title: Exceptional behavior over the whole adsorption-storage-delivery cycle for NO in porous metal organic frameworks.
abstract: Two porous metal organic frameworks (MOFs), [M2(C8H2O6)(H2O)2] x 8 H2O (M = Co, Ni), perform exceptionally well for the adsorption, storage, and water-triggered delivery of the biologically important gas nitric oxide. Adsorption and powder X-ray diffraction studies indicate that each coordinatively unsaturated metal atom in the structure coordinates to one NO molecule. All of the stored gas is available for delivery even after the material has been stored for several months. The combination of extremely high adsorption capacity (approximately 7 mmol of NO/g of MOF) and good storage stability is ideal for the preparation of NO storage solids. However, most important is that the entire reservoir of stored gas is recoverable on contact with a simple trigger (moisture). The activity of the NO storage materials is proved in myography experiments showing that the NO-releasing MOFs cause relaxation of porcine arterial tissue.
authors.affiliation: EaStChem School of Chemistry, University of St Andrews, Purdie Building, St Andrews KY16 9ST, UK.
authors.forename: Alistair C
authors.initials: AC
authors.lastname: McKinlay
authors.forename: Bo
authors.initials: B
authors.lastname: Xiao
authors.forename: David S
authors.initials: DS
authors.lastname: Wragg
authors.forename: Paul S
authors.initials: PS
authors.lastname: Wheatley
authors.forename: Ian L
authors.initials: IL
authors.lastname: Megson
authors.forename: Russell E
authors.initials: RE
authors.lastname: Morris
mesh_terms: D000327:Adsorption; D000818:Animals; D001158:Arteries / Q000187:drug effects; D004355:Drug Stability; D015394:Molecular Structure; D009213:Myography; D009569:Nitric Oxide / Q000008:administration & dosage*; D009942:Organometallic Compounds / Q000737:chemistry*; D016062:Porosity; D013552:Swine; D014664:Vasodilation / Q000187:drug effects
chemical_list: D009942:Organometallic Compounds; D009569:Nitric Oxide