title: Leucocyte adhesion defect-1.
abstract: Leucocyte adhesion defect (LAD) is an inherited disorder of phagocytic function. It is characterized by inability of the leucocytes, in particular neutrophilis to migrate from the blood stream towards sites of inflammation. LAD -1 is characterized by the absence of b 2 integrins (CD 11 / CD18) on leucocytes. This disorder is characterized by delayed separation of the umbilical cord, recurrent severe infections, periodontitis, and delayed wound healing. We report an infant where the diagnosis was confirmed by flow cytometry.
authors.affiliation: Department of Pediatrics, PSG Institute of Medical Sciences and Research, Peelamedu, Coimbatore, Tamil Nadu, India. psg_peds@yahoo.com
authors.forename: K
authors.initials: K
authors.lastname: Jothilakshmi
authors.forename: Sugantha
authors.initials: S
authors.lastname: Priya
authors.forename: John
authors.initials: J
authors.lastname: Matthai
mesh_terms: D006801:Humans; D007223:Infant; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000175:diagnosis*; D008297:Male