Behavioral effects of 1-(m-chlorophenyl)piperazine (m-CPP) in a rat model of tardive dyskinesia.
The present study was designed to monitor the responsiveness of 5-hydroxy tryptamine (5-HT)-2C receptor in rats treated with haloperidol exhibiting tardive dyskinesia (TD). Results show that haloperidol injected at a dose of 1 mg/kg twice a day for two weeks elicited vacuous chewing movements (VCMs). Which increased in a time dependent manner following the drug administration for 3-5 weeks. The behavioral effects of 1-(m-chlorophenyl)piperazine (m-CPP) a 5-HT-2C and 5-HT-1B agonist were monitored 2 days after 5 weeks of saline or haloperidol administration. The results show that hypophagic as well as anxiogenic-like effects of m-CPP are greater in repeated haloperidol than repeated saline injected animals, while hypolocomotive effects of m-CPP are not different in repeated saline and haloperidol injected animals. Results are discussed in the context of role of 5-HT-2C receptors in the regulation of the activity of dopaminergic neuron and its possible impact on elicitation of TD.
Samad
Noreen
N
Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Unit, University of Karachi, Karachi, Pakistan. noreensamad_ku@yahoo.com
Haleem
Muhammad A
MA
Haleem
Darakhshan J
DJ
D000818:Animals; D001007:Anxiety / Q000139:chemically induced; D001522:Behavior, Animal / Q000187:drug effects*; D004195:Disease Models, Animal; D018492:Dopamine Antagonists; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000523:psychology; D004435:Eating / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D006220:Haloperidol; D008409:Mastication / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D010879:Piperazines / Q000009:adverse effects / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D044405:Receptor, Serotonin, 5-HT2C / Q000378:metabolism; D058826:Serotonin 5-HT2 Receptor Agonists; D017366:Serotonin Receptor Agonists / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors
D018492:Dopamine Antagonists; D010879:Piperazines; D044405:Receptor, Serotonin, 5-HT2C; D058826:Serotonin 5-HT2 Receptor Agonists; D017366:Serotonin Receptor Agonists; D006220:Haloperidol; C015068:1-(3-chlorophenyl)piperazine