Acute hepatitis associated with treatment of Peyronie's disease with potassium para-aminobenzoate (Potaba).
BACKGROUND
Potassium para-aminobenzoate is an agent used in the treatment of sclerotic diseases including Peyronie's disease of the penis. It has been reported that this medication may have been responsible for cases of acute liver injury.


OBJECTIVE
To inform clinicians of the possibility of an adverse drug event associated with the oral intake of potassium para-aminobenzoate by reporting an additional case and compiling information from previous reports.


METHODS
The affected patient's medical records were diligently reviewed; all available and relevant information pertaining to this adverse event is reported. Similar case reports were analyzed and compared, and relevant information was compiled in this report.


RESULTS
The patient enjoyed a full biochemical recovery from his hepatitis 4 months after discontinuation of potassium para-aminobenzoate.


CONCLUSIONS
To date, the oral use of potassium para-aminobenzoate has been reported to be linked to acute liver injury in six individuals. Appropriate management of this adverse drug event is the immediate discontinuation of the offending drug and general patient support measures.
Roy
Joey
J
McGill University, Montreal, Canada. joey.roy@mail.mcgill.ca
Carrier
Serge
S
D010129:4-Aminobenzoic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D000284:Administration, Oral; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D010411:Penile Induration / Q000188:drug therapy*; D016896:Treatment Outcome
D010129:4-Aminobenzoic Acid