title: Synthesis and herbicidal activities of novel 3-N-substituted amino-6-methyl-4-(3-trifluoromethylphenyl)pyridazine derivatives.
abstract: 4-(3-Trifluoromethylphenyl)pyridazine is a new series of compounds with bleaching and herbicidal activities. Starting from ethyl 2-(3-trifluoromethylphenyl)acetate, an important intermediate 7 was synthesized in five steps with a moderate total yield of 51.5% in a safe and practical way. Twenty-six novel 3-N-substituted amino-6-methyl-4-(3-trifluoromethylphenyl)pyridazine derivatives were synthesized and evaluated through a Spirodela polyrrhiza test and greenhouse test. Some compounds can completely inhibit Chl at 1 microg/mL and exhibit equal or higher herbicidal activities with the commercial bleaching herbicide diflufenican against dicotyledonous plants at a rate of 75 g/ha.
authors.affiliation: State Key Laboratory of Elemento-organic Chemistry, Research Institute of Elemento-organic Chemistry, and Department of Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
authors.forename: Han
authors.initials: H
authors.lastname: Xu
authors.forename: Xu-Hong
authors.initials: XH
authors.lastname: Hu
authors.forename: Xiao-Mao
authors.initials: XM
authors.lastname: Zou
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: You-Quan
authors.initials: YQ
authors.lastname: Zhu
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Fang-Zhong
authors.initials: FZ
authors.lastname: Hu
authors.forename: Hua-Zheng
authors.initials: HZ
authors.lastname: Yang
mesh_terms: D029064:Araceae / Q000187:drug effects; D006540:Herbicides / Q000138:chemical synthesis* / Q000494:pharmacology*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D006540:Herbicides; D011724:Pyridazines