title: A contrast-enhanced ultrasound study of benign and malignant breast tissue.
abstract: OBJECTIVE
  To determine the diagnostic value of haemodynamic contrast-enhanced ultrasound assessment in benign and malignant breast tissue, using histological examination as the reference standard.
  
  
  METHODS
  An HDI 5000 Phillips ultrasound scanner with microvascular imaging software and 2.5 ml SonoVue (Bracco spa, Milan) contrast was used to scan 50 consecutive patients (32 malignant and 18 benign, 49 with histologically confirmed breast lesions). Time-intensity curves of the regions of interest (ROI) placed over the lesional and normal breast tissues were acquired using QLAB software. The area under the curve (AUC), time to peak (TTP), in-flow gradient (IFG) and peak enhancement (PE) were determined in a standardised manner for each focal breast lesion and the control/normal breast. IFG and AUC in the periphery, and PE and AUC in the centre of the lesions, differed significantly between malignant and benign tumours. In a logistical regression model, AUC in the periphery and the ratio of PE at the tumour centre to that of normal breast were independently predictive of malignancy (p < 0.001), achieving a diagnostic sensitivity of 97% and a specificity of 80% in the 41 tumours in which central vessels could be distinguished.
  
  
  CONCLUSIONS
  Haemodynamic contrast-enhanced ultrasound assessment can be used to distinguish between benign and malignant breast lesions.
authors.affiliation: Department of Surgery, Glasgow Royal Infirmary, UK. s6b7@yahoo.com
authors.forename: Serita
authors.initials: S
authors.lastname: Barnard
authors.forename: Edward
authors.initials: E
authors.lastname: Leen
authors.forename: Timothy
authors.initials: T
authors.lastname: Cooke
authors.forename: Wilson
authors.initials: W
authors.lastname: Angerson
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D005260:Female; D005348:Fibrocystic Breast Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010743:Phospholipids; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D013459:Sulfur Hexafluoride; D016217:Ultrasonography, Mammary
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride