title: Temporal cortex dopamine D2/3 receptor binding in major depression.
abstract: The aim of this study was to assess the dopamine function of the temporal cortex in major depressive disorder using [(123)I]epidepride to image D(2/3) receptor binding sites. Ten major depressives and 10 healthy controls were selected from a general population sample for single-photon emission computed tomography imaging. Among the major depressives there was a strong bilateral correlation between the scores on the 21-item Hamilton Depression Rating Scale and D(2/3) receptor binding. Dopaminergic abnormalities may be present in the temporal cortices of major depressives.
authors.affiliation: Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland. soili.lehto@kuh.fi
authors.forename: Soili M
authors.initials: SM
authors.lastname: Lehto
authors.forename: Jyrki
authors.initials: J
authors.lastname: Kuikka
authors.forename: Tommi
authors.initials: T
authors.lastname: Tolmunen
authors.forename: Jukka
authors.initials: J
authors.lastname: Hintikka
authors.forename: Heimo
authors.initials: H
authors.lastname: Viinamäki
authors.forename: Ritva
authors.initials: R
authors.lastname: Vanninen
authors.forename: Kaisa
authors.initials: K
authors.lastname: Haatainen
authors.forename: Heli
authors.initials: H
authors.lastname: Koivumaa-Honkanen
authors.forename: Kirsi
authors.initials: K
authors.lastname: Honkalampi
authors.forename: Jari
authors.initials: J
authors.lastname: Tiihonen
mesh_terms: D000328:Adult; D001549:Benzamides; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000523:psychology; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2 / Q000502:physiology*; D050637:Receptors, Dopamine D3 / Q000502:physiology*; D013223:Statistics as Topic; D013702:Temporal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D001549:Benzamides; D007457:Iodine Radioisotopes; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; C063525:epidepride