Endometrial effects of letrozole and clomiphene citrate in women with polycystic ovary syndrome using spiral artery Doppler.
OBJECTIVE
To compare the effects of letrozole and clomiphene citrate (CC) on endometrial response in PCOS using subendometrial spiral artery Doppler.


METHODS
Fifty consecutive patients of anovulatory PCOS were recruited. Twenty-five patients (58 cycles) received 2.5-5 mg of letrozole; 25 patients (56 cycles) received 50-100 mg of CC (both orally on days 5-9 of menses).


METHODS
number of dominant follicles, endometrial thickness (ET), spiral artery resistance index (RI) and pulsatility index (PI) and pregnancy rate.


RESULTS
The mean number of dominant follicles in letrozole group and CC groups was 1.63+/-1.02 and 1.62+/-0.96, respectively (P>0.05). The mean mid cycle ET was 6.9+/-0.74 mm in letrozole group and 5.9+/-0.53 mm in CC group (P<0.05). In letrozole and CC groups, the mean RI of spiral artery were 0.63+/-0.05 and 0.79+/-0.09, respectively, and the mean PI of spiral artery were 1.19+/-0.06 and 1.55+/-0.13, respectively. Both RI and PI in the letrozole group showed significant lower impedance compared to CC group (P<0.05). Pregnancy rate per cycle was 19% (11/58) in the letrozole group and 12.5% (7/56) in the CC group (P>0.05).


CONCLUSIONS
The effect of letrozole showed a significantly better endometrial response compared to CC.
Baruah
Jinee
J
Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Room No. 3085, 3rd Floor, Teaching Block, New Delhi, India.
Roy
K K
KK
Rahman
S M
SM
Kumar
Sunesh
S
Sharma
J B
JB
Karmakar
Debjyoti
D
D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use*; D004717:Endometrium / Q000098:blood supply / Q000000981:diagnostic imaging / Q000187:drug effects*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D006801:Humans; D000077289:Letrozole; D009570:Nitriles / Q000627:therapeutic use*; D006080:Ovarian Follicle / Q000000981:diagnostic imaging / Q000187:drug effects; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011247:Pregnancy; D011446:Prospective Studies; D014230:Triazoles / Q000627:therapeutic use*; D018615:Ultrasonography, Doppler, Color
D005300:Fertility Agents, Female; D009570:Nitriles; D014230:Triazoles; D002996:Clomiphene; D000077289:Letrozole