Fifteen-year follow-up of transplantation of a cadaveric polycystic kidney: a case report.
BACKGROUND
Kidneys from donors affected by autosomal-dominant polycystic kidney disease (ADPKD) are in general considered unsuitable for transplantation. To the best of our knowledge, only 12 cases of ADPKD transplanted renal units have been reported in the English literature; most have only short-term follow-up.


METHODS
We provide a review of these patients and share our experience with an ADPKD patient who received a 21-year-old deceased donor ADPKD-affected renal transplant and has been closely followed for 15 years. Based on the current literature, this report is the longest follow-up of a ADPKD donor transplant.


RESULTS
Over the 15-year follow-up period, there have been no complications related to the ADPKD-affected donor kidney, including three kidney transplant biopsies. The graft continues to function well with the serum creatinine currently 1.2 mg/dL. Serial axial imaging has demonstrated that the cystic disease has slowly progressed in the donor renal unit, with the largest cyst having only increasing from 1.2 to 2.9 cm in diameter. Metachronous, bilateral laparoscopic nephrectomies of the native kidneys were performed owing to intractable pain from cystic enlargement.


CONCLUSIONS
Normal functioning deceased donor kidneys that show signs of early ADPKD should be considered acceptable for donation in select cases. These organs provide the recipient a safe, reasonable period of graft survival and have not been shown to cause adverse effects.
Eng
M K
MK
Section of Urology, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA. meng@surgery.bsd.uchicago.edu
Zorn
K C
KC
Harland
R C
RC
Bernstein
A J
AJ
Katz
M
M
Shikanov
S
S
Shalhav
A L
AL
D000328:Adult; D002102:Cadaver; D003404:Creatinine / Q000097:blood; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D016891:Polycystic Kidney, Autosomal Dominant / Q000601:surgery*; D011183:Postoperative Complications / Q000473:pathology; D014019:Tissue Donors
D003404:Creatinine