RNA interference: endogenous siRNAs derived from transposable elements.
The Piwi-interacting RNA interference pathway plays an important role in suppressing transposable elements in the Drosophila germline. Now, deep sequencing of short RNAs from somatic tissue and cell culture has identified a novel class of endogenous siRNAs that may have a similar role in the soma.
Obbard
Darren J
DJ
Institute of Evolutionary Biology, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK.
Finnegan
David J
DJ
D000818:Animals; D060565:Argonaute Proteins; D004251:DNA Transposable Elements; D004330:Drosophila / Q000378:metabolism*; D029721:Drosophila Proteins; D011506:Proteins / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism*; D034743:RNA-Induced Silencing Complex
D060565:Argonaute Proteins; D004251:DNA Transposable Elements; D029721:Drosophila Proteins; D011506:Proteins; D034741:RNA, Small Interfering; D034743:RNA-Induced Silencing Complex; C116498:piwi protein, Drosophila