title: Expression pattern of Wnt inhibitor factor 1(Wif1) during the development in mouse CNS.
abstract: Wnt inhibitor factor-1 (WIF-1) is an extracellular antagonist of Wnts secreted proteins. Here we describe the expression pattern of Wif1 throughout the development of the mouse central nervous system (CNS). Wif1 mRNA can be detected as early as the developmental stage E11, and expression persists to adulthood. In embryonic stages, the level of Wif1 expression was very prominent in several areas including the cerebral cortex, the diencephalon and the midbrain, with the strongest level in the hippocampal plate and the diencephalon. However, after birth, the expression level of Wif1 decreased in the cortex and diencephalon. By adulthood, Wif1 is mainly expressed in the medial habenular nucleus (MHb) in the epithalamus, the mitral layer cells in the olfactory bulb and a few nuclei in the hypothalamus. Our data shows that the expression of Wif1 was very strong during embryonic development of the CNS and suggests that Wif1 may play an essential role in the spatial and temporal regulation of Wnt signals.
authors.affiliation: Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, School of Medicine, Southeast University, 87 Dingjiaoqiao Road, Nanjing, Jiangsu 210009, PR China.
authors.forename: Yu-An
authors.initials: YA
authors.lastname: Hu
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Gu
authors.forename: Junhua
authors.initials: J
authors.lastname: Liu
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.forename: Chunjie
authors.initials: C
authors.lastname: Zhao
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism; D002490:Central Nervous System / Q000196:embryology* / Q000378:metabolism*; D002531:Cerebellum / Q000196:embryology / Q000378:metabolism; D004027:Diencephalon / Q000196:embryology / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D017403:In Situ Hybridization; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D008636:Mesencephalon / Q000196:embryology / Q000378:metabolism; D051379:Mice / Q000196:embryology* / Q000235:genetics*; D013116:Spinal Cord / Q000196:embryology / Q000378:metabolism; D013687:Telencephalon / Q000196:embryology / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D016326:Extracellular Matrix Proteins; D036341:Intercellular Signaling Peptides and Proteins; C118544:Wif1 protein, mouse