Development of a practical Buchwald-Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst.
Continuing efforts to establish a more general "user-friendly" protocol for the palladium-catalysed arylation of amines (Buchwald-Hartwig reaction) are described herein. Significant advances have been made through the use of the versatile (SIPr)Pd(methallyl)Cl complex in conjunction with the reliable base lithium hexamethyldisilazide (LHMDS).
Cawley
Mark J
MJ
Department of Chemistry, University College London, London, UK.
Cloke
F Geoffrey N
FG
Fitzmaurice
Richard J
RJ
Pearson
Stuart E
SE
Scott
James S
JS
Caddick
Stephen
S
D000588:Amines / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009025:Morpholines / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D000588:Amines; D001555:Benzene Derivatives; D009025:Morpholines; D009942:Organometallic Compounds; D010165:Palladium; C037574:morpholine