Cellular uptake and cytotoxicity of silica nanotubes.
"Template synthesized" silica nanotubes (SNTs) provide unique features such as end functionalization to control drug release, inner voids for loading biomolecules, and distinctive inner and outer surfaces that can be differentially functionalized for targeting and biocompatibility. Very limited information is available about their biological interactions. This work evaluates the influence of size and surface charge of SNTs on cellular toxicity and uptake. Results additionally indicate endocytosis to be one possible mechanism of internalization of SNTs.
Nan
Anjan
A
Center for Nanomedicine and Cellular Delivery, University of Maryland, Baltimore, Maryland, USA.
Bai
Xia
X
Son
Sang Jun
SJ
Lee
Sang Bok
SB
Ghandehari
Hamidreza
H
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003603:Cytotoxins / Q000378:metabolism* / Q000633:toxicity*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes / Q000633:toxicity* / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000378:metabolism* / Q000633:toxicity*
D003603:Cytotoxins; D012822:Silicon Dioxide