title: [Seroprevalence of Mycoplasma pneumoniae in children aged under 12 years].
abstract: BACKGROUND
  Although Mycoplasma pneumoniae is usually assumed as an infection mainly prevalent in school aged children and adolescents, there is evidence supporting that it may occur at younger ages. This could be related to social conditions, like crowding and day care center/school attendance more frequently and at younger ages than two decades ago. We estimated the prevalence of antibodies anti- Mycoplasma pneumoniae in children aged under 12 years. We also evaluated its association with age, day care center/school attendance, crowding or other children in the household.
  
  
  METHODS
  This cross-sectional study included children aged under 12 years that required blood sampling for surgery. Those with acute infections, chronic diseases or known immunological disorders were excluded. In all cases predictors were recorded, and IgG anti-Mycoplasma pneumoniae determined by enzimoimmunoassay. Association between predictors and seropositivity was evaluated by logistic regression.
  
  
  RESULTS
  We included 355 children, aged 4.8 +/- 3.1 years. 57.6% attended to day care center/school, crowding was present in 27.3% and 70.1% had other children in the household. IgG antibodies anti-Mycoplasma pneumoniae were present in 12.4%. Seropositives were older than seronegatives (7.1 +/- 3.15 years vs. 4.4 +/- 3.06 years, p < 0.0001). After controlling by confounders, age remains as an independent predictor of seropositivity (OR: 1.19, CI 95%: 1.043-1.362).
  
  
  CONCLUSIONS
  Seroprevalence of Mycoplasma pneumoniae IgG antibodies in children aged under 12 years was 12.4%. Age is an independent predictor of seropositivity.
authors.affiliation: División Inmunología, Departamento Consultorios Externos, Hospital de Niños Dr. Pedro de Elizalde, Buenos Aires.
authors.forename: Andrea
authors.initials: A
authors.lastname: Lezcano
authors.forename: Jeannete
authors.initials: J
authors.lastname: Balbaryski
authors.forename: Fernando
authors.initials: F
authors.lastname: Torres
authors.forename: Adrián
authors.initials: A
authors.lastname: Cutri
authors.forename: Alejandra
authors.initials: A
authors.lastname: Coarasa
authors.forename: María F
authors.initials: MF
authors.lastname: Ossorio
authors.forename: Fernando
authors.initials: F
authors.lastname: Ferrero
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009177:Mycoplasma pneumoniae / Q000276:immunology*; D011019:Pneumonia, Mycoplasma / Q000097:blood* / Q000453:epidemiology*; D016036:Seroepidemiologic Studies
chemical_list: D000907:Antibodies, Bacterial