HRMS directly from TLC slides. A powerful tool for rapid analysis of organic mixtures.
High-resolution mass spectra (HRMS) of individual spots on thin-layer chromatography (TLC) slides can now be obtained quickly and easily at atmospheric pressure, with zero sample preparation, using commercially available instrumentation. The method is complementary to GC-mass spectrometry but is not limited to compounds of high volatility and high thermal stability. TLC-HRMS can be used to monitor chemical reactions in real time and has the capacity thereby to accelerate significantly the pace of synthetic organic chemistry.
Smith
Natalie J
NJ
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467-3860, USA.
Domin
Marek A
MA
Scott
Lawrence T
LT
D002855:Chromatography, Thin Layer / Q000295:instrumentation / Q000379:methods*; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D008567:Membranes, Artificial; D015394:Molecular Structure; D009930:Organic Chemicals / Q000032:analysis*; D012680:Sensitivity and Specificity
D008567:Membranes, Artificial; D009930:Organic Chemicals