[Aggregation function of platelets in persons with arterial hypertension and abdominal obesity].
In patients with arterial hypertension (AH) accompanied by abdominal obesity (AO) increase in platelets adhesive and aggregation functions was noted in vitro and in vivo. The cause of these disturbances is blood serum and platelets lipid peroxidation activation, increase in synthesis of Willebrand's factor in a vascular wall, and intensification of thromboxane production in platelets. Activation of thromboplastin production is the main cause of increase in blood coagulation in patients with AH and AO.
Simonenko
V B
VB
Medvedev
N N
NN
Nosova
T Iu
TIu
D000328:Adult; D001777:Blood Coagulation / Q000502:physiology*; D001792:Blood Platelets / Q000378:metabolism*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009767:Obesity, Morbid / Q000097:blood* / Q000150:complications; D010974:Platelet Aggregation / Q000502:physiology*; D010976:Platelet Count; D013925:Thromboplastin / Q000096:biosynthesis; D013931:Thromboxanes / Q000096:biosynthesis; D014841:von Willebrand Factor / Q000096:biosynthesis
D013931:Thromboxanes; D014841:von Willebrand Factor; D008315:Malondialdehyde; D013925:Thromboplastin