title: How has the biologic reaction to wear particles changed with newer bearing surfaces?
abstract: Orthopaedic surgeons have new tools that address the problem of aseptic loosening and osteolysis, and these tools are now in widespread clinical use. Hard-on-hard bearing couples as well as metal-on-highly cross-linked polyethylene bearing couples have lower volumetric wear rates and represent promising solutions to reduce the prevalence of osteolysis and aseptic loosening in total joint arthroplasty. Volumetric wear rates alone, however, do not completely predict the osteolytic potential that is also a function of particle composition, size, morphology, and a number of other particle characteristics. Host factors, including differing innate reactivities to wear products and adaptive immune responses, remain important but incompletely defined. Although the toxicologic significance of local and systemic elevations in metal ions has not been definitively established, monitoring patients with metal-on-metal bearings with serum metal ion levels can be useful to determine the state of the bearing. Furthermore, optimization of these bearing systems to further diminish wear and corrosion would be highly desirable.
authors.affiliation: Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Jacobs
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Campbell
authors.forename: Yrjö
authors.initials: Y
authors.lastname: T Konttinen
mesh_terms: D000222:Adaptation, Physiological / Q000276:immunology; D019643:Arthroplasty, Replacement / Q000009:adverse effects / Q000295:instrumentation*; D001672:Biocompatible Materials / Q000009:adverse effects*; D005549:Foreign-Body Reaction / Q000276:immunology* / Q000517:prevention & control*; D006801:Humans; D007595:Joint Prosthesis; D010014:Osteolysis / Q000209:etiology / Q000517:prevention & control*; D010316:Particle Size; D011095:Polyethylenes; D011474:Prosthesis Design; D011475:Prosthesis Failure; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D011095:Polyethylenes