Analysis of alternative splicing in plants with bioinformatics tools.
Alternative splicing is a molecular mechanism utilized by a broad range of eukaryotes to extend the repertoire of functions encoded by single genes and to posttranscriptionally regulate gene expression. Recent analyses of expressed transcript sequences aligned to the complete genomes of Arabidopsis and rice indicate that alternative splicing in plants is prevalent and exhibits several features similar to other higher eukaryotes including mouse and human. This chapter reviews the computational strategies employed to study alternative splicing with bioinformatics tools and the recent findings from analyses performed on plants by applying such methods.
Haas
B J
BJ
B.J. Haas Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA. bhaas@broad.mit.edu
D017398:Alternative Splicing; D000818:Animals; D019295:Computational Biology / Q000379:methods; D017343:Genes, Plant; D014644:Genetic Variation; D010944:Plants / Q000235:genetics*