title: A preliminary study of thiamine status in northeastern Thai children with acute diarrhea.
abstract: This study is a preliminary determination of thiamine status in children with diarrhea and metabolic acidosis admitted to hospital. Children with diarrhea (N = 14; age 2 m-6 yr) were divided into 2 groups according to anion gap type; group 1 (21.4%) with a normal anion gap (5.5 +/- 5.2 mmol/l) and group 2 (78.6%) with a wide anion gap (21.2 +/- 5.2 mmol/l). Blood was taken on the day of admission to determine thiamine and lactate levels. Sixty-six point seven percent of patients in group 1 had a normal lactate level (1.5 +/- 0.8 mmol/l) and 33.3% had a high lactate level (2.2 mmol/l); none had thiamine deficiency (TPPE < 20%). High lactate (3.5 +/- 1.4 mmol/l) was found in 54.5% of group 2 and thiamine deficiency was observed in 18.2% of this group. In conclusion, no thiamine deficiency was noted in patients with normal anion gap, but thiamine deficiency was not uncommon in patients with a wide anion gap, regardless of lactic acidosis.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Khon Ken University, Khon Kaen 40002, Thailand. patcha_b@kku.ac.th
authors.forename: Patcharee
authors.initials: P
authors.lastname: Boonsiri
authors.forename: Roongpet
authors.initials: R
authors.lastname: Tangrassameeprasert
authors.forename: Charnchai
authors.initials: C
authors.lastname: Panthongviriyakul
authors.forename: Puangrat
authors.initials: P
authors.lastname: Yongvanit
mesh_terms: D000140:Acidosis, Lactic / Q000209:etiology; D000208:Acute Disease; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007223:Infant; D019344:Lactic Acid / Q000032:analysis / Q000097:blood; D008297:Male; D013785:Thailand; D013832:Thiamine Deficiency / Q000097:blood*
chemical_list: D019344:Lactic Acid