title: The influence of laryngopharyngeal reflux in the healing of laryngeal trauma.
abstract: The aim of this clinical study was to evaluate the effect of laryngopharyngeal reflux (LPR) on the healing process of surgical laryngeal trauma. A total of 112 consecutive patients, who suffered from LPR and were scheduled for operation of Reinke edema or laryngeal polyps/nodules (40 and 72 patients, respectively) during a period of 5 years, were included. Diagnosis of LPR was made on the basis of both history and dual pH probe recording during 24 h in the inferior esophagus and the hypopharynx. The reflux finding score (RFS) and the reflux symptom index (RSI) were used to estimate the clinical severity of LPR. In patients with LPR, proton pump inhibitors (PPI) were initiated in half of them, randomly chosen. Fifty LPR-free subjects operated for Reinke edema or laryngeal polyps during the same time period (19 and 31 patients, respectively) were used as controls. In six patients who had been administered PPI, resolution of the disease was observed and no surgical treatment was undertaken. The remaining patients were operated on under general anesthesia by a single surgeon. All patients had 1-year postoperative follow-up. Epithelization was complete in all vocal cords of both the control group and the group of patients who had been administered PPI. Within the group of patients who had not taken PPI, six patients presented granulation tissue or recurrence of the polyps and in two of them revision surgery was needed. RFS and RSI scores showed significant improvement postoperatively, across all the three groups of patients, with major differences observed in the group treated by PPI. Comparison of the postoperative RFS and RSI scores between the two groups of patients with LPR showed statistically significant differences in both, indicating better treatment outcome in those patients who had received PPI. It may be thus concluded that LPR influences epithelization and recurrence of laryngeal polyps or Reinke edema in vocal cords, after partial or total decortication. Surgical outcome is superior in patients with LPR with preoperative and postoperative anti-reflux treatment.
authors.affiliation: ENT Department, G.Genimmatas General hospital, Thessaloniki, Greece.
authors.forename: Ilias
authors.initials: I
authors.lastname: Kantas
authors.forename: Dimitrios G
authors.initials: DG
authors.lastname: Balatsouras
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kamargianis
authors.forename: Michael
authors.initials: M
authors.lastname: Katotomichelakis
authors.forename: Maria
authors.initials: M
authors.lastname: Riga
authors.forename: Vasilis
authors.initials: V
authors.lastname: Danielidis
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007013:Hypopharynx / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D007818:Laryngeal Diseases / Q000150:complications / Q000473:pathology / Q000601:surgery; D007819:Laryngeal Edema / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D007828:Laryngoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000150:complications / Q000473:pathology / Q000601:surgery*; D011182:Postoperative Care; D011183:Postoperative Complications / Q000503:physiopathology / Q000517:prevention & control; D011300:Preoperative Care / Q000379:methods; D011336:Probability; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D012016:Reference Values; D018570:Risk Assessment; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D014827:Vocal Cords / Q000187:drug effects / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D054328:Proton Pump Inhibitors