Targeted ablation of the vitamin D 1alpha-hydroxylase gene: getting to the heart of the matter.
Targeted gene ablation technology has uncovered biological mechanisms that have led to important therapeutics in humans. In a study by Zhou et al., ablation of the 1alpha-hydroxylase gene led to hypertension, cardiac hypertrophy, and systolic dysfunction, and this cardiac phenotype was rescued with exogenous 1,25-dihydroxyvitamin D administration.
Thadhani
Ravi
R
Renal Unit and the Center for D-Receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. thadhani.ravi@mgh.harvard.edu
D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000235:genetics; D000818:Animals; D006332:Cardiomegaly / Q000235:genetics / Q000503:physiopathology* / Q000517:prevention & control*; D018390:Gene Targeting; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology* / Q000517:prevention & control*; D051379:Mice; D018345:Mice, Knockout; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism
D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase