A review of adherence to drug therapy in patients with overactive bladder.
Drug therapy for overactive bladder (OAB) is associated with improvements in symptoms and quality of life, but the short- and long-term adherence and persistence is suboptimal. In this review we outline methods of measuring, and factors affecting, adherence to pharmacotherapy in patients with OAB. Clinical practice suggests that adherence rates reported in clinical trials are much greater than in real practice. Factors affecting adherence include psychological and social variables that might alter patients' perception of the benefits of taking medication, and the effect of comorbidity and polypharmacy. Whilst there is some evidence that lack of efficacy and side-effects are contributory, these additional factors are also important.
Basra
Ramandeep K
RK
Guys and St Thomas NHS Foundation Trust, and University College London, London, UK.
Wagg
Adrian
A
Chapple
Christopher
C
Cardozo
Linda
L
Castro-Diaz
David
D
Pons
Montserrat Espuna
ME
Kirby
Mike
M
Milsom
Ian
I
Vierhout
Mark
M
Van Kerrebroeck
Philip
P
Kelleher
Con
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D010349:Patient Compliance; D011788:Quality of Life; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
D018727:Muscarinic Antagonists