title: Studies on biodegradable and crosslinkable poly(castor oil fumarate)/poly(propylene fumarate) composite adhesive as a potential injectable biomaterial.
abstract: Biodegradable hydroxyl terminated-poly(castor oil fumarate) (HT-PCF) and poly(propylene fumarate) (HT-PPF) resins were synthesized as an injectable and in situ-cross linkable polyester resins for orthopedic applications. An injectable adhesive formulation containing this resin blend, N-vinyl pyrrolidone (NVP), hydroxy apatite, free radical initiator and accelerator was developed. The Composite adhesives containing the ratio of resin blend and NVP, 2.1:1.5, 2.1:1.2 and 2.1:1.0 set fast with tolerable exothermic temperature as a three dimensionally cross linked toughened material. Crosslink density and mechanical properties of the crosslinked composite increase with increase of NVP. The present crosslinked composite has hydrophilic character and cytocompatibility with L929 fibroblast cells.
authors.affiliation: Polymer Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695012, India.
authors.forename: M K
authors.initials: MK
authors.lastname: Mitha
authors.forename: M
authors.initials: M
authors.lastname: Jayabalan
mesh_terms: D020341:Absorbable Implants; D000269:Adhesives / Q000008:administration & dosage* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D018786:Bone Substitutes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002368:Castor Oil / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003432:Cross-Linking Reagents / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects / Q000502:physiology; D005650:Fumarates / Q000737:chemistry*; D007267:Injections; D008422:Materials Testing; D051379:Mice; D008954:Models, Biological; D011126:Polypropylenes / Q000737:chemistry*
chemical_list: D000269:Adhesives; D001672:Biocompatible Materials; D018786:Bone Substitutes; D003432:Cross-Linking Reagents; D005650:Fumarates; D011126:Polypropylenes; C097850:poly(propylene fumarate); D002368:Castor Oil