title: Cancer-associated antigens and antigen arrays in serological diagnostics of malignant tumors.
abstract: The appearance of antibodies to cancer-associated antigens in biological fluids (particularly, in blood sera) of cancer patients is now a well-established fact, and their detection by immunochemical methods is a promising approach to diagnostics of malignant neoplasms. In this review, we consider some immunobiological aspects of the most extensively studied cancer-associated B-cell antigens, various applications of autoantibodies as cancer biomarkers, and prospects for the use of antigen arrays for improving diagnostic sensitivity.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia. belous_p@rambler.ru
authors.forename: P V
authors.initials: PV
authors.lastname: Belousov
authors.forename: D V
authors.initials: DV
authors.lastname: Kuprash
authors.forename: A Yu
authors.initials: AY
authors.lastname: Sazykin
authors.forename: S V
authors.initials: SV
authors.lastname: Khlgatian
authors.forename: D N
authors.initials: DN
authors.lastname: Penkov
authors.forename: Yu V
authors.initials: YV
authors.lastname: Shebzukhov
authors.forename: S A
authors.initials: SA
authors.lastname: Nedospasov
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000097:blood* / Q000235:genetics / Q000276:immunology; D001324:Autoantigens / Q000097:blood / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation; D006801:Humans; D046228:Microarray Analysis; D009369:Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D012698:Serologic Tests
chemical_list: D000951:Antigens, Neoplasm; D001324:Autoantigens