Comment on "Genetically determined differences in learning from errors".
Klein et al. (Reports, 7 December 2007, p. 1642) used individuals with a polymorphism adjacent to the dopamine receptor 2 gene as naturally occurring models for reduced brain dopamine receptor density in a probabilistic learning task. We raise the concern that this polymorphism resides in the gene for the kinase ANKK1, where it causes a nonconservative amino acid exchange.
Lucht
Michael
M
Hospital for Psychiatry and Psychotherapy, Haus 30, Ernst-Moritz-Arndt University, Greifswald, Stralsund 18437, Germany. lucht@uni-greifswald.de
Rosskopf
Dieter
D
D000483:Alleles; D001921:Brain / Q000378:metabolism; D003001:Cloning, Molecular; D006801:Humans; D007858:Learning; D011110:Polymorphism, Genetic; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000502:physiology; D011506:Proteins / Q000235:genetics / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
D011506:Proteins; D017448:Receptors, Dopamine D2; C487552:TTC12 protein, human; C489948:ANKK1 protein, human; D017346:Protein Serine-Threonine Kinases