Beneficial effect of chungkukjang on regulating blood glucose and pancreatic beta-cell functions in C75BL/KsJ-db/db mice.
The current study investigated the antidiabetic effect of chungkukjang, a widely used traditional Korean soybean fermentation food, in a type 2 diabetic animal model, C57BL/KsJ-db/db mice. After a 2-week acclimation period, the db/db mice (male, 5 weeks old) were divided into three groups: diabetic control (AIN-76 diet), chungkukjang (5 g/100 g of diet), and rosiglitazone (0.005 g/100 g of diet). The supplementation of chungkukjang induced a significant reduction of blood glucose and glycosylated hemoglobin level, and it improved insulin tolerance compared to the diabetic control group. Plasma and pancreatic insulin levels of the chungkukjang-supplemented group were significantly higher than those of the diabetic control mice, and the plasma glucagon level was also significantly different. The supplementation of chungkukjang and rosiglitazone significantly elevated hepatic glucokinase activity with a simultaneous reduction of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activity in the db/db mice compared to the diabetic control mice. In addition, the chungkukjang-supplemented group had an increased hepatic glycogen content compared to the diabetic control and rosiglitazone-supplemented groups. Consequently, these results suggest that chungkukjang may be beneficial in improving insulin resistance and hyperglycemia in type 2 diabetic animals that are partly medicated by the regulation of hepatic glucose enzymes and insulin sensitivity in peripheral tissues.
Kim
Dong-Ju
DJ
Department of Food Science and Nutrition, Kyungpook National University, Republic of Korea.
Jeong
Yong-Jin
YJ
Kwon
Joong-Ho
JH
Moon
Kwang-Deog
KD
Kim
Hye-Jin
HJ
Jeon
Seon-Min
SM
Lee
Mi-Kyung
MK
Park
Yong Bok
YB
Choi
Myung-Sook
MS
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology*; D005285:Fermentation; D005934:Glucagon / Q000032:analysis / Q000097:blood; D005941:Glucokinase / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000032:analysis; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000032:analysis / Q000097:blood; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000502:physiology*; D007529:Isoflavones / Q000008:administration & dosage*; D020738:Leptin / Q000097:blood; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010179:Pancreas / Q000737:chemistry; D000077154:Rosiglitazone; D030262:Soybean Proteins / Q000008:administration & dosage*; D013025:Glycine max / Q000737:chemistry; D045162:Thiazolidinediones / Q000008:administration & dosage
D001786:Blood Glucose; D005934:Glucagon; D005941:Glucokinase; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D007529:Isoflavones; D020738:Leptin; D000077154:Rosiglitazone; D030262:Soybean Proteins; D045162:Thiazolidinediones; C525760:chungkookjang