title: Complexes of the copper-containing amine oxidase from Arthrobacter globiformis with the inhibitors benzylhydrazine and tranylcypromine.
abstract: Complexes of Arthrobacter globiformis amine oxidase (AGAO) with the inhibitors benzylhydrazine and tranylcypromine (an antidepressant drug) have been refined at 1.86 and 1.65 A resolution, respectively. Both inhibitors form covalent adducts with the TPQ cofactor. A tyrosine residue, proposed to act as a gate to the AGAO active site, is in its open conformation.
authors.affiliation: School of Molecular and Microbial Biosciences, University of Sydney, Australia.
authors.forename: David B
authors.initials: DB
authors.lastname: Langley
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Trambaiolo
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Duff
authors.forename: David M
authors.initials: DM
authors.lastname: Dooley
authors.forename: Hans C
authors.initials: HC
authors.lastname: Freeman
authors.forename: J Mitchell
authors.initials: JM
authors.lastname: Guss
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors / Q000737:chemistry*; D001173:Arthrobacter / Q000187:drug effects / Q000201:enzymology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry*; D020134:Catalytic Domain / Q000187:drug effects; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D014191:Tranylcypromine / Q000737:chemistry*
chemical_list: D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D006834:Hydrazines; D014191:Tranylcypromine; C006730:benzylhydrazine; D006631:Amine Oxidase (Copper-Containing)