title: Synthetic studies on (+)-manzamine A: stereoselective synthesis of the tetracyclic core framework.
abstract: The stereoselective synthesis of the tetracyclic intermediate 3 for (+)-manzamine A (1) has been achieved. The key features of this stereoselective synthesis of 3 are the Rh-catalyzed asymmetric hydrogenation and a diastereoselective intermolecular Diels-Alder reaction. The 8-membered ring is efficiently constructed utilizing our Ns-strategy.
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kita
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Toma
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kan
authors.forename: Tohru
authors.initials: T
authors.lastname: Fukuyama
mesh_terms: D002227:Carbazoles / Q000138:chemical synthesis*; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D002227:Carbazoles; D011083:Polycyclic Compounds; C078290:manzamine A