[Assesment of real optoelectronic method in the detection of cervical intraepithelial neoplasia].
BACKGROUND
Biophysics is becoming an important factor in prevention of cervical cancer. One of the most promising concepts of biophysical program for the prevention of cervical cancer is the optoelectronic method--Truscreen.


OBJECTIVE
The objective of the work was to determine the usefulness of the real optoelectronic device in the detection of cervical intraepithelial neoplasia


METHODS
From August 2006 till September 2007, 147 patients were examined in the Laboratory of Pathophysiology of Uterine Cervix in Gynecology and Obstetrics Clinical Hospital of Karol Marcinkowski University of Medical Sciences. The study reports prospective, blind trial. The following diagnostic examinations were carried out: examination with the use of optoelectronic method, DNA HPV HIGH RISK test, colposcopy examination and histopatologic biopsy.


RESULTS
The specificity of the optoelectronic method for positive diagnoses amounted to 84%. The sensitivity for intraephitelial changes (CIN 1, CIN 2) was estimated at 53%, and for severe grades (CIN 3, Carcinoma planoepitheliale) at 80%.


CONCLUSIONS
Optoelectronic diagnostics is useful in the detection of cervical neoplastic changes. The optoelectronic method may prove to be a significant diagnostic device at the basic and advanced level of cervical screening. The advantage of the optoelectronic method over prevention based on cytodiagnostics and colposcopy, includes the immediate result of the examination and its automation as well as standardization.
Pruski
Dominik
D
Klinika Onkologii Ginekologicznej, Katedra Ginekologii, Połoznictwa i Onkologii Ginekologicznej UM im. K. Marcinkowskiego w Poznaniu. pruski@oxytop.pl
Kedzia
Witold
W
Przybylski
Marcin
M
Józefiak
Agata
A
Kedzia
Helena
H
Spaczyński
Marek
M
D000328:Adult; D002584:Cervix Uteri / Q000473:pathology*; D003127:Colposcopy; D004279:DNA, Viral / Q000032:analysis*; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008875:Middle Aged; D055095:Optics and Photonics; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000473:pathology; D011044:Poland; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D014626:Vaginal Smears / Q000295:instrumentation* / Q000379:methods*; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000473:pathology
D004279:DNA, Viral