Just the FACTs: histone H2B ubiquitylation and nucleosome dynamics.
In this issue of Molecular Cell, Fleming et al. (2008) show that histone H2B ubiquitylation and FACT function interdependently to facilitate nucleosome reassembly during transcription elongation, thereby demonstrating that histone posttranslational modifications can provide important but transient transcriptional signaling cues.
Hartzog
Grant A
GA
Department of MCD Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA. hartzog@biology.ucsc.edu
Quan
Tiffani K
TK
D002843:Chromatin / Q000378:metabolism; D006657:Histones / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D008745:Methylation; D009707:Nucleosomes / Q000378:metabolism*; D011485:Protein Binding; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000378:metabolism*; D014158:Transcription, Genetic; D054875:Ubiquitination
D002843:Chromatin; D006657:Histones; D009707:Nucleosomes; D008239:Lysine