No association between systemic sclerosis and C77G polymorphism in the human PTPRC (CD45) gene.
OBJECTIVE
The functional variant C77G (rs17612648) of PTPRC (CD45) was described to confer risk for systemic sclerosis (SSc) in German Caucasians. We analyzed this association in an independent, larger German cohort.


METHODS
We genotyped 171 cases and 179 controls. Cases were subgrouped according to sex, autoantibody profiles, or clinical subsets.


RESULTS
No association of SSc with C77G was detected in the whole dataset, in subgroups, or in combined analyses with a previous study.


CONCLUSIONS
The results do not confirm PTPRC C77G as a general and independent risk factor for development of SSc.
Kirsten
Holger
H
Institute of Clinical Immunology and Transfusion Medicine,University of Leipzig, Leipzig, Germany.
Blume
Mechthild
M
Emmrich
Frank
F
Hunzelmann
Nico
N
Mierau
Rudolf
R
Rzepka
Rita
R
Vaith
Peter
P
Witte
Torsten
T
Melchers
Inga
I
Ahnert
Peter
P
D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005858:Germany; D006801:Humans; D017493:Leukocyte Common Antigens / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000097:blood / Q000235:genetics*; D044465:White People / Q000235:genetics
D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human