[Dendritic cells and Th2 response induced by schistosome infection].
Dendritic cells act as the major antigen presenting cells in the body and play a central role in intriguing the adaptive immune response. Protective immunity against schistosome and immuno-pathological response in host caused by eggs are both closely associated with Th2 response. Further understanding on immune mechanism will contribute to the development of vaccines against schistosome infection, as well as the relief of the pathological lesion in schistosomiasis. This article discusses the central role of dendritic cells in the mechanism of Th2 response induced by schistosome (including eggs).
Zang
Wei
W
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, MOH, China.
Shen
Yu-Juan
YJ
Cao
Jian-Ping
JP
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D006790:Host-Parasite Interactions; D012547:Schistosoma / Q000502:physiology*; D012552:Schistosomiasis / Q000276:immunology / Q000469:parasitology*; D018418:Th2 Cells / Q000276:immunology*