title: Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition.
abstract: A versatile synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxylate esters has been developed which has lead to the identification of a new series of non-nucleoside inhibitors of human herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.
authors.affiliation: Global Research and Development, Pfizer Inc., 700 Chesterfield Parkway West, St. Louis, MO 63017, USA. mark.e.schnute@pfizer.com
authors.forename: Mark E
authors.initials: ME
authors.lastname: Schnute
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Brideau
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Collier
authors.forename: Michele M
authors.initials: MM
authors.lastname: Cudahy
authors.forename: Todd A
authors.initials: TA
authors.lastname: Hopkins
authors.forename: Mary L
authors.initials: ML
authors.lastname: Knechtel
authors.forename: Nancee L
authors.initials: NL
authors.lastname: Oien
authors.forename: Robert S
authors.initials: RS
authors.lastname: Sackett
authors.forename: Allen
authors.initials: A
authors.lastname: Scott
authors.forename: Mari L
authors.initials: ML
authors.lastname: Stephan
authors.forename: Michael W
authors.initials: MW
authors.lastname: Wathen
authors.forename: Janet L
authors.initials: JL
authors.lastname: Wieber
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003587:Cytomegalovirus / Q000201:enzymology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D004952:Esters; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D006564:Herpesviridae / Q000187:drug effects*; D014645:Herpesvirus 3, Human / Q000201:enzymology; D004854:Herpesvirus 4, Human / Q000201:enzymology; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D008968:Molecular Conformation; D019384:Nucleic Acid Synthesis Inhibitors; D011728:Pyridones / Q000138:chemical synthesis* / Q000494:pharmacology; D018139:Simplexvirus / Q000201:enzymology
chemical_list: C532910:4-oxo-4,7-dihydrofuro(2,3-b)pyridine-5-carboxamide; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D004952:Esters; D005663:Furans; D019384:Nucleic Acid Synthesis Inhibitors; D011728:Pyridones