What other biologic and mechanical factors might contribute to osteolysis?
An overwhelming consensus exists that wear particles are the primary driving force in aseptic loosening of orthopaedic implants. Nonetheless, considerable evidence has emerged demonstrating that various other factors can modulate the biologic activity of orthopaedic wear particles. Two of the most studied modulating factors are bacterial endotoxins and implant motion.
Greenfield
Ed M
EM
Department of Orthopaedics, Case Western Reserve University, Cleveland, OH, USA.
Bechtold
Joan
J
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019643:Arthroplasty, Replacement / Q000009:adverse effects*; D019544:Equipment Failure Analysis; D006801:Humans; D007595:Joint Prosthesis; D008070:Lipopolysaccharides / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D010014:Osteolysis / Q000188:drug therapy / Q000209:etiology*; D020959:Polyethylene; D011474:Prosthesis Design; D011475:Prosthesis Failure; D013314:Stress, Mechanical
D000900:Anti-Bacterial Agents; D008070:Lipopolysaccharides; D020959:Polyethylene