[Implications of the Renin-Angiotensin system in diabetic nephropathy].
In the last decades, the incidence of type 2 diabetes has increased alarmingly worldwide including Mexico, and particularly among Mexican-Americans. The etiology of type 2 diabetes is multiple, in which there is a complex interaction between environmental and genetic risk factors. The kidney is a target organ that is damaged when type 2 diabetes occurs. The genetic predisposition for kidney disease in type 2 diabetes patients is the end result of the cumulative effects of multiple genetic and environmental factors. The components of the renin-angiotensin system and its genetic polymorphisms represent an area of intense research due to its association with kidney disease. Early identification of genetic risk factors for developing kidney disease could lead to timely treatment and may influence the response of the patients to drug therapy and diet recommendations.
Ortega-Pierres
Luz Elena
LE
División de Estudios de Posgrado, Facultad de Ciencias Médicas y Biológicas, Universidad Mihoacana de San Nicoláa de Hidalgo, Morelia, Michoacán, Mexico. jzbmd@prodigy.net.mx
Higareda-Mendoza
Ana Edith
AE
Pardo-Galván
Marco Aurelio
MA
Beltrán-Peña
Elda
E
Gómez-García
Anel
A
Farías-Rodríguez
Víctor Manuel
VM
Alvarez-Aguilar
Cleto
C
D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics; D003928:Diabetic Nephropathies / Q000209:etiology* / Q000235:genetics; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics / Q000502:physiology; D012084:Renin-Angiotensin System / Q000235:genetics / Q000502:physiology*
D007703:Peptidyl-Dipeptidase A