title: Evaluation of osteoporotic bone structure through synchrotron radiation X-ray microfluorescence images.
abstract: The abnormal accumulation or deficiency of trace elements may theoretically impair the formation of bone and contribute to osteoporosis. In this context, the knowledge of major and trace elements is very important in order to clarify many issues regarding diseases of the bone, such as osteoporosis, that remain unresolved. Several kinds of imaging techniques can be useful to access morphology and the minerals present in osteoporotic bones. In this work, synchrotron radiation X-ray microfluorescence was used as an X-ray imaging technique to investigate bone structures. Therefore, this research aims to improve the knowledge about some aspects of bone quality. The measurements were carried out at the Brazilian Synchrotron Laboratory Light Laboratory, in Brazil. A white beam with an energy range of 4-23 keV, a 45 degrees /45 degrees geometry and a capillary optics were used. It was demonstrated that bone quality can and must be evaluated not only by considering the architecture of bones but also by taking into account the concentration and the distribution of minerals. Our results showed that the elemental distributions in bone zones on a micron scale were very helpful to understand functions in those structures.
authors.affiliation: Nuclear Engineering Program/COPPE/UFRJ, P.O. Box 68509, Av. Horácio Macedo 2030, Sala I-133, Cidade Universitária, 21941-914 Rio de Janeiro, RJ, Brazil. inaya@lin.ufrj.br
authors.forename: I
authors.initials: I
authors.lastname: Lima
authors.forename: M J
authors.initials: MJ
authors.lastname: Anjos
authors.forename: M L F
authors.initials: ML
authors.lastname: Farias
authors.forename: T U
authors.initials: TU
authors.lastname: Pantaleão
authors.forename: V M Corrêa
authors.initials: VM
authors.lastname: da Costa
authors.forename: R T
authors.initials: RT
authors.lastname: Lopes
mesh_terms: D000465:Algorithms; D000818:Animals; D005270:Femur Head / Q000000981:diagnostic imaging*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D010024:Osteoporosis / Q000000981:diagnostic imaging*; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D012031:Refractometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013052:Spectrometry, X-Ray Emission / Q000379:methods*; D017356:Synchrotrons; D014056:Tomography, X-Ray / Q000379:methods*