title: Hyperkeratosis of the nipple and areola: 2 years of remission with low-dose acitretin and topical calcipotriol therapy.
abstract: Hyperkeratosis of the nipple and areola is a rare disorder characterized by verrucous thickening and brown pigmentation of the nipple and areola with unknown etiology. Although it is a generally asymptomatic disorder, cosmetic disfiguring creates a real psychological problem for young women. Moreover, treatment regimens are not satisfactory. Surgical treatment has been suggested as an initial treatment in resistant and recurrent cases because of the relapses seen after medical treatment. We report a case who responded satisfactorily to low-dose acitretin and topical calcipotriol treatment with no relapses during 2 years of follow-up. Among all reported medical treatments and interventional approaches, including surgery, this is the first patient reported with 2 years of remission.
authors.affiliation: Dermatology Clinic, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. pelin@dr.com
authors.forename: Selda Pelin
authors.initials: SP
authors.lastname: Kartal Durmazlar
authors.forename: Fatma
authors.initials: F
authors.lastname: Eskioglu
authors.forename: Zeliha
authors.initials: Z
authors.lastname: Bodur
mesh_terms: D000052:Acanthosis Nigricans / Q000188:drug therapy; D017255:Acitretin / Q000008:administration & dosage*; D000279:Administration, Cutaneous; D000293:Adolescent; D001941:Breast Diseases / Q000188:drug therapy*; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage*; D007642:Keratosis / Q000188:drug therapy*; D009558:Nipples; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D007641:Keratolytic Agents; C055085:calcipotriene; D002117:Calcitriol; D017255:Acitretin