A study on the chemical constituents of Veratrum nigrum L. processed by rice vinegar.
One new steroid alkaloid, 12beta-hydroxylveratroylzygadenine (1) and four known compounds, verdine (2), jervine (3), veramarine (4), and veratroylzygadenine (5), have been isolated from the roots and rhizomes of Veratrum nigrum L. processed by rice vinegar. Their structures were established through a combined analysis of physicochemical properties and spectroscopic evidence. The assay results revealed that compounds 1, 4, and 5 exhibited cell toxicity against human HL-60 cells with IC50 values 52.67, 52.90, and 56.51 micromol/l, respectively.
Cong
Yue
Y
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Wang
Jin-Hui
JH
Wang
Rui
R
Zeng
Yi-Mei
YM
Liu
Chang-Da
CD
Li
Xian
X
D019342:Acetic Acid / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D018517:Plant Roots / Q000737:chemistry; D014703:Veratrum / Q000737:chemistry*
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D019342:Acetic Acid