Subcortical interactions between somatosensory stimuli of different modalities and their temporal profile.
Interactions between inputs of different sensory modality occur along the sensory pathway, including the thalamus. However, the temporal profile of such interaction has not been fully studied. In eight patients who had been implanted an intrathalamic electrode for deep brain stimulation as symptomatic treatment of tremor, we investigated the interactions between mechanical taps and electrical nerve stimuli. Somatosensory evoked potentials (SEPs) were recorded from Erb's point, cervical spinal cord, nucleus ventrointermedialis of the thalamus, and parietal cortex. A handheld electronic reflex hammer was used to deliver a mechanical tap to the skin overlying the first dorsal interosseous muscle and to trigger an ipsilateral digital median nerve electrical stimulus time-locked to the mechanical tap with a variable delay of 0 to 50 ms. There were significant time-dependent interactions between the two sensory volleys at the subcortical level. Thalamic SEPs were decreased in amplitude at interstimulus intervals (ISIs) from 10 to 40 ms with maximum effect at 20 ms (-42.8 +/- 10.5%; P < 0.001). A similar decrease was also seen in the number and frequency of the high-frequency components of thalamic SEPs (-25 +/- 4%). A smaller reduction (-18.1 +/- 5.8%; P < 0.001) was present in upper cervical response at ISI = 20 ms. There were no changes in peripheral responses. Cortical SEPs were almost completely absent in some subjects at ISIs from 20 to 50 ms. There were no changes in SEP latencies. Our results indicate that significant time-dependent interactions between sensory volleys occur at the subcortical level. These observations provide further insight into the physiological mechanisms underlying afferent gating between sensory volleys of different modality.
Costa
João
J
Electromyography and Motor Control Unit, Neurology Department, Institut d'Investigació Biomèdica August Pi i Sunyer, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
Valls-Solé
Josep
J
Valldeoriola
Francesc
F
Rumià
Jordi
J
D000344:Afferent Pathways / Q000503:physiopathology*; D000368:Aged; D000704:Analysis of Variance; D001931:Brain Mapping; D046690:Deep Brain Stimulation / Q000379:methods; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000503:physiopathology / Q000528:radiation effects; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology; D010812:Physical Stimulation; D011930:Reaction Time / Q000502:physiology; D012867:Skin / Q000294:innervation; D013788:Thalamus / Q000473:pathology / Q000503:physiopathology*; D013997:Time Factors; D014202:Tremor / Q000473:pathology / Q000503:physiopathology