title: [Studies conducted in Spain on concentrations in humans of persistent toxic compounds].
abstract: No systematic review is available on studies conducted in Spain on human concentrations of persistent toxic substances (PTS). The objectives were: to identify studies conducted in Spain in the past 30 years that determined concentrations in humans of dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethane (DDE), hexachlorobenzene (HCB), hexachlorocyclohexane (HCH) and polychlorinated biphenyls (PCBs); and to summarize the main characteristics and results of each study. Studies are highly heterogeneous and most lack population representativeness. Concentrations of DDT and DDE might have decreased moderately in the last 20 years. Numerous fluctuations are apparent in levels of HCB, HCHs and PCBs, in some instances compatible with some stagnation. There are enormous differences in levels detected across and within studies: PTS concentrations of some individuals may be over 200-fold higher than those of others. The actual magnitude of human contamination by PTS and their trends across Spain -as well as the geographic and social heterogeneity- remain largely unknown.
authors.affiliation: Instituto Municipal de Investigación Médica, Barcelona, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España. mporta@imim.es
authors.forename: Miquel
authors.initials: M
authors.lastname: Porta
authors.forename: Elisa
authors.initials: E
authors.lastname: Puigdomènech
authors.forename: Ferran
authors.initials: F
authors.lastname: Ballester
authors.forename: Javier
authors.initials: J
authors.lastname: Selva
authors.forename: Núria
authors.initials: N
authors.lastname: Ribas-Fitó
authors.forename: Luis
authors.initials: L
authors.lastname: Domínguez-Boada
authors.forename: Piedad
authors.initials: P
authors.lastname: Martín-Olmedo
authors.forename: Nicolás
authors.initials: N
authors.lastname: Olea
authors.forename: Sabrina
authors.initials: S
authors.lastname: Llop
authors.forename: Marieta
authors.initials: M
authors.lastname: Fernández
mesh_terms: D015386:Hazardous Substances / Q000032:analysis*; D006801:Humans; D013030:Spain
chemical_list: D015386:Hazardous Substances