title: Efficacy of a square presentation of V-RG vaccine baits in red fox, domestic dog and raccoon dog.
abstract: Oral vaccination programmes conducted in rabies infected countries from Eastern Europe and Eurasia should not be restricted to foxes but should target other major rabies vectors such as dogs and raccoon dogs as well. The objective of this experimental trial was to assess the protection induced by the vaccine by challenging these different species, which had been previously vaccinated intramuscularly with the square V-RG baits (produced in the US). Different parameters were evaluated such as attractiveness of the baits and induction of neutralising antibodies as an indicator for immunogenicity and protection after rabies challenge. The acceptability of the square bait was satisfactory in dogs, foxes and raccoon dogs, confirming previous laboratory and field studies conducted with the rectangular baits. Only one vaccinated dog out of nine seroconverted after vaccination and among them one dog died of rabies. Eight of ten vaccinated foxes seroconverted after vaccination and survived the rabies challenge. All vaccinated raccoon dogs seroconverted after challenge and all survived the challenge. These trials demonstrated that the square presentation of the V-RG vaccine was attractive, immunogenic and efficacious.
authors.affiliation: WHO Collaborating Centre for Research and Management in Zoonoses Control, OIE Reference Laboratory for Rabies, AFSSA, Malzeville, France. f.cliquet@afssa.fr
authors.forename: F
authors.initials: F
authors.lastname: Cliquet
authors.forename: A L
authors.initials: AL
authors.lastname: Guiot
authors.forename: C
authors.initials: C
authors.lastname: Schumacher
authors.forename: J
authors.initials: J
authors.lastname: Maki
authors.forename: N
authors.initials: N
authors.lastname: Cael
authors.forename: J
authors.initials: J
authors.lastname: Barrat
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D005589:Foxes / Q000821:virology*; D007273:Injections, Intramuscular / Q000662:veterinary; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology; D046031:Raccoon Dogs / Q000821:virology*; D011897:Random Allocation; D013045:Species Specificity
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines