title: MRI methodological development of intervertebral disc degeneration: a rabbit in vivo study at 9.4 T.
abstract: Intervertebral disc (IVD) degeneration is a complex process characterized by biochemical and structural changes in both the nucleus pulposus and the anulus fibrosus. In this study, we were able to obtain in vivo magnetic resonance (MR) images of the rabbit spine, with several MR imaging (MRI) contrasts (rho, T(1) and T(2)). We quantified several parameters (T(2), apparent diffusion coefficient, disc height and area) to differentiate between healthy and degenerative IVDs and to characterize the degeneration process. To our knowledge, there has not been any previous in vivo study of rabbit IVDs at high-field MRI (9.4 T). A custom radio frequency (RF) coil for 9.4 T was designed to match rabbit IVD morphology, to study the degeneration in vivo on a model of human lumbar disease. Our new probe, a custom half-birdcage-type coil, obtains the necessary exploration depth while meeting the requirements for signal homogeneity and sensitivity of the study. This design addresses some of the difficulties with constructing RF coils at high field strengths.
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR4301, 45071 Orléans Cedex 2, France. noury@cnrs-orleans.fr
authors.forename: Fanny
authors.initials: F
authors.lastname: Noury
authors.forename: Joël
authors.initials: J
authors.lastname: Mispelter
authors.forename: Frédéric
authors.initials: F
authors.lastname: Szeremeta
authors.forename: Sandra
authors.initials: S
authors.lastname: Même
authors.forename: Bich-Thuy
authors.initials: BT
authors.lastname: Doan
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Beloeil
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007091:Image Processing, Computer-Assisted; D007405:Intervertebral Disc Displacement / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods; D019047:Phantoms, Imaging; D011817:Rabbits