Botulinum toxin type A as an adjuvant treatment modality for extensive Hailey-Hailey disease.
BACKGROUND
Extensive Hailey-Hailey disease is often resistant to conventional topical and systemic therapies. The systemic and ablative therapies have many side effects and/or high recurrence rates. Therefore, an alternative safe and effective treatment is needed.


OBJECTIVE
To assess the effectiveness of botulinum toxin type A in the treatment of extensive Hailey-Hailey disease.


METHODS
The cases of six patients with extensive Hailey-Hailey disease resistant to multiple therapeutic regimens were studied and described. Adjuvant therapy with botulinum toxin type A/Dysport was started in all six cases.


RESULTS
Marked improvement of the lesions was achieved with few side effects in all patients.


CONCLUSIONS
Botulinum toxin type A is a safe and effective adjuvant treatment for extensive Hailey-Hailey disease.
Koeyers
Wendy Jane
WJ
Catharina Hospital Eindhoven, Eindhoven, The Netherlands. w.koeyers@erasmusmc.nl
Van Der Geer
Simone
S
Krekels
Gertruud
G
D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D016506:Pemphigus, Benign Familial / Q000188:drug therapy* / Q000473:pathology
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A