The triterpenoid lupeol attenuates allergic airway inflammation in a murine model.
Asthma is a chronic inflammatory disease of the airways associated with a Th2 immune response. Despite their side effects, corticosteroids are the most used and effective drugs for treatment of asthma. In this work we investigated the efficacy of lupeol, a triterpenoid isolated from Lonchocarpus araripensis [corrected] Benth. (Fabaceae), in the treatment of bronchial asthma in BALB/c mice immunized with ovalbumin. Administration of lupeol caused the reduction of cellularity and eosinophils in the bronchoalveolar lavage fluid. Treatment with lupeol also reduced the production of mucus and overall inflammation in the lung. Levels of Type II cytokines IL-4, IL-5 and IL-13 were significantly reduced in mice treated with lupeol, an effect that was similar to that observed in dexamethasone-treated mice. In contrast, IgE production was not significantly altered after treatment with lupeol. In conclusion, our results demonstrate that lupeol attenuates the alterations' characteristics of allergic airway inflammation. The investigation of the mechanisms of action of this molecule may contribute for the development of new drugs for the treatment of asthma.
Vasconcelos
J F
JF
Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, Brazil.
Teixeira
M M
MM
Barbosa-Filho
J M
JM
Lúcio
A S S C
AS
Almeida
J R G S
JR
de Queiroz
L P
LP
Ribeiro-Dos-Santos
R
R
Soares
M B P
MB
D000542:Alveolitis, Extrinsic Allergic / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000627:therapeutic use*; D000906:Antibodies / Q000032:analysis / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D016207:Cytokines / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D053978:Pentacyclic Triterpenes; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects; D014315:Triterpenes / Q000302:isolation & purification / Q000627:therapeutic use*; D000094042:Lupanes
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000906:Antibodies; D016207:Cytokines; D010047:Ovalbumin; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C010480:lupeol; D000094042:Lupanes