Vitamin K in hand osteoarthritis: results from a randomised clinical trial.
OBJECTIVE
Vitamin K has bone and cartilage effects, and previously shown to be associated with radiographic osteoarthritis. We evaluated vitamin K's effect on hand osteoarthritis in a randomised controlled trial.


METHODS
This was an ancillary study to a randomised controlled trial assessing the effects of phylloquinone supplementation (vitamin K arm) versus placebo on bone loss and vascular calcification among older adults regardless of their vitamin K status. At the final 3-year study visit, we assessed the effects of vitamin K versus placebo on hand x-ray features of osteoarthritis using logistic regression and intention to treat, and also restricted analysis to the subgroup that had insufficient vitamin K concentrations at baseline.


RESULTS
This ancillary study had 378 participants (193 in vitamin K arm, 185 in placebo arm). There were no effects of randomisation to vitamin K for radiographic osteoarthritis outcomes. Those with insufficient vitamin K at baseline who attained sufficient concentrations at follow-up had trends towards 47% less joint space narrowing (p = 0.02).


CONCLUSIONS
There was no overall effect of vitamin K on radiographic hand osteoarthritis.


METHODS
that were insufficient in vitamin K at baseline who attained sufficient concentrations at follow-up may have had a benefit in joint space narrowing. A clinical trial in those who are vitamin K insufficient may be warranted.


BACKGROUND
NCT00183001.
Neogi
T
T
Boston University School of Medicine, Boston, MA 02118, USA. tneogi@bu.edu
Felson
D T
DT
Sarno
R
R
Booth
S L
SL
D000368:Aged; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D050823:Hand Joints / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D011859:Radiography; D010837:Vitamin K 1 / Q000097:blood / Q000627:therapeutic use*; D014813:Vitamin K Deficiency / Q000097:blood / Q000150:complications
D010837:Vitamin K 1