title: [Obstructive sleep apnea contribution to oxidative stress in obesity].
abstract: OBJECTIVE
  The aim of this paper was to check the influence of obstructive sleep apnea (OSA) on obesity oxidative stress and CPAP (Continuous Positive Airway Pressure) effect on oxidative stress and in these patients.
  
  
  METHODS
  Twenty nine male patients considered obese (BMI > 30 kg/m(2)) were divided into 3 groups: a) Group I: 10 OSA free patients (apnea-hipopnea index (AHI) < 5); b) Group 2: 10 with moderate to serious OSA (AHI > 20); c) Group 3: 9 with OSA from moderate to serious (AHI > 20) using CPAP, minimum 4 hours/night for 2 months.
  
  
  RESULTS
  Significant differences before and after CPAP usage were observed in group 3 in the following variables: reduction of superoxide (SO) production [13.2 (10.3-19.6) vs. 10.5 (5.8-11.8) nmoles O2(-)/2 x 10(6) PMN] and increase in serum nitrite/nitrates levels [24.5 (16.7-33.5) vs. 49.5 (39.3-58.1) microM]. Positive correlation between Apnea-Hypopnea Index (AHI) and SO (r = 0,726) and negative correlation was observed between AHI and serum nitrite/nitrates levels (r = - 0.867).
  
  
  CONCLUSIONS
  In conclusion, oxidative stress present in obesity is elevated by OSA and CPAP treatment can rise the levels of SO and can decrease serum nitrite/nitrates present in obese patients with OSA.
authors.affiliation: Universidade de São Paulo, São Paulo, Brasil. annamyrna@uol.com.br
authors.forename: Anna Myrna Jaguaribe de
authors.initials: AM
authors.lastname: Lima
authors.forename: Clélia M Ribeiro
authors.initials: CM
authors.lastname: Franco
authors.forename: Célia M M Barbosa de
authors.initials: CM
authors.lastname: Castro
authors.forename: Alice de Andrade
authors.initials: Ade A
authors.lastname: Bezerra
authors.forename: Luiz
authors.initials: L
authors.lastname: Ataíde
authors.forename: Alfredo
authors.initials: A
authors.lastname: Halpern
mesh_terms: D015992:Body Mass Index; D045422:Continuous Positive Airway Pressure; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology*; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D013481:Superoxides / Q000097:blood
chemical_list: D009566:Nitrates; D009573:Nitrites; D013481:Superoxides