title: A clinical trial examining the effect of increased total CRM(197) carrier protein dose on the antibody response to Haemophilus influenzae type b CRM(197) conjugate vaccine.
abstract: CRM(197) is a carrier protein in certain conjugate vaccines. When multiple conjugate vaccines with the same carrier protein are administered simultaneously, reduced response to vaccines and/or antigens related to the carrier protein may occur. This study examined responses of infants who, in addition to diphtheria toxoid/tetanus toxoid/acellular pertussis vaccine (DTaP) received either diphtheria CRM(197)-based Haemophilus influenzae type b conjugate vaccine (HbOC) or HbOC and a diphtheria CRM(197)-based combination 9-valent pneumococcal conjugate vaccine/meningococcal group C conjugate vaccine. Administration of conjugate vaccines with CRM(197) carrier protein load >50 microg did not reduce response to CRM(197) conjugate vaccines or immunogenicity to immunologically cross-reactive diphtheria toxoid.
authors.affiliation: Vilnius University, Vilnius, Lithuania. vytautas.usonis@mf.vu.lt
authors.forename: Vytautas
authors.initials: V
authors.lastname: Usonis
authors.forename: Vytautas
authors.initials: V
authors.lastname: Bakasenas
authors.forename: Stephen
authors.initials: S
authors.lastname: Lockhart
authors.forename: Sherryl
authors.initials: S
authors.lastname: Baker
authors.forename: William
authors.initials: W
authors.lastname: Gruber
authors.forename: France
authors.initials: F
authors.lastname: Laudat
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D001426:Bacterial Proteins / Q000009:adverse effects* / Q000276:immunology*; D004168:Diphtheria Toxoid / Q000008:administration & dosage; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage; D004347:Drug Interactions; D005260:Female; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D022401:Meningococcal Vaccines / Q000008:administration & dosage
chemical_list: D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D004168:Diphtheria Toxoid; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D018073:Haemophilus Vaccines; C052180:Haemophilus influenzae type b-polysaccharide vaccine-diphtheria toxoid conjugate; D022401:Meningococcal Vaccines; C410218:serogroup C meningococcal conjugate vaccine; C061963:HibTITER protein, Haemophilus influenzae