Ring-closing metathesis in the synthesis of BC ring-systems of taxol.
BC ring-systems of taxol with different or no protecting group for the C1,C2-diol moiety have been efficiently synthesized. The eight-membered B ring is formed by a ring-closing metathesis reaction (RCM) between the C10 and C11 carbon atoms. The influence of the 1,2-diol protecting group on the RCM reaction has been studied in detail.
Ma
Cong
C
Laboratoire de Synthèse Organique, CNRS UMR 7652, Ecole Polytechnique, DCSO, Palaiseau Cedex, France.
Schiltz
Stéphanie
S
Le Goff
Xavier F
XF
Prunet
Joëlle
J
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D017239:Paclitaxel / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel