title: The impact of parathyroid gland autotransplantation during bilateral thyroid surgery for Graves' disease on postoperative hypocalcaemia.
abstract: OBJECTIVE
  The aim of this study was to compare the rate of hypocalcaemia after bilateral thyroid resection for Graves' Disease in patients with and without parathyroid gland autotransplantation (PTAT).
  
  
  METHODS
  A total of 153 patients following thyroid surgery for Graves' disease were studied. Patients were divided into three groups. Subgroup I comprised of 129 patients without PTAT, Subgroup II comprised of 19 patients with PTAT of one parathyroid gland and Subgroup III comprised of 6 patients with PTAT of two parathyroid glands. Association between PTAT and postoperative hypocalcaemia (PH) after thyroidectomy was investigated.
  
  
  RESULTS
  There were 27/128 (21.1%) patients with transient and 10/128 (7.8%) patients with permanent hypocalcemia within Subgroup I. Among Subgroup II 4/19 (21.1%) patients developed transient and no patient developed permanent hypocalcaemia, while in Subgroup III 2/6 (33.3 %) patients developed transient hypocalcaemia which became persistent. Thus, the frequency of permanent postthyroidectomy hypocalcaemia (PH) was significantly higher in the Subgroup III with PTAT of two parathyroid glands when compared to the Subgroup I without PTAT (p=0.032) and Subgroup II with PTAT of only one parathyroid glands (p=0.012).
  
  
  CONCLUSIONS
  PTAT of one parathyroid gland is an effective procedure to reduce the incidence of permanent hypoparathyroidism after bilateral surgery for Graves disease. Transient hypoparathyroidism was not influenced by PTAT.
authors.affiliation: Departement of Visceral-,Thoracic- and Vascular Surgery, University of Giessen and Marburg, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Karakas
authors.forename: T
authors.initials: T
authors.lastname: Osei-Agyemang
authors.forename: K
authors.initials: K
authors.lastname: Schlosser
authors.forename: S
authors.initials: S
authors.lastname: Hoffmann
authors.forename: A
authors.initials: A
authors.lastname: Zielke
authors.forename: M
authors.initials: M
authors.lastname: Rothmund
authors.forename: I
authors.initials: I
authors.lastname: Hassan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006111:Graves Disease / Q000601:surgery*; D006801:Humans; D006996:Hypocalcemia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000637:transplantation*; D011183:Postoperative Complications / Q000097:blood*; D013965:Thyroidectomy / Q000009:adverse effects*; D014182:Transplantation, Autologous