title: Effects of cerebrolysin on moderate cognitive impairments in cerebral vascular insufficiency (a clinical-electrophysiological study).
abstract: The efficacy of treatment with cerebrolysin was studied in 40 patients with cerebral vascular insufficiency. Cerebrolysin (20 daily i.v. infusions of 10 ml in 200 ml of physiological saline) was found to be an effective means of treating this group of patients. Courses of cerebrolysin treatment decreased the severity of memory and attention impairments, improving the overall cognitive status of the patients. Clinical observations and neuropsychological testing were supported by electrophysiological results, in terms of the P300 cognitive evoked potential. The effects of treatment at the doses used here were delayed and were seen three months after completion of treatment.
authors.affiliation: Department of Nervous Diseases, I. M. Sechenov Moscow Medical Academy, Moscow, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Damulin
authors.forename: N N
authors.initials: NN
authors.lastname: Koberskaya
authors.forename: E A
authors.initials: EA
authors.lastname: Mkhitaryan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000596:Amino Acids / Q000627:therapeutic use*; D001288:Attention / Q000187:drug effects; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000150:complications / Q000188:drug therapy*; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control*; D003210:Concept Formation / Q000187:drug effects; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009496:Neurotensin / Q000502:physiology; D018697:Nootropic Agents / Q000627:therapeutic use*; D011340:Problem Solving / Q000187:drug effects; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
chemical_list: D000596:Amino Acids; D018697:Nootropic Agents; C006952:cerebrolysin; D009496:Neurotensin