Convenient synthesis of 3-alkoxy-3-aryloxindoles by intramolecular arylation of mandelic amides.
Medicinally important 3-alkoxy-3-aryloxindoles are conveniently prepared by the rapid microwave-promoted palladium-catalyzed intramolecular enolate arylation of mandelate-derived anilides.
Hillgren
J Mikael
JM
School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom.
Marsden
Stephen P
SP
D000577:Amides / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis*; D008333:Mandelic Acids / Q000737:chemistry*
D000577:Amides; D001555:Benzene Derivatives; D007211:Indoles; D008333:Mandelic Acids; C037938:mandelic acid