[Ceramides and adhesive molecules in stable ischaemic heart disease].
The aim of the study was assessment of plasma level of ceramides and adhesive molecules in patients with stable ischaemic heart disease (IHD). Ischaemic heart disease was verified by coronary angiography as a 1.2 or 3 vessels disease. The study based on 35 patients (11F, 24 M,aged 40-74 yrs). The control group consisted of 16 healthy persons (5F, 11M, aged 43-66 yrs). Fasting plasma was drown to asses levels of ceramides, the soluble forms of E-selectin and intercellular adhesive molecule-1 (ICAM-1) and total cholesterol, chol-HDL, chol-LDL and triglicerides. Decreased concentrations of ceramides with mono- and polyunsaturated fatty acids were observed in patients with stable IHD. In 3 vessels disease the total level of ceramides was higher than in 1 vessel disease (p < 0.05). The plasma concentration of sE-selectin, ssICAM-1 were elevated in patients compared to control group (p < 0.02 and p < 0.05, respectively). The plasma levels of sICAM-1 were significantly higher in 3 vessels disease than in 1 vessel disease (p < 0.01). Ceramides concentration with saturated fatty acids correlated with adhesive molecules (p < 0.05). A negative correlation was observed between sICAM-1 concentration and ceramides with palmitoleic acid or docosahexaenoic acid (p < 0.05).
Modrzejewski
Wojciech
W
Klinika Kardiologii, Akademii Medycznej Białystok. wojmod@wp.pl
Knapp
Malgorzata
M
Dobrzyn
Agnieszka
A
Musial
Wlodzimierz J
WJ
Górski
Jan
J
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002518:Ceramides / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D002518:Ceramides; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019040:E-Selectin; D014280:Triglycerides; D018799:Intercellular Adhesion Molecule-1; D002784:Cholesterol