title: Severe acute haemorrhagic liver failure in a neonate with a favourable spontaneous outcome.
abstract: Acute liver failure in neonates is rare and is frequently associated with an unfavourable outcome. There is no curative treatment other than liver transplantation. Screening for viral, metabolic, toxic or vascular disease is essential to assess the prognosis and to guide specific treatment. Hepatic haemorrhage in neonates is often associated with bacterial infection, trauma and coagulopathies. We present a unique case of neonatal acute liver failure and multifocal massive haemorrhagic intrahepatic lesions of traumatic origin, documented by US and MRI. The patient made a spontaneous recovery. Clinical, biological and imaging outcome was excellent despite the apparent severity of the initial features. The only possible aetiology was a difficult caesarean delivery for mild fetal macrosomia.
authors.affiliation: Service de Radiologie, Hôpital d'enfants Armand-Trousseau, Université Pierre et Marie Curie Paris VI, 26-28 Avenue du docteur Arnold Netter, 75571, Paris Cedex 12, France.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Cavet
authors.forename: Marie
authors.initials: M
authors.lastname: Balu
authors.forename: Catherine
authors.initials: C
authors.lastname: Garel
authors.forename: Delphine
authors.initials: D
authors.lastname: Mitanchez
authors.forename: Sylvain
authors.initials: S
authors.lastname: Renolleau
authors.forename: Marie
authors.initials: M
authors.lastname: Alexandre
authors.forename: Danièle
authors.initials: D
authors.lastname: Pariente
authors.forename: Hubert
authors.initials: H
authors.lastname: Ducou le Pointe
mesh_terms: D006470:Hemorrhage / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D007231:Infant, Newborn; D008107:Liver Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D017114:Liver Failure, Acute / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D012075:Remission, Spontaneous; D014463:Ultrasonography