[Platinum salts hypersensitivity].
It become usually after 4 to 8 courses of treatment. A long platin free interval is an increased risk of reaction. Clinical manifestations are various and can be separate in light to mild or severe reactions. Diagnose is retrospective with results of skin test. Prick test and IDR (using sequentially diluted platin salt and delayed reading) are the most available, essentially in case of acute reaction (<2h after injection of platin salt). IDR realized 30 min before injection of platin salt can be a good predictive test of hypersensitivity reaction. Management of this adverse effect depends on clinical manifestation: light to mild: careful re-introduction with a desensitization protocol; severe: no re-introduction. If it's necessary, careful replacement by another platin salt can be possible, eventually in accordance with results of IDR to all platinum salt.
Couraud
S
S
Service de radiothérapie et oncologie, Centre hospitalier Lyon Sud, 165 Chemin du Grand-Revoyet, Pierre-Bénite cedex, France.
Planus
C
C
Rioufol
C
C
Mornex
F
F
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000737:chemistry; D016190:Carboplatin / Q000009:adverse effects / Q000737:chemistry; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000009:adverse effects / Q000737:chemistry; D000077150:Oxaliplatin; D017671:Platinum Compounds / Q000009:adverse effects*; D012307:Risk Factors; D012882:Skin Tests
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D017671:Platinum Compounds; D000077150:Oxaliplatin; D016190:Carboplatin