Preparation of a solid dispersion by a dropping method to improve the rate of dissolution of meloxicam.
Application of a solid dispersion system is one of the methods used to increase the bioavailability of poorly water-soluble drugs. Adaptation of the dropping method from the chemical industry as a formulation procedure may help the scaling-up process and simplify the formulation of poorly water-soluble compounds. Meloxicam (ME), a nonsteroidal anti-inflammatory drug that is poorly soluble in water, and polyethylene glycol (PEG) 4000, a water-soluble carrier, were formulated by using a dropping method in an attempt to improve the dissolution of ME. Pure ME and physical mixtures and tablets of ME-PEG 4000 (1:3 ratio) were compared as regards their dissolution with samples formulated by the dropping method. The results revealed that the round particles (solid drops) exhibited a higher dissolution rate than those of the physical mixtures, tablets, and pure ME. Self-modeling curve resolution (SMCR) as a chemometric method was used to evaluate X-ray powder diffractometry (XRPD) data. The results demonstrated the presence of a new crystalline phase in the solid dispersion, which can help the fast and quantitative dissolution from the solid drops. The round particles can be adapted to individual therapy by using a distributor.
Bashiri-Shahroodi
Amir
A
Department of Pharmaceutical Technology, University of Szeged, Szeged, Hungary.
Nassab
Parya Reisi
PR
Szabó-Révész
Piroska
P
Rajkó
Róbert
R
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D004337:Drug Carriers / Q000737:chemistry*; D000077239:Meloxicam; D011092:Polyethylene Glycols / Q000737:chemistry*; D033362:Powder Diffraction / Q000379:methods; D012995:Solubility; D013607:Tablets; D013843:Thiazines / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D013607:Tablets; D013843:Thiazines; D013844:Thiazoles; D011092:Polyethylene Glycols; D000077239:Meloxicam