Casares' map function: no need for a 'corrected' Haldane's map function.
A genetic map function M(d) = RF provides a mapping from the additive genetic distance d to the non-additive recombination fraction RF between a given pair of loci, where the recombination fraction is the proportion of gametes that are recombinant between the two loci. Genetic map functions are needed because in most experiments all we can directly observe are the recombination events. However, since a recombination event is only observed if there are an odd number of crossovers between the two loci, recombination fractions are not additive. One of the most widely used map functions is Haldane's map function, which is derived under the assumptions of no chiasma and no chromatid interference, and has been in widespread use since 1919. However, Casares recently proposed a 'corrected' Haldane's map function - we show here that this 'corrected' map function is not correct due to faulty assumptions and mistakes in its derivation.
Weeks
Daniel E
DE
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Crabtree Hall, Room A303, 130 DeSoto Street, Pittsburgh, PA 15261, USA. weeks@pitt.edu
Tang
Xinyu
X
Kwon
Amy M
AM
D002874:Chromosome Mapping; D008957:Models, Genetic; D011995:Recombination, Genetic / Q000235:genetics