Localization of transient receptor potential vanilloid (TRPV) in the human larynx.
CONCLUSIONS
Transient receptor potential vanilloid (TRPV) 1, 2, 3, and 4 were expressed in the human larynx, which may act as laryngeal nociceptors perceiving luminal noxious stimuli, play an important role in thermal sensation and osmotic sensation, and are also related to some pathological conditions and prevention of aspiration.


OBJECTIVE
Expression of TRPV1, 2, 3, and 4 in the human larynx was analyzed.


METHODS
Specimens of human epiglottic epithelium obtained from six patients were used in this study. The localization of TRPV1, 2, 3, and 4 in the laryngeal epithelium was investigated by immunohistochemistry.


RESULTS
Immunohistochemical study revealed the presence of TRPV1, 2, 3, and 4 in the laryngeal epithelial cells. Chemoradiotherapy may reduce the expression of TRPV1, 2, 3, and 4, which might be a result of the mucositis and neuropathy in laryngeal epithelium.
Hamamoto
Takao
T
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. hamamoto-takao@ams.odn.ne.jp
Takumida
Masaya
M
Hirakawa
Katsuhiro
K
Tatsukawa
Takaharu
T
Ishibashi
Takuya
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D004847:Epithelial Cells / Q000737:chemistry; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D007825:Laryngectomy; D007830:Larynx / Q000737:chemistry* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D050916:TRPV Cation Channels / Q000032:analysis*; D014018:Tissue Distribution
D050916:TRPV Cation Channels; C494484:TRPV1 receptor; C400769:TRPV2 protein, human; C459445:TRPV3 protein, human; C416986:TRPV4 protein, human