title: The association of advanced glycation end-products with glutathione status.
abstract: BACKGROUND
  The aim of this study was to investigate oxidative stress with regard to the concentrations of advanced oxidation protein products (AOPP), advanced glycation end-products (AGEs), pentosidine, glycated albumin, reduced glutathione (GSH) and oxidized glutathione (GSSG), glutathione redox ratios and thiobarbituric acid-reactive substances (TBARS) in non-diabetic patients undergoing continuous ambulatory peritoneal dialysis (CAPD).
  
  
  METHODS
  The study group consisted of 52 non-diabetic CAPD patients and 34 healthy controls. AOPP, AGEs, pentosidine and glycated albumin were measured in plasma, whereas GSH, GSSG and TBARS concentrations were measured in erythrocytes of both patients and controls.
  
  
  RESULTS
  All parameters were found to be significantly increased, except the glutathione redox ratio, which was found to be decreased in patients undergoing CAPD. Multiple regression analysis showed that AGEs were the only independent predictor of glutathione redox ratio, whereas AGEs, glycated albumin and TBARS were each found to be independent predictors of albumin concentration.
  
  
  CONCLUSIONS
  Our results support the hypothesis that oxidative stress and AOPPs/AGEs constitute important risk factors in CAPD patients. The negative relationship between albumin and both AGEs and TBARS suggests that the decrease in albumin may contribute to the increased advanced glycation and lipid peroxidation. The negative relationship between glutathione redox ratio and AGEs suggests that late products of glycation play an important role in the development of oxidative stress observed in patients undergoing peritoneal dialysis treatment.
authors.affiliation: Faculty of Medicine, Department of Biochemistry, Akdeniz University, Antalya, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Sahin
authors.forename: Ayse Yesim
authors.initials: AY
authors.lastname: Göçmen
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Koçak
authors.forename: Murat
authors.initials: M
authors.lastname: Tuncer
authors.forename: Saadet
authors.initials: S
authors.lastname: Gümüslü
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000097:blood* / Q000378:metabolism*; D017127:Glycation End Products, Advanced / Q000097:blood*; D006031:Glycosylation; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010531:Peritoneal Dialysis, Continuous Ambulatory
chemical_list: D017127:Glycation End Products, Advanced; D005978:Glutathione