Local exposure of 849 MHz and 1763 MHz radiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain.
Even though there is no direct evidence to prove the cellular and molecular changes induced by radiofrequency (RF) radiation itself, we cannot completely exclude the possibility of any biological effect of mobile phone frequency radiation. We established a carousel-type exposure chamber for 849 MHz or 1763 MHz of mobile phone RF radiation to expose RF to the heads of C57BL mice. In this chamber, animals were irradiated intermittently at 7.8 W/kg for a maximum of 12 months. During this period, the body weights of 3 groups-sham, 849 MHz RF, and 1763 MHz RF-did not show any differences between groups. The brain tissues were obtained from 3 groups at 6 months and 12 months to examine the differences in histology and cell proliferation between control and RF exposure groups, but we could not find any change upon RF radiation. Likewise, we could not find changes in the expression and distribution of NeuN and GFAP in hippocampus and cerebellum, or in cell death by TUNEL assay in RF exposure groups. From these data, we conclude that the chronic exposure to 849 MHz and 1763 MHz RF radiation at a 7.8 W/kg specific absorption rate (SAR) could not induce cellular alterations such as proliferation, death, and reactive gliosis.
Kim
Tae-Hyung
TH
LCHUN Genomic Medicine Institute, MRC, Seoul National University College of Medicine, Seoul, Korea.
Kim
Tae-Hyoung
TH
Huang
Tai-Qin
TQ
Jang
Ja-June
JJ
Kim
Man Ho
MH
Kim
Hyun-Jeong
HJ
Lee
Jae-Seon
JS
Pack
Jeong Ki
JK
Seo
Jeong-Sun
JS
Park
Woong-Yang
WY
D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D001835:Body Weight / Q000528:radiation effects; D001921:Brain / Q000473:pathology / Q000528:radiation effects*; D040421:Cell Phone; D049109:Cell Proliferation / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005904:Glial Fibrillary Acidic Protein; D005911:Gliosis / Q000209:etiology / Q000473:pathology; D020287:In Situ Nick-End Labeling; D051379:Mice; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis / Q000235:genetics; D011846:Radio Waves / Q000009:adverse effects*
D005904:Glial Fibrillary Acidic Protein; D009419:Nerve Tissue Proteins; D018809:Proliferating Cell Nuclear Antigen; C528900:glial fibrillary astrocytic protein, mouse