Evaluation of in vitro activity of a new fluoroquinolone trovafloxacin (cp-99,219) compared with other anti-anaerobic antimicrobials against members of the Bacteroides fragilis group.
The in vitro activity of a new fluoroquinolone, trovafloxacin (CP-99,219) was compared with that of ten other agents against 100 clinical isolates in the Bacteroides fragilis group. Trovafloxacin was the most active quinolone (MIC(90), 1 microg/ml) followed by sparfloxacin (MIC(90), 8 microg/ml), levofloxacin (MIC(90), 16 microg/ml) and ofloxacin (MIC(90), 32 microg/ml). Ciprofloxacin was the least active quinolone (MIC(90), 64 microg/ml). Metronidazole, chloramphenicol, imipenem and piperacillin/tazobactam, showed excellent activity with an MIC(90) of 1, 8, 0.25 and 16 microg/ml, respectively. Cefoxitin showed good activity and piperacillin was the least active compound. B. vulgatus and B. ovatus were the most resistant species to trovafloxacin among those of the B.fragilis group with an MIC(90) of 4 microg/ml while B. fragilis and B. thetaiotaomicron were the most susceptible (MIC(90), 1 microg/ml).
Borobio
M V
MV
Dpto Microbiologia, Hospital Universitario Virgen Macarena, Universidad de Sevilla, Sevilla, Spain.
Suárez
A I
AI
Ramírez
E
E
Perea
E J
EJ