[Effect of Jiawei Sini Decoction on HPA function of rats with restraint psychological stress].
OBJECTIVE
To observe the effect of Jiawei Sini Decoction (JWSND) on HPA function of rats with restraint psychological stress and the pathway of thymus immunosuppressive function.


METHODS
The rats were randomly divided into 4 groups, control group (C), model group (M), group treated by JWSND ( C1) and ginsenosides ( C2). Hypothalamus CRH, blood plasma ACTH and CORT, the numberofthy moeyte GCR sites and the GCR nuclear translocation rate were detected by radioimmunoassay.


RESULTS
Compared with C, in M, Hypothalamus CRH, blood plasma ACTH and CORT increased significantly (P < 0.01), but all these of C1 and C2 lowered significantly (P < 0.05, P < 0.01). Compared with C, the GCR nuclear translocation rate was increased significantly(P < 0. 01). Compared with M, the GCR nuclear translocation rate lowered significantly ( P < 0.01). Moreover, no significant difference was found in all indexes between C1 and C.


CONCLUSIONS
JWSND participates effectively in the adjustment of HPA of the rats with restraint psychological stress, and relieves significantly the inhibitory effect of glucocorticoid on the thymus, the pathway closely relates to the translocation of GCR.
Shi
Ya-fei
YF
Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Yan
Can
C
Wu
Li-li
LL
Ran
Chuan-lian
CL
Li
Qiang
Q
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000502:physiology; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000502:physiology; D010946:Plants, Medicinal / Q000737:chemistry; D011863:Radioimmunoassay; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical / Q000009:adverse effects; D013315:Stress, Psychological / Q000097:blood / Q000209:etiology / Q000503:physiopathology*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C530866:jiawei sini; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone