Randomized controlled trial comparing gastrectomy plus chemotherapy with chemotherapy alone in advanced gastric cancer with a single non-curable factor: Japan Clinical Oncology Group Study JCOG 0705 and Korea Gastric Cancer Association Study KGCA01.
A randomized controlled trial has started in both Japan and Korea to evaluate the role of gastrectomy in the management of incurable advanced gastric cancer (AGC). Patients with AGC diagnosed as having a single non-curable factor are randomized to gastrectomy plus chemotherapy or chemotherapy alone. Surgeons at 33 specialized centers in Japan and at 15 high-volume hospitals in Korea will recruit 330 patients. Primary end-point is overall survival, and secondary end-points are progression-free survival and adverse events associated with either gastrectomy or chemotherapy.
Fujitani
Kazumasa
K
Department of Surgery, National Osaka Medical Center, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan. fujitani@onh.go.jp
Yang
Han-Kwang
HK
Kurokawa
Yukinori
Y
Park
Do Joong
DJ
Tsujinaka
Toshimasa
T
Park
Byung-Joo
BJ
Fukuda
Haruhiko
H
Noh
Sung Hoon
SH
Boku
Narikazu
N
Bang
Yung-Jue
YJ
Sasako
Mitsuru
M
Lee
Jong-Inn
JI
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002985:Clinical Protocols; D005743:Gastrectomy; D006801:Humans; D007564:Japan; D007723:Korea; D008875:Middle Aged; D018579:Patient Selection; D012107:Research Design; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*