A structural constitutive model for the human lens capsule.
Published data on the mechanical performance of the human lens capsule when tested under uniaxial and biaxial conditions are reviewed. It is concluded that two simple phenomenological constitutive models (namely a linear elastic model and a Fung-type hyperelastic model) are unable to provide satisfactory representations of the mechanical behaviour of the capsule for both of these loading conditions. The possibility of resolving these difficulties using a structural constitutive model for the capsule, of a form that is inspired by the network of collagen IV filaments that exist within the lens capsule, is explored. The model is implemented within a rectangular periodic cell. Prescribed stretches are imposed on the periodic cell and the network is allowed to deform in a non-affine manner. The performance of the constitutive model correlates well with previously published test data. One possible application of the model is in the development of a multi-scale analysis of the mechanics of the human lens capsule.
Burd
Harvey John
HJ
Department of Engineering Science, Oxford University, Oxford, OX1 3PJ, UK. harvey.burd@eng.ox.ac.uk
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena; D003094:Collagen / Q000648:ultrastructure; D003198:Computer Simulation; D055119:Elastic Modulus; D020342:Finite Element Analysis; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000502:physiology* / Q000648:ultrastructure; D008875:Middle Aged; D008954:Models, Biological; D011312:Pressure
D003094:Collagen