title: Botulinum toxin type A as an adjuvant treatment modality for extensive Hailey-Hailey disease.
abstract: BACKGROUND
  Extensive Hailey-Hailey disease is often resistant to conventional topical and systemic therapies. The systemic and ablative therapies have many side effects and/or high recurrence rates. Therefore, an alternative safe and effective treatment is needed.
  
  
  OBJECTIVE
  To assess the effectiveness of botulinum toxin type A in the treatment of extensive Hailey-Hailey disease.
  
  
  METHODS
  The cases of six patients with extensive Hailey-Hailey disease resistant to multiple therapeutic regimens were studied and described. Adjuvant therapy with botulinum toxin type A/Dysport was started in all six cases.
  
  
  RESULTS
  Marked improvement of the lesions was achieved with few side effects in all patients.
  
  
  CONCLUSIONS
  Botulinum toxin type A is a safe and effective adjuvant treatment for extensive Hailey-Hailey disease.
authors.affiliation: Catharina Hospital Eindhoven, Eindhoven, The Netherlands. w.koeyers@erasmusmc.nl
authors.forename: Wendy Jane
authors.initials: WJ
authors.lastname: Koeyers
authors.forename: Simone
authors.initials: S
authors.lastname: Van Der Geer
authors.forename: Gertruud
authors.initials: G
authors.lastname: Krekels
mesh_terms: D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D016506:Pemphigus, Benign Familial / Q000188:drug therapy* / Q000473:pathology
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A