title: Cholesterol ester transfer protein: a therapeutic target in atherosclerosis?
abstract: BACKGROUND
  CETP has an established role in the transport of cholesterol from the peripheral tissues to the liver for elimination. The fact that CETP was recognized as a target for raising high-density lipoprotein cholesterol (HDL-C) levels has led to research on CETP inhibitors to protect against atherosclerosis.
  
  
  OBJECTIVE
  To review the role of CETP as a pivotal target for atherosclerosis and cardiovascular diseases and the effect of its overexpression or inhibition on lipid metabolism.
  
  
  METHODS
  A review of literature on the role of CETP in cholesterol metabolism and on recent developments on CETP inhibitors.
  
  
  CONCLUSIONS
  Animal and human studies have provided evidence supporting both the pro- and antiatherogenic roles of CETP. Clinical trials with CETP inhibitors remain under serious consideration. Further studies are necessary for understanding of the role of CETP in lipid metabolism and the development of novel therapies involving a combination of strategies for treatment of atherosclerosis and cardiovascular disease.
authors.affiliation: Harokopio University, Department of Science in Dietics and Nutrition, 70, El. Venizelou Street, GR 176 71 Athens, Greece.
authors.forename: Ekaterini
authors.initials: E
authors.lastname: Vourvouhaki
authors.forename: George V
authors.initials: GV
authors.lastname: Dedoussis
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000517:prevention & control*; D053480:Cholesterol Ester Transfer Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D011110:Polymorphism, Genetic; D011817:Rabbits
chemical_list: D053480:Cholesterol Ester Transfer Proteins; D000960:Hypolipidemic Agents