Augmented muscle vasodilatory responses in obese children with Glu27 beta-2-adrenoceptor polymorphism.
This study examined forearm vasodilatation during mental challenge and exercise in 72 obese children (OC; age = 10 +/- 0.1 years) homozygous with polymorphism in the allele 27 of the beta-2-adrenoceptors: Gln27 (n = 61) and Glu27 (n = 11). Forearm blood flow was recorded during 3 min of each using the Stroop color-word test (MS) and handgrip isometric exercise. Baseline hemodynamic and vascular measurements were similar. During the MS, peak forearm vascular conductance was significantly greater in group Glu27 (Delta = 0.35 +/- 0.4 vs. 0.12 +/- 0.1 units, respectively, p = .042). Similar results were found during exercise (Delta = 0.64 +/- 0.1 vs. 0.13 +/- 0.1 units, respectively, p = .035). Glu27 OC increased muscle vasodilatory responsiveness upon the MS and exercise.
da Silva
Alexandre G
AG
Dept. of Endocrinology, University of Sao Paulo, Brazil.
Ribeiro
Mauricio M
MM
Trombetta
Ivani C
IC
Nicolau
Christiane
C
Frazzatto
Eliana
E
Guazzelli
Isabel
I
Matos
Luciana N J
LN
Halbern
Alfredo
A
Negrão
Carlos E
CE
Villares
Sandra M F
SM
D000886:Anthropometry; D015992:Body Mass Index; D002648:Child; D002669:Child Welfare; D003071:Cognition; D015444:Exercise; D005080:Exercise Test; D005260:Female; D005542:Forearm / Q000098:blood supply; D018737:Hand Strength; D006439:Hemodynamics; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology; D011110:Polymorphism, Genetic; D011594:Psychometrics; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics* / Q000378:metabolism; D013315:Stress, Psychological; D014664:Vasodilation
D018343:Receptors, Adrenergic, beta-2