[Effects of lipid dysmetabolism in rats induced by high fat diet on glycometabolism and inflammatory factor].
OBJECTIVE
To investigate the changes of glycometabolism and inflammatory factors of the lipid dysmetabolism in rats induced by high fat diet.


METHODS
20 male SD rats were divided into the control group and the lipid dysmetabolism group. The rats were administrated the high fat diet for 17 weeks, then body weight, and the contents of TC, TG, HDL-C, TNF-alpha and IL-6 were measured, and the contents of serum FPG, FINS and hs-CRP were detected at the 5th, 11th and 17th weeks respectively.


RESULTS
In comparison with the control groups, the serum contents of TC, TG, FINS, hs-CRP and IL-6 were increased significantly in the lipid dysmetabolism groups, and the ISI levels were decreased in thelipid dysmetabolism groups (P < 0.05).


CONCLUSIONS
The rats were induced by high fat diet to develope the lipid dysmetabolism, the lipid dysmetabolism could induce of the FINS increases and decreases of the ISI.
Wang
Yanli
Y
School of Public Health, Southeast University, Nanjing 210009, China.
Zhai
Chengkai
C
Chen
Han
H
Wang
Xiaofei
X
D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D044882:Glucose Metabolism Disorders / Q000378:metabolism*; D006949:Hyperlipidemias / Q000209:etiology / Q000378:metabolism*; D007328:Insulin / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004041:Dietary Fats; D007328:Insulin; D015850:Interleukin-6; D002097:C-Reactive Protein