Dangerous liaisons: the apoptotic engulfment receptor CED-1 links innate immunity to the unfolded protein response.
In this issue of Developmental Cell, Haskins et al. describe a molecular link between an apoptotic cell receptor, a branch of the unfolded protein response, and innate immunity. The finding that the plasma membrane phagocytic receptor CED-1 promotes the expression of unfolded response genes suggests a novel regulatory mechanism for the control of this primitive immune system that may couple the presence of pathogen with the production of secreted antimicrobial effectors.
Lamitina
Todd
T
Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA. lamitina@mail.med.upenn.edu
Cherry
Sara
S
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000502:physiology*; D004926:Escherichia coli / Q000472:pathogenicity; D005796:Genes; D007113:Immunity, Innate; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D009154:Mutation; D017510:Protein Folding; D019779:Salmonella enterica / Q000472:pathogenicity
D029742:Caenorhabditis elegans Proteins; D008565:Membrane Proteins; C422043:ced-1 protein, C elegans