title: Environmental tobacco smoke (ETS) evaluation of a third-generation electrically heated cigarette smoking system (EHCSS).
abstract: This sub-study of a randomized, controlled, forced-switching, open-label, parallel-group, clinical study compared environmental tobacco smoke (ETS) produced when 60 male and female adult smokers switched to a third-generation electrically heated cigarette smoking system (EHCSS), continued to smoke a conventional cigarette (CC), or stopped smoking (No-smoking). Concentrations of air constituents including respirable suspended particulate (RSP), carbon monoxide (CO), ammonia and total volatile organic compounds (TVOCs) and ETS markers including solanesol-related particulate matter (Sol-PM), ultraviolet absorbing particulate matter (UVPM), fluorescent particulate matter (FPM), nicotine and 3-ethenyl pyridine (3-EP) were measured in a ventilated, furnished conference room over a 2-h period on separate occasions for each smoking condition. When the EHCSS was used, concentrations of CO and most ETS markers were in the same range as during no-smoking. Concentrations of ammonia were reduced by 41% and concentrations of other selected constituents of ETS were reduced by 87-99% in the air of a room in which EHCSS cigarettes were smoked as compared to concentrations in the same room when conventional cigarettes were smoked. Switching from conventional cigarette smoking to the EHCSS resulted in substantial reductions in concentrations of several markers of environmental tobacco smoke.
authors.affiliation: Philip Morris USA, Research Center, Clinical Evaluation, 4201 Commerce Road, Richmond, VA 23234, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Frost-Pineda
authors.forename: Barbara K
authors.initials: BK
authors.lastname: Zedler
authors.forename: Qiwei
authors.initials: Q
authors.lastname: Liang
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Roethig
mesh_terms: D000641:Ammonia / Q000737:chemistry; D002248:Carbon Monoxide / Q000737:chemistry; D004560:Electricity; D005260:Female; D005453:Fluorescence; D006801:Humans; D008297:Male; D009538:Nicotine / Q000737:chemistry; D052638:Particulate Matter / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D012907:Smoking / Q000378:metabolism*; D013729:Terpenes / Q000737:chemistry; D013997:Time Factors; D014028:Tobacco Smoke Pollution / Q000032:analysis*; D014466:Ultraviolet Rays; D014753:Vinyl Compounds / Q000737:chemistry; D055549:Volatile Organic Compounds / Q000737:chemistry
chemical_list: D052638:Particulate Matter; D011725:Pyridines; D013729:Terpenes; D014028:Tobacco Smoke Pollution; D014753:Vinyl Compounds; D055549:Volatile Organic Compounds; D009538:Nicotine; D000641:Ammonia; D002248:Carbon Monoxide; C017719:solanesol; C076387:3-vinylpyridine