[Bone histomorphometry of lactating and no lactating hyperthyroid rats].
The objective of this study was to verify if hyperthyroidism potentiates the osteopenia lactational. 24 adult female rats were distributed in four groups: euthyroid no lactating (control), euthyroid lactating, hyperthyroid no lactating and hyperthyroid lactating. 20 days after gestation, all the animals were necropsied. The thoracic and lumbar vertebrae, the femur and tibia were decalcified and processed for histomorphometric analysis. The euthyroid lactating group presented intense osteopenia in the studied bones. In the hyperthyroid no lactating group, there was not any change in trabecular bone percentage in none of the analyzed bone. In the hyperthyroid lactating group, there was osteopenia in the tibia and femur, similar to the one in the euthyroid lactating group. But the trabecular bone percentage in all the vertebral bodies was significantly larger in comparison with the euthyroid lactating group. It was concluded that the hyperthyroidism does not potentiate the osteopenia lactational in female rats, but it minimizes the vertebral osteopenia once it stimulates the osteoblastic activity.
Serakides
Rogéria
R
Setor de Patologia, Departamento de Clínica e Cirurgia Veterinárias, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. serakide@dedalus.lcc.ufmg.br
Ocarino
Natália de Melo
Nde M
Magalhães
Fernanda do Carmo
Fdo C
Souza
Cíntia de Almeida
Cde A
Leite
Eveline Dias
ED
Freitas
Edmilson Santos de
ES
D000818:Animals; D001851:Bone Diseases, Metabolic / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005260:Female; D006980:Hyperthyroidism / Q000150:complications*; D007774:Lactation; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D013974:Thyroxine / Q000627:therapeutic use
D013974:Thyroxine