title: Lack of multiple copies of pfmdr1 gene in Papua New Guinea.
abstract: We describe here the results of an analysis of Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene copy number from 440 field isolates from Papua New Guinea. No multiple copies of the gene were found, which corresponds to the lack of usage of mefloquine. These data extend regional knowledge about the distribution of multidrug-resistant P. falciparum.
authors.affiliation: Swiss Tropical Institute, Socinstrasse 57, P.O. Box 4002 Basle, Switzerland.
authors.forename: Eva Maria
authors.initials: EM
authors.lastname: Hodel
authors.forename: Jutta
authors.initials: J
authors.lastname: Marfurt
authors.forename: Dania
authors.initials: D
authors.lastname: Müller
authors.forename: Anja
authors.initials: A
authors.lastname: Rippert
authors.forename: Steffen
authors.initials: S
authors.lastname: Borrmann
authors.forename: Ivo
authors.initials: I
authors.lastname: Müller
authors.forename: John C
authors.initials: JC
authors.lastname: Reeder
authors.forename: Peter
authors.initials: P
authors.lastname: Siba
authors.forename: Blaise
authors.initials: B
authors.lastname: Genton
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Beck
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D037621:Artemisinins / Q000627:therapeutic use; D000077332:Artesunate; D004351:Drug Resistance / Q000235:genetics; D019450:Genes, MDR / Q000235:genetics; D005838:Genotype; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000235:genetics*; D015767:Mefloquine / Q000627:therapeutic use; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics*; D010219:Papua New Guinea; D010963:Plasmodium falciparum / Q000187:drug effects / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D000077332:Artesunate; D015767:Mefloquine; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C513498:Mdr1 protein, Plasmodium falciparum