The convenient synthesis and evaluation of the anticancer activities of new resveratrol derivatives.
In the present study we report the simple synthesis and antitumour activity of novel stilbene derivatives 13-22. The key synthetic strategies involved Wadsworth-Horner-Emmons condensation and coupling reactions in high yields. All compounds showed significant growth inhibition on human tumour cell lines, with the most potent compound (19) exhibiting an IC(50) of 5.7 microM-11.4 microM in vitro.
Moon
Hyung-In
HI
Department of Neuroscience and, Inam Neuroscience Research Center, Sanbon Medical Center, Wonkwang University, Kyunggido, South Korea.
Chung
Ill-Min
IM
Jung
Jae-Chul
JC
Lim
Eunyoung
E
Lee
Yongnam
Y
Oh
Seikwan
S
Jung
Mankil
M
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D000077185:Resveratrol; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; D000077185:Resveratrol