title: [A case of hormone/docetaxel-refractory prostate cancer in which PSA level decreased after docetaxel+zoledronic acid treatment].
abstract: The patient was a 63-year-old man who had a recurrence and bone metastasis of prostate cancer after total prostatectomy. He was diagnosed with prostate cancer refractory to hormones. Subsequently, the PSA level decreased after docetaxel therapy, but then gradually increased. Thus, he was diagnosed with bone metastasis of prostate cancer refractory to therapy with hormones or docetaxel. The PSA level decreased after the start of therapy with docetaxel+ zoledronic acid. Zoledronic acid seems to be effective not only for the prevention but also for the treatment of skeletal related events(SRE)in patients with prostate cancer with bone metastases.
authors.affiliation: Dept. of Urology, Chigasaki Municipal Hospital.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Okajima
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Tatsuaki
authors.initials: T
authors.lastname: Onuki
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Fujinami
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Senga
authors.forename: Akihiko
authors.initials: A
authors.lastname: Goto
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Jinza
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Asakura
mesh_terms: D000728:Androgens / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000097:blood / Q000188:drug therapy / Q000556:secondary; D004164:Diphosphonates / Q000627:therapeutic use*; D000077143:Docetaxel; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood* / Q000188:drug therapy* / Q000601:surgery; D043823:Taxoids / Q000627:therapeutic use*; D000077211:Zoledronic Acid
chemical_list: D000728:Androgens; D004164:Diphosphonates; D007093:Imidazoles; D043823:Taxoids; D000077143:Docetaxel; D007987:Gonadotropin-Releasing Hormone; D000077211:Zoledronic Acid; D017430:Prostate-Specific Antigen