Newly developed multiple myeloma in a patient with primary T-cell lymphoma of bone.
Primary non-Hodgkin's lymphoma of bone (PLB) is rare, and generally presents as a single extensive and destructive bone lesion. Histopathologically, most cases present as diffuse large B-cell lymphoma, and T-cell lymphoma is rare. By contrast, multiple myeloma is a disease defined as the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin. We report a case of multiple myeloma that developed during treatment of PLB in a type of T-cell. A 48-yr-old man was diagnosed as T-cell PLB, stage IE, 18 months ago. The patient received the chemoradiotherapy and salvage chemotherapy for PLB. However, the lymphoma progressed with generalized bone pain, and laboratory findings showed bicytopenia and acute renal failure. On bone marrow biopsy, the patient was diagnosed as having multiple myeloma newly developed with primary T-cell lymphoma of bone. In spite of chemotherapy, the patient died of renal failure.
Hwang
Jun-Eul
JE
Department of Internal Medicine, Division of Hemato-Oncology, Chonnam National University Medical School, Gwangju, Korea.
Cho
Sang-Hee
SH
Kim
Ok-Ki
OK
Shim
Hyun-Jeong
HJ
Lee
Se-Ryeon
SR
Ahn
Jae-Sook
JS
Yang
Duk-Hwan
DH
Kim
Yeo-Kyeoung
YK
Lee
Je-Jung
JJ
Kim
Hyeoung-Joon
HJ
Chung
Ik-Joo
IJ
D058186:Acute Kidney Injury / Q000209:etiology; D001859:Bone Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D017809:Fatal Outcome; D006801:Humans; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy