Development of human striatal anlagen after transplantation in a patient with Huntington's disease.
Replacement of damaged neuronal population by fetal tissue transplantation represents a potential treatment for neurodegenerative diseases. Consistent success has been achieved with fetal striatal transplantation in Huntington's disease animal models and patients. We report the neo-generation of metabolically active tissue with striatum-like imaging features after transplantation of striatal primordia in a patient with Huntington's disease. This study represents the first "in vivo" demonstration that a human striatal anlagen, transplanted into the adult human brain, is able to progress in its development and to generate a new anatomical structure in the host, without evidence of neoplasia or teratoma.
Gallina
Pasquale
P
Department of Neurosurgery, University of Florence, Florence, Italy.
Paganini
Marco
M
Lombardini
Letizia
L
Saccardi
Riccardo
R
Marini
Mirca
M
De Cristofaro
Maria Teresa
MT
Pinzani
Pamela
P
Salvianti
Francesca
F
Crescioli
Clara
C
Di Rita
Andrea
A
Bucciantini
Sandra
S
Mechi
Claudia
C
Sarchielli
Erica
E
Moretti
Marco
M
Piacentini
Silvia
S
Gritti
Gaetano
G
Bosi
Alberto
A
Sorbi
Sandro
S
Orlandini
Giovanni
G
Vannelli
Gabriella B
GB
Di Lorenzo
Nicola
N
D000328:Adult; D016380:Brain Tissue Transplantation / Q000379:methods*; D002478:Cells, Cultured; D003342:Corpus Striatum / Q000196:embryology* / Q000378:metabolism / Q000637:transplantation*; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D016332:Fetal Tissue Transplantation / Q000379:methods*; D007839:Functional Laterality / Q000502:physiology; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D009473:Neuronal Plasticity / Q000502:physiology; D038361:Neuronavigation; D049268:Positron-Emission Tomography; D013238:Stereotaxic Techniques; D016896:Treatment Outcome