title: [Weaning from the ventilator modalities and consequences].
abstract: Only few studies have focused on the issues raised by discontinuing sedation in ICU patients. Several lines of evidence allow defining the risk factors for the occurrence of a weaning syndrome due to discontinuation of sedatives and analgesics in ICU patients. These primarily include a prolonged (more than seven days) period of continuous intravenous administration of high doses of hypnotics and opioids. Weaning from sedation is tightly linked to weaning from the ventilator and this area should be the target of research work in the near future.
authors.affiliation: Service d'anesthésie-réanimation-Smur, pôle urgences proximité-réanimations maternité, hôpital Beaujon, 92110 Clichy, France. jean.mantz@bjn.ap-hop-paris.fr
authors.forename: J
authors.initials: J
authors.lastname: Mantz
mesh_terms: D017109:Akathisia, Drug-Induced / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D003072:Cognition Disorders / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D015897:Comorbidity; D016292:Procedural Sedation / Q000379:methods*; D003422:Critical Care / Q000379:methods*; D004359:Drug Therapy, Combination; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008991:Monitoring, Physiologic / Q000379:methods; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D012893:Sleep Wake Disorders / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000517:prevention & control; D019966:Substance-Related Disorders / Q000150:complications; D015300:Ventilator Weaning / Q000009:adverse effects / Q000379:methods*
chemical_list: D000700:Analgesics; D006993:Hypnotics and Sedatives