title: Lack of prognostic significance of "classic" lobular breast carcinoma: a matched, single institution series.
abstract: Whether invasive lobular carcinoma of the breast per se constitutes a prognostically favorable type has been debated. The present series comprises 301 consecutive "classic" lobular breast carcinomas seen at one institution between 1994 and 2001, compared to an equal number of invasive ductal carcinomas at the same institution during the same period, matched for year of surgery, age, menopausal status, primary tumor size, nodal involvement, hormone receptor status and where possible histological grade. Despite matching, the lobular carcinomas were more frequently multifocal, had more involved nodes, lower grade and lower proliferative fraction. There was no significant difference in disease-free or overall survival, locoregional relapse or time to distant metastasis between the lobular and ductal groups overall or within any examined subset, though the lobular group showed a trend to earlier appearance of contralateral breast cancer. Classical lobular histology is not an independent factor in the prognosis of early breast cancer.
authors.affiliation: European Institute of Oncology, University of Milan, Italy. giuseppe.viale@ieo.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Viale
authors.forename: Nicole
authors.initials: N
authors.lastname: Rotmensz
authors.forename: Patrick
authors.initials: P
authors.lastname: Maisonneuve
authors.forename: Enrico
authors.initials: E
authors.lastname: Orvieto
authors.forename: Eugenio
authors.initials: E
authors.lastname: Maiorano
authors.forename: Viviana
authors.initials: V
authors.lastname: Galimberti
authors.forename: Alberto
authors.initials: A
authors.lastname: Luini
authors.forename: Marco
authors.initials: M
authors.lastname: Colleoni
authors.forename: Aron
authors.initials: A
authors.lastname: Goldhirsch
authors.forename: Alan S
authors.initials: AS
authors.lastname: Coates
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000401:mortality / Q000473:pathology; D018275:Carcinoma, Lobular / Q000401:mortality* / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models