title: Necrotic cell death and 'necrostatins': now we can control cellular explosion.
abstract: The receptor-interacting protein 1 (RIP1) kinase activity is necessary for death-receptor-induced necrotic cell death. Recently, it has been demonstrated that 'necrostatins' efficiently block tumor necrosis factor-induced necrotic cell death through the inhibition of RIP1 kinase activity. This discovery supports the concept that receptor-induced necrosis, just like apoptosis, is a controlled cellular process. In addition, necrostatins are becoming important tools for evaluating the contribution of necrotic cell death in experimental disease models.
authors.affiliation: Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium. Peter.Vandenabeele@dmbr.UGent.be
authors.forename: Peter
authors.initials: P
authors.lastname: Vandenabeele
authors.forename: Wim
authors.initials: W
authors.lastname: Declercq
authors.forename: Tom
authors.initials: T
authors.lastname: Vanden Berghe
mesh_terms: D000818:Animals; D016923:Cell Death; D006801:Humans; D009336:Necrosis; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D053422:Receptor-Interacting Protein Serine-Threonine Kinases