title: Autophagic control of listeria through intracellular innate immune recognition in drosophila.
abstract: Autophagy, an evolutionally conserved homeostatic process for catabolizing cytoplasmic components, has been linked to the elimination of intracellular pathogens during mammalian innate immune responses. However, the mechanisms underlying cytoplasmic infection-induced autophagy and the function of autophagy in host survival after infection with intracellular pathogens remain unknown. Here we report that in drosophila, recognition of diaminopimelic acid-type peptidoglycan by the pattern-recognition receptor PGRP-LE was crucial for the induction of autophagy and that autophagy prevented the intracellular growth of Listeria monocytogenes and promoted host survival after this infection. Autophagy induction occurred independently of the Toll and IMD innate signaling pathways. Our findings define a pathway leading from the intracellular pattern-recognition receptors to the induction of autophagy to host defense.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
authors.forename: Tamaki
authors.initials: T
authors.lastname: Yano
authors.forename: Shizuka
authors.initials: S
authors.lastname: Mita
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ohmori
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Oshima
authors.forename: Yukari
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Ryu
authors.initials: R
authors.lastname: Ueda
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Takada
authors.forename: William E
authors.initials: WE
authors.lastname: Goldman
authors.forename: Koichi
authors.initials: K
authors.lastname: Fukase
authors.forename: Neal
authors.initials: N
authors.lastname: Silverman
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Yoshimori
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Kurata
mesh_terms: D000818:Animals; D001343:Autophagy; D003960:Diaminopimelic Acid; D004330:Drosophila / Q000235:genetics / Q000254:growth & development / Q000276:immunology* / Q000378:metabolism*; D007113:Immunity, Innate / Q000276:immunology*; D008087:Listeria / Q000166:cytology / Q000276:immunology*; D010457:Peptidoglycan / Q000276:immunology / Q000378:metabolism*; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D010457:Peptidoglycan; D051193:Toll-Like Receptors; D003960:Diaminopimelic Acid