[Expression of bone morphogenetic proteins, matrix metalloproteinases and inhibitors of matrix metalloproteinases in lung cancers and their prognostic significance].
Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are one of the molecules that have become a topic of great interest among scientists studying lung cancers. There is a distinct tendency toward higher expression of selected MMP and TIMP in tumor lung tissue. Furthermore, there is a significant correlation between high expression of TIMP-1 or MMP-2 in lung cancer and shortened survival and between high expression of TIMP-1 or MMP-7 in lung cancer and higher stage of disease. There have been only a few articles about the role of bone morphogenetic proteins (BMP) in lung cancer pathogenesis published so far in which BMP-2 or BMP-4 were overexpressed. It was also shown that BMP-2 stimulates tumor growth while BMP-4 inhibits it. This article is mainly concentrated on the expression of MMP, TIMP and BMP in lung cancers, but also it shows the significance of these proteins.
Bieniasz
Magdalena
M
Zakład Biochemii Medycznej, Katedra Biochemii Medycznej, Uniwersytet Medyczny w Lodzi. madicom@wp.pl
Bartkowiak
Jacek
J
Szemraj
Janusz
J
D019485:Bone Morphogenetic Proteins / Q000096:biosynthesis*; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D020782:Matrix Metalloproteinases / Q000096:biosynthesis*; D011379:Prognosis; D019714:Tissue Inhibitor of Metalloproteinases / Q000096:biosynthesis*
D019485:Bone Morphogenetic Proteins; D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases