title: New MCR-Heck-isomerization cascade toward indoles.
abstract: The use of ortho-iodonitrophenol in Ugi-Smiles reaction coupled with Heck cyclization gives new access to indole scaffolds. The sequence can be performed in a one-pot reaction if the residual isocyanide is neutralized prior to the addition of the palladium catalyst.
authors.affiliation: Laboratoire Chimie et Procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris Cedex 15, France. laurent.elkaim@ensta.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: El Kaim
authors.forename: Marion
authors.initials: M
authors.lastname: Gizzi
authors.forename: Laurence
authors.initials: L
authors.lastname: Grimaud
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D009596:Nitrophenols / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D009570:Nitriles; D009596:Nitrophenols; D010165:Palladium