title: Empiric antibiotic therapy for acute osteoarticular infections with suspected methicillin-resistant Staphylococcus aureus or Kingella.
abstract: The bacterial agents causing bone and joint infections have been changing. Currently, methicillin-resistant Staphylococcus aureus (MRSA) and Kingella kingae are emerging pathogens. For treatment of MRSA infections, clindamycin, vancomycin, and linezolid are commonly prescribed antibiotics. Kingella are sensitive to most penicillins and cephalosporins. Because MRSA osteoarticular infections tend to be severe, longer periods of antibiotic treatment with more frequent monitoring of inflammatory markers are sometimes required to obtain a complete cure with no residual complications. To assist management, we have included a clinical decision tree with antibiotic treatment protocols.
authors.affiliation: Department of Pediatrics, Arrowhead Regional Medical Center, Colton, CA, USA.
authors.forename: Phisit
authors.initials: P
authors.lastname: Saphyakhajon
authors.forename: Avni Y
authors.initials: AY
authors.lastname: Joshi
authors.forename: W Charles
authors.initials: WC
authors.lastname: Huskins
authors.forename: Nancy K
authors.initials: NK
authors.lastname: Henry
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Boyce
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000627:therapeutic use; D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000188:drug therapy* / Q000382:microbiology; D002675:Child, Preschool; D003663:Decision Trees; D006801:Humans; D007223:Infant; D017881:Kingella / Q000145:classification / Q000187:drug effects*; D000069349:Linezolid; D016106:Methicillin Resistance; D016870:Neisseriaceae Infections / Q000188:drug therapy / Q000382:microbiology; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology; D023303:Oxazolidinones / Q000008:administration & dosage / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D014640:Vancomycin / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D014640:Vancomycin; D000069349:Linezolid