title: Synthesis of 3'-deoxy-3'-C-methyl nucleoside derivatives.
abstract: 2',3'-Dideoxy-3'-C-methyl nucleosides bearing the five naturally occurring nucleic acid bases were synthesized. Additionally, the 3'-deoxy-3'-C-methyl nucleoside analogues bearing 5-aminoimidazole-4-carboxamide as well as 1,2,4-triazole-3-carboxamide moieties were prepared. The synthesis of the corresponding 2',3'-dideoxy-3'-C-methyl triazole derivative was also accomplished. The dideoxynucleoside derivatives were prepared by radical deoxygenation from their 3'-deoxy-3'-C-methyl parent ribonucleosides. When evaluated for their antiviral activity in cell culture experiments, none of these compounds showed any significant antiviral activity.
authors.affiliation: Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM 1-UM 2, Université Montpellier 2, Case Courrier 1705, Place E. Bataillon, 34095 Montpellier cedex 05, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Aljarah
authors.forename: Sarah
authors.initials: S
authors.lastname: Couturier
authors.forename: Christophe
authors.initials: C
authors.lastname: Mathé
authors.forename: Christian
authors.initials: C
authors.lastname: Périgaud
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides