title: High-grade cervical disease in adolescents with HIV.
abstract: OBJECTIVE
  To estimate the risk of high-grade squamous intraepithelial lesions (HSIL) in adolescents with HIV.
  
  
  METHODS
  Review of cervical cytology and biopsy results from women aged 20 years and younger obtained within 3 years of enrollment in a prospective multicenter study.
  
  
  RESULTS
  At enrollment, none of 132 adolescent participants (45 HIV seropositive and 87 seronegative) had HSIL or cervical intraepithelial neoplasia grade 2 or 3 (CIN 2,3). Eight (7%) of 123 women with follow-up developed high-grade disease after a median of 2.6 years of observation. The incidence of HSIL/CIN 2,3 was 2.7/100 person-years (4.8/100 person-years in HIV seropositive and 1.6/100 person-years in HIV seronegative women; relative risk = 3.1; 95% CI = 0.76-12.74; p =.13). No cancers were found in adolescents during the study.
  
  
  CONCLUSIONS
  The low incidence of HSIL or CIN 2,3 in adolescents suggests that optimal management is careful observation rather than preventive treatment of low-grade abnormalities.
authors.affiliation: Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA. massadl@wudosis.wustl.edu
authors.forename: L Stewart
authors.initials: LS
authors.lastname: Massad
authors.forename: Charlesnika T
authors.initials: CT
authors.lastname: Evans
authors.forename: Gypsyamber
authors.initials: G
authors.lastname: D'Souza
authors.forename: Teresa
authors.initials: T
authors.lastname: Darragh
authors.forename: Howard
authors.initials: H
authors.lastname: Minkoff
authors.forename: Donna
authors.initials: D
authors.lastname: Henry
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Goparaju
authors.forename: Laila I
authors.initials: LI
authors.lastname: Muderspach
authors.forename: D Heather
authors.initials: DH
authors.lastname: Watts
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006679:HIV Seropositivity / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D015995:Prevalence; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology*