title: Localised radiotherapy for a ferret with possible anal sac apocrine adenocarcinoma.
abstract: A seven-year-old, neutered male ferret was referred to our hospital with two perianal masses (2.4x3.0 and 2.4x3.5 cm, respectively) that had recurred after initial surgical excision. Complete resection of the masses was impossible as there was deep invasion along the rectum. On histopathology, the masses were diagnosed as apocrine adenocarcinoma possibly of anal gland origin based on tumour location. There was marked response to localised radiotherapy using an orthovoltage unit at 4 Gy, twice weekly. No visible mass was detectable after six doses of radiation. However, at that time, pleural effusion was diagnosed and radiotherapy was discontinued. Cytology of a sample of the pleural effusion suggested mesothelioma, and no obvious pulmonary metastasis of anal sac adenocarcinoma were identified on thoracic radiography. The ferret died at home on day 71 after the first admission.
authors.affiliation: Laboratories of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakata
authors.forename: Y
authors.initials: Y
authors.lastname: Miwa
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: T
authors.initials: T
authors.lastname: Sakai
authors.forename: N
authors.initials: N
authors.lastname: Sasaki
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy / Q000662:veterinary*; D000694:Anal Gland Neoplasms / Q000532:radiotherapy*; D000695:Anal Sacs / Q000473:pathology; D000818:Animals; D017809:Fatal Outcome; D005289:Ferrets; D008297:Male; D008654:Mesothelioma / Q000000981:diagnostic imaging / Q000601:surgery / Q000662:veterinary; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000601:surgery / Q000662:veterinary; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging / Q000601:surgery / Q000662:veterinary; D010996:Pleural Effusion / Q000000981:diagnostic imaging / Q000209:etiology / Q000662:veterinary; D011859:Radiography