Clostridium difficile pancolitis in adults with cystic fibrosis.
We report three cases of Clostridium difficile pancolitis in adults with cystic fibrosis (CF) in whom the presenting symptoms were atypical. All three required treatment with systemic steroids, in addition to oral vancomycin and metronidazole to achieve resolution of the colitis. This experience suggests that C. difficile colitis should be considered in individuals with CF presenting with non-specific abdominal symptoms.
Barker
H C
HC
Adult Cystic Fibrosis Centre, Papworth Hospital, Cambridge, CB23 3RE, UK. barkerhc@yahoo.com
Haworth
C S
CS
Williams
D
D
Roberts
P
P
Bilton
D
D
D000328:Adult; D016360:Clostridioides difficile / Q000302:isolation & purification*; D003550:Cystic Fibrosis / Q000150:complications*; D004359:Drug Therapy, Combination; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D013256:Steroids / Q000008:administration & dosage; D014640:Vancomycin / Q000008:administration & dosage
D013256:Steroids; D008795:Metronidazole; D014640:Vancomycin