title: Toward patient-specific myocardial models of the heart.
abstract: This article presents a framework for building patient-specific models of the myocardium, to help diagnosis, therapy planning, and procedure guidance. The aim is to be able to introduce such models in clinical applications. Thus, there is a need to design models that can be adjusted from clinical data, images, or signals, which are sparse and noisy. The authors describe the three main components of a myocardial model: the anatomy, the electrophysiology, and the biomechanics. For each of these components, the authors try to obtain the best balance between prior knowledge and observable parameters to be able to adjust these models to patient data. To achieve this, there is a need to design models with the right level of complexity and a computational cost compatible with clinical constraints.
authors.affiliation: Institut National de Recherche en Informatique et en Automatique, Sophia Antipolis, France. maxime.sermesant@inria.fr
authors.forename: Maxime
authors.initials: M
authors.lastname: Sermesant
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Peyrat
authors.forename: Phani
authors.initials: P
authors.lastname: Chinchapatnam
authors.forename: Florence
authors.initials: F
authors.lastname: Billet
authors.forename: Tommaso
authors.initials: T
authors.lastname: Mansi
authors.forename: Kawal
authors.initials: K
authors.lastname: Rhode
authors.forename: Hervé
authors.initials: H
authors.lastname: Delingette
authors.forename: Reza
authors.initials: R
authors.lastname: Razavi
authors.forename: Nicholas
authors.initials: N
authors.lastname: Ayache
mesh_terms: D000818:Animals; D054849:Cardiac Electrophysiology; D004285:Dogs; D006321:Heart / Q000033:anatomy & histology* / Q000294:innervation / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D009206:Myocardium