title: Comparison of multislice computed tomography with intravascular ultrasound for detection and characterization of coronary artery plaques: a systematic review.
abstract: OBJECTIVE
  Multislice computed tomography (MSCT) is a novel non-invasive test for detection and analysis of coronary artery plaques. A systematic review was conducted of the literature to compare MSCT with IVUS as the reference standard for assessing coronary artery plaques.
  
  
  METHODS
  We performed a literature search in the online database MEDLINE, which was accessed at http://www.pubmed.gov on 9th April 2008.
  
  
  RESULTS
  The search identified 14 studies with 340 patients (mean age 59+/-5 years). The systematic review revealed a sensitivity of MSCT on the lesion level (n=1779 coronary plaques) on the order of 90% (range from 87 to 92%) in comparison to IVUS. Per-segment analysis (n=356) yielded a lower sensitivity of 81-86%. In the per-vessel analysis (n=90), MSCT had a better sensitivity and specificity for the RCA (83-89% and 92-100%) and the LAD (83-87% and 93%) than for the LCX (71-85% and 77-89%), and on the vessel level and the cross-section analysis MSCT was more sensitive for calcified plaques than for non-calcified plaque. It is noteworthy that most studies provide only incomplete data on technical and methodological parameters such as radiation exposure and patient characteristics.
  
  
  CONCLUSIONS
  MSCT is an accurate and reliable test for detection of coronary artery plaques in comparison to IVUS with limitations in regards to the LCX and non-calcified plaques. Studies published thus far are limited by the sample sizes and methodological quality issues.
authors.affiliation: Department of Radiology, Charité, Medical School, Humboldt-Universität zu Berlin, Germany.
authors.forename: Ivonne
authors.initials: I
authors.lastname: Springer
authors.forename: Marc
authors.initials: M
authors.lastname: Dewey
mesh_terms: D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000175:diagnosis*; D004452:Echocardiography / Q000379:methods*; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods*