title: [Study on preparation of glycyrrhiza total flavones effective components sustained-release pellets and its properties].
abstract: OBJECTIVE
  To prepare the glycyrrhiza total flavones effective components pellets by extrusion-spheronization, and to optimize the formulation of glycyrrhiza total flavones effective components sustained release pellets coated with mixed Eudragit RS 100.
  
  
  METHODS
  The sustained-release pellets of glycyrrhiza total flavones were prepared by Glatt fluid bed technique. The factors influencing the drug release behaviors and their properties were evaluated.
  
  
  RESULTS
  The optimal drug sustained-release was shown at the loading weight of copolymers of 6% and the plasticizer concentration of 10%. And the curves of cumulative drug release were fit for Peppas and Higuchi equation.
  
  
  CONCLUSIONS
  The pellets show obviously sustained-release effect.
authors.affiliation: Shanghai University of TCM, Shanghai 201203, China. chlly98@163.com
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Xu
authors.forename: Jun-Song
authors.initials: JS
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.forename: Yi-Han
authors.initials: YH
authors.lastname: Wang
mesh_terms: D000180:Acrylic Resins; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000493:pharmacokinetics; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000493:pharmacokinetics; D000431:Ethanol / Q000737:chemistry; D005079:Excipients / Q000737:chemistry; D047309:Flavones / Q000737:chemistry* / Q000493:pharmacokinetics; D006035:Glycyrrhiza / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D005079:Excipients; D047309:Flavones; D011108:Polymers; D013607:Tablets; C050528:Eudragit RS; D000431:Ethanol; D011092:Polyethylene Glycols