title: Finding the right research question: quality science depends on quality careers.
abstract: When making the transition from trainee to principal investigator, there are few steps more important than selecting the first independent research project. The project must synthesize the excitement and idealism of contributing to the well-being of humankind and the practical realities of an area of inquiry that is likely to lead to a successful career.
authors.affiliation: Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA. dflockha@iupui.edu
authors.forename: D A
authors.initials: DA
authors.lastname: Flockhart
authors.forename: D R
authors.initials: DR
authors.lastname: Abernethy
mesh_terms: D035843:Biomedical Research / Q000458:organization & administration*; D002322:Career Mobility; D006801:Humans; D010601:Pharmacology, Clinical / Q000639:trends*; D011786:Quality Control; D012108:Research Personnel / Q000458:organization & administration*