Inhibition of developmental processes by flavone in Caenorhabditis elegans and its application to the pinewood nematode, Bursaphelenchus xylophilus.
Flavone (2-phenyl chromone) is a well-known plant flavonoid, but its bioactivity has been little explored. Treatment of Caenorhabditis elegans or C. brissage with flavones induced embryonic and larval lethality that was pronounced in early larval stages. This anti-nematodal effect was also observed in the pinewood nematode, B. xylophilus. LD(50) values were approximately 100 muM for both B. xylophilus and C. elegans. Our results indicate that flavone is an active nematicidal compound that should be further investigated with the aim of developing a potent drug against B. xylophilus.
Lee
Yong-Uk
YU
Department of Bioscience and Biotechnology, and Bio/Molecular Informatics Center, Konkuk University, Seoul 143-701, Korea.
Kawasaki
Ichiro
I
Lim
Yoongho
Y
Oh
Wan-Suk
WS
Paik
Young-Ki
YK
Shim
Yhong-Hee
YH
D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000254:growth & development*; D047309:Flavones; D005419:Flavonoids / Q000494:pharmacology*; D009348:Nematoda / Q000187:drug effects*
D000969:Antinematodal Agents; D047309:Flavones; D005419:Flavonoids; C043562:flavone