title: Revisiting the sponge sources, stereostructure, and biological activity of cyclocinamide a.
abstract: The dramatic biogeographical variations in the secondary metabolites from Psammocinia aff. bulbosa have complicated our efforts to reisolate the two most cytotoxic of its metabolites, (+)-psymberin and (+)-cyclocinamide A. Reported now are the results of a new study that demonstrates our ability to repeatedly isolate these two compounds through targeted collection efforts. Additional study of the new sample of (+)-cyclocinamide A has enabled finalizing its biological activity and absolute stereochemistry as 4S, 7S, 11S, 14S.
authors.affiliation: Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California Santa Cruz, Santa Cruz, California 95064, USA.
authors.forename: Brent K
authors.initials: BK
authors.lastname: Rubio
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Robinson
authors.forename: Claudia E
authors.initials: CE
authors.lastname: Avalos
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Valeriote
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: de Voogd
authors.forename: Phillip
authors.initials: P
authors.lastname: Crews
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D010456:Peptides, Cyclic; C533363:cyclocinamide A