Primary vocal cord aspergillosis caused by Aspergillus fumigatus and molecular identification of the isolate.
This is a case of vocal cord aspergillosis in a 36-year-old woman whose chief complaint was progressive hoarseness and vocal fatigue of one month duration. These symptoms followed the use of systemic administration of penicillin, cefotaxime natrium and dexamethasone to treat her rhinitis and asthma. Fiberoptic laryngoscopy revealed whitish plaques involving both vocal cords. Microscopic examination of KOH preparations and histopathology studies of tissue revealed dichotomously branching, hyaline, septate hyphae. Morphological and molecular biological identification of the fungal growth in cultures inoculated with clinical specimens from the patient indicated that the etiologic agent was Aspergillus fumigatus. The patient was cured with oral itraconazole without any side effects.
Ran
Yuping
Y
Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, P. R. China. ranyuping@vip.sina.com
Yang
Baiyan
B
Liu
Suling
S
Dai
Yaling
Y
Pang
Zongguo
Z
Fan
Jiayu
J
Bai
Haoru
H
Liu
Shixi
S
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000382:microbiology* / Q000473:pathology*; D001232:Aspergillus fumigatus / Q000145:classification* / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification*; D001249:Asthma / Q000150:complications* / Q000188:drug therapy; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007828:Laryngoscopy; D012220:Rhinitis / Q000150:complications* / Q000188:drug therapy; D014827:Vocal Cords / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D017964:Itraconazole; D003907:Dexamethasone