The cyclic AMP phenotype of fragile X and autism.
Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism.
Kelley
Daniel J
DJ
Waisman Laboratory for Brain Imaging and Behavior, Waisman Center, University of Wisconsin, Madison, WI, USA. djkelley@wisc.edu
Bhattacharyya
Anita
A
Lahvis
Garet P
GP
Yin
Jerry C P
JC
Malter
Jim
J
Davidson
Richard J
RJ
D000818:Animals; D001007:Anxiety / Q000378:metabolism; D001321:Autistic Disorder / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics; D005600:Fragile X Syndrome / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008568:Memory / Q000502:physiology; D008954:Models, Biological; D010641:Phenotype
D000242:Cyclic AMP; D051860:Fragile X Messenger Ribonucleoprotein 1