title: Projections from the anterior interposed nucleus to the red nucleus diminish with age in the mouse.
abstract: To analyse the effect of ageing on the projection of the anterior interposed nucleus to the red nucleus, we injected the retrograde tracer fluorogold in the red nucleus of 3-, 6- and 12-month-old mice. The number of labelled neurones in the anterior interposed nucleus fell by 9% between 3 and 6 months and by another 9% between 6 and 12 months (all P < 0.001). This suggests that loss of neurones from the cerebellar nuclei starts well before old age.
authors.affiliation: Department of Morphology, Universidade Federal de São Paulo, SP, Brazil.
authors.forename: H H V
authors.initials: HH
authors.lastname: Olyntho-Tokunaga
authors.forename: M L
authors.initials: ML
authors.lastname: Pinto
authors.forename: C
authors.initials: C
authors.lastname: Souccar
authors.forename: G H M
authors.initials: GH
authors.lastname: Schoorlemmer
authors.forename: R C R S
authors.initials: RC
authors.lastname: Lapa
mesh_terms: D000344:Afferent Pathways / Q000033:anatomy & histology*; D000375:Aging / Q000502:physiology*; D000818:Animals; D001931:Brain Mapping; D002529:Cerebellar Nuclei / Q000166:cytology* / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009410:Nerve Degeneration / Q000378:metabolism; D009474:Neurons / Q000473:pathology / Q000502:physiology*; D012012:Red Nucleus / Q000033:anatomy & histology / Q000166:cytology* / Q000378:metabolism; D013194:Staining and Labeling