title: The prevalence of signs and symptoms of childhood leukemia and lymphoma in Fars Province, Southern Iran.
abstract: BACKGROUND
  Leukemia and lymphomas are still the common childhood cancers in Iran. This study was undertaken to determine the prevalence of signs and symptoms of these malignancies in children of Fars Province, Southern Iran.
  
  
  METHODS
  A total of 368 cases of children who were less than 15 years old and diagnosed as acute lymphocytic leukemia (ALL, n=211), acute myeloid leukemia (AML, n=64), Burkitt lymphoma (BL, n=40), chronic myeloid leukemia (CML, n=5), Hodgkin's disease (HD, n=33) or non-Burkitt-type, non-Hodgkin's lymphoma (NBNHL, n=15) referring to the hospitals of Shiraz University of Medical Sciences from April 1997 to March 2002 were enrolled. A questionnaire was provided to record the age, median age at the onset of the disease, sex, type of malignancy and the signs and symptoms at the time of presentation.
  
  
  RESULTS
  The common sign or symptoms were fever (74%), in ALL, AML, NHL, and BL patients, hepatosplenomegaly (100%) in CML patients, and lymphadenopathy (54%) and fever (54%) in Hodgkin's disease.
  
  
  CONCLUSIONS
  Knowledge of signs and symptoms and types of presentations of childhood leukemia and lymphoma may help a physician to improve the patient's outcome. This study revealed that attention to uncommon signs and symptoms in history taking and physical examination together with laboratory tests may increase the physicians' awareness and better diagnosis of pediatric malignancies and would also be beneficial for the patient.
authors.affiliation: Hemostasis and Thrombosis Research Unit, Hematology Research Center, Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Karimim@sums.ac.ir
authors.forename: Mehran
authors.initials: M
authors.lastname: Karimi
authors.forename: Davood
authors.initials: D
authors.lastname: Mehrabani
authors.forename: Hooman
authors.initials: H
authors.lastname: Yarmohammadi
authors.forename: Farideh Safaei
authors.initials: FS
authors.lastname: Jahromi
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D007938:Leukemia / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D008223:Lymphoma / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D015995:Prevalence