title: Cardenolides from Antiaris toxicaria as potent selective Nur77 modulators.
abstract: Toxicarioside D (1), a new cardenolide, along with 10 other known ones, was isolated from the stem of Antiaris toxicaria LESCH. by bioassay-guided fractionation. Their structures were determined on the basis of spectroscopic analysis. All the reported compounds effectively inhibited the growth of various cancer cell lines at nanomolar concentrations. Inhibition of cancer cell growth was accompanied with induction of the expression of Nur77, a potent apoptotic member of the steroid/thyroid hormone receptor superfamily.
authors.affiliation: College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Miao-Miao
authors.initials: MM
authors.lastname: Jiang
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Xue
authors.initials: X
authors.lastname: Zhang
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Wang
authors.forename: Jia-You
authors.initials: JY
authors.lastname: He
authors.forename: Qiong-Ying
authors.initials: QY
authors.lastname: Hu
authors.forename: Jin-Zhang
authors.initials: JZ
authors.lastname: Zeng
authors.forename: Xiao-Kun
authors.initials: XK
authors.lastname: Zhang
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002298:Cardenolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D012333:RNA, Messenger / Q000032:analysis; D011987:Receptors, Steroid / Q000235:genetics*; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides; D004268:DNA-Binding Proteins; C539821:NR4A1 protein, human; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D012333:RNA, Messenger; D011987:Receptors, Steroid