title: Effects of allopurinol on beer-induced increases in plasma concentrations of purine bases and uridine.
abstract: We investigated the effects of allopurinol on beer-induced changes in the plasma concentration and urinary excretion of purine bases. Five healthy subjects underwent three studies: ingestion of beer after taking 300 mg allopurinol (combination study); ingestion of beer alone; ingestion of allopurinol alone. Increased plasma concentrations and urinary excretion of hypoxanthine were greater in the combination study than the beer alone study. However, increases in total plasma purine base concentrations were greater in the beer alone study, even though increases in plasma uridine concentrations did not differ. Beer-induced increases in plasma concentrations of purine bases appear partially offset by increased urinary excretion of hypoxanthine after allopurinol, which also controls increases in plasma uric acid levels caused by alcoholic beverage ingestion.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan. inokuchi@hyo-med.ac.jp
authors.forename: Taku
authors.initials: T
authors.lastname: Inokuchi
authors.forename: Tuneyoshi
authors.initials: T
authors.lastname: Ka
authors.forename: Asako
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Sumio
authors.initials: S
authors.lastname: Takahashi
authors.forename: Zenta
authors.initials: Z
authors.lastname: Tsutsumi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Moriwaki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D000493:Allopurinol / Q000494:pharmacology*; D001515:Beer; D000431:Ethanol / Q000097:blood; D006801:Humans; D010117:Oxypurinol / Q000097:blood; D011687:Purines / Q000097:blood* / Q000652:urine; D014529:Uridine / Q000097:blood* / Q000652:urine
chemical_list: D011687:Purines; D000431:Ethanol; D000493:Allopurinol; D010117:Oxypurinol; D014529:Uridine