[Association of the chromosomal region 2q35 with type 1 diabetes mellitus in the Russian patients from Moscow].
To map human chromosome 2 region associated with type 1 diabetes mellitus, 89 families with concordant and discordant sib pairs were analyzed. Linkage and association with type 1 diabetes were examined using polymorphic microsatellite markers spanning the region of about 4 Mb. The linkage plot was constructed, and association of the five microsatellite markers within the chromosomal region 2q35 was examined. Polymorphic marker D2S137 (Z' = 3.225, p(c) = 0.0048) demonstrated maximum linkage and association with type 1 diabetes.
Chernysheva
A
A
Tsitlidze
N M
NM
Savost'ianov
K V
KV
Zil'berman
L I
LI
Kuraeva
T L
TL
Peterkova
V A
VA
Dedov
I I
II
Nosikov
V V
VV
D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005190:Family; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D009031:Moscow; D011110:Polymorphism, Genetic