title: Facial symmetry in protein self-assembly.
abstract: Amyloids are self-assembled protein architectures implicated in dozens of misfolding diseases. These assemblies appear to emerge through a "selection" of specific conformational "strains" which nucleate and propagate within cells to cause disease. The short Abeta(16-22) peptide, which includes the central core of the Alzheimer's disease Abeta peptide, generates an amyloid fiber which is morphologically indistinguishable from the full-length peptide fiber, but it can also form other morphologies under distinct conditions. Here we combine spectroscopic and microscopy analyses that reveal the subtle atomic-level differences that dictate assembly of two conformationally pure Abeta(16-22) assemblies, amyloid fibers and nanotubes, and define the minimal repeating unit for each assembly.
authors.affiliation: Center for the Analysis of Supramolecular Self-assemblies, Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA.
authors.forename: Anil K
authors.initials: AK
authors.lastname: Mehta
authors.forename: Kun
authors.initials: K
authors.lastname: Lu
authors.forename: W Seth
authors.initials: WS
authors.lastname: Childers
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.forename: Steven N
authors.initials: SN
authors.lastname: Dublin
authors.forename: Jijun
authors.initials: J
authors.lastname: Dong
authors.forename: James P
authors.initials: JP
authors.lastname: Snyder
authors.forename: Sai Venkatesh
authors.initials: SV
authors.lastname: Pingali
authors.forename: Pappannan
authors.initials: P
authors.lastname: Thiyagarajan
authors.forename: David G
authors.initials: DG
authors.lastname: Lynn
mesh_terms: D000682:Amyloid / Q000737:chemistry*; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D006860:Hydrogen Bonding; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D043942:Nanotubes / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D010446:Peptide Fragments / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013055:Spectrophotometry, Infrared; D013816:Thermodynamics; D014961:X-Ray Diffraction
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C417223:amyloid beta-protein (16-22)