title: Effect of atorvastatin on hs-CRP in acute coronary syndrome.
abstract: OBJECTIVE
  To evaluate the effect of a lower dose (20 mg) of atorvastatin on hs-CRP concentrations in patients with ACS.
  
  
  METHODS
  Group A (n = 50) patients received atorvastatin 20 mg day(-1) for 4 weeks in addition to standard anti-anginal treatment. Group B (n = 50) patients received standard anti-anginal treatment without atorvastatin.
  
  
  RESULTS
  hs-CRP concentrations decreased in both groups, but the decrease was greater in group A. The decrease in hs-CRP was also significantly greater in the subgroups of smoking, hypertension and past history of cardiovascular disease with atorvastatin.
  
  
  CONCLUSIONS
  The use of a lower dose (20 mg) of atorvastatin can offer an attractive approach for early treatment of patients with ACS.
authors.affiliation: Department of Pharmacology, Christian Medical College and Hospital, Ludhiana-141 008, India.
authors.forename: Ankur
authors.initials: A
authors.lastname: Gupta
authors.forename: Dinesh K
authors.initials: DK
authors.lastname: Badyal
authors.forename: Prem P
authors.initials: PP
authors.lastname: Khosla
authors.forename: Bharti
authors.initials: B
authors.lastname: Uppal
authors.forename: Thannikot M
authors.initials: TM
authors.lastname: Jaison
authors.forename: Sandeep
authors.initials: S
authors.lastname: Chopra
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy*; D000328:Adult; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D000069059:Atorvastatin; D002097:C-Reactive Protein / Q000187:drug effects* / Q000378:metabolism; D008078:Cholesterol, LDL / Q000187:drug effects* / Q000378:metabolism; D003327:Coronary Disease / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006538:Heptanoic Acids / Q000008:administration & dosage*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011758:Pyrroles / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D006538:Heptanoic Acids; D008055:Lipids; D011758:Pyrroles; D002097:C-Reactive Protein; D000069059:Atorvastatin