title: Robotic laparoscopic radical prostatectomy for biopsy Gleason 8 to 10: prediction of favorable pathologic outcome with preoperative parameters.
abstract: OBJECTIVE
  We sought to evaluate the pathologic results and postoperative outcomes for men undergoing robot-assisted laparoscopic radical prostatectomy (RLRP) for biopsy Gleason score (GS) 8 to 10 disease. Stratification of these patients according to preoperative variables was also performed in an attempt to predict organ-confined cancer.
  
  
  METHODS
  A prospective RLRP database identified all patients with preoperative biopsy GS 8 to 10. Variables, including prostate-specific antigen (PSA), percent positive biopsy cores (%PBC), maximal percentage of cancer in biopsy core (%MCB), clinical stage, pathologic stage, pathologic GS, surgical margins status, lymph node status, time to biochemical recurrence, and recurrence rate, were evaluated. Preoperative variables were treated as continuous and categorical using PSA, %PBC and %MCB cutoffs of 10 ng/mL, 50%, and 30%, respectively.
  
  
  RESULTS
  Between February 2003 and September 2007, a total of 1225 RLRPs were performed at the University of Chicago Medical Center. Seventy-two (5.9%) patients had preoperative biopsy GS 8 to 10. Two patients received neoadjuvant hormonal therapy and were excluded. Among 70 patients evaluated, 33 (47%) had organconfined (pT(2)N0) disease. Forty (60.6%) patients had pathologic downgrading to GS <or=7. Overall positive surgical margin (PSM) rate was found to be 24.2%. pT(2)- and pT(3)-PSM rate was 6% and 42.3%, respectively. In multivariate logistic regression analysis, PSA <or=10 ng/mL (P = 0.04) and %MCB <or=30% (P = 0.001) were found to be statistically significant predictors of pT(2)N0 disease.
  
  
  CONCLUSIONS
  Preoperative biopsy GS 8 to 10 predicts a significant likelihood of finding non-organ-confined prostate cancer on the final pathology report. Preoperative PSA <or=10 ng/mL and %MCB <or=30% may be used to predict favorable pathologic outcome for these patients during surgical counseling.
authors.affiliation: Section of Urology, Department of Surgery, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA. sergeyshikanov@gmail.com
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Shikanov
authors.forename: Alan
authors.initials: A
authors.lastname: Thong
authors.forename: Ofer N
authors.initials: ON
authors.lastname: Gofrit
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Zagaja
authors.forename: Gary D
authors.initials: GD
authors.lastname: Steinberg
authors.forename: Arieh L
authors.initials: AL
authors.lastname: Shalhav
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Zorn
mesh_terms: D001706:Biopsy; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011300:Preoperative Care; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D012371:Robotics / Q000379:methods*; D016896:Treatment Outcome