Benefit of adding pioglitazone to successful statin therapy in nondiabetic patients with coronary artery disease.
BACKGROUND
Pioglitazone added to successful statin therapy may be beneficial for coronary artery disease (CAD) patients without diabetes mellitus.


RESULTS
Fourteen individuals optimally treated with statin for >6 months were randomized to a pioglitazone or control group. Pioglitazone significantly improved insulin resistance, reduced high-sensitivity C-reactive protein, increased high-molecular-weight adiponectin and high-density lipoprotein cholesterol levels. Ultrasound echogenicity of carotid atheroma assessed by integrated backscatter was significantly increased by pioglitazone and correlated with adiponectin levels.


CONCLUSIONS
Adding pioglitazone to successful statin therapy may be an effective therapeutic strategy for patients with CAD.
Sugamura
Koichi
K
Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University, Kumamoto, Japan.
Sugiyama
Seigo
S
Matsuzawa
Yasushi
Y
Nozaki
Toshimitsu
T
Horibata
Yoko
Y
Ogawa
Hisao
H
D052242:Adiponectin / Q000097:blood / Q000737:chemistry; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy; D008076:Cholesterol, HDL / Q000097:blood; D003324:Coronary Artery Disease / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D000077205:Pioglitazone; D045162:Thiazolidinediones / Q000008:administration & dosage*; D016896:Treatment Outcome; D014463:Ultrasonography
C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D002097:C-Reactive Protein; D000077205:Pioglitazone