title: Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters.
abstract: OBJECTIVE
  To investigate the relationship between the expression of P120 and the clinicopathologic parameters in intrahepatic cholangiocarcinoma (ICC).
  
  
  METHODS
  An immunohistochemical study of E-cadherin and P120 catenin was performed on 42 specimens of ICC with a Dako Envision kit.
  
  
  RESULTS
  The expression of E-cadherin and P120 was reduced in 27 cases (64.3%) and 31 cases (73.8%), respectively. Both E-cadherin and P120 expressions were significantly correlated with the tumor histological grade (chi2 = 9.333, P = 009 and chi2 = 11.71, P = 0.003), TNM stage (chi2= 8.627, P = 0.035 and chi2 = 13.123, P = 0.004), intrahepatic metastasis (chi2= 7.292, P = 0.007 and chi2 = 4.657, P = 0.041, respectively) and patients' survival (chi2= 6.351, P = 0.002 and chi2 = 4.023, P = 0.000, respectively). In addition, the expression of P120 was in concordance with that of E-cadherin (chi2 = 13.797, P = 0.000), indicating that the expression of P120 may be dependent on that of E-cadherin. Finally, only P120 expression was found to be an independent prognostic factor in Cox regression model (r = 0.088, P = 0.049).
  
  
  CONCLUSIONS
  Down-regulated expression of E-cadherin and P120 occurs frequently in ICC and contributes to the progression and development of tumor. Both of them may be valuable biologic markers for predicting tumor invasion, metastasis and patients' survival, but only P120 is an independent prognostic factor for ICC.
authors.affiliation: Department of Ultrasonic Intervention, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhai
authors.forename: He-Xin
authors.initials: HX
authors.lastname: Yan
authors.forename: Shu-Qin
authors.initials: SQ
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Meng-Chao
authors.initials: MC
authors.lastname: Wu
authors.forename: Hong-Yang
authors.initials: HY
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D001653:Bile Ducts, Intrahepatic / Q000737:chemistry* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis*; D015820:Cadherins / Q000032:analysis; D051177:Catenins; D015815:Cell Adhesion Molecules / Q000032:analysis*; D018281:Cholangiocarcinoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010750:Phosphoproteins / Q000032:analysis*; D011379:Prognosis; D016016:Proportional Hazards Models; D000095002:Delta Catenin
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D051177:Catenins; D015815:Cell Adhesion Molecules; D010750:Phosphoproteins; D000095002:Delta Catenin; C000722347:CTNND1 protein, human