title: Effect of sublingual administration of interferon-alpha on the immune response to influenza vaccination in institutionalized elderly individuals.
abstract: A randomized double-blind placebo-controlled study was conducted to determine the effect of sublingual administration of IFNalpha on the immune response to influenza vaccination in elderly institutionalized individuals. Sublingual administration of 10 million IU of IFNalpha immediately prior to vaccination, reduced the geometric mean haemagglutination inhibitory (HAI) and IgG2 circulating antibody titers, and the secretory IgA (sIgA) response in saliva, to the New York strain of influenza A virus, 21 days post-vaccination, without detectable drug-related local or systemic toxicity. IFN treatment did not inhibit the immune response to the other components of the vaccine; the New Caledonia strain of influenza A virus, or the Jiangsu strain of influenza B virus. At the dose tested sublingual administration of IFNalpha reduces the immune response to influenza vaccination in elderly institutionalized individuals.
authors.affiliation: Université Paris Descartes, Faculté de Médecine, Paris, France.
authors.forename: Odile
authors.initials: O
authors.lastname: Launay
authors.forename: Sophie
authors.initials: S
authors.lastname: Grabar
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bloch
authors.forename: Corinne
authors.initials: C
authors.lastname: Desaint
authors.forename: David
authors.initials: D
authors.lastname: Jegou
authors.forename: Christophe
authors.initials: C
authors.lastname: Lallemand
authors.forename: Robert
authors.initials: R
authors.lastname: Erickson
authors.forename: Pierre
authors.initials: P
authors.lastname: Lebon
authors.forename: Michael G
authors.initials: MG
authors.lastname: Tovey
mesh_terms: D000286:Administration, Sublingual; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D018819:Dipeptidyl Peptidase 4 / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007074:Immunoglobulin G / Q000097:blood; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000276:immunology* / Q000633:toxicity; D017730:Ki-1 Antigen / Q000097:blood; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007252:Influenza Vaccines; D016898:Interferon-alpha; D017730:Ki-1 Antigen; D018819:Dipeptidyl Peptidase 4