title: mlegp: statistical analysis for computer models of biological systems using R.
abstract: Gaussian processes (GPs) are flexible statistical models commonly used for predicting output from complex computer codes. As such, GPs are well suited for the analysis of computer models of biological systems, which have been traditionally difficult to analyze due to their high-dimensional, non-linear and resource-intensive nature. We describe an R package, mlegp, that fits GPs to computer model outputs and performs sensitivity analysis to identify and characterize the effects of important model inputs.
  
  
  BACKGROUND
  http://www.biomath.org/mlegp
authors.affiliation: Program in Bioinformatics & Computational Biology, Department of Statistics and Department of Genetics, Development & Cell Biology, Iowa State University, Ames, IA 50010, USA.
authors.forename: Garrett M
authors.initials: GM
authors.lastname: Dancik
authors.forename: Karin S
authors.initials: KS
authors.lastname: Dorman
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D008954:Models, Biological; D015233:Models, Statistical; D016011:Normal Distribution; D011381:Programming Languages; D012984:Software