title: Severe reaction to intravenous administration of an ionic iodinated contrast agent in two anesthetized dogs.
abstract: METHODS
  Acute severe systemic reactions developed during i.v. administration of an ionic iodinated contrast agent (iothalamate meglumine) in 2 dogs undergoing contrast-enhanced computed tomography.
  
  
  RESULTS
  Both dogs developed marked changes in heart rate and systolic arterial blood pressure during or immediately after i.v. administration of the contrast agent. The first dog became profoundly hypertensive and bradycardic with poor oxygenation, apparent bronchospasm, and prolonged diarrhea. The second dog became hypotensive and tachycardic with erythema on the ventral aspect of the abdomen and pelvic limbs, periocular edema, and diarrhea.
  
  
  RESULTS
  Both dogs were treated for shock by means of i.v. fluid administration, and anesthesia was discontinued. The first dog was placed on a ventilator to improve oxygenation but was hypertensive and unresponsive for 6.5 hours following contrast agent administration. Bloody diarrhea persisted once consciousness was regained. The dog was discharged 3 days after contrast agent administration, and diarrhea resolved 15 days later. The second dog responded to phenylephrine administration, but urine output appeared low immediately following recovery from anesthesia. Urine output was normal the following day, and the dog was released 36 hours after contrast administration with no residual adverse effects.
  
  
  CONCLUSIONS
  Findings highlighted the potential risk for severe reactions associated with i.v. administration of ionic iodinated contrast agents in dogs. Both hypertensive and hypotensive responses were seen. Supportive care for systemic manifestations was effective in these 2 dogs, and extended hospitalization was not necessary.
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Pollard
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Pascoe
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D003967:Diarrhea / Q000139:chemically induced / Q000628:therapy / Q000662:veterinary; D004283:Dog Diseases / Q000139:chemically induced* / Q000628:therapy; D004285:Dogs; D005260:Female; D005440:Fluid Therapy / Q000662:veterinary; D006339:Heart Rate / Q000187:drug effects*; D007482:Iothalamate Meglumine / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D007482:Iothalamate Meglumine