Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6J mice fed on a high-fat diet.
The aim of present study is to evaluate the effects of Garcinia cambogia on the mRNA levels of the various genes involved in adipogenesis, as well as on body weight gain, visceral fat accumulation, and other biochemical markers of obesity in obesity-prone C57BL/6J mice. Consumption of the Garcinia cambogia extract effectively lowered the body weight gain, visceral fat accumulation, blood and hepatic lipid concentrations, and plasma insulin and leptin levels in a high-fat diet (HFD)-induced obesity mouse model. The Garcinia cambogia extract reversed the HFD-induced changes in the expression pattern of such epididymal adipose tissue genes as adipocyte protein aP2 (aP2), sterol regulatory element-binding factor 1c (SREBP1c), peroxisome proliferator-activated receptor gamma2 (PPARgamma2), and CCAT/enhancer-binding protein alpha (C/EBPalpha). These findings suggest that the Garcinia cambogia extract ameliorated HFD-induced obesity, probably by modulating multiple genes associated with adipogenesis, such as aP2, SREBP1c, PPARgamma2, and C/EBPalpha in the visceral fat tissue of mice.
Kim
Keun-Young
KY
Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul, Korea.
Lee
Hye Nam
HN
Kim
Yun Jung
YJ
Park
Taesun
T
D050156:Adipogenesis / Q000187:drug effects / Q000235:genetics; D050154:Adiposity / Q000187:drug effects*; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D029761:Garcinia cambogia / Q000737:chemistry*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D007328:Insulin / Q000097:blood; D050152:Intra-Abdominal Fat / Q000187:drug effects*; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000032:analysis; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D015430:Weight Gain / Q000187:drug effects
D004041:Dietary Fats; D007328:Insulin; D020738:Leptin; D008055:Lipids; D010936:Plant Extracts