The effect of a combination of ampicillin and sulbactam against clinical isolates of anaerobic bacteria.
The antimicrobial susceptibility of 196 recent clinical isolates of anaerobic bacteria to ampicillin alone, ampicillin plus 1 mug/ml sulbactam, ampicillin plus 5 mug/ml sulbactam, and cefoxitin was studied by means of agar dilution tests. The ampicillin/sulbactam combination was most effective against species of the Bacteroides fragilis group, the minimum inhibitory concentration (MIC)(90) of ampicillin plus 5 mug/ml sulbactam for B. fragilis being 1 mug/ml, compared with 256 mug/ml of amoicillin, 4 mug/ml of ampicillin plus 1 mug/ml sulbactam, and 8 mug/ml of cefoxitin. No significant difference between ampicillin alone and in combination with sulbactam was observed against Gram-positive anaerobic rods or cocci.
Werner
H
H
Department of Medical Microbiology, Institute for Hygiene at the University of Tübingen, Germany.
Heizmann
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W
Heilmann
F
F