Binding of a dinuclear ruthenium(ii) complex to the TAR region of the HIV-AIDS viral RNA.
Molecular modelling has identified a new RNA conformational feature created by the insertion of bulge residues into duplex regions that may act as a recognition site for small molecule binding, in particular for inert dinuclear ruthenium complexes.
Buck
Damian P
DP
School of Physical, Environmental and Mathematical Sciences, University College, University of New South Wales, Australian Defence Force Academy, Canberra, ACT 2600, Australia.
Spillane
Caitriona B
CB
Collins
J Grant
JG
Keene
F Richard
FR
D019380:Anti-HIV Agents / Q000737:chemistry*; D001483:Base Sequence; D001665:Binding Sites; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000235:genetics*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012367:RNA, Viral / Q000737:chemistry* / Q000378:metabolism; D017975:Ruthenium Compounds / Q000737:chemistry* / Q000378:metabolism
D019380:Anti-HIV Agents; D012367:RNA, Viral; D017975:Ruthenium Compounds