Dopamine, kidney, and hypertension: studies in dopamine receptor knockout mice.
Dopamine is important in the pathogenesis of hypertension because of abnormalities in receptor-mediated regulation of renal sodium transport. Dopamine receptors are classified into D(1)-like (D(1), D(5)) and D(2)-like (D(2), D(3), D(4)) subtypes, all of which are expressed in the kidney. Mice deficient in specific dopamine receptors have been generated to provide holistic assessment on the varying physiological roles of each receptor subtype. This review examines recent studies on these mutant mouse models and evaluates the impact of individual dopamine receptor subtypes on blood pressure regulation.
Wang
Xiaoyan
X
Department of Pediatrics, Georgetown University Medical Center, Washington, DC, USA.
Villar
Van Anthony M
VA
Armando
Ines
I
Eisner
Gilbert M
GM
Felder
Robin A
RA
Jose
Pedro A
PA
D000818:Animals; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D011954:Receptors, Dopamine / Q000235:genetics* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D011954:Receptors, Dopamine; D043562:Receptors, G-Protein-Coupled; D012964:Sodium; D004298:Dopamine