title: What patient and surgical factors contribute to implant wear and osteolysis in total joint arthroplasty?
abstract: Total joint arthroplasty has been a successful operation for decades. Our current patients are younger and more active than those in the past. They place higher demands on themselves and have expectations commensurate with their lifestyles. Time-limited longevity with the large number of anticipated total joint replacement procedures and their potential burden to health care is a growing concern. In the past two decades, implant wear and osteolysis have been identified as major causes for the failure of otherwise well-functioning implants. Osteolysis can be divided into several categories: patient-specific, implant-specific, and the result of surgical factors. Although these categories are interrelated and not mutually exclusive, they enable us to build a framework in which to further advance our understanding of osteolysis and apply this information in a clinically relevant manner.
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Audrey K
authors.initials: AK
authors.lastname: Tsao
authors.forename: Lynne C
authors.initials: LC
authors.lastname: Jones
authors.forename: David G
authors.initials: DG
authors.lastname: Lewallen
mesh_terms: D019643:Arthroplasty, Replacement / Q000009:adverse effects* / Q000379:methods; D019544:Equipment Failure Analysis / Q000706:statistics & numerical data; D006801:Humans; D007595:Joint Prosthesis; D008019:Life Style; D010014:Osteolysis / Q000453:epidemiology* / Q000209:etiology*; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012086:Reoperation; D012307:Risk Factors; D013314:Stress, Mechanical; D013499:Surface Properties