General and efficient copper-catalyzed amidation of saturated C-H bonds using N-halosuccinimides as the oxidants.
We have developed a general and efficient method for copper-catalyzed amidation of saturated C-H bonds under mild conditions, and the used substrates include benzylic reagents, the N, N-dimethylaniline derivatives, the free carboxamides, and sulfonamides. The protocol uses inexpensive and readily available CuBr/ N-halosuccinimide (NBS or NCS) as the catalyst/oxidant, so it provides practical applications for synthesis of various amides via C-H activation.
Liu
Xiaowei
X
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Zhang
Yongming
Y
Wang
Long
L
Fu
Hua
H
Jiang
Yuyang
Y
Zhao
Yufen
Y
D000577:Amides / Q000138:chemical synthesis*; D001593:Benzyl Compounds / Q000737:chemistry; D001974:Bromosuccinimide / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry*; D013388:Succinimides / Q000737:chemistry*
D000577:Amides; D001593:Benzyl Compounds; D016877:Oxidants; D013388:Succinimides; C015752:N-chlorosuccinimide; D003300:Copper; D001974:Bromosuccinimide