title: Initial clinical results for breath-hold CT-based processing of respiratory-gated PET acquisitions.
abstract: OBJECTIVE
  Respiratory motion causes uptake in positron emission tomography (PET) images of chest structures to spread out and misregister with the CT images. This misregistration can alter the attenuation correction and thus the quantisation of PET images. In this paper, we present the first clinical results for a respiratory-gated PET (RG-PET) processing method based on a single breath-hold CT (BH-CT) acquisition, which seeks to improve diagnostic accuracy via better PET-to-CT co-registration. We refer to this method as "CT-based" RG-PET processing.
  
  
  METHODS
  Thirteen lesions were studied. Patients underwent a standard clinical PET protocol and then the CT-based protocol, which consists of a 10-min List Mode RG-PET acquisition, followed by a shallow end-expiration BH-CT. The respective performances of the CT-based and clinical PET methods were evaluated by comparing the distances between the lesions' centroids on PET and CT images. SUV(MAX) and volume variations were also investigated.
  
  
  RESULTS
  The CT-based method showed significantly lower (p = 0.027) centroid distances (mean change relative to the clinical method = -49%; range = -100% to 0%). This led to higher SUV(MAX) (mean change = +33%; range = -4% to 69%). Lesion volumes were significantly lower (p = 0.022) in CT-based PET volumes (mean change = -39%: range = -74% to -1%) compared with clinical ones.
  
  
  CONCLUSIONS
  A CT-based RG-PET processing method can be implemented in clinical practice with a small increase in radiation exposure. It improves PET-CT co-registration of lung lesions and should lead to more accurate attenuation correction and thus SUV measurement.
authors.affiliation: Nuclear Medicine Department, Amiens University Hospital, Amiens, France.
authors.forename: Loïc
authors.initials: L
authors.lastname: Fin
authors.forename: Joël
authors.initials: J
authors.lastname: Daouk
authors.forename: Julie
authors.initials: J
authors.lastname: Morvan
authors.forename: Pascal
authors.initials: P
authors.lastname: Bailly
authors.forename: Isabelle
authors.initials: I
authors.lastname: El Esper
authors.forename: Lazhar
authors.initials: L
authors.lastname: Saidi
authors.forename: Marc-Etienne
authors.initials: ME
authors.lastname: Meyer
mesh_terms: D000368:Aged; D016477:Artifacts; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008168:Lung / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D012119:Respiration; D014057:Tomography, X-Ray Computed