Estrogen receptor beta agonists in neurobehavioral investigations.
Neurobehavioral investigations into the functions of estrogen receptor (ER)alpha and ERbeta have utilized 'knockout' mice, phytoestrogens and, more recently, ER-specific agonists. Feeding, sexual, aggressive and social behavior, anxiety, depression, drug abuse, pain perception, and learning (and associated synaptic plasticity) are affected by ERalpha and ERbeta in a manner that is dependent upon the specific behavior studied, gender and developmental stage. Overall, ERalpha and ERbeta appear to function together to foster sociosexual behavior while inhibiting behaviors that, if occurring at the time of behavioral estrous, may compete with reproduction (eg, feeding). Recently developed pharmacological tools have limited selectivity and availability to the research community at large, as they are not commercially available. The development of highly selective, commercially available ERbeta-specific antagonists would greatly benefit preclinical and applied research.
Choleris
Elena
E
University of Guelph, Department of Psychology, MacKinnon Building, Guelph, Ontario, N1G 2W1, Canada. echoleri@uoguelph.ca
Clipperton
Amy E
AE
Phan
Anna
A
Kavaliers
Martin
M
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001007:Anxiety / Q000188:drug therapy / Q000523:psychology; D001519:Behavior / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D020013:Calcium Signaling / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D003712:Dendrites / Q000187:drug effects; D003866:Depressive Disorder / Q000188:drug therapy / Q000523:psychology; D004435:Eating / Q000187:drug effects; D047629:Estrogen Receptor beta / Q000819:agonists*; D006801:Humans; D007858:Learning / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects; D012725:Sexual Behavior / Q000187:drug effects; D012919:Social Behavior
D047629:Estrogen Receptor beta