title: Outcomes of preterm premature rupture of membranes in twin pregnancies.
abstract: OBJECTIVE
  To describe outcomes in twin pregnancies with preterm premature rupture of membranes (PPROM).
  
  
  METHODS
  Dichorionic twin pregnancies complicated by PPROM at <34 weeks of gestation for the period 2003 to 2006 were identified. Outcomes were obtained through chart review. The relationship between gestational age at premature rupture of membranes (PROM), latency from PROM to delivery, and infection were examined.
  
  
  RESULTS
  In 49 twin pregnancies, the median gestational age at PROM was 31 weeks with a median latency between PROM and delivery of 0 days (interquartile range 0-6). Latency intervals of >or=2 and >or=7 days were achieved by 40.8% and 22.4%, respectively. PPROM at <30 weeks was associated with significantly higher rates of latency of >or= 2 days (70.6% vs. 25.0%) and >or=7 days (47.1% vs. 9.4%). There was a significant relationship between latency and clinical and histologic signs of infection.
  
  
  CONCLUSIONS
  After 30 weeks, most twin pregnancies with PPROM delivered within 2 days. Infection appears to be a consequence rather than a cause of PPROM in most cases.
authors.affiliation: Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA.
authors.forename: Stephanie V
authors.initials: SV
authors.lastname: Trentacoste
authors.forename: Claudel
authors.initials: C
authors.lastname: Jean-Pierre
authors.forename: Rebecca
authors.initials: R
authors.lastname: Baergen
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Chasen
mesh_terms: D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000209:etiology / Q000401:mortality; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple / Q000502:physiology; D047928:Premature Birth / Q000175:diagnosis / Q000209:etiology / Q000401:mortality; D012189:Retrospective Studies; D014429:Twins, Dizygotic