Immune system in renal injury and repair: burning the candle from both ends?
This brief overview is focused on the inherent duality of immune responses: on the one hand they may induce inflammation and precipitate injury, on the other, a number of examples of participation in organ and tissue repair are growing. These processes will be reviewed from the nephrological stand-point. Specifically, the role of different leukocyte subsets, innate immunity, nitric oxide production, and stem cells, among others, are presented.
Goligorsky
Michael S
MS
Renal Research Institute and Division of Nephrology, Department of Medicine and Pharmacology, New York Medical College, Valhalla, NY 10595, United States. michael_goligorsky@nymc.edu
D000818:Animals; D042783:Endothelial Cells / Q000502:physiology; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007113:Immunity, Innate; D007668:Kidney / Q000502:physiology*; D007674:Kidney Diseases / Q000503:physiopathology*; D045164:Mesenchymal Stem Cell Transplantation; D009569:Nitric Oxide / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D051193:Toll-Like Receptors / Q000502:physiology
D051193:Toll-Like Receptors; D009569:Nitric Oxide