title: Complement factor H Y402H polymorphism, plasma concentration and risk of coronary artery disease.
abstract: BACKGROUND
  Inflammation plays an important role in coronary artery disease (CAD). Complement Factor H (CFH) gene has been analyzed in relation to CAD in several studies with conflicting results. The aim of the present study was to investigate the association between the CFH Y402H polymorphism and CAD in Chinese.
  
  
  RESULTS
  About 336 patients were enrolled, included 166 patients with CAD and 170 controls. The SNP at CFH Y402H was genotyped by ligase detection reaction and plasma levels of CFH were assayed by enzyme-linked immunosorbent assay. Analysis of genotype frequencies did not reveal any significant difference between CAD patients and controls. There were significant differences in the frequencies of C allele and C allele carriers between early-onset CAD and controls. After adjustment of clinical parameters, significant association was identified for CFH Y402H polymorphism, with C allele carriers having a higher risk of early-onset CAD than carriers of TT genotype (odds ratio [OR] 4.66, 95% CI: 1.23-17.62, P = 0.02). There was no difference of plasma CFH levels between CAD group and controls.
  
  
  CONCLUSIONS
  CFH Y402H polymorphism is associated with early-onset CAD in Chinese.
authors.affiliation: Clinical Medical College of Southeast University, Nanjing, 210009, People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Qian
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.forename: Genshan
authors.initials: G
authors.lastname: Ma
authors.forename: Yibo
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Chengxing
authors.initials: C
authors.lastname: Shen
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Yao
authors.forename: Jiandong
authors.initials: J
authors.lastname: Ding
authors.forename: Qiming
authors.initials: Q
authors.lastname: Dai
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D017242:Complement Factor H / Q000235:genetics*; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D017242:Complement Factor H