De novo autoimmunity after organ transplantation: targets and possible pathways.
The development of autoantibodies to different tissue-specific antigens in patients without existing history of autoimmune diseases suggests that autoimmunity may develop de novo after organ transplantation. In addition to allo-specific immune responses, tissue-specific autoimmunity also appears contribute to the host anti-graft response, and thus may affect long-term graft function. As graft failure caused by chronic rejection is a major challenge in clinical transplantation, understanding de novo autoreactivity after transplantation has important ramifications. This review investigates this emerging concept by discussing target antigens and possible pathways.
Boros
Peter
P
Recanati/Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY, USA.
Bromberg
Jonathan S
JS
D000818:Animals; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D015551:Autoimmunity; D006084:Graft Rejection / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology; D006801:Humans; D009928:Organ Specificity; D016377:Organ Transplantation; D014181:Transplantation Immunology
D001324:Autoantigens; D006360:Heat-Shock Proteins