title: Recent advances in annular pathobiology provide insights into rim-lesion mediated intervertebral disc degeneration and potential new approaches to annular repair strategies.
abstract: The objective of this study was to assess the impact of a landmark annular lesion model on our understanding of the etiopathogenesis of IVD degeneration and to appraise current IVD repairative strategies. A number of studies have utilised the Osti sheep model since its development in 1990. The experimental questions posed at that time are covered in this review, as are significant recent advances in annular repair strategies. The ovine model has provided important spatial and temporal insights into the longitudinal development of annular lesions and how they impact on other discal and paradiscal components such as the NP, cartilaginous end plates, zygapophyseal joints and vertebral bone and blood vessels. Important recent advances have been made in biomatrix design for IVD repair and in the oriented and dynamic culture of annular fibrochondrocytes into planar, spatially relevant, annular type structures. The development of hyaluronan hydrogels capable of rapid in situ gelation offer the possibility of supplementation of matrices with cells and other biomimetics and represent a significant advance in biopolymer design. New generation biological glues and self-curing acrylic formulations which may be augmented with slow delivery biomimetics in microcarriers may also find application in the non-surgical repair of annular defects. Despite major advances, significant technical challenges still have to be overcome before the biological repair of this intractable connective tissue becomes a realistic alternative to conventional surgical intervention for the treatment of chronic degenerate IVDs.
authors.affiliation: Raymond Purves Research Laboratory, Institute of Bone & Joint Research, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia. jmelrose@med.usyd.edu.au
authors.forename: James
authors.initials: J
authors.lastname: Melrose
authors.forename: Susan M
authors.initials: SM
authors.lastname: Smith
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Little
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Moore
authors.forename: Barrie
authors.initials: B
authors.lastname: Vernon-Roberts
authors.forename: Robert D
authors.initials: RD
authors.lastname: Fraser
mesh_terms: D000818:Animals; D019902:Chondrocytes / Q000473:pathology; D004195:Disease Models, Animal; D020100:Hydrogels / Q000627:therapeutic use; D007403:Intervertebral Disc / Q000473:pathology / Q000503:physiopathology*; D012756:Sheep; D013122:Spinal Diseases / Q000503:physiopathology* / Q000628:therapy*; D023822:Tissue Engineering / Q000379:methods / Q000639:trends
chemical_list: D020100:Hydrogels