Cell competition and its possible relation to cancer.
Cell competition can occur when cells of different genotypes share the same developing compartment, with one genotype displacing the other as a result of a proliferative advantage. Studies of cell competition in Drosophila have identified an active process of cell assassination and corpse engulfment, and also roles for Myc and the Warts/Hippo tumor suppressor pathway. Here, we discuss the possible relevance of cell competition to cancer.
Baker
Nicholas E
NE
Department of Molecular Genetics, Albet Einstein College of Medicine, Bronx, New York 10461, USA. nbaker@aecom.yu.edu
Li
Wei
W
D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D022082:Cellular Structures; D004331:Drosophila melanogaster; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D005838:Genotype; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism
D016271:Proto-Oncogene Proteins c-myc