title: Cellular uptake and activity of rufloxacin in different cell types and professional phagocytic cells.
abstract: The penetration of the new quinolene rufloxacin into human professional phagocytic cells and different cell types was determined. The intracellular distribution was demonstrated in all cells studied. At 4 degrees C the transport of rufloxacin was reduced. An intracellular dose-dependent activity was demonstrated for rufloxacin in monocytes and granulocytes infected with E. coli and S. aureus. In all the experiments rufloxacin was able to eliminate all intracellular bacteria.
authors.affiliation: Microbiology Institute, Medical School, University of Messina, Messina, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Bonina
authors.forename: A
authors.initials: A
authors.lastname: Arena
authors.forename: M
authors.initials: M
authors.lastname: Cesana
authors.forename: G B
authors.initials: GB
authors.lastname: Costa
authors.forename: F
authors.initials: F
authors.lastname: Mastroeni
authors.forename: M
authors.initials: M
authors.lastname: Carbone