title: Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms.
abstract: Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. Self-emulsifying drug delivery systems (SEDDS) are usually used to improve the bioavailability of hydrophobic drugs. Conventional SEDDS, however, are mostly prepared in a liquid form, which can produce some disadvantages. Accordingly, solid SEDDS (S-SEDDS), prepared by solidification of liquid/semisolid self-emulsifying (SE) ingredients into powders, have gained popularity. This article gives an overview of the recent advances in the study of S-SEDDS, especially the related solidification techniques and the development of solid SE dosage forms. Finally, the existing problems and the possible future research directions in this field are pointed out.
authors.affiliation: Shenyang Pharmaceutical University, Shenyang City 110016, Liaoning Province, People's Republic of China. tangbobox@126.com
authors.forename: Bo
authors.initials: B
authors.lastname: Tang
authors.forename: Gang
authors.initials: G
authors.lastname: Cheng
authors.forename: Jian-Chun
authors.initials: JC
authors.lastname: Gu
authors.forename: Cai-Hong
authors.initials: CH
authors.lastname: Xu
mesh_terms: D000818:Animals; D001702:Biopharmaceutics; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D016503:Drug Delivery Systems; D004655:Emulsions; D006801:Humans
chemical_list: D004304:Dosage Forms; D004655:Emulsions