title: Peripheral T lymphocytes recirculating back into the thymus can mediate thymocyte positive selection.
abstract: The thymus continuously produces T lymphocytes that contribute to the maintenance of the peripheral T cell pool. Since peripheral recirculating T cells represent a very minor population among total thymocytes in normal animals, the relationship between the thymus and secondary lymphoid organs is generally considered unidirectional. Recently, several reports have described the presence of recirculating T cells in the thymus, raising issues regarding their possible function. In this article, we show that the niche for recirculating T cells in the thymus, i.e., their absolute number, is the same in lymphopenic and normal mice. Using a novel combination of TCR-transgenic mice in which the ligand necessary for positive selection of host T cells is only expressed by transferred donor T cells, we show that mature T cells recirculating back to the thymus can mediate positive selection.
authors.affiliation: Max Planck Institute of Immunobiology, Freiburg, Germany;
authors.forename: Jörg
authors.initials: J
authors.lastname: Kirberg
authors.forename: Nabil
authors.initials: N
authors.lastname: Bosco
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Deloulme
authors.forename: Rod
authors.initials: R
authors.lastname: Ceredig
authors.forename: Fabien
authors.initials: F
authors.lastname: Agenès
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D008822:Mice, Transgenic; D010227:Parabiosis; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D013950:Thymus Gland / Q000276:immunology* / Q000502:physiology