title: Inflammatory markers and visceral fat are inversely associated with maximal oxygen consumption in women with polycystic ovary syndrome (PCOS).
abstract: BACKGROUND
  We investigated whether several different inflammatory markers including C-reactive protein (CRP) and fibrinogen and white blood cells (WBCs) count, are associated with maximal oxygen consumption (VO(2 max)) in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  In PCOS women (n = 124, 24.1 +/- 4.5 year-old) VO(2 max) was measured during symptom-limited cardiopulmonary exercise test. Abdominal fat distribution was determined by ultrasound. Physical activity level was assessed by a standardized questionnaire. CRP was measured by immunoassays, fibrinogen by the Clauss method, and WBCs count with a Coulter counter.
  
  
  RESULTS
  Pearson's analysis showed a significant correlation between VO(2 max) and logCRP (r = -0.437, P < 0.001), fibrinogen (r = -0.479, P < 0.001), and WBCs count (r = -0.438, P < 0.001). Multivariable logistic regression model showed that age (beta = -0.127, P = 0.005), AUC(INS )(beta = -0.335, P < 0.001), HDL-C (beta = 0.390, P < 0.001), physical activity score (beta = 0.238, P = 0.002), visceral fat (beta =-0.184), P = 0.023), FAI (beta = -0.291, P = 0.028); CRP (beta = -0.216, P = 0.011), fibrinogen (beta = -0.113, P = 0.008) and WBCs count (beta = -0.177, P < 0.001) were significantly associated with VO(2 max).
  
  
  CONCLUSIONS
  Acute-phase reactants, such as CRP and fibrinogen, and WBCs count were independently and inversely associated with a direct measure of cardiorespiratory fitness (VO(2 max)) in women with PCOS, even after adjustment for physical activity level and other potential confounding factors. These findings add to the growing body of evidence linking inflammation to cardiorespiratory fitness in PCOS women.
authors.affiliation: Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Cardiac Rehabilitation Unit, Federico II University of Naples, Naples, Italy. giallauria@libero.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Giallauria
authors.forename: Stefano
authors.initials: S
authors.lastname: Palomba
authors.forename: Ilario
authors.initials: I
authors.lastname: De Sio
authors.forename: Luigi
authors.initials: L
authors.lastname: Maresca
authors.forename: Laura
authors.initials: L
authors.lastname: Vuolo
authors.forename: Silvia
authors.initials: S
authors.lastname: Savastano
authors.forename: Gaetano
authors.initials: G
authors.lastname: Lombardi
authors.forename: Annamaria
authors.initials: A
authors.lastname: Colao
authors.forename: Carlo
authors.initials: C
authors.lastname: Vigorito
authors.forename: Francesco
authors.initials: F
authors.lastname: Orio
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism; D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D002319:Cardiovascular System / Q000503:physiopathology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging*; D007958:Leukocyte Count; D016015:Logistic Models; D009043:Motor Activity / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000503:physiopathology*; D012137:Respiratory System / Q000503:physiopathology; D012189:Retrospective Studies; D014463:Ultrasonography
chemical_list: D000209:Acute-Phase Proteins; D005340:Fibrinogen; D002097:C-Reactive Protein