated the use of prokinetic agents for improving the efficacy and tolerability of bowel cleansing prior to colonoscopy.
  
  
  METHODS
  613 patients were divided into two groups according to oral lavage solution used (polyethylene glycol or magnesium citrate), and were further randomized to receive either vehicle (100 ml water) alone, vehicle with 5 mg mosapride citrate, or vehicle with 50 mg itopride hydrochloride 30 min before administration of lavage solution. Experimental parameters included bowel cleansing quality, times to first defecation and completion of bowel cleansing, and incidence of uncomfortable abdominal symptoms during colonoscopy preparation.
  
  
  RESULTS
  Administration of mosapride citrate or itopride hydrochloride prior to oral lavage solution did not significantly improve bowel cleansing quality. However, statistically significantly fewer uncomfortable abdominal symptoms were found in patients who received mosapride citrate or itopride hydrochloride versus vehicle alone.
  
  
  CONCLUSIONS
  Prokinetic agents effectively decreased the incidence of uncomfortable abdominal symptoms experienced during colonoscopy preparation.
authors.affiliation: Department of Gastroenterology and Hepatology, Shimane University, School of Medicine, Izumo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Mishima
authors.forename: Yuji
authors.initials: Y
authors.lastname: Amano
authors.forename: Koichi
authors.initials: K
authors.lastname: Okita
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Moriyama
authors.forename: Norihisa
authors.initials: N
authors.lastname: Ishimura
authors.forename: Kenji
authors.initials: K
authors.lastname: Furuta
authors.forename: Shunji
authors.initials: S
authors.lastname: Ishihara
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Adachi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita
mesh_terms: D000368:Aged; D000880:Anthraquinones; D001549:Benzamides / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000494:pharmacology*; D002400:Cathartics / Q000494:pharmacology*; D003113:Colonoscopy / Q000379:methods*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology; D012676:Senna Extract; D000081226:Sennosides; D007507:Therapeutic Irrigation / Q000379:methods*
chemical_list: D000880:Anthraquinones; D001549:Benzamides; D001593:Benzyl Compounds; D002400:Cathartics; D005765:Gastrointestinal Agents; D009025:Morpholines; D000081226:Sennosides; D011092:Polyethylene Glycols; D012676:Senna Extract; C102254:itopride; C062720:mosapride