title: First total synthesis of the phenolic 7,8-dihydro-8-oxoprotoberberine alkaloid, cerasonine.
abstract: First total synthesis of the phenolic protoberberine, cerasonine, was accomplished through a coupling reaction between o-toluamide and benzonitrile. This key step provided the 3-arylisoquinoline which was then successfully converted to 7,8-dihydro-8-oxoprotoberberine through an intramolecular S(N)2 reaction.
authors.affiliation: College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Buk-Gu, Kwangju, South Korea.
authors.forename: Thanh Nguyen
authors.initials: TN
authors.lastname: Le
authors.forename: Won-Jea
authors.initials: WJ
authors.lastname: Cho
mesh_terms: D001600:Berberine Alkaloids / Q000138:chemical synthesis*
chemical_list: D001600:Berberine Alkaloids; C530557:cerasonine; C009090:protoberberine