title: Enantioselective synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed cyanoamidation.
abstract: The first enantioselective cyanoamidation of olefins provides quick access to a variety of 3,3-disubstituted oxindoles. The combination of Pd(dba)2, an optically active phosphoramidite, and N, N-dimethylpropylene urea (DMPU) in decalin were found to be the best conditions.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
authors.forename: Yoshizumi
authors.initials: Y
authors.lastname: Yasui
authors.forename: Haruhi
authors.initials: H
authors.lastname: Kamisaki
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Takemoto
mesh_terms: D000586:Amination; D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D000078183:Oxindoles; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000814:Aniline Compounds; D007211:Indoles; D009570:Nitriles; D000078183:Oxindoles; C022960:2-oxindole; D010165:Palladium