Momilactone B, an allelochemical of rice hulls, induces apoptosis on human lymphoma cells (Jurkat) in a micromolar concentration.
Although momilactone B has been studied as an allelochemical of rice (Oryza sativa L.), to date we have no report showing the effect of momilactone B on mammalian cells. This study was undertaken to examine whether this allelochemical has anticancer activity on cancer cells. We show here that momilactone B at micromolar doses has antitumor efficacy by inducing apoptosis in several blood cancer cells including human leukemic T cells. In addition, our study elucidated that anticancer activity of momilactone B on human leukemic T cells resulted from the induction of apoptosis via caspase and mitochondria. From these results, momilactone B can be considered as a novel therapeutic strategy for human leukemic T cells from its direct apoptosis-inducing activity.
Lee
Seung C
SC
Dong-A University College of Medicine and Medical Science Research Center, Busan, South Korea.
Chung
Ill-Min
IM
Jin
Yeong J
YJ
Song
Yeon S
YS
Seo
Su Y
SY
Park
Bong S
BS
Cho
Kwang H
KH
Yoo
Ki S
KS
Kim
Tae-Hyun
TH
Yee
Su-Bog
SB
Bae
Yoe-Sik
YS
Yoo
Young H
YH
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000502:physiology; D002452:Cell Count; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D019169:Jurkat Cells; D007783:Lactones / Q000008:administration & dosage*; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D012275:Oryza / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*; D013601:T-Lymphocytes / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D007783:Lactones; C477203:momilactone B; D053148:Caspase 3