[Alpha-tocopherol and alpha-lipoic acid. An antioxidant synergy with potential for preventive medicine].
Reactive oxygen species (ROS) have been involved in the induction and progression of damage of many human disorders, such as: heart infarction, cerebral ischemia, diabetic neuropathy, Alzheimer's disease, etc. In several studies, the synergism between alpha-lipoic acid and vitamin E has been described and potent antioxidant effects can be obtained when both antioxidants are simultaneously used. This review highlights recent findings showing that the combination of alpha-lipoic acid plus vitamin E effectively reduces oxidative damage in brain and cardiac ischemia as well as in other pathological events related to ROS increasing. These antioxidants are present in a broad variety of foods, are also available in several dietary supplements and their side effects are very rare. Therefore, alpha-lipoic acid and vitamin E may play an important role in clinical preventive medicine and human nutrition.
González-Pérez
Oscar
O
Laboratorio de Neurociencias, Facultad de Psicología, Universidad de Colima. osglez@ucol.mx
Moy-López
Norma Angélica
NA
Guzmán-Muñiz
Jorge
J
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004357:Drug Synergism; D006801:Humans; D011315:Preventive Medicine; D008063:Thioctic Acid / Q000627:therapeutic use*; D024502:alpha-Tocopherol / Q000627:therapeutic use*
D000975:Antioxidants; D008063:Thioctic Acid; D024502:alpha-Tocopherol