title: On the two-ligand catalytic asymmetric deprotonation of N-boc pyrrolidine: probing the effect of the stoichiometric ligand.
abstract: To map out the stoichiometric ligand requirements in the two-ligand catalytic asymmetric deprotonation of N-Boc pyrrolidine, 24 different ligands have been evaluated; the highest enantioselectivity (90:10 er) was obtained by using s-BuLi in the presence of 0.3 equiv of (-)-sparteine and 1.3 equiv of a cyclohexanediamine-derived ligand.
authors.affiliation: Department of Chemistry, University of York, Heslington, York, YO10 5DD, United Kingdom.
authors.forename: Julia L
authors.initials: JL
authors.lastname: Bilke
authors.forename: Peter
authors.initials: P
authors.lastname: O'Brien