title: Febrile neutropenia in a bone marrow transplantation unit.
abstract: In our clinic, between May 1988 and December 1994, 117 bone marrow transplants (78 allogenic BMT (alloBMT), 26 autologous BMT (autoBMT), 13 autologous peripheral stem cell transplant (autoPSCT). Eighty-six (73.5%) febrile neutropenic episodes (FNEs) were encountered (64 alloBMTs, 15 autoBMTs, 7 autoPSCTs). There were 28 (32.5%) microbiologically documented infections, 18 (20.9%) clinically documented infections and 40 (46.5%) FUO. Gram-positive microorganisms were the most frequently isolated agents (57.1%) and Staphylococcus spp. were the main pathogens to cause bacteremia (%54.1). Enterobacter spp. were the most common (75%) in urinary tract infections, FNEs were most frequently (82%, 64 78 ) encountered in AlloBMT patients. No significant difference in the number of FNEs was found between autoBMT and autoPSCT groups (P < 0.05). Overall response rate to empirical antibiotherapy was 87.2% (75 86 ) and the success of treatment disclosed no difference in relation to transplant type and definition of infection (P > 0.05). Seven (6%) patients suffered from catheter infections and eight (7%) from Candida esophagitis.
authors.affiliation: Ankara University, Faculty of Medicine, Ibn-i Sina Hospital, Department of Hematology-Oncology, Sihhiye, 06 100, Ankara, Turkey. akanh@neuron.ato.org.tr
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