title: Enzymatic phosphatidylation of thiamin, pantothenic acid, and their derivatives.
abstract: Phospholipase D from Streptomyces sp. was found to catalyze the transfer reaction of the dipalmitoylphosphatidyl residue from 1,2-dipalmitoyl-3-sn-phosphatidylcholine to thiamin, pantothenic acid, and their derivatives in a biphasic system. The following phosphatidylated compounds were synthesized: 1,2-dipalmitoyl-3-sn-phosphatidylthiamin, 1,2-dipalmitoyl-3-sn-phosphatidylthiamin propyl disulfide, 1,2-dipalmitoyl-3-sn-phosphatidylthiamin tetrahydrofurfuryl disulfide, 1,2-dipalmitoyl-3-sn-phosphatidylpantothenic acid, and 1,2-dipalmitoyl-3-sn-phosphatidyl-pantothenyl ethyl ether.
authors.affiliation: Research Institute for Bioresources, Okayama University, Kurashiki, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Hidaka
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takami
authors.forename: Yukio
authors.initials: Y
authors.lastname: Suzuki
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000138:chemical synthesis; D002384:Catalysis; D002855:Chromatography, Thin Layer; D015394:Molecular Structure; D010205:Pantothenic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D010713:Phosphatidylcholines / Q000138:chemical synthesis; D010739:Phospholipase D / Q000737:chemistry*; D013831:Thiamine / Q000138:chemical synthesis* / Q000737:chemistry; D013997:Time Factors
chemical_list: D010713:Phosphatidylcholines; D010205:Pantothenic Acid; D015060:1,2-Dipalmitoylphosphatidylcholine; D010739:Phospholipase D; D013831:Thiamine