Evolving management of colorectal cancer.
This article reviews recent advances in surgical techniques and adjuvant therapies for colorectal cancer, including total mesorectal excision, the resection of liver and lung metastasis and advances in chemoradiation and foreshadows some interventions that may lie just beyond the frontier. In particular, little is known about the intracellular and extracellular cascades that may influence colorectal cancer cell adhesion and metastasis. Although the phosphorylation of focal adhesion kinases and focal adhesion associated proteins in response to integrin-mediated cell matrix binding ("outside in integrin signaling") is well described, the stimulation of cell adhesion by intracellular signals activated by pressure prior to adhesion represents a different signal paradigm. However, several studies have suggested that increased pressure and shear stress activate cancer cell adhesion. Further studies of the pathways that regulate integrin-driven cancer cell adhesion may identify ways to disrupt these signals or block integrin-mediated adhesion so that adhesion and eventual metastasis can be prevented in the future.
van der Voort van Zijp
Jochem
J
Department of Radiation Oncology, Leiden University Medical Center, Postbus 9600, Leiden RC 2333, The Netherlands. j.r.n.van_der_voort_van_zijp@lumc.nl
Hoekstra
Harald J
HJ
Basson
Marc D
MD
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002448:Cell Adhesion; D017024:Chemotherapy, Adjuvant / Q000639:trends; D003082:Colectomy / Q000639:trends*; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D015994:Incidence; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D015995:Prevalence; D018714:Radiotherapy, Adjuvant / Q000639:trends; D015398:Signal Transduction; D016896:Treatment Outcome