title: HIV and chemokine binding to red blood cells--DARC matters.
abstract: A mutation in the Duffy antigen (DARC) that abrogates receptor expression and gives profound protection against some malaria species has become almost universal in African populations. He et al. (2008) show that this polymorphism also leads to significantly increased susceptibility to HIV-1 infection but, paradoxically, to prolonged survival in HIV-1-infected subjects.
authors.affiliation: MRC Laboratories Atlantic Road, PO Box 273 Banjul, The Gambia, West Africa.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Walton
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Rowland-Jones
mesh_terms: D018925:Chemokines / Q000378:metabolism*; D004198:Disease Susceptibility; D004375:Duffy Blood-Group System / Q000096:biosynthesis* / Q000235:genetics; D004912:Erythrocytes / Q000821:virology*; D006678:HIV / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C473745:ACKR1 protein, human; D018925:Chemokines; D004375:Duffy Blood-Group System; D011956:Receptors, Cell Surface