Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms.
Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. Self-emulsifying drug delivery systems (SEDDS) are usually used to improve the bioavailability of hydrophobic drugs. Conventional SEDDS, however, are mostly prepared in a liquid form, which can produce some disadvantages. Accordingly, solid SEDDS (S-SEDDS), prepared by solidification of liquid/semisolid self-emulsifying (SE) ingredients into powders, have gained popularity. This article gives an overview of the recent advances in the study of S-SEDDS, especially the related solidification techniques and the development of solid SE dosage forms. Finally, the existing problems and the possible future research directions in this field are pointed out.
Tang
Bo
B
Shenyang Pharmaceutical University, Shenyang City 110016, Liaoning Province, People's Republic of China. tangbobox@126.com
Cheng
Gang
G
Gu
Jian-Chun
JC
Xu
Cai-Hong
CH
D000818:Animals; D001702:Biopharmaceutics; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D016503:Drug Delivery Systems; D004655:Emulsions; D006801:Humans
D004304:Dosage Forms; D004655:Emulsions