Anti-cyclic citrullinated peptide antibodies in lung diseases associated with rheumatoid arthritis.
OBJECTIVE
Anti-cyclic citrullinated peptide (anti-CCP) antibodies are highly specific markers for rheumatoid arthritis (RA) and useful for predicting RA development and progression. However, it has not been fully determined whether anti-CCP antibodies are associated with pulmonary diseases in RA patients. In the present study, we aimed to elucidate the relationships between anti-CCP antibodies and pulmonary diseases, particularly interstitial lung disease (ILD) and bronchiolitis.


METHODS
Using an enzyme-linked immunosorbent assay, the presence of serum anti-CCP antibodies was examined in 18 RA patients with ILD and bronchiolitis who were diagnosed based on pathologic findings. A further 36 RA subjects without any pulmonary diseases served as a reference population.


RESULTS
No significant differences were found for the prevalences and levels of anti-CCP antibodies between patients with and without ILD and follicular bronchiolitis.


CONCLUSIONS
Detection of serum anti-CCP antibodies has no association with pulmonary diseases in RA patients.
Inui
Naoki
N
The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan. inui@hama-med.ac.jp
Enomoto
Noriyuki
N
Suda
Takafumi
T
Kageyama
Yasunori
Y
Watanabe
Hiroshi
H
Chida
Kingo
K
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D001988:Bronchiolitis / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000209:etiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D012189:Retrospective Studies
D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide