title: In silico study of a novel gene evolved from an ancestral SVIP gene and highly expressed in the adult mouse testes.
abstract: We found that a cDNA clone isolated from a mouse testis cDNA library, 1700015G11 (Mmu_15G11), corresponded to the most highly expressed testis-specific mRNA in the adult mouse. Although the Mmu_15G11 cDNA is predicted to encode a small protein consisting of 67 amino acid residues, it has not yet been functionally annotated and has been designated as an unclassifiable clone. Since the Mmu_15G11 protein possibly has a pivotal role in spermatogenesis, we initiated an in silico study of this clone, and revealed that an ancestral gene of 15G11 genes evolved from an ancestral gene for mammalian small valosin-containing protein-interacting protein (SVIP) genes by gene duplication. Although SVIP protein reportedly participates in endoplasmic reticulum-related protein degradation, 15G11 protein is predicted to be a nuclear protein and possibly participates in the interaction between proteins and nuclear DNA.
authors.affiliation: Hirakata Ryoikuen, 2-1-1 Tsudahigashi, Hirakata, Osaka, Japan.
authors.forename: Momoko
authors.initials: M
authors.lastname: Yoshida
authors.forename: Akifumi
authors.initials: A
authors.lastname: Yamashita
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Idoji
authors.forename: Seiji
authors.initials: S
authors.lastname: Nishiguchi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Shimada
authors.forename: Teruo
authors.initials: T
authors.lastname: Yasunaga
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Yamanishi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030561:Databases, Nucleic Acid; D019143:Evolution, Molecular; D015870:Gene Expression; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D010802:Phylogeny; D013737:Testis / Q000166:cytology / Q000502:physiology*
chemical_list: D009687:Nuclear Proteins