Embryonal rhabdomyosarcoma of the chest wall: a case report and review of the literature.
Embryonal rhabdomyosarcoma is a soft-tissue sarcoma which has a predilection for the head and neck area, genitourinary tract and the extremities. We report a rare case of embryonal rhabdomyosarcoma of the chest wall in an 8-year-old girl, presenting as a destructive tumor in the rib and clinically and radiologically mimicking Ewing's sarcoma. Histopathological examination showed a small round cell tumor. Immunohistochemically, the positivity for muscle markers desmin and myogenin in the tumor cells proved to be useful for making a definitive diagnosis of embryonal rhabdomyosarcoma. Cytogenetic analysis revealed a high level of aneuploidy in the tumor cells, with double-minutes and additional chromosomal structural aberrations. The patient is responding well to chemotherapy.
Mysorekar
Vijaya V
VV
Department of Pathology, M. S. Ramaiah Medical College and Hospital, Bangalore, India. vijayamysorekar@yahoo.com
Harish
K
K
Kilara
Nalini
N
Subramanian
Murali
M
Giridhar
A G
AG
D000782:Aneuploidy; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D018233:Rhabdomyosarcoma, Embryonal / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D012512:Sarcoma, Ewing / Q000175:diagnosis; D013899:Thoracic Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D035441:Thoracic Wall / Q000473:pathology*