title: Modularity in the genetic disease-phenotype network.
abstract: Similar disease phenotypes are engendered as a result of the modular nature of gene networks; thus we hypothesized that all human genetic disease phenotypes appear in similar modular styles. Network representations of phenotypes make it possible to explore this hypothesis. We investigated the modularity of a network of genetic disease phenotypes. We computationally extracted phenotype modules and found that the modularity is well correlated with a physiological classification of human diseases. We also found correlations between the modularity and functional genomics as well as its connection to drug-target associations.
authors.affiliation: National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, PR China.
authors.forename: Xingpeng
authors.initials: X
authors.lastname: Jiang
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Jiefeng
authors.initials: J
authors.lastname: Jiang
authors.forename: Huizhi
authors.initials: H
authors.lastname: Zhao
authors.forename: Ming
authors.initials: M
authors.lastname: Fan
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhenjie
authors.initials: Z
authors.lastname: Fan
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
mesh_terms: D053263:Gene Regulatory Networks; D030342:Genetic Diseases, Inborn / Q000145:classification* / Q000235:genetics*; D023281:Genomics; D005838:Genotype; D006801:Humans; D010641:Phenotype