The complexities of diabetic cardiomyopathy: lessons from patients and animal models.
Cardiovascular diseases are foreseeable complications of diabetes mellitus; heart failure is a prominent complication among these. Diabetic cardiomyopathy is a distinct entity independent of coronary artery disease and hypertension. Most of our knowledge on diabetic cardiomyopathy's pathogenesis comes from studies performed on various animal models. The recent advances in the domain confirm that the disease is above all a maladaptation of the heart mostly driven by the metabolic derangements that accompany diabetes mellitus.
Harmancey
Romain
R
Department of Internal Medicine, Division of Cardiology, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 1.246, Houston, TX 77030, USA.
Taegtmeyer
Heinrich
H
D000818:Animals; D009202:Cardiomyopathies / Q000473:pathology*; D048909:Diabetes Complications / Q000473:pathology*; D004195:Disease Models, Animal; D006801:Humans