title: Lack of evidence for association of a UCH-L1 S18Y polymorphism with Parkinson's disease in a Han-Chinese population.
abstract: Mutation in UCH-L1 has been reported as a rare cause of autosomal dominant Parkinson's disease (PD). A S18Y polymorphism in the same gene has been associated with sporadic PD. We investigated the frequency of this polymorphism among the Han-Chinese ethnic population in a case-control study. A total of 600 patients with PD and 334 unrelated healthy controls were genotyped using PCR-restriction fragment length polymorphism analysis. We did not observe any difference in allele or genotype frequencies between the cases and the controls (P>0.05). Our results do not support a role for this variant in sporadic PD.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Chengdu, China.
authors.forename: Z-J
authors.initials: ZJ
authors.lastname: Zhang
authors.forename: J-M
authors.initials: JM
authors.lastname: Burgunder
authors.forename: X-K
authors.initials: XK
authors.lastname: An
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: W-J
authors.initials: WJ
authors.lastname: Chen
authors.forename: J-H
authors.initials: JH
authors.lastname: Zhang
authors.forename: Y-C
authors.initials: YC
authors.lastname: Wang
authors.forename: Y-M
authors.initials: YM
authors.lastname: Xu
authors.forename: Y-R
authors.initials: YR
authors.lastname: Gou
authors.forename: G-G
authors.initials: GG
authors.lastname: Yuan
authors.forename: X-Y
authors.initials: XY
authors.lastname: Mao
authors.forename: R
authors.initials: R
authors.lastname: Peng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D020133:Reverse Transcriptase Polymerase Chain Reaction; D043222:Ubiquitin Thiolesterase / Q000235:genetics*
chemical_list: C482860:UCHL1 protein, human; D043222:Ubiquitin Thiolesterase