title: [Study on transdermal absorption characteristics of brucine in vitro].
abstract: OBJECTIVE
  To study the transdermal absorption characteristics of brucine in vitro.
  
  
  METHODS
  The oil-water partition coefficient of brucine was measured. Drug permeation tests were performed through excised rat skin in improved Franz diffusion cell. Brucine concentration in samples was determined by HPLC.
  
  
  RESULTS
  The oil-water partition coefficient of brucine was between 4.05 and 5.02 at different temperatures. The permeation rate of 0.5 and 1 mg/ml brucine solution were (1.83 +/- 0.85) and (3.74 +/- 1.54) microg/cm2 x h, respectively. The cumulative permeation ratio in 24 hours were (51.30 +/- 18.51)% and (50.01 +/- 12. 80)%, respectively.
  
  
  CONCLUSIONS
  The research provides experimental datas for the design of transdermal delivery system of brucine.
authors.affiliation: College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China. chenjun75@163.com
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
authors.forename: Bao-Chang
authors.initials: BC
authors.lastname: Cai
authors.forename: Min-Min
authors.initials: MM
authors.lastname: Hu
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D066298:In Vitro Techniques; D008297:Male; D010539:Permeability; D019999:Pharmaceutical Solutions; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D012995:Solubility; D013331:Strychnine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D031461:Strychnos nux-vomica / Q000737:chemistry*
chemical_list: D019999:Pharmaceutical Solutions; C083806:brucine; D013331:Strychnine