title: Dietary patterns and risk of bladder cancer: a factor analysis in Uruguay.
abstract: OBJECTIVE
  To determine the major dietary patterns associated with bladder cancer risk, we conducted a principal components analysis (PCA) in a case-control study from Uruguay.
  
  
  METHODS
  A total of 255 newly diagnosed and microscopically confirmed cases of transitional cell carcinoma of the bladder and 501 hospitalized controls were included in the study. Both series were drawn from the four major public hospitals in Montevideo, Uruguay. Cases and controls were frequency matched on age and sex. Controls were submitted to factor (principal components) analysis.
  
  
  RESULTS
  We retained three factors that explained 25.1% of the total variance (including error variance). The first factor was labeled as the sweet beverages pattern. This factor was characterized by high loadings of coffee, tea, and added sugar and was strongly associated with risk of bladder cancer (OR 3.27, 95% CI 1.96-5.45). The second factor was labeled as the Western pattern and displayed high loadings of red meat, fried eggs, potatoes, and red wine. This pattern was directly associated with risk of bladder cancer (OR 2.35, 95% CI 1.42-3.89). Finally, the third factor was labeled as the prudent pattern and showed high loadings of fresh vegetables, cooked vegetables, and fruits. This pattern was not associated with risk of bladder cancer.
  
  
  CONCLUSIONS
  According to our study, non-alcoholic beverages were the strongest risk factor for bladder cancer, whereas the Western pattern was also associated with a significant increase in risk of bladder cancer.
authors.affiliation: Departamento de Anatomía Patológica, Facultad de Medicina, Hospital de Clínicas, Montevideo, Uruguay. estefani@adinet.com.uy
authors.forename: Eduardo
authors.initials: E
authors.lastname: De Stefani
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Alvaro L
authors.initials: AL
authors.lastname: Ronco
authors.forename: Hugo
authors.initials: H
authors.lastname: Deneo-Pellegrini
authors.forename: Giselle
authors.initials: G
authors.lastname: Acosta
authors.forename: María
authors.initials: M
authors.lastname: Mendilaharsu
mesh_terms: D017677:Age Distribution; D001628:Beverages; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D016022:Case-Control Studies; D003069:Coffee; D016001:Confidence Intervals; D004032:Diet / Q000706:statistics & numerical data*; D004493:Education; D005163:Factor Analysis, Statistical; D005192:Family Health; D005260:Female; D006801:Humans; D030019:Ilex paraguariensis; D007407:Interviews as Topic; D008297:Male; D016017:Odds Ratio; D025341:Principal Component Analysis; D012307:Risk Factors; D012424:Rural Population / Q000706:statistics & numerical data; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D013662:Tea; D014505:Urban Population / Q000706:statistics & numerical data; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D014583:Uruguay / Q000453:epidemiology
chemical_list: D003069:Coffee; D013662:Tea