The new challenge of stem cell: brain tumour therapy.
The surprising similarity of much brain tumour behavior to the intrinsic properties of the neural stem/progenitor cell has triggered a recent interest in both arming stem cells to track and help eradicate tumours and in viewing stem cell biology as somehow integral to the emergence and/or production of the neoplasm itself. Moreover, based on the unique capacity of neural stem cells (NSCs) to migrate throughout the brain and to target invading tumour cells, the transplantation of NSCs offers a new potential therapeutic approach as a cell-based delivery system for gene therapy in brain tumours. On the one hand, both stem cells and cancer cells are thought to be capable of unlimited proliferation. While on the other, many tumours and cancer cell lines express stem cell markers, suggesting either that cancer cells resemble stem cells or that cancers contain stem-like cells. In this review we highlight the close relationship between normal neural stem cells and brain tumour stem cells and also suggest the possible clinical implications that these similarities could offer.
Colleoni
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Stem Cell Laboratory, Department of Neurological Science, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Centro Dino Ferrari, Italy.
Torrente
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D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000166:cytology / Q000473:pathology*; D009474:Neurons / Q000166:cytology / Q000473:pathology / Q000502:physiology / Q000637:transplantation; D033581:Stem Cell Transplantation / Q000379:methods*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000502:physiology
D053221:TNF-Related Apoptosis-Inducing Ligand