Serum alpha-fetoprotein predicts virologic response to hepatitis C treatment in HIV coinfected patients.
We explored the link between serum alpha-fetoprotein levels and virologic response in 383 HIV-hepatitis C virus coinfected patients. A low alpha-fetoprotein level (<5.0 ng/ml) was an independent predictor of sustained virologic response (odds ratio = 1.83; 95% confidence interval 1.05-3.20). Serum alpha-fetoprotein measurement should be integrated in the pretreatment assessment of prognostic factors of a virologic response.
Carrat
Fabrice
F
UPMC-Paris6, UMR-S707, INSERM, UMR-S707, Saint-Antoine Hospital, Assistance Publique Hôpitaux de Paris, France. carrat@u707.jussieu.fr
Bedossa
Pierre
P
Lunel-Fabiani
Françoise
F
Morand
Patrice
P
Pialoux
Gilles
G
Piroth
Lionel
L
Salmon-Céron
Dominique
D
Bani-Sadr
Firouzé
F
Perronne
Christian
C
Cacoub
Patrice
P
Pol
Stanislas
S
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D008297:Male; D011092:Polyethylene Glycols; D011994:Recombinant Proteins; D012254:Ribavirin / Q000627:therapeutic use; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000378:metabolism*
D000998:Antiviral Agents; D015415:Biomarkers; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D000509:alpha-Fetoproteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C417083:peginterferon alfa-2b