title: Limbic encephalitis with involvement of prefrontal cortices and persistent amnesia.
abstract: OBJECTIVE
  Most abnormalities on magnetic resonance imaging (MRI) in limbic encephalitis involve the medial temporal lobes and are associated with memory impairment. Recent neuroimaging studies have shown that not only the medial temporal lobes, but also the prefrontal lobes, contribute to cognitive functions.
  
  
  METHODS
  We describe a case of limbic encephalitis with abnormalities in the medial temporal lobes on MRI and decreased accumulation of radionuclide in the prefrontal regions on SPECT.
  
  
  RESULTS
  The patient had persistent retrograde amnesia, particularly affecting remotely acquired memories including public events and autobiographical memories.
  
  
  CONCLUSIONS
  Disruption of the prefrontal-medial temporal circuitry by intense inflammation may have initiated the metabolic changes in the prefrontal cortices, which may exacerbate amnesia.
authors.affiliation: Department of Neurology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, Japan. hk55@naramed-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kataoka
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Furiya
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ueno
mesh_terms: D000647:Amnesia / Q000209:etiology*; D005260:Female; D006801:Humans; D020363:Limbic Encephalitis / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000473:pathology*; D015899:Tomography, Emission-Computed, Single-Photon