Benzo(a)pyrene-induced genotoxicity: attenuation by farnesol in a mouse model.
In the present study we have evaluated the antigenotoxic effects of Farnesol (FL) a 15-carbon isoprenoid alcohol against benzo (a) pyrene [B(a)P] (125 mg kg(- 1).b.wt oral) induced toxicity. B(a)P administration lead to significant induction in Cytochrome P450 (CYP) content and aryl hydrocarbon hydrolase (AHH) activity (p < 0.001), DNA strand breaks and DNA adducts (p < 0.001) formation. FL was shown to suppress the activities of both CYP and AHH (p < 0.005) in modulator groups. FL pretreatment significantly (p < 0.001) restored depleted levels of reduced glutathione (GSH), quinone reductase (QR) and glutathione -S-transferase (GST). A simultaneous significant and at both the doses reduction was seen in DNA strand breaks and in in-vivo DNA adducts formation (p < 0.005), which gives some insight on restoration of DNA integrity. The results support the protective nature of FL. Hence present data supports FL as a future drug to preclude B (a) P induced toxicity.
Jahangir
Tamanna
T
Section of Chemoprevention and Nutrition Toxicology, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110062, India.
Sultana
Sarwat
S
D000818:Animals; D001564:Benzo(a)pyrene / Q000737:chemistry* / Q000633:toxicity*; D018736:DNA Adducts / Q000235:genetics; D004249:DNA Damage; D005204:Farnesol / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D023421:Models, Animal; D015394:Molecular Structure
D018736:DNA Adducts; D001564:Benzo(a)pyrene; D005204:Farnesol