Slower onset of vasodilating action of brain natriuretic peptide (BNP) compared to atrial natriuretic peptide (ANP) in human forearm resistant vessels.
OBJECTIVE
To investigate possible differences in the time course of vasodilating effects of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in humans.


METHODS
We measured forearm blood flow (FBF) by strain gauge plethymography and cyclic GMP spillover during and after intra-arterial infusions of BNP and ANP at 16.2 pmol/min for 30 min in healthy subjects.


RESULTS
The steady-state responses of FBF and cyclic GMP to the infusion were achieved approximately 20 min after commencement of the infusion of BNP, but within 5 min for ANP, with similar magnitudes of maximum responses. These parameters more slowly returned to the baseline value after withdrawal of the BNP infusion than after the ANP infusion.


CONCLUSIONS
The onset and disappearance of the guanylate cyclase-stimulating and vasodilating effects of BNP were significantly slower than those of ANP. This differing mode of vasodilator action may be relevant to the therapeutic use of natriuretic peptides.
Minami
Hironobu
H
Department of Clinical Pharmacology & Therapeutics, University of the Ryukyus, Graduate School of Medicine, Nishihara, Okinawa, Japan.
Yasu
Takanori
T
Tagawa
Tatsuya
T
Yamakawa
Ken
K
Ueda
Shinichiro
S
D000293:Adolescent; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000494:pharmacology*; D006152:Cyclic GMP / Q000097:blood*; D005542:Forearm / Q000098:blood supply; D006162:Guanylate Cyclase / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*; D055815:Young Adult
D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor; D006162:Guanylate Cyclase; D006152:Cyclic GMP