Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension.
To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.
Pravenec
Michal
M
Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, 14220 Prague, Czech Republic.
Churchill
Paul C
PC
Churchill
Monique C
MC
Viklicky
Ondrej
O
Kazdova
Ludmila
L
Aitman
Timothy J
TJ
Petretto
Enrico
E
Hubner
Norbert
N
Wallace
Caroline A
CA
Zimdahl
Heike
H
Zidek
Vaclav
V
Landa
Vladimir
V
Dunbar
Joseph
J
Bidani
Anil
A
Griffin
Karen
K
Qi
Nathan
N
Maxova
Martina
M
Kren
Vladimir
V
Mlejnek
Petr
P
Wang
Jiaming
J
Kurtz
Theodore W
TW
D000818:Animals; D018955:CD36 Antigens / Q000235:genetics*; D006973:Hypertension / Q000235:genetics*; D007668:Kidney / Q000378:metabolism; D040641:Quantitative Trait Loci; D051381:Rats; D011918:Rats, Inbred SHR
D018955:CD36 Antigens