Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles.
A series of novel actinonin derivatives containing a benzimidazole heterocycle linked as amide isostere have been designed and synthesized. The structures of all the synthesized compounds were confirmed by analytical and spectroscopic methods. All the compounds were evaluated in vitro against Staphylococcus aureus, Klebsiella pneumoniae, and Sarcina lutea. Among them, compound 1a with unsubstituted benzimidazole ring exhibited potent antibacterial activities.
Zhang
Datong
D
School of Chemistry and Chemical Engineering, Shandong University, 27 Shanda Nanlu, Jinan, Shandong 250100, PR China.
Wang
Zongheng
Z
Xu
Weiren
W
Sun
Fanggang
F
Tang
Lida
L
Wang
Jianwu
J
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001562:Benzimidazoles / Q000737:chemistry*; D015195:Drug Design; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012505:Sarcina / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; D006877:Hydroxamic Acids; C010531:actinonin