title: Randomized controlled trial comparing gastrectomy plus chemotherapy with chemotherapy alone in advanced gastric cancer with a single non-curable factor: Japan Clinical Oncology Group Study JCOG 0705 and Korea Gastric Cancer Association Study KGCA01.
abstract: A randomized controlled trial has started in both Japan and Korea to evaluate the role of gastrectomy in the management of incurable advanced gastric cancer (AGC). Patients with AGC diagnosed as having a single non-curable factor are randomized to gastrectomy plus chemotherapy or chemotherapy alone. Surgeons at 33 specialized centers in Japan and at 15 high-volume hospitals in Korea will recruit 330 patients. Primary end-point is overall survival, and secondary end-points are progression-free survival and adverse events associated with either gastrectomy or chemotherapy.
authors.affiliation: Department of Surgery, National Osaka Medical Center, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan. fujitani@onh.go.jp
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Fujitani
authors.forename: Han-Kwang
authors.initials: HK
authors.lastname: Yang
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Kurokawa
authors.forename: Do Joong
authors.initials: DJ
authors.lastname: Park
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Tsujinaka
authors.forename: Byung-Joo
authors.initials: BJ
authors.lastname: Park
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Fukuda
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Noh
authors.forename: Narikazu
authors.initials: N
authors.lastname: Boku
authors.forename: Yung-Jue
authors.initials: YJ
authors.lastname: Bang
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Sasako
authors.forename: Jong-Inn
authors.initials: JI
authors.lastname: Lee
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002985:Clinical Protocols; D005743:Gastrectomy; D006801:Humans; D007564:Japan; D007723:Korea; D008875:Middle Aged; D018579:Patient Selection; D012107:Research Design; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*