title: Prostate carcinoma spatial distribution patterns in Chinese men investigated with systematic transperineal ultrasound guided 11-region biopsy.
abstract: OBJECTIVE
  To evaluate prostate cancer spatial distribution patterns with transperineal ultrasound navigated 11-region prostate biopsy template in a Chinese screening population.
  
  
  METHODS
  From May 2004 to December 2007, 215 patients with a median prostate-specific antigen (PSA) level of 21.0 ng/ml were diagnosed with prostate cancer through transperineal ultrasound guided 11-region template prostate biopsy at Peking Union Medical College Hospital. The characteristics of our sample cancer spatial distribution were assessed in relation with different PSA levels.
  
  
  RESULTS
  The mean positives for the cancer of regions 1-10 and region 11 (the apical region) were 61.2% vs. 66.4% in patients whose PSA > 20 ng/ml (P = 0.29), and 35.7% vs. 47.6% in patients with PSA <or= 20 ng/ml (P = 0.001). The positives for cancer contained within the anterior and posterior parts were 96.5% vs. 90.9% (P = 0.10) in patients with PSA > 20 ng/ml and 75.2% vs. 75.2% in patients with PSA <or= 20 ng/ml (P = 1.00).
  
  
  CONCLUSIONS
  The current study suggests that prostate carcinoma foci are more frequently localized in the apical region in patients with normal to moderately increased PSA. Special attention should be paid to the apical region during the selection process of biopsy regions for this group of patients.
authors.affiliation: Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Weigang
authors.initials: W
authors.lastname: Yan
authors.forename: Hanzhong
authors.initials: H
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Zhongming
authors.initials: Z
authors.lastname: Huang
authors.forename: Shi
authors.initials: S
authors.lastname: Rong
authors.forename: Ming
authors.initials: M
authors.lastname: Xia
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Ji
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001706:Biopsy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D014463:Ultrasonography
chemical_list: D017430:Prostate-Specific Antigen