title: Antifungal activity of valinomycin, a peptide antibiotic produced by Streptomyces sp. Strain M10 antagonistic to Botrytis cinerea.
abstract: A strain of Streptomyces sp. (M10) antagonistic to Botrytis cinerea was isolated from orchard soil obtained from Jeju Island, Korea. An antifungal substance (CN1) was purified from the culture extracts of the strain, and then identified as valinomycin through extensive spectroscopic analyses. Valinomycin showed potent in vitro antifungal activity against Botrytis cinerea and also in vivo control efficacy against Botrytis blight development in cucumber plants. Overall, the disease control efficacy of valinomycin was similar to that of vinclozolin, a commercial fungicide. This study provides the first report on the disease control efficacy of valinomycin against Botrytis blight.
authors.affiliation: Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Korea.
authors.forename: Cheol Nam
authors.initials: CN
authors.lastname: Park
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.forename: Beom Seok
authors.initials: BS
authors.lastname: Kim
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020171:Botrytis / Q000187:drug effects*; D018553:Cucumis sativus / Q000382:microbiology; D005658:Fungi / Q000187:drug effects; D005659:Fungicides, Industrial / Q000494:pharmacology; D007723:Korea; D010080:Oxazoles / Q000494:pharmacology; D010802:Phylogeny; D010935:Plant Diseases / Q000382:microbiology; D012988:Soil Microbiology; D013302:Streptomyces / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000378:metabolism*; D014634:Valinomycin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D005659:Fungicides, Industrial; D010080:Oxazoles; D014634:Valinomycin; C025643:vinclozolin