title: Trigeminal trophic syndrome with features of oral CMV disease.
abstract: Trigeminal trophic syndrome (TTS) is an exceedingly rare complication following injury to the trigeminal ganglion, characterized by painless ulcerations, which has only rarely been reported with intraoral features. We present a patient with multiple intraoral ulcerations of the right buccal and alveolar mucosa that had previously been treated with nerve ablation therapy for trigeminal neuralgia. Positive immunohistochemistry staining of a biopsy specimen for cytomegalovirus suggested a viral etiology; however, lesions persisted despite antiviral therapy, and immunohistochemistry was negative on follow-up biopsy. Diagnosis of TTS is one of exclusion as it can mimic many other conditions, and should be considered in patients with unilateral painless ulcerations with a history of trigeminal nerve damage.
authors.affiliation: School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Ramin Mostofi Zadeh
authors.initials: RM
authors.lastname: Farahani
authors.forename: Derek K
authors.initials: DK
authors.lastname: Marsee
authors.forename: Lindsey R
authors.initials: LR
authors.lastname: Baden
authors.forename: Sook-Bin
authors.initials: SB
authors.lastname: Woo
authors.forename: Nathaniel S
authors.initials: NS
authors.lastname: Treister
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D008297:Male; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D019226:Oral Ulcer / Q000209:etiology*; D013577:Syndrome; D012668:Trigeminal Ganglion / Q000293:injuries*; D020433:Trigeminal Nerve Diseases / Q000175:diagnosis / Q000209:etiology*; D014277:Trigeminal Neuralgia / Q000601:surgery
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir