title: X-ray phase radiography and tomography of soft tissue using grating interferometry.
abstract: X-ray phase and absorption radiographs and tomograms of the heart of a rat were taken with an X-ray grating interferometer with monochromatic synchrotron radiation at a photon energy of 17.5 keV. The phase images show largely superior quality with respect to the absorption images taken with the same dose, particularly much better contrast and contrast-to-noise ratio. Different tissues can clearly be distinguished. The results demonstrate the potential of grating interferometry for two- and three-dimensional X-ray imaging of biological soft tissue in an aqueous environment.
authors.affiliation: European Synchrotron Radiation Facility, 6 rue Jules Horowitz, BP 220, 38043 Grenoble, France. weitkamp@esrf.fr
authors.forename: Timm
authors.initials: T
authors.lastname: Weitkamp
authors.forename: Christian
authors.initials: C
authors.lastname: David
authors.forename: Oliver
authors.initials: O
authors.lastname: Bunk
authors.forename: Jens
authors.initials: J
authors.lastname: Bruder
authors.forename: Peter
authors.initials: P
authors.lastname: Cloetens
authors.forename: Franz
authors.initials: F
authors.lastname: Pfeiffer
mesh_terms: D000465:Algorithms; D000818:Animals; D006321:Heart / Q000000981:diagnostic imaging*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007368:Interferometry / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D051381:Rats; D012031:Refractometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014056:Tomography, X-Ray / Q000379:methods*