title: Left ventricular apical rotation is related to ambulatory blood pressure and body mass in healthy elderly females.
abstract: OBJECTIVE
  The interaction between left ventricular (LV) apical rotation, blood pressure (BP) and body mass in elderly females may reveal mechanisms involved in the syndrome of diastolic heart failure.
  
  
  METHODS
  Thirty-one healthy females, age 69-84 years, were studied with echocardiography, ambulatory BP and an exercise capacity (VO2peak) test.
  
  
  RESULTS
  LV apical short-axis loops were eligible for speckle tracking analysis in 27 subjects. Peak apical rotation (PAR) correlated inversely with diastolic BP (r = -0.47, p = 0.01). PAR correlated positively with stroke volume and body weight (p<0.05), but not with VO2peak (n = 19, p = ns). PAR also correlated with peak rotation velocity in systole (r = 0.76, p<0.0001) and in diastole (r = 0.58, p = 0.001). Diastolic peak rotation velocity correlated with mitral E wave peak velocity (r = 0.48, p = 0.01). There was a significant reduction in LV volumes during the 4 years of follow-up.
  
  
  CONCLUSIONS
  In healthy elderly females, there seems to be an interaction between LV apical rotation, BP and body mass. Peak apical rotation and peak diastolic rotation velocity correlate with indices of LV filling and ejection, indicating that suction, a crucial element for effective early LV filling, may be preserved in healthy elderly subjects. Suction deteriorates with elevations of the arterial BP. An age- and BP-related reduction in LV end-diastolic volume may represent an additional impediment to LV filling. Both features may contribute to the development of LV diastolic dysfunction and to episodes of diastolic heart failure.
authors.affiliation: Department of Cardiology St. Olavs University Hospital, Trondheim, Norway. soma_joh@yahoo.co
authors.forename: Johannes
authors.initials: J
authors.lastname: Soma
authors.forename: Ulrik
authors.initials: U
authors.lastname: Wisløff
authors.forename: Gjertrud Aunet
authors.initials: GA
authors.lastname: Tyldum
authors.forename: Inga Ekeberg
authors.initials: IE
authors.lastname: Schjerve
authors.forename: Ketil
authors.initials: K
authors.lastname: Dahl
authors.forename: Tor-Erik
authors.initials: TE
authors.lastname: Widerøe
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology; D018660:Blood Pressure Monitoring, Ambulatory; D015992:Body Mass Index; D004452:Echocardiography; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results; D012399:Rotation; D016277:Ventricular Function, Left / Q000502:physiology*