Subcellular localization of mRNA and factors involved in translation initiation.
Both the process and synthesis of factors required for protein synthesis (or translation) account for a large proportion of cellular activity. In eukaryotes, the most complex and highly regulated phase of protein synthesis is that of initiation. For instance, across eukaryotes, at least 12 factors containing 22 or more proteins are involved, and there are several regulated steps. Recently, the localization of mRNA and factors involved in translation has received increased attention. The present review provides a general background to the subcellular localization of mRNA and translation initiation factors, and focuses on the potential functions of localized translation initiation factors. That is, as genuine sites for translation initiation, as repositories for factors and mRNA, and as sites of regulation.
Hoyle
Nathaniel P
NP
Faculty of Life Sciences, The Michael Smith Building, The University of Manchester, Oxford Road, Manchester, UK.
Ashe
Mark P
MP
D000818:Animals; D001692:Biological Transport; D005786:Gene Expression Regulation; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism; D006801:Humans; D010442:Peptide Chain Initiation, Translational / Q000235:genetics*; D010448:Peptide Initiation Factors / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*
D020662:Guanine Nucleotide Exchange Factors; D010448:Peptide Initiation Factors; D012333:RNA, Messenger