No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population.
PLP1 is one of the major myelin-related genes. A large body of expression-based studies showed significantly lower levels of the PLP1 messenger ribonucleic acid (mRNA) transcripts in schizophrenia. Moreover, one family-based study identified a weak association signal in a male subset using 487 Chinese family trios. We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor.
Aleksic
Branko
B
Department of Psychiatry, Graduate School of Medicine, Nagoya University, Showa-ku, Tsurumai-Cho, 65, Nagoya, Aichi, 466-8550, Japan. branko@med.nagoya-u.ac.jp.|Department of Psychiatry, Graduate School of Medicine, Fujita Health University, Aichi, Japan. branko@med.nagoya-u.ac.jp.|CREST, Japan Science and Technology Agency, Saitama, 332-0012, Japan. branko@med.nagoya-u.ac.jp.
Ikeda
Masashi
M
Department of Psychiatry, Graduate School of Medicine, Fujita Health University, Aichi, Japan.|CREST, Japan Science and Technology Agency, Saitama, 332-0012, Japan.
Ishihara
Ryoko
R
Department of Psychiatry, Graduate School of Medicine, Nagoya University, Showa-ku, Tsurumai-Cho, 65, Nagoya, Aichi, 466-8550, Japan.|CREST, Japan Science and Technology Agency, Saitama, 332-0012, Japan.
Saito
Shinichi
S
Department of Psychiatry, Graduate School of Medicine, Nagoya University, Showa-ku, Tsurumai-Cho, 65, Nagoya, Aichi, 466-8550, Japan.|CREST, Japan Science and Technology Agency, Saitama, 332-0012, Japan.
Inada
Toshiya
T
Seiwa Hospital, Institute of Neuropsychiatry, Tokyo, Japan.
Iwata
Nakao
N
Department of Psychiatry, Graduate School of Medicine, Fujita Health University, Aichi, Japan.|CREST, Japan Science and Technology Agency, Saitama, 332-0012, Japan.
Ozaki
Norio
N
Department of Psychiatry, Graduate School of Medicine, Nagoya University, Showa-ku, Tsurumai-Cho, 65, Nagoya, Aichi, 466-8550, Japan.|CREST, Japan Science and Technology Agency, Saitama, 332-0012, Japan.
D000328:Adult; D005260:Female; D005787:Gene Frequency; D005820:Genetic Testing; D005828:Genetics, Population; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D018991:Myelin Proteolipid Protein / Q000235:genetics* / Q000378:metabolism; D009836:Oligodendroglia / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
D018991:Myelin Proteolipid Protein; C472930:PLP1 protein, human