Replication of association between ELAVL4 and Parkinson disease: the GenePD study.
Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. In the current study we genotyped three single nucleotide polymorphisms in ELAVL4 in a Caucasian study sample consisting of 712 PD patients and 312 unrelated controls from the GenePD study. The minor allele of rs967582 was associated with increased risk of PD (odds ratio = 1.46, nominal P value = 0.011) in the GenePD population. The minor allele of rs967582 was also the risk allele for PD affection or earlier onset age in the previously studied populations. This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene.
DeStefano
Anita L
AL
Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Crosstown Center, 3rd floor, Boston, MA 02118, USA. adestef@bu.edu
Latourelle
Jeanne
J
Lew
Mark F
MF
Suchowersky
Oksana
O
Klein
Christine
C
Golbe
Lawrence I
LI
Mark
Margery H
MH
Growdon
John H
JH
Wooten
G Fredrick
GF
Watts
Ray
R
Guttman
Mark
M
Racette
Brad A
BA
Perlmutter
Joel S
JS
Marlor
Lynn
L
Shill
Holly A
HA
Singer
Carlos
C
Goldwurm
Stefano
S
Pezzoli
Gianni
G
Saint-Hilaire
Marie H
MH
Hendricks
Audrey E
AE
Gower
Adam
A
Williamson
Sally
S
Nagle
Michael W
MW
Wilk
Jemma B
JB
Massood
Tiffany
T
Huskey
Karen W
KW
Baker
Kenneth B
KB
Itin
Ilia
I
Litvan
Irene
I
Nicholson
Garth
G
Corbett
Alastair
A
Nance
Martha
M
Drasby
Edward
E
Isaacson
Stuart
S
Burn
David J
DJ
Chinnery
Patrick F
PF
Pramstaller
Peter P
PP
Al-Hinti
Jomana
J
Moller
Anette T
AT
Ostergaard
Karen
K
Sherman
Scott J
SJ
Roxburgh
Richard
R
Snow
Barry
B
Slevin
John T
JT
Cambi
Franca
F
Gusella
James F
JF
Myers
Richard H
RH
D017668:Age of Onset; D000368:Aged; D015331:Cohort Studies; D030541:Databases, Genetic; D051959:ELAV Proteins / Q000235:genetics* / Q000502:physiology; D000067779:ELAV-Like Protein 4; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic
D051959:ELAV Proteins; D000067779:ELAV-Like Protein 4; C498010:ELAVL4 protein, human