Direct acylation of aryl bromides with aldehydes by palladium catalysis.
A new protocol for the direct acylation of aryl bromides with aldehydes is established. It appears to involve palladium-amine cooperative catalysis, affording synthetically important alkyl aryl ketones in moderate to excellent yields in a straightforward manner, and broadening the scope of metal-catalyzed coupling reactions.
Ruan
Jiwu
J
Department of Chemistry, Liverpool Centre for Materials and Catalysis, University of Liverpool, Liverpool L69 7ZD, UK.
Saidi
Ourida
O
Iggo
Jonathan A
JA
Xiao
Jianliang
J
D000215:Acylation; D000447:Aldehydes / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*
D000447:Aldehydes; D001965:Bromides; D010165:Palladium