title: Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients.
abstract: OBJECTIVE
  Comprehensive evaluation of major depressive disorder (MDD), anxiety disorder, and MDD in conjunction with anxiety disorder in stable coronary heart disease (CHD) patients, including cardiac biomarkers such as C-reactive protein (CRP), troponin T (TnT), and amino-terminal pro-B-type brain natriuretic peptide (NT-proBNP).
  
  
  RESULTS
  Cross-sectional study of a consecutive series of 120 stable CHD outpatients (n = 30 with MDD, n = 30 with anxiety disorder, n = 30 with MDD and anxiety disorder, n = 30 with no psychiatric disorder). Psychiatric diagnoses were established by using the structured clinical interview for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders-IV). Binomial logistic regression analyses using cut-off scores of biomarkers as dependent variables showed associations between CRP and generalized anxiety disorder (GAD) (P = 0.04), and education (P = 0.004), whereas MDD, and MDD and anxiety disorder did not reach the significance level. TnT showed relationships with hyperlipidaemia (P = 0.009), history of obesity or overweight (P = 0.04), and education (P = 0.04). NT-proBNP was associated with type II diabetes (P = 0.005).
  
  
  CONCLUSIONS
  After adjusting for relevant demographic, medical, and psychiatric co-variables, CRP was associated with GAD.
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. bettina.bankier@meduniwien.ac.at
authors.forename: Bettina
authors.initials: B
authors.lastname: Bankier
authors.forename: Justine
authors.initials: J
authors.lastname: Barajas
authors.forename: Abelardo
authors.initials: A
authors.lastname: Martinez-Rumayor
authors.forename: James L
authors.initials: JL
authors.lastname: Januzzi
mesh_terms: D000368:Aged; D001008:Anxiety Disorders / Q000175:diagnosis* / Q000209:etiology; D002097:C-Reactive Protein / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000523:psychology*; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D018570:Risk Assessment; D012720:Severity of Illness Index; D020107:Troponin T / Q000378:metabolism
chemical_list: D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein