Sopungyangjae-tang inhibits development of dermatitis in nc/nga mice.
Sopungyangjae-Tang (SYT) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study was to confirm whether or not SYT has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SYT was administered orally to Nc/Nga mice, which led to the remarkable suppression of the development of dermatitis, as determined by a histological examination and the serum IgE levels. Moreover, SYT inhibited the production of thymus- and activation-regulated chemokine (TARC) and its mRNA expression in a keratinocyte cell line, HaCaT, which had been stimulated with tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Activation of the nuclear factor-kappaB (NF-kappaB) or activator protein-1 (AP-1) is one of the key steps in the signaling pathways mediating induction of TARC. In this study, SYT selectively suppressed NF-kappaB activation, which may be essential for TARC expression in TNF-alpha/IFN-gamma treated keratinocytes. The inhibitory effect of SYT on NF-kappaB activation and TARC production might be associated with the anti-dermatitic effects of SYT.
Pokharel
Yuba Raj
YR
BK21 Project Team, College of Pharmacy and Department of Pathology, College of Medicine, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759, Department of Prescription, College of Oriental Medicine, Daegu Haany University, Daegu 706-060 and College of Biomedical Laboratory Science, Konyang University, Daejeon, South Korea.
Lim
Sung Chul
SC
Kim
Sang Chan
SC
Heo
Tae-Hwe
TH
Choi
Hoo Kyun
HK
Kang
Keon Wook
KW