title: Calculation of R0 for age-of-infection models.
abstract: We consider age-of-infection epidemic models to describe multiple- stage epidemic models, including treatment. We derive an expression for the basic reproduction number R0 in terms of the distributions of periods of stay in the various compartments. We find that, in the model without treatment, R0 depends only on the mean periods in compartments, and not on the form of the distributions. In treatment models, R0 depends on the form of the distributions of stay in infective compartments from which members are removed for treatment, but the dependence for treatment compartments is only on the mean stay in the compartments. The results give a considerable simplification in the calculation of the basic reproduction number.
authors.affiliation: Harvard Graduate School of Education, Harvard University, Cambridge, MA 02138, USA. ckytina@alum.mit.edu
authors.forename: Christine K
authors.initials: CK
authors.lastname: Yang
authors.forename: Fred
authors.initials: F
authors.lastname: Brauer
mesh_terms: D017668:Age of Onset; D000465:Algorithms; D003141:Communicable Diseases / Q000453:epidemiology* / Q000635:transmission; D004196:Disease Outbreaks; D018450:Disease Progression; D018562:Disease Transmission, Infectious; D004813:Epidemiology; D006801:Humans; D007239:Infections / Q000453:epidemiology; D008433:Mathematics; D015233:Models, Statistical; D008962:Models, Theoretical; D013997:Time Factors