Birth weight [corrected] and elevated albumin to creatinine ratio in youth with diabetes: the SEARCH for Diabetes in Youth study.
Low birth weight (BWT) may contribute to kidney disease and could explain some of the variance in the development of early diabetic kidney disease. This hypothesis was tested in the multicenter SEARCH study (3,714 youth with diabetes <20 years of age). A morning spot urine sample, laboratory and anthropometric data, and a medical history were obtained. Elevated albumin to creatinine ratio (ACR) was defined as > or =30 mcg albumin/mg creatinine, and BWT was categorized as low (<2,500 g), reference (2,500-4,000 g), or high (>4,000 g). The relationship of BWT to elevated ACR was analyzed using multiple logistic regression. In youth with diabetes, the prevalence of elevated ACR was 12.6% in those with low BWT, 9.7% in those with reference BWT, and 8.9% in those with high BWT. BWT category was not significantly associated with elevated ACR (p = 0.23). Those with diabetes duration >18 months (2,032) had the following association of BWT category with elevated ACR [odds ratio (OR) = 1.64, 95% confidence interval (CI) 1.00-2.69, p = 0.0503] for low BWT compared with reference BWT. Whereas low BWT may be a factor in kidney disease, little evidence was found of a relationship between low BWT and elevated ACR in this study population of youth with diabetes.
Maahs
David M
DM
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA, David.Maahs@uchsc.edu.
Snively
Beverly M
BM
Beyer
Jennifer
J
Imperatore
Giuseppina
G
Bell
Ronny
R
Mayer-Davis
Elizabeth J
EJ
Dolan
Lawrence M
LM
Pettitt
David J
DJ
Hirsch
Irl
I
Rodriguez
Beatriz
B
Dabelea
Dana
D
D000293:Adolescent; D000419:Albuminuria / Q000453:epidemiology* / Q000503:physiopathology*; D001724:Birth Weight / Q000502:physiology*; D002648:Child; D003404:Creatinine / Q000652:urine*; D003430:Cross-Sectional Studies; D003625:Data Collection; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000503:physiopathology / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology / Q000652:urine; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight / Q000502:physiology / Q000652:urine; D007231:Infant, Newborn; D007407:Interviews as Topic; D016015:Logistic Models; D008297:Male; D015995:Prevalence; D012307:Risk Factors
D003404:Creatinine