Central lactate metabolism regulates food intake.
The central nervous system regulates food intake (FI) and body weight (BW), but the associated mechanisms remain to be elucidated. Here we report that central injections of lactate reduced FI and BW in rodents. Inhibition of central lactate metabolism to pyruvate with the lactate dehydrogenase inhibitor oxamate abolished the central effects of lactate on FI and BW. Conversely, central injections of pyruvate recapitulated the effects of lactate. Finally, inhibition of central lactate metabolism prevented the ability of circulating lactate to lower FI and BW. Together, the data indicate that activation of central lactate metabolism lowers FI and BW.
Lam
Carol K L
CK
Department of Physiology, University of Toronto, 101 College Street, Toronto, Ontario, Canada.
Chari
Madhu
M
Wang
Penny Y T
PY
Lam
Tony K T
TK
D000818:Animals; D001835:Body Weight / Q000502:physiology; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism*; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D019344:Lactic Acid / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000494:pharmacology*; D008297:Male; D010072:Oxamic Acid / Q000494:pharmacology; D019289:Pyruvic Acid / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D019344:Lactic Acid; D019289:Pyruvic Acid; D010072:Oxamic Acid