Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides.
Protein tyrosine phosphatases (PTPs) are cysteine-dependent enzymes that play a central role in cell signaling. Organic hydroperoxides cause thiol-reversible, oxidative inactivation of PTP1B in a manner that mirrors the endogenous signaling agent hydrogen peroxide.
Bhattacharya
Sanjib
S
Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211, USA.
Labutti
Jason N
JN
Seiner
Derrick R
DR
Gates
Kent S
KS
D003545:Cysteine / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010463:Peracetic Acid / Q000494:pharmacology; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D013438:Sulfhydryl Compounds; D006861:Hydrogen Peroxide; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D005978:Glutathione; D010463:Peracetic Acid; D003545:Cysteine