title: [Long-acting medications for the treatment of hyperkinetic disorders - a systematic review and European treatment guidelines. Part 2: a quantitative evaluation of long-acting medications].
abstract: A panel of experts from several European countries has accomplished a systematic review of published and unpublished data on the use of long-acting medications in ADHD and hyperkinetic disorders, on the basis of which practical recommendations for the application of these medications have been developed. The current article outlines results of this analysis, comparing the effect sizes and numbers-needed to-treat for extended-release stimulant preparations and atomoxetine (ATX). It is concluded (1) that long-acting preparations should be licensed and used. (2) However, they should not completely replace short-acting medications, in view of costs as well as the greater flexibility of dosing. Individual choices of therapy are necessary. (3) Both ATX and retarded-release stimulants should be available.
authors.affiliation: Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters, Zentralinstitut für Seelische Gesundheit, Mannheim.
authors.forename: Tobias
authors.initials: T
authors.lastname: Banaschewski
authors.forename: David
authors.initials: D
authors.lastname: Coghill
authors.forename: Paramala
authors.initials: P
authors.lastname: Santosh
authors.forename: Alessandro
authors.initials: A
authors.lastname: Zuddas
authors.forename: Philip
authors.initials: P
authors.lastname: Asherson
authors.forename: Jan
authors.initials: J
authors.lastname: Buitelaar
authors.forename: Marina
authors.initials: M
authors.lastname: Danckaerts
authors.forename: Manfred
authors.initials: M
authors.lastname: Döpfner
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
authors.forename: Aribert
authors.initials: A
authors.lastname: Rothenberger
authors.forename: Joseph
authors.initials: J
authors.lastname: Sergeant
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Steinhausen
authors.forename: Edmund J S
authors.initials: EJ
authors.lastname: Sonuga-Barke
authors.forename: Eric
authors.initials: E
authors.lastname: Taylor
mesh_terms: D000662:Amphetamines / Q000008:administration & dosage / Q000009:adverse effects; D000069445:Atomoxetine Hydrochloride; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D000697:Central Nervous System Stimulants / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D003692:Delayed-Action Preparations; D005060:Europe; D019317:Evidence-Based Medicine; D006801:Humans; D008774:Methylphenidate / Q000008:administration & dosage / Q000009:adverse effects; D017410:Practice Guidelines as Topic; D011437:Propylamines / Q000008:administration & dosage / Q000009:adverse effects; D011788:Quality of Life / Q000523:psychology; D016896:Treatment Outcome
chemical_list: D000662:Amphetamines; D000697:Central Nervous System Stimulants; D003692:Delayed-Action Preparations; D011437:Propylamines; D008774:Methylphenidate; D000069445:Atomoxetine Hydrochloride