title: Physico-chemical characterisation of lipids from Mytilus galloprovincialis (L.) and Rapana venosa and their healing properties on skin burns.
abstract: Black Sea molluscs and gastropods are the most studied organisms from the Romanian littoral zone. In particular, those from the Mytilidae species are of great interest because biochemical investigations have shown that they can be sources of biological active substances which can have different applications (e.g. food additives). We report here the extraction of lipids from two different species of molluscs (Mytilus galloprovincialis L., Mediterranean mussel) and gastropods (Rapana venosa, hard-shell clam). The extracts were evaluated in terms of antioxidant and composition properties and their healing properties were tested on skin burns in Wistar rats. Our studies proved that the two lipid extracts contained a relatively complex distribution of compounds, in terms of characteristic indices, polyunsaturated fatty acids (PUFA) and vitamins E and D. The presence of such compounds rendered the extracts very efficient in healing induced skin burns in Wistar rats. The histological analysis showed a reduction in the time of healing (12-13 and 13-15 days for the Mytilus galloprovincialis (L.) Rapana venosa extracts, respectively) compared to 20-22 for untreated animals, based on results from tissues and blood samples. Our investigations have been proved to be promising in terms of future potential applications of the extracts as skin-care products, cosmetics and/or pharmaceutical preparations owing to their dermorestitutive properties.
authors.affiliation: Department of Biology-Biochemistry, Faculty of Natural and Agricultural Sciences, Ovidius University of Constanza, Constanza, Romania. dianabadiu@yahoo.com
authors.forename: Diana L
authors.initials: DL
authors.lastname: Badiu
authors.forename: Alina M
authors.initials: AM
authors.lastname: Balu
authors.forename: Lucica
authors.initials: L
authors.lastname: Barbes
authors.forename: Rafael
authors.initials: R
authors.lastname: Luque
authors.forename: Roxana
authors.initials: R
authors.lastname: Nita
authors.forename: Marius
authors.initials: M
authors.lastname: Radu
authors.forename: Ecaterina
authors.initials: E
authors.lastname: Tanase
authors.forename: Natalia
authors.initials: N
authors.lastname: Rosoiu
mesh_terms: D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D008401:Gas Chromatography-Mass Spectrometry; D049851:Gastropoda / Q000737:chemistry; D008055:Lipids / Q000737:chemistry* / Q000627:therapeutic use*; D008297:Male; D049878:Mytilus / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000098:blood supply / Q000473:pathology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013057:Spectrum Analysis; D014945:Wound Healing / Q000187:drug effects
chemical_list: D005231:Fatty Acids, Unsaturated; D008055:Lipids