Severe hypothyroidism after contrast enema in premature infants.
Premature newborns are particularly vulnerable to iatrogenic hypothyroidism due to iodine exposure, usually through skin absorption of iodine-containing disinfectants or intravenous administration of iodinated contrast agents. We report here a case of severe iatrogenic hypothyroidism with goiter and cholestasis, discovered six weeks after a contrast enema using sodium ioxitalamate, an iodinated contrast agent. Prematurity, intrauterine growth retardation, and enteral feeding intolerance could explain why this complication occurred after contrast enema. Our observations suggest that indications of contrast enema in neonates need to be carefully considered, and when necessary, thyroid function should be monitored, especially in very premature infants.
Lombard
Fanny
F
CHU de Montpellier, Service de Néonatologie (Pédiatrie 2), Hôpital A. de Villeneuve, Montpellier, 34000, France.
Dalla-Vale
Fabienne
F
Veyrac
Corinne
C
Plan
Odile
O
Cambonie
Gilles
G
Picaud
Jean-Charles
JC
D002779:Cholestasis / Q000139:chemically induced / Q000175:diagnosis; D003287:Contrast Media / Q000009:adverse effects*; D004733:Enema / Q000009:adverse effects*; D006042:Goiter / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D007049:Iatrogenic Disease; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D007455:Iodine / Q000009:adverse effects*; D008297:Male; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use; D014284:Triiodothyronine / Q000097:blood; D014463:Ultrasonography
D003287:Contrast Media; D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine