title: Audit of the management of antiretroviral treatment-naïve HIV patients in Greater Manchester, UK.
abstract: We evaluated the management of antiretroviral treatment (ART)-naïve HIV-positive patients in Greater Manchester against the 2005 British HIV association (BHIVA) guidelines. Fifty-seven HIV patients (median age 36 years, 61% males, 53% black Africans) commenced their first ART regimen between 1 October and 31 December 2005. Most of them presented with advanced HIV disease (74% had CD4 lymphocytes <200 and 33% were Centers for Disease Control and Prevention stage C) and 51% commenced ART within three months of their HIV diagnosis. Ninety-six percent had baseline laboratory investigations performed but only 53% had baseline blood pressure estimation. Only 25% had urinalysis performed. A combination of two nucleoside reverse transcriptase inhibitors (NRTI) and one non-NRTI was chosen in 76% of patients. Eighty-two percent of patients had a clinical review and blood tests within five weeks of starting treatment.
authors.affiliation: Monsall Unit, Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, The Pennine Acute Hospitals NHS Trust, UK.
authors.forename: Libuse
authors.initials: L
authors.lastname: Ratcliffe
authors.forename: Orla
authors.initials: O
authors.lastname: McQuillan
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Higgins
authors.forename: Edmund G L
authors.initials: EG
authors.lastname: Wilkins
authors.forename: F J
authors.initials: FJ
authors.lastname: Vilar
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008297:Male; D008330:Management Audit; D012189:Retrospective Studies; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D017320:HIV Protease Inhibitors