title: A simple and efficient approach to the synthesis of 4H-furo[3,4-b]pyrans via a three-component reaction of isocyanides.
abstract: A three-component reaction of an isocyanide, a dialkyl acetylenedicarboxylate, and tetronic acid in dichloromethane at room temperature afforded 4H-furo[3,4-b]pyran derivatives. These compounds are closely related with ring systems, TAN-2483B, TAN-2483A, and FD-211 which have a broad spectrum of biological activity.
authors.affiliation: Department of Chemistry, Shahid Beheshti University, PO Box 19396-4716, Tehran 19839-4716, Iran. a-shaabani@cc.sbu.ac.ir
authors.forename: Ahmad
authors.initials: A
authors.lastname: Shaabani
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Soleimani
authors.forename: Afshin
authors.initials: A
authors.lastname: Sarvary
authors.forename: Ali Hossein
authors.initials: AH
authors.lastname: Rezayan
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003486:Cyanides / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015195:Drug Design; D005663:Furans / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D008956:Models, Chemical; D011714:Pyrans / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis
chemical_list: D003486:Cyanides; C092867:FD 211; D005663:Furans; D007783:Lactones; D011714:Pyrans; D011743:Pyrimidines; C475530:TAN-2483A; C490945:fusidilactone B; C490946:massarilactone B; C003422:tetronic acid