title: Development of a practical Buchwald-Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst.
abstract: Continuing efforts to establish a more general "user-friendly" protocol for the palladium-catalysed arylation of amines (Buchwald-Hartwig reaction) are described herein. Significant advances have been made through the use of the versatile (SIPr)Pd(methallyl)Cl complex in conjunction with the reliable base lithium hexamethyldisilazide (LHMDS).
authors.affiliation: Department of Chemistry, University College London, London, UK.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Cawley
authors.forename: F Geoffrey N
authors.initials: FG
authors.lastname: Cloke
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Fitzmaurice
authors.forename: Stuart E
authors.initials: SE
authors.lastname: Pearson
authors.forename: James S
authors.initials: JS
authors.lastname: Scott
authors.forename: Stephen
authors.initials: S
authors.lastname: Caddick
mesh_terms: D000588:Amines / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009025:Morpholines / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000588:Amines; D001555:Benzene Derivatives; D009025:Morpholines; D009942:Organometallic Compounds; D010165:Palladium; C037574:morpholine