title: Effect of inner ear blood flow changes on the endolymphatic sac.
abstract: CONCLUSIONS
  That the endolymphatic sac (ES) reacts to changes in inner ear blood flow may be important for homeostasis of the inner ear fluid volume and pressure.
  
  
  OBJECTIVE
  To elucidate the effect of changes in inner ear blood flow on the ES and to learn more about the volume and pressure regulatory function of the ES.
  
  
  METHODS
  Epinephrine or sodium nitroprusside (SNP) was injected into the middle ear cavity of adult CBA/J mice. The ES were analyzed morphologically by light microscopy.
  
  
  RESULTS
  Epinephrine reduced the luminal size of the ES leading to an accumulation of intraluminal homogeneous substance. Injection of SNP increased the size of the ES lumen, accompanied by a collapse of the lateral intercellular space (LIS) and dense perisaccular tissue. These changes were almost reversed 4 h after injection.
authors.affiliation: Hiroshima University School of Medicine, Hiroshima, Japan.
authors.forename: Nana
authors.initials: N
authors.lastname: Akagi
authors.forename: Masaya
authors.initials: M
authors.lastname: Takumida
authors.forename: Matti
authors.initials: M
authors.lastname: Anniko
mesh_terms: D000818:Animals; D003051:Cochlea / Q000098:blood supply; D007758:Ear, Inner / Q000098:blood supply*; D004711:Endolymphatic Duct / Q000166:cytology / Q000187:drug effects; D004712:Endolymphatic Sac / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D004837:Epinephrine / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D009599:Nitroprusside / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D013316:Stria Vascularis / Q000166:cytology / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D004837:Epinephrine