title: Assessment of anatomic relation between pulmonary perfusion and morphology in pulmonary emphysema with breath-hold SPECT-CT fusion images.
abstract: OBJECTIVE
  Anatomic relation between pulmonary perfusion and morphology in pulmonary emphysema was assessed on deep-inspiratory breath-hold (DIBrH) perfusion single-photon emission computed tomography (SPECT)-CT fusion images.
  
  
  METHODS
  Subjects were 38 patients with pulmonary emphysema and 11 non-smoker controls, who successfully underwent DIBrH and non-BrH perfusion SPECT using a dual-headed SPECT system during the period between January 2004 and June 2006. DIBrH SPECT was three-dimensionally co-registered with DIBrH CT to comprehend the relationship between lung perfusion defects and CT low attenuation areas (LAA). By comparing the appearance of lung perfusion on DIBrH with non-BrH SPECT, the correlation with the rate constant for the alveolar-capillary transfer of carbon monoxide (DLCO/VA) was compared between perfusion abnormalities on these SPECTs and LAA on CT.
  
  
  RESULTS
  DIBrH SPECT provided fairly uniform perfusion in controls, but significantly enhanced perfusion heterogeneity when compared with non-BrH SPECT in pulmonary emphysema patients (P < 0.001). The reliable DIBrH SPECT-CT fusion images confirmed more extended perfusion defects than LAA on CT in majority (73%) of patients. Perfusion abnormalities on DIBrH SPECT were more closely correlated with DLCO/VA than LAA on CT (P < 0.05).
  
  
  CONCLUSIONS
  DIBrH SPECT identifies affected lungs with perfusion abnormality better than does non-BrH SPECT in pulmonary emphysema. DIBrH SPECT-CT fusion images are useful for more accurately localizing affected lungs than morphologic CT alone in this disease.
authors.affiliation: Department of Radiology, St. Hill Hospital, 1462-3 Nishikiwa, Ube 755-0151, Japan. sugar@sthill-hp.or.jp
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Suga
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Iwanaga
authors.forename: Noriko
authors.initials: N
authors.lastname: Hayashi
authors.forename: Akiko
authors.initials: A
authors.lastname: Seto
authors.forename: Naofumi
authors.initials: N
authors.lastname: Matsunaga
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation; D011656:Pulmonary Emphysema / Q000175:diagnosis*; D015203:Reproducibility of Results; D015656:Respiratory Mechanics; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013382:Subtraction Technique; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*