Comparison of in-vitro maturation cycles with and without in-vivo matured oocytes retrieved.
This study compared the embryological characteristics and clinical outcome of in-vitro maturation (IVM) treatment cycles with and without in-vivo matured oocytes collected following human chorionic gonadotrophin (HCG) priming. The patients were administered 10,000 IU of HCG subcutaneously when endometrial thickness reached > or =6 mm and oocyte collection was performed 35-36 h after HCG administration. The clinical outcome and embryological aspects were analysed between IVM cycles with (group 1) and without (group 2) in-vivo matured oocytes. In group 1, three (range 1-12) in-vivo matured oocytes per patient were retrieved on average. The number of good quality embryos derived from in-vivo matured oocytes in group 1 was significantly higher than those derived from in-vitro matured oocytes in group 1 and group 2 (P < 0.05). However, there was no difference between the number of good quality embryos produced from in-vitro matured oocytes in the two groups. There were 12 clinical pregnancies (40.0%) in group 1, and seven pregnancies (23.3%) in group 2. These results suggest that IVM cycles with in-vivo matured oocytes resulted in a good clinical pregnancy rate, which could be explained by the superior quality of embryos derived from the in-vivo matured oocytes.
Son
Weon-Young
WY
McGill Reproductive Centre, Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, Quebec H3A 1A1, Canada. weon-young.son@muhc.mcgill.ca
Chung
Jin-Tae
JT
Demirtas
Ezgi
E
Holzer
Hananel
H
Sylvestre
Camille
C
Buckett
William
W
Chian
Ri-Cheng
RC
Tan
Seang Lin
SL
D000328:Adult; D006063:Chorionic Gonadotropin / Q000378:metabolism; D054885:Cumulus Cells / Q000166:cytology; D004624:Embryo Transfer; D004717:Endometrium / Q000473:pathology; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D066298:In Vitro Techniques; D009865:Oocytes / Q000378:metabolism*; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D016896:Treatment Outcome
D006063:Chorionic Gonadotropin