title: Slower onset of vasodilating action of brain natriuretic peptide (BNP) compared to atrial natriuretic peptide (ANP) in human forearm resistant vessels.
abstract: OBJECTIVE
  To investigate possible differences in the time course of vasodilating effects of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in humans.
  
  
  METHODS
  We measured forearm blood flow (FBF) by strain gauge plethymography and cyclic GMP spillover during and after intra-arterial infusions of BNP and ANP at 16.2 pmol/min for 30 min in healthy subjects.
  
  
  RESULTS
  The steady-state responses of FBF and cyclic GMP to the infusion were achieved approximately 20 min after commencement of the infusion of BNP, but within 5 min for ANP, with similar magnitudes of maximum responses. These parameters more slowly returned to the baseline value after withdrawal of the BNP infusion than after the ANP infusion.
  
  
  CONCLUSIONS
  The onset and disappearance of the guanylate cyclase-stimulating and vasodilating effects of BNP were significantly slower than those of ANP. This differing mode of vasodilator action may be relevant to the therapeutic use of natriuretic peptides.
authors.affiliation: Department of Clinical Pharmacology & Therapeutics, University of the Ryukyus, Graduate School of Medicine, Nishihara, Okinawa, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Minami
authors.forename: Takanori
authors.initials: T
authors.lastname: Yasu
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Tagawa
authors.forename: Ken
authors.initials: K
authors.lastname: Yamakawa
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Ueda
mesh_terms: D000293:Adolescent; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000494:pharmacology*; D006152:Cyclic GMP / Q000097:blood*; D005542:Forearm / Q000098:blood supply; D006162:Guanylate Cyclase / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*; D055815:Young Adult
chemical_list: D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor; D006162:Guanylate Cyclase; D006152:Cyclic GMP