title: High levels of substance P and CGRP in pseudosynovial fluid from patients with aseptic loosening of their hip prosthesis.
abstract: BACKGROUND
  Aseptic loosening is the most important complication after total hip arthroplasty (THA). The nervous system has been implicated in the etiology and pathogenesis of joint diseases.
  
  
  METHODS
  We compared levels of substance P (SP) and calcitonin gene-related peptide (CGRP) in pseudosynovial fluid from patients with aseptic loosening after THA with those in synovial fluid from patients undergoing primary THA for osteoarthritis, who served as controls. Levels of SP and CGRP were measured using an enzyme immunoassay.
  
  
  RESULTS
  We found that SP and CGRP levels were significantly higher in the pseudosynovial fluid of loose artificial joints than in the synovial fluid of controls.
  
  
  CONCLUSIONS
  SP and CGRP may have a role in aseptic loosening.
authors.affiliation: Department of Orthopedic Surgery, the Sixth People's Hospital, College of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Yebin
authors.initials: Y
authors.lastname: Qian
authors.forename: Bing-Fang
authors.initials: BF
authors.lastname: Zeng
authors.forename: Xian-Long
authors.initials: XL
authors.lastname: Zhang
authors.forename: Yao
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis* / Q000378:metabolism; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000378:metabolism / Q000601:surgery; D011475:Prosthesis Failure; D013373:Substance P / Q000032:analysis* / Q000378:metabolism; D013582:Synovial Fluid / Q000737:chemistry* / Q000378:metabolism
chemical_list: D013373:Substance P; D015740:Calcitonin Gene-Related Peptide