Pravastatin-induced colitis.
We report an unusual case of pravastatin-induced colitis in an 80-year old lady. Onset of symptoms was noted within 48 h of starting the medication. Colonoscopy revealed diffuse ulceration throughout the colon with relative sparing of the rectum, with the biopsies showing ulceration and inflammation. The patient received a short course of steroid therapy and 5 months after stopping pravastatin, there was complete macroscopic and microscopic resolution of the colonic lesions. Drug interaction of pravastatin with amitryptiline could have resulted in this uncommon complication.
Mukhopadhya
Ashis
A
Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK.
Gilmour
Hugh
H
Plevris
John
J
D000369:Aged, 80 and over; D003092:Colitis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D017035:Pravastatin / Q000009:adverse effects*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017035:Pravastatin