Effect of synaptic connectivity on long-range synchronization of fast cortical oscillations.
Cortical gamma oscillations in the 20- to 80-Hz range are associated with attentiveness and sensory perception and have strong connections to both cognitive processing and temporal binding of sensory stimuli. These gamma oscillations become synchronized within a few milliseconds over distances spanning a few millimeters in spite of synaptic delays. In this study using in vivo recordings and large-scale cortical network models, we reveal a critical role played by the network geometry in achieving precise long-range synchronization in the gamma frequency band. Our results indicate that the presence of many independent synaptic pathways in a two-dimensional network facilitate precise phase synchronization of fast gamma band oscillations with nearly zero phase delays between remote network sites. These findings predict a common mechanism of precise oscillatory synchronization in neuronal networks.
Bazhenov
M
M
Department of Cell Biology and Neuroscience, University of California, Riverside, Riverside, CA 92521, USA. Maksim.Bazhenov@ucr.edu
Rulkov
N F
NF
Timofeev
I
I
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D003344:Cortical Synchronization; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology; D016571:Neural Networks, Computer; D017966:Pyramidal Cells / Q000502:physiology; D013569:Synapses / Q000502:physiology*