Intracranial aneurysms in sickle cell patients: report of 2 cases and review of the literature.
BACKGROUND
The sickle cell disease has different neurologic complications, including cerebral aneurysms. This disease may lead to endothelial damage, which favors the development of cerebral aneurysms. Only a few cases demonstrated by cerebral angiography or surgery have been reported in the English literature referring to cerebral aneurysms in sickle cell patients.


METHODS
We report 2 patients with sickle cell disease whose cerebral aneurysms were successfully treated by open surgery.


CONCLUSIONS
Sickle cell patients have a high occurrence of multiple aneurysms, and a high prevalence of posterior circulation aneurysms. This must be interpreted with caution, and further studies are needed to confirm this association.
Brandão
Rafael Augusto Castro Santiago
RA
Department of Neurosurgery, Santa Casa Hospital, Faculty of Medical Science of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. rafabrand@gmail.com
de Carvalho
Gervásio Teles C
GT
Reis
Baltazar Leão
BL
Bahia
Enderson
E
de Souza
Atos Alves
AA
D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D002533:Cerebral Angiography; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000209:etiology* / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome