Cutaneous dissemination of nasal NK/T-cell lymphoma in a young girl.
In Europe and the USA, the incidence of primary nasal natural killer (NK)/T-cell lymphoma is rare. The skin is one of the predilection sites for dissemination. Cutaneous dissemination is a poor prognostic sign and is consistently fatal. We describe the case of a 17-year-old white German girl with a primary nasal NK/T-cell lymphoma and cutaneous dissemination. She presented with multiple maculopapular patches involving the trunk and thighs, and a 4-week history of headache, fever and fatigue. Biopsies of the skin and the nasal mucosa were taken. Pathological examination of both specimens revealed a NK/T-cell lymphoma. Epstein-Barr virus RNA was detected in the lymphoma cells by in situ hybridization. Unfortunately, the patient died of disease within 1 week.
Sandner
A
A
Department of Otolaryngology, Head and Neck Surgery, Martin Luther University Halle-Wittenberg, Halle, Germany. annett.sandner@medizin.uni-halle.de
Helmbold
P
P
Winkler
M
M
Gattenlöhner
S
S
Müller-Hermelink
H-K
HK
Holzhausen
H-J
HJ
D000293:Adolescent; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000473:pathology*; D009669:Nose Neoplasms / Q000276:immunology / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*