title: Respiratory treatment of amyotrophic lateral sclerosis.
abstract: Amyotrophic lateral sclerosis is a progressive neurodegenerative disease with no known cure. The major cause of mortality and major morbidities is related to the effects of the disease on the muscles of the respiratory system (ie, the inspiratory, expiratory, and upper airway muscles). Dyspnea, swallowing difficulties, sialorrhea, and impaired cough are all symptoms that can be palliated through pharmacologic and nonpharmacologic means. Noninvasive positive pressure ventilation, in particular, is a technique that not only relieves dyspnea but may also extend the lives of patients who have this disease. It should be offered to all patients who have amyotrophic lateral sclerosis with a forced vital capacity of less than 50 percent.
authors.affiliation: University of Washington Medical Center, Pulmonary and Critical Care Medicine, 1959 NE Pacific Street, Box 356522, Seattle, WA 98195-6522, USA. benditt@u.washington.edu
authors.forename: Joshua O
authors.initials: JO
authors.lastname: Benditt
authors.forename: Louis
authors.initials: L
authors.lastname: Boitano
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000534:rehabilitation*; D006801:Humans; D012138:Respiratory Therapy / Q000379:methods*; D016896:Treatment Outcome