[Advances in the study of A2B adenosine receptor antagonists].
A2B adenosine receptor is involved in the control of mast cell degranulation, interleukin-8 synthesis and cell growth. A2B adenosine receptor antagonists may serve as novel drugs for asthma, Alzheimer' s disease, cystic fibrosis and type-II diabetes. Therefore, seeking for the highly selective A2B adenosine receptor antagonists has been one of great interest. The molecular basis, structure-activity relationship of selective A2B adenosine receptor antagonists and their interactions with A2B adenosine receptor were reviewed.
Wei
Jing
J
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
Yu
Wen-Quan
WQ
Gao
Qing-Zhi
QZ
D000241:Adenosine / Q000494:pharmacology; D058917:Adenosine A2 Receptor Antagonists; D058918:Adenosine A3 Receptor Antagonists; D019830:Adenosine-5'-(N-ethylcarboxamide) / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy; D006801:Humans; D011651:Pulmonary Artery / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014970:Xanthines / Q000494:pharmacology
D058917:Adenosine A2 Receptor Antagonists; D058918:Adenosine A3 Receptor Antagonists; D018927:Anti-Asthmatic Agents; D014970:Xanthines; D019830:Adenosine-5'-(N-ethylcarboxamide); D000241:Adenosine