title: Early predictors of haemorrhage in acute febrile syndrome patients from Bucaramanga, Colombia: a dengue endemic area.
abstract: BACKGROUND
  Spontaneous haemorrhage is an important cause of hospitalisation in dengue patients. Early predictors of these complications could help to make opportune decisions.
  
  
  METHODS
  We prospectively evaluated 51 febrile patients (without previous spontaneous haemorrhage), including 32 cases of dengue fever. Initial evaluation was performed during the first 96 hours after the onset of fever and included complete blood cell count and coagulation tests. Participants were followed-up daily until the seventh day of the disease.
  
  
  RESULTS
  Overall, 15 patients developed spontaneous haemorrhage during the follow-up. Tourniquet test and dengue infection were not associated with haemorrhage (p-value is greater than 0.2). In a logistic regression analysis, platelet count (odds-ratio [OR] 0.78; 95 percent confidence interval [CI] 0.65-0.94) and partial thromboplastin time (OR 1.78; 95 percent CI 1.06-2.99) were independently associated with spontaneous haemorrhage.
  
  
  CONCLUSIONS
  Early alterations in platelet count and coagulation test could predict spontaneous bleeding in the acute febrile syndrome.
authors.affiliation: Centro de Investigaciones Epidemiológicas, Facultad de Salud, Universidad Industrial de Santander, Carrera 32 No 29-31, Bucaramanga, Colombia. fre_diazq@yahoo.com
authors.forename: F A
authors.initials: FA
authors.lastname: Díaz-Quijano
authors.forename: R A
authors.initials: RA
authors.lastname: Martínez-Vega
authors.forename: L A
authors.initials: LA
authors.lastname: Villar-Centeno
mesh_terms: D000208:Acute Disease; D001780:Blood Coagulation Tests; D003105:Colombia; D003715:Dengue; D019353:Endemic Diseases; D005334:Fever / Q000150:complications; D006470:Hemorrhage / Q000175:diagnosis; D006801:Humans; D010976:Platelet Count; D019595:Severe Dengue / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology