[Recurrent rhinitis and pulmonary infections revealing celiac disease: case report].
Celiac disease is associated with a number of extra-gastrointestinal features such as hepatitis, arthralgia, and recurrent foetal loss. However respiratory involvement is an extremely rare disorder. We report a case of celiac disease revealed by bronchiectasia in a 39-year-old man. The patient reported a history of recurrent pulmonary infections and intermittent intestinal symptoms in childhood. Wegner granulomatosis was initially suspected because of rhinopulmonary involvement. Serum's patient was tested for ANCA and anti-tissue antibodies. The latest test was performed on histological sections from rat and revealed the presence of anti-reticulin antibodies. Further testing, for anti-tissue transglutaminase and anti-endomysium antibodies, revealed positive results. Celiac disease was confirmed by histological examination of intestinal biopsy. Pulmonary symptoms were improved on a gluten free diet suggesting a causal relationship between celiac disease and respiratory symptoms.
Kallel-Sellami
M
M
Laboratoire d'immunologie, Hôpital La Rabta, Tunis, Tunisia.
Laadhar
L
L
Zitouni
M
M
Makni
S
S
D000328:Adult; D000906:Antibodies / Q000097:blood; D002446:Celiac Disease / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000209:etiology*; D012220:Rhinitis / Q000209:etiology*; D011503:Transglutaminases / Q000276:immunology
D000906:Antibodies; D011503:Transglutaminases