title: (-)-Xanthienopyran, a new inhibitor of superoxide anion generation by activated neutrophils, and further constituents of the seeds of Xanthium strumarium.
abstract: The dried seeds of XANTHIUM STRUMARIUM (Asteraceae) are used after thorough stir-frying as an ingredient in traditional Chinese medicines for relieving allergy. Two new compounds, xanthialdehyde ( 2) and (-)-xanthienopyran ( 7), as well as 26 known compounds were isolated in the present study. The structures of the isolates were elucidated by spectroscopic methods. Among them, compound 7 exhibited significant selective inhibition of superoxide anion generation by human neutrophils induced by formyl- L-methionyl- L-leucyl- L-phenylalanine, with an IC50 value of 1.72 microg/mL.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Chia-Lin
authors.initials: CL
authors.lastname: Lee
authors.forename: Po-Ching
authors.initials: PC
authors.lastname: Huang
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Hsieh
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Yu-Yi
authors.initials: YY
authors.lastname: Hou
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D045744:Cell Line, Tumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D013481:Superoxides / Q000378:metabolism*; D014970:Xanthines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031210:Xanthium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D011714:Pyrans; D014970:Xanthines; C532418:xanthialdehyde; C532419:xanthienopyran; D013481:Superoxides