title: Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria.
abstract: An early SAR study of a screening hit series has generated a series of 9-benzyl purines as inhibitors of bacterial glutamate racemase (MurI) with micromolar enzyme potency and improved physical properties. X-ray co-crystal EI structures were obtained.
authors.affiliation: AstraZeneca R&D Boston, Infection Discovery, 35 Gatehouse Drive, Waltham, MA 02451, USA. bolin.geng@astrazeneca.com
authors.forename: Bolin
authors.initials: B
authors.lastname: Geng
authors.forename: Gloria
authors.initials: G
authors.lastname: Breault
authors.forename: Janelle
authors.initials: J
authors.lastname: Comita-Prevoir
authors.forename: Randy
authors.initials: R
authors.lastname: Petrichko
authors.forename: Charles
authors.initials: C
authors.lastname: Eyermann
authors.forename: Tomas
authors.initials: T
authors.lastname: Lundqvist
authors.forename: Peter
authors.initials: P
authors.lastname: Doig
authors.forename: Elise
authors.initials: E
authors.lastname: Gorseth
authors.forename: Brian
authors.initials: B
authors.lastname: Noonan
mesh_terms: D000591:Amino Acid Isomerases / Q000037:antagonists & inhibitors*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D013293:Enterococcus faecalis / Q000187:drug effects / Q000235:genetics; D016984:Enterococcus faecium / Q000187:drug effects / Q000235:genetics; D006094:Gram-Positive Bacteria / Q000201:enzymology* / Q000235:genetics; D008968:Molecular Conformation; D015394:Molecular Structure; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D011687:Purines; D000591:Amino Acid Isomerases; C062292:glutamate racemase