title: The effects of sulfurous-arsenical-ferruginous thermal water nasal irrigation in wound healing after functional endoscopic sinus surgery for chronic rhinosinusitis: a prospective randomized study.
abstract: OBJECTIVE
  Although several publications reported the benefits of nasal irrigation in the management of chronic rhinosinusitis and in sinonasal postoperative care, the available data are poorly controlled. The aim of this prospective randomized study was to compare the effects of sulfurous-arsenical-ferruginous thermal water nasal irrigation vs isotonic sodium chloride solution nasal irrigation after functional endoscopic sinus surgery (FESS) for chronic sinonasal disease considering the histomorphological characteristics of mucosal repair after sinus surgery.
  
  
  METHODS
  Eighty patients who consecutively underwent FESS were randomly assigned (1:1) to postoperative nasal irrigation with sulfurous-arsenical-ferruginous thermal water or isotonic sodium chloride solution for 6 months. Intraoperative and postoperative (1, 3, and 6 months) mean counts of lymphocytes, neutrophils, eosinophils, plasma cells, histiocytes, and mast cells in ethmoid biopsies were blindly determined by a pathologist.
  
  
  RESULTS
  Fifty-six patients underwent at least 2 postoperative biopsies. A statistically significant reduction of eosinophil count was disclosed 6 months postoperatively only after sulfurous-arsenical-ferruginous solution nasal irrigation (P = .04). After isotonic sodium chloride solution nasal irrigation, the mean eosinophil count in 6-month postoperative biopsies did not decrease. After both irrigation modalities, the mean mast cell counts in 6-month postoperative biopsies were significantly lower than in intraoperative biopsies (P < .05). Neutrophils, lymphocytes, histiocytes, and plasma cell counts were not significantly different between intraoperative vs 6-month postoperative biopsies independently from irrigation modality.
  
  
  CONCLUSIONS
  Considering the important role of eosinophils in allergic response, we should suggest sulfurous-arsenical-ferruginous solution nasal irrigation in particular, which significantly reduces local eosinophil count, for allergic patients after FESS for chronic rhinosinusitis.
authors.affiliation: Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Padua, Italy. alberto.staffieri@unipd.it
authors.forename: Alberto
authors.initials: A
authors.lastname: Staffieri
authors.forename: Filippo
authors.initials: F
authors.lastname: Marino
authors.forename: Claudia
authors.initials: C
authors.lastname: Staffieri
authors.forename: Luciano
authors.initials: L
authors.lastname: Giacomelli
authors.forename: Emiliano
authors.initials: E
authors.lastname: D'Alessandro
authors.forename: Silvia
authors.initials: S
authors.lastname: Maria Ferraro
authors.forename: Umberto
authors.initials: U
authors.lastname: Fedrazzoni
authors.forename: Gino
authors.initials: G
authors.lastname: Marioni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001151:Arsenic; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002908:Chronic Disease; D004724:Endoscopy; D005005:Ethmoid Sinus / Q000473:pathology; D005260:Female; D006358:Hot Temperature; D006801:Humans; D007552:Isotonic Solutions; D008297:Male; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000601:surgery*; D011182:Postoperative Care / Q000379:methods; D011446:Prospective Studies; D012852:Sinusitis / Q000601:surgery*; D012965:Sodium Chloride; D013455:Sulfur; D007507:Therapeutic Irrigation / Q000379:methods*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D007552:Isotonic Solutions; C418212:ferruginine; D012965:Sodium Chloride; D013455:Sulfur; D001151:Arsenic