title: Body weight through adult life and risk of urinary incontinence in middle-aged women: results from a British prospective cohort.
abstract: OBJECTIVE
  To determine whether the onset and duration of being overweight or obese are associated with symptoms of urinary incontinence.
  
  
  METHODS
  Nationally representative cohort study.
  
  
  METHODS
  A total of 1201 women followed-up since their birth in 1946 and annually from 48 to 54 years.
  
  
  METHODS
  The body mass index (BMI) at the age of 20, 26, 36 and 43, and symptoms of stress, urge and severe incontinence at seven consecutive years from age 48 to 54.
  
  
  RESULTS
  In each year from age 48 to 54, almost half (46-49%) reported symptoms of stress incontinence, urge incontinence rose from 22 to 25% and severe incontinence from 8 to 11%. At the age of 20, 26, 36 and 43, BMI was positively associated with stress symptoms and severe incontinence in midlife. BMI transition was found to have accumulation effects on symptoms of severe incontinence; women who were overweight/obese since age 20 years were more likely to report severe incontinence than women whose BMI remained below 25 kg/m(2) (odds ratio (95% confidence interval): 2.30 (1.36-3.93)) or who became overweight or obese at 43 years (1.85 (0.97-3.51)). These relationships existed beyond the effects of aging, childhood enuresis, kidney infection, childbirth characteristics, menopause, educational attainment, general practitioner consultations and smoking status. BMI was not associated with symptoms of urge incontinence.
  
  
  CONCLUSIONS
  Across adult life, higher BMI for women was linked with subsequent symptoms of stress and severe incontinence in midlife; those who were overweight or obese since early in adult life more than doubled their risk of severe incontinence. Women, and especially young women, should be encouraged to keep their weight in a normal range throughout adult life.
authors.affiliation: MRC unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College and Royal Free Medical School, London, UK. g.mishra@nshd.mrc.ac.uk
authors.forename: G D
authors.initials: GD
authors.lastname: Mishra
authors.forename: R
authors.initials: R
authors.lastname: Hardy
authors.forename: L
authors.initials: L
authors.lastname: Cardozo
authors.forename: D
authors.initials: D
authors.lastname: Kuh
mesh_terms: D015992:Body Mass Index; D015986:Confounding Factors, Epidemiologic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D050177:Overweight / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology; D014549:Urinary Incontinence / Q000453:epidemiology / Q000209:etiology*; D014550:Urinary Incontinence, Stress / Q000453:epidemiology / Q000209:etiology; D053202:Urinary Incontinence, Urge / Q000453:epidemiology / Q000209:etiology; D055815:Young Adult