[Caspases--a new target in inflammation and cancer therapy?].
The family of caspases - intracellular cysteine proteases - comprises enzymes engaged in inflammatory response or cell apoptosis. The activity of caspases is a determinant for the life span of many cells. Defects in activity of some members of the caspase family can be related to neurodegenerative disorders, autoimmune diseases and cancer. The current knowledge of the structure, substrate specificity and function of caspases encourages interfering with caspase signaling and to pharmacological manipulation of the cell apoptosis.
Korzeniewska-Dyl
Irmina
I
D017209:Apoptosis / Q000187:drug effects; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000201:enzymology; D061945:Caspase Inhibitors; D020169:Caspases / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000201:enzymology*; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000201:enzymology
D061945:Caspase Inhibitors; D020169:Caspases