title: Polycystic ovary syndrome with endometrial hyperplasia in a cynomolgus monkey (Macaca fascicularis).
abstract: A 13-year-old, obese, female cynomolgus monkey (Macaca fascicularis) was observed in a 5-year neurobehavioral study and was humanely euthanatized for experimental purposes. During this observational study, the monkey was noted to ovulate only rarely (0-3 times a year), with a prolonged menstrual cycle length (up to 161 days), hyperandrogenism (androstenedione area under the curve in response to adrenocorticotropic hormone up to 27.64 ng/ml), and hyperinsulinemia (fasting insulin up to 65.85 microIU/ml). This animal's body mass index was 65.46 kg/m(2), with central obesity. On postmortem examination, the uterus was moderately enlarged, with an eccentric lumen and a broad-based endometrial polyp that consisted of complex glandular hyperplasia with atypia. Both ovaries contained many 2- to 3-mm follicles, without any corpora lutea. A diagnosis of polycystic ovary syndrome was made based on the clinical history, endocrinology, and gross and histopathologic findings.
authors.affiliation: Department of Pathology, Comparative Medicine Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1040, USA.
authors.forename: E
authors.initials: E
authors.lastname: Arifin
authors.forename: C A
authors.initials: CA
authors.lastname: Shively
authors.forename: T C
authors.initials: TC
authors.lastname: Register
authors.forename: J M
authors.initials: JM
authors.lastname: Cline
mesh_terms: D000818:Animals; D004714:Endometrial Hyperplasia / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D005260:Female; D006651:Histocytochemistry; D008252:Macaca fascicularis; D008992:Monkey Diseases / Q000473:pathology*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000473:pathology / Q000662:veterinary*