title: [Preparation and evaluation in vivo of Scutellaria thermosensitive gel].
abstract: OBJECTIVE
  To study scutellaria thermosensitive gel in situ.
  
  
  METHODS
  The phase transition temperature of gel with various concentration polymer solutions was studied by using stirring method and the viscosity of gel was monitored under different temperatures. Eye irritation experiments were performed with rabbit. The duration of residence time in rabbit eyes of scutellaria thermosensitive gel was observed with 2% fluorescein.
  
  
  RESULTS
  20% poloxmar407 and 10% poloxmar 188 were suitable to scutellaria thermosen-sitive gel in situ. The results suggested that the scutellaria thermosensitive gel in situ based on poloxmar were nonirritant and retention time on the surface of eye was (150 +/- 8) min.
  
  
  CONCLUSIONS
  The scutellaria thermosensitive gel in situ forms gel in eye and has longer release time than that of eye drops.
authors.affiliation: Bright Way Pharmaceutical Technology limited company, Harbin 150025, China. dragonsongchj@163.com
authors.forename: Cheng-Jun
authors.initials: CJ
authors.lastname: Song
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Tian
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Liu
authors.forename: Rui-Bin
authors.initials: RB
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D005123:Eye / Q000187:drug effects; D005260:Female; D005782:Gels; D008297:Male; D009883:Ophthalmic Solutions / Q000378:metabolism; D020442:Poloxamer / Q000737:chemistry; D011817:Rabbits; D031363:Scutellaria / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D012680:Sensitivity and Specificity; D013997:Time Factors; D044366:Transition Temperature
chemical_list: D004365:Drugs, Chinese Herbal; D005782:Gels; D009883:Ophthalmic Solutions; D020442:Poloxamer