title: The effects of ACTH, phytoestrogens and estrogens on corticosterone secretion by gander adrenocortical cells in breeding and nonbreeding seasons.
abstract: The aim of this study was to investigate the effects of ACTH, phytoestrogens (genistein, daidzein, biochanin A and coumestrol), and animal estrogens (estradiol and estrone) on corticosterone secretion by isolated adrenocortical cells of the ganders in breeding (April) and nonbreeding seasons (July). ACTH stimulated corticosterone output in the breeding season. In July (photorefractoriness and postbreeding molt) ACTH had no effect on corticosterone production. Coumestrol reduced corticosterone secretion by the cells obtained in nonbreeding season. Other examined phytoestrogens did not affect corticosterone production. Estrogens showed differentiated effects. Estradiol stimulated the corticosterone output in breeding season; estrone inhibited corticosterone release in July. The season can probably affect sensitivity of isolated gander adrenal cells, especially to ACTH. It seems that goose adrenocortical cells, in contrast to the mammalian cells, can be weakly sensitive to phytoestrogens.
authors.affiliation: Department of Animal Physiology, Faculty of Biology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland. tkam@uwm.edu.pl
authors.forename: Barbara
authors.initials: B
authors.lastname: Kaminska
authors.forename: M
authors.initials: M
authors.lastname: Opalka
authors.forename: L
authors.initials: L
authors.lastname: Dusza
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001947:Breeding; D003345:Corticosterone / Q000378:metabolism*; D004967:Estrogens / Q000494:pharmacology*; D005777:Geese; D008297:Male; D048789:Phytoestrogens / Q000494:pharmacology*; D012621:Seasons
chemical_list: D004967:Estrogens; D048789:Phytoestrogens; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone