Familial myeloma.
We describe a family with five cases of multiple myeloma, three cases of monoclonal gammopathy of undetermined significance (MGUS), and five cases of prostate cancer in two generations. The putative progenitor had progeny with two female partners. The progeny had prostate cancer, multiple myeloma, and MGUS.
Lynch
Henry T
HT
Creighton University School of Medicine, Omaha, USA.
Ferrara
Kelly
K
Barlogie
Bart
B
Coleman
Elizabeth A
EA
Lynch
Jane F
JF
Weisenburger
Dennis
D
Sanger
Warren
W
Watson
Patrice
P
Nipper
Henry
H
Witt
Vinetta
V
Thomé
Stephan
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044383:Black People / Q000235:genetics; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000097:blood; D007146:Immunoglobulin lambda-Chains / Q000097:blood; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics*; D009386:Neoplastic Syndromes, Hereditary; D010265:Paraproteinemias / Q000097:blood / Q000235:genetics* / Q000276:immunology; D010375:Pedigree; D011471:Prostatic Neoplasms / Q000235:genetics*
D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains