title: An approach to managing non-melanoma skin cancer of the nose with mucosal invasion: our experience.
abstract: CONCLUSIONS
  The absence of recurrences after final nasal reconstruction demonstrates the reliability of our three-stage strategy and the necessity to delay nasal reconstruction, focusing attention on oncological safety for nasal non-melanoma skin cancer (NMSC) with mucosal invasion.
  
  
  OBJECTIVE
  To validate a therapeutic strategy aimed at oncological safety and minimization of possible recurrences after full-thickness excision of nasal NMSC with mucosal invasion. The strategy was divided into three stages: surgical excision with clinically safe perilesional skin margins and extemporary frozen section histological control; 8-15 months follow-up leaving the nasal defect unreconstructed with a 'wait and see' strategy; new extemporary histological control of defect margins and, if negative, definitive reconstruction.
  
  
  METHODS
  Twenty patients affected by nasal NMSC with mucosal invasion were treated and followed up.
  
  
  RESULTS
  Basal cell carcinoma was the most common lesion (75%), followed by squamous cell carcinoma (25%). Ultrasonography excluded lymphatic involvement for SCC. Before final reconstruction, extemporary histological examination revealed the presence of tumour cells in three patients. After tumour extirpation, these patients were resubmitted to a new follow-up period before reconstruction. No recurrences were observed after definitive nasal reconstruction in all patients during the 5-year follow-up.
authors.affiliation: Department of Plastic and Reconstructive Surgery, University La Sapienza, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Chiummariello
authors.forename: L A
authors.initials: LA
authors.lastname: Dessy
authors.forename: E M
authors.initials: EM
authors.lastname: Buccheri
authors.forename: D N
authors.initials: DN
authors.lastname: Gagliardi
authors.forename: G
authors.initials: G
authors.lastname: Menichini
authors.forename: C
authors.initials: C
authors.lastname: Alfano
authors.forename: N
authors.initials: N
authors.lastname: Scuderi
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa; D009361:Neoplasm Invasiveness; D009669:Nose Neoplasms / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D012225:Rhinoplasty / Q000379:methods*; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome