title: Impact of antiretroviral therapy on chemokine (C-C motif) receptor 5 expression in HIV patients followed for over 2 years.
abstract: Suppression of HIV replication using highly active antiretroviral therapy (HAART) might influence chemokine (C-C motif) receptor 5 expression on infected cells and therefore modulate the activity of chemokine (C-C motif) receptor 5 antagonists. Chemokine (C-C motif) receptor 5 expression was examined longitudinally in 26 HIV-infected adults who initiated HAART. Long-term suppression of plasma HIV-RNA did not significantly influence chemokine (C-C motif) receptor 5 expression on T lymphocytes. Therefore, the activity of chemokine (C-C motif) receptor 5 antagonists should not differ before and following HIV suppression on HAART.
authors.affiliation: Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain.
authors.forename: Verónica
authors.initials: V
authors.lastname: Briz
authors.forename: Eva
authors.initials: E
authors.lastname: Poveda
authors.forename: Mariola
authors.initials: M
authors.lastname: López
authors.forename: María Del Mar
authors.initials: Mdel M
authors.lastname: González
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Benito
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D019713:Receptors, CCR5 / Q000097:blood*
chemical_list: D019380:Anti-HIV Agents; D019713:Receptors, CCR5