title: Growth of microbial populations in nonminimal media: some considerations for modeling.
abstract: Ramkrishna and his co-workers have developed so-called cybernetic models which purport to describe, among other things, how microorganisms make choices when presented with two or more functionally equivalent, or substitutable, nutrients that are sources of carbon and available energy. In general, however, organisms are presented with choices not just between nutrients that are substitutable for one another, but also between sets of nutrients some of which are by no means substitutable for one another. It is postulated herein that the main ideas of cybernetic modeling apply to these more general choices as they seem to apply to the choices considered by Ramkrishna and his co-workers. Some consequences of the postulate are worked out for steady-state growth situations where two, or in one case three, nutrients limit or potentially limit growth rate. If predicted phenomena are observed experimentally so as to verify the postulate, a significantly improved basis for understanding growth of microorganisms in practical fermentation media as well as in natural situations will be provided by this application of cybernetic modeling ideas.
authors.affiliation: Institute of Chemical Engineering and High Temperature Chemical Processes and Department of Chemical Engineering, University of Patras, GR-26110 Patras, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Pavlou
authors.forename: A G
authors.initials: AG
authors.lastname: Fredrickson