Enterovirus 71 in Taiwan, 2004-2006: epidemiological and virological features.
We report unusual cases of myocarditis caused by enterovirus 71 (EV71) and a declining trend in the incidence of EV71 in Taiwan since 2005. Furthermore, phylogenetic analysis of the 5' untranslated region, VP4, and VP1 genes of EV71 isolates in 2004-2005 revealed a divergent phylogeny from the previous Taiwanese isolates. No obvious phylogenetically distinct clones or clusters were found related to varying degrees of disease severity or clinical manifestations.
Huang
Kuan-Ying
KY
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Zhang
Xiaowei
X
Chung
Po-How
PH
Tsao
Kuo-Chien
KC
Lin
Tzou-Yien
TY
Su
Lin-Hui
LH
Chiu
Cheng-Hsun
CH
D020121:5' Untranslated Regions; D002675:Child, Preschool; D016000:Cluster Analysis; D029821:Enterovirus A, Human / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000453:epidemiology* / Q000821:virology*; D005260:Female; D006801:Humans; D009205:Myocarditis / Q000453:epidemiology / Q000821:virology; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013624:Taiwan / Q000453:epidemiology; D014764:Viral Proteins / Q000235:genetics
D020121:5' Untranslated Regions; D012367:RNA, Viral; D014764:Viral Proteins