title: Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development.
abstract: A functional calcineurin A fusion to enhanced green fluorescent protein (EGFP), CnaA-EGFP, was expressed in the Aspergillus fumigatus DeltacnaA mutant. CnaA-EGFP localized in actively growing hyphal tips, at the septa, and at junctions between the vesicle and phialides in an actin-dependent manner. This is the first study to implicate calcineurin in septum formation and conidiophore development of a filamentous fungus.
authors.affiliation: Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Praveen Rao
authors.initials: PR
authors.lastname: Juvvadi
authors.forename: Jarrod R
authors.initials: JR
authors.lastname: Fortwendel
authors.forename: Nadthanan
authors.initials: N
authors.lastname: Pinchai
authors.forename: B Zachary
authors.initials: BZ
authors.lastname: Perfect
authors.forename: Joseph
authors.initials: J
authors.lastname: Heitman
authors.forename: William J
authors.initials: WJ
authors.lastname: Steinbach
mesh_terms: D001232:Aspergillus fumigatus / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development*; D019703:Calcineurin / Q000235:genetics / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D025301:Hyphae / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D021381:Protein Transport; D013172:Spores, Fungal / Q000201:enzymology / Q000235:genetics / Q000254:growth & development*
chemical_list: D005656:Fungal Proteins; D019703:Calcineurin