Toxicity on the luminescent bacterium Vibrio fischeri (Beijerinck). I: QSAR equation for narcotics and polar narcotics.
Toxicity data on chemicals, supposed to have a narcotic or polar narcotic toxicological mode of action, have been produced on the luminescent bacterium Vibrio fischeri using the Microtox test procedure. Advanced statistical methods have been used to calculate statistically sound values for ecotoxicological endpoints. Simple quantitative structure activity relationship (QSAR) equations were developed for narcotics and polar narcotics. These equations were compared with those proposed by the European Technical Guidance Document on Risk Assessment for other aquatic organisms (algae, Daphnia, and fish). Similarities and differences are discussed. The need for including the bacterial component in the ecotoxicological risk assessment for aquatic ecosystems is highlighted.
Vighi
Marco
M
Department of Environmental Sciences, University of Milano Bicocca, Piazza della Scienza 1, I-20126Milano, Italy. Electronic address: marco.vighi@unimib.it.
Migliorati
Sonia
S
Department of Statistics, University of Milano Bicocca, Via Bicocca degli Arcimboldi 8, 20126 Milano, Italy.
Monti
Gianna Serafina
GS
Department of Statistics, University of Milano Bicocca, Via Bicocca degli Arcimboldi 8, 20126 Milano, Italy.
D048908:Aliivibrio fischeri / Q000187:drug effects*; D000818:Animals; D017753:Ecosystem; D056890:Eukaryota / Q000187:drug effects / Q000382:microbiology; D005399:Fishes / Q000382:microbiology; D009294:Narcotics / Q000494:pharmacology*; D021281:Quantitative Structure-Activity Relationship; D012623:Seawater; D012996:Solutions; D013329:Structure-Activity Relationship
D009294:Narcotics; D012996:Solutions