title: Functional residual capacity breath hold for subtraction image of dynamic liver MRI.
abstract: OBJECTIVE
  In dynamic liver magnetic resonance imaging (MRI) studies, there are problems with misregistration when subtraction images are processed. For reduction of the misregistration, a functional residual capacity (FRC) phase breath-hold (FRC B-H) method was used.
  
  
  METHODS
  Sixty patients (32 males and 28 females, aged 33-85 years, median age 69 years) were examined. The subjects were chronologically categorized into two groups: a voluntary expiratory (VE) B-H group and a FRC B-H group. The blood-flow phase images were classified as plain, arterial, portal and parenchymal phases. To evaluate the reproducibility of liver positions between VE B-H and FRC B-H in each phase (between Plain and Arterial, Arterial and Portal, Plain and Parenchymal), the misregistration areas were compared on the top of the liver.
  
  
  RESULTS
  The misregistration area between Plain-Arterial, Arterial-Portal and Plain-Parenchymal in VE B-H was 731.0+/-1153.6, 1134.9+/-1357.2 and 628.4+/-844.5 (cm(2)), respectively. The misregistration area between each phase in FRC B-H was 386.4+/-874.9, 574.5+/-1086.1 and 279.8+/-551.2 (cm(2)), respectively. Using the Mann-Whitney U-test as quantitative analysis, the difference in misregistration areas between two groups was statistically significant (p<0.05). Differences in the qualitative analysis were also significant according to the chi(2) test (p<0.05).
  
  
  CONCLUSIONS
  The liver positions with FRC B-H were markedly more reproducible than those with VE B-H. To improve the registration accuracy of subtraction dynamic liver MRI, the FRC B-H should be used.
authors.affiliation: Graduate School of Health Sciences, Okayama University, Okayama, Japan; Kawasaki Medical School Kawasaki Hospital, Okayama, Japan. a-tab@po1.oninet.ne.jp
authors.forename: Akihiko
authors.initials: A
authors.lastname: Tabuchi
authors.forename: Toshizo
authors.initials: T
authors.lastname: Katsuda
authors.forename: Mari
authors.initials: M
authors.lastname: Eguchi
authors.forename: Rumi
authors.initials: R
authors.lastname: Gotanda
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Gotanda
authors.forename: Masahiko
authors.initials: M
authors.lastname: Mitani
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takeda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016477:Artifacts; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D015656:Respiratory Mechanics; D012680:Sensitivity and Specificity; D013382:Subtraction Technique