It is the plasma renin activity level that counts, not stoichiometry.
Sealey
Jean E
JE
Laragh
John H
JH
D000577:Amides / Q000627:therapeutic use*; D005650:Fumarates / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000201:enzymology*; D020128:Inhibitory Concentration 50; D012083:Renin / Q000097:blood*; D000092502:Renin Inhibitors
D000577:Amides; D005650:Fumarates; D012083:Renin; D000092502:Renin Inhibitors; C446481:aliskiren