title: TLR accessory molecules.
abstract: Accessory molecules are required for microbial recognition by Toll-like receptor (TLR), subsequent signaling, and regulation of ensuing immune responses. Accessory molecules regulate TLRs on the cell surface (MD-2 and RP105), or in the endoplasmic reticulum (ER) (Unc93B, PRAT4A, and gp96). Other types of accessory molecules modulate TLR responses by acting directly on TLR ligands (CD14, CD36, HMGB1, and the antimicrobial peptide LL37). These molecules cooperate with TLR, inducing appropriate defense mechanisms. It is important to understand how TLR signaling is controlled by these accessory molecules. These accessory molecules could be promising targets for therapeutic intervention in infectious disease and immune disorders.
authors.affiliation: Division of Infectious Genetics, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Akashi-Takamura
authors.forename: Kensuke
authors.initials: K
authors.lastname: Miyake
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism*; D023181:Antimicrobial Cationic Peptides / Q000276:immunology / Q000378:metabolism; D002352:Carrier Proteins / Q000276:immunology / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000276:immunology / Q000378:metabolism; D024243:HMGB1 Protein / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008024:Ligands; D051218:Lymphocyte Antigen 96 / Q000276:immunology / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D023181:Antimicrobial Cationic Peptides; D002352:Carrier Proteins; D024243:HMGB1 Protein; D008024:Ligands; D051218:Lymphocyte Antigen 96; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D051193:Toll-Like Receptors