Complement factor H Y402H polymorphism, plasma concentration and risk of coronary artery disease.
BACKGROUND
Inflammation plays an important role in coronary artery disease (CAD). Complement Factor H (CFH) gene has been analyzed in relation to CAD in several studies with conflicting results. The aim of the present study was to investigate the association between the CFH Y402H polymorphism and CAD in Chinese.


RESULTS
About 336 patients were enrolled, included 166 patients with CAD and 170 controls. The SNP at CFH Y402H was genotyped by ligase detection reaction and plasma levels of CFH were assayed by enzyme-linked immunosorbent assay. Analysis of genotype frequencies did not reveal any significant difference between CAD patients and controls. There were significant differences in the frequencies of C allele and C allele carriers between early-onset CAD and controls. After adjustment of clinical parameters, significant association was identified for CFH Y402H polymorphism, with C allele carriers having a higher risk of early-onset CAD than carriers of TT genotype (odds ratio [OR] 4.66, 95% CI: 1.23-17.62, P = 0.02). There was no difference of plasma CFH levels between CAD group and controls.


CONCLUSIONS
CFH Y402H polymorphism is associated with early-onset CAD in Chinese.
Qian
Qi
Q
Clinical Medical College of Southeast University, Nanjing, 210009, People's Republic of China.
Chen
Zhong
Z
Ma
Genshan
G
Jiang
Yibo
Y
Feng
Yi
Y
Shen
Chengxing
C
Yao
Yuyu
Y
Ding
Jiandong
J
Dai
Qiming
Q
Li
Yongjun
Y
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D017242:Complement Factor H / Q000235:genetics*; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012306:Risk
D017242:Complement Factor H