Complete genome analysis of a highly pathogenic H5N1 influenza A virus isolated from a tiger in China.
An influenza A virus (A/Tig/SH/01/2005 (H5N1) was isolated from lung tissue samples of a dead zoo tiger with respiratory disease in China in July 2005. Complete genome analysis indicated that the isolate was highly identical to an H5N1 virus isolated from a migratory duck at Poyang lake in China in that year. The genotype of the isolate was K,G,D,5J,F,1J,F,1E, and phylogenetically it was a clade 2.2 virus. Molecular characterization of all of the gene segments revealed characteristics of highly pathogenic influenza A viruses. These results may help to identify molecular determinants of virulence and highlight the necessity for continuous surveillance.
Mushtaq
Muhammad Hassan
MH
Key Laboratory of Animal Diseases Diagnostic and Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Ministry of Agriculture, Nanjing, China.
Juan
Huang
H
Jiang
Ping
P
Li
Yufeng
Y
Li
TianXian
T
Du
Yijun
Y
Mukhtar
Muhammad Mahmood
MM
D000818:Animals; D002681:China / Q000453:epidemiology; D004372:Ducks / Q000821:virology; D005814:Genes, Viral; D016679:Genome, Viral; D005838:Genotype; D053124:Influenza A Virus, H5N1 Subtype / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D009976:Orthomyxoviridae Infections / Q000662:veterinary* / Q000821:virology*; D046010:Tigers / Q000821:virology*; D014774:Virulence / Q000235:genetics