Influence of Lys656Asn polymorphism of leptin receptor gene on insulin resistance in patients with diabetes mellitus type 2.
This is a descriptive study in diabetic patients. Mutant type patient (39%) (Lys656/Asn656 or Asn656/Asn656) group had higher fat mass, HOMA, CRP and leptin than wild type. Adiponectin levels were lower in mutant type group than wild type (61%) (Lys656/Lys656).
de Luis
D A
DA
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. Dadluis@yahoo.es
Gonzalez Sagrado
M
M
Aller
R
R
Izaola
O
O
Conde
R
R
D019943:Amino Acid Substitution; D001216:Asparagine; D015992:Body Mass Index; D016207:Cytokines / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000235:genetics*; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D008239:Lysine; D009765:Obesity / Q000150:complications / Q000235:genetics; D011110:Polymorphism, Genetic; D054411:Receptors, Leptin / Q000235:genetics*
D016207:Cytokines; D054411:Receptors, Leptin; D001216:Asparagine; D008239:Lysine