title: The relationships between titers of anti-Ro or anti-La as measured by ELISA and salivary production rate with age correction.
abstract: The objective of this work was to clarify the clinical significance of titers of anti-Ro and anti-La, the relationships between titers of either anti-Ro or anti-La, and salivary production rate (SPR). These autoantibodies were titrated using enzyme-linked immunosorbent assay. The Saxon test was performed to measure SPR. Fifty-one females who had anti-Ro but not anticentromere antibodies or anti-U1RNP were enrolled. SPR decreased significantly with age. In order to exclude the effect of aging on SPR, we calculated the "SPR with age correction." According to the results of a multiple regression analysis, only the anti-La titer was significantly associated with SPR with age correction. The distribution pattern of the anti-La titers consisted of two subgroups (with a titer index cutoff of 100.0): a negative anti-La titer (anti-La<25.0) and low anti-La titer (25.0<or=anti-La<100.0) group, and a high anti-La titer group (anti-La>or=100.0). The concentration of serum IgG and the frequency of Sjögren's syndrome in the high anti-La titer group were significantly higher than those in the negative anti-La and low anti-La titer group. Several new aspects of the clinical significance of titrating anti-Ro and anti-La in comparison with SPR have been revealed.
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan. dr20021@ndmc.ac.jp
authors.forename: Kunio
authors.initials: K
authors.lastname: Takada
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Suzuki
authors.forename: Mitsuyo
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Okada
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Horikoshi
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Higuchi
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Nakayama
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Ohsuzu
mesh_terms: D000367:Age Factors; D001324:Autoantigens / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016014:Linear Models; D008875:Middle Aged; D012216:Rheumatic Diseases / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D012261:Ribonucleoproteins / Q000276:immunology*; D012463:Saliva / Q000276:immunology* / Q000378:metabolism; D012469:Salivary Glands / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D000097585:SS-B Antigen; D000099207:SS-A Antigen
chemical_list: D001324:Autoantigens; D007074:Immunoglobulin G; D012261:Ribonucleoproteins; D000097585:SS-B Antigen; D000099207:SS-A Antigen