Mechanisms of procentriole formation.
The centrosome comprises a pair of centrioles and associated pericentriolar material, and it is the principal microtubule-organizing centre of most animal cells. Like the genetic material, the centrosome is duplicated once and only once during the cell cycle. Despite the fact that both doubling events are crucial for genome integrity, the understanding of the mechanisms governing centrosome duplication has lagged behind the fuller knowledge of DNA replication. Here, we review recent findings that provide important mechanistic insights into how a single procentriole forms next to each centriole once per cell cycle, thus ensuring that one centrosome becomes two.
Strnad
Petr
P
Swiss Institute for Experimental Cancer Research (ISREC), Swiss Federal Institute of Technology (EPFL), School of Life Sciences, Lausanne, Switzerland.
Gönczy
Pierre
P
D000818:Animals; D002453:Cell Cycle; D002502:Centrioles / Q000235:genetics / Q000378:metabolism*; D018385:Centrosome / Q000378:metabolism; D006801:Humans; D008870:Microtubules