title: Biotin-rich intranuclear inclusions: have you checked your immunohistochemical controls?
abstract: Intranuclear biotin interacts with avidin-biotin-complex used for viral immunoperoxidase detection giving false-positive results.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Louisville Hospital, Louisville, Kentucky, USA.
authors.forename: Rania
authors.initials: R
authors.lastname: Bakkar
authors.forename: Grace
authors.initials: G
authors.lastname: Moore
authors.forename: Alvin
authors.initials: A
authors.lastname: Martin
authors.forename: Houda
authors.initials: H
authors.lastname: Alatassi
mesh_terms: D000328:Adult; D001710:Biotin / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism / Q000473:pathology*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D045586:Intranuclear Inclusion Bodies / Q000378:metabolism* / Q000473:pathology; D008297:Male; D010920:Placenta / Q000378:metabolism / Q000473:pathology*; D011247:Pregnancy
chemical_list: D001710:Biotin