[Comparative genomic hybridization analysis of nonsyndromic cleft lip with palate].
OBJECTIVE
To identify the genetic alterations in nonsyndromic cleft lip and palate (NSCLP).


METHODS
Comparative genomic hybridization was applied to investigate the genomic imbalance (the gain or loss of genetic material) in 7 cases of NSCLP.


RESULTS
It showed that the loss of chromosome DNA copies happened in chromosome 6, 7, 10, 13, 14, 16, 20, 22 and the gain of chromosome DNA copies happened in chromosome 5, 15, 18, 19. Conclusions 13q had a high frequency (71.4%) of chromosome loss.


CONCLUSIONS
Abnormal chromosome DNA copies happen in all the patients with NSCLP. Most of the patients have chromosome DNA copies loss. It suggests that loss of inhibitory gene may be related to the NSCLP. The related inhibitory gene may locate in 13q.
Zhang
Wen-Guang
WG
Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
Luo
Shao-Jun
SJ
Zhu
Shao-Fang
SF
Tang
Shao-Ming
SM
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002681:China / Q000208:ethnology; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D055028:Comparative Genomic Hybridization; D004247:DNA; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007223:Infant; D009154:Mutation; D010641:Phenotype; D055815:Young Adult
D004247:DNA