Double decarboxylative Claisen rearrangement reactions: microwave-assisted de novo synthesis of pyridines.
Microwave-assisted double decarboxylative Claisen rearrangement of bis(allyl) 2-tosylmalonates provides substituted 1,6-heptadienes, which may be alkylated, and then converted into pyridines by ozonolysis followed by reaction with ammonia generated in situ under microwave conditions.
Craig
Donald
D
Department of Chemistry, Imperial College London, South Kensington Campus, London, UK. d.craig@imperial.ac.uk
Paina
Federica
F
Smith
Stephen C
SC