title: Effect of N-chlorotaurine mouth rinses on plaque regrowth and plaque vitality.
abstract: The purpose of this 4-day plaque regrowth study was to assess the effect of N-chlorotaurine (NCT) mouth rinses on plaque inhibition and plaque vitality. Eighty volunteers participated in this investigator-blind, randomized, clinical controlled study in parallel groups. No oral hygiene was permitted except rinsing with a 2% or 3% NCT mouth rinse, a positive or a negative control. Primary parameters were the plaque index (Silness and Löe, Acta Odontol Scand, 22:121-135, 1964) and plaque vitality (Netuschil et al., J Clin Periodontol, 16:484-488, 1989) after the final rinse. In addition, another plaque index (Turesky et al., J Periodontol, 41:41-43, 1970), plaque area, and bleeding on probing were recorded. All parameters were taken at baseline and day 5. U test was applied on a 5% error level. No differences in plaque inhibition were found between the two NCT formulations and the negative control. However, a statistically significant reduction of plaque vitality compared to the negative and positive control was observed. Discoloration of the tongue and unpleasant taste were recorded in participants in the NCT groups. NCT mouth rinses did not inhibit plaque regrowth, but they did reduce the vitality of plaque bacteria. Methods of prolonging the substantivity of the NCT mouth rinses should be investigated to enhance the antibacterial properties of these formulations.
authors.affiliation: Department of Conservative Dentistry, Medical Faculty, University of Technology Dresden, Dresden, Germany. katrin.lorenz@tu-dresden.de
authors.forename: K
authors.initials: K
authors.lastname: Lorenz
authors.forename: D
authors.initials: D
authors.lastname: Mayer
authors.forename: G
authors.initials: G
authors.lastname: Bruhn
authors.forename: B
authors.initials: B
authors.lastname: Noack
authors.forename: M
authors.initials: M
authors.lastname: Brecx
authors.forename: C
authors.initials: C
authors.lastname: Heumann
authors.forename: H
authors.initials: H
authors.lastname: Toutenburg
authors.forename: L
authors.initials: L
authors.lastname: Netuschil
authors.forename: M
authors.initials: M
authors.lastname: Nagl
authors.forename: W
authors.initials: W
authors.lastname: Gottardi
authors.forename: T
authors.initials: T
authors.lastname: Hoffmann
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D002710:Chlorhexidine / Q000627:therapeutic use; D015169:Colony Count, Microbial; D003773:Dental Plaque / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D003774:Dental Plaque Index; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005884:Gingival Hemorrhage / Q000517:prevention & control; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D010512:Periodontal Index; D010859:Pigmentation Disorders / Q000139:chemically induced; D010919:Placebos; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D016037:Single-Blind Method; D012965:Sodium Chloride; D013651:Taste Disorders / Q000139:chemically induced; D013654:Taurine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014060:Tongue Diseases / Q000139:chemically induced; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; D004791:Enzyme Inhibitors; D009067:Mouthwashes; D010919:Placebos; D013654:Taurine; D012965:Sodium Chloride; C043410:N-chlorotaurine; D019001:Nitric Oxide Synthase; D017346:Protein Serine-Threonine Kinases; D002710:Chlorhexidine