[Fascin expression in human epithelial tumors and its clinical significance].
OBJECTIVE
To investigate the expression of FSCN1 in human epithelial tumors and their clinical significance.


METHODS
FSCN1 expression was examined immunohistochemically in specimens of human epithelial tumors, including 26 cases of lung cancer, 33 cervical cancer, 22 ovarian cancer, 38 esophageal cancer, 24 pancreatic cancer, 23 gastric cancer, 29 laryngocarcinoma, 17 primary hepatocellular carcinoma, 34 colorectal cancer, 33 breast cancer, 24 nasopharyngeal carcinoma and their corresponding normal tissues.


RESULTS
The positivity rates of FSCN1 expression in epithelial tissues and epithelial tumors were 6.3% (5/80) and 58.7% (178/303), respectively. FSCN1 showed higher expressions in cervical cancer, ovarian cancer, esophageal cancer, pancreatic cancer, gastric cancer, laryngocarcinoma, colorectal cancer, breast cancer and nasopharyngeal carcinoma, but lower or no expression in the corresponding normal tissues (P<0.05). In gastric cancer and nasopharyngeal carcinoma, the edges of the tumors were more strongly stained for FSCN1 than the interior of the tumor.


CONCLUSIONS
FSCN1 expression is significantly upregulated in human epithelial tumors in close correlation with tumor occurrence and progression.
Gao
Xiang
X
Tung Wah Hospital Affiliated to Sun Yat-sen University, Dongguan 523110, China.
Wu
De-Hua
DH
D002352:Carrier Proteins / Q000096:biosynthesis*; D004938:Esophageal Neoplasms / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology; D008840:Microfilament Proteins / Q000096:biosynthesis*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology
D002352:Carrier Proteins; D008840:Microfilament Proteins; C020324:fascin