Gray matter deficits in young adults with narcolepsy.
OBJECTIVE
The aim of this study was to investigate gray matter volume changes in narcolepsy.


METHODS
An optimized voxel-based morphometry was conducted for 17 young adults with a sole diagnosis of human leukocyte antigen DQB(1) 0602 positive narcolepsy with cataplexy (26.6 +/- 5.2 years old) and 17 comparison subjects (24.6 +/- 4.9 years old) using 3 Tesla scanner. Gray matter volumes in the bilateral hypothalamic voxel of interests (VOI) were also calculated.


RESULTS
Compared with the comparison subjects, narcoleptic patients had gray matter volume decrease in the right hypothalamus and other regions including subcortical, prefrontal, limbic and occipital areas. Narcoleptic patients also had lower gray matter volume on predefined VOI at the bilateral hypothalamus, which correlated with the Ullanlinna Narcolepsy Scale score.


CONCLUSIONS
Current findings suggest that narcoleptic patients have structural abnormalities in hypothalamus, which might be related to the clinical manifestation of narcolepsy with cataplexy.
Kim
S J
SJ
Department of Psychiatry, Gachon University of Medicine and Science, Incheon, South Korea.
Lyoo
I K
IK
Lee
Y S
YS
Lee
J-Y
JY
Yoon
S J
SJ
Kim
J E
JE
Kim
J H
JH
Hong
S J
SJ
Jeong
D-U
DU
D000328:Adult; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007031:Hypothalamus / Q000002:abnormalities; D007723:Korea; D008297:Male; D009290:Narcolepsy / Q000473:pathology* / Q000503:physiopathology; D010487:Periaqueductal Gray / Q000033:anatomy & histology / Q000473:pathology*; D012016:Reference Values; D012890:Sleep / Q000502:physiology; D020181:Sleep Apnea, Obstructive / Q000473:pathology* / Q000503:physiopathology; D012895:Sleep, REM / Q000502:physiology; D011795:Surveys and Questionnaires; D055815:Young Adult