Low-pressure airlift fermenter for single cell protein production: II. Continuous culture of pichia yeast.
Experiments using Pichia yeast grown on n-paraffins have been conducted in laboratory 10-L airlift fermenters and in a 640-L module of commercial scale. Results confirmed the design concept of combining oxygen transfer and fermenter cooling with low-pressure air. However, in the absence of mass transport constraints, the build up of toxic factors in the fermenter appeared to be a major variable limiting cell productivity. Foaming in the large fermenter also presented a serious problem, which must be solved before low-pressure airlift fermenters become practical.
Chen
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Mobil Research and Development Corporation, Central Research Laboratory, P.O. Box 1025, Princeton, NJ 08540.
Srinivasan
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Leavitt
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Coty
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Kondis
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