LC-9018 treatment enhances survival in gram-negative burn wound sepsis.
Mice pretreated with the LC-9018 showed enhanced survival compared to controls when burned and infected with P. aeruginosa and K. pneumoniae strains. Burned skin quantitative bacterial counts in LC-9018 treated and controls were similar but kidney and liver counts of treated mice were significantly lower. Increased peritoneal cell counts in LC-9018 treated groups suggested enhanced survival and lower organ counts resulted from increased microbial clearance. Survival in LC-9018 pretreated P. aeruginosa infected burned mice was reduced in neutropenic or macrophage blockaded mice which supported this hypothesis. Burned mice treated with LC-9018 at times postburn but pre-P. aeruginosa infection showed significantly enhanced survival. Thus LC-9018 treatment might be useful for increasing survival from burn wound sepsis and further investigation is warranted.
Holder
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Shriners Burns Institute, 3229 Bumet Avenue, Cincinnati, OH 45229, USA.
Miller
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Neely
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