title: [Serum adiponectin and leptin levels and bone mineral density in 232 men].
abstract: OBJECTIVE
  To investigate whether adiponectin and leptin levels are associated with bone mineral density (BMD) in 232 men (20~80 years old).
  
  
  METHODS
  Serum adiponectin and leptin levels were determined by enzyme-linked immunosorbentassay (ELISA). BMD at various sites was determined using dual energy x-ray absorptiometry (DXA).
  
  
  RESULTS
  Adiponectin was negatively correlated with body fat, while leptin had a positively correlation. Significant negative correlations between adiponectin and BMD were found, which remained significant after adjustment of age and body fat. In the multiple linear stepwise regression analysis, adiponectin but not leptin, was independent predictor of BMD.
  
  
  CONCLUSIONS
  Adiponectin was an independent predictor of BMD in Chinese men. Adiponectin may exert a negative effect on bone mass.
authors.affiliation: Institute of Endocrinology and Metabolism, Second Xiangya Hospital, Central South University, Changsha 410011, China. yanghuzhang123@tom.com
authors.forename: Ling-Feng
authors.initials: LF
authors.lastname: Yang
authors.forename: Hui
authors.initials: H
authors.lastname: Xie
authors.forename: Ling-Qing
authors.initials: LQ
authors.lastname: Yuan
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015519:Bone Density; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis
chemical_list: D052242:Adiponectin; D020738:Leptin