title: Long-term follow-up of Huntington disease treated by bilateral deep brain stimulation of the internal globus pallidus.
abstract: Deep brain stimulation is now accepted as a safe and efficient treatment for movement disorders including selected types of dystonia and dyskinesia. Very little, however, is known about its effect on other movement disorders, particularly for "choreic" movements. Huntington disease is a fatal autosomal-dominant neurodegenerative disorder characterized by movement disorders, progressive cognitive impairment, and psychiatric symptoms. Bilateral chronic stimulation of the internal globus pallidus was performed to control choreic movements in a 60-year-old man with a 10-year history of Huntington disease. Chronic deep brain stimulation resulted in remarkable improvement of choreic movements. Postoperative improvement was sustained after 4 years of follow-up with a marked improvement in daily quality of life.
authors.affiliation: Department of Neurosurgery, University Hospital Guy de Chauliac, Montpellier, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Biolsi
authors.forename: Laura
authors.initials: L
authors.lastname: Cif
authors.forename: Hassan El
authors.initials: HE
authors.lastname: Fertit
authors.forename: Santiago Gil
authors.initials: SG
authors.lastname: Robles
authors.forename: Philippe
authors.initials: P
authors.lastname: Coubes
mesh_terms: D046690:Deep Brain Stimulation; D005500:Follow-Up Studies; D005917:Globus Pallidus; D006801:Humans; D006816:Huntington Disease / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome