Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines.
Reaction of 6a-f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a-f in excellent yield. The newly synthesized heterocycles were characterized by IR, (1)H NMR, and mass spectral data. Compounds 7a-f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.
Venu
T D
TD
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, Karnataka 570 006, India.
Khanum
S A
SA
Firdouse
Aiysha
A
Manuprasad
B K
BK
Shashikanth
Sheena
S
Mohamed
Riyaz
R
Vishwanth
Bannikuppe Sannanaik
BS
D000465:Algorithms; D000818:Animals; D017849:Animals, Inbred Strains; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D005528:Foot / Q000473:pathology; D051379:Mice; D054467:Phospholipases A2 / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D014456:Ulcer / Q000209:etiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011743:Pyrimidines; D011451:Prostaglandin-Endoperoxide Synthases; D054467:Phospholipases A2