Urate transport across the apical membrane of renal proximal tubules.
Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to urate transport have been identified. In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or "urate transportsome," that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Elucidation of urate transportsome will lead to the new drug development for hyperuricemia.
Endou
Hitoshi
H
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan. endouh@kyorin-u.ac.jp
Anzai
Naohiko
N
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000166:cytology* / Q000378:metabolism*; D008565:Membrane Proteins; D051379:Mice; D027501:Monocarboxylic Acid Transporters / Q000378:metabolism; D027361:Organic Anion Transporters / Q000378:metabolism*; D027701:Organic Cation Transport Proteins / Q000378:metabolism; D050611:Sodium-Phosphate Cotransporter Proteins, Type III / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism*
D002352:Carrier Proteins; D008565:Membrane Proteins; D027501:Monocarboxylic Acid Transporters; D027361:Organic Anion Transporters; D027701:Organic Cation Transport Proteins; C484659:PDZK1 protein, human; C491241:SLC22A12 protein, human; D050611:Sodium-Phosphate Cotransporter Proteins, Type III; C103862:urate transporter; D014527:Uric Acid