Understanding the nature of prion diseases using cell-free assays.
A central event in the transmission and pathogenesis of transmissible spongiform encephalopathy diseases is the misfolding of the prion protein. Considerable progress has been made in our understanding of this misfolding event through the development of cell-free assays that mimic the molecular features of prion propagation. This chapter reviews the contribution of cell-free assays to our understanding of prion propagation.
Lawson
Victoria A
VA
Department of Pathology and Mental Health Research Institute of Victoria, University of Melbourne, Melbourne, Australia.
D000818:Animals; D001681:Biological Assay / Q000379:methods*; D002474:Cell-Free System; D006801:Humans; D017096:Prion Diseases / Q000378:metabolism* / Q000473:pathology*; D011328:Prions / Q000378:metabolism*
D011328:Prions