title: S100 protein expression distinguishes metanephric adenomas from other renal neoplasms.
abstract: Metanephric adenoma is a benign renal neoplasm with morphologic features similar to those of malignant renal neoplasms, such as papillary renal cell carcinoma (RCC) and Wilms' tumor. Different methods have been used to distinguish between metanephric adenoma and papillary RCC and Wilms' tumor. However, some techniques are not always available, such as certain immunohistochemical stains, cytogenetics, molecular genetics, and electron microscopy. In the current study, we compared the expression of S100 protein in 15 cases of metanephric adenoma, 10 cases of Wilms' tumor, and 13 cases of papillary RCC. Our results revealed strong expression of S100 proteins in all cases of metanephric adenoma, weak expression in two cases of Wilms' tumor, and no expression in any of the cases of papillary RCC. These findings indicate that S100 could be a useful and accessible tool for the diagnosis of metanephric adenoma.
authors.affiliation: Department of Pathology, Tufts University School of Medicine and New England Medical Center, 136 Harrison Avenue, Boston, MA 02111, USA.
authors.forename: Gissou
authors.initials: G
authors.lastname: Azabdaftari
authors.forename: Joseph
authors.initials: J
authors.lastname: Alroy
authors.forename: Barbara F
authors.initials: BF
authors.lastname: Banner
authors.forename: Angelo
authors.initials: A
authors.lastname: Ucci
authors.forename: Ina
authors.initials: I
authors.lastname: Bhan
authors.forename: John C
authors.initials: JC
authors.lastname: Cheville
mesh_terms: D000236:Adenoma / Q000737:chemistry* / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry* / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis*; D009396:Wilms Tumor / Q000737:chemistry* / Q000473:pathology
chemical_list: D009418:S100 Proteins