HVJ envelope vector, a versatile delivery system: its development, application, and perspectives.
An efficient and minimally invasive vector system is the "bottle neck" of both gene transfer and drug delivery. Numerous viral and non-viral (synthetic) delivery systems have been developed and improved. Hemagglutinating virus of Japan (HVJ, Sendai virus) envelope vector is a novel and unique system which combined the advantages of viral and non-viral vectors with the following features and advantages: (1) safe and easy as a "non-viral" transfection reagent; (2) delivery of various molecules including plasmid DNA, siRNA, protein, antisense oligonucleotide; (3) wide usability from in vitro to in vivo. In this review, the development, application, and perspectives of the HVJ envelope vector will be discussed.
Zhang
Qingxian
Q
Department of Nephrology, Third Hospital, Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang 050051, PR China.
Li
Ying
Y
Shi
Yonghong
Y
Zhang
Yanling
Y
D000818:Animals; D002459:Cell Fusion; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006801:Humans; D007167:Immunotherapy; D007501:Iron / Q000008:administration & dosage; D051379:Mice; D009841:Oligonucleotides / Q000008:administration & dosage / Q000235:genetics; D010957:Plasmids; D018111:Pneumovirus; D011506:Proteins / Q000008:administration & dosage / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics
D009841:Oligonucleotides; D011506:Proteins; D034741:RNA, Small Interfering; D007501:Iron