Effects of brain-derived neurotrophic factor-catecholamine-O-methyltransferase gene interaction on schizophrenic symptoms.
The methionine variant of Val66Met brain-derived neurotrophic factor BDNF met and catecholamine-O-methyltransferase (COMT L) is associated with a deficit in attention and aggravation of delusions in schizophrenia. We hypothesized that the BDNF-COMT gene interaction would affect the symptoms and cognition in schizophrenia. Ninety-six schizophrenic patients and 79 control participants were recruited. The patients who were BDNF met/met x COMT L carriers had the highest scores of delusion of Positive Symptoms and the Scale for Assessment of Negative Symptoms, word reading of the color word test, and trail-making test B time, compared with the other three genotype interactions. The current results suggest that patients with the BDNF met/met x COMT L allele had more delusional symptoms and poorer cognitive flexibility, compared with the other three genotype interactions.
Han
Doug Hyun
DH
Department of Psychiatry College of Medicine, Daegu Catholic University, Daegu, Seoul, South Korea.
Park
Doo Byung
DB
Choi
Tae Young
TY
Joo
So Youn
SY
Lee
Mi Kyung
MK
Park
Bo Rae G
BR
Nishimura
Ryoji
R
Chu
Chung-Chou
CC
Renshaw
Perry F
PF
D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology; D003702:Delusions / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000523:psychology; D005820:Genetic Testing / Q000706:statistics & numerical data; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D014936:Word Association Tests / Q000706:statistics & numerical data
D019208:Brain-Derived Neurotrophic Factor; D002394:Catechol O-Methyltransferase