Functional connectivity of the sensorimotor area in naturally sleeping infants.
Patterns of cortical functional connectivity in normal infants were examined during natural sleep by observing the time course of very low frequency oscillations. Such oscillations represent fluctuations in blood oxygenation level and cortical blood flow thus allowing computation of neurophysiologic connectivity. Structural and resting-state information were acquired for 11 infants, with a mean age of 12.8 months, using a GE 1.5 T MR scanner. Resting-state data were processed and significant functional connectivity within the sensorimotor area was identified using independent component analysis. Unilateral functional connectivity in the developing sensory-motor cortices was observed. Power spectral analysis showed that slow frequency oscillations dominated the hemodynamic signal at this age, with, on average, a peak frequency for all subjects of 0.02 Hz. Our data suggest that there is more intrahemispheric than interhemispheric connectivity in the sensorimotor area of naturally sleeping infants. This non-invasive imaging technique, developed to allow reliable scanning of normal infants without sedation, enabled computation of neurophysiologic connectivity for the first time in naturally sleeping infants. Such techniques permit elucidation of the role of slow cortical oscillations during early brain development and may reveal critical information regarding the normative development and lateralization of brain networks across time.
Liu
Wen-Ching
WC
Department of Radiology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, 150 Bergen Street, Newark, NJ 07103, USA. wliu@umdnj.edu
Flax
Judy F
JF
Guise
Kevin G
KG
Sukul
Vishad
V
Benasich
April A
AA
D000200:Action Potentials / Q000502:physiology; D000375:Aging / Q000502:physiology*; D001683:Biological Clocks / Q000502:physiology; D001931:Brain Mapping; D002536:Cerebral Arteries / Q000033:anatomy & histology / Q000254:growth & development; D002560:Cerebrovascular Circulation / Q000502:physiology; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000033:anatomy & histology / Q000098:blood supply / Q000254:growth & development*; D009415:Nerve Net / Q000033:anatomy & histology / Q000098:blood supply / Q000254:growth & development; D009434:Neural Pathways / Q000033:anatomy & histology / Q000098:blood supply / Q000254:growth & development; D010101:Oxygen Consumption / Q000502:physiology; D012890:Sleep / Q000502:physiology*; D013003:Somatosensory Cortex / Q000033:anatomy & histology / Q000098:blood supply / Q000254:growth & development*