title: Genome-wide identification of haploinsufficiency in fission yeast.
abstract: Abnormal phenotypes resulting from haploinsufficiency (HI) are due to the loss of one allele. Recent studies in budding yeast have shown that HI originates from insufficient protein levels or from a stoichiometric imbalance between subunits of protein complexes. In humans, however, HI often involves transcription factors. Therefore, the species differences in HI and the molecular mechanisms of species-specific HI remain under investigation. In this study, HI in fission yeast was systematically surveyed. HI in fission yeast affected genes related to signaling and to basic cellular processes, as observed in budding yeast. These results suggest that there are species differences in HI and that the HI that occurs in fission yeast is intermediate to and HI in budding yeast and humans.
authors.affiliation: Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.
authors.forename: Seung Tae
authors.initials: ST
authors.lastname: Baek
authors.forename: Sangjo
authors.initials: S
authors.lastname: Han
authors.forename: Miyoung
authors.initials: M
authors.lastname: Nam
authors.forename: Young-Dae
authors.initials: YD
authors.lastname: Kim
authors.forename: Lila
authors.initials: L
authors.lastname: Kim
authors.forename: Hyun-Jee
authors.initials: HJ
authors.lastname: Lee
authors.forename: Kyung-Sun
authors.initials: KS
authors.lastname: Heo
authors.forename: Hyemi
authors.initials: H
authors.lastname: Lee
authors.forename: Minho
authors.initials: M
authors.lastname: Lee
authors.forename: Song-Kyu
authors.initials: SK
authors.lastname: Park
authors.forename: Pil Jae
authors.initials: PJ
authors.lastname: Maeng
authors.forename: Youngwoo
authors.initials: Y
authors.lastname: Park
authors.forename: Sunghou
authors.initials: S
authors.lastname: Lee
authors.forename: Dong-Uk
authors.initials: DU
authors.lastname: Kim
authors.forename: Dongsup
authors.initials: D
authors.lastname: Kim
authors.forename: Kwang-Lae
authors.initials: KL
authors.lastname: Hoe
mesh_terms: D000483:Alleles; D005656:Fungal Proteins / Q000235:genetics; D017353:Gene Deletion; D018628:Gene Dosage; D005800:Genes, Fungal; D016681:Genome, Fungal; D010641:Phenotype; D012568:Schizosaccharomyces / Q000235:genetics* / Q000254:growth & development; D013045:Species Specificity
chemical_list: D005656:Fungal Proteins