[Optimization of matrix formulation of effective parts cataplasm of Pogostemon cablin by uniform design].
OBJECTIVE
To optimize the matrix formulation of the effective part Cataplasm of Pogostemon Cablin.


METHODS
The optimal preparation prescription was selected by U17 (17(11)) uniform design,and the tacking strength, cohesive strength and transdermal speed constant were used as test indexes. The equations of three test indexes were established by SPSS. With analysis of the contribution of factors by SPSS regression, the optimal matrix formulation was acquired.


RESULTS
The optimal matrix formulation is carbopol U10-NoveriteTM7s-glycerine-sorbitol-kaolin-citric acid-aluminum trichloride (1.0:5.0:20:2.0:2.0:0.25:0.2).


CONCLUSIONS
The matrix has good adhesive property, proper drug release rate, desirable hemocompatibility with the extractions of Pogostemon cablin.
Wang
Xiao-Gen
XG
Guang Dong Food and Drug Vocational College, Guangzhou 510520, China. wangxiaogen404@126.com
Zou
Yu-Fan
YF
Chen
Yu-Zhen
YZ
D000268:Adhesiveness; D001672:Biocompatible Materials / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000378:metabolism; D019686:Lamiaceae / Q000737:chemistry* / Q000378:metabolism; D012044:Regression Analysis; D012869:Skin Absorption; D014835:Volatilization
D001672:Biocompatible Materials; D004365:Drugs, Chinese Herbal