title: Comparison of new bone formation, implant integration, and biocompatibility between RGD-hydroxyapatite and pure hydroxyapatite coating for cementless joint prostheses--an experimental study in rabbits.
abstract: This is the first work to report on additional Arginin-Glycin-Aspartat (RGD) coating on precoated hydroxyapatite (HA) surfaces regarding new bone formation, implant bone contact, and biocompatibility compared to pure HA coating and uncoated stainless K-wires. There were 39 rabbits in total with 6 animals for the RGD-HA and HA group for the 4 week time period and 9 animals for each of the 3 implant groups for the 12 week observation. A 2.0 K-wire either with RGD-HA or with pure HA coating or uncoated was placed into the intramedullary canal of the tibia. After 4 and 12 weeks, the tibiae were harvested and three different areas of the tibia were assessed for quantitative and qualitative histology for new bone formation, direct implant bone contact, and formation of multinucleated giant cells. Both RGD-HA and pure HA coating showed statistically higher new bone formation and implant bone contact after 12 weeks than the uncoated K-wire. There were no significant differences between the RGD-HA and the pure HA coating in new bone formation and direct implant bone contact after 4 and 12 weeks. The number of multinucleated giant did not differ significantly between the RGD-HA and HA group after both time points. Overall, no significant effects of an additional RGD coating on HA surfaces were detected in this model after 12 weeks.
authors.affiliation: Department of Trauma Surgery, University Hospital Giessen-Marburg GmbH, Giessen, Germany.
authors.forename: Achim
authors.initials: A
authors.lastname: Bitschnau
authors.forename: Volker
authors.initials: V
authors.lastname: Alt
authors.forename: Felicitas
authors.initials: F
authors.lastname: Böhner
authors.forename: Katharina Elisabeth
authors.initials: KE
authors.lastname: Heerich
authors.forename: Erika
authors.initials: E
authors.lastname: Margesin
authors.forename: Sonja
authors.initials: S
authors.lastname: Hartmann
authors.forename: Andreas
authors.initials: A
authors.lastname: Sewing
authors.forename: Christof
authors.initials: C
authors.lastname: Meyer
authors.forename: Sabine
authors.initials: S
authors.lastname: Wenisch
authors.forename: Reinhard
authors.initials: R
authors.lastname: Schnettler
mesh_terms: D000818:Animals; D001178:Arthroplasty / Q000295:instrumentation; D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes; D001842:Bone and Bones / Q000187:drug effects*; D017886:Durapatite / Q000737:chemistry; D015726:Giant Cells / Q000166:cytology; D020007:Implants, Experimental; D007595:Joint Prosthesis; D009842:Oligopeptides / Q000737:chemistry; D019736:Prostheses and Implants; D011817:Rabbits; D013499:Surface Properties; D013977:Tibia / Q000473:pathology; D014025:Titanium / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid; D017886:Durapatite; D014025:Titanium