title: [Peridural application of ropivacaine and clonidine for pain therapy after prostatectomy].
abstract: OBJECTIVE
  The aim of this study was to find out if ropivacaine with clonidine can be successfully used after radical retropubic prostatectomy.
  
  
  METHODS
  A total of 86 patients were randomized into two groups each consisting of 43 patients. Patients in group 1 received epidural bupivacaine/morphine/clonidine and those in group 2 ropivacaine and clonidine. If necessary analgesic, antiemetic or antihistamine drugs were administered. Pain on a visual analogue scale (VAS), motoric and sensoric disturbances, sedation, itching, nausea and vomiting, hypotension, need of antihistamines, naloxon, antiemetics, ephedrine, and analgesics were also documented.
  
  
  RESULTS
  Differences in sedation, itching, nausea and vomiting, motoric and sensoric disturbances, need of antihistamines, antiemetics, and ketoprofen were significant, the other parameters did not show any significant differences.
  
  
  CONCLUSIONS
  We recommend the use of ropivacaine with clonidine in the postoperative pain management after radical retropubic prostatectomy.
authors.affiliation: Onkologisches Institut in Ljubljana, Zaloska 2, 1000 Ljubljana, Slowenien. minca.voje@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Voje
authors.forename: A
authors.initials: A
authors.lastname: Manohin
mesh_terms: D000577:Amides / Q000009:adverse effects / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use*; D000779:Anesthetics, Local / Q000009:adverse effects / Q000627:therapeutic use*; D000932:Antiemetics / Q000627:therapeutic use; D003000:Clonidine / Q000009:adverse effects / Q000627:therapeutic use*; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009020:Morphine / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000601:surgery*; D011468:Prostatectomy; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000700:Analgesics; D000779:Anesthetics, Local; D000932:Antiemetics; D006633:Histamine Antagonists; D009020:Morphine; D000077212:Ropivacaine; D003000:Clonidine