title: [Optimization of ligustrazine phosphate thermosensitive gel formulation by central composite design-response surface methodology].
abstract: OBJECTIVE
  To optimize the formulation of ligustrazine phosphate thermosensitive gel by the central composite design-response surface methodology (RSM plus CCD).
  
  
  METHODS
  In the formulation design using RSM plus CCD, independent variables were the amounts of poloxamer 407 and poloxamer 188, and gel temperature was dependent variable. Multilinear and quadratic models were used to estimate the relationship between the dependent and the independent variables, select the optimal formulations and validate.
  
  
  RESULTS
  The quantitative relationships between two factors and evaluation index were characterized, quadratic model had better prediction capability than multilinear model.
  
  
  CONCLUSIONS
  Quadratic model is performed in the optimization of formulation due to the statistical confidence. The optimization of ligustrazine phosphate thermosensitive gel formulation can be achieved by the central composite design and response surface methodology.
authors.affiliation: College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Meng
authors.forename: Yue-Hong
authors.initials: YH
authors.lastname: Xu
authors.forename: Ping-Tian
authors.initials: PT
authors.lastname: Ding
authors.forename: Yu-Jiao
authors.initials: YJ
authors.lastname: Deng
authors.forename: Min-Yan
authors.initials: MY
authors.lastname: Wei
mesh_terms: D000465:Algorithms; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D005782:Gels; D016014:Linear Models; D020442:Poloxamer / Q000737:chemistry*; D011719:Pyrazines / Q000008:administration & dosage* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature; D014783:Viscosity
chemical_list: D005782:Gels; D011719:Pyrazines; D020442:Poloxamer; C017953:tetramethylpyrazine