[Risk factors for side effects due to the use of antituberculous drugs in elderly patients].
OBJECTIVE
This study was designed to evaluate incidence of clinical risk factors for side effects due to the use of antituberculous drugs.


METHODS
We retrospectively analyzed clinical records of 229 elderly patients with tuberculosis treated at our hospital.


RESULTS
Temporary stop of antituberculous therapy proved to be needed because of side effects in 77 patients (33.6%). Adverse effects leading to drug discontinuation were liver dysfunction (15.7%), gastrointestinal dysfunction (7.0%), and skin rash (5.7%); other effects accounted for discontinuation in 5.2%. Risk factors for liver dysfunction according to Cox proportional hazards regression analysis were complications of HCV infection (hazard ratio or HR, 2.97; 95% confidence interval or CI, 1.20 to 7.38; p=0.019); hepaocellular injury present at admission (HR, 3.37; 95% CI, 1.56 to 7.29; p=0.002); and dose of isoniazid (per mg/kg, HR, 1.40; 95% CI, 1.05 to 1.85; p=0.02). Body mass index was a risk factor for gastrointestinal dysfunction (per kg/m2, HR, 0.83; 95% CI, 0.70 to 0.98; p=0.026).


CONCLUSIONS
Such identification of risk factors for side effects from antituberculous therapy in elderly tuberculosis patients would minimize adverse effects.
Yamamoto
Yoshiaki
Y
Department of Pharmacy, NHO Higashi Nagoya National Hospital, Japan. yamamoty@toumei.hosp.go.jp
Hayashi
Makoto
M
Miyakawa
Keiko
K
Ogawa
Kenji
K
D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors
D000995:Antitubercular Agents