[Application of somatostatin combined with oral vancomycin in the treatment of intestinal obstruction after liver transplantation].
OBJECTIVE
To investigate the effect of somatostatin combined with oral vancomycin in the treatment of intestinal obstruction after liver transplantation.


METHODS
Fifty-eight cases of intestinal obstruction after liver transplantation from Jan. 2005 to Dec. 2006 were divided into two groups: Group A (from Jan. 2005 to Dec. 2005) received traditional treatment, including fasting,gastrointestinal decompression, maintaining electrolyte and acid-base balance, enteral and parenteral nutrition support and antibiotics; Group B (from Jan. 2006 to Dec. 2006) received somatostatin combined oral vancomycin in addition to the above mentioned traditional treatment.


RESULTS
Fifty-eight cases out of 441 patients (13%) suffered from intestinal obstruction after liver transplantation. Group B had a better outcome as compared with Group A, including a quick recovery of flatus and stool, [(7.1+/-2.0) d and (8.4+/-2.4) d vs (9.1+/-3.0) d and (10.8+/-3.4) d] (P<0.05), less amount of gastric drainage [(298+/-58) ml/d vs (485+/-106) ml/d](P<0.05). The rate of intestinal flora imbalance in Group B was 55%, which was significantly less than the 77% in Group A(P<0.05).


CONCLUSIONS
The application of somatostatin combined with oral vancomycin can improve the symptoms of intestinal obstruction after liver transplantation and decrease the rate of intestinal flora imbalance.
Cai
Chang-Jie
CJ
Liver Transplantation Center, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Li
Min-Ru
MR
Yi
Shu-Hong
SH
Wang
Gen-Shu
GS
Lu
Min-Qiang
MQ
Chen
Gui-Hua
GH
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007415:Intestinal Obstruction / Q000188:drug therapy* / Q000209:etiology; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*; D013004:Somatostatin / Q000627:therapeutic use*; D014640:Vancomycin / Q000627:therapeutic use*; D055815:Young Adult
D013004:Somatostatin; D014640:Vancomycin