Exaggerated blood pressure response to exercise is associated with augmented rise of angiotensin II during exercise.
OBJECTIVE
The aim of this study was to investigate the association between an exaggerated blood pressure (BP) response to exercise and augmented angiotensin (Ang) II rise during exercise.


BACKGROUND
Although a central pressor effect of Ang II has been implicated in the pathogenesis of hypertension, the relationship between Ang II and exaggerated BP response to exercise is unclear.


METHODS
Thirty-six subjects with an exaggerated BP response to exercise (18 men, age 50 +/- 16 years, Group II) were compared with 36 age- and gender-matched control subjects (18 men, age 50 +/- 16 years, Group I) with normal BP reactivity. The subjects who had resting BP >or=140/90 mm Hg or were treated with any antihypertensive drugs were excluded. The blood was sampled at rest and immediately after peak exercise for measurement of renin, Ang II, aldosterone, and catecholamine.


RESULTS
At rest, there were no significant differences in BP, renin, aldosterone, and catecholamine levels between the 2 groups. The renin, aldosterone, and catecholamine were increased during exercise, but there were no significant differences between the groups. However, log Ang II at rest (0.78 +/- 0.32 vs. 0.98 +/- 0.38, p = 0.004) and peak exercise (0.84 +/- 0.35 vs. 1.17 +/- 0.51, p < 0.001) and the magnitude of the increment of log Ang II with exercise (0.06 +/- 0.12 vs. 0.19 +/- 0.20, p = 0.003) were significantly higher in the exaggerated BP response group.


CONCLUSIONS
An exaggerated BP response to exercise was associated with augmented rise of Ang II during exercise.
Shim
Chi Young
CY
Cardiology Division, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, South Korea.
Ha
Jong-Won
JW
Park
Sungha
S
Choi
Eui-Young
EY
Choi
Donghoon
D
Rim
Se-Joong
SJ
Chung
Namsik
N
D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood*; D001642:Bicycling; D001794:Blood Pressure; D016022:Case-Control Studies; D002395:Catecholamines / Q000097:blood; D003971:Diastole; D015444:Exercise; D005080:Exercise Test; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000097:blood; D012083:Renin / Q000097:blood; D013318:Stroke Volume
D002395:Catecholamines; D018377:Neurotransmitter Agents; D000804:Angiotensin II; D000450:Aldosterone; D012083:Renin