Concise total synthesis of (+)-crocacin C.
The cytotoxic natural product (+)-crocacin C ( 1) has been synthesized in 10 linear steps from commercially available Evans' chiral propionimide in 5% overall yield (8 steps from Evans' chiral dipropionate synthon). No protecting groups were utilized.
Sirasani
Gopal
G
Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA.
Paul
Tapas
T
Andrade
Rodrigo B
RB
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000475:Alkenes; D000577:Amides; C500918:crocacin C