Systematic assessment of gamma hydroxybutyrate (GHB) effects during and after acute intoxication.
We adapted and tested a previously published questionnaire battery eliciting sensory and cognitive symptoms during (acute) and immediately after (post-acute) GHB intoxication. Studying 125 GHB users, we assessed the instrument's internal consistency using Cronbach's alpha (CA) and responsiveness to change comparing acute and post-acute symptoms. The final 14-item battery demonstrated good internal consistency (CA >or= 0.85, both acute and post-acute). The median symptom score (possible range 0-64) was 30 (acute) and 6 (post-acute; difference p < 0.001). This modified substance-specific symptom battery, which is easily administered, demonstrated excellent performance characteristics. It can be used to study GHB and, potentially, related drugs of abuse.
Kim
Susan Y
SY
California Poison Control System, Department of Clinical Pharmacy, San Francisco, University of California, San Francisco, California 94143-1369, USA. susank@calpoison.org
Barker
Judith C
JC
Anderson
Ilene B
IB
Dyer
Jo Ellen
JE
Earnest
Gillian
G
Blanc
Paul D
PD
D000759:Adjuvants, Anesthesia / Q000633:toxicity*; D000328:Adult; D000339:Affect / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D005260:Female; D017144:Focus Groups; D006306:Health Surveys; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D009042:Motivation; D011597:Psychomotor Performance / Q000187:drug effects*; D012907:Smoking / Q000453:epidemiology; D012978:Sodium Oxybate / Q000633:toxicity*; D019966:Substance-Related Disorders / Q000523:psychology*; D011795:Surveys and Questionnaires; D014481:United States
D000759:Adjuvants, Anesthesia; D012978:Sodium Oxybate