Ecto-5'-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis.
In previous studies, we have demonstrated that adenosine and its receptors play a role in hepatic fibrosis. Here, we review evidence that toxin-induced increases in hepatic adenosine concentrations are generated from adenine nucleotides by the action of ecto-5'nucleotidase and thus that adenosine-mediated, toxin-induced hepatic fibrosis depends on extracellular conversion of adenine nucleotides to adenosine.
Peng
Zhongsheng
Z
Department of Medicine, Division of Clinical Pharmacology, New York University School of Medicine, New York, New York 10016, USA.
Fernandez
Patricia
P
Wilder
Tuere
T
Yee
Herman
H
Chiriboga
Luis
L
Chan
Edwin S L
ES
Cronstein
Bruce N
BN
D015720:5'-Nucleotidase / Q000235:genetics / Q000378:metabolism*; D000241:Adenosine / Q000096:biosynthesis*; D000818:Animals; D005110:Extracellular Space / Q000378:metabolism*; D005355:Fibrosis / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000473:pathology*
D015720:5'-Nucleotidase; D000241:Adenosine