title: Cranberry juice constituents impair lymphoma growth and augment the generation of antilymphoma antibodies in syngeneic mice.
abstract: In addition to its nutritional value, cranberry juice has been effective in treating urinary tract infections. Various reports have also demonstrated its potential for inhibiting in vitro growth of transformed cell lines. Here we show that a fraction [nondialyzable material (NDM) of a molecular weight range 12,000-30,000 (NDM 12-30K)] derived from cranberry juice impairs in vitro growth and invasion through extracellular matrix of Rev-2-T-6 murine lymphoma cells. Furthermore, intraperitoneal injection of this fraction at nontoxic doses both inhibits the growth of Rev-2-T-6 tumors in vivo and enhances the generation of antilymphoma antibodies. These findings demonstrate the in vivo efficacy of cranberry components against malignant lymphoma in immune competent hosts.
authors.affiliation: Department of Prosthodontics, Faculty of Dental Medicine, Hebrew University-Hadassah, Jerusalem, Israel. hochman@vms.huji.ac.il
authors.forename: Nira
authors.initials: N
authors.lastname: Hochman
authors.forename: Yael
authors.initials: Y
authors.lastname: Houri-Haddad
authors.forename: Jennifer
authors.initials: J
authors.lastname: Koblinski
authors.forename: Larry
authors.initials: L
authors.lastname: Wahl
authors.forename: Maayan
authors.initials: M
authors.lastname: Roniger
authors.forename: Allan
authors.initials: A
authors.lastname: Bar-Sinai
authors.forename: Ervin I
authors.initials: EI
authors.lastname: Weiss
authors.forename: Jacob
authors.initials: J
authors.lastname: Hochman
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis; D000951:Antigens, Neoplasm / Q000276:immunology; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D001628:Beverages / Q000032:analysis*; D015153:Blotting, Western; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D005638:Fruit / Q000737:chemistry*; D007114:Immunization; D007163:Immunosorbent Techniques; D008223:Lymphoma / Q000276:immunology* / Q000473:pathology*; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D029799:Vaccinium macrocarpon / Q000737:chemistry*
chemical_list: D000906:Antibodies; D000951:Antigens, Neoplasm; D000972:Antineoplastic Agents, Phytogenic