title: Reduced interleukin-17 expression of Burkholderia pseudomallei-infected peripheral blood mononuclear cells of diabetic patients.
abstract: Burkholderia pseudomallei is the causative agent of melioidosis. One of the main risk factors for B. pseudomallei infection in endemic areas is diabetes mellitus. The present study investigated IL-17 mRNA and protein expression by peripheral blood mononuclear cells in response to B. pseudomallei infection in 10 diabetic patients in comparison to 10 healthy blood donors. The IL-17 expression in diabetic patients was significantly lower (p < 0.05) than in the controls. However, IL-23 mRNA expression of the 2 groups was comparable. The present findings suggest that melioidosis affects T cell IL-17 production and that patients with diabetes mellitus have a defective IL-17 production in response to this type of infection.
authors.affiliation: Department of Medicine, Faculty of Medicine, Naresuan University, Thailand.
authors.forename: Sutatip
authors.initials: S
authors.lastname: Pongcharoen
authors.forename: Pannika Niumsup
authors.initials: PN
authors.lastname: Ritvirool
authors.forename: Donruedee
authors.initials: D
authors.lastname: Sanguansermsri
authors.forename: Pairat
authors.initials: P
authors.lastname: Chanchan
authors.forename: Poj
authors.initials: P
authors.lastname: Jienmongkol
authors.forename: Puntharee
authors.initials: P
authors.lastname: Butkhamchot
authors.forename: Prateep
authors.initials: P
authors.lastname: Warnnissorn
authors.forename: Napatawn
authors.initials: N
authors.lastname: Banchuin
authors.forename: Stitaya
authors.initials: S
authors.lastname: Sirisinha
mesh_terms: D000328:Adult; D016957:Burkholderia pseudomallei / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000097:blood* / Q000235:genetics; D053759:Interleukin-23 / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D008554:Melioidosis / Q000150:complications / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23; D012333:RNA, Messenger