[Applications of 1H nuclear magnetic resonance spectroscopy and nuclear magnetic resonance-based metabonomics in tumour studies].
1H nuclear magnetic resonance (1H NMR) spectroscopy has found widespread applications in tumour studies. Several complementary NMR techniques have provided valuable information concerning tumours, including in vivo localized 1H NMR spectroscopy, ex vivo high-resolution 1H NMR spectroscopy of extracts of intact tissue biopsy samples, high-resolution magic angle spinning 1H NMR spectroscopy of intact tissue biopsy samples, and in vitro high-resolution 1H NMR spectroscopy of body fluids. On the basis of the combination of NMR measurements with multivariate data analysis, 1H NMR-based metabonomics has become a promisingly novel approach in the studies of tumour early diagnosis, processes and prognosis estimate.
Gao
Hong-Chang
HC
Analytical Chemistry Laboratory, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Lin
Dong-Hai
DH
D001706:Biopsy; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D055442:Metabolome; D009369:Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000378:metabolism