title: Acute cytomegalovirus infection superimposed on corticosteroid-naïve ulcerative colitis.
abstract: Most cases of cytomegalovirus (CMV) colitis that develop in patients with inflammatory bowel disease (IBD) are caused by a reactivation of a latent virus; acute CMV infections are rare. Treatment with immunosuppressive agents further increases the infection risk. Here, we present a 32-year-old man with acute CMV-mononucleosis and colitis, superimposed on corticosteroid-naïve ulcerative colitis (UC). The diagnosis was confirmed by a viral-like prodrome, positive CMV antigenemia (C7-HRP), a positive CMV IgM titer, the presence of atypical lymphocytes, mild transaminase elevation, and immunohistological detection of CMV positive cells in his colonic mucosa. Gancyclovir was intravenously administered, and all symptoms were improved.
authors.affiliation: Department of Medicine, Shiga University of Medical Science, Otsu.
authors.forename: Rie
authors.initials: R
authors.lastname: Osaki
authors.forename: Akira
authors.initials: A
authors.lastname: Andoh
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Tsujikawa
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Ogawa
authors.forename: Yuhsuke
authors.initials: Y
authors.lastname: Koizumi
authors.forename: Tamio
authors.initials: T
authors.lastname: Nakahara
authors.forename: Kazunori
authors.initials: K
authors.lastname: Hata
authors.forename: Masaya
authors.initials: M
authors.lastname: Sasaki
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Saito
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Fujiyama
mesh_terms: D000208:Acute Disease; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000150:complications*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications / Q000821:virology*; D008297:Male
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir