title: Postoperative acute disseminated encephalomyelitis after exposure to microfibrillar collagen hemostat.
abstract: Microfibrillar collagen hemostat, known by its trade name Avitene, has been used in neurosurgery for decades. Complications with this product have been documented in other surgical specialties and described as mostly immune-mediated foreign-body reactions that can lead to a granulomatous reaction. There has never been a case of disseminated encephalomyelitis associated with this topical hemostatic agent. In this report the authors present a case of postoperative acute disseminated encephalomyelitis after exposure to Avitene. Possible pathophysiological mechanisms are discussed and the pertinent literature is reviewed.
authors.affiliation: Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois 60612, USA. sepehr_sani@rush.edu
authors.forename: Sepehr
authors.initials: S
authors.lastname: Sani
authors.forename: Tibor
authors.initials: T
authors.lastname: Boco
authors.forename: Steven L
authors.initials: SL
authors.lastname: Lewis
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Cochran
authors.forename: Ajay J
authors.initials: AJ
authors.lastname: Patel
authors.forename: Richard W
authors.initials: RW
authors.lastname: Byrne
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000601:surgery; D003094:Collagen / Q000009:adverse effects*; D004673:Encephalomyelitis, Acute Disseminated / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D005910:Glioma / Q000601:surgery; D006488:Hemostasis, Surgical / Q000009:adverse effects*; D006801:Humans
chemical_list: D003094:Collagen