title: Cystatin C-based equations in renal transplantation: moving toward a better glomerular filtration rate prediction?
abstract: Creatinine-based glomerular filtration rate (GFR) estimators perform poorly in renal transplant recipients. Cystatin C might be a better alternative to serum creatinine in assessing renal graft function. We compared several cystatin C-based equations with the modification diet renal disease (MDRD) equation in 120 adult renal transplant recipients for whom the GFR was measured by the gold standard inulin clearance. Mean inulin-measured GFR was 52.6 mL/min/1.73 m (range, 13-119). The Hoek, Rule, Le Bricon, and Filler cystatin C-based formulas showed significantly better performances (accuracy 30% of 82%, 81%, 78%, and 71%), than the MDRD equation (58%, Mac Nemar test, P<0.01). Sensitivity to detect a GFR below 60 mL/min/1.73 m was significantly higher for the Hoek and the Rule equations (0.95, 95% CI 0.91-1) than for the MDRD equation (0.76, 95% CI 0.67-0.85). These data confirm that cystatin C as a GFR marker offers significant advantages over creatinine in renal transplantation.
authors.affiliation: Service de Néphrologie, Dialyse, Transplantation Rénale, Laboratoires d'Explorations Fonctionnelles Rénales, Saint-Etienne, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Maillard
authors.forename: Christophe
authors.initials: C
authors.lastname: Mariat
authors.forename: Christine
authors.initials: C
authors.lastname: Bonneau
authors.forename: Manolie
authors.initials: M
authors.lastname: Mehdi
authors.forename: Lise
authors.initials: L
authors.lastname: Thibaudin
authors.forename: Silvy
authors.initials: S
authors.lastname: Laporte
authors.forename: Eric
authors.initials: E
authors.lastname: Alamartine
authors.forename: Annette
authors.initials: A
authors.lastname: Chamson
authors.forename: François
authors.initials: F
authors.lastname: Berthoux
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007444:Inulin / Q000378:metabolism; D007668:Kidney / Q000502:physiology; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D007444:Inulin; D003404:Creatinine