Arterial stiffness in children after renal transplantation.
Long-term survival after successful transplantation is limited by cardiovascular disease. We studied changes in arterial function in children after renal transplantation. We measured pulse-wave velocity (PWV) and the augmentation index (AIX) as estimated from central pulse-wave analysis in 36 patients with a functioning kidney transplant (mean age 14 +/- 3.4 years) and 49 healthy children (mean age 13.3 +/- 3.3 years). Transplantation had been performed 4.3 +/- 3.3 years prior to examination. Transplanted patients had a significantly higher mean PWV of 5.43 +/- 0.9 m/s; controls 4.68 +/- 0.7 m/s. Likewise, the AIX was significantly higher in patients (-14.3 +/- 15.2) than in controls -26.3 +/- 13.5. We found no significant associations with the degree of transplant dysfunction, glomerular filtration rate (GFR) loss, or dose of immunosuppressive medications; however, the AIX was associated with the serum calcium-phosphorus product, and PWV correlated with systolic blood pressure and age. This study suggests that subclinical arteriopathy is present in young transplant recipients.
Briese
Sonia
S
Department of Pediatric Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Claus
Maren
M
Querfeld
Uwe
U
D000293:Adolescent; D000367:Age Factors; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002118:Calcium / Q000097:blood; D002339:Carotid Arteries / Q000502:physiology*; D016022:Case-Control Studies; D002648:Child; D004548:Elasticity / Q000502:physiology*; D005260:Female; D005263:Femoral Artery / Q000502:physiology*; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D010758:Phosphorus / Q000097:blood; D012039:Regional Blood Flow / Q000502:physiology; D055815:Young Adult
D010758:Phosphorus; D002118:Calcium