title: C-H Bond Functionalizations with Palladium(II): Intramolecular Oxidative Annulations of Arenes.
abstract: Oxidative annulations for the synthesis of carbocycles were developed using a catalytic palladium(II) system. Indoles with pendant olefin tethers were oxidatively cyclized to form annulated products. Electron-rich aromatic systems were also investigated, culminating in the synthesis of benzofurans and dihydrobenzofurans by a similar protocol. These reactions were demonstrated to proceed by an initial C-H bond functionalization event, followed by olefin insertion and β-hydride elimination.
authors.affiliation: The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Ferreira
authors.forename: Haiming
authors.initials: H
authors.lastname: Zhang
authors.forename: Brian M
authors.initials: BM
authors.lastname: Stoltz