Cholesterol lowering, sudden cardiac death and mortality.
Sudden cardiac death is the main cause of cardiac mortality. Is blood cholesterol a determinant of sudden cardiac death? Does cholesterol lowering result in fewer sudden cardiac deaths? Answering these two questions may shed a new light on the epidemiology of coronary heart disease and on prevention options. In fact, careful analysis of the available data, including randomised trials, indicates that, contrary to a widespread opinion, cholesterol lowering does not appear to be a very effective way of reducing cardiac and overall mortality in the general population.
de Lorgeril
Michel
M
Laboratoire TIMC IMAG CNRS UMR 5525, Groupe PRETA Coeur et Nutrition, Faculté de Médecine, La Tronche (Grenoble), France.
Salen
Patricia
P
D000924:Anticholesteremic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood*; D003327:Coronary Disease / Q000188:drug therapy / Q000401:mortality* / Q000517:prevention & control*; D016757:Death, Sudden, Cardiac / Q000517:prevention & control*; D006801:Humans; D012307:Risk Factors; D016896:Treatment Outcome
D000924:Anticholesteremic Agents; D002784:Cholesterol