Cardenolides from Antiaris toxicaria as potent selective Nur77 modulators.
Toxicarioside D (1), a new cardenolide, along with 10 other known ones, was isolated from the stem of Antiaris toxicaria LESCH. by bioassay-guided fractionation. Their structures were determined on the basis of spectroscopic analysis. All the reported compounds effectively inhibited the growth of various cancer cell lines at nanomolar concentrations. Inhibition of cancer cell growth was accompanied with induction of the expression of Nur77, a potent apoptotic member of the steroid/thyroid hormone receptor superfamily.
Jiang
Miao-Miao
MM
College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China.
Dai
Yi
Y
Gao
Hao
H
Zhang
Xue
X
Wang
Guang-Hui
GH
He
Jia-You
JY
Hu
Qiong-Ying
QY
Zeng
Jin-Zhang
JZ
Zhang
Xiao-Kun
XK
Yao
Xin-Sheng
XS
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002298:Cardenolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D012333:RNA, Messenger / Q000032:analysis; D011987:Receptors, Steroid / Q000235:genetics*; D013329:Structure-Activity Relationship
D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides; D004268:DNA-Binding Proteins; C539821:NR4A1 protein, human; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D012333:RNA, Messenger; D011987:Receptors, Steroid