title: Cingulate gyral reductions are related to low executive functioning and psychotic symptoms in 22q 11.2 deletion syndrome.
abstract: A similar pattern of deficits in executive function and neuroanatomical abnormalities is shared between 22q 11.2 deletion syndrome (22q 11DS) and schizophrenia, suggesting that common cerebral alterations may lead to cognitive dysfunction and promote the appearance of psychotic symptoms in 22q 11DS individuals. Specifically, there is increasing evidence for involvement of the cingulate gyrus (CG) in executive dysfunction and the expression of positive symptoms in schizophrenia. The aim of our study is to examine CG morphology in a 22q 11DS population and its potential role as a cerebral marker of executive dysfunction and the manifestation of psychotic symptoms. Using region of interest (ROI)-based analysis, we compared CG volumes from 58 children and adults affected by 22q 11DS with 64 healthy age- and gender-matched controls. After covarying for total cranium grey matter and age, a bilateral reduced CG grey matter volume, driven by a decrease in anterior CG cortex, was observed among 22q 11DS patients. Further post hoc analyses suggest correlations between right CG cortical reductions, low-executive functioning and the occurrence of psychotic symptoms. The CG structural abnormalities observed in 22q 11DS are consistent with previous reports in schizophrenic patients and are associated with pre-morbid cognitive impairments. The mechanisms by which these changes may modulate executive functioning and the expression of psychosis are discussed.
authors.affiliation: Service Médico-Pédagogique Research Unit, Department of Psychiatry, University of Geneva School of Medicine, 1 rue David-Dufour, Case Postale 50, 1211 Geneva 8, Switzerland. federico.dufour@etat.ge.ch
authors.forename: Federico
authors.initials: F
authors.lastname: Dufour
authors.forename: Marie
authors.initials: M
authors.lastname: Schaer
authors.forename: Martin
authors.initials: M
authors.lastname: Debbané
authors.forename: Riaz
authors.initials: R
authors.lastname: Farhoumand
authors.forename: Bronwyn
authors.initials: B
authors.lastname: Glaser
authors.forename: Stephan
authors.initials: S
authors.lastname: Eliez
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D002648:Child; D003071:Cognition / Q000502:physiology*; D004062:DiGeorge Syndrome / Q000150:complications / Q000473:pathology* / Q000523:psychology; D005260:Female; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000473:pathology* / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D009929:Organ Size; D011618:Psychotic Disorders / Q000150:complications / Q000235:genetics / Q000473:pathology*; D012016:Reference Values; D018709:Statistics, Nonparametric