Lycopene suppresses ovalbumin-induced airway inflammation in a murine model of asthma.
In this study, we attempt to determine whether lycopene regulates inflammatory mediators in the ovalbumin (OVA)-induced murine asthma model. To address this, mice were sensitized and challenged with OVA, and then treated with lycopene before the last OVA challenge. Administration of lycopene significantly alleviated the OVA-induced airway hyperresponsiveness to inhaled methacholine. Administration of lycopene also resulted in a significant inhibition of the infiltration of inflammatory immunocytes into the bronchoalveolar lavage, and attenuated the gelatinolytic activity of matrix metalloproteinase-9 and the expression of eosinophil peroxidase. Additionally, lycopene reduced the increased levels of GATA-3 mRNA level and IL-4 expression in OVA-challenged mice. However, it increased T-bet mRNA level and IFN-gamma expression in lycopene-challenged mice. These findings provide new insight into the immunopharmacological role of lycopene in terms of its effects in a murine model of asthma.
Lee
Chang-Min
CM
Department of Microbiology and Immunology, Pusan National University College of Medicine, Busan 602-739, Republic of Korea.
Chang
Jeong-Hyun
JH
Moon
Dong-Oh
DO
Choi
Yung Hyun
YH
Choi
Il-Whan
IW
Park
Yeong-Min
YM
Kim
Gi-Young
GY
D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D001992:Bronchoalveolar Lavage Fluid; D002338:Carotenoids / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004804:Eosinophils / Q000187:drug effects / Q000276:immunology; D004921:Erythropoietin / Q000037:antagonists & inhibitors; D005260:Female; D050990:GATA3 Transcription Factor / Q000037:antagonists & inhibitors / Q000235:genetics; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors*; D015847:Interleukin-4 / Q000037:antagonists & inhibitors / Q000235:genetics; D000077276:Lycopene; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D020780:Matrix Metalloproteinase 9 / Q000235:genetics; D061965:Matrix Metalloproteinase Inhibitors; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010047:Ovalbumin / Q000276:immunology; D012333:RNA, Messenger / Q000037:antagonists & inhibitors
D050990:GATA3 Transcription Factor; C494748:Gata3 protein, mouse; D018836:Inflammation Mediators; D061965:Matrix Metalloproteinase Inhibitors; D012333:RNA, Messenger; D004921:Erythropoietin; D015847:Interleukin-4; D002338:Carotenoids; D010047:Ovalbumin; D020780:Matrix Metalloproteinase 9; D000077276:Lycopene