title: The concentration of sparfloxacin in lung tissues after single and multiple oral doses.
abstract: The levels of sparfloxacin were measured in serum, alveolar macrophages, epithelial lining fluid (ELF) and bronchial mucosa after single and multiple oral doses. Measurement was performed using a microbiological assay technique. There were 21 subjects in the single dose and 10 subjects in the multiple dose groups. Following a single 400 mg dose of sparfloxacin the mean levels after 11-15 h were 1.2 mg/l in serum, 61.3 mg/l in macrophages, 9.8 mg/l in ELF and 2.6 mg/kg in mucosa. After multiple dosing of 400 mg on day 1 followed by 200 mg daily for the next 2 days the mean levels were 1.2 mg/l in serum, 53.7 mg/l in macrophages, 15.0 mg/l in ELF and 4.4 mg/kg in mucosa. These data predict good clinical efficacy in respiratory tract infections.
authors.affiliation: Department of Thoracic Medicine, Dudley Road Hospital, Birmingham B18 7QH, UK.
authors.forename: D
authors.initials: D
authors.lastname: Honeybourne
authors.forename: I
authors.initials: I
authors.lastname: Greaves
authors.forename: D R
authors.initials: DR
authors.lastname: Baldwin
authors.forename: J M
authors.initials: JM
authors.lastname: Andrews
authors.forename: M
authors.initials: M
authors.lastname: Harris
authors.forename: R
authors.initials: R
authors.lastname: Wise