[Expression of TM4SF9 in human trophoblasts].
OBJECTIVE
To investigate the expression of TM4SF9 in the villi of early pregnancy, hydatidiform mole, invasive hydatidiform mole and chorionic carcinoma tissue.


METHODS
Immunohistochemistry was used to detect the expression of TM4SF9 in normal villi of early pregnancy, hydatidiform mole, invasive hydatidiform mole and chorionic carcinoma tissues.


RESULTS
TM4SF9 was expressed in the cytotroblasts but not in the syncytiotrophoblast of normal villi. The intensity of TM4SF9 expression increased in the order of normal villi, hydatidiform mole, invasive hydatidiform mole and chorionic carcinoma, with strong positivity rates of 0, 10%, 36.4% and 100%, respectively, showing significant differences between the samples (P<0.001).


CONCLUSIONS
TM4SF9 expression in the trophoblasts may relate to their invasiveness and play an important role in the metastasis of trophoblastic tumor.
Gao
Tian-Yang
TY
Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. gaotianyang@yahoo.com
Yu
Yan-Hong
YH
D000328:Adult; D002822:Choriocarcinoma / Q000378:metabolism; D002824:Chorionic Villi / Q000378:metabolism; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000378:metabolism; D002820:Hydatidiform Mole, Invasive / Q000378:metabolism; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000096:biosynthesis*; D011247:Pregnancy; D059470:Tetraspanins; D014328:Trophoblastic Neoplasms / Q000378:metabolism*; D014327:Trophoblasts / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism*
D008565:Membrane Proteins; D059470:Tetraspanins; C435756:Tspan5 protein, mouse