Synthesis, characterization, and the antioxidative activity of 4-{[(3,4-dimethyl pyrrole-2-carbonyl)hydrazono](phenyl)methyl}-3-methyl-1-phenylpyrazol-5-ol and Its zinc(II), copper(II), nickel(II) complexes.
A new ligand H(3)L, 4-{[(3,4-dimethylpyrrole-2-carbonyl)hydrazono](phenyl)methyl}-3-methyl-1-phenylpyrazol-5-ol and its three transition metal complexes, M(H(2)L)OAc.H(2)O (M=Cu, Ni), Zn(H(2)L)(2) have been synthesized and fully characterized on the basis of ESI-MS, elemental analyses, molar conductivities, IR spectra and (1)H-NMR. In addition, their antioxidative activities have been investigated by spectrophotometer measurements. The experimental results show that the complexes have higher activity in the suppression of O(2)(*-) and *OH than the free ligand.
Wang
Qian
Q
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, PR China.
Wang
Yuan
Y
Yang
Zheng-Yin
ZY
D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003300:Copper; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000378:metabolism; D009532:Nickel; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013481:Superoxides / Q000378:metabolism; D015032:Zinc
C530553:4-(((3,4-dimethyl pyrrole-2-carbonyl)hydrazono)(phenyl)methyl)-3-methyl-1-phenylpyrazol-5-ol; D000975:Antioxidants; D016166:Free Radical Scavengers; D006834:Hydrazines; D009942:Organometallic Compounds; D011720:Pyrazoles; D011758:Pyrroles; D013481:Superoxides; D017665:Hydroxyl Radical; D003300:Copper; D009532:Nickel; D015032:Zinc