title: [Effects of high-carbohydrate/low-fat diet on serum lipid ratios in healthy young subjects].
abstract: OBJECTIVE
  To investigate the effects of the short-term high-carbohydrate/low-fat (HC/LF) diet on the serum lipid ratios of healthy young subjects, which meant triglyceride to high-density lipoprotein cholesterol (TG/HDL-C), the logarithm of TG/HDL-C [log (TG/HDL-C)], low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C), and total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C).
  
  
  METHODS
  56 healthy participants with the average age of (22.89 +/- 1.80) years took the normal diet for 7 days followed by HC/LF diet for 6 days. Venous blood samples in fasting were collected between 7 : 00 and 10 : 00 AM on the 1st, the 8th and 14th day, respectively. Serum concentrations of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were measured by regular methods. The ratios of TG/HDL-C, log (TG/HDL-C), LDL-C/HDL-C, and TC/ HDL-C were calculated.
  
  
  RESULTS
  After HC/LF diet, both TG/HDL-C and log (TG/HDL-C) increased significantly for females (P < 0.05). For the males, these two ratios were decreased although not significant in statistics. When BMI or WHR was taken into account, the two ratios increased significantly after HC/LF diet, but only for the normal females (P < 0.05), not for the females with overall or abdominal adiposity. No significant changes of TG/HDL-C and log(TG/HDL-C) after HC/LF diet were observed between the males with different BMI or WHR. TC/HDL-C and LDL-C/HDL-C decreased significantly (P < 0.05) after HC/LF diet, but these changes were not found to associate with gender, BMI or WHR.
  
  
  CONCLUSIONS
  The changes of TG/HDL-C and log (TG/HDL-C) induced by the short-term HC/LF diet are different in healthy young subjects with different gender, BMI or WHR, but there is no significant change happening to TC/HDL-C and LDL-C/HDL-C.
authors.affiliation: Department of Biochemistry and Molecular Biology Laboratory, West China School of Preclinical and Forensic, Medicine, Sichuan University, Chengdu 610041, China.
authors.forename: Chan-Fen
authors.initials: CF
authors.lastname: Gan
authors.forename: Ren-Rong
authors.initials: RR
authors.lastname: Gong
authors.forename: Jia
authors.initials: J
authors.lastname: Lin
authors.forename: Zheng-Ke
authors.initials: ZK
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Tang
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.forename: Rong-Hui
authors.initials: RH
authors.lastname: Li
authors.forename: Ding-Zhi
authors.initials: DZ
authors.lastname: Fang
mesh_terms: D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D018752:Diet, Fat-Restricted; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D014280:Triglycerides