Thermal and non-thermal methods to evaluate compatibility of granisetron hydrochloride with tablet excipients.
Compatibility of granisetron hydrochloride with selected excipients was assessed using Differential Scanning Calorimetry (DSC) as a thermal screening technique. Non-thermal methods like Fourier Transform Infrared spectroscopy and Thin Layer Chromatography were used as complementary techniques to adequately support and assist in interpretation of DSC results. Some drug-excipient interaction was observed with beta-cyclodextrin, 2-hydroxypropyl-beta-cyclodextrin, mannitol, and magnesium stearate in DSC studies. However, further evaluation of these incompatible excipients with non-thermal methods showed that these excipients were compatible with granisetron hydrochloride. Non-thermal methods were, thus, of help in interpreting DSC results and excluding all relevant pharmaceutical incompatibilities.
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Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA 30341, USA.
Banga
A K
AK
D000932:Antiemetics / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D002855:Chromatography, Thin Layer; D005079:Excipients; D005947:Glucose; D017829:Granisetron / Q000737:chemistry*; D065347:Hypromellose Derivatives; D008353:Mannitol; D008747:Methylcellulose / Q000031:analogs & derivatives; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets; D013696:Temperature; D047392:beta-Cyclodextrins
D000932:Antiemetics; D005079:Excipients; D005947:Glucose; D017829:Granisetron; D065347:Hypromellose Derivatives; D008353:Mannitol; D008747:Methylcellulose; D013607:Tablets; D047392:beta-Cyclodextrins