APOE genotype is associated with left-handedness and visuospatial skills in children.
We sought to investigate whether apolipoprotein E (APOE) genotype is associated with unique profiles of cognitive functioning during early-life. School-aged children (N=147) received standardized achievement tests, the Rey-Osterrieth Complex Figure Test (Copy Condition; RCFT-CC), assessment of hand dominance for writing, and buccal swab testing to determine their APOE genotype. Significant differences were found on the RCFT-CC, with epsilon 2-positive children performing worse on this measure relative to both epsilon 3/3 (p=0.032) and epsilon 4-positive children (p=0.018). Further, a higher prevalence of left-hand dominance for writing was observed among epsilon 2-positive children (29.2%) relative to epsilon 3/3 (8.9%) and epsilon 4-positive children (6.1%; p=0.012), although this finding did not account for the observed group differences on the RCFT-CC. Findings raise the possibility that in childhood, the epsilon 2 allele may be associated with: (a) decreased functioning in certain cognitive domains; (b) factors associated with atypical hemispheric dominance. Results may be consistent with the theory of antagonistic pleiotropy, which suggests that APOE may have different protective effects at different developmental stages.
Bloss
Cinnamon S
CS
SDSU/UCSD Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, Suite 103, San Diego, CA 92120-4913, USA. cbloss@scripps.edu
Delis
Dean C
DC
Salmon
David P
DP
Bondi
Mark W
MW
D000124:Achievement; D000293:Adolescent; D000483:Alleles; D000704:Analysis of Variance; D001057:Apolipoproteins E / Q000235:genetics*; D002648:Child; D003071:Cognition / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D018579:Patient Selection; D013028:Space Perception / Q000502:physiology*; D018709:Statistics, Nonparametric; D014796:Visual Perception / Q000235:genetics*
D001057:Apolipoproteins E