title: A dog with acute myelomonocytic leukemia.
abstract: A three-year-old dog with marked leukocytosis, lymphadenopathy, and diarrhea showed an increase in unidentified blasts in the peripheral blood, and they were proliferated in the bone marrow. The dog was diagnosed with myelomonocytic leukemia (M4) because the blast cells were demonstrated by cytochemical staining to be both myeloid and monocytic cells. Although the dog was treated with a multi-combination chemotherapy and induction therapy using vitamin K2, it died on day 47 after the first admission. This case is the first report of M4 in Japan.
authors.affiliation: Laboratory of Veterinary Internal Medicine II, Azabu University, Kanagawa, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Hisasue
authors.forename: Tomomi
authors.initials: T
authors.lastname: Nishimura
authors.forename: Sakurako
authors.initials: S
authors.lastname: Neo
authors.forename: Naho
authors.initials: N
authors.lastname: Nagashima
authors.forename: Takefumi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Ryo
authors.initials: R
authors.lastname: Tsuchiya
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Yamada
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003561:Cytarabine / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology*; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D006403:Hematologic Tests; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011239:Prednisolone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use; D014812:Vitamin K / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D003561:Cytarabine; D014812:Vitamin K; D014750:Vincristine; D004317:Doxorubicin; D011239:Prednisolone