Pregnancy outcome of women who developed proteinuria in the absence of hypertension after mid-gestation.
OBJECTIVE
To characterize the clinical features of women with singleton pregnancies who develop proteinuria in the absence of hypertension after mid-gestation.


METHODS
Seventy-nine women who developed proteinuria and/or hypertension at and after 20 weeks of gestation were reviewed, focusing on the gestational week at which significant proteinuria (>0.3 g/day) and/or hypertension developed.


RESULTS
Thirty-seven (47%) women exhibited new-onset proteinuria (>0.3 g/day) in the absence of hypertension, 33 (42%) exhibited new-onset hypertension in the absence of proteinuria, and 9 (11%) exhibited both proteinuria and hypertension. Nineteen (51%) of 37 women who exhibited new proteinuria in the absence of hypertension and 5 (15%) of 33 women who exhibited new hypertension in the absence of proteinuria progressed to preeclampsia (P=0.002). Among women who exhibited new proteinuria, 10 (77%) out of 13 women and 9 (38%) out of 24 women who developed proteinuria at <32 weeks and >or=32 weeks, respectively, progressed to preeclampsia (P=0.022).


CONCLUSIONS
Women with new-onset proteinuria in the absence of hypertension may be more likely to progress to preeclampsia than women with a presumptive diagnosis of gestational hypertension, and the likelihood of progression may be significantly greater among women with earlier presentation.
Morikawa
Mamoru
M
Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo, Japan. mmamoru@med.hokudai.ac.jp
Yamada
Takashi
T
Yamada
Takahiro
T
Cho
Kazutoshi
K
Yamada
Hideto
H
Sakuragi
Noriaki
N
Minakami
Hisanori
H
D000328:Adult; D018450:Disease Progression; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000175:diagnosis*; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011507:Proteinuria / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D012189:Retrospective Studies; D055815:Young Adult