title: The macrokinetic behavior of an enzymatic system with an enzyme inactivated in the reaction.
abstract: This study deals with the behavior of a heterogeneous multisubstrate enzymatic system under enzyme inactivation in a reaction. Electronic computer modeling data have been obtained for its macrokinetics at different modes: (1) under mixed inflow of the substrates and (2) under their spatial separation. The enzymatic membrane exhibits low sensitivity to a change in the external conditions as the substrates are intermixed on the boundary. Quite the contrary, in the case of spatial separation of the substrates, the product flow from the membrane has displayed abrupt fluctuations at different boundary conditions. This work also looks into the arrangement of the reaction zones in the membrane and their transitions under different conditions.
authors.affiliation: Moscow State University, Moscow 119899, USSR.
authors.forename: G F
authors.initials: GF
authors.lastname: Sud'ina
authors.forename: G M
authors.initials: GM
authors.lastname: Kobel'kov
authors.forename: S D
authors.initials: SD
authors.lastname: Varfolomeev