mPGES-1 knock-out mice are resistant to cancer-induced anorexia despite the absence of central mPGES-1 up-regulation in wild-type anorexic mice.
Anorexia-cachexia syndrome is a very common symptom observed in individuals affected by chronic inflammatory diseases. The present study was designed to address the possible involvement of the inducible microsomal prostaglandin E synthase-1 (mPGES-1) in the hypopaghia observed during these pathological states. To this end, we used a model of cancer-induced anorexia and we report here that despite the absence of up-regulation of the mPGES-1 enzyme within the brain during anorexia-cachexia syndrome, mPGES-1 knock-out mice exhibit resistance to tumor-induced anorexia and maintain their body mass.
Pecchi
E
E
Centre de Recherche en Neurobiologie-Neurophysiologie de Marseille (CRN2M), UMR 6231 CNRS, Université Paul Cézanne and Université de la Méditerranée, Marseille, France.
Dallaporta
M
M
Jean
A
A
Thirion
S
S
Troadec
J D
JD
D000818:Animals; D000855:Anorexia / Q000201:enzymology* / Q000209:etiology; D015153:Blotting, Western; D001921:Brain / Q000201:enzymology* / Q000276:immunology; D002100:Cachexia / Q000209:etiology; D016207:Cytokines / Q000096:biosynthesis; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D019746:Intramolecular Oxidoreductases / Q000235:genetics / Q000378:metabolism*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000150:complications*; D000071876:Prostaglandin-E Synthases; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015854:Up-Regulation
D016207:Cytokines; D019746:Intramolecular Oxidoreductases; D000071876:Prostaglandin-E Synthases; C000605865:Ptges protein, mouse