Structure, antimicrobial activity and DNA-binding properties of the cobalt(II)-sparfloxacin complex.
The neutral mononuclear cobalt(II) complex with sparfloxacin has been prepared and characterized with physicochemical, spectroscopic and electrochemical techniques, and molecular mechanics calculations. The interaction of the complex with calf-thymus DNA has been investigated with UV spectroscopy, cyclic voltammetry, and competitive studies with ethidium bromide. The antimicrobial activity of the complex has been tested against three microorganisms.
Efthimiadou
Eleni K
EK
Institute of Physical Chemistry, NCSR Demokritos, GR-15310 Aghia Paraskevi Attikis, Greece.
Karaliota
Alexandra
A
Psomas
George
G
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002417:Cattle; D003035:Cobalt / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D015195:Drug Design; D004996:Ethidium / Q000494:pharmacology; D024841:Fluoroquinolones / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D008956:Models, Chemical; D008968:Molecular Conformation; D011485:Protein Binding; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D003035:Cobalt; D004247:DNA; C427203:calf thymus DNA; D004996:Ethidium; C061363:sparfloxacin