Cytotoxic activity of diterpenoids isolated from the aerial parts of Elaeoselinum asclepium subsp. meoides.
The phytochemical investigation of the acetone extract of the aerial parts of Elaeoselinum asclepium (L.) Bertol. subsp. meoides (Desf.) Fiori afforded several known diterpenoids as well as meoidic acid ( 5), new in the literature. The cytotoxic activities of elasclepic acid ( 1), ENT-atis-16-en-19-oic acid ( 2), ent-beyer-15-en-19-oic acid ( 3), ent-kaur-16-en-19-oic acid ( 4) and meoidic acid ( 5) were investigated on rat glioma C6 cells by evaluation of cell growth inhibition.
Rosselli
Sergio
S
Dipartimento di Chimica Organica, Università degli Studi di Palermo, Palermo, Italy.
Maggio
Antonella
A
Eiroa
Cristina
C
Formisano
Carmen
C
Bruno
Maurizio
M
Irace
Carlo
C
Maffettone
Carmen
C
Mascolo
Nicola
N
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D019661:Apiaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D051381:Rats
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes