title: Inhibition of developmental processes by flavone in Caenorhabditis elegans and its application to the pinewood nematode, Bursaphelenchus xylophilus.
abstract: Flavone (2-phenyl chromone) is a well-known plant flavonoid, but its bioactivity has been little explored. Treatment of Caenorhabditis elegans or C. brissage with flavones induced embryonic and larval lethality that was pronounced in early larval stages. This anti-nematodal effect was also observed in the pinewood nematode, B. xylophilus. LD(50) values were approximately 100 muM for both B. xylophilus and C. elegans. Our results indicate that flavone is an active nematicidal compound that should be further investigated with the aim of developing a potent drug against B. xylophilus.
authors.affiliation: Department of Bioscience and Biotechnology, and Bio/Molecular Informatics Center, Konkuk University, Seoul 143-701, Korea.
authors.forename: Yong-Uk
authors.initials: YU
authors.lastname: Lee
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kawasaki
authors.forename: Yoongho
authors.initials: Y
authors.lastname: Lim
authors.forename: Wan-Suk
authors.initials: WS
authors.lastname: Oh
authors.forename: Young-Ki
authors.initials: YK
authors.lastname: Paik
authors.forename: Yhong-Hee
authors.initials: YH
authors.lastname: Shim
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000254:growth & development*; D047309:Flavones; D005419:Flavonoids / Q000494:pharmacology*; D009348:Nematoda / Q000187:drug effects*
chemical_list: D000969:Antinematodal Agents; D047309:Flavones; D005419:Flavonoids; C043562:flavone