title: Simultaneous acquisition of dual analyser-based phase contrast X-ray images for small animal imaging.
abstract: Analyser-based phase contrast X-ray imaging can provide high-contrast images of biological tissues with exquisite sensitivity to the boundaries between tissues. The phase and absorption information can be extracted by processing multiple images acquired at different analyser orientations. Recording both the transmitted and diffracted beams from a thin Laue analyser crystal can make phase retrieval possible for dynamic systems by allowing full field imaging. This technique was used to image the thorax of a mechanically ventilated newborn rabbit pup using a 25 keV beam from the SPring-8 synchrotron radiation facility. The diffracted image was produced from the (111) planes of a 50 mm x 40 mm, 100 microm thick Si analyser crystal in the Laue geometry. The beam and analyser were large enough to image the entire chest, making it possible to observe changes in anatomy with high contrast and spatial resolution.
authors.affiliation: School of Physics, Monash University, Victoria 3800, Australia. Marcus.Kitchen@sci.monash.edu.au
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Kitchen
authors.forename: Konstantin M
authors.initials: KM
authors.lastname: Pavlov
authors.forename: Stuart B
authors.initials: SB
authors.lastname: Hooper
authors.forename: David J
authors.initials: DJ
authors.lastname: Vine
authors.forename: Karen K W
authors.initials: KK
authors.lastname: Siu
authors.forename: Megan J
authors.initials: MJ
authors.lastname: Wallace
authors.forename: Melissa L L
authors.initials: ML
authors.lastname: Siew
authors.forename: Naoto
authors.initials: N
authors.lastname: Yagi
authors.forename: Kentaro
authors.initials: K
authors.lastname: Uesugi
authors.forename: Rob A
authors.initials: RA
authors.lastname: Lewis
mesh_terms: D000465:Algorithms; D000818:Animals; D000831:Animals, Newborn; D004285:Dogs; D021621:Imaging, Three-Dimensional / Q000379:methods / Q000662:veterinary*; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D013902:Radiography, Thoracic / Q000662:veterinary*; D012031:Refractometry / Q000379:methods / Q000662:veterinary*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014056:Tomography, X-Ray / Q000379:methods / Q000662:veterinary*