Honey prevents hepatic damage induced by obstruction of the common bile duct.
OBJECTIVE
To examine the possible effects of honey supplementation on hepatic damage due to obstruction of the common bile duct in an experimental rat model.


METHODS
The study was performed with 30 male rats divided into three groups: a sham group, an obstructive jaundice group, and an obstructive jaundice plus honey group. At the end of the study period, the animals were sacrificed, and levels of nitric oxide (NO), and NO synthase (NOS) activities were measured in liver tissues, and levels of adenosine deaminase (ADA) and alanine transaminase (ALT) activities were measured in serum.


RESULTS
Blood ALT and ADA activities were significantly elevated in the jaundice group as compared to those of the sham group. In the obstructive jaundice plus honey group, blood ALT and ADA activities were significantly decreased as compared to those of the jaundice group. In erythrocytes and liver tissues, NO levels were found to be significantly higher in the obstructive jaundice plus honey group compared to those of the sham group. Additionally, NO levels were found to be significantly higher in liver tissues from the animals in the obstructive jaundice plus honey group than those of the jaundice group.


CONCLUSIONS
Honey was found to be beneficial in the prevention of hepatic damage due to obstruction of the common bile duct.
Erguder
B Imge
BI
Department of Biochemistry, Ankara University Faculty of Medicine, Ankara 06100, Turkey. imgeerguder@yahoo.com
Kilicoglu
Sibel-S
SS
Namuslu
Mehmet
M
Kilicoglu
Bulent
B
Devrim
Erdinc
E
Kismet
Kemal
K
Durak
Ilker
I
D000243:Adenosine Deaminase / Q000097:blood; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002779:Cholestasis / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D003135:Common Bile Duct / Q000601:surgery; D004195:Disease Models, Animal; D006722:Honey; D041781:Jaundice, Obstructive / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D008026:Ligation; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D020011:Protective Agents; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D000410:Alanine Transaminase; D000243:Adenosine Deaminase