Gypsins A-D from Gypsophila arabica.
Four new cyclopeptides, named gypsins A-D (1- 4), together with one known oleanane saponin, were isolated from the roots of Gypsophila arabica. The structures of cyclo(-Leu(1)-Pro(2)-Leu(3)-Trp(4)-Pro(5)-Gly(6)-) (1), cyclo(-Leu(1)-Pro(2)-Tyr(3)-Phe(4)-Pro(5)-Gly(6)-) (2), cyclo(-Ala(1)-Pro(2)-Tyr(3)-Leu(4)-Leu(5)-Pro (6)-Pro(7)-Ala(8)-) (3), and cyclo(-Leu(1)-Trp(2)-Pro(3)-Gly(4)-Gly(5)-Ser(6)-Ser(7)-) (4) were elucidated by 1D and 2D NMR spectroscopy including 1D-TOCSY, DQF-COSY, 2D-ROESY, HSQC, and HMBC experiments, as well as ESI tandem mass spectrometric fragmentation analysis and chemical evidence.
Bruzual De Abreu
Maryan
M
Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy,
Dal Piaz
Fabrizio
F
Temraz
Abeer
A
Bader
Ammar
A
De Tommasi
Nunziatina
N
Braca
Alessandra
A
D029748:Caryophyllaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D021241:Spectrometry, Mass, Electrospray Ionization
D010456:Peptides, Cyclic