title: Triterpenoid saponins from Androsace umbellata and their anti-proliferative activities in human hepatoma cells.
abstract: Two new triterpenoid saponins, along with five known ones, were isolated from the EtOH extract of the whole plants of Androsace umbellata. The structures of the new triterpenoid saponins were identified as 3- O-[ beta- D-xylopyranosyl-(1-->2)- beta- D-glucopyranosyl-(1-->4)-[ beta- D-glucopyranosyl-(1-->2)]- alpha- L-arabinopyranosyl]-3 beta-hydroxy-13 beta,28-epoxy-16-oxo-oleanan-30-al ( 1) and 3- O- beta- D-xylopyranosyl-(1-->2)- beta- D-glucopyranosyl-(1-->4)- alpha- L-arabinopyranosyl-3 beta-hydroxy-13 beta,28-epoxy-16-oxo-oleanan-30-al ( 2) on the basis of their spectral and chemical properties. All these compounds showed significant cytotoxic activities in human hepatoma cells.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P R China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Dongmei
authors.initials: D
authors.lastname: Zhang
authors.forename: Wencai
authors.initials: W
authors.lastname: Ye
authors.forename: Zhiqi
authors.initials: Z
authors.lastname: Yin
authors.forename: Kwok-Pui
authors.initials: KP
authors.lastname: Fung
authors.forename: Shouxue
authors.initials: S
authors.lastname: Zhao
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Yao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D015394:Molecular Structure; D029623:Primulaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes