title: Hyperhomocysteinemia, antithrombin consumption, and early venous graft closure in surgical coronary revascularization.
abstract: Hyperhomocysteinemia is a pathological condition that increases cardiovascular risk due to prothrombotic behaviour in the patient. This case report concerns a 61-year-old man undergoing surgical coronary revascularization for early thrombosis of the venous graft. The postoperative antithrombin activity was extremely low (33%), despite normal preoperative values (79%) and a short cardiopulmonary bypass. At a subsequent screening, the patient was diagnosed with hyperhomocysteinemia (18.4 mmol/L) due to a heterozygous C677T mutation of the enzyme methylenetetrahydrofolate reductase associated with a folate deficiency. Hyperhomocysteinemia and cardiac operation are both factors that induce increased thrombin formation, which may induce antithrombin consumption and a consequent thrombotic event. Further studies are needed to define hyperhomocysteinemia as an independent risk factor for thrombotic events after cardiac surgery.
authors.affiliation: Department of Cardiothoracic-Vascular Anesthesia and Intensive Care, Polyclinic Hospital S. Donato IRCCS, Milan, Italy. cardioanestesia@virgilio.it
authors.forename: M
authors.initials: M
authors.lastname: Ranucci
authors.forename: F
authors.initials: F
authors.lastname: Romitti
authors.forename: E
authors.initials: E
authors.lastname: Costa
mesh_terms: D000991:Antithrombins / Q000032:analysis*; D001026:Coronary Artery Bypass; D006801:Humans; D020138:Hyperhomocysteinemia / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012501:Saphenous Vein / Q000637:transplantation
chemical_list: D000991:Antithrombins