title: Biomonitoring Equivalents (BE) dossier for acrylamide (AA) (CAS No. 79-06-1).
abstract: Recent efforts by the US Centers for Disease Control and Prevention and other researchers have resulted in a growing database of measured concentrations of chemical substances in blood or urine samples taken from the general population. However, few tools exist to assist in the interpretation of the measured values in a health risk context. Biomonitoring Equivalents (BEs) are defined as the concentration or range of concentrations of a chemical or its metabolite in a biological medium (blood, urine, or other medium) that is consistent with an existing health-based exposure guideline. This document reviews available pharmacokinetic data and models for acrylamide and applies these data and models to existing health based exposure guidance values from the US Environmental Protection Agency, the Agency for Toxic Substances and Disease Registry, Health Canada, and the World Health Organization, to estimate corresponding BE values for acrylamide in blood and urine. Specifically, BEs are calculated for AA hemoglobin valine terminal adducts [N-(2-carbamoylethyl)valine (AAVal)] and GA hemoglobin valine terminal adducts [N-(2-carbamoyl-2-hydroxyethyl)valine (GAVal)], and the AA glutathione conjugate N-acetyl-S-(2-carbamoylethyl)cysteine (AAMA) in urine. These values can be used as screening tools for evaluation of biomonitoring data for acrylamide in the context of existing risk assessments for acrylamide and for prioritization of the potential need for additional risk assessment and risk management efforts for acrylamide.
authors.affiliation: Summit Toxicology, LLP, 165 Valley Road, Lyons, CO 80540, USA. shays@summittoxicology.com
authors.forename: Sean M
authors.initials: SM
authors.lastname: Hays
authors.forename: Lesa L
authors.initials: LL
authors.lastname: Aylward
mesh_terms: D020106:Acrylamide / Q000032:analysis* / Q000493:pharmacokinetics / Q000633:toxicity; D000818:Animals; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods; D004852:Epoxy Compounds / Q000032:analysis / Q000378:metabolism; D005978:Glutathione / Q000032:analysis / Q000737:chemistry; D017408:Guidelines as Topic; D006454:Hemoglobins / Q000032:analysis / Q000737:chemistry; D006801:Humans; D008954:Models, Biological; D018570:Risk Assessment / Q000379:methods; D012308:Risk Management / Q000379:methods; D014633:Valine / Q000032:analysis / Q000737:chemistry
chemical_list: D004852:Epoxy Compounds; D006454:Hemoglobins; D020106:Acrylamide; C071834:glycidamide; D005978:Glutathione; D014633:Valine