title: [Circulating levels of oxidative stress and adipocytokines in obese subjects].
abstract: OBJECTIVE
  To investigate the relationship between adipocytokines levels and oxidative stress in obese males.
  
  
  METHODS
  The levels of 8-iso-prostaglandinF2alpha(8-iso-PGF2alpha), superoxide dismutase (SOD), malondialdehyde (MDA), adiponectin, leptin, restistin, TNF-receptors 1(TNF-R1), Interleukin-1beta(IL-1beta) and Interleukin-6(IL-6) were measured in obese men and normal controls.
  
  
  RESULTS
  The levels of 8-iso-PGF(2alpha), MDA, leptin, TNF-R1, IL-1beta and IL-6 was significantly higher than that normal controls (P<0.05, P<0.01). The levels of adiponectin and the activity of SOD decreased significantly in obese men.There was no significant difference in the restistin between obese men and normal controls. There was significantly positive correlation between 8-iso-PGF(2alpha) and body mass index (BMI) (r=0.54, P<0.05) in obese. A significantly negative correlation was found between 8-iso-PGF(2alpha) and adiponectin (r=-0.56, P<0.05) in obese subjects. The levels of leptin was negative correlated with body fat content(%)(r=-0.53, P<0.05) in obese subjects. A significant negative correlation was observed between the levels of adiponectin and LDL(r=-0.54, P<0.05), IL-6 (r=-0.41, P<0.05). In a multiple regression analysis model, the levels of adiponectin and IL-6 were the main determinants of the oxidative stress in obese men.
  
  
  CONCLUSIONS
  Changed concentration of adipocytokines was found in obese men. There are significantly correlation with between oxidative stress and adipocytokines.
authors.affiliation: Department of Endocrinology, Xiamen University Affiliated Zhongshan Hospital, Xiamen 361004, China.
authors.forename: Xing-Ping
authors.initials: XP
authors.lastname: Shen
authors.forename: Sen-Biao
authors.initials: SB
authors.lastname: Zou
authors.forename: Hao-Jie
authors.initials: HJ
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D001786:Blood Glucose; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology*; D012044:Regression Analysis; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D054392:Adipokines; D052242:Adiponectin; D001786:Blood Glucose; D053583:Interleukin-1beta; D015850:Interleukin-6; D020738:Leptin; C075750:8-epi-prostaglandin F2alpha; D008315:Malondialdehyde; D015237:Dinoprost; D013482:Superoxide Dismutase