Is the acceptable daily intake as presently used an axiom or a dogma?
International scientific committees, regional scientific committees such as those of the European Union, and national regulatory agencies generally use the uncertainly factor approach for establishing acceptable or tolerable intakes of substances that exhibit thresholds of toxicity. No observed adverse effect levels (NOAELs) are identified in the critical studies to which appropriate uncertainly factors are applied to allocate acceptable daily intake (ADI). This paper discusses the different steps of the risk assessment process considered for decades worldwide a pragmatic approach to allocate safe doses, yet in need of improvements during the extrapolation phase which could increase the confidence level of the work performed by risk assessors.
Galli
Corrado Lodovico
CL
Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan 20133, Italy. corrado.galli@unimi.it
Marinovich
Marina
M
Lotti
Marcello
M
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005502:Food / Q000009:adverse effects; D006801:Humans; D019055:No-Observed-Adverse-Effect Level; D018570:Risk Assessment / Q000592:standards*; D013045:Species Specificity; D009626:Terminology as Topic