Experimental study of [99mTc(PNP5) (DBODC)]+ as a new myocardial perfusion imaging agent.
OBJECTIVE
This study was aimed to compare the properties of [(99m)Tc(PNP5)(DBODC)]+ with (99m)Tc-MIBI in normal swine and in canine models of myocardial ischemia.


METHODS
Seven anesthetized swine were injected intravenously with [(99m)Tc(PNP5)(DBODC)]+. Serial planar images were acquired meanwhile. Twelve adult dogs were studied. A critical stenosis of left anterior descending artery was produced. [(99m)Tc(PNP5)(DBODC)]+ or (99m)Tc-MIBI (randomly) was injected intravenously at the end of 3 min of adenosine infusion. The occluder was released after adenosine infusion. Myocardial SPECT imaging was obtained at 30, 60, 90 and 180 min, respectively, after tracer injection. Rest myocardial SPECT imaging was acquired on the next day.


RESULTS
Blood disappearance of [(99m)Tc(PNP5)(DBODC)]+ was biexponential with an initial half-time of 2.97 +/- 0.48 min and a late half-time of 52.49 +/- 19.49 min. Myocardial [(99m)Tc(PNP5)(DBODC)]+ uptake was similar to (99m)Tc-MIBI. Heart-to-liver ratio of [(99m)Tc(PNP5)(DBODC)]+ was significantly higher than that of (99m)Tc-MIBI (0.99 +/- 0.03 vs. 0.46 +/- 0.10, p < 0.05) 30 min after injection. In canine models of myocardial ischemia, image quality of [(99m)Tc(PNP5)(DBODC)]+ was better than (99m)Tc-MIBI. Segments with perfusion defects by [(99m)Tc(PNP5)(DBODC)]+ was 3.60 +/- 1.52 and 4.25 +/- 0.96 by (99m)Tc-MIBI (p = n.s.).


CONCLUSIONS
[(99m)Tc(PNP5)(DBODC)]+ seems to be a promising new myocardial perfusion imaging agent.
Zhang
Wan-Chun
WC
Department of Nuclear Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Bei Li Shi Lu, Beijing, China.
Fang
Wei
W
Li
Bin
B
Wang
Xue-Bin
XB
He
Zuo-Xiang
ZX
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D006321:Heart / Q000000981:diagnostic imaging*; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging*; D009943:Organophosphorus Compounds / Q000493:pharmacokinetics; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D013552:Swine; D013556:Swine, Miniature; D017256:Technetium Tc 99m Sestamibi / Q000493:pharmacokinetics; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
C496311:99mTc-N-DBODC5; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D017256:Technetium Tc 99m Sestamibi