Kaempferol, but not resveratrol inhibits angiotensin converting enzyme.
Inhibition of angiotensin converting enzyme (ACE) has proved to be beneficial in the treatment of various cardiovascular disorders. The aim of this study was to evaluate ACE inhibitory potential of two polyphenolic compounds with different structures: resveratrol (present in high quantities in French wine) and kaempferol (abundant in greens), using method of liquid chromatography coupled with electrospray ionization mass spectrometry (LC-ESI-MS) for ex vivo measurement of angiotensin I to angiotensin II conversion by ACE in aortic tissue of Wistar-Kyoto rats. In this setting, kaempferol (10-30-100 microM), but not resveratrol (10-30-100 microM) appeared to inhibit dose-dependently conversion of Ang I to Ang II. Although the mechanism of ACE inhibition by kaempferol remains to be elucidated, this observation may help in search or designing of new classes of ACE inhibitors.
Olszanecki
R
R
Chair of Pharmacology, Jagiellonian University School of Medicine, Krakow, Poland. mfolszan@cyf-kr.edu.pl
Bujak-Gizycka
B
B
Madej
J
J
Suski
M
M
Wołkow
P P
PP
Jawień
J
J
Korbut
R
R
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D044949:Kaempferols / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D051381:Rats; D011921:Rats, Inbred WKY; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D044949:Kaempferols; D013267:Stilbenes; C006552:kaempferol; D007703:Peptidyl-Dipeptidase A; D000077185:Resveratrol