Base behavior behind budding breasts: integrins and mammary stem cell activity.
In a recent Nature Cell Biology paper, Taddei et al. (2008) reveal that deletion of beta1 integrin from K5-expressing mammary epithelial basal cells specifically attenuates ductal stem cell activity, without dramatically altering the basal cell layer, or morphogenesis overall.
Alexander
Caroline M
CM
McArdle Lab for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison WI 53706, USA. alexander@oncology.wisc.edu
D000818:Animals; D002454:Cell Differentiation; D005260:Female; D019012:Integrin beta1 / Q000502:physiology; D016023:Integrins / Q000502:physiology*; D053569:Keratin-15; D053555:Keratin-5 / Q000502:physiology; D007774:Lactation; D008321:Mammary Glands, Animal / Q000166:cytology* / Q000254:growth & development / Q000502:physiology*; D051379:Mice; D008892:Milk / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*
D019012:Integrin beta1; D016023:Integrins; D053569:Keratin-15; D053555:Keratin-5; C492053:Krt15 protein, mouse