Anaplastic large cell lymphoma associated with a breast implant capsule: a case report and review of the literature.
Primary lymphomas of the breast are rare and predominately of B-cell phenotype. Anaplastic large cell lymphoma is a T-cell lymphoma that accounts for only 3% of all non-Hodgkin lymphomas. We present a rare case of primary anaplastic large cell lymphoma of the breast in association with a silicone breast implant capsule in a healthy 40-year-old woman. The patient had bilateral breast implants placed at 21 years of age and presented with painful bilateral breast contractures and associated breast asymmetry. Histology, immunohistochemistry, and T-cell gene rearrangement studies were supportive of a CD 30-positive ALK-1 negative anaplastic large cell lymphoma. This case represents the 14th reported case of primary breast lymphoma in association with breast prosthesis. Of interest is that 11 of these cases were T-cell lymphomas with 8 specifically of the CD30-positive anaplastic large cell lymphoma type. This rare case highlights the importance of histologic examination of breast capsule specimens.
Wong
Anna K
AK
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. anna.wong@cshs.org
Lopategui
Jean
J
Clancy
Sharon
S
Kulber
David
D
Bose
Shikha
S
D000328:Adult; D019928:Breast Implantation; D018427:Breast Implants / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D020878:Device Removal; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis; D017728:Lymphoma, Large-Cell, Anaplastic / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D011474:Prosthesis Design; D020034:Silicone Gels
D007143:Immunoglobulin Heavy Chains; D017730:Ki-1 Antigen; D020034:Silicone Gels