title: [Oxidative damages of long-term exposure to low level fullerenes (C60) in Carassius auratus].
abstract: To determine the potential effects of fullerenes (C60) on aquatic organism, larval Carassius auratus was exposed to low level C60 (0.04-1.0 mg x L(-1)) for 32 days. Then the oxidative damages in brain, liver and gill tissue of larval Carassius auratus were measured. The results showed that: compared to the control, the reduced glutathione (GSH) contents in all different tissues decreased significantly (p < 0.05), and the most serious inhibition of GSH with a 14.3% inhibition rate was found in the gill tissue of larval crucian exposed to 1 mg x L(-1) C60 aqueous suspension; whereas the superoxide dismutase (SOD) and catalase (CAT) activities in liver tissue, Na+ -K+ -ATPase activities in gill tissue were stimulated significantly (p < 0.05), and the maximal activity of them were 121.34% (exposed to 0.04 mg x L(-1) C60 aqueous suspension), 114.80% (exposed to 0.04 mg x L(-1) C60 aqueous suspension) and 348.59% (exposed to 0.20 mg x L(-1) C60 aqueous suspension) respectively than that of control. The experiment results indicated that oxidative damages induced by long-term exposure might play a role in the bio-toxicity of C60 to larval crucian.
authors.affiliation: College of Environmental Science & Engineering, Nankai University, Tianjin 300071, China. zxsgx1977@gmail.com
authors.forename: Xiao-shan
authors.initials: XS
authors.lastname: Zhu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.forename: Yu-peng
authors.initials: YP
authors.lastname: Lang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Zheng-hua
authors.initials: ZH
authors.lastname: Duan
authors.forename: Kun
authors.initials: K
authors.lastname: Yao
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D004781:Environmental Exposure; D037741:Fullerenes / Q000633:toxicity*; D005880:Gills / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006054:Goldfish / Q000378:metabolism*; D007814:Larva / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D037741:Fullerenes; D014874:Water Pollutants, Chemical; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D005978:Glutathione