title: Synthesis of azatricyclodiones & octahydro-benzo[f]isoindoles and their antimicrobial evaluation.
abstract: A series of azatricyclodiones and octahydro-benzo[f]isoindoles have been synthesized by (4+2) Diels-Alder cycloaddition of maleimides with furfuryl amine. Reaction of azatricyclodiones with isocyanates led to the respective ureides. All of the compounds were screened against a number of bacteria and fungi. One of the compounds (2) displayed moderate antitubercular activity while two compounds (2) and (4) inhibited the fungal growth at 25 μg/mL.
authors.affiliation: Medicinal and Process Chemistry Division Central Drug Research Institute, Lucknow, 226001, India.
authors.forename: Nisha
authors.initials: N
authors.lastname: Saxena
authors.forename: Nimisha T
authors.initials: NT
authors.lastname: Singh
authors.forename: Mridul
authors.initials: M
authors.lastname: Mishra
authors.forename: G B Shiva
authors.initials: GB
authors.lastname: Keshava
authors.forename: Praveen Kumar
authors.initials: PK
authors.lastname: Shukla
authors.forename: Rama Pati
authors.initials: RP
authors.lastname: Tripathi
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D061565:Cycloaddition Reaction; D005658:Fungi / Q000187:drug effects; D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000995:Antitubercular Agents; D001372:Aza Compounds; D054833:Isoindoles