title: Integrating host genomics with surveillance for invasive bacterial diseases.
abstract: We tested the feasibility of linking Active Bacterial Core surveillance, a prospective, population-based surveillance system for invasive bacterial disease, to a newborn dried blood spot (nDBS) repository. Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease.
authors.affiliation: Vanderbilt University, Nashville, Tennessee, USA.
authors.forename: Dana C
authors.initials: DC
authors.lastname: Crawford
authors.forename: Shanta M
authors.initials: SM
authors.lastname: Zimmer
authors.forename: Craig A
authors.initials: CA
authors.lastname: Morin
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Messonnier
authors.forename: Ruth
authors.initials: R
authors.lastname: Lynfield
authors.forename: Qian
authors.initials: Q
authors.lastname: Yi
authors.forename: Cynthia
authors.initials: C
authors.lastname: Shephard
authors.forename: Michelle
authors.initials: M
authors.lastname: Wong
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Rieder
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Livingston
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Nickerson
authors.forename: Cynthia G
authors.initials: CG
authors.lastname: Whitney
authors.forename: Jairam
authors.initials: J
authors.lastname: Lingappa
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D005240:Feasibility Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D051916:Membrane Cofactor Protein / Q000235:genetics; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000235:genetics*; D015997:Neonatal Screening; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011159:Population Surveillance; D012189:Retrospective Studies
chemical_list: C497857:CD46 protein, human; D051916:Membrane Cofactor Protein