Adipose-derived stem cells and their secretory factors as a promising therapy for skin aging.
BACKGROUND
Adipose-derived stem cells (ADSCs) and their secretory factors can stimulate collagen synthesis and migration of fibroblasts during the wound healing process. Conventional treatments for skin aging, such as lasers and topical regimens, induce new collagen synthesis via activation of dermal fibroblasts or growth factors. Considering the results of our previous study, ADSCs can also be used for the treatment of skin aging.


OBJECTIVE
The aim was to verify the effectiveness of ADSCs for the treatment of skin aging.


METHODS
We analyzed secretory factors of ADSCs and intradermally injected ADSCs (1 x 10(6) cells in 1 mL of Hanks' buffered salt solution) and conditioned media of ADSCs on the back of a micropig. In addition, as a pilot study, intradermal injections of purified autologous processed lipoaspirate (PLA) cells were tried with the photoaged skin of one patient.


RESULTS
We demonstrated that ADSCs produce many useful growth factors, increase collagen production in animal study, and reverse skin aging in human trial.


CONCLUSIONS
ADSCs and their secretory factors show promise for application in cosmetic dermatology, especially in the treatment of skin aging.
Park
Byung-Soon
BS
Division of Stem Cell Research, Prostemics Research Institute, Seoul, Korea.
Jang
Kyoung Ae
KA
Sung
Jong-Hyuk
JH
Park
Jeong-Soo
JS
Kwon
Yong Hyun
YH
Kim
Kea Jeong
KJ
Kim
Won-Serk
WS
D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D003357:Cosmetic Techniques; D006801:Humans; D007271:Injections, Intradermal; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis*; D023421:Models, Animal; D010865:Pilot Projects; D015595:Skin Aging; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000378:metabolism*; D013552:Swine; D014182:Transplantation, Autologous
D036341:Intercellular Signaling Peptides and Proteins; D003094:Collagen