title: Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand.
abstract: KRN7000 is an important ligand identified for CD1d protein of APC, and KRN7000/CD1d complex can stimulate NKT cells to release Th1 and Th2 cytokines. In an effort to understand the structure-activity relationships, we have carried out the synthesis of a complete set of the eight KRN7000 stereoisomers, and their biological activities have been examined.
authors.affiliation: Department of Chemistry, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
authors.forename: Jeong-Ju
authors.initials: JJ
authors.lastname: Park
authors.forename: Ji Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Ghosh
authors.forename: Gabriel
authors.initials: G
authors.lastname: Bricard
authors.forename: Manjunatha M
authors.initials: MM
authors.lastname: Venkataswamy
authors.forename: Steven A
authors.initials: SA
authors.lastname: Porcelli
authors.forename: Sung-Kee
authors.initials: SK
authors.lastname: Chung
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000737:chemistry; D018949:Antigens, CD1 / Q000737:chemistry* / Q000378:metabolism; D055610:Antigens, CD1d; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D005699:Galactosylceramides / Q000138:chemical synthesis* / Q000737:chemistry*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D008024:Ligands; D008956:Models, Chemical; D011485:Protein Binding; D013237:Stereoisomerism
chemical_list: D000276:Adjuvants, Immunologic; D018949:Antigens, CD1; D055610:Antigens, CD1d; C526877:CD1D protein, human; D005699:Galactosylceramides; D008024:Ligands; C493154:alpha-galactosylceramide; C103873:KRN 7000