title: Generalization of monod kinetics for analysis of growth data with substrate inhibition.
abstract: The inhibitory effect of butanol on yeast growth has been studied for the strain Candida utilis ATCC 8205 growing aerobically on butanol under batch conditions. A mathematical expression was then proposed to fit the kinetic pattern of butanol inhibition on the specific growth rate: micro = micro mS/Ks + S [1 - S/Sm]n. The maximum allowable butanol concentration above which cells do not grow was predicted to be 9.16g/L. The proposed model appears to accurately represent the experimental data obtained in this study and the literature data developed for a variety of batch culture systems at widely ranging substrate concentrations.
authors.affiliation: Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada.
authors.forename: J H
authors.initials: JH
authors.lastname: Luong