title: Effect of acetazolamide on ventilatory response in subjects with chronic mountain sickness.
abstract: Although the effects of acetazolamide (ACZ) on ventilation during acute mountain sickness are well known, there are no studies assessing its effect on ventilatory response in chronic hypoxia. We studied this effect in patients with chronic mountain sickness (CMS). Subjects with CMS, living permanently at 4300 m, were assigned in a randomized, double-blind study to 250 mg/day (n=9) or to 500 mg/day (n=9) of ACZ. Resting end-tidal PET(O2) and end-tidal PET(CO2) were measured before and after 3 weeks of acetazolamide. Ventilatory responses were evaluated by the determination of sensitivity to hypoxia and to CO2. After treatment ventilatory response to hypoxia increased, resting PET(CO2) decreased, and ACZ caused a leftward shift in the position, but not a change in the slope of the ventilation (VE) versus PET(CO2) relationship. There were no differences between the two doses used. ACZ administration provides a beneficial effect on respiratory function of high altitude natives with CMS and thus it can be an effective therapy for the disease.
authors.affiliation: Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Instituto de Investigaciones de Altura, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, Lima 31, Peru. mrivera@upch.edu.pe
authors.forename: Maria
authors.initials: M
authors.lastname: Rivera-Ch
authors.forename: Luis
authors.initials: L
authors.lastname: Huicho
authors.forename: Patrick
authors.initials: P
authors.lastname: Bouchet
authors.forename: Jean Paul
authors.initials: JP
authors.lastname: Richalet
authors.forename: Fabiola
authors.initials: F
authors.lastname: León-Velarde
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use*; D000328:Adult; D000532:Altitude Sickness / Q000188:drug therapy* / Q000503:physiopathology*; D000704:Analysis of Variance; D000927:Anticonvulsants / Q000627:therapeutic use*; D002245:Carbon Dioxide / Q000494:pharmacology; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010100:Oxygen; D015656:Respiratory Mechanics / Q000187:drug effects* / Q000502:physiology
chemical_list: D000927:Anticonvulsants; D002245:Carbon Dioxide; D000086:Acetazolamide; D010100:Oxygen