Cdh1: a master G0/G1 regulator.
APC/C(Cdh1) controls the G0 and G1 phases of the cell cycle. Using a conditional knockout of the Cdh1 coding gene Fizzy-related (Fzr), a new study demonstrates that Cdh1 is essential for viability and that it functions as a tumour suppressor by preventing genomic instability.
Skaar
Jeffrey R
JR
Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, NY 10016, USA.
Pagano
Michele
M
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D064200:Cdh1 Proteins; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism; D002470:Cell Survival; D016193:G1 Phase / Q000502:physiology*; D016147:Genes, Tumor Suppressor; D042822:Genomic Instability; D051379:Mice; D018345:Mice, Knockout; D016192:Resting Phase, Cell Cycle / Q000502:physiology*; D043743:Ubiquitin-Protein Ligase Complexes / Q000235:genetics / Q000378:metabolism*
D064200:Cdh1 Proteins; D018797:Cell Cycle Proteins; C577585:Fzr1 protein, mouse; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome