title: Angiogenesis as a target in neuroblastoma.
abstract: Several research investigations on neuroblastoma (NB) have shown the important dependency of this embryonic tumour on angiogenesis, especially in the advanced and aggressive stages. However, the first pre-clinical data on anti-angiogenic drugs in NB have not been published until recently and clinical trials with anti-angiogenic agents in NB treatment protocols are still missing. Here, we summarise current knowledge on the important role and mechanisms of angiogenesis in NB, and report available pre-clinical results of anti-angiogenic agents used to treat NB. This review clearly shows that angiogenesis is a target in NB and that clinical trials are urgently needed to bring forward promising anti-angiogenesis treatment strategies into NB therapy.
authors.affiliation: Pharmacology and New Treatments in Cancer, Institut Gustave Roussy, University of Paris-Sud, UPRES EA3535, Villejuif, France. jochen.roessler@uniklinik-freiburg.de
authors.forename: Jochen
authors.initials: J
authors.lastname: Rössler
authors.forename: Melissa
authors.initials: M
authors.lastname: Taylor
authors.forename: Birgit
authors.initials: B
authors.lastname: Geoerger
authors.forename: Francoise
authors.initials: F
authors.lastname: Farace
authors.forename: Jeanette
authors.initials: J
authors.lastname: Lagodny
authors.forename: Regine
authors.initials: R
authors.lastname: Peschka-Süss
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Niemeyer
authors.forename: Gilles
authors.initials: G
authors.lastname: Vassal
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D008833:Microcirculation; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics; D009447:Neuroblastoma / Q000098:blood supply / Q000188:drug therapy* / Q000235:genetics; D009857:Oncogenes / Q000235:genetics; D012583:Schwann Cells / Q000378:metabolism
chemical_list: D020533:Angiogenesis Inhibitors