Synthesis and antitumor activity of cyclodepsipeptide zygosporamide and its analogues.
The synthesis and structure-activity relationships of zygosporamide, a known potent and selective cytotoxic natural product against SF-268 and RXF 393 cell lines, are described. The potencies of the synthetic zygosporamide are similar to those reported for the natural product toward all cancer cell lines examined with the exception of SF-268, the underlying cause of which remains to be elucidated.
Wang
You
Y
Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China.
Zhang
Feiran
F
Zhang
Yihua
Y
Liu
Jun O
JO
Ma
Dawei
D
D000409:Alanine / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D001688:Biological Products; D047630:Depsipeptides; C530680:zygosporamide; D000409:Alanine