title: The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's disease.
abstract: BACKGROUND
  Subjective cognitive impairment (SCI) has been a common, but poorly understood condition, frequently occurring in older persons.
  
  
  METHODS
  The past and the emerging literature on SCI and synonymously named conditions is reviewed.
  
  
  RESULTS
  Findings include: (1) There is support from at least one longitudinal study for a long-standing concept of SCI as a pre-mild cognitive impairment (MCI) condition lasting approximately 15years. (2) There are complex relationships between SCI and depression and anxiety. (3) Differences in SCI subjects from age-matched non-SCI persons are being published in terms of cognitive tests, hippocampal gray matter density, hippocampal volumes, cerebral metabolism, and urinary cortisol levels. Psychometric and dementia test score differences between SCI and MCI subjects have long been evident. (4) Predictive electrophysiologic features of subsequent decline in SCI subjects are being published.
  
  
  CONCLUSIONS
  Studies of therapeutic agents in SCI treatment and resultant Alzheimer's disease prevention appear to be feasible. These trials are also necessary from a public health perspective.
authors.affiliation: Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, USA. barry.reisberg@med.nyu.edu
authors.forename: Barry
authors.initials: B
authors.lastname: Reisberg
authors.forename: Leslie
authors.initials: L
authors.lastname: Prichep
authors.forename: Lisa
authors.initials: L
authors.lastname: Mosconi
authors.forename: E Roy
authors.initials: ER
authors.lastname: John
authors.forename: Lidia
authors.initials: L
authors.lastname: Glodzik-Sobanska
authors.forename: Istvan
authors.initials: I
authors.lastname: Boksay
authors.forename: Isabel
authors.initials: I
authors.lastname: Monteiro
authors.forename: Carol
authors.initials: C
authors.lastname: Torossian
authors.forename: Alok
authors.initials: A
authors.lastname: Vedvyas
authors.forename: Nauman
authors.initials: N
authors.lastname: Ashraf
authors.forename: Imran A
authors.initials: IA
authors.lastname: Jamil
authors.forename: Mony J
authors.initials: MJ
authors.lastname: de Leon
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D009483:Neuropsychological Tests