Porcine myelomonocytic markers and cell populations.
This review focuses in what is currently known about swine myeloid markers, the expression and function of these receptors in the biology of porcine myelomonocytic cells, the regulation of their expression along the different developmental stages of these cells and their utility to investigate the heterogeneity of monocyte and macrophage populations. Although the number of monoclonal antibodies recognizing surface antigens expressed on either swine granulocytes or monocytes is low compared with those available for human or mouse, they have contributed significantly to study the members of myeloid lineages in this species, allowing to discriminate different maturation stages of these cells in bone marrow and to reveal the heterogeneity of blood monocytes and tissue macrophages. Porcine myeloid cells share many similarities with humans, highlighting the relevance of the pig as a biomedical model.
Ezquerra
A
A
Departamento de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra de La Coruña, km 7.5, 28040 Madrid, Spain.
Revilla
C
C
Alvarez
B
B
Pérez
C
C
Alonso
F
F
Domínguez
J
J
D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D000943:Antigens, Differentiation / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D002454:Cell Differentiation; D019070:Cell Lineage / Q000235:genetics / Q000276:immunology; D004266:DNA Virus Infections / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D018507:Gene Expression Regulation, Developmental; D022423:Myeloid Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D038042:Myelopoiesis / Q000235:genetics / Q000276:immunology; D040901:Proteomics; D013552:Swine / Q000276:immunology*
D015703:Antigens, CD; D000943:Antigens, Differentiation