Role of mixed Th1 and Th2 serum cytokines on pathogenesis and prognosis of hantavirus pulmonary syndrome.
The hantavirus pulmonary syndrome (HPS) is an emerging syndrome in the Americas. The disease results from intense immune activation and changes in vascular permeability. The aim of this study was to determine the profile of serum cytokines in HPS patients looking for correlation with the clinical parameters, severity and outcome of illness. Studying 21 HPS patients, we found that IL-6 may have an important role in the pathogenesis of HPS, being associated with fatal outcome. Our results also support a mixed Th1/Th2 immune response during the course of HPS and that the magnitude of Th1 response effector cytokines is correlated to HPS severity. The decreased levels of TGF-beta observed in HPS patients suggest that immunoregulatory activity could be damaged in these patients.
Borges
Alessandra Abel
AA
Virology Research Center, School of Medicine of Ribeirão Preto, University of São Paulo (USP), Av. Bandeirantes 3900, Ribeirão Preto, São Paulo State, 14049-900, Brazil.
Campos
Gelse Mazzoni
GM
Moreli
Marcos Lázaro
ML
Moro Souza
Ricardo Luiz
RL
Saggioro
Fabiano Pinto
FP
Figueiredo
Glauciane Garcia
GG
Livonesi
Márcia Cristina
MC
Moraes Figueiredo
Luiz Tadeu
LT
D001794:Blood Pressure; D016207:Cytokines / Q000097:blood*; D018450:Disease Progression; D006476:Orthohantavirus / Q000472:pathogenicity; D018804:Hantavirus Pulmonary Syndrome / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007378:Interleukins / Q000097:blood; D008233:Lymphotoxin-alpha / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D011379:Prognosis; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D016207:Cytokines; D007378:Interleukins; D008233:Lymphotoxin-alpha; D009569:Nitric Oxide