[Cancer chemoprevention-basic and clinical aspects].
Cancer chemoprevention is the use of agents to inhibit, delay or reverse carcinogenesis, and was proposed in the United States in view of the cost-benefits. Since recent progress in molecular biology revealed several signal transduction routes in carcinogenesis, the search for mechanism-based chemopreventive agents is under way. Many chemopreventive clinical trials for various cancers including colorectal cancer, prostate cancer and breast cancer, have been performed. Chemoprevention to eradicate viruses or bacteria such as hepatitis viruses or Helicobacter pylori is also important in order to prevent development of cancer.
Takayama
Tetsuji
T
Dept. of Gastroenterology and Oncology, Institutes of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
Okamura
Seisuke
S
Okahisa
Toshiya
T
Kaji
Masako
M
Takeuchi
Hisashi
H
Kimura
Tetsuo
T
D000818:Animals; D018890:Chemoprevention; D004195:Disease Models, Animal; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control* / Q000821:virology; D014777:Virus Diseases / Q000150:complications