A review of fibroblast-populated collagen lattices.
Bell's introduction of the fibroblast-populated collagen lattice (FPCL) has facilitated the study of collagen-cell interactions. As a result of the numerous modifications of the casting of FPCLs, the in vivo applications of these in vitro findings have been confusing. Here experimental FPCL contraction findings are viewed in regard to three proposed mechanisms responsible for lattice contraction. The cellular mechanisms responsible for generating FPCL contraction are cell contraction, cell tractional forces related to cell locomotion, and initial cell elongation and spreading.
Dallon
John C
JC
Department of Surgery, Division of Plastic Surgery, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
Ehrlich
H Paul
HP
D000818:Animals; D015820:Cadherins / Q000502:physiology; D002448:Cell Adhesion; D002450:Cell Communication; D002465:Cell Movement; D002478:Cells, Cultured; D003094:Collagen / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology*; D005347:Fibroblasts / Q000166:cytology* / Q000502:physiology*; D016023:Integrins / Q000502:physiology; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology*
D015820:Cadherins; D016207:Cytokines; D016023:Integrins; D003094:Collagen