Effect of corosolic acid on the hydrolysis of disaccharides.
The banaba leaf (Lagerstroemia speciosa L.) has been used in traditional Oriental medicine to treat diabetes in the Philippines. It contains corosolic acid (CA), a compound which has a hypoglycemic effect. We examined the effect of CA on blood glucose levels and the hydrolysis of disaccharides in the small intestine in mice. CA (10 mg/kg body weight) improved hyperglycemia after an oral administration of sucrose, and significantly reduced the hydrolysis of sucrose in the small intestine. These results suggest that the hypoglycemic activity of CA is derived, at least in part, due to the inhibition of the hydrolysis of sucrose.
Takagi
Satoshi
S
Department of Clinical Nutrition, Suzuka University of Medical Science, Suzuka, Mie, Japan.
Miura
Toshihiro
T
Ishibashi
Chinami
C
Kawata
Takanori
T
Ishihara
Eriko
E
Gu
Yeunhwa
Y
Ishida
Torao
T
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000378:metabolism*; D004187:Disaccharides / Q000378:metabolism*; D004195:Disease Models, Animal; D006868:Hydrolysis / Q000187:drug effects; D006943:Hyperglycemia / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D007785:Lactose / Q000378:metabolism; D031563:Lagerstroemia; D008297:Male; D008320:Maltose / Q000378:metabolism; D008518:Medicine, East Asian Traditional; D051379:Mice; D008820:Mice, Obese; D008517:Phytotherapy / Q000379:methods*; D013395:Sucrose / Q000378:metabolism*; D013997:Time Factors; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology*
D001786:Blood Glucose; D004187:Disaccharides; D007004:Hypoglycemic Agents; D014315:Triterpenes; D013395:Sucrose; D008320:Maltose; C113861:corosolic acid; D007785:Lactose