title: Intraductal papillary mucinous neoplasm of the pancreas: assessment of the likelihood of invasiveness with multisection CT.
abstract: OBJECTIVE
  To evaluate the capabilities of multisection computed tomography (CT) in determining the likelihood of invasiveness of intraductal papillary mucinous neoplasm (IPMN).
  
  
  METHODS
  The institutional review board approved this research and waived informed consent from the patients. Two radiologists blinded to the pathologic assessment of malignancy or parenchymal invasion of IPMN retrospectively evaluated CT images of 61 consecutive surgically resected tumors (26 adenomas, 15 noninvasive carcinomas, and 20 invasive carcinomas) in patients who underwent multiphase contrast material-enhanced CT with 0.5- or 1-mm collimation. The findings were statistically analyzed by using univariate and multivariate analyses, with the optimal cutoff levels of each continuous parameter determined by generating receiver operating characteristic curves.
  
  
  RESULTS
  The following findings showed significant differences among the three groups: maximum diameter of the main pancreatic duct (MPD), size (length of major axis) of the largest mural nodule in the MPD or in any associated cystic lesion, abnormal attenuating area in the surrounding parenchyma, calcification in the lesion, protrusion of the MPD into the ampulla of Vater, and bile duct dilatation. An MPD diameter of 6 mm or larger, a mural nodule of 3 mm or larger, and an abnormal attenuating area were independently predictive of malignancy. A mural nodule of 6.3 mm or larger in the MPD and an abnormal attenuating area were independently predictive of parenchymal invasion. According to these criteria, the sensitivity, specificity, and accuracy for identifying malignancy were 83%, 81%, and 82% and for identifying parenchymal invasion were 90%, 88%, and 89%, respectively.
  
  
  CONCLUSIONS
  Multisection CT is useful for distinguishing among adenoma, noninvasive carcinoma, and invasive carcinoma in patients with IPMN.
authors.affiliation: Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8560, Japan. ogawa.hiroshi@h.mbox.nagoya-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogawa
authors.forename: Shigeki
authors.initials: S
authors.lastname: Itoh
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ikeda
authors.forename: Kojiro
authors.initials: K
authors.lastname: Suzuki
authors.forename: Shinji
authors.initials: S
authors.lastname: Naganawa
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000000981:diagnostic imaging*; D000236:Adenoma / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging*; D018300:Papilloma, Intraductal / Q000000981:diagnostic imaging*; D011856:Radiographic Image Enhancement / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D014057:Tomography, X-Ray Computed / Q000379:methods*