Gallic acid-based indanone derivatives as anticancer agents.
Gallic acid-based indanone derivatives have been synthesised. Some of the indanones showed very good anticancer activity in MTT assay. Compounds 10, 11, 12 and 14 possessed potent anticancer activity against various human cancer cell lines. The most potent indanone (10, IC(50)=2.2 microM), against MCF-7, that is, hormone-dependent breast cancer cell line, showed no toxicity to human erythrocytes even at higher concentrations (100 microg/ml, 258 microM). While, indanones 11, 12 and 14 showed toxicities to erythrocytes at higher concentrations.
Saxena
Hari Om
HO
Rain Forest Research Institute, Jorhat, India.
Faridi
Uzma
U
Srivastava
Suchita
S
Kumar
J K
JK
Darokar
M P
MP
Luqman
Suaib
S
Chanotiya
C S
CS
Krishna
Vinay
V
Negi
Arvind S
AS
Khanuja
S P S
SP
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D004912:Erythrocytes / Q000187:drug effects; D005707:Gallic Acid / Q000737:chemistry*; D006461:Hemolysis; D006801:Humans; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D009995:Osmosis; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology
D000970:Antineoplastic Agents; D000975:Antioxidants; D007189:Indans; D013778:Tetrazolium Salts; D013844:Thiazoles; D005707:Gallic Acid; C022616:thiazolyl blue