Two cases of trisomy 19 as a sole chromosomal abnormality in myeloid disorders.
Trisomy 19 is frequently encountered in cases of chronic myeloid leukemia (CML) as a secondary abnormality: however, trisomy 19 rarely occurs as a sole chromosomal abnormality and, to date, it has only been reported in 48 hematopoietic malignancies, 1 case of adenocarcinoma and 1 case of astrocytic tumor. Here, we report two additional cases of trisomy 19 as a sole karyotypic aberration in myeloid malignancies. One of these cases involved a 6-month-old male who was diagnosed with acute myeloid leukemia minimally differentiated. His karyotype was 47,XY,+19[20]. He expired 5 days after diagnosis. Another case occurred in an 80-yr-old female who had refractory anemia with excess blasts. Her karyotype was 47,XX,+19[16]/46,XX[4]. Four months later, her peripheral blood smears suggested that the disease had progressed, but she refused further evaluation. Based on a review of the existing literature and the results of this report, trisomy 19 not only as a secondary abnormality but also as a sole karyotypic aberration is strongly associated with myeloid disorder; however, it is not preferentially found in specific FAB subgroups of myelodysplasic syndrome or acute myeloid leukemia.
Jung
Soon Il
SI
Department of Laboratory Medicine, Yeungnam University College of Medicine, Daegu, Korea.
Cho
Hee Soon
HS
Lee
Chae Hoon
CH
Kim
Kyong Dong
KD
Ha
Jung Ok
JO
Kim
Min-Kyoung
MK
Lee
Kyung Hee
KH
Hyun
Myung Soo
MS
D000208:Acute Disease; D000369:Aged, 80 and over; D000753:Anemia, Refractory / Q000175:diagnosis* / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D014314:Trisomy