title: Propindilactones E-J, Schiartane Nortriterpenoids from Schisandra propinqua var. propinqua.
abstract: Six new nortriterpenoids, propindilatones E-J (1-6), and two known (7, 8) schiartane-type nortriterpenoids were isolated from the stems of Schisandra propinqua var. propinqua. Their structures were elucidated by extensive spectroscopic analyses, and the structure of compound 4 was confirmed through single-crystal X-ray diffraction. The absolute configuration of compounds 1-3 was established using CD methods. Compounds 4-6 were noncytotoxic against K562, A549, and HT-29 human cancer cells.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Chun
authors.initials: C
authors.lastname: Lei
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Ji-Jun
authors.initials: JJ
authors.lastname: Chen
authors.forename: Li-Bin
authors.initials: LB
authors.lastname: Yang
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Yin
authors.initials: Y
authors.lastname: Chang
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Hao
authors.initials: H
authors.lastname: Huang
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C512130:schiartane