title: The convenient synthesis and evaluation of the anticancer activities of new resveratrol derivatives.
abstract: In the present study we report the simple synthesis and antitumour activity of novel stilbene derivatives 13-22. The key synthetic strategies involved Wadsworth-Horner-Emmons condensation and coupling reactions in high yields. All compounds showed significant growth inhibition on human tumour cell lines, with the most potent compound (19) exhibiting an IC(50) of 5.7 microM-11.4 microM in vitro.
authors.affiliation: Department of Neuroscience and, Inam Neuroscience Research Center, Sanbon Medical Center, Wonkwang University, Kyunggido, South Korea.
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
authors.forename: Ill-Min
authors.initials: IM
authors.lastname: Chung
authors.forename: Jae-Chul
authors.initials: JC
authors.lastname: Jung
authors.forename: Eunyoung
authors.initials: E
authors.lastname: Lim
authors.forename: Yongnam
authors.initials: Y
authors.lastname: Lee
authors.forename: Seikwan
authors.initials: S
authors.lastname: Oh
authors.forename: Mankil
authors.initials: M
authors.lastname: Jung
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D000077185:Resveratrol; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; D000077185:Resveratrol