Budesonide for local therapy of complex oral mucosal immune-mediated inflammatory diseases: case reports.
Local immunosuppressive therapies without systemic effects represent a therapeutic advantage in management of immune/inflammatory oral mucosal conditions. Topical budesonide rinses were prescribed to patients with mucosal disease that was resistant to other intervention without side effects. A case of paraneoplastic pemphigus and a patient with oral graft-versus-host disease that had not responded to standard approaches to management were successfully managed with budesonide rinse application. The cases presented represent mucosal conditions that were successfully managed with topical application of budesonide with reduced risk of systemic effects.
Utsman
Robert A
RA
Department of Oral Medicine and Diagnostic Sciences, University of Illinois at Chicago, College of Dentistry, Chicago, IL 60612, USA.
Epstein
Joel B
JB
Elad
Sharon
S
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D019819:Budesonide / Q000627:therapeutic use*; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007945:Leukemia, Lymphoid / Q000150:complications; D008224:Lymphoma, Follicular / Q000150:complications; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D009061:Mouth Mucosa / Q000276:immunology; D009067:Mouthwashes / Q000627:therapeutic use; D009078:Mucocele / Q000209:etiology; D020556:Neutrophil Infiltration; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D010392:Pemphigus / Q000150:complications / Q000188:drug therapy* / Q000209:etiology
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D009067:Mouthwashes; D019819:Budesonide