title: Evaluation of the guidelines for management of pancreatic branch-duct intraductal papillary mucinous neoplasm.
abstract: OBJECTIVE
  The 2006 Sendai Consensus Guidelines recommend surgical resection for all suspected branch-duct intraductal papillary mucinous neoplasm (BD-IPMN) greater than 3 cm irrespective of symptoms, and those less than 3 cm with worrisome features. We aimed to evaluate the surgical characteristics of these guidelines retrospectively in pathologically confirmed cases of BD-IPMN.
  
  
  METHODS
  IPMNs resected at our institution (1995-2006) were classified as main-duct predominant or branch-duct (BD) predominant based on preoperative imaging and postoperative histology. Resected BD-IPMNs were classified histologically: low risk (adenoma, borderline) and high risk (carcinoma in situ or invasive cancer). Clinical data (presence of symptoms, mural nodule, dilated pancreatic duct, and cyst size) were correlated with pathology.
  
  
  RESULTS
  Between 1995 and 2006, there were 204 patients who underwent surgical resection of pancreatic cysts. Sixty-one patients had IPMN including 31 with BD-IPMN. A total of 74.2% (23 of 31) of BD-IPMNs would have been recommended for surgical resection including 69.2% (18 of 26) of low-risk lesions and 100% (5 of 5) of high-risk lesions. All 8 cases of BD-IPMN that would have been recommended for nonsurgical management were low-risk lesions. The positive predictive value of the guidelines is 21.7% (95% confidence interval, 9.7%-41.9%). The negative predictive value is 100% (95% confidence interval, 67.6%-100.0%). Between 2000 and 2007, 351 patients with likely BD-IPMN were evaluated but not resected.
  
  
  CONCLUSIONS
  Implementation of the Consensus Guidelines to our single-institution, referral-based, surgical BD-IPMN population would have recommended resection of all histologically high-risk lesions. All lesions recommended for nonsurgical management were histologically low-risk lesions. For presumed BD-IPMNs less than 3 cm, the application of the Consensus Guidelines may reduce the resection rate for low-risk lesions.
authors.affiliation: Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California 951693, USA.
authors.forename: Raymond S
authors.initials: RS
authors.lastname: Tang
authors.forename: Benjamin
authors.initials: B
authors.lastname: Weinberg
authors.forename: David W
authors.initials: DW
authors.lastname: Dawson
authors.forename: Howard
authors.initials: H
authors.lastname: Reber
authors.forename: Oscar J
authors.initials: OJ
authors.lastname: Hines
authors.forename: James S
authors.initials: JS
authors.lastname: Tomlinson
authors.forename: Vinika
authors.initials: V
authors.lastname: Chaudhari
authors.forename: Steven
authors.initials: S
authors.lastname: Raman
authors.forename: James J
authors.initials: JJ
authors.lastname: Farrell
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D021441:Carcinoma, Pancreatic Ductal / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D003560:Cysts / Q000473:pathology; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D011237:Predictive Value of Tests; D011860:Radiography, Abdominal; D012189:Retrospective Studies; D012720:Severity of Illness Index