title: Effects of Passiflora edulis flavicarpa on the radiolabeling of blood constituents, morphology of red blood cells and on the biodistribution of sodium pertechnetate in rats.
abstract: The aim of this study was to evaluate possible effects of Passiflora edulis flavicarpa (P. flavicarpa) extract on the labeling of blood constituents with (99m)Tc, on the morphology of red blood cells, and on the biodistribution of sodium pertechnetate (sodium (99m)Tc). Male Wistar rats were treated with either P. flavicarpa extract or 0.9% NaCl. After that, radiolabeling of blood constituents, morphological analysis of red blood cells and biodistribution of sodium (99m)Tc was evaluated. Radiolabeling of blood constituents and shape of red blood cells were not modified, but a significant (p<0.05) alteration of the biodistribution of sodium (99m)Tc was observed after treatment with P. flavicarpa extract. Although our results were obtained with animals, they could contribute to reduce the risk of misdiagnosis and/or repetition of the examinations in nuclear medicine.
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Rio Grande no Norte, Rio Grande do Norte, Brasil.
authors.forename: B M
authors.initials: BM
authors.lastname: Rebello
authors.forename: S R F
authors.initials: SR
authors.lastname: Moreno
authors.forename: C R
authors.initials: CR
authors.lastname: Godinho
authors.forename: R F
authors.initials: RF
authors.lastname: Neves
authors.forename: A S
authors.initials: AS
authors.lastname: Fonseca
authors.forename: M
authors.initials: M
authors.lastname: Bernardo-Filho
authors.forename: A C
authors.initials: AC
authors.lastname: Medeiros
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000166:cytology* / Q000000981:diagnostic imaging* / Q000187:drug effects; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009928:Organ Specificity / Q000187:drug effects; D029598:Passiflora / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D013670:Sodium Pertechnetate Tc 99m / Q000493:pharmacokinetics*; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D010936:Plant Extracts; D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m