title: Role of plasma proteins in pharmacokinetics of micafungin, an antifungal antibiotic, in analbuminemic rats.
abstract: There were no significant differences in the pharmacokinetics of micafungin and expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2) between analbuminemic and Sprague-Dawley rats. Micafungin bound strongly to high-density lipoprotein (HDL) and moderately to gamma globulin. These results suggest that HDL and gamma globulin contribute to the pharmacokinetics of micafungin.
authors.affiliation: Department of Pharmacy and Pharmacokinetics, Aichi Medical University School of Medicine, Nagakute-cho, Aichi-gun, Aichi, Japan.
authors.forename: Fumie
authors.initials: F
authors.lastname: Abe
authors.forename: Jun
authors.initials: J
authors.lastname: Ueyama
authors.forename: Noriyo
authors.initials: N
authors.lastname: Kawasumi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nadai
authors.forename: Tamon
authors.initials: T
authors.lastname: Hayashi
authors.forename: Miki
authors.initials: M
authors.lastname: Kato
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ohnishi
authors.forename: Hiroko
authors.initials: H
authors.lastname: Saito
authors.forename: Naoshi
authors.initials: N
authors.lastname: Takeyama
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hasegawa
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D001798:Blood Proteins / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000378:metabolism; D054714:Echinocandins / Q000493:pharmacokinetics*; D055666:Lipopeptides; D008074:Lipoproteins / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D000077551:Micafungin; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000172:deficiency* / Q000378:metabolism; D005719:gamma-Globulins / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D001798:Blood Proteins; D008076:Cholesterol, HDL; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D000077551:Micafungin; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D012709:Serum Albumin; D005719:gamma-Globulins