title: Low urinary 6-sulphatoxymelatonin concentrations in acute migraine.
abstract: Substantial evidence points to melatonin as playing a role in the regulation of circadian rhythms, sleep, and headache disorders. The objective of the study was to assess 6-sulphatoxymelatonin (aMT6s) levels in a large consecutive series of patients with migraine, comparing with controls. A total of 220 subjects were evaluated-146 had migraine and 74 were control subjects. Urinary samples were collected into the same plastic container since 8:00 p.m. to 8:00 a.m. of the next day (12-h period) and aMT6s was measured with quantitative ELISA technique. Among patients with migraine, 53% presented pain on the day of the urine samples collection. Their urinary aMT6s concentration was significantly lower than in the urine of patients without pain [14.0 +/- 7.3 vs. 49.4 +/- 19.0; t(143) = -15.1; 95% CI = -40.0 to -30.8; P < 0.001]. There was no significant difference in the aMT6s concentration of patients with migraine without pain on the day of their urine samples collection and controls [49.4 +/- 19.0 vs. 42.5 +/- 27.9; t(140) = 1.7; 95% CI = -1.2 to 14.8; P = 0.094]. To our knowledge, this is the first study to demonstrate reduction in melatonin levels during attacks in episodic and chronic migraine.
authors.affiliation: Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Marcelo Rodrigues
authors.initials: MR
authors.lastname: Masruha
authors.forename: Domingos Sávio
authors.initials: DS
authors.lastname: de Souza Vieira
authors.forename: Thais Soares Cianciarullo
authors.initials: TS
authors.lastname: Minett
authors.forename: José
authors.initials: J
authors.lastname: Cipolla-Neto
authors.forename: Eliova
authors.initials: E
authors.lastname: Zukerman
authors.forename: Luiz Celso Pereira
authors.initials: LC
authors.lastname: Vilanova
authors.forename: Mario Fernando Prieto
authors.initials: MF
authors.lastname: Peres
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives* / Q000652:urine; D008875:Middle Aged; D008881:Migraine Disorders / Q000145:classification / Q000652:urine*; D016017:Odds Ratio; D012189:Retrospective Studies
chemical_list: C054513:6-sulfatoxymelatonin; D008550:Melatonin