Role of retinoic receptors in lung carcinogenesis.
Several in vitro and in vivo studies have examined the positive and negative effects of retinoids (vitamin A analogs) in premalignant and malignant lesions. Retinoids have been used as chemopreventive and anticancer agents because of their pleiotropic regulator function in cell differentiation, growth, proliferation and apoptosis through interaction with two types of nuclear receptors: retinoic acid receptors and retinoid X receptors. Recent investigations have gradually elucidated the function of retinoids and their signaling pathways and may explain the failure of earlier chemopreventive studies. In this review we have compiled basic and recent knowledge regarding the role of retinoid receptors in lung carcinogenesis. Sensitive and appropriate biological tools are necessary for screening the risk population and monitoring the efficacy of chemoprevention. Investigation of retinoid receptors is important and may contribute to the establishment of new strategies in chemoprevention for high-risk patients and in the treatment of lung cancer.
Bogos
Krisztina
K
Tumor Biology, Budapest, Hungary. bogosa@freemail.hu
Renyi-Vamos
Ferenc
F
Kovacs
Gabor
G
Tovari
Jozsef
J
Dome
Balazs
B
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D044127:Epigenesis, Genetic; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D018168:Receptors, Retinoic Acid / Q000502:physiology*; D012176:Retinoids / Q000627:therapeutic use; D015398:Signal Transduction
D000970:Antineoplastic Agents; D018168:Receptors, Retinoic Acid; D012176:Retinoids