Oxidative stress markers, C-reactive protein and heat shock protein 70 levels in subjects with metabolic syndrome.
BACKGROUND
The metabolic syndrome is a cluster of cardiovascular risk factors and essential components of metabolic syndrome are hyperglycemia, hypertension, visceral obesity, hypertriglyceridemia and low high-density lipoprotein cholesterol. Oxidative stress plays a critical role in the pathogenesis of metabolic syndrome components and insulin resistance. The aim of this study was to investigate the role of oxidative stress, C-reactive protein and heat shock protein 70 levels in the pathogenesis of this disease.


METHODS
A total of 36 patients diagnosed with metabolic syndrome and 33 controls were included in the study. Malondialdehyde, carbonyl protein, C-reactive protein and heat shock protein 70 levels and xanthine oxidase and superoxide dismutase activities were measured in the serum of the subjects.


RESULTS
Mean serum malondialdehyde, carbonyl protein, C-reactive protein (p<0.01, p<0.05 and p<0.001, respectively) and xanthine oxidase activity were significantly higher (p<0.01) in serum of the patients than the control group. Superoxide dismutase activity and heat shock protein 70 levels were significantly lower (p<0.01 and p<0.05, respectively) in serum of the patients.


CONCLUSIONS
These results suggest that oxidative stress parameters and components of metabolic syndrome are closely related; therefore, significant alterations may occur in the antioxidant and inflammatory status. However, further studies are required to evaluate the possible molecular mechanisms of heat shock protein 70 levels in metabolic syndrome.
Armutcu
Ferah
F
Department of Biochemistry, Canakkale Onsekiz Mart University Medical Faculty, Canakkale, Turkey. drferah@yahoo.com
Ataymen
Meryem
M
Atmaca
Hulusi
H
Gurel
Ahmet
A
D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood*; D014969:Xanthine Oxidase / Q000097:blood*
D018840:HSP70 Heat-Shock Proteins; D008315:Malondialdehyde; D002097:C-Reactive Protein; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase