title: [A case of primary breast cancer who responded remarkably to the neoadjuvant chemotherapy with the combination of docetaxel and cyclophosphamide].
abstract: A 67-year-old woman visited our hospital with suspicion of right breast cancer. She underwent core needle biopsy, and her disease was diagnosed as breast cancer (invasive ductal carcinoma, ER- and PgR- positive, HER2-negative). We chose neoadjuvant chemotherapy, because the tumor size was over 3 cm in diameter and she wished to conserve her breast. She was elderly, and so without anthracycline base, we used a combination of docetaxel (75 mg/m(2)) and cyclophosphamide (600 mg/m(2)) q3w 6 cycles followed by breast-conserving therapy. During treatment, the patient remained very well and showed no major side effects except grade 4 neutropenia on an outpatient basis. After 6 cycles, ultrasonography and mammography indicated the residual tumor, but breast MRI did not detect any tumor. Pathological examination showed absence of invasive tumor or only focal residual tumor cells (QpCR). We concluded that the combination of docetaxel and cyclophosphamide was a good option for neoadjuvant chemotherapy for early breast cancer.
authors.affiliation: Dept. of Surgery (Breast Surgery), Kyoto University Hospital.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshibayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishiguro
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takada
authors.forename: Megumi
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Yamashiro
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ueno
authors.forename: Hironori
authors.initials: H
authors.lastname: Kato
authors.forename: Kiyotsugu
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Shotaro
authors.initials: S
authors.lastname: Kanao
authors.forename: Chikako
authors.initials: C
authors.lastname: Yamauchi
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Mikami
authors.forename: Masakazu
authors.initials: M
authors.lastname: Toi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003520:Cyclophosphamide / Q000627:therapeutic use*; D000077143:Docetaxel; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D020360:Neoadjuvant Therapy; D043823:Taxoids / Q000627:therapeutic use*
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D003520:Cyclophosphamide