Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway.
The Human papillomavirus plays an important role in the initiation and progression of cervical cancer. However, it is a necessary but not sufficient cause to develop invasive carcinoma; hence, other factors are required in the pathogenesis of this malignancy. In this review we explore the hypothesis of the deregulation of wnt/beta-catenin signaling pathway as a "second hit" required to develop cervical cancer.
Perez-Plasencia
Carlos
C
Unidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas, Universidad Nacional Autonóma de Mexico UNAM, Instituto Nacional de Cancerologa INCAN, Mexico City, Mexico. car_plas@yahoo.com.
Duenas-Gonzalez
Alfonso
A
Alatorre-Tavera
Brenda
B