title: Studies on in vitro biostability and blood compatibility of polyurethane potting compound based on aromatic polymeric MDI for extracorporeal devices.
abstract: Polyurethane potting compound based on aromatic isocyanurate of polymeric MDI, poly propylene glycol (PPG400) and trimethylol propane (TMP) has significant favourable properties, good pot life and setting characteristics. The cured potting compound of this formulation has appreciable thermal stability and mechanical properties. In vitro biostability of cured potting compound has been found to be excellent without any significant degradation in simulated physiological media and chemical environment. Studies on blood-material interaction and cytotoxicity reveal in vitro blood compatibility and compatibility with cells of this potting compound.
authors.affiliation: Polymer Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695012, India.
authors.forename: V K
authors.initials: VK
authors.lastname: Hridya
authors.forename: M
authors.initials: M
authors.lastname: Jayabalan
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001673:Biodegradation, Environmental; D001769:Blood / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004355:Drug Stability; D004864:Equipment and Supplies; D005347:Fibroblasts / Q000187:drug effects / Q000502:physiology; D006801:Humans; D017953:Isocyanates / Q000737:chemistry* / Q000494:pharmacology; D008422:Materials Testing; D051379:Mice; D011140:Polyurethanes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D001672:Biocompatible Materials; D017953:Isocyanates; D011140:Polyurethanes; C087867:polymeric 4,4'-diphenylmethane diisocyanate