title: Genetic polymorphisms of cyclooxygenase-1 (COX-1) are associated with functional dyspepsia in Japanese women.
abstract: BACKGROUND
  Prostaglandins (PGs), catalyzed from arachidonic acid by cyclooxygenase (COX), are involved in a variety of physiological processes in the stomach. COX-1 has been regarded as a constitutively expressed enzyme that generates prostaglandins for gastrointestinal integrity. We investigated the association between the potentially functional polymorphism T-1676C in the COX-1 gene promoter and functional dyspepsia (FD) in the Japanese population.
  
  
  METHODS
  The study was performed in 272 subjects (185 with no upper abdominal symptoms and 87 with FD). We employed the PCR-SSCP method to detect the gene polymorphism.
  
  
  RESULTS
  Overall, female sex had a 2-2.5-fold risk for the development of FD compared with male sex, whereas the COX-1 gene polymorphism and Helicobacter pylori infection were not associated with susceptibility to FD. However, in female subjects, -1676T allele carriers had a significantly increased risk for the development of FD (OR 2.70, 95%CI 1.04-6.99, p = 0.041), especially the epigastric pain syndrome (EPS) subgroup (OR 4.07, 95%CI 1.15-14.4, p = 0.029).
  
  
  CONCLUSIONS
  Our results provide the first evidence that the COX-1 gene polymorphism is significantly associated with the development of the EPS subgroup of FD in female subjects.
authors.affiliation: Department of Gatroenterology, Fujita Health University School of Medicine 1-98, Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan. tarisawa@fujita-hu.ac.jp
authors.forename: Tomiyasu
authors.initials: T
authors.lastname: Arisawa
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Tahara
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shibata
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Nagasaka
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Nakamura
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kamiya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujita
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yoshioka
authors.forename: Yuko
authors.initials: Y
authors.lastname: Arima
authors.forename: Masaaki
authors.initials: M
authors.lastname: Okubo
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hirata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
mesh_terms: D015746:Abdominal Pain / Q000150:complications / Q000235:genetics; D000328:Adult; D000704:Analysis of Variance; D044466:Asian People / Q000235:genetics; D051545:Cyclooxygenase 1 / Q000235:genetics*; D004415:Dyspepsia / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D016481:Helicobacter Infections / Q000150:complications* / Q000235:genetics; D016480:Helicobacter pylori; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D018807:Polymorphism, Single-Stranded Conformational; D012737:Sex Factors
chemical_list: D051545:Cyclooxygenase 1