title: Ecto-5'-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis.
abstract: In previous studies, we have demonstrated that adenosine and its receptors play a role in hepatic fibrosis. Here, we review evidence that toxin-induced increases in hepatic adenosine concentrations are generated from adenine nucleotides by the action of ecto-5'nucleotidase and thus that adenosine-mediated, toxin-induced hepatic fibrosis depends on extracellular conversion of adenine nucleotides to adenosine.
authors.affiliation: Department of Medicine, Division of Clinical Pharmacology, New York University School of Medicine, New York, New York 10016, USA.
authors.forename: Zhongsheng
authors.initials: Z
authors.lastname: Peng
authors.forename: Patricia
authors.initials: P
authors.lastname: Fernandez
authors.forename: Tuere
authors.initials: T
authors.lastname: Wilder
authors.forename: Herman
authors.initials: H
authors.lastname: Yee
authors.forename: Luis
authors.initials: L
authors.lastname: Chiriboga
authors.forename: Edwin S L
authors.initials: ES
authors.lastname: Chan
authors.forename: Bruce N
authors.initials: BN
authors.lastname: Cronstein
mesh_terms: D015720:5'-Nucleotidase / Q000235:genetics / Q000378:metabolism*; D000241:Adenosine / Q000096:biosynthesis*; D000818:Animals; D005110:Extracellular Space / Q000378:metabolism*; D005355:Fibrosis / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000473:pathology*
chemical_list: D015720:5'-Nucleotidase; D000241:Adenosine