title: Mono- and dicationic short PEG and methylene dioxyalkylglycerols for use in synthetic gene delivery systems.
abstract: A range of monocationic and dicationic dioxyalkylglycerol cytofectins have been synthesised possessing methylene and short n-ethylene glycol spacers. The monocationic compounds were found to be effective in transfections when formulated as lipopolyplexes with peptide and DNA components, in particular with shorter PEG head groups which may have less effect on peptide targeting in the ternary complex.
authors.affiliation: Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Hurley
authors.forename: John B
authors.initials: JB
authors.lastname: Wong
authors.forename: Jimmy
authors.initials: J
authors.lastname: Ho
authors.forename: Michele
authors.initials: M
authors.lastname: Writer
authors.forename: Scott A
authors.initials: SA
authors.lastname: Irvine
authors.forename: M Jayne
authors.initials: MJ
authors.lastname: Lawrence
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Hart
authors.forename: Alethea B
authors.initials: AB
authors.lastname: Tabor
authors.forename: Helen C
authors.initials: HC
authors.lastname: Hailes
mesh_terms: D000595:Amino Acid Sequence; D002460:Cell Line; D004247:DNA / Q000378:metabolism; D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000378:metabolism; D005990:Glycerol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry / Q000378:metabolism*; D014162:Transfection
chemical_list: D010455:Peptides; D011092:Polyethylene Glycols; D004247:DNA; D005990:Glycerol