title: Effects of brain-derived neurotrophic factor-catecholamine-O-methyltransferase gene interaction on schizophrenic symptoms.
abstract: The methionine variant of Val66Met brain-derived neurotrophic factor BDNF met and catecholamine-O-methyltransferase (COMT L) is associated with a deficit in attention and aggravation of delusions in schizophrenia. We hypothesized that the BDNF-COMT gene interaction would affect the symptoms and cognition in schizophrenia. Ninety-six schizophrenic patients and 79 control participants were recruited. The patients who were BDNF met/met x COMT L carriers had the highest scores of delusion of Positive Symptoms and the Scale for Assessment of Negative Symptoms, word reading of the color word test, and trail-making test B time, compared with the other three genotype interactions. The current results suggest that patients with the BDNF met/met x COMT L allele had more delusional symptoms and poorer cognitive flexibility, compared with the other three genotype interactions.
authors.affiliation: Department of Psychiatry College of Medicine, Daegu Catholic University, Daegu, Seoul, South Korea.
authors.forename: Doug Hyun
authors.initials: DH
authors.lastname: Han
authors.forename: Doo Byung
authors.initials: DB
authors.lastname: Park
authors.forename: Tae Young
authors.initials: TY
authors.lastname: Choi
authors.forename: So Youn
authors.initials: SY
authors.lastname: Joo
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Bo Rae G
authors.initials: BR
authors.lastname: Park
authors.forename: Ryoji
authors.initials: R
authors.lastname: Nishimura
authors.forename: Chung-Chou
authors.initials: CC
authors.lastname: Chu
authors.forename: Perry F
authors.initials: PF
authors.lastname: Renshaw
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology; D003702:Delusions / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000523:psychology; D005820:Genetic Testing / Q000706:statistics & numerical data; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D014936:Word Association Tests / Q000706:statistics & numerical data
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D002394:Catechol O-Methyltransferase