Longitudinal MRI evaluations of human global cortical thickness over minutes to weeks.
Magnetic resonance imaging (MRI) was used to evaluate within-subject variability in global mean cortical thickness over test-retest intervals of minutes-weeks in five healthy adults. Within-subject measures of global mean thickness were consistent over these intervals. Test-retest assessments of absolute thickness differences and percent thickness differences indicated variations of, respectively, < or =0.05-0.06 mm and < or =+/-1.9-2.3%. There have been few evaluations of normal within-subject variations in cortical thickness. The present results suggest that within-subject variability in global mean cortical thickness can be low over test-retest intervals of minutes-weeks, and that longitudinal scans can establish useful baseline estimates of variability from which to assess changes due to injury, disease, or other experiences.
Wang
Xin
X
Department of Neuroscience, University of Toledo Medical Center, Toledo, OH 43614, USA.
Bauer
William
W
Chiaia
Nicolas
N
Dennis
Michael
M
Gerken
Mischka
M
Hummel
Jacob
J
Kane
John
J
Kenmuir
Cynthia
C
Khuder
Sadik
S
Lane
Richard
R
Mooney
Richard
R
Bazeley
Peter
P
Apkarian
Vania
V
Wall
John
J
D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D013997:Time Factors