Team effort by TRAPP forces a nucleotide fumble.
TRAPPI is a multisubunit protein complex on the Golgi that activates the small GTPase Ypt1p to facilitate the receipt of transport vesicles inbound from the endoplasmic reticulum. Cai et al. (2008) now present structural and biochemical analyses of yeast TRAPPI in a complex with Ypt1p revealing a unique mechanism by which TRAPPI catalyzes guanine nucleotide exchange.
Nottingham
Ryan M
RM
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307, USA.
Pfeffer
Suzanne R
SR
D006056:Golgi Apparatus; D020662:Guanine Nucleotide Exchange Factors / Q000737:chemistry / Q000378:metabolism; D006150:Guanine Nucleotides / Q000378:metabolism*; D021381:Protein Transport; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism*; D020691:rab GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*
D020662:Guanine Nucleotide Exchange Factors; D006150:Guanine Nucleotides; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins; C406327:transport protein particle, TRAPP; C060755:YPT1 protein, S cerevisiae; D020691:rab GTP-Binding Proteins