title: Hepatoprotective activity of Vitex negundo leaf extract against anti-tubercular drugs induced hepatotoxicity.
abstract: Hepatoprotective (HP) activity of Vitex negundo (VN) leaf ethanolic extract was investigated against hepatotoxicity (HT) produced by administering a combination of three anti-tubercular drugs isoniazid (INH)-7.5 mg/kg, rifampin (RMP)-10 mg/kg and pyrazinamide (PZA)-35 mg/kg for 35 35 days by oral route in rats. V. negundo leaf ethanolic extract was administered in three graded doses of 100, 250 and 500 mg/kg orally, 45 min prior to anti-tubercular challenge for 35 days. HP effect of V. negundo leaf ethanolic extract was evident in the doses of 250 and 500 mg/kg as there was a significant decrease in TB, AST, ALT and ALP levels in comparison to control. Histology of the liver section of the animals treated with the V. negundo leaf ethanolic extract in the doses of 250 and 500 mg/kg further confirms the HP activity.
authors.affiliation: Post-Graduate Department of Pharmacology and Therapeutics, Govt. Medical College Jammu (J and K), 180001 India. dr_vishaltandon@yahoo.com
authors.forename: Vishal R
authors.initials: VR
authors.lastname: Tandon
authors.forename: V
authors.initials: V
authors.lastname: Khajuria
authors.forename: B
authors.initials: B
authors.lastname: Kapoor
authors.forename: D
authors.initials: D
authors.lastname: Kour
authors.forename: S
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves; D020011:Protective Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D020950:Vitex / Q000737:chemistry
chemical_list: D000995:Antitubercular Agents; D010936:Plant Extracts; D020011:Protective Agents