title: Cytotoxic activity of diterpenoids isolated from the aerial parts of Elaeoselinum asclepium subsp. meoides.
abstract: The phytochemical investigation of the acetone extract of the aerial parts of Elaeoselinum asclepium (L.) Bertol. subsp. meoides (Desf.) Fiori afforded several known diterpenoids as well as meoidic acid ( 5), new in the literature. The cytotoxic activities of elasclepic acid ( 1), ENT-atis-16-en-19-oic acid ( 2), ent-beyer-15-en-19-oic acid ( 3), ent-kaur-16-en-19-oic acid ( 4) and meoidic acid ( 5) were investigated on rat glioma C6 cells by evaluation of cell growth inhibition.
authors.affiliation: Dipartimento di Chimica Organica, Università degli Studi di Palermo, Palermo, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosselli
authors.forename: Antonella
authors.initials: A
authors.lastname: Maggio
authors.forename: Cristina
authors.initials: C
authors.lastname: Eiroa
authors.forename: Carmen
authors.initials: C
authors.lastname: Formisano
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bruno
authors.forename: Carlo
authors.initials: C
authors.lastname: Irace
authors.forename: Carmen
authors.initials: C
authors.lastname: Maffettone
authors.forename: Nicola
authors.initials: N
authors.lastname: Mascolo
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D019661:Apiaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D051381:Rats
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes