title: Anti-tubercular activity of ruthenium (II) complexes with polypyridines.
abstract: A series of nine polypyridyl-ruthenium (II) complexes (N-ligands = 2,2'-bipyridines; 2,2'-6',2'-terpyridines, di-alkyloxy-2,2'-6,2-bipyridine-3,3'-di-carboxylates), were tested against Mycobacterium tuberculosis (MBT). The complex (11) showed remarkable activity against MBT as compared to other complexes, (1-10). The aquo ligand of complex (11), as opposed to other chloro and acetonitrile derivatives, appears to play a key role in the antitubercular potency of this new class of metal-based compounds.
authors.affiliation: Laboratoire Chimie des Materiaux, Faculte des Sciences, Oujda, Morocco. tbenhadda@yahoo.fr
authors.forename: Taibi Ben
authors.initials: TB
authors.lastname: Hadda
authors.forename: Mehmet
authors.initials: M
authors.lastname: Akkurt
authors.forename: Mohamed Filali
authors.initials: MF
authors.lastname: Baba
authors.forename: Maria
authors.initials: M
authors.lastname: Daoudi
authors.forename: Brahim
authors.initials: B
authors.lastname: Bennani
authors.forename: Abdelali
authors.initials: A
authors.lastname: Kerbal
authors.forename: Zahid H
authors.initials: ZH
authors.lastname: Chohan
mesh_terms: D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology; D004563:Electrochemistry; D008024:Ligands; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000995:Antitubercular Agents; D008024:Ligands; D009942:Organometallic Compounds; D015082:2,2'-Dipyridyl; D012428:Ruthenium