title: Functional depletion of capsaicin-sensitive primary afferent fibers attenuates rat pain-related behaviors and paw edema induced by the venom of scorpion Buthus martensi Karch.
abstract: The role of capsaicin-sensitive primary afferent fibers in rat pain-related behaviors and paw edema induced by scorpion Buthus martensi Karch (BmK) venom was investigated in this study. It was found that functional depletion of capsaicin-sensitive primary afferent fibers with a single systemic injection of resiniferatoxin (RTX) dramatically decreased spontaneous nociceptive behaviors, prevented the development of primary mechanical and thermal hyperalgesia as well as mirror-image mechanical hyperalgesia. RTX treatment significantly attenuated BmK venom-induced c-Fos expression in all laminaes of bilateral L4-L5 lumbar spinal cord, especially in superficial laminaes. Moreover, RTX treatment markedly reduced the early paw edema induced by BmK venom. Thus, the results indicate that capsaicin-sensitive primary afferent fibers play a critical role in various pain-related behaviors and paw edema induced by BmK venom in rats.
authors.affiliation: College of Life Sciences, Yanan University, Yanan 716000, PR China.
authors.forename: Zhan-Tao
authors.initials: ZT
authors.lastname: Bai
authors.forename: Tong
authors.initials: T
authors.lastname: Liu
authors.forename: Xue-Yan
authors.initials: XY
authors.lastname: Pang
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
authors.forename: Ming
authors.initials: M
authors.lastname: Cheng
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Ji
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000378:metabolism*; D004224:Diterpenes / Q000494:pharmacology; D004487:Edema / Q000503:physiopathology*; D006614:Hindlimb; D006930:Hyperalgesia / Q000503:physiopathology; D007150:Immunohistochemistry; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D017288:Pain Threshold; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012604:Scorpion Venoms / Q000009:adverse effects*; D013116:Spinal Cord / Q000378:metabolism
chemical_list: D004224:Diterpenes; D016760:Proto-Oncogene Proteins c-fos; D012604:Scorpion Venoms; C024353:resiniferatoxin; D002211:Capsaicin