title: Hansch analysis of veratric acid derivatives as antimicrobial agents.
abstract: The synthesis, characterization and antimicrobial evaluation of a new series of veratric acid derivatives are presented. Preliminary in vitro antimicrobial activity of the title compounds was assessed against a panel of microorganisms including Gram-positive and Gram-negative bacteria and fungi. Some of the veratric acid derivatives exhibited significant in vitro antimicrobial activity. QSAR investigation applied to find a correlation between different physicochemical parameters of the veratric acid derivatives and their antimicrobial activity indicated the importance of topological parameters in describing the antimicrobial activity.
authors.affiliation: Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, Haryana, India. naru2000us@yahoo.com
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Narasimhan
authors.forename: Sucheta
authors.initials: S
authors.lastname: Ohlan
authors.forename: Ruchita
authors.initials: R
authors.lastname: Ohlan
authors.forename: Vikramjeet
authors.initials: V
authors.lastname: Judge
authors.forename: Rakesh
authors.initials: R
authors.lastname: Narang
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D014641:Vanillic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; C009333:veratric acid; D014641:Vanillic Acid