title: Kounis syndrome secondary to amoxicillin/clavulanic acid use in a child.
abstract: The concurrence of acute coronary syndromes with allergic or hypersensitivity as well as with anaphylactic or anaphylactoid reactions is increasingly encountered in clinical practice and there are several reports associating mast cell activation with acute cardiovascular events in adults. It was first described by Kounis as "allergic angina syndrome" progressing to "allergic myocardial infarction". The main mechanism proposed is the vasospasm of coronary arteries. This condition has not been described in childhood. We present a 13-year-old boy, admitted to our hospital with thoracic pain, 30 min after the ingestion of an oral dose of 500 mg of amoxicillin/clavulanic acid.
authors.forename: Murat
authors.initials: M
authors.lastname: Biteker
authors.forename: Nilüfer Ekşi
authors.initials: NE
authors.lastname: Duran
authors.forename: Funda Sungur
authors.initials: FS
authors.lastname: Biteker
authors.forename: Emre
authors.initials: E
authors.lastname: Ertürk
authors.forename: Ahmet Cağri
authors.initials: AC
authors.lastname: Aykan
authors.forename: Hasret Ayyildiz
authors.initials: HA
authors.lastname: Civan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozkan
mesh_terms: D054058:Acute Coronary Syndrome / Q000139:chemically induced / Q000175:diagnosis* / Q000503:physiopathology; D000293:Adolescent; D000658:Amoxicillin / Q000008:administration & dosage / Q000009:adverse effects*; D019818:Clavulanic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D004452:Echocardiography; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D019818:Clavulanic Acid; D000658:Amoxicillin