Application of systems biology for bioprocess development.
Random mutagenesis or genetic modification of an organism without consideration of its consequences to the entire system might cause unwanted changes in cellular metabolism. Systems metabolic engineering thus aims to develop strains by performing metabolic engineering within a systems biology framework, in which entire cellular networks are optimized and fermentation and downstream processes are considered at early stages. Thus, regulatory, metabolic and other cellular networks are engineered in an integrated manner. Here, we review the applications of systems biology for the development of strains and bioprocesses by means of several successful examples and, furthermore, discuss future prospects.
Park
Jin Hwan
JH
Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST, Daejeon 305-701, Korea.
Lee
Sang Yup
SY
Kim
Tae Yong
TY
Kim
Hyun Uk
HU
D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D019149:Bioreactors; D005658:Fungi / Q000235:genetics / Q000378:metabolism*; D005818:Genetic Engineering / Q000379:methods*; D016678:Genome; D053858:Metabolic Networks and Pathways; D012984:Software; D049490:Systems Biology