Pharmacokinetics of buprenorphine following intravenous and oral transmucosal administration in dogs.
Pharmacokinetic analysis of buprenorphine administered to six healthy dogs via the oral transmucosal (OTM) route at doses of 20 and 120 microg/kg was conducted using liquid chromatography-electrospray ionization-tandem mass spectroscopy (LC-ESI-MS/MS). Bioavailability was 38% plus or minus 12% for the 20 microg/kg dose and 47%+/-16% for the 120 microg/kg dose. Maximum plasma concentrations were similar for buprenorphine doses of 20 microg/kg IV and 120 microg/kg OTM. Sedation and salivation were common side effects, but no bradycardia, apnea, or cardiorespiratory depressive effects were seen. When the two OTM dosing rates were normalized to dose, LC-ESI-MS/MS analysis of buprenorphine and its metabolites detected no significant difference (P>.05), indicating dose proportionality. The results of this study suggest that OTM buprenorphine may be an alternative for pain management in dogs.
Abbo
Lisa A
LA
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Ko
Jeff C H
JC
Maxwell
Lara K
LK
Galinsky
Raymond E
RE
Moody
David E
DE
Johnson
Brenda M
BM
Fang
Wenfang B
WB
D000284:Administration, Oral; D000701:Analgesics, Opioid / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002047:Buprenorphine / Q000097:blood / Q000493:pharmacokinetics*; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D018592:Cross-Over Studies; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy*; D004285:Dogs / Q000097:blood / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous / Q000662:veterinary; D007408:Intestinal Absorption / Q000187:drug effects; D013058:Mass Spectrometry; D010146:Pain / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome
D000701:Analgesics, Opioid; D002047:Buprenorphine