1,5-Benzothiazepine, a versatile pharmacophore: a review.
1,5-Benzothiazepine and 1,5-benzodiazipine are the two main seven-membered heterocyclic ring systems reported for their cardiac and psychotherapeutic activities. Successful introduction of diltiazem and clentiazem for angina pectoris, hypertension, arrhythmias and other related cardiac disorders proved potential of 1,5-benzothiazepine moiety. Subsequently 1,5-benzodiazepines were highlighted as important biologically active scaffolds. Also, discovery of thiazesim and quetiapine fumarate as psychotropic agents attracted much attention worldwide. The current review article focuses on pharmacological profile associated with 1,5-benzodiazepines. This article mainly covers structural modifications done for various targets along with the brief description of the targets.
Bariwal
Jitender B
JB
Department of Chemistry, Saurashtra University, Rajkot 360 005, Gujarat, India.
Upadhyay
Kuldip D
KD
Manvar
Atul T
AT
Trivedi
Jalpa C
JC
Singh
Jyoti S
JS
Jain
Kishor S
KS
Shah
Anamik K
AK
D000818:Animals; D001569:Benzodiazepines / Q000737:chemistry* / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000737:chemistry; D002147:Calmodulin / Q000037:antagonists & inhibitors / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects
D002121:Calcium Channel Blockers; D002147:Calmodulin; D001569:Benzodiazepines