On-line monitoring of hybridoma cell growth using a laser turbidity sensor.
A high-sensitivity turbidity probe was used for on-line monitoring of the cell concentration in batch hybridoma cultivation. Good correlation between off-line cell counts and the linearized sensor signal was found. The quality of the signal was sufficiently high to provide for on-line estimation of the specific growth rate using an efficient filtering procedure. These positive results suggest that such laser turbidity sensors will facilitate development of systems for on-line monitoring and control of animal cell cultivations.
Konstantinov
K B
KB
ICBiotech, Faculty of Engineering, Osaka University, Suita shi, Osaka 565, Japan.
Pambayun
R
R
Matanguihan
R
R
Yoshida
T
T
Perusicn
C M
CM
Hu
W S
WS