Neuroendocrine modulation of cancer progression.
Clinical and animal studies now support the notion that psychological factors such as stress, chronic depression, and lack of social support might promote tumor growth and progression. Recently, cellular and molecular studies have started to identify biological processes that could mediate such effects. This review provides a mechanistic understanding of the relationship between biological and behavioral influences in cancer and points to more comprehensive behavioral and pharmacological approaches for better patient outcomes.
Armaiz-Pena
Guillermo N
GN
Department of Gynecologic Oncology, University of Texas, M.D. Anderson Cancer Center, 1155 Herman Pressler, Unit 1362, Houston, TX 77030, USA.
Lutgendorf
Susan K
SK
Cole
Steve W
SW
Sood
Anil K
AK
D000818:Animals; D003863:Depression / Q000503:physiopathology; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D015213:Neuroimmunomodulation / Q000276:immunology / Q000502:physiology; D009490:Neurosecretory Systems / Q000276:immunology / Q000503:physiopathology*; D011598:Psychoneuroimmunology; D013315:Stress, Psychological / Q000276:immunology / Q000503:physiopathology