Antimalarial activity of a new stilbene glycoside from Parthenocissus tricuspidata in mice.
A novel stilbene glycoside [piceid-(1-->6)-beta-d-glucopyranoside; PBG] from Parthenocissus tricuspidata was tested in vivo against Plasmodium berghei. PBG exhibited significant blood schizontocidal activity in a 4-day early infection, a repository evaluation, and an established infection, with a significant mean survival time comparable to that obtained with the standard drug, chloroquine (5 mg x kg(-1) x day(-1)).
Park
Won-Hwan
WH
Department of Diagnostics and Cardiovascular Medical Research Center, College of Korean Medicine, Dongguk University, Gyeong-Ju, South Korea.
Lee
Sung-Jae
SJ
Moon
Hyung-In
HI
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000627:therapeutic use; D002738:Chloroquine / Q000627:therapeutic use; D006027:Glycosides / Q000737:chemistry / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010962:Plasmodium berghei / Q000187:drug effects*; D013267:Stilbenes / Q000737:chemistry / Q000627:therapeutic use; D016896:Treatment Outcome; D027844:Vitaceae / Q000737:chemistry*
D000962:Antimalarials; D006027:Glycosides; D010936:Plant Extracts; D013267:Stilbenes; D002738:Chloroquine