title: The use of solid lipid nanoparticles to target a lipophilic molecule to the liver after intravenous administration to mice.
abstract: Taspine solid lipid nanoparticles (Ta-SLN) and taspine solid lipid nanoparticles modified by galactoside (Ta-G2SLN) were prepared by the film evaporation-extrusion method. The nanoparticles were spherical or near-spherical particles with smooth surface, small size and high encapsulation efficiency. Ta-G2SLN and Ta-SLN showed significant inhibition on 7721 cell growth. Intravenous injection of either Ta-SLN or Ta-G2SLN resulted in a higher plasma and liver concentration and a longer retention time in mice compared with the administration of Ta. These results suggested that SLN tended to be preferentially delivered to the liver and Ta-G2SLN may further enhance liver targeting.
authors.affiliation: School of Medicine, Xi'an Jiaotong University, No. 76 Western Yanta Road, Xi'an 710061, PR China.
authors.forename: Wen
authors.initials: W
authors.lastname: Lu
authors.forename: Lang Chong
authors.initials: LC
authors.lastname: He
authors.forename: Chang He
authors.initials: CH
authors.lastname: Wang
authors.forename: Yan Hua
authors.initials: YH
authors.lastname: Li
authors.forename: San Qi
authors.initials: SQ
authors.lastname: Zhang
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage* / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D005697:Galactosides / Q000737:chemistry; D007275:Injections, Intravenous; D008055:Lipids / Q000737:chemistry*; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D004337:Drug Carriers; D005697:Galactosides; D008055:Lipids; C018394:taspine