Radical scavengers for elderly patients with age-related hearing loss.
CONCLUSIONS
The results of this study suggest that treatment with radical scavengers has the potential to become an effective new therapy for age-related hearing loss.


OBJECTIVE
To assess the efficacy of treatment with radical scavengers for age-related hearing loss.


METHODS
Rebamipide (300 mg/day), alpha-lipoic acid (60 mg/day), and vitamin C (600 mg/day) were given orally for at least 8 weeks to 46 elderly patients with age-related hearing loss.


RESULTS
Hearing levels after treatment were significantly improved at all frequencies.
Takumida
Masaya
M
Department of Otolaryngology, Hiroshima University School of Medicine, 1-2-3 Kasumicho, Minamiku, Hiroshima, Japan. masati@hiroshima-u.ac.jp
Anniko
Matti
M
D000368:Aged; D000369:Aged, 80 and over; D000409:Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001301:Audiometry, Pure-Tone; D004359:Drug Therapy, Combination; D007758:Ear, Inner / Q000187:drug effects; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010865:Pilot Projects; D011304:Presbycusis / Q000188:drug therapy*; D015363:Quinolones / Q000627:therapeutic use*; D012684:Sensory Thresholds / Q000187:drug effects; D008063:Thioctic Acid / Q000627:therapeutic use*
D016166:Free Radical Scavengers; D015363:Quinolones; D008063:Thioctic Acid; C052785:rebamipide; D000409:Alanine; D001205:Ascorbic Acid