Temporal cortex dopamine D2/3 receptor binding in major depression.
The aim of this study was to assess the dopamine function of the temporal cortex in major depressive disorder using [(123)I]epidepride to image D(2/3) receptor binding sites. Ten major depressives and 10 healthy controls were selected from a general population sample for single-photon emission computed tomography imaging. Among the major depressives there was a strong bilateral correlation between the scores on the 21-item Hamilton Depression Rating Scale and D(2/3) receptor binding. Dopaminergic abnormalities may be present in the temporal cortices of major depressives.
Lehto
Soili M
SM
Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland. soili.lehto@kuh.fi
Kuikka
Jyrki
J
Tolmunen
Tommi
T
Hintikka
Jukka
J
Viinamäki
Heimo
H
Vanninen
Ritva
R
Haatainen
Kaisa
K
Koivumaa-Honkanen
Heli
H
Honkalampi
Kirsi
K
Tiihonen
Jari
J
D000328:Adult; D001549:Benzamides; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000523:psychology; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2 / Q000502:physiology*; D050637:Receptors, Dopamine D3 / Q000502:physiology*; D013223:Statistics as Topic; D013702:Temporal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon
D001549:Benzamides; D007457:Iodine Radioisotopes; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; C063525:epidepride