Association of glucose transporter 1 polymorphisms with type 2 diabetes in the Tunisian population.
BACKGROUND
T2DM is a complex metabolic disease. Genetic studies on T2DM have been of little help so far because several genetic association studies have shown conflicting results. In this study, we report the findings of a case-control study on three SNPs in the GLUT1 gene. For this, we investigated the association of GLUT1 genotypes and haplotypes with T2DM.


METHODS
All 273 T2DM subjects (cases) and 343 healthy subjects (controls) were genotyped using the polymerase chain reaction restriction fragment length polymorphism.


RESULTS
Results showed that the GT genotype of XbaI SNP could increase the risk of susceptibility to T2DM to 2.4 and that TAT is a 'risk haplotype' conferring a risk of 3.4 to T2DM.


CONCLUSIONS
The TAT haplotype of the GLUT1 gene confers susceptibility to T2DM in the Tunisian population.
Makni
K
K
Research Unit 'Targets for Diagnostic and Therapy of Human Diseases', Centre of Biotechnology of Sfax, and Laboratoire International Associé No 135, Sfax, Tunisia. kaouthar2005@gmail.com
Mnif
F
F
Boudawara
M
M
Hamza
N
N
Rekik
N
N
Abid
M
M
Rebaï
A
A
Jarraya
F
F
Granier
C
C
Ayadi
H
H
D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D051272:Glucose Transporter Type 1 / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014416:Tunisia / Q000453:epidemiology
D051272:Glucose Transporter Type 1; C495677:SLC2A1 protein, human