Mid-infrared reflectivity of experimental atheromas.
We report that the pathologic components present within the atheromatous plaques of ApoE knock-out mice can reflect significant amounts of mid-infrared (mid-IR) light. Furthermore, the reflected light spectra contained the unique signatures of a variety of biologic features including those found in unstable or "vulnerable" plaque. This discovery may represent a unique opportunity to develop a new intravascular diagnostic modality that can detect and characterize sites of atherosclerosis.
Holman
Hoi-Ying N
HY
University of California, Berkeley, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. hyholman@lbl.gov
Bjornstad
Kathy A
KA
Martin
Michael C
MC
McKinney
Wayne R
WR
Blakely
Eleanor A
EA
Blankenberg
Francis G
FG
D000818:Animals; D001018:Aortic Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism; D050197:Atherosclerosis / Q000175:diagnosis* / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D007259:Infrared Rays; D051379:Mice; D018345:Mice, Knockout; D010783:Photometry / Q000379:methods*; D012680:Sensitivity and Specificity
D001057:Apolipoproteins E