Pentraxins, humoral innate immunity and tissue injury.
Tissue damage elicits an inflammatory response, which comprises the rapid synthesis of acute phase molecules. The early local response shapes the resolution of inflammation. Pentraxins are evolutionary conserved soluble pattern recognition receptors, produced in the liver (e.g. C-reactive protein) or at sites of inflammation (the long pentraxin PTX3). Pentraxins behave as flexible adaptors of innate cell functions, complement activation and clearance of cell and matrix debris, regulating tissue hyperplasia and scarring and limiting the risk of autoimmunity associated to unscheduled cell death in vivo.
Manfredi
Angelo A
AA
H. San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, via Olgettina 58, Milan 20132, Italy.
Rovere-Querini
Patrizia
P
Bottazzi
Barbara
B
Garlanda
Cecilia
C
Mantovani
Alberto
A
D000209:Acute-Phase Proteins / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D017209:Apoptosis / Q000276:immunology*; D002097:C-Reactive Protein / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D000683:Serum Amyloid P-Component / Q000276:immunology / Q000378:metabolism*; D014947:Wounds and Injuries / Q000276:immunology / Q000378:metabolism; D000099153:Pentraxins
D000209:Acute-Phase Proteins; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins