title: Pseudotumours associated with metal-on-metal hip resurfacings.
abstract: We report 17 patients (20 hips) in whom metal-on-metal resurfacing had been performed and who presented with various symptoms and a soft-tissue mass which we termed a pseudotumour. Each patient underwent plain radiography and in some, CT, MRI and ultrasonography were also performed. In addition, histological examination of available samples was undertaken. All the patients were women and their presentation was variable. The most common symptom was discomfort in the region of the hip. Other symptoms included spontaneous dislocation, nerve palsy, a noticeable mass or a rash. The common histological features were extensive necrosis and lymphocytic infiltration. To date, 13 of the 20 hips have required revision to a conventional hip replacement. Two are awaiting revision. We estimate that approximately 1% of patients who have a metal-on-metal resurfacing develop a pseudotumour within five years. The cause is unknown and is probably multifactorial. There may be a toxic reaction to an excess of particulate metal wear debris or a hypersensitivity reaction to a normal amount of metal debris. We are concerned that with time the incidence of these pseudotumours may increase. Further investigation is required to define their cause.
authors.affiliation: Nuffield Orthopaedic Centre, Oxford, England.
authors.forename: H
authors.initials: H
authors.lastname: Pandit
authors.forename: S
authors.initials: S
authors.lastname: Glyn-Jones
authors.forename: P
authors.initials: P
authors.lastname: McLardy-Smith
authors.forename: R
authors.initials: R
authors.lastname: Gundle
authors.forename: D
authors.initials: D
authors.lastname: Whitwell
authors.forename: C L M
authors.initials: CL
authors.lastname: Gibbons
authors.forename: S
authors.initials: S
authors.lastname: Ostlere
authors.forename: N
authors.initials: N
authors.lastname: Athanasou
authors.forename: H S
authors.initials: HS
authors.lastname: Gill
authors.forename: D W
authors.initials: DW
authors.lastname: Murray
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000295:instrumentation; D016477:Artifacts; D003238:Connective Tissue / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006104:Granuloma, Plasma Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008670:Metals / Q000009:adverse effects; D008875:Middle Aged; D009336:Necrosis / Q000209:etiology; D010149:Postoperative Pain / Q000209:etiology; D012086:Reoperation; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D008670:Metals