title: Testis specific lactate dehydrogenase as target for immunoliposomes.
abstract: OBJECTIVE
  Is it possible to deliver therapeutic agents to testis through specific targeting?
  
  
  METHODS
  Immunoliposomes are designed by incorporating antibodies to lactate dehydrogenase-C4 (LDH-C(4)), which is the product of a testis specific gene. Their targeting and delivering ability is investigated in vitro and in vivo.
  
  
  RESULTS
  It is observed that LDHC(4)-immunoliposomes are able to discriminate and recognize antigens on spermatozoa and testes both in vitro and in vivo.
  
  
  CONCLUSIONS
  Specific targeting through LDH-C(4) appears to be a feasible strategy for delivering therapeutic as well as anti-spermatogenic agents to testis.
authors.affiliation: Department of Biochemistry, Molecular Biology and Cell Biology Northwestern University, Evanston, IL 60208, USA. ranjna_dutta@rediffmail.com
authors.forename: Ranjna C
authors.initials: RC
authors.lastname: Dutta
authors.forename: Erwin
authors.initials: E
authors.lastname: Goldberg
mesh_terms: D000818:Animals; D000906:Antibodies / Q000008:administration & dosage*; D000918:Antibody Specificity; D015153:Blotting, Western; D016503:Drug Delivery Systems / Q000379:methods*; D004797:Enzyme-Linked Immunosorbent Assay; D007527:Isoenzymes / Q000008:administration & dosage / Q000276:immunology / Q000493:pharmacokinetics; D007770:L-Lactate Dehydrogenase / Q000008:administration & dosage* / Q000276:immunology / Q000493:pharmacokinetics; D008081:Liposomes / Q000008:administration & dosage* / Q000276:immunology / Q000493:pharmacokinetics; D008297:Male; D051379:Mice; D013094:Spermatozoa / Q000276:immunology; D013737:Testis / Q000276:immunology*; D014018:Tissue Distribution
chemical_list: D000906:Antibodies; D007527:Isoenzymes; D008081:Liposomes; D007770:L-Lactate Dehydrogenase; C409673:lactate dehydrogenase C4