title: [New dammarane type triterpene with cyclization at the side chain from oxidative alkaline-degradation products of PQS].
abstract: To study the oxidative alkaline-degradation products of PQS (Panax quinquefolium saponin), two compounds were isolated from the crude product of oxidative alkaline-degradation by silica gel column chromatography, Sephadex LH-20 column chromatography and recrystallized methods. On the basis of spectroscopic analysis, their structures were established as (12R, 20S, 24R)-20, 24; 12, 24-diepoxy-24-deisopropyl-dammarane-3beta-ol (1) and (20S, 24R)-20, 24-epoxydammarane-3beta3, 12beta, 25-triol (2). Compounds 1 and 2, dammarane type triterpene with cyclization at the side chain, were obtained for the first time from alkaline-degradation products of total ginsenosides of Panax quinquefolium L., compound 1 is a new compound.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Huang
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Xian
authors.initials: X
authors.lastname: Li
authors.forename: Lu-Sha
authors.initials: LS
authors.lastname: Gao
authors.forename: Da-Li
authors.initials: DL
authors.lastname: Meng
mesh_terms: D003500:Cyclization; D010084:Oxidation-Reduction; D005894:Panax / Q000737:chemistry*; D012502:Sapogenins / Q000737:chemistry; D012503:Saponins / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry*; D000097669:Dammaranes
chemical_list: D012502:Sapogenins; D012503:Saponins; D013256:Steroids; D014315:Triterpenes; D000097669:Dammaranes; C079995:Panax quinquefolium saponin