title: [Effects of beta-asarone on expression of FOS and GAD65 in cortex of epileptic rat induced by penicillin].
abstract: OBJECTIVE
  To study effects of beta-asarone on expression of FOS and GAD65 in cortex of epileptic rat induced by penicillin.
  
  
  METHODS
  The epileptic animal models were induced by penicillin. The rats were randomly divided into beta-asarone of high (100 mg/kg), medium (50 mg/kg), low (25 mg/kg) dose group, positive control group (Phenytoin sodium), negative control group (matrix). The medicine was administered orally. The effects of beta-asarone on expression of FOS and GAD65 in cortex of epileptic rat were detected by immuohistochemistry method.
  
  
  RESULTS
  beta-asarone could raise expression of FOS and reduce expression of GAD65 obviously. There were significant differences between negative control group and beta-asarone group. And it showed significant dose-effect relationship.
  
  
  CONCLUSIONS
  Up-regulation of FOS may be a effective link of anti-epileptic effect of beta-asarone; reduced expression of GAD65 may be a follow-up impact of beta-asarone treatment.
authors.affiliation: The First Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510405, China.
authors.forename: Si-ying
authors.initials: SY
authors.lastname: Fu
authors.forename: Ruo-ming
authors.initials: RM
authors.lastname: Fang
authors.forename: Geng-li
authors.initials: GL
authors.lastname: Fang
authors.forename: Yu-hui
authors.initials: YH
authors.lastname: Xie
authors.forename: Yong-qi
authors.initials: YQ
authors.lastname: Fang
mesh_terms: D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D029064:Araceae / Q000737:chemistry; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D010406:Penicillins; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000927:Anticonvulsants; D004365:Drugs, Chinese Herbal; D010406:Penicillins; D016760:Proto-Oncogene Proteins c-fos; C012195:asarone; D005968:Glutamate Decarboxylase