Abnormal fundus autofluorescence patterns in myopic choroidal neovascularisation.
OBJECTIVE
To investigate fundus autofluorescence (FAF) findings in eyes with myopic choroidal neovascularisation (CNV).


METHODS
Observational case series. Twenty-seven consecutive eyes with CNV for at least 1 year were included. FAF patterns, time after the onset of CNV seen on FAF and FAF changes were evaluated.


RESULTS
The following patterns were observed: pattern I (n = 2), relative hypoautofluorescence around the CNV surrounded by hyperautofluorescence a mean of 17 months after CNV onset; pattern II (n = 11), small lobular or multilobular well-defined FAF defects within a relatively hypoautofluorescent region surrounded by hyperautofluorescence a mean of 35 months after onset; pattern III (n = 4), large lobular or multilobular well-defined FAF defects surrounded by hyperautofluorescence a mean of 59 months after onset; and pattern IV (n = 10), large lobular or crescent-shaped well-defined FAF defects a mean of 107 months after onset. Well-defined FAF defects corresponded to chorioretinal atrophy on colour fundus photographs. During the follow-up period, two eyes with pattern I evolved into pattern II. Lobular or multilobular well-defined FAF defects enlarged in 11 eyes (pattern II, nine eyes; pattern III, two eyes).


CONCLUSIONS
Autofluorescent changes progress over time through pattern grading. A pattern classification might be helpful to predict chorioretinal atrophy changes around myopic CNV.
Sawa
M
M
Department of Ophthalmology, Osaka University Medical School, Osaka, Japan. sawamiki@ophthal.med.osaka-u.ac.jp
Gomi
F
F
Tsujikawa
M
M
Ikuno
Y
Y
Sakaguchi
H
H
Sayanagi
K
K
Tano
Y
Y
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000473:pathology*; D009896:Optic Atrophy / Q000175:diagnosis*; D012189:Retrospective Studies