title: Subchronic, reproductive, and developmental toxicity of a fluorotelomer-based urethane polymeric product.
abstract: A commercial fluorotelomer-based urethane polymeric dispersion, consisting of polymer, surfactant, and water, was evaluated in subchronic, reproduction, and developmental toxicity studies. The dispersion was administered daily by gavage to rats at dosages of 0, 50, 250, or 1000 mg polymer/kg/day or with 70 mg/kg/day of the sulfonate surfactant. Dose levels of 0, 50, 250, or 1000 mg polymer/kg/day were also used for the reproductive and developmental studies. Nasal olfactory epithelial degeneration and necrosis occurred in all dose groups in the 90-day study. Nasal adhesions were observed only in rats administered surfactant alone. Liver-enzyme alterations at 250 and 1000 mg/kg were considered to be potentially adverse effects. The subchronic no-observed-adverse-effects level (NOAEL) was 50 mg/kg. For the reproduction study, rats were dosed for 10 weeks prior to cohabitation and throughout mating, gestation, and lactation. There were no effects on reproductive function in males or females at any dosage. Thyroid weight was decreased in the 250 and 1000 mg/kg day F(1) groups unaccompanied by microscopic effects. In the developmental toxicity study, female rats were dosed from gestation days 6-20; there was no test-substance-related embryolethality, nor was there any dose-related increase in either fetal malformations. Fetal weight was minimally decreased at 1000 mg/kg/day in the presence of slight maternal toxicity; the NOAEL for developmental parameters was 250 mg/kg/day. The polymeric product was not a specific developmental or reproductive toxin.
authors.affiliation: DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA.
authors.forename: Judith C
authors.initials: JC
authors.lastname: Stadler
authors.forename: Donald A
authors.initials: DA
authors.lastname: Delker
authors.forename: Linda A
authors.initials: LA
authors.lastname: Malley
authors.forename: Steven R
authors.initials: SR
authors.lastname: Frame
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Everds
authors.forename: Eve
authors.initials: E
authors.lastname: Mylchreest
authors.forename: Susan M
authors.initials: SM
authors.lastname: Munley
authors.forename: Scott E
authors.initials: SE
authors.lastname: Loveless
authors.forename: Robert C
authors.initials: RC
authors.lastname: Buck
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005333:Fetus / Q000187:drug effects; D005466:Fluorocarbons / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009297:Nasal Mucosa / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D011108:Polymers / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000633:toxicity*; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism; D000267:Tissue Adhesions / Q000139:chemically induced; D018675:Toxicity Tests; D014520:Urethane / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D005466:Fluorocarbons; D011108:Polymers; D013501:Surface-Active Agents; D014520:Urethane