title: Primary vocal cord aspergillosis caused by Aspergillus fumigatus and molecular identification of the isolate.
abstract: This is a case of vocal cord aspergillosis in a 36-year-old woman whose chief complaint was progressive hoarseness and vocal fatigue of one month duration. These symptoms followed the use of systemic administration of penicillin, cefotaxime natrium and dexamethasone to treat her rhinitis and asthma. Fiberoptic laryngoscopy revealed whitish plaques involving both vocal cords. Microscopic examination of KOH preparations and histopathology studies of tissue revealed dichotomously branching, hyaline, septate hyphae. Morphological and molecular biological identification of the fungal growth in cultures inoculated with clinical specimens from the patient indicated that the etiologic agent was Aspergillus fumigatus. The patient was cured with oral itraconazole without any side effects.
authors.affiliation: Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, P. R. China. ranyuping@vip.sina.com
authors.forename: Yuping
authors.initials: Y
authors.lastname: Ran
authors.forename: Baiyan
authors.initials: B
authors.lastname: Yang
authors.forename: Suling
authors.initials: S
authors.lastname: Liu
authors.forename: Yaling
authors.initials: Y
authors.lastname: Dai
authors.forename: Zongguo
authors.initials: Z
authors.lastname: Pang
authors.forename: Jiayu
authors.initials: J
authors.lastname: Fan
authors.forename: Haoru
authors.initials: H
authors.lastname: Bai
authors.forename: Shixi
authors.initials: S
authors.lastname: Liu
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000382:microbiology* / Q000473:pathology*; D001232:Aspergillus fumigatus / Q000145:classification* / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification*; D001249:Asthma / Q000150:complications* / Q000188:drug therapy; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007828:Laryngoscopy; D012220:Rhinitis / Q000150:complications* / Q000188:drug therapy; D014827:Vocal Cords / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D017964:Itraconazole; D003907:Dexamethasone