title: Atypical autoimmune polyglandular syndrome type 3 overlapped by chronic HCV infection resulting in carcinogenesis and fatal infection.
abstract: The case of a woman with insulin-dependent diabetes mellitus, autoimmune thyroiditis, atrophic gastritis, pernicious anemia, and immunologic thrombocytopenic purpura consisting of autoimmune polyglandular syndrome type 3 associated with a history of gonadal failure is reported. Hepatitis C viral infection added xerophthalmia, lymphocytic sialadenitis, and exacerbation of idiopathic thrombocytopenic purpura. This unique disease constellation was complicated with splenic marginal zone lymphoma and gastric carcinoids. A lung infection, initially treated on an outpatient basis, proved fatal to the patient.
authors.affiliation: Department of Internal Medicine, Hippokration General Hospital, Athens, Greece.
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Elefsiniotis
authors.forename: Georgios
authors.initials: G
authors.lastname: Papatsimpas
authors.forename: George D
authors.initials: GD
authors.lastname: Liatsos
authors.forename: Anna
authors.initials: A
authors.lastname: Tasidou
authors.forename: Antonios
authors.initials: A
authors.lastname: Moulakakis
mesh_terms: D017809:Fatal Outcome; D005260:Female; D005335:Fever of Unknown Origin / Q000150:complications; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008223:Lymphoma / Q000150:complications*; D008303:Malignant Carcinoid Syndrome / Q000150:complications*; D008875:Middle Aged; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications*; D013160:Splenic Neoplasms / Q000150:complications*