title: [A long-surviving patient with lung pleomorphic carcinoma treated with postoperative carboplatin and paclitaxel combination chemotherapy].
abstract: We presented the case of a 46-year-old man with no medical or family history but with a history of smoking 3 packs of cigarettes per day for the past 25 years. He was admitted to our hospital due to hemoptysis. Chest computed tomography revealed a tumor of right upper lung and interstitial pneumonia in the surrounding lung parenchyma. He was operated upon and diagnosed with stage IIB pleomorphic carcinoma of the lung with invasion of the chest wall. He underwent three courses of postoperative carboplatin (CBDCA) (area under the curve 5 on day 1, every 3 weeks and paclitaxel(PTX) (200 mg/m(2); day 1, every 3 weeks) combination chemotherapy. No recurrence was observed for a period of 760 days after the operation. According to previous reports, lung pleomorphic carcinoma is aggressive and has a poor prognosis. Further, the significance of chemotherapy in the management of this disease has not been established. Postoperative combination chemotherapy of CBDCA and PTX may result in a good prognosis for this disease.
authors.affiliation: Dept. of Internal Medicine, Health Insurance Naruto Hospital.
authors.forename: Shingen
authors.initials: S
authors.lastname: Nakamura
authors.forename: Noriaki
authors.initials: N
authors.lastname: Horiuchi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Katsura
authors.forename: Kana
authors.initials: K
authors.lastname: Shichijo
authors.forename: Sumiko
authors.initials: S
authors.lastname: Yoshida
authors.forename: Eiji
authors.initials: E
authors.lastname: Harada
authors.forename: Takaya
authors.initials: T
authors.lastname: Matsushita
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Oshima
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Matsuzaki
authors.forename: Yasutami
authors.initials: Y
authors.lastname: Tamaki
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Kimura
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Takeichi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujimoto
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Masuda
authors.forename: Naohito
authors.initials: N
authors.lastname: Iwasaka
authors.forename: Sadao
authors.initials: S
authors.lastname: Shinomiya
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000145:classification / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000627:therapeutic use*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D016190:Carboplatin; D017239:Paclitaxel