Enalapril-induced cough is associated with non-severe heart failure.
The incidence of enalapril-induced cough was evaluated in 199 patients with congestive heart failure. Cough was more frequent in class I or II patients (28%) than in class III (4.1%, p<0.01) and class IV (0%, p<0.01) patients. Brain natriuretic peptide level was lower in patients in the cough (+) group than in the cough (-) group (170+/-107 vs. 538+/-637 pg/ml, p<0.01). The incidence of enalapril-induced cough is low in patients with severe congestive heart failure and a cough can be a marker of non-severe heart failure.
Sadanaga
Tsuneaki
T
Yoshimura
Michihiro
M
Sakamoto
Tomohiro
T
Sumida
Hitoshi
H
Ogawa
Hisao
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D015415:Biomarkers; D003371:Cough / Q000139:chemically induced* / Q000453:epidemiology; D004656:Enalapril / Q000009:adverse effects*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D000806:Angiotensin-Converting Enzyme Inhibitors; D015415:Biomarkers; D004656:Enalapril