[The relation between reg 1A mRNA expression and the clinicopathologic parameters in the patients with primary gastric carcinoma].
Using reverse transcriptase-polymerase chain reaction (RT-PCR), REG 1A mRNA expression was investigated in 235 primary gastric carcinoma samples. And the relation between these results with the clinicopathologic parameters of primary gastric carcinoma was discussed in experiment. The positive REG 1A mRNA is 78% (183/235) of primary gastric carcinoma which revealed by RT-PCR analysis. Moreover, patients with REG 1A-positive differentiated adenocarcinoma were found to have a significantly poorer prognosis compared with REG 1A-negative tumor patients. REG IA mRNA is closely linked to the infiltrative growth pattern and with signet ring cell carcinoma and poorly differentitated adencarcinoma. And the incidence of venous invasion of REG 1A-positive tumors was significantly higher than that of REG 1A-negative tumors. So the results of the experiment demonstrate that the expression of the REG 1A gene is closely related to the infiltrating property of primary gastric carcinoma, and may be as a prognostic indicator of differentiated adenocarcinoma of the stomach in clinic diagnosis.
Liu
Xiao Guang
XG
College of Medicine, Zhejiang University, Hangzhou.
Yang
Yue Qin
YQ
Fang
Xiang Ming
XM
Li
Ji Cheng
JC
D000328:Adult; D014408:Biomarkers, Tumor / Q000235:genetics; D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051847:Lithostathine / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D013534:Survival
D014408:Biomarkers, Tumor; D051847:Lithostathine; C497617:REG1A protein, human