Distinctive homing profile of pathogen-specific activated lymphocytes in human urinary tract infection.
In contrast to other mucosal sites, information on migration/homing of lymphocytes activated in the human urinary tract is lacking. The expression of lymphocyte homing receptors (HR) on pathogen-specific antibody-secreting cells (ASC) originating from the urinary tract (patients with pyelonephritis, PN) was compared to that on antigen-specific ASC originating from the intestine (patients with gastroenteritis) or from a parenteral site (tetanus toxoid-immunized volunteers). In the PN group, 61% of ASC expressed the gut HR, alpha(4)beta(7,) 52% the peripheral lymph node HR, L-selectin, and 13% the skin HR, CLA. This homing profile of urinary tract-originating lymphocytes was found to differ from both of the two major vaccination routes, intestinal (less gut-targeting) or parenteral (more gut-targeting, less targeting to parenteral sites). This information on targeting of the immune response may prove useful when developing vaccines against urinary tract infection (UTI).
Kantele
Anu M
AM
Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, Helsinki, Finland. anu.kantele@hus.fi
Palkola
Nina V
NV
Arvilommi
Heikki S
HS
Kantele
Jussi M
JM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000921:Antibody-Producing Cells / Q000276:immunology* / Q000378:metabolism; D002465:Cell Movement; D005260:Female; D005759:Gastroenteritis / Q000276:immunology; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000276:immunology / Q000378:metabolism; D019041:L-Selectin / Q000276:immunology / Q000378:metabolism; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D011704:Pyelonephritis / Q000276:immunology*; D016201:Receptors, Lymphocyte Homing / Q000276:immunology / Q000378:metabolism*; D013745:Tetanus Toxoid / Q000276:immunology; D014552:Urinary Tract Infections / Q000276:immunology* / Q000378:metabolism
D016023:Integrins; D016201:Receptors, Lymphocyte Homing; D013745:Tetanus Toxoid; D019041:L-Selectin