title: Association of glucose transporter 1 polymorphisms with type 2 diabetes in the Tunisian population.
abstract: BACKGROUND
  T2DM is a complex metabolic disease. Genetic studies on T2DM have been of little help so far because several genetic association studies have shown conflicting results. In this study, we report the findings of a case-control study on three SNPs in the GLUT1 gene. For this, we investigated the association of GLUT1 genotypes and haplotypes with T2DM.
  
  
  METHODS
  All 273 T2DM subjects (cases) and 343 healthy subjects (controls) were genotyped using the polymerase chain reaction restriction fragment length polymorphism.
  
  
  RESULTS
  Results showed that the GT genotype of XbaI SNP could increase the risk of susceptibility to T2DM to 2.4 and that TAT is a 'risk haplotype' conferring a risk of 3.4 to T2DM.
  
  
  CONCLUSIONS
  The TAT haplotype of the GLUT1 gene confers susceptibility to T2DM in the Tunisian population.
authors.affiliation: Research Unit 'Targets for Diagnostic and Therapy of Human Diseases', Centre of Biotechnology of Sfax, and Laboratoire International Associé No 135, Sfax, Tunisia. kaouthar2005@gmail.com
authors.forename: K
authors.initials: K
authors.lastname: Makni
authors.forename: F
authors.initials: F
authors.lastname: Mnif
authors.forename: M
authors.initials: M
authors.lastname: Boudawara
authors.forename: N
authors.initials: N
authors.lastname: Hamza
authors.forename: N
authors.initials: N
authors.lastname: Rekik
authors.forename: M
authors.initials: M
authors.lastname: Abid
authors.forename: A
authors.initials: A
authors.lastname: Rebaï
authors.forename: F
authors.initials: F
authors.lastname: Jarraya
authors.forename: C
authors.initials: C
authors.lastname: Granier
authors.forename: H
authors.initials: H
authors.lastname: Ayadi
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D051272:Glucose Transporter Type 1 / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014416:Tunisia / Q000453:epidemiology
chemical_list: D051272:Glucose Transporter Type 1; C495677:SLC2A1 protein, human