title: Mucoepidermoid carcinoma of the submandibular gland after chemotherapy in a child.
abstract: Second malignant neoplasms (SMNs) have become a concern in survivors of childhood malignancy. Although there are many reports describing SMN in patients treated for childhood cancer, salivary gland tumors rarely appear in these reports. Radiotherapy is a well-known risk factor for the development of secondary salivary gland malignancies after the treatment of childhood cancer. However, it is not well known whether chemotherapy itself treatment increases the risk of salivary gland malignancies. We report a child case with mucoepidermoid carcinoma of the submandibular gland as a SMN after chemotherapy alone for acute myeloid leukemia.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Yeungnam University, Daegu, Republic of Korea.
authors.forename: Hyun-Jae
authors.initials: HJ
authors.lastname: Woo
authors.forename: Chang Hoon
authors.initials: CH
authors.lastname: Bai
authors.forename: Yong-Dae
authors.initials: YD
authors.lastname: Kim
authors.forename: Si-Youn
authors.initials: SY
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D002066:Busulfan / Q000009:adverse effects / Q000627:therapeutic use; D018277:Carcinoma, Mucoepidermoid / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D003561:Cytarabine / Q000009:adverse effects / Q000627:therapeutic use; D003630:Daunorubicin / Q000009:adverse effects / Q000627:therapeutic use; D003907:Dexamethasone / Q000009:adverse effects / Q000627:therapeutic use; D018572:Disease-Free Survival; D005047:Etoposide / Q000009:adverse effects / Q000627:therapeutic use; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D037981:Neck Dissection; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D049268:Positron-Emission Tomography; D013365:Submandibular Gland Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D013866:Thioguanine / Q000009:adverse effects / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D019172:Transplantation Conditioning
chemical_list: D003561:Cytarabine; D005047:Etoposide; D003907:Dexamethasone; D003520:Cyclophosphamide; D013866:Thioguanine; D002066:Busulfan; D003630:Daunorubicin