title: Drug allergies--unknown dangers to patients.
abstract: BACKGROUND
  Drug hypersensitivity reactions are unpredictable side effects. They are a frequent worry for clinicians of all disciplines. Available clinical and pathological data are scarce, as are diagnosis centers.
  
  
  OBJECTIVE
  To review the unmet needs in drug hypersensitivity clinical and basic research.
  
  
  METHODS
  A literature search was performed and expert opinions in the field were collected.
  
  
  CONCLUSIONS
  Drug hypersensitivity reactions are not so rare adverse events. The mechanisms are multiple and a firm diagnosis is often possible. However, further research is needed.
authors.forename: Pascal
authors.initials: P
authors.lastname: Demoly
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans