title: Periodic operation of a continuous culture of Baker's yeast.
abstract: The possibility of enhancing the biomass productivity of a continuous culture of Saccharomyces cerevisiae growing on a glucose-limited medium is addressed. An unstructured Monod-type model is first identified using steady-state data. The culture is subjected to step changes in dilution rate, and it is seen that the Monod model is unable to predict even qualitatively the dynamic response of the culture. Incorporation of a time delay allows significant improvement in the transient fit. It is found that the culture has a time lag of about 3 h in adapting its growth rate. Cycling the dilution rate with a period of 3 h leads to substantial improvement in the average biomass productivity.
authors.affiliation: Department of Chemical Engineering, University of Florida, Gainesville, Florida 32611, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Abulesz
authors.forename: G
authors.initials: G
authors.lastname: Lyberatos