Contribution of serum biomarkers to the diagnosis of invasive candidiasis.
Invasive candidiasis is the most important opportunistic fungal infection, causing high morbidity and mortality. Traditional methods of diagnosis, which include blood culture and biopsy, usually lack both sensitivity and specificity, or become positive late in the course of the infection. Therefore, new nonculture-based methods are being developed. In this review, we will discuss the most recent studies concerning the use of serum biomarkers in the diagnosis of invasive Candida infections.
Laín
Ana
A
Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Apartado 699, E-48080 Bilbao, Vizcaya, Spain. alain@cicbiogune.es
Elguezabal
Natalia
N
Moragues
María Dolores
MD
García-Ruiz
Juan Carlos
JC
del Palacio
Amalia
A
Pontón
José
J
D000818:Animals; D015415:Biomarkers / Q000097:blood*; D002175:Candida; D002177:Candidiasis / Q000097:blood* / Q000175:diagnosis / Q000382:microbiology; D015169:Colony Count, Microbial / Q000379:methods; D006801:Humans; D012680:Sensitivity and Specificity
D015415:Biomarkers