title: Tardive seizure and antibiotics: case reports and review of the literature.
abstract: Tardive seizure is a serious adverse reaction of electroconvulsive therapy (ECT). However, it was rarely reported in ECT sessions for psychiatric patients who needed concurrent antibiotic treatments. We present 2 cases of patients with schizophrenia who manifested a catatonic syndrome and were indicated for ECT, along with antibiotic therapies for infectious diseases with piperacillin and cefotiam, respectively. The beta-lactam antibiotics are reported to induce convulsions caused by the suppression of inhibitory GABAergic functions. In addition, there is a report on prolonged ECT seizure related to ciprofloxacin, which has an epileptogenic property with a similar action to beta-lactam antibiotics. Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.
authors.affiliation: Department of Psychiatry, Tokyo Metropolitan Toshima Hospital, Tokyo, Japan. takahiro-s@toshima-hp.metro.tokyo.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Saito
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Nakamura
authors.forename: Michiko
authors.initials: M
authors.lastname: Watari
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Isse
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D004565:Electroconvulsive Therapy / Q000009:adverse effects*; D004569:Electroencephalography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000150:complications; D010878:Piperacillin / Q000009:adverse effects / Q000627:therapeutic use; D011015:Pneumonia, Aspiration / Q000188:drug therapy / Q000209:etiology; D018967:Risperidone / Q000627:therapeutic use; D012560:Schizophrenia, Catatonic / Q000188:drug therapy / Q000628:therapy; D012563:Schizophrenia, Paranoid / Q000150:complications / Q000628:therapy; D012640:Seizures / Q000139:chemically induced* / Q000209:etiology*; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D014150:Antipsychotic Agents; D018967:Risperidone; D010878:Piperacillin