title: Intratympanic gentamicin therapy for control of vertigo in unilateral Menire's disease: a prospective, double-blind, randomized, placebo-controlled trial.
abstract: CONCLUSIONS
  Intratympanic application of gentamicin is a relatively safe and efficient treatment for the reduction of complaints of vertigo attacks associated with Menière's disease. The treatment also reduces the severity of the perceived aural fullness.
  
  
  OBJECTIVE
  To investigate the effectiveness of intratympanic gentamicin treatment in patients with unilateral Menière's disease.
  
  
  METHODS
  In a prospective, double-blind, randomized, placebo-controlled clinical trial subjects scored vertigo complaints, aural fullness and tinnitus, before, during and up to 1 year after treatment. Hearing loss was monitored with pure tone audiometry.
  
  
  RESULTS
  Gentamicin treatment resulted in a significant reduction of the score for vertigo complaints and the score for perceived aural fullness. A small increase in hearing loss (average 8 dB) was measured in the gentamicin group.
authors.affiliation: Department of Otorhinolaryngology, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Rolf J
authors.initials: RJ
authors.lastname: Postema
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Kingma
authors.forename: Hero P
authors.initials: HP
authors.lastname: Wit
authors.forename: Frans W J
authors.initials: FW
authors.lastname: Albers
authors.forename: Bernard F A M
authors.initials: BF
authors.lastname: Van Der Laan
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004432:Ear, Middle; D005260:Female; D005500:Follow-Up Studies; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications*; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D014717:Vertigo / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins