Predictors of mortality from community-onset bloodstream infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae.
In a cohort study of 36 patients with community-onset extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli or Klebsiella pneumoniae bloodstream infections, we found that predictors of mortality were community-onset infection with ESBL-producing K. pneumoniae pathogens (P = .02) and failure to receive an initial empirical regimen that included either beta-lactam and beta-lactamase-inhibitors or a carbapenem (P = .04).
Apisarnthanarak
Anucha
A
Division of Infectious Diseases, Faculty of Medicine, Thammasat University Hospital, Pratumthani, Thailand. anapisarn@yahoo.com
Kiratisin
Pattarachai
P
Mundy
Linda M
LM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000382:microbiology / Q000401:mortality; D015780:Carbapenems / Q000627:therapeutic use; D017714:Community-Acquired Infections / Q000382:microbiology / Q000401:mortality; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D004927:Escherichia coli Infections / Q000382:microbiology* / Q000401:mortality; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology* / Q000401:mortality; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000096:biosynthesis*
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases