title: The effects of peroxisome proliferator-activated receptor-gamma agonist on a murine model of experimental allergic rhinitis.
abstract: OBJECTIVE
  To investigate the effect of rosiglitazone, a synthetic selective peroxisome proliferator-activated receptor (PPAR)-gamma agonist, for cytokine production and PPAR-gamma expression in nasal mucosa.
  
  
  METHODS
  Mice in allergic rhinitis group received ovalbumin sensitization followed by ovalbumin intranasal challenge. Mice in the rosiglitazone group received rosiglitazone treatment additionally. Various allergic responses were then assessed.
  
  
  RESULTS
  The frequency of nasal rubs and ovalbumin-specific immunoglobulin E decreased significantly in the rosiglitazone group compared with the allergic rhinitis group. The rosiglitazone group also showed that inflammation was markedly reduced by rosiglitazone administration. Immunohistochemistry showed that PPAR-gamma protein expression in nasal mucosa was enhanced in the allergic rhinitis group and the rosiglitazone group compared with control mice.
  
  
  CONCLUSIONS
  PPAR-gamma activation with rosiglitazone effectively inhibited allergic symptom development, nasal mucosal inflammation, and production of ovoalbumin-specific immunoglobulin E and Th2-type cytokine. Our results provide evidence of the therapeutic potential of PPAR-gamma agonist for the treatment of allergic rhinitis.
authors.affiliation: Department of Otolaryngology-HNS, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Eun-Ju
authors.initials: EJ
authors.lastname: Jeon
authors.forename: Seung Kyun
authors.initials: SK
authors.lastname: Lee
authors.forename: Yong-Soo
authors.initials: YS
authors.lastname: Park
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Yum
authors.forename: Chan-Soon
authors.initials: CS
authors.lastname: Park
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007073:Immunoglobulin E / Q000032:analysis; D007150:Immunohistochemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin; D047495:PPAR gamma / Q000819:agonists* / Q000032:analysis; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000276:immunology; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000627:therapeutic use*
chemical_list: D047495:PPAR gamma; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D007073:Immunoglobulin E; D010047:Ovalbumin