title: Arylation of Phe and Tyr side chains of unprotected peptides by a Suzuki-Miyaura reaction in water.
abstract: An efficient arylation in water of tyrosine and phenylalanine side chains from unprotected iodopeptides is accomplished by using Suzuki-Miyaura cross-coupling processes. The method is compatible with the hydrophilic and thermolabile nature of biologically active peptides. Also of interest, the arylated tyrosine peptides can be accessed in one-pot mode starting from native peptides.
authors.affiliation: Instituto de Investigacions Quimicas y Ambientales de Barcelona, Jordi Girona 18-26 E08034, Barcelona, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Vilaró
authors.forename: Gemma
authors.initials: G
authors.lastname: Arsequell
authors.forename: Gregorio
authors.initials: G
authors.lastname: Valencia
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ballesteros
authors.forename: José
authors.initials: J
authors.lastname: Barluenga
mesh_terms: D004743:Enkephalin, Leucine / Q000737:chemistry; D007467:Iodoproteins / Q000737:chemistry*; D009861:Onium Compounds / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010649:Phenylalanine / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D014443:Tyrosine / Q000737:chemistry*
chemical_list: D007467:Iodoproteins; D009861:Onium Compounds; D010455:Peptides; D011725:Pyridines; C512284:bis(pyridine)iodonium(I) tetrafluoroborate; D014443:Tyrosine; D010649:Phenylalanine; D004743:Enkephalin, Leucine