Plasma Epstein-Barr viral load predicting response after chemotherapy for post-transplant lymphoproliferative disease.
Transplant patients are particularly at risk of developing B post-transplant lymphoproliferative disease (PTLD) related to intensive immunosuppressive treatment to prevent graft rejection. In EBV-positive PTLDs, EBV-DNA can be found in the patients' peripheral blood. Several methods have been described to assess peripheral blood EBV viral load. We report a case of a 13-year-old child who developed EBV-positive PTLD after renal transplantation. We assessed EBV plasma viral load by quantitative PCR and we found that the clearance of EBV-DNA correlated well with response to treatment.
Machado
Alex Sandro C
AS
Serviço de Hematologia, Hospital do Câncer I, Instituto Nacional do Câncer, Praça Cruz Vermelha, 20 230-130, Rio de Janeiro, Brazil.
Apa
Alexandre Gustavo
AG
Magalhães de Rezende
Lidia Maria
LM
Amoêdo
Nívea Dias
ND
Rumjanek
Franklin David
FD
Bacchi
Carlos E
CE
Klumb
Claudete Esteves
CE
D000293:Adolescent; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000188:drug therapy* / Q000209:etiology; D019562:Viral Load
D004279:DNA, Viral