title: Chemical constituents and antimicrobial activity of medicinal plants from Ghana: Cassia sieberiana, Haematostaphis barteri, Mitragyna inermis and Pseudocedrela kotschyi.
abstract: The antimicrobial activity of the sequential n-hexane, acetone and 50% aqueous methanol extracts of leaves, stem bark and roots of four species of medicinal plants, Cassia sieberiana DC. (Leguminosae), Haematostaphis barteri Hook. f. (Anacardiaceae), Mitragyna inermis (Willd.) O. Kuntze (Rubiaceae) and Pseudocedrela kotschyi (Schweinf.) Harms (Meliaceae), from Ghana were tested against Bacillus subtilis, Pseudomonas syringae and Cladosporium herbarum using TLC direct-autobiographic methods. Extracts from leaves, stem bark and roots of the four species gave a positive result against at least one test organism. Twelve of the 36 extracts were active against B. subtilis, four extracts were active against P. syringae and six were active against C. herbarum. Preliminary chemical analysis revealed the presence of flavonoids, stilbenes and alkaloids. This is the first report of a stilbene from the Anacardiaceae.
authors.affiliation: Department of Botany, University of Ghana, P.O. Box LG55 Legon-Accra, Ghana.
authors.forename: Alex
authors.initials: A
authors.lastname: Asase
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kokubun
authors.forename: Renée J
authors.initials: RJ
authors.lastname: Grayer
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Kite
authors.forename: Monique S J
authors.initials: MS
authors.lastname: Simmonds
authors.forename: Alfred A
authors.initials: AA
authors.lastname: Oteng-Yeboah
authors.forename: George T
authors.initials: GT
authors.lastname: Odamtten
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002366:Cassia / Q000737:chemistry; D002963:Cladosporium / Q000187:drug effects; D005869:Ghana; D016488:Medicine, African Traditional; D029582:Meliaceae / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D032065:Mitragyna / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D044224:Pseudomonas syringae / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts