Nutrition and cancer: essential elements for a roadmap.
Personalizing nutrition for cancer prevention and therapy will require a comprehensive understanding of "genotypes/phenotypes" in order to identify, evaluate, and prioritize appropriate points for dietary intervention. This nutritional preemption roadmap must begin with accurately assessing intakes/exposures of which bioactive food component(s) is needed to bring about a desired response in critical cellular processes (carcinogen metabolism, DNA repair, cell proliferation, apoptosis, inflammation, immunity, differentiation, angiogenesis, hormonal regulation and cellular energetic) within an individual. Understanding this "individuality" through a better understanding of the "omics" is fundamental to arriving at the correct destination and thus interpreting biological variables which establish the magnitude or direction of a response to bioactive food components.
Milner
J A
JA
Nutritional Sciences Research Group, Division Cancer Prevention, NCI/NIH/HHS, 6130 Executive Boulevard, Executive Plaza North, Suite 3164, Rockville, MD 20852, USA. milnerj@mail.nih.gov
D000818:Animals; D017209:Apoptosis; D019175:DNA Methylation; D019587:Dietary Supplements; D044127:Epigenesis, Genetic; D023281:Genomics; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000235:genetics / Q000517:prevention & control* / Q000628:therapy; D009747:Nutritional Physiological Phenomena; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics
D018167:Receptors, Calcitriol