Leishmania (Leishmania) amazonensis: experimental cutaneous leishmaniasis associated with systemic amyloidosis in mice.
We infected Swiss and C57BL/6 female mice in the left hind footpad with 10(4)Leishmania (L.) amazonensis promastigotes in stationary phase. The macroscopic examination showed a nodular non-ulcerated lesion at the site of inoculation and hepatic and spleenic enlargement. Histopathologically, the primary lesion showed an extensive liquefactive necrosis and inflammatory infiltrate, mainly consisting of macrophages filled with amastigotes, and rare lymphocytes. The inflammatory reaction in liver, spleen and kidney showed amyloid deposits. Additionally, C57BL/6 had accentuated amyloidosis in both ovarian cortical and medullar region and inflammatory infiltrates in the pancreas and adrenal gland.
Carvalho
Luiz Otávio Pereira
LO
Laboratório de Imunomodulação e Protozoologia do Instituto Oswaldo Cruz/FIOCRUZ, Pavilhão Carlos Chagas, 3 degrees andar, Av. Brasil, 4365, Manguinhos, CEP 20045-900, Rio de Janeiro, Brazil.
Calabrese
Kátia da Silva
Kda S
da Costa
Sylvio Celso Gonçalves
SC
Mendes
Verônica Gonçalves
VG
da Silva
Ana Patrícia de Carvalho
AP
Barros
Ana Caroline Ericeira
AC
Melo
Solange de Araújo
Sde A
Abreu-Silva
Ana Lucia
AL
D000311:Adrenal Glands / Q000473:pathology; D000686:Amyloidosis / Q000150:complications* / Q000469:parasitology / Q000473:pathology; D000818:Animals; D005260:Female; D007515:Islets of Langerhans / Q000473:pathology; D007668:Kidney / Q000473:pathology; D007894:Leishmania mexicana; D016773:Leishmaniasis, Cutaneous / Q000150:complications*; D008099:Liver / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D010053:Ovary / Q000473:pathology; D013154:Spleen / Q000473:pathology