title: [Studies on analgesic effects and sites of oxymatrine-carbenoxolone sodium complex].
abstract: OBJECTIVE
  To study the analgesic effects and sites of oxymatrine-carbenoxolone sodium complex (OCSC).
  
  
  METHODS
  Adopting formalin test, warm water tail-flick test and intracerebroventricularly (icv) injection to observe the analgesic effects of OCSC in mice.
  
  
  RESULTS
  Intraperitoneally injecting (ip) OCSC (75, 150 mg x kg(-1)) remarkedly inhibited the pain of mice in the formalin test and prolonged latent phases of tail-shrinking of mice, icy OCSC (1.875, 3.75, 7.5 mg x kg(-1)) significantly prolonged latent phases of tail-shrinking of mice, it had dose-dependent effect with concentration.
  
  
  CONCLUSIONS
  The result indicated that OCSC has obvious analgesic effects and its mechanism may be involved in central nervous system (CNS).
authors.affiliation: Department of Pharmacology, Ningxia Medical College, Yinchuan 750004, China.
authors.forename: Jun-Jun
authors.initials: JJ
authors.lastname: Zhou
authors.forename: Yuan-Xu
authors.initials: YX
authors.lastname: Jiang
authors.forename: Shao-Ju
authors.initials: SJ
authors.lastname: Jin
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Tao
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Liu
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000700:Analgesics / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002229:Carbenoxolone / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010146:Pain / Q000188:drug therapy; D011807:Quinolizines / Q000737:chemistry*; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000700:Analgesics; D002229:Carbenoxolone; D011807:Quinolizines; C037573:oxymatrine; D000093842:Matrines