title: Glycation as an atherogenic modification of LDL.
abstract: OBJECTIVE
  To highlight the potential importance of glycation as an atherogenic modification of LDL in both diabetic and nondiabetic people.
  
  
  RESULTS
  Small dense LDL which is known to be most closely associated with atherogenesis is more susceptible to glycation than more buoyant LDL. Glycation and oxidation of LDL appear to be intimately associated.
  
  
  CONCLUSIONS
  Glycation of LDL occurs chiefly due to the nonenzymatic reaction of glucose and its metabolites with the free amino groups of lysine in which LDL is rich. Higher concentrations of glycated LDL are present in diabetic than in nondiabetic individuals, but even in the latter, there is generally more circulating glycated LDL than oxidatively modified LDL. Probably, oxidation and glycation of LDL are at least partially interdependent, but both prevent LDL receptor-mediated uptake and promote macrophage scavenger receptor uptake. The recognition that LDL glycation is at least as important as oxidation in atherogenesis may lead to improvements in our understanding of its mechanism and how to prevent it.
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
authors.forename: Nahla
authors.initials: N
authors.lastname: Younis
authors.forename: Reena
authors.initials: R
authors.lastname: Sharma
authors.forename: Handrean
authors.initials: H
authors.lastname: Soran
authors.forename: Valentine
authors.initials: V
authors.lastname: Charlton-Menys
authors.forename: Mohamed
authors.initials: M
authors.lastname: Elseweidy
authors.forename: Paul N
authors.initials: PN
authors.lastname: Durrington
mesh_terms: D050197:Atherosclerosis / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D007700:Kinetics; D010084:Oxidation-Reduction
chemical_list: D008078:Cholesterol, LDL