Reduced immunoreactivity of tyrosine hydroxylase in the hypothalamic paraventricular nucleus of the seizure sensitive gerbil.
We compared the immunoreactivity and numbers of tyrosine hydroxylase (TH) immunoreactive neurons and neuropil in the paraventricular nucleus (PVN) of the hypothalamus between the seizure sensitive (SS) and seizure resistant (SR) gerbils. The distributional pattern of TH immunoreactivity was similar in both groups: TH immunoreactivity was seen mainly in magnocellular neurons of the PVN. However, total TH immunoreactivity in the neurons and neuropil in the SS gerbils was significantly lower than that in the SR gerbils. In addition, the number of TH immunoreactive neurons in the SS gerbils was also much lower than those in the SR gerbils. These results indicate that SS gerbils have a low TH immunoreactivity in the hypothalamic PVN compared with that in SR gerbils.
Lee
Choong Hyun
CH
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, South Korea.
Choi
Jung Hoon
JH
Chung
Dae Won
DW
Hwang
In Koo
IK
Yoon
Yeo Sung
YS
Won
Moo-Ho
MH
Lee
In Se
IS
D000818:Animals; D004198:Disease Susceptibility; D005849:Gerbillinae / Q000378:metabolism*; D006861:Hydrogen Peroxide; D007106:Immune Sera / Q000276:immunology / Q000378:metabolism; D009474:Neurons / Q000276:immunology* / Q000378:metabolism; D010286:Paraventricular Hypothalamic Nucleus / Q000201:enzymology*; D012640:Seizures / Q000235:genetics / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000276:immunology* / Q000378:metabolism
D007106:Immune Sera; D006861:Hydrogen Peroxide; D014446:Tyrosine 3-Monooxygenase