Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects.
BACKGROUND
In the general population, low IGF1 has been associated with higher prevalence of cardiovascular disease and mortality.


OBJECTIVE
To investigate the relationships between IGF1 levels, blood pressure (BP), and glucose tolerance (GT).


METHODS
Four-hundred and four subjects (200 men aged 18-80 years).


METHODS
personal history of pituitary or cardiovascular diseases; previous or current treatments with drugs interfering with BP, GT, or lipids, corticosteroids (>2 weeks), estrogens, or testosterone (>12 weeks); smoking of >15 cigarettes/day and alcohol abuse (>3 glasses of wine/day).


RESULTS
Two hundred and ninety-six had normal BP (73.3%), 86 had mild (21.3%), and 22 had severe (5.4%) hypertension; 322 had normal GT (NGT (79.7%)), 53 had impaired glucose tolerance (IGT (13.1%)), 29 had diabetes mellitus (7.2%). Normotensive subjects had significantly higher IGF1 levels (0.11+/-0.94 SDS) than those with mild (-0.62+/-1.16 SDS, P<0.0001) or severe (-1.01+/-1.07 SDS, P<0.0001) hypertension. IGF1 SDS (t=-3.41, P=0.001) independently predicted systolic and diastolic BP (t=-2.77, P=0.006) values. NGT subjects had significantly higher IGF1 levels (0.13+/-0.90 SDS) than those with IGT (-0.86+/-1.14 SDS, P<0.0001) or diabetes mellitus (-1.31+/-1.13 SDS, P<0.0001). IGF1 SDS independently predicted fasting glucose (t=-3.49, P=0.0005) and homeostatic model assessment (HOMA)-R (t=-2.15, P=0.033) but not insulin (t=-1.92, P=0.055) and HOMA-beta (t=-0.19, P=0.85).


CONCLUSIONS
IGF1 levels in the low normal range are associated with hypertension and diabetes in subjects without pituitary and cardiovascular diseases.
Colao
Annamaria
A
Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S. Pansini 5, 80131 Naples, Italy. colao@unina.it
Di Somma
Carolina
C
Cascella
Teresa
T
Pivonello
Rosario
R
Vitale
Giovanni
G
Grasso
Ludovica F S
LF
Lombardi
Gaetano
G
Savastano
Silvia
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000378:metabolism; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology* / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology / Q000378:metabolism; D006973:Hypertension / Q000453:epidemiology* / Q000378:metabolism*; D015228:Hypertriglyceridemia / Q000453:epidemiology / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
D001786:Blood Glucose; D007334:Insulin-Like Growth Factor I