[Adrenergic reactivity and course of the wound process in diabetes mellitus condition: diagnostic significance and pathogenetic interpretation].
In order to establish interrelationship between the organism adrenoreactivity and the wound process course in presence of diabetes mellitus the dynamics of effective concentration of alpha2-adrenoreceptors agonist (alpha2-AR), causing aggregation of 50% of thrombocytes (EC50) in patients, suffering diabetes mellitus, complicated by purulent-necrotic affection of lower extremities in admission to the hospital and during the period of treatment, was studied. The cutaneous wounds healing was accompanied by the organism adrenoreactivity normalization, in condition of durable unhealing of the wound the alpha2-AR sensitivity tolerance to the therapy performed was noted. It permits to consider the EC50 index as a criterion of severity of dysregulation changes and the therapy efficacy.
Barinova
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D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism / Q000502:physiology; D003000:Clonidine / Q000494:pharmacology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis / Q000378:metabolism; D017719:Diabetic Foot / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D018341:Receptors, Adrenergic, alpha-2 / Q000096:biosynthesis*; D012720:Severity of Illness Index; D014945:Wound Healing / Q000502:physiology*
D000316:Adrenergic alpha-Agonists; D018341:Receptors, Adrenergic, alpha-2; D003000:Clonidine