[Serum adiponectin and leptin levels and bone mineral density in 232 men].
OBJECTIVE
To investigate whether adiponectin and leptin levels are associated with bone mineral density (BMD) in 232 men (20~80 years old).


METHODS
Serum adiponectin and leptin levels were determined by enzyme-linked immunosorbentassay (ELISA). BMD at various sites was determined using dual energy x-ray absorptiometry (DXA).


RESULTS
Adiponectin was negatively correlated with body fat, while leptin had a positively correlation. Significant negative correlations between adiponectin and BMD were found, which remained significant after adjustment of age and body fat. In the multiple linear stepwise regression analysis, adiponectin but not leptin, was independent predictor of BMD.


CONCLUSIONS
Adiponectin was an independent predictor of BMD in Chinese men. Adiponectin may exert a negative effect on bone mass.
Yang
Ling-Feng
LF
Institute of Endocrinology and Metabolism, Second Xiangya Hospital, Central South University, Changsha 410011, China. yanghuzhang123@tom.com
Xie
Hui
H
Yuan
Ling-Qing
LQ
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015519:Bone Density; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis
D052242:Adiponectin; D020738:Leptin