Correlation of 8-isoprostane, interleukin-6 and cardiac functions with clinical score in childhood obstructive sleep apnoea.
OBJECTIVE
Adeno-tonsillar hypertrophy is the commonest cause of childhood obstructive sleep apnoea (OSA). Our aim of the study is to correlate the severity of OSA with levels of 8-isoprostane and interleukin-6 (IL-6) and with cardiac diastolic dysfunctions.


METHODS
Forty children with adenoidal hypertrophy and 20 control children were recruited. The OSA clinical score was evaluated and IL-6 and 8-isoprostane were measured in exhaled breath condensate. The cardiac functions were evaluated by conventional and tissue Doppler echocardiography (TDE).


RESULTS
Higher concentrations of isoprostane-8 and IL-6 were found in group with clinical score >40 (58.595 +/- 2.86 pg/mL and 38 +/- 1.77 pg/mL, respectively) than in control group (34.9 +/- 1.5 pg/mL and 7.02 +/- 0.3 pg/mL, respectively) {p < 0.0001*}. There was positive correlation between level of isoprostane-8 and IL-6 and value of clinical score {p < 0.0001*} and also with the degree of the cardiac dysfunction in those children.


CONCLUSIONS
The severity of OSA as indicated by clinical score was positively correlated with degree of elevation of 8-Isoprostane and IL-6 in breath condensate of children with OSA and also with degree of cardiac dysfunction. Echocardiography and tissue Doppler modality are advised to examine these children.
Biltagi
Mohammed A
MA
Paediatric Department, Faculty of Medicine, Tanta University, Egypt. mbelrem@hotmail.com
Maguid
Mohammed A
MA
Ghafar
Mohammed A
MA
Farid
Eman
E
D000234:Adenoids / Q000473:pathology*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003971:Diastole; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D018384:Oxidative Stress; D010865:Pilot Projects; D017286:Polysomnography; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000209:etiology / Q000503:physiopathology*; D013599:Systole; D014463:Ultrasonography; D018754:Ventricular Dysfunction / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology
D015415:Biomarkers; D015850:Interleukin-6; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost