No evidence of association between frontotemporal dementia and major European mtDNA haplogroups.
OBJECTIVE
Mitochondrial DNA (mtDNA) inherited variability (haplogroup/sub-haplogroup) is currently emerging as not being neutral with respect to several complex traits like neurodegenerative diseases. Here we investigated the association of European mtDNA haplogroups/sub-haplogroups with frontotemporal dementia (FTD).


RESULTS
A case-control study was carried out on 114 patients with FTD (68 sporadic and 46 familial) and 180 controls, matched for age, gender and ethnicity. No association was found.


CONCLUSIONS
European mtDNA haplogroups/sub-haplogroups are unlikely to play a major role in the risk of developing the disease.
Rose
G
G
Department of Cell Biology, University of Calabria, Rende, Italy. pinarose@unical.it
Longo
T
T
Maletta
R
R
Passarino
G
G
Bruni
A C
AC
De Benedictis
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004272:DNA, Mitochondrial / Q000145:classification / Q000235:genetics*; D003704:Dementia / Q000453:epidemiology / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged
D004272:DNA, Mitochondrial