Effects of various amino acids on methionine-induced hyperhomocysteinemia in rats.
Rats were fed diets supplemented with 1% L-methionine with and without 2.5% various amino acids for 7 d to determine what amino acids other than glycine, serine, and cystine can suppress methionine-induced hyperhomocysteinemia. L-Glutamic acid, L-histidine, and L-arginine significantly suppressed methionine-induced enhancement of plasma homocysteine concentrations, but the mechanisms underlying the effect of these amino acids are thought not to be identical.
Fukada
Shin-ichiro
S
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka, Japan.
Morita
Tatsuya
T
Sugiyama
Kimio
K
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001120:Arginine / Q000494:pharmacology; D019587:Dietary Supplements; D018698:Glutamic Acid / Q000494:pharmacology; D006639:Histidine / Q000494:pharmacology; D006710:Homocysteine / Q000097:blood; D020138:Hyperhomocysteinemia / Q000139:chemically induced / Q000188:drug therapy*; D008715:Methionine; D051381:Rats
D000596:Amino Acids; D006710:Homocysteine; D018698:Glutamic Acid; D006639:Histidine; D001120:Arginine; D008715:Methionine