Monitoring the synthetic procedures of commercial drugs by 2H NMR spectroscopy: the case of ibuprofen and naproxen.
We determined the D/H isotope ratios of some ibuprofen and naproxen samples by (2)H NMR spectroscopy. Some of these values were found to be useful for collecting hints on the synthetic procedures employed to prepare these drugs. Site-specific isotope ratio analysis shows great potentials in the fight against patent infringement.
Acetti
Daniela
D
Dipartimento di Chimica, Materiali, Ingegneria Chimica, Politecnico di Milano, and Istituto CNR per la Chimica del Riconoscimento Molecolare, Via Mancinelli 7, Milano I-20131, Italy.
Brenna
Elisabetta
E
Fronza
Giovanni
G
Fuganti
Claudio
C
D003903:Deuterium / Q000032:analysis; D007052:Ibuprofen / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009288:Naproxen / Q000138:chemical synthesis*; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis
D004364:Pharmaceutical Preparations; D009288:Naproxen; D003903:Deuterium; D007052:Ibuprofen