title: Maintaining the silence: reflections on long-term RNAi.
abstract: Since the demonstration of RNA interference (RNAi) in mammalian cells, considerable research and financial effort has gone towards implementing RNAi as a viable therapeutic platform. RNAi is, without doubt, the most promising strategy for the treatment of human genetic disorders. Because many of the targets proposed for RNAi therapy require chronic treatment, researchers agree that the emphasis must now be placed on the safe and long-term application of RNAi drugs to reap the benefits at last.
authors.affiliation: Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium.
authors.forename: Koen
authors.initials: K
authors.lastname: Raemdonck
authors.forename: Roosmarijn E
authors.initials: RE
authors.lastname: Vandenbroucke
authors.forename: Joseph
authors.initials: J
authors.lastname: Demeester
authors.forename: Niek N
authors.initials: NN
authors.lastname: Sanders
authors.forename: Stefaan C
authors.initials: SC
authors.lastname: De Smedt
mesh_terms: D000818:Animals; D020868:Gene Silencing; D006801:Humans; D007700:Kinetics; D015233:Models, Statistical; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D034741:RNA, Small Interfering