title: The effect of pheochromocytoma treatment on subclinical inflammation and endocrine function of adipose tissue.
abstract: The aim of our study was to evaluate the influence of surgical removal of pheochromocytoma on the endocrine function of adipose tissue and subclinical inflammation as measured by circulating C-reactive protein (CRP) levels. Eighteen patients with newly diagnosed pheochromocytoma were included into study. Anthropometric measures, biochemical parameters, serum CRP, leptin, adiponectin and resistin levels were measured at the time of diagnosis and six months after surgical removal of pheochromocytoma. Surgical removal of pheochromocytoma significantly increased body weight, decreased both systolic and diastolic blood pressure, fasting blood glucose and glycated hemoglobin levels. Serum CRP levels were decreased by 50 % six months after surgical removal of pheochromocytoma (0.49+/-0.12 vs. 0.23+/-0.05 mg/l, p<0.05) despite a significant increase in body weight. Serum leptin, adiponectin and resistin levels were not affected by the surgery. We conclude that increased body weight in patients after surgical removal of pheochromocytoma is accompanied by an attenuation of subclinical inflammation probably due to catecholamine normalization. We failed to demonstrate an involvement of the changes in circulating leptin, adiponectin or resistin levels in this process.
authors.affiliation: Third Department of Medicine, First Faculty of Medicine, Charles University, Praha, Czech Republic.
authors.forename: L
authors.initials: L
authors.lastname: Bosanska
authors.forename: O
authors.initials: O
authors.lastname: Petrak
authors.forename: T
authors.initials: T
authors.lastname: Zelinka
authors.forename: M
authors.initials: M
authors.lastname: Mraz
authors.forename: J
authors.initials: J
authors.lastname: Widimsky
authors.forename: M
authors.initials: M
authors.lastname: Haluzik
mesh_terms: D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000378:metabolism*; D000310:Adrenal Gland Neoplasms / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D000315:Adrenalectomy; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism*; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000517:prevention & control*; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D052243:Resistin / Q000097:blood; D016896:Treatment Outcome; D015430:Weight Gain
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; C499624:RETN protein, human; D052243:Resistin; D002097:C-Reactive Protein