title: Recurrence after ROLL lumpectomy for invasive breast cancer.
abstract: BACKGROUND
  Impalpable breast lesions are being successfully targeted by means of radio-guided occult lesion localisation (ROLL). Although ROLL allows adequate removal of sub-clinical breast lesions within a smaller volume of glandular tissue no long-term outcomes have been reported.
  
  
  OBJECTIVE
  To evaluate the recurrence of invasive cancer after ROLL lumpectomy.
  
  
  METHODS
  A consecutive series of impalpable invasive breast cancers excised with ROLL (151 pts; Dec 2002-June 2006) has been followed up for local and/or systemic recurrence with six monthly clinical examinations and 18 monthly mammograms. Bone scan, liver and brain imaging were requested when clinically appropriate. Clinical and/or radiological suspicious lesions for local recurrence were confirmed pathologically.
  
  
  RESULTS
  The median follow-up was 33 months with all patients having a minimum 22 months follow-up. Three (out of 151 impalpable invasive cancers) local recurrences occurred (1.98%).
  
  
  CONCLUSIONS
  Local recurrence of sub-clinical invasive breast cancer excised with radioisotope guidance compares well with the existing localisation techniques. Its implementation is highly recommended.
authors.affiliation: Department of Surgery, Whiston Hospital, UK.
authors.forename: H S J
authors.initials: HS
authors.lastname: Ramesh
authors.forename: S
authors.initials: S
authors.lastname: Anguille
authors.forename: L S
authors.initials: LS
authors.lastname: Chagla
authors.forename: O
authors.initials: O
authors.lastname: Harris
authors.forename: S
authors.initials: S
authors.lastname: Desmond
authors.forename: R
authors.initials: R
authors.lastname: Thind
authors.forename: R A
authors.initials: RA
authors.lastname: Audisio
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015412:Mastectomy, Segmental / Q000379:methods* / Q000706:statistics & numerical data; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D016896:Treatment Outcome