title: No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients.
abstract: OBJECTIVE
  This study investigated whether the brain-derived neurotrophic factor (BDNF) gene Val66Met single-nucleotide polymorphism (SNP) is associated with antipsychotic-induced tardive dyskinesia (TD) in schizophrenia.
  
  
  METHODS
  Genotyping was performed for the BDNF gene Val66Met SNP in Korean schizophrenic patients with (n=83) and without TD (n=126) who were matched for antipsychotic drug exposure and other relevant variables.
  
  
  RESULTS
  The frequencies of genotypes (chi2=2.37, p=0.306) and alleles (chi2=0.03, p=0.867) did not differ significantly between these two groups.
  
  
  CONCLUSIONS
  These findings suggest that the BDNF polymorphism does not play a major role in the susceptibility to TD in schizophrenic patients.
authors.affiliation: Department of Psychiatry, Korea University College of Medicine, and Kangbuk Samsung Hospital, Seoul, South Korea.
authors.forename: Seung-Gul
authors.initials: SG
authors.lastname: Kang
authors.forename: Jung-Eun
authors.initials: JE
authors.lastname: Choi
authors.forename: Hyonggin
authors.initials: H
authors.lastname: An
authors.forename: Se-Won
authors.initials: SW
authors.lastname: Lim
authors.forename: Heon-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Changsu
authors.initials: C
authors.lastname: Han
authors.forename: Yong-Ku
authors.initials: YK
authors.lastname: Kim
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Sung Nam
authors.initials: SN
authors.lastname: Cho
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Lee
authors.forename: Sook-Haeng
authors.initials: SH
authors.lastname: Joe
authors.forename: In-Kwa
authors.initials: IK
authors.lastname: Jung
authors.forename: Leen
authors.initials: L
authors.lastname: Kim
mesh_terms: D000328:Adult; D000483:Alleles; D019943:Amino Acid Substitution; D014150:Antipsychotic Agents / Q000009:adverse effects; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D004409:Dyskinesia, Drug-Induced / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000502:physiology; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy / Q000235:genetics*
chemical_list: D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor