From the first protein structures to our current knowledge of protein folding: delights and scepticisms.
Every breakthrough that opens new vistas also removes the ground from under the feet of other scientists. The scientific joy of those who have seen the new light is accompanied by the dismay of those whose way of life has been changed for ever. The publication of the first structures of proteins at atomic resolution 50 years ago astounded and inspired scientists in every field, but caused others to flee or scoff. That advance and every subsequent paradigm-shifting breakthrough in protein science have met with some resistance before universal acceptance. I relate these events and their impact on the field of protein folding.
Fersht
Alan R
AR
Department of Chemistry, MRC Centre for Protein Engineering, MRC Centre, Cambridge, UK. arf25@cam.ac.uk
D000818:Animals; D003198:Computer Simulation; D023281:Genomics / Q000639:trends; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D021621:Imaging, Three-Dimensional; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D011487:Protein Conformation; D015202:Protein Engineering / Q000266:history / Q000639:trends; D017510:Protein Folding; D011994:Recombinant Proteins / Q000737:chemistry
D011994:Recombinant Proteins