title: [Improvement of synthesis of quercetin and genistein sulfates and identification by HPLC-MS].
abstract: OBJECTIVE
  To improve synthesis of quercetin and genistein sulfates.
  
  
  METHODS
  Quercetin and genistein were esterified with concentrated sulfuric acid for 3 hours in ice and esterfication was terminated by neutralization with 6N NaOH. Derivatives were identified by HPLC-APCI-MS.
  
  
  RESULTS
  Quercetin and genistein derivatives were only one compound of monosulfate.
  
  
  CONCLUSIONS
  The improvement of synthesis of quercetin and genistein sulfates is a convenient method for obtaining soluble derivatives of the flavonoids.
authors.affiliation: Guangdong Medical College, Institute of Biochemistry and Molecular Biology, Zhanjiang 524023, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Deng
authors.forename: Nian-Ci
authors.initials: NC
authors.lastname: Liang
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004951:Esterification; D019833:Genistein / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods*; D011794:Quercetin / Q000737:chemistry*; D013463:Sulfuric Acid Esters / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D014867:Water / Q000737:chemistry
chemical_list: D013463:Sulfuric Acid Esters; D014867:Water; D011794:Quercetin; D019833:Genistein