title: Chemical preparation of sialyl Lewis x using an enzymatically synthesized sialoside building block.
abstract: The sialyl Lewis x tetrasaccharide with a propylamine aglycon was assembled by chemoselective glycosylation from a p-tolyl thioglycosyl donor obtained from an enzymatically synthesized sialodisaccharide. Combining the advantages of highly efficient enzymatic synthesis of sialoside building blocks, and diverse chemical glycosylation, this chemoenzymatic approach is practical for obtaining complex sialosides and their analogues.
authors.affiliation: Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA.
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Cao
authors.forename: Shengshu
authors.initials: S
authors.lastname: Huang
authors.forename: Jiansong
authors.initials: J
authors.lastname: Cheng
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Li
authors.forename: Saddam
authors.initials: S
authors.lastname: Muthana
authors.forename: Bryan
authors.initials: B
authors.lastname: Son
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
mesh_terms: D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008958:Models, Molecular; D008968:Molecular Conformation; D009362:Neoplasm Metastasis / Q000503:physiopathology; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D019087:Selectins / Q000502:physiology; D012794:Sialic Acids / Q000737:chemistry; D000080506:Sialyl Lewis X Antigen
chemical_list: D009844:Oligosaccharides; D019087:Selectins; D012794:Sialic Acids; D000080506:Sialyl Lewis X Antigen