Rod a-wave analysis using high intensity flashes adds information on rod system function in 25% of clinical ERG recordings.
OBJECTIVE
To investigate whether rod a-wave analysis using high intensity flashes adds information above that obtained with standard ERG.


METHODS
A total of 2,396 eyes were recorded. Patient age was 2.4 months-84.6 years.


RESULTS
A-wave analysis of high intensity flashes provided additional information on rod system function in 25% of eyes recorded, most importantly in subjects with midretinal disease and artificially reduced rod responses. High intensity flashes also provided measurable responses for longitudinal monitoring in rod dystrophies with non-recordable rod ERGs.


CONCLUSIONS
Clinical ERG testing would benefit greatly from adding high intensity flashes to its standard testing conditions.
Nilsson
Josefin
J
Department of Clinical Neurophysiology, Sahlgrenska Academy, University of Gothenburg, Blå stråket 7-3 tr, 413 45 Göteborg, Sweden. josefin.nilsson@neuro.gu.se
Wright
Tom
T
Westall
Carol A
CA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D004596:Electroretinography / Q000379:methods; D006801:Humans; D007223:Infant; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D017948:Retinal Rod Photoreceptor Cells / Q000502:physiology*; D012174:Retinitis Pigmentosa / Q000175:diagnosis / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted