Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery.
Emerging challenges within the current drug discovery paradigm are prompting renewed interest in natural products as a source of novel, bioactive small molecules. With the recent validation of zebrafish as a biomedically relevant model for functional genomics and in vivo drug discovery, the zebrafish bioassay-guided identification of natural products may be an attractive strategy to generate new lead compounds in a number of indication areas. Here, we review recent natural product research using zebrafish and evaluate the potential of this vertebrate model as a discovery platform for the systematic identification of bioactive natural products.
Crawford
Alexander D
AD
Department of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Leuven, Belgium. alexander.crawford@pharm.kuleuven.be
Esguerra
Camila V
CV
de Witte
Peter A M
PA
D000818:Animals; D001681:Biological Assay; D001688:Biological Products / Q000494:pharmacology*; D006801:Humans; D023421:Models, Animal; D015027:Zebrafish
D001688:Biological Products