The impact of colony-stimulating factor-1 on fracture healing: an experimental study.
The role of colony stimulating factor-1 (CSF-1) in the regulation of osteoclasts and bone remodeling suggests that CSF-1 may also be involved in regulation of bone healing. The ability of CSF-1 to promote healing of bone defects was tested in a rabbit model. Twenty-four New Zeeland rabbits were included in the study. Animals were assigned to two groups: the control group (n = 12) was treated by plate fixation. The animals in the second group (n = 12) were also stabilized by conventional plating and received additionally CSF-1 for 2 weeks systemically. Histologic, histomorphometric, and radiologic examinations were performed to evaluate the healing process at 4, 8, and 12 weeks following surgery. Animals that were treated by CSF-1 produced a significantly higher amount of mineralized bone over the first 8 weeks after fracture compared to the control animals. Furthermore, a higher number of osteoclasts was found in CSF-1-treated animals within the first 8 weeks, compared to the controls. The present data emphasize for the first time the importance of CSF-1 in the bone healing. The use of CSF-1 in addition to conventional fixation might be a novel approach for the treatment of bone defects.
Sarahrudi
Kambiz
K
Department of Traumatology, Medical University of Vienna, Vienna, Austria.
Mousavi
Mehdi
M
Grossschmidt
Karl
K
Sela
Nezir
N
König
Franz
F
Vécsei
Vilmos
V
Aharinejad
Seyedhossein
S
D000818:Animals; D001696:Biomechanical Phenomena; D001861:Bone Regeneration / Q000187:drug effects; D016723:Bone Remodeling; D001842:Bone and Bones / Q000473:pathology; D005260:Female; D005264:Femoral Fractures / Q000473:pathology / Q000628:therapy*; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology; D017102:Fracture Healing; D016173:Macrophage Colony-Stimulating Factor / Q000378:metabolism* / Q000627:therapeutic use; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D010010:Osteoclasts / Q000166:cytology / Q000378:metabolism; D010027:Osteotomy; D011817:Rabbits; D011859:Radiography; D013997:Time Factors
D016173:Macrophage Colony-Stimulating Factor