title: Activation of vocal fold healing with topical vitamin A in rabbits.
abstract: CONCLUSIONS
  The results suggest that vitamin A can prevent scar formation in the vocal fold after surgery.
  
  
  OBJECTIVE
  This study aimed to evaluate the effects of topically applied vitamin A on healing after vocal fold trauma.
  
  
  METHODS
  Vocal folds of 20 adult rabbits were traumatized unilaterally. Ten of them were treated with topical application of vitamin A and the others served as controls. All animals were sacrificed after 10 days. Vocal folds were resected for analysis by light microscopy.
  
  
  RESULTS
  The untreated vocal folds showed extensive deposition of collagen and fibroblast on light microscopy and vocal folds treated with vitamin A showed less deposition. There was a significant difference between the two groups according to the percentage of collagen and fibroblasts in the lamina propria (p<0.01).
authors.affiliation: Ankara Numune Education and Research Hospital, 4th ENT Clinic, Attending Otolaryngolog Ankara, Ankara, Turkey. drozgurakdogan@gmail.com
authors.forename: Ozgur
authors.initials: O
authors.lastname: Akdogan
authors.forename: Adin
authors.initials: A
authors.lastname: Selcuk
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ozcan
authors.forename: Kürsat Murat
authors.initials: KM
authors.lastname: Ozcan
authors.forename: Seren Gulsen
authors.initials: SG
authors.lastname: Giray
authors.forename: Huseyin
authors.initials: H
authors.lastname: Dere
authors.forename: Candan
authors.initials: C
authors.lastname: Ozogul
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002921:Cicatrix / Q000473:pathology / Q000517:prevention & control; D003094:Collagen / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D007820:Laryngeal Mucosa / Q000187:drug effects / Q000473:pathology; D007828:Laryngoscopy; D011817:Rabbits; D014212:Tretinoin / Q000494:pharmacology*; D014827:Vocal Cords / Q000187:drug effects* / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D014212:Tretinoin; D003094:Collagen