[AGE receptor: a novel pro-inflammatory pathway for chronic respiratory disorders?].
Interstitial pneumonites represent a heterogeneous group of respiratory disorders with known causes or idiopathic, in which alveolar injury is followed by defense and repair mechanisms either with pro- and anti-inflammatory properties. It is hypothetised that common factors would orchestrate such events, and RAGE is one of possible such candidates. Implications connected to RAGE pathway in varying interstitial pneumonites are discussed.
Campo
Ilaria
I
Clinica Malattie Apparato Respiratorio, Laboratorio di Biochimica e Genetica, Fondazione IRCCS Policlinico San Matteo, Università di Pavia, Pavia.
Morbini
Patrizia
P
Pozzi
Ernesto
E
Luisetti
Maurizio
M
D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D029481:Bronchitis, Chronic / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D017563:Lung Diseases, Interstitial / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D011658:Pulmonary Fibrosis / Q000378:metabolism; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism*; D012120:Respiration Disorders / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D017565:Sarcoidosis, Pulmonary / Q000378:metabolism
D015415:Biomarkers; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic