Stereotactic body radiotherapy in the management of painful bone metastases.
More than 100,000 new cases of bone metastases are diagnosed each year, and they present an important clinical problem. They cause significant morbidity and quality-of-life issues in cancer patients. Conventional external-beam radiotherapy is currently the most common method to treat these metastases, with several randomized controlled trials showing no difference in effectiveness between multiple- and single-dosing treatment regimens. A newer technology to treat bone metastases is stereotactic body radiotherapy (SBRT), a radiation delivery method that allows for a large ablative dose to be accurately given to the target over one to a few fractions. This review details the role of SBRT in painful bone metastases, primarily in the vertebral column, but in other bony sites as well, its unique advantages and disadvantages, and its role in the treatment of tumors traditionally deemed radioresistant. Toxicity to surrounding normal tissues and patterns of local failures are also addressed.
Jhaveri
Pavan
P
Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA.
Teh
Bin S
BS
Bloch
Charles
C
Amato
Robert
R
Butler
E Brian
EB
Paulino
Arnold C
AC
D001859:Bone Neoplasms / Q000150:complications / Q000532:radiotherapy* / Q000556:secondary*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D010146:Pain / Q000209:etiology*; D010166:Palliative Care / Q000379:methods; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods