Influence of liver biopsy on abstinence in alcohol-dependent patients.
BACKGROUND
Liver biopsy indication for the evaluation of alcoholic liver disease is controversial. Our aim was to investigate the influence of the biopsy on the patients' motivation for abstinence.


METHODS
We retrospectively analysed, in a population of 324 patients hospitalized for alcohol withdrawal, the impact of liver biopsy on the following clinical outcomes: rapid loss to follow-up (immediately after hospital discharge), early relapse (< 3 months) and long-lasting abstinence (> 12 months). The biopsy was performed in 136 patients who had liver enzymes perturbations. Hepatic lesions were graded as mild (isolated steatosis and/or non-bridging fibrosis), moderate (bridging fibrosis and/or moderate alcoholic hepatitis) or severe (cirrhosis and/or marked alcoholic hepatitis) in 66 (48%), 41 (30%) and 29 (21%) cases, respectively.


RESULTS
In univariate analysis, patients who had a liver biopsy were less likely to be rapidly lost to follow-up (12% versus 27%, P = 0.003) but had a lower rate of long-term abstinence (20% versus 34%, P = 0.025). In multivariate analysis, age was the only factor significantly associated with clinical outcome: older patients had higher rate of long-term abstinence (OR = 1.041; P = 0.010). Among patients who had a biopsy, those with severe hepatic lesions had a lower rate of rapid relapse than those with moderate or mild lesions (32% versus 68% and 56%, P = 0.018) but the rate of long-term abstinence was similar in the three groups.


CONCLUSIONS
This observational study does not support the notion that liver biopsy has a significant influence on the maintenance of alcohol abstinence in patients with alcoholic liver disease.
Trabut
Jean-Baptiste
JB
Unité d'Hépatologie-Hôpital Cochin, 27, rue du Faubourg St Jacques, 75014 Paris, France.
Plat
Arnaud
A
Thepot
Véronique
V
Fontaine
Hélène
H
Vallet-Pichard
Anaïs
A
Nalpas
Bertrand
B
Pol
Stanislas
S
D000328:Adult; D000437:Alcoholism / Q000473:pathology* / Q000523:psychology*; D001706:Biopsy / Q000523:psychology*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000473:pathology* / Q000523:psychology*; D008111:Liver Function Tests; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009042:Motivation; D010297:Paris; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013695:Temperance / Q000523:psychology*