Relation of heart rate with cardiovascular disease in normal-weight individuals: the Chicago Heart Association Detection Project in Industry.
The authors investigated the association of resting heart rate (RHR) with cardiovascular disease (CVD) risk factors and mortality among normal-weight individuals. Using data from our cohort (baseline examination in 1967-1973), individuals with a body mass index of 18.5 to 24.9 kg/m(2) (men [n=3724] and women [n=4929] aged 18-39; men [n=1959] and women [n=3735] aged 40-59), were grouped by RHR: <75, 75-84, and > or =85 beats per minute (bpm). A lower RHR was associated with lower mean blood pressure (BP) and cigarette use in each subgroup and total cholesterol (TC) and diabetes in men (P<.05). After a 32-year follow-up, hazard ratios (95% confidence intervals) for CVD mortality for an RHR <75 compared with > or =85 bpm adjusted for age, race, education level, BP, cigarette use, diabetes, and TC were 0.58 (0.34-0.84), 0.73(0.56-0.95), and 0.77 (0.61-0.98) for men aged 18 to 39 and men and women aged 40 to 59, respectively. In women aged 18 to 39, the relationship was not significant. In general, normal-weight individuals with lower RHRs have lower levels of CVD risk factors and mortality.
Kizilbash
Mohammad Ali
MA
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 Lake Shore Drive, Chicago, IL 60611, USA.
Daviglus
Martha L
ML
Dyer
Alan R
AR
Garside
Dan B
DB
Hankinson
Arlene L
AL
Yan
Lijing L
LL
Tian
Lu
L
Van
Linda
L
Wang
Renwei
R
Greenland
Philip
P
D000328:Adult; D001835:Body Weight / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology; D002641:Chicago / Q000453:epidemiology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012955:Societies, Medical; D015996:Survival Rate / Q000639:trends