A role for anti-transglutaminase 2 autoantibodies in the pathogenesis of coeliac disease?
Coeliac disease is an autoimmune-mediated disorder with both innate and adaptive immune components. The disease is triggered by dietary gluten, which provokes the development of a massive immune reaction leading to the destruction of the small-intestinal mucosal morphology and intestinal dysfunction. Besides the typical small-bowel symptoms extraintestinal manifestations may also arise in a subset of coeliac disease patients. In addition, gluten evokes the production of antibodies mainly targeting deamidated gluten peptides or transglutaminase 2. Although coeliac disease has traditionally been regarded as a T cell-mediated disorder, this review discusses the role of the gluten-induced disease-specific anti-transglutaminase 2-autoantibodies in the pathogenesis of the disease.
Lindfors
K
K
Paediatric Research Centre, Medical School, University of Tampere and Tampere University Hospital, 33014, Tampere, Finland.
Kaukinen
K
K
Mäki
M
M
D001323:Autoantibodies / Q000276:immunology* / Q000494:pharmacology; D002446:Celiac Disease / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D019204:GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000276:immunology*; D005983:Glutens / Q000009:adverse effects / Q000276:immunology; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000037:antagonists & inhibitors / Q000276:immunology*
D001323:Autoantibodies; D005983:Glutens; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins