title: Hyperosmolar, increased-anion-gap metabolic acidosis and hyperglycemia after etomidate infusion.
abstract: Hyperosmolar increased-anion-gap metabolic acidosis without hyperglycemia has been reported after infusions of etomidate and other medications containing propylene glycol. We report a case of this biochemical abnormality with severe hyperglycemia. Cessation of the etomidate infusion along with other supportive measures resulted in prompt resolution of the metabolic acidosis and hyperglycemia.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, and University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4399, USA. ganesha@email.chop.edu
authors.forename: Arjunan
authors.initials: A
authors.lastname: Ganesh
authors.forename: Paul
authors.initials: P
authors.lastname: Audu
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000138:Acidosis / Q000139:chemically induced*; D000328:Adult; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D001774:Blood Chemical Analysis; D005045:Etomidate / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D019946:Propylene Glycol / Q000378:metabolism / Q000506:poisoning; D012997:Solvents / Q000378:metabolism / Q000506:poisoning; D016896:Treatment Outcome
chemical_list: D018686:Anesthetics, Intravenous; D012997:Solvents; D019946:Propylene Glycol; D005045:Etomidate