title: Poly(3,4-ethylenedioxythiophene) (PEDOT) nanobiointerfaces: thin, ultrasmooth, and functionalized PEDOT films with in vitro and in vivo biocompatibility.
abstract: Nanobiointerfaces were prepared based on an electrically conductive polyethylenedioxythiophene (PEDOT). Thin (<100 nm), ultrasmooth (roughness ( R(rms)) < 5 nm), and functionalized PEDOT films have been successfully electropolymerized using aqueous microemulsion. The microemulsion polymerization is found to be catalyzed in the presence of a low concentration of acid and allows for film formation from various functionalized ethylenedioxythiophenes (EDOTs) (e.g., EDOT-OH, C(2)-EDOT-COOH, C(4)-EDOT-COOH, C(2)-EDOT-NHS, EDOT-N(3)) and their mixtures. The nanobiointerfaces are compositionally tunable and controlled to deposit on selected electrode surfaces. They prefer orthogonal growth on patterned surfaces and are synthesized within seconds. These thin PEDOT films exhibit very low intrinsic cytotoxicity and display no inflammatory response upon implantation, making them ideal for biosensing and bioengineering applications.
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669.
authors.forename: Shyh-Chyang
authors.initials: SC
authors.lastname: Luo
authors.forename: Emril
authors.initials: E
authors.lastname: Mohamed Ali
authors.forename: Natalia C
authors.initials: NC
authors.lastname: Tansil
authors.forename: Hsiao-Hua
authors.initials: HH
authors.lastname: Yu
authors.forename: Shujun
authors.initials: S
authors.lastname: Gao
authors.forename: Eric A B
authors.initials: EA
authors.lastname: Kantchev
authors.forename: Jackie Y
authors.initials: JY
authors.lastname: Ying
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival; D004563:Electrochemistry; D006801:Humans; D051379:Mice; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D011108:Polymers / Q000737:chemistry*; D012996:Solutions; D013057:Spectrum Analysis
chemical_list: D001672:Biocompatible Materials; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011108:Polymers; D012996:Solutions; C121383:poly(3,4-ethylene dioxythiophene)