Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition.
Noncoding RNAs are emerging as central players in gene expression regulation through the targeting of a plethora of mRNAs. Several recent papers report on the regulation of the epithelial phenotype by the miR-200 (200 family of miRNAs) family and a natural antisense transcript, both acting on the E-cadherin repressors zinc-finger E-box-binding homeobox factors ZEB1 and ZEB2. These findings open new avenues for understanding the modulation of the epithelial-to-mesenchymal transition in physiological and pathological situations.
Cano
Amparo
A
Departamento de Bioquímica UAM, Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM Arturo Duperier 4, 28029 Madrid, Spain. acano@iib.uam.es
Nieto
M Angela
MA
D047108:Embryonic Development; D004847:Epithelial Cells; D005786:Gene Expression Regulation; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D059630:Mesenchymal Stem Cells; D035683:MicroRNAs / Q000502:physiology; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D016372:RNA, Antisense / Q000502:physiology*; D012097:Repressor Proteins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D000074165:Zinc Finger E-box Binding Homeobox 2; D000071799:Zinc Finger E-box-Binding Homeobox 1
D018398:Homeodomain Proteins; D035683:MicroRNAs; D016372:RNA, Antisense; D012097:Repressor Proteins; D014157:Transcription Factors; C486307:ZEB1 protein, human; C492363:ZEB2 protein, human; D000074165:Zinc Finger E-box Binding Homeobox 2; D000071799:Zinc Finger E-box-Binding Homeobox 1