Quinic acid derivatives from Saussurea triangulata attenuates glutamate-induced neurotoxicity in primary cultured rat cortical cells.
The leaves of Saussurea triangulata (Compositae) have been eaten with rice as a wrapping vegetable for preventing neuro-aging. However, the components responsible for the neuroprotective effects of S. triangulata still remain unidentified. In the process of investigating the neuroprotective activity of S. triangulata, we found that a methanol extract of S. triangulata exhibited significant protection against glutamate-induced toxicity in primary cultured rat cortical cells. Three quinic acid derivatives were isolated from the n-BuOH fraction of S. triangulata. Among these three quinic acid derivatives, methyl 5-caffeoylquinic acid (3) exhibited significant neuroprotective activities against glutamate-induced toxicity exhibiting cell viability of about 50%, at concentrations ranging from 0.1 microM to 10 microM. Therefore, the neuroprotective effect of S. triangulata might be due to the inhibition of glutamate-induced toxicity by the quinic acid derivatives from S. triangulata.
Chung
Ill-Min
IM
Department of Applied Life science, Kon Kuk University, Seoul.
Kim
Min-Young
MY
Park
Won-Hwan
WH
Moon
Hyung-In
HI
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000473:pathology*; D018698:Glutamic Acid / Q000009:adverse effects; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology; D020258:Neurotoxicity Syndromes / Q000188:drug therapy*; D011801:Quinic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D030441:Saussurea / Q000737:chemistry*
D018696:Neuroprotective Agents; D011801:Quinic Acid; D018698:Glutamic Acid