title: Novel interactions of TG2 with heparan sulfate proteoglycans: reflection on physiological implications.
abstract: This mini-review brings together information from publications and recent conference proceedings that have shed light on the biological interaction between transglutaminase-2 and heparan sulphate proteoglycans. We subsequently draw hypotheses of possible implications in the wound healing process. There is a substantial overlap in the action of transglutaminase-2 and the heparan sulphate proteoglycan syndecan-4 in normal and abnormal wound repair. Our latest findings have identified syndecan-4 as a possible binding and signalling partner of fibronectin-bound TG2 and support the idea that transglutaminase-2 and syndecan-4 act in synergy.
authors.affiliation: School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, UK. elisabetta.verderio-edwards@ntu.ac.uk
authors.forename: E A M
authors.initials: EA
authors.lastname: Verderio
authors.forename: A
authors.initials: A
authors.lastname: Scarpellini
authors.forename: T S
authors.initials: TS
authors.lastname: Johnson
mesh_terms: D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism*; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000378:metabolism*
chemical_list: D019812:Heparan Sulfate Proteoglycans; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins