title: Idiopathic neuropathy patients are at high risk for metabolic syndrome.
abstract: BACKGROUND
  Idiopathic neuropathy patients are at high risk of impaired glucose tolerance (IGT). Hyperglycemia, low high density lipoprotein (HDL), elevated triglycerides (TRG), hypertension and central obesity co-associate and constitute the metabolic syndrome. Patients with hyperglycemia are at high risk of having the syndrome and each of its features. Our null hypothesis was that patients with neuropathy and IGT would have a higher prevalence of other metabolic syndrome features than those without hyperglycemia. The primary objective was to determine if metabolic syndrome features other than hyperglycemia increase neuropathy risk.
  
  
  METHODS
  The prevalence of metabolic syndrome features was determined among 219 sequential patients with idiopathic peripheral neuropathy. Subjects were classified as having IGT or normoglycemia. The prevalence of metabolic syndrome was compared to published population prevalence data. To compensate for potential referral bias, data were also compared for175 diabetic subjects without neuropathy, given the well-recognized risk of metabolic syndrome among diabetic individuals.
  
  
  RESULTS
  Contrary to our hypothesis, neuropathy patients with normoglycemia and IGT shared a similarly elevated prevalence of metabolic syndrome features compared to published normal populations. Compared to diabetic subjects without neuropathy, the normoglycemic neuropathy patients had significantly higher total and LDL cholesterol, and a higher prevalence of abnormal HDL and triglycerides. The prevalence of obesity and hypertension was similar among patient groups. Normoglycemic neuropathy subjects had significantly more features of metabolic syndrome (other than hyperglycemia) than diabetics.
  
  
  CONCLUSIONS
  These findings demonstrate an association between neuropathy and metabolic syndrome features other than hyperglycemia. Lipid abnormalities are particularly prevalent among neuropathy subjects.
authors.affiliation: Department of Neurology, University of Utah, United States. Gordon.smith@hsc.utah.edu
authors.forename: A Gordon
authors.initials: AG
authors.lastname: Smith
authors.forename: Kristi
authors.initials: K
authors.lastname: Rose
authors.forename: J Robinson
authors.initials: JR
authors.lastname: Singleton
mesh_terms: D000368:Aged; D000596:Amino Acids; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002857:Chromium; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000453:epidemiology* / Q000209:etiology; D008875:Middle Aged; D009539:Nicotinic Acids; D009765:Obesity / Q000453:epidemiology / Q000209:etiology; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000453:epidemiology*; D015995:Prevalence; D012306:Risk; D012307:Risk Factors; D012737:Sex Factors; D014280:Triglycerides
chemical_list: D000596:Amino Acids; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D009539:Nicotinic Acids; D014280:Triglycerides; C015240:glucose tolerance factor; D002857:Chromium