title: The characterization of selected drugs with infrared laser desorption/tunable synchrotron vacuum ultraviolet photoionization mass spectrometry.
abstract: Some selected drugs including captopril, fudosteine and racecadotril have been analyzed by infrared (IR) laser desorption/tunable synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometry (PIMS). The molecular ions of captopril and racecadotril are exclusively observed without any fragments at near threshold single-photon ionization (SPI). However, fudosteine easily forms fragments even at a photon energy near the ionization threshold, indicating the instability of its molecular ion. For these drugs, a number of fragments are yielded with the increase of photon energy. The structures of such fragments proposed by IR LD/VUV PIMS are supported by electron ionization time-of-flight mass spectrometry (EI-TOFMS) results. Fragmentation pathways are discussed in detail.
authors.affiliation: National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui 230029, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Pan
authors.forename: Hao
authors.initials: H
authors.lastname: Yin
authors.forename: Taichang
authors.initials: T
authors.lastname: Zhang
authors.forename: Huijun
authors.initials: H
authors.lastname: Guo
authors.forename: Liusi
authors.initials: L
authors.lastname: Sheng
authors.forename: Fei
authors.initials: F
authors.lastname: Qi
mesh_terms: D000959:Antihypertensive Agents / Q000737:chemistry; D002216:Captopril / Q000737:chemistry; D003553:Cystine / Q000031:analogs & derivatives / Q000737:chemistry; D007259:Infrared Rays; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010777:Photochemistry; D011480:Protease Inhibitors / Q000737:chemistry; D015203:Reproducibility of Results; D021241:Spectrometry, Mass, Electrospray Ionization; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*; D017356:Synchrotrons; D015244:Thiorphan / Q000031:analogs & derivatives / Q000737:chemistry; D014466:Ultraviolet Rays; D014618:Vacuum
chemical_list: D000959:Antihypertensive Agents; D004364:Pharmaceutical Preparations; D011480:Protease Inhibitors; D003553:Cystine; C049331:racecadotril; D002216:Captopril; D015244:Thiorphan; C113797:fudosteine