title: Sensorineural hearing loss in primary antibody deficiency disorders.
abstract: To evaluate the hearing function in patients affected by primary antibody deficiency disorders. Forty-seven patients, 25 of whom were affected by X-linked agammaglobulinemia and 22 of whom were affected by common variable immunodeficiency were evaluated with audiologic tests that included pure tone audiometry, acoustic immittance assessment and auditory brainstem-evoked response. Eighteen patients (38%), 7 with X-linked agammaglobulinemia and 11 with common variable immunodeficiency, showed sensorineural hearing loss, bilateral in 12 and unilateral in 6. Our data underline the high frequency of hearing loss in patients with antibody deficiency and suggest that a systematic audiologic evaluation should be part of the clinical care of these patients.
authors.affiliation: Department of Pediatric Otorhinolaringology, Spedali Civili, Brescia, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Berlucchi
authors.forename: Annarosa
authors.initials: A
authors.lastname: Soresina
authors.forename: Luca O
authors.initials: LO
authors.lastname: Redaelli De Zinis
authors.forename: Luisa
authors.initials: L
authors.lastname: Valetti
authors.forename: Roberta
authors.initials: R
authors.lastname: Valotti
authors.forename: Vassilios
authors.initials: V
authors.lastname: Lougaris
authors.forename: Antonella
authors.initials: A
authors.lastname: Meini
authors.forename: Daria
authors.initials: D
authors.lastname: Salsi
authors.forename: Piero
authors.initials: P
authors.lastname: Nicolai
authors.forename: Alessandro
authors.initials: A
authors.lastname: Plebani
mesh_terms: D000158:Acoustic Impedance Tests; D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications* / Q000276:immunology; D001301:Audiometry, Pure-Tone; D001402:B-Lymphocytes; D002648:Child; D002675:Child, Preschool; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000276:immunology; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D053632:X-Linked Combined Immunodeficiency Diseases / Q000150:complications* / Q000276:immunology
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M