title: Modeling of nonphase mechanisms in ultrasonic modulation of light propagation.
abstract: While phase variation due to ultrasonic modulation of coherent light has been extensively studied in acousto-optical imaging, fewer groups have studied nonphase mechanisms of ultrasonic modulation, which may be important in exploring ultrasonic modulation of incoherent light for imaging. We have developed a versatile Monte Carlo based method that can model not only phase variation due to refractive index changes and scatterer displacement in tissue or tissue-like phantoms, but also amplitude and exit location variations due to the changes in optical properties and refractive index under ultrasonic modulation, in which the exit location variation has not, to the best of our knowledge, been modeled previously. Our results show that the modulation depth due to the exit location variation is three orders of magnitude higher than that due to amplitude variation, but two to three orders of magnitude lower than that due to phase variation for monochromatic light. Furthermore it is found that the modulation depth in reflectance due to the exit location variation is larger than that in transmittance for small source-detector separations.
authors.affiliation: Department of Biomedical Engineering, Duke University, Room 136, Hudson Hall, Box 90281, Durham, North Carolina 27708-0281, USA.
authors.forename: Quan
authors.initials: Q
authors.lastname: Liu
authors.forename: Stephen
authors.initials: S
authors.lastname: Norton
authors.forename: Tuan
authors.initials: T
authors.lastname: Vo-Dinh
mesh_terms: D003198:Computer Simulation; D054459:Elasticity Imaging Techniques / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008027:Light; D008962:Models, Theoretical; D012542:Scattering, Radiation; D014463:Ultrasonography / Q000379:methods*