title: The influence of dissolved oxygen tension on the synthesis of the antibiotic difficidin by bacillus subtilis.
abstract: The antibiotic, difficidin, and its hydroxylated derivative oxydifficidin, were synthesized by cultures of Bacillus subtilis grown on a complex medium. Maximum titers of about 200 and 130 mg/L, respectively, were obtained. In fermentations where the dissolved oxygen tension (DOT) was controlled, the maximum specific growth rate was only reduced below 5% air saturation. DOT had little effect on the volumetric rateof synthesis of oxydifficidin but greatly influenced the rate for difficidin, which was reduced at DOT values below 40% air saturation. (c) 1994 John Wiley & Sons, Inc.
authors.affiliation: The Advanced Centre for Biochemical Engineering, Department of Chemical and Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Suphantharika
authors.forename: A P
authors.initials: AP
authors.lastname: Ison
authors.forename: M D
authors.initials: MD
authors.lastname: Lilly
authors.forename: B C
authors.initials: BC
authors.lastname: Buckland