T-lymphocyte peripheral-type benzodiazepine binding in parkinsonian patients.
Human peripheral blood cells, especially lymphocytes and platelets, are being studied increasingly in neuropsychiatric research both as tools for investigating systemic disturbances in neuropsychiatric disorders, and as peripheral models for getting information on central nervous system biochemistry. In this study, we determined T lymphocyte peripheral-type benzodiazepine binding in parkinsonians and controls: significantly reduced B(max) values were found in patients compared with healthy controls, whereas K(d) values were similar. These data argue for an immune response disturbance and a cell energy metabolism impairment in parkinsonian patients, since cell surface peripheral-type benzodiazepine receptors are related with the immune function, and mitochondrial binding sites with energy metabolic pathways.
Bongioanni
P
P
Scuola Superiore di Studi Universitari e di Perfezionamento Sant'Anna, Via Carducci 40, 56100 Pisa, Italy.
Gemignani
F
F
Ronato
M
M
Castagna
M
M
Mondino
C
C