title: 1-O-Substituted derivatives of murrayafoline A and their antifungal properties.
abstract: The synthesis of some 1-oxygenated derivatives of murrayafoline A (1) and their antifungal properties is reported. Three derivatives, 1-hydroxy-3-methyl-9H-carbazole (2), 1-(3-methylbut-2-enyloxy)-3-methyl-9H-carbazole (3) and 1-(2,3,4,6,-tetra-O-acetyl-alpha-D-O-glucopyranosyl)-3-methyl-9H-carbazole (4), of murrayafoline A were synthesized. Compounds 1 and 2 exhibit strong fungicidal activity against Cladosporium cucumerinum at the dose of 12.5 microg.
authors.affiliation: Institute of Chemistry, Vietnamese Academy of Science and Technology, 18 Hoang Quoc Viet St., Hanoi, Vietnam 122100. nmcuong@ich.vast.ac.vn
authors.forename: Nguyen Manh
authors.initials: NM
authors.lastname: Cuong
authors.forename: Heike
authors.initials: H
authors.lastname: Wilhelm
authors.forename: Andrea
authors.initials: A
authors.lastname: Porzel
authors.forename: Norbert
authors.initials: N
authors.lastname: Arnold
authors.forename: Ludger
authors.initials: L
authors.lastname: Wessjohann
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002963:Cladosporium / Q000187:drug effects; D006031:Glycosylation; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D054876:Prenylation
chemical_list: D000470:Alkaloids; D000935:Antifungal Agents; D002227:Carbazoles; C443728:murrayafoline A; C041514:carbazole