title: Ubiquitin C-terminal hydrolase L1 deficiency decreases bone mineralization.
abstract: Ubiquitin C-terminal hydrolase L1 is a component of the ubiquitin proteasome system, which evidences unique biological activities. In this study, we report the pattern of UCH-L1 expression, and show that it regulates bone mineralization in osteogenesis. UCH-L1 was expressed in osteoblasts, osteoclasts, and hematopoietic precursor cells of bone marrow in the metaphysis and diaphysis of the femora. To further assess the involvement of UCH-L1 in the regulation of bone mineralization, we evaluated the bone mineral density (BMD) rate of gad mice, using the Latheta computed tomography system. Male gad mice evidenced a significantly decreased BMD rate in the metaphysis and diaphysis of the femora. These findings of decreased BMD rate in the bones of gad mice may suggest that UCH-L1 function regulates bone mineralization during osteogenesis.
authors.affiliation: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea.
authors.forename: Sehwan
authors.initials: S
authors.lastname: Shim
authors.forename: Young-Bae
authors.initials: YB
authors.lastname: Kwon
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Jungkee
authors.initials: J
authors.lastname: Kwon
mesh_terms: D000818:Animals; D015519:Bone Density; D001853:Bone Marrow / Q000378:metabolism; D002113:Calcification, Physiologic / Q000502:physiology*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D010012:Osteogenesis / Q000502:physiology*; D012737:Sex Factors; D014057:Tomography, X-Ray Computed; D043222:Ubiquitin Thiolesterase / Q000172:deficiency* / Q000378:metabolism
chemical_list: D043222:Ubiquitin Thiolesterase