title: Coronary lesion type, location, and characteristics of acute ST elevation myocardial infarction in young adults under 35 years of age.
abstract: OBJECTIVE
  In the present study, we attempted to analyze the coronary artery lesion characteristics of acute ST elevation myocardial infarction (STEMI) in young patients (aged less than 35 years).
  
  
  METHODS
  We retrospectively surveyed 25 038 coronary angiography procedures, which were carried out at The Baskent University Adana Hospital from 1998 to present, to discover acute STEMI in young patients. We studied clinical risk factors and angiographic characteristics in 42 consecutive patients who underwent primary coronary angiography for acute STEMI. Control group (n=42) had no history of coronary artery disease and had angiographically proven normal coronary arteries. All patients were under 35 years of age. Angiographic features for STEMI group were collected and both groups were compared for coronary risk factors.
  
  
  RESULTS
  Male sex was more prevalent in acute STEMI group when compared with control participants (83 vs. 59%, respectively; P=0.01). A significant difference was found in cigarette smoking (62 vs. 36%, respectively; P=0.007) and family history (33 vs. 16%, respectively; P=0.03) between the two groups. No statistical significance was observed between the groups in terms of hypertension, diabetes mellitus, total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels. Mean high-density lipoprotein cholesterol level was 33+/-8 mg/dl in STEMI group and 39+/-12 mg/dl in control participants (P=0.02). Young patients with acute STEMI showed a preponderance of single-vessel disease (69%) and acute anterior STEMI (60%) owing to occluded left anterior descending artery (P<0.001).
  
  
  CONCLUSIONS
  We observed risk factors such as family history, smoking, and low high-density lipoprotein cholesterol levels in young adults. Acute anterior STEMI owing to occluded left anterior descending artery was more frequent. Coronary atherosclerosis was characterized by higher presence of type B and proximal lesions. The handling selection was percutaneous coronary intervention in more than half of the patients.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Baskent University, Ankara, Turkey. kardiyoloji@yahoo.com
authors.forename: Abdurrahman Yucel
authors.initials: AY
authors.lastname: Colkesen
authors.forename: Tayfun
authors.initials: T
authors.lastname: Acil
authors.forename: Senol
authors.initials: S
authors.lastname: Demircan
authors.forename: Alpay T
authors.initials: AT
authors.lastname: Sezgin
authors.forename: Haldun
authors.initials: H
authors.lastname: Muderrisoglu
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015906:Angioplasty, Balloon, Coronary; D016022:Case-Control Studies; D017023:Coronary Angiography / Q000706:statistics & numerical data*; D003324:Coronary Artery Disease; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors