Subversion of cell cycle regulatory pathways.
Human cytomegalovirus (HCMV) has evolved numerous strategies to commandeer the host cell for producing viral progeny. The virus manipulates host cell cycle pathways from the early stages of infection to stimulate viral DNA replication at the expense of cellular DNA synthesis. At the same time, cell cycle checkpoints are by-passed, preventing apoptosis and allowing sufficient time for the assembly of infectious virus.
Sanchez
V
V
Deaprtment of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center, College Station, TX 77843-1266, USA.
Spector
D H
DH
D002453:Cell Cycle; D003587:Cytomegalovirus / Q000502:physiology*; D006801:Humans; D014779:Virus Replication