title: Glucose lowering effects of inhaled insulin in healthy cats.
abstract: Inhaled medications have proven effective and well tolerated in cats, and inhaled insulin has been used successfully for the management of diabetes mellitus in humans. Thus, we hypothesize that delivery of aerosolized regular insulin can lower blood glucose in healthy cats. Five adult cats were administered aerosolized 0.9% saline (IS), regular insulin intravenously (IV) 0.5 U/kg, and aerosolized regular insulin 15 U/kg (I15) and 25 U/kg (I25) and blood glucose was evaluated. Mean blood glucose was significantly lower at 15, 30 and 45 min in the I25 and IV groups compared to baseline. Similarly, the IV and I25 groups had a significantly greater maximal percent change in blood glucose than the IS group. Significantly more cats developed severe hypoglycemia (<50 mg/dl; 2.7 mmol/l) in the IV and I25 groups than in the IS group. Results of this study demonstrate that aerosolized insulin can effectively lower blood glucose concentrations in healthy cats.
authors.affiliation: Department of Veterinary Medicine and Surgery, University of Missouri-College of Veterinary Medicine, 900 East Campus Drive, Columbia, MO 65211, USA. decluea@missouri.edu
authors.forename: Amy E
authors.initials: AE
authors.lastname: DeClue
authors.forename: Elizabeth F
authors.initials: EF
authors.lastname: Leverenz
authors.forename: Charles E
authors.initials: CE
authors.lastname: Wiedmeyer
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Bryan
authors.forename: Carol R
authors.initials: CR
authors.lastname: Reinero
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis* / Q000187:drug effects* / Q000378:metabolism; D002371:Cat Diseases / Q000188:drug therapy; D002415:Cats; D018592:Cross-Over Studies; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000662:veterinary; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous / Q000662:veterinary; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D013047:Specific Pathogen-Free Organisms; D016896:Treatment Outcome
chemical_list: D000336:Aerosols; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin