Monitoring Pc 4 photodynamic therapy in clinical trials of cutaneous T-cell lymphoma using noninvasive spectroscopy.
Silicon phthalocyanine Pc 4 photodynamic therapy (Pc 4-PDT) has emerged as a potentially effective treatment for cutaneous T-cell lymphoma (CTCL). Noninvasive reflectance and fluorescence spectroscopy before, during, and after PDT may provide useful dose metrics and enable therapy to be tailored to individual lesions. We present the design and implementation of a portable bedside spectroscopy system for initial clinical trials of Pc 4-PDT of CTCL. Reflectance and fluorescence spectra were obtained from an early stage CTCL patient throughout the course of the PDT treatment. Preliminary patient data show a significant effect of Pc 4 on the tissue absorption, modest Pc 4 photobleaching, and heterogeneity of Pc 4 within and between the lesions.
Lee
Tammy K
TK
University of Rochester, Institute of Optics and Department of Imaging Sciences, Rochester, New York 14642, USA.
Baron
Elma D
ED
Foster
Thomas H
TH
D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000188:drug therapy*; D017646:Organosilicon Compounds / Q000627:therapeutic use*; D010778:Photochemotherapy / Q000379:methods*; D011379:Prognosis; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D016896:Treatment Outcome
D007211:Indoles; D017646:Organosilicon Compounds; C082854:silicon phthalocyanine