[Study of the Drosophila melanogaster trf2 gene and its protein product].
The Drosophila melanogaster TRF2 protein regulates transcription of several genes. The trf2 gene structure was studied. The gene proved to code for two protein isoforms, a known 75-kDa isoform and a newly identified 175-kDa isoform. The new isoform combines the known isoform sequence with an extended N end containing a coiled-coil motif. The long TRF2 isoform was found to act as a component of a multiprotein complex, including ISWI ATPase as well.
Kopytova
D V
DV
nikolenko
Iu V
IuV
Lebedeva
L A
LA
Nabirochkina
E N
EN
Shidlovskiĭ
Iu V
IuV
Georgieva
S G
SG
Krasnov
A N
AN
D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism*; D020816:Amino Acid Motifs / Q000502:physiology; D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster; D017344:Genes, Insect / Q000502:physiology*; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D035341:Telomeric Repeat Binding Protein 2 / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology*
D029721:Drosophila Proteins; C086468:ISWI protein; D046912:Multiprotein Complexes; D020033:Protein Isoforms; C509085:TRF2 protein, Drosophila; D035341:Telomeric Repeat Binding Protein 2; D014157:Transcription Factors; D000251:Adenosine Triphosphatases