[Impact of single nucleotide polymorphisms in glutathione S transferase gene GSTP1 in the treatment with oxaliplatin based chemotherapy].
Oxaliplatin has been the main treatment of choice in colorectal cancer in advanced settings. However, cellular mechanisms for the uptake, intracellular distribution and efflux of oxaliplatin are unknown. GST(glutathione S transferase)is member of a superfamily of metabolic enzymes that play an important role in the cell defense system. Current data suggest that GST-pi is associated with increased resistance to platinum-based chemotherapy. Specific roles for the single nucleotide polymorphisms in GST-pi gene GSTP1 in the treatment with oxaliplatin based chemotherapy, have been demonstrated in recent years.
Oki
Eiji
E
Dept. of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kakeji
Yoshihiro
Y
Ohgaki
Kippei
K
Saeki
Kohji
K
Morita
Masaru
M
Emi
Yasunori
Y
Maehara
Yoshihiko
Y
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005982:Glutathione Transferase / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D000077150:Oxaliplatin; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013379:Substrate Specificity
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D005982:Glutathione Transferase