title: Circulating adiponectin levels in patients with atrial fibrillation.
abstract: BACKGROUND
  Atrial fibrillation (AF) characterized by atrial remodeling occurs with obesity-related conditions. Adiponectin, an adipose tissue-derived hormone exerts beneficial effects on ventricular remodeling, so in the present study the potential association between circulating adiponectin levels and atrial remodeling in patients with AF was investigated.
  
  
  RESULTS
  The levels of plasma adiponectin, serum carboxy-terminal telopeptide of collagen type I (CITP), as a collagen type I degradation marker, and serum type III procollagen-N-peptide (PIIINP), as a collagen type III synthesis marker, were measured in 304 consecutive patients (162 paroxysmal AF, 46 persistent AF, 96 paroxysmal supra-ventricular tachycardia [controls]). Plasma adiponectin levels were significantly higher in patients with persistent AF than in those with paroxysmal AF or the control patients (p<0.05). Serum CITP levels, but not serum PIIINP levels, were higher in patients with persistent AF compared with the paroxysmal AF and control patients (p<0.05). In addition, there was a positive correlation between adiponectin levels and CITP levels in patients with persistent AF (r=0.39, p<0.005).
  
  
  CONCLUSIONS
  High plasma adiponectin levels are associated with the presence of persistent AF, which is accompanied by increased CITP levels. Thus, measurement of plasma adiponectin could be useful for assessment of AF.
authors.affiliation: Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shimano
authors.forename: Rei
authors.initials: R
authors.lastname: Shibata
authors.forename: Yukiomi
authors.initials: Y
authors.lastname: Tsuji
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kamiya
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Uchikawa
authors.forename: Shuji
authors.initials: S
authors.lastname: Harata
authors.forename: Masahiro
authors.initials: M
authors.lastname: Muto
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ouchi
authors.forename: Yasuya
authors.initials: Y
authors.lastname: Inden
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood*; D024042:Collagen Type I / Q000097:blood / Q000378:metabolism; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood; D015995:Prevalence; D011347:Procollagen / Q000097:blood; D020257:Ventricular Remodeling / Q000502:physiology
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C041876:procollagen Type III-N-terminal peptide