Age, family history, and memory and future risk for cognitive impairment.
OBJECTIVE
To provide a clinical tool for calculating a patient's future risk for developing cognitive impairment based on age, family history, and Rey Auditory Verbal Learning Test (AVLT) retention.


METHODS
1,019 cognitively normal persons followed for an average of 5 years; 159 participants were eventually diagnosed with cognitive impairment.


RESULTS
Risk of developing cognitive impairment increases with age and family history, but decreases with better memory performance. A nomogram is provided for calculation of relative risk of developing cognitive impairment in combinations of age, family history, and memory performance.


CONCLUSIONS
These results enhance clinicians' ability to provide information to a patient about risk of cognitive impairment.
Locke
Dona E C
DE
Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, AR 85259, USA. locke.dona@mayo.edu
Ivnik
Robert J
RJ
Cha
Ruth H
RH
Knopman
David S
DS
Tangalos
Eric G
EG
Boeve
Bradley F
BF
Petersen
Ronald C
RC
Smith
Glenn E
GE
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D016001:Confidence Intervals; D005190:Family; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D012307:Risk Factors; D014706:Verbal Learning / Q000502:physiology