Impact of antiretroviral therapy on chemokine (C-C motif) receptor 5 expression in HIV patients followed for over 2 years.
Suppression of HIV replication using highly active antiretroviral therapy (HAART) might influence chemokine (C-C motif) receptor 5 expression on infected cells and therefore modulate the activity of chemokine (C-C motif) receptor 5 antagonists. Chemokine (C-C motif) receptor 5 expression was examined longitudinally in 26 HIV-infected adults who initiated HAART. Long-term suppression of plasma HIV-RNA did not significantly influence chemokine (C-C motif) receptor 5 expression on T lymphocytes. Therefore, the activity of chemokine (C-C motif) receptor 5 antagonists should not differ before and following HIV suppression on HAART.
Briz
Verónica
V
Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain.
Poveda
Eva
E
López
Mariola
M
González
María Del Mar
Mdel M
Soriano
Vincent
V
Benito
José Miguel
JM
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D019713:Receptors, CCR5 / Q000097:blood*
D019380:Anti-HIV Agents; D019713:Receptors, CCR5