Inhibition of adipogenesis: a new job for the ER Ca2+ pool.
Adipogenesis is the process of differentiation of adipocytes from mesenchymal multipotent cells through adipocyte precursors. In this issue, a study by the groups of Opas and Michalak (Szabo, E., Y. Qiu, S. Baksh, M. Michalak, and M. Opas. 2008. J. Cell. Biol. 182:103-116) demonstrates that this process is repressed by increasing intracellular Ca(2+), which, in turn, is dependent on the expression of calreticulin, the major Ca(2+)-binding protein of the endoplasmic reticulum lumen.
Meldolesi
Jacopo
J
Vita-Salute San Raffaele University and San Raffaele Institute, 20132 Milan, Italy. meldolesi.jacopo@hsr.it
D017667:Adipocytes / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D050156:Adipogenesis; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D037282:Calreticulin / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D051379:Mice; D047495:PPAR gamma / Q000378:metabolism; D021381:Protein Transport
D037282:Calreticulin; D047495:PPAR gamma; D002118:Calcium