HIV and chemokine binding to red blood cells--DARC matters.
A mutation in the Duffy antigen (DARC) that abrogates receptor expression and gives profound protection against some malaria species has become almost universal in African populations. He et al. (2008) show that this polymorphism also leads to significantly increased susceptibility to HIV-1 infection but, paradoxically, to prolonged survival in HIV-1-infected subjects.
Walton
Robert T
RT
MRC Laboratories Atlantic Road, PO Box 273 Banjul, The Gambia, West Africa.
Rowland-Jones
Sarah L
SL
D018925:Chemokines / Q000378:metabolism*; D004198:Disease Susceptibility; D004375:Duffy Blood-Group System / Q000096:biosynthesis* / Q000235:genetics; D004912:Erythrocytes / Q000821:virology*; D006678:HIV / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics
C473745:ACKR1 protein, human; D018925:Chemokines; D004375:Duffy Blood-Group System; D011956:Receptors, Cell Surface