The origins of blood: induction of hematopoietic stem cells from different sources.
Ex vivo hematopoiesis from embryonic sources offers exciting promises in basic research and medicine. In this issue of Cell Stem Cell, Ledran et al. (2008) describe human embryonic stem cell (hESC)-derived hematopoiesis, while Taoudi et al. (2008) define the origin of definitive hematopoietic stem cells (HSCs) from the mouse aorta-gonad-mesonephros (AGM) region.
Saito
Yoriko
Y
Research Unit for Human Disease Models, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Ishikawa
Fumihiko
F
D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D001769:Blood; D015820:Cadherins / Q000502:physiology; D002454:Cell Differentiation; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D017493:Leukocyte Common Antigens / Q000502:physiology; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D017154:Stromal Cells / Q000166:cytology* / Q000502:physiology*; D000099152:Cadherin 5
D015703:Antigens, CD; D015820:Cadherins; D017493:Leukocyte Common Antigens; D000099152:Cadherin 5