Novel interactions of TG2 with heparan sulfate proteoglycans: reflection on physiological implications.
This mini-review brings together information from publications and recent conference proceedings that have shed light on the biological interaction between transglutaminase-2 and heparan sulphate proteoglycans. We subsequently draw hypotheses of possible implications in the wound healing process. There is a substantial overlap in the action of transglutaminase-2 and the heparan sulphate proteoglycan syndecan-4 in normal and abnormal wound repair. Our latest findings have identified syndecan-4 as a possible binding and signalling partner of fibronectin-bound TG2 and support the idea that transglutaminase-2 and syndecan-4 act in synergy.
Verderio
E A M
EA
School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, UK. elisabetta.verderio-edwards@ntu.ac.uk
Scarpellini
A
A
Johnson
T S
TS
D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism*; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000378:metabolism*
D019812:Heparan Sulfate Proteoglycans; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins