Effects of a large-scale introduction of the pneumococcal polysaccharide vaccine among elderly persons in Stockholm, Sweden.
In October 1998 Stockholm County launched a 3-year vaccination campaign with the 23-valent pneumococcal polysaccharide vaccine (PPV-23) directed towards all elderly persons. We analysed the impact of this campaign on the incidence and serotype distribution of invasive pneumococcal disease (IPD) in Stockholm County, where the vaccine coverage was 36%, as compared to Skåne County, where no vaccination campaign was performed. The incidence of vaccine-type IPD in Stockholm declined significantly during the study period (1997-2001) in elderly persons, from 50 to 28.9/100,000, but not in other age groups in Stockholm, nor in any age group in Skåne.
Spindler
Carl
C
Karolinska Institutet, Department of Medicine Solna, Infectious Diseases Unit, Karolinska University Hospital, Stockholm, Sweden. carl.spindler@karolinska.se
Hedlund
Jonas
J
Jasir
Aftab
A
Normark
Birgitta Henriques
BH
Ortqvist
Ake
A
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged / Q000706:statistics & numerical data*; D000907:Antibodies, Bacterial / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D032541:Mass Vaccination; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D012703:Serotyping; D012959:Socioeconomic Factors; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult
D000907:Antibodies, Bacterial; D022242:Pneumococcal Vaccines