Inability to predict mammary tumorigenesis in strain A mice from presence of mammary tumor virus or antigen in the milk.
Strain A females were milked and their milk was tested for mammary tumor virus (MTV) by the hyperplastic alveolar nodule test and for MTV antigen by microimmunodiffusion. An attempt was made to correlate these results with later occurrence of mammary tumors in the females. There was not full agreement between the results of the test for the presence of the MTV and those of the test for MTV antigen, and from these results it was impossible to predict accurately whether a specific female would later develop a tumor. It is concluded that, in this strain, factors other than the MTV can be the determinant in whether the individual female will develop a tumor.
Heston
W E
WE
Laboratory of Biology, National Cancer Institute, Bethesda, Maryland 20014, USA.
Hall
W T
WT
Vlahakis
G
G
Charney
J
J
Moore
D H
DH
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000276:immunology / Q000821:virology*; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology / Q000302:isolation & purification*; D051379:Mice; D008805:Mice, Inbred A; D008892:Milk / Q000821:virology*; D011237:Predictive Value of Tests
D000956:Antigens, Viral