In vivo antiplasmodial activity of 11(13)-dehydroivaxillin from Carpesium ceruum.
The whole plants of Carpesium genus are used in traditional medicine as anti-pyretic, analgesic and vermifugic, including a topical application for sores and inflammation. A previous study on Carpesium genus suggested that the antiplasmodial activity against Plasmodium falciparum was due to the existence of 11(13)- dehydroivaxillin (DDV) from EtOAc extracts of C. ceruum (Compositae). Here, the antimalarial activity of DDV was evaluated against Plasmodium berghei in mice. The LD(50) of the compound was determined as 51.2 mg/kg, while doses of 124 mg/kg and above were found to be lethal to mice. DDV (2, 5, 10 mg/kg/day) exhibited a significant blood schizontocidal activity in 4-day early infection, repository evaluation and in an established infection with a significant mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. DDV possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.
Kim
Jong-Jin
JJ
Department of Environmental Science, Kon Kuk University, Seoul 143-701, South Korea.
Chung
Ill-Min
IM
Jung
Jae-Chul
JC
Kim
Min-Young
MY
Moon
Hyung-In
HI
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D008288:Malaria / Q000188:drug therapy; D020714:Maximum Tolerated Dose; D051379:Mice; D010936:Plant Extracts; D010946:Plants, Medicinal; D010962:Plasmodium berghei / Q000187:drug effects; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D015996:Survival Rate
C539173:11(13)-dehydroivaxillin; D000962:Antimalarials; D010936:Plant Extracts; D012717:Sesquiterpenes