title: Control of ovulation-induced hemoperitoneum by oral contraceptives in a patient with congenital hypoprothrombinemia and in another with congenital factor V deficiency.
abstract: Hemoperitoneum is a serious and often life-threatening bleeding manifestation. This is particularly true for women who carry congenital bleeding disorders. We describe here a hemoperitoneum occurring in 1 patient with congenital prothrombin deficiency and another with congenital factor V deficiency. Both patients have been followed by us for many years. The patient with prothrombin deficiency underwent laparoscopy but was treated consecutively with whole blood, plasma transfusions and 1,000 units of prothrombin complex concentrates. Response was good and she was then placed on oral contraceptives (OC) which prevented any recurrence. The patient with factor V deficiency presented several episodes of ovulation-related bleeding which required hospitalization and fresh frozen plasma transfusions. On the fifth occasion, the patient had to undergo surgery, and a left oophorectomy was carried out. After this last episode, she was also placed on OC which were very effective in preventing further recurrences. Both patients tolerated the medications very well which, in addition, were able to control menometrorrhagia with a consequent decrease over time in transfusional needs. OC are the treatment of choice in congenital bleeding disorders to control both the menorrhagia and, more importantly, ovulation-related hemoperitoneum.
authors.affiliation: Department of Medical and Surgical Sciences, Northeastern Italy Association for the Study of Coagulation Disorders, Padua, Italy. antonio.girolami@unipd.it
authors.forename: A
authors.initials: A
authors.lastname: Girolami
authors.forename: A M
authors.initials: AM
authors.lastname: Lombardi
authors.forename: N
authors.initials: N
authors.lastname: Candeo
authors.forename: P
authors.initials: P
authors.lastname: Scarparo
authors.forename: A
authors.initials: A
authors.lastname: Paternoster
mesh_terms: D000328:Adult; D016913:Blood Component Transfusion / Q000379:methods; D003276:Contraceptives, Oral / Q000008:administration & dosage*; D005166:Factor V Deficiency / Q000150:complications* / Q000628:therapy; D005260:Female; D006465:Hemoperitoneum / Q000209:etiology* / Q000517:prevention & control* / Q000628:therapy; D006801:Humans; D007020:Hypoprothrombinemias / Q000150:complications* / Q000628:therapy; D010535:Laparoscopy / Q000379:methods; D008595:Menorrhagia / Q000517:prevention & control; D034445:Ovulation Inhibition / Q000187:drug effects*; D012008:Recurrence
chemical_list: D003276:Contraceptives, Oral