title: Molecular imaging of PET reporter gene expression.
abstract: Multimodality molecular imaging continues to rapidly expand and is impacting many areas of biomedical research as well as patient management. Reporter-gene assays have emerged as a very general strategy for indirectly monitoring various intracellular events. Furthermore, reporter genes are being used to monitor gene/cell therapies, including the location(s), time variation, and magnitude of gene expression. This chapter reviews reporter gene technology and its major pre-clinical and clinical applications to date. The future appears quite promising for the continued expansion of the use of reporter genes in many evolving biomedically related arenas.
authors.affiliation: Department of Nuclear Medicine, Chonnam National University Medical School, 160 Ilsimri, Hwasun, Jeonnam 519-809, Republic of Korea. jjmin@jnu.ac.kr
authors.forename: Jung-Joon
authors.initials: JJ
authors.lastname: Min
authors.forename: Sanjiv S
authors.initials: SS
authors.lastname: Gambhir
mesh_terms: D000818:Animals; D002465:Cell Movement; D017690:Cell Transplantation; D005786:Gene Expression Regulation; D018390:Gene Targeting; D018014:Gene Transfer Techniques; D017930:Genes, Reporter; D015316:Genetic Therapy; D006801:Humans; D025202:Molecular Diagnostic Techniques; D015335:Molecular Probes / Q000235:genetics / Q000378:metabolism*; D049268:Positron-Emission Tomography; D012815:Signal Processing, Computer-Assisted
chemical_list: D015335:Molecular Probes