title: Estimating the size and dynamics of an injecting drug user population and implications for health service coverage: comparison of indirect prevalence estimation methods.
abstract: OBJECTIVE
  (i) To compare indirect estimation methods to obtain mean injecting drug use (IDU) prevalence for a confined geographic location; and (ii) to use these estimates to calculate IDU and injection coverage of a medically supervised injecting facility.
  
  
  METHODS
  Multiple indirect prevalence estimation methods.
  
  
  METHODS
  Kings Cross, Sydney, Australia.
  
  
  METHODS
  IDUs residing in Kings Cross area postcodes recorded in surveillance data of the Sydney Medically Supervised Injecting Centre (MSIC) between November 2001 and October 2002.
  
  
  METHODS
  Two closed and one open capture-recapture (CRC) models (Poisson regression, truncated Poisson and Jolly-Seber, respectively) were fitted to the observed data. Multiplier estimates were derived from opioid overdose mortality data and a cross-sectional survey of needle and syringe programme attendees. MSIC client injection frequency and the number of needles and syringes distributed in the study area were used to estimate injection prevalence and injection coverage.
  
  
  RESULTS
  From three convergent estimates, the mean estimated size of the IDU population aged 15-54 years was 1103 (range 877-1288), yielding a population prevalence of 3.6% (2.9-4.3%). Mean IDU coverage was 70.7% (range 59.1-86.7%) and the mean adjusted injection coverage was 8.8% (range 7.3-10.8%). Approximately 11.3% of the total IDU population were estimated to be new entrants to the population per month.
  
  
  CONCLUSIONS
  Credible local area IDU prevalence estimates using MSIC surveillance data were obtained. MSIC appears to achieve high coverage of the local IDU population, although only an estimated one in 10 injections occurs at MSIC. Future prevalence estimation efforts should incorporate open models to capture the dynamic nature of IDU populations.
authors.affiliation: Centre for Research on Drugs and Health Behaviour, London School of Hygiene and Tropical Medicine, London, UK. jo.kimber@lshtm.ac.uk
authors.forename: Jo
authors.initials: J
authors.lastname: Kimber
authors.forename: Matthew
authors.initials: M
authors.lastname: Hickman
authors.forename: Louisa
authors.initials: L
authors.lastname: Degenhardt
authors.forename: Tim
authors.initials: T
authors.lastname: Coulson
authors.forename: Ingrid
authors.initials: I
authors.lastname: van Beek
mesh_terms: D000293:Adolescent; D000328:Adult; D001315:Australia / Q000453:epidemiology; D004812:Epidemiologic Methods; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D018671:Needle-Exchange Programs / Q000706:statistics & numerical data; D011157:Population Dynamics; D015995:Prevalence; D016320:Substance Abuse Treatment Centers; D015819:Substance Abuse, Intravenous / Q000453:epidemiology*; D014504:Urban Health