Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis.
Reactive oxygen species (ROS) are implicated in the pathogenesis of multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). The effect of edaravone, a free radical scavenger, on EAE was investigated in this study. Treatment with edaravone significantly ameliorated the clinical severity of EAE, and a reduced infiltration of lymphocytes was observed based on a histological analysis. The expression of inducible NO synthase (iNOS) in the spinal cords appeared to be reduced by the treatment with edaravone and this effect was confirmed in vitro. A reduction of both the cellular infiltration and the expression of iNOS may therefore underlie the mechanisms of the beneficial effect of edaravone on EAE.
Moriya
Masayuki
M
Department of Neurology (D-4), Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.
Nakatsuji
Yuji
Y
Miyamoto
Katsuichi
K
Okuno
Tatsusada
T
Kinoshita
Makoto
M
Kumanogoh
Atsushi
A
Kusunoki
Susumu
S
Sakoda
Saburo
S
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017252:CD3 Complex / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002461:Cell Line, Transformed; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects; D000077553:Edaravone; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D051379:Mice; D008840:Microfilament Proteins; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D013116:Spinal Cord / Q000187:drug effects / Q000201:enzymology; D018709:Statistics, Nonparametric
C491049:Aif1 protein, mouse; D017252:CD3 Complex; D002135:Calcium-Binding Proteins; D016166:Free Radical Scavengers; D008840:Microfilament Proteins; D052247:Nitric Oxide Synthase Type II; D000077553:Edaravone; D000983:Antipyrine