[A case of ischemic skin necrosis after glypressin therapy in liver cirrhosis].
Terlipressin is a synthetic analogue of vasopressin, which has been used in the treatment of acute variceal hemorrhage. In contrast to vasopressin, terlipressin can be administered as intermittent injections instead of continuous intravenous infusion. Thus, it has a less adverse reaction than vasopressin. We report a case of ischemic skin complication in a cirrhotic patient treated with terlipressin. A 71-year-old man with liver cirrhosis was admitted because of hematemesis and melena. He was commenced on terlipressin at a dose 1 mg every 6 hours for the treatment of varicieal bleeding. After 36 hours of treatment, skin blistering and ecchymosis was noted on the skin of his upper thigh, scrotal area and trunk. We found that terlipressin was a possible cause of ischemic skin complication based on the skin biopsy finding. Terlipressin may induce a complication of the ischemic event. In spite of rarity, special attention needs to paid on the peripheral ischemic complication of terlipressin.
Oh
Ji Eun
JE
Department of Internal Medicince, Masan Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Ha
Jung Soo
JS
Cho
Dae Hyeon
DH
Yu
Gil Jong
GJ
Shim
Sang Goon
SG
D000368:Aged; D017809:Fatal Outcome; D006396:Hematemesis / Q000175:diagnosis; D006470:Hemorrhage / Q000188:drug therapy; D006801:Humans; D007511:Ischemia / Q000139:chemically induced* / Q000473:pathology*; D008103:Liver Cirrhosis / Q000150:complications*; D008236:Lypressin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008551:Melena / Q000175:diagnosis; D009336:Necrosis; D012867:Skin / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology*; D000077585:Terlipressin; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D014662:Vasoconstrictor Agents; D008236:Lypressin; D000077585:Terlipressin