title: [Bioequivalence of enteric coated tablet of Zhengqing Fengtongning].
abstract: OBJECTIVE
  To explore the pharmacokinetics and bioequivalence of two kinds of enteric coated tablet of Zhengqing Fengtongning.
  
  
  METHODS
  A single dose of 45 mg kg(-1) test or reference preparation was administrated by randomized crossover way in 12 rabbits. The plasma concentrations of drug were determined by HPLC. The pharmacokinetics parameters and relative bioequivalence were calculated with 3p97 program.
  
  
  RESULTS
  The concentration curves based on drug-time of both test and control preparations were presented by one-compartment model, tmax were (0.81 +/- 0.34), (0.60 +/- 0.30) h respectively, Cmax were (11.16 +/- 0.58), (11.90 +/- 1.44) microg mL(1) respectively, AUC(0-->t) were (61.58 +/- 6.70), (60.56 +/- 6.67) microg h mL(-1) respectively, relative bioavailability was (102.77% +/- 15.63)%. Suggesting no significant diffirence between the main pharmacokinetic parameters of two prepations.
  
  
  CONCLUSIONS
  The two preparations are bioequivalent.
authors.affiliation: Clinical Pharmacology Laboratory, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China. hanshi20022004@l.com
authors.forename: Si-Han
authors.initials: SH
authors.lastname: Zhang
authors.forename: Yuan-Da
authors.initials: YD
authors.lastname: Zhou
authors.forename: Hai-Xia
authors.initials: HX
authors.lastname: He
mesh_terms: D000818:Animals; D001682:Biological Availability; D018592:Cross-Over Studies; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D005260:Female; D008297:Male; D011817:Rabbits; D011897:Random Allocation; D013608:Tablets, Enteric-Coated; D013810:Therapeutic Equivalency
chemical_list: D004365:Drugs, Chinese Herbal; D013608:Tablets, Enteric-Coated; C540317:Zhengqing Fengtongning