Acylated pregnane glycosides from Caralluma tuberculata and their antiparasitic activity.
Five pregnane glycosides were isolated from Caralluma tuberculata (1-5), in addition to a known one (russelioside E, 6). The structures of the isolated compounds were elucidated by the analysis of NMR data and FAB-MS experiments. All the isolated compounds were tested for their antimalarial and antitrypanosomal activities as well as their cytotoxicity against human diploid embryonic cell line (MRC5).
Abdel-Sattar
Essam
E
Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. abdelsattar@yahoo.com
Harraz
Fathalla M
FM
Al-ansari
Soliman Mohammed Abdullah
SM
El-Mekkawy
Sahar
S
Ichino
Chikara
C
Kiyohara
Hiroaki
H
Ishiyama
Aki
A
Otoguro
Kazuhiko
K
Omura
Satoshi
S
Yamada
Haruki
H
D000215:Acylation; D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry* / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D011278:Pregnanes / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000977:Antiparasitic Agents; D006027:Glycosides; D011278:Pregnanes