title: Possible additional value of 18FDG-PET in managing pancreas intraductal papillary mucinous neoplasms: preliminary results.
abstract: Although some clinical and radiological features may predict malignancy presence in intraductal papillary mucinous pancreas neoplasms, preoperative diagnosis remains difficult. In this study we present 7 patients with Intraductal Papillary Mucinous Neoplasm (IPMN) studied both with 18FDG-PET and magnetic resonance cholangiopancreatography (MRCP). A focal hypermetabolism was documented in 2 patients (the standardized uptake value in the neoplastic foci was 6.7 and 9), while absence of FDG uptake in the neoplasm area was recorded in the remaining 5 cases. Mean follow-up was 27 months (range 21-34). The final judgement was benign IPMN in 5 cases and malignant IPMN in 2. PET scan always correctly predicted the presence or absence of malignancy, while MRCP failed to detect malignancy in 3/7 cases. In conclusion, this preliminary experience suggests that 18FDG-PET may prove useful for malignancy detection in IPMN, improving differential diagnosis with benign intraductal papillary growth by functional data.
authors.affiliation: Department of Medical and Surgical Sciences, Surgical Clinic, University of Brescia, Brescia, Italy. baioksurg@hotmail.com
authors.forename: Gian Luca
authors.initials: GL
authors.lastname: Baiocchi
authors.forename: Nazario
authors.initials: N
authors.lastname: Portolani
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertagna
authors.forename: Federico
authors.initials: F
authors.lastname: Gheza
authors.forename: Claudio
authors.initials: C
authors.lastname: Pizzocaro
authors.forename: Raffaele
authors.initials: R
authors.lastname: Giubbini
authors.forename: Stefano M
authors.initials: SM
authors.lastname: Giulini
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000378:metabolism
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18