title: Long-term management of generalized pustular psoriasis with infliximab: case series.
abstract: BACKGROUND
  Infliximab, a tumor necrosis factor alpha antagonist, has recently been shown to be successful for the short-term treatment of generalized pustular psoriasis (GPP) in multiple case reports.
  
  
  OBJECTIVE
  The goal of this case series was to assess the efficacy of the longer-term management of GPP with infliximab.
  
  
  METHODS
  Three patients with severe GPP were followed to assess the efficacy of long-term treatment with infliximab.
  
  
  RESULTS
  Infliximab therapy was more efficacious with infusion every 6 to 8 weeks in combination with methotrexate.
  
  
  CONCLUSIONS
  Infliximab may be efficacious for some patients for the long-term management of GPP. Maintaining a strict infliximab infusion schedule and concomitant methotrexate therapy may decrease infusion reactions and increase efficacy.
authors.affiliation: Department of Dermatology, Murdough Family Center for Psoriasis, University Hospitals of Cleveland, Case Medical Center, Cleveland, OH, USA.
authors.forename: Shannon B
authors.initials: SB
authors.lastname: Routhouska
authors.forename: Pranav B
authors.initials: PB
authors.lastname: Sheth
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Korman
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000069285:Infliximab; D007262:Infusions, Intravenous; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy*
chemical_list: D000911:Antibodies, Monoclonal; D003879:Dermatologic Agents; D000069285:Infliximab; D008727:Methotrexate