Comparison of a pulsatile blood pump and a peristaltic roller pump during hemoperfusion treatment in a canine model of paraquat poisoning.
This study examined the treatment efficacy and the damage to the blood during hemoperfusion for treating paraquat poisoning using two blood pump mechanisms. Paraquat-poisoned animal models were prepared. A conventional hemodialysis machine, AK90, with a peristaltic roller pump and a cardiopulmonary support system, T-PLS, with a pulsatile blood pump were used during the animal experiments. A total of 12 dogs were treated with hemoperfusion using a charcoal column. Six dogs were treated with hemoperfusion and T-PLS, and the other six were treated with AK90. A paraquat dose of 30 mg/kg was administrated by an intravenous injection. Both pumps maintained blood flow rates of 125 mL/min measured by an ultrasonic flowmeter. For anticoagulation, heparin was administrated by an initial bolus (250 IU/kg) and a continuous injection (100 IU/kg/h). During the experiments, T-PLS and AK90 showed a similar toxin removal efficacy. Both devices decreased the plasma paraquat concentration to 10% of the initial dose within 4-h hemoperfusion. The two pumps showed similar hemolysis properties with acceptable levels. Although T-PLS was developed as a cardiopulmonary bypass system, it can also be used as a hemoperfusion treatment device.
Lee
Jung Chan
JC
Interdisciplinary Program in Medical and Biological Engineering Major, Graduate School, Seoul National University, Seoul, Korea.
Park
Chan Young
CY
Choi
Seong Wook
SW
Kim
Jeong Chul
JC
Lim
Ki Moo
KM
Kim
Kyuseok
K
Jung
Sung Koo
SK
Kwak
Young Ho
YH
Shin
Sang Do
SD
Jo
Ik Joon
IJ
Suh
Gil Joon
GJ
Min
Byoung Goo
BG
D000818:Animals; D002606:Charcoal / Q000627:therapeutic use; D004285:Dogs; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006461:Hemolysis; D006464:Hemoperfusion / Q000295:instrumentation*; D010269:Paraquat / Q000097:blood* / Q000506:poisoning*; D011673:Pulsatile Flow
D002606:Charcoal; D010269:Paraquat