title: Effect of soft laser and bioactive glass on bone regeneration in the treatment of bone defects (an experimental study).
abstract: This study aimed to investigate the influence of low-power gallium-aluminium-arsenide (GaAlAs) laser [830 nm, continuous wave (CW), 40 mW and fluence 4 J/cm(2)] on the healing of surgically created bone defects in rats treated with bioactive glass graft material. Surgical bone defects were created in the mandibles of 36 Wistar rats divided into two groups, each consisting of 18 rats. Group I was treated with bioactive glass plus laser irradiation. Group II was treated with graft material only. The animals were killed at 4 weeks, 8 weeks and 12 weeks postoperatively for histological examination. Laser irradiation had significantly accelerated bone healing at 4 weeks and 8 weeks in comparison with that at the sites not irradiated. However at 12 weeks, complete healing of the defects had occurred with no difference detected. Our results have confirmed the positive effect of soft laser in accelerating bone regeneration.
authors.affiliation: Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
authors.forename: Nayer S
authors.initials: NS
authors.lastname: AboElsaad
authors.forename: Mena
authors.initials: M
authors.lastname: Soory
authors.forename: Laila M A
authors.initials: LM
authors.lastname: Gadalla
authors.forename: Laila I
authors.initials: LI
authors.lastname: Ragab
authors.forename: Stephen
authors.initials: S
authors.lastname: Dunne
authors.forename: Khaled R
authors.initials: KR
authors.lastname: Zalata
authors.forename: Chris
authors.initials: C
authors.lastname: Louca
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects* / Q000528:radiation effects*; D018786:Bone Substitutes; D001842:Bone and Bones / Q000187:drug effects / Q000293:injuries / Q000473:pathology / Q000528:radiation effects; D002516:Ceramics / Q000627:therapeutic use*; D048091:Guided Tissue Regeneration / Q000379:methods; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D028022:Low-Level Light Therapy; D016348:Osseointegration / Q000187:drug effects / Q000528:radiation effects; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects / Q000528:radiation effects
chemical_list: C022107:Bioglass; D018786:Bone Substitutes