title: Dynamics of haemopoiesis across mammals.
abstract: Haemopoiesis is a fundamental physiologic process found in many animals. Among mammals, the diversity in size and function required suitable adaptations of this process. In this work, we use allometric principles to determine whether this required a change in the basic architecture of haemopoiesis. We show that it is possible to express both the number and rate with which haemopoietic stem cells replicate as well as total marrow output across all mammals as a function of adult mass. This unified view, which is compatible with the existing data, suggests that there was no need for major adaptations in the architecture of haemopoiesis across mammals.
authors.affiliation: Division of Hematology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. dingli.david@mayo.edu
authors.forename: David
authors.initials: D
authors.lastname: Dingli
authors.forename: Arne
authors.initials: A
authors.lastname: Traulsen
authors.forename: Jorge M
authors.initials: JM
authors.lastname: Pacheco
mesh_terms: D000818:Animals; D049628:Body Size / Q000502:physiology; D048708:Cell Growth Processes / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology; D008322:Mammals / Q000502:physiology*