title: Immunohistochemical expression of MMPs 1, 7, and 26 in syndrome and nonsyndrome odontogenic keratocysts.
abstract: OBJECTIVE
  The objective of this study was to analyze the expression of matrix metalloproteinases (MMPs) 1, 7, and 26 in odontogenic keratocysts (OKCs) associated with Gorlin syndrome (SOKCs) and nonsyndrome OKCs (NSOKCs).
  
  
  METHODS
  Twenty-one SOKCs and 20 NSOKCs were evaluated for epithelial expression of MMP-1, MMP-7, and MMP-26 and for mesenchymal expression of MMP-1 by immunohistochemistry.
  
  
  RESULTS
  Strong epithelial positivity to MMP-1 was observed in 76% of SOKCs and in 15% of NSOKCs (P < .05). Strong mesenchymal immunoreactivity to MMP-1 was observed in 38% of SOKCs and in 20% of NSOKCs (P > .05). Epithelial immunoreactivity to MMP-7 was strongly positive in 67% of SOKCs and in 40% of NSOKCs (P > .05). For MMP-26, strong positivity was found in 62% of SOKCs, in contrast to 35% of NSOKCs (P > .05).
  
  
  CONCLUSIONS
  MMPs-1, -7 and -26 may play important roles in the biology of OKCs. Furthermore, the presence of these proteases at higher levels in SOKCs may help to explain increased OKC aggressiveness associated with nevoid basal cell carcinoma syndrome.
authors.affiliation: Department of Oral Pathology, School of Dentistry, University of Fortaleza, Ceará, Brazil.
authors.forename: Roberta Barroso
authors.initials: RB
authors.lastname: Cavalcante
authors.forename: Karuza Maria Alves
authors.initials: KM
authors.lastname: Pereira
authors.forename: Cassiano Francisco Weege
authors.initials: CF
authors.lastname: Nonaka
authors.forename: Renato Luiz Maia
authors.initials: RL
authors.lastname: Nogueira
authors.forename: Lélia Batista
authors.initials: LB
authors.lastname: de Souza
mesh_terms: D001478:Basal Cell Nevus Syndrome / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis*; D020783:Matrix Metalloproteinase 7 / Q000096:biosynthesis*; D053505:Matrix Metalloproteinases, Secreted / Q000096:biosynthesis*; D009807:Odontogenic Cysts / Q000201:enzymology*; D013577:Syndrome
chemical_list: D007633:Keratins; C410599:MMP26 protein, human; D053505:Matrix Metalloproteinases, Secreted; D020783:Matrix Metalloproteinase 7; D020781:Matrix Metalloproteinase 1