Phagocytosis: dynamin's dual role in phagosome biogenesis.
Dynamins have a well-established role in the fission of vesicles at sites of endocytosis. In phagocytosis, however, a role for certain dynamin isoforms has been reported in the full extension of pseudopods during phagosome formation, not in fission of the phagocytic vacuole. Recent studies in Caenorhabditis elegans have now uncovered a new function of dynamin in phagosome maturation.
Huynh
Kassidy K
KK
Cell Biology Programme, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.
Grinstein
Sergio
S
D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism*; D034281:Dynamins / Q000378:metabolism*; D010587:Phagocytosis; D010588:Phagosomes / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D020696:rab5 GTP-Binding Proteins / Q000378:metabolism
D019869:Phosphatidylinositol 3-Kinases; D020696:rab5 GTP-Binding Proteins; D034281:Dynamins