[Lung cancer diagnosis based on urinary modified nucleoside metabolic profiling].
OBJECTIVE
To study the feasibility of modified urinary nucleosides metabolic profiling on lung cancer diagnoses.


METHODS
The modified urinary nucleosides metabolic profiling from 42 normal adults and 80 patients with lung cancer were determined by a coupled-column high performance liquid chromatography system. Partial least squares-discriminant analysis (PLS-DA) models were used to class differentiation between the lung cancer patients and controls and to discover potential biomarkers.


RESULTS
The PLS-DA model results showed that there was a clear differentiation between normal adults and lung cancers patients, with the value of prediction (Q2) equals to 0.744.


CONCLUSIONS
Modified urinary nucleosides metabolic profiling method is useful for lung cancer diagnoses.
Wang
Wen-Zhao
WZ
Metabonomics Research Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Zhao
Xin-Jie
XJ
Li
Xiang
X
Chen
Jing
J
Li
Fang-Lou
FL
Xu
Guo-Wang
GW
D000328:Adult; D015415:Biomarkers / Q000652:urine; D006801:Humans; D016018:Least-Squares Analysis; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000652:urine; D055442:Metabolome; D008954:Models, Biological; D009705:Nucleosides / Q000652:urine*
D015415:Biomarkers; D009705:Nucleosides