title: Re-epithelialization after laser therapy of a stenotic artificial tracheal graft: a pilot experimental study.
abstract: Tracheal reconstruction is a challenging field of research for thoracic surgeons. Recent tracheal grafting studies report short observation times, which make it difficult to conclusively evaluate efficacy. Long-term studies examining the durability of artificial trachea strategies are needed. An ideal artificial trachea strategy would allow for no intervention following replacement, but this approach is presently infeasible. Today, interventional bronchoscopic techniques are widely accepted as a follow-up to airway problems after surgery. Our laboratory developed a semiconductor laser method for endobronchial treatment of stenotic implanted artificial trachea grafts. We herein report the results of a pilot study testing the endobronchial laser treatment in a canine model. The laser treatment yielded vigorous airway re-epithelialization on the graft from the native trachea.
authors.affiliation: Department of Surgery, Division of Chest Surgery, St Marianna University School of Medicine, Miyamae, Kawasaki, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tsukada
authors.forename: Hajime
authors.initials: H
authors.lastname: Inoue
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Osada
mesh_terms: D000818:Animals; D001999:Bronchoscopy; D004285:Dogs; D004847:Epithelial Cells / Q000166:cytology / Q000528:radiation effects*; D020007:Implants, Experimental / Q000009:adverse effects; D053685:Laser Therapy / Q000379:methods*; D010865:Pilot Projects; D014135:Tracheal Stenosis / Q000209:etiology / Q000473:pathology / Q000628:therapy*