Interaction between interleukin-1beta -31T/C gene polymorphism and drinking and smoking habits on the risk of hepatocellular carcinoma among Japanese.
The risk of hepatocellular carcinoma (HCC) increases with the severity of hepatic inflammation. Interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha are proinflammatory cytokines with multiple biological effects and may play essential roles in inflammation-linked tumor development. We conducted a case-control study including 209 incident HCC cases and two control groups (275 hospital controls and 381 patients with chronic liver disease [CLD] without HCC) to investigate whether IL-1B and TNF-A gene polymorphisms influence HCC susceptibility with any interaction with alcohol and tobacco. By comparing HCC cases with CLD patients, we found that IL-1B -31T/C polymorphism was associated with HCC risk among never drinkers and current smokers; adjusted odds ratios (and 95% confidence intervals) for C/T and T/T genotypes compared with C/C genotype were 1.70 (0.76-3.77) and 2.46 (1.05-5.76) (P trend=0.03), respectively, among never drinkers, and 1.53 (0.60-3.99) and 2.54 (0.81-7.95) (P trend=0.11), respectively, among current smokers. Similarly, HCC risk associated with heavy alcohol intake and current smoking differed by this polymorphism among CLD patients. IL-1B -31T/C polymorphism may modify HCC risk in relation to alcohol intake or smoking.
Sakamoto
Tatsuhiko
T
Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Higaki
Yasuki
Y
Hara
Megumi
M
Ichiba
Masayoshi
M
Horita
Mikako
M
Mizuta
Toshihiko
T
Eguchi
Yuichiro
Y
Yasutake
Tsutomu
T
Ozaki
Iwata
I
Yamamoto
Kyosuke
K
Onohara
Shingo
S
Kawazoe
Seiji
S
Shigematsu
Hirohisa
H
Koizumi
Shunzo
S
Tanaka
Keitaro
K
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D007564:Japan; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000235:genetics*
D053583:Interleukin-1beta