[Survival of transgenic mouse embryos carrying different genetic constructs].
The survival of transgenic mouse embryos was studied as a function of the transgene structure. The data obtained indicate that the introduction of a chromosomal DNA fragment providing for the anchoring of interphase chromosomes on the nuclear envelope increases the efficiency of transgenesis in mice threefold due to their increased viability.
Glazkov
M V
MV
Drozd
S F
SF
Golovatenko-Abramov
P K
PK
Martynova
M Iu
MIu
Nesterova
A P
AP
D000818:Animals; D033481:Chromosomes, Mammalian / Q000235:genetics* / Q000378:metabolism; D004622:Embryo, Mammalian / Q000166:cytology / Q000378:metabolism*; D005260:Female; D018014:Gene Transfer Techniques; D007399:Interphase / Q000502:physiology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008822:Mice, Transgenic; D009685:Nuclear Envelope / Q000235:genetics / Q000378:metabolism*; D019076:Transgenes / Q000502:physiology*