title: A study on the chemical constituents of Veratrum nigrum L. processed by rice vinegar.
abstract: One new steroid alkaloid, 12beta-hydroxylveratroylzygadenine (1) and four known compounds, verdine (2), jervine (3), veramarine (4), and veratroylzygadenine (5), have been isolated from the roots and rhizomes of Veratrum nigrum L. processed by rice vinegar. Their structures were established through a combined analysis of physicochemical properties and spectroscopic evidence. The assay results revealed that compounds 1, 4, and 5 exhibited cell toxicity against human HL-60 cells with IC50 values 52.67, 52.90, and 56.51 micromol/l, respectively.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Cong
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Wang
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Yi-Mei
authors.initials: YM
authors.lastname: Zeng
authors.forename: Chang-Da
authors.initials: CD
authors.lastname: Liu
authors.forename: Xian
authors.initials: X
authors.lastname: Li
mesh_terms: D019342:Acetic Acid / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D018517:Plant Roots / Q000737:chemistry; D014703:Veratrum / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D019342:Acetic Acid