G protein-coupled receptor kinase 2 (GRK2) in migration and inflammation.
G protein-coupled receptor kinase 2 (GRK2) is a key modulator of G protein-coupled receptors and other plasma membrane receptors stimulated by chemotactic messengers. On top of that, GRK2 has been reported to interact with a variety of signal transduction proteins related to cell migration such as MEK, Akt, PI3Kgamma or GIT. Interestingly, the levels of expression and activity of this kinase are altered in a number of inflammatory disorders (as rheumatoid arthritis or multiple sclerosis), thus suggesting that it may play an important role in the onset or development of these pathologies. This review summarizes the mechanisms involved in the control of GRK2 expression and function and highlights novel functional interactions of this protein that might help to explain how altered GRK2 levels affects cell migration in different cell types and pathological settings.
Penela
Petronila
P
Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Universidad Autonoma de Madrid, Madrid, Spain.
Murga
Cristina
C
Ribas
Catalina
C
Salcedo
Alicia
A
Jurado-Pueyo
María
M
Rivas
Veronica
V
Aymerich
Ivette
I
Mayor
Federico
F
D000818:Animals; D002465:Cell Movement; D054769:G-Protein-Coupled Receptor Kinase 2 / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000201:enzymology*; D010766:Phosphorylation; D011487:Protein Conformation
D054769:G-Protein-Coupled Receptor Kinase 2