Production of transgenic farm animals by viral vector-mediated gene transfer.
Transgenic technology holds considerable promise to advance understanding in biomedical and agricultural systems with some believing that one day transgenic animals may directly contribute to farming and breeding practice. Nevertheless, applications in livestock have been restricted in part by the inefficiency of the technology. The recent development of lentivirus vectors for transgene delivery may overcome some of this limitation. This presentation describes these vectors, their advantages and limitations.
Whitelaw
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CB
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK. bruce.whitelaw@roslin.ed.ac.uk
Lillico
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SG
King
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D000818:Animals; D000829:Animals, Domestic; D030801:Animals, Genetically Modified; D018014:Gene Transfer Techniques / Q000662:veterinary*; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000235:genetics*; D016086:Lentivirus / Q000235:genetics*; D016254:Mutagenesis, Insertional; D019076:Transgenes / Q000235:genetics*