Small heat shock proteins in smooth muscle.
The small heat shock proteins (HSPs) HSP20, HSP27 and alphaB-crystallin are chaperone proteins that are abundantly expressed in smooth muscles are important modulators of muscle contraction, cell migration and cell survival. This review focuses on factors regulating expression of small HSPs in smooth muscle, signaling pathways that regulate macromolecular structure and the biochemical and cellular functions of small HSPs. Cellular processes regulated by small HSPs include chaperoning denatured proteins, maintaining cellular redox state and modifying filamentous actin polymerization. These processes influence smooth muscle proliferation, cell migration, cell survival, muscle contraction and synthesis of signaling proteins. Understanding functions of small heat shock proteins is relevant to mechanisms of disease in which dysfunctional smooth muscle causes symptoms, or is a target of drug therapy. One example is that secreted HSP27 may be a useful marker of inflammation during atherogenesis. Another is that phosphorylated HSP20 which relaxes smooth muscle may prove to be highly relevant to treatment of hypertension, vasospasm, asthma, premature labor and overactive bladder. Because small HSPs also modulate smooth muscle proliferation and cell migration they may prove to be targets for developing effective, novel treatments of clinical problems arising from remodeling of smooth muscle in vascular, respiratory and urogenital systems.
Salinthone
Sonemany
S
Department of Neurology, Oregon Health Sciences University, Portland, OR, USA.
Tyagi
Manoj
M
Gerthoffer
William T
WT
D000818:Animals; D050197:Atherosclerosis / Q000097:blood; D002465:Cell Movement; D002470:Cell Survival; D050886:HSP20 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology*; D055551:HSP27 Heat-Shock Proteins / Q000097:blood / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000502:physiology*; D015398:Signal Transduction; D014664:Vasodilation
D050886:HSP20 Heat-Shock Proteins; D055551:HSP27 Heat-Shock Proteins