The activity 'in vitro' of trospectomycin against high-level antibiotic-resistant enterococci.
Trospectomycin, a new aminocyclitol antibiotic, was uniformly active against 69 isolates of enterococci with high-level resistance to steptomycin (54 isolates), gentamicin (27 isolates), ampicillin (19 isolates), ciprofloxacin (17 isolates), vancomycin (3 isolates), or teicoplanin (3 isolates). In time-killing studies, trospectomycin alone demonstrated no bactericidal activity. No synergistic interaction was demonstrated when trospectomycin was combined with ampicillin, vacomycin or ciprofloxacin.
Venditti
M
M
Servizio Aggregato di Consulenze Infettivologiche, Istituto di Clinica, Medica VI, Universita La Sapienza, Rome, Italy.
Tarasi
A
A
Baiocchi
P
P
Lamonaca
V
V
Testore
G P
GP