Palm-sized biodetection system based on localized surface plasmon resonance.
We present a complete palm-sized, battery-operated biodetection system based on highly sensitive localized surface plasmon resonance (LSPR). We have replaced the spectrum analyzer by four pulse-powered light-emitting diodes (LED), each with different emission spectra. The reflected light beams from all LEDs were detected by a single photodiode. Its composite output current was demultiplexed by a four-channel lock-in amplifier. Device performance was demonstrated using an LSPR chip covered with a mixture of ethanol/water and 2-propanol/water at different concentrations. The miniaturized system does not require any external power supply or personal computer and it is therefore suitable for point-of-care and field applications.
Neuzil
Pavel
P
Institute of Microelectronics, 11 Science Park Road, Singapore Science Park II, Singapore 117685. pavel@ime.a-star.edu.sg
Reboud
Julien
J
D004867:Equipment Design; D008904:Miniaturization; D019095:Point-of-Care Systems; D020349:Surface Plasmon Resonance / Q000295:instrumentation*