title: Carbon nanotubes and mesenchymal stem cells: biocompatibility, proliferation and differentiation.
abstract: The synergy of the unique properties of carbon nanotubes (CNT) with the remarkable potential of human mesenchymal stem cells (hMSC) provides an exciting opportunity for novel therapeutic modalities. However, little is known about the impact of CNT on hMSC behavior. We report the effect of CNT on hMSC renewal, metabolic activity, and differentiation. Furthermore, we tracked the intracellular movement of CNT through the cytoplasm to a nuclear location and assessed effects on cellular ultra structure.
authors.affiliation: National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Galway, Ireland.
authors.forename: Emma
authors.initials: E
authors.lastname: Mooney
authors.forename: Peter
authors.initials: P
authors.lastname: Dockery
authors.forename: Udo
authors.initials: U
authors.lastname: Greiser
authors.forename: Mary
authors.initials: M
authors.lastname: Murphy
authors.forename: Valerie
authors.initials: V
authors.lastname: Barron
mesh_terms: D001672:Biocompatible Materials / Q000378:metabolism*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002478:Cells, Cultured; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism*; D046529:Microscopy, Electron, Transmission; D037742:Nanotubes, Carbon / Q000648:ultrastructure
chemical_list: D001672:Biocompatible Materials; D037742:Nanotubes, Carbon