title: The CCR5 (-2135C/T) polymorphism may be associated with the development of Kawasaki disease in Korean children.
abstract: BACKGROUND
  Kawasaki disease (KD) is an acute vasculitis syndrome of unknown etiology that frequently affects small to medium size arteries. C-C chemokine receptor 5 (CCR5) is a chemokine receptor that binds C-C chemokines. This study investigated the association of the CCR5 (-2135C/T) polymorphism with KD in Korean children.
  
  
  METHODS
  The study population consisted 189 Korean children with KD and 194 Korean children with congenital heart disease (CHD). CCR5 (-2135C/T) polymorphism genotypes were determined using the single-base extension method.
  
  
  RESULTS
  The allele frequencies of the CCR5 (-2135C/T) polymorphism differed significantly between CHD children and KD children (-2135T/T, 16.75% vs. 30.05%, aOR 2.14, 95% CI 1.31-3.51). The tested laboratory parameters differed significantly between the KD and CHD groups. The development of coronary artery aneurysm in KD patients was not associated with the CCR5 polymorphism.
  
  
  CONCLUSIONS
  Our findings suggest that the T allele at the CCR5 (-2135C/T) polymorphism might be associated with the development of KD in Korean children but does not appear to be associated with the development of coronary artery aneurysm.
authors.affiliation: Department of Pediatrics, Asan Medical Center, College of Medicine, Ulsan University, Seoul, South Korea.
authors.forename: Won Kyoung
authors.initials: WK
authors.lastname: Jhang
authors.forename: Mi-Jin
authors.initials: MJ
authors.lastname: Kang
authors.forename: Hyun-Seung
authors.initials: HS
authors.lastname: Jin
authors.forename: Jinho
authors.initials: J
authors.lastname: Yu
authors.forename: Byoung-ju
authors.initials: BJ
authors.lastname: Kim
authors.forename: Bong Seong
authors.initials: BS
authors.lastname: Kim
authors.forename: Jong-Keuk
authors.initials: JK
authors.lastname: Lee
authors.forename: Eul-Ju
authors.initials: EJ
authors.lastname: Seo
authors.forename: Han-Wook
authors.initials: HW
authors.lastname: Yoo
authors.forename: In Sook
authors.initials: IS
authors.lastname: Park
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Hong
authors.forename: Soo-Jong
authors.initials: SJ
authors.lastname: Hong
mesh_terms: D000483:Alleles; D002648:Child; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D007723:Korea / Q000453:epidemiology; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D019713:Receptors, CCR5 / Q000235:genetics*
chemical_list: D019713:Receptors, CCR5