title: Partial recovery of delayed graft function due to cholesterol emboli after renal transplantation.
abstract: A 65-year-old man who received a deceased renal allograft in September 2001. The donor of the allograft was a 54-year-old hypertensive man who expired from intracerebral hemorrhage. Atheroma with hard plaques was present in both renal arteries and aortic patches. After vascular anastomosis and clamp release, the allograft recoloration was inadequate, and the patient remained anuric. Computerized tomography scan demonstrated disseminated infarction areas, suggesting cholesterol emboli, which was confirmed later by a graft biopsy. As approximately 50% of the renal parenchyma was perfused, graft nephrectomy was not indicated and dialysis was restarted. Diuresis was over 3000 ml/day and serum creatinine decreased and stabilized at 360 micromol/L by the 32nd postoperative day. The allograft supported the patient for only two years, and he eventually was successfully retransplanted in June 2003. We believe that delayed graft function due to cholesterol emboli disease may be reversible if areas of infarction are not too large.
authors.affiliation: Department of Nephrology, Transplantation and Peritoneal Dialysis, Montpellier University Medical School, Montpellier, France.
authors.forename: C
authors.initials: C
authors.lastname: Ackoundou-N'Guessan
authors.forename: J
authors.initials: J
authors.lastname: Bismuth
authors.forename: S
authors.initials: S
authors.lastname: Canet
authors.forename: F
authors.initials: F
authors.lastname: Iborra
authors.forename: G
authors.initials: G
authors.lastname: Mourad
mesh_terms: D000328:Adult; D000368:Aged; D002102:Cadaver; D002291:Carcinoma, Papillary / Q000601:surgery; D017700:Embolism, Cholesterol / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007680:Kidney Neoplasms / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D014019:Tissue Donors; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous; D016896:Treatment Outcome