title: Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives.
abstract: Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning). We identified abnormally reduced activation of several cortical regions, including the lateral orbitofrontal cortex, during reversal learning in OCD patients and their clinically unaffected close relatives, supporting the existence of an underlying previously undiscovered endophenotype for this disorder.
authors.affiliation: Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Box 189, Cambridge CB2 0QQ, UK. srchamb@gmail.com
authors.forename: Samuel R
authors.initials: SR
authors.lastname: Chamberlain
authors.forename: Lara
authors.initials: L
authors.lastname: Menzies
authors.forename: Adam
authors.initials: A
authors.lastname: Hampshire
authors.forename: John
authors.initials: J
authors.lastname: Suckling
authors.forename: Naomi A
authors.initials: NA
authors.lastname: Fineberg
authors.forename: Natalia
authors.initials: N
authors.lastname: del Campo
authors.forename: Mike
authors.initials: M
authors.lastname: Aitken
authors.forename: Kevin
authors.initials: K
authors.lastname: Craig
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Owen
authors.forename: Edward T
authors.initials: ET
authors.lastname: Bullmore
authors.forename: Trevor W
authors.initials: TW
authors.lastname: Robbins
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Sahakian
mesh_terms: D000328:Adult; D001931:Brain Mapping; D005190:Family; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology; D012193:Reversal Learning