title: Fluorescent probes and labels for biomedical applications.
abstract: Fluorescence probes and labels have become indispensable tools for clinical diagnostics, high-throughput screening, and other biomedical applications. We have developed several classes of new squaraine-based red and near-infrared (NIR) probes and labels (SETA and Square series), naphthalimide-based fluorescence lifetime dyes (SeTau series), and cyanine- and squaraine-based quenchers (SQ series). This report discusses the spectral and photophysical properties of these new markers. In particular, the red and NIR dyes of the SETA and Square series are extremely bright, with photostabilities that are unmatched by any other dyes in the same spectral region.
authors.affiliation: State Scientific Institution Institute for Single Crystals of the National Academy of Sciences of Ukraine, 60 Lenin Ave., 61001 Kharkov, Ukraine. patsenker@isc.kharkov.com
authors.forename: Leonid
authors.initials: L
authors.lastname: Patsenker
authors.forename: Anatoliy
authors.initials: A
authors.lastname: Tatarets
authors.forename: Olga
authors.initials: O
authors.lastname: Kolosova
authors.forename: Olena
authors.initials: O
authors.lastname: Obukhova
authors.forename: Yevgeniy
authors.initials: Y
authors.lastname: Povrozin
authors.forename: Iryna
authors.initials: I
authors.lastname: Fedyunyayeva
authors.forename: Inna
authors.initials: I
authors.lastname: Yermolenko
authors.forename: Ewald
authors.initials: E
authors.lastname: Terpetschnig
mesh_terms: D000818:Animals; D002417:Cattle; D003503:Cyclobutanes / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007074:Immunoglobulin G / Q000737:chemistry; D008027:Light; D008956:Models, Chemical; D010636:Phenols / Q000737:chemistry*; D010777:Photochemistry / Q000379:methods; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D012709:Serum Albumin / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013997:Time Factors
chemical_list: D003503:Cyclobutanes; D005456:Fluorescent Dyes; D007074:Immunoglobulin G; D010636:Phenols; D012709:Serum Albumin; C480596:squaraine