Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1).
This study reports the identification and Hits to Leads optimization of inhibitors of coactivator associated arginine methyltransferase (CARM1). Compound 7b is a potent, selective inhibitor of CARM1.
Purandare
Ashok V
AV
Bristol-Myers Squibb Pharmaceutical Research and Development, Princeton, NJ 08543, USA. ashok.purandare@bms.com
Chen
Zhong
Z
Huynh
Tram
T
Pang
Suhong
S
Geng
Jieping
J
Vaccaro
Wayne
W
Poss
Michael A
MA
Oconnell
Jonathan
J
Nowak
Kimberly
K
Jayaraman
Lata
L
D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D011484:Protein-Arginine N-Methyltransferases / Q000037:antagonists & inhibitors*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D011720:Pyrazoles; D011484:Protein-Arginine N-Methyltransferases; C119966:coactivator-associated arginine methyltransferase 1