title: General and efficient copper-catalyzed amidation of saturated C-H bonds using N-halosuccinimides as the oxidants.
abstract: We have developed a general and efficient method for copper-catalyzed amidation of saturated C-H bonds under mild conditions, and the used substrates include benzylic reagents, the N, N-dimethylaniline derivatives, the free carboxamides, and sulfonamides. The protocol uses inexpensive and readily available CuBr/ N-halosuccinimide (NBS or NCS) as the catalyst/oxidant, so it provides practical applications for synthesis of various amides via C-H activation.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Liu
authors.forename: Yongming
authors.initials: Y
authors.lastname: Zhang
authors.forename: Long
authors.initials: L
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Fu
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D001593:Benzyl Compounds / Q000737:chemistry; D001974:Bromosuccinimide / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry*; D013388:Succinimides / Q000737:chemistry*
chemical_list: D000577:Amides; D001593:Benzyl Compounds; D016877:Oxidants; D013388:Succinimides; C015752:N-chlorosuccinimide; D003300:Copper; D001974:Bromosuccinimide