title: [Study of a relationship between a change in the urinary uracil value after a S-1 long-term administration and the recurrence of stomach cancer].
abstract: S-1 has been reported good results in the treatment of stomach cancer. However, a DPD activity change has also been reported as one of the causes for a recurrence though some recurrence cases observing a state of tumor being unchanged continuously for more than 1 year. Therefore the urinary uracil value, which could simply be predicted in the DPD activity at the time of a recurrence after having administered S-1 for a long-term, was measured. And the urinary uracil value was examined whether it could become an index of recurrence compared with a healthy 5-person example as reference. In the result, a monthly difference in change of the urinary uracil values of the reference was small. However, the urinary uracil values in patients who were administered S-1 more than 6 months but recurred, were significantly lower comparing with the healthy 5-person example. We concluded from this study that the change in DPD activity due to an induction of DPD by 5-FU and metastasis of cancer caused the recurrence and lower a urinary value. The urinary uracil value reflecting DPD activity of the whole body could be used as an index of recurrence at the time of long-term dosage of S-1. Furthermore, a measurement of the urinary uracil value seems to be promising for estimation and evaluation of the cure.
authors.affiliation: Dept. of Pharmacy, National Hospital Organization, Osaka Minami Medical Center.
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Morimoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsuji
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Shono
authors.forename: Isao
authors.initials: I
authors.lastname: Akiyama
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Fujita
authors.forename: Kenji
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Tabuse
mesh_terms: D000368:Aged; D004338:Drug Combinations; D005260:Female; D006262:Health; D006801:Humans; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage* / Q000627:therapeutic use*; D012008:Recurrence; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000652:urine*; D005641:Tegafur / Q000008:administration & dosage* / Q000627:therapeutic use*; D013997:Time Factors; D014498:Uracil / Q000652:urine*
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D014498:Uracil; D010094:Oxonic Acid