The centrosome is a polyfunctional multiprotein cell complex.
Contemporary knowledge about centrosome proteins and their ensembles, which can be divided into several functional groups--microtubule-nucleating proteins, microtubule-anchoring proteins, centriole-duplication proteins, cell cycle control proteins, primary cilia growth regulation proteins, and proteins of regulation of cytokinesis--is reviewed. Structural-temporal classification of centrosomal proteins and the scheme of interconnection between the different centrosomal protein complexes are presented.
Alieva
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Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia. irina_alieva@belozersky.msu.ru
Uzbekov
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RE
D000818:Animals; D002502:Centrioles / Q000737:chemistry / Q000378:metabolism; D018385:Centrosome / Q000145:classification / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000145:classification / Q000378:metabolism / Q000502:physiology*; D011485:Protein Binding
D046912:Multiprotein Complexes