title: Sialyl alpha(2-->3) lactose clusters using carbosilane dendrimer core scaffolds as influenza hemagglutinin blockers.
abstract: An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with sialyl alpha(2-->3) lactose (Neu5Acalpha(2-->3)Galbeta(1-->4)Glcbeta1-->) moieties was accomplished. The results of a preliminary study on biological responses against influenza virus hemagglutinin, using the sialyl lactose clusters showed unique biological activities on the basis of the structure-activity relationship according to the carbosilane scaffolds.
authors.affiliation: Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Oka
authors.forename: Tomotsune
authors.initials: T
authors.lastname: Onaga
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Koyama
authors.forename: Chao-Tan
authors.initials: CT
authors.lastname: Guo
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Esumi
authors.forename: Ken
authors.initials: K
authors.lastname: Hatano
authors.forename: Daiyo
authors.initials: D
authors.lastname: Terunuma
authors.forename: Koji
authors.initials: K
authors.lastname: Matsuoka
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006386:Hemagglutination Tests; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000378:metabolism*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects; D007785:Lactose / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010222:Parainfluenza Virus 1, Human / Q000187:drug effects; D012821:Silanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D050091:Dendrimers; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D012821:Silanes; D007785:Lactose