title: Effect of bacterial filter on measurement of interrupter resistance in preschool and school-aged children.
abstract: BACKGROUND
  The interrupter technique is increasingly used in preschool children to assess airway resistance (Rint). Use of a bacterial filter is essential for prevention of cross-infection in a clinical setting. It is not known how large an effect this extra resistance and compliance exert upon interrupter measurements, especially on obstructive airways and in smaller children. We aim to determine the contribution of the filter to Rint, in a sample of children attending lung function testing at an asthma clinic.
  
  
  METHODS
  Interrupter measurements were performed according to ATS/ERS guidelines during quiet normal breathing at an expiratory flow trigger of 200 ml s(-1), with the child seated upright with cheeks supported and wearing a nose clip. A minimum of 10 interrupter measurements was made with and without a bacterial filter. Spirometric and plethysmographic tests were also performed.
  
  
  RESULTS
  A small but significant difference (0.12 (95% CI 0.06-0.17) kPa s L(-1), P = 0.0002) with 2x SD of 0.34 kPa s L(-1) was observed between Rint with and without filter in 39 children, with a large spread. This difference was not dependent on Rint magnitude, age or height, nor on lung function parameters (effective resistance, forced expiratory volume in 1 sec, and maximal expiratory flow at 50% of expired vital capacity).
  
  
  CONCLUSIONS
  A bacterial filter causes a small difference but is not clinically significant, with a wide spread comparable to the variability of the technique and recommended cut-offs for assessing repeatability and bronchodilation. Age, height or severity of obstruction need not be corrected for in general.
authors.affiliation: Paediatric Respiratory Medicine, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland. cindy.thamrin@insel.ch
authors.forename: C
authors.initials: C
authors.lastname: Thamrin
authors.forename: U
authors.initials: U
authors.lastname: Frey
mesh_terms: D000403:Airway Resistance / Q000502:physiology*; D001249:Asthma / Q000175:diagnosis*; D001424:Bacterial Infections / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008851:Micropore Filters; D010993:Plethysmography, Whole Body / Q000295:instrumentation* / Q000379:methods; D013147:Spirometry / Q000295:instrumentation* / Q000379:methods