Role of plasma proteins in pharmacokinetics of micafungin, an antifungal antibiotic, in analbuminemic rats.
There were no significant differences in the pharmacokinetics of micafungin and expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2) between analbuminemic and Sprague-Dawley rats. Micafungin bound strongly to high-density lipoprotein (HDL) and moderately to gamma globulin. These results suggest that HDL and gamma globulin contribute to the pharmacokinetics of micafungin.
Abe
Fumie
F
Department of Pharmacy and Pharmacokinetics, Aichi Medical University School of Medicine, Nagakute-cho, Aichi-gun, Aichi, Japan.
Ueyama
Jun
J
Kawasumi
Noriyo
N
Nadai
Masayuki
M
Hayashi
Tamon
T
Kato
Miki
M
Ohnishi
Masafumi
M
Saito
Hiroko
H
Takeyama
Naoshi
N
Hasegawa
Takaaki
T
D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D001798:Blood Proteins / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000378:metabolism; D054714:Echinocandins / Q000493:pharmacokinetics*; D055666:Lipopeptides; D008074:Lipoproteins / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D000077551:Micafungin; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000172:deficiency* / Q000378:metabolism; D005719:gamma-Globulins / Q000378:metabolism
D000935:Antifungal Agents; D001798:Blood Proteins; D008076:Cholesterol, HDL; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D000077551:Micafungin; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D012709:Serum Albumin; D005719:gamma-Globulins