title: Medulloblastoma in the first year of life: A report of five cases.
abstract: Five infants with cerebellar medulloblastoma, who all presented within the first year of life, are presented. The initial characteristic presenting symptoms included vomiting and macrocrania, frequently followed by a delay in normal development. No patients showed any signs or symptoms of cerebellar dysfunction. One infant, who was initially diagnosed as having a congenital hydrocephalus, died 4 months after undergoing a cerebrospinal fluid shunt operation, while the remaining four patients all underwent direct surgery for their tumors and three also received an additional course of postoperative radiation therapy. Of these four patients, three died within 4 years after diagnosis, with a mean survival period of 2.7 years, whereas one is still alive after a follow-up period of more than 20 years. However, the patient does suffer from both physical and intellectual handicaps. The clinical and histological features of infantile medulloblastomas are reviewed while the therapeutic problems associated with these tumors are also discussed.
authors.affiliation: Department of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nishio
authors.forename: T
authors.initials: T
authors.lastname: Morioka
authors.forename: M
authors.initials: M
authors.lastname: Fukui