title: Heterotrimeric G protein mediated regulation of proteinase production in Aspergillus nidulans.
abstract: Extracellular proteinase production induced by carbon starvation was studied in a series of heterotrimeric G protein signaling pathway mutants of Aspergillus nidulans. All the mutants tested--including deltafadA (Galpha), deltasfaD (Gbeta), deltagpgA (Ggamma) and deltasfgA (regulator of FadA signaling)--showed an elevated proteinase production after glucose depletion. Our results strongly support the view that during growth, FadA/SfaD/GpgA G protein signaling inhibits proteinase production via both Galpha and Gbetagamma subunits, and all conditions, which are not sufficient to support vegetative growth and, hence, inhibit this type of G protein signaling, elevate extracellular proteinase activities.
authors.affiliation: Department of Microbial Biotechnology and Cell Biology, Faculty of Science and Technology, University of Debrecen, P.O. Box 63, H-4010 Debrecen, Hungary. emri@freemail.hu
authors.forename: Tamás
authors.initials: T
authors.lastname: Emri
authors.forename: Melinda
authors.initials: M
authors.lastname: Szilágyi
authors.forename: Anikó
authors.initials: A
authors.lastname: Justyák
authors.forename: István
authors.initials: I
authors.lastname: Pócsi
mesh_terms: D001233:Aspergillus nidulans / Q000201:enzymology* / Q000502:physiology*; D005656:Fungal Proteins / Q000096:biosynthesis* / Q000235:genetics; D017353:Gene Deletion; D015966:Gene Expression Regulation, Fungal; D005947:Glucose / Q000378:metabolism; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D016254:Mutagenesis, Insertional; D010447:Peptide Hydrolases / Q000096:biosynthesis*; D015398:Signal Transduction
chemical_list: D005656:Fungal Proteins; D010447:Peptide Hydrolases; D020962:Heterotrimeric GTP-Binding Proteins; D005947:Glucose