Concise synthesis of dimemorfan (DF) starting from 3-hydroxymorphinan (3-HM).
Dimemorfan (DF) has been known to possess neuroprotective properties. While this promising compound deserves further biological evaluation, synthetic methods have not improved since Murakami group unveiled the synthetic efforts in 1972. Herein a succinct synthesis toward DF from commercially available 3-hydroxymorphinan (3-HM) is disclosed. Other morphinan analogs have been effectively prepared by adopting the similar methodology.
Kim
Jong Yup
JY
Small Molecule Group, Central Research Institute, Green Cross Corporation, Yongin, Korea.
Kim
Hyoung-Chun
HC
Kim
Jeongmin
J
Lee
Jinhwa
J
D003915:Dextromethorphan / Q000031:analogs & derivatives* / Q000737:chemistry; D009019:Morphinans / Q000138:chemical synthesis*; D018696:Neuroprotective Agents / Q000138:chemical synthesis*
D009019:Morphinans; D018696:Neuroprotective Agents; C012621:dimemorfan; D003915:Dextromethorphan; C054116:norlevorphanol