title: The role of exercise in amyotrophic lateral sclerosis.
abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting the motor nervous system. It causes progressive and cumulative physical disabilities in patients, and leads to eventual death due to respiratory muscle failure. The disease is diverse in its presentation, course, and progression. We do not yet fully understand the cause or causes of the disease, nor the mechanisms for its progression; thus, we lack effective means for treating this disease. Currently, we rely on a multidisciplinary approach to symptomatically manage and care for patients who have ALS. In this article, the authors review the literature on the role of exercise in patients who have ALS, and briefly compare what is known about exercise in other neuromuscular diseases.
authors.affiliation: Department of Neurology, Columbia University, 710 West 168th Street, 9th Floor, New York, NY 10032, USA. achen@neuro.columbia.edu
authors.forename: Amy
authors.initials: A
authors.lastname: Chen
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Montes
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mitsumoto
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000503:physiopathology* / Q000534:rehabilitation*; D004734:Energy Metabolism / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D011379:Prognosis