title: Aberrant aquaporin 5 expression in the sweat gland in aquagenic wrinkling of the palms.
abstract: Aquagenic wrinkling of the palms (AWP) is an uncommon disease characterized by the rapid and transient formation of edematous whitish plaques on the palms on exposure to water. Although this disease is occasionally accompanied by hyperhidrosis, the pathophysiology of AWP remains unknown. Herein we describe a patient with AWP. The location of wrinkling was limited to the areas positive for iodine-starch test after water exposure, which suggests that AWP is etiologically related to hyperhidrosis. Histologic examination revealed hyperplastic and papillated eccrine glandular epithelium with the enlarged diameter of eccrine coils. Immunohistochemically, while aquaporin 5 (AQP5), one of the water channel AQP families, was present exclusively in the dark cells of sweat glands of healthy donors, an aberrant AQP5 staining, extending to the clear cells, was found in the patient with AWP. The hyperplastic glandular epithelium and aberrant AQP5 staining in the patient's sweat glands suggest that AWP stems from dysregulation of sweating.
authors.affiliation: Department of Dermatology, University of Environmental and Occupational Health, Kitakyushu, Japan. kkabashi@med.uoeh-u.ac.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Kabashima
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Shimauchi
authors.forename: Miwa
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Shoko
authors.initials: S
authors.lastname: Fukamachi
authors.forename: Chika
authors.initials: C
authors.lastname: Kawakami
authors.forename: Makiko
authors.initials: M
authors.lastname: Ogata
authors.forename: Rieko
authors.initials: R
authors.lastname: Kabashima
authors.forename: Tomoko
authors.initials: T
authors.lastname: Mori
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ota
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukushima
authors.forename: Mariko
authors.initials: M
authors.lastname: Hara-Chikuma
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Tokura
mesh_terms: D000328:Adult; D051402:Aquaporin 5 / Q000378:metabolism*; D001706:Biopsy; D006229:Hand Dermatoses / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D015595:Skin Aging / Q000473:pathology*; D013545:Sweat Glands / Q000378:metabolism*; D014867:Water / Q000378:metabolism
chemical_list: C496036:AQP5 protein, human; D051402:Aquaporin 5; D014867:Water