Integrating host genomics with surveillance for invasive bacterial diseases.
We tested the feasibility of linking Active Bacterial Core surveillance, a prospective, population-based surveillance system for invasive bacterial disease, to a newborn dried blood spot (nDBS) repository. Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease.
Crawford
Dana C
DC
Vanderbilt University, Nashville, Tennessee, USA.
Zimmer
Shanta M
SM
Morin
Craig A
CA
Messonnier
Nancy E
NE
Lynfield
Ruth
R
Yi
Qian
Q
Shephard
Cynthia
C
Wong
Michelle
M
Rieder
Mark J
MJ
Livingston
Robert J
RJ
Nickerson
Deborah A
DA
Whitney
Cynthia G
CG
Lingappa
Jairam
J
D016022:Case-Control Studies; D002675:Child, Preschool; D005240:Feasibility Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D051916:Membrane Cofactor Protein / Q000235:genetics; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000235:genetics*; D015997:Neonatal Screening; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011159:Population Surveillance; D012189:Retrospective Studies
C497857:CD46 protein, human; D051916:Membrane Cofactor Protein