title: Identification and analysis of novel tandem repeats in the cell surface proteins of archaeal and bacterial genomes using computational tools.
abstract: We have identified four novel repeats and two domains in cell surface proteins encoded by the Methanosarcina acetivorans genome and in some archaeal and bacterial genomes. The repeats correspond to a certain number of amino acid residues present in tandem in a protein sequence and each repeat is characterized by conserved sequence motifs. These correspond to: (a) a 42 amino acid (aa) residue RIVW repeat; (b) a 45 aa residue LGxL repeat; (c) a 42 aa residue LVIVD repeat; and (d) a 54 aa residue LGFP repeat. The domains correspond to a certain number of aa residues in a protein sequence that do not comprise internal repeats. These correspond to: (a) a 200 aa residue DNRLRE domain; and (b) a 70 aa residue PEGA domain. We discuss the occurrence of these repeats and domains in the different proteins and genomes analysed in this work.
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad 500 046, India.
authors.forename: S
authors.initials: S
authors.lastname: Adindla
authors.forename: K K
authors.initials: KK
authors.lastname: Inampudi
authors.forename: K
authors.initials: K
authors.lastname: Guruprasad
authors.forename: L
authors.initials: L
authors.lastname: Guruprasad