Vancomycin heteroresistance in bloodstream isolates of Staphylococcus capitis.
Nine Staphylococcus capitis isolates from blood cultures of newborns were examined for resistance to vancomycin. MICs were within the susceptible range, but population profiling revealed a resistant subpopulation. Only isolates with the largest subpopulation were identified as heteroresistant to vancomycin by Etest. This finding may have therapeutic implications.
D'mello
Danaë
D
School of Applied Sciences, RMIT University, Plenty Road, Bundoora, Victoria, Australia.
Daley
Andrew J
AJ
Rahman
Muhammad Shihab
MS
Qu
Yue
Y
Garland
Suzanne
S
Pearce
Christopher
C
Deighton
Margaret A
MA
D006801:Humans; D007231:Infant, Newborn; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013210:Staphylococcus / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology / Q000627:therapeutic use; D020713:Vancomycin Resistance
D014640:Vancomycin