Mesp1 at the heart of mesoderm lineage specification.
Stem cell-based cardiac regeneration requires a detailed understanding of the factors that induce cardiac lineage commitment. In this issue of Cell Stem Cell, Lindsley et al. (2008) and Bondue et al. (2008) use embryonic stem cells to identify a key role for Mesp1 in this process.
Wu
Sean M
SM
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA. smwu@partners.org
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology*; D002454:Cell Differentiation; D047108:Embryonic Development; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology; D006321:Heart / Q000196:embryology* / Q000502:physiology; D008648:Mesoderm / Q000502:physiology*; D051379:Mice; D009206:Myocardium / Q000166:cytology; D012038:Regeneration
D051792:Basic Helix-Loop-Helix Proteins; C101538:Mesp1 protein, mouse