[The use of NMP22 Bladder-Chek for the diagnosis and follow-up bladder cancer].
OBJECTIVE
The goal of this work is to evaluate the usefulness of NMP22 BladderChek in the diagnosis and follow-up of bladder cancer, comparing it with cystoscopy and urine cytology.


METHODS
Group 1: 109 asymptomatic patients on follow up for bladder cancer underwent cystoscopy, cytology and NMP22 BladderChek. Group 2:15 patients with history of hematuria underwent cystoscopy and NMP22 BladderChek.


RESULTS
Group 1: 9 patients had tumor relapse. Sensitivity was 25% for NMP22 test, 50% for citology and 100% for cystoscopy Specificity was 91.1%, 94.1% and 95% respectively. Group 2: 12 patients had bladder cancer. The sensitivity was of 83.3% for NMP22 BladderChek and 100% for cystoscopy. The specificity was of 100% for NMP22 BladderChek and 66.7% for cystoscopy.


CONCLUSIONS
The low sensitivity of NMP22 Bladder-Chek invalidates it as alternative method to cystoscopy in the follow-up of bladder cancer. But it can be recommended for screening in patients without history of bladder cancer but with an increased risk (smokers, patients with dysuria and hematuria).
Gonzalo Rodríguez
Victoria
V
Servicio de Urología, Hospital Clínico Universitario de Valladolid, Valladolid, España. victoriaCGR@hotmail.com
Sanz Justo
Lourdes
L
de Miguel Santamaría
Isabel
I
Martínez de Iturrate
Javier
J
Fernández del Busto
Ernesto
E
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000652:urine*; D002295:Carcinoma, Transitional Cell / Q000473:pathology; D003558:Cystoscopy; D003581:Cytodiagnosis; D005260:Female; D006417:Hematuria / Q000209:etiology / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000652:urine*; D011237:Predictive Value of Tests; D011934:Reagent Strips; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology
D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; D011934:Reagent Strips; C100379:nuclear matrix protein 22