[Research progress on the action of praziquantel on voltage-gated Ca2+ channel in schistosomes].
Pharmacological actions of praziquantel against schistosome adult worms are thought to be directly linked to the disruption of Ca2+ homeostasis. The voltage-gated Ca2+ channel is an important factor in regulating the intracellular Ca2+ level. Studies have revealed that Ca2+ channel subunits may be the target for the action of praziquantel. This review summarizes the progress on the structure and function of the Ca2+ channel of Schistosoma spp and other Platyhelminths as well as the role of Ca2+ channel in action of praziquantel.
Zhang
Ling
L
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, MOH, China.
Zhou
Xiao-Nong
XN
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000502:physiology*; D020013:Calcium Signaling / Q000187:drug effects; D015801:Helminth Proteins / Q000502:physiology*; D011223:Praziquantel / Q000494:pharmacology*; D012547:Schistosoma / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology
D000871:Anthelmintics; D015220:Calcium Channels; D015801:Helminth Proteins; D011223:Praziquantel; D002118:Calcium