[Study on adscription of drug constituents in Beagle dog plasma after intragastric administration with Jiangzhining extract].
OBJECTIVE
To investigate the drug constituents in Beagle dog plasma after intragastric administration with Jiangzhining extract, which is a Chinese medicine prescription and it consisting of processed Radix Polygoni Multiflori, Fructus Crataegi, Semen Cassiae and Folium Nelumbinis.


METHODS
The drug constituents and their origin in Beagle dogs plasma were assigned by comparison of high-performance liquid chromatographic profiles, retention time and ultraviolet spectra of the drug-free plasma, plasma contained drug, Jiangzhining extract and the ingredients of crude drug.


RESULTS
Twenty-four components were detected after intragastric administration of Jiangzhining extract, among which eight compounds were the original components existed in Jiangzhining extract and sixteen compounds were likely to metabolites of the some chemical constituents in ingredients of crude drug.


CONCLUSIONS
Studies on the drug constituents and the metabolites in plasma after intragastric administration of Jiangzhining extract are useful to elucidate the effective substances of Jiangzhining prescription.
Wang
Fu-Gang
FG
Beijing University of Chinese Medicine, Beijing 100102, China.
Liu
Bin
B
Wang
Wei
W
Shi
Ren-Bing
RB
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D005260:Female; D008297:Male; D044967:Serum / Q000378:metabolism*; D013270:Stomach
D004365:Drugs, Chinese Herbal; C540314:Jiangzhining extract