title: QSAR of aromatic substances: EGFR inhibitory activity of quinazoline analogues.
abstract: The flip regression procedure that we used earlier for handling the xanthones system has been applied to phenylaminoquinazoline analogues. It is known that the substituents at the 6- and 7- positions of the polycyclic system have been identified as the most important structural features. The steric as well as the electrostatic interactions proved to be the most important for the inhibitory effect. In this contribution it is shown that the orientation of nodes in their occupied pi orbitals, and also the energies of these orbitals explains a further large portion of the variance in their inhibitory activity.
authors.affiliation: Faculty of Pharmacy, Al-Quds University, Jerusalem, Palestine. deeb2000il@yahoo.com
authors.forename: Omar
authors.initials: O
authors.lastname: Deeb
authors.forename: Brian W
authors.initials: BW
authors.lastname: Clare
mesh_terms: D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D021281:Quantitative Structure-Activity Relationship; D011799:Quinazolines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D066246:ErbB Receptors