title: Osteoporosis detection using intraoral densitometry.
abstract: OBJECTIVE
  To determine the diagnostic accuracy of mandibular and maxillary bone density in detecting osteoporosis using receiver operating characteristic (ROC) analysis.
  
  
  METHODS
  671 women between 45 years and 70 years of age underwent dual energy X-ray absorptiometry (DXA) of the hip and lumbar spine. This was the gold standard for diagnosing osteoporosis. Intraoral radiography of the upper and lower right premolar region was performed, using an aluminium wedge as a densitometric reference. Jaw bone density was determined using dedicated software. Observer differences and ROC curves were analysed.
  
  
  RESULTS
  For detecting osteoporosis using jaw bone density, the area under the ROC curve (A(z)) was 0.705. For separate analysis of mandibular and maxillary films, sensitivity varied from 33.9% to 38.7% and specificity from 83.5% to 85.3% when using a threshold of 4.3 mm Al equivalent.
  
  
  CONCLUSIONS
  Density of the premolar region reaches a fair diagnostic accuracy, which might improve when including additional factors in the analysis and refining the densitometric tool.
authors.affiliation: Oral Imaging Center, Department of Dentistry, Faculty of Medicine, KU Leuven, Belgium.
authors.forename: O
authors.initials: O
authors.lastname: Nackaerts
authors.forename: R
authors.initials: R
authors.lastname: Jacobs
authors.forename: H
authors.initials: H
authors.lastname: Devlin
authors.forename: S
authors.initials: S
authors.lastname: Pavitt
authors.forename: E
authors.initials: E
authors.lastname: Bleyen
authors.forename: B
authors.initials: B
authors.lastname: Yan
authors.forename: H
authors.initials: H
authors.lastname: Borghs
authors.forename: C
authors.initials: C
authors.lastname: Lindh
authors.forename: K
authors.initials: K
authors.lastname: Karayianni
authors.forename: P
authors.initials: P
authors.lastname: van der Stelt
authors.forename: E
authors.initials: E
authors.lastname: Marjanovic
authors.forename: J E
authors.initials: JE
authors.lastname: Adams
authors.forename: K
authors.initials: K
authors.lastname: Horner
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods*; D000368:Aged; D001641:Bicuspid / Q000000981:diagnostic imaging; D015519:Bone Density / Q000502:physiology; D005260:Female; D006621:Hip Joint / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008334:Mandible / Q000000981:diagnostic imaging*; D008437:Maxilla / Q000000981:diagnostic imaging*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000000981:diagnostic imaging*; D012372:ROC Curve; D016300:Radiography, Bitewing; D012680:Sensitivity and Specificity; D012984:Software