Double-strand DNA cleavage from photodecarboxylation of (micro-oxo)diiron(III) L-histidine complex in visible light.
The oxo-bridged diiron(III) complex [{Fe(L-his)(dpq)}(2)(micro-O)](2+) having L-histidine (L-his) and dipyrido[3,2-d:2',3'-f]quinoxaline (dpq) bound to Fe(III) exemplifies an iron-based model photonuclease that shows visible light-induced DNA double-strand cleavage in a photodecarboxylation pathway and models iron-bleomycin activity.
Roy
Mithun
M
Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, 560012, India.
Bhowmick
Tuhin
T
Ramakumar
Suryanarayanarao
S
Nethaji
Munirathinam
M
Chakravarty
Akhil R
AR
D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D053837:DNA Cleavage / Q000528:radiation effects; D003653:Decarboxylation / Q000528:radiation effects; D005290:Ferric Compounds / Q000737:chemistry*; D006639:Histidine / Q000031:analogs & derivatives* / Q000737:chemistry*; D008027:Light; D010777:Photochemistry
D005290:Ferric Compounds; D006639:Histidine; D004247:DNA