title: A genome-wide linkage scan identifies multiple chromosomal regions influencing serum lipid levels in the population on the Samoan islands.
abstract: Abnormal lipid levels are important risk factors for cardiovascular diseases. We conducted genome-wide variance component linkage analyses to search for loci influencing total cholesterol (TC), LDL, HDL and triglyceride in families residing in American Samoa and Samoa as well as in a combined sample from the two polities. We adjusted the traits for a number of environmental covariates, such as smoking, alcohol consumption, physical activity, and material lifestyle. We found suggestive univariate linkage with log of the odds (LOD) scores > 3 for LDL on 6p21-p12 (LOD 3.13) in Samoa and on 12q21-q23 (LOD 3.07) in American Samoa. Furthermore, in American Samoa on 12q21, we detected genome-wide linkage (LOD(eq) 3.38) to the bivariate trait TC-LDL. Telomeric of this region, on 12q24, we found suggestive bivariate linkage to TC-HDL (LOD(eq) 3.22) in the combined study sample. In addition, we detected suggestive univariate linkage (LOD 1.9-2.93) on chromosomes 4p-q, 6p, 7q, 9q, 11q, 12q 13q, 15q, 16p, 18q, 19p, 19q and Xq23 and suggestive bivariate linkage (LOD(eq) 2.05-2.62) on chromosomes 6p, 7q, 12p, 12q, and 19p-q. In conclusion, chromosome 6p and 12q may host promising susceptibility loci influencing lipid levels; however, the low degree of overlap between the three study samples strongly encourages further studies of the lipid-related traits.
authors.affiliation: Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Karolina
authors.initials: K
authors.lastname: Aberg
authors.forename: Feng
authors.initials: F
authors.lastname: Dai
authors.forename: Guangyun
authors.initials: G
authors.lastname: Sun
authors.forename: Ember
authors.initials: E
authors.lastname: Keighley
authors.forename: Subba Rao
authors.initials: SR
authors.lastname: Indugula
authors.forename: Linda
authors.initials: L
authors.lastname: Bausserman
authors.forename: Satupaitea
authors.initials: S
authors.lastname: Viali
authors.forename: John
authors.initials: J
authors.lastname: Tuitele
authors.forename: Ranjan
authors.initials: R
authors.lastname: Deka
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Weeks
authors.forename: Stephen T
authors.initials: ST
authors.lastname: McGarvey
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D000704:Analysis of Variance; D002875:Chromosomes; D004493:Education; D004777:Environment; D005260:Female; D008040:Genetic Linkage; D015894:Genome, Human / Q000235:genetics*; D023281:Genomics; D006801:Humans; D008055:Lipids / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D009043:Motor Activity; D018947:Samoa; D012907:Smoking; D012984:Software
chemical_list: D008055:Lipids