Circulating adiponectin levels in patients with atrial fibrillation.
BACKGROUND
Atrial fibrillation (AF) characterized by atrial remodeling occurs with obesity-related conditions. Adiponectin, an adipose tissue-derived hormone exerts beneficial effects on ventricular remodeling, so in the present study the potential association between circulating adiponectin levels and atrial remodeling in patients with AF was investigated.


RESULTS
The levels of plasma adiponectin, serum carboxy-terminal telopeptide of collagen type I (CITP), as a collagen type I degradation marker, and serum type III procollagen-N-peptide (PIIINP), as a collagen type III synthesis marker, were measured in 304 consecutive patients (162 paroxysmal AF, 46 persistent AF, 96 paroxysmal supra-ventricular tachycardia [controls]). Plasma adiponectin levels were significantly higher in patients with persistent AF than in those with paroxysmal AF or the control patients (p<0.05). Serum CITP levels, but not serum PIIINP levels, were higher in patients with persistent AF compared with the paroxysmal AF and control patients (p<0.05). In addition, there was a positive correlation between adiponectin levels and CITP levels in patients with persistent AF (r=0.39, p<0.005).


CONCLUSIONS
High plasma adiponectin levels are associated with the presence of persistent AF, which is accompanied by increased CITP levels. Thus, measurement of plasma adiponectin could be useful for assessment of AF.
Shimano
Masayuki
M
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shibata
Rei
R
Tsuji
Yukiomi
Y
Kamiya
Hiromi
H
Uchikawa
Tomohiro
T
Harata
Shuji
S
Muto
Masahiro
M
Ouchi
Noriyuki
N
Inden
Yasuya
Y
Murohara
Toyoaki
T
D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood*; D024042:Collagen Type I / Q000097:blood / Q000378:metabolism; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood; D015995:Prevalence; D011347:Procollagen / Q000097:blood; D020257:Ventricular Remodeling / Q000502:physiology
C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C041876:procollagen Type III-N-terminal peptide