Langerhans cell dogma: another round of rejections.
Mice that are deficient in epidermal Langerhans cells allow the functions of these cells in vivo to be rigorously assessed. Experiments that have been carried out with these animals have yielded surprising results, leading to major changes in existing paradigms. In this issue, Obhrai and coworkers explore the involvement of Langerhans cells in skin graft rejection and describe fascinating results.
Udey
Mark C
MC
Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. udey@helix.nih.gov
Rosenberg
Amy S
AS
D000818:Animals; D004167:Diphtheria Toxin / Q000494:pharmacology; D005260:Female; D006084:Graft Rejection / Q000276:immunology* / Q000473:pathology; D007801:Langerhans Cells / Q000187:drug effects / Q000276:immunology* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D023421:Models, Animal; D011042:Poisons / Q000494:pharmacology; D016038:Skin Transplantation / Q000276:immunology* / Q000473:pathology
D004167:Diphtheria Toxin; D011042:Poisons