Bone alterations during HIV infection.
Osteopenia and osteoporosis are common in HIV-1-infected individuals and represent a challenge in clinical and therapeutic management. Since the mechanisms underlying this degenerative process are largely unsettled and it has not yet been determined whether bone dysfunction is linked to HIV-1-mediated direct and/or indirect effects on osteoblasts/osteoclasts cross-talk regulation, this brief review analyzes an array of mechanisms that could account for the dramatic bone derangement (bone loss and osteopenia/osteoporosis) during the course of HIV-1 infection.
De Crignis
Elisa
E
Department of Clinical and Experimental Medicine, University of Bologna, Bologna, Italy. elisa.decrignis@gmail.com
Cimatti
Laura
L
Borderi
Marco
M
Gibellini
Davide
D
Re
Maria Carla
MC
D000328:Adult; D001851:Bone Diseases, Metabolic / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000453:epidemiology / Q000209:etiology*