[Role of kidney in calcium homeostasis and premature aging].
The kidney plays a critical role in the calcium (Ca) homeostasis. With advancing age, the kidney function, including glomerular filtration rate and tubular electrolyte reabsorption, is deteriorating without any kidney disease. Disturbed Ca metabolism may be associated with premature aging process, in which various cellular function is impaired by intracellular Ca burden due to increased Ca efflux from bone. Fibroblast growth factor (FGF) 23, a novel phosphate (P) -regulating factor, is involved in disorders of mineral bone metabolism. Recent studies suggest that FGF23 plays a certain role in premature aging process through altered P and vitamin D metabolism.
Ogata
Hiroaki
H
Showa University Northern Yokohama Hospital, Department of Internal Medicine.
Wada
Yukihiro
Y
Akizawa
Tadao
T
D000375:Aging / Q000502:physiology*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D007668:Kidney / Q000502:physiology*; D010758:Phosphorus / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism
C000717427:FGF23 protein, human; D014807:Vitamin D; D010758:Phosphorus; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002118:Calcium