title: Latent development of occlusive coronary atherosclerosis as a cause of decompensation of non-ischemic dilated cardiomyopathy.
abstract: Four patients with chronically well-compensated, non-ischemic dilated cardiomyopathy (NIDC) presented with occlusive atherosclerotic coronary artery disease as the cause of subacute decompensation (FC III-IV heart failure) 8-13 years following the diagnosis of NIDC. In addition to the atherogenic condition of heart failure, 3 of the patients acquired major atherosclerotic risk factors (dyslipidemia, diabetes mellitus) during the interval between the diagnoses of NIDC and problematic atherosclerotic coronary disease. For each patient, dyspnea on exertion was the primary symptom during the subacute decompensation. Only 1 patient noted precordial chest pain in the form of atypical angina during some of the dyspneic events. The diagnosis of occlusive coronary artery disease was made by coronary angiography, followed by angioplasty-stent deployment in 3 patients and coronary artery bypass surgery in 1; all improved to their baseline FC I-II status following these coronary interventions. As survival of patients with NIDC increases, occlusive coronary artery disease may enter an otherwise stable clinical course to provoke unanticipated decompensation (principally dyspnea), and can do so without causing angina pectoris as a heralding symptom.
authors.affiliation: Division of Cardiovascular Medicine, Ohio State University College of Medicine and Public Health, Columbus, Ohio, USA.
authors.forename: Bryan M
authors.initials: BM
authors.lastname: White
authors.forename: Rohit
authors.initials: R
authors.lastname: Mehta
authors.forename: Philip F
authors.initials: PF
authors.lastname: Binkley
authors.forename: Carl V
authors.initials: CV
authors.lastname: Leier
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000453:epidemiology / Q000209:etiology*; D002311:Cardiomyopathy, Dilated / Q000453:epidemiology / Q000209:etiology*; D003324:Coronary Artery Disease / Q000150:complications* / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D006333:Heart Failure / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors