Eosinophilic colitis in a patient with advanced transitional cell carcinoma of the bladder: a paraneoplastic syndrome?
Eosinophilia associated with tumors is extremely rare. The exact underlying pathogenetic mechanisms are not well understood; limited data have been reported about granulocyte colony-stimulating factor and interleukin-5 in the development of eosinophilia. We report a patient with marked eosinophilia, leukocytosis, and eosinophilic colitis presenting with bloody stool. The subsequent diagnosis was advanced high-grade transitional cell carcinoma of the bladder. Leukocyte count, eosinophil count, and colonoscopic findings returned to normal after surgical removal of the tumor. To our knowledge, eosinophilic colonic infiltration as a manifestation of transitional cell bladder carcinoma has not been previously reported.
Uyar
Mehtap Erkmen
ME
Department of Internal Medicine, Gastroenterology, and Radiology, Faculty of Medicine, Fatih University, Ankara, Turkey. mehtap94@yahoo.com
Turkay
Cansel
C
Erbayrak
Mustafa
M
Koktener
Asli
A
D002295:Carcinoma, Transitional Cell / Q000150:complications* / Q000601:surgery; D003092:Colitis / Q000150:complications*; D004802:Eosinophilia / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000150:complications* / Q000601:surgery