Norditerpenoid alkaloids from the roots of Aconitum heterophyllum   Wall with antibacterial activity.
Two new aconitine-type norditerpenoid alkaloids 6-dehydroacetylsepaconitine (1) and 13-hydroxylappaconitine (2), along with three known norditerpenoid alkaloids lycoctonine, delphatine and lappaconitine were isolated from the roots of the Aconitum heterophyllum Wall. These compounds exhibited significant antibacterial activity. The structure of compound 1 and 2 were deduced on the basis of their spectral data.
Ahmad
Manzoor
M
H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. manzoorhej@yahoo.com
Ahmad
Waqar
W
Ahmad
Mansoor
M
Zeeshan
Muhammad
M
Obaidullah
Shaheen
Farzana
F
D031841:Aconitum / Q000737:chemistry* / Q000145:classification*; D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D004224:Diterpenes