title: In vivo proton magnetic resonance spectroscopy in patients with neuroacanthocytosis.
abstract: We report the 'H-Magnetic Resonance Spectroscopy findings in two siblings with neuroacanthocytosis (NAC), along with six matched controls. Proton spectra recorded from single voxels containing putamen and globus pallidus showed a significantly higher intensity of myoinositol and choline peaks in patients when compared with controls. The myoinositol/creatine, myoinositol/N-acetyl-aspartate, and choline/creatine ratios were significantly higher in the patients than in the controls. Although the increased myoinositol signal could be a non-specific finding, it could not be excluded that it had a possible role in the pathogenesis of NAC.
authors.affiliation: Department of Neurology of Hospital Universitario 'Doce de Octubre', Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Antonio Molina
authors.forename: J
authors.initials: J
authors.lastname: Manuel García-Segura
authors.forename: J
authors.initials: J
authors.lastname: Benito-León
authors.forename: F
authors.initials: F
authors.lastname: Javier Jiménez-Jiménez
authors.forename: V
authors.initials: V
authors.lastname: Martinéz
authors.forename: J
authors.initials: J
authors.lastname: Viaño
authors.forename: F
authors.initials: F
authors.lastname: Bermejoa