title: Water-mediated catalyst preactivation: an efficient protocol for C-N cross-coupling reactions.
abstract: A protocol for forming a highly active Pd(0) catalyst from Pd(OAc) 2, water, and biaryldialkylphosphine ligands has been developed. This protocol generates a catalyst system, which exhibits excellent reactivity and efficiency in the coupling of a variety of amides and anilines with aryl chlorides.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Room 18-490, Cambridge, Massachusetts 02139, USA.
authors.forename: Brett P
authors.initials: BP
authors.lastname: Fors
authors.forename: Philipp
authors.initials: P
authors.lastname: Krattiger
authors.forename: Eric
authors.initials: E
authors.lastname: Strieter
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
chemical_list: D000577:Amides; D000814:Aniline Compounds; D006843:Hydrocarbons, Chlorinated; D008024:Ligands; D010720:Phosphines; D014867:Water; D010165:Palladium