title: Unilateral spiny hyperkeratosis: case report and review of the literature.
abstract: We describe the first case of unilateral spiny hyperkeratosis (SH) of the left hand, review the literature and discuss possible patho- mechanisms. SH can be sporadic or familial, often appearing in healthy individuals. However, there is an association with various malignancies in a significant number of the sporadic cases. Although there is no satisfactory explanation of this association, we agree with previous authors that a patient with SH appearing in adult life should be evaluated and followed for the presence of malignancy. Other patients with SH may suffer from a variety of nonmalignant diseases, which may be coincidental or causally related. SH is not a premalignant lesion of the skin and should not be confused with porokeratosis which has a malignant potential. Except for excision of individual lesions, there is no permanent cure.
authors.affiliation: Department of Dermatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Baruch
authors.initials: B
authors.lastname: Mevorah
authors.forename: Andrea
authors.initials: A
authors.lastname: Gat
authors.forename: Haim
authors.initials: H
authors.lastname: Golan
authors.forename: Sarah
authors.initials: S
authors.lastname: Brenner
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D006229:Hand Dermatoses / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007645:Keratoderma, Palmoplantar / Q000175:diagnosis / Q000473:pathology*; D007642:Keratosis / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D018570:Risk Assessment; D016312:Treatment Refusal