title: Contemporary analysis of the influence of acute kidney injury after reduced intensity conditioning haematopoietic cell transplantation on long-term survival.
abstract: We evaluated retrospectively the incidence of acute kidney injury (AKI), defined by risk, injury, failure, loss and end-stage kidney disease (RIFLE) and its influence on long-term survival, in 82 patients aged 18-60 years who underwent a reduced intensity conditioning (RIC) haematopoietic cell transplantation (HCT). Patients (53.6%) developed AKI after HCT: 25% were on risk, 45.5% on injury and 29.5% on failure. In all, 64 patients survived after 100 days of post transplant and were available for long-term survival analysis. At follow-up, 43.7% of patients died. A 5-year overall survival of AKI patients was 41.6% as compared with 67.1% for those who did not develop AKI (P=0.028), and decreased according to AKI severity (risk, 55.6%; injury plus failure, 33.3%; P=0.045). After adjusting for age, history of cardiovascular disease, high-risk disease and chronic GVHD, AKI predicted 5-year overall mortality (AKI: adjusted hazards ratio (AHR), 2.36, 95% CI: 1.03-5.37; P=0.041). Moreover, moderate and severe AKI (injury plus failure) was also associated with an increased 5-year overall mortality (injury plus failure: AHR, 1.64, 95% CI: 1.06-2.54; P=0.024). According to RIFLE, 53.6% of patients had AKI after RIC HCT. Such patients have poor long-term survival, particularly in moderate or severe AKI.
authors.affiliation: Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Lisboa, Portugal. jalopes93@hotmail.com
authors.forename: J A
authors.initials: JA
authors.lastname: Lopes
authors.forename: S
authors.initials: S
authors.lastname: Gonçalves
authors.forename: S
authors.initials: S
authors.lastname: Jorge
authors.forename: M
authors.initials: M
authors.lastname: Raimundo
authors.forename: L
authors.initials: L
authors.lastname: Resende
authors.forename: F
authors.initials: F
authors.lastname: Lourenço
authors.forename: J F
authors.initials: JF
authors.lastname: Lacerda
authors.forename: C
authors.initials: C
authors.lastname: Martins
authors.forename: J A
authors.initials: JA
authors.lastname: do Carmo
authors.forename: J M F
authors.initials: JM
authors.lastname: Lacerda
authors.forename: M M
authors.initials: MM
authors.lastname: Prata
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D019172:Transplantation Conditioning / Q000379:methods; D055815:Young Adult