title: Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects.
abstract: BACKGROUND
  In the general population, low IGF1 has been associated with higher prevalence of cardiovascular disease and mortality.
  
  
  OBJECTIVE
  To investigate the relationships between IGF1 levels, blood pressure (BP), and glucose tolerance (GT).
  
  
  METHODS
  Four-hundred and four subjects (200 men aged 18-80 years).
  
  
  METHODS
  personal history of pituitary or cardiovascular diseases; previous or current treatments with drugs interfering with BP, GT, or lipids, corticosteroids (>2 weeks), estrogens, or testosterone (>12 weeks); smoking of >15 cigarettes/day and alcohol abuse (>3 glasses of wine/day).
  
  
  RESULTS
  Two hundred and ninety-six had normal BP (73.3%), 86 had mild (21.3%), and 22 had severe (5.4%) hypertension; 322 had normal GT (NGT (79.7%)), 53 had impaired glucose tolerance (IGT (13.1%)), 29 had diabetes mellitus (7.2%). Normotensive subjects had significantly higher IGF1 levels (0.11+/-0.94 SDS) than those with mild (-0.62+/-1.16 SDS, P<0.0001) or severe (-1.01+/-1.07 SDS, P<0.0001) hypertension. IGF1 SDS (t=-3.41, P=0.001) independently predicted systolic and diastolic BP (t=-2.77, P=0.006) values. NGT subjects had significantly higher IGF1 levels (0.13+/-0.90 SDS) than those with IGT (-0.86+/-1.14 SDS, P<0.0001) or diabetes mellitus (-1.31+/-1.13 SDS, P<0.0001). IGF1 SDS independently predicted fasting glucose (t=-3.49, P=0.0005) and homeostatic model assessment (HOMA)-R (t=-2.15, P=0.033) but not insulin (t=-1.92, P=0.055) and HOMA-beta (t=-0.19, P=0.85).
  
  
  CONCLUSIONS
  IGF1 levels in the low normal range are associated with hypertension and diabetes in subjects without pituitary and cardiovascular diseases.
authors.affiliation: Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S. Pansini 5, 80131 Naples, Italy. colao@unina.it
authors.forename: Annamaria
authors.initials: A
authors.lastname: Colao
authors.forename: Carolina
authors.initials: C
authors.lastname: Di Somma
authors.forename: Teresa
authors.initials: T
authors.lastname: Cascella
authors.forename: Rosario
authors.initials: R
authors.lastname: Pivonello
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vitale
authors.forename: Ludovica F S
authors.initials: LF
authors.lastname: Grasso
authors.forename: Gaetano
authors.initials: G
authors.lastname: Lombardi
authors.forename: Silvia
authors.initials: S
authors.lastname: Savastano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000378:metabolism; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology* / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology / Q000378:metabolism; D006973:Hypertension / Q000453:epidemiology* / Q000378:metabolism*; D015228:Hypertriglyceridemia / Q000453:epidemiology / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D007334:Insulin-Like Growth Factor I