title: The role of extracorporeal blood purification therapies in the prevention of radiocontrast-induced nephropathy.
abstract: Radiocontrast-induced nephropathy (RCIN) is a common and potentially serious complication following diagnostic and therapeutic cardiology procedures using radiocontrast media. The first and most important step in reducing the likelihood of RCIN is to identify patients at risk, by medical history and measurement of serum creatinine concentration to allow calculation of estimated glomerular filtration rate (GFR). Extracorporeal blood purification effectively removes radiocontrast media from the circulation. Periprocedural extracorporeal blood purification (hemodialysis or continuous renal replacement therapy) does not reduce the incidence of RCIN compared with standard medical therapy, and cannot be recommended at this time. The potential benefit of continuous venovenous hemofiltration published by a single center should be confirmed with further studies before it can be recommended or disregarded, and higher doses of continuous renal replacement therapy may also merit further investigation.
authors.affiliation: Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, International Renal Research Institute Vicenza (IRRIV), Vicenza - Italy. dinnacruzmd@yahoo.com
authors.forename: D N
authors.initials: DN
authors.lastname: Cruz
authors.forename: M A
authors.initials: MA
authors.lastname: Perazella
authors.forename: C
authors.initials: C
authors.lastname: Ronco
mesh_terms: D003287:Contrast Media / Q000009:adverse effects*; D006440:Hemofiltration; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis
chemical_list: D003287:Contrast Media