In vivo proton magnetic resonance spectroscopy in patients with neuroacanthocytosis.
We report the 'H-Magnetic Resonance Spectroscopy findings in two siblings with neuroacanthocytosis (NAC), along with six matched controls. Proton spectra recorded from single voxels containing putamen and globus pallidus showed a significantly higher intensity of myoinositol and choline peaks in patients when compared with controls. The myoinositol/creatine, myoinositol/N-acetyl-aspartate, and choline/creatine ratios were significantly higher in the patients than in the controls. Although the increased myoinositol signal could be a non-specific finding, it could not be excluded that it had a possible role in the pathogenesis of NAC.
Antonio Molina
J
J
Department of Neurology of Hospital Universitario 'Doce de Octubre', Madrid, Spain.
Manuel García-Segura
J
J
Benito-León
J
J
Javier Jiménez-Jiménez
F
F
Martinéz
V
V
Viaño
J
J
Bermejoa
F
F