Synthesis and structure characterization of new 1,2,4-oxadiazolo[4,5-d]-1,5-benzothiazepines derivatives containing 2-phenyl-1,2,3-triazole through 1,3-dipolar cycloaddition reaction.
Reaction of 1,5-benzothiazepines, containing 2-phenyl-1,2,3-triazole 2a-d, with aryl nitrile oxides in CH2 Cl2 at room temperature leads to a series of novel 1,2,4-oxadiazolo[4,5-d]-1,5-benzothiazepine derivatives 3a-l in good yields. The products were characterized by IR, 1H NMR, MS, elemental analyses, X-ray and their spectrum characters were discussed.
Yang
De-Bao
DB
College of Materials and Chemical Engineering, Hangzhou Normal University, Hangzhou, 310036, China. baodeyang@163.com
Liu
Fang-Ming
FM
Xu
Feng
F
Yang
Chun
C
Ye
Jia-Wei
JW
Shen
Song-Wei
SW
Zhou
Ying-Lei
YL
Li
Wei
W
D018360:Crystallography, X-Ray; D003500:Cyclization; D013841:Thiazepines / Q000138:chemical synthesis* / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry*
C106746:1,5-benzothiazepine; D013841:Thiazepines; D014230:Triazoles