title: Preparation of aryloxetanes and arylazetidines by use of an alkyl-aryl suzuki coupling.
abstract: The oxetan-3-yl and azetidin-3-yl substituents have previously been identified as privileged motifs within medicinal chemistry. An efficient approach to installing these two modules into aromatic systems, using a nickel-mediated alkyl-aryl Suzuki coupling, is presented.
authors.affiliation: Evotec (USA), Two Corporate Drive, South San Francisco, California 94080, USA. mattduncton@yahoo.com
authors.forename: Matthew A J
authors.initials: MA
authors.lastname: Duncton
authors.forename: M Angels
authors.initials: MA
authors.lastname: Estiarte
authors.forename: Darlene
authors.initials: D
authors.lastname: Tan
authors.forename: Carl
authors.initials: C
authors.lastname: Kaub
authors.forename: Donogh J R
authors.initials: DJ
authors.lastname: O'Mahony
authors.forename: Russell J
authors.initials: RJ
authors.lastname: Johnson
authors.forename: Matthew
authors.initials: M
authors.lastname: Cox
authors.forename: William T
authors.initials: WT
authors.lastname: Edwards
authors.forename: Min
authors.initials: M
authors.lastname: Wan
authors.forename: John
authors.initials: J
authors.lastname: Kincaid
authors.forename: Michael G
authors.initials: MG
authors.lastname: Kelly
mesh_terms: D001384:Azetidines / Q000138:chemical synthesis*; D001555:Benzene Derivatives / Q000138:chemical synthesis*; D004988:Ethers, Cyclic / Q000138:chemical synthesis*
chemical_list: D001384:Azetidines; D001555:Benzene Derivatives; D004988:Ethers, Cyclic; C005287:oxetane