[Metalloproteinases. Structure and function].
Matrix metalloproteinases (MMPs) belong to a large family of multidomain zinc endopeptidases. They are one of the most important proteolitic enzymes which digest components of the extracellular matrix and abundant macromolecules on cell surface and take part in many physiological processes, such as apoptosis or angiogenesis. MMPs are also engaged in the pathogenesis of many diseases such as arthritis and cancer. The development of effective inhibitors and discovery of their mechanisms of action can have significant influence on therapeutic strategy.
Lipka
Dominik
D
Instytut Immunologii i Terapii Doświadczalnej Polskiej Akademii Nauk im. Ludwika Hirszfelda, Wrocław.
Boratyński
Janusz
J
D010129:4-Aminobenzoic Acid / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001168:Arthritis / Q000188:drug therapy / Q000201:enzymology; D001327:Autoimmune Diseases / Q000201:enzymology; D002465:Cell Movement / Q000502:physiology; D002738:Chloroquine / Q000378:metabolism; D004338:Drug Combinations; D004789:Enzyme Activation; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology; D018919:Neovascularization, Physiologic / Q000502:physiology; D010205:Pantothenic Acid / Q000378:metabolism; D011736:Pyridoxine / Q000378:metabolism; D011796:Quinacrine / Q000378:metabolism; D019714:Tissue Inhibitor of Metalloproteinases / Q000737:chemistry / Q000378:metabolism
D004338:Drug Combinations; D061965:Matrix Metalloproteinase Inhibitors; D008565:Membrane Proteins; D019714:Tissue Inhibitor of Metalloproteinases; C050914:aminobenzoic acid, calcium pantothenate, chloroquine, quinacrine, pyridoxine drug combination; D010205:Pantothenic Acid; D002738:Chloroquine; D020782:Matrix Metalloproteinases; D011796:Quinacrine; D011736:Pyridoxine; D010129:4-Aminobenzoic Acid