title: Evidence for hydroxyl radical generation during lipid (linoleate) peroxidation.
abstract: The autoxidation of methyl linoleate in benzene at 37 degrees C by peroxyl radicals was found to generate hydroxyl radicals (.OH) from a secondary oxidation mechanism. The yield of hydroxyl radicals (approximately 2%) was determined by trapping these reactive radicals with benzene to give phenol. We propose that alphaC-H hydrogen abstraction from lipid hydroperoxides, the main autoxidation products, is the source of hydroxyl radicals.
authors.affiliation: Department of Chemistry, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Frenette
authors.forename: Juan C
authors.initials: JC
authors.lastname: Scaiano
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry; D017665:Hydroxyl Radical / Q000737:chemistry*; D019787:Linoleic Acid / Q000737:chemistry*; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000737:chemistry; D010545:Peroxides / Q000737:chemistry
chemical_list: D008054:Lipid Peroxides; D010545:Peroxides; C049375:perhydroxyl radical; D017665:Hydroxyl Radical; D019787:Linoleic Acid