Saengshik, a formulated health food, prevents liver damage in CCl4-induced mice and increases antioxidant activity in elderly women.
Saengshik is a Korean noncooked food made with of more than 30 different whole gains, vegetables, fruits, mushrooms, and seaweeds. All of these ingredients are frozen and dried to minimize the loss of nutrients. Saengshik has become popular among health-conscious people in the Republic of Korea. The study aims to investigate antioxidant effects of Saengshik by in vivo and human experiments. In in vivo tests, mice were fed Saengshik for 4 weeks, and oxidative damage was induced by CCl(4). Then the effects of Saengshik on oxidative damage were examined. It was found that plasma lipid hydroperoxide and protein oxidative damages were significantly suppressed and antioxidants, glutathione, and thiol groups were increased. The activity of the antioxidant enzyme superoxide dismutase was increased, and the level of glutamate pyruvate transaminase was decreased. In a human study, elderly people were given Saengshik for 24 weeks, and changes in antioxidant defense of the body were examined. Antioxidant activities in plasma were enhanced, although the difference was not significant. Therefore, it is expected that Saengshik is effective at removing oxidants from body tissues, preventing oxidative damage, and eventually boosting the antioxidant capacity of the body.
Kim
Hwa-young
HY
Erom R&D Center, Kyungwon University, Seongnam, Republic of Korea.
Kim
Joong-Hark
JH
Lee
Seong-Ae
SA
Chang
Hey-eun
HE
Park
Mi-hyoun
MH
Hwang
Sung-joo
SJ
Lee
Ju-yeon
JY
Mok
Chulkyoon
C
Hong
Seong-gil
SG
D000363:Agaricales; D000368:Aged; D000375:Aging / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000032:analysis*; D002251:Carbon Tetrachloride / Q000008:administration & dosage; D056486:Chemical and Drug Induced Liver Injury; D002523:Edible Grain; D005260:Female; D005526:Food, Formulated; D058870:Food, Organic; D005638:Fruit; D005978:Glutathione / Q000032:analysis; D006801:Humans; D007723:Korea; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000032:analysis / Q000097:blood; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008107:Liver Diseases / Q000517:prevention & control*; D051379:Mice; D008813:Mice, Inbred ICR; D010084:Oxidation-Reduction; D012624:Seaweed; D014675:Vegetables
D000975:Antioxidants; D008054:Lipid Peroxides; D002251:Carbon Tetrachloride; D005978:Glutathione