The molecule role ontology: an ontology for annotation of signal transduction pathway molecules in the scientific literature.
In general, it is not easy to specify a single sequence identity for each molecule name that appears in a pathway in the scientific literature. A molecule name may stand for concepts of various granularities, from concrete objects such as H-Ras and ERK1 to abstract concepts or categories such as Ras and MAPK. Typically, the relations among molecule names derive a hierarchical structure; without a proper way to handle this knowledge, it becomes ever more difficult to develop a reliable pathway database. This paper describes an ontology that is designed to annotate molecules in the scientific literature on signal transduction pathways.
Yamamoto
Satoko
S
Institute for Bioinformatics Research and Development, Japan Science and Technology Agency, Tokyo, Japan.
Asanuma
Takao
T
Takagi
Toshihisa
T
Fukuda
Ken Ichiro
KI