title: Synthesis and antimicrobial studies of novel 1-benzhydryl-piperazine sulfonamide and carboxamide derivatives.
abstract: A series of novel substituted 1-benzhydryl-piperazine sulfonamide 8(a-f) and benzamides 9(a-h) were synthesized and their antimicrobial activities evaluated in vitro by paper disc diffusion and micro dilution method against standard strains of Gram-positive (Staphylococcus aureus ATCC 25953, Staphylococcus epidermis 25212, Bacillus cereus 11778, Bacillus substilis 6051) and Gram-negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 2853, Proteus vulgaris ATCC 2853 and Salmonella typhi ATCC 9484) bacteria. Among the synthesized new compounds 8d, 8e, 9c, 9e, 9f and 9 h showed potent antimicrobial activities compared to the standard drug streptomycin.
authors.affiliation: Department of Studies in Chemistry, University of Mysore, Mysore, India.
authors.forename: C S Ananda
authors.initials: CS
authors.lastname: Kumar
authors.forename: K
authors.initials: K
authors.lastname: Vinaya
authors.forename: J Narendra Sharath
authors.initials: JN
authors.lastname: Chandra
authors.forename: N R
authors.initials: NR
authors.lastname: Thimmegowda
authors.forename: S B Benaka
authors.initials: SB
authors.lastname: Prasad
authors.forename: C T
authors.initials: CT
authors.lastname: Sadashiva
authors.forename: K S
authors.initials: KS
authors.lastname: Rangappa
mesh_terms: D000577:Amides / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D010879:Piperazines; D013449:Sulfonamides