Biotin-rich intranuclear inclusions: have you checked your immunohistochemical controls?
Intranuclear biotin interacts with avidin-biotin-complex used for viral immunoperoxidase detection giving false-positive results.
Bakkar
Rania
R
Department of Pathology and Laboratory Medicine, University of Louisville Hospital, Louisville, Kentucky, USA.
Moore
Grace
G
Martin
Alvin
A
Alatassi
Houda
H
D000328:Adult; D001710:Biotin / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism / Q000473:pathology*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D045586:Intranuclear Inclusion Bodies / Q000378:metabolism* / Q000473:pathology; D008297:Male; D010920:Placenta / Q000378:metabolism / Q000473:pathology*; D011247:Pregnancy
D001710:Biotin