Kayser-Fleischer ring.
Kayser-Fleischer (K-F) ring seen in Wilson's disease (WD) is due to copper deposition in the Descemet's membrane in the sclero-corneal junction. Although believed to be pathognomic of WD, it may be seen in many other hepatic conditions and intraocular copper-containing foreign bodies. The K-F ring detected in pre-symptomatic cases of WD may lead to speedy diagnosis and early management. Co-relation of K-F ring in WD to the disease severity, disappearance with successful treatment, reappearance with non-compliant treatment may aid in optimum management of WD. The importance of K-F ring detection in first-degree relatives of the index case cannot be over-emphasized.
Suvarna
J C
JC
Department of Pediatrics, Seth GS Medical College and KEM Hospital, Mumbai, India. crsuvarna@mtnl.net.in
D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism; D027682:Cation Transport Proteins / Q000235:genetics / Q000378:metabolism; D015913:Chelation Therapy; D003300:Copper / Q000378:metabolism; D000073840:Copper-Transporting ATPases; D003316:Corneal Diseases / Q000209:etiology* / Q000378:metabolism; D003937:Diagnosis, Differential; D006527:Hepatolenticular Degeneration / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D017495:Hyperpigmentation / Q000209:etiology* / Q000473:pathology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D009154:Mutation
D027682:Cation Transport Proteins; D003300:Copper; D000251:Adenosine Triphosphatases; D000073840:Copper-Transporting ATPases