The risk of cancer progression in women with gynecological malignancies and thrombophilic polymorphisms: a pilot case-control study.
Cancer produces a hypercoagulable state, which might lead to thrombosis, and on contrary, unprovoked venous thromboembolism might be the manifestation of an occult cancer. In this pilot case-control study, we assessed the risk of gynecological malignant diseases related to the presence of the factor V Leiden and prothrombin G20210A polymorphisms. Fifty-two women underwent an operation for gynecological malignancy and were enrolled in the study. Women who underwent an operation for gynecological nonmalignant disease in the same days of cases were considered as controls. The presence of factor V Leiden and prothrombin G20210A was assessed in case and control groups. In all, 7 out of 52 cases were carriers of the 2 polymorphisms compared with 20 out of 198 controls (odds ratio = 1.3; 95% confidence interval, 0.6-3.0). The results were also similar when the risk was considered separately for the site of cancer. As for advanced and metastatic malignancies, the odds ratios were 2.3 (95% confidence interval, 0.9-6.0) and 3.3 (95% confidence interval, 1.0-11), respectively, compared to noncancer patients. When these 2 groups were compared to nonadvanced cancer group, the odds ratios for carriers of polymorphisms were 2.7 (95%confidence interval, 0.7-11.0) and 3.9 (95%confidence interval, 0.8-18.6) for advanced cancer and metastatic malignancies, respectively. Women with factor V Leiden or prothrombin G20210A polymorphisms who developed gynecological malignancy might present with a higher stage of cancer at the time of surgery. Larger case-control studies in similar cohort of patients are needed to confirm these findings.
Tormene
Daniela
D
Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Padua, Italy. daniela.tormene@unipd.it
Beltramello
Paola
P
Perlati
Marica
M
Brandolin
Barbara
B
Barbar
Sofia
S
De Toffoli
Giuseppe
G
Simioni
Paolo
P
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D018450:Disease Progression; D005165:Factor V / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005833:Genital Neoplasms, Female / Q000097:blood / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011516:Prothrombin / Q000235:genetics*; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000097:blood / Q000235:genetics* / Q000473:pathology
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin