Enhanced affinity of ketotifen toward tamarind seed polysaccharide in comparison with hydroxyethylcellulose and hyaluronic acid: a nuclear magnetic resonance investigation.
Nuclear magnetic resonance (NMR) spectroscopy demonstrated that, in aqueous solution, ketotifen fumarate bound more strongly to tamarind seed polysaccharide (TSP) than to hydroxyethylcellulose or hyaluronic acid. Results were confirmed by dynamic dialysis technique.
Uccello-Barretta
Gloria
G
Università di Pisa, Dipartimento di Chimica e Chimica Industriale, Via Risorgimento 35, I-56126 Pisa, Italy. gub@dcci.unipi.it
Nazzi
Samuele
S
Balzano
Federica
F
Di Colo
Giacomo
G
Zambito
Ylenia
Y
Zaino
Chiara
C
Sansò
Marco
M
Salvadori
Eleonora
E
Benvenuti
Marco
M
D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D006820:Hyaluronic Acid / Q000737:chemistry*; D007665:Ketotifen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011134:Polysaccharides / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*; D013329:Structure-Activity Relationship; D029861:Tamarindus / Q000737:chemistry*
D011134:Polysaccharides; D002482:Cellulose; D006820:Hyaluronic Acid; C002283:hydroxyethylcellulose; D007665:Ketotifen