title: Papillary adenocarcinoma of the thymus: case report and review of the literature.
abstract: A 44-year-old male with a mediastinal mass measuring 3.5 × 3.5 × 3 cm was diagnosed with papillary adenocarcinoma of the thymus. Other origins of papillary adenocarcinoma were excluded by clinical, imaging, and immunocytochemical methods before assuming this diagnosis. Residual thymus was seen under the microscope. Focal CD5 immunoreactivity was present. There was no associated thymoma. The patient underwent surgery, radiotherapy, and chemotherapy. He disclosed systemic recurrence at 18 months (subcutaneous nodule). He is alive after 24 months of follow-up with active disease. There had been only 7 cases of this rare entity published before.
authors.affiliation: Anatomic Pathology Service, Vila Nova de Gaia-Espinho Medical Center, Portugal. antoniafurtado@gmail.com
authors.forename: Antónia
authors.initials: A
authors.lastname: Furtado
authors.forename: Rosete
authors.initials: R
authors.lastname: Nogueira
authors.forename: Diva
authors.initials: D
authors.lastname: Ferreira
authors.forename: David
authors.initials: D
authors.lastname: Tente
authors.forename: Rogério
authors.initials: R
authors.lastname: Eisele
authors.forename: Bárbara
authors.initials: B
authors.lastname: Parente
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D029481:Bronchitis, Chronic / Q000150:complications; D003131:Combined Modality Therapy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011878:Radiotherapy; D012907:Smoking; D013934:Thymectomy; D013953:Thymus Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents