title: Beyerane derivatives and a sesquiterpene dimer from Japanese Cypress (Chamaecyparis obtusa).
abstract: In the course of studies on biological active constituents from woody plants, we previously reported the isolation of many lignan derivatives as neurite outgrowth-promoting compounds from an ethyl acetate soluble fraction of Japanese Cypress (Chamaecyparis obtusa). Further chemical investigation on the residual parts of the ethyl acetate soluble fraction of a methanol extract of Japanese Cypress resulted in the isolation of four new beyerene type derivatives and a novel sesquiterpene dimer formed between cryptomeridiol and hinokiic acid. Their structures were elucidated as 18-O-(Z)-p-coumaroylbeyer-15-ene-18-ol (1), 18-O-(E)-p-coumaroylbeyer-15-ene-18-ol (2), 18-O-(E)-p-coumaroylbeyer-15-ene-11beta,18-diol (3), 18-O-(Z)-p-coumaroylbeyer-15-ene-11beta,18-diol (4) and ent-cryptomeridiol-4-yl-hinokiiate (5) by (1)H-NMR, (13)C-NMR, 2D-NMR, and HR-MS spectral analysis.
authors.affiliation: School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenhe Shenyang, PR China.
authors.forename: Hui Yuan
authors.initials: HY
authors.lastname: Gao
authors.forename: Li Jun
authors.initials: LJ
authors.lastname: Wu
authors.forename: Norio
authors.initials: N
authors.lastname: Muto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fuchino
authors.forename: Takahisa
authors.initials: T
authors.lastname: Nakane
authors.forename: Osamu
authors.initials: O
authors.lastname: Shirota
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Sano
authors.forename: Masanori
authors.initials: M
authors.lastname: Kuroyanagi
mesh_terms: D029780:Chamaecyparis / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D004224:Diterpenes; D012717:Sesquiterpenes