The effectiveness of measuring for fragmented red cells using an automated hematology analyzer in patients with thrombotic microangiopathy.
Thrombotic microangiopathy (TMA) or thrombotic thrombocytopenic purpura (TTP) is a life-threatening syndrome characterized by increased number of fragmented red cells (FRCs) and thrombocytopenia. FRCs can be measured using the recently developed automated hematology analyzer XE-2100. The normal range for FRCs is 0% to 0.205%, as determined by the automated hematology analyzer XE-2100. The FRC count is significantly elevated in patients with TMA associated with liver transplantation, bone marrow transplantation, or TTP. In patients with TMA after liver transplantation, the FRC count is significantly higher than in those without TMA. In receiver operating characteristic analysis for the diagnosis of TMA, the area under the curve is 0.986, suggesting that FRC is a useful marker for the diagnosis of TMA. When the cutoff value of FRC for TMA is 1.2%, the sensitivity is 90% and the specificity is 96%, indicating that FRC is the most useful screening test for the diagnosis of TMA.
Abe
Yasunori
Y
Central Laboratory, Mie University Graduate School of Medicine, Tsu, Japan.
Wada
Hideo
H
Yamada
Eri
E
Noda
Maki
M
Ikejiri
Makoto
M
Nishioka
Junji
J
Kobayashi
Toshihiko
T
Matsumoto
Takeshi
T
Masuya
Masahiro
M
Isaji
Syuji
S
Usui
Masanobu
M
Uemoto
Sinji
S
Katayama
Naoyuki
N
Nobori
Tsutomu
T
D000328:Adult; D000368:Aged; D000743:Anemia, Hemolytic / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D001331:Automation; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D016022:Case-Control Studies; D002648:Child; D004906:Erythrocyte Count / Q000295:instrumentation*; D004912:Erythrocytes / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry / Q000295:instrumentation*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013997:Time Factors; D055815:Young Adult