[Preparation and evaluation in vivo of Scutellaria thermosensitive gel].
OBJECTIVE
To study scutellaria thermosensitive gel in situ.


METHODS
The phase transition temperature of gel with various concentration polymer solutions was studied by using stirring method and the viscosity of gel was monitored under different temperatures. Eye irritation experiments were performed with rabbit. The duration of residence time in rabbit eyes of scutellaria thermosensitive gel was observed with 2% fluorescein.


RESULTS
20% poloxmar407 and 10% poloxmar 188 were suitable to scutellaria thermosen-sitive gel in situ. The results suggested that the scutellaria thermosensitive gel in situ based on poloxmar were nonirritant and retention time on the surface of eye was (150 +/- 8) min.


CONCLUSIONS
The scutellaria thermosensitive gel in situ forms gel in eye and has longer release time than that of eye drops.
Song
Cheng-Jun
CJ
Bright Way Pharmaceutical Technology limited company, Harbin 150025, China. dragonsongchj@163.com
Wang
Ying
Y
Wang
Chun-Yan
CY
Tian
Lei
L
Liu
Yan-Jun
YJ
Zhang
Rui-Bin
RB
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D005123:Eye / Q000187:drug effects; D005260:Female; D005782:Gels; D008297:Male; D009883:Ophthalmic Solutions / Q000378:metabolism; D020442:Poloxamer / Q000737:chemistry; D011817:Rabbits; D031363:Scutellaria / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D012680:Sensitivity and Specificity; D013997:Time Factors; D044366:Transition Temperature
D004365:Drugs, Chinese Herbal; D005782:Gels; D009883:Ophthalmic Solutions; D020442:Poloxamer