title: [Feasibility and anti-tumor activity of postoperative adjuvant chemotherapy with gemcitabine for resected pancreatic cancer].
abstract: The feasibility and anti-tumor activity of gemcitabine (GEM) as postoperative adjuvant chemotherapy were evaluated retrospectively. Between September 1998 and June 2007, patients with resected invasive pancreatic cancer (stage III, IVa, IVb) were given adjuvant chemotherapy with GEM (GEM group, n=10) or did not receive chemotherapy (n=11). Started the administration of GEM 38.5 days after surgery, and the mean duration was 15.4 months. Grade 3 or 4 adverse event was not observed in the GEM group. There was a significant difference in overall survival between the GEM group and the no-chemotherapy group (p=0.037), but there was no significant difference in disease-free survival between the two groups. Adjuvant chemotherapy with GEM was feasible and showed a benefit in patients with invasive pancreatic cancer.
authors.affiliation: Dept. of Surgery, Mitoyo General Hospital.
authors.forename: Tetsunobu
authors.initials: T
authors.lastname: Udaka
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Konishi
authors.forename: Naohisa
authors.initials: N
authors.lastname: Waki
authors.forename: Makio
authors.initials: M
authors.lastname: Hayama
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kubo
authors.forename: Osanori
authors.initials: O
authors.lastname: Sogabe
authors.forename: Hiroya
authors.initials: H
authors.lastname: Maeda
authors.forename: Minoru
authors.initials: M
authors.lastname: Mizuta
authors.forename: Kazutoyo
authors.initials: K
authors.lastname: Shirakawa
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000601:surgery; D015996:Survival Rate; D000093542:Gemcitabine
chemical_list: D000970:Antineoplastic Agents; D003841:Deoxycytidine; D000093542:Gemcitabine