[Meta-analysis of association between pentachlorophenol exposure and cancer risk].
OBJECTIVE
The epidemiological data based on the exposure of pentachlorophenol (PCP) and cancer incidence and mortality were analyzed to study the relationship between PCP exposure and cancer risk.


METHODS
According to the online search of relevant literatures, Poisson regression was used to analyze mortality rates for major cancer sites and fixed-effect model was employed to assess cancer SMR. The dose-response relationship between PCP exposure and cancer risk was also analyzed.


RESULTS
Major cancer mortality rates of exposure populations researched in American and Canadian studies were approximate to or lower than national male cancer mortality rates respectively. The incidence rate of colorectal cancer in occupational exposure population was over 16.4 times in comparison with the population exposed from to drinking water and food. The pooled SMR value of kidney cancer was 1.34 (95% CI 1.02-1.77). The pooled RR for major cancer mortality increased with the rise of PCP exposure level.


CONCLUSIONS
A potential dose-response relationship between PCP exposure and cancer risk could exist. In comparison with to the population to exposed from the drinking water and food, the risk of colorectal cancer in occupational exposure population was higher. PCP may be one of the risk factors of the kidney cancer in occupational exposure population.
Zheng
Weiwei
W
Key Laboratory of the Public Health and Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.
Zhou
Ying
Y
Qu
Weidong
W
Zhang
Hao
H
et al
D002170:Canada / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000401:mortality; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000401:mortality; D009369:Neoplasms / Q000453:epidemiology* / Q000401:mortality; D010416:Pentachlorophenol / Q000633:toxicity*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
D010416:Pentachlorophenol