Memory impairment induced by low doses of reserpine in rats: possible relationship with emotional processing deficits in Parkinson disease.
We have recently verified that the monoamine-depleting drug reserpine--at doses that do not modify motor function--impairs memory in a rodent model of aversive discrimination. In this study, the effects of reserpine (0.1-0.5 mg/kg) on the performance of rats in object recognition, spatial working memory (spontaneous alternation) and emotional memory (contextual freezing conditioning) tasks were investigated. While object recognition and spontaneous alternation behavior were not affected by reserpine treatment, contextual fear conditioning was impaired. Together with previous studies, these results suggest that low doses of reserpine would preferentially induce deficits in tasks involved with emotional contexts. Possible relationships with cognitive and emotional processing deficits in Parkinson disease are discussed.
Fernandes
Valéria S
VS
Memory Studies Laboratory, Physiology Department, Federal University of Rio Grande do Norte, Natal, Brazil.
Ribeiro
Alessandra M
AM
Melo
Thieza G
TG
Godinho
Monique
M
Barbosa
Flavio F
FF
Medeiros
Danielle S
DS
Munguba
Hermany
H
Silva
Regina H
RH
D000818:Animals; D014150:Antipsychotic Agents / Q000633:toxicity*; D003627:Data Interpretation, Statistical; D004644:Emotions / Q000187:drug effects*; D005239:Fear / Q000187:drug effects / Q000523:psychology; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced* / Q000523:psychology*; D008570:Memory, Short-Term / Q000187:drug effects; D010300:Parkinson Disease / Q000523:psychology*; D051381:Rats; D017208:Rats, Wistar; D021641:Recognition, Psychology / Q000187:drug effects; D012110:Reserpine / Q000633:toxicity*; D012938:Social Perception; D013028:Space Perception / Q000187:drug effects
D014150:Antipsychotic Agents; D012110:Reserpine