title: Cellular uptake and cytotoxicity of silica nanotubes.
abstract: "Template synthesized" silica nanotubes (SNTs) provide unique features such as end functionalization to control drug release, inner voids for loading biomolecules, and distinctive inner and outer surfaces that can be differentially functionalized for targeting and biocompatibility. Very limited information is available about their biological interactions. This work evaluates the influence of size and surface charge of SNTs on cellular toxicity and uptake. Results additionally indicate endocytosis to be one possible mechanism of internalization of SNTs.
authors.affiliation: Center for Nanomedicine and Cellular Delivery, University of Maryland, Baltimore, Maryland, USA.
authors.forename: Anjan
authors.initials: A
authors.lastname: Nan
authors.forename: Xia
authors.initials: X
authors.lastname: Bai
authors.forename: Sang Jun
authors.initials: SJ
authors.lastname: Son
authors.forename: Sang Bok
authors.initials: SB
authors.lastname: Lee
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Ghandehari
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003603:Cytotoxins / Q000378:metabolism* / Q000633:toxicity*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes / Q000633:toxicity* / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000378:metabolism* / Q000633:toxicity*
chemical_list: D003603:Cytotoxins; D012822:Silicon Dioxide