title: Sensing of human plasma fibrinogen on polished, chemically etched and carbon treated titanium surfaces by diffractive optical element based sensor.
abstract: Adsorption of human plasma fibrinogen (HPF) on 6 differently treated titanium samples (polished, polished and etched, and 4 titanium carbide coatings samples produced by using plasma-enhanced chemical vapour deposition (PECVD) method) is investigated by using diffractive optical element (DOE) sensor. Permittivity (susceptibility) change and fluctuation in optical roughness (R(opt)) of treated titanium surface in the presence of background electrolyte without and with HPF molecules are sensed by using DOE sensor and optical ellipsometry. Correlation between transmitted light and thickness of molecule layer was found. The findings allow to sense temporal organization and severity of adsorption of nano-scale HPF molecules on polished, on polished and etched, and on titanium carbide surface.
authors.affiliation: University of Joensuu, Department of Physics and Mathematics, P.O. Box 111, FI-80101Joensuu, Finland. raimo.silvennoinen@joensuu.fi
authors.forename: Raimo
authors.initials: R
authors.lastname: Silvennoinen
authors.forename: Vladimir
authors.initials: V
authors.lastname: Vetterl
authors.forename: Stanislav
authors.initials: S
authors.lastname: Hason
authors.forename: Heikki
authors.initials: H
authors.lastname: Tuononen
authors.forename: Martti
authors.initials: M
authors.lastname: Silvennoinen
authors.forename: Kari
authors.initials: K
authors.lastname: Myller
authors.forename: Ladislav
authors.initials: L
authors.lastname: Cvrcek
authors.forename: Jiri
authors.initials: J
authors.lastname: Vanek
authors.forename: Patrik
authors.initials: P
authors.lastname: Prachar
mesh_terms: D000327:Adsorption; D004573:Electrolytes; D004867:Equipment Design; D005340:Fibrinogen / Q000032:analysis* / Q000737:chemistry*; D006801:Humans; D008956:Models, Chemical; D015233:Models, Statistical; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods; D055095:Optics and Photonics; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*
chemical_list: D004573:Electrolytes; C096521:titanium carbide; D005340:Fibrinogen; D014025:Titanium