The second chance story of HIV-1 DNA: Unintegrated? Not a problem!
Accumulation of high levels of unintegrated viral DNA is a common feature of retroviral infection. It was recently discovered that coinfection of cells with integrated and unintegrated HIV-1 can result in complementation, allowing viral replication in the absence of integration. This new mode of HIV-1 replication has numerous implications for the function of unintegrated viral DNA and its application as a therapeutic vector.
Wu
Yuntao
Y
Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA. ywu8@gmu.edu
D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism*; D015658:HIV Infections / Q000821:virology; D019427:HIV Integrase / Q000235:genetics; D015497:HIV-1 / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D054298:Human Immunodeficiency Virus Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D013997:Time Factors; D014158:Transcription, Genetic; D014771:Virion / Q000378:metabolism; D016662:Virus Integration / Q000502:physiology*; D014779:Virus Replication
D004279:DNA, Viral; D054298:Human Immunodeficiency Virus Proteins; D019427:HIV Integrase