title: Relation between neutralization of Epstein-Barr virus and antibodies to cell-membrane antigens-induced by the virus.
abstract: The neutralization of Epstein-Barr virus (EBV) infectivity by sera with known antibody activities against EBV-associated antigens was investigated in experimentally infected Raji and RPMI 64-10 cells. Antibodies against EBV-induced cell-membrane antigens were apparently responsible for neutralization of viral infectivity. Antibodies against EBV capsid antigens and EBV-induced early antigens were not involved. The implication of these results on the relationship of the membrane antigens to the infectious virus particle is discussed.
authors.affiliation: Laboratories at The Children's Hospital of Philadelphia, Pennsylvania, USA.
authors.forename: G
authors.initials: G
authors.lastname: Pearson
authors.forename: F
authors.initials: F
authors.lastname: Dewey
authors.forename: G
authors.initials: G
authors.lastname: Klein
authors.forename: G
authors.initials: G
authors.lastname: Henle
authors.forename: W
authors.initials: W
authors.lastname: Henle
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D002051:Burkitt Lymphoma / Q000276:immunology / Q000821:virology; D002213:Capsid / Q000276:immunology; D002277:Carcinoma / Q000276:immunology / Q000821:virology; D003601:Cytotoxicity Tests, Immunologic; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007106:Immune Sera; D007244:Infectious Mononucleosis / Q000276:immunology; D007951:Leukemia, Myeloid / Q000276:immunology / Q000821:virology; D009303:Nasopharyngeal Neoplasms / Q000276:immunology / Q000821:virology; D009369:Neoplasms / Q000276:immunology* / Q000821:virology*; D009500:Neutralization Tests; D014763:Viral Matrix Proteins / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; C037662:EBV-associated membrane antigen, Epstein-Barr virus; C033305:Epstein-Barr virus early antigen; D007106:Immune Sera; D014763:Viral Matrix Proteins