[Peritoneal dialysis and insulin resistance in patients with chronic kidney disease due to nondiabetic nephropathy].
Significance of insulin resistance in patients with preserved renal function is currently well known. Disorders and clinical syndromes connected with insulin resistance in patients with chronic renal failure are broadly described in literature. Clinical significance of insulin resistance in patients with chronic renal failure treated with renal replacement therapy is still insufficiently explained and require more studies. Literature data indicate that long-term renal replacement treatment promotes development of insulin resistance. Furthermore it was proved, that insulin resistance in this group of patients is a strong independent predictor of mortality due to cardiovascular reasons. In patients treated with peritoneal dialysis, a potential risk factor of insulin resistance is persistent glucose overload, used as an osmotic agent in dialysis fluids. Insulin resistance as a potential agent of cardiovascular risk should be considered as a therapeutic target in patients undergoing peritoneal dialysis.
Wesołowski
Piotr
P
Wojskowy Instytut Medyczny w Warszawie, CSK MON, Klinika Chorób Wewnetrznych, Nefrologii i Dializoterapii, Poland. pwesol@amwaw.edu.pl
Saracyn
Marek
M
Nowak
Zbigniew
Z
Wańkowicz
Zofia
Z
D001786:Blood Glucose; D006801:Humans; D007333:Insulin Resistance; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D010530:Peritoneal Dialysis; D012307:Risk Factors
D001786:Blood Glucose