Mono- and dicationic short PEG and methylene dioxyalkylglycerols for use in synthetic gene delivery systems.
A range of monocationic and dicationic dioxyalkylglycerol cytofectins have been synthesised possessing methylene and short n-ethylene glycol spacers. The monocationic compounds were found to be effective in transfections when formulated as lipopolyplexes with peptide and DNA components, in particular with shorter PEG head groups which may have less effect on peptide targeting in the ternary complex.
Hurley
Christopher A
CA
Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
Wong
John B
JB
Ho
Jimmy
J
Writer
Michele
M
Irvine
Scott A
SA
Lawrence
M Jayne
MJ
Hart
Stephen L
SL
Tabor
Alethea B
AB
Hailes
Helen C
HC
D000595:Amino Acid Sequence; D002460:Cell Line; D004247:DNA / Q000378:metabolism; D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000378:metabolism; D005990:Glycerol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry / Q000378:metabolism*; D014162:Transfection
D010455:Peptides; D011092:Polyethylene Glycols; D004247:DNA; D005990:Glycerol