Lack of vertical transmission of Hantaan virus from persistently infected dam to progeny in laboratory mice.
It is unclear how the hantaviruses are transferred from infected to uninfected rodents. We studied the status of persistently infected laboratory mice and examined the frequency of viral transmission to their offspring. Expression of Hantaan virus nucleocapsid protein was detected in the lungs of persistently infected dams. None of the progeny displayed viral antigen, although they were strongly positive for IgG antibodies against hantavirus. There was neither hantavirus RNA nor virus-specific IgM antibodies or virus-specific CD8(+) T cells in the progeny. These results did not show any indication for a vertical transmission of hantaviruses, at least in the laboratory mouse model studied.
Taruishi
Midori
M
Institute for Animal Experimentation, Hokkaido University Graduate School of Medicine, Kita-ku, Kita-15, Nishi-7, Sapporo, Japan.
Yoshimatsu
Kumiko
K
Hatsuse
Rei
R
Okumura
Megumi
M
Nakamura
Ichiro
I
Arikawa
Jiro
J
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D036022:Capsid Proteins / Q000276:immunology*; D005260:Female; D018063:Hantaan virus / Q000276:immunology*; D018804:Hantavirus Pulmonary Syndrome / Q000635:transmission* / Q000821:virology; D018445:Infectious Disease Transmission, Vertical; D008168:Lung; D051379:Mice; D023421:Models, Animal; D011247:Pregnancy / Q000276:immunology; D014758:Viral Core Proteins / Q000276:immunology*
D036022:Capsid Proteins; D014758:Viral Core Proteins; C111782:nucleocapsid protein, Hantaan virus