title: Bayesian joint mapping of quantitative trait loci for Gaussian and categorical characters in line crosses.
abstract: Methodology for joint mapping of quantitative trait loci (QTL) affecting continuous and binary characters in experimental crosses is presented. The procedure consists of a Bayesian Gaussian-threshold model implemented via Markov chain Monte Carlo, which bypasses bottlenecks due to high-dimensional integrals required in maximum likelihood approaches. The method handles multiple binary traits and multiple QTL. Modeling of ordered categorical traits is discussed as well. Features of the method are illustrated using simulated datasets representing a backcross design, and the data are analyzed using mixed-trait and single-trait models. The mixed-trait analysis provides greater detection power of a QTL than a single-trait analysis when the QTL affects two or more traits. The number of QTL inferred in the mixed-trait analysis does not pertain to a specific trait, but the roles of each QTL on specific traits can be assessed from estimates of its effects. The impacts of varying incidence level and sample size on the mixed-trait QTL mapping analysis are investigated as well.
authors.affiliation: Department of Dairy Science, University of Wisconsin, Madison, WI 53706, USA. nickwu@ansci.wisc.edu
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Wu
authors.forename: Daniel
authors.initials: D
authors.lastname: Gianola
authors.forename: Kent
authors.initials: K
authors.lastname: Weigel
mesh_terms: D001499:Bayes Theorem; D003433:Crosses, Genetic; D016013:Likelihood Functions; D040641:Quantitative Trait Loci / Q000235:genetics*