title: Comparison of radiotherapy strategies for locally advanced hypopharyngeal cancer after resection and ileocolic flap reconstruction.
abstract: CONCLUSIONS
  IMRT provided better conformity, less toxicity and better function restoration for advanced hypopharyngeal carcinoma after major surgery with ileocolic flap reconstruction.
  
  
  OBJECTIVE
  To compare the results of adjuvant conventional radiotherapy (2DRT) with intensity modulated radiation therapy (IMRT) for locally advanced hypopharyngeal cancer after resection and ileocolic free flap reconstruction and to design treatment plans for those two modalities plus 3D conformal radiotherapy (3DCRT) for dose distribution comparison.
  
  
  METHODS
  13 locally advanced hypopharyngeal cancer patients were enrolled, 8 treated with 2DRT and 5 with IMRT. Different plans were planned for 3 IMRT-treated patients for comparing dose distribution.
  
  
  RESULTS
  After major surgery, patients treated with IMRT had less toxicity and better functional restoration than those with 2DRT. IMRT and 3DCRT both showed lower dose to the spinal cord than did 2DRT. Only IMRT showed reduced dose to ileocolic flap.
authors.affiliation: Department of Radiation Oncology, Mackay Memorial Hospital, 92 Chung San North Road Section 2, Taipei 104,Taiwan.
authors.forename: Hung-Chi
authors.initials: HC
authors.lastname: Tai
authors.forename: Chen-Hsi
authors.initials: CH
authors.lastname: Hsieh
authors.forename: K S Clifford
authors.initials: KS
authors.lastname: Chao
authors.forename: Shih-Hua
authors.initials: SH
authors.lastname: Liu
authors.forename: Yi-Shing
authors.initials: YS
authors.lastname: Leu
authors.forename: Yih-Fang
authors.initials: YF
authors.lastname: Chang
authors.forename: Hung-Tao
authors.initials: HT
authors.lastname: Hsiao
authors.forename: Yuan-Ching
authors.initials: YC
authors.lastname: Chang
authors.forename: David Yc
authors.initials: DY
authors.lastname: Huang
authors.forename: Yu-Jen
authors.initials: YJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D020266:Radiotherapy, Conformal; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies; D013116:Spinal Cord / Q000528:radiation effects; D013524:Surgical Flaps; D016896:Treatment Outcome