title: Kohki tea protects the rabbit bladder from ischemia/reperfusion-induced contractile dysfunction.
abstract: OBJECTIVE
  Results of several studies indicated that ischemia/reperfusion is an etiological factor in obstructive bladder dysfunction. Kohki tea pretreatment was shown to reduce the dysfunctions induced by partial outlet obstruction in rabbits. The current study was designed to determine if pretreatment of rabbits with Kohki tea could prevent the contractile dysfunctions induced by bilateral ischemia followed by reperfusion.
  
  
  METHODS
  New Zealand white rabbits were separated into several groups; one half of each group was pretreated by oral gavage for 3 weeks with Kohki tea and the other half was treated with vehicle (water). Experimental groups were subjected to bilateral ischemia for either 1 or 3 h followed by reperfusion for either 1 h or 1 week (4 groups). The results from the experimental groups were compared to the groups of rabbits receiving sham operations.
  
  
  RESULTS
  Under all experimental conditions, Kohki tea significantly reduced the contractile dysfunctions induced by ischemia and ischemia followed by reperfusion.
  
  
  CONCLUSIONS
  This data is consistent with the concept that Kohki tea acts by protecting the bladder smooth muscle and mucosa from cellular damage caused by ischemia/reperfusion.
authors.affiliation: Stratton VAMC, Albany College of Pharmacy, Albany, NY 12208-3492, USA. levinr@acp.edu
authors.forename: Robert M
authors.initials: RM
authors.lastname: Levin
authors.forename: Robert E
authors.initials: RE
authors.lastname: Leggett
authors.forename: Catherine
authors.initials: C
authors.lastname: Whitbeck
authors.forename: Seiji
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Ohto
authors.forename: Takao
authors.initials: T
authors.lastname: Ikeda
authors.forename: Kenji
authors.initials: K
authors.lastname: Mizutani
authors.forename: Akifumi
authors.initials: A
authors.lastname: Higurashi
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007511:Ischemia / Q000188:drug therapy*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D008517:Phytotherapy; D011336:Probability; D011817:Rabbits; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology; D015427:Reperfusion Injury / Q000517:prevention & control*; D012680:Sensitivity and Specificity; D013662:Tea; D001743:Urinary Bladder / Q000098:blood supply*
chemical_list: D004365:Drugs, Chinese Herbal; D013662:Tea