Growth of a human carcinoma of the cervix in mice thymectomized at birth.
Two-week-old neonatally thymectomized CBA mice were given subcutaneous injections of a suspension of 1 x 10(6) human cervical carcinoma cells that had been maintained in vitro for 3 years. Most of these mice developed solid tumors morphologically similar to the original carcinoma. A control group of normal mice given injections of similar cell suspensions did not develop tumors. The solid tumors growing from the cell suspensions were readily transplantable in neonatally thymectomized mice. The ease with which solid tumors arose from cells in suspension probably reflects the markedly defective homograft response of neonatally thymectomized mice. Such animals may serve as a useful model for further studies of the growth characteristics of human tumors in vivo.
Osoba
D
D
Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Auersperg
N
N
D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D013934:Thymectomy; D002583:Uterine Cervical Neoplasms / Q000473:pathology*