Autoantibodies to the high-affinity IgE receptor in patients with asthma.
Autoimmune diseases have been implicated as a cause of intrinsic asthma; however, there is little data on the role of autoimmunity in the pathogenesis of asthma. The purpose of this study was to investigate circulating autoantibodies against the high-affinity IgE receptor Fc(epsilon)RI in patients with asthma. Seventy-eight patients with asthma and 32 healthy individuals as control subjects were included. All subjects were tested with basophil histamine releasing assay and immunoblotting to assess for the potential presence of receptor Fc(epsilon)RI autoantibodies. Of the 78 asthma patients total subjects, 25 (32.1%) had a positive by basophil histamine releasing assay and 23 (29.5%) by immunoblotting. Both of them were significant higher than the positive rate, 9.4% (p < 0.05) and 9.4% (p < 0.05), respectively. Our data demonstrated that aberrant autoantibodies against the high-affinity IgE receptor Fc(epsilon)RI were found in some patients with asthma implies that the autoimmunity may be one factor in intrinsic asthma pathogenesis.
Sun
Ren-Shan
RS
Department of Dermatology, Institute of Battle Surgery, Daping Hospital, the Third Military Medical University, Chongqing 400042, People's Republic of China..
Chen
Xiao-Hong
XH
Liu
Rong-Qing
RQ
Cheng
Tian-Min
TM
Ran
Xin-Ze
XZ
Yang
Tao
T
D001249:Asthma / Q000276:immunology* / Q000378:metabolism; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology*; D015551:Autoimmunity; D001491:Basophils / Q000276:immunology* / Q000378:metabolism; D006636:Histamine Release; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D017455:Receptors, IgE / Q000276:immunology*
D001323:Autoantibodies; D007074:Immunoglobulin G; D017455:Receptors, IgE