A brief summary of the different types of mass spectrometers used in proteomics.
Recent technical innovations in mass spectrometry-based techniques have resulted in a range of highly sensitive and versatile instruments for high-throughput, high-sensitive, proteome-scale profiling. This wide diversity of instrumentation commercially available for mass spectrometry-based proteomics makes the choice of instrumentation sometimes difficult. The choice of instruments depends on the biological problem and the proteomic strategy chosen for protein identification. This chapter will give a short overview of the instruments routinely used in proteomic laboratories and the technical criteria that should be considered before instrument selection.
Schaeffer-Reiss
Christine
C
Laboratoire de Spectrométrie de Masse Bio-Organique, Institut Pluridisciplinaire Hubert Curien, UMR 7178 CNRS/ Université Louis Pasteur, Strasbourg, France.
D030562:Databases, Protein; D013058:Mass Spectrometry / Q000295:instrumentation*; D010449:Peptide Mapping / Q000295:instrumentation / Q000379:methods; D010455:Peptides / Q000032:analysis; D040901:Proteomics / Q000295:instrumentation* / Q000379:methods; D012680:Sensitivity and Specificity
D010455:Peptides