Copper-mediated N-cyclopropylation of azoles, amides, and sulfonamides by cyclopropylboronic acid.
Reaction of azoles, amides, and sulfonamides in dichloroethane with readily available cyclopropylboronic acid in the presence of copper acetate and sodium carbonate afforded the N-cyclopropyl derivatives in good to excellent yields.
Bénard
Sébastien
S
Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France.
Neuville
Luc
L
Zhu
Jieping
J
D000085:Acetates / Q000737:chemistry; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D001393:Azoles / Q000138:chemical synthesis / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D003521:Cyclopropanes / Q000138:chemical synthesis / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry*
D000085:Acetates; D000577:Amides; D001393:Azoles; D001897:Boronic Acids; D003521:Cyclopropanes; D013449:Sulfonamides; D003300:Copper