Pellet starters in layering technique using concentrated drug solution.
Characteristics of inert starters in drug solution layering are important for successful active pellet formation. Four types of starters composed of sucrose or microcrystalline cellulose (MCC) or lactose and MCC were compared in our study. The active pellets were prepared using Wurster type apparatus. Yield and pellet quality parameters were determined. The highest yield (85.66-89.41%) was obtained for cores composed of MCC due to their insolubility in water (the drug solvent) and good mechanical properties. On the contrary, soluble and brittle sucrose cores dissolved partially during the process forming undesirable agglomerates and giving lower yield (76.2%). All pellet samples showed good flow properties and drug content from 82.4 to 94.5% of the theoretical drug amount.
Gryczová
Eva
E
Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
Rabisková
Miloslava
M
Vetchý
David
D
Krejcová
Katerina
K
D001696:Biomechanical Phenomena; D002482:Cellulose / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry*; D010316:Particle Size; D012996:Solutions; D013395:Sucrose / Q000737:chemistry*; D013678:Technology, Pharmaceutical
D012996:Solutions; D013395:Sucrose; D002482:Cellulose; D007785:Lactose; C109691:microcrystalline cellulose