[Study on the effect of Part III from Cynomorium songaricum on immunosuppressive mice induced by cyclophosphamide].
OBJECTIVE
To study the immunomodulatory effect of Part III of Cynomorium songaricum Rupr. on the immunosuppressive mice.


METHODS
The immunity-deficiency model was induced by intraperitoneal injection of cyclophosphamide (CTX) at the dose of 100 mg/kg in mice; all the animals were divided into normal control group, immunity-deficiency model group, Part III treated group (300 mg/kg) and positive control group (TSPG, 300 mg/kg). The hemogram of peripheral blood, the index of immune organs, the phagocytosis activity of macrophage, the content of serum hemolysin were measured.


RESULTS
The index of organs, the phagocytosis activity of macrophage and the content of serum hemolysin in the model group increased after administrated of Part III.


CONCLUSIONS
Part III from Cynomorium songaricum Rupr. has protective effect on the immunosuppressive mice, which may be related to the increasing of humoral immunity and nonspecific immunity.
Zhang
Ru-Xue
RX
Lanzhou General Hospital, Lanzhou Command of PLA, Lanzhou 730050, China. empriqqq@public.lz.gs.cn
Jia
Zheng-Ping
ZP
Li
Mao-Xing
MX
Wang
Juan
J
Yin
Qiang
Q
Luo
Jun-De
JD
Liu
Hong-Yan
HY
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity; D031482:Cynomorium / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006460:Hemolysin Proteins / Q000097:blood; D007109:Immunity / Q000187:drug effects*; D016867:Immunocompromised Host / Q000187:drug effects* / Q000276:immunology; D007166:Immunosuppressive Agents / Q000633:toxicity; D018655:Lymphocyte Count; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D010586:Phagocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000473:pathology
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D006460:Hemolysin Proteins; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide