title: In vitro activity of WY-49605, a penem antimicrobial.
abstract: The in vitro activity of the penem antimicrobial WY-49605 was compared with those of other agents available for oral administration. Based on concentrations inhibiting 90% of isolates (MIC(90)s), the penem inhibited methicillin-susceptible staphylococci (MIC(90) = 0.25 microg/ml), penicillin-susceptible streptococci (MIC(90) < or = 0.12 microg/ml) and several other Gram-positive genera at concentrations comparable or superior to the most active comparison agents. WY-49605 and cefpodoxime were the most active agents against members of the family Enterobacteriaceae. Most strains of Enterococcus faecalis and Bacteroides fragilis were susceptible to the new agent at concentrations < or =4microg/ml, while Pseudomonas aeruginosa, Enterococcus faecium, and methicillin-resistant Staphylococcus aureus were resistant to all agents tested.
authors.affiliation: Department of Medicine, Deaconess Hospital One Deaconess Road, Boston, MA 02215, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Eliopoulos
authors.forename: C B
authors.initials: CB
authors.lastname: Wennersten
authors.forename: G
authors.initials: G
authors.lastname: Cole
authors.forename: R C
authors.initials: RC
authors.lastname: Moellering