title: [Effect of antibiotic-impregnated catheters on the incidence of infection after cerebrospinal fluid shunting].
abstract: OBJECTIVE
  Infection is a major complication after cerebrospinal fluid (CSF) shunt systems insertion. Antibiotic-impregnated (AI) catheters seem to reduce infection rate in clinical practice. The objective of this study was to determine if the use of AI catheters reduces Staphylococcus spp. infection rate, as it is the most commonly isolated organism.
  
  
  METHODS
  Authors retrospectively reviewed all patients who underwent rifampin-impregnated and clindamycin-impregnated catheters at our hospital. These included external ventricular catheters (inserted from January 2006 to January 2007) and internalized shunts (inserted from January 2004 to January 2007). They also reviewed patients who underwent insertion of non-impregnated external catheters and internalized shunts during the same periods. Overall infection rate, Staphylococcus spp. infection rate and gram negative bacilli infection rate were compared in both groups by means of chi2 test.
  
  
  RESULTS
  Sixty-five procedures with AI catheters and 66 procedures with non-AI catheters were performed. Overall infection rate as well as Staphylococcus spp. infection rate were significantly lower in the AI catheters cohort (p = 0.046 and p = 0.029, respectively), without increasing gram negative bacilli infections.
  
  
  CONCLUSIONS
  The use of rifampin and clindamycin-impregnated catheters is a useful tool to reduce Staphylococcus spp. infections after CSF shunting procedures. However, future clinical trials are required to confirm these results.
authors.affiliation: Servicio de Neurocirugía, Hospital Clínico San Carlos, Madrid, España. rgutierrezgonzalez@yahoo.es
authors.forename: Raquel
authors.initials: R
authors.lastname: Gutiérrez-González
authors.forename: Gregorio R
authors.initials: GR
authors.lastname: Boto
authors.forename: Nieves
authors.initials: N
authors.lastname: González
authors.forename: Isabel
authors.initials: I
authors.lastname: Viudez
authors.forename: Alvaro
authors.initials: A
authors.lastname: Pérez-Zamarrón
authors.forename: Mónica
authors.initials: M
authors.lastname: Rivero-Garvía
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D055499:Catheter-Related Infections / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents