[Metabolic syndrome, a mitochondrial disease?].
The metabolic syndrome is a cluster of metabolic risk factors including: atherogenic dyslipidemia, elevated blood pressure, high plasma glucose and a prothrombotic and proinflammatory state, frequently associated to overweight. Impaired cell metabolism has been suggested as a relevant pathophysiological process. Indeed, the accumulation of intracellular fatty acylCoA and diacylglycerol, which then activate critical signal transduction pathways that ultimatly lead to suppression of insulin signalisation. Therefore a defect in mitochondrial function may be responsible for insulin resistance. Moreover, mitochondrial dysfunction has been found to take place in organs such as skeletal muscle, liver, pancreas and smoth vascular cells suggesting that mitochondrial defect could play a critical role in the occurence of cardiovascular diseases.
Gastaldi
G
G
Service d'endocrinologie, diabétologie et métabolisme, Département de médecine interne, CHUV, Lausanne. Giacomo.Gastaldi@chuv.ch
Giacobino
J P
JP
Ruiz
J
J
D006801:Humans; D024821:Metabolic Syndrome / Q000235:genetics* / Q000503:physiopathology; D008928:Mitochondria / Q000235:genetics* / Q000502:physiology; D010085:Oxidative Phosphorylation