title: Sedentariness and increased visceral adiposity in adult perinatally iron-deficient rats.
abstract: BACKGROUND
  Perinatal iron deficiency (PID) adversely programs offspring resulting in alterations in adult cardiometabolic function. Increased visceral adiposity is the proposed culprit for these sequelae, and may be potentiated by decreased physical activity. Herein, we determined (i) the effect of PID on visceral adipose tissue (VAT) and locomotor activity, and (ii) whether increased VAT is associated with blood pressure responsiveness to increased dietary sodium.
  
  
  RESULTS
  Dams were fed a low iron diet (<10 mg/kg Fe) prior to and throughout gestation. From 12 to 35 weeks of age, locomotor activity (assessed by radiotelemetry) in PID offspring was 25% lower compared with control offspring (P<0.001). At 36 weeks of age, PID offspring had 15% more VAT than controls (P<0.05). Furthermore, the elevation of mean arterial pressure (by radiotelemetry) in response to increased sodium intake was approximately twofold greater in the PID offspring (P<0.05).
  
  
  CONCLUSIONS
  PID results in increased visceral adiposity, which was associated with enhanced blood pressure responsiveness to dietary salt, perhaps due to programmed sedentary behavior.
authors.affiliation: Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Komolova
authors.forename: S L
authors.initials: SL
authors.lastname: Bourque
authors.forename: K
authors.initials: K
authors.lastname: Nakatsu
authors.forename: M A
authors.initials: MA
authors.lastname: Adams
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D049628:Body Size / Q000502:physiology; D005260:Female; D050152:Intra-Abdominal Fat / Q000473:pathology*; D000090463:Iron Deficiencies; D009043:Motor Activity / Q000502:physiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D017673:Sodium Chloride, Dietary / Q000494:pharmacology
chemical_list: D017673:Sodium Chloride, Dietary