title: Inhibition and attention in adolescents with nonmanic mood disorders and a high risk for developing mania.
abstract: This study examines psychomotor inhibition, sustained attention, and inhibitory attentional control in adolescents (ages 12-18 years) with a nonmanic mood disorder and with a first-degree relative with bipolar I disorder (MD, N = 20) and demographically matched healthy children of parents without any psychiatric disorder (HC, N = 13). MD participants showed abnormal performance in stop signal reaction time and latency (d = 1.28 and 1.64, respectively), sustained attention response bias (d = 0.75), and color naming speed (d = 0.88). The results indicate that MD participants exhibit psychomotor disinhibition, marginal cognitive slowing and cautious response biases, but no formal deficits in sustained or selective attention.
authors.affiliation: Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati, Cincinnati, OH, USA.
authors.forename: Manpreet K
authors.initials: MK
authors.lastname: Singh
authors.forename: Melissa P
authors.initials: MP
authors.lastname: DelBello
authors.forename: David E
authors.initials: DE
authors.lastname: Fleck
authors.forename: Paula K
authors.initials: PK
authors.lastname: Shear
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Strakowski
mesh_terms: D000293:Adolescent; D001008:Anxiety Disorders / Q000150:complications; D001288:Attention / Q000502:physiology*; D016022:Case-Control Studies; D002648:Child; D005190:Family; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D019964:Mood Disorders / Q000503:physiopathology* / Q000523:psychology*; D009483:Neuropsychological Tests; D011594:Psychometrics; D011930:Reaction Time; D012307:Risk Factors; D018709:Statistics, Nonparametric