[A genetic optimization designing method for microorganism detection genechip probe based on genetic algorithm].
A new automatic selection approach of microorganism specific fragment combination is presented in this paper. Genetic algorithm is used to search optimal solution on the basis of classification ability of SNP combination, which is evaluated by the rough set theory. Other related experimental parameters are also been incorporated. Experimental results show that the method can find the best SNP combination pattern efficiently and accurately, which implies that it is a reliable approach to the genechip probe design.
Liu
Guo-Chuan
GC
Beijing Institute of Radiation Medicine, Military Medical Science College, Beijing.
Bai
Zhi-Jun
ZJ
Shu
Wen-Jie
WJ
Bo
Xiao-Chen
XC
Wang
Sheng-Qi
SQ
Lu
Lin
L
Wang
Jia-Yong
JY
D000465:Algorithms; D008828:Microbiological Techniques / Q000379:methods*; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*