title: The Systems Biology Research Tool: evolvable open-source software.
abstract: BACKGROUND
  Research in the field of systems biology requires software for a variety of purposes. Software must be used to store, retrieve, analyze, and sometimes even to collect the data obtained from system-level (often high-throughput) experiments. Software must also be used to implement mathematical models and algorithms required for simulation and theoretical predictions on the system-level.
  
  
  RESULTS
  We introduce a free, easy-to-use, open-source, integrated software platform called the Systems Biology Research Tool (SBRT) to facilitate the computational aspects of systems biology. The SBRT currently performs 35 methods for analyzing stoichiometric networks and 16 methods from fields such as graph theory, geometry, algebra, and combinatorics. New computational techniques can be added to the SBRT via process plug-ins, providing a high degree of evolvability and a unifying framework for software development in systems biology.
  
  
  CONCLUSIONS
  The Systems Biology Research Tool represents a technological advance for systems biology. This software can be used to make sophisticated computational techniques accessible to everyone (including those with no programming ability), to facilitate cooperation among researchers, and to expedite progress in the field of systems biology.
authors.affiliation: Department of Biochemistry, University of Zurich, Zurich, Switzerland. j.wright@bioc.uzh.ch
authors.forename: Jeremiah
authors.initials: J
authors.lastname: Wright
authors.forename: Andreas
authors.initials: A
authors.lastname: Wagner
mesh_terms: D003365:Costs and Cost Analysis; D012984:Software / Q000191:economics; D049490:Systems Biology / Q000379:methods; D014584:User-Computer Interface