Impaired gamma interferon response to Mycobacterium vaccae antigens in patients with cavitary pulmonary tuberculosis.
The ability of tuberculosis patients to recognize Mycobacterium vaccae-specific antigens before starting chemotherapy and according to disease severity was analyzed. We report that the M. vaccae cell wall skeleton fraction triggers more enhanced cytokine production than the whole bacterium. Moreover, a tendency was observed for a lower gamma interferon/interleukin-10 ratio in patients with cavitary disease induced by M. vaccae antigens.
Rodríguez-Güell
Elisabeth
E
Departament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Facultat de Biociències, 08193 Bellaterra, Barcelona, Spain.
Agustí
Gemma
G
Corominas
Mercè
M
Luquin
Marina
M
Julián
Esther
E
D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology*; D002478:Cells, Cultured; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D016753:Interleukin-10 / Q000096:biosynthesis; D007963:Leukocytes, Mononuclear / Q000276:immunology; D009161:Mycobacterium / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000382:microbiology*
D000942:Antigens, Bacterial; D016753:Interleukin-10; D007371:Interferon-gamma