Oral administration of highly oligomeric procyanidins of Jatoba reduces the severity of collagen-induced arthritis.
We have previously reported that highly oligomeric procyanidins (HOPC) purified from Jatoba, a South American herb, ameliorated experimental autoimmune encephalomyelitis (EAE) in mice. In this present study, we report that symptoms of arthritis were also significantly reduced by administering the Jatoba extract, when compared with the vehicle-alone-treated control. Interferon-gamma (IFN-gamma) production by the splenocytes from mice injected with procyanidins was also dramatically decreased. The oral administration of purified HOPC was significantly more effective in disease prevention than the ethanol (EtOH) extract of Jatoba. Green tea polyphenol administration, however, surprisingly facilitated disease development. Observation of the joint histopathology on whole paws derived from the HOPC-treated mice showed complete abrogation of collagen induced arthritis (CIA), a characteristic of chronic inflammation in the synovial tissue. These results demonstrate that HOPC administration had an inhibitory effect on both chronic arthritis and EAE and that the oral administration of HOPC exerted its effect after the induction of secondary immunity.
Miyake
Mika
M
Central Laboratories for Frontier Technology, Kirin Holdings Co, Ltd, Yokohama, Japan. m-miyake@kirin.co.jp
Ide
Kazuki
K
Sasaki
Katsunori
K
Matsukura
Yasuko
Y
Shijima
Kumiko
K
Fujiwara
Daisuke
D
D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy*; D005419:Flavonoids / Q000009:adverse effects; D007371:Interferon-gamma / Q000096:biosynthesis / Q000187:drug effects; D051379:Mice; D010636:Phenols / Q000009:adverse effects; D010946:Plants, Medicinal; D059808:Polyphenols; D044945:Proanthocyanidins / Q000494:pharmacology* / Q000627:therapeutic use; D013154:Spleen / Q000166:cytology; D016896:Treatment Outcome
D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D044945:Proanthocyanidins; D007371:Interferon-gamma