title: Towards ethically improved animal experimentation in the study of animal reproduction.
abstract: The ethics of animal-based research is a continuing area of debate, but ethical research protocols do not prevent scientific progress. In this paper, we argue that our current knowledge of the factors that affect reproductive processes provides researchers with a solid foundation upon which they can conduct more ethical research and simultaneously produce data of higher quality. We support this argument by showing how a deep understanding of the genetics, nutrition and temperament of our experimental animals can improve compliance with two of the '3 Rs', reduction and refinement, simply by offering better control over the variance in our experimental model. The outcome is a better experimental design, on both ethical and scientific grounds.
authors.affiliation: UWA Institute of Agriculture M082, The University of Western Australia, Crawley, WA, Australia. dbla@animals.uwa.edu.au
authors.forename: D
authors.initials: D
authors.lastname: Blache
authors.forename: G B
authors.initials: GB
authors.lastname: Martin
authors.forename: S K
authors.initials: SK
authors.lastname: Maloney
mesh_terms: D032761:Animal Experimentation / Q000941:ethics*; D017087:Animal Rights; D000826:Animal Testing Alternatives; D000827:Animal Welfare; D000818:Animals; D000830:Animals, Laboratory; D032984:Ethics, Research; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D008297:Male; D011247:Pregnancy; D012098:Reproduction / Q000502:physiology*; D012106:Research / Q000592:standards; D012107:Research Design