Emotion-induced retrograde amnesia is determined by a 5-HTT genetic polymorphism.
A polymorphism in the human serotonin transporter (5-HTT) gene is implicated in susceptibility to anxiety and depression and in enhanced emotion-induced activation in the amygdala. A role for 5-HTT polymorphism in the emotional modulation of human episodic memory has yet to be demonstrated. Here, we demonstrate that whereas emotional memory for aversive events per se is not influenced by 5-HTT polymorphism, an emotion-induced retrograde amnesia is expressed solely in the presence of the short allele. The findings indicate a critical role for the serotonin system in emotion-mediated memory disruption.
Strange
Bryan A
BA
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, London WC1N 3BG, United Kingdom. bstrange@fil.ion.ucl.ac.uk
Kroes
Marijn C W
MC
Roiser
Jonathan P
JP
Tan
Geoffrey C Y
GC
Dolan
Raymond J
RJ
D000328:Adult; D000648:Amnesia, Retrograde / Q000209:etiology* / Q000235:genetics*; D000704:Analysis of Variance; D016022:Case-Control Studies; D004644:Emotions; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins