Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives.
Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning). We identified abnormally reduced activation of several cortical regions, including the lateral orbitofrontal cortex, during reversal learning in OCD patients and their clinically unaffected close relatives, supporting the existence of an underlying previously undiscovered endophenotype for this disorder.
Chamberlain
Samuel R
SR
Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Box 189, Cambridge CB2 0QQ, UK. srchamb@gmail.com
Menzies
Lara
L
Hampshire
Adam
A
Suckling
John
J
Fineberg
Naomi A
NA
del Campo
Natalia
N
Aitken
Mike
M
Craig
Kevin
K
Owen
Adrian M
AM
Bullmore
Edward T
ET
Robbins
Trevor W
TW
Sahakian
Barbara J
BJ
D000328:Adult; D001931:Brain Mapping; D005190:Family; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology; D012193:Reversal Learning