Poly (vinyl alcohol) hydrogels for pH dependent colon targeted drug delivery.
Oral drug administration is convenient with pH dependent drug delivery system since the drug has to pass through different pH environments in gastro intestinal (GI) tract. The pH dependent swelling/shrinking behavior of hydrogel drug carrier controls the drug release without affecting the function of drug. pH dependent hydrogels of poly (vinyl alcohol) (PVA) were prepared by cross linking with maleic acid (MA). The hydrogels were characterized by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, DSC, porosimetry, SEM, TEM, biocompatibility study and by measuring their swelling behavior in water, simulated gastric fluid (SGF) and intestinal fluid (SIF). Swelling of the hydrogels was found to be highest in SIF (pH: 7.5) and lowest in SGF (pH: 1.2) resembling that required in colon targeted drug delivery systems. Since the swelling behavior of the gel is pH dependent, these hydrogels were studied for colon targeted drug delivery in an in-vitro set-up resembling the condition of GI tract. The ratio of PVA and MA in the hydrogel was varied to study the effect on the drug diffusion rate. For drug delivery study, vitamin B12 and salicylic acid were used as model drugs. The hydrogel, loaded with model drugs vitamin B12 and salicylic acid also demonstrated colon specific drug release with a relatively higher drug release in SIF (pH: 7.5) than that in SGF (pH: 1.2).
Basak
Piyali
P
Materials Science Centre, Indian Institute of Technology, Kharagpur 721302, India. piyali_basak@yahoo.com
Adhikari
Basudam
B
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002478:Cells, Cultured; D003106:Colon / Q000187:drug effects*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000494:pharmacology; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D005765:Gastrointestinal Agents / Q000008:administration & dosage* / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D051379:Mice; D008954:Models, Biological; D011142:Polyvinyl Alcohol / Q000138:chemical synthesis* / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000378:metabolism
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005765:Gastrointestinal Agents; C062364:polyvinyl alcohol hydrogel; D014867:Water; D011142:Polyvinyl Alcohol