Propindilactones E-J, Schiartane Nortriterpenoids from Schisandra propinqua var. propinqua.
Six new nortriterpenoids, propindilatones E-J (1-6), and two known (7, 8) schiartane-type nortriterpenoids were isolated from the stems of Schisandra propinqua var. propinqua. Their structures were elucidated by extensive spectroscopic analyses, and the structure of compound 4 was confirmed through single-crystal X-ray diffraction. The absolute configuration of compounds 1-3 was established using CD methods. Compounds 4-6 were noncytotoxic against K562, A549, and HT-29 human cancer cells.
Lei
Chun
C
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Huang
Sheng-Xiong
SX
Chen
Ji-Jun
JJ
Yang
Li-Bin
LB
Xiao
Wei-Lie
WL
Chang
Yin
Y
Lu
Yang
Y
Huang
Hao
H
Pu
Jian-Xin
JX
Sun
Han-Dong
HD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C512130:schiartane