title: The role of alphoid higher order repeats (HORs) in the centromere folding.
abstract: Understanding the folding of centromere DNA in the maximally condensed methaphase chromosome remains a basic challenge in cell biology. We propose here a set of structural models with a graphical presentation of alphoid higher order repeat (HOR) distribution in the centromere folding, based on the assumption of encryption key for microtubule-centromere interaction which arises from chromosome-specific crystal-like structure of HORs. Specific HOR leads to a characteristic geometrical pattern which may be responsible for individual microtubule to recognize a specific structure of centromere in each chromosome.
authors.affiliation: Department of Internal Medicine, University Hospital Rebro, University of Zagreb, Kispatićeva 12, 10000 Zagreb, Croatia. rosandic@hazu.hr
authors.forename: Marija
authors.initials: M
authors.lastname: Rosandić
authors.forename: Matko
authors.initials: M
authors.lastname: Gluncić
authors.forename: Vladimir
authors.initials: V
authors.lastname: Paar
authors.forename: Ivan
authors.initials: I
authors.lastname: Basar
mesh_terms: D000465:Algorithms; D001483:Base Sequence; D002503:Centromere / Q000235:genetics*; D019295:Computational Biology; D003198:Computer Simulation; D004247:DNA / Q000235:genetics*; D006801:Humans; D008870:Microtubules / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D016415:Sequence Alignment
chemical_list: D004247:DNA