Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters.
OBJECTIVE
To investigate the relationship between the expression of P120 and the clinicopathologic parameters in intrahepatic cholangiocarcinoma (ICC).


METHODS
An immunohistochemical study of E-cadherin and P120 catenin was performed on 42 specimens of ICC with a Dako Envision kit.


RESULTS
The expression of E-cadherin and P120 was reduced in 27 cases (64.3%) and 31 cases (73.8%), respectively. Both E-cadherin and P120 expressions were significantly correlated with the tumor histological grade (chi2 = 9.333, P = 009 and chi2 = 11.71, P = 0.003), TNM stage (chi2= 8.627, P = 0.035 and chi2 = 13.123, P = 0.004), intrahepatic metastasis (chi2= 7.292, P = 0.007 and chi2 = 4.657, P = 0.041, respectively) and patients' survival (chi2= 6.351, P = 0.002 and chi2 = 4.023, P = 0.000, respectively). In addition, the expression of P120 was in concordance with that of E-cadherin (chi2 = 13.797, P = 0.000), indicating that the expression of P120 may be dependent on that of E-cadherin. Finally, only P120 expression was found to be an independent prognostic factor in Cox regression model (r = 0.088, P = 0.049).


CONCLUSIONS
Down-regulated expression of E-cadherin and P120 occurs frequently in ICC and contributes to the progression and development of tumor. Both of them may be valuable biologic markers for predicting tumor invasion, metastasis and patients' survival, but only P120 is an independent prognostic factor for ICC.
Zhai
Bo
B
Department of Ultrasonic Intervention, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.
Yan
He-Xin
HX
Liu
Shu-Qin
SQ
Chen
Lei
L
Wu
Meng-Chao
MC
Wang
Hong-Yang
HY
D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D001653:Bile Ducts, Intrahepatic / Q000737:chemistry* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis*; D015820:Cadherins / Q000032:analysis; D051177:Catenins; D015815:Cell Adhesion Molecules / Q000032:analysis*; D018281:Cholangiocarcinoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010750:Phosphoproteins / Q000032:analysis*; D011379:Prognosis; D016016:Proportional Hazards Models; D000095002:Delta Catenin
D014408:Biomarkers, Tumor; D015820:Cadherins; D051177:Catenins; D015815:Cell Adhesion Molecules; D010750:Phosphoproteins; D000095002:Delta Catenin; C000722347:CTNND1 protein, human