title: [Low levels of 25-hydroxyvitamin D (25OHD) in patients with inflammatory bowel disease and its correlation with bone mineral density].
abstract: Patients with inflammatory bowel disease (IBD) are at risk of having vitamin D deficiency (25-OHD) and low bone mineral density (BMD).
  
  
  OBJECTIVE
  To measure 25OHD in a young group of IBD patients submitted to a clinical evaluation, routine biochemistry and BMD measurement (lumbar spine and proximal femur).
  
  
  RESULTS
  39 Crohn disease (CD) and 37 ulcerative colitis (UC) patients had lower serum levels of 25OHD compared to the control group (CD p = 0.003; UC p < 0.001), and 48.5% of the UC patients were 25OHD deficient. Lumbar spine BMD was lower in patients than controls (CD p = 0.001; UC p = 0.008). In CD patients, serum levels of 25OHD were significantly correlated with total femur (r = 0.391; p = 0.027) and femoral neck (r = 0.384; p = 0.03) BMD.
  
  
  CONCLUSIONS
  It was found lower levels of 25OHD and BMD in young IBD patients compared to normal controls, suggesting an important role of 25OHD deficiency in the pathogenesis of the IBD bone disease.
authors.affiliation: Serviço de Endocrinologia e Metabologia, Hospital de Clínicas, Universidade Federal do Paraná, PR, Brasil.
authors.forename: Hevelyn Noemberg de
authors.initials: HN
authors.lastname: Souza
authors.forename: Fabiana Lígia
authors.initials: FL
authors.lastname: Lora
authors.forename: Carolina A Moreira
authors.initials: CA
authors.lastname: Kulak
authors.forename: Nádila Cecyn Pietszkowski
authors.initials: NC
authors.lastname: Mañas
authors.forename: Heda M B
authors.initials: HM
authors.lastname: Amarante
authors.forename: Victória Z Cochenski
authors.initials: VZ
authors.lastname: Borba
mesh_terms: D000328:Adult; D015519:Bone Density; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000097:blood* / Q000150:complications; D003424:Crohn Disease / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D