title: A positron-probe system for arterial input function quantification for positron emission tomography in humans.
abstract: We developed an intra-arterial positron-probe (beta(+)-probe) system to measure the arterial time-activity concentration in humans for quantitative compartmental modeling of positron emission tomography studies. Performance was characterized in vitro, by using a uniform phantom to calculate dead time, linearity, and absolute detector sensitivity. In vitro evaluations in a uniform phantom showed a system dead time of 2.5 micros, linear regression between measured and true count rates with R(2)=0.999, and detector sensitivity of 6.9-7.0 counts/s kBq(-1) ml. These met or exceeded values of previously reported systems.
authors.affiliation: Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
authors.forename: Kihak
authors.initials: K
authors.lastname: Lee
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
authors.forename: Jack L
authors.initials: JL
authors.lastname: Lancaster
authors.forename: Paul A
authors.initials: PA
authors.lastname: Jerabek
mesh_terms: D000792:Angiography / Q000295:instrumentation* / Q000379:methods; D001158:Arteries; D006801:Humans; D049268:Positron-Emission Tomography / Q000295:instrumentation* / Q000379:methods; D011849:Radioactive Tracers
chemical_list: D011849:Radioactive Tracers