title: Significance of D2-40 expression in the diagnosis of gastrointestinal stromal tumor.
abstract: We incidentally found the expression of D2-40 in Cajal interstitial cells for the immunohistochemical valuation of lymphatic invasion by gastric and colonic cancer cells. Therefore, we suggested that D2-40 might become an available marker for gastrointestinal stromal tumors (GISTs). In this study, we performed immunohistochemical study of 21 GISTs, As a result, we confirmed a positive reaction for D2-40 in sixteen GISTs. Among sixteen tumors, thirteen tumors were focally positive and remaining three tumors were diffusely positive. We could find no relationship between positive findings for D2-40 and size or location of the tumor. Three of four tumors with intermediate risk of aggressive behavior and two of four tumors with recurrence showed a negative reaction for D2-40. In conclusion, we suggest that D2-40 may be an available marker of GISTs, but the expression of D2-40 seems to be not associated with the degree of risk of aggressive behavior.
authors.affiliation: Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2-13-51 Shin-honmachi, Kochi, Japan. kurochankochi@yahoo.co.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Kuroda
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Tanida
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Oonishi
authors.forename: Kaori
authors.initials: K
authors.lastname: Inoue
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ohara
authors.forename: Keiko
authors.initials: K
authors.lastname: Mizuno
authors.forename: Takahiro
authors.initials: T
authors.lastname: Taguchi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hanazaki
authors.forename: Gang-Hong
authors.initials: GH
authors.lastname: Lee
mesh_terms: D000911:Antibodies, Monoclonal / Q000378:metabolism*; D000954:Antigens, Surface / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D041981:Gastrointestinal Tract / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D021381:Protein Transport
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D014408:Biomarkers, Tumor