title: [Pharmacokinetics of honokiol in rat after oral administration of Cortex of Magnolia officinalis and its compound preparation Houpu Sanwu Decoction].
abstract: OBJECTIVE
  To study pharmacokinetics of honokiol in Cortex of Magnolia officinalis and its compound prescription Houpu Sanwu Decoction (HPSWD) in rat, and discuss the change on pharmacokinetic process affected by other components.
  
  
  METHODS
  The rats were divided into two groups, one was supplied with HPSWD and the other was administrated with Cortex of Magnolia officinalis. Concentrations of honokiol in rat plasma were then determined using HPLC method and main pharmacokinetic parameters were estimated.
  
  
  RESULTS
  The plasma concentrations of honokiol of both groups were conformed to the two-compartment model with first order absorption. There existed significant differences in AUC, C(max), T(max), CL/F among Cortex of Magnolia officinalis and HPSWD.
  
  
  CONCLUSIONS
  The results indicate that Rhubarb and Immature Orange Fruit in HPSWD can influence the asorption, distribution and elimination of honokiol.
authors.affiliation: West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Su
authors.forename: Xi
authors.initials: X
authors.lastname: Huang
authors.forename: Eeig
authors.initials: E
authors.lastname: Qin
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.forename: Ping
authors.initials: P
authors.lastname: Ren
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D001713:Biphenyl Compounds / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D017705:Lignans / Q000097:blood / Q000493:pharmacokinetics*; D031566:Magnolia / Q000737:chemistry*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D001713:Biphenyl Compounds; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D017705:Lignans; C530852:houpu sanwu; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols