title: Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria.
abstract: OBJECTIVE
  We compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria.
  
  
  METHODS
  Twelve pregnant women and 15 nonpregnant women of child-bearing age with acute P. vivax malaria were treated with 25 mg chloroquine base/kg over 3 days on the northwestern border of Thailand. Blood concentrations of chloroquine and desethylchloroquine were measured using hydrophilic interaction liquid chromatography coupled with fluorescence detection. Twenty-five women completed the pharmacokinetic study.
  
  
  RESULTS
  Although increasing gestational age was associated with reduced chloroquine AUC0-->infinity, there was no significant difference overall in the pharmacokinetics of chloroquine between pregnant and nonpregnant women. Fever was associated with lower chloroquine AUC0-->infinity values. Desethylchloroquine area under the curve (AUC) values were not significantly affected by pregnancy.
  
  
  CONCLUSIONS
  Pregnancy did not significantly affect blood concentrations of chloroquine or its metabolite, desethylchloroquine, in women with P. vivax malaria.
authors.affiliation: Mahidol-Oxford Tropical Medicine Research Unit, MORU, Mahidol University, Bangkok, Thailand.
authors.forename: Sue Jean
authors.initials: SJ
authors.lastname: Lee
authors.forename: Rose
authors.initials: R
authors.lastname: McGready
authors.forename: Christine
authors.initials: C
authors.lastname: Fernandez
authors.forename: Kasia
authors.initials: K
authors.lastname: Stepniewska
authors.forename: Moo Koo
authors.initials: MK
authors.lastname: Paw
authors.forename: Samuel Jacher
authors.initials: SJ
authors.lastname: Viladpai-nguen
authors.forename: Kyaw Lay
authors.initials: KL
authors.lastname: Thwai
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Villegas
authors.forename: Pratap
authors.initials: P
authors.lastname: Singhasivanon
authors.forename: Brian M
authors.initials: BM
authors.lastname: Greenwood
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
authors.forename: François
authors.initials: F
authors.lastname: Nosten
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D002738:Chloroquine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016780:Malaria, Vivax / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D010966:Plasmodium vivax / Q000378:metabolism*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000453:epidemiology*; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012189:Retrospective Studies; D013785:Thailand / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000962:Antimalarials; D002738:Chloroquine; C007278:desethylchloroquine