Vascular actions of the prostacyclin receptor antagonist BAY 73-1449 in the portal hypertensive rat.
We have investigated the actions of the postacyclin receptor antagonist BAY 73-1449 on shunt vessel development and shunt flow in the portal vein ligated portal hypertensive Wistar rat in vivo. BAY 73-1449 (0.1-1 mg/kg), given intravenously, did not significantly reduce mesenteric inflow, but significantly reduced splenic shunt vessel outflow, compared to the effects of vehicle, in anaesthetized portal vein ligated rats as measured by shunt vessel conductance. There were no differences between portal vein ligated animals treated, beginning just before portal vein ligation, with vehicle for 7 days and animals treated for 7 days with BAY 73-1449 (1-5 mg/kg, s.c.) in the degree of porto-systemic shunting, as measured by the radioactive microsphere technique in anaesthetized rats. Portal pressure was similar in animals treated with vehicle or BAY 73-1449. It is concluded that the prostacyclin receptor antagonist BAY 73-1449 can acutely reduce shunt vessel blood flow in portal hypertensive rats.
Bexis
Sotiria
S
Department of Physiology, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.
McCormick
P Aiden
PA
Docherty
James R
JR
D000818:Animals; D006975:Hypertension, Portal / Q000503:physiopathology*; D008297:Male; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D017082:Portal Pressure / Q000187:drug effects; D011168:Portal System / Q000187:drug effects* / Q000502:physiology; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D044006:Receptors, Epoprostenol / Q000037:antagonists & inhibitors*; D013152:Splanchnic Circulation / Q000187:drug effects
C532175:N-6-(4-(benzyloxy)phenyl)pyrimidin-4-ylphenylalanine; D011743:Pyrimidines; D044006:Receptors, Epoprostenol; D010656:Phenylephrine; D010649:Phenylalanine