title: Chromatin switching and transcriptional regulation in disease.
abstract: Many human diseases are the result of inappropriate changes in gene expression resulting in deleterious phenotypes of specific cells. For example, loss of expression of tumour suppressors and/or ectopic expression of oncogenes underlie many cancers, a switch from an adult to a fetal gene-expression profile in cardiac myocytes results in cardiac hypertrophy and changes in the expression of many ion channel genes leads to a phenotypic switch from contractile to proliferative smooth muscle cells in vascular diseases such as neointimal hyperplasia and atherosclerosis. Understanding the molecular mechanisms responsible for these changes in gene expression is a major goal, in order to identify novel therapeutic targets.
authors.affiliation: Institute of Membrane and Systems Biology, University of Leeds, Leeds, UK.
authors.forename: Lezanne
authors.initials: L
authors.lastname: Ooi
authors.forename: Ian C
authors.initials: IC
authors.lastname: Wood
mesh_terms: D000107:Acetylation; D002843:Chromatin / Q000235:genetics*; D004194:Disease; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D008745:Methylation; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D002843:Chromatin