Detection of structure-switching in G-quadruplexes using end-stacking ability.
G-quadruplex-forming ODNs containing nonpolar aromatic fluorophore moiety, A(PY) at the dangling ends undergo pi-stacking on surface of G-quadruplex, and the fluorescence change can be used to distinguish the structure-switching between the mixed parallel/antiparallel structure and antiparallel structure.
Seo
Young Jun
YJ
Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Lee
Il Joon
IJ
Kim
Byeang Hyean
BH
D001483:Base Sequence; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D015195:Drug Design; D005456:Fluorescent Dyes / Q000737:chemistry; D054856:G-Quadruplexes; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*; D013696:Temperature
D005456:Fluorescent Dyes; D009841:Oligonucleotides; D004247:DNA