Genetic polymorphisms and the fate of the transplanted organ.
There has been an abundance of publications describing genetic variability in molecules affecting innate and adaptive immunity, pharmacogenetics, and other nonimmunological factors like the renin-angiotensin aldosterone system, coagulation, and fibrosis markers. Studies indicated some associations between polymorphisms in these candidate genes with outcomes in organ transplantation and underlined a potential role of genetic variability in transplantation. To be clinically applicable, large prospective studies must be performed to better define the potential benefits of genotyping on these genetic markers and clinical outcomes. The purposes of this review are to summarize recent data describing associations of polymorphisms in both immunological and nonimmunological molecules with transplant outcomes, with a particular emphasis on renal transplantation, and discuss limitations and clinical implications.
Krüger
Bernd
B
Division of Renal Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. bernd.kruger@mssm.edu
Schröppel
Bernd
B
Murphy
Barbara T
BT
D015815:Cell Adhesion Molecules / Q000235:genetics*; D002465:Cell Movement / Q000235:genetics; D018925:Chemokines / Q000235:genetics; D016207:Cytokines / Q000235:genetics*; D005819:Genetic Markers; D005838:Genotype; D006084:Graft Rejection / Q000235:genetics* / Q000276:immunology; D006085:Graft Survival / Q000235:genetics*; D006801:Humans; D007113:Immunity, Innate; D016030:Kidney Transplantation / Q000276:immunology*; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000235:genetics
D015815:Cell Adhesion Molecules; D018925:Chemokines; D016207:Cytokines; D005819:Genetic Markers