Oral pseudomonas aeruginosa immunization enhances survival in mice subsequently burned and infected with P. aeruginosa.
Mice fed 0 serotype-specific strains of P. aeruginosa for two weeks, had increased titers of IgM but not IgG antibodies to the strains fed. Immunized mice, burned and infected with P. aeruginosa, showed significant 0 serotype-specific enhanced survival. Survival of mice fed several 0 serotype-specific strains simultaneously increased when these mice were burned and infected with P. aeruginosa homologous to those fed except when a high exotoxin A producing strain was used. Mice fed purified exotoxin A showed an increased LD(50) when injected with graded toxin doses. Feeding both 0 serotype-specific P. aeruginosa plus exotocin A increased survival even with burn and infection using the high toxin producing strain. We conclude that feeding P. aeruginosa antigens provides successful immunization which avoids the effects of parental adminstration.
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Departments of Surgery, Molecular Genetics, Biochemistry, Microbiology, Physiology and Biophysics, University of Cincinnati College of Medicine, Shriners Burns Institute, Cincinnati, Ohio, USA.
Orloff
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Neely
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