[Ischemic postconditioning and its application in organ transplantation].
The concept of "ischemic postconditioning" was first raised in 2002, and the following 5 year research shows that it can protect organs from reperfusion injury. Although the mechanism of ischemic postconditioning is similar to ischemic preconditioning in many ways, it still has its own characteristics. Reperfusion injury is an inevitable problem in organ transplantation. It may accelerate the function recovery of the transplants to lessen the reperfusion injury. So ischemic postconditioning may have a fine prospect in organ transplantation for its good controllability during reperfusion. This article is going to briefly introduce the distinct mechanisms of ischemic postconditioning to protect organs from reperfusion injury and approach the possibilities of its application in organ transplantation.
Niu
Ying
Y
Research Center of Transplantation Medicine Engineering and Technology of National Health Ministry, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Ye
Qi-Fa
QF
D000818:Animals; D006801:Humans; D019194:Ischemic Preconditioning; D019157:Ischemic Preconditioning, Myocardial; D015428:Myocardial Reperfusion Injury / Q000473:pathology / Q000517:prevention & control*; D016377:Organ Transplantation / Q000009:adverse effects / Q000379:methods*; D015427:Reperfusion Injury / Q000517:prevention & control*