title: Manic episode with psychotic symptoms in a patient with Parkinson's disease treated by subthalamic nucleus stimulation: improvement on switching the target.
abstract: Manic symptoms have been reported as adverse effects of bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease. In previous reports, manic symptoms were described as transient, not associated with psychotic features, and improved spontaneously or with medical adjustments. The medial part of the STN seems to play a key role in the occurrence of these manic symptoms. We report the case of a manic episode with psychotic symptoms in a patient with Parkinson's disease treated by STN DBS, which improved with a change in the stimulated target. This case demonstrates the efficacy of switching the stimulation target against a manic episode with psychotic features secondary to DBS.
authors.affiliation: Department of Psychiatry, Robert Debré Hospital, University of Reims, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Raucher-Chéné
authors.forename: Claire-Lise
authors.initials: CL
authors.lastname: Charrel
authors.forename: Anne Doe
authors.initials: AD
authors.lastname: de Maindreville
authors.forename: Frédéric
authors.initials: F
authors.lastname: Limosin
mesh_terms: D001714:Bipolar Disorder / Q000209:etiology / Q000628:therapy*; D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000628:therapy*; D011618:Psychotic Disorders / Q000209:etiology / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000502:physiology / Q000528:radiation effects*