BMP2 and BMP7 play antagonistic roles in feather induction.
Feathers, like hairs, first appear as primordia consisting of an epidermal placode associated with a dermal condensation that is necessary for the continuation of their differentiation. Previously, the BMPs have been proposed to inhibit skin appendage formation. We show that the function of specific BMPs during feather development is more complex. BMP2 and BMP7, which are expressed in both the epidermis and the dermis, are involved in an antagonistic fashion in regulating the formation of dermal condensations, and thus are both necessary for subsequent feather morphogenesis. BMP7 is expressed earlier and functions as a chemoattractant that recruits cells into the condensation, whereas BMP2 is expressed later, and leads to an arrest of cell migration, likely via its modulation of the EIIIA fibronectin domain and alpha4 integrin expression. Based on the observed cell proliferation, chemotaxis and the timing of BMP2 and BMP7 expression, we propose a mathematical model, a reaction-diffusion system, which not only simulates feather patterning, but which also can account for the negative effects of excess BMP2 or BMP7 on feather formation.
Michon
Frederic
F
Equipe Ontogenèse et Cellules Souches du Tégument, Centre de Recherche INSERM UJF - U823, Institut Albert Bonniot, Site Santé, La Tronche, BP170, 38042 Grenoble Cedex 9, France.
Forest
Loïc
L
Collomb
Elodie
E
Demongeot
Jacques
J
Dhouailly
Danielle
D
D000818:Animals; D019521:Body Patterning / Q000502:physiology; D055396:Bone Morphogenetic Protein 2 / Q000502:physiology*; D055419:Bone Morphogenetic Protein 7 / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002633:Chemotaxis / Q000502:physiology; D002642:Chick Embryo; D020405:Dermis / Q000196:embryology / Q000502:physiology; D004817:Epidermis / Q000196:embryology / Q000502:physiology; D005241:Feathers / Q000196:embryology*; D005353:Fibronectins / Q000378:metabolism; D039441:Integrin alpha4 / Q000378:metabolism; D008954:Models, Biological
D055396:Bone Morphogenetic Protein 2; D055419:Bone Morphogenetic Protein 7; D005353:Fibronectins; D039441:Integrin alpha4