Opposing roles for glypicans in Hedgehog signalling.
Glypican members of the heparan sulphate proteoglycan family regulate several developmental signalling pathways, such as those involving Hedgehog, Wnt, BMP and FGF. Two studies reveal opposite effects of glypicans on Hedgehog signalling and show how their core protein domains and GPI anchor contribute to their versatile biological functions.
Yan
Dong
D
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Lin
Xinhua
X
D000818:Animals; D019521:Body Patterning; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000196:embryology; D053673:Glypicans / Q000737:chemistry / Q000378:metabolism*; D053823:Hedgehog Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D015398:Signal Transduction / Q000502:physiology*
D053673:Glypicans; D053823:Hedgehog Proteins