title: Effect of sildenafil on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction.
abstract: OBJECTIVE
  To analyze the effects of sildenafil citrate on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction.
  
  
  METHODS
  In this randomized, double-blind, placebo-controlled trial 22 women received a 50-mg dose of sildenafil (n=11) or placebo (n=11) daily for 15 days. The Golombok Rust Inventory of Sexual Satisfaction (GRISS) was used for subjective evaluation of the sexual-response cycle. Clitoral blood flow was measured by color and pulse Doppler at baseline, after 1 hour of taking the first dose, and after 15 days of treatment.
  
  
  RESULTS
  Blood flow was significantly more improved in the sildenafil than in the placebo group (P<0.05), and a positive correlation between Doppler values and GRISS scores was noted in the sildenafil group after only 15 days of treatment.
  
  
  CONCLUSIONS
  Sildenafil may improve clitoral blood flow and increase the GRISS scores in postmenopausal women with orgasmic dysfunction.
authors.affiliation: Department of Obstetrics and Gynecology, University of São Paulo, Brazil.
authors.forename: Ana L
authors.initials: AL
authors.lastname: Cavalcanti
authors.forename: Vicente R
authors.initials: VR
authors.lastname: Bagnoli
authors.forename: Angela M
authors.initials: AM
authors.lastname: Fonseca
authors.forename: Roberto A
authors.initials: RA
authors.lastname: Pastore
authors.forename: Eduardo B
authors.initials: EB
authors.lastname: Cardoso
authors.forename: Jucilene S
authors.initials: JS
authors.lastname: Paixão
authors.forename: José M
authors.initials: JM
authors.lastname: Soares
authors.forename: Fabrício
authors.initials: F
authors.lastname: Saad
authors.forename: Edmund C
authors.initials: EC
authors.lastname: Baracat
mesh_terms: D001783:Blood Flow Velocity; D002987:Clitoris / Q000098:blood supply / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D010549:Personal Satisfaction; D010879:Piperazines / Q000494:pharmacology*; D017698:Postmenopause; D011687:Purines / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D012735:Sexual Dysfunction, Physiological / Q000503:physiopathology*; D020018:Sexual Dysfunctions, Psychological / Q000503:physiopathology*; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000494:pharmacology*; D018615:Ultrasonography, Doppler, Color; D018617:Ultrasonography, Doppler, Pulsed; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate