[Study on chemical constituents in rhizome of Securidaca inappendiculata].
OBJECTIVE
To study the chemical constituents of Securidaca inappendiculata.


METHODS
Column chromatographic techniques were applied to isolate constituents. A combination of MS and NMR spectroscopy was used to identify structures of constituents.


RESULTS
Seven compounds were isolated from the CHCl3 fraction and their structures were elucidated as 3, 4-dihydroxybezoic acid (1), 3-hydroxy-4-methoxylbenzoic acid (2), coniferaldehyde (3), 7-hydroxy-1, 2, 3, 8-tetrame thoxyxanthone (4), 1, 3, 8-trihydroxy-4-methoxyxanthone (5), 1, 3, 8-trihydroxy-2-methoxyxanth-one (6), 1, 3, 6-trihydroxy-2,7-dimethoxyxanthone (7).


CONCLUSIONS
Compounds 1-6 were isolated for the first time from the genus. The antioxidant activities of compounds 3-6 were assayed by the method of DPPH and compound 3 showed the IC50 value of 4.14 microg x mL(-1).
Shi
Lei
L
The 155th Central Hospital of PLA, Kaifeng 475003, China.
Kang
Wen-Yi
WY
D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D027343:Rhizome / Q000737:chemistry*; D031802:Securidaca / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D000975:Antioxidants; D004365:Drugs, Chinese Herbal