Immunohistochemical expression of MMPs 1, 7, and 26 in syndrome and nonsyndrome odontogenic keratocysts.
OBJECTIVE
The objective of this study was to analyze the expression of matrix metalloproteinases (MMPs) 1, 7, and 26 in odontogenic keratocysts (OKCs) associated with Gorlin syndrome (SOKCs) and nonsyndrome OKCs (NSOKCs).


METHODS
Twenty-one SOKCs and 20 NSOKCs were evaluated for epithelial expression of MMP-1, MMP-7, and MMP-26 and for mesenchymal expression of MMP-1 by immunohistochemistry.


RESULTS
Strong epithelial positivity to MMP-1 was observed in 76% of SOKCs and in 15% of NSOKCs (P < .05). Strong mesenchymal immunoreactivity to MMP-1 was observed in 38% of SOKCs and in 20% of NSOKCs (P > .05). Epithelial immunoreactivity to MMP-7 was strongly positive in 67% of SOKCs and in 40% of NSOKCs (P > .05). For MMP-26, strong positivity was found in 62% of SOKCs, in contrast to 35% of NSOKCs (P > .05).


CONCLUSIONS
MMPs-1, -7 and -26 may play important roles in the biology of OKCs. Furthermore, the presence of these proteases at higher levels in SOKCs may help to explain increased OKC aggressiveness associated with nevoid basal cell carcinoma syndrome.
Cavalcante
Roberta Barroso
RB
Department of Oral Pathology, School of Dentistry, University of Fortaleza, Ceará, Brazil.
Pereira
Karuza Maria Alves
KM
Nonaka
Cassiano Francisco Weege
CF
Nogueira
Renato Luiz Maia
RL
de Souza
Lélia Batista
LB
D001478:Basal Cell Nevus Syndrome / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis*; D020783:Matrix Metalloproteinase 7 / Q000096:biosynthesis*; D053505:Matrix Metalloproteinases, Secreted / Q000096:biosynthesis*; D009807:Odontogenic Cysts / Q000201:enzymology*; D013577:Syndrome
D007633:Keratins; C410599:MMP26 protein, human; D053505:Matrix Metalloproteinases, Secreted; D020783:Matrix Metalloproteinase 7; D020781:Matrix Metalloproteinase 1