200th anniversary of lactate research in muscle.
This year, 2008, marks the bicentennial of research into lactate metabolism in muscle. Berzelius linked lactate accumulation to exercise in 1807/1808 when he noted the presence of lactate in the muscles of "hunted stags." Today, the exact mechanism of intramuscular lactate oxidation and the relationship of lactate dehydrogenase to mitochondria remain unresolved as animated debate surrounds the intracellular lactate shuttle.
Gladden
L Bruce
LB
Department of Kinesiology, Auburn University, Auburn, AL 36849-5323, United States. gladdlb@auburn.edu
D015444:Exercise / Q000502:physiology; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D042541:Intracellular Space; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D019344:Lactic Acid / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000378:metabolism; D018482:Muscle, Skeletal; D010827:Physiology / Q000266:history; D012106:Research
D007527:Isoenzymes; D019344:Lactic Acid; D007770:L-Lactate Dehydrogenase