title: Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study.
abstract: BACKGROUND
  The effect of weight loss on different plasma lipid subclasses at the molecular level is unknown. The aim of this study was to examine whether a diet-induced weight reduction result in changes in the extended plasma lipid profiles (lipidome) in subjects with features of metabolic syndrome in a 33-week intervention.
  
  
  RESULTS
  Plasma samples of 9 subjects in the weight reduction group and 10 subjects in the control group were analyzed using mass spectrometry based lipidomic and fatty acid analyses. Body weight decreased in the weight reduction group by 7.8+/-2.9% (p<0.01). Most of the serum triacylglycerols and phosphatidylcholines were reduced. The decrease in triacylglycerols affected predominantly the saturated short chain fatty acids. This decrease of saturated short chain fatty acid containing triacylglycerols correlated with the increase of insulin sensitivity. However, levels of several longer chain fatty acids, including arachidonic and docosahexanoic acid, were not affected by weight loss. Levels of other lipids known to be associated with obesity such as sphingolipids and lysophosphatidylcholines were not altered by weight reduction.
  
  
  CONCLUSIONS
  Diet-induced weight loss caused significant changes in global lipid profiles in subjects with abnormal glucose metabolism. The observed changes may affect insulin sensitivity and glucose metabolism in these subjects.
  
  
  BACKGROUND
  ClinicalTrials.gov NCT00621205.
authors.affiliation: School of Public Health and Clinical Nutrition, Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, Kuopio, Finland. ursula.schwab@uku.fi
authors.forename: Ursula
authors.initials: U
authors.lastname: Schwab
authors.forename: Tuulikki
authors.initials: T
authors.lastname: Seppänen-Laakso
authors.forename: Laxman
authors.initials: L
authors.lastname: Yetukuri
authors.forename: Jyrki
authors.initials: J
authors.lastname: Agren
authors.forename: Marjukka
authors.initials: M
authors.lastname: Kolehmainen
authors.forename: David E
authors.initials: DE
authors.lastname: Laaksonen
authors.forename: Anna-Liisa
authors.initials: AL
authors.lastname: Ruskeepää
authors.forename: Helena
authors.initials: H
authors.lastname: Gylling
authors.forename: Matti
authors.initials: M
authors.lastname: Uusitupa
authors.forename: Matej
authors.initials: M
authors.lastname: Oresic
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D004038:Diet, Reducing; D005227:Fatty Acids / Q000032:analysis / Q000097:blood*; D005260:Female; D044882:Glucose Metabolism Disorders / Q000097:blood / Q000178:diet therapy*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood* / Q000737:chemistry; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D005227:Fatty Acids; D014280:Triglycerides