title: Ring-closing metathesis in the synthesis of BC ring-systems of taxol.
abstract: BC ring-systems of taxol with different or no protecting group for the C1,C2-diol moiety have been efficiently synthesized. The eight-membered B ring is formed by a ring-closing metathesis reaction (RCM) between the C10 and C11 carbon atoms. The influence of the 1,2-diol protecting group on the RCM reaction has been studied in detail.
authors.affiliation: Laboratoire de Synthèse Organique, CNRS UMR 7652, Ecole Polytechnique, DCSO, Palaiseau Cedex, France.
authors.forename: Cong
authors.initials: C
authors.lastname: Ma
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Schiltz
authors.forename: Xavier F
authors.initials: XF
authors.lastname: Le Goff
authors.forename: Joëlle
authors.initials: J
authors.lastname: Prunet
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D017239:Paclitaxel / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel