[Low levels of 25-hydroxyvitamin D (25OHD) in patients with inflammatory bowel disease and its correlation with bone mineral density].
Patients with inflammatory bowel disease (IBD) are at risk of having vitamin D deficiency (25-OHD) and low bone mineral density (BMD).


OBJECTIVE
To measure 25OHD in a young group of IBD patients submitted to a clinical evaluation, routine biochemistry and BMD measurement (lumbar spine and proximal femur).


RESULTS
39 Crohn disease (CD) and 37 ulcerative colitis (UC) patients had lower serum levels of 25OHD compared to the control group (CD p = 0.003; UC p < 0.001), and 48.5% of the UC patients were 25OHD deficient. Lumbar spine BMD was lower in patients than controls (CD p = 0.001; UC p = 0.008). In CD patients, serum levels of 25OHD were significantly correlated with total femur (r = 0.391; p = 0.027) and femoral neck (r = 0.384; p = 0.03) BMD.


CONCLUSIONS
It was found lower levels of 25OHD and BMD in young IBD patients compared to normal controls, suggesting an important role of 25OHD deficiency in the pathogenesis of the IBD bone disease.
Souza
Hevelyn Noemberg de
HN
Serviço de Endocrinologia e Metabologia, Hospital de Clínicas, Universidade Federal do Paraná, PR, Brasil.
Lora
Fabiana Lígia
FL
Kulak
Carolina A Moreira
CA
Mañas
Nádila Cecyn Pietszkowski
NC
Amarante
Heda M B
HM
Borba
Victória Z Cochenski
VZ
D000328:Adult; D015519:Bone Density; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000097:blood* / Q000150:complications; D003424:Crohn Disease / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology
D014807:Vitamin D; C104450:25-hydroxyvitamin D