title: [Short-term efficacy of endoscopy-guided debridement on radiation-related nasopharyngeal necrosis in 20 nasopharyngeal carcinoma patients after radiotherapy].
abstract: OBJECTIVE
  Nasopharyngeal necrosis is an unusual sequelae after radiotherapy for nasopharyngeal carcinoma (NPC). It is mostly managed by conservative treatment, but the efficacy is unsatisfied. This study was to investigate the efficacy of endoscopy-guided debridement on irradiation-related nasopharyngeal necrosis in NPC patients after radiotherapy.
  
  
  METHODS
  Between Jul. 2006 and Mar. 2007, 20 NPC patients with irradiation-related nasopharyngeal necrosis after radiotherapy were treated with endoscopy-guided debridement and systemic anti-inflammatory treatment in Cancer Center of Sun Yat-sen University. The short-term outcomes were analyzed. RESULTES: Nasopharyngeal necrosis was cured in 5 patients. Clinical symptoms such as foul odor, headache, and hemorrhage were alleviated in 12 patients. Three patients died of nasopharyngeal massive hemorrhage within 1 year although their clinical symptoms were alleviated.
  
  
  CONCLUSIONS
  Endoscopy-guided debridement is effective in treating irradiation-related nasopharyngeal necrosis, but the prognosis of the NPC patients with severe nasopharyngeal necrosis and internal carotid artery involvement is relatively poor.
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P R China.
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Hua
authors.forename: Ming-Yuan
authors.initials: MY
authors.lastname: Chen
authors.forename: Ming-Huang
authors.initials: MH
authors.lastname: Hong
authors.forename: Chong
authors.initials: C
authors.lastname: Zhao
authors.forename: Ling
authors.initials: L
authors.lastname: Guo
authors.forename: Fei
authors.initials: F
authors.lastname: Han
authors.forename: Wei
authors.initials: W
authors.lastname: Luo
authors.forename: Rui
authors.initials: R
authors.lastname: Sun
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D003646:Debridement / Q000379:methods*; D004724:Endoscopy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D009305:Nasopharynx / Q000473:pathology / Q000528:radiation effects*; D009336:Necrosis; D011878:Radiotherapy / Q000009:adverse effects*