title: Plasma obestatin levels in men with chronic atrophic gastritis.
abstract: Obestatin is a recently discovered active peptide isolated from the stomach. The purpose of the present study was to investigate the modification of plasma obestatin levels in men with chronic atrophic gastritis. Men older than 65 years undergoing upper gastrointestinal endoscopy were included. All patients with chronic atrophic gastritis underwent multiple biopsies. Fasting plasma obestatin and ghrelin levels were examined in 50 men with chronic atrophic gastritis and 50 healthy men. Plasma obestatin levels were significantly lower in patients with chronic atrophic gastritis than in healthy subjects. Plasma ghrelin levels and ghrelin to obestatin ratio was decreased in men with chronic atrophic gastritis. There was a significant relationship between atrophy and decreased obestatin. A negative correlation was found between circulating obestatin levels and body mass index (BMI) in healthy subjects, but not in patients with chronic atrophic gastritis. The data indicated that chronic atrophic gastritis influenced plasma obestatin levels as well as ghrelin to obestatin ratio in elderly men.
authors.affiliation: Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin 150001, China.
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Gao
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Kuang
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Liu
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Ma
authors.forename: Hao-Jie
authors.initials: HJ
authors.lastname: Nie
authors.forename: Hong
authors.initials: H
authors.lastname: Guo
mesh_terms: D000368:Aged; D000818:Animals; D015992:Body Mass Index; D005757:Gastritis, Atrophic / Q000097:blood* / Q000473:pathology; D054439:Ghrelin / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D036361:Peptide Hormones / Q000097:blood*; D051381:Rats
chemical_list: D054439:Ghrelin; D007328:Insulin; D036361:Peptide Hormones; C505799:obestatin, human