title: A comparative evaluation of the speed of kill and duration of efficacy against weekly infestations with fleas on cats treated with fipronil-(S)-methoprene or metaflumizone.
abstract: Spot-on formulations of metaflumizone and a combination of fipronil-(S)-methoprene were evaluated in adult cats to determine the duration of 24- and 48-hour efficacy and short-term speed of kill against adult cat fleas, Ctenocephalides felis felis. Speed of kill efficacies (at 12, 18, 24, and 48 hours) were assessed against existing (day -1) infestations and against infestations at day 7, and efficacy was assessed 24 and 48 hours after weekly flea infestations through day 42. Cats treated with fipronil-(S)-methoprene had significantly (P<.01) fewer fleas than those treated with metaflumizone at 12 and 18 hours after treatment (day 0) and on the day 7 infestations. Fipronil-(S)-methoprene-treated cats also had significantly (P<.05) fewer fleas than metaflumizone-treated cats for all 24-hour counts from initial treatment on day 0 through infestation day 42 and for the 48-hour counts on day 28 through day 42.
authors.affiliation: UMR181 Physiopathologie et Toxicologie Expérimentales, INRA, ENVT, Ecole Nationale Véterinaire, Toulouse, France.
authors.forename: M
authors.initials: M
authors.lastname: Franc
authors.forename: F
authors.initials: F
authors.lastname: Beugnet
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy* / Q000517:prevention & control*; D002415:Cats; D004478:Ectoparasitic Infestations / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D007306:Insecticides / Q000627:therapeutic use*; D008297:Male; D008726:Methoprene / Q000627:therapeutic use; D011720:Pyrazoles / Q000627:therapeutic use; D012664:Semicarbazones / Q000627:therapeutic use; D005423:Siphonaptera; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007306:Insecticides; D011720:Pyrazoles; D012664:Semicarbazones; C528570:metaflumizone; D008726:Methoprene; C082360:fipronil