Co-administration of ropinirole and domperidone during rapid dose escalation of the dopamine agonist.
In patients naive to dopaminergic therapy, reducing the side-effects associated with dopamine agonist treatment will permit faster titration to effective therapeutic doses. The primary aim of this study was to compare the incidence of dopaminergic side-effects in parkinsonian patients undergoing fast titration with ropinirole under domperidone cover with that of patients undergoing slow titration with matched domperidone placebo. Patients in the former group experienced nausea on significantly fewer days than patients in the latter group. The fast-titration regimen with domperidone cover was well tolerated and allowed ropinirole to be introduced quickly.
Stocchi
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Department of Neurological Science, University "la Sapienza" Roma and Neuromed, Pozzilli (IS), Rome, Italy.
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