title: [Application of somatostatin combined with oral vancomycin in the treatment of intestinal obstruction after liver transplantation].
abstract: OBJECTIVE
  To investigate the effect of somatostatin combined with oral vancomycin in the treatment of intestinal obstruction after liver transplantation.
  
  
  METHODS
  Fifty-eight cases of intestinal obstruction after liver transplantation from Jan. 2005 to Dec. 2006 were divided into two groups: Group A (from Jan. 2005 to Dec. 2005) received traditional treatment, including fasting,gastrointestinal decompression, maintaining electrolyte and acid-base balance, enteral and parenteral nutrition support and antibiotics; Group B (from Jan. 2006 to Dec. 2006) received somatostatin combined oral vancomycin in addition to the above mentioned traditional treatment.
  
  
  RESULTS
  Fifty-eight cases out of 441 patients (13%) suffered from intestinal obstruction after liver transplantation. Group B had a better outcome as compared with Group A, including a quick recovery of flatus and stool, [(7.1+/-2.0) d and (8.4+/-2.4) d vs (9.1+/-3.0) d and (10.8+/-3.4) d] (P<0.05), less amount of gastric drainage [(298+/-58) ml/d vs (485+/-106) ml/d](P<0.05). The rate of intestinal flora imbalance in Group B was 55%, which was significantly less than the 77% in Group A(P<0.05).
  
  
  CONCLUSIONS
  The application of somatostatin combined with oral vancomycin can improve the symptoms of intestinal obstruction after liver transplantation and decrease the rate of intestinal flora imbalance.
authors.affiliation: Liver Transplantation Center, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Chang-Jie
authors.initials: CJ
authors.lastname: Cai
authors.forename: Min-Ru
authors.initials: MR
authors.lastname: Li
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Yi
authors.forename: Gen-Shu
authors.initials: GS
authors.lastname: Wang
authors.forename: Min-Qiang
authors.initials: MQ
authors.lastname: Lu
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007415:Intestinal Obstruction / Q000188:drug therapy* / Q000209:etiology; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*; D013004:Somatostatin / Q000627:therapeutic use*; D014640:Vancomycin / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D013004:Somatostatin; D014640:Vancomycin