Dioxygenase- and monooxygenase-catalysed synthesis of cis-dihydrodiols, catechols, epoxides and other oxygenated products.
Oxidoreductases are an emerging class of biotechnologically relevant enzymes due to their regio- and stereo-specificity. The selective oxygenation of aromatic compounds by oxidoreductases has received much attention and a wide range of reactions have been documented using these enzymes from various microbial sources. This review gives an overview of various dioxygenase, monooxygenase and oxidase enzymes that have been manipulated for the synthesis of products such as cis-dihydrodiols, catechols, epoxides and other oxygenated products. The use of protein engineering and its advancement in the synthesis of recombinant enzymes is also discussed.
Nolan
Louise C
LC
School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
O'Connor
Kevin E
KE
D002384:Catalysis; D002396:Catechols / Q000737:chemistry / Q000378:metabolism*; D049308:Dioxygenases / Q000378:metabolism*; D004852:Epoxy Compounds / Q000737:chemistry / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D008956:Models, Chemical; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000378:metabolism*
D002396:Catechols; D004852:Epoxy Compounds; D009281:Naphthalenes; D006899:Mixed Function Oxygenases; D049308:Dioxygenases