Modularity in the genetic disease-phenotype network.
Similar disease phenotypes are engendered as a result of the modular nature of gene networks; thus we hypothesized that all human genetic disease phenotypes appear in similar modular styles. Network representations of phenotypes make it possible to explore this hypothesis. We investigated the modularity of a network of genetic disease phenotypes. We computationally extracted phenotype modules and found that the modularity is well correlated with a physiological classification of human diseases. We also found correlations between the modularity and functional genomics as well as its connection to drug-target associations.
Jiang
Xingpeng
X
National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, PR China.
Liu
Bing
B
Jiang
Jiefeng
J
Zhao
Huizhi
H
Fan
Ming
M
Zhang
Jing
J
Fan
Zhenjie
Z
Jiang
Tianzi
T
D053263:Gene Regulatory Networks; D030342:Genetic Diseases, Inborn / Q000145:classification* / Q000235:genetics*; D023281:Genomics; D005838:Genotype; D006801:Humans; D010641:Phenotype