title: Synthesis of bone formation deriving biosilanes.
abstract: Six silane coupling agents having amide group (biosilanes) were synthesized with the aim to construct the material surface that allows cells to be compatible with it without their destruction. These agents were expected to make a soft landing to cytoplasm through the hydrogen bonding between their amide groups and cells. Evaluations of cell affinity using glass substrates modified with the synthesized biosilanes revealed that many cells remain on the modified glass plate. In addition, the implantation into the body of immunodeficient mouse of a composite material composed of porous hydroxyapatite and osteoblast showed the formation of a bone-like structure.
authors.affiliation: Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, 12-1 Ichigaya-Funagawara, Shinjuku, Tokyo 162-0826, Japan. yoshino@ci.kagu.tus.ac.jp
authors.forename: Norio
authors.initials: N
authors.lastname: Yoshino
authors.forename: Kaori
authors.initials: K
authors.lastname: Nakajima
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nakamura
authors.forename: Yukishige
authors.initials: Y
authors.lastname: Kondo
authors.forename: Katsura
authors.initials: K
authors.lastname: Ohashi
authors.forename: Tomotaro
authors.initials: T
authors.lastname: Nihei
authors.forename: Masahiro
authors.initials: M
authors.lastname: Saito
authors.forename: Toshio
authors.initials: T
authors.lastname: Teranaka
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002470:Cell Survival; D003593:Cytoplasm; D017886:Durapatite / Q000737:chemistry; D005898:Glass / Q000737:chemistry; D006860:Hydrogen Bonding; D008156:Luciferases / Q000378:metabolism; D049449:Luminescence; D051379:Mice; D016513:Mice, SCID; D010006:Osteoblasts / Q000166:cytology; D010012:Osteogenesis; D012821:Silanes / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D012821:Silanes; D017886:Durapatite; D008156:Luciferases; C071717:trimethoxysilane