[Combined scores of 64 multi-slice CT perfusion characteristics for evaluating solitary pulmonary nodules].
OBJECTIVE
To study the bloody flow mode and the perfusion feature of solitary pulmonary nodules (SPN) on 64 multi-slice CT, and to evaluate the diagnostic value of combined scores in SPN.


METHODS
Fifty-two patients with SPN proved by pathology or follow-up underwent dynamic enhancement CT. Perfusion characteristics, including permeability (P), blood flow, blood volume, patlak blood volume, patlak R square (PRS), patlak residual, peak enhancement, perfusion curve, and false color image were analyzed by the body perfusion software. Perfusion characteristics were compared between benign and malignant nodules. Combined scores composed of significant difference observed parameters were used to differentiate benign or malignant SPN.


RESULTS
There were significant differences in the enhancement values at 20, 22, 24, 25, 26, 28, 30, and 34s, PRS, I or II type perfusion curve, and marginal uncomplete enhancement or patchy complete enhancement at 34s between benign and malignant SPN. With the multi-variant combined score > 0.5 as the threshold value to differentiate benign and malignant SPN, its sensitivity and specificity was 94.3% and 41.2%, respectively.


CONCLUSIONS
The combined scores of 64 multi-slice CT can help differentiate the benign or malignant SPN.
Xu
Jian
J
Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Song
Wei
W
Jin
Zheng-Yu
ZY
Xu
Ying
Y
Wang
Yun
Y
D001810:Blood Volume; D001811:Blood Volume Determination; D006439:Hemodynamics; D006801:Humans; D008175:Lung Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology; D010539:Permeability; D003074:Solitary Pulmonary Nodule / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed