title: [The pathophysiological analysis of cerebrolysin therapy of children with mental developmental delay caused by ecological factors].
abstract: The treatment with cerebrolysin combined with psychological correction was conducted in 24 children, aged 4-6 years, with mental developmental delay. The effect of this drug was compared to placebo (20 patients with mental development delay) and control groups (35 healthy children). After cerebrolysin therapy effect of cerebrolysin (0,1 mg/1kg of body mass during 42 day) was assessed using neuropsychological data and a set of different pathophysiological indices which reflected the biochemical, immunological and neurophysiological status of patients. After cerebrolysin therapy significant improvement of the mental state, including preconditions of intellect, and motor functions specific for mental development delay was found. These changes were correlated with the positive dynamics of some indices - lipid peroxidation, immune status, hormonal shifts and parameters of neurodegeneration-neuroprotection processes.
authors.forename: N V
authors.initials: NV
authors.lastname: Govorin
authors.forename: T P
authors.initials: TP
authors.lastname: Zlova
authors.forename: V V
authors.initials: VV
authors.lastname: Akhmetova
authors.forename: O A
authors.initials: OA
authors.lastname: Tarasova
mesh_terms: D000596:Amino Acids / Q000627:therapeutic use*; D001921:Brain / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004781:Environmental Exposure / Q000009:adverse effects*; D005500:Follow-Up Studies; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D008603:Mental Health; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000596:Amino Acids; D018696:Neuroprotective Agents; C006952:cerebrolysin