title: The activity 'in vitro' of trospectomycin against high-level antibiotic-resistant enterococci.
abstract: Trospectomycin, a new aminocyclitol antibiotic, was uniformly active against 69 isolates of enterococci with high-level resistance to steptomycin (54 isolates), gentamicin (27 isolates), ampicillin (19 isolates), ciprofloxacin (17 isolates), vancomycin (3 isolates), or teicoplanin (3 isolates). In time-killing studies, trospectomycin alone demonstrated no bactericidal activity. No synergistic interaction was demonstrated when trospectomycin was combined with ampicillin, vacomycin or ciprofloxacin.
authors.affiliation: Servizio Aggregato di Consulenze Infettivologiche, Istituto di Clinica, Medica VI, Universita La Sapienza, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Venditti
authors.forename: A
authors.initials: A
authors.lastname: Tarasi
authors.forename: P
authors.initials: P
authors.lastname: Baiocchi
authors.forename: V
authors.initials: V
authors.lastname: Lamonaca
authors.forename: G P
authors.initials: GP
authors.lastname: Testore