title: Safety and long-term outcome of a new concept for surgical adhesion-reduction strategies (Prevadh): a prospective, multicenter study.
abstract: OBJECTIVE
  No agent has been consistently effective in preventing formation of peritoneal adhesions and postoperative bowel obstruction after abdominal surgery. The aim of this prospective multicenter study was to assess clinical safety and efficiency of a new adhesion-reduction barrier
  
  
  METHODS
  Between September 2000 and April 2001, Prevadh was used in 78 patients. Operative procedures included 25 hepatic resections, 7 cholecystectomies, 32 colonic resections, 7 protectomies, 3 colostomy or recovery of continuity, 1 gynaecologic surgery and 3 others. Eleven patients were operated on by laparoscopy and 67 by laparotomy.
  
  
  RESULTS
  The overall incidence of abscesses and wound complications was 2.4% and 9% respectively. After a mean follow-up of 36 months (range: 4-51 months), no patients experienced adverse events related to the adhesion barrier. Surgical reoperative procedures were performed in 10 patients for unrelated causes and no bowel obstruction occurred within the protected area.
  
  
  CONCLUSIONS
  This study confirmed the safety of Prevadh adhesion barrier and suggested that this resorbable barrier might provide prevention from adhesion formation on peritoneal injured surfaces. However, a large randomized controlled trial remains necessary to prove the real effectiveness of adhesion barriers on clinical long-term outcome.
authors.affiliation: Hôpital de la Croix-Rousse, Lyon, France.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Mabrut
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Favre
authors.forename: Bruno
authors.initials: B
authors.lastname: Desrousseaux
authors.forename: Jacques
authors.initials: J
authors.lastname: Chipponi
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Arnaud
authors.forename: Jacques
authors.initials: J
authors.lastname: Domergue
authors.forename: J P
authors.initials: JP
authors.lastname: Duffas
authors.forename: Gilles
authors.initials: G
authors.lastname: Fourtanier
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Flament
authors.forename: Christian
authors.initials: C
authors.lastname: Gouillat
authors.forename: Stéphane
authors.initials: S
authors.lastname: Berdah
authors.forename: Georges
authors.initials: G
authors.lastname: Mantion
authors.forename: Pierre-Louis
authors.initials: PL
authors.lastname: Fagniez
authors.forename: Gérard
authors.initials: G
authors.lastname: Champault
authors.forename: Jacques
authors.initials: J
authors.lastname: Baulieux
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013526:Surgical Mesh; D013997:Time Factors; D000267:Tissue Adhesions / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials