[The multifunctionality of CHIP protein in the protein quality-control system].
Selective protein degradation depends on their quality being controlled by the cellular system, which includes chaperones involved in protein folding and two degradation systems, the proteasomal and lysosomal. CHIP (carboxyl terminus of Hsp70-interacting protein), an E3 ubiquitin ligase and co-chaperone, serves as a chaperone-degradation system interface. This article reviews the molecular characteristics of CHIP protein, the mechanism of its action, and its role in cellular metabolism and discusses how CHIP dysfunction may lead to neurodegenerative diseases.
Lenartowski
Robert
R
Instytut Biologii Ogólnej i Molekularnej, Zakład Genetyki, Uniwersytet Mikołaja Kopernika w Toruniu, Toruń. rlenart@umk.pl <rlenart@umk.pl>
Gumowski
Krzysztof
K
Goc
Anna
A
D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
C467728:STUB1 protein, human; D044767:Ubiquitin-Protein Ligases