Association of single nucleotide polymorphisms in GATA-3 with allergic rhinitis.
CONCLUSIONS
The results of our study demonstrated the association between the single nucleotide polymorphisms (SNPs) of GATA-3 and allergic rhinitis (AR).


OBJECTIVE
AR is considered to be controlled by T-helper type 2 (Th2) cells. GATA-3 is the crucial transcription factor controlling the differentiation and function of Th2 cells. We aimed to evaluate the association between the SNPs of GATA-3 and AR.


METHODS
GATA-3 SNPs in 109 AR patients and 112 healthy controls in China were detected with restriction fragment length polymorphism.


RESULTS
The genotypes at rs1269486 were GG, GA, and AA, and the genotypes at rs2229360 were CC, CT, and TT. The frequency of the G allele in the patient group was significantly higher than that in the control group (p<0.01), while the frequency of the A allele in the patient group was significantly lower than that in the control group (p<0.01). Meanwhile, the haplotype frequency of GC at the two loci in the patient group was significantly higher than that in the control group (p<0.01), and the haplotype frequency of AC in the patient group was significantly lower than that in the control group (p<0.01).
Zhang
Luo
L
Key Laboratory Otolaryngology, Capital Medical University, Ministry of Education of China, Beijing Institute of Otorhinolaryngology, Beijing, PR China. luozhang@trhos.com
Wang
Xiangdong
X
Han
Demin
D
Duan
Hong
H
Zhao
Yan
Y
D000293:Adolescent; D000328:Adult; D000483:Alleles; D000485:Allergens / Q000276:immunology; D000818:Animals; D002648:Child; D002681:China; D002874:Chromosome Mapping; D018388:Codon, Terminator / Q000235:genetics; D005260:Female; D050990:GATA3 Transcription Factor / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D039981:Pyroglyphidae / Q000276:immunology; D012016:Reference Values; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics* / Q000276:immunology; D055815:Young Adult
D000485:Allergens; D018388:Codon, Terminator; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human; D007073:Immunoglobulin E