Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.
The aporphine alkaloid glaucine has been converted into 3-aminomethylglaucine and its free amino group has been linked to cinnamic, ferulic, sinapic, o-, and p-coumaric acids. The antioxidative potential of the synthesized amides was studied against DPPH(*) test. All of the tested compounds demonstrated higher radical scavenging activity than glaucine and 3-aminomethylglaucine, and lower antioxidative effect than the free hydroxycinnamic acids. The newly synthesized compounds were tested in vitro for antiviral activity against viruses belonging to different taxonomic groups.
Spasova
Maya
M
South-West University, Neofit Rilski, Blagoevgrad 2700, Bulgaria.
Philipov
Stefan
S
Nikolaeva-Glomb
L
L
Galabov
A S
AS
Milkova
Ts
Ts
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D001060:Aporphines / Q000737:chemistry*; D002460:Cell Line; D002934:Cinnamates / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry*; D004285:Dogs; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014780:Viruses / Q000187:drug effects
D000970:Antineoplastic Agents; D000975:Antioxidants; D000998:Antiviral Agents; D001060:Aporphines; D002934:Cinnamates; D003373:Coumaric Acids; C005004:glaucine