title: Linking calcium-channel isoforms to potential therapies.
abstract: Voltage-gated calcium channels underlie a plethora of physiological functions in the cardiovascular and nervous systems. Calcium channels are considered important targets for the treatment of conditions such as absence epilepsy and hypertension, and significant efforts are increasing to discover novel calcium-channel modulators for the treatment of pain. An overview of advances in the development of calcium-channel therapeutics in the areas of pain, epilepsy and disorders associated with cardiovascular function are discussed.
authors.affiliation: Neuromed Pharmaceuticals, Vancouver, Canada.
authors.forename: Francesco
authors.initials: F
authors.lastname: Belardetti
authors.forename: Gerald W
authors.initials: GW
authors.lastname: Zamponi
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D015220:Calcium Channels / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D020747:Calcium Channels, T-Type / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010146:Pain / Q000188:drug therapy
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D020747:Calcium Channels, T-Type; D002317:Cardiovascular Agents