Angiotensinogen M235T polymorphism and symptoms of depression in a population-based study and a family-based study.
BACKGROUND
Evidence suggests that the angiotensinogen (AGT) gene is involved in depression. The aim of this paper is to examine the association between the AGT M235T polymorphism and symptoms of depression in two independent populations; a population-based study, and a family-based study.


METHODS
Symptoms of depression were scored using the Centre of Epidemiological Studies Depression Scale (CES-D) and compared between the MM, MT, and TT genotype groups. The extent to which AGT M235T explains the heritability of the scores was examined using a variance components analysis.


RESULTS
A significant relationship between the AGT M235T polymorphism and CES-D scores was found in men in both populations. The heritability estimate was 32%. The AGT genotype contributed to 1% of the total variance of the CES-D scores.


CONCLUSIONS
Our findings suggest that the AGT gene is involved in the aetiology of symptoms of depression in men.
López-León
Sandra
S
Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Janssens
A Cecile J W
AC
Tiemeier
Henning
H
Hofman
Albert
A
Aulchenko
Yurii S
YS
Snijders
Pieter J L M
PJ
Claes
Stephan
S
Oostra
Ben A
BA
van Duijn
Cornelia M
CM
D000368:Aged; D000375:Aging / Q000187:drug effects; D019943:Amino Acid Substitution; D000808:Angiotensinogen / Q000235:genetics*; D000959:Antihypertensive Agents / Q000494:pharmacology; D003863:Depression / Q000235:genetics*; D005190:Family; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D013912:Threonine / Q000235:genetics
D000959:Antihypertensive Agents; D000808:Angiotensinogen; D013912:Threonine; D008715:Methionine