Antiulcerogenic activity of bark extract of Tabebuia avellanedae, Lorentz ex Griseb.
Tabebuia avellanedae is commonly used for the treatment of peptic ulcers. We carried out this study with the ethanolic extract of bark from Tabebuia avellanedae (EET) (30-1000 mg/kg) to determine its gastroprotective activity and to clarify the pathways involved in this effect. Acute gastric ulceration in rats was produced by oral administration of ethanol and ibuprofen. After ethanol administration, the gastric wall mucus was examined. Chronic gastric ulceration was produced by injection of acetic acid in rat gastric subserosa. Anti-secretory studies were undertaken using Shay rat pylorus ligature technique and measurement of enzymatic activity of H+, K+-ATPase in vitro. Administration of EET p.o. or i.p. significantly inhibited gastric mucosa damage induced by ethanol and ibuprofen. The anti-ulcer effect was further confirmed by enhanced gastric mucus production. In pylorus ligature rats, EET significantly reduced the basal gastric acid secretion and total acidity; moreover, it inhibited the increase in total acidity induced by histamine. In addition, EET reduced the activity of H+, K+, ATPase. The results obtained in the present pharmacological assay indicate that this plant has a protective action against gastric lesions, involving the maintenance of protective factors, such as mucus and prostaglandin, besides the reduction of gastric total acidity.
Twardowschy
André
A
Department of Pharmacology, Universidade Federal do Paraná, PR, Brazil.
Freitas
Cristina Setim
CS
Baggio
Cristiane Hatsuko
CH
Mayer
Bárbara
B
dos Santos
Ana Cristina
AC
Pizzolatti
Moacir Geraldo
MG
Zacarias
Aline Alvarez
AA
dos Santos
Elide Pereira
EP
Otuki
Michel Fleith
MF
Marques
Maria Consuelo Andrade
MC
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism; D007052:Ibuprofen / Q000633:toxicity; D051379:Mice; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy; D029663:Tabebuia
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D017506:H(+)-K(+)-Exchanging ATPase; D007052:Ibuprofen