Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties.
A new study on terphenyl and diaryl-isoxazole and -isoxazoline derivatives, maintaining a common 3-adamantyl-4-hydroxyphenyl moiety, has been conducted to find compounds with growth supporting and antiapoptotic properties. Unexpectedly, diphenyisoxazole derivatives bearing a nitro group replacing the carboxylic function have been found with the highest cell protective activity within the series, in complete and in serum-free conditions. Inhibition of apoptosis induced by daunorubicin has also been observed for the most active compound.
Simoni
Daniele
D
Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Ferrara, Italy. smd@unife.it
Rondanin
Riccardo
R
Baruchello
Riccardo
R
Rizzi
Michele
M
Grisolia
Giuseppina
G
Eleopra
Marco
M
Grimaudo
Stefania
S
Di Cristina
Antonietta
A
Pipitone
Maria Rosaria
MR
Bongiorno
Maria Rita
MR
Aricò
Mario
M
Invidiata
Francesco Paolo
FP
Tolomeo
Manlio
M
D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013730:Terphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D007555:Isoxazoles; D013730:Terphenyl Compounds