title: Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis.
abstract: Reactive oxygen species (ROS) are implicated in the pathogenesis of multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). The effect of edaravone, a free radical scavenger, on EAE was investigated in this study. Treatment with edaravone significantly ameliorated the clinical severity of EAE, and a reduced infiltration of lymphocytes was observed based on a histological analysis. The expression of inducible NO synthase (iNOS) in the spinal cords appeared to be reduced by the treatment with edaravone and this effect was confirmed in vitro. A reduction of both the cellular infiltration and the expression of iNOS may therefore underlie the mechanisms of the beneficial effect of edaravone on EAE.
authors.affiliation: Department of Neurology (D-4), Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Moriya
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nakatsuji
authors.forename: Katsuichi
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Tatsusada
authors.initials: T
authors.lastname: Okuno
authors.forename: Makoto
authors.initials: M
authors.lastname: Kinoshita
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kumanogoh
authors.forename: Susumu
authors.initials: S
authors.lastname: Kusunoki
authors.forename: Saburo
authors.initials: S
authors.lastname: Sakoda
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017252:CD3 Complex / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002461:Cell Line, Transformed; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects; D000077553:Edaravone; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D051379:Mice; D008840:Microfilament Proteins; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D013116:Spinal Cord / Q000187:drug effects / Q000201:enzymology; D018709:Statistics, Nonparametric
chemical_list: C491049:Aif1 protein, mouse; D017252:CD3 Complex; D002135:Calcium-Binding Proteins; D016166:Free Radical Scavengers; D008840:Microfilament Proteins; D052247:Nitric Oxide Synthase Type II; D000077553:Edaravone; D000983:Antipyrine