title: Therapeutic challenges in the management of gout in the elderly.
abstract: Gout is the most common inflammatory arthritis in the elderly population. Management in the elderly requires special consideration. Physiologic changes associated with aging and co-morbidities make the elderly prone to adverse effects of drugs otherwise successfully used in younger counterparts. Use of colchicine, non-steroidal anti-inflammatory drugs, and urate-lowering therapies may be restricted in those with limited renal reserve. Corticosteroids are safe alternatives for short-term use in acute gout. Elderly patients need laboratory monitoring for side effects more frequently than usual. Non-pharmacologic measures such as dietary modifications, regular exercise, and ice therapy should be considered vital adjunctive treatments. A brief review of future therapies is also discussed.
authors.affiliation: Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, USA.
authors.forename: Harinder
authors.initials: H
authors.lastname: Singh
authors.forename: Karina D
authors.initials: KD
authors.lastname: Torralba
mesh_terms: D000368:Aged; D005260:Female; D005853:Geriatrics; D006073:Gout / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy*; D006074:Gout Suppressants / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male
chemical_list: D006074:Gout Suppressants