title: Burns: what are the pharmacological treatment options?
abstract: BACKGROUND
  Many advances have been made in the understanding and management of burn injury, dramatically increasing pharmacological decision options for burn care professionals. Since burn injury is so multi-faceted, these advances cross many injury processes, both acute and chronic.
  
  
  OBJECTIVE
  The purpose of this review was to highlight the advances and decision options across the entire scope of the burn injury process. The burn-related processes with the most significant pharmacological options of approved products are highlighted.
  
  
  METHODS
  The scope of the current research is the most pertinent literature, which has been summarized with the addition of a personal perspective.
  
  
  CONCLUSIONS
  Many advances over the past decade in multiple fields have made pharmacological options plentiful in burn care. That said, there are many problems for the burn patient which persist, making burn injury still the most severe form of trauma. These issues range from management of a catabolic state with involuntary weight loss in the critical burn to severe itching in the rehabilitating patient. There are also many more treatment options available today. Two key reasons stand out as the most prominent. One reason is the fact that burn care has become much more proactive, by searching out new approaches to solve old problems. Now the treatment approach is altering its focus on manipulating the course of a burn. Examples include the use of temporary skin substitutes in partial thickness or second degree burns, decreasing pain and increasing the healing rate. Another is the use of slow release silver dressing as the topical burn wound antimicrobial of choice, markedly reducing discomfort, the need for dressing changes and an overall decrease in infection. In larger, deeper burns, the approach has changed from the chronic management of an open burn wound to rapid excision and wound closure, eliminating the burn as a source of complications. In addition, there has been a very aggressive approach to controlling the profound hypermetabolic, catabolic response to burns, rather than simply treating the outcome of this predictable post-burn complication. Approaching psychosocial stress again by prevention rather than treatment of established problems is another example. The second reason for increased options and differences in management involves the mindset of those individuals taking care of burns. Tremendous differences in experience are involved in decision-making. Different opinions are based on the expertise and also the personal preferences of those managing the burn.
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, The Burn and Trauma Center, Boston, MA 02120, USA. Rhdemling@partners.org
authors.forename: Robert H
authors.initials: RH
authors.lastname: Demling
mesh_terms: D000208:Acute Disease; D002056:Burns / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D003657:Decision Making; D006801:Humans; D009779:Occlusive Dressings; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D018030:Silver Compounds / Q000627:therapeutic use; D013315:Stress, Psychological / Q000209:etiology / Q000517:prevention & control; D014945:Wound Healing
chemical_list: D018030:Silver Compounds