Discoid lupus erythematosus (DLE) in a Spitz dog.
A 3-year-old, female Spitz, was presented due to lack of response to therapies with a 6-month history of skin lesions characterized by diffuse erythema and scaling on the dorsal trunk. Physical examination revealed the dog was active and healthy. Skin culture isolated no fungus. Histological examination of skin biopsy specimens revealed interface dermatitis with hydropic degeneration of the basal layers, predominant plasmacytic perivascular accumulation in the dermis, and intensive plasma cell-rich interface mural folliculitis. Moderate CD3-positive lymphocytes infiltrated the superficial dermis. This report may provide unique information of canine discoid lupus erythematosus in an unusual breed with atypical cutaneous lesions.
Goo
Moon-Jung
MJ
Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea.
Park
Jin-Kyu
JK
Hong
Il-Hwa
IH
Yang
Hai-Jie
HJ
Yuan
Dong-Wei
DW
Ki
Mi-Ran
MR
Han
Jung-Youn
JY
Ji
Ae-Ri
AR
Kim
Tae-Hwan
TH
Williams
Bruce H
BH
Jeong
Kyu-Shik
KS
D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry; D008179:Lupus Erythematosus, Discoid / Q000473:pathology / Q000662:veterinary*; D013045:Species Specificity