Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis.
OBJECTIVE
To evaluate the efficacy and tolerability of a vaginal pessary containing 750 mg of metronidazole and 200 mg of miconazole nitrate used daily for 7 days in the treatment of vaginitis.


METHODS
Ninety-two women with vaginitis participated in this phase 3 study using one vaginal pessary daily for 7 days. Gynecological and microbiological evaluations were carried out prior to and following treatment.


RESULTS
Reductions occurred in symptoms and signs of vaginitis. Clinical cure rate was 87.7%, while the cure rates according to microscopy and Candida albicans culture were 81.8% and 73.9%, respectively. The cure rate for bacterial vaginosis was 75% and culture of Gardnerella vaginalis turned negative in 63.6% of cases following treatment. The medication was well tolerated.


CONCLUSIONS
Use of a combination of 750 mg of metronidazole and 200 mg of miconazole in a single daily application was found to be effective in the treatment of the most common causes of vaginitis.
Peixoto
Fabio
F
Laboratory of Human Reproduction, Teaching Hospital, Federal University of Minas Gerais, Brazil. fabiocpeixoto@terra.com.br
Camargos
Aroldo
A
Duarte
Geraldo
G
Linhares
Iara
I
Bahamondes
Luis
L
Petracco
Alvaro
A
D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006194:Gardnerella vaginalis / Q000187:drug effects*; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage* / Q000009:adverse effects; D008825:Miconazole / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D010570:Pessaries; D014247:Trichomonas Vaginitis / Q000188:drug therapy*
D000935:Antifungal Agents; D008795:Metronidazole; D008825:Miconazole