title: Importance of type II secretion for survival of Legionella pneumophila in tap water and in amoebae at low temperatures.
abstract: Legionella pneumophila type II secretion mutants showed reduced survival in both tap water at 4 to 17 degrees C and aquatic amoebae at 22 to 25 degrees C. Wild-type supernatants stimulated the growth of these mutants, indicating that secreted factors promote low-temperature survival. There was a correlation between low-temperature survival and secretion function when 12 additional Legionella species were examined.
authors.affiliation: Department of Microbiology and Immunology, Northwestern University Medical School, Chicago, IL 60611, USA.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Söderberg
authors.forename: Jenny
authors.initials: J
authors.lastname: Dao
authors.forename: Shawn R
authors.initials: SR
authors.lastname: Starkenburg
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Cianciotto
mesh_terms: D048248:Acanthamoeba castellanii / Q000382:microbiology*; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D003080:Cold Temperature; D006249:Hartmannella / Q000382:microbiology*; D016952:Legionella pneumophila / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D050296:Microbial Viability; D009154:Mutation; D014871:Water Microbiology
chemical_list: D001426:Bacterial Proteins