Effect of water-soluble coenzyme Q10 on noise-induced hearing loss in guinea pigs.
CONCLUSIONS
The results of this study indicate that coenzyme Q10 reduces cochlear oxidative stress induced by acoustic overstimulation.


OBJECTIVE
We investigated the effects of coenzyme Q10 on noise-induced hearing loss in guinea pigs.


METHODS
Animals received water-soluble coenzyme Q10 intraperitoneally 2 h before noise exposure. Seven days after noise exposure (130 dB sound pressure level for 3 h), the auditory brainstem response (ABR) threshold shift and cochlear hair cell damage were assessed.


RESULTS
We observed that the ABR threshold shift was significantly less in the coenzyme Q10 group than in the vehicle control group. In addition, the percentage of missing outer hair cells was lower in the coenzyme Q10 group than in the control group. Moreover, 2 days after administration of coenzyme Q10, increased antioxidative activity in the cochlea, as measured by analysis of hydroxy radical scavenging activity by electron spin resonance was observed.
Hirose
Yoshinobu
Y
Department of Otolaryngology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
Sugahara
Kazuma
K
Mikuriya
Takefumi
T
Hashimoto
Makoto
M
Shimogori
Hiroaki
H
Yamashita
Hiroshi
H
D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001309:Auditory Threshold; D004578:Electron Spin Resonance Spectroscopy; D016057:Evoked Potentials, Auditory, Brain Stem; D016166:Free Radical Scavengers / Q000494:pharmacology; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000166:cytology; D006317:Hearing Loss, Noise-Induced / Q000517:prevention & control*; D017665:Hydroxyl Radical / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
D000447:Aldehydes; D000975:Antioxidants; D016166:Free Radical Scavengers; D014451:Ubiquinone; D017665:Hydroxyl Radical; C024989:coenzyme Q10; C027576:4-hydroxy-2-nonenal