title: Comparison of 30 immunity-related genes from the common marmoset with orthologues from human and mouse.
abstract: In the evolution of primates, the common marmoset belongs to the new world monkey family and is distinct from the great ape family (which includes humans). In this study, we predicted the amino acid sequences of 30 immunity-related genes from the common marmoset and compared them with those from human and mouse. The domain composition of each orthologous protein was analyzed by the SMART tool and was found to be the same among the three species. A BLAST search revealed that the common marmoset and human proteins were 86% identical on average, whereas the conservation between the common marmoset and mouse or between the human and mouse was only 60%. This indicates that the common marmoset and human proteins are closely related and are similarly divergent from the mouse. We divided the 30 proteins into two categories based on the degree of conservation between the common marmoset and mouse amino acid sequences. One group included 19 proteins and had a relatively high level of conservation (68% identical), whereas the other 11 proteins were less conserved (45% identical). This suggests that these immunity-related genes do not evolve at a uniform rate. Interestingly, however, ligand/receptor pairs such as interleukin-6 and interleukin-6 receptor appear to have evolved simultaneously.
authors.affiliation: Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kohu
authors.forename: Eiji
authors.initials: E
authors.lastname: Yamabe
authors.forename: Ayako
authors.initials: A
authors.lastname: Matsuzawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Onda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suemizu
authors.forename: Erika
authors.initials: E
authors.lastname: Sasaki
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Tanioka
authors.forename: Hideo
authors.initials: H
authors.lastname: Yagita
authors.forename: Daisuke
authors.initials: D
authors.lastname: Suzuki
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Kametani
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Toyoda
authors.forename: Sonoko
authors.initials: S
authors.lastname: Habu
authors.forename: Masanobu
authors.initials: M
authors.lastname: Satake
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002144:Callithrix; D003198:Computer Simulation; D017124:Conserved Sequence; D018076:DNA, Complementary / Q000737:chemistry*; D019143:Evolution, Molecular; D005796:Genes / Q000276:immunology*; D006801:Humans; D051379:Mice; D018448:Models, Immunological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010802:Phylogeny; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
chemical_list: D018076:DNA, Complementary