Medical treatment and management of severe ulcerative colitis.
Severe colitis is a life-threatening complication of ulcerative colitis. Early recognition of the severity of the colitis and intensive treatment and monitoring have all contributed to improved outcome. Since their introduction in the 1950s, corticosteroids are the first line therapy for severe active ulcerative colitis (UC). Several prognostic parameters (such as stools movement per day, C-reactive protein, increased amount of intestinal gas or small bowel dilation, hypoalbuminemia, fever, etc.) help the physician to quickly introduce infliximab or cyclosporine or to refer the patient to the surgeon. This decision requires a careful evaluation of the patient and a medical/surgical team.
Rizzello
F
F
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy. fernando.rizzello@unibo.it
Campieri
M
M
Tambasco
R
R
Straforini
G
G
Brugnera
R
R
Poggioli
G
G
Gionchetti
P
P
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000601:surgery; D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D000069285:Infliximab; D012074:Remission Induction; D012720:Severity of Illness Index; D013256:Steroids / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D013256:Steroids; D016572:Cyclosporine; D000069285:Infliximab