Hair follicle epithelial stem cells get their sox on.
Sox family transcription factors have emerged as key regulators of multiple developmental processes, including fate determination and differentiation in multiple tissues. In this issue of Cell Stem Cell, Nowak et al. (2008) implicate Sox9 in the specification of early hair follicle stem cells and subsequent epithelial lineages.
Christiano
Angela M
AM
Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, NY 10032, USA. amc65@columbia.edu
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology*; D018859:Hair Follicle / Q000166:cytology* / Q000502:physiology*; D006609:High Mobility Group Proteins / Q000378:metabolism* / Q000502:physiology; D015603:Keratinocytes / Q000502:physiology; D051379:Mice; D055758:SOX9 Transcription Factor; D051876:Sex-Determining Region Y Protein / Q000378:metabolism; D013234:Stem Cells / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism* / Q000502:physiology
D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D055758:SOX9 Transcription Factor; D051876:Sex-Determining Region Y Protein; C527933:Sox9 protein, mouse; D014157:Transcription Factors