Pharmacokinetics of ciprofloxacin in normal rabbits and changes observed in induced dehydrated state.
The pharmacokinetics of ciprofloxacin following oral administration of a single dose of 20 mg/kg body weight was investigated in normal rabbits and changes were observed in water-deprived rabbits. High performance liquid chromatographic method was employed for the determination of plasma concentration of ciprofloxacin. The mean plasma concentration and AUC (0-t) and AUC (0-inf) were significantly different between normal and dehydrated rabbits (P<0.05), but the absorption rate, distribution rate, and elimination rate did not show any statistically significant difference. The results reflect a need for monitoring toxicity of ciprofloxacin in the water-deprived condition.
Bashir
Sajid
S
Department of Pharmacy, University of Balochistan, Quetta, Pakistan.
Jamshaid
Mohammad
M
Ahmad
Bashir
B
Iqbal
Javeid
J
D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D003681:Dehydration / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D011817:Rabbits; D014868:Water Deprivation
D000890:Anti-Infective Agents; D002939:Ciprofloxacin