title: Use of complex DNA and antibody microarrays as tools in functional analyses.
abstract: While the deciphering of basic sequence information on a genomic scale is yielding complete genomic sequences in ever-shorter intervals, experimental procedures for elucidating the cellular effects and consequences of the DNA-encoded information become critical for further analyses. In recent years, DNA microarray technology has emerged as a prime candidate for the performance of many such functional assays. Technically, array technology has come a long way since its conception some 15 years ago, initially designed as a means for large-scale mapping and sequencing.The basic arrangement, however, could be adapted readily to serve eventually as an analytical tool in a large variety of applications. On their own or in combination with other methods, microarrays open up many new avenues of functional analysis.
authors.affiliation: Division of Functional Genome Analysis, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 580, Heidelberg D-69120, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bauer
authors.forename: Boris
authors.initials: B
authors.lastname: Beckmann
authors.forename: Christian
authors.initials: C
authors.lastname: Busold
authors.forename: Ole
authors.initials: O
authors.lastname: Brandt
authors.forename: Wlad
authors.initials: W
authors.lastname: Kusnezow
authors.forename: Janne
authors.initials: J
authors.lastname: Pullat
authors.forename: Verena
authors.initials: V
authors.lastname: Aign
authors.forename: Kurt
authors.initials: K
authors.lastname: Fellenberg
authors.forename: Robert
authors.initials: R
authors.lastname: Fleischer
authors.forename: Anette
authors.initials: A
authors.lastname: Jacob
authors.forename: Marcus
authors.initials: M
authors.lastname: Frohme
authors.forename: Jörg D
authors.initials: JD
authors.lastname: Hoheisel