title: Enhanced hype.
abstract: The recently published Effect of Combination Ezetimibe and High-Dose Simvastatin vs. Simvastatin Alone on the Atherosclerotic Process in Patients With Heterozygous Familial Hypercholesterolemia (ENHANCE) trial seems to raise questions regarding the notion that lipid lowering is of benefit in the prevention and treatment of vascular disease. Before one can make this conclusion, a careful analysis of the trial, including the subjects included and the surrogate end point studied, is required. The results of this study should be taken in context with those of many other studies showing that lipid lowering by many approaches is beneficial. In conclusion, the public fury over this study, with physicians making unsupported statements to the press and on the Web, is unfortunate and should be discouraged in the future.
authors.affiliation: Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. dharr02@emory.edu
authors.forename: David G
authors.initials: DG
authors.lastname: Harrison
authors.forename: W Virgil
authors.initials: WV
authors.lastname: Brown
authors.forename: Paolo
authors.initials: P
authors.lastname: Raggi
mesh_terms: D000280:Administration, Inhalation; D000924:Anticholesteremic Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D001384:Azetidines / Q000008:administration & dosage*; D004345:Drug Industry; D000069438:Ezetimibe; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy*; D033181:Information Dissemination; D019821:Simvastatin / Q000008:administration & dosage* / Q000627:therapeutic use*; D014481:United States
chemical_list: D000924:Anticholesteremic Agents; D001384:Azetidines; D019821:Simvastatin; D000069438:Ezetimibe