title: Reversal of optic disc cupping in glaucoma.
abstract: OBJECTIVE
  To study whether reversal of optic disc cupping after intraocular pressure (IOP) reduction is related to risk of glaucoma progression.
  
  
  METHODS
  In this prospective follow-up study, where 51 patients with exfoliation glaucoma and five with ocular hypertension combined with exfoliation syndrome were followed for 6 years after IOP reduction, 24 showed progression of glaucoma in visual fields or optic nerve head (ONH) stereophotographs. ONH topography was measured with the Heidelberg Retina Tomograph (HRT). A decrease in HRT parameter cup volume of more than 5% was considered cup reversal. Multiple logistic regression was used to model progression of glaucoma.
  
  
  RESULTS
  Cup reversal (OR 0.226; 95% CI 0.055 to 0.918, p = 0.037), final IOP (OR 1.216; 95% CI 1.000 to 1.479, p = 0.050) and visual field mean defect at entry (OR 1.158; 95% CI 1.034 to 1.296, p = 0.011) were associated with progression. IOP change from study entry to 6-year control visit was not associated with progression (OR 0.964, 95% CI 0.850 to 1.092, p = 0.56).
  
  
  CONCLUSIONS
  Cup reversal seemed to be an independent protective factor for progression of glaucoma.
authors.affiliation: Helsinki University Eye Hospital, Haartmaninkatu 4 C, PO Box 220, 00029 Hus, Finland. mika.harju@aad.fi
authors.forename: M
authors.initials: M
authors.lastname: Harju
authors.forename: J
authors.initials: J
authors.lastname: Saari
authors.forename: L
authors.initials: L
authors.lastname: Kurvinen
authors.forename: E
authors.initials: E
authors.lastname: Vesti
mesh_terms: D018450:Disease Progression; D004812:Epidemiologic Methods; D017889:Exfoliation Syndrome / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D005901:Glaucoma / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D009798:Ocular Hypertension / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D009898:Optic Disk / Q000473:pathology*; D011379:Prognosis; D014054:Tomography; D014794:Visual Fields