title: Impact of magnesium sulfate on serum magnesium concentrations and intracellular electrolyte concentrations among patients undergoing radio frequency catheter ablation.
abstract: BACKGROUND
  We evaluated the impact of intravenous magnesium on intracellular magnesium (iMg) and serum magnesium (sMg) in patients undergoing radio frequency catheter ablation (RFCA) for atrial fibrillation (AF).
  
  
  METHODS
  Patients with AF received 4g intravenous magnesium sulfate or normal saline in a randomized, double-blinded fashion. Venous blood and buccal cells were collected for evaluation of sMg and iMg at baseline, postinfusion, at the end of ablation procedure and six-hours posttherapy.
  
  
  RESULTS
  All subjects (n = 18) had baseline sMg within normal range but iMg concentrations below normal in 89% of subjects. Baseline sMg and iMg concentrations were similar between groups. After infusion, the magnesium group had significantly higher sMg concentration than the placebo group over the six hours. In contrast, iMg concentrations were significantly higher than placebo immediately after the infusion (P = 0.007) but not at the end of RFCA or six-hours postinfusion (P = 0.187 and P = 0.267).
  
  
  CONCLUSIONS
  iMg deficiencies exist despite normal sMg concentrations in patients undergoing RFCA. Intravenous magnesium sulfate corrects iMg deficiencies immediately postinfusion.
authors.affiliation: Hartford Hospital, Division of Cardiology, Hartford, CT 06102-5037, USA.
authors.forename: Sachin A
authors.initials: SA
authors.lastname: Shah
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Clyne
authors.forename: Nickole
authors.initials: N
authors.lastname: Henyan
authors.forename: Magdy
authors.initials: M
authors.lastname: Migeed
authors.forename: Ravi
authors.initials: R
authors.lastname: Yarlagadda
authors.forename: Burton B
authors.initials: BB
authors.lastname: Silver
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Kluger
authors.forename: C Michael
authors.initials: CM
authors.lastname: White
mesh_terms: D001281:Atrial Fibrillation / Q000378:metabolism / Q000517:prevention & control / Q000601:surgery; D017115:Catheter Ablation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008274:Magnesium / Q000097:blood* / Q000378:metabolism; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000166:cytology / Q000378:metabolism; D011183:Postoperative Complications / Q000517:prevention & control; D013997:Time Factors
chemical_list: D008278:Magnesium Sulfate; D008274:Magnesium