The effects of combined use of glutamine and growth hormone on the bacterial translocation associated with obstructive jaundice.
OBJECTIVE
To investigate the effects of combined use of glutamine and growth hormone on bacterial translocation.


METHODS
The study was performed at the laboratories of the Department of Physiology at Ataturk University Medical School, Erzurum, Turkey between June and September 2007. Forty rats divided into 5 groups of 8, were included in the study. In the study groups, the common bile duct was ligated to obtain obstructive jaundice. The rats in the control group CG were given sodium chloride, in the glutamine group GLG they were given glutamine, in the growth hormone group GHG, growth hormone, and in the glutamine + growth hormone group GLGHG glutamine + growth hormone at equal doses by the same methods. Blood, spleen, liver, lymph node, and cecal content samples were obtained. Total bilirubin TB, alkaline phosphates ALP, and gamma glutamine transferase GGT activities were evaluated.


RESULTS
In the CG, cecal contents were higher than in the GLG, and cecal contents and BT were higher than in the GHG and the GLGHG. The BT rate was the lowest in the GLGHG, with a borderline difference with the values of the GLG and GHG.


CONCLUSIONS
We found that in preventing BT, combined use of glutamine, and growth hormone was more effective than using each of these agents alone.
Celebi
Fehmi
F
Department of General Surgery, Ataturk University School of Medicine, Erzurum, Turkey. fcelebi@atauni.edu.tr
Ozturk
Gurkan
G
Kizilkaya
Mehmet
M
D000818:Animals; D018988:Bacterial Translocation / Q000187:drug effects*; D005973:Glutamine / Q000494:pharmacology*; D013006:Growth Hormone / Q000494:pharmacology*; D041781:Jaundice, Obstructive / Q000150:complications* / Q000382:microbiology*; D051381:Rats; D017208:Rats, Wistar
D005973:Glutamine; D013006:Growth Hormone