title: Abnormal corpus callosum integrity in bipolar disorder: a diffusion tensor imaging study.
abstract: OBJECTIVE
  Abnormalities in the anterior interhemispheric connections provided by the corpus callosum (CC) have long been implicated in bipolar disorder (BD). In this study, we used complementary diffusion tensor imaging methods to study the structural integrity of the CC and localization of potential abnormalities in BD.
  
  
  METHODS
  Subjects included 33 participants with BD and 40 healthy comparison participants. Fractional anisotropy (FA) measures were compared between groups with region of interest (ROI) methods to investigate the anterior, middle, and posterior CC and voxel-based methods to further localize abnormalities.
  
  
  RESULTS
  In ROI-based analyses, FA was significantly decreased in the anterior and middle CC in the BD group (p < .05). Voxel-based analyses similarly localized group differences to the genu, rostral body, and anterior midbody of CC (p < .05, corrected).
  
  
  CONCLUSIONS
  The findings demonstrate abnormalities in the structural integrity of the anterior CC in BD that might contribute to altered interhemispheric connectivity in this disorder.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut. Electronic address: fei.wang@yale.edu.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut.
authors.forename: Jessica H
authors.initials: JH
authors.lastname: Kalmar
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut.
authors.forename: Elliot Kale
authors.initials: EK
authors.lastname: Edmiston
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut.
authors.forename: Lara G
authors.initials: LG
authors.lastname: Chepenik
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Zubin
authors.initials: Z
authors.lastname: Bhagwagar
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut.
authors.forename: Linda
authors.initials: L
authors.lastname: Spencer
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Brian
authors.initials: B
authors.lastname: Pittman
authors.affiliation: Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut; Institute of Mathematics and Statistics, University of São Paulo, Brazil.
authors.forename: Marcel
authors.initials: M
authors.lastname: Jackowski
authors.affiliation: Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut; Department of Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Xenophon
authors.initials: X
authors.lastname: Papademetris
authors.affiliation: Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut; Department of Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut; Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: R Todd
authors.initials: RT
authors.lastname: Constable
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut.
authors.forename: Hilary P
authors.initials: HP
authors.lastname: Blumberg
mesh_terms: D000328:Adult; D016880:Anisotropy; D001714:Bipolar Disorder / Q000473:pathology*; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values; D018709:Statistics, Nonparametric; D055815:Young Adult