Dynamics of maternal morphogen gradients in Drosophila.
The first direct studies of morphogen gradients were done in the end of 1980s, in the early Drosophila embryo, which is patterned under the action of four maternally determined morphogens. Since the early studies of maternal morphogens were done with fixed embryos, they were viewed as relatively static signals. Several recent studies analyze dynamics of the anterior, dorsoventral, and terminal patterning signals. The results of these quantitative studies provide critical tests of classical models and reveal new modes of morphogen regulation and readout in one of the most extensively studied patterning systems.
Shvartsman
Stanislav Y
SY
Department of Chemical Engineering and Lewis-Sigler Institute for Integrative Genomics, Princeton University, New Jersey, United States. stas@Princeton.edu
Coppey
Mathieu
M
Berezhkovskii
Alexander M
AM
D000818:Animals; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D004330:Drosophila / Q000196:embryology* / Q000235:genetics / Q000378:metabolism; D004625:Embryo, Nonmammalian; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D019476:Insect Proteins / Q000378:metabolism* / Q000494:pharmacology; D008954:Models, Biological; D009024:Morphogenesis / Q000235:genetics / Q000502:physiology*; D021381:Protein Transport; D015398:Signal Transduction / Q000502:physiology
D019476:Insect Proteins; D048049:Extracellular Signal-Regulated MAP Kinases