title: Pediatric human immunodeficiency virus infection and circulating IgD+ memory B cells.
abstract: Levels of circulating naive and memory B cells were measured in human immunodeficiency virus (HIV)-infected children and control subjects to determine whether the irreversible depletion of memory B cells described in HIV-infected adults occurs in children with HIV infection. Depletion of circulating IgD+ memory B cells was seen in HIV-infected children despite control of the HIV load with highly active antiretroviral therapy (HAART) (P =. 04). IgD+ memory B cell percentages did not correlate with CD4+ cell percentages (P =. 027) or disease duration (P =. 026). Naive/transitional and IgD- memory B cell numbers were not affected. Pediatric HIV infection is associated with selective depletion of circulating IgD+ memory B cells despite control of the HIV load with HAART.
authors.affiliation: Infectious Diseases and Microbiology Unit, Hugh and Catherine Stevenson Centre for Childhood Infectious Diseases and Immunology, Institute of Child Health, University College London, United Kingdom.
authors.forename: Marianne C
authors.initials: MC
authors.lastname: Jacobsen
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Thiébaut
authors.forename: Christopher
authors.initials: C
authors.lastname: Fisher
authors.forename: Delali
authors.initials: D
authors.lastname: Sefe
authors.forename: Margaret
authors.initials: M
authors.lastname: Clapson
authors.forename: Nigel
authors.initials: N
authors.lastname: Klein
authors.forename: Helen E
authors.initials: HE
authors.lastname: Baxendale
mesh_terms: D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active; D001402:B-Lymphocytes; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D007072:Immunoglobulin D / Q000097:blood*; D007156:Immunologic Memory; D008297:Male; D010372:Pediatrics; D019562:Viral Load / Q000706:statistics & numerical data
chemical_list: D007072:Immunoglobulin D