Hypolipidemic effect in cholesterol-fed rats of a soluble fiber-rich product obtained from cocoa husks.
A new soluble cocoa fiber product (SCFP), obtained after enzymatic treatment of cocoa husks, was characterized and its potential health effects studied in an animal model of dietary-induced hypercholesterolemia. The SCFP was rich in soluble dietary fiber (DF) and antioxidant polyphenols. Consumption of a cholesterol-rich diet containing the SCFP as a source of DF resulted in lower food intake and body weight gain in comparison with control groups consuming cholesterol-free or cholesterol-rich diets with cellulose as DF. The cholesterol-rich diet caused remarkable hypercholesterolemia. However, the SCFP diminished the negative impact of the cholesterol-rich diet, buffering the decrease of high density lipoprotein-cholesterol, and the increase of total and low density lipoprotein-cholesterol levels, and lipid peroxidation (malondialdehyde levels) induced by the fatty diet. The SCFP also decreased triglyceride levels to values lower than those in the group fed the cholesterol-free diet. These results put forward the potential application of the SCFP as a dietary supplement or functional food ingredient.
Ramos
Sonia
S
Department of Metabolism and Nutrition, Instituto del Frio, Spanish Council for Scientific Research (CSIC), C/ Jose Antonio Novais 10, 28040 Madrid, Spain.
Moulay
Leila
L
Granado-Serrano
Ana Belén
AB
Vilanova
Olga
O
Muguerza
Begoña
B
Goya
Luis
L
Bravo
Laura
L
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000032:analysis; D002099:Cacao / Q000737:chemistry*; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004043:Dietary Fiber / Q000008:administration & dosage* / Q000032:analysis; D005419:Flavonoids / Q000008:administration & dosage / Q000032:analysis; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D012995:Solubility
D000975:Antioxidants; D002791:Cholesterol, Dietary; D004043:Dietary Fiber; D005419:Flavonoids; D000960:Hypolipidemic Agents; D008055:Lipids; D008315:Malondialdehyde