title: Determination of serologic and colostral response in late-gestation cows vaccinated with a Mycoplasma bovis bacterin.
abstract: OBJECTIVE
  To determine whether vaccinating cows during late gestation against Mycoplasma bovis will result in adequate concentrations of M bovis-specific IgG(1) in serum, colostrum, and milk.
  
  
  METHODS
  78 dairy cows.
  
  
  METHODS
  Serum samples were obtained 60 and 39 days prior to expected parturition in vaccinated and control cows from a single herd. Serum and colostrum samples were also obtained at parturition. Milk samples were obtained 7 to 14 days after parturition. Samples were analyzed for anti-M bovis IgG(1) concentrations.
  
  
  RESULTS
  Prior to vaccination, control and vaccinated cows had similar anti-M bovis IgG(1) concentrations. After initial vaccination and subsequent booster and at parturition, there was a significant difference between the 2 groups, with vaccinated cows having higher IgG concentrations. Colostrum from vaccinated cows had higher anti-M bovis IgG(1) concentrations, compared with control cows; however, IgG(1) concentrations in milk did not differ between the 2 groups.
  
  
  CONCLUSIONS
  Vaccination of late-gestation cows resulted in increased concentrations of anti-M bovis IgG(1) in colostrum. However, ingestion of colostrum by calves may not guarantee protection against M bovis infection.
authors.affiliation: Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Calloway
authors.forename: Loren G
authors.initials: LG
authors.lastname: Schultz
authors.forename: Munashe
authors.initials: M
authors.lastname: Chigerwe
authors.forename: Robert L
authors.initials: RL
authors.lastname: Larson
authors.forename: Robert S
authors.initials: RS
authors.lastname: Youngquist
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Steevens
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000097:blood; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000382:microbiology* / Q000517:prevention & control; D003126:Colostrum / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood; D008892:Milk / Q000382:microbiology; D009175:Mycoplasma Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D045682:Mycoplasma bovis / Q000276:immunology*; D011247:Pregnancy; D012044:Regression Analysis; D014611:Vaccination / Q000662:veterinary*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007074:Immunoglobulin G