Clearing the way for unpaused polymerases.
Heat shock loci in the polytene chromosomes of the fruit fly Drosophila undergo a characteristic change in appearance that coincides with the onset of gene expression. Petesch and Lis (2008) now show that nucleosomes are lost across the entire Hsp70 locus in an initial wave that precedes transcription by RNA polymerase II.
Weake
Vikki M
VM
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Workman
Jerry L
JL
D000818:Animals; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism*; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D018869:Heat-Shock Response; D009707:Nucleosomes / Q000378:metabolism*; D012319:RNA Polymerase II / Q000378:metabolism*; D014158:Transcription, Genetic
D029721:Drosophila Proteins; D018840:HSP70 Heat-Shock Proteins; D009707:Nucleosomes; D012319:RNA Polymerase II