Primary intraocular lymphoma: another great masquerader.
OBJECTIVE
To describe diverse and atypical presentations of the most common masquerader in neoplastic masquerade syndromes.


METHODS
Retrospective interventional case series. The authors identified three patients who presented with atypical and diagnostically challenging masquerading manifestations. These patients were eventually found to have primary intraocular lymphoma (PIOL). Their case histories, presenting signs and symptoms, diagnostic tests, and treatments are described.


RESULTS
Patient 1 masqueraded as viral retinitis and branch retinal vein occlusion but was resistant to 5 weeks of oral and intravenous acyclovir. Patient 2 presented with choroidal infiltrates and vision loss. This patient had had breast carcinoma for the last 25 years and secondary metastasis was suspected. Patient 3 had chronic uveo-retinitis and a chronic Propionibacterium acnes infection was suspected. All three patients were diagnosed with PIOL.


CONCLUSIONS
PIOL is an aggressive masquerader and not only presents clinical diagnostic difficulties but also requires expert tissue handling and analysis, so that early diagnosis can be made and therapy can be instituted.
Gallagher
M J
MJ
Massachusetts Eye Research and Surgery Institution, Cambridge, MA 02142, USA.
Cervantes-Castañeda
R A
RA
Bhat
P
P
Yilmaz
T
T
Foster
C S
CS
D015862:Choroid Diseases / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D005451:Fluorescein Angiography; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D019572:Retinal Neoplasms / Q000175:diagnosis*; D012170:Retinal Vein Occlusion / Q000175:diagnosis*; D012173:Retinitis / Q000175:diagnosis*; D012189:Retrospective Studies; D014605:Uveitis / Q000175:diagnosis*
D007143:Immunoglobulin Heavy Chains