title: [Effects of lipid dysmetabolism in rats induced by high fat diet on glycometabolism and inflammatory factor].
abstract: OBJECTIVE
  To investigate the changes of glycometabolism and inflammatory factors of the lipid dysmetabolism in rats induced by high fat diet.
  
  
  METHODS
  20 male SD rats were divided into the control group and the lipid dysmetabolism group. The rats were administrated the high fat diet for 17 weeks, then body weight, and the contents of TC, TG, HDL-C, TNF-alpha and IL-6 were measured, and the contents of serum FPG, FINS and hs-CRP were detected at the 5th, 11th and 17th weeks respectively.
  
  
  RESULTS
  In comparison with the control groups, the serum contents of TC, TG, FINS, hs-CRP and IL-6 were increased significantly in the lipid dysmetabolism groups, and the ISI levels were decreased in thelipid dysmetabolism groups (P < 0.05).
  
  
  CONCLUSIONS
  The rats were induced by high fat diet to develope the lipid dysmetabolism, the lipid dysmetabolism could induce of the FINS increases and decreases of the ISI.
authors.affiliation: School of Public Health, Southeast University, Nanjing 210009, China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Wang
authors.forename: Chengkai
authors.initials: C
authors.lastname: Zhai
authors.forename: Han
authors.initials: H
authors.lastname: Chen
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D044882:Glucose Metabolism Disorders / Q000378:metabolism*; D006949:Hyperlipidemias / Q000209:etiology / Q000378:metabolism*; D007328:Insulin / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004041:Dietary Fats; D007328:Insulin; D015850:Interleukin-6; D002097:C-Reactive Protein