Comparative study of the in vitro activity of lomefloxacin versus lomefloxacin combined with metronidazole versus lomefloxacin in combination with amoxicillin/clavulanic acid against Chlamydia trachomatis.
The role of Chlamydia trachomatis in both acute and chronic salpingitis is well known but other bacterial species can act symbiotically with this organism to enhance pathogenicity. The advent of the fluoroquinolones-with their very broad spectrum of activity particularly on chlamydial species, gonococci and the Enterobacteriaceae-hase raised the possibility that new antibiotic combinations may be used in the treatment of salpingitis. Since Chlamydia trachomatis is an intracellular pathogen, we devised a cell culture system to evaluate the efficacy (or any antagonistic effects) of lomefloxacin in combination with metronidazole and lomefloxacin in combination with amoxicillin/clavulanic acid. Our study showed that there appeared to be no inoculum effect. In addition, we found no in vitro antagonism between lomefloxacin and metronidazole or lomefloxacin and amoxicillin/clavullanic acid against Chlamydia trachomatis. These results justify the use of these combinations in vivo in patients infected with Chlamydia trachomatis infections.
Orfila
J
J
Centre Hospitalo-Universitaire, Amiens, France.
Haider
F
F