Cutaneous Rosai-Dorfman disease.
A 63-year-old woman developed multiple nodules at the site of a recently biopsied proliferation of CD 68+ histiocytes. Clinical lymphadenopathy was not present on physical examinaton or on computed tomography scans. A subsequent skin biopsy specimen showed changes consistent with Rosai-Dorfman disease. Rosai-Dorfman disease is a benign, histiocytic proliferative disorder also known as sinus histiocytosis with massive lymphadenopthy. A particularly rare, extranodal, purely cutaneous form has been described. Spontaneous regression tends to occur over months to years, with surgical intervention remaining the most effective treatment. Documented success with a number of other therapies has been reported, which include systemic high-dose thalidomide in extensive cutaneous disease.
Merola
Joseph F
JF
Department of Dermatology, New York University, USA.
Pulitzer
Melissa
M
Rosenman
Karla
K
Brownell
Isaac
I
D015703:Antigens, CD / Q000276:immunology; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology; D001706:Biopsy; D049109:Cell Proliferation; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006644:Histiocytes / Q000276:immunology / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D012871:Skin Diseases / Q000175:diagnosis* / Q000276:immunology; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule