Stem cell regulation by JAK/STAT signaling in Drosophila.
Stem cells have become one of the "buzz" topics in the last decade or so. One of the best systems to study adult stem cells in vivo is in the model organism, Drosophila melanogaster. One hundred years of genetic analysis, a sequenced and highly annotated genome and genomics makes this a difficult organism to avoid. The JAK/STAT pathway has been shown to regulate stem cells during haematopoiesis and gametogenesis in Drosophila. In this review we cover the current literature and contrast each group of stem cells with respect to JAK/STAT signaling.
Gregory
Lorna
L
Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
Came
Paul J
PJ
Brown
Stephen
S
D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000502:physiology; D005260:Female; D005718:Gametogenesis / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology; D053612:Janus Kinases / Q000378:metabolism*; D008297:Male; D010053:Ovary / Q000378:metabolism; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000502:physiology*; D013737:Testis / Q000378:metabolism
D029721:Drosophila Proteins; D050791:STAT Transcription Factors; D053612:Janus Kinases