title: A study of the relationship between Helicobacter pylori microbial susceptibility, 13C-urea breath test values.
abstract: OBJECTIVE
  Diagnostic methods for Helicobacter pylori (H. pylori) infection can be divided into invasive endoscopic methods and non-invasive methods. A typical and widely used non-invasive method is the 13C urea breath test (UBT). In this study, the possibility of a correlation between pre-treatment UBT values with H. pylori antimicrobial resistance is investigated.
  
  
  METHODS
  The subjects were 119 consecutive patients who attended this hospital for H. pylori testing. Average age was 47.5 +/- 13.2 years, with a male:female ratio of 2.05:1. The diagnosis was gastric ulcer in 43 subjects, duodenal ulcer in 27, gastroduodenal ulcer in 21 and chronic gastritis in 28. Subjects underwent UBT as well as upper gastrointestinal endoscopy (UGITE). The diagnosis of H. pylori infection was examined by the results of culture, histological examination and the rapid urease test (RUT). The mean inhibitory concentration (MIC) was determined for each antimicrobial agent in the bacterial isolates that could be cultured.
  
  
  RESULTS
  In this study, the sensitivity and specificity were excellent at 97.0% and 100% with a cut-off point of 3.5 per thousand for UBT respectively. Clarithromycin resistance was more common in the group with high UBT values. No correlation at all was seen between UBT values and metronidazole, sparafloxacin, cefaclor and amoxicillin susceptibility.
  
  
  CONCLUSIONS
  It is possible that UBT values also tend to be higher in cases of CAM resistance.
authors.affiliation: Endoscopy Center, Tokyo Medical University Hospital, Tokyo, Japan. t-kawai@tokyo-med.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawai
authors.forename: Kohei
authors.initials: K
authors.lastname: Kawakami
authors.forename: Mikinori
authors.initials: M
authors.lastname: Kataoka
authors.forename: Takao
authors.initials: T
authors.lastname: Itoi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Takei
authors.forename: Fuminori
authors.initials: F
authors.lastname: Moriyasu
authors.forename: Yu
authors.initials: Y
authors.lastname: Takagi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Aoki
authors.forename: Hiromi
authors.initials: H
authors.lastname: Serizawa
authors.forename: Emiko
authors.initials: E
authors.lastname: Rimbard
authors.forename: Norihisa
authors.initials: N
authors.lastname: Noguchi
authors.forename: Masanori
authors.initials: M
authors.lastname: Sasatsu
mesh_terms: D001944:Breath Tests; D002247:Carbon Isotopes; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D014508:Urea / Q000032:analysis* / Q000378:metabolism*
chemical_list: D002247:Carbon Isotopes; D014508:Urea