[Current views on the role of dehydroepiandrosterone in physiology, pathology and therapy].
Dehydroepiandrosterone (DHEA) and its sulfate metabolite (DHEAS) are the major androgens secreted by the human adrenal gland. The decline in their production is the most characteristic age-related change in the adrenal cortex. This process, known as 'adrenopause' may contribute to the increased incidence of atherosclerosis, cancer, or dementia in older people. The possibility of using DHEA in management has attracted considerable attention over recent years. Whereas DHEA therapy seems to be effective in treating patients with adrenal insufficiency and systemic lupus erythematosus, clinical studies investigating the potential efficacy of DHEA therapy in multiple other disorders (Alzheimer disease, depression, cardiovascular disease, osteoporosis, sexual dysfunctions) have not provided consistent results. Further research is also needed to better assess the efficacy and safety of DHEA supplementation in patients with advanced age. This review evaluates current understanding of physiology and pathology of DHEA production and summarizes the possible therapeutic value of this hormone.
Krysiak
Robert
R
Slaska Akademia Medyczna w Katowicach, Klinika Chorób Wewnetrznych i Farmakologii Klinicznej Katedry Farmakologii. r.krysiak@pharmanet.com.pl
Frysz-Naglak
Dorota
D
Okopień
Bogusław
B
D000307:Adrenal Gland Diseases / Q000188:drug therapy / Q000378:metabolism; D000311:Adrenal Glands / Q000378:metabolism*; D050499:Adrenarche / Q000502:physiology*; D000368:Aged; D000375:Aging / Q000378:metabolism*; D050197:Atherosclerosis / Q000378:metabolism / Q000517:prevention & control; D002319:Cardiovascular System / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000276:immunology / Q000378:metabolism* / Q000627:therapeutic use*; D003704:Dementia / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism
D011987:Receptors, Steroid; C095972:dehydroepiandrosterone receptor; D003687:Dehydroepiandrosterone