Reactive extraction of enantiomers of 1,2-amino alcohols via stereoselective thermodynamic and kinetic processes.
(R)-amino alcohol with an enantiomeric excess of >95% was resolved by reactive extraction processes from 2 equiv of racemic alcohol using a chiral receptor 2 as an enantioselective extractant. One resolution cycle is composed of three extractions: a stereoselective reversible imine formation, a stereoselective irreversible imine hydrolysis, and the recovery of 2 and enantiomeric amino alcohols.
Tang
Lijun
L
Division of Nano Sciences, Ewha Womans University, Seoul 120-750, South Korea.
Choi
Sujung
S
Nandhakumar
Raju
R
Park
Hyunjung
H
Chung
Hyein
H
Chin
Jik
J
Kim
Kwan Mook
KM
D000605:Amino Alcohols / Q000737:chemistry*; D007097:Imines / Q000737:chemistry; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism; D013816:Thermodynamics
D000605:Amino Alcohols; D007097:Imines