title: Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism.
abstract: Adenosine A(2A) antagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A(2A) antagonist) to reverse the locomotor suppression and tremor produced by dopamine antagonists in rats. MSX-3 reversed haloperidol-induced suppression of locomotion, and reduced the tremulous jaw movements induced by haloperidol, pimozide, and reserpine. Infusions of MSX-3 into the nucleus accumbens core increased locomotion in haloperidol-treated rats, but there were no effects of infusions into the accumbens shell or ventrolateral neostriatum. In contrast, MSX-3 injected into the ventrolateral neostriatum reduced pimozide-induced tremulous jaw movements. Dopamine/adenosine interactions in different striatal subregions are involved in distinct aspects of motor function.
authors.affiliation: Behavioral Neuroscience Division, Department of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA. john.salamone@uconn.edu
authors.forename: John D
authors.initials: JD
authors.lastname: Salamone
authors.forename: Keita
authors.initials: K
authors.lastname: Ishiwari
authors.forename: Adrienne J
authors.initials: AJ
authors.lastname: Betz
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Farrar
authors.forename: Susana M
authors.initials: SM
authors.lastname: Mingote
authors.forename: Laura
authors.initials: L
authors.lastname: Font
authors.forename: Jörg
authors.initials: J
authors.lastname: Hockemeyer
authors.forename: Christa E
authors.initials: CE
authors.lastname: Müller
authors.forename: Mercè
authors.initials: M
authors.lastname: Correa
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D008124:Locomotion / Q000502:physiology*; D010300:Parkinson Disease / Q000209:etiology*; D014202:Tremor / Q000150:complications / Q000378:metabolism / Q000503:physiopathology
chemical_list: D000241:Adenosine; D004298:Dopamine