title: Studies on biodegradation of crosslinked hydroxy terminated-poly(proplyene fumarate) and formation of scaffold for orthopedic applications.
abstract: Biodegradation of crosslinked-hydroxy terminated-poly(proplyene fumarate) (X-HTPPF) has been studied in simulated physiological media to assess the formation of porous scaffold structure for bone growth and remodeling in load bearing orthopedic applications. Variation in crosslink density and surface hydrophilicity of X-HTPPF are observed due to non-stoichiometric mass of reacting partners. These variations influence absorption of the medium and biodegradation during aging. Though the initial absorption of medium is relatively higher with the crosslinked polymer (PNVP1) having 63.6% HT-PPF and 36.4% comonomer n-vinyl pyrrolidone (NVP) during the initial period of aging, the weight loss due to subsequent degradation with time is relatively lesser. PNVP1 undergo slow degradation with formation of fibril structure on the surface. The present crosslinked material PNVP1 is a candidate for the load bearing orthopedic applications.
authors.affiliation: Polymer Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695012, Kerala, India.
authors.forename: K T
authors.initials: KT
authors.lastname: Shalumon
authors.forename: M
authors.initials: M
authors.lastname: Jayabalan
mesh_terms: D020341:Absorbable Implants; D018786:Bone Substitutes / Q000138:chemical synthesis / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000494:pharmacology; D005650:Fumarates / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006878:Hydroxides / Q000737:chemistry; D008422:Materials Testing; D008954:Models, Biological; D009985:Orthopedics / Q000379:methods; D011126:Polypropylenes / Q000138:chemical synthesis / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties; D013997:Time Factors; D054457:Tissue Scaffolds / Q000737:chemistry*; D016474:Weight-Bearing
chemical_list: D018786:Bone Substitutes; D003432:Cross-Linking Reagents; D005650:Fumarates; D006878:Hydroxides; D011126:Polypropylenes; C097850:poly(propylene fumarate); C031356:hydroxide ion