INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.
The single nucleotide polymorphism (SNP) rs7566605 in the upstream region of the insulin-induced gene 2 (INSIG2) is associated with the obesity phenotype in many Caucasian populations. In Japanese, this association with the obesity phenotype is not clear. To investigate the relationship between rs7566605 and obesity in Japanese, we genotyped rs7566605 from severely obese subjects [n = 908, body mass index (BMI) > or = 30 kg/m2] and normal-weight control subjects (n = 1495, BMI < 25 kg/m2). A case-control association analysis revealed that rs7566605 was significantly associated with obesity in Japanese. The P value in the minor allele recessive mode was 0.00020, and the odds ratio (OR) adjusted for gender and age was 1.61 [95% confidential interval (CI) = 1.24-2.09]. Obesity-associated phenotypes, which included the level of BMI, plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure, were not associated with the rs7566605 genotype. Thus, rs7566605 in the upstream region of the INSIG2 gene was found to be associated with obesity, i.e., severe obesity, in Japanese.
Hotta
Kikuko
K
Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, 1-7-22 Suehiro, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan. kikuko@src.riken.jp.
Nakamura
Michihiro
M
Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, 1-7-22 Suehiro, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.
Nakata
Yoshio
Y
Institute of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan.
Matsuo
Tomoaki
T
Institute of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan.
Kamohara
Seika
S
Medicine and Health Science Institute, Tokyo Medical University, Tokyo, Japan.
Kotani
Kazuaki
K
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Komatsu
Ryoya
R
Rinku General Medical Center, Osaka, Japan.
Itoh
Naoto
N
Toyonaka Municipal Hospital, Osaka, Japan.
Mineo
Ikuo
I
Otemae Hospital, Osaka, Japan.
Wada
Jun
J
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
Masuzaki
Hiroaki
H
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yoneda
Masato
M
Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.
Nakajima
Atsushi
A
Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.
Miyazaki
Shigeru
S
Tokyo Postal Services Agency Hospital, Tokyo, Japan.
Tokunaga
Katsuto
K
Itami City Hospital, Hyogo, Japan.
Kawamoto
Manabu
M
Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.
Funahashi
Tohru
T
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Hamaguchi
Kazuyuki
K
Department of Community Health and Gerontological Nursing, Faculty of Medicine, Oita University, Oita, Japan.
Yamada
Kentaro
K
Department of Medicine, Division of Endocrinology and Metabolism, Kurume University, Fukuoka, Japan.
Hanafusa
Toshiaki
T
First Department of Internal Medicine, Osaka Medical College, Osaka, Japan.
Oikawa
Shinichi
S
Department of Medicine, Division of Endocrinology and Metabolism, Nippon Medical School, Tokyo, Japan.
Yoshimatsu
Hironobu
H
Department of Anatomy, Biology and Medicine, Faculty of Medicine, Oita University, Oita, Japan.
Nakao
Kazuwa
K
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Sakata
Toshiie
T
Department of Anatomy, Biology and Medicine, Faculty of Medicine, Oita University, Oita, Japan.
Matsuzawa
Yuji
Y
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Tanaka
Kiyoji
K
Institute of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan.
Kamatani
Naoyuki
N
Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.|Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo, Japan.
Nakamura
Yusuke
Y
Laboratory for Molecular Medicine, Human Genome Center, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D007564:Japan; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009767:Obesity, Morbid / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
C467727:INSIG2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins