title: The natural compound benzoxazolin-2(3H)-one selectively retards cell cycle in lettuce root meristems.
abstract: Benzoxazolin-2(3H)-one (BOA) is a natural plant product that is phytotoxic to target plant species, inhibiting germination and growth and causing oxidative damage. We investigated its effects on the root meristems of seedlings of lettuce (Lactuca sativa) by means of light and transmission electron microscopy, flow cytometry, and conventional determination of mitotic index. Flow cytometry analyses and mitotic index showed a retard of cell cycle in BOA-treated meristems with selective activity at G2/M checkpoint.
authors.affiliation: Department of Plant Biology and Soil Science, University of Vigo, Campus Lagoas-Marcosende s/n, E-36310 Vigo, Spain. adela@uvigo.es
authors.forename: Adela M
authors.initials: AM
authors.lastname: Sánchez-Moreiras
authors.forename: Teodoro Coba
authors.initials: TC
authors.lastname: de la Peña
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Reigosa
mesh_terms: D001583:Benzoxazoles / Q000494:pharmacology*; D001688:Biological Products / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D006918:Hydroxyurea / Q000494:pharmacology; D018545:Lactuca / Q000166:cytology* / Q000187:drug effects* / Q000254:growth & development; D046529:Microscopy, Electron, Transmission; D018517:Plant Roots / Q000166:cytology / Q000187:drug effects; D036226:Seedlings / Q000187:drug effects / Q000254:growth & development
chemical_list: D001583:Benzoxazoles; D001688:Biological Products; C017057:benzoxazolone; D006918:Hydroxyurea