title: Adult T-cell leukemia/lymphoma in an adolescent presenting with skin lesions.
abstract: Adult T-cell leukemia/lymphoma is a T-cell malignancy caused by the human T-cell lymphotropic virus-I. Adult T-cell leukemia/lymphoma is primarily a disease of adults due to the long latency period between initial infection and development of leukemia. We present a case of acute adult T-cell leukemia/lymphoma in an adolescent. Skin lesions had appeared 3 years earlier and were the initial sign of human T-cell lymphotropic virus-I infection and T-cell malignancy. Her disease failed to respond to both intensive chemotherapy and antiviral therapy. Cutaneous lesions are sometimes the initial sign of adult T-cell leukemia/lymphoma and early recognition is imperative.
authors.affiliation: Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors.forename: Catherine T
authors.initials: CT
authors.lastname: Lucas
authors.forename: Kendra J
authors.initials: KJ
authors.lastname: Gillis
authors.forename: Jayne M
authors.initials: JM
authors.lastname: Ness
authors.forename: Yuki A
authors.initials: YA
authors.lastname: Hammers
authors.forename: David F
authors.initials: DF
authors.lastname: Crawford
authors.forename: David R
authors.initials: DR
authors.lastname: Kelly
authors.forename: Amy
authors.initials: A
authors.lastname: Theos
mesh_terms: D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis; D015480:Deltaretrovirus Antibodies / Q000032:analysis; D018562:Disease Transmission, Infectious; D017809:Fatal Outcome; D005260:Female; D015490:HTLV-I Infections / Q000635:transmission*; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis* / Q000821:virology; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis* / Q000821:virology; D012867:Skin / Q000473:pathology / Q000821:virology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000821:virology; D065227:Transfusion Reaction
chemical_list: D015703:Antigens, CD; D015480:Deltaretrovirus Antibodies