title: Multidrug-resistant Acinetobacter baumannii pneumonia in lung transplant recipients.
abstract: We present 6 cases of multidrug-resistant (MDR) Acinetobacter baumannii pneumonia in lung transplant recipients. All cases were treated with imipenem and/or non-traditional antibiotics, such as tigecycline and colistimethate, and had different microbiologic and clinical outcomes. Prior treatment with broad-spectrum anti-microbial therapy was the single most likely risk factor for the development of infection due to MDR Acinetobacter baumannii. Ideal preventive and therapeutic strategies for this pathogen in lung transplant recipients require further study.
authors.affiliation: Department of Internal Medicine, Division of Infectious Diseases, The Ohio State University Medical Center, Columbus, OH 43210, USA. madhuri.sopirala@osumc.edu
authors.forename: Madhuri M
authors.initials: MM
authors.lastname: Sopirala
authors.forename: Amy
authors.initials: A
authors.lastname: Pope-Harman
authors.forename: David R
authors.initials: DR
authors.lastname: Nunley
authors.forename: Susan
authors.initials: S
authors.lastname: Moffatt-Bruce
authors.forename: Patrick
authors.initials: P
authors.lastname: Ross
authors.forename: Stanley I
authors.initials: SI
authors.lastname: Martin
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy* / Q000382:microbiology*; D040981:Acinetobacter baumannii; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D003091:Colistin / Q000031:analogs & derivatives / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008911:Minocycline / Q000031:analogs & derivatives / Q000627:therapeutic use; D011014:Pneumonia / Q000188:drug therapy* / Q000382:microbiology*; D012307:Risk Factors; D000078304:Tigecycline; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D000078304:Tigecycline; D015378:Imipenem; C004691:colistinmethanesulfonic acid; D008911:Minocycline; D003091:Colistin