title: A case of a patient with both chorea and restless legs syndrome.
abstract: The patient was a 44-yr-old man with end-stage renal disease who had developed chorea as a result of hypoglycemic injury to the basal ganglia and thalamus and who was subsequently diagnosed with depression and restless legs syndrome (RLS). For proper management, the presence of a complex medical condition including two contrasting diseases, chorea and RLS, had to be considered. Tramadol improved the pain and dysesthetic restlessness in his feet and legs, and this was gradually followed by improvements in his depressed mood, insomnia, lethargy, and feelings of hopelessness. This case suggests that the dopaminergic system participates intricately with the opioid, serotoninergic, and noradrenergic systems in the pathophysiology of RLS and pain and indirectly of depression and insomnia.
authors.affiliation: Department of Psychiatry, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea.
authors.forename: Yoon-Kyung
authors.initials: YK
authors.lastname: Shin
authors.forename: Seung-Chul
authors.initials: SC
authors.lastname: Hong
authors.forename: Yon Kwon
authors.initials: YK
authors.lastname: Ihn
authors.forename: Jong-Hyun
authors.initials: JH
authors.lastname: Jeong
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Han
authors.forename: Sung-Pil
authors.initials: SP
authors.lastname: Lee
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000627:therapeutic use; D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use; D002819:Chorea / Q000150:complications* / Q000473:pathology; D015283:Citalopram / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D012148:Restless Legs Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D014147:Tramadol / Q000627:therapeutic use
chemical_list: D000701:Analgesics, Opioid; D018726:Anti-Dyskinesia Agents; D015283:Citalopram; D006220:Haloperidol; D017367:Selective Serotonin Reuptake Inhibitors; D014147:Tramadol