A new kid on the TGFbeta block: TAZ controls Smad nucleocytoplasmic shuttling.
A recent study from Varelas et al. in Nature Cell Biology reveals a role for the transcriptional regulator TAZ in TGFbeta signaling. Not only does TAZ couple phospho-Smads to the transcriptional machinery, it is also essential for their nuclear accumulation.
Wrighton
Katharine H
KH
Michael E. DeBakey Department of Surgery, Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Dai
Fangyan
F
Feng
Xin-Hua
XH
D021581:Active Transport, Cell Nucleus; D000217:Acyltransferases; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010766:Phosphorylation; D015398:Signal Transduction; D051785:Smad Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D019485:Bone Morphogenetic Proteins; D051785:Smad Proteins; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D000217:Acyltransferases; C108675:TAFAZZIN protein, human