title: The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation.
abstract: Corticosterone facilitates hippocampal glutamate transmission, but the cellular pathways by which AMPA receptor (AMPAR) signaling is adjusted remain elusive. Single quantum-dot imaging in live rat hippocampal neurons revealed that corticosterone triggers, via distinct corticosteroid receptors, time-dependent increases in GluR2-AMPAR surface mobility and synaptic surface GluR2 content. Furthermore, corticosterone potentiates the increase of synaptic surface GluR2 contents by a chemical long-term potentiation stimulus, revealing the influence that corticosterone has on AMPAR trafficking.
authors.affiliation: Physiologie Cellulaire de Synapse, UMR 5091 CNRS, Université Bordeaux 2, Bordeaux 33077, France. laurent.groc@u-bordeaux2.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: Groc
authors.forename: Daniel
authors.initials: D
authors.lastname: Choquet
authors.forename: Francis
authors.initials: F
authors.lastname: Chaouloff
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002478:Cells, Cultured; D003345:Corticosterone / Q000494:pharmacology / Q000502:physiology*; D004357:Drug Synergism; D018756:GABA Antagonists / Q000494:pharmacology; D005998:Glycine / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D021381:Protein Transport / Q000187:drug effects / Q000502:physiology; D045663:Quantum Dots; D051381:Rats; D018091:Receptors, AMPA / Q000378:metabolism*; D013268:Stimulation, Chemical; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
chemical_list: D018756:GABA Antagonists; D018091:Receptors, AMPA; C104722:glutamate receptor ionotropic, AMPA 2; D005998:Glycine; D003345:Corticosterone