Improved biocompatibility and pharmacokinetics of silica nanoparticles by means of a lipid coating: a multimodality investigation.
Silica is a promising carrier material for nanoparticle-facilitated drug delivery, gene therapy, and molecular imaging. Understanding of their pharmacokinetics is important to resolve bioapplicability issues. Here we report an extensive study on bare and lipid-coated silica nanoparticles in mice. Results obtained by use of a wide variety of techniques (fluorescence imaging, inductively coupled plasma mass spectrometry, magnetic resonance imaging, confocal laser scanning microscopy, and transmission electron microscopy) showed that the lipid coating, which enables straightforward functionalization and introduction of multiple properties, increases bioapplicability and improves pharmacokinetics.
van Schooneveld
Matti M
MM
Condensed Matter and Interfaces, University Utrecht, P.O. Box 80000, 3508 TA Utrecht, The Netherlands.
Vucic
Esad
E
Koole
Rolf
R
Zhou
Yu
Y
Stocks
Joanne
J
Cormode
David P
DP
Tang
Cheuk Y
CY
Gordon
Ronald E
RE
Nicolay
Klaas
K
Meijerink
Andries
A
Fayad
Zahi A
ZA
Mulder
Willem J M
WJ
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics*; D008055:Lipids / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D051379:Mice; D008810:Mice, Inbred C57BL; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics*
D001672:Biocompatible Materials; D008055:Lipids; D012822:Silicon Dioxide