Acute generalised exanthematous pustulosis and toxic epidermal necrolysis induced by carbamazepine.
Acute generalised exanthematous pustulosis and Stevens-Johnson syndrome (toxic epidermal necrolysis spectrum of severe cutaneous drug reactions) are believed to have distinct underlying pathophysiologies. Our patient, a 28-year-old Chinese woman, represents the first known reported case of clinically-consistent and histologically-proven acute generalised exanthematous pustulosis and toxic epidermal necrolysis overlap induced by carbamazepine in the English literature.
Goh
T K
TK
Dermatology Unit, Singapore General Hospital, Outram Road, Singapore. wuzhuqing@yahoo.com
Pang
S M
SM
Thirumoorthy
T
T
Goh
S G N
SG
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005076:Exanthema / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000473:pathology
D000927:Anticonvulsants; D002220:Carbamazepine