title: Meta-analysis: narrow band imaging for lesion characterization in the colon, oesophagus, duodenal ampulla and lung.
abstract: BACKGROUND
  Narrow band imaging is a new endoscopic technology that highlights mucosal surface structures and microcapillaries, which may be indicative of neoplastic change.
  
  
  OBJECTIVE
  To assess the diagnostic precision of narrow band imaging for the diagnosis of epithelial neoplasia compared to conventional histology both overall and in specific organs.
  
  
  METHODS
  We performed a meta-analysis of studies which compared narow band imaging-based diagnosis of neoplasia with histopathology as the gold standard. Search terms: 'endoscopy' and 'narrow band imaging'.
  
  
  RESULTS
  Five hundred and eighty-two patients and 1108 lesions in 11 studies were included. Overall, sensitivity was 0.94 (95% confidence interval 0.92-0.95), specificity 0.83 (0.80-0.86); weighted area under the curve was 0.96 (standard error 0.02), diagnostic odds ratio (DOR) 72.74 (34.11-155.15). DORs were 66.65 (25.84-171.90), 61.19 (7.09-527.97), 69.74 (8.04-605.24) for colon, oesophagus and lung respectively. Studies with more than 50 patients had higher diagnostic precision, relative DOR 4.96 (1.28-19.27), P = 0.022. There was no difference in accuracy between microvessel and mucosal (pit) pattern based measures, relative DOR 1.29 (0.05-35.16), P = 0.87. There was significant heterogeneity overall between studies, Q = 31.2, P = 0.003.
  
  
  CONCLUSIONS
  Narrow band imaging is accurate with high diagnostic precision for in vivo diagnosis of neoplasia across a range of organs, using simple microvessel-based measures.
authors.affiliation: Wolfson Unit for Endoscopy, St. Mark's Hospital, Imperial College London, London. jameseast6@yahoo.com
authors.forename: J E
authors.initials: JE
authors.lastname: East
authors.forename: E K
authors.initials: EK
authors.lastname: Tan
authors.forename: J J
authors.initials: JJ
authors.lastname: Bergman
authors.forename: B P
authors.initials: BP
authors.lastname: Saunders
authors.forename: P P
authors.initials: PP
authors.lastname: Tekkis
mesh_terms: D019540:Area Under Curve; D003106:Colon / Q000473:pathology; D004386:Duodenum / Q000473:pathology; D004724:Endoscopy / Q000379:methods*; D004947:Esophagus / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000473:pathology; D009369:Neoplasms / Q000175:diagnosis*; D011230:Precancerous Conditions / Q000175:diagnosis; D012680:Sensitivity and Specificity