title: New opportunities with the Duff reaction.
abstract: The Duff reaction (HMTA, AcOH or TFA) was studied on substituted [6 + 5] heterocyclic compounds. This reaction provides a useful route to aldehydes for compounds bearing sensitive amide functions. It gives also access to tricyclic lactams of potential biological interest. The formation of an aminomethyl intermediate in the Duff reaction mechanism is unequivocally demonstrated.
authors.affiliation: E.A.4231, Faculté de Pharmacie, 28 place Henri Dunant, B.P. 38, 63001 Clermont-Ferrand Cedex 1, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Masurier
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Moreau
authors.forename: Claire
authors.initials: C
authors.lastname: Lartigue
authors.forename: Vincent
authors.initials: V
authors.lastname: Gaumet
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Chezal
authors.forename: Annie
authors.initials: A
authors.lastname: Heitz
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Teulade
authors.forename: Olivier
authors.initials: O
authors.lastname: Chavignon
mesh_terms: D006571:Heterocyclic Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D006571:Heterocyclic Compounds