Increased circulating pro-inflammatory cytokines and imbalanced regulatory T-cell cytokines production in chronic idiopathic urticaria.
The immunologic characterization of chronic idiopathic urticaria (CIU), mainly regarding cytokine profile needs more investigation. We examined circulating inflammatory cytokine levels, T-cell induced secretion, and cytokine mRNA expression in patients with CIU subjected to the intradermal autologous serum skin test (ASST). Increased levels of circulating pro-inflammatory cytokines, such as TNF-alpha, IL-1beta, IL-12p70, and IL-6 have been observed in most of patients with CIU, together with an enhancement of IL-2 secretion following T-cell stimulation. Highlighting the inflammatory profile in CIU found in ASST positive, is the enhanced B-cell proliferative responsiveness and increased IL-17 secretion levels. ASST-positive patients also exhibited impaired IL-4 secretion associated with increased IL-10 production. Altered cytokine expression in patients with ASST-negative, was the down-modulation of spontaneous IL-10 mRNA expression levels in peripheral blood mononuclear cells. Our findings support the concept of immunologic dysregulation in CIU, revealing a systemic inflammatory profile associated with disturbed cytokine production by T cells, mainly related to IL-17 and IL-10 production.
Dos Santos
Juliana Cristina
JC
Laboratory of Dermatology and Immunodeficiencies (LIM-56), Department of Dermatology, Medical School of the University of São Paulo, São Paulo, Brazil.
Azor
Mayce Helena
MH
Nojima
Viviane Yoshimi
VY
Lourenço
Francinelson Duarte
FD
Prearo
Erica
E
Maruta
Celina Wakisaka
CW
Rivitti
Evandro Ararigbóia
EA
da Silva Duarte
Alberto José
AJ
Sato
Maria Notomi
MN
D000328:Adult; D002908:Chronic Disease; D016207:Cytokines / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D008934:Mitogens / Q000633:toxicity; D012333:RNA, Messenger / Q000378:metabolism; D014581:Urticaria / Q000097:blood* / Q000378:metabolism
D016207:Cytokines; D008934:Mitogens; D012333:RNA, Messenger