title: Ligand-free Sonogashira coupling reactions with heterogeneous Pd/C as the catalyst.
abstract: A variety of aryl iodides were coupled with aromatic and aliphatic terminal alkynes to give the corresponding 1,2-disubstituted aromatic alkynes in good yields by using only 0.4 mol % of the heterogeneous 10 % Pd/C as the catalyst without a ligand, copper salt, or amine in an aqueous medium.
authors.affiliation: Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 6-1, Mitahora-higashi 5-chome, Gifu, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Mori
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Yanase
authors.forename: Satoka
authors.initials: S
authors.lastname: Aoyagi
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Monguchi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Maegawa
authors.forename: Hironao
authors.initials: H
authors.lastname: Sajiki
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D008024:Ligands; D008968:Molecular Conformation; D010100:Oxygen / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D013696:Temperature
chemical_list: D008024:Ligands; D010165:Palladium; D002244:Carbon; D010100:Oxygen