title: Low-level laser therapy improves vision in patients with age-related macular degeneration.
abstract: OBJECTIVE
  The objective of this study of a case series was to examine the effects of low-level laser therapy (LLLT) in patients with age-related macular degeneration (AMD).
  
  
  BACKGROUND
  AMD affects a large proportion of the elderly population; current therapeutic options for AMD are limited, however.
  
  
  METHODS
  In total, 203 patients (90 men and 113 women; mean age 63.4 +/- 5.3 y) with beginning ("dry") or advanced ("wet") forms of AMD (n = 348 eyes) were included in the study. One hundred ninety-three patients (mean age 64.6 +/- 4.3 y; n = 328 eyes) with cataracts (n = 182 eyes) or without cataracts (n = 146 eyes) were treated using LLLT four times (twice per week). A semiconductor laser diode (780 nm, 7.5 mW, 292 Hz, continuous emission) was used for transconjunctival irradiation of the macula for 40 sec (0.3 J/cm2) resulting in a total dose of 1.2 J/cm2. Ten patients (n = 20 eyes) with AMD received mock treatment and served as controls. Visual acuity was measured at each visit. Data were analyzed retrospectively using a t-test.
  
  
  RESULTS
  LLLT significantly improved visual acuity (p < 0.00001 versus baseline) in 162/182 (95%) of eyes with cataracts and 142/146 (97%) of eyes without cataracts. The prevalence of metamorphopsia, scotoma, and dyschromatopsia was reduced. In patients with wet AMD, edema and bleeding improved. The improved vision was maintained for 3-36 mo after treatment. Visual acuity in the control group remained unchanged. No adverse effects were observed in those undergoing therapy.
  
  
  CONCLUSIONS
  In patients with AMD, LLLT significantly improved visual acuity without adverse side effects and may thus help to prevent loss of vision.
authors.affiliation: University of Heidelberg, Otto-Meyerhof Centre, Heidelberg. boris.ivandic@med.uni-heidelberg.de
authors.forename: Boris T
authors.initials: BT
authors.lastname: Ivandic
authors.forename: Tomislav
authors.initials: T
authors.lastname: Ivandic
mesh_terms: D005260:Female; D006801:Humans; D028022:Low-Level Light Therapy; D008268:Macular Degeneration / Q000503:physiopathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D014792:Visual Acuity / Q000502:physiology*