title: Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis.
abstract: Eight prenylated xanthones, bannaxanthones A-H (1-8), together with seven known compounds, were isolated from the acetone extract of the twigs of Garcinia xipshuanbannaensis. Their structures were elucidated by spectroscopic data interpretation. The cytotoxic activities of these compounds were evaluated using the MTT method. The results showed that xanthones with an unsaturated prenyl group had stronger cytotoxic activity against cancer cells, whereas those with hydroxylated prenyl groups had none.
authors.affiliation: Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, Hong Kong, PR China.
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Nian-Yun
authors.initials: NY
authors.lastname: Yang
authors.forename: Hong-Lei
authors.initials: HL
authors.lastname: Tian
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Qiao
authors.forename: Jing-Zheng
authors.initials: JZ
authors.lastname: Song
authors.forename: Donald C
authors.initials: DC
authors.lastname: Chang
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Chen
authors.forename: Kathy Q
authors.initials: KQ
authors.lastname: Luo
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Xu
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D029760:Garcinia / Q000737:chemistry*; D006131:Growth Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D044004:Xanthones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D006131:Growth Inhibitors; D044004:Xanthones