title: Severe hypothyroidism after contrast enema in premature infants.
abstract: Premature newborns are particularly vulnerable to iatrogenic hypothyroidism due to iodine exposure, usually through skin absorption of iodine-containing disinfectants or intravenous administration of iodinated contrast agents. We report here a case of severe iatrogenic hypothyroidism with goiter and cholestasis, discovered six weeks after a contrast enema using sodium ioxitalamate, an iodinated contrast agent. Prematurity, intrauterine growth retardation, and enteral feeding intolerance could explain why this complication occurred after contrast enema. Our observations suggest that indications of contrast enema in neonates need to be carefully considered, and when necessary, thyroid function should be monitored, especially in very premature infants.
authors.affiliation: CHU de Montpellier, Service de Néonatologie (Pédiatrie 2), Hôpital A. de Villeneuve, Montpellier, 34000, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Lombard
authors.forename: Fabienne
authors.initials: F
authors.lastname: Dalla-Vale
authors.forename: Corinne
authors.initials: C
authors.lastname: Veyrac
authors.forename: Odile
authors.initials: O
authors.lastname: Plan
authors.forename: Gilles
authors.initials: G
authors.lastname: Cambonie
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Picaud
mesh_terms: D002779:Cholestasis / Q000139:chemically induced / Q000175:diagnosis; D003287:Contrast Media / Q000009:adverse effects*; D004733:Enema / Q000009:adverse effects*; D006042:Goiter / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D007049:Iatrogenic Disease; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D007455:Iodine / Q000009:adverse effects*; D008297:Male; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use; D014284:Triiodothyronine / Q000097:blood; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine