title: The double life of Irs.
abstract: The liver plays a central role in lipid and glucose metabolism. Two studies in this issue (Kubota et al., 2008; Dong et al., 2008) on the insulin-signaling adaptors Irs1 and Irs2 prompt a critical reappraisal of the physiology of fasting and of the integrated control of hepatic insulin action.
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Haeusler
authors.forename: Domenico
authors.initials: D
authors.lastname: Accili
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000818:Animals; D005215:Fasting; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D055504:Insulin Receptor Substrate Proteins; D007333:Insulin Resistance; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D010750:Phosphoproteins / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; C467200:Foxo1 protein, mouse; D055504:Insulin Receptor Substrate Proteins; D047908:Intracellular Signaling Peptides and Proteins; C526295:Irs1 protein, mouse; C526298:Irs2 protein, mouse; D010750:Phosphoproteins; D005947:Glucose