G-protein-coupled receptors and melanoma.
G-protein-coupled receptors (GPCR) are the largest family of receptors with over 500 members. Evaluation of GPCR gene expression in primary human tumors identified over-expression of GPCR in several tumor types. Analysis of cancer samples in different disease stages also suggests that some GPCR may be involved in early tumor progression and others may play a critical role in tumor invasion and metastasis. Currently, >50% of drug targets to various human diseases are based on GPCR. In this review, the relationships between several GPCR and melanoma development and/or progression will be discussed. Finally, the possibility of using one or more of these GPCR as therapeutic targets in melanoma will be summarized.
Lee
Hwa Jin
HJ
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Wall
Brian
B
Chen
Suzie
S
D000818:Animals; D051157:Frizzled Receptors / Q000235:genetics / Q000502:physiology; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D009857:Oncogenes / Q000502:physiology; D010980:Platelet Membrane Glycoproteins / Q000235:genetics / Q000502:physiology; D044102:Receptor, Melanocortin, Type 1 / Q000235:genetics / Q000502:physiology; D044463:Receptor, PAR-1 / Q000235:genetics / Q000502:physiology; D019707:Receptors, Chemokine / Q000235:genetics / Q000502:physiology; D017466:Receptors, Endothelin / Q000235:genetics / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000502:physiology*; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics / Q000502:physiology
D051157:Frizzled Receptors; D010980:Platelet Membrane Glycoproteins; D044102:Receptor, Melanocortin, Type 1; D044463:Receptor, PAR-1; D019707:Receptors, Chemokine; D017466:Receptors, Endothelin; D043562:Receptors, G-Protein-Coupled; D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1; C039351:platelet activating factor receptor