[Applications of metabonomics in clinical diagnosis].
Metabonomics, as a newly developed technique, is expected to be a powerful technique in clinical diagnosis. Metabonomics-based diagnosis involves the global metabolic analysis of body-fluids, determination of biomarkers by multivariate statistic analysis, and establishemen of mathematic models for clinical diagnosis with the aid of pattern recognition. This article reviews the adoption of various analytical and computational strategies, application of metabonomics in clinical diagnosis, and potential challenges and development trends.
Lin
Zhong-Ying
ZY
Modern Research Center for Traditional Chinese Medicine, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Yan
Shi-Kai
SK
Dai
Wei-Xing
WX
Yang
Yun
Y
Jin
Hui-Zi
HZ
Zhang
Chuan
C
Zhang
Wei-Dong
WD
D015415:Biomarkers / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism; D019937:Diagnostic Techniques and Procedures; D006801:Humans; D055442:Metabolome; D055432:Metabolomics / Q000379:methods*; D008962:Models, Theoretical; D015999:Multivariate Analysis
D015415:Biomarkers