title: [Intratympanic dexamethasone for refractory sudden deafness].
abstract: OBJECTIVE
  To observe the clinical efficacy of intratympanic dexamethasone (IT-DEX) for sudden deafness (SD) which were inefficient and contraindicant for systemic steroid.
  
  
  METHODS
  Thirty-four patients who were inefficient and contraindicant for systemic steroid were treated by IT-DEX (5 g/L) for 4 times within 12 days. The improvement of audits, tinnitus and stuffy were observed. And the results between the different influencing factor such as age, sex and course of disease were compared by statistical analysis.
  
  
  RESULTS
  1) For total patients, the effective power of audits, tinnitus and stuffy were 52.9%, 58.8% and 82.4% respectively. And the patients who treated within 2 weeks result in higher effective power of audits and tinnitus than those having been treated for more than 2 weeks, but there was no significant difference between these two groups (P >0.05). 2) For the patients who were inefficient and contraindicant for systemic steroid, the audible effective power of them were 44.4% and 62.5% respectively.
  
  
  CONCLUSIONS
  IT-DEX can treat refractory SD effectively and safely. It is an effective treatment for the patients who were contraindicant for systemic steroid, and it could be used for salvage for the patients who were inefficient for systemic steroid.
authors.affiliation: Department of Otorhinolaryngology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
authors.forename: Daijie
authors.initials: D
authors.lastname: Jia
authors.forename: Zhaobing
authors.initials: Z
authors.lastname: Qin
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Sujuan
authors.initials: S
authors.lastname: Li
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004333:Drug Administration Routes; D005260:Female; D003639:Hearing Loss, Sudden / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014432:Tympanic Membrane; D055815:Young Adult
chemical_list: D003907:Dexamethasone