Long-term management of generalized pustular psoriasis with infliximab: case series.
BACKGROUND
Infliximab, a tumor necrosis factor alpha antagonist, has recently been shown to be successful for the short-term treatment of generalized pustular psoriasis (GPP) in multiple case reports.


OBJECTIVE
The goal of this case series was to assess the efficacy of the longer-term management of GPP with infliximab.


METHODS
Three patients with severe GPP were followed to assess the efficacy of long-term treatment with infliximab.


RESULTS
Infliximab therapy was more efficacious with infusion every 6 to 8 weeks in combination with methotrexate.


CONCLUSIONS
Infliximab may be efficacious for some patients for the long-term management of GPP. Maintaining a strict infliximab infusion schedule and concomitant methotrexate therapy may decrease infusion reactions and increase efficacy.
Routhouska
Shannon B
SB
Department of Dermatology, Murdough Family Center for Psoriasis, University Hospitals of Cleveland, Case Medical Center, Cleveland, OH, USA.
Sheth
Pranav B
PB
Korman
Neil J
NJ
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000069285:Infliximab; D007262:Infusions, Intravenous; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy*
D000911:Antibodies, Monoclonal; D003879:Dermatologic Agents; D000069285:Infliximab; D008727:Methotrexate