Protein kinase Cepsilon: the mitochondria-mediated signaling pathway.
Mitochondria, which are the cellular energy plants, also act as the integration center of cellular signaling pathways. Apoptosis is a well-known pathway in which mitochondria are involved. Protein kinase Cepsilon has been classified as a novel type of protein kinase C and is involved in many cellular events regulating mitochondrial function. Much evidence has accumulated regarding the relationships between mitochondria-mediated apoptosis and protein kinase Cepsilon. Therefore, by focusing on these relationships, in particular the anti-apoptotic effects of protein kinase Cepsilon on mitochondrial function, we highlight the importance and significance of protein kinase Cepsilon in cell survival and death.
Yonekawa
Hiromichi
H
Department of Laboratory Animal Science, The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan. yonekawa-hr@igakuken.or.jp <yonekawa-hr@igakuken.or.jp>
Akita
Yoshiko
Y
D000818:Animals; D017209:Apoptosis; D002308:Cardiolipins / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000201:enzymology* / Q000378:metabolism / Q000648:ultrastructure; D051744:Protein Kinase C-epsilon / Q000502:physiology*; D015398:Signal Transduction
D002308:Cardiolipins; D051744:Protein Kinase C-epsilon