title: Assessment of current serum levels of PCDD/Fs, dl-PCBs and PBDEs in a Dutch cohort with known perinatal PCDD/F exposure.
abstract: As part of a longitudinal cohort study, now in its second decade, we determined PCDDs/Fs dl-PCBs and PBDEs in serum of adolescents with known perinatal PCDD/F exposure. Of the original cohort, 33 adolescents aged 14-19 years, who had been studied previously during their neonatal (n=60), toddler and pre-pubertal period (n=41) agreed to participate in the current follow-up. PCDD/F-, dl-PCB- and PBDE congeners were measured using GC/MS. Current serum levels of PCDD/Fs determined in our cohort were relatively low (mean of 2.2 pg/g) compared to the perinatal exposure. No correlation between perinatal exposure and current serum PCDD/F was found. Planar PCB TEQ levels were 2.2 pg/g. Current summation operatorPBDE levels were 8.7 ng/g lipid. There was one outlier with a summation operatorPBDE of 74 ng/g lipid. The presence of this high value indicates that the exposure pathway is different from PCDD/F and PCB, most likely by dust and food contaminated with dust. Concluding we can say that current PCDD/F levels are quite low compared to the perinatal PCDD/F exposure of the cohort. PBDE levels however are relatively high compared to other European countries, more research on possible health effects of these levels, especially for subjects with outlier concentrations, should be performed.
authors.affiliation: Department of Paediatrics and Neonatology, Emma Children's Hospital Academic Medical Centre, Amsterdam, The Netherlands. M.M.Leijs@amc.uva.nl
authors.forename: M M
authors.initials: MM
authors.lastname: Leijs
authors.forename: T
authors.initials: T
authors.lastname: van Teunenbroek
authors.forename: K
authors.initials: K
authors.lastname: Olie
authors.forename: J G
authors.initials: JG
authors.lastname: Koppe
authors.forename: G W
authors.initials: GW
authors.lastname: ten Tusscher
authors.forename: W M C
authors.initials: WM
authors.lastname: van Aalderen
authors.forename: P
authors.initials: P
authors.lastname: de Voogt
mesh_terms: D000293:Adolescent; D000328:Adult; D001572:Benzofurans / Q000097:blood*; D015331:Cohort Studies; D004781:Environmental Exposure / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009426:Netherlands; D011078:Polychlorinated Biphenyls / Q000097:blood*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000097:blood; D011108:Polymers
chemical_list: D001572:Benzofurans; D000072317:Polychlorinated Dibenzodioxins; D011108:Polymers; C016068:polychlorodibenzofuran; D011078:Polychlorinated Biphenyls