Chiral transformation of cyanine dye aggregates induced by small peptides.
Three small peptides (K4, K5, and K6) with different length were designed to induce the transformation of the assembled state and the chirality of cyanine dye supramolecule. The absorption and circular dichroism (CD) results indicated that, the peptides tend to induce cyanine dye to H-aggregation, competed with Na(+) in PBS, which would induce dye to J-aggregation. Meanwhile, all three peptides could influence the chirality of both J-aggregates induced by Na(+) and H-aggregates, among which K6 could induce chiral reversion of J-aggregates. Furthermore, molecular modeling and energy calculation results have shown that the peptides with different chain length have different conformations. This might be the reason for cyanine dye to form the different chiral assembly induced by these oligo-peptide templates.
Yang
Qianfan
Q
Beijing National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry for Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing, People's Republic of China.
Xiang
Junfeng
J
Li
Qian
Q
Yan
Wenpeng
W
Zhou
Qiuju
Q
Tang
Yalin
Y
Xu
Guangzhi
G
D000042:Absorption; D000465:Algorithms; D002021:Buffers; D002232:Carbocyanines / Q000737:chemistry*; D002412:Cations; D002942:Circular Dichroism; D004396:Coloring Agents / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D008968:Molecular Conformation; D010455:Peptides / Q000737:chemistry*; D012964:Sodium / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics
D002021:Buffers; D002232:Carbocyanines; D002412:Cations; D004396:Coloring Agents; D010455:Peptides; D006859:Hydrogen; D012964:Sodium