[Studies on solubility enhancement of curcumin by Polyvinylpyrrolidione K30].
OBJECTIVE
To study solubility enhancement of curcumin by Polyvinylpyrrolidione K30 (PVP K30).


METHODS
Solid dispersion systems (SDS) of curcumin in PVP K30 were prepared at various weight ratios by co-evaporation of curcumin and PVP K30 ethanol solution. The differential scanning calorimetry (DSC) and powder X-ray diffractometer method were used to describe the status of curcumin in carriers, the UV spectrometry method for determination of curcumin in mediums was established.


RESULTS
The curcumin SDS was successfully prepared, the UV spectrometry method was accurate and reliable, and no interference occurred from carrier. The solubility rate in vitro of curcumin was significantly raised. Compared to curcumin, the solubility of curcumin in SDS increased at least 880 folds.


CONCLUSIONS
PVP K30 improves the solubility of curcumin well.
Xu
Dong-hui
DH
Laboratory of TCM and Marine Drugs, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Wang
Sheng
S
Mei
Xue-ting
XT
Luo
Xiao-ju
XJ
Xu
Shi-bo
SB
D002626:Chemistry, Pharmaceutical; D030024:Curcuma / Q000737:chemistry; D003474:Curcumin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D011208:Powders; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D005079:Excipients; D011208:Powders; D011205:Povidone; D003474:Curcumin