title: Mortality and causes of death in autism spectrum disorders: an update.
abstract: This study compared mortality among Danish citizens with autism spectrum disorders (ASDs) with that of the general population. A clinical cohort of 341 Danish individuals with variants of ASD, previously followed over the period 1960-93, now on average 43 years of age, were updated with respect to mortality and causes of death. Standardized mortality ratios (SMRs) were calculated for various times after diagnosis. In all, 26 persons with ASD had died, whereas the expected number of deaths was 13.5. Thus the mortality risk among those with ASD was nearly twice that of the general population. The SMR was particularly high in females. The excess mortality risk has remained unchanged since our first study in 1993. Eight of the 26 deaths were associated with epilepsy and four died from epilepsy. Future staff education should focus on better managing of the complex relationships between ASD and physical illness to prevent avoidable deaths.
authors.affiliation: Department of Child and Adolescent Psychiatry, Bispebjerg University Hospital, Copenhagen, Denmark. sem01@bbh.hosp.dk
authors.forename: Svend Erik
authors.initials: SE
authors.lastname: Mouridsen
authors.forename: Henrik
authors.initials: H
authors.lastname: Brønnum-Hansen
authors.forename: Bente
authors.initials: B
authors.lastname: Rich
authors.forename: Torben
authors.initials: T
authors.lastname: Isager
mesh_terms: D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000401:mortality*; D002423:Cause of Death; D002675:Child, Preschool; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D012737:Sex Factors