New anti-inflammatory 4-methylated steroids from the Formosan soft coral Nephthea chabroli.
Eight new 4-methylated steroids, nebrosteroids A-H (1-8) were isolated from the acetone solubles of the Formosan soft coral Nephthea chabroli. The structures were elucidated by extensive NMR spectroscopic analysis and their anti-inflammatory activity was measured in vitro.
Huang
Ya-Ching
YC
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Wen
Zhi-Hong
ZH
Wang
Shang-Kwei
SK
Hsu
Chi-Hsin
CH
Duh
Chang-Yih
CY
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002109:Caffeic Acids / Q000494:pharmacology; D002460:Cell Line; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D008745:Methylation; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives; D012015:Reference Standards; D013055:Spectrophotometry, Infrared; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015854:Up-Regulation / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002109:Caffeic Acids; D004791:Enzyme Inhibitors; D008070:Lipopolysaccharides; D013256:Steroids; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol