Use of complex DNA and antibody microarrays as tools in functional analyses.
While the deciphering of basic sequence information on a genomic scale is yielding complete genomic sequences in ever-shorter intervals, experimental procedures for elucidating the cellular effects and consequences of the DNA-encoded information become critical for further analyses. In recent years, DNA microarray technology has emerged as a prime candidate for the performance of many such functional assays. Technically, array technology has come a long way since its conception some 15 years ago, initially designed as a means for large-scale mapping and sequencing.The basic arrangement, however, could be adapted readily to serve eventually as an analytical tool in a large variety of applications. On their own or in combination with other methods, microarrays open up many new avenues of functional analysis.
Bauer
Andrea
A
Division of Functional Genome Analysis, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 580, Heidelberg D-69120, Germany.
Beckmann
Boris
B
Busold
Christian
C
Brandt
Ole
O
Kusnezow
Wlad
W
Pullat
Janne
J
Aign
Verena
V
Fellenberg
Kurt
K
Fleischer
Robert
R
Jacob
Anette
A
Frohme
Marcus
M
Hoheisel
Jörg D
JD