Anti-RO anti-LA anti-RNP antibodies and eletrocardiogram's PR interval in adult patients with systemic lupus erythematosus.
BACKGROUND
Children born from mothers with anti-Ro La or RNP autoantibodies may develop neonatal lupus. One of the manifestations of neonatal lupus is congenital atrio ventricular block.


OBJECTIVE
To study EKG PR interval in adult systemic lupus erythematosus (SLE) patients with anti-Ro anti-La and anti-RNP autoantibodies.


METHODS
PR intervals and the presence of anti-Ro La and RNP antibodies were studied in 61 SLE patients and compared with 61 controls.


RESULTS
36.6% of SLE patients were anti-Ro positive 20% were anti-La and 22.9% were anti-RNP positive. All studied PR intervals were within normal limits (upper limit of 0.2 sec). We did not find any association between PR interval length and the presence of anti-Ro (p=0.54) anti-La (p=0.45) or anti-RNP autoantibodies (p=0.36).


CONCLUSIONS
The presence of anti-Ro La and RNP autoantibodies does not influence PR interval in adult SLE patients.
Costa
Militino
M
Servico de Reumatologia do Hospital Universitario Evangelico de Curitiba-PR Brasil.
Gameiro Silva
Marilia Barreto
MB
Silva
José Antonio
JA
Skare
Thelma L
TL
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D055517:snRNP Core Proteins
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D001324:Autoantigens; C035356:SS-A antibodies; C035357:SS-B antibodies; D055517:snRNP Core Proteins