Substrate mediated reduction of copper-amyloid-beta complex in Alzheimer's disease.
X-Ray absorption near-edge spectroscopy (XANES) has been used to probe the substrate mediated reduction of Cu(2+) in Abeta-Cu(2+) complexes by ascorbate and the neurotoxin 6-hydroxydopamine (6-OHDA), however dopamine and, in particular, cholesterol are incapable of reducing soluble monomeric Abeta-Cu(2+) complexes.
Streltsov
Victor A
VA
CSIRO Molecular and Health Technologies and P-Health Flagship, Parkville, VIC 3052, Australia. victor.streltsov@csiro.au
Varghese
Joseph N
JN
D000042:Absorption; D000544:Alzheimer Disease / Q000378:metabolism*; D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism*; D003300:Copper / Q000378:metabolism*; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D013816:Thermodynamics
D016229:Amyloid beta-Peptides; D003300:Copper