title: Perioperative plasma brain natriuretic peptide and cardiotrophin-1 in off-pump coronary artery bypass.
abstract: OBJECTIVE
  It has been suggested that brain natriuretic peptide (BNP) and cardiotrophin-1 (CT-1) are associated with myocardial dysfunction. The present prospective study was designed to investigate perioperative changes of plasma levels of BNP and CT-1 in off-pump coronary artery bypass (OPCAB).
  
  
  METHODS
  Forty-nine patients undergoing elective OPCAB were divided into three groups. Group I: no previous myocardial infarction; Group II: previous myocardial infarction more than 12 weeks; Group III: recent myocardial infarction within 4-8 weeks. Perioperative BNP and CT-1 levels were measured, and hematochemical parameters were also collected.
  
  
  RESULTS
  Higher preoperative BNP and CT-1 levels were found in group III as compared to those in group I. BNP levels increased after operation, and reached peak value at 3-7 days after the operation. However, the postoperative changes of BNP levels were not different among groups in any time points. CT-1 levels did not change significantly after the operation as compared to baseline.
  
  
  CONCLUSIONS
  Higher BNP and CT-1 levels were associated with recent myocardial infarction. BNP elevated after OPCAB, but CT-1 showed no significant postoperative changes. Postoperative changes of BNP and CT-1 do not associated with cardiac function in OPCAB.
authors.affiliation: Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, P. R. China. minxinw@yahoo.com
authors.forename: Minxin
authors.initials: M
authors.lastname: Wei
authors.forename: Shuo
authors.initials: S
authors.lastname: Ren
authors.forename: Jianshi
authors.initials: J
authors.lastname: Liu
authors.forename: Peijun
authors.initials: P
authors.lastname: Li
authors.forename: Hongyu
authors.initials: H
authors.lastname: Qian
authors.forename: Matti
authors.initials: M
authors.lastname: Tarkka
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D047549:Coronary Artery Bypass, Off-Pump; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D019990:Perioperative Care; D011446:Prospective Studies; D013997:Time Factors; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D016207:Cytokines; D020097:Natriuretic Peptide, Brain; C092073:cardiotrophin 1