[Efficacy of monotherapy with 15 antihypertensive agents in treating essential hypertension assessed by 24-hour ambulatory blood pressure monitoring].
OBJECTIVE
To evaluate the efficacy of the monotherapy of 15 agents in treating essential hypertension.


METHODS
After 2-week wash-out, a total of 370 patients with seated diastolic blood pressure 95-114 mmHg and seated systolic blood pressure < 180 mmHg were randomized to different therapeutic groups. 24-hour ambulatory blood pressure monitoring was performed before medication and at the end of 8 weeks.


RESULTS
All the agents significantly reduced the 24 hour mean blood pressures after treatment except doxazosin, terazosin, and torasemide.


CONCLUSIONS
The result suggested that the angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers and long-acting calcium antagonists were effective in treating essential hypertension, while the low-dose doxazosin, terazosin and torasemide can be used for combination therapy but not for monotherapy.
Hua
Cong-Xiao
CX
Key Laboratory of Clinical Trial Research in Cardiovascular Drugs, Ministry of Health, Fuwai Cardiovascular Diseases Hospital, CAMS and PUMC, Beijing 100037, China.
Hua
Lu
L
Li
Na
N
Wang
Li
L
Pang
Hui-Min
HM
Ming
Guang-Hua
GH
Huang
Yan
Y
Cheng
Xiao-Ru
XR
Liu
Hong
H
Wu
Ying
Y
Xu
Li
L
Kang
Jian
J
Xu
Zhi-Min
ZM
Li
Yi-Shi
YS
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000145:classification / Q000627:therapeutic use*; D018660:Blood Pressure Monitoring, Ambulatory; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D017292:Doxazosin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D011224:Prazosin / Q000031:analogs & derivatives / Q000627:therapeutic use; D013449:Sulfonamides / Q000627:therapeutic use; D000077786:Torsemide; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D013449:Sulfonamides; C041226:Terazosin; D017292:Doxazosin; D000077786:Torsemide; D011224:Prazosin