The SP-AP compound wave in patients with auditory neuropathy.
CONCLUSIONS
This study suggests that the asynchronization of the cochlear afferent pathway may be one mechanism of the etiopathogenesis of auditory neuropathy.


OBJECTIVE
To investigate the characteristics of the SP-AP compound wave and its generating mechanism in patients with auditory neuropathy.


METHODS
The electrocochleogram (ECochG) was recorded with external ear canal electrode in patients with auditory neuropathy and normal subjects. The peak-latency, amplitude, and time course of the SP-AP compound wave were measured by using an 'assessor-blind' study. The discrepancy between the two groups was evaluated by statistical analysis.


RESULTS
The SP-AP compound waveform in the auditory neuropathy patient group was unrepresentative. The transient character of the SP-AP compound wave was more atypical than that for the normal cases. SP dominance (-SP/AP>0.4) appeared. The amplitude of both AP and SP was lower than that of the control group. The width of the SP-AP compound wave at one-third of its peak was greater than that of the control group.
Lu
Yunyun
Y
Department of Otolaryngology-Head and Neck Surgery, Chao Yang Hospital, Beijing, PR, China.
Zhang
Qian
Q
Wen
Yuting
Y
Ji
Fei
F
Chen
Aiting
A
Xi
Xing
X
Li
Xingqi
X
D000293:Adolescent; D000328:Adult; D001300:Audiometry, Evoked Response; D001309:Auditory Threshold / Q000502:physiology; D016022:Case-Control Studies; D002648:Child; D003056:Cochlear Nerve / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000502:physiology; D000160:Vestibulocochlear Nerve Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D055815:Young Adult