title: Clinical presentation and patterns of slow transit constipation do not predict coexistent upper gut dysmotility.
abstract: BACKGROUND
  Slow transit constipation (STC) is associated with upper gastrointestinal tract motor abnormalities in a subset of patients. This could influence the clinical approach, particularly in those rare cases where surgical management is considered.
  
  
  OBJECTIVE
  To identify factors that predict proximal gut dysmotility in patients with STC.
  
  
  METHODS
  Esophageal and small bowel motor function were evaluated in 77 patients with STC. Severity and pattern of colonic transit delay, prevalence of a co-existent rectal evacuatory disorder, and type (if present), and duration, and onset of constipation symptoms were compared.
  
  
  RESULTS
  Of the 77 patients studied, 43% exhibited altered motor function in the esophagus and/or small bowel. Frequency of defecation was lower in these patients than in those without upper gastrointestinal dysmotility (0.5 +/- 0.1 vs. 1.3 +/- 0.3 bowel movements/per week, respectively; P = 0.04). Severity and patterns of colonic transit delay and the mechanism associated with the onset of constipation symptoms or with their duration were similar in subjects with or without upper gastrointestinal tract dysmotility. Small bowel but not esophageal motor dysfunction was more frequently associated with a co-existent rectal evacuatory disorder (P = 0.01).
  
  
  CONCLUSIONS
  Upper gastrointestinal tract dysmotility in patients with STC is frequent, but prediction on the basis of clinical history and characteristics of colonic transit is problematic.
authors.affiliation: Centre for Academic Surgery (GI Physiology Unit), Barts and The London Queen Mary's School of Medicine and Dentistry, London, UK. zaratenatalia1@yahoo.es
authors.forename: Natalia
authors.initials: N
authors.lastname: Zarate
authors.forename: Charlie H
authors.initials: CH
authors.lastname: Knowles
authors.forename: Etsuro
authors.initials: E
authors.lastname: Yazaki
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Lunnis
authors.forename: S Mark
authors.initials: SM
authors.lastname: Scott
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003248:Constipation / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D015154:Esophageal Motility Disorders / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000000981:diagnostic imaging; D005772:Gastrointestinal Transit / Q000502:physiology*; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012720:Severity of Illness Index; D055815:Young Adult