Studies on leukemia development in the SJL/J strain of mice.
Spontaneous reticulum cell neoplasms developed in 70-80% of intact male and female SJL/J mice at a mean age of 380 days. The neoplasms had a basic histological pattern of a multicellular type-B reticulum cell neoplasm, as designated by Dunn. The tumors were transplanted in isogenic mice. Serial passages of cell suspensions of these tumors were carried on through at least 4 tumor-inducing generations, and the growing transplanted tumors maintained the structure of a reticulum cell neoplasm similar to the original tumor. A histological survey of spontaneous lesions in SJL/J mice revealed different characteristics of reticulum cell neoplasms, some similar to Hodgkin's lesions. Five or ten feedings of 7,12-dimethylbenz-[alpha]anthracene (DMBA) in polyethylene glycol 400 (1 mg DMBA per feeding) to SJL/J mice induced lymphosarcomas in 74-83% of the mice at a mean age of 157-188 days. A single feeding of DMBA induced lymphosarcomas in only 27% of the mice at a mean age of 246 days. These DMBA-induced lymphatic leukemias do not appear to depend on the thymus for development--a 60% incidence of lymphosarcomas was obtained in adult thymectomized mice treated with DMBA, and 27% of the thymectomized DMBA-treated mice developed myeloid leukemia at a mean age of 180 days. Urethan was only slightly leukemogenic in SJL/J mice.
Haran-Ghera
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Department of Experimental Biology, The Weizmann Institute of Science, Rehovoth, Israel.
Kotler
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Meshorer
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D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage*; D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced* / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000139:chemically induced; D007951:Leukemia, Myeloid / Q000139:chemically induced; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012513:Sarcoma, Experimental / Q000139:chemically induced; D013934:Thymectomy
D002273:Carcinogens; D015127:9,10-Dimethyl-1,2-benzanthracene