Risk of thrombogenicity among nonionic radiocontrast agents.
Several contrast agents have been approved in the United States for radiographic imaging purposes. Most of the older ionic, high-osmolar contrast agents are no longer used because of their side effect profile. Therefore, newer nonionic, low or iso-osmolar contrast agents have been widely accepted as an alternative due to their improved tolerability and safety. We investigated the thrombogenicity of the 6 different nonionic radiocontrast media in terms of their platelet reactivity and noted some minor differences among them. In the 50% contrast concentration group, all of the nonionic contrast agents inhibited aggregation, whereas in the 10% contrast concentration group, all agents showed similar aggregation curves in comparison to the normal control. At 50% contrast concentration, the inhibitory effect of aggregation appeared to be related to the inhibition of calcium mobilization, which may be one of the mechanistic effects.
Georgakis
Alexander
A
Division of Cardiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
Ener
Rasih Atilla
RA
Jin
Jianguo
J
Kunapuli
Satya
S
Fiss
David
D
Leech
Stephen H
SH
Wolf
Nelson M
NM
Van Decker
William A
WA
D001792:Blood Platelets / Q000187:drug effects; D006328:Cardiac Catheterization / Q000379:methods*; D003287:Contrast Media / Q000009:adverse effects* / Q000494:pharmacology; D003328:Coronary Thrombosis / Q000139:chemically induced* / Q000453:epidemiology* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007472:Iohexol / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology; D007479:Iopamidol / Q000009:adverse effects / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D012307:Risk Factors; D014283:Triiodobenzoic Acids / Q000009:adverse effects / Q000494:pharmacology
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C038192:iopromide; C055357:ioxilan; C044834:iodixanol; D007479:Iopamidol; C054871:ioversol