Genetic susceptibility of diabetic retinopathy.
Diabetes continues to be a major source of -morbidity and mortality among working-age adults nationally and internationally. The microvascular complications of diabetes, including diabetic retinopathy, account for a major proportion of disease-associated morbidity and likely contribute to macrovascular complications. Although glycemic control contributes to -susceptibility for diabetic complications, some people with strict control develop these complications, whereas -others with poor control remain complication free. This suggests a genetic contribution to disease development. Although many genes and proteins of vascular growth have been studied in association with diabetic retinopathy, no definitive major predisposing genes or functional consequences of genetic variants have been identified for microvascular complications of the disease. In this article, we review the studies done on candidate genes.
Patel
Shrena
S
Department of Ophthalmology and Visual Sciences, Moran Eye Center, 65 North Medical Drive, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Chen
Haoyu
H
Tinkham
Nicholas H
NH
Zhang
Kang
K
D042683:Angiopoietin-1 / Q000235:genetics; D000818:Animals; D003930:Diabetic Retinopathy / Q000235:genetics* / Q000473:pathology; D004921:Erythropoietin / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D010982:Platelet-Derived Growth Factor / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
D042683:Angiopoietin-1; D010982:Platelet-Derived Growth Factor; D042461:Vascular Endothelial Growth Factor A; D004921:Erythropoietin