Synthesis of tunable bisphosphine ligands and their application in asymmetric hydrogenation of quinolines.
A series of tunable axial chiral bisphosphine ligands have been synthesized from (S)-MeO-Biphep. The Ir complex of the MeO-PEG-supported ligand (S)-4k has been successfully applied in asymmetric hydrogenation of quinolines with up to 92% ee. The catalyst system is air-stable and recyclable.
Wang
Xiao-Bing
XB
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, People's Republic of China.
Zhou
Yong-Gui
YG
D002384:Catalysis; D006865:Hydrogenation; D008024:Ligands; D008745:Methylation; D015394:Molecular Structure; D010720:Phosphines / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry*; D013237:Stereoisomerism
D008024:Ligands; D010720:Phosphines; D011804:Quinolines