Resveratrol reduces infarct size and improves ventricular function after myocardial ischemia in rats.
The purpose of this study was to investigate the effect of resveratrol, a polyphenol present in grapes and red wine, on ventricular remodeling after myocardial infarction (MI) in rats. After permanent ligation of the left anterior descending artery, surviving rats were randomly allocated to three groups and treated with 1 mg/kg/day resveratrol (R-1 group), 0.1 mg/kg/day resveratrol (R-0.1 group), or vehicles (control group) administered by intraperitoneal injection once daily for four weeks. We examined the effects of resveratrol by echocardiography, hemodynamic studies, histologic examinations, and real-time quantitative polymerase chain reaction. The R-1 group had significantly increased fractional shortening of the left ventricle, ameliorated left ventricular dilatation, reduced left ventricular end-diastolic pressure, and reduced infarct size. In contrast, the R-0.1 group experienced no beneficial effects on myocardial infarction. The R-1 group also had significantly attenuated expression of myocardial atrial natriuretic peptide and transforming growth factor-beta1 mRNAs. This study indicates that resveratrol is a potent cardioprotective agent in MI rats. Its cardioprotective effects may be due to a reduction of atrial natriuretic peptide and transforming growth factor-beta1, which are known to protect the heart from detrimental remodeling.
Lin
Jeng-Feng
JF
Department of Cardiology, Buddhist Tzu-Chi Hospital, Taipei branch and Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
Lin
Su-Man
SM
Chih
Chun-Lien
CL
Nien
Mao-Wei
MW
Su
Hsin-Hui
HH
Hu
Bo-Ruei
BR
Huang
Shiang-Suo
SS
Tsai
Shen-Kou
SK
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D009320:Atrial Natriuretic Factor / Q000235:genetics / Q000378:metabolism; D024042:Collagen Type I / Q000235:genetics / Q000378:metabolism; D004452:Echocardiography; D006439:Hemodynamics; D008297:Male; D051379:Mice; D017202:Myocardial Ischemia / Q000378:metabolism / Q000473:pathology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism; D020257:Ventricular Remodeling / Q000187:drug effects*
D000975:Antioxidants; D024042:Collagen Type I; D013267:Stilbenes; D053773:Transforming Growth Factor beta1; D009320:Atrial Natriuretic Factor; D000077185:Resveratrol