Involvement of hippocampal serotonin and neuropeptide Y in depression induced by chronic unpredicted mild stress.
Accumulated evidence indicates a role of the hippocampal 5-hydroxy-tryptamine (5-HT) and neuropeptide Y (NPY) in the response to stress and modulation of depression, but it is unclear whether and how the hippocampal 5-HT and NPY systems make contributions to chronic unpredicted mild stress (CUMS)-induced depression. Here we observed that rats receiving a variety of chronic unpredictable mild stressors for 3 weeks showed a variety of depression-like behavioral changes, including a significant reduction in body weight, sucrose preference, and locomotion, rearing and grooming in open field test, and a significant increase in immobility time in forced swimming test. These CUMS-induced behavioral changes were suppressed or blocked by intra-hippocampal injection of 5-HT (31.25 microg/microl) or NPY (10 microg/microl). These data suggest a critical role of reduced hippocampal 5-HT and NPY neurotransmission in CUMS-induced depression.
Luo
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DD
College of Life Science, Shaanxi Normal University, Xi'an, Shaanxi Province 710062, PR China.
An
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SC
Zhang
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X
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002908:Chronic Disease; D003866:Depressive Disorder / Q000209:etiology / Q000517:prevention & control* / Q000523:psychology; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005518:Food Preferences / Q000187:drug effects / Q000523:psychology; D006120:Grooming / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism*; D007103:Immobilization / Q000502:physiology / Q000523:psychology; D008297:Male; D008845:Microinjections / Q000379:methods; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D013315:Stress, Psychological / Q000150:complications*; D013550:Swimming / Q000523:psychology
D009478:Neuropeptide Y; D012701:Serotonin