A new hTopo I isomerase inhibitor produced by a mangrove endophytic fungus no. 2240.
A new hTopo I isomerase inhibitor, (+)-3,3',7,7',8,8'-hexahydroxy-5,5'-dimethylbianthraquinone (2240A), was isolated from the mangrove endophytic fungus no. 2240 collected from an estuarine mangrove at the South China Sea coast. Its structure was elucidated by spectral analyses including two-dimensional NMR, HR-EI-MS, IR, and UV. The hTopo I isomerase inhibition experiment showed that 2240A (1) possessed strong inhibiting activity. When its inhibition concentration was 4.65 micromol/l, its percent inhibition rate was 59.1%, while the lowest inhibition concentration of the positive control camptothecin was 1.00 x 10(3) micromol/l.
Tan
Ni
N
School of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou, China.
Cai
Xiao-Ling
XL
Wang
San-Yong
SY
Pan
Jia-Hui
JH
Tao
Yi-Wen
YW
She
Zhi-Gang
ZG
Zhou
Shi-Ning
SN
Lin
Yong-Cheng
YC
Vrijmoed
Lilian L P
LL
D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D059004:Topoisomerase I Inhibitors
C532676:3,3',7,7',8,8'-hexahydroxy-5,5'-dimethylbianthraquinone; D000880:Anthraquinones; D059004:Topoisomerase I Inhibitors