Breaking down EMT.
Epithelial-mesenchymal transition, in which epithelial cells lose their polarity and become motile mesenchymal cells, occurs during development and marks a key step in tumour progression towards metastasis. Most studies of this process have focused on the disassembly of adherens junctions, but regulation of basement membrane breakdown by a pathway involving RhoA and microtubules may be equally important.
Levayer
Romain
R
IBDML, UMR6216 CNRS-Université de la Méditerranée, Campus de Luminy, 13288 Marseille Cedex 09, France.
Lecuit
Thomas
T
D022005:Adherens Junctions / Q000378:metabolism*; D000818:Animals; D001485:Basement Membrane / Q000378:metabolism*; D016764:Cell Polarity; D018450:Disease Progression; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology*; D004848:Epithelium / Q000502:physiology*; D008648:Mesoderm / Q000166:cytology / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D015398:Signal Transduction / Q000502:physiology; D020742:rhoA GTP-Binding Protein / Q000235:genetics / Q000378:metabolism
D020742:rhoA GTP-Binding Protein