title: Highly sensitive determination of iodide by ion chromatography with amperometric detection at a silver-based carbon paste electrode.
abstract: A silver-based solid carbon paste electrode was developed for use as a detector in ion chromatography (IC) for the sensitive determination of iodide in real samples. Micro- and nano-particles of silver were investigated for the fabrication of different electrodes. The iodide assay was based on IC with amperometric detection (IC-AD) at a silver composite electrode polarized at +0.080 V versus Ag/AgCl. Free iodide and organoiodide compounds were studied. The detection process was characterized by studying the redox behavior of iodide ions at both silver and silver composite electrodes by cyclic voltammetry (CV). The presence of iodide ions in solution was found to considerably facilitate metallic silver oxidation, with response currents directly related to iodide concentration. The calibration curve at the selected silver carbon paste electrode was linear in the concentration range comprised between 0.635 microg/L and 63.5 microg/L iodide. The relative standard deviation (R.S.D.) for successive injections was below 3% for all iodide standard solutions investigated. The limit of detection (LOD) was 0.47 microg/L (3.7 nmol/L) for an injection volume of 20 microL, i.e. 74 fmol injected. The IC-AD method was successfully applied to the determination of iodide in complex real samples such as table salts, sea products and iodide bound drug compounds. The analytical accuracy was verified by the assay of iodide in milk powder from an iodide certified reference material (CRM) Community Bureau of Reference (BCR) 150.
authors.affiliation: Université Libre de Bruxelles, Institute of Pharmacy, Campus plaine, CP 205/06, 1050 Brussels, Belgium.
authors.forename: Trésor Kimbeni
authors.initials: TK
authors.lastname: Malongo
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Patris
authors.forename: Pascale
authors.initials: P
authors.lastname: Macours
authors.forename: Frédéric
authors.initials: F
authors.lastname: Cotton
authors.forename: Jean
authors.initials: J
authors.lastname: Nsangu
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Kauffmann
mesh_terms: D002244:Carbon; D002852:Chromatography, Ion Exchange / Q000295:instrumentation* / Q000592:standards; D007454:Iodides / Q000032:analysis*; D017736:Ion-Selective Electrodes / Q000592:standards*; D053768:Metal Nanoparticles; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000737:chemistry; D012834:Silver; D017673:Sodium Chloride, Dietary / Q000032:analysis
chemical_list: D007454:Iodides; D004364:Pharmaceutical Preparations; D017673:Sodium Chloride, Dietary; D012834:Silver; D002244:Carbon