Protein kinase Cepsilon: multiple roles in the function of, and signaling mediated by, the cytoskeleton.
Recent studies have established essential roles of protein kinase Cepsilon in signaling pathways controlling various functions of microfilaments and intermediate filaments by modulating multiple cytoskeletal proteins. This review summarizes recent progress in our understanding of the roles of protein kinase Cepsilon in the functions and signaling of microfilaments and intermediate filaments, with a focus mainly on cell-matrix and cell-cell interactions, migrations and contraction, in addition to its relevance in the development of several diseases, such as malignant tumors or cardiac disease.
Akita
Yoshiko
Y
Department of Laboratory Animal Science, The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan. akita@rinshoken.or.jp <akita@rinshoken.or.jp>
D008841:Actin Cytoskeleton / Q000201:enzymology*; D000818:Animals; D009202:Cardiomyopathies / Q000201:enzymology; D002448:Cell Adhesion; D002465:Cell Movement; D005109:Extracellular Matrix / Q000502:physiology; D016023:Integrins / Q000378:metabolism; D007382:Intermediate Filaments / Q000201:enzymology*; D009369:Neoplasms / Q000201:enzymology; D051744:Protein Kinase C-epsilon / Q000502:physiology*; D015398:Signal Transduction
D016023:Integrins; D051744:Protein Kinase C-epsilon