In vivo monitoring of intravenously injected gold nanorods using near-infrared light.
Gold nanorods showing surface plasmon (SP) bands in the near-IR region are used as bioimaging probes that respond to near-IR light in mice. The SP bands of intravenously injected polyethylene glycol-modified gold nanorods are directly monitored from the mouse abdomen by using a spectrophotometer equipped with an integrating sphere. The absorbance at 900 nm from the gold nanorods immediately increases after injection and reaches a plateau. The injection of phosphatidylcholine-modified gold nanorods also increases the absorbance at 900 nm, but the absorbance decreases single exponentially with a 1.3-min half-life. In vivo spectral changes of gold nanorods depend on the surface characteristics, and can be observed in real time using simple spectroscopic measurements.
Niidome
Takuro
T
Department of Applied Chemistry, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan. niidome-tcm@mbox.nc.kyushu-u.ac.jp
Akiyama
Yasuyuki
Y
Shimoda
Kohei
K
Kawano
Takahito
T
Mori
Takeshi
T
Katayama
Yoshiki
Y
Niidome
Yasuro
Y
D000818:Animals; D001703:Biophysics / Q000379:methods; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D006018:Glycols / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D007259:Infrared Rays; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008823:Micelles; D043942:Nanotubes / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods; D019265:Spectroscopy, Near-Infrared / Q000379:methods
D002593:Cetrimonium Compounds; D006018:Glycols; D008823:Micelles; D010713:Phosphatidylcholines; D011092:Polyethylene Glycols; D006046:Gold; D000077286:Cetrimonium