title: Stenting of symptomatic basilar and vertebral artery stenosis in patients resistant to optimal medical prevention: the lyon stroke unit experience.
abstract: Intracranial angioplasty stenting may be an efficient therapy in patients with intracranial atherosclerotic symptomatic vertebrobasilar artery stenosis unresponsive to optimal medical therapy. We present our experience in this setting.
  
  
  RESULTS
  The study included 12 cases (8 men, 4 women), with an age range of 43-78 years (mean 62.6 years). Intracranial stenosis that resulted in qualifying stroke or transient ischemic attack involved the vertebral artery (n = 4), lower basilar artery (n = 1) and mid basilar artery (n = 5). Tandem stenosis included the intracranial vertebral artery and basilar artery (n = 1) and both intracranial vertebral arteries (n = 1). The degree of stenosis ranged between 70 and 90% in the basilar and vertebral arteries. Angioplasty + stenting was performed in all lesions. A successful procedure resulting in 30% of residual stenosis was found in 14 vessels. A periprocedural adverse event occurred in 1 case and was related to a brain hemorrhage. The mean patient follow-up was 15 +/- 3 months; 10 patients remained symptom free. All patients underwent a percutaneous endovascular balloon angioplasty and stent placement.
  
  
  CONCLUSIONS
  This study supports the safety and the potential efficiency of stent-assisted angioplasty in patients resistant to optimal prevention. Randomized larger prospective trials are needed to confirm the benefit of this approach.
authors.affiliation: Cerebrovascular Unit, Hôpital Neurologique Pierre-Wertheimer, Lyon, France.
authors.forename: Ionela-Camelia
authors.initials: IC
authors.lastname: Ralea
authors.forename: Norbert
authors.initials: N
authors.lastname: Nighoghossian
authors.forename: Florence
authors.initials: F
authors.lastname: Tahon
authors.forename: Laurent
authors.initials: L
authors.lastname: Derex
authors.forename: Serkan
authors.initials: S
authors.lastname: Cakmak
authors.forename: Paul
authors.initials: P
authors.lastname: Trouillas
authors.forename: Francis
authors.initials: F
authors.lastname: Turjman
mesh_terms: D000328:Adult; D000368:Aged; D000800:Angioplasty, Balloon / Q000009:adverse effects / Q000295:instrumentation*; D000925:Anticoagulants / Q000627:therapeutic use; D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015607:Stents; D020521:Stroke / Q000209:etiology / Q000601:surgery; D014715:Vertebrobasilar Insufficiency / Q000150:complications / Q000601:surgery*
chemical_list: D000925:Anticoagulants; D000960:Hypolipidemic Agents