Predicting delayed graft function and mortality in kidney transplantation.
Kidney transplantation (KT) is the treatment of choice for end-stage renal failure, but such patients are increasingly older and have additional comorbid conditions leading to high mortality rates after transplantation. Delayed graft function is a common complication after KT, especially in recipients who receive expanded criteria donor, and these complications are associated with a poorer graft survival in the long term. Taken together, an appropriate assessment of comorbidity grouped in prognostic indexes could be a useful tool to make crucial therapeutic decisions at the time of transplant. Allocation systems based upon a recipient risk score, as well as identification of risk factors for delayed graft function, may improve outcomes after KT. The aim of this review is to assess the contribution and utility of comorbid conditions, grouped in prognostic indexes to predict and improve kidney transplant outcomes.
Hernández
Domingo
D
Department of Nephrology, Hospital Universitario de Canarias, Ofra s/n, 38320 La Laguna, Tenerife, Spain. domingohernandez@gmail.com
Rufino
Margarita
M
González-Posada
José Manuel
JM
Estupiñán
Sara
S
Pérez
Germán
G
Marrero-Miranda
Domingo
D
Torres
Armando
A
Pascual
Julio
J
D015897:Comorbidity; D005544:Forecasting; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000401:mortality*; D013997:Time Factors; D016896:Treatment Outcome