Are pharmaceutics really going supercritical?
The present work focuses on some applications of supercritical fluids in the pharmaceutical field, provides a critical review of the most recent advances and aims to give a vision on the future of this technology. In particular, processes such as particle and crystal engineering, formation of cyclodextrin complexes, coating, foaming and tissue engineering, extrusion, production of liposomes, formulation of biotechnological compounds, sterilization and solvent removal are described and discussed.
Pasquali
Irene
I
Department of Pharmacy, University of Parma, 43100 Parma, Italy.
Bettini
Ruggero
R
D001688:Biological Products / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D025924:Chromatography, Supercritical Fluid / Q000379:methods; D003505:Cyclodextrins / Q000737:chemistry; D008081:Liposomes; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013242:Sterilization / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods*
D001688:Biological Products; D003505:Cyclodextrins; D008081:Liposomes; D004364:Pharmaceutical Preparations; D012997:Solvents