Fetal and neonatal Graves disease: a case report and review of the literature.
Fetal and neonatal thyrotoxicosis from maternal Graves disease is a very rare entity. Fetal symptoms result from the transplacental passage of thyroid-stimulating immunoglobulins, which persist in the neonate resulting in neonatal symptoms. We present a case of fetal and neonatal thyrotoxicosis from maternal Graves disease. Fetal symptoms were controlled with maternal administration of antithyroid drugs leading to fetal thyroid inhibition. We present this case with a brief review of the literature.
Aslam
Muhammad
M
Department of Pediatrics and Division of Newborn Medicine, Harvard Neonatal-Perinatal Fellowship Program, Children's Hospital Boston, Boston, MA, USA. muhammad.aslam@childrens.harvard.edu
Inayat
Musaddaq
M
D005260:Female; D005315:Fetal Diseases / Q000209:etiology*; D006111:Graves Disease / Q000209:etiology*; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000378:metabolism; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications; D055815:Young Adult
D018828:Immunoglobulins, Thyroid-Stimulating