title: Quantification of regional myocardial blood flow using first-pass multidetector-row computed tomography and adenosine triphosphate in coronary artery disease.
abstract: BACKGROUND
  The feasibility of using cardiac multidetector-row computed tomography (MDCT) technology in the quantitative assessment of myocardial blood flow (MBF) using the adenosine triphosphate (ATP) load technique was investigated in the present study.
  
  
  RESULTS
  The study group comprised 14 patients (11 men, 3 women, age range 52-79 years, mean age 69.2 years) who underwent cardiac cine MDCT using the ATP-load technique. MBF was estimated from the slope of the linear regression equation with Patlak plots analysis. The overall average MBF was 1.83+/-0.62 ml . g(-1) . min(-1). Mean MBF in territories with stenosis on coronary angiography was 1.19+/-0.36 ml . g(-1) . min(-1) and 2.06+/-0.54 ml . g(-1) . min(-1) (p<0.01) in territories without stenosis. The average MBF in territories with moderate to severe ischemia on myocardial perfusion scintigraphy was 1.32+/-0.14 ml .g(-1 ). min(-1 )and 1.95+/-0.64 ml . g(-1) . min(-1) (p<0.01) in territories without ischemia.
  
  
  CONCLUSIONS
  MDCT can be used to quantify MBF using first-pass dynamic data.
authors.affiliation: Department of Diagnostic and Therapeutic Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon 791-0295, Japan. kids@ehm.enjoy.ne.jp
authors.forename: Teruhito
authors.initials: T
authors.lastname: Kido
authors.forename: Akira
authors.initials: A
authors.lastname: Kurata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Higashino
authors.forename: Yuma
authors.initials: Y
authors.lastname: Inoue
authors.forename: Rene Epunza
authors.initials: RE
authors.lastname: Kanza
authors.forename: Hideki
authors.initials: H
authors.lastname: Okayama
authors.forename: Jitsuo
authors.initials: J
authors.lastname: Higaki
authors.forename: Kenya
authors.initials: K
authors.lastname: Murase
authors.forename: Teruhito
authors.initials: T
authors.lastname: Mochizuki
mesh_terms: D000255:Adenosine Triphosphate; D000368:Aged; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D003326:Coronary Circulation; D005080:Exercise Test; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D013794:Thallium Radioisotopes; D000255:Adenosine Triphosphate