Highly Direct alpha-Selective Glycosylations of 3,4-O-Carbonate-Protected 2-Deoxy- and 2,6-Dideoxythioglycosides by Preactivation Protocol.
A new efficient pre-activation method for the highly alpha-stereoselective glycosylation of 2-deoxysugars and 2,6-dideoxysugars has been developed using 2-deoxy- and 2,6-dideoxythioglycosides as glycosyl donors. The approach allows a wide range of glycosyl acceptors and donors to be used; the alpha-selectivity is very good to excellent.
Lu
Yin-Suo
YS
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd #38, Beijing 100083, China.
Li
Qin
Q
Zhang
Li-He
LH
Ye
Xin-Shan
XS
D002236:Carbohydrate Conformation; D002254:Carbonates / Q000737:chemistry*; D006031:Glycosylation; D013237:Stereoisomerism; D013865:Thioglycosides / Q000138:chemical synthesis* / Q000737:chemistry
D002254:Carbonates; D013865:Thioglycosides