Network models in drug discovery and regenerative medicine.
Network motifs and modelling paradigms are attracting increasing attention as modelling tools in drug design and development, and in regenerative medicine. There is a gradual but inexorable convergence between these hitherto disparate disciplines. This review summarizes some very recent work in these areas, leading to an understanding of the complementary roles networks play and factors driving this convergence: network paradigms can be excellent ways of modelling and understanding drug molecules and their action, an understanding of the robustness and vulnerabilities of biological targets may improve the efficacy of drug design and discovery, drug design has an increasingly large role to play in directing stem cell properties, stem cell regulatory networks can be modelled in useful ways using network models at a reasonable level of scale, and the network tools of drug design are also very useful for the design of biomaterials used in regenerative medicine.
Winkler
David A
DA
CSIRO Molecular and Health Technologies, Clayton 3168, Australia. dave.winkler@csiro.au
D000818:Animals; D003198:Computer Simulation; D015195:Drug Design; D006801:Humans; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D020543:Proteome / Q000378:metabolism*; D012038:Regeneration / Q000187:drug effects / Q000502:physiology*; D044968:Regenerative Medicine / Q000379:methods* / Q000639:trends*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D004364:Pharmaceutical Preparations; D020543:Proteome