Synthesis and evaluation of antitubercular activity of glycosyl thio- and sulfonyl acetamide derivatives.
A series of glycosyl thioacetamide and glycosyl sulfonyl acetamide derivatives have been prepared following a convenient reaction protocol and evaluated for their antitubercular activity against Mycobacterium tuberculosis H(37)Rv. Amongst 32 compounds evaluated 3 compounds were effective in inhibiting mycobacterial growth at MIC of 6.25 microg/mL, 6 compounds at MIC of 3.125 microg/mL and 1 compound at MIC of 1.56 microg/mL. All active compounds were found nontoxic in Vero cell lines and mice bone marrow macrophages.
Ghosh
Samir
S
Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226001, UP, India.
Tiwari
Pallavi
P
Pandey
Shashi
S
Misra
Anup Kumar
AK
Chaturvedi
Vinita
V
Gaikwad
Anil
A
Bhatnagar
Shalini
S
Sinha
Sudhir
S
D000081:Acetamides / Q000737:chemistry*; D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000166:cytology*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002522:Chlorocebus aethiops; D015195:Drug Design; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D014376:Tuberculosis / Q000188:drug therapy; D014709:Vero Cells
D000081:Acetamides; D000995:Antitubercular Agents