Critical roles for c-Myb in hematopoietic progenitor cells.
While it has long been known that the transcription factor c-Myb is an essential regulator of hematopoiesis, its precise molecular targets have remained elusive. Cell line studies suggest that c-Myb promotes proliferation and at the same time inhibits differentiation, however the early lethality of c-Myb deficient embryos precluded analysis of its role in adult hematopoiesis. Here we review insights derived from recently developed mouse models of c-Myb deficiency that are viable as adults. These studies reveal a complex array of functions for c-Myb in multiple hematopoietic cell types that will redefine our understanding of this crucial transcription factor.
Greig
Kylie T
KT
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia. kylieg@wehi.edu.au
Carotta
Sebastian
S
Nutt
Stephen L
SL
D000818:Animals; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D020598:Proto-Oncogene Proteins c-myb / Q000502:physiology*
D020598:Proto-Oncogene Proteins c-myb