Membrane antigen expression in Epstein-Barr virus-infected Raji cells in the presence of phosphonoacetic acid.
The expression of the Epstein-Barr virus (EBV)-induced membrane antigen (MA) in Raji cells experimentally infected with EBV concentrates was inhibited by phosphonoacetic acid (PAA) as determined by membrane immunofluorescence and inhibition of antibody-dependent lymphocyte cytotoxicity. PAA was only effective if present during the first 24 hr following virus adsorption, indicating that the synthesis of MA was primarily a late viral gene function requiring viral DNA synthesis.
Granlund
D J
DJ
Department of Microbiology, Mayo Clinic, Rochester, Minnesota 55901, USA.
Pearson
G R
GR