title: The role of trehalose and its transporter in protection against reactive oxygen species.
abstract: During menadione stress, trehalose was necessary intracellularly, but under H2O2, the sugar was required on the outside of the plasma membrane. The mechanism of protection involves minimizing the oxidative damage caused to both proteins and lipids, which would require the presence of trehalose on both sides of the lipid bilayer.
authors.affiliation: Departamento de Bioquímica, Instituto de Química, UFRJ, 21941-909 Rio de Janeiro, RJ, Brazil.
authors.forename: Débora
authors.initials: D
authors.lastname: da Costa Morato Nery
authors.forename: Carmelita Gomes
authors.initials: CG
authors.lastname: da Silva
authors.forename: Diana
authors.initials: D
authors.lastname: Mariani
authors.forename: Patrícia Neves
authors.initials: PN
authors.lastname: Fernandes
authors.forename: Marcos Dias
authors.initials: MD
authors.lastname: Pereira
authors.forename: Anita Dolly
authors.initials: AD
authors.lastname: Panek
authors.forename: Elis Cristina Araújo
authors.initials: EC
authors.lastname: Eleutherio
mesh_terms: D005964:Glucosyltransferases / Q000235:genetics; D006861:Hydrogen Peroxide / Q000494:pharmacology; D015227:Lipid Peroxidation; D009004:Monosaccharide Transport Proteins / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress; D050050:Protein Carbonylation; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology*; D027981:Symporters / Q000235:genetics / Q000502:physiology*; D014199:Trehalose / Q000494:pharmacology / Q000502:physiology*; D024483:Vitamin K 3 / Q000494:pharmacology
chemical_list: D009004:Monosaccharide Transport Proteins; D016877:Oxidants; D017382:Reactive Oxygen Species; D029701:Saccharomyces cerevisiae Proteins; D027981:Symporters; C067575:maltose transport system, S cerevisiae; D024483:Vitamin K 3; D014199:Trehalose; D006861:Hydrogen Peroxide; D005964:Glucosyltransferases; C023180:trehalose-6-phosphate synthase