Clinical efficacy of proton magnetic resonance spectroscopy (1H-MRS) in the diagnosis of localized prostate cancer.
BACKGROUND
The objective of this study was to evaluate the efficacy of proton magnetic resonance spectroscopy (1H-MRS) in the detection of prostate cancer.


METHODS
The experimental group consisted of 20 patients with localized prostate cancer who underwent radical prostatectomy. The sensitivity, positive predictive value and accuracy of the detection of prostate cancer in the 12 sections of the peripheral zone were calculated for prostate biopsy alone, 1H-MRS alone and the combination of these methods, respectively.


RESULTS
The sensitivity, the positive predictive value, and the accuracy of the preoperative diagnosis of prostate cancer were 43.7%, 68.9% and 54.6%, respectively, with prostate biopsy alone; 60.6%, 87.8% and 71.4% with 1H-MRS alone; and 88.7%, 88.7% and 87.4% with the combination of biopsy and 1H-MRS, respectively. Combined use of biopsy and 1H-MRS significantly improved the sensitivity, positive predictive value and accuracy of the diagnosis.


CONCLUSIONS
1H-MRS together with biopsy might improve the diagnostic accuracy in prostate cancer.
Saito
Keisuke
K
Department of Urology, Teikyo University School of Medicine, Tokyo, Japan.
Kaminaga
Tatsuro
T
Muto
Satoru
S
Ide
Hisamitsu
H
Nishio
Koujiro
K
Kamiyama
Yutaka
Y
Okada
Hiroshi
H
Terado
Yuichi
Y
Furui
Shigeru
S
Horie
Shigeo
S
D000368:Aged; D001706:Biopsy; D002794:Choline / Q000378:metabolism; D019343:Citric Acid / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D011522:Protons
D011522:Protons; D019343:Citric Acid; D003401:Creatine; D002794:Choline