Malignancy after solid organ transplantation: an overview.
With improving survival following solid organ transplantation, clinicians must be aware of post-transplant complications. One increasingly frequent complication is the development of malignancy after transplantation. The most common malignancies encountered in the post-solid organ transplant setting are nonmelanoma skin cancers, post-transplant lymphoproliferative disorders, and Kaposi's sarcoma (KS). The pathogenesis of these tumors is likely related to the immunosuppressive drugs used post-transplantation and subsequent viral infection. Treatment involves modification of the immunosuppressive drug regimen, resection of localized disease, and chemotherapy. We present the second reported case of a patient with lung transplantation who developed KS in the lung graft.
Zafar
S Yousuf
SY
Divisions of Hematology and Medical Oncology, Duke University Medical Center, 508 Fulton Street (152), Durham, North Carolina 27705, USA. yousuf.zafar@duke.edu
Howell
David N
DN
Gockerman
Jon P
JP
D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D008175:Lung Neoplasms / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D016377:Organ Transplantation / Q000009:adverse effects*; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D012878:Skin Neoplasms / Q000209:etiology / Q000517:prevention & control / Q000628:therapy