title: Ipsilateral motor-related hyperactivity in patients with cerebral occlusive vascular disease.
abstract: OBJECTIVE
  Cerebral occlusive vascular disease is an established risk factor for ischemic stroke; however, little is known about its effects on brain function in patients without stroke. To detect possible functional alterations, we used magnetoencephalography and evaluated cerebral cortical activity during hand motor tasks in a group of such patients. Method- Event-related desynchronization (ERD) during hand-grasping and self-paced finger-tapping tasks was examined in 38 right-hand-dominant patients with occlusive disease of the internal carotid or middle cerebral artery caused by diverse pathologies (atherosclerosis, 28; others, 10) and in 8 control subjects. All patients had no apparent motor impairments. The spatial distribution and the intensity (t value) of ERD in the beta band were analyzed with synthetic aperture magnetometry. According to the laterality index calculated from the ratios of peak t values on ipsilateral vs contralateral (with respect to the hand movement) hemispheres, the distribution of ERD was classified into 3 patterns: contralateral, bilateral, and ipsilateral.
  
  
  RESULTS
  Abnormal ipsilateral dominant distribution of beta ERD was observed significantly more often during contralesional hand grasping in patients with atherosclerotic vascular lesion. It was accompanied by significantly higher t values on the ipsilateral hemisphere, without a decrease in those on the contralateral side. The age, the rating scores of periventricular hyperintensity, and ventricular size were all significantly higher in patients who showed the ipsilateral-dominant pattern.
  
  
  CONCLUSIONS
  Abnormal ipsilateral hyperactivity may indicate the presence of subclinical functional alterations related to atherosclerotic occlusive vascular disease.
authors.affiliation: Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. s-oshino@nsurg.med.osaka-u.ac.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Oshino
authors.forename: Amami
authors.initials: A
authors.lastname: Kato
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hirata
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Kishima
authors.forename: Youichi
authors.initials: Y
authors.lastname: Saitoh
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Fujinaka
authors.forename: Toshiki
authors.initials: T
authors.lastname: Yoshimine
mesh_terms: D000368:Aged; D002340:Carotid Artery Diseases / Q000150:complications; D002560:Cerebrovascular Circulation / Q000502:physiology; D002561:Cerebrovascular Disorders / Q000150:complications*; D003344:Cortical Synchronization; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D006948:Hyperkinesis / Q000209:etiology*; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon