Activation of vocal fold healing with topical vitamin A in rabbits.
CONCLUSIONS
The results suggest that vitamin A can prevent scar formation in the vocal fold after surgery.


OBJECTIVE
This study aimed to evaluate the effects of topically applied vitamin A on healing after vocal fold trauma.


METHODS
Vocal folds of 20 adult rabbits were traumatized unilaterally. Ten of them were treated with topical application of vitamin A and the others served as controls. All animals were sacrificed after 10 days. Vocal folds were resected for analysis by light microscopy.


RESULTS
The untreated vocal folds showed extensive deposition of collagen and fibroblast on light microscopy and vocal folds treated with vitamin A showed less deposition. There was a significant difference between the two groups according to the percentage of collagen and fibroblasts in the lamina propria (p<0.01).
Akdogan
Ozgur
O
Ankara Numune Education and Research Hospital, 4th ENT Clinic, Attending Otolaryngolog Ankara, Ankara, Turkey. drozgurakdogan@gmail.com
Selcuk
Adin
A
Ozcan
Ibrahim
I
Ozcan
Kürsat Murat
KM
Giray
Seren Gulsen
SG
Dere
Huseyin
H
Ozogul
Candan
C
D000287:Administration, Topical; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002921:Cicatrix / Q000473:pathology / Q000517:prevention & control; D003094:Collagen / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D007820:Laryngeal Mucosa / Q000187:drug effects / Q000473:pathology; D007828:Laryngoscopy; D011817:Rabbits; D014212:Tretinoin / Q000494:pharmacology*; D014827:Vocal Cords / Q000187:drug effects* / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*
D014212:Tretinoin; D003094:Collagen