title: Pregnancy outcome of women who developed proteinuria in the absence of hypertension after mid-gestation.
abstract: OBJECTIVE
  To characterize the clinical features of women with singleton pregnancies who develop proteinuria in the absence of hypertension after mid-gestation.
  
  
  METHODS
  Seventy-nine women who developed proteinuria and/or hypertension at and after 20 weeks of gestation were reviewed, focusing on the gestational week at which significant proteinuria (>0.3 g/day) and/or hypertension developed.
  
  
  RESULTS
  Thirty-seven (47%) women exhibited new-onset proteinuria (>0.3 g/day) in the absence of hypertension, 33 (42%) exhibited new-onset hypertension in the absence of proteinuria, and 9 (11%) exhibited both proteinuria and hypertension. Nineteen (51%) of 37 women who exhibited new proteinuria in the absence of hypertension and 5 (15%) of 33 women who exhibited new hypertension in the absence of proteinuria progressed to preeclampsia (P=0.002). Among women who exhibited new proteinuria, 10 (77%) out of 13 women and 9 (38%) out of 24 women who developed proteinuria at <32 weeks and >or=32 weeks, respectively, progressed to preeclampsia (P=0.022).
  
  
  CONCLUSIONS
  Women with new-onset proteinuria in the absence of hypertension may be more likely to progress to preeclampsia than women with a presumptive diagnosis of gestational hypertension, and the likelihood of progression may be significantly greater among women with earlier presentation.
authors.affiliation: Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo, Japan. mmamoru@med.hokudai.ac.jp
authors.forename: Mamoru
authors.initials: M
authors.lastname: Morikawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamada
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamada
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Cho
authors.forename: Hideto
authors.initials: H
authors.lastname: Yamada
authors.forename: Noriaki
authors.initials: N
authors.lastname: Sakuragi
authors.forename: Hisanori
authors.initials: H
authors.lastname: Minakami
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000175:diagnosis*; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011507:Proteinuria / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D012189:Retrospective Studies; D055815:Young Adult