title: Discoid lupus erythematosus (DLE) in a Spitz dog.
abstract: A 3-year-old, female Spitz, was presented due to lack of response to therapies with a 6-month history of skin lesions characterized by diffuse erythema and scaling on the dorsal trunk. Physical examination revealed the dog was active and healthy. Skin culture isolated no fungus. Histological examination of skin biopsy specimens revealed interface dermatitis with hydropic degeneration of the basal layers, predominant plasmacytic perivascular accumulation in the dermis, and intensive plasma cell-rich interface mural folliculitis. Moderate CD3-positive lymphocytes infiltrated the superficial dermis. This report may provide unique information of canine discoid lupus erythematosus in an unusual breed with atypical cutaneous lesions.
authors.affiliation: Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea.
authors.forename: Moon-Jung
authors.initials: MJ
authors.lastname: Goo
authors.forename: Jin-Kyu
authors.initials: JK
authors.lastname: Park
authors.forename: Il-Hwa
authors.initials: IH
authors.lastname: Hong
authors.forename: Hai-Jie
authors.initials: HJ
authors.lastname: Yang
authors.forename: Dong-Wei
authors.initials: DW
authors.lastname: Yuan
authors.forename: Mi-Ran
authors.initials: MR
authors.lastname: Ki
authors.forename: Jung-Youn
authors.initials: JY
authors.lastname: Han
authors.forename: Ae-Ri
authors.initials: AR
authors.lastname: Ji
authors.forename: Tae-Hwan
authors.initials: TH
authors.lastname: Kim
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Williams
authors.forename: Kyu-Shik
authors.initials: KS
authors.lastname: Jeong
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry; D008179:Lupus Erythematosus, Discoid / Q000473:pathology / Q000662:veterinary*; D013045:Species Specificity