title: Pulseless electrical activity after rapid administration of fresh frozen plasma.
abstract: We present two extreme low birthweight preterm neonates who developed pulseless electrical activity during dilutional exchange transfusions with fresh frozen plasma (FFP). Both were polycythaemic recipient twins delivered prematurely because of foetal compromise as a result of twin-to-twin transfusion syndrome. The two events were associated with an acute fall in ionised calcium. We discuss the mechanism of these cardiac arrests and highlight the care required when infusing citrate containing blood products, particularly FFP, in order to avoid causing acute life-threatening hypocalcaemia.
authors.affiliation: Princess Anne Hospital, Southampton, England, UK. prhyde@doctors.org.uk
authors.forename: Philip
authors.initials: P
authors.lastname: Hyde
authors.forename: Victoria
authors.initials: V
authors.lastname: Puddy
mesh_terms: D001803:Blood Transfusion / Q000379:methods*; D019343:Citric Acid / Q000506:poisoning*; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced*; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D010949:Plasma / Q000502:physiology*; D065227:Transfusion Reaction; D014427:Twins
chemical_list: D019343:Citric Acid