title: Antibodies and immunohistochemical evaluation for the diagnosis of hematological malignancies: an overview.
abstract: The immunohistochemical evaluation of hematopoietic tissues has expanded our knowledge of both the function and pathological processes in a wide range of lymph nodal, extranodal tissues, and bone marrow. It is impossible to cover in detail the full range of immunohistochemical markers, which are available to study hematopoietic cells and their malignant counterparts. This chapter attempts to provide an overview of the antibodies, which are commonly used in studying the hematopoietic and lymphoid tissues and to diagnose hematological disorders. In addition, an immunohistology-based diagnostic approach to identify specific neoplastic entities is described in some length.
authors.affiliation: Department of Pathology, Indiana School of Medicine, Indianapolis, IN, USA.
authors.forename: Dennis P
authors.initials: DP
authors.lastname: O'Malley
authors.forename: Attilio
authors.initials: A
authors.lastname: Orazi
mesh_terms: D000912:Antibodies, Neoplasm / Q000276:immunology*; D001854:Bone Marrow Cells / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D006098:Granulocytes / Q000166:cytology / Q000276:immunology / Q000473:pathology; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007938:Leukemia / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D008223:Lymphoma / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D008533:Megakaryocytes / Q000166:cytology / Q000276:immunology / Q000473:pathology; D009000:Monocytes / Q000166:cytology / Q000276:immunology / Q000473:pathology; D009195:Peroxidase / Q000032:analysis
chemical_list: D000912:Antibodies, Neoplasm; D009195:Peroxidase