Neoplasms of urinary bladders of hamsters treated with 2-acetylaminofluorene and indole.
Tested in hamsters was the effect of neonatal treatment with 2-acetylaminofluorene (AAF) followed by prolonged feeding in combination with indole on the development of bladder tumors. Neonatal males and females were given intraperitoneal injections of AAF, 5 mg/100 g body weight, 3 times weekly until weaning. They were then fed a synthetic diet containing 0.06% AAF and 1.6% indole. The 26 hamsters surviving 10-12 months developed transitional cell carcinomas of the bladder, all but 2 of which were invasive. No hamsters had malignant tumors in the liver. Seven hamsters developed peliosis of the spleen.
Oyasu
R
R
Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA.
Sumie
H
H
Burg
H E
HE
D015073:2-Acetylaminofluorene / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D000831:Animals, Newborn; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced* / Q000473:pathology; D006224:Cricetinae; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced; D007211:Indoles / Q000008:administration & dosage / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D008297:Male; D008647:Mesocricetus; D009361:Neoplasm Invasiveness; D001743:Urinary Bladder / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens; D007211:Indoles; C100047:3-acetylaminofluorene; C030374:indole; D015073:2-Acetylaminofluorene