title: Influence of local anesthethics with adrenalina 1:100.000 in basic vital constants during third molar surgery.
abstract: OBJECTIVE
  The present study consists of a double-blind randomized clinical trial of paired samples. The purpose of the present study was thus to examine the effect of four different local anesthetics of the amida group (2% lidocaine with 1:100.000 adrenaline; 3% prilocaine with 0.30 IU felipressine; 2% mepivacaine with 1:100.000 adrenaline; and 4% articaine with 1:100.100 adrenaline) in patients undergoing extraction of lower third molars and verify the changes in systolic, diastolic and mean blood pressures, heart rate (HR) and oxygen saturation (SpO2).
  
  
  METHODS
  The sample comprised 168 extractions of lower third molars performed on 84 patients, divided into three groups, in whom lidocaine was the control anesthetic. The anesthetic solution applied differed from one side of the mouth to the other (control and experimental) in the same patient at different time periods.
  
  
  RESULTS
  The following significant variations were observed: increase in systolic blood pressure with mepivacaine and articaine; decrease in diastolic blood pressure with lidocaine; increase in heart rate with all the anesthetics, but with no statistical significance in the case of prilocaine. The variations in mean blood pressure and oxygen saturation were not statistically significant. All the hemodynamic changes returned to normal with no need for any further treatment. No complications were observed in any of the 168 procedures performed.
  
  
  CONCLUSIONS
  All the anesthetics studied behaved, in relation to lidocaine, within the parameters of hemodynamic safety, although the best performance was that of prilocaine, followed by lidocaine. The measurement of systolic blood pressure, diastolic blood pressure and heart rate are appropriate monitoring methods for patients under the effects of local anesthetic, even healthy ones.
authors.affiliation: School of Dentistry, State University of Pernambuco, Camaragibe, Brazil.
authors.forename: Ricardo José de Holanda
authors.initials: RJ
authors.lastname: Vasconcellos
authors.forename: Belmiro Cavalcanti do Egito
authors.initials: BC
authors.lastname: Vasconcelos
authors.forename: Paloma Rodrigues
authors.initials: PR
authors.lastname: Genú
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D004837:Epinephrine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008964:Molar, Third; D009200:Myocardial Contraction / Q000187:drug effects; D010100:Oxygen / Q000378:metabolism; D014081:Tooth Extraction
chemical_list: D000779:Anesthetics, Local; D010100:Oxygen; D004837:Epinephrine