title: Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides.
abstract: Protein tyrosine phosphatases (PTPs) are cysteine-dependent enzymes that play a central role in cell signaling. Organic hydroperoxides cause thiol-reversible, oxidative inactivation of PTP1B in a manner that mirrors the endogenous signaling agent hydrogen peroxide.
authors.affiliation: Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211, USA.
authors.forename: Sanjib
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: Jason N
authors.initials: JN
authors.lastname: Labutti
authors.forename: Derrick R
authors.initials: DR
authors.lastname: Seiner
authors.forename: Kent S
authors.initials: KS
authors.lastname: Gates
mesh_terms: D003545:Cysteine / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010463:Peracetic Acid / Q000494:pharmacology; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013438:Sulfhydryl Compounds / Q000494:pharmacology
chemical_list: D013438:Sulfhydryl Compounds; D006861:Hydrogen Peroxide; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D005978:Glutathione; D010463:Peracetic Acid; D003545:Cysteine