Variation in the purinergic P2RX(7) receptor gene and schizophrenia.
BACKGROUND
The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia.


METHODS
Nine functionally characterised variants in P2RX(7) were genotyped in 389 patients diagnosed with schizophrenia, each matched on sex, birth-year and month with two healthy controls.


RESULTS
We did not find association between P2RX(7) and schizophrenia and stratification on gender did not change this result. The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding.


CONCLUSIONS
P2XR(7) was not associated with schizophrenia in this study.
Hansen
Thomas
T
Research Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen University Hospital, DK-4000 Roskilde, Denmark.
Jakobsen
Klaus D
KD
Fenger
Mogens
M
Nielsen
Jimmi
J
Krane
Karoline
K
Fink-Jensen
Anders
A
Lublin
Henrik
H
Ullum
Henrik
H
Timm
Sally
S
Wang
August G
AG
Jørgensen
Niklas Rye
NR
Werge
Thomas
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D003718:Denmark; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D018048:Receptors, Purinergic P2 / Q000235:genetics*; D058486:Receptors, Purinergic P2X7; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D044465:White People / Q000235:genetics; D055815:Young Adult
C546468:P2RX7 protein, human; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7