Plasmodium development in the mosquito: biology bottlenecks and opportunities for mathematical modeling.
Quantitative analyses of malaria parasite development are necessary to assess the efficacy of control measures. Such analyses in the mammalian host have been difficult to implement, lagging behind the use of antiparasitic drugs, vaccine development and transmission-blocking strategies. Even less is known about the genetic, environmental and other factors that impact sporogony in the mosquito host. Here, we summarize current knowledge and review a first attempt to model sporogonic development quantitatively.
Drexler
Anna L
AL
Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, CA 95616, USA.
Vodovotz
Yoram
Y
Luckhart
Shirley
S
D000818:Animals; D005075:Biological Evolution; D009033:Culicidae / Q000469:parasitology*; D007303:Insect Vectors / Q000469:parasitology*; D016778:Malaria, Falciparum / Q000517:prevention & control / Q000635:transmission; D008954:Models, Biological; D010963:Plasmodium falciparum / Q000502:physiology*