Lack of early augmentation of platelet reactivity after coronary intervention in patients treated with bivalirudin.
To determine whether a regimen of aspirin pretreatment, bivalirudin during the procedure and clopidogrel (600 mg) immediately after percutaneous coronary intervention (PCI) was associated with platelet activation during and shortly after (1 and 2 h) PCI, we characterized platelet function in 10 patients with the use of flow cytometry in the absence of agonist and in response to thrombin (10 nM), ADP (1 microM), the collagen-mimetic convulxin (5 ng/ml), and platelet activating factor (10 nM). Activation of platelets in peripheral blood was rare (<0.5% of platelets) before, during and after PCI. Platelet reactivity in response to each of the agonists was lower after the PCI compared with that in blood taken before the PCI. Accordingly, platelet activation and platelet reactivity were not increased after elective PCI when patients were treated during the procedure with aspirin and bivalirudin and immediately after the procedure with a 600 mg loading dose of clopidogrel.
Schneider
David J
DJ
Cardiovascular Research Institute, Department of Medicine, University of Vermont, Burlington, VT 05446, USA. david.schneider@uvm.edu
Sobel
Burton E
BE
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000787:Angina Pectoris / Q000097:blood*; D000925:Anticoagulants / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage; D006328:Cardiac Catheterization; D000077144:Clopidogrel; D017558:Elective Surgical Procedures; D006490:Hemostatics / Q000494:pharmacology; D006629:Hirudins / Q000008:administration & dosage*; D006801:Humans; D010446:Peptide Fragments / Q000008:administration & dosage*; D015539:Platelet Activation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011184:Postoperative Period; D011994:Recombinant Proteins / Q000008:administration & dosage; D013917:Thrombin / Q000494:pharmacology; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D013997:Time Factors
D000925:Anticoagulants; D006490:Hemostatics; D006629:Hirudins; D010446:Peptide Fragments; D010975:Platelet Aggregation Inhibitors; D011994:Recombinant Proteins; D000244:Adenosine Diphosphate; D000077144:Clopidogrel; D013917:Thrombin; D013988:Ticlopidine; D001241:Aspirin; C074619:bivalirudin