Soft tissue sarcoma in the setting of chronic cutaneous graft versus host disease after allogenic bone marrow transplantation.
Second primary cancers are approximately 2.1-2.8 times more common in survivors of bone marrow transplant than in the age-matched general population. We describe a patient who developed high-grade sarcoma in two disparate sites that were clinically involved by chronic cutaneous graft versus host disease (GVHD). This occurred 3.5 years after bone marrow transplant for acute myelogenous leukemia (AML). This suggests that malignant sarcomas may develop in the setting of chronic GVHD, and close surveillance of GVHD-related nodules is warranted.
Bylund
Kevin C
KC
University of Rochester School of Medicine, Rochester, New York 14642, USA. kevin bylund@urmc.rochester.edu
Giampoli
Ellen
E
Singh
Deepinder
D
Doerr
Timothy
T
Sahasrabudhe
Deepak
D
Liesveld
Jane
J
Constine
Louis S
LS
D000328:Adult; D044963:Biopsy, Fine-Needle; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D017024:Chemotherapy, Adjuvant; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000150:complications* / Q000209:etiology / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000601:surgery*; D008297:Male; D020360:Neoadjuvant Therapy; D016609:Neoplasms, Second Primary; D018714:Radiotherapy, Adjuvant; D012509:Sarcoma / Q000209:etiology* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D012871:Skin Diseases / Q000150:complications* / Q000209:etiology / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous; D016896:Treatment Outcome