Adult T-cell leukemia/lymphoma in an adolescent presenting with skin lesions.
Adult T-cell leukemia/lymphoma is a T-cell malignancy caused by the human T-cell lymphotropic virus-I. Adult T-cell leukemia/lymphoma is primarily a disease of adults due to the long latency period between initial infection and development of leukemia. We present a case of acute adult T-cell leukemia/lymphoma in an adolescent. Skin lesions had appeared 3 years earlier and were the initial sign of human T-cell lymphotropic virus-I infection and T-cell malignancy. Her disease failed to respond to both intensive chemotherapy and antiviral therapy. Cutaneous lesions are sometimes the initial sign of adult T-cell leukemia/lymphoma and early recognition is imperative.
Lucas
Catherine T
CT
Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Gillis
Kendra J
KJ
Ness
Jayne M
JM
Hammers
Yuki A
YA
Crawford
David F
DF
Kelly
David R
DR
Theos
Amy
A
D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis; D015480:Deltaretrovirus Antibodies / Q000032:analysis; D018562:Disease Transmission, Infectious; D017809:Fatal Outcome; D005260:Female; D015490:HTLV-I Infections / Q000635:transmission*; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis* / Q000821:virology; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis* / Q000821:virology; D012867:Skin / Q000473:pathology / Q000821:virology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000821:virology; D065227:Transfusion Reaction
D015703:Antigens, CD; D015480:Deltaretrovirus Antibodies