The effect of metoprolol on perioperative outcome in coronary patients undergoing nonvascular abdominal surgery.
OBJECTIVE
To analyze the clinical effectiveness of the beta-1-adrenergic blocker, metoprolol.


METHODS
Prospective, observational, clinical study.


METHODS
Operating room and intensive care unit of a tertiary-care teaching hospital.


METHODS
111 ASA physical status II, III, and IV consecutive patients who were scheduled for open abdominal nonvascular surgery.


METHODS
Patients were divided into two stratification groups: 83 (74.8%) of 111 received metoprolol, and 28 (25.2%) of 111 were controls. Within 24 to 96 hours, the drug was used parenterally in a dose of 5, 10, and 15 mg per 24 hours. Metoprolol cardioprotection was applied during the whole perioperative period, in the form of tablets in a dose of 25, 50, and 100 mg per 24 hours until the 30th postoperative day.


METHODS
During surgery, and in the first 72 postoperative hours, patients were monitored by continuous ST-T segment monitoring. A 12-lead electrocardiogram was attached immediately after surgery; on postoperative days 1, 2, and 7; and one day before discharge from the hospital. Serum troponin-T level was controlled 6, 24, and 96 hours after surgery.


RESULTS
Postoperative mortality of cardiac etiology after 30 days of surgery was 1.2% (1/83) in the metoprolol group versus 7.1% (2/28) in the nonmetoprolol group (P<0.05). The causes of death in these three patients were acute myocardial infarction, congestive heart failure, and malignant arrhythmias.


CONCLUSIONS
Perioperative cardioprotection significantly reduced mortality until postoperative day 30 in patients having open abdominal nonvascular surgery with general anesthesia.
Karapandzic
Vesna Miodrag
VM
Intensive Care Unit, Department of Surgery, Institute for Digestive System Diseases, Clinical Center of Serbia, 11000 Belgrade, Serbia. vemika@eunet.yu
Vujisic-Tesic
Bosiljka D
BD
Pesko
Predrag M
PM
Nenadic
Brankica M
BM
Babic
Dragan D
DD
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D016022:Case-Control Studies; D002423:Cause of Death; D003324:Coronary Artery Disease / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D013505:Digestive System Surgical Procedures; D004562:Electrocardiography; D017052:Hospital Mortality; D006801:Humans; D008790:Metoprolol / Q000494:pharmacology*; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D008790:Metoprolol