Water-mediated catalyst preactivation: an efficient protocol for C-N cross-coupling reactions.
A protocol for forming a highly active Pd(0) catalyst from Pd(OAc) 2, water, and biaryldialkylphosphine ligands has been developed. This protocol generates a catalyst system, which exhibits excellent reactivity and efficiency in the coupling of a variety of amides and anilines with aryl chlorides.
Fors
Brett P
BP
Department of Chemistry, Massachusetts Institute of Technology, Room 18-490, Cambridge, Massachusetts 02139, USA.
Krattiger
Philipp
P
Strieter
Eric
E
Buchwald
Stephen L
SL
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
D000577:Amides; D000814:Aniline Compounds; D006843:Hydrocarbons, Chlorinated; D008024:Ligands; D010720:Phosphines; D014867:Water; D010165:Palladium