Cytotoxic activity and chemical reactivity of cis-platinum(II) and trans-palladium(II) complexes with diethyl (pyridinylmethyl)phosphates.
A series of square-planar platinum(II) and palladium(II) complexes of the formula cis-[PtCl2L2] and trans-[PdCl2L2] [L stands for diethyl (pyridin-2-ylmethyl)phosphate (2-pmOpe) or diethyl (pyridin-3-ylmethyl)phosphate (3-pmOpe) or diethyl (pyridin-4-ylmethyl)phosphate (4-pmOpe)] have been synthesized and tested in vitro for their cytotoxicity against mouse leukemia L1210 cells. The results indicated that the cis-platinum complexes showed superior activity than trans-palladium complexes, but lower in comparison to cisplatin. The chemical reactivity of the tested complexes has been determined in an in vitro NBP test. The platinum complexes exhibited very high chemical reactivity in NBP test, higher than cisplatin. The results showed no correlation between cytotoxicity and chemical reactivity for platinum complexes. Two platinum(II) complexes {cis-[PtCl2(2-pmOpe)2], cis-[PtCl2(3-pmOpe)2]} have been synthesized and characterized by IR, 1H NMR, 31P NMR, and elemental analysis.
Kalinowska-Lis
Urszula
U
Department of Bioinorganic Chemistry, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland. uk@ich.pharm.am.lodz.pl
Szmigiero
Leszek
L
Studzian
Kazimierz
K
Ochocki
Justyn
J
D000818:Animals; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007938:Leukemia / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D010755:Organophosphates / Q000138:chemical synthesis* / Q000494:pharmacology; D010165:Palladium; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
D009942:Organometallic Compounds; D010755:Organophosphates; C505745:diethyl (pyridin-4-ylmethyl)phosphate; D010165:Palladium; D002945:Cisplatin