Effects of orally administered bovine lactoperoxidase on dextran sulfate sodium-induced colitis in mice.
The effect of lactoperoxidase (LPO) on dextran sulfate sodium-induced colitis was examined in mice. After 9 d of colitis induction, weight loss, colon shortening, and the histological score were significantly suppressed in mice orally administered LPO (62.5 mg/body/d) as compared to a group administered bovine serum albumin. These results suggest that LPO exhibits anti-inflammatory effects in the gastrointestinal tract.
Shin
Kouichirou
K
Food Science & Technology Institute, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa, Japan. k shin@morinagamilk.co.jp
Horigome
Ayako
A
Yamauchi
Koji
K
Takase
Mitsunori
M
Yaeshima
Tomoko
T
Iwatsuki
Keiji
K
D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents; D002417:Cattle; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D016264:Dextran Sulfate; D007784:Lactoperoxidase / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D016264:Dextran Sulfate; D007784:Lactoperoxidase