title: Monoolein-water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization.
abstract: To maximize the efficacy of chronic osteomyelitis antibiotherapy while reducing antibiotic systemic toxicity, as well as time and costs of hospitalizations, it has been thought that monoolein-water gels incorporating gentamicin sulfate could be used as local, bioresorbable,and sustained-release implants. For this purpose, four formulations were examined with regard to their physicochemical and in vitro drug release characteristics. Hot stage microscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA),and X-ray diffraction showed cubic liquid crystalline and eutectic structures. The more suitable formulation consisting of 80-15-5%wt/wt monoolein-water-gentamicin sulfate progressively released the antibiotic for a period of 3 weeks without burst effect. Moreover, the content and the release profile of gentamicin sulfate were not significantly changed after storage at 2-6 degrees C for a period of 10 months.
authors.affiliation: UFR-Sciences de la Santé, Université de Ouagadougou, Ouagadougou, Burkina Faso.
authors.forename: Moustapha
authors.initials: M
authors.lastname: Ouédraogo
authors.forename: Rasmané
authors.initials: R
authors.lastname: Semdé
authors.forename: Issa Toudoridomou
authors.initials: IT
authors.lastname: Somé
authors.forename: Rasmata
authors.initials: R
authors.lastname: Traoré-Ouédraogo
authors.forename: Innocent Pierre
authors.initials: IP
authors.lastname: Guissou
authors.forename: Viviane
authors.initials: V
authors.lastname: Henschel
authors.forename: Jacques
authors.initials: J
authors.lastname: Dubois
authors.forename: Karim
authors.initials: K
authors.lastname: Amighi
authors.forename: Brigitte
authors.initials: B
authors.lastname: Evrard
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D002908:Chronic Disease; D003460:Crystallization; D003692:Delayed-Action Preparations; D004343:Drug Implants; D004355:Drug Stability; D004356:Drug Storage; D005839:Gentamicins / Q000008:administration & dosage* / Q000737:chemistry; D008853:Microscopy / Q000379:methods; D010019:Osteomyelitis / Q000188:drug therapy*; D012995:Solubility; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004343:Drug Implants; D005839:Gentamicins