title: A 12-month feeding study of reproduction/development in rats fed meat/milk powder supplemented diets derived from the progeny of cloned cattle produced by somatic cell nuclear transfer.
abstract: The present 12-month feeding study was carried out with rat groups fed a diet supplemented with meat or milk (meat/milk) derived from the progeny of clones produced by somatic cell nuclear transfer (SCNT) technology. It was conducted to obtain data concerning the chronic toxicities of these edible products during the process of development and reproduction in rats fed such products. The rats were subjected to clinical observations for general health condition and examinations such as sensory/reflex function, grip strength, motor activity, body weight, food consumption, ophthalmology and urinalysis. Moreover, sexually matured rats fed the test diets were mated and examined for items such as the reproductive performances of the dams and health of their pups. After the feeding period, factors related to rat health status, based on the findings for hematology, blood biochemistry, necropsy, organ weight and histology, were examined. There were no biologically significant differences in these factors between the rat groups fed meat/milk powder supplemented diets derived from the progeny and those fed meat/milk powder supplemented diets derived from conventionally bred cattle. Therefore, the present chronic toxicity study suggests that meat and milk derived from the progeny of SCNT cattle might be equivalent to those derived from conventionally bred cattle in use as dietary supplements for rats.
authors.affiliation: Department of Toxicology, Research Institute for Animal Science in Biochemistry and Toxicology, Kanagawa, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Masaya
authors.initials: M
authors.lastname: Itoh
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Ito
authors.forename: Shinya
authors.initials: S
authors.lastname: Watanabe
mesh_terms: D000821:Animal Feed; D000818:Animals; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000502:physiology; D002417:Cattle; D019976:Cloning, Organism / Q000379:methods / Q000662:veterinary; D019587:Dietary Supplements; D004435:Eating / Q000502:physiology; D005260:Female; D048788:Growth and Development / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008460:Meat; D008892:Milk / Q000502:physiology; D009043:Motor Activity / Q000502:physiology; D053652:Nuclear Transfer Techniques / Q000662:veterinary; D011208:Powders / Q000494:pharmacology; D051381:Rats; D012098:Reproduction / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D016482:Urinalysis
chemical_list: D011208:Powders