Sickle cell hepatopathy.
Sickle cell hepatopathy is a well-documented entity that ranges from the self-limiting hepatic right upper quadrant syndrome to the potentially lethal intrahepatic cholestasis and acute hepatic sequestration syndromes. We describe a 26-year-male with homozygous sickle cell disease who had this unique hepatic presentation and was documented to have characteristic findings of cholestasis, portal inflammation and sinusoidal dilatation on histopathology.
Bandyopadhyay
Ranjana
R
Department of Pathology, Medical College, Kolkata 73, India. drsanjay_b@rediffmail.com
Bandyopadhyay
Sanjay K
SK
Dutta
Anita
A
D000006:Abdomen, Acute / Q000209:etiology; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000235:genetics; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D006720:Homozygote; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology; D041781:Jaundice, Obstructive / Q000209:etiology; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D008297:Male