Anti-inflammatory activity of indanyltetrazole derivatives.
A number of indanyl tetrazolederivatives namely 5-(6'-chloroindan-1'-yl)tetrazole (CIT), 5-(6'-bromoindan-1'-yl)tetrazole (BIT), 5-(6'-chloroindan-1'-yl)methyltetrazole (CIMT), 5-(6'-bromoindan-1'-yl)methyl-tetrazole (BIMT) were evaluated for the anti-inflammatory activity in carragennan induced rat paw edema in Swiss albino Wister rats for 24-hour period at the dose of 100 mg/kg of body weight by intraperitoneal route where phenylbutazone (PBZ) was used as the standard. All of these compounds exhibited inhibition on rat paw edema with peak actions observed following 3 hours after administration. Moreover, compounds CIMT and BIMT were further evaluated at dose of 50 mg/kg of body weight. Among the compounds, CIMT showed higher activity than others and was very close to standard phenylbutazone.
Bepary
Sukumar
S
Department of Pharmacy, East West University, Mohakhali, Dhaka, Bangladesh.
Das
Biplab K
BK
Bachar
Sitesh C
SC
Kundu
Joydev K
JK
Shamsur Rouf
Abu Shara
AS
Datta
Bidyut K
BK
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002351:Carrageenan; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D007189:Indans / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013777:Tetrazoles / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D007189:Indans; D013777:Tetrazoles; D002351:Carrageenan; D010653:Phenylbutazone