title: A case of granulomatous rosacea successfully treated with pimecrolimus cream.
abstract: A 43-year-old male attended with lesions on his face that had been present for 3 months. On dermatological examination, multiple papules and pustules were seen on the forehead, nose, bilateral cheeks and lower eyelids. The patient used systemic clindamycin and doxycycline and topical benzoyl peroxide therapies, but the lesions did not regress. Routine laboratory tests were normal. Histopathological examination of the lesions confirmed the diagnosis of granulomatous rosacea. Pimecrolimus cream 1% was applied to the lesions. The regression of lesions began in the first month and complete improvement was observed at the end of the fourth month of therapy. Rosacea is a chronic, inflammatory skin disorder characterized by remissions and relapses. Although it is known that the disease is a treatable disorder, it may be resistant to standard therapies and there is a need for new therapy alternatives in some patients. We present a case of granulomatous rosacea successfully treated with pimecrolimus cream and believe that pimecrolimus may be a good alternative for the treatment of granulomatous rosacea.
authors.affiliation: 2nd Dermatology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Ulker
authors.initials: U
authors.lastname: Gül
authors.forename: Müzeyyen
authors.initials: M
authors.lastname: Gönül
authors.forename: Arzu
authors.initials: A
authors.lastname: Kiliç
authors.forename: Oğuzhan
authors.initials: O
authors.lastname: Koçak
authors.forename: Erkan
authors.initials: E
authors.lastname: Aslan
authors.forename: Gülüşan
authors.initials: G
authors.lastname: Ergül
authors.forename: Sezer
authors.initials: S
authors.lastname: Kulaçoğlu
mesh_terms: D000328:Adult; D003879:Dermatologic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012393:Rosacea / Q000188:drug therapy* / Q000473:pathology; D016559:Tacrolimus / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D003879:Dermatologic Agents; C117268:pimecrolimus; D016559:Tacrolimus