title: Neoadjuvant therapy with sorafenib in advanced renal cell carcinoma with vena cava extension submitted to radical nephrectomy.
abstract: A 71-year-old man with advanced left renal cell carcinoma (lymph node involvement and vena cava thrombus) was submitted to 6 months of neoadjuvant treatment with sorafenib before open radical nephrectomy. After sorafenib treatment and before surgery a new CT scan confirmed the presence of a 9.0 cm in diameter solid mass in the left kidney but a reduction in thrombus extension, limited to the left renal vein. At histological examination after radical nephrectomy, over 90% of the renal mass was substituted by necrotic tissue.
authors.affiliation: Department of Urology, University of Rome, Rome, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Di Silverio
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sciarra
authors.forename: Ulderico
authors.initials: U
authors.lastname: Parente
authors.forename: Alfarone
authors.initials: A
authors.lastname: Andrea
authors.forename: Magnus
authors.initials: M
authors.lastname: Von Heland
authors.forename: Valeria
authors.initials: V
authors.lastname: Panebianco
authors.forename: Roberto
authors.initials: R
authors.lastname: Passariello
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001557:Benzenesulfonates / Q000008:administration & dosage*; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000187:drug effects / Q000473:pathology*; D009392:Nephrectomy / Q000379:methods; D009536:Niacinamide / Q000031:analogs & derivatives; D010671:Phenylurea Compounds; D011725:Pyridines / Q000008:administration & dosage*; D018570:Risk Assessment; D000077157:Sorafenib; D016896:Treatment Outcome; D014682:Vena Cava, Inferior / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D001557:Benzenesulfonates; D010671:Phenylurea Compounds; D011725:Pyridines; D009536:Niacinamide; D000077157:Sorafenib