title: Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill.
abstract: Schisandrin is the main active ingredient isolated from the fruit of Schisandra chinensis Baill. Recent studies have demonstrated that schisandrin exhibits anti-oxidative effects in vivo. In the present study, the effect of schisandrin on plasma nitrite concentration in lipopolysaccharide (LPS)-treated mice was evaluated. It also significantly inhibited carrageenan-induced paw edema and acetic acid-induced vascular permeability in mice. Furthermore, schisandrin had a protective effect on lipopolysaccharide (LPS)-induced sepsis. In vitro, our results are the first that show that the anti-inflammatory properties of schisandrin result from the inhibition of nitric oxide (NO) production, prostaglandin E(2) (PGE(2)) release, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, which in turn results from the inhibition of nuclear factor-kappaB (NF-kappaB), c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) activities in a RAW 264.7 macrophage cell line.
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-747, South Korea.
authors.forename: Lian Yu
authors.initials: LY
authors.lastname: Guo
authors.forename: Tran Manh
authors.initials: TM
authors.lastname: Hung
authors.forename: Ki Hwan
authors.initials: KH
authors.lastname: Bae
authors.forename: Eun Myoung
authors.initials: EM
authors.lastname: Shin
authors.forename: Hong Yu
authors.initials: HY
authors.lastname: Zhou
authors.forename: Yoo Na
authors.initials: YN
authors.lastname: Hong
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
authors.forename: Hyun Pyo
authors.initials: HP
authors.lastname: Kim
authors.forename: Yeong Shik
authors.initials: YS
authors.lastname: Kim
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D002460:Cell Line; D034242:Cyclooctanes / Q000302:isolation & purification / Q000494:pharmacology*; D051546:Cyclooxygenase 2 / Q000187:drug effects / Q000378:metabolism; D015232:Dinoprostone / Q000037:antagonists & inhibitors / Q000378:metabolism; D005638:Fruit; D005786:Gene Expression Regulation / Q000187:drug effects; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects / Q000378:metabolism; D009573:Nitrites / Q000097:blood; D011083:Polycyclic Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D032141:Schisandra / Q000737:chemistry*; D018805:Sepsis / Q000517:prevention & control
chemical_list: D000893:Anti-Inflammatory Agents; D034242:Cyclooctanes; D017705:Lignans; D008070:Lipopolysaccharides; D009573:Nitrites; D011083:Polycyclic Compounds; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2; C011105:schizandrin; D015232:Dinoprostone