Vascular tolerance to nitroglycerin in ascorbate deficiency: results are in favour of an important role of oxidative stress in nitrate tolerance.
Daiber
Andreas
A
Gori
Tommaso
T
D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D001206:Ascorbic Acid Deficiency / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D004361:Drug Tolerance; D006801:Humans; D005996:Nitroglycerin / Q000494:pharmacology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D012107:Research Design; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
D000975:Antioxidants; D017382:Reactive Oxygen Species; D014665:Vasodilator Agents; D000444:Aldehyde Dehydrogenase; D005996:Nitroglycerin; D001205:Ascorbic Acid