Enantioselective Transaminations by Dendrimeric Enzyme Mimics.
PAMAM dendrimers have been constructed with a pyridoxamine core, and chiral capping amino groups. Transamination to form phenylalanine and alanine from their related ketoacids produced enantioselectivities induced by the formally remote chiral caps, supporting computer models that indicate folding of the dendrimer chains back into the core region.
Breslow
Ronald
R
Department of Chemistry, Columbia University, New York NY 10027.
Wei
Sujun
S
Kenesky
Craig
C