[Vascular calcification and anti-aging].
Vascular calcification encountered in atherosclerotic lesions is a common consequence of aging. We suggested that apoptosis plays an important role in vascular smooth muscle cells (VSMC) calcification which is dependent on downregulation of the growth arrest-specific gene 6 (Gas6) -mediated survival pathway. Recently, we demonstrated that adiponectin antagonizes the stimulatory effect of TNF-alpha on vascular calcification by restoration of the AMP-activated protein kinase (AMPK) -dependent Gas6-mediated survival pathway. These results provide evidences of the effect of metabolic syndrome on vascular diseases including calcification.
Son
Bo-Kyung
BK
University of Tokyo, Graduate School of Medicine, Department of Geriatric Medicine.
Akishita
Masahiro
M
D055372:AMP-Activated Protein Kinases; D052242:Adiponectin / Q000502:physiology; D000375:Aging / Q000473:pathology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D050197:Atherosclerosis / Q000473:pathology; D001808:Blood Vessels / Q000473:pathology*; D002114:Calcinosis; D015536:Down-Regulation; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D024821:Metabolic Syndrome / Q000473:pathology; D009097:Multienzyme Complexes / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D000099255:Growth Arrest-Specific Protein 6
D055372:AMP-Activated Protein Kinases; D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins; D009097:Multienzyme Complexes; D017346:Protein Serine-Threonine Kinases; D014409:Tumor Necrosis Factor-alpha; D000099255:Growth Arrest-Specific Protein 6