Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition.
A versatile synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxylate esters has been developed which has lead to the identification of a new series of non-nucleoside inhibitors of human herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.
Schnute
Mark E
ME
Global Research and Development, Pfizer Inc., 700 Chesterfield Parkway West, St. Louis, MO 63017, USA. mark.e.schnute@pfizer.com
Brideau
Roger J
RJ
Collier
Sarah A
SA
Cudahy
Michele M
MM
Hopkins
Todd A
TA
Knechtel
Mary L
ML
Oien
Nancee L
NL
Sackett
Robert S
RS
Scott
Allen
A
Stephan
Mari L
ML
Wathen
Michael W
MW
Wieber
Janet L
JL
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003587:Cytomegalovirus / Q000201:enzymology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D004952:Esters; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D006564:Herpesviridae / Q000187:drug effects*; D014645:Herpesvirus 3, Human / Q000201:enzymology; D004854:Herpesvirus 4, Human / Q000201:enzymology; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D008968:Molecular Conformation; D019384:Nucleic Acid Synthesis Inhibitors; D011728:Pyridones / Q000138:chemical synthesis* / Q000494:pharmacology; D018139:Simplexvirus / Q000201:enzymology
C532910:4-oxo-4,7-dihydrofuro(2,3-b)pyridine-5-carboxamide; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D004952:Esters; D005663:Furans; D019384:Nucleic Acid Synthesis Inhibitors; D011728:Pyridones