Genomic analysis in nephrology--towards systems biology and systematic medicine?
With the advent of transcriptome profiling techniques, an enormous amount of data has been generated in the field of molecular nephrology. We will review analysis tools and challenges for genomic approaches and present their application in gene-expression studies on kidney biopsies. The findings in this rapidly evolving field may ultimately complement histopathological analysis, the current diagnostic and prognostic gold standard. Altogether, genomics may bring nephrology one-step closer to a systematic understanding of biological processes involved in renal disease.
Neusser
Matthias A
MA
Nephrologisches Zentrum, Medizinische Poliklinik, University of Munich, Munich, Germany.
Lindenmeyer
Maja T
MT
Kretzler
Matthias
M
Cohen
Clemens D
CD
D001706:Biopsy; D019295:Computational Biology; D015870:Gene Expression; D020869:Gene Expression Profiling; D023281:Genomics; D006801:Humans; D007668:Kidney / Q000033:anatomy & histology / Q000502:physiology; D007674:Kidney Diseases / Q000235:genetics* / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects; D009398:Nephrology; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017211:Treatment Failure
D012333:RNA, Messenger