title: Anaphylactic reaction after systemic application of aprotinin triggered by aprotinin-containing fibrin sealant.
abstract: We report a 67-yr-old male after multiple surgical procedures for treatment of arterial occlusive disease who suffered an anaphylactic reaction after administration of aprotinin (Trasylol) prior to urgent coronary artery bypass surgery. The patient had been treated with aprotinin-containing fibrin sealant in 2004 and in 2007, 2 wk before coronary artery bypass surgery. The postoperative serologic screening revealed positive results for qualitative aprotinin-specific IgG, highly elevated quantitative aprotinin-specific IgG and moderately elevated aprotinin-specific IgE antibodies.
authors.affiliation: Division of Thoracic, Cardiac and Vascular Surgery, Tübingen University Hospital, Hoppe-Seyler-Strasse 3, D-72076 Tübingen, Germany.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Kober
authors.forename: Albertus M
authors.initials: AM
authors.lastname: Scheule
authors.forename: Vladimir
authors.initials: V
authors.lastname: Voth
authors.forename: Norbert
authors.initials: N
authors.lastname: Deschner
authors.forename: Eckhard
authors.initials: E
authors.lastname: Schmid
authors.forename: Gerhard
authors.initials: G
authors.lastname: Ziemer
mesh_terms: D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced*; D007611:Aprotinin / Q000009:adverse effects*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001026:Coronary Artery Bypass; D015718:Fibrin Tissue Adhesive / Q000009:adverse effects*; D006490:Hemostatics / Q000009:adverse effects*; D006801:Humans; D008297:Male; D015842:Serine Proteinase Inhibitors / Q000009:adverse effects*
chemical_list: D015718:Fibrin Tissue Adhesive; D006490:Hemostatics; D015842:Serine Proteinase Inhibitors; D007611:Aprotinin