title: Do two current canine parvovirus type 2 and 2b vaccines provide protection against the new type 2c variant?
abstract: Three groups (n=9 or 10) of 12-week-old canine parvovirus type 2 (CPV-2) antibody-negative puppies were vaccinated: one group with a product containing modified-live CPV-2b (Galaxy DA2PPv; Schering-Plough Animal Health), one group with a product containing modified-live CPV-2 (Continuum DAP, Intervet), and one group (controls) with sterile saline. All puppies receiving CPV-2 and CPV-2b vaccines developed antibody as determined by the hemagglutination inhibition assay. All groups of puppies were challenged with a combination of virulent CPV-2b and CPV-2c 5 weeks after vaccination. All puppies in the CPV-2 and CPV-2b vaccinated groups were protected from disease, whereas all control group puppies developed disease and 50% died or were euthanized. This study demonstrated that the CPV-2 and CPV-2b vaccine components of the Continuum DAP and Galaxy DA2PPv products, respectively, provided protection against the CPV-2b virus and also provided complete protection against the new CPV-2c variant.
authors.affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706-1102, USA.
authors.forename: Laurie J
authors.initials: LJ
authors.lastname: Larson
authors.forename: R D
authors.initials: RD
authors.lastname: Schultz
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000097:blood; D004283:Dog Diseases / Q000473:pathology / Q000517:prevention & control*; D004285:Dogs; D005243:Feces / Q000821:virology; D005260:Female; D008297:Male; D010322:Parvoviridae Infections / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D017993:Parvovirus, Canine / Q000145:classification / Q000276:immunology*; D012703:Serotyping / Q000662:veterinary; D016896:Treatment Outcome; D014611:Vaccination / Q000662:veterinary*; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology; D017201:Virus Shedding
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines