Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism.
Adenosine A(2A) antagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A(2A) antagonist) to reverse the locomotor suppression and tremor produced by dopamine antagonists in rats. MSX-3 reversed haloperidol-induced suppression of locomotion, and reduced the tremulous jaw movements induced by haloperidol, pimozide, and reserpine. Infusions of MSX-3 into the nucleus accumbens core increased locomotion in haloperidol-treated rats, but there were no effects of infusions into the accumbens shell or ventrolateral neostriatum. In contrast, MSX-3 injected into the ventrolateral neostriatum reduced pimozide-induced tremulous jaw movements. Dopamine/adenosine interactions in different striatal subregions are involved in distinct aspects of motor function.
Salamone
John D
JD
Behavioral Neuroscience Division, Department of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA. john.salamone@uconn.edu
Ishiwari
Keita
K
Betz
Adrienne J
AJ
Farrar
Andrew M
AM
Mingote
Susana M
SM
Font
Laura
L
Hockemeyer
Jörg
J
Müller
Christa E
CE
Correa
Mercè
M
D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D008124:Locomotion / Q000502:physiology*; D010300:Parkinson Disease / Q000209:etiology*; D014202:Tremor / Q000150:complications / Q000378:metabolism / Q000503:physiopathology
D000241:Adenosine; D004298:Dopamine