Comparison of radiotherapy strategies for locally advanced hypopharyngeal cancer after resection and ileocolic flap reconstruction.
CONCLUSIONS
IMRT provided better conformity, less toxicity and better function restoration for advanced hypopharyngeal carcinoma after major surgery with ileocolic flap reconstruction.


OBJECTIVE
To compare the results of adjuvant conventional radiotherapy (2DRT) with intensity modulated radiation therapy (IMRT) for locally advanced hypopharyngeal cancer after resection and ileocolic free flap reconstruction and to design treatment plans for those two modalities plus 3D conformal radiotherapy (3DCRT) for dose distribution comparison.


METHODS
13 locally advanced hypopharyngeal cancer patients were enrolled, 8 treated with 2DRT and 5 with IMRT. Different plans were planned for 3 IMRT-treated patients for comparing dose distribution.


RESULTS
After major surgery, patients treated with IMRT had less toxicity and better functional restoration than those with 2DRT. IMRT and 3DCRT both showed lower dose to the spinal cord than did 2DRT. Only IMRT showed reduced dose to ileocolic flap.
Tai
Hung-Chi
HC
Department of Radiation Oncology, Mackay Memorial Hospital, 92 Chung San North Road Section 2, Taipei 104,Taiwan.
Hsieh
Chen-Hsi
CH
Chao
K S Clifford
KS
Liu
Shih-Hua
SH
Leu
Yi-Shing
YS
Chang
Yih-Fang
YF
Hsiao
Hung-Tao
HT
Chang
Yuan-Ching
YC
Huang
David Yc
DY
Chen
Yu-Jen
YJ
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D020266:Radiotherapy, Conformal; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies; D013116:Spinal Cord / Q000528:radiation effects; D013524:Surgical Flaps; D016896:Treatment Outcome