Finite scale of spatial representation in the hippocampus.
To determine how spatial scale is represented in the pyramidal cell population of the hippocampus, we recorded neural activity at multiple longitudinal levels of this brain area while rats ran back and forth on an 18-meter-long linear track. CA3 cells had well-defined place fields at all levels. The scale of representation increased almost linearly from <1 meter at the dorsal pole to approximately 10 meters at the ventral pole. The results suggest that the place-cell map includes the entire hippocampus and that environments are represented in the hippocampus at a topographically graded but finite continuum of scales.
Kjelstrup
Kirsten Brun
KB
Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
Solstad
Trygve
T
Brun
Vegard Heimly
VH
Hafting
Torkel
T
Leutgeb
Stefan
S
Witter
Menno P
MP
Moser
Edvard I
EI
Moser
May-Britt
MB
D000200:Action Potentials; D000465:Algorithms; D000818:Animals; D001931:Brain Mapping; D004567:Electrodes, Implanted; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D007858:Learning; D016014:Linear Models; D008297:Male; D017966:Pyramidal Cells / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D013028:Space Perception; D013037:Spatial Behavior; D013826:Theta Rhythm