title: Evaluation of an AIF correction algorithm for dynamic susceptibility contrast-enhanced perfusion MRI.
abstract: For longitudinal studies in patients suffering from cerebrovascular diseases the poor reproducibility of perfusion measurements via dynamic susceptibility-weighted contrast-enhanced MRI (DSC-MRI) is a relevant concern. We evaluate a novel algorithm capable of overcoming limitations in DSC-MRI caused by partial volume and saturation issues in the arterial input function (AIF) by a blood flow stimulation-study. In 21 subjects, perfusion parameters before and after administration of blood flow stimulating L-arginine were calculated utilizing a block-circulant singular value decomposition (cSVD). A total of two different raters and three different rater conditions were employed to select AIFs: Besides 1) an AIF selection by an experienced rater, a beginner rater applied a steady state-oriented strategy, returning; 2) raw; and 3) corrected AIFs. Highly significant changes in regional cerebral blood flow (rCBF) by 9.0% (P < 0.01) could only be found when the AIF correction was performed. To further test for improved reproducibility, in a subgroup of seven subjects the baseline measurement was repeated 6 weeks after the first examination. In this group as well, using the correction algorithm decreased the SD of the difference between the two baseline measurements by 42%.
authors.affiliation: Berlin NeuroImaging Center (BNIC), Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany. peter.brunecker@charite.de
authors.forename: Peter
authors.initials: P
authors.lastname: Brunecker
authors.forename: Matthias
authors.initials: M
authors.lastname: Endres
authors.forename: Christian H
authors.initials: CH
authors.lastname: Nolte
authors.forename: Jörg
authors.initials: J
authors.lastname: Schultze
authors.forename: Susanne
authors.initials: S
authors.lastname: Wegener
authors.forename: Gerhard Jan
authors.initials: GJ
authors.lastname: Jungehülsing
authors.forename: Bianca
authors.initials: B
authors.lastname: Müller
authors.forename: Christian M
authors.initials: CM
authors.lastname: Kerskens
authors.forename: Jochen B
authors.initials: JB
authors.lastname: Fiebach
authors.forename: Arno
authors.initials: A
authors.lastname: Villringer
authors.forename: Jens
authors.initials: J
authors.lastname: Steinbrink
mesh_terms: D000465:Algorithms; D001120:Arginine / Q000494:pharmacology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010477:Perfusion; D015203:Reproducibility of Results
chemical_list: D001120:Arginine