[Studies on analgesic effects and sites of oxymatrine-carbenoxolone sodium complex].
OBJECTIVE
To study the analgesic effects and sites of oxymatrine-carbenoxolone sodium complex (OCSC).


METHODS
Adopting formalin test, warm water tail-flick test and intracerebroventricularly (icv) injection to observe the analgesic effects of OCSC in mice.


RESULTS
Intraperitoneally injecting (ip) OCSC (75, 150 mg x kg(-1)) remarkedly inhibited the pain of mice in the formalin test and prolonged latent phases of tail-shrinking of mice, icy OCSC (1.875, 3.75, 7.5 mg x kg(-1)) significantly prolonged latent phases of tail-shrinking of mice, it had dose-dependent effect with concentration.


CONCLUSIONS
The result indicated that OCSC has obvious analgesic effects and its mechanism may be involved in central nervous system (CNS).
Zhou
Jun-Jun
JJ
Department of Pharmacology, Ningxia Medical College, Yinchuan 750004, China.
Jiang
Yuan-Xu
YX
Jin
Shao-Ju
SJ
Tao
Li-Jun
LJ
Liu
Li-Jun
LJ
D000470:Alkaloids / Q000737:chemistry*; D000700:Analgesics / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002229:Carbenoxolone / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010146:Pain / Q000188:drug therapy; D011807:Quinolizines / Q000737:chemistry*; D000093842:Matrines
D000470:Alkaloids; D000700:Analgesics; D002229:Carbenoxolone; D011807:Quinolizines; C037573:oxymatrine; D000093842:Matrines