Deregulating EMT and senescence: double impact by a single twist.
The acquisition of a fully malignant phenotype is limited by several barriers, including cellular senescence and the requirement to undergo an epithelial-mesenchymal transition (EMT). Deregulation of these processes is believed to occur by largely independent events. In this issue of Cancer Cell, Ansieau et al. (2008) challenge this view.
Smit
Marjon A
MA
Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Peeper
Daniel S
DS
D000818:Animals; D054338:Cell Transdifferentiation / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016922:Cellular Senescence / Q000235:genetics; D004789:Enzyme Activation; D004847:Epithelial Cells / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D005347:Fibroblasts / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D042361:Mammary Glands, Human / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D016160:Retinoblastoma Protein / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D051879:Twist-Related Protein 1 / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation; D018631:ras Proteins / Q000378:metabolism
D009687:Nuclear Proteins; D012097:Repressor Proteins; D016160:Retinoblastoma Protein; C103173:TWIST1 protein, human; C486274:TWIST2 protein, human; D016159:Tumor Suppressor Protein p53; D051879:Twist-Related Protein 1; D018631:ras Proteins