title: Efficacy of chromoendoscopy with indigocarmine for the detection of ascending colon and cecum lesions.
abstract: OBJECTIVE
  Previous data suggest that routine chromoendoscopy may increase detection rates of diminutive or flat lesions. The aim of this study was to evaluate the usefulness of chromoendoscopy in the ascending colon and cecum, where the incidence of diminutive or flat lesions is high.
  
  
  METHODS
  Between June 2006 and September 2006, a total of 316 consecutive patients were prospectively enrolled in this study. The patients were randomly divided into two groups (control group: 158 patients, chromoendoscopy group: 158 patients). If the quality of bowel preparation was poor or cecal intubation was not achieved, the patient was excluded from the study. In the control group, the ascending colon and cecum were observed twice without chromoendoscopy. In the chromoendoscopy group, the cecum and ascending colon were reinspected following staining with indigocarmine solution after conventional examination of the cecum and ascending colon. Finally, a total of 151 and 149 patients were enrolled in the control and chromoendoscopy groups, respectively.
  
  
  RESULTS
  The chromoendoscopy group differed significantly from the control group in the number of additionally detected polyps (control: 14 versus chromoendoscopy: 62, p<0.001) and in the number of patients with additionally detected polyps (control: 12 versus chromoendoscopy: 50, p<0.001). Multivariate analysis revealed that detection of polyps after indigocarmine spraying was independently associated with a high body mass index and older age (p = 0.045 and p = 0.006, respectively).
  
  
  CONCLUSIONS
  With chromoendoscopy using indigocarmine, more polyps can be detected in the ascending colon and cecum as compared with using conventional colonoscopy.
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Park
authors.forename: Sang Kil
authors.initials: SK
authors.lastname: Lee
authors.forename: Byung Chang
authors.initials: BC
authors.lastname: Kim
authors.forename: Jaeyong
authors.initials: J
authors.lastname: Han
authors.forename: Jae Hak
authors.initials: JH
authors.lastname: Kim
authors.forename: Jae Hee
authors.initials: JH
authors.lastname: Cheon
authors.forename: Tae Il
authors.initials: TI
authors.lastname: Kim
authors.forename: Won Ho
authors.initials: WH
authors.lastname: Kim
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000601:surgery; D002430:Cecal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D002432:Cecum / Q000473:pathology; D044682:Colon, Ascending / Q000473:pathology; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000601:surgery; D003111:Colonic Polyps / Q000175:diagnosis / Q000601:surgery; D003113:Colonoscopy; D004396:Coloring Agents; D005260:Female; D006801:Humans; D007203:Indigo Carmine; D008297:Male; D008875:Middle Aged
chemical_list: D004396:Coloring Agents; D007203:Indigo Carmine