title: Chorionic villus sampling and the risk of adverse outcome in patients undergoing multifetal pregnancy reduction.
abstract: OBJECTIVE
  The objective of the study was to determine whether patients undergoing chorionic villus sampling (CVS) prior to MPR are at increased risk for adverse outcome compared to those who did not.
  
  
  METHODS
  We retrospectively identified multifetal pregnancy reduction (MPR) patients from an established database. Maternal demographic data were collected. Outcomes including complete pregnancy loss prior to 24 weeks' gestation, gestational age at delivery, and birthweight were analyzed.
  
  
  RESULTS
  There was no significant difference in pregnancy loss between the 2 groups (CVS [4%] vs no CVS [7%], P = .098). When stratified by finishing number, there was a significantly lower loss rate in the singleton CVS group (2% vs 9%, P = .025) and no significant difference in reduced twins. There was no significant difference in the average gestational age of delivery or birthweight.
  
  
  CONCLUSIONS
  CVS prior to MPR does not increase the risk of pregnancy loss. Our data suggest that CVS prior to singleton reduction may decrease the risk of adverse outcome.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY 10029, USA. lauren.ferrara@mssm.edu
authors.forename: Lauren
authors.initials: L
authors.lastname: Ferrara
authors.forename: Manisha
authors.initials: M
authors.lastname: Gandhi
authors.forename: Christian
authors.initials: C
authors.lastname: Litton
authors.forename: E Clair
authors.initials: EC
authors.lastname: McClung
authors.forename: Katherine
authors.initials: K
authors.lastname: Jandl
authors.forename: Erin
authors.initials: E
authors.lastname: Moshier
authors.forename: Keith
authors.initials: K
authors.lastname: Eddleman
authors.forename: Joanne
authors.initials: J
authors.lastname: Stone
mesh_terms: D000328:Adult; D001724:Birth Weight; D015193:Chorionic Villi Sampling; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D018607:Pregnancy Reduction, Multifetal; D012189:Retrospective Studies