title: TEQ(S) and body burden for PCDDs, PCDFs, and dioxin-like PCBs in human adipose tissue.
abstract: Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), mono-ortho and non-ortho polychlorinated biphenyls (dioxin-like PCBs) were determined in samples of human fat tissue from nine Italian obese patients. The toxicity equivalent (TEQ) values ranged from 9 to 25 pg TEQ g(-1) lipid (WHO-TEF values, 2005 [Van den Berg, M., Birnbaum, L.S., Denison, M., De Vito, M., Farland, W., Feeley, M., Fiedler, H., Hakansson, H., Hanberg, A., Haws, L., Rose, M., Safe, S., Schrenk, D., Tohyama, C., Tritscher, A., Tuomisto, J., Tysklind, M., Walker, N., Peterson, R.E., 2006. The 2005 World Health Organization reevaluation of human and mammalian Toxic Equivalency Factors for dioxins and dioxin-like compounds. Toxicol. Sci. 93, 223-241]), the contribution of dioxin-like PCBs was more than 30% of the total TEQ values. The obese body burdens varied from 6 to 11 ng TEQ kg(-1) body weight (BW), exceeding the estimated steady-state body burden 5 ng TEQ kg(-1) BW, based on lipid adjusted serum concentrations from several populations in the mid-1990s, calculated in the risk assessment US EPA document.
authors.affiliation: Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. cinzia.larocca@iss.it
authors.forename: Cinzia
authors.initials: C
authors.lastname: La Rocca
authors.forename: Silvia
authors.initials: S
authors.lastname: Alivernini
authors.forename: Marco
authors.initials: M
authors.lastname: Badiali
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cornoldi
authors.forename: Nicola
authors.initials: N
authors.lastname: Iacovella
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Silvestroni
authors.forename: Giovanni
authors.initials: G
authors.lastname: Spera
authors.forename: Luigi
authors.initials: L
authors.lastname: Turrio-Baldassarri
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D001572:Benzofurans / Q000032:analysis* / Q000633:toxicity; D001822:Body Burden; D001835:Body Weight; D000072338:Dibenzofurans, Polychlorinated; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000032:analysis* / Q000633:toxicity; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000209:etiology; D011078:Polychlorinated Biphenyls / Q000032:analysis* / Q000633:toxicity; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis / Q000633:toxicity; D012989:Soil Pollutants / Q000032:analysis / Q000633:toxicity
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D012989:Soil Pollutants; D011078:Polychlorinated Biphenyls