title: Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties.
abstract: A new study on terphenyl and diaryl-isoxazole and -isoxazoline derivatives, maintaining a common 3-adamantyl-4-hydroxyphenyl moiety, has been conducted to find compounds with growth supporting and antiapoptotic properties. Unexpectedly, diphenyisoxazole derivatives bearing a nitro group replacing the carboxylic function have been found with the highest cell protective activity within the series, in complete and in serum-free conditions. Inhibition of apoptosis induced by daunorubicin has also been observed for the most active compound.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Ferrara, Italy. smd@unife.it
authors.forename: Daniele
authors.initials: D
authors.lastname: Simoni
authors.forename: Riccardo
authors.initials: R
authors.lastname: Rondanin
authors.forename: Riccardo
authors.initials: R
authors.lastname: Baruchello
authors.forename: Michele
authors.initials: M
authors.lastname: Rizzi
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Grisolia
authors.forename: Marco
authors.initials: M
authors.lastname: Eleopra
authors.forename: Stefania
authors.initials: S
authors.lastname: Grimaudo
authors.forename: Antonietta
authors.initials: A
authors.lastname: Di Cristina
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Pipitone
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Bongiorno
authors.forename: Mario
authors.initials: M
authors.lastname: Aricò
authors.forename: Francesco Paolo
authors.initials: FP
authors.lastname: Invidiata
authors.forename: Manlio
authors.initials: M
authors.lastname: Tolomeo
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013730:Terphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D007555:Isoxazoles; D013730:Terphenyl Compounds