Antimicrobial anthraquinones from Morinda angustifolia.
Investigation on Morinda angustifolia resulted in the isolation of a new anthraquinone, 1,8-dihydroxy-2-methyl-3,7-dimethoxyanthraquinone (1), along with five known analogues, lucidin 3-O-beta-primeveroside (2), 1,3-dihydroxy-2-methylanthraquinone (3), lucidin- omega -ethyl ether (4), lucidin-omega-butyl ether (5) and damnacanthol (6). The new compound demonstrated significant antimicrobial activity against Bacillus subtilis, Escherichia coli, Micrococcus luteus, Sarcina lutea, Candida albicans and Saccharomyces sake.
Xiang
Wei
W
Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla, Yunnan 666303, PR China. wxiang@uic.edu
Song
Qi-Shi
QS
Zhang
Hong-Jie
HJ
Guo
Shi-Ping
SP
D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D005658:Fungi / Q000187:drug effects*; D015394:Molecular Structure; D032066:Morinda / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots; D012440:Saccharomyces / Q000187:drug effects
C539397:1,8-dihydroxy-2-methyl-3,7-dimethoxyanthraquinone; D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010936:Plant Extracts