[A case of primary breast cancer who responded remarkably to the neoadjuvant chemotherapy with the combination of docetaxel and cyclophosphamide].
A 67-year-old woman visited our hospital with suspicion of right breast cancer. She underwent core needle biopsy, and her disease was diagnosed as breast cancer (invasive ductal carcinoma, ER- and PgR- positive, HER2-negative). We chose neoadjuvant chemotherapy, because the tumor size was over 3 cm in diameter and she wished to conserve her breast. She was elderly, and so without anthracycline base, we used a combination of docetaxel (75 mg/m(2)) and cyclophosphamide (600 mg/m(2)) q3w 6 cycles followed by breast-conserving therapy. During treatment, the patient remained very well and showed no major side effects except grade 4 neutropenia on an outpatient basis. After 6 cycles, ultrasonography and mammography indicated the residual tumor, but breast MRI did not detect any tumor. Pathological examination showed absence of invasive tumor or only focal residual tumor cells (QpCR). We concluded that the combination of docetaxel and cyclophosphamide was a good option for neoadjuvant chemotherapy for early breast cancer.
Yoshibayashi
Hiroshi
H
Dept. of Surgery (Breast Surgery), Kyoto University Hospital.
Ishiguro
Hiroshi
H
Takada
Masahiro
M
Takeuchi
Megumi
M
Yamashiro
Hiroyasu
H
Ueno
Takayuki
T
Kato
Hironori
H
Yoshikawa
Kiyotsugu
K
Kanao
Shotaro
S
Yamauchi
Chikako
C
Mikami
Yoshiki
Y
Toi
Masakazu
M
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003520:Cyclophosphamide / Q000627:therapeutic use*; D000077143:Docetaxel; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D020360:Neoadjuvant Therapy; D043823:Taxoids / Q000627:therapeutic use*
D043823:Taxoids; D000077143:Docetaxel; D003520:Cyclophosphamide