title: Two cases of burning mouth syndrome treated with olanzapine.
abstract: Two case reports of patients suffering from burning mouth syndrome (BMS), a type of somatoform disorder, who were treated with olanzapine are discussed. One case was a 54-year-old female with BMS who failed to respond to milnacipran treatment. Olanzapine (2.5 mg/day) brought about dramatic improvement in the patient's symptoms, and thereafter milnacipran withdrawal further eliminated her symptoms. The second case was a 51-year-old male with BMS who failed to respond to paroxetine treatment. Olanzapine (2.5 mg/day) was added to the treatment regimen and increased to 5.0 mg/day the following week. The patient noted a reduction in symptoms and continued to live normally thereafter without experiencing severe symptoms. These findings suggest that olanzapine may be useful in the treatment of BMS.
authors.affiliation: Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyusyu, Japan. nueda@med.uoeh-u.ac.jp
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Ueda
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kodama
authors.forename: Hikaru
authors.initials: H
authors.lastname: Hori
authors.forename: Wakako
authors.initials: W
authors.lastname: Umene
authors.forename: Atsuko
authors.initials: A
authors.lastname: Sugita
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakano
authors.forename: Reiji
authors.initials: R
authors.lastname: Yoshimura
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D002054:Burning Mouth Syndrome / Q000188:drug therapy* / Q000523:psychology; D003521:Cyclopropanes / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000078764:Milnacipran; D000077152:Olanzapine; D017374:Paroxetine / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D003521:Cyclopropanes; D001569:Benzodiazepines; D017374:Paroxetine; D000078764:Milnacipran; D000077152:Olanzapine