title: [A method designed for the assessment of myocardial metabolism in rats with 18F-FDG using small-animal-PET. Initial experience in Mexico].
abstract: OBJECTIVE
  To standarize an acquisition protocol for the study of myocardial metabolism in adult rats.
  
  
  METHODS
  Three Wistar adult male rats were studied in three different protocols: no fasting group, fasting group over a period of 12 hr before the study with only water provided ad libitum, and fasting group by the same time receiving an oral 50% glucose solution. Thirty-minute acquisition images were obtained with a micro-PET, thirty and sixty minutes after the administration of 370-555 MBq 18F-FDG. Comparative and visual analysis were performed by two experts in the field.
  
  
  RESULTS
  Eigtheen studies were analyzed, six per group. The best images were those of the first group, especially those taken at 60 minutes after the 18F-FDG administration.
  
  
  CONCLUSIONS
  It is possible to establish the non-fasting protocol for the assessment of myocardial metabolism to be used in the future for the myocardial viability evaluation in ischemic cardiopathy.
authors.affiliation: Universidad Nacional Autónoma de México (UNAM), Facultad de Medicina, Ciudad Universitaria, México, D.F. 04510. alexanderick@yahoo.com.mx
authors.forename: Erick Alexánderson
authors.initials: EA
authors.lastname: Rosas
authors.forename: Nayelli Ortega
authors.initials: NO
authors.lastname: López
authors.forename: Rafael Ojeda
authors.initials: RO
authors.lastname: Flores
authors.forename: Guillermo Mendoza
authors.initials: GM
authors.lastname: Vázquez
authors.forename: Gloria Adame
authors.initials: GA
authors.lastname: Ocampo
authors.forename: Aloha Meave
authors.initials: AM
authors.lastname: González
authors.forename: Yolanda Saldaña
authors.initials: YS
authors.lastname: Domínguez
authors.forename: Pedro A Lamothe
authors.initials: PA
authors.lastname: Molina
authors.forename: Mónica Rodriguez
authors.initials: MR
authors.lastname: Valero
authors.forename: Leonardo García Rojas
authors.initials: LG
authors.lastname: Castillo
authors.forename: José Narro
authors.initials: JN
authors.lastname: Robles
mesh_terms: D000818:Animals; D019788:Fluorodeoxyglucose F18; D006321:Heart / Q000000981:diagnostic imaging*; D008297:Male; D008800:Mexico; D009206:Myocardium / Q000378:metabolism*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18