title: Peptide-mediated interactions in biological systems: new discoveries and applications.
abstract: Peptide-mediated interactions play very important roles in cellular processes. Recent years have seen much activity in the discovery of new bioactive peptides, and interactions mediated by protein-peptide binding events. At the same time, computational approaches continue to be developed that allow protein-peptide interactions to be discovered with great accuracy. There are also a growing number of chemicals that can target these interactions with various applications in disease. Both new discoveries and predictions suggest that these protein-peptide interactions play greater roles in cellular processes than previously thought. We propose that projects to uncover the protein-peptide repertoire used in Nature in a systematic way will have numerous applications in molecular biology and medicine.
authors.affiliation: EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Petsalaki
authors.forename: Robert B
authors.initials: RB
authors.lastname: Russell
mesh_terms: D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*
chemical_list: D010455:Peptides; D011506:Proteins