title: Habitual fish consumption does not prevent a decrease in LCPUFA status in pregnant women (the Seychelles Child Development Nutrition Study).
abstract: Information on the status of long-chain polyunsaturated fatty acids (LCPUFAs) in pregnancy and breast milk in very high fish-eating populations is limited. The aim of this study was to examine dietary intake and changes in fatty acid status in a population of pregnant women in the Republic of Seychelles. Serum docosahexaenoic acid (DHA) decreased significantly between 28-week gestation and delivery (n=196). DHA status did not correlate significantly with length of gestation and was not associated with self-reported fish intake, which was high at 527 g/week. In breast milk, the ratio of DHA to arachidonic acid (AA) was consistent with those observed in other high fish-eating populations. Overall the data suggest that high exposure to LCPUFAs from habitual fish consumption does not prevent the documented decrease in LCPUFA status in pregnancy that occurs as a result of foetal accretion in the third trimester of pregnancy.
authors.affiliation: Northern Ireland Centre for Food and Health (NICHE), Department of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK. mp.bonham@ulster.ac.uk
authors.forename: M P
authors.initials: MP
authors.lastname: Bonham
authors.forename: E M
authors.initials: EM
authors.lastname: Duffy
authors.forename: J M W
authors.initials: JM
authors.lastname: Wallace
authors.forename: P J
authors.initials: PJ
authors.lastname: Robson
authors.forename: G J
authors.initials: GJ
authors.lastname: Myers
authors.forename: P W
authors.initials: PW
authors.lastname: Davidson
authors.forename: T W
authors.initials: TW
authors.lastname: Clarkson
authors.forename: C F
authors.initials: CF
authors.lastname: Shamlaye
authors.forename: J J
authors.initials: JJ
authors.lastname: Strain
mesh_terms: D000328:Adult; D000818:Animals; D002657:Child Development / Q000502:physiology; D004032:Diet; D004281:Docosahexaenoic Acids / Q000032:analysis / Q000097:blood; D004537:Eicosanoic Acids / Q000032:analysis / Q000097:blood; D002149:Energy Intake / Q000502:physiology*; D005231:Fatty Acids, Unsaturated / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D005260:Female; D005399:Fishes; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008895:Milk, Human / Q000737:chemistry / Q000378:metabolism; D009747:Nutritional Physiological Phenomena; D049590:Postpartum Period / Q000097:blood / Q000378:metabolism; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood / Q000378:metabolism; D017747:Seafood / Q000032:analysis*; D012750:Seychelles
chemical_list: D004537:Eicosanoic Acids; D005231:Fatty Acids, Unsaturated; D004281:Docosahexaenoic Acids; C094477:arachidic acid