[Aging-associated changes in cardiac function and their prevention].
Aging associated changes in cardiac contraction, Ca(2+) homeostasis and their neurohumoral regulations have been studied using rodents. The changes can be understood not only to reduce energy consumption but also to be susceptible to Ca(2+) overload, possibly leading arrhythmia and cell death. N-3 polyunsaturated fatty acid is reported to prevent cardiac Ca(2+) overload. Its content in the cellular membrane is reduced in aged cardiomyocytes, suggesting that the aging-associated change in n-3 fatty acid content is related to the changes in cardiac function. Ingestion balance between n-3 and n-6 fatty acids may affect on the risk of cardiovascular diseases associated with aging.
Nishimaru
Kazuhide
K
Bio Labo Inc.
D000262:Adenylyl Cyclases / Q000502:physiology; D000375:Aging / Q000502:physiology*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology; D002118:Calcium / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000209:etiology; D016232:Endothelins / Q000502:physiology; D004734:Energy Metabolism; D015525:Fatty Acids, Omega-3 / Q000378:metabolism / Q000502:physiology; D043371:Fatty Acids, Omega-6; D006801:Humans; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000502:physiology
D016232:Endothelins; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D011943:Receptors, Adrenergic, beta; D000262:Adenylyl Cyclases; D002118:Calcium