title: Suspected cardiac toxicity to intravenous immunoglobulin used for treatment of scleromyxedema.
abstract: Scleromyxedema is a rare, generalized form of lichen myxedematosus, which may be associated with systemic involvement and can be fatal. The therapeutic options available provide partial or inconsistent response and are associated with significant adverse effects. We report a case of scleromyxedema with cardiac involvement, treated with low-dose intravenous immunoglobulin, with almost complete clearing of the skin lesions. The patient died after three cycles of treatment, possibly due to myocardial infarction.
authors.affiliation: Department of Dermatology and Venereology, Medical College, Thrissur; Medical College, Calicut, India. mpbinitha@sify.com
authors.forename: M P
authors.initials: MP
authors.lastname: Binitha
authors.forename: G
authors.initials: G
authors.lastname: Nandakumar
authors.forename: Daisy
authors.initials: D
authors.lastname: Thomas
mesh_terms: D000328:Adult; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004562:Electrocardiography; D017809:Fatal Outcome; D006331:Heart Diseases / Q000209:etiology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D007155:Immunologic Factors / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D012307:Risk Factors; D053718:Scleromyxedema / Q000175:diagnosis / Q000628:therapy*
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors