[Optimization of ligustrazine phosphate thermosensitive gel formulation by central composite design-response surface methodology].
OBJECTIVE
To optimize the formulation of ligustrazine phosphate thermosensitive gel by the central composite design-response surface methodology (RSM plus CCD).


METHODS
In the formulation design using RSM plus CCD, independent variables were the amounts of poloxamer 407 and poloxamer 188, and gel temperature was dependent variable. Multilinear and quadratic models were used to estimate the relationship between the dependent and the independent variables, select the optimal formulations and validate.


RESULTS
The quantitative relationships between two factors and evaluation index were characterized, quadratic model had better prediction capability than multilinear model.


CONCLUSIONS
Quadratic model is performed in the optimization of formulation due to the statistical confidence. The optimization of ligustrazine phosphate thermosensitive gel formulation can be achieved by the central composite design and response surface methodology.
Meng
Dong-Mei
DM
College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xu
Yue-Hong
YH
Ding
Ping-Tian
PT
Deng
Yu-Jiao
YJ
Wei
Min-Yan
MY
D000465:Algorithms; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D005782:Gels; D016014:Linear Models; D020442:Poloxamer / Q000737:chemistry*; D011719:Pyrazines / Q000008:administration & dosage* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature; D014783:Viscosity
D005782:Gels; D011719:Pyrazines; D020442:Poloxamer; C017953:tetramethylpyrazine