[A case of interstitial pneumonia induced by S-1/irinotecan combination therapy].
A 67-year-old man with multiple liver metastases of colonic cancer was treated with combination therapy of S-1 and irinotecan (CPT-11): S-1 (120 mg/day) administered orally for 14 consecutive days followed by 14 days rest. CPT-11 (100 mg/m(2)) was given as a 2-hour infusion on day 1 and 15. The patient complained of high fever and subsequent exertional dyspnea in the middle of the second course of S-1/CPT-11 therapy. He was hospitalized with severe hypoxemia. CT scan showed extensive ground glass and consolidative changes in bilateral lungs. Steroid pulse therapy with oxygen therapy remarkably improved his symptoms, and abnormal findings on CT scan also resolved. Drug-induced pneumonia needs to be considered in the differential diagnosis when patients treated with S-1/CPT-11 combination therapy present high fever and dyspnea.
Aoki
Yukari
Y
Dept. of Hospital Pharmacy, Nagoya Memorial Hospital.
Kojima
Shinobu
S
Kataoka
Takae
T
Nagao
Seiji
S
Kayukawa
Satoshi
S
Mori
Fumiko
F
Masaki
Ayako
A
Yamada
Katsuyasu
K
Kawai
Masaru
M
Kabeya
Megumi
M
Hibi
Satoshi
S
Furuta
Ryuichi
R
Ina
Kenji
K
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use*; D002166:Camptothecin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D004338:Drug Combinations; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D010094:Oxonic Acid / Q000009:adverse effects* / Q000627:therapeutic use*; D005641:Tegafur / Q000009:adverse effects* / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure
D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000077146:Irinotecan; D002166:Camptothecin