title: The safety of cefepime in the treatment of infection.
abstract: BACKGROUND
  Cefepime is a fourth-generation cephalosporin usually reserved for treating severe nosocomial pneumonia, as well as empirical treatment of febrile neutropenia, uncomplicated and complicated urinary tract infections, uncomplicated skin and skin structure infections, and complicated intra-abdominal infections.
  
  
  OBJECTIVE
  Since reports of neurotoxic effects and of an all-cause mortality higher with cefepime than with comparators have created some concerns regarding its safety, this paper reviews data available in the PubMed database up to December 2007 on cefepime safety.
  
  
  METHODS
  Literature data from PubMed obtained by combining cefepime and safety, or cefepime and clinical trials, were examined.
  
  
  CONCLUSIONS
  Caution in the use of cefepime should be adopted until new evidence on cefepime safety is available.
authors.affiliation: University of Milan, Laboratory of Clinical Microbiology, Department of Preclinical Science, LITA Vialba, Via GB Grassi 74, 20157 Milan, Italy. lorenzo.drago@unimi.it
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Drago
authors.forename: Elena
authors.initials: E
authors.lastname: De Vecchi
mesh_terms: D001424:Bacterial Infections / Q000188:drug therapy*; D000077723:Cefepime; D002511:Cephalosporins / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000209:etiology
chemical_list: D002511:Cephalosporins; D000077723:Cefepime