title: Special safety considerations in preparation of technetium Tc-99m DTPA for cerebrospinal fluid-related imaging procedures.
abstract: OBJECTIVE
  To review special safety considerations in the preparation of technetium 99m (Tc-99m) diethylenetriaminepentaacetic acid (DTPA; generic name, pentetate) for cerebrospinal fluid (CSF)-related imaging procedures.
  
  
  METHODS
  Review of practices and results at one institution supplemented with findings and recommendations from the literature. Literature searches were conducted via Medline/PubMed using the following terms: Tc-99m DTPA/pentetate, CSF, cisternography, intrathecal, and adverse reactions. The author's own files were also searched for articles (e.g., in newsletters) not indexed by Medline/PubMed.
  
  
  METHODS
  Articles considered appropriate for review included all human research studies, reviews, case reports, abstracts, and letters published in English on Tc-99m DTPA use in CSF-related imaging procedures, especially with regard to safety or adverse reactions.
  
  
  METHODS
  All information related to safety precautions and adverse reactions associated with Tc-99m DTPA injected intrathecally or otherwise used for CSF-related imaging procedures were considered.
  
  
  RESULTS
  18 years' experience in one institution was reviewed with the added perspective of literature findings and recommendations.
  
  
  CONCLUSIONS
  With proper attention to safety considerations, Tc-99m DTPA can be safely used in CSF-related imaging procedures.
authors.affiliation: College of Pharmacy, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA. james-ponto@uiowa.edu
authors.forename: James A
authors.initials: JA
authors.lastname: Ponto
mesh_terms: D002555:Cerebrospinal Fluid / Q000000981:diagnostic imaging*; D004339:Drug Compounding / Q000379:methods; D004340:Drug Contamination / Q000517:prevention & control; D004731:Endotoxins; D006801:Humans; D007278:Injections, Spinal; D011859:Radiography; D019275:Radiopharmaceuticals / Q000009:adverse effects* / Q000592:standards; D016284:Technetium Tc 99m Pentetate / Q000009:adverse effects* / Q000592:standards
chemical_list: D004731:Endotoxins; D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate