title: High-dose-rate brachytherapy in a large squamous cell carcinoma of the hand.
abstract: OBJECTIVE
  High-dose-rate (192)Ir-based brachytherapy can be used as an exclusive treatment of large skin tumors when teletherapy or surgery is not feasible. A case of an extended inoperable skin epithelioma of the hand is reported; the lesion involved the first finger, the tenar, the palm, and the back.
  
  
  METHODS
  A detailed description of an individual case is reported. A customized mold was created for the patient, to administer a fractionated brachytherapy treatment in a reproducible way.
  
  
  RESULTS
  A total dose of 50Gy was administered in 10 fractions, after a time schedule of three fractions per week. The treatment was well tolerated and the acute effects (mainly, epitheliolysis) were resolved completely within a month after the treatment.
  
  
  CONCLUSIONS
  Nine months after the treatment, the malignant lesion completely disappeared and the cosmetic results are quite satisfactory. Therefore, we conclude that the treatment technique is well adaptable to any particular geometry and that the fractionation scheme has proven to be well tolerated and effective in tumor eradication.
authors.affiliation: Department of Oncology, Pisa University, and Division of Radiotherapy, Azienda Ospedaliera Universitaria Pisana, via Roma 67, Pisa, Italy. m.fabrini@ao-pisa.toscana.it
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Fabrini
authors.forename: Franco
authors.initials: F
authors.lastname: Perrone
authors.forename: Mario
authors.initials: M
authors.lastname: De Liguoro
authors.forename: Luca
authors.initials: L
authors.lastname: Cionini
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006225:Hand / Q000473:pathology*; D006801:Humans; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012878:Skin Neoplasms / Q000532:radiotherapy*