title: Recognizing and effectively treating depression.
abstract: In 2004, more people died in Europe from suicide than from road accidents. The lifetime prevalence of major depression is 20% for women and 10% for men. Depression is a leading cause of disability and decreased quality of life. In spite of this, numerous studies have shown that only approximately 50% of depressed patients are recognized as such in primary care. In a recent international survey of everyday management of depression we observed that only approximately 15% of patients became symptom-free following treatment. In spite of this low level of remission primary care physicians and psychiatrist only rarely increased the dose of antidepressant or switched to another medication as unanimously recommended by different guidelines. Numerous studies have demonstrated the importance of maintaining treatment for >6 months after remission is obtained in order to prevent relapse and recurrence. However, a recent study reported that only 19% of a cohort of patients in primary care continued treatment for 6 months as recommended. Antidepressants can be very effective but only when used correctly at adequate doses and for a sufficient duration. Although new improved antidepressants are obviously desirable, a greater recognition of depression and its treatment by the correct use of currently available antidepressant drugs could greatly improve the management of this major public health problem.
authors.affiliation: French National Institute of Health and Medical Research, Hôpital Pitié Salpêtrière, Paris, France. lecru@ext.jussieu.fr
authors.forename: Yves
authors.initials: Y
authors.lastname: Lecrubier
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000150:complications / Q000188:drug therapy / Q000523:psychology; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D017408:Guidelines as Topic; D006801:Humans; D011320:Primary Health Care
chemical_list: D000928:Antidepressive Agents