title: Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors.
abstract: We report here a comparative study of the anti-hepatitis C virus (HCV) activities of selected (i) nucleoside polymerase, (ii) nonnucleoside polymerase, (iii) alpha,gamma-diketo acid polymerase, (iv) NS3 protease, and (v) helicase inhibitors, as well as (vi) cyclophilin binding molecules and (vii) alpha 2b interferon in four different HCV genotype 1b replicon systems.
authors.affiliation: Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: Paeshuyse
authors.forename: Inge
authors.initials: I
authors.lastname: Vliegen
authors.forename: Lotte
authors.initials: L
authors.lastname: Coelmont
authors.forename: Pieter
authors.initials: P
authors.lastname: Leyssen
authors.forename: Oriana
authors.initials: O
authors.lastname: Tabarrini
authors.forename: Piet
authors.initials: P
authors.lastname: Herdewijn
authors.forename: Harald
authors.initials: H
authors.lastname: Mittendorfer
authors.forename: Johnny
authors.initials: J
authors.lastname: Easmon
authors.forename: Violetta
authors.initials: V
authors.lastname: Cecchetti
authors.forename: Ralf
authors.initials: R
authors.lastname: Bartenschlager
authors.forename: Gerhard
authors.initials: G
authors.lastname: Puerstinger
authors.forename: Johan
authors.initials: J
authors.lastname: Neyts
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004265:DNA Helicases / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D016174:Hepacivirus / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D011480:Protease Inhibitors / Q000494:pharmacology*; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors; D012093:Replicon / Q000187:drug effects / Q000235:genetics; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D011480:Protease Inhibitors; D012324:RNA-Dependent RNA Polymerase; D004265:DNA Helicases