The prokinetic effect of mosapride citrate on horse gastric emptying rates.
The prokinetic effect of the 5-HT4 receptor agonist mosapride was evaluated in seven healthy thoroughbreds. Mosapride was orally administered at doses of 0.5, 1.0 or 1.5 mg/kg. The breath 13CO2/12CO2 rate (Delta13CO2), an indirect indicator for the rate of gastric emptying, was measured at appropriate points for 4 hr after drug administration. There was a significant increase compared with the control value at 15, 20 and 165 min for 0.5 mg/kg, 30 min at 1.0 mg/kg and 165 min for 1.5 mg/kg. The results suggest that mosapride may facilitate the gastric emptying in horses.
Okamura
Koichi
K
The United Graduate School of Veterinary Sciences, Gifu University, Gifu-shi, Japan.
Sasaki
Naoki
N
Fukunaka
Morito
M
Yamada
Haruo
H
Inokuma
Hisashi
H
D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D001944:Breath Tests; D002245:Carbon Dioxide / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D005746:Gastric Emptying / Q000187:drug effects* / Q000502:physiology; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006736:Horses / Q000502:physiology*; D009025:Morpholines / Q000494:pharmacology*
D001549:Benzamides; D005765:Gastrointestinal Agents; D009025:Morpholines; D002245:Carbon Dioxide; C062720:mosapride