[Effects of HuDan Granules on lipid metabolism and antioxidant activity of mice with hyperlipidemia].
OBJECTIVE
To study the effects of HuDan Granules on lipid metabolism and antioxidant activity of mice with hyperlipidemia.


METHODS
Seventy-eight mice were divided into six groups randomly: the normal control group, hyperlipemia group, HuDan Granules high, middle, low dose group and the Simvastatin group. Besides the normal control group, all the mice in the other groups were fed with lipid emulsion for 4 weeks. The Chinese medicine groups were treated with HuDan Granules at the dose of 12,6,3 g/kg, the normal control group and hyperlipemia group were treated with normal sodium, the Simvastatin group were treated with Simvastatin. After 4 weeks, the TC, TG, HDL-C, LDL-C, SOD, GSH-Px and LPO in serum were measured.


RESULTS
HuDan Granules groups could significantly decrease the serum TC, TG, HDL-C in the experimental hyperlipidemia mice, and markedly increase the level of serum HDL-C. Mean level of serum LPO in the experimental groups treated by HuDan Granules at different dosages were much lower than that in hyperlipidemia group (P<0.05), but higher than the Simvastatin group (P<0.05). And the SOD and GSH-Px activities of serum in the group of HuDan Granules were much higher than those in hyperlipidemia group and the Simvastatin group (P<0.05).


CONCLUSIONS
HuDan Granules can regulate lipid metabolism, enhance the antioxidation and reduce the lipid peroxidation in mice with hyperlipidemia.
Zheng
Meng-Wei
MW
Department of Pharmacy, First People's Hospital of Haizhu, Guangzhou 510220, China.
Zheng
Lin
L
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D050356:Lipid Metabolism / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D008517:Phytotherapy; D011897:Random Allocation; D019821:Simvastatin / Q000494:pharmacology / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000097:blood; D014280:Triglycerides / Q000097:blood
D000975:Antioxidants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004365:Drugs, Chinese Herbal; C539159:HuDan; D000960:Hypolipidemic Agents; D014280:Triglycerides; D019821:Simvastatin; D013482:Superoxide Dismutase