Novel DOTA-based prochelator for divalent peptide vectorization: synthesis of dimeric bombesin analogues for multimodality tumor imaging and therapy.
Dimeric peptidic vectors, obtained by the divalent grafting of bombesin analogues on a newly synthesized DOTA-based prochelator, showed improved qualities as tumor targeted imaging probes in comparison to their monomeric analogues.
Abiraj
Keelara
K
Division of Radiological Chemistry, Department of Radiology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Jaccard
Hugues
H
Kretzschmar
Martin
M
Helm
Lothar
L
Maecke
Helmut R
HR
D000970:Antineoplastic Agents / Q000138:chemical synthesis; D001839:Bombesin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000627:therapeutic use; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D019281:Dimerization; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D006801:Humans; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002614:Chelating Agents; D006573:Heterocyclic Compounds, 1-Ring; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D001839:Bombesin