Acute necrotising pulmonary vasculitis and pulmonary hypertension in a juvenile dog.
A five-month-old female Jack Russell terrier was presented for investigation of acute lethargy, anorexia, coughing, respiratory distress and weakness. Examination findings included cyanosis, a grade 3 of 6 systolic heart murmur and prolonged capillary refill time. Radiography and echocardiography revealed severe pulmonary hypertension, cor pulmonale and right-sided heart failure. Indirect measurement of the systolic pulmonary artery pressure estimated pressures over 100 mmHg. Despite treatment the patient died. Post-mortem examination did not identify a congenital cardiovascular anomaly. Histopathology confirmed acute necrotising pulmonary arteritis and immunohistochemistry failed to identify any immune complex or complement deposition.
Russell
N J
NJ
School of Veterinary & Biomedical Sciences, Division of Health Sciences, School of Veterinary Clinical Science, Murdoch University, South Street, Murdoch, Western Australia 6150, Australia.
Irwin
P J
PJ
Hopper
B J
BJ
Olivry
T
T
Nicholls
P K
PK
D000208:Acute Disease; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006976:Hypertension, Pulmonary / Q000662:veterinary*; D009336:Necrosis / Q000662:veterinary*; D014657:Vasculitis / Q000662:veterinary*; D014700:Verapamil / Q000627:therapeutic use
D014151:Anti-Anxiety Agents; D005665:Furosemide; D014700:Verapamil