title: Acylated pregnane glycosides from Caralluma tuberculata and their antiparasitic activity.
abstract: Five pregnane glycosides were isolated from Caralluma tuberculata (1-5), in addition to a known one (russelioside E, 6). The structures of the isolated compounds were elucidated by the analysis of NMR data and FAB-MS experiments. All the isolated compounds were tested for their antimalarial and antitrypanosomal activities as well as their cytotoxicity against human diploid embryonic cell line (MRC5).
authors.affiliation: Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. abdelsattar@yahoo.com
authors.forename: Essam
authors.initials: E
authors.lastname: Abdel-Sattar
authors.forename: Fathalla M
authors.initials: FM
authors.lastname: Harraz
authors.forename: Soliman Mohammed Abdullah
authors.initials: SM
authors.lastname: Al-ansari
authors.forename: Sahar
authors.initials: S
authors.lastname: El-Mekkawy
authors.forename: Chikara
authors.initials: C
authors.lastname: Ichino
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kiyohara
authors.forename: Aki
authors.initials: A
authors.lastname: Ishiyama
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Otoguro
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
authors.forename: Haruki
authors.initials: H
authors.lastname: Yamada
mesh_terms: D000215:Acylation; D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry* / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D011278:Pregnanes / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000977:Antiparasitic Agents; D006027:Glycosides; D011278:Pregnanes