ROS eliminate danger.
Necrotic cells release HMGB1 as a danger signal to activate the immune system. In this issue of Immunity, Kazama et al. (2008) identify a mechanism that determines whether HMGB1 is tolerogenic or immunogenic.
Peter
Marcus E
ME
The Ben May Department of Cancer Research, The University of Chicago, Chicago, IL 60637, USA. mpeter@uchicago.edu
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D024243:HMGB1 Protein / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D009336:Necrosis / Q000276:immunology; D017382:Reactive Oxygen Species / Q000276:immunology*
D024243:HMGB1 Protein; D017382:Reactive Oxygen Species