title: [Celiac disease: special features in Africa. Description of 8 cases in Djibouti (horn of Africa)].
abstract: Celiac disease is poorly documented in intertropical Africa. The purpose of this retrospective report was to describe 8 cases observed at the Groupement Medico-Chirurgical of Bouffard Hospital in Djibouti (Horn of Africa) between January 2003 and January 2006. There were 5 females and 3 males ranging in age from 9 months to 17 years old (mean age: 48 months). Six patients were of Somali ethnic origin and two of Yemenite ethnic origin. Six were classified as middle class and 2 as lower class. All forms were symptomatic associating constant loss of weight with digestive manifestations (diarrhoea and vomiting). Diagnosis of celiac disease was based on the presence of anti-gliadin antibodies IgA and IgG associated with anti-endomysium or anti-transglutaminase antibodies that were measured in six and two cases respectively. Gastroduodenal endoscopy performed in three cases including two with duodenal biopsy demonstrated villous atrophy associated with gross of intra-epithelial lymphocytosis. A gluten-free diet initiated in five patients led to clinical improvement in four cases with a follow-up of 8.25 months. The findings of this study in Djibouti show that celiac disease exists in intertropical Africa. Its presentation is quite similar to elsewhere but diagnosis is more difficult due to poor knowledge about the disease and limited diagnostic facilities. Favourable response to presumptive treatment by a gluten-free diet is an alternative for diagnosis especially in Djibouti where eating habits differ from those in industrialized countries and this type of diet is easier to follow.
authors.affiliation: Service de Médecine, Groupement Médico-Chirurgical Bouffard, Djibouti. thierrycoton@msn.com
authors.forename: T
authors.initials: T
authors.lastname: Coton
authors.forename: F
authors.initials: F
authors.lastname: Grassin
authors.forename: J
authors.initials: J
authors.lastname: Maslin
authors.forename: S
authors.initials: S
authors.lastname: Gidenne
authors.forename: D
authors.initials: D
authors.lastname: Sarret
authors.forename: F
authors.initials: F
authors.lastname: Petitjeans
authors.forename: A
authors.initials: A
authors.lastname: Benois
authors.forename: P
authors.initials: P
authors.lastname: Kraemer
authors.forename: G
authors.initials: G
authors.lastname: Cloatre
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D002446:Celiac Disease / Q000175:diagnosis* / Q000178:diet therapy; D002648:Child; D002675:Child, Preschool; D018753:Diet, Protein-Restricted; D015730:Djibouti; D005260:Female; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D011503:Transglutaminases / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005983:Glutens; D011503:Transglutaminases