Csp3-F bond activation by nucleophilic attack of the {Pt2S2} core assisted by non-covalent interactions.
The high nucleophilicity of the sulfur atoms in [Pt(2)(dppp)(2)(micro-S)(2)] triggers a C-F activation process in 1,3-difluoro-2-propanol that leads to the [Pt(2)(dppp)(2)(micro-S)(micro-SCH(2)CH(OH)CH(2)F]F product through a S(N)2 mechanism, where the O-HF hydrogen bond established from the alcohol group of the organic substrate is essential for assisting the departure of the fluoride anion.
Nova
Ainara
A
Departament de Química, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Catalonia, Spain.
Mas-Ballesté
Rubén
R
Ujaque
Gregori
G
González-Duarte
Pilar
P
Lledós
Agustí
A