title: Weekly measurements accurately represent trends in resting energy expenditure in children undergoing hematopoietic stem cell transplantation.
abstract: BACKGROUND
  Resting energy expenditure (REE) measurements are optimal for accurate assessment of energy requirements and precise provision of parenteral nutrients. We previously observed significant reduction in REE during a 4-week period in children undergoing hematopoietic stem cell transplantation (HSCT). The goal of this study was to determine if weekly REE measurements could accurately represent changes in REE in the peritransplant period compared with a more frequent standard of daily measurements.
  
  
  METHODS
  Data are presented from a previously described cohort of 37 children undergoing HSCT. We performed weekly indirect calorimetry on 25 patients; of those 25, we performed daily measurements on a convenience sample of 5 children. The time course of REE was analyzed in each sample by repeated measures regression.
  
  
  RESULTS
  The REE trend of the 20 weekly participants was similar to that of the 5 daily participants, reaching about 80% of predicted REE at 4 weeks posttransplant, with an average decline of 3.4% per week during 4 weeks.
  
  
  CONCLUSIONS
  The results suggest that weekly REE measurements accurately characterize REE changes 4 weeks after HSCT compared with daily measurements. Characterization of these trends using weekly measurements may help guide clinical and nutrition care of these patients.
authors.affiliation: Children's Hospital Boston, Boston, MA 02115, USA.
authors.forename: Debora
authors.initials: D
authors.lastname: Duro
authors.forename: Lori J
authors.initials: LJ
authors.lastname: Bechard
authors.forename: Henry A
authors.initials: HA
authors.lastname: Feldman
authors.forename: Arkady
authors.initials: A
authors.lastname: Klykov
authors.forename: Alice
authors.initials: A
authors.lastname: O'Leary
authors.forename: Eva C
authors.initials: EC
authors.lastname: Guinan
authors.forename: Christopher
authors.initials: C
authors.lastname: Duggan
mesh_terms: D000293:Adolescent; D000328:Adult; D001481:Basal Metabolism / Q000502:physiology*; D002153:Calorimetry, Indirect / Q000592:standards; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D008297:Male; D009751:Nutritional Requirements; D010288:Parenteral Nutrition / Q000379:methods*; D011184:Postoperative Period; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity