title: [Implications of the Renin-Angiotensin system in diabetic nephropathy].
abstract: In the last decades, the incidence of type 2 diabetes has increased alarmingly worldwide including Mexico, and particularly among Mexican-Americans. The etiology of type 2 diabetes is multiple, in which there is a complex interaction between environmental and genetic risk factors. The kidney is a target organ that is damaged when type 2 diabetes occurs. The genetic predisposition for kidney disease in type 2 diabetes patients is the end result of the cumulative effects of multiple genetic and environmental factors. The components of the renin-angiotensin system and its genetic polymorphisms represent an area of intense research due to its association with kidney disease. Early identification of genetic risk factors for developing kidney disease could lead to timely treatment and may influence the response of the patients to drug therapy and diet recommendations.
authors.affiliation: División de Estudios de Posgrado, Facultad de Ciencias Médicas y Biológicas, Universidad Mihoacana de San Nicoláa de Hidalgo, Morelia, Michoacán, Mexico. jzbmd@prodigy.net.mx
authors.forename: Luz Elena
authors.initials: LE
authors.lastname: Ortega-Pierres
authors.forename: Ana Edith
authors.initials: AE
authors.lastname: Higareda-Mendoza
authors.forename: Marco Aurelio
authors.initials: MA
authors.lastname: Pardo-Galván
authors.forename: Elda
authors.initials: E
authors.lastname: Beltrán-Peña
authors.forename: Anel
authors.initials: A
authors.lastname: Gómez-García
authors.forename: Víctor Manuel
authors.initials: VM
authors.lastname: Farías-Rodríguez
authors.forename: Cleto
authors.initials: C
authors.lastname: Alvarez-Aguilar
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics; D003928:Diabetic Nephropathies / Q000209:etiology* / Q000235:genetics; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics / Q000502:physiology; D012084:Renin-Angiotensin System / Q000235:genetics / Q000502:physiology*
chemical_list: D007703:Peptidyl-Dipeptidase A