Novel alleles at the HLA-DRB1 and -DQB1 loci.
Twelve novel human leukocyte antigen class II alleles are described; eight DRB1 alleles and four DQB1 alleles. Nine of the variants are single nucleotide substitutions from their most homologous allele, of which six result in amino acid changes (DRB1*0459, *1156 and *1522; DQB1*0205, *0320 and *0321) and three are silent substitutions (DRB1*030105 and *040304, and DQB1*030104). The remaining alleles (DRB1*0906, *1464 and *1468) differ from their most similar alleles by two to three nucleotide substitutions which alter one to two amino acids.
Lazaro
A M
AM
Department of Oncology and Pediatrics, Georgetown University Medical Center, Washington, DC, USA.
Xiao
Y
Y
Masaberg
C
C
Lebeck
L
L
Ng
J
J
Hurley
C K
CK
Posch
P E
PE
D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics; D005819:Genetic Markers; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans
D005819:Genetic Markers; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains