title: Cytomegalovirus infection in the human placenta: maternal immunity and developmentally regulated receptors on trophoblasts converge.
abstract: During human pregnancy, CMV infects the uterine-placental interface with varied outcomes from fetal intrauterine growth restriction to permanent birth defects, depending on the level of maternal immunity and gestational age. Virus spreads from infected uterine blood vessels, amplifies by replicating in decidual cells, and disseminates to the placenta in immune complexes. Cytotrophoblasts--epithelial cells of the placenta--differentiate along two distinct pathways. In the first, cells fuse into syncytiotrophoblasts covering the surface of chorionic villi that transport substances from the maternal to fetal bloodstream. In the second, cells invade the uterine interstitium and blood vessels, remodel the vasculature and form anchoring villi. CMV initiates replication in cytotrophoblast progenitor cells of floating villi, whereas syncytiotrophoblasts are spared. This extraordinary pattern of focal infection in underlying cells hinges on virion receptors being upregulated as villous cytotrophoblasts begin to differentiate. Expression of developmentally regulated receptors could explain viral replication in spatially distinct maternal and fetal compartments. Reduced invasiveness of infected cells could impair remodeling of the uterine vasculature, restrict maternal blood flow and access of the fetus to nutrients causing intrauterine growth restriction.
authors.affiliation: Department of Cell and Tissue Biology, School of Dentistry, University of California San Francisco, 513 Parnassus, C-734, Box-0640, San Francisco, 94143, USA. lenore.pereira@ucsf.edu
authors.forename: L
authors.initials: L
authors.lastname: Pereira
authors.forename: E
authors.initials: E
authors.lastname: Maidji
mesh_terms: D003587:Cytomegalovirus / Q000254:growth & development*; D003586:Cytomegalovirus Infections / Q000473:pathology*; D005260:Female; D006801:Humans; D010920:Placenta / Q000821:virology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000473:pathology*; D011991:Receptors, Virus; D014327:Trophoblasts / Q000821:virology
chemical_list: D011991:Receptors, Virus