Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats.
A 3-week chronic mild stress (CMS) protocol decreased sucrose preference of rats and increased immobility in the forced swim test. It also induced social avoidance and increased grooming, but acted as if reducing anxiety in the plus-maze. Sucrose preference and social avoidance, but not other measures of the behaviour, showed significant correlation. We conclude that CMS-induced depression-like behaviour is associated with social avoidance, a seemingly anxiety-related measure, but not with other anxiety-like traits in rats.
Kompagne
Hajnalka
H
Department of Preclinical Research, EGIS Pharmaceuticals Plc., Budapest, Hungary.
Bárdos
György
G
Szénási
Gábor
G
Gacsályi
István
I
Hársing
László G
LG
Lévay
György
G
D000818:Animals; D001007:Anxiety / Q000503:physiopathology* / Q000523:psychology; D001522:Behavior, Animal / Q000502:physiology*; D003863:Depression / Q000503:physiopathology / Q000523:psychology; D005106:Exploratory Behavior / Q000502:physiology; D005518:Food Preferences / Q000502:physiology / Q000523:psychology; D006120:Grooming / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical / Q000379:methods; D012919:Social Behavior; D013315:Stress, Psychological / Q000503:physiopathology* / Q000523:psychology; D013395:Sucrose / Q000008:administration & dosage; D013550:Swimming / Q000523:psychology; D013997:Time Factors
D013395:Sucrose