Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet.
Dietary factors influence BDNF in animal studies, but there is no comparable data in clinical populations. We examined the effect of a dietary intervention on BDNF serum levels in 67 DSM-IV schizophrenic outpatients (51 males and 16 females). Two groups were assessed in a cross-sectional study: one on a hypocaloric diet (HD) and the other not on a hypocaloric diet. Weight, height and BMI data were collected concurrently with 5-ml blood sampling of each subject. BDNF levels were measured with a sandwich-ELISA. The blood sample was obtained a minimum of one month after the exposure to dietary intervention. Serum BDNF levels were significantly higher in patients on the HD (p=0.023). Additional research examining the interaction among patterns of nutritional food behavior and underlying physiopathology may result in insights upon which evidence-based decisions regarding dietary interventions can be made in people identified with major psychiatric disorders, such as schizophrenia.
Guimarães
Lísia Rejane
LR
Psychiatry Post-Graduation Program, Universidade Federal do Rio Grande do Sul (UFRGS), Schizophrenia Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Jacka
Felice N
FN
Gama
Clarissa Severino
CS
Berk
Michael
M
Leitão-Azevedo
Carmen Lúcia
CL
Belmonte de Abreu
Martha Guerra
MG
Lobato
Maria Inês
MI
Andreazza
Ana Cristina
AC
Ceresér
Keila Maria
KM
Kapczinski
Flávio
F
Belmonte-de-Abreu
Paulo
P
D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D031204:Caloric Restriction / Q000523:psychology*; D003430:Cross-Sectional Studies; D004435:Eating / Q000523:psychology; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D012044:Regression Analysis; D012559:Schizophrenia / Q000097:blood*; D012565:Schizophrenic Psychology
D019208:Brain-Derived Neurotrophic Factor