title: Life-threatening bite injury of the lower lip after use of metamizole.
abstract: BACKGROUND
  Bite wounds of the oral mucosa heal after eliminating the causative irritant, but there are serious exceptions from the rule. We present the case of a 37-year-old woman with an ulcer of the mucosa of the lower lip, which had been present for 10 days, and leucopenia.
  
  
  CONCLUSIONS
  Agranulocytosis after the use of metamizole is part from leukaemia and lues, a rare reason for non-healing ulcers of the mucosa of the oral cavity without fulminant signs for inflammation.
  
  
  CONCLUSIONS
  As this is a life-threatening disease, medical therapy must begin immediately.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Kiel, 24105 Kiel, Germany. becker@mkg.uni-kiel.de
authors.forename: S T
authors.initials: ST
authors.lastname: Becker
authors.forename: J
authors.initials: J
authors.lastname: Wiltfang
authors.forename: I N
authors.initials: IN
authors.lastname: Springer
authors.forename: M S
authors.initials: MS
authors.lastname: Bartsch
authors.forename: R
authors.initials: R
authors.lastname: Guenther
authors.forename: E
authors.initials: E
authors.lastname: Sherry
authors.forename: P H
authors.initials: PH
authors.lastname: Warnke
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced* / Q000188:drug therapy; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001734:Bites, Human / Q000150:complications; D002908:Chronic Disease; D004177:Dipyrone / Q000009:adverse effects*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D008047:Lip Diseases / Q000209:etiology / Q000503:physiopathology; D019226:Oral Ulcer / Q000209:etiology / Q000503:physiopathology; D011994:Recombinant Proteins; D014945:Wound Healing
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D004177:Dipyrone