Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives.
Sarcopenia is a loss of muscle protein mass and loss of muscle function. It occurs with increasing age, being a major component in the development of frailty. Current knowledge on its assessment, etiology, pathogenesis, consequences and future perspectives are reported in the present review. On-going and future clinical trials on sarcopenia may radically change our preventive and therapeutic approaches of mobility disability in older people.
Rolland
Y
Y
Inserm U558, F-31073Toulouse, France. rolland.y@chu-toulouse.fr
Czerwinski
S
S
Abellan Van Kan
G
G
Morley
J E
JE
Cesari
M
M
Onder
G
G
Woo
J
J
Baumgartner
R
R
Pillard
F
F
Boirie
Y
Y
Chumlea
W M C
WM
Vellas
B
B
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D016330:Frail Elderly; D006801:Humans; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000502:physiology / Q000503:physiopathology*; D009133:Muscular Atrophy / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000517:prevention & control