title: Effects of various amino acids on methionine-induced hyperhomocysteinemia in rats.
abstract: Rats were fed diets supplemented with 1% L-methionine with and without 2.5% various amino acids for 7 d to determine what amino acids other than glycine, serine, and cystine can suppress methionine-induced hyperhomocysteinemia. L-Glutamic acid, L-histidine, and L-arginine significantly suppressed methionine-induced enhancement of plasma homocysteine concentrations, but the mechanisms underlying the effect of these amino acids are thought not to be identical.
authors.affiliation: Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka, Japan.
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Fukada
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Morita
authors.forename: Kimio
authors.initials: K
authors.lastname: Sugiyama
mesh_terms: D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001120:Arginine / Q000494:pharmacology; D019587:Dietary Supplements; D018698:Glutamic Acid / Q000494:pharmacology; D006639:Histidine / Q000494:pharmacology; D006710:Homocysteine / Q000097:blood; D020138:Hyperhomocysteinemia / Q000139:chemically induced / Q000188:drug therapy*; D008715:Methionine; D051381:Rats
chemical_list: D000596:Amino Acids; D006710:Homocysteine; D018698:Glutamic Acid; D006639:Histidine; D001120:Arginine; D008715:Methionine