[Pathomorphosis of rectal cancer after irradiation on the background of intra-arterial regional chemotherapy].
In cancer recti patients, to whom intraarterial chemotherapy, using fluorouracil, was conducted, in the tumour parenchyma the dystrophic, necrobiotic and necrotic changes are prominent, resulting in the ulcer formation, the parenchyma/stroma ratio disturbance with the stroma prevalence, thickening and petrification foci establishment. As well, the lymphocytes and plasmocytes quantity in stroma is enhancing, witnessing the immune reactions activation. Under the influence of fluorouracil the plasmatic infiltration, hyalinosis and the arteriols lumen obliteration occur. The macrophages reaction, the large quantity of a giant multinuclear cells "foreign bodies" occurrence witness the nonviable state of the tumoral cells.
Bondar
H V
HV
Borota
O V
OV
Kiiashko
O Iu
OIu
Handera
V F
VF
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D010478:Chemotherapy, Cancer, Regional Perfusion; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D011829:Radiation Dosage; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D012007:Rectum / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D016896:Treatment Outcome
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil