title: Reovirus: viral therapy for cancer 'as nature intended'.
abstract: Oncolytic viruses are tumour selective and able to lyse cancer cells after infection. Reovirus is an example of a wild-type oncolytic virus and is currently being investigated as a potential novel therapy for cancer. This overview gives a brief description of what is known about reovirus biology and summarises the preclinical data related to its oncolytic ability. The completed and ongoing clinical trials involving reovirus, both as a single agent and in combination with chemotherapy and radiotherapy, will be reviewed and their results discussed. Many of these clinical studies are being conducted by centres in the UK.
authors.affiliation: Department of Oncology, Postgraduate Medical School, University of Surrey, Guildford, UK. c.comins@surrey.ac.uk
authors.forename: C
authors.initials: C
authors.lastname: Comins
authors.forename: L
authors.initials: L
authors.lastname: Heinemann
authors.forename: K
authors.initials: K
authors.lastname: Harrington
authors.forename: A
authors.initials: A
authors.lastname: Melcher
authors.forename: J
authors.initials: J
authors.lastname: De Bono
authors.forename: H
authors.initials: H
authors.lastname: Pandha
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D050130:Oncolytic Virotherapy / Q000379:methods / Q000639:trends*; D030102:Orthoreovirus, Mammalian / Q000235:genetics / Q000254:growth & development / Q000502:physiology*