Fluorescent probes and labels for biomedical applications.
Fluorescence probes and labels have become indispensable tools for clinical diagnostics, high-throughput screening, and other biomedical applications. We have developed several classes of new squaraine-based red and near-infrared (NIR) probes and labels (SETA and Square series), naphthalimide-based fluorescence lifetime dyes (SeTau series), and cyanine- and squaraine-based quenchers (SQ series). This report discusses the spectral and photophysical properties of these new markers. In particular, the red and NIR dyes of the SETA and Square series are extremely bright, with photostabilities that are unmatched by any other dyes in the same spectral region.
Patsenker
Leonid
L
State Scientific Institution Institute for Single Crystals of the National Academy of Sciences of Ukraine, 60 Lenin Ave., 61001 Kharkov, Ukraine. patsenker@isc.kharkov.com
Tatarets
Anatoliy
A
Kolosova
Olga
O
Obukhova
Olena
O
Povrozin
Yevgeniy
Y
Fedyunyayeva
Iryna
I
Yermolenko
Inna
I
Terpetschnig
Ewald
E
D000818:Animals; D002417:Cattle; D003503:Cyclobutanes / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007074:Immunoglobulin G / Q000737:chemistry; D008027:Light; D008956:Models, Chemical; D010636:Phenols / Q000737:chemistry*; D010777:Photochemistry / Q000379:methods; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D012709:Serum Albumin / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013997:Time Factors
D003503:Cyclobutanes; D005456:Fluorescent Dyes; D007074:Immunoglobulin G; D010636:Phenols; D012709:Serum Albumin; C480596:squaraine