title: Bone alterations during HIV infection.
abstract: Osteopenia and osteoporosis are common in HIV-1-infected individuals and represent a challenge in clinical and therapeutic management. Since the mechanisms underlying this degenerative process are largely unsettled and it has not yet been determined whether bone dysfunction is linked to HIV-1-mediated direct and/or indirect effects on osteoblasts/osteoclasts cross-talk regulation, this brief review analyzes an array of mechanisms that could account for the dramatic bone derangement (bone loss and osteopenia/osteoporosis) during the course of HIV-1 infection.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Bologna, Bologna, Italy. elisa.decrignis@gmail.com
authors.forename: Elisa
authors.initials: E
authors.lastname: De Crignis
authors.forename: Laura
authors.initials: L
authors.lastname: Cimatti
authors.forename: Marco
authors.initials: M
authors.lastname: Borderi
authors.forename: Davide
authors.initials: D
authors.lastname: Gibellini
authors.forename: Maria Carla
authors.initials: MC
authors.lastname: Re
mesh_terms: D000328:Adult; D001851:Bone Diseases, Metabolic / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000453:epidemiology / Q000209:etiology*