title: Anthracofibrosis, bronchial stenosis with overlying anthracotic mucosa: possibly a new occupational lung disorder: a series of seven cases From one UK hospital.
abstract: Anthracofibrosis, which was recently defined as bronchial stenosis with overlying anthracotic mucosa, has been infrequently reported in Asia as a complication of tuberculosis (TB). It has not been reported in the United Kingdom or the United States, or, to our knowledge, in non-Asian patients. We have identified seven cases of patients presenting to a single teaching hospital in the northwest of England over a 13-year period. Only one patient had a history of TB, but six of the seven patients had a history of occupational dust exposure, including one patient with pneumoconiosis. It is possible that anthracofibrosis is an exaggerated endobronchial form of the much more common condition of anthracosis in coal miners and other workers who have been exposed to mineral dusts. Our study suggests that this is essentially a benign condition, although it may progress very slowly, leading to gradually progressive bronchial stenosis. The diagnosis is important because most patients have clinical, radiologic, and bronchoscopic changes that are highly suspicious of malignancy.
authors.affiliation: Department of Respiratory Medicine, Salford Royal University Hospital, Salford, UK.
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Wynn
authors.affiliation: Department of Respiratory Medicine, Salford Royal University Hospital, Salford, UK.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Turkington
authors.affiliation: Department of Respiratory Medicine, Salford Royal University Hospital, Salford, UK. Electronic address: ronan.o'driscoll@srft.nhs.uk.
authors.forename: B Ronan
authors.initials: BR
authors.lastname: O'Driscoll
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D055008:Anthracosis / Q000150:complications* / Q000175:diagnosis; D001706:Biopsy; D001982:Bronchial Diseases / Q000175:diagnosis / Q000209:etiology*; D001999:Bronchoscopy; D003251:Constriction, Pathologic; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000175:diagnosis / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D011658:Pulmonary Fibrosis / Q000150:complications* / Q000175:diagnosis; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed