title: First detection of the OXA-40 carbapenemase in P. aeruginosa isolates, located on a plasmid also found in A. baumannii.
abstract: The aim of this work was to carry out the molecular investigation of the OXA-40 carbapenemase detected in two isolates of Pseudomonas aeruginosa resistant to imipenem. The sequence showed 100% of homology with the gene previously described in Acinetobacter baumannii. Hybridization experiments located the gene on a plasmid also found in the OXA-40 control strain of A. baumannii.
authors.affiliation: Departamento Inmunología, Facultad de Medicina y Odontología, Universidad del País Vasco, Aptdo. 699, 48080 Bilbao, Spain. elena.sevillano@ehu.es
authors.forename: E
authors.initials: E
authors.lastname: Sevillano
authors.forename: L
authors.initials: L
authors.lastname: Gallego
authors.forename: J M
authors.initials: JM
authors.lastname: García-Lobo
mesh_terms: D040981:Acinetobacter baumannii / Q000201:enzymology* / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D015780:Carbapenems / Q000494:pharmacology; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D010957:Plasmids / Q000235:genetics; D011550:Pseudomonas aeruginosa / Q000201:enzymology* / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D015780:Carbapenems; D004269:DNA, Bacterial; D001618:beta-Lactamases; C063912:carbapenemase