title: Immunohistochemical study of 3 beta-hydroxysteroid dehydrogenase in dog's perianal sinus.
abstract: In this study, the localization of 3 beta-hydroxysteroid dehydrogenase (3beta-HSD) activity in the wall of canine perianal sinus (PS) was determined. The 3 beta-HSD activity was found out both in the cytoplasm of cells, situated in the propria and forming clusters adjacently to apocrine glands and in the cytoplasm of some epithelial cells in apocrine cells' glands. The results obtained about the 3 beta-HSD activity allowed us to propose a role of this enzyme in PS development and possibly, in tumourogenesis.
authors.affiliation: Department of Veterinary Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria. iv_stefanov@yahoo.com
authors.forename: I
authors.initials: I
authors.lastname: Stefanov
authors.forename: A
authors.initials: A
authors.lastname: Vodenicharov
authors.forename: M
authors.initials: M
authors.lastname: Gulubova
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000818:Animals; D001050:Apocrine Glands / Q000201:enzymology* / Q000378:metabolism; D004285:Dogs; D004847:Epithelial Cells / Q000201:enzymology* / Q000378:metabolism; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male
chemical_list: D015096:3-Hydroxysteroid Dehydrogenases