title: The value of local botulinum toxin A injection in the treatment of the pain of aphthous ulcer.
abstract: To determine the effectiveness of botulinum toxin type A to reduce pain of recurrent aphthous ulcer, a single blinded placebo controlled trial of botulinum toxin A injection was performed. A total of 70 patients were enrolled and randomly received a botulinum toxin type A 1 unit or placebo. The patients were asked to note the level of pain on the visual analogue scale for 6 days. They also had to record any eventual side effects or recurrence for 6 months. More patients quickly recovered following Botulinum toxin type A injection than placebo; they would feel almost no pain after about 3 days. Botulinum toxin type A exhibits quick pain treatment effect following injection on aphthous ulcer. The author also believes that it can prevent recurrence for at least 6 months after injection.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, College of Medicine, Inha University, 3-Ga Shinheung-dong, Jung-Gu, Incheon, South Korea. mansatong2@naver.com
authors.forename: Tae Yong
authors.initials: TY
authors.lastname: Yang
authors.forename: Tae Young
authors.initials: TY
authors.lastname: Jang
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D010146:Pain / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D010147:Pain Measurement; D011446:Prospective Studies; D012720:Severity of Illness Index; D016037:Single-Blind Method; D013281:Stomatitis, Aphthous / Q000150:complications*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A