The role of trehalose and its transporter in protection against reactive oxygen species.
During menadione stress, trehalose was necessary intracellularly, but under H2O2, the sugar was required on the outside of the plasma membrane. The mechanism of protection involves minimizing the oxidative damage caused to both proteins and lipids, which would require the presence of trehalose on both sides of the lipid bilayer.
da Costa Morato Nery
Débora
D
Departamento de Bioquímica, Instituto de Química, UFRJ, 21941-909 Rio de Janeiro, RJ, Brazil.
da Silva
Carmelita Gomes
CG
Mariani
Diana
D
Fernandes
Patrícia Neves
PN
Pereira
Marcos Dias
MD
Panek
Anita Dolly
AD
Eleutherio
Elis Cristina Araújo
EC
D005964:Glucosyltransferases / Q000235:genetics; D006861:Hydrogen Peroxide / Q000494:pharmacology; D015227:Lipid Peroxidation; D009004:Monosaccharide Transport Proteins / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress; D050050:Protein Carbonylation; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology*; D027981:Symporters / Q000235:genetics / Q000502:physiology*; D014199:Trehalose / Q000494:pharmacology / Q000502:physiology*; D024483:Vitamin K 3 / Q000494:pharmacology
D009004:Monosaccharide Transport Proteins; D016877:Oxidants; D017382:Reactive Oxygen Species; D029701:Saccharomyces cerevisiae Proteins; D027981:Symporters; C067575:maltose transport system, S cerevisiae; D024483:Vitamin K 3; D014199:Trehalose; D006861:Hydrogen Peroxide; D005964:Glucosyltransferases; C023180:trehalose-6-phosphate synthase