title: Synergism between natural products and antibiotics against infectious diseases.
abstract: Antibiotics have been effective in treating infectious diseases, but resistance to these drugs has led to the emergence of new and the reemergence of old infectious diseases. One strategy employed to overcome these resistance mechanisms is the use of combination of drugs, such as beta-lactams together with beta-lactamase inhibitors. Several plant extracts have exhibited synergistic activity against microorganisms. This review describes in detail, the observed synergy and mechanism of action between natural products including flavonoids and essential oils and synthetic drugs in effectively combating bacterial, fungal and mycobacterial infections. The mode of action of combination differs significantly than that of the same drugs acting individually; hence isolating a single component may lose its importance thereby simplifying the task of pharma industries.
authors.affiliation: Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600 036, India.
authors.forename: Shanmugam
authors.initials: S
authors.lastname: Hemaiswarya
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Kruthiventi
authors.forename: Mukesh
authors.initials: M
authors.lastname: Doble
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy*; D001688:Biological Products / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004357:Drug Synergism
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products