title: The modified BODE index: validation with mortality in COPD.
abstract: Peak oxygen uptake (V'(O(2))) remains the gold standard measurement of exercise capacity and has been associated with survival. A modified BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index replacing the 6-min walk distance (6MWD) with V'(O(2)) as % predicted (mBODE%) has been developed and found to have excellent correlation with the conventional BODE index. The objectives of the present study were to compare the ability of the conventional BODE and the mBODE% to predict mortality in 444 patients with chronic obstructive pulmonary disease (COPD) followed for a mean+/-SD period of 71+/-34 months. Anthropometrics, spirometry, lung volumes, comorbidity, cardiopulmonary cyclo-ergometry test and 6MWD were determined at entry. The mean BODE indices for the cohort were: BODE 4.1+/-2 and mBODE% 5.5+/-2. Both indices were significantly correlated with mortality. Logistic regression analysis with COPD survival as the dependent variable identified the BODE index, Charlson's and exercise capacity (in W) as variables associated with this outcome. In conclusion, the conventional BODE index, which uses the 6-min walk distance, predicts mortality in chronic obstructive pulmonary disease as well as the modified index using peak oxygen uptake. The results support the use of the simpler index, which includes the 6-min walk distance in the comprehensive evaluation of patients with chronic obstructive pulmonary disease.
authors.affiliation: Pulmonary and Critical Care Medicine, Bay Pines Veterans Administration Health Care System, 10, 000 Bay Pines Boulevard, Bay Pines, FL 33744, USA. claudia.cote@med.va.gov
authors.forename: C G
authors.initials: CG
authors.lastname: Cote
authors.forename: V M
authors.initials: VM
authors.lastname: Pinto-Plata
authors.forename: J M
authors.initials: JM
authors.lastname: Marin
authors.forename: H
authors.initials: H
authors.lastname: Nekach
authors.forename: L J
authors.initials: LJ
authors.lastname: Dordelly
authors.forename: B R
authors.initials: BR
authors.lastname: Celli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D015331:Cohort Studies; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000401:mortality* / Q000503:physiopathology; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D013147:Spirometry / Q000379:methods