title: Dercum's disease (Lipomatosis dolorosa): successful therapy with pregabalin and manual lymphatic drainage and a current overview.
abstract: Dercum's disease which is also termed lipomatosis dolorosa is a rare and relatively unknown disease. In this entity the upper arms, elbows, stomach wall, buttocks, thighs and knees are predominantly affected showing painful subcutaneous adipose tissue deposits. In addition severe hyperalgesia can be triggered by light pressure and touch. Analgesic and/or nonsteroidal antirheumatic drugs have usually only a minor or no effect. Here, we report a patient with Dercum's disease who was successfully treated with pregabalin and manual lymphatic drainage, and present a current overview of the literature.
authors.affiliation: Kerckhoff-Clinic, Bad Nauheim, Germany, U.Lange@kerckhoff-klinik.de
authors.forename: Uwe
authors.initials: U
authors.lastname: Lange
authors.forename: Peter
authors.initials: P
authors.lastname: Oelzner
authors.forename: Christine
authors.initials: C
authors.lastname: Uhlemann
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000274:Adiposis Dolorosa / Q000150:complications / Q000473:pathology / Q000628:therapy*; D000700:Analgesics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006930:Hyperalgesia / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D008209:Lymphedema / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D000069583:Pregabalin; D013396:Suction / Q000379:methods*; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid