[Expression of survivin and its correlation with p53 and bcl-2 expression in laryngeal and hypopharyngeal cancer].
OBJECTIVE
To investigate the expression of survivin in the laryngeal and hypopharyngeal squamous cell carcinoma, and to elucidate the correlation between the expression of survivin and other two proteins: p53 and bcl-2.


METHODS
Immunohistochemistry analysis was performed in paraffin-embedded tissue section of 40 laryngeal and hypopharyngeal cancer and 10 polyp of vocal cord.


RESULTS
Expression rates of survivin, p53 and bcl-2 were 70. 0%, 57.5% and 37.5%, respectively, in cancer tissues, whereas none of the three proteins were detected in polyps, the statistic analysis showed that the difference was significant (P<0.05). An increased expression of survivin paralleled with the progression of histologic differentiation, increasing grade of clinical stages and lymph node metastasis. While bcl-2 expression showed reverse association to TNM stages, no correlation with other clinical and pathologic parameters were observed . p53 staining in this experiment bear any relationship with clinical or pathological variables. There was significant statistical correlation between survivin and p53 expression, but no such correlation was found between survivin and bcl-2 expression.


CONCLUSIONS
These results indicate that survivin and p53 expression might play synergetic role in the carcinogenesis and progression of laryngeal and hypopharyngeal cancer. Though being as anti-apoptotic protein, survivin and bcl-2 seem to have different effects on the occurrence and development of laryngeal and hypopharyngeal cancer.
Sun
Min
M
Department of Otolaryngology-Head and Neck Surgery, Peking University First Hospital, Beijing, 100034, China.
Qin
Yong
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D000077022:Survivin; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D000077022:Survivin; D016159:Tumor Suppressor Protein p53