Erythromycin resistance caused by erm(A) subclass erm(TR) in a Danish invasive pneumococcal isolate: are erm(A) pneumococcal isolates overlooked?
Erm(A) is rarely reported as erythromycin resistance determinant in pneumococci. One invasive erm(A) isolate was initially tested intermediate erythromycin resistant using E-test. However, upon re-testing it was resistant, thus close to the breakpoint value. This may be a reason why erm(A) only rarely is reported to cause resistance in pneumococci.
Lambertsen
Lotte
L
Neisseria and Streptococcus Reference, Department for Bacteriology, Mycology and Parasitology, Statens Serum Institute, Copenhagen, Denmark. llm@ssi.dk
Ekelund
Kim
K
Hansen
Dennis S
DS
Kaltoft
Margit
M
Christensen
Jens J
JJ
Hammerum
Anette M
AM
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008780:Methyltransferases / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004917:Erythromycin; D008780:Methyltransferases; C431709:ErmA protein, Bacteria