title: Pharmacokinetics of buprenorphine following intravenous and oral transmucosal administration in dogs.
abstract: Pharmacokinetic analysis of buprenorphine administered to six healthy dogs via the oral transmucosal (OTM) route at doses of 20 and 120 microg/kg was conducted using liquid chromatography-electrospray ionization-tandem mass spectroscopy (LC-ESI-MS/MS). Bioavailability was 38% plus or minus 12% for the 20 microg/kg dose and 47%+/-16% for the 120 microg/kg dose. Maximum plasma concentrations were similar for buprenorphine doses of 20 microg/kg IV and 120 microg/kg OTM. Sedation and salivation were common side effects, but no bradycardia, apnea, or cardiorespiratory depressive effects were seen. When the two OTM dosing rates were normalized to dose, LC-ESI-MS/MS analysis of buprenorphine and its metabolites detected no significant difference (P>.05), indicating dose proportionality. The results of this study suggest that OTM buprenorphine may be an alternative for pain management in dogs.
authors.affiliation: Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Abbo
authors.forename: Jeff C H
authors.initials: JC
authors.lastname: Ko
authors.forename: Lara K
authors.initials: LK
authors.lastname: Maxwell
authors.forename: Raymond E
authors.initials: RE
authors.lastname: Galinsky
authors.forename: David E
authors.initials: DE
authors.lastname: Moody
authors.forename: Brenda M
authors.initials: BM
authors.lastname: Johnson
authors.forename: Wenfang B
authors.initials: WB
authors.lastname: Fang
mesh_terms: D000284:Administration, Oral; D000701:Analgesics, Opioid / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002047:Buprenorphine / Q000097:blood / Q000493:pharmacokinetics*; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D018592:Cross-Over Studies; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy*; D004285:Dogs / Q000097:blood / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous / Q000662:veterinary; D007408:Intestinal Absorption / Q000187:drug effects; D013058:Mass Spectrometry; D010146:Pain / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine