title: Antimicrobial and cytotoxic activities of Laportea crenulata.
abstract: Crude extracts and 2alpha,3beta,21beta,24beta,28-pentahydroxy-olean-12-ene (1) obtained from the root of Laportea crenulata exhibited remarkable antibacterial activities against both Gram (+) and Gram (-) bacteria. The antifungal activities of crude extracts and compound (1) were also determined. The cytotoxic activities of crude extracts and compound (1) were observed by brine shrimp bioassay and LC(50) value of the compound (1) was found to be 27.54 microg/ml.
authors.affiliation: Phytochemistry Research Laboratories, Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh. mukhlesurrah@yahoo.co.uk
authors.forename: M Mukhlesur
authors.initials: MM
authors.lastname: Rahman
authors.forename: Alam
authors.initials: A
authors.lastname: Khan
authors.forename: M Ekramul
authors.initials: ME
authors.lastname: Haque
authors.forename: M Motiur
authors.initials: MM
authors.lastname: Rahman
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D003603:Cytotoxins / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D007928:Lethal Dose 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology*; D018517:Plant Roots; D027003:Urticaceae / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003603:Cytotoxins; D010936:Plant Extracts