title: Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles.
abstract: A series of novel actinonin derivatives containing a benzimidazole heterocycle linked as amide isostere have been designed and synthesized. The structures of all the synthesized compounds were confirmed by analytical and spectroscopic methods. All the compounds were evaluated in vitro against Staphylococcus aureus, Klebsiella pneumoniae, and Sarcina lutea. Among them, compound 1a with unsubstituted benzimidazole ring exhibited potent antibacterial activities.
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, 27 Shanda Nanlu, Jinan, Shandong 250100, PR China.
authors.forename: Datong
authors.initials: D
authors.lastname: Zhang
authors.forename: Zongheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Weiren
authors.initials: W
authors.lastname: Xu
authors.forename: Fanggang
authors.initials: F
authors.lastname: Sun
authors.forename: Lida
authors.initials: L
authors.lastname: Tang
authors.forename: Jianwu
authors.initials: J
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001562:Benzimidazoles / Q000737:chemistry*; D015195:Drug Design; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012505:Sarcina / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; D006877:Hydroxamic Acids; C010531:actinonin