title: Beneficial effect of chungkukjang on regulating blood glucose and pancreatic beta-cell functions in C75BL/KsJ-db/db mice.
abstract: The current study investigated the antidiabetic effect of chungkukjang, a widely used traditional Korean soybean fermentation food, in a type 2 diabetic animal model, C57BL/KsJ-db/db mice. After a 2-week acclimation period, the db/db mice (male, 5 weeks old) were divided into three groups: diabetic control (AIN-76 diet), chungkukjang (5 g/100 g of diet), and rosiglitazone (0.005 g/100 g of diet). The supplementation of chungkukjang induced a significant reduction of blood glucose and glycosylated hemoglobin level, and it improved insulin tolerance compared to the diabetic control group. Plasma and pancreatic insulin levels of the chungkukjang-supplemented group were significantly higher than those of the diabetic control mice, and the plasma glucagon level was also significantly different. The supplementation of chungkukjang and rosiglitazone significantly elevated hepatic glucokinase activity with a simultaneous reduction of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activity in the db/db mice compared to the diabetic control mice. In addition, the chungkukjang-supplemented group had an increased hepatic glycogen content compared to the diabetic control and rosiglitazone-supplemented groups. Consequently, these results suggest that chungkukjang may be beneficial in improving insulin resistance and hyperglycemia in type 2 diabetic animals that are partly medicated by the regulation of hepatic glucose enzymes and insulin sensitivity in peripheral tissues.
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Republic of Korea.
authors.forename: Dong-Ju
authors.initials: DJ
authors.lastname: Kim
authors.forename: Yong-Jin
authors.initials: YJ
authors.lastname: Jeong
authors.forename: Joong-Ho
authors.initials: JH
authors.lastname: Kwon
authors.forename: Kwang-Deog
authors.initials: KD
authors.lastname: Moon
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Seon-Min
authors.initials: SM
authors.lastname: Jeon
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Yong Bok
authors.initials: YB
authors.lastname: Park
authors.forename: Myung-Sook
authors.initials: MS
authors.lastname: Choi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology*; D005285:Fermentation; D005934:Glucagon / Q000032:analysis / Q000097:blood; D005941:Glucokinase / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000032:analysis; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000032:analysis / Q000097:blood; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000502:physiology*; D007529:Isoflavones / Q000008:administration & dosage*; D020738:Leptin / Q000097:blood; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010179:Pancreas / Q000737:chemistry; D000077154:Rosiglitazone; D030262:Soybean Proteins / Q000008:administration & dosage*; D013025:Glycine max / Q000737:chemistry; D045162:Thiazolidinediones / Q000008:administration & dosage
chemical_list: D001786:Blood Glucose; D005934:Glucagon; D005941:Glucokinase; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D007529:Isoflavones; D020738:Leptin; D000077154:Rosiglitazone; D030262:Soybean Proteins; D045162:Thiazolidinediones; C525760:chungkookjang