Synthesis of alpha-helix mimetics with four side-chains.
The synthesis of a heterocyclic piperazine-based scaffold that mimics the i, i+4, i+8, i+11 side-chain projections of an alpha-helix is described. The synthesis is designed to be modular to allow the targeting of a range of protein-protein interactions involving alpha-helices.
Restorp
Per
P
The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd, MB-26, La Jolla, CA 92037, USA.
Rebek
Julius
J
D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry*; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*
D010879:Piperazines; D011506:Proteins