The impact of admission C-reactive protein levels on the development of no-reflow phenomenon after primary PCI in patients with acute myocardial infarction: the role of inflammation.
The role of admission CRP levels on the prediction of poor myocardial perfusion grades after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) has not been clearly elucidated. Dynamic nature of acute coronary syndromes is usually associated with spontaneous ischemia-reperfusion injury in infarct related artery. So we considered that poor myocardial perfusion after primary PCI is not only related to procedural factors and clinical characteristics of the patients but may also be related to microvascular damage starting before coronary intervention. We suggested that CRP mediated complement activation and neutrophil plugging may be the factors contributing to the development of microvascular damage in patients with AMI.
Celik
Turgay
T
Iyisoy
Atila
A
Yuksel
U Cagdas
UC
Jata
Bekim
B
Ozkan
Mustafa
M
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D002097:C-Reactive Protein / Q000032:analysis*; D003955:Diagnostic Tests, Routine / Q000592:standards*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood / Q000502:physiology*; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000175:diagnosis; D054318:No-Reflow Phenomenon / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D011237:Predictive Value of Tests
D018836:Inflammation Mediators; D002097:C-Reactive Protein