title: Prevalence and pathophysiological mechanisms of elevated cardiac troponin I levels in a population-based sample of elderly subjects.
abstract: OBJECTIVE
  To evaluate the prevalence of cardiac troponin I (cTnI) elevation in an elderly community population and the association of cTnI levels with cardiovascular risk factors, vascular inflammation, atherosclerosis, cardiac performance, and areas indicative of infarcted myocardium identified by cardiac magnetic resonance imaging.
  
  
  RESULTS
  cTnI elevation defined as cTnI levels >0.01 microg/L (Access AccuTnI, Beckman Coulter) was found in 21.8% of the study participants (n = 1005). cTnI > 0.01 microg/L was associated with cardiovascular high-risk features, the burden of atherosclerosis in the carotid arteries, left-ventricular mass, and impaired left-ventricular systolic function. No associations were found between cTnI and inflammatory activity, diastolic dysfunction, or myocardial scars. Male gender (OR 1.6; 95% CI 1.1-2.4), ischaemic ECG changes (OR 1.7; 95% CI 1.1-2.7), and NT-pro-brain natriuretic peptide levels (OR 1.4; 95% CI 1.1-1.7) independently predicted cTnI > 0.01 microg/L. cTnI > 0.01 microg/L correlated also to an increased cardiovascular risk according to the Framingham risk score.
  
  
  CONCLUSIONS
  cTnI > 0.01 microg/L is relatively common in elderly subjects and is associated with cardiovascular high-risk features and impaired cardiac performance. Cardiac troponin determined by a highly sensitive assay might thus serve as an instrument for the identification of subjects at high cardiovascular risk in general populations.
authors.affiliation: Department of Medical Sciences, Cardiology, Uppsala University Hospital, S-751 85 Uppsala, Sweden. kai.eggers@ucr.uu.se
authors.forename: Kai M
authors.initials: KM
authors.lastname: Eggers
authors.forename: Lars
authors.initials: L
authors.lastname: Lind
authors.forename: Håkan
authors.initials: H
authors.lastname: Ahlström
authors.forename: Tomas
authors.initials: T
authors.lastname: Bjerner
authors.forename: Charlotte
authors.initials: C
authors.lastname: Ebeling Barbier
authors.forename: Anders
authors.initials: A
authors.lastname: Larsson
authors.forename: Per
authors.initials: P
authors.lastname: Venge
authors.forename: Bertil
authors.initials: B
authors.lastname: Lindahl
mesh_terms: D000368:Aged; D002340:Carotid Artery Diseases / Q000097:blood / Q000175:diagnosis*; D017023:Coronary Angiography / Q000379:methods; D052279:Creatine Kinase, MB Form / Q000097:blood*; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D009206:Myocardium / Q000378:metabolism*; D018570:Risk Assessment; D019210:Troponin I / Q000097:blood* / Q000378:metabolism; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000175:diagnosis*
chemical_list: D019210:Troponin I; D052279:Creatine Kinase, MB Form