Benign transient hyperphosphatasemia associated with Epstein-Barr virus enteritis in a pediatric liver transplant patient: a case report.
Transient hyperphosphatasemia was found in a 3-year-old male liver transplant recipient. The condition was associated with diarrheal disease due to the Epstein-Barr virus (EBV). Immunosuppression was tapered and valganciclovir prescribed for 3 months, after which the diarrhea resolved and the EBV polymerase chain reaction assays became negative. After 6 months, alkaline phosphatase levels normalized. Isolated elevation of alkaline phosphatase in conjunction with enteric infection is a rare condition. No further diagnostic or therapeutic interventions except treatment of the underlying infection are needed, as this has been shown to be a benign, transient condition.
Hranjec
T
T
Department of Surgery, Division of Transplantation, University of Virginia Health Services, Charlottesville, Virginia, USA.
Bonatti
H
H
Roman
A L
AL
Sifri
C
C
Borowitz
S M
SM
Barnes
B H
BH
Flohr
T R
TR
Pruett
T L
TL
Sawyer
R G
RG
Schmitt
T M
TM
D000328:Adult; D002675:Child, Preschool; D002779:Cholestasis / Q000601:surgery*; D004751:Enteritis / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005190:Family; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016031:Liver Transplantation / Q000276:immunology; D019520:Living Donors; D008297:Male; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D010760:Phosphorus Metabolism Disorders / Q000175:diagnosis* / Q000201:enzymology / Q000209:etiology; D011183:Postoperative Complications / Q000175:diagnosis*; D016559:Tacrolimus / Q000627:therapeutic use; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D010744:Phosphoric Monoester Hydrolases; D016559:Tacrolimus