Accumulated cytokines in stored autologous blood do not cause febrile nonhemolytic transfusion reactions.
Accumulated inflammatory cytokines are considered to be a cause of febrile nonhemolytic transfusion reactions (FNHTRs) of platelet transfusions. Inflammatory cytokines have been found in red cell components stored at 4 degrees C; however, their relationship to FNHTRs has not been clearly demonstrated following red cell transfusions. We measured cytokine levels in stored blood, and determined whether inflammatory marker concentrations were elevated in subjects infused with autologous blood stored for 5 weeks. In conclusion, cytokines accumulated in blood stored at 4 degrees C, but their increases were small. No changes were seen in recipients' inflammatory markers after blood transfusion. Our results indicate that cytokines in stored autologous blood are not responsible for FNHTRs.
Tasaki
Tetsunori
T
Blood Transfusion Service, Tokyo Jikei University Hospital, 3-19-18 Nishi-Shimbashi, Minato-ku, Tokyo, Japan. ttasaki@jikei.ac.jp
Gotoh
Kenji
K
Fujii
Kieko
K
Sasaki
Sakiko
S
Satoh
Shyukuko
S
Takadate
Junko
J
Otsubo
Hiroko
H
Hoshi
Yasutaka
Y
D000328:Adult; D000368:Aged; D001804:Blood Transfusion, Autologous; D006348:Cardiac Surgical Procedures; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion; D011300:Preoperative Care; D012034:Refrigeration; D013997:Time Factors
D016207:Cytokines; D018836:Inflammation Mediators