title: In situ synthesis of hybrid nanocomposite with highly order arranged amorphous metallic copper nanoparticle in poly(2-hydroxyethyl methacrylate) and its potential for blood-contact uses.
abstract: A hybrid consisting of a highly ordered nanostructure of metallic Cu(0) nanoparticles embedded in a poly(2-hydroxyethyl methacrylate) (pHEMA) matrix was successfully synthesized by in situ photopolymerization, followed by in situ chemical reduction. The evolution of an ordered nanostructure of Cu(0) showing a nearly amorphous nature is discussed, and it is proposed that it is due to a coupling interaction between the Cu precursor and the unpaired O of the COOR group, associated with water molecules, among pHEMA molecules. The hybrids showed a negative surface charge and considerable improvement in blood compatibility compared to neat pHEMA and the widely used biomaterial polysulfonate.
authors.affiliation: Department of Materials Science and Engineering, National Chiao Tung University, 1001 Ta-hsueh Road, Hsinchu, Taiwan.
authors.forename: Yen-Yu
authors.initials: YY
authors.lastname: Liu
authors.forename: Dean-Mo
authors.initials: DM
authors.lastname: Liu
authors.forename: San-Yuan
authors.initials: SY
authors.lastname: Chen
authors.forename: Tsan-Hua
authors.initials: TH
authors.lastname: Tung
authors.forename: Tse-Ying
authors.initials: TY
authors.lastname: Liu
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry; D001769:Blood / Q000378:metabolism; D003300:Copper / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D008670:Metals; D008689:Methacrylates; D013451:Sulfonic Acids; D011102:Polyhydroxyethyl Methacrylate; C005044:hydroxyethyl methacrylate; D003300:Copper; D010100:Oxygen