The tert-butyl group in chemistry and biology.
The unique reactivity pattern elicited by the crowded tert-butyl group is highlighted by summarising characteristic applications. Starting from the use of this simple hydrocarbon moiety in chemical transformations, via its relevance in Nature and its implication in biosynthetic and biodegradation pathways, the way through to its possible application in biocatalytic processes is described.
Bisel
Philippe
P
Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.
Al-Momani
Loay
L
Müller
Michael
M
D001685:Biological Factors / Q000737:chemistry; D002384:Catalysis; D007930:Leucine / Q000031:analogs & derivatives; D008968:Molecular Conformation; D015394:Molecular Structure; D009930:Organic Chemicals / Q000737:chemistry*; D010084:Oxidation-Reduction; D014633:Valine / Q000031:analogs & derivatives / Q000737:chemistry; D020002:tert-Butyl Alcohol / Q000737:chemistry*
D001685:Biological Factors; D009930:Organic Chemicals; C089871:2-amino-3,3-dimethylbutanoic acid; D007930:Leucine; D014633:Valine; D020002:tert-Butyl Alcohol