title: Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus.
abstract: The retrospective study of 34 patients with Hodgkin lymphoma-associated hemophagocytic syndrome led us to define this association as a specific disorder. Its characteristics are male predominance (male-to-female sex ratio, 3.3:1), immunodeficiency-like histological features (lymphocyte depletion, 45% of cases; mixed cellularity Hodgkin lymphoma subtype, 40%), and strong association with Epstein-Barr virus (94%).
authors.affiliation: Université Paris-Sud, F-94270, Paris, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Ménard
authors.forename: Caroline
authors.initials: C
authors.lastname: Besson
authors.forename: Patricia
authors.initials: P
authors.lastname: Rincé
authors.forename: Olivier
authors.initials: O
authors.lastname: Lambotte
authors.forename: Thierry
authors.initials: T
authors.lastname: Lazure
authors.forename: Danielle
authors.initials: D
authors.lastname: Canioni
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
authors.forename: Pierre
authors.initials: P
authors.lastname: Brousset
authors.forename: Antoine
authors.initials: A
authors.lastname: Martin
authors.forename: Philippe
authors.initials: P
authors.lastname: Gaulard
authors.forename: Martine
authors.initials: M
authors.lastname: Raphaël
authors.forename: Claire
authors.initials: C
authors.lastname: Larroche
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000150:complications* / Q000821:virology*; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged