title: Influence of adjunct azithromycin on the mortality of experimental Pseudomonas aeruginosa sepsis.
abstract: The aim of this study was to determine the in vivo influence of azithromycin subinhibitory concentrations on mortality in a peritonitis-sepsis model. One hour after an intraperitoneal injection of Pseudomonas aeruginosa, mice were randomized to receive: ceftazidime, 500 mg/kg SC q4hxtwo doses alone; azithromycin, 20 mg/kg SCxone dose alone; ceftazidime plus azithromycinxone dose; ceftazidime plus azithromycinxtwo doses (1 and 24 h); ceftazidime plus prophylactic azithromycin (three doses at -48, -24, 1 h); or no treatment (control). A significant decrease in the rate of mortality was observed in animals treated with all ceftazidime plus azithromycin groups when compared with those receiving ceftazidime alone. These data indicate a potential role for adjunctive azithromycin therapy in P. aeruginosa infection.
authors.affiliation: Department of Pharmacy, Hartford Hospital, 80 Seymour Street, Hartford, CT 06 102, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Nicolau
authors.forename: M A
authors.initials: MA
authors.lastname: Banevicius
authors.forename: M N
authors.initials: MN
authors.lastname: Marangos
authors.forename: M E
authors.initials: ME
authors.lastname: Klepser
authors.forename: R
authors.initials: R
authors.lastname: Quintiliani
authors.forename: C H
authors.initials: CH
authors.lastname: Nightingale