Translational regulation by non-protein-coding RNAs: different targets, common themes.
There are several classes of small non-protein-coding RNA (npcRNA) that play important roles in cellular metabolism including mRNA decoding, RNA processing and mRNA stability. Indeed, altered expression of some of these npcRNAs has been associated with cancer, neurodegenerative diseases such as Alzheimer's disease, as well as various types of mental retardation and psychiatric disorders. The basis of this correlation is currently not understood. However, recent studies have begun to shed light on one of the mechanism(s) by which these RNAs exert their effects, namely, translational control. These data provide hope that rational treatments for these varied disorders may be in sight. Here, we review this new body of work.
Xie
Wen
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Department of Molecular Biology, Laboratory of Biochemical Molecular Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.
Ted Brown
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W
Denman
Robert B
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D020087:Alu Elements; D000818:Animals; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D010443:Peptide Chain Termination, Translational / Q000235:genetics*; D020733:RNA, Small Cytoplasmic / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000378:metabolism
C117734:BC1 RNA; D035683:MicroRNAs; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins