title: Identification of a common gene expression response in different lung inflammatory diseases in rodents and macaques.
abstract: To identify gene expression responses common to multiple pulmonary diseases we collected microarray data for acute lung inflammation models from 12 studies and used these in a meta-analysis. The data used include exposures to air pollutants; bacterial, viral, and parasitic infections; and allergic asthma models. Hierarchical clustering revealed a cluster of 383 up-regulated genes with a common response. This cluster contained five subsets, each characterized by more specific functions such as inflammatory response, interferon-induced genes, immune signaling, or cell proliferation. Of these subsets, the inflammatory response was common to all models, interferon-induced responses were more pronounced in bacterial and viral models, and a cell division response was more prominent in parasitic and allergic models. A common cluster containing 157 moderately down-regulated genes was associated with the effects of tissue damage. Responses to influenza in macaques were weaker than in mice, reflecting differences in the degree of lung inflammation and/or virus replication. The existence of a common cluster shows that in vivo lung inflammation in response to various pathogens or exposures proceeds through shared molecular mechanisms.
authors.affiliation: Laboratory for Health Protection Research (GBO), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Jeroen.Pennings@rivm.nl
authors.forename: Jeroen L A
authors.initials: JL
authors.lastname: Pennings
authors.forename: Tjeerd G
authors.initials: TG
authors.lastname: Kimman
authors.forename: Riny
authors.initials: R
authors.lastname: Janssen
mesh_terms: D000818:Animals; D001249:Asthma / Q000235:genetics; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D008251:Macaca; D051379:Mice; D011014:Pneumonia / Q000235:genetics*; D051381:Rats