Ligand-free Sonogashira coupling reactions with heterogeneous Pd/C as the catalyst.
A variety of aryl iodides were coupled with aromatic and aliphatic terminal alkynes to give the corresponding 1,2-disubstituted aromatic alkynes in good yields by using only 0.4 mol % of the heterogeneous 10 % Pd/C as the catalyst without a ligand, copper salt, or amine in an aqueous medium.
Mori
Shigeki
S
Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 6-1, Mitahora-higashi 5-chome, Gifu, Japan.
Yanase
Takayoshi
T
Aoyagi
Satoka
S
Monguchi
Yasunari
Y
Maegawa
Tomohiro
T
Sajiki
Hironao
H
D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D008024:Ligands; D008968:Molecular Conformation; D010100:Oxygen / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D013696:Temperature
D008024:Ligands; D010165:Palladium; D002244:Carbon; D010100:Oxygen