title: Pd-catalyzed sequential reactions via allene intermediate for the synthesis of polycyclic frameworks containing 2,3-dihydrofuran units.
abstract: A stepwise process involving Sonogashira coupling, propargyl allenyl isomerization, and consecutive [4 + 2] cyclization has been realized, leading to an efficient synthesis of polycyclic compounds containing a 2,3-dihydrofuran unit. Most attractive for synthetic interest is the finding that up to four stereogenic centers could be generated in one step with high stereoselectivity.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310028, P. R. China.
authors.forename: Ruwei
authors.initials: R
authors.lastname: Shen
authors.forename: Xian
authors.initials: X
authors.lastname: Huang