title: Determination of the GSTM1 gene deletion frequency in Parkinson's disease by allele specific PCR.
abstract: We have examined the occurrence of GSTM1 null, one of the glutathione S-transferase mu genes, in a control and a Parkinson's disease group. By using the polymerase chain reaction (PCR) we found 67% of non-expressors compared with 51% in a control group (chi(1)(2) = 5.535; p < 0.025). These results suggest that a deletion of the GSTM1 gene may be associated with a susceptibility to Parkinson's disease.
authors.affiliation: Department of Biochemistry, University of Birmingham, Birmingham, U.K.
authors.forename: M C
authors.initials: MC
authors.lastname: Stroombergen
authors.forename: R H
authors.initials: RH
authors.lastname: Waring
authors.forename: P
authors.initials: P
authors.lastname: Bennett
authors.forename: A C
authors.initials: AC
authors.lastname: Williams