Small RNAs and cancerogenesis.
Disturbances of microRNA generation and functioning as inhibitors of gene expression at the translational level are considered as specific and diagnostic features of cancer. This review also highlights the role of short interfering RNA (siRNA) in modified epigenomic chromatin structure, which may cause cancer transformation. Future directions of cancer epigenomics are considered in the light of the involvement of siRNA in epigenomic modification of chromatin.
Ryazansky
S S
SS
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow 123182, Russia. ryazansky@img.ras.ru
Gvozdev
V A
VA
D000818:Animals; D001483:Base Sequence; D004251:DNA Transposable Elements; D044127:Epigenesis, Genetic; D016678:Genome / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics* / Q000378:metabolism*
D004251:DNA Transposable Elements; D035683:MicroRNAs; D034741:RNA, Small Interfering