The ups and downs of translation-dependent plasticity.
Neuroscientists have been looking for good examples linking neuronal activity to gene expression/regulation involved in synaptic plasticity and the formation of long-term memories. New findings from Park et al. and Waung et al. in this issue of Neuron show that fast dendritic translation of the immediate-early gene Arc/Arg3.1 is involved in hippocampal mGluR-LTD, a protein synthesis-dependent form of plasticity.
Castillo
Pablo E
PE
Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA. pcastill@aecom.yu.edu
Francesconi
Anna
A
Carroll
Reed C
RC
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology; D006624:Hippocampus / Q000166:cytology; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000502:physiology*