title: Anti-RO anti-LA anti-RNP antibodies and eletrocardiogram's PR interval in adult patients with systemic lupus erythematosus.
abstract: BACKGROUND
  Children born from mothers with anti-Ro La or RNP autoantibodies may develop neonatal lupus. One of the manifestations of neonatal lupus is congenital atrio ventricular block.
  
  
  OBJECTIVE
  To study EKG PR interval in adult systemic lupus erythematosus (SLE) patients with anti-Ro anti-La and anti-RNP autoantibodies.
  
  
  METHODS
  PR intervals and the presence of anti-Ro La and RNP antibodies were studied in 61 SLE patients and compared with 61 controls.
  
  
  RESULTS
  36.6% of SLE patients were anti-Ro positive 20% were anti-La and 22.9% were anti-RNP positive. All studied PR intervals were within normal limits (upper limit of 0.2 sec). We did not find any association between PR interval length and the presence of anti-Ro (p=0.54) anti-La (p=0.45) or anti-RNP autoantibodies (p=0.36).
  
  
  CONCLUSIONS
  The presence of anti-Ro La and RNP autoantibodies does not influence PR interval in adult SLE patients.
authors.affiliation: Servico de Reumatologia do Hospital Universitario Evangelico de Curitiba-PR Brasil.
authors.forename: Militino
authors.initials: M
authors.lastname: Costa
authors.forename: Marilia Barreto
authors.initials: MB
authors.lastname: Gameiro Silva
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Silva
authors.forename: Thelma L
authors.initials: TL
authors.lastname: Skare
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D055517:snRNP Core Proteins
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D001324:Autoantigens; C035356:SS-A antibodies; C035357:SS-B antibodies; D055517:snRNP Core Proteins