title: Generation and characterization of diesel exhaust in a facility for controlled human exposures.
abstract: An idling medium-duty diesel truck operated on ultralow sulfur diesel fuel was used as an emission source to generate diesel exhaust for controlled human exposure. Repeat tests were conducted on the Federal Test Procedure using a chassis dynamometer to demonstrate the reproducibility of this vehicle as a source of diesel emissions. Exhaust was supplied to a specially constructed exposure chamber at a target concentration of 100 microg x m(-3) diesel particulate matter (DPM). Spatial variability within the chamber was negligible, whereas emission concentrations were stable, reproducible, and similar to concentrations observed on the dynamometer. Measurements of nitric oxide, nitrogen dioxide, carbon monoxide, particulate matter (PM), elemental and organic carbon, carbonyls, trace elements, and polycyclic aromatic hydrocarbons were made during exposures of both healthy and asthmatic volunteers to DPM and control conditions. The effect of the so-called "personal cloud" on total PM mass concentrations was also observed and accounted for. Conventional lung function tests in 11 volunteer subjects (7 stable asthmatic) did not demonstrate a significant change after 2-hr exposures to diesel exhaust. In summary, we demonstrated that this facility can be effectively and safely used to evaluate acute responses to diesel exhaust exposure in human volunteers.
authors.affiliation: Department of Chemical and Environmental Engineering and Center for Environmental Research and Technology, Bourns College of Engineering, University of California, Riverside, CA 92521, USA.
authors.forename: Aniket A
authors.initials: AA
authors.lastname: Sawant
authors.forename: David R
authors.initials: DR
authors.lastname: Cocker
authors.forename: J Wayne
authors.initials: JW
authors.lastname: Miller
authors.forename: Tony
authors.initials: T
authors.lastname: Taliaferro
authors.forename: David
authors.initials: D
authors.lastname: Diaz-Sanchez
authors.forename: William S
authors.initials: WS
authors.lastname: Linn
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Clark
authors.forename: Henry
authors.initials: H
authors.lastname: Gong
mesh_terms: D000388:Air / Q000032:analysis; D000395:Air Pollutants, Occupational / Q000009:adverse effects / Q000032:analysis; D001273:Atmosphere Exposure Chambers; D004305:Dose-Response Relationship, Drug; D005742:Gasoline; D006801:Humans; D052638:Particulate Matter / Q000032:analysis; D014131:Trace Elements / Q000032:analysis; D001335:Vehicle Emissions / Q000032:analysis*
chemical_list: D000395:Air Pollutants, Occupational; D005742:Gasoline; D052638:Particulate Matter; D014131:Trace Elements; D001335:Vehicle Emissions