Late occurrence of pleural and peritoneal effusion due to Mycobacterium tuberculosis infection (TB) in a patient with posttransplantation recurrent HCV chronic hepatitis: safety of peginterferon and ribavirin treatment after recovery of TB:- a case report.
The late occurrence of a large and often long-lasting effusion in the pleural and peritoneal cavities after liver transplantation is an uncommon and poorly understood complication. Even rarer (<1%) is the incidence of Mycobacterium tuberculosis (MT) in Western world series. Herein we have described a case of massive pleural effusion and ascites due to MT occurring 22 months after liver transplantation for hepatitis C virus (HCV) cirrhosis. The infection was successfully treated with no hepatotoxicity or rejection, so that it was possible to start antiviral treatment with peginterferon and ribavirin for recurrent HCV without reactivation of MT infection.
Grasso
A
A
Internal Medicine and Gastroenterology Unit, San Paolo Hospital, Savona, Italy. a.grasso@asl2.liguria.it
De Leo
P
P
Malfatti
F
F
Toscanini
F
F
Anselmo
M
M
Menardo
G
G
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D001202:Ascitic Fluid / Q000382:microbiology*; D006526:Hepatitis C / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008103:Liver Cirrhosis / Q000601:surgery / Q000821:virology; D016031:Liver Transplantation; D008297:Male; D009169:Mycobacterium tuberculosis; D010996:Pleural Effusion / Q000382:microbiology*; D011183:Postoperative Complications; D012254:Ribavirin / Q000627:therapeutic use*; D012449:Safety; D016896:Treatment Outcome; D014376:Tuberculosis / Q000175:diagnosis*
D000998:Antiviral Agents; D016898:Interferon-alpha; D012254:Ribavirin