The protective effect of fish n-3 fatty acids on cerebral ischemia in rat prefrontal cortex.
This study presents neuroprotective effects of fish n-3 EFA on the prefrontal cortex after cerebral ischemia and reperfusion. Eighteen rats divided into three groups. Group A rats were used as control. Cerebral ischemia and reperfusion was produced in rats either on a standard diet (Group B) or a standard diet plus fish n-3 EFA for 14 days (Group C). The malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD) and catalase (CAT) were measured and the number of apoptotic neurons was counted. The levels of MDA and activities of SOD increased in Group B rats as compared to Group A rats, and decreased in Group C rats as compared to Group B rats. The activities of CAT increased in Group C as compared to Group B rats. The number of apoptotic neurons in the prefrontal cortex was lower in Group C as compared to Group B rats.
Ozen
Oguz Aslan
OA
Kocatepe University, School of Medicine, Department of Anatomy, Afyonkarahisar, Turkey.
Cosar
Murat
M
Sahin
Onder
O
Fidan
Huseyin
H
Eser
Olcay
O
Mollaoglu
Hakan
H
Alkoc
Ozan
O
Yaman
Mehmet
M
Songur
Ahmet
A
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D002374:Catalase / Q000032:analysis / Q000378:metabolism; D002452:Cell Count; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D004041:Dietary Fats / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D015525:Fatty Acids, Omega-3 / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D005396:Fish Products; D005526:Food, Formulated; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000378:metabolism; D009410:Nerve Degeneration / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control; D013482:Superoxide Dismutase / Q000032:analysis / Q000378:metabolism; D016896:Treatment Outcome
D015415:Biomarkers; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D018696:Neuroprotective Agents; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase