title: Pharmacokinetics-pharmacodynamics of quinolones against Streptococcus pneumoniae in patients with community-acquired pneumonia.
abstract: Exposure-response analyses were performed using data from 89 patients (10 clinical trials) with Streptococcus pneumoniae community-acquired pneumonia who received quinolones. Relationships between the free-drug AUC/MIC ratio and clinical and microbiologic response were identified. Such data may be useful to establish prior expectations for the no-treatment effect when conducting noninferiority clinical trials.
authors.affiliation: Institute for Clinical Pharmacodynamics, Ordway Research Institute, Albany, NY 12206-1072, USA. sbhavnani-icpd@ordwayresearch.org
authors.forename: Sujata M
authors.initials: SM
authors.lastname: Bhavnani
authors.forename: Alan
authors.initials: A
authors.lastname: Forrest
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Hammel
authors.forename: George L
authors.initials: GL
authors.lastname: Drusano
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Rubino
authors.forename: Paul G
authors.initials: PG
authors.lastname: Ambrose
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D019540:Area Under Curve; D017714:Community-Acquired Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D015363:Quinolones / Q000493:pharmacokinetics / Q000627:therapeutic use; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D015363:Quinolones