[Apolipoprotein A5 gene: association with triglyceride metabolism and cardiovascular disease].
Hypertriglyceridemia constitutes an independent risk factor for coronary disease. The gene apolipoprotein A5 (ApoA5) is a newly discovered member in the ApoA1/C3/A4/A5 cluster, and its product, apolipoprotein A5, influences on triglycerides through an unknown mechanism. Recently, there have been described the clinical consequences and the functional effects over more than 10 variants of the ApoA5 gene, associated with atherosclerosis. In different studies carried out in different ethnic groups, it has been observed a great variation in the distribution of the ApoA5 genotypes for the respective polymorphisms. Different authors have described associations among the ApoA5 gene, high triglyceride concentrations and an increase in the cardiovascular risk. In this context, the ApoA5 gene is considered as a probable biochemical and genetic marker of increased triglyceride concentrations and also a risk factor of coronary disease in some populations.
Oliveira Sousa
Marinez
M
Departamento de Análises Clínicas e Toxicológicas, Facultade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. marinez@farmacia.ufmg.br
Alía
Pedro
P
Pintó
Xavier
X
D000483:Alleles; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D015228:Hypertriglyceridemia / Q000235:genetics; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000378:metabolism*
C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D014280:Triglycerides