Computational tools for the analysis of rearrangements in mammalian genomes.
The chromosomes of mammalian genomes exhibit reasonably high levels of similarity that can be used to study small-scale sequence variations. A different approach is to study the evolutionary history of rearrangements in entire genomes based on the analysis of gene or segment orders. We describe three computational tools (GRIMM-Synteny, GRIMM, and MGR) that can be used separately or in succession to contrast different organisms at the genome-level to exploit large-scale rearrangements as a phylogenetic character.
Tesler
Glenn
G
Department of Mathematics, University of California-San Diego, La Jolla, CA.
Bourque
Guillaume
G
D000818:Animals; D019295:Computational Biology / Q000379:methods*; D015321:Gene Rearrangement; D016678:Genome / Q000235:genetics*; D008322:Mammals / Q000235:genetics*; D012984:Software; D026801:Synteny / Q000235:genetics