A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands.
A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands is reported.
Liu
Kevin G
KG
Chemical & Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, USA. liuk1@wyeth.com
Lo
Jennifer R
JR
Comery
Thomas A
TA
Zhang
Guo Ming
GM
Zhang
Jean Y
JY
Kowal
Dianne M
DM
Smith
Deborah L
DL
Di
Li
L
Kerns
Edward H
EH
Schechter
Lee E
LE
Robichaud
Albert J
AJ
D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D007700:Kinetics; D008024:Ligands; D008956:Models, Chemical; D015394:Molecular Structure; D011485:Protein Binding / Q000187:drug effects; D011985:Receptors, Serotonin / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014363:Tryptamines / Q000737:chemistry
D007211:Indoles; D008024:Ligands; D011985:Receptors, Serotonin; D014363:Tryptamines; C097216:serotonin 6 receptor