title: Low-cost, multimodal, portable screening system for early detection of oral cancer.
abstract: Oral cancer is an important global health problem. There is an urgent need for improved methods to detect oral cancer and its precursors, because early detection is the best way to reduce oral cancer mortality and morbidity. In this work, we describe simple modifications to a surgical headlight system that enables direct visualization and digital image acquisition from oral tissue in multiple imaging modalities including fluorescence, white-light reflectance, and orthogonal polarization reflectance. Images obtained with the system in-vivo demonstrate that it is an attractive technology to explore for oral cancer screening in low-resource environments where clinical expertise is often unavailable.
authors.affiliation: Rice University, Department of Bioengineering, 6100 Main Street, Houston, Texas 77005, USA.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Rahman
authors.forename: Pankaj
authors.initials: P
authors.lastname: Chaturvedi
authors.forename: Ann M
authors.initials: AM
authors.lastname: Gillenwater
authors.forename: Rebecca
authors.initials: R
authors.lastname: Richards-Kortum
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation*; D008029:Lighting / Q000295:instrumentation*; D008403:Mass Screening / Q000191:economics / Q000295:instrumentation*; D008904:Miniaturization; D009062:Mouth Neoplasms / Q000473:pathology*; D010783:Photometry / Q000191:economics / Q000295:instrumentation* / Q000379:methods; D010808:Physical Examination / Q000191:economics / Q000295:instrumentation*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D014481:United States; D014584:User-Computer Interface