title: Comparative in vitro activity of l-ofloxacin and FK037 to other agents against 10,040 fresh clinical isolates.
abstract: Fresh clinical isolates collected from November 1, 1992 through November 1, 1993, were tested by agar dilution against 26 different antimicrobial agents including FK037 and l-ofloxacin. Among the 10 040 organisms tested were Staphylococcus aureus (n = 1222), methicillin-resistant Staphylococcus aureus (MRSA, n = 455), Staphylococcus epidermidis (n = 533), Staphylococcus hominis (n = 90), Staphylococcus hemolyticus (n = 89), Streptococcus pneumoniae (n = 144), Escherichia coli (n = 2326), Klebsiella pneumoniae (n = 745), Enterobacter cloacae (n = 258), Proteus mirabilis (n = 445), Pseudomonas aeruginosa (n = 998), and Stenotrophomonas (Xanthomonas) maltophilia (n = 102). Both l-ofloxacin and FK037 inhibited 98% of S. aureus strains at 4 mug/ml. FK037 was at least 4 times more effective than the third generation cephalosporins against MRSA, inhibiting 79% of the strains at 16 mug/ml. While the potency of these agents looks promising, their clinical utility will depend in part upon the maximal dosage that can be safely administered.
authors.affiliation: Clinical Microbiology Section, Pathology Department, Northwestern Memorial Hospital, Northwestern University Medical School, Wesley Pavilion, Room 565, 250 E. Superior Street, Chicago, IL 60611, USA.
authors.forename: I
authors.initials: I
authors.lastname: Cooper
authors.forename: D J
authors.initials: DJ
authors.lastname: Isbell
authors.forename: J A
authors.initials: JA
authors.lastname: Kruszynski
authors.forename: L R
authors.initials: LR
authors.lastname: Peterson