Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis.
Eight prenylated xanthones, bannaxanthones A-H (1-8), together with seven known compounds, were isolated from the acetone extract of the twigs of Garcinia xipshuanbannaensis. Their structures were elucidated by spectroscopic data interpretation. The cytotoxic activities of these compounds were evaluated using the MTT method. The results showed that xanthones with an unsaturated prenyl group had stronger cytotoxic activity against cancer cells, whereas those with hydroxylated prenyl groups had none.
Han
Quan-Bin
QB
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, Hong Kong, PR China.
Yang
Nian-Yun
NY
Tian
Hong-Lei
HL
Qiao
Chun-Feng
CF
Song
Jing-Zheng
JZ
Chang
Donald C
DC
Chen
Shi-Lin
SL
Luo
Kathy Q
KQ
Xu
Hong-Xi
HX
D049109:Cell Proliferation / Q000187:drug effects; D029760:Garcinia / Q000737:chemistry*; D006131:Growth Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D044004:Xanthones / Q000737:chemistry / Q000494:pharmacology*
D006131:Growth Inhibitors; D044004:Xanthones