title: Study on bioactive compounds from Streptomyces sp. ANU 6277.
abstract: An attempt was made to study the bioactive compounds from a terrestrial Streptomyces sp. ANU 6277 isolated from laterite soil. Four active fractions were recovered from the solvent extracts obtained from the culture broth of five day-old strain. Three bioactive compounds were purified and identified as 3-phenylpropionic acid, anthracene-9,10-quinone and 8-hydroxyquinoline. The components of the partially purified fourth active fraction were analyzed by gas chromatography-mass spectrometry and identified as benzyl alcohol, phenylethyl alcohol and 2H-1, 4-benzoxazin-3 (4H)-one. Four active fractions were screened for antimicrobial activity against Gram-positive and Gram-negative bacteria, and fungi including phytopathogenic, toxigenic and dermatophytic genera. Among these metabolites, 8-hydroxyquinoline exhibited strong antibacterial and antifungal activity as compared to 3-phenylpropionic acid and anthracene-9,10-quinone.
authors.affiliation: Department of Microbiology, Acharya Nagarjuna University, Guntur, India.
authors.forename: Kolla J P
authors.initials: KJ
authors.lastname: Narayana
authors.forename: Peddikotla
authors.initials: P
authors.lastname: Prabhakar
authors.forename: Muvva
authors.initials: M
authors.lastname: Vijayalakshmi
authors.forename: Yenamandra
authors.initials: Y
authors.lastname: Venkateswarlu
authors.forename: Palakodety S J
authors.initials: PS
authors.lastname: Krishna
mesh_terms: D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification; D005285:Fermentation; D008401:Gas Chromatography-Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015125:Oxyquinoline / Q000737:chemistry* / Q000302:isolation & purification; D010666:Phenylpropionates / Q000737:chemistry* / Q000302:isolation & purification; D012988:Soil Microbiology; D013302:Streptomyces / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010666:Phenylpropionates; C042834:9,10-anthraquinone; C035253:3-phenylpropionic acid; D015125:Oxyquinoline