Lack of multiple copies of pfmdr1 gene in Papua New Guinea.
We describe here the results of an analysis of Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene copy number from 440 field isolates from Papua New Guinea. No multiple copies of the gene were found, which corresponds to the lack of usage of mefloquine. These data extend regional knowledge about the distribution of multidrug-resistant P. falciparum.
Hodel
Eva Maria
EM
Swiss Tropical Institute, Socinstrasse 57, P.O. Box 4002 Basle, Switzerland.
Marfurt
Jutta
J
Müller
Dania
D
Rippert
Anja
A
Borrmann
Steffen
S
Müller
Ivo
I
Reeder
John C
JC
Siba
Peter
P
Genton
Blaise
B
Beck
Hans-Peter
HP
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D037621:Artemisinins / Q000627:therapeutic use; D000077332:Artesunate; D004351:Drug Resistance / Q000235:genetics; D019450:Genes, MDR / Q000235:genetics; D005838:Genotype; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000235:genetics*; D015767:Mefloquine / Q000627:therapeutic use; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics*; D010219:Papua New Guinea; D010963:Plasmodium falciparum / Q000187:drug effects / Q000235:genetics*; D011110:Polymorphism, Genetic
D000962:Antimalarials; D037621:Artemisinins; D000077332:Artesunate; D015767:Mefloquine; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C513498:Mdr1 protein, Plasmodium falciparum