title: Corticosteroid elimination: the Cincinnati experience.
abstract: Elimination of corticosteroid-related morbidity has been a goal of transplant clinicians from the earliest days of renal transplantation more than 50 years ago. Over the past decade, this goal has begun to be realized. Herein, we describe our efforts to eliminate corticosteroid therapy from maintenance immunosuppression-efforts that have spanned 15 years and have included design and conduct of five multicenter trials and over ten single center trials with over 650 patients at the University of Cincinnati. These efforts have led to a near complete elimination of corticosteroid-related morbidity, and, importantly, a more precise definition of the risk/benefit assessments of corticosteroid withdrawal in individual patient populations, which has allowed individualization and tailoring of corticosteroid-free immunosuppression.
authors.affiliation: University of Cincinnati, the Christ Hospital, Cincinnati, Ohio, USA.
authors.forename: E Steve
authors.initials: ES
authors.lastname: Woodle
authors.forename: Rita
authors.initials: R
authors.lastname: Alloway
authors.forename: Adele
authors.initials: A
authors.lastname: Rike
authors.forename: Prabir
authors.initials: P
authors.lastname: Roy-Chaudhury
authors.forename: Amit
authors.initials: A
authors.lastname: Tevar
authors.forename: Brian
authors.initials: B
authors.lastname: Susskind
authors.forename: Jason
authors.initials: J
authors.lastname: Everly
authors.forename: Gautham
authors.initials: G
authors.lastname: Mogilishetty
authors.forename: Paul
authors.initials: P
authors.lastname: Brailey
authors.forename: Amit
authors.initials: A
authors.lastname: Govil
authors.forename: Steve
authors.initials: S
authors.lastname: Rudich
authors.forename: M Roy
authors.initials: MR
authors.lastname: First
authors.forename: J Wesley
authors.initials: JW
authors.lastname: Alexander
authors.forename: Rino
authors.initials: R
authors.lastname: Munda
authors.forename: Michael
authors.initials: M
authors.lastname: Cardi
authors.forename: Lois
authors.initials: L
authors.lastname: Arend
mesh_terms: D000305:Adrenal Cortex Hormones; D006084:Graft Rejection / Q000453:epidemiology* / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D009017:Morbidity; D015337:Multicenter Studies as Topic; D009820:Ohio / Q000453:epidemiology; D016377:Organ Transplantation; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents