Serum urate, metabolic syndrome, and cardiovascular risk factors. A population-based study.
We studied the associations between serum urate levels (determined in 503 subjects from a population of 1,344 subjects living in northern Madrid) and both the metabolic syndrome (MS) (defined by the Adult Treatment Panel III criteria) and C-reactive protein (CRP, determined in 382 subjects). MS was diagnosed in 25% (95%CI, 21-28%) and was associated with hyperuricemia (p<0.001). There was a graded increase in serum urate levels with increasing number of MS components. Urate concentrations significantly correlated with waist circumference (r=0,455, p<0.01). Serum urate was not independently associated with CRP levels. This study shows that serum urate levels are associated with the presence of MS and each of its features.
Puig
J G
JG
Divisions of Internal Medicine, La Paz University Hospital, Madrid, Spain. jgpuig@terra.es
Martínez
M A
MA
Mora
M
M
Fraile
J M
JM
Montoya
F
F
Torres
R J
RJ
D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology* / Q000378:metabolism; D008875:Middle Aged; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid; D002097:C-Reactive Protein