title: A preliminary study on the prevalence of intestinal microsporidiosis in patients with and without gastrointestinal symptoms in Malaysia.
abstract: An observational study was carried out to establish the existence of intestinal microsporidiosis among patients with and without gastrointestinal symptoms in Hospital Universiti Kebangsaan Malaysia, Malaysia. A total of 893 faecal specimens from hospitalized patients were examined for microsporidia using a modification of the usual Gram-chromotrope stain technique. One hundred and sixteen (13.0%) patients were positive for microsporidia: 84 (72.4%), 27 (23.3%) and 5 (4.3%) were low, moderate and high excreters of microsporidia spores, respectively. Of the 91 patients with available medical records, microsporidiosis was commonly observed in children aged 0-6 years (26.4%) and adults aged >or=31 years (57.2%). About one-third of this infection was observed in immunocompetent individuals. Among the immunosuppressive group, microsporidia were observed to be more prevalent in patients with haematological malignancy or a combination of malignancy and diabetes mellitus. About 74% of the patients who had microsporidia in their faeces had gastrointestinal symptoms, which could be related to infections or induced by immunosuppressive therapy. The role of microsporidia in causing gastrointestinal symptoms in this population is as yet unclear.
authors.affiliation: Department of Parasitology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia. halmekhlafi@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Norhayati
authors.forename: M
authors.initials: M
authors.lastname: Azlin
authors.forename: M Hesham
authors.initials: MH
authors.lastname: Al-Mekhlafi
authors.forename: N
authors.initials: N
authors.lastname: Anisah
authors.forename: U
authors.initials: U
authors.lastname: Nor Aini
authors.forename: M S
authors.initials: MS
authors.lastname: Fatmah
authors.forename: A R
authors.initials: AR
authors.lastname: Rozlida
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007223:Infant; D007410:Intestinal Diseases / Q000175:diagnosis / Q000453:epidemiology*; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D016814:Microsporidia / Q000302:isolation & purification; D016881:Microsporidiosis / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D009894:Opportunistic Infections / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D055815:Young Adult