title: Corneal pathology in microphthalmia with linear skin defects syndrome.
abstract: To describe the histopathology of the cornea in microphthalmia with linear streaks (MLS) syndrome.
  
  
  
  Two patients with MLS syndrome underwent penetrating keratoplasty. This study describes the histopathology and investigates immunophenotype of the corneal extracellular matrix by using keratan sulfate and collagen type III antibodies.
  
  
  
  Clinical examination revealed bilateral sclerocornea and characteristic skin changes. By light microscopy, central corneal stroma in both patients showed vascularization and irregular thick collagen lamellae typical of sclerocornea. In addition, corneal thinning, anterior synechiae, and the absence of the Descemet membrane were noted, which was suggestive of Peters anomaly. Diffuse and intense anti-keratan sulfate staining and minimal anti-collagen type III stromal staining were seen in both corneal buttons.
  
  
  
  The cornea in MLS may clinically resemble sclerocornea. Histologic features resemble those previously described in sclerocornea and also seen in anterior segment dysgeneses. Keratan sulfate and collagen type III labeling suggests that the corneal extracellular matrix resembled cornea and not sclera.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Kapur
authors.forename: Elmer Y
authors.initials: EY
authors.lastname: Tu
authors.forename: Sami
authors.initials: S
authors.lastname: Toyran
authors.forename: Parthiv
authors.initials: P
authors.lastname: Shah
authors.forename: Sumalee
authors.initials: S
authors.lastname: Vangveeravong
authors.forename: William C
authors.initials: WC
authors.lastname: Lloyd
authors.forename: Deepak P
authors.initials: DP
authors.lastname: Edward
mesh_terms: D024061:Collagen Type III / Q000378:metabolism; D003315:Cornea / Q000002:abnormalities* / Q000378:metabolism / Q000473:pathology*; D003318:Corneal Opacity / Q000150:complications* / Q000235:genetics / Q000601:surgery; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D007632:Keratan Sulfate / Q000378:metabolism; D015948:Keratoplasty, Penetrating; D008297:Male; D008850:Microphthalmos / Q000150:complications* / Q000235:genetics; D012590:Sclera / Q000002:abnormalities* / Q000378:metabolism; D012868:Skin Abnormalities / Q000150:complications* / Q000235:genetics; D013577:Syndrome
chemical_list: D024061:Collagen Type III; D007632:Keratan Sulfate