title: Delayed-onset dystonia in patients with antecedents of perinatal asphyxia.
abstract: We report 27 cases of delayed-onset dystonia in patients with antecendents of perinatal asphyxia after excluding other possible causes of dystonia. The patients were 16 males and 11 females (mean +/- SD age at onset of dystonia = 13.0 +/- 9.4 yr). Adverse obstetric and/or perinatal events were presented by 20 patients, and other neurological symptoms or signs were present prior to dystonia in 15 patients. The pattern of dystonia was: generalized (eight cases), segmental (six), multifocal (three), hemidystonia (two), and focal (eight). Cranial CT or MRI were normal in 21 cases, and showed brain hemiatrophy in three cases, and periventricular demyelination, subcortical atrophy and increased ventricular size in one case each. The possible cause-effect relationship is discussed.
authors.affiliation: Universitario "Principe de Asturias", Alcalá de Henares-Madrid, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
authors.forename: J
authors.initials: J
authors.lastname: Burguera
authors.forename: M J
authors.initials: MJ
authors.lastname: Catalán
authors.forename: A
authors.initials: A
authors.lastname: Vázquez
authors.forename: J
authors.initials: J
authors.lastname: Vaamonde
authors.forename: L
authors.initials: L
authors.lastname: Vela-Desojo
authors.forename: P
authors.initials: P
authors.lastname: Martínez-Martín
authors.forename: J
authors.initials: J
authors.lastname: Balseiro
authors.forename: M
authors.initials: M
authors.lastname: Pondal-Sordo
authors.forename: J
authors.initials: J
authors.lastname: Domingo
authors.forename: P J
authors.initials: PJ
authors.lastname: García-Ruiz
authors.forename: A
authors.initials: A
authors.lastname: Muñoz-Vázquez
authors.forename: J
authors.initials: J
authors.lastname: Molina
authors.forename: M A
authors.initials: MA
authors.lastname: Ceballos-Hernánsont
authors.forename: J
authors.initials: J
authors.lastname: Arcaya
authors.forename: J
authors.initials: J
authors.lastname: Duarte