Anthraquinones from the roots of Prismatomeris malayana.
A novel anthraquinone, 1,3-dihydroxy-5,6-dimethoxy-2-methoxymethyl-9,10-anthraquinone (9) and a new natural product, 2-hydroxymethyl-1-methoxy-9,10-anthraquinone (8) were isolated from the roots of Prismatomeris malayana together with seven known anthraquinones, tectoquinone (1), 1-hydroxy-2-methyl-9,10-anthraquinone (2), rubiadin (3), rubiadin-1-methyl ether (4), 1,3-dihydroxy-5,6-dimethoxy-2-methyl-9,10-anthraquinone (5), nordamnacanthal (6), and damnacanthal (7). Their structures were determined on the basis of spectroscopic data. Some of the anthraquinones were tested for anticancer, antifungal, and antimalarial activities.
Tuntiwachwuttikul
Pittaya
P
Faculty of Science, Department of Chemistry, Silpakorn University, Nakorn Pathom 73000, Thailand. pittayat@su.ac.th
Butsuri
Yuttapon
Y
Sukkoet
Piyanut
P
Prawat
Uma
U
Taylor
Walter Charles
WC
D000447:Aldehydes / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D019666:Rubiaceae / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
C534270:1,3-dihydroxy-5,6-dimethoxy-2-methoxymethyl-9,10-anthraquinone; C534271:2-hydroxymethyl-1-methoxy-9,10-anthraquinone; D000447:Aldehydes; D000880:Anthraquinones; D000935:Antifungal Agents; D000962:Antimalarials; D000970:Antineoplastic Agents; C465644:nordamnacanthal; C042834:9,10-anthraquinone; C079170:damnacanthal; C079172:rubiadin 1-methyl ether; C072500:rubiadin