[Study on the antimutagenicity of Cordyceps taii polysaccharide].
OBJECTIVE
To study the antimutagenicity of Cordyceps taii polysaccharide (CDPl).


METHODS
Ames test and micronucleus form assay of polychromatic erythrocytes in mice bone marrow were used to evaluate the antimutagenic effect of CDPI with different concentrations.


RESULTS
CDP1 could inhibit the reverse mutation on Salmonella typhimuriun strains TA97, TA98, TA100 and TA102 without S9 in different degree, especially remarkable in the strains T97 ,T98 and T102. The maxium inhibition rates of strains TA97, TA98, TA100 and T102 were 68.5%, 79.5%,19. 8% and 81.3%, respectively. In addition, CDPI could significantly reduce micronucleus frequencies induced by cyclophosphamide, and the rate of maxium inhibition was 70.3%.


CONCLUSIONS
Cordyceps taii polysaccharide possesses significantly antimutagenic properties.
Peng
Ke-jun
KJ
Department of Immunology, Guiyang Medical College, Guiyang 550004, China.
Liu
Jie-lin
JL
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000378:metabolism; D032661:Cordyceps / Q000737:chemistry*; D003520:Cyclophosphamide; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D015162:Micronucleus Tests / Q000379:methods; D009153:Mutagens / Q000633:toxicity; D009154:Mutation; D011134:Polysaccharides / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics
D016587:Antimutagenic Agents; D009153:Mutagens; D011134:Polysaccharides; D003520:Cyclophosphamide