title: Omega-3 fatty acids (fish-oil) and depression-related cognition in healthy volunteers.
abstract: Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation may be beneficial in the treatment of several psychiatric disorders, including depression. A small number of studies have suggested that there may also be cognitive and mood effects in healthy samples. The purpose of the present study was to investigate the effects of n-3 PUFA on depression-relevant cognitive functioning in healthy individuals. Fifty-four healthy university students were randomized to receive either n-3 PUFA supplements or placebo for 4 weeks in a double-blind design. The test battery included measures of cognitive reactivity, attention, response inhibition, facial emotion recognition, memory and risky decision-making. Results showed few effects of n-3 PUFAs on cognition and mood states. The n-3 PUFA group made fewer risk-averse decisions than the placebo group. This difference appeared only in non-normative trials of the decision-making test, and was not accompanied by increased impulsiveness. N-3 PUFAs improved scores on the control/perfectionism scale of the cognitive reactivity measure. No effects were found on the other cognitive tasks and no consistent effects on mood were observed. The present findings indicate that n-3 PUFA supplementation may have a selective effect on risky decision making in healthy volunteers, which is unrelated to impulsiveness.
authors.affiliation: Department of Psychology, Leiden University, Leiden, The Netherlands. nantypa@fsw.leidenuniv.nl
authors.forename: N
authors.initials: N
authors.lastname: Antypa
authors.forename: A J W
authors.initials: AJ
authors.lastname: Van der Does
authors.forename: A H M
authors.initials: AH
authors.lastname: Smelt
authors.forename: R D
authors.initials: RD
authors.lastname: Rogers
mesh_terms: D000339:Affect / Q000187:drug effects; D003071:Cognition / Q000187:drug effects*; D003657:Decision Making / Q000187:drug effects; D003863:Depression / Q000178:diet therapy; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D010349:Patient Compliance; D011597:Psychomotor Performance / Q000187:drug effects; D055815:Young Adult
chemical_list: D015525:Fatty Acids, Omega-3