title: Clear cell change in colonic polyps.
abstract: In this study, the pathogenesis of clear cell change in colorectal epithelial lesions was studied. A total of 4 cases of clear cell change (1 hyperplasic polyp and 3 adenomas) were characterized using histochemistry, immunohistochemistry, and electron microscopy. All lesions developed in the left colon. In all, 1 adenoma with clear cell dysplastic glands progressed to adenocarcinoma without clear cell change. Clear cell cytoplasmatic vacuoles were negative for glycogen and mucins (MUC 2, MUC 5AC). Ki-67 LI in clear cell adenoma components was lower than in common adenoma components of the same dysplasia grades (while p53 and beta-catenin were similarly expressed). Ultrastructural features of clear cell change showed features of lipid-like material. Clear cell change is found in hyperplastic and neoplastic lesions of the colon and is not due to the accumulation of glycogen or mucins. A degenerative nature of clear cell change is suggested by the demonstration of lipid-like material in the vacuoles of clear cells.
authors.affiliation: Department of Pathology, Hospital de S. João, Institute of Molecular Pathology and Immunology of the University of Porto, Portugal.
authors.forename: Catarina
authors.initials: C
authors.lastname: Eloy
authors.forename: José M
authors.initials: JM
authors.lastname: Lopes
authors.forename: Gil
authors.initials: G
authors.lastname: Faria
authors.forename: Herculano
authors.initials: H
authors.lastname: Moreira
authors.forename: Abílio
authors.initials: A
authors.lastname: Brandão
authors.forename: Teresa
authors.initials: T
authors.lastname: Silva
authors.forename: Fátima
authors.initials: F
authors.lastname: Carneiro
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000236:Adenoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002452:Cell Count; D002467:Cell Nucleus / Q000648:ultrastructure; D003106:Colon / Q000378:metabolism / Q000473:pathology*; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003593:Cytoplasm / Q000648:ultrastructure; D006801:Humans; D006965:Hyperplasia; D007124:Immunoenzyme Techniques; D066298:In Vitro Techniques; D007417:Intestinal Polyps / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen