Nicotinamide adenine dinucleotide phosphate oxidase and diabetes: vascular implications.
Vascular disease associated with diabetes mellitus is a major cause of morbidity and mortality and is increasing in the United States. It is now recognized that oxidative stress plays a substantial role in the underlying vascular pathology of several diseases, including hypertension and diabetes. In diabetes, there is an increase in the steady state levels of reactive oxygen species. One of the primary generators of reactive oxygen species is nicotinamide adenine dinucleotide phosphate oxidase. Studies have indicated that inhibition of this system is associated with vascular benefits in diabetes. Therefore, there may be a role for therapies directed at nicotinamide adenine dinucleotide phosphate oxidase in this disease. This review will examine the structure, activation, potential role in vascular disease, and benefits of inhibition of nicotinamide adenine dinucleotide phosphate oxidase.
Maier
Kristopher G
KG
Upstate Medical University College of Medicine, Syracuse, New York 13210, USA. maierk@upstate.edu
D000975:Antioxidants / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000201:enzymology*; D003925:Diabetic Angiopathies / Q000188:drug therapy / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D019255:NADPH Oxidases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D011487:Protein Conformation; D017382:Reactive Oxygen Species / Q000378:metabolism; D013329:Structure-Activity Relationship
D000975:Antioxidants; D004791:Enzyme Inhibitors; D017382:Reactive Oxygen Species; D019255:NADPH Oxidases