title: Recurrent choroidal neovascularization after macular translocation surgery with 360-degree peripheral retinectomy.
abstract: OBJECTIVE
  To evaluate the pattern of age-related macular degeneration in the new foveal location after macular translocation surgery with 360 degree peripheral retinectomy for neovascular age-related macular degeneration.
  
  
  METHODS
  Clinical data, fundus photos, and fluorescein angiograms of patients in the Duke Macular Translocation Study were reviewed with 2-year follow-up data.
  
  
  RESULTS
  With 56 patients completing follow-up, no patient developed de novo choroidal neovascularization (CNV), geographic atrophy, or drusen in the new subfoveal retinal pigment epithelium bed. By 2 years, 14 patients (25%) developed recurrent CNV and 13 of these 14 recurrences clearly arose from the old CNV bed. Of the 13 recurrences clearly arising from the old bed, 12 of them had recurrent CNV that involved the margin of the bed closest to the repositioned fovea. Smokers were 5.3 times (95% confidence interval: 1.2-24) more likely to develop recurrent CNV over 2 years. Despite treatment, median visual acuity for the 14 eyes with recurrent CNV was 20/200 compared with 20/80 in eyes without recurrence.
  
  
  CONCLUSIONS
  Findings in this study support the hypotheses that the development of CNV occurs via a signaling mechanism from the fovea.
authors.affiliation: Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA. cab8b@yahoo.com
authors.forename: Claxton A
authors.initials: CA
authors.lastname: Baer
authors.forename: Catherine Bowes
authors.initials: CB
authors.lastname: Rickman
authors.forename: Sunil
authors.initials: S
authors.lastname: Srivastava
authors.forename: Goldis
authors.initials: G
authors.lastname: Malek
authors.forename: Sandra
authors.initials: S
authors.lastname: Stinnett
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Toth
mesh_terms: D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000209:etiology*; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005584:Fovea Centralis; D006801:Humans; D008266:Macula Lutea / Q000637:transplantation*; D008268:Macular Degeneration / Q000150:complications* / Q000601:surgery*; D013508:Ophthalmologic Surgical Procedures / Q000009:adverse effects; D011446:Prospective Studies; D012008:Recurrence; D012160:Retina / Q000601:surgery*; D055213:Retinal Pigment Epithelium / Q000473:pathology; D016042:Transplantation, Heterotopic