title: Sesquiterpene lactone dermatitis in the young: is atopy a risk factor?
abstract: Screening for Compositae contact allergy has documented fairly high prevalence in adults, and recent studies indicate that the allergy may be more common in children than previously believed. However, detailed information on sensitization in this age group is sparse. The objective of this study was to present another 2 cases in children and review the literature. Screening with sesquiterpene lactone (SL) mix has shown prevalence of 0.5% and 1.8% in 2 studies, while screening with 2 different Compositae mixes detected 4.2% and 2.6% positives among children and adolescents. All individual case reports describe sensitization in atopic children, and the largest screening study showed a prevalence of Compositae mix sensitization that was significantly higher in children with atopic dermatitis compared with non-atopics. Compositae sensitization should be considered in children with a family or personal history of atopy, summer-related, or -exacerbated dermatitis of any kind, and a history of plant exposure. Screening with SL mix is recommended but should be supplemented with plant extracts based on exposure history. Compositae weeds, especially dandelions, seem to be important sensitizers in children.
authors.affiliation: Department of Dermatology, Odense University Hospital, University of Southern Denmark, DK-5000 Odense C, Denmark. evy.paulsen@ouh.regionsyddanmark.dk
authors.forename: Evy
authors.initials: E
authors.lastname: Paulsen
authors.forename: Aksel
authors.initials: A
authors.lastname: Otkjaer
authors.forename: Klaus E
authors.initials: KE
authors.lastname: Andersen
mesh_terms: D000293:Adolescent; D000328:Adult; D019659:Asteraceae / Q000009:adverse effects* / Q000737:chemistry; D002648:Child; D002675:Child, Preschool; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D003876:Dermatitis, Atopic / Q000150:complications*; D005260:Female; D006801:Humans; D007783:Lactones / Q000009:adverse effects*; D008297:Male; D010328:Patch Tests / Q000379:methods; D010936:Plant Extracts / Q000009:adverse effects; D015995:Prevalence; D012307:Risk Factors; D012717:Sesquiterpenes / Q000009:adverse effects*; D031205:Taraxacum / Q000009:adverse effects
chemical_list: D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes