Ursodeoxycholic acid treatment for patients with postcholecystectomy pain and bile microlithiasis.
BACKGROUND
Microlithiasis has been identified as a cause of idiopathic acute pancreatitis in patients with an intact gallbladder. Microlithiasis has also been identified in the bile of some patients who have undergone cholecystectomy. However, it is unknown whether bile microlithiasis causes postcholecystectomy pain.


OBJECTIVE
To identify bile microlithiasis in patients with postcholecystectomy pain and to investigate the therapeutic effect of ursodeoxycholic acid (urso) on such patients with microlithiasis in the bile.


METHODS
Prospective randomized trial.


METHODS
Tertiary medical center.


METHODS
Patients with postcholecystectomy pain and bile crystals.


METHODS
Urso treatment.


METHODS
The severity and frequency of right upper-quadrant abdominal pain were compared with and without urso treatment, and before and after urso treatment.


RESULTS
A total of 118 patients with postcholecystectomy pain were screened for the study. Twelve patients (10%) were identified with bile crystals. In the first phase, 6 of these patients received urso treatment, whereas the other 6 patients did not receive urso treatment. In the second phase, the latter 6 patients were given the urso treatment. After using urso for a few months, their biliary-type abdominal pain significantly improved or resolved. In the control group, there was no improvement in symptoms. There was a significant difference between the 2 groups (P = .01).


CONCLUSIONS
Single-center, small number of patients.


CONCLUSIONS
This study provided evidence that supports the hypothesis that bile microlithiasis is indeed a cause for postcholecystectomy pain. Patients with such postcholecystectomy pain may benefit from a microscopic examination of bile for crystals or microlithiasis, and urso treatment if bile crystals are identified.
Okoro
Ngozi
N
Division of Digestive Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia 30322, USA.
Patel
Amil
A
Goldstein
Marney
M
Narahari
Naveen
N
Cai
Qiang
Q
D000328:Adult; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000379:methods; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects* / Q000379:methods; D042883:Choledocholithiasis / Q000175:diagnosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020347:Lithiasis / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy*; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
D014580:Ursodeoxycholic Acid