title: Patients after atrial switch operation for transposition of the great arteries can not increase stroke volume under dobutamine stress as opposed to patients with congenitally corrected transposition.
abstract: BACKGROUND
  Patients after atrial switch operation for transposition of the great arteries have limited exercise performance. Rigid atrial baffles may cause a relative preload reduction. Previous studies have had suboptimal control groups, which ideally should consist of patients with congenitally corrected transposition of the great arteries (ccTGA) without previous heart surgery, having a systemic right ventricle, but lacking rigid atrial baffles. Therefore the aim of this study was to test the impact of atrial baffles by comparing 12 atrial switch patients with 11 ccTGA patients.
  
  
  RESULTS
  Systemic right ventricular stroke volume (SV), heart rate, cardiac index, and other parameters were assessed during rest and dobutamine stress magnetic resonance imaging. The most important difference between the groups was that the atrial switch patients could not increase SV during stress, whereas ccTGA patients increased it significantly. There was no difference between groups in the rise of the cardiac index. Heart rate increased significantly more in atrial switch patients than in ccTGA patients.
  
  
  CONCLUSIONS
  The results support the hypothesis that atrial baffles restrict a rise in SV under dobutamine stress in patients after atrial switch operation for transposition of the great arteries.
authors.affiliation: Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Klinik an der Technischen Universität München, Lazarettstrasse 36, 80636 Munich, Germany. fratz@dhm.mhn.de
authors.forename: Sohrab
authors.initials: S
authors.lastname: Fratz
authors.forename: Alfred
authors.initials: A
authors.lastname: Hager
authors.forename: Raymonde
authors.initials: R
authors.lastname: Busch
authors.forename: Harald
authors.initials: H
authors.lastname: Kaemmerer
authors.forename: Markus
authors.initials: M
authors.lastname: Schwaiger
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Lange
authors.forename: John
authors.initials: J
authors.lastname: Hess
authors.forename: Heiko C
authors.initials: HC
authors.lastname: Stern
mesh_terms: D000293:Adolescent; D000328:Adult; D002316:Cardiotonic Agents; D002648:Child; D004280:Dobutamine; D005080:Exercise Test; D005260:Female; D006325:Heart Atria / Q000473:pathology / Q000601:surgery; D006339:Heart Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000473:pathology*; D013318:Stroke Volume / Q000187:drug effects; D014188:Transposition of Great Vessels / Q000473:pathology / Q000601:surgery*; D016278:Ventricular Function, Right
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine