Induced hypothermia in acute ischemic stroke.
BACKGROUND
Induced hypothermia is a promising neuroprotective treatment for acute ischemic stroke. Data from both global and focal ischemia animal models have been encouraging. However, only a few small clinical studies have investigated its use in humans.


OBJECTIVE
To review the background, possible mechanisms of action, and the preclinical and clinical data supporting the neuroprotective role of induced hypothermia following acute ischemic stroke.


METHODS
A literature search was performed using the PubMed database. Only papers in English were reviewed.


CONCLUSIONS
Induced hypothermia is effective as a neuroprotectant in animal models of acute ischemic stroke. Its multimodal mechanism of action makes it a very attractive method of neuroprotection. Although human studies suggest it is safe and feasible, larger randomized controlled trials are necessary to address clinical efficacy and to refine the methods and parameters of induced hypothermia protocols.
Lazzaro
Marc A
MA
Rush University Medical Center, Department of Neurological Sciences, 1725 W. Harrison Street, Suite 1121, Chicago, IL 60612, USA. mlazzaro2@gmail.com
Prabhakaran
Shyam
S
D000208:Acute Disease; D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D002545:Brain Ischemia / Q000150:complications* / Q000378:metabolism; D002986:Clinical Trials as Topic; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D020521:Stroke / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D016896:Treatment Outcome