title: Obstetric outcomes following vitrification of in vitro and in vivo matured oocytes.
abstract: OBJECTIVE
  To evaluate obstetric outcomes with oocyte vitrification after ovarian stimulation (OS) and in vitro maturation (IVM) of immature oocytes.
  
  
  METHODS
  A prospective trial from October 2003 to April 2007.
  
  
  METHODS
  University-based medical center.
  
  
  METHODS
  OS group: 38 patients undergoing intrauterine insemination who overresponded to OS. IVM group: 20 patients who had previous unsuccessful intrauterine insemination.
  
  
  METHODS
  Mature oocyte retrieval following OS. Immature oocyte retrieval and IVM. Oocyte vitrification, thawing, insemination, and transfer of the resulting embryos.
  
  
  METHODS
  Live-birth rates and obstetric outcomes.
  
  
  RESULTS
  The OS group was superior to the IVM group in terms of oocyte survival (81.4 +/- 22.6% vs. 67.5 +/- 26.1%), fertilization rate (75.6 +/- 22.5% vs. 64.2 +/- 19.9%), and cumulative embryo score (38.4 +/- 22.3 vs. 20.0 +/- 13.8). However, the differences in the implantation rate per embryo (19.1 +/- 25.8% vs. 9.6 +/- 24.1%), clinical pregnancy rate per cycle started (44.7%, vs. 20.0%), and live-birth rate per cycle started (39.5% vs. 20.0%) were not statistically significant. Twenty healthy babies were born in the OS group and four in the IVM group.
  
  
  CONCLUSIONS
  Pregnancies achieved with vitrification of oocytes after OS and IVM treatments do not appear to be associated with adverse pregnancy outcomes. Vitrification of IVM oocytes represents a novel option for fertility preservation.
authors.affiliation: McGill Reproductive Center, McGill University Health Centre, Montreal, Quebec, Canada.
authors.forename: Ri-Cheng
authors.initials: RC
authors.lastname: Chian
authors.forename: Jack Y J
authors.initials: JY
authors.lastname: Huang
authors.forename: Lucy
authors.initials: L
authors.lastname: Gilbert
authors.forename: Weon-Young
authors.initials: WY
authors.lastname: Son
authors.forename: Hananel
authors.initials: H
authors.lastname: Holzer
authors.forename: Shan Jin
authors.initials: SJ
authors.lastname: Cui
authors.forename: William M
authors.initials: WM
authors.lastname: Buckett
authors.forename: Togas
authors.initials: T
authors.lastname: Tulandi
authors.forename: Seang Lin
authors.initials: SL
authors.lastname: Tan
mesh_terms: D002470:Cell Survival; D015925:Cryopreservation / Q000379:methods*; D004624:Embryo Transfer / Q000379:methods; D005260:Female; D005306:Fertilization; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology; D007248:Infertility, Male / Q000453:epidemiology; D008297:Male; D054315:Oocyte Retrieval; D009865:Oocytes / Q000166:cytology / Q000502:physiology*; D009926:Organ Preservation / Q000379:methods; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011446:Prospective Studies