[Acute necrotizing pancreatitis and postmortem autolysis of pancreas].
OBJECTIVE
To compare the pathomorphologic changes between the pancreas in acute necrotizing pancreatitis (ANP) and that in acute deaths of rats (within 48 hours) so as to find the distinctions.


METHODS
The animal models of ANP and other acute deaths (electroshock, mechanic asphyxia/strangle, and acute poisoning with tetramine) were established according to the criteria. Half-quantitative grading and image quantitative analysis methods were employed to observe the gross and microscopic changes of the pancreases.


RESULTS
Three features including inflammation infiltrate, fat necrosis and calcium deposit in the ANP group were considerably different from that in other acutely died rat group (P<0.05).


CONCLUSIONS
Inflammation infiltrate, fat necrosis and calcium deposit are the most important pathologic features found in ANP by common light microscope, distinguishing ANP from postmortem pancreatic autolysis.
Ye
Guang-Hua
GH
Department of Forensic Medicine, Wenzhou Medical College, Wenzhou 325035, China. yeghua345@126.com
Zhang
Yi-Gu
YG
Yu
Lin-Sheng
LS
Li
Xing-Biao
XB
Han
Jun-Ge
JG
D000818:Animals; D001329:Autolysis; D005260:Female; D049429:Forensic Pathology; D008297:Male; D010179:Pancreas / Q000473:pathology*; D019283:Pancreatitis, Acute Necrotizing / Q000473:pathology*; D011041:Poisoning / Q000473:pathology*; D011180:Postmortem Changes; D051381:Rats; D017207:Rats, Sprague-Dawley