Effect of opium addiction on diabetes.
BACKGROUND
Type 2 diabetes is a common disorder that is recognized as a major health problem in Iran. Diabetes is a major cause of morbidity, mortality, and economic burden to the society. Some people believe that smoking opium can reduce serum glucose and lipids in diabetes mellitus. This study was designed to compare blood glucose and lipids in opium addicts with non-addicts among patients with type 2 diabetes.


METHODS
In this case, control study subjects were chosen from type 2 diabetic patients. Twenty-three males with type 2 diabetes and addicted to opium were selected as the case group, and 46 patients with no addiction to opioid drugs were chosen as control group. Blood Sugar (BS), glycated hemoglobin (HbA1C), lipids and microalbumin in urine were measured in two groups.


RESULTS
Our results showed that the mean FBS and 2-hour post prandial were significantly different between two groups. (P = .04). No significant difference was observed in HbA1C, triglyceride, total cholesterol, LDL, and HDL between the two groups (P > .05).


CONCLUSIONS
Our finding showed that while opium might decrease blood glucose temporarily, it had no clear and long-lasting effects on blood glucose, as it had no significant effect on HbA1c.
Azod
Laila
L
Yazd Diabetes Research Center, Shahid Sadougdi University of Medical Science, Yazd, Iran.
Rashidi
Maryam
M
Afkhami-Ardekani
Mohammad
M
Kiani
Golchehr
G
Khoshkam
Fariba
F
D000418:Albumins / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002784:Cholesterol / Q000378:metabolism; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006442:Glycated Hemoglobin / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009294:Narcotics / Q000009:adverse effects*; D009293:Opioid-Related Disorders / Q000453:epidemiology* / Q000209:etiology*; D009892:Opium / Q000009:adverse effects*; D019518:Postprandial Period; D014280:Triglycerides / Q000378:metabolism
D000418:Albumins; D001786:Blood Glucose; D002784:Cholesterol; D006442:Glycated Hemoglobin; D009294:Narcotics; D009892:Opium; D014280:Triglycerides