Treatment of parasitic diarrhea in HIV-infected patients.
Parasitic infections responsible for diarrhea have a worldwide distribution, overlapping with AIDS in most countries. Indeed, highly active antiretroviral therapy has markedly reduced the incidence of most parasitic opportunistic infections, but parasite-related diarrhea remains frequent and probably underestimated in developing countries. In this review, we focus on the advances in molecular epidemiology, diagnosis and current treatment of the most prevalent parasitic infections in HIV-infected patients. Most of these parasites are protozoa, whose diagnosis at the laboratory requires some adapted technique and expertise. We highlight the importance of diagnosis and the skill of the laboratory of parasitology, since most parasitic infections responsible for diarrhea in AIDS patients can be treated.
Derouin
Francis
F
Laboratory of Parasitology and Mycology, University Paris 7 and Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, 1 Avenue Claude Vellefaux, 75475 Paris Cedex 10, France. francis.derouin@sls.aphp.fr
Lagrange-Xelot
Marie
M
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D003967:Diarrhea / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D056890:Eukaryota / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D017720:Molecular Epidemiology; D011528:Protozoan Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology
D000981:Antiprotozoal Agents