title: [Liver histopathology, clinical features and prognostic factors of primary biliary cirrhosis: an analysis of 60 cases].
abstract: OBJECTIVE
  Clinical and liver pathological features of 60 primary biliary cirrhosis (PBC) patients were reviewed to identify prognostic factors in order to improve the diagnosis and treatment of the disease.
  
  
  METHODS
  The general conditions, clinical manifestations, serum biochemical and immunological changes, and liver pathological findings were assessed in 60 PBC patients. All cases were followed up and 5 variables were studied by univariate analysis; the variables linked with survival were included in a Cox model.
  
  
  RESULTS
  Forty-eight patients were females (80%), 12 were males (20%), and the mean age at their diagnoses was (52.5+/-9.4). The symptoms most frequently complained about were jaundice (61.6%), fatigue (51.6%), anorexia (43.3%) and pruritus (25%). Serum alkaline phosphatase (ALP) and glutamyl transpeptidase (GGT) levels were markedly elevated in the majority of the patients [(242.3+/-137.1) U/L and (250.6+/-216.1) U/L, respectively], whereas ALT and AST levels were mildly to moderately elevated [(185.8+/-269.1) U/L and (172.5+/-163.6) U/L, respectively]. Thirty-two patients (53.3%) had a total bilirubin level of > or = 34.2 micromol/L. Twenty-eight patients (59.5%) had elevated serum IgM and 41 patients (68.3%) were anti-mitochondrial antibody AMA/AMA-M2 positive. Forty-two of the 60 patients had liver biopsies. The liver pathological changes: 33.3% of the cases were in I or II stage and 66.6% in III or IV stage. The follow up results: Five patients died of liver failure or massive upper gastrointestinal bleeding; 45 were still alive; the average survival period was 3.92 years; 10 patients were lost in the follow-up. With multivariate analysis (Cox model), age, level of total bilirubin and the stage of the liver pathological changes were found to be independent factors linked to the survival of the patients.
  
  
  CONCLUSIONS
  PBC may not be a rare liver disease in China. The awareness to recognize PBC is important in making an early diagnosis and treatment.
authors.affiliation: Department of Gastroenterology, Yan'an Hospital of Kunming, Kunming 650051, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yao
authors.forename: Zhi-yuan
authors.initials: ZY
authors.lastname: Xu
authors.forename: Jian-peng
authors.initials: JP
authors.lastname: Gao
authors.forename: Xue-ping
authors.initials: XP
authors.lastname: Chen
authors.forename: Li-juan
authors.initials: LJ
authors.lastname: Shen
authors.forename: Li-hong
authors.initials: LH
authors.lastname: Yang
authors.forename: Li-ying
authors.initials: LY
authors.lastname: You
authors.forename: Jin-hui
authors.initials: JH
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult