title: Post-delivery oxidative stress in women with preeclampsia or IUGR.
abstract: OBJECTIVE
  To compare oxidative stress in patients with preeclampsia (PE) or intrauterine growth restriction (IUGR) vs. normal pregnancy (controls) during 48 h after delivery.
  
  
  METHODS
  Women with singleton pregnancies were recruited immediately after delivery (gestational age >26.0 weeks). Women with PE or IUGR were matched with healthy controls by age, BMI, gestational age and delivery mode. Venous blood samples and urine samples were tested for oxidative stress products 24 h and 48 h after delivery.
  
  
  RESULTS
  Plasma malondialdehyde (MDA) concentration 24 h after delivery was significantly higher in subjects with PE or IUGR (3.41+/-1.14 micromol/L, n=20) than in controls (2.91+/-0.82 micromol/L, n=38) (P=0.04). Urine iPF(2alpha)-VI declined from 24 to 48 h after delivery significantly in controls (P=0.006) and not in subjects with PE or IUGR (P=0.71).
  
  
  CONCLUSIONS
  Of the markers tested only MDA is indicating higher oxidative stress in women with PE/IUGR than in normal pregnancy and only at 24 h after delivery. No consistent pattern of change in the oxidative stress markers exists between 24-48 h after delivery.
authors.affiliation: Department of Obstetrics, Zurich University Hospital, Zurich, Switzerland.
authors.forename: Patricia
authors.initials: P
authors.lastname: Kressig
authors.forename: Ernst
authors.initials: E
authors.lastname: Beinder
authors.forename: Horst
authors.initials: H
authors.lastname: Schweer
authors.forename: Roland
authors.initials: R
authors.lastname: Zimmermann
authors.forename: Ursula
authors.initials: U
authors.lastname: von Mandach
mesh_terms: D000328:Adult; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology; D011225:Pre-Eclampsia / Q000097:blood / Q000378:metabolism* / Q000652:urine; D011247:Pregnancy; D018709:Statistics, Nonparametric
chemical_list: C115626:8,12-iso-isoprostane F2alpha-VI; D008315:Malondialdehyde; D015237:Dinoprost