Synthesis and characterization of a smart contrast agent sensitive to calcium.
A novel first-generation Ca2+ sensitive contrast agent, Gd-DOPTRA has been synthesized and characterized. The agent shows approximately 100% relaxivity enhancement upon addition of Ca2+. The agent is selective and sensitive to Ca2+ also in the presence of Mg2+ and Zn2+. The relaxivity studies carried out in physiological fluids prove the prospects of the agent for in vivo measurements.
Dhingra
Kirti
K
Max Planck Institute for Biological Cybernetics, Department of Physiology of Cognitive Processes, Tübingen, Germany. Kirti.Dhingra@tuebingen.mpg.de
Maier
Martin E
ME
Beyerlein
Michael
M
Angelovski
Goran
G
Logothetis
Nikos K
NK
D002118:Calcium / Q000737:chemistry*; D002555:Cerebrospinal Fluid / Q000737:chemistry; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015032:Zinc / Q000737:chemistry
D003287:Contrast Media; C531506:Gd-DOPTRA; D009942:Organometallic Compounds; D008274:Magnesium; D015032:Zinc; D002118:Calcium