Alpha particle vascular brachytherapy in the treatment of in-stent Restenosis.
In-stent Restenosis (ISR) is the Achilles heel for using of stent. Vascular brachytherapy (VBT) has been the principal scientifically investigated local therapy for coronary artery ISR. In our suggested method, a new type of stent, which is coated with Boron ((10)B) compound, is used. The coating layer of the stent consists of stable isotype of (10)B. Boron Neutron Capture Therapy produced alpha particle has enough energy to kill the cells adjacent to the stent, which is the site of boron deposition. It would prevent from ISR and intimal proliferation. After percutaneous coronary intervention (PCI) and insertion of stent, follow-up should be done continuously, and if ISR is detected, BNCT will be used to treat the recurrence. Using this modality of VBT would help us to overcome the pitfalls in en vogue radiotherapy methods.
Mehdizadeh
Alireza
A
Fazelzadeh
Afsoon
A
Karimi
Hamed
H
D000512:Alpha Particles; D015906:Angioplasty, Balloon, Coronary; D016754:Boron Neutron Capture Therapy; D001918:Brachytherapy / Q000379:methods*; D003324:Coronary Artery Disease / Q000628:therapy*; D023903:Coronary Restenosis / Q000532:radiotherapy*; D006801:Humans; D015607:Stents