Treatment of bacterial infections in children with sultamicillin.
Infections caused by beta-lactamase-producing pathogens should be treated with beta-lactamase-stable antibiotics or with penicillin-derivatives in combination with inhibitors. Sulbactam, which acts as a beta-lactamase inhibitor, works in conjunction with ampicillin by extending the spectrum of ampicillin to include ampicillin-resistant germs. Sultamicillin is an active substance that combines sulbactam and ampicillin to form an ester. Sultamicillin's bio-availability remains high even after eating. For children, the dosage is 50 mg/kg/day, in two doses. The prospective study of 100 patients of between 6 months and 12 years of age with respiratory, skin, and mucous membrane infections produced a therapy success rate of 90%. The most significant side-effects were exanthemas and diarrhoea.
Scholz
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H
Paediatric Institute for Infectious Diseases, Institute for Infectiology, Microbiology and Hygiene, Berlin-Buch, Wiltbergstrasse 50, D-13125 Berlin-Buch, Germany.
Märker
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Rockstroh
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