Hyperuricosuria, an often overlooked cause of recurrent oliguria in children.
The association of oliguria with hyperuricosuria is often overlooked. Herein, we report an infant who since the age of five months had recurrent oliguria secondary to hyperuricosuria documented several times in the hospital. The decreased urine output coincided with the presence of increased excretion of uric acid, which fluctuated within 24 hours as well as every few weeks. The child responded to treatment with increase in the fluid fluid intake along with the xanthine oxidase inhibitor, allopurinol. Being alert for hyperuricosuria in cases of oliguria, especially if there is history of gout or stones, may avoid performing many unnecessary investigations.
Akl
Kamal
K
Faculty of Medicine, Department of Pediatrics, Jordan University Hospital, Amman, Jordan. kachbl@yahoo.com
D019883:Alkyl and Aryl Transferases; D000493:Allopurinol / Q000627:therapeutic use*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D009846:Oliguria / Q000209:etiology*; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood*; D014570:Urologic Diseases / Q000150:complications* / Q000188:drug therapy*
D014527:Uric Acid; D000493:Allopurinol; D019883:Alkyl and Aryl Transferases; C112459:geranylpyrophosphate olivetolate geranyltransferase