title: Intermittent positive-pressure breathing effects in patients with high spinal cord injury.
abstract: OBJECTIVE
  To determine whether intermittent positive-pressure breathing (IPPB) improved lung compliance, work of breathing, and respiratory function in patients with recent high spinal cord injury (SCI).
  
  
  METHODS
  An unblinded randomized crossover trial.
  
  
  METHODS
  Rehabilitation hospital.
  
  
  METHODS
  Patients (N=14) with SCI caused by trauma within the last 6 months and located between C5 and T6.
  
  
  METHODS
  Two months of IPPB and 2 months of conventional treatment were evaluated prospectively in random order in patients with SCI.
  
  
  METHODS
  Noninvasive lung function tests and arterial blood gas measurements were obtained repeatedly in all patients. Repeated measurements of dynamic lung compliance and work of breathing as measured by computing the area enclosed between the inspiratory esophageal pressure-tidal volume curve, and the theoretical chest wall static pressure-volume curve were performed in 7 patients.
  
  
  RESULTS
  IPPB had no long-term effects on vital capacity (52.1%+/-11.3% vs 54.5%+/-12.5%, after conventional treatment and IPPB, respectively; P=.27), lung compliance (66.4+/-48.9 mL/cmH(2)O vs 70.3+/-38.4 mL/cmH(2)O; P=.56), or other lung function tests. IPPB did not exert short-term effects on lung compliance or work of breathing.
  
  
  CONCLUSIONS
  IPPB produced no immediate or long-term improvements in lung function or ventilatory mechanics in patients with recent SCI. (ClinicalTrials.gov identifier: NCT00476866.).
authors.affiliation: Centre d'Investigation Clinique-Innovations Technologiques, Hôpital Raymond Poincaré, University of Versailles Saint Quentin en Yvelines, Garches, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Laffont
authors.forename: Djamel
authors.initials: D
authors.lastname: Bensmail
authors.forename: Sylvie
authors.initials: S
authors.lastname: Lortat-Jacob
authors.forename: Line
authors.initials: L
authors.lastname: Falaize
authors.forename: Claudette
authors.initials: C
authors.lastname: Hutin
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Le Bomin
authors.forename: Maria
authors.initials: M
authors.lastname: Ruquet
authors.forename: Pierre
authors.initials: P
authors.lastname: Denys
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lofaso
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007384:Intermittent Positive-Pressure Breathing; D008170:Lung Compliance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D013119:Spinal Cord Injuries / Q000503:physiopathology* / Q000534:rehabilitation; D014939:Work of Breathing / Q000502:physiology