title: Effects of escapable and inescapable stressors on behavior and interleukin-2 in the brain.
abstract: This study aimed to clarify the effects of inescapable and escapable stressors on behavior and interleukin-2 (IL-2) levels in the brain. Inescapable trials, consisting of pairings of conditioned and unconditioned stimuli, were used to induce fear-conditioned stress, whereas trials of escapable pairings of conditioned and unconditioned stimuli in an active avoidance test were used as acute and conditioned stressors. IL-2 levels in the brain were analyzed by enzyme-linked immunoadsorbent assays. Inescapable and escapable stressors had different effects on behavior in the modified active avoidance test and on IL-2 levels in brain areas that are known to be involved in emotional processes. These data provide insight into the pathophysiological role of IL-2 in stress-related disorders.
authors.affiliation: Institute of Behavioral Medicine, Cheng Kung University, Taiwan, Republic of China.
authors.forename: Yen-Ti
authors.initials: YT
authors.lastname: Lee
authors.forename: Wen-Fu
authors.initials: WF
authors.lastname: Wang
authors.forename: Chun-Wen
authors.initials: CW
authors.lastname: Cheng
authors.forename: Shey-Lin
authors.initials: SL
authors.lastname: Wu
authors.forename: Cornelius R
authors.initials: CR
authors.lastname: Pawlak
authors.forename: Ying-Jui
authors.initials: YJ
authors.lastname: Ho
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D003214:Conditioning, Classical / Q000502:physiology; D003216:Conditioning, Operant / Q000502:physiology; D004597:Electroshock / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay; D004924:Escape Reaction / Q000502:physiology*; D005239:Fear / Q000502:physiology / Q000523:psychology; D046352:Freezing Reaction, Cataleptic / Q000502:physiology; D005793:Generalization, Psychological / Q000502:physiology; D006380:Helplessness, Learned; D007376:Interleukin-2 / Q000032:analysis*; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000503:physiopathology
chemical_list: D007376:Interleukin-2