title: Magnetic resonance cholangiopancreatography: potential usefulness of dehydrocholic acid (DHCA) administration in the evaluation of biliary disease.
abstract: OBJECTIVE
  The aim of this study was to investigate whether exogenous dehydrocholic acid (DHCA) was useful to enhance the delineation of the biliary tree.
  
  
  METHODS
  Our study population comprised 14 patients. Magnetic resonance cholangiopancreatography was acquired before and after the administration of DHCA. Two different MRCP snap shot techniques were applied: thick-slab two-dimensional (2D) (coronal) single shot turbo spin echo T2-weighted sequences and multisection thin-slab, 2D (coronal) single shot turbo spin echo T2-weighted sequences with three-dimensional (3D) maximum intensity projection (MIP) post processing. Volume rendering was prepared based on the source images, and the pixel size was visually adjusted to the biliary area of MRCP to measure the biliary tree volume.
  
  
  RESULTS
  DHCA increased the bile duct volume in 13 of the 14 patients. It provided a better visualization of the biliary tree in 11 patients. The three patients without improvement in visualization included 1 patient with liver cirrhosis secondary to portoenterostomy for congenital biliary dilatation and 2 patients with cholecystectomy who had the bile ducts filled with bile by the time of the administration.
  
  
  CONCLUSIONS
  It was suggested that administration of DHCA could enhance the delineation of the biliary tree on MRCP images.
authors.affiliation: Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sakai
authors.forename: Toshio
authors.initials: T
authors.lastname: Tsuyuguchi
authors.forename: Seigo
authors.initials: S
authors.lastname: Yukisawa
authors.forename: Shin
authors.initials: S
authors.lastname: Tsuchiya
authors.forename: Harutoshi
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Kaoru
authors.initials: K
authors.lastname: Miyakawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ebara
authors.forename: Hiroi
authors.initials: H
authors.lastname: Nonaka
authors.forename: Hiroo
authors.initials: H
authors.lastname: Ikehira
authors.forename: Takayuki
authors.initials: T
authors.lastname: Obata
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokosuka
authors.forename: Masaru
authors.initials: M
authors.lastname: Miyazaki
mesh_terms: D000328:Adult; D000368:Aged; D001649:Bile Duct Diseases / Q000175:diagnosis*; D002756:Cholagogues and Choleretics; D049448:Cholangiopancreatography, Magnetic Resonance; D003685:Dehydrocholic Acid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002756:Cholagogues and Choleretics; D003685:Dehydrocholic Acid