Hypoglycemic effect of 13-membered ring thiocyclitol, a novel alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata).
A novel 13-membered ring thiocyclitol, isolated from an aqueous extract of Kothala-himbutu (Salacia reticulata), inhibited alpha-glucosidase in vitro. The inhibitory activity was investigated by maltose- and sucrose-loading on Wistar rats. This study found significant lowering of postprandial glucose levels, and the potency of 13-membered ring thiocyclitol was confirmed in vivo.
Oe
Hiromi
H
Research Institute, Fuji-Sangyo Co, Ltd, Kagawa, Japan.
Ozaki
Sei
S
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D054812:Cyclitols / Q000302:isolation & purification / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology; D008320:Maltose / Q000097:blood; D019518:Postprandial Period; D051381:Rats; D017208:Rats, Wistar; D049918:Salacia / Q000737:chemistry*; D013395:Sucrose / Q000097:blood
D001786:Blood Glucose; D054812:Cyclitols; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D013395:Sucrose; D008320:Maltose