title: [Clinical feature of Fitz-Hugh-Curtis syndrome: analysis of 25 cases].
abstract: OBJECTIVE
  Fitz-Hugh-Curtis syndrome is defined as perihepatitis associated with pelvic inflammatory disease (PID). We retrospectively analyzed clinical and laboratory manifestations as well as the therapeutic response in patients with clinically diagnosed Fitz-Hugh-Curtis syndrome.
  
  
  METHODS
  A cohort of 25 patients with PID and perihepatitis (as diagnosed by dynamic abdominal computed tomography (CT)) was enrolled. The prognosis, clinical manifestations, and physical examination, laboratory, and CT findings were analyzed.
  
  
  RESULTS
  The mean (+/-SD) age of the patients was 32(+/-8) years, and all of them were sexually active, premenopausal women, and presented with abdominal pain. Of these, 52% complained of vaginal discharge. On physical examination, right upper-quadrant tenderness was the most common finding (84%), with lower-abdominal tenderness being present in 20% of patients. On laboratory examination, erythrocyte sedimentation rate and C-reactive protein were increased in 76% and 92% of the patients, respectively. The white blood cell count was increased in 60% of them. Most patients had a normal liver function test. Using a specimen of the cervical discharge, the polymerase chain reaction to test for Chlamydia trachomatis were positive in 87% (13/15) of the patients, and Chlamydia antigen was found in 75% (9/12) of them. Dynamic abdominal CT revealed subcapsular enhancement of the liver in the arterial phase. All of the patients improved with antibiotic therapy.
  
  
  CONCLUSIONS
  Symptoms and physical findings suggestive of PID are not present in many patients with Fitz-Hugh-Curtis syndrome. When a premenopausal woman complains of upper abdominal pain and shows CT findings compatible with perihepatitis, examination of cervical discharge would be recommended to assess the possibility of Fitz-Hugh-Curtis syndrome.
authors.affiliation: Department of Internal Medicine, Eulji University College of Medicine, Eulji University Hospital, Daejeon, Korea.
authors.forename: Hyeon Woong
authors.initials: HW
authors.lastname: Yang
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Jung
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Han
authors.forename: Anna
authors.initials: A
authors.lastname: Kim
authors.forename: Yun Jung
authors.initials: YJ
authors.lastname: Lee
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Cha
authors.forename: Hun
authors.initials: H
authors.lastname: Go
authors.forename: Gi Young
authors.initials: GY
authors.lastname: Choi
authors.forename: Soung Hoon
authors.initials: SH
authors.lastname: Cho
authors.forename: Sin Hyung
authors.initials: SH
authors.lastname: Lim
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002690:Chlamydia Infections / Q000175:diagnosis / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D015331:Cohort Studies; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D006069:Gonorrhea / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006505:Hepatitis / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D000292:Pelvic Inflammatory Disease / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D013577:Syndrome; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents