title: Early relapse in a patient with Hodgkin's disease and negative interim FDG-PET.
abstract: The role of F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) in the assessment of lymphoma patients is well established, and PET is routinely used for initial staging, early evaluation of treatment response, and identification of disease relapse. The early evaluation of response to therapy (interim PET) has been reported to be an accurate predictor of progression-free survival, and end-treatment PET has been suggested to be unnecessary if interim PET results are negative. We report on a patient with Hodgkin's disease with a positive PET scan at presentation and a negative interim PET (carried out after three cycles of adriamycin, bleomycin, vinblastine, and dacarbazine; ABVD). Despite uncomplicated clinical course, end-treatment PET (following six cycles) was positive, showing a very early relapse. For this reason, patient underwent further treatment; however, a complete remission was not obtained, and a poor prognosis is expected. This case testifies the possibility of early relapse of lymphoma even in the case of negative interim PET; it also supports the usefulness of end-treatment PET scan in lymphoma patients.
authors.affiliation: Unità Operativa di Medicina Nucleare, Padiglione 30, Azienda Ospedaliero Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Via Massarenti 9, 40138 Bologna, Italy. stefano.fanti@aosp.bo.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Fanti
authors.forename: Paolo
authors.initials: P
authors.lastname: Castellucci
authors.forename: Vittorio
authors.initials: V
authors.lastname: Stefoni
authors.forename: Cristina
authors.initials: C
authors.lastname: Nanni
authors.forename: Monica
authors.initials: M
authors.lastname: Tani
authors.forename: Domenico
authors.initials: D
authors.lastname: Rubello
authors.forename: Valentina
authors.initials: V
authors.lastname: Ambrosini
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Zinzani
authors.forename: Roberto
authors.initials: R
authors.lastname: Franchi
mesh_terms: D000293:Adolescent; D005188:False Negative Reactions; D019788:Fluorodeoxyglucose F18; D006689:Hodgkin Disease / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012008:Recurrence
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18