title: The potential health and economic benefits of preventing recurrent respiratory papillomatosis through quadrivalent human papillomavirus vaccination.
abstract: We estimated the health and economic benefits of preventing recurrent respiratory papillomatosis (RRP) through quadrivalent human papillomavirus (HPV) vaccination. We applied a simple mathematical model to estimate the averted costs and quality-adjusted life years (QALYs) saved by preventing RRP in children whose mothers had been vaccinated at age 12 years. Under base case assumptions, the prevention of RRP would avert an estimated USD 31 (range: USD 2-178) in medical costs (2006 US dollars) and save 0.00016 QALYs (range: 0.00001-0.00152) per 12-year-old girl vaccinated. Including the benefits of RRP reduced the estimated cost per QALY gained by HPV vaccination by roughly 14-21% in the base case and by <2% to >100% in the sensitivity analyses. More precise estimates of the incidence of RRP are needed, however, to quantify this impact more reliably.
authors.affiliation: Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA. HChesson@cdc.gov
authors.forename: Harrell W
authors.initials: HW
authors.lastname: Chesson
authors.forename: Sara E
authors.initials: SE
authors.lastname: Forhan
authors.forename: Sami L
authors.initials: SL
authors.lastname: Gottlieb
authors.forename: Lauri E
authors.initials: LE
authors.lastname: Markowitz
mesh_terms: D000293:Adolescent; D000328:Adult; D019496:Cancer Vaccines / Q000191:economics* / Q000276:immunology; D002648:Child; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D008962:Models, Theoretical; D009364:Neoplasm Recurrence, Local / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control*; D010212:Papilloma / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control*; D019057:Quality-Adjusted Life Years; D012142:Respiratory Tract Neoplasms / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control*; D014611:Vaccination / Q000191:economics*
chemical_list: D019496:Cancer Vaccines