Fine-mapping at the HTR2A locus reveals multiple episodic memory-related variants.
A functional polymorphism (His452Tyr) in the gene encoding the serotonin 2A receptor (HTR2A) has been previously associated with human episodic memory performance and with differences in brain volume in memory-related brain regions. Here we present data obtained through imputation and fine-mapping showing that multiple loci within HTR2A are significantly associated with human memory performance independently of the His452Tyr polymorphism. Our data support the existence of multiple memory-related loci within HTR2A.
Sigmund
Jessica C
JC
Division of Molecular Psychology, University of Basel, Basel, Switzerland. jessica.sigmund@unibas.ch
Vogler
Christian
C
Huynh
Kim-Dung
KD
de Quervain
Dominique J-F
DJ
Papassotiropoulos
Andreas
A
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006639:Histidine / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics; D014443:Tyrosine / Q000235:genetics; D014706:Verbal Learning / Q000502:physiology; D055815:Young Adult
D044402:Receptor, Serotonin, 5-HT2A; D014443:Tyrosine; D006639:Histidine