title: The effects of levetiracetam on alcohol consumption in alcohol-dependent subjects: an open label study.
abstract: The aim of this open-label pilot study was to assess the efficacy and safety of the novel anticonvulsant agent, levetiracetam, for the treatment of alcohol dependence. A maximal dose of 2000 mg was administered daily for 10 weeks to alcohol dependent subjects (n = 20). Mean reported ethanol intake declined significantly from 5.3 to 1.7 standard drinks per day. Levetiracetam was well tolerated by most subjects.
authors.affiliation: Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
authors.forename: Ofra
authors.initials: O
authors.lastname: Sarid-Segal
authors.forename: Joanna
authors.initials: J
authors.lastname: Piechniczek-Buczek
authors.forename: Clifford
authors.initials: C
authors.lastname: Knapp
authors.forename: Maryam
authors.initials: M
authors.lastname: Afshar
authors.forename: Eric
authors.initials: E
authors.lastname: Devine
authors.forename: Laurie
authors.initials: L
authors.lastname: Sickles
authors.forename: Emma
authors.initials: E
authors.lastname: Uwodukunda
authors.forename: Courtney
authors.initials: C
authors.lastname: Richambault
authors.forename: Jillian
authors.initials: J
authors.lastname: Koplow
authors.forename: Domenic
authors.initials: D
authors.lastname: Ciraulo
mesh_terms: D000437:Alcoholism / Q000188:drug therapy* / Q000517:prevention & control; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D008875:Middle Aged; D010889:Piracetam / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D018091:Receptors, AMPA / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects; D018009:Receptors, Glycine / Q000187:drug effects
chemical_list: D000927:Anticonvulsants; D018091:Receptors, AMPA; D011963:Receptors, GABA-A; D018009:Receptors, Glycine; D000077287:Levetiracetam; D010889:Piracetam