title: [Study on adscription of drug constituents in Beagle dog plasma after intragastric administration with Jiangzhining extract].
abstract: OBJECTIVE
  To investigate the drug constituents in Beagle dog plasma after intragastric administration with Jiangzhining extract, which is a Chinese medicine prescription and it consisting of processed Radix Polygoni Multiflori, Fructus Crataegi, Semen Cassiae and Folium Nelumbinis.
  
  
  METHODS
  The drug constituents and their origin in Beagle dogs plasma were assigned by comparison of high-performance liquid chromatographic profiles, retention time and ultraviolet spectra of the drug-free plasma, plasma contained drug, Jiangzhining extract and the ingredients of crude drug.
  
  
  RESULTS
  Twenty-four components were detected after intragastric administration of Jiangzhining extract, among which eight compounds were the original components existed in Jiangzhining extract and sixteen compounds were likely to metabolites of the some chemical constituents in ingredients of crude drug.
  
  
  CONCLUSIONS
  Studies on the drug constituents and the metabolites in plasma after intragastric administration of Jiangzhining extract are useful to elucidate the effective substances of Jiangzhining prescription.
authors.affiliation: Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Fu-Gang
authors.initials: FG
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Ren-Bing
authors.initials: RB
authors.lastname: Shi
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D005260:Female; D008297:Male; D044967:Serum / Q000378:metabolism*; D013270:Stomach
chemical_list: D004365:Drugs, Chinese Herbal; C540314:Jiangzhining extract