Clear cell change in colonic polyps.
In this study, the pathogenesis of clear cell change in colorectal epithelial lesions was studied. A total of 4 cases of clear cell change (1 hyperplasic polyp and 3 adenomas) were characterized using histochemistry, immunohistochemistry, and electron microscopy. All lesions developed in the left colon. In all, 1 adenoma with clear cell dysplastic glands progressed to adenocarcinoma without clear cell change. Clear cell cytoplasmatic vacuoles were negative for glycogen and mucins (MUC 2, MUC 5AC). Ki-67 LI in clear cell adenoma components was lower than in common adenoma components of the same dysplasia grades (while p53 and beta-catenin were similarly expressed). Ultrastructural features of clear cell change showed features of lipid-like material. Clear cell change is found in hyperplastic and neoplastic lesions of the colon and is not due to the accumulation of glycogen or mucins. A degenerative nature of clear cell change is suggested by the demonstration of lipid-like material in the vacuoles of clear cells.
Eloy
Catarina
C
Department of Pathology, Hospital de S. João, Institute of Molecular Pathology and Immunology of the University of Porto, Portugal.
Lopes
José M
JM
Faria
Gil
G
Moreira
Herculano
H
Brandão
Abílio
A
Silva
Teresa
T
Carneiro
Fátima
F
D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000236:Adenoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002452:Cell Count; D002467:Cell Nucleus / Q000648:ultrastructure; D003106:Colon / Q000378:metabolism / Q000473:pathology*; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003593:Cytoplasm / Q000648:ultrastructure; D006801:Humans; D006965:Hyperplasia; D007124:Immunoenzyme Techniques; D066298:In Vitro Techniques; D007417:Intestinal Polyps / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen