Quantitative analysis of the ultrasonic vocalization responses elicited in adjuvant-induced arthritic rats for screening analgesic drugs.
Adjuvant-induced arthritic (AIA) rats have been developed as a chronic pain model to evaluate the effects of analgesic drugs. The purpose of the present study was to examine whether there is dose-dependent inhibition of the emission of ultrasonic vocalization (USV) responses by analgesic drugs in AIA rats. It was demonstrated that morphine (1.25-5.0 mg/kg, s.c.) and ketoprofen (2.5-10.0 mg/kg, s.c.) dose-dependently inhibit USV responses. These results suggest that the USV responses elicited in AIA rats are useful for the quantitative evaluation of analgesic drugs.
Naito
Hiroyuki
H
Department of Physiology , School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
Inoue
Maki
M
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D007660:Ketoprofen / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D014465:Ultrasonics; D014828:Vocalization, Animal / Q000187:drug effects / Q000502:physiology*
D000700:Analgesics; D009020:Morphine; D007660:Ketoprofen