Effect of Picrorrhiza rhizoma extracts on early diabetic nephropathy in streptozotocin-induced diabetic rats.
The hypoglycemic effect of an aqueous extract of Picrorrhiza Rhizoma (PR) was investigated on diabetic nephropathy. The body weight of each of eight rats per group was measured 7 days after streptozotocin (STZ) treatment. The blood glucose levels 3 days after STZ treatment and the changes in body weight, kidney weight, blood glucose levels, and serum blood urea nitrogen (BUN) were also measured, and the histopathology of the kidney was examined. Body weight decreases and increases of kidney weight, blood glucose levels, and serum BUN and creatinine levels were detected in the diabetic control with histopathological changes related to diabetic nephropathy in the kidney. However, the level of hyperglycemia was significantly lowered in all groups given the PR extract. In addition, the changes related to diabetic nephropathy with the body weight were also significantly lower in the captopril and all PR extract-dosing groups than in the diabetic control. In conclusion, an aqueous extract of PR has relatively good inhibitory effects on STZ-induced diabetes with early diabetic nephropathy with a similar efficacy to an equal dose of captopril.
Lee
Hyeung-Sik
HS
Department of Herbal Biotechnology, Daegu Haany University, Gyeongsan, Republic of Korea.
Ku
Sae-Kwang
SK
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002216:Captopril / Q000008:administration & dosage; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007668:Kidney / Q000473:pathology; D009929:Organ Size; D008517:Phytotherapy; D032261:Picrorhiza / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D002216:Captopril