Prevalence of adverse drug combinations in a large post-mortem toxicology database.
The prevalence of important adverse drug combinations was studied among the 37,367 cases included in the Finnish post-mortem toxicology database during 2000-2006. The new SFINX interaction database (Swedish, Finnish, INteraction X-referencing) was utilised to identify adverse drug combinations. Consequently, the 24 drugs chosen for the study generated 96 two-compound combinations possessing potentially severe interactions. The total number of hits for the combinations found in the post-mortem database was 267, which accounts for approximately 0.71% of all cases. The potential role of adverse drug interaction (ADI) in these cases was evaluated from the background information and death certificate. The possible ADI cases comprised 23% of all hits and 0.17% of all cases analysed. In cases with a pharmacodynamic mechanism, the most prominent combinations were medicines causing serotonin syndrome or a beta(1)-blocker with verapamil or diltiazem. In cases with a pharmacokinetic mechanism, half of the cases involved digoxin in combination with verapamil. In one third of the possible ADI cases, a forensic pathologist had noted the studied compounds as an underlying or contributing cause of death, although the agents' specific role in ADIs was rarely recognised.
Launiainen
Terhi
T
Department of Forensic Medicine, University of Helsinki, P.O. Box 40, 00014, Helsinki, Finland. terhi.launiainen@helsinki.fi
Vuori
Erkki
E
Ojanperä
Ilkka
I
D016907:Adverse Drug Reaction Reporting Systems; D002423:Cause of Death; D016208:Databases, Factual; D004347:Drug Interactions; D005260:Female; D005387:Finland; D053593:Forensic Toxicology; D006801:Humans; D008297:Male; D008875:Middle Aged