title: [Electrochemical behaviour of the adriamycin on the cobalt nanoparticles modified ITO electrode].
abstract: A cobalt nanoparticles modified ITO electrode (NpCo/ITO) was prepared by casting cobalt nanoparticles onto ITO electrode and the cobalt nanoparticles were synthesized by NaHB4 reduction. The electrochemical behaviors of adriamycin (ADM) on NpCo/ITO were studied. The modified ITO electrode was characterized by cyclic voltammetry (CV), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). In a 0.01 mol L(-1) PBS (pH 8.0) buffer solution, a sensitive reduction peak of ADM was obtained. A linear relationship is held between the peak current and ADM concentration in the range of 1.0 x 10(-8) - 2.0 x 10(-6) mol L(-1) with detection of 5.0 x 10(-9) mol L(-1)- by cyclic voltammetry (CV) response. The reduction process was irreversible with adsorption at the NpCo/ITO electrode. The modified electrode showed an excellent electrocatalytic activity for the ADM electrochemical reduction.
authors.affiliation: School of Life Science and Chemistry, Xinjiang Normal University, Urumchi 830054, China.
authors.forename: Lan-Xin
authors.initials: LX
authors.lastname: Gong
authors.forename: Cui-Mei
authors.initials: CM
authors.lastname: Wei
authors.forename: Jin-Bo
authors.initials: JB
authors.lastname: Hu
authors.forename: Qi-Long
authors.initials: QL
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D019411:Clinical Laboratory Techniques; D003035:Cobalt / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry* / Q000494:pharmacology; D004563:Electrochemistry; D004566:Electrodes / Q000639:trends*; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003035:Cobalt; D004317:Doxorubicin