title: Legionnaires' disease with hypoperfusion in the cerebellum and frontal lobe on single photon emission computed tomography.
abstract: A 59-year-old man was admitted for further investigation of headache. Neurological examination revealed memory loss, disorientation, and bilateral intention tremor. Legionella pneumophila antigen was detected in the urine. Brain magnetic resonance diffusion-weighted images showed marked hyperintensity in the splenium of the corpus callosum without other abnormalities. Single photon emission CT with Tc-99m hexamethyl-propyleneamine oxime showed multi-focal hypoperfusion in the brain, involving mainly the cerebellum and frontal lobe. This is the first report demonstrating cerebellar and frontal lobe hypoperfusion without corresponding MRI abnormalities in a patient with central nervous system Legionnaires' disease.
authors.affiliation: Department of Neurology, Shizuoka Red Cross Hospital, Shizuoka, Japan. nboimai@ac.mbn.or.jp
authors.forename: Noboru
authors.initials: N
authors.lastname: Imai
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Yagi
authors.forename: Takashi
authors.initials: T
authors.lastname: Konishi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Serizawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kobari
mesh_terms: D020806:Central Nervous System Bacterial Infections / Q000382:microbiology* / Q000473:pathology; D002526:Cerebellar Diseases / Q000209:etiology* / Q000473:pathology; D003337:Corpus Callosum / Q000473:pathology*; D005625:Frontal Lobe / Q000473:pathology*; D006261:Headache / Q000209:etiology; D006801:Humans; D007877:Legionnaires' Disease / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019690:Technetium Tc 99m Exametazime