[Assessment of bone mineral density in children with celiac disease].
To the reasons of disturbances of bone mineralization in celiac disease belong: absorption impairment due to the changes in mucosa including calcium and vitamin D adsorption, the activation of osteoclasts by proinflammatory cytokines and the decrease in concentration of growth hormone and IGF-1 in the serum. THE AIM OF THE STUDY was to analyze mineral bone density in children with celiac disease.


METHODS
Analysis included 37 children aged 5 to 17 years, treated in our clinic since November 2004 to June 2007 with diagnosed celiac disease. In all children examination of total body bone mineral density (TBMD) was performed using DPX(+) densitometer (Lunar).


RESULTS
The disturbances of mineral bone density were observed in 15 out of 37 children with diagnosed celiac disease which amounted to 40.5%. In patients with celiac disease diagnosed de novo such disturbances were present in 75%.


CONCLUSIONS
The reduction of mineral bone density was present in 40.54% of children with diagnosed celiac disease and in 75% of patients with celiac disease diagnosed de novo. The decrease of BMD correlated with nutritional status and was present only in 30% of properly nourished children and in much higher percent in severely malnourished children. Reduced bone mineral density was observed in 50% of children with mucosa villous atrophy and merely in 8% with proper small intestine mucosa. There is a need of diagnostic scheme for early diagnosis (screening) and treatment of mineral bone density disturbances in children with celiac disease.
Krzesiek
Elzbieta
E
Akademia Medyczna we Wrocławiu, II Katedra i Klinika Pediatrii, Gastroenterologii i Zywienia. ellak@op.pl
Iwańczak
Barbara
B
D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000209:etiology; D002446:Celiac Disease / Q000150:complications*; D002648:Child; D015362:Child Nutrition Disorders / Q000209:etiology; D002675:Child, Preschool; D003720:Densitometry; D005260:Female; D006801:Humans; D008297:Male; D009752:Nutritional Status