title: Effect of domperidone on QT interval in neonates.
abstract: OBJECTIVE
  To determine whether oral domperidone is associated with QT interval prolongation and ventricular arrhythmia and to identify factors that can influence these effects.
  
  
  METHODS
  An electrocardiogram was performed before and after oral administration of domperidone in 31 neonates or infants classified into 3 groups according to gestational age.
  
  
  RESULTS
  Oral domperidone is associated with QTc prolongation except in infants with a gestational age less than 32 weeks of amenorrhea (P < .005). Mean QTc prolongation was 14 msec. On univariate analysis, oral domperidone-induced QTc prolongation was correlated with gestational age, birth weight, and elevated serum potassium. On multivariate analysis, after adjustment for gestational age, serum potassium was the only factor independently associated with interval QT prolongation during treatment. No ventricular arrhythmias were observed.
  
  
  CONCLUSIONS
  This study shows a significant association between oral domperidone therapy and QTc prolongation. Two risk factors were identified: advanced gestational age and serum potassium at the upper limit of normal. It is recommended that measurement of the QT interval be done before and after oral domperidone therapy.
authors.affiliation: Department of Pediatrics, School Hospital of Amiens, Amiens, France. djeddi.djamal-dine@chu-amiens.fr
authors.forename: Djamal
authors.initials: D
authors.lastname: Djeddi
authors.forename: Guy
authors.initials: G
authors.lastname: Kongolo
authors.forename: Charlotte
authors.initials: C
authors.lastname: Lefaix
authors.forename: Julie
authors.initials: J
authors.lastname: Mounard
authors.forename: André
authors.initials: A
authors.lastname: Léké
mesh_terms: D000284:Administration, Oral; D001145:Arrhythmias, Cardiac / Q000175:diagnosis; D004294:Domperidone / Q000009:adverse effects* / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008133:Long QT Syndrome / Q000188:drug therapy* / Q000209:etiology*; D009200:Myocardial Contraction / Q000187:drug effects; D011188:Potassium / Q000097:blood; D012306:Risk; D012307:Risk Factors
chemical_list: D018492:Dopamine Antagonists; D004294:Domperidone; D011188:Potassium