Mathematical models of energy homeostasis.
Diabetes and obesity present a mounting global challenge. Clinicians are increasingly turning to mechanism-based mathematical models for a quantitative definition of physiological defects such as insulin resistance, glucose intolerance and elevated obesity set points, and for predictions of the likely outcomes of therapeutic interventions. However, a very large range of such models is available, making a judicious choice difficult. To better inform this choice, here we present the most important models published to date in a uniform format, discussing similarities and differences in terms of the decisions faced by modellers. We review models for glucostasis, based on the glucose-insulin feedback control loop, and consider extensions to long-term energy balance, dislipidaemia and obesity.
Pattaranit
Ratchada
R
Warwick Systems Biology Centre, University of Warwick, Coventry CV4 7AL, UK.
van den Berg
Hugo Antonius
HA
D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D005246:Feedback; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008954:Models, Biological; D009765:Obesity / Q000378:metabolism
D001786:Blood Glucose; D007328:Insulin