title: A transmembrane polymorphism in FcgammaRIIb (FCGR2B) is associated with the production of anti-cyclic citrullinated peptide autoantibodies in Taiwanese RA.
abstract: The aim of the current study was to determine whether the FcgammaRIIb 187-Ile/Thr polymorphism is a predisposition factor for subtypes of RA defined by disease severity and production of autoantibodies against cyclic citrullinated peptides (anti-CCPs) in Taiwanese RA patients. Genotype distributions and allele frequencies of FcgammaRIIb 187-Ile/Thr were compared between 562 normal healthy controls and 640 RA patients as stratified by clinical parameters and autoantibodies. Significant enrichment of 187-Ile allele was observed in RA patients positive for anti-CCP antibodies as compared with the anti-CCP negative RA patients (P=0.001, OR 1.652 (95% CI 1.210-2.257)) or as compared with the normal controls (P=0.005, OR 1.348 (95% CI 1.092-1.664)). In addition, 187-Ile allele was found to be enriched in RA patients positive for rheumatoid factor (RF) compared to the RF negative RA patients (P=0.024, OR 1.562 (95% CI 1.059-2.303)). Furthermore, the homozygotes were enriched in destructive male RA patients (P=0.035; OR 2.038 (95% CI 1.046-3.973)) and the 187-Ile allele was associated with early-onset of RA in Taiwanese patients (P=0.045, OR 1.548 (95% CI 1.007-2.379)). Thus, FcgammaRIIb SNP 187-Ile/Thr may influence the RA phenotypes in Taiwanese RA.
authors.affiliation: Division of Allergy, Immunology and Rheumatology, Department of Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan, Taiwan, Republic of China. jychen31@adm.cgmh.org.tw
authors.forename: J-Y
authors.initials: JY
authors.lastname: Chen
authors.forename: C-M
authors.initials: CM
authors.lastname: Wang
authors.forename: C-C
authors.initials: CC
authors.lastname: Ma
authors.forename: L-A
authors.initials: LA
authors.lastname: Hsu
authors.forename: H-H
authors.initials: HH
authors.lastname: Ho
authors.forename: Y-J J
authors.initials: YJ
authors.lastname: Wu
authors.forename: S-N
authors.initials: SN
authors.lastname: Kuo
authors.forename: J
authors.initials: J
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000235:genetics*; D002648:Child; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000235:genetics / Q000276:immunology; D017452:Receptors, IgG / Q000235:genetics* / Q000276:immunology; D012217:Rheumatoid Factor / Q000235:genetics* / Q000276:immunology; D012737:Sex Factors; D013624:Taiwan; D055815:Young Adult
chemical_list: D001323:Autoantibodies; C499173:FCGR2B protein, human; D010456:Peptides, Cyclic; D017452:Receptors, IgG; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor