title: [Association of the chromosomal region 2q35 with type 1 diabetes mellitus in the Russian patients from Moscow].
abstract: To map human chromosome 2 region associated with type 1 diabetes mellitus, 89 families with concordant and discordant sib pairs were analyzed. Linkage and association with type 1 diabetes were examined using polymorphic microsatellite markers spanning the region of about 4 Mb. The linkage plot was constructed, and association of the five microsatellite markers within the chromosomal region 2q35 was examined. Polymorphic marker D2S137 (Z' = 3.225, p(c) = 0.0048) demonstrated maximum linkage and association with type 1 diabetes.
authors.forename: A
authors.initials: A
authors.lastname: Chernysheva
authors.forename: N M
authors.initials: NM
authors.lastname: Tsitlidze
authors.forename: K V
authors.initials: KV
authors.lastname: Savost'ianov
authors.forename: L I
authors.initials: LI
authors.lastname: Zil'berman
authors.forename: T L
authors.initials: TL
authors.lastname: Kuraeva
authors.forename: V A
authors.initials: VA
authors.lastname: Peterkova
authors.forename: I I
authors.initials: II
authors.lastname: Dedov
authors.forename: V V
authors.initials: VV
authors.lastname: Nosikov
mesh_terms: D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005190:Family; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D009031:Moscow; D011110:Polymorphism, Genetic