Direct contrasts between experimental conditions may yield more focal oscillatory activations than comparing pre- versus post-stimulus responses.
Contrasting electro- or magnetoencephalographic oscillatory responses to sensory stimuli with a pre-stimulation baseline commonly yields spectrally broad and topographically distributed activations. In contrast, comparisons between closely matched task conditions usually result in more focal differences. In the present study, we reanalyzed an existing set of MEG data recorded during stimulation with virtual Kanizsa figures and no-triangle control stimuli to contrast results yielded by the two approaches. Statistical analysis showed that visual stimulation compared to baseline gave rise to spectral amplitude reductions in lower frequencies including alpha and beta and amplitude enhancements in gamma frequencies above 55 Hz. These changes reached significance by about 100 ms post-stimulus onset, were topographically widespread over posterior cortex, and did not differ between stimuli. A second, more focal component over ventral occipital cortex peaked at about 300 ms in the gamma range at approximately 70 Hz. It was more pronounced for the Kanizsa triangle than for the no-triangle stimulus. A third gamma component over lateral occipito-temporal cortex showed an amplitude increase at around 450 ms for virtual figures and a concomitant decrease for the nongestalt-like control stimulus, and no overall task-related activity. Our findings illustrate that direct comparisons between conditions yield effects with a more focal spectral and topographical distribution than comparisons with a pre-stimulus baseline. Moreover, they exemplify that contrasts between conditions may reveal additional activations not captured by comparisons with a pre-stimulus baseline.
Kaiser
Jochen
J
Institute of Medical Psychology, Johann Wolfgang Goethe University, Heinrich-Hoffmann-Str. 10, 60528 Frankfurt am Main, Germany. j.kaiser@med.uni-frankfurt.de
Rahm
Benjamin
B
Lutzenberger
Werner
W
D000328:Adult; D000513:Alpha Rhythm; D001611:Beta Rhythm; D001683:Biological Clocks / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology; D055815:Young Adult