title: Coffee improves auditory neuropathy in diabetic mice.
abstract: Coffee is a widely consumed beverage and has recently received considerable attention for its possible beneficial effects. Auditory neuropathy is a hearing disorder characterized by an abnormal auditory brainstem response. This study examined the auditory neuropathy induced by diabetes and investigated the action of coffee, trigonelline, and caffeine to determine whether they improved diabetic auditory neuropathy in mice. Auditory brainstem responses, auditory middle latency responses, and otoacoustic emissions were evaluated to assess auditory neuropathy. Coffee or trigonelline ameliorated the hearing threshold shift and delayed latency of the auditory evoked potential in diabetic neuropathy. These findings demonstrate that diabetes can produce a mouse model of auditory neuropathy and that coffee consumption potentially facilitates recovery from diabetes-induced auditory neuropathy. Furthermore, the active constituent in coffee may be trigonelline.
authors.affiliation: Department of Audiology, Nambu University, Gwangju, South Korea.
authors.forename: Bin Na
authors.initials: BN
authors.lastname: Hong
authors.forename: Tae Hoo
authors.initials: TH
authors.lastname: Yi
authors.forename: Raekil
authors.initials: R
authors.lastname: Park
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.forename: Tong Ho
authors.initials: TH
authors.lastname: Kang
mesh_terms: D000161:Acoustic Stimulation; D000470:Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001306:Auditory Pathways / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology; D002110:Caffeine / Q000494:pharmacology / Q000627:therapeutic use; D003056:Cochlear Nerve / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D003069:Coffee / Q000737:chemistry*; D003389:Cranial Nerve Diseases / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000503:physiopathology*; D004195:Disease Models, Animal; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects / Q000502:physiology; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology
chemical_list: D000470:Alkaloids; D003069:Coffee; D010726:Phosphodiesterase Inhibitors; D002110:Caffeine; C009560:trigonelline