title: Effect of ivelip and sodium nitroprusside on 5-HT, glutathione and lipid peroxidation in normal and malnourished rat brain.
abstract: We examined the effect of experimental malnutrition and diet supplementation of parameters of central nervous system damage. Wistar rats were fed during 30 days and classified as malnourished (MN, 7% protein content diet) or well-nourished (WN, 23% protein content diet), were grouped and treated as follows: I-control; II-SNP (20 microg/kg); IIl-Ivelip (280 mg/kg) and IV-Ivelip + sodium nitroprusside (SNP). Levels of lipid peroxidation (TBARS), glutathione (GSH), tryptophan (Trp) and serotonin (5-HT) were assessed in brain by liquid chromatography. TBARS and GSH levels increased significantly (p < 0.05) in MN vs. WN rats that did not receive Ivelip. No significant differences were observed in TBARS and GSH among rats that received Ivelip or SNP. The weight of rats decreased significantly (p < 0.05) in all MN groups in relation to the WN groups. Hemoglobin (Hb) levels increased significantly (p < 0.05) in MN and WN groups that received Ivelip. 5-HT levels increased significantly (p < 0.05) in all MN groups. Trp levels increased significantly (p < 0.05) in the WN + Ivelip group vs. control. Early malnutrition induces changes in the metabolism of biogenic amines and this condition may promote oxidative injury of the brain.
authors.affiliation: Laboratorio de Neuroquímica, Instituto Nacional de Pediatría (INP), México.
authors.forename: David
authors.initials: D
authors.lastname: Calderón Guzmán
authors.forename: Ivonne
authors.initials: I
authors.lastname: Espitia Vázquez
authors.forename: Gerardo
authors.initials: G
authors.lastname: Barragán Mejía
authors.forename: Norma
authors.initials: N
authors.lastname: Osnaya Brizuela
authors.forename: Ernestina
authors.initials: E
authors.lastname: Hernández García
authors.forename: Hugo
authors.initials: H
authors.lastname: Juárez-Olguín
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D004032:Diet; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D044342:Malnutrition / Q000378:metabolism*; D009599:Nitroprusside / Q000494:pharmacology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D011502:Protein-Energy Malnutrition / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D013024:Soybean Oil / Q000494:pharmacology*; D014280:Triglycerides / Q000494:pharmacology; D014364:Tryptophan / Q000378:metabolism
chemical_list: D005217:Fat Emulsions, Intravenous; D006454:Hemoglobins; D014280:Triglycerides; D009599:Nitroprusside; D012701:Serotonin; D013024:Soybean Oil; D014364:Tryptophan; D005978:Glutathione