title: Regulator of G protein signaling-4 controls fatty acid and glucose homeostasis.
abstract: Circulating free fatty acids are a reflection of the balance between lipogenesis and lipolysis that takes place mainly in adipose tissue. We found that mice deficient for regulator of G protein signaling (RGS)-4 have increased circulating catecholamines, and increased free fatty acids. Consequently, RGS4-/- mice have increased concentration of circulating free fatty acids; abnormally accumulate fatty acids in liver, resulting in liver steatosis; and show a higher degree of glucose intolerance and decreased insulin secretion in pancreas. We show in this study that RGS4 controls adipose tissue lipolysis through regulation of the secretion of catecholamines by adrenal glands. RGS4 controls the balance between adipose tissue lipolysis and lipogenesis, secondary to its role in the regulation of catecholamine secretion by adrenal glands. RGS4 therefore could be a good target for the treatment of metabolic diseases.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Unité 834, Montpellier F-34298, France.
authors.forename: Irena
authors.initials: I
authors.lastname: Iankova
authors.forename: Carine
authors.initials: C
authors.lastname: Chavey
authors.forename: Cyrielle
authors.initials: C
authors.lastname: Clapé
authors.forename: Claude
authors.initials: C
authors.lastname: Colomer
authors.forename: Nathalie C
authors.initials: NC
authors.lastname: Guérineau
authors.forename: Nicolas
authors.initials: N
authors.lastname: Grillet
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Brunet
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Annicotte
authors.forename: Lluis
authors.initials: L
authors.lastname: Fajas
mesh_terms: D041721:3T3-L1 Cells; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D004036:Diet, Atherogenic; D005215:Fasting / Q000097:blood; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism*; D005234:Fatty Liver / Q000150:complications / Q000235:genetics; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis / Q000235:genetics*; D006943:Hyperglycemia / Q000150:complications / Q000235:genetics; D006946:Hyperinsulinism / Q000150:complications / Q000235:genetics; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050155:Lipogenesis / Q000235:genetics; D008066:Lipolysis / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D020710:RGS Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: D005227:Fatty Acids; D007328:Insulin; D020710:RGS Proteins; C098799:RGS4 protein; D005947:Glucose