Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction.
Coronary artery disease (CAD) and myocardial infarction (MI) have a genetic basis, but the precise genetic underpinning remains controversial. Recently, an association of the LRP8 R952Q polymorphism (rs5174) with familial premature CAD/MI was reported. We analysed rs5174 (or the perfect proxy rs5177) in 1,210 patients with familial MI and 1,015 controls from the German MI Family study, in 1,926 familial CAD (1,377 with MI) patients and 2,938 controls from the Wellcome Trust Case Control Consortium (WTCCC) MI/CAD cohort, in 346 CAD patients and 351 controls from the AtheroGene study and in 295 men with incident CAD and 301 controls from the Prospective Epidemiological Study of MI study and found no evidence for association in any of the populations studied. In the WTCCC and the German MI Family studies, additional single-nucleotide polymorphisms in the LRP8 gene were analysed and displayed no evidence for association either.
Lieb
Wolfgang
W
Medizinische Klinik II, Universität zu Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
Zeller
Tanja
T
Mangino
Massimo
M
Götz
Anika
A
Braund
Peter
P
Wenzel
Juergen J
JJ
Horn
Christian
C
Proust
Carole
C
Linsel-Nitschke
Patrick
P
Amouyel
Philippe
P
Bruse
Petra
P
Arveiler
Dominique
D
König
Inke R
IR
Ferrières
Jean
J
Ziegler
Andreas
A
Balmforth
Anthony J
AJ
Evans
Alun
A
Ducimetière
Pierre
P
Cambien
Francois
F
Hengstenberg
Christian
C
Stark
Klaus
K
Hall
Alistair S
AS
Schunkert
Heribert
H
Blankenberg
Stefan
S
Samani
Nilesh J
NJ
Erdmann
Jeanette
J
Tiret
Laurence
L
D003324:Coronary Artery Disease / Q000235:genetics*; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D005858:Germany; D006801:Humans; D026502:LDL-Receptor Related Proteins; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018110:Receptors, Lipoprotein / Q000235:genetics*
D026502:LDL-Receptor Related Proteins; D018110:Receptors, Lipoprotein; C098773:low density lipoprotein receptor-related protein 8