title: Advancing dental implant surface technology--from micron- to nanotopography.
abstract: Current trends in clinical dental implant therapy include use of endosseous dental implant surfaces embellished with nanoscale topographies. The goal of this review is to consider the role of nanoscale topographic modification of titanium substrates for the purpose of improving osseointegration. Nanotechnology offers engineers and biologists new ways of interacting with relevant biological processes. Moreover, nanotechnology has provided means of understanding and achieving cell specific functions. The various techniques that can impart nanoscale topographic features to titanium endosseous implants are described. Existing data supporting the role of nanotopography suggest that critical steps in osseointegration can be modulated by nanoscale modification of the implant surface. Important distinctions between nanoscale and micron-scale modification of the implant surface are presently considered. The advantages and disadvantages of nanoscale modification of the dental implant surface are discussed. Finally, available data concerning the current dental implant surfaces that utilize nanotopography in clinical dentistry are described. Nanoscale modification of titanium endosseous implant surfaces can alter cellular and tissue responses that may benefit osseointegration and dental implant therapy.
authors.affiliation: Universidade Católica de Brasília, Pós-Graduação em Ciências Genômicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte 70.790-160 Brasília, DF, Brazil. gmendonca@ufu.br
authors.forename: Gustavo
authors.initials: G
authors.lastname: Mendonça
authors.forename: Daniela B S
authors.initials: DB
authors.lastname: Mendonça
authors.forename: Francisco J L
authors.initials: FJ
authors.lastname: Aragão
authors.forename: Lyndon F
authors.initials: LF
authors.lastname: Cooper
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002448:Cell Adhesion / Q000502:physiology; D015921:Dental Implants; D017267:Dental Prosthesis Design; D006801:Humans; D008422:Materials Testing; D036103:Nanotechnology; D016348:Osseointegration; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D015921:Dental Implants