Low urinary 6-sulphatoxymelatonin concentrations in acute migraine.
Substantial evidence points to melatonin as playing a role in the regulation of circadian rhythms, sleep, and headache disorders. The objective of the study was to assess 6-sulphatoxymelatonin (aMT6s) levels in a large consecutive series of patients with migraine, comparing with controls. A total of 220 subjects were evaluated-146 had migraine and 74 were control subjects. Urinary samples were collected into the same plastic container since 8:00 p.m. to 8:00 a.m. of the next day (12-h period) and aMT6s was measured with quantitative ELISA technique. Among patients with migraine, 53% presented pain on the day of the urine samples collection. Their urinary aMT6s concentration was significantly lower than in the urine of patients without pain [14.0 +/- 7.3 vs. 49.4 +/- 19.0; t(143) = -15.1; 95% CI = -40.0 to -30.8; P < 0.001]. There was no significant difference in the aMT6s concentration of patients with migraine without pain on the day of their urine samples collection and controls [49.4 +/- 19.0 vs. 42.5 +/- 27.9; t(140) = 1.7; 95% CI = -1.2 to 14.8; P = 0.094]. To our knowledge, this is the first study to demonstrate reduction in melatonin levels during attacks in episodic and chronic migraine.
Masruha
Marcelo Rodrigues
MR
Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo, Brazil.
de Souza Vieira
Domingos Sávio
DS
Minett
Thais Soares Cianciarullo
TS
Cipolla-Neto
José
J
Zukerman
Eliova
E
Vilanova
Luiz Celso Pereira
LC
Peres
Mario Fernando Prieto
MF
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives* / Q000652:urine; D008875:Middle Aged; D008881:Migraine Disorders / Q000145:classification / Q000652:urine*; D016017:Odds Ratio; D012189:Retrospective Studies
C054513:6-sulfatoxymelatonin; D008550:Melatonin