title: Orally ingested chrysotile asbestos affects rat lungs and pleura.
abstract: The authors designed this study to show the effects of orally ingested asbestos on the lungs and pleura. They designated 3 groups of rats: group A (n = 18) was given 1.5 g/L asbestos in water, group B (n = 18) was given 3 g/L asbestos in water, and group C (n = 15), as a control group, was given only water. Histopathological evaluation of lungs and pleura of the rats after 6 months revealed significant mesothelial proliferation and asbestos bodies. After 9 months, more rats exhibited mesothelial proliferation in group B than in group A (p < .05). The number of rats with asbestos bodies in their lungs was greater in group B than in group A. More rats in group B than in group A had asbestos in their spleen. The authors observed mesothelial proliferation in all group B rats at the end of 12 months. Ingested asbestos traveled from the gastrointestinal system to the lungs, likely via a lymphohematological route, leading to mesothelial proliferation, which may lead to malignancies.
authors.affiliation: Division of Pulmonary Diseases, Ankara Ataturk Training and Research Hospital, Ankara, Turkey. hhasanoglu@gmail.com
authors.forename: H Canan
authors.initials: HC
authors.lastname: Hasanoglu
authors.forename: Erkut
authors.initials: E
authors.lastname: Bayram
authors.forename: Adnan
authors.initials: A
authors.lastname: Hasanoglu
authors.forename: Funda
authors.initials: F
authors.lastname: Demirag
mesh_terms: D000284:Administration, Oral; D000818:Animals; D017632:Asbestos, Serpentine / Q000008:administration & dosage / Q000633:toxicity*; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D008654:Mesothelioma / Q000139:chemically induced; D010994:Pleura / Q000187:drug effects* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D014421:Turkey
chemical_list: D017632:Asbestos, Serpentine