Behavioral and pathological outcomes in MOG 35-55 experimental autoimmune encephalomyelitis.
We measured inflammatory and neural markers of disease from 7 days to one year after induction of experimental autoimmune encephalomyelitis (EAE) by immunization with myelin oligodendrocyte glycoprotein (MOG) peptide. Axon loss began before behavioral signs when T cell infiltration and microglial activation were very subtle. Remyelination was only detectable ultrastructurally. Axon numbers in the dorsal column plateau around day 30 p.i. while behavioral measures (EAE scores, rotarod, grip strength) partially recover. These results provide a starting point for testing potential neuroprotective treatments for multiple sclerosis (MS).
Jones
M V
MV
Johns Hopkins University, Department of Neurology, 600 N. Wolfe Street, Pathology Bldg Room 6-27, Baltimore, Maryland 21287, USA.
Nguyen
T T
TT
Deboy
C A
CA
Griffin
J W
JW
Whartenby
K A
KA
Kerr
D A
DA
Calabresi
P A
PA
D000818:Animals; D001522:Behavior, Animal; D018450:Disease Progression; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D007150:Immunohistochemistry; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000276:immunology; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments / Q000276:immunology*; D020127:Recovery of Function; D013116:Spinal Cord / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D013995:Time
D006023:Glycoproteins; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; C445081:myelin oligodendrocyte glycoprotein (35-55)