Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells.
Pregabalin and gabapentin are lipophilic amino acid derivatives of gamma-amino butyric acid that show anticonvulsant and analgesic activity against neuropathic pain. In this study, we investigated their actions on substance P-induced NF-kappaB activation in human neuroblastoma and rat glioma cells. Pregabalin and gabapentin decreased substance P-induced NF-kappaB activation in these cells. These drugs also inhibited NF-kappaB activation in rat spinal dorsal root ganglia cells pre-treated in vitro with substance P. These results suggest a previously undefined role of pregabalin and gabapentin in the regulation of inflammation-related intracellular signaling in both neuronal and glial cells.
Park
Seyeon
S
Dongduk Women's University, Department of Applied Chemistry, Seoul, Korea. sypark21@dongduk.ac.kr
Ahn
Eun Sook
ES
Han
Dong Woo
DW
Lee
Jong Hwa
JH
Min
Kyung Tae
KT
Kim
Hyunkyung
H
Hong
Yong-Woo
YW
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D045744:Cell Line, Tumor; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D000077206:Gabapentin; D005727:Ganglia, Spinal / Q000473:pathology; D005910:Glioma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009447:Neuroblastoma / Q000378:metabolism / Q000473:pathology*; D000069583:Pregabalin; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D013373:Substance P / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D016328:NF-kappa B; D013373:Substance P; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin