The bite-raised condition in aged SAMP8 mice induces dendritic spine changes in the hippocampal region.
The present study examined the effect of the bite-raised condition on the number of dendritic spines on hippocampal pyramidal cells in SAMP8 mice and related the results with learning ability in a water maze test. Aged mice in the bite-raised condition had reduced learning ability and a lower number of CA1 pyramidal cell dendritic spines. The results suggest that the bite-raised condition exacerbates the age-related spatial learning impairment, and that this may be due to the degeneration of hippocampal dendritic spines.
Kubo
Kin-ya
KY
Department of Oral Anatomy, Division of Oral Structure, Function and Development, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan. kubo@dent.asahi-u.ac.jp
Kojo
Akiko
A
Yamamoto
Toshiharu
T
Onozuka
Minoru
M
D000367:Age Factors; D000375:Aging / Q000235:genetics / Q000502:physiology*; D019588:Aging, Premature / Q000473:pathology*; D000818:Animals; D001522:Behavior, Animal; D049229:Dendritic Spines / Q000473:pathology*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000473:pathology*; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains; D017966:Pyramidal Cells / Q000473:pathology / Q000648:ultrastructure*; D011930:Reaction Time; D016622:Silver Staining / Q000379:methods; D013315:Stress, Psychological / Q000235:genetics / Q000503:physiopathology*; D013550:Swimming; D013997:Time Factors