title: Novel neutral imidazole-lipophosphoramides for transfection assays.
abstract: New helper lipids, possessing an imidazole polar head, have been synthesized and included in formulations for transfection assays; these new helper lipids can improve the transfection by a factor of up to 100 compared to the use of DOPE as co-lipid.
authors.affiliation: CEMCA, UMR CNRS 6521, Université de Bretagne Occidentale, CNRS UMR 6521, 6 Avenue Le Gorgeu, 29238 Brest, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Mével
authors.forename: Cécile
authors.initials: C
authors.lastname: Neveu
authors.forename: Cristine
authors.initials: C
authors.lastname: Gonçalves
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Yaouanc
authors.forename: Chantal
authors.initials: C
authors.lastname: Pichon
authors.forename: Paul-Alain
authors.initials: PA
authors.lastname: Jaffrès
authors.forename: Patrick
authors.initials: P
authors.lastname: Midoux
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D002460:Cell Line; D015195:Drug Design; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000378:metabolism; D063088:Phosphoramides; D010756:Phosphoric Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D014162:Transfection / Q000379:methods*
chemical_list: C410262:1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine; D000577:Amides; D007093:Imidazoles; D008051:Lipid Bilayers; D010714:Phosphatidylethanolamines; D063088:Phosphoramides; D010756:Phosphoric Acids; C005438:phosphoramide