title: Modeling of nociceptor transduction in skin thermal pain sensation.
abstract: All biological bodies live in a thermal environment with the human body as no exception, where skin is the interface with protecting function. When the temperature moves out of normal physiological range, skin fails to protect and pain sensation is evocated. Skin thermal pain is one of the most common problems for humans in everyday life as well as in thermal therapeutic treatments. Nocicetors (special receptor for pain) in skin play an important role in this process, converting the energy from external noxious thermal stimulus into electrical energy via nerve impulses. However, the underlying mechanisms of nociceptors are poorly understood and there have been limited efforts to model the transduction process. In this paper, a model of nociceptor transduction in skin thermal pain is developed in order to build direct relationship between stimuli and neural response, which incorporates a skin thermomechanical model for the calculation of temperature, damage and thermal stress at the location of nociceptor and a revised Hodgkin-Huxley form model for frequency modulation. The model qualitatively reproduces measured relationship between spike rate and temperature. With the addition of chemical and mechanical components, the model can reproduce the continuing perception of pain after temperature has returned to normal. The model can also predict differences in nociceptor activity as a function of nociceptor depth in skin tissue.
authors.affiliation: Engineering Department, Cambridge University, Cambridge CB2 1PZ, UK.
authors.forename: F
authors.initials: F
authors.lastname: Xu
authors.forename: T
authors.initials: T
authors.lastname: Wen
authors.forename: T J
authors.initials: TJ
authors.lastname: Lu
authors.forename: K A
authors.initials: KA
authors.lastname: Seffen
mesh_terms: D003198:Computer Simulation; D006358:Hot Temperature; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology*; D040542:Mechanotransduction, Cellular; D008954:Models, Biological; D009619:Nociceptors / Q000503:physiopathology*; D017288:Pain Threshold; D012867:Skin / Q000503:physiopathology*