A positron-probe system for arterial input function quantification for positron emission tomography in humans.
We developed an intra-arterial positron-probe (beta(+)-probe) system to measure the arterial time-activity concentration in humans for quantitative compartmental modeling of positron emission tomography studies. Performance was characterized in vitro, by using a uniform phantom to calculate dead time, linearity, and absolute detector sensitivity. In vitro evaluations in a uniform phantom showed a system dead time of 2.5 micros, linear regression between measured and true count rates with R(2)=0.999, and detector sensitivity of 6.9-7.0 counts/s kBq(-1) ml. These met or exceeded values of previously reported systems.
Lee
Kihak
K
Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Fox
Peter T
PT
Lancaster
Jack L
JL
Jerabek
Paul A
PA
D000792:Angiography / Q000295:instrumentation* / Q000379:methods; D001158:Arteries; D006801:Humans; D049268:Positron-Emission Tomography / Q000295:instrumentation* / Q000379:methods; D011849:Radioactive Tracers
D011849:Radioactive Tracers