title: Acetaminophen-induced acute liver failure treated with single-pass albumin dialysis: report of a case.
abstract: BACKGROUND
  Acetaminophen (paracetamol) overdose is a leading cause of acute liver failure (ALF). When patients fulfill the King's College criteria for acetaminophen-induced ALF (AALF), they have a poor prognosis for survival without liver transplantation. Recent advances in artificial liver support have used albumin as a binding and scavenging molecule in ALF. One method, single-pass albumin dialysis (SPAD), involves dialyzing blood against an albumin-containing solution across a high-flux membrane to remove albumin-bound toxins. Herein, we describe our protocol for SPAD and report its use in a case of AALF as a bridge to native liver recovery.
  
  
  METHODS
  A 41-year-old female with no documented history of liver disease presented with acute acetaminophen toxicity and developed hepatic encephalopathy, coagulopathy and lactic acidosis. The patient met King's College criteria for liver transplantation, based on pH and INR, but was deemed not suitable as a candidate due to psychosocial comorbidities. On day 3 of her ICU admission, she received the first of five consecutive daily runs (total ~77 hours) of SPAD. The patient's course was complicated by cerebral edema requiring mannitol. She was extubated on day 11 and transferred to the ward by day 13. At ICU discharge, her liver function (INR 1.9, bilirubin 435 mmol/L) and kidney function were recovering. She did not have any long-term neurological sequelae. By hospital discharge (day 46) her native liver function had recovered with a bilirubin <100mmol/L.
  
  
  CONCLUSIONS
  We describe a case of a patient with acetaminophen-induced acute liver failure who was successfully bridged to spontaneous native liver recovery as a result of SPAD treatment. In patients with ALF, SPAD may be an additional intervention for temporary extracorporeal support. Further investigation in larger prospective studies is warranted.
authors.affiliation: Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta - Canada.
authors.forename: C J
authors.initials: CJ
authors.lastname: Karvellas
authors.forename: S M
authors.initials: SM
authors.lastname: Bagshaw
authors.forename: R C
authors.initials: RC
authors.lastname: McDermid
authors.forename: D E
authors.initials: DE
authors.lastname: Stollery
authors.forename: R T
authors.initials: RT
authors.lastname: Gibney
mesh_terms: D000082:Acetaminophen / Q000506:poisoning*; D000328:Adult; D000418:Albumins / Q000008:administration & dosage*; D018712:Analgesics, Non-Narcotic / Q000506:poisoning*; D003956:Dialysis / Q000379:methods*; D015314:Dialysis Solutions / Q000737:chemistry; D062787:Drug Overdose / Q000150:complications; D005260:Female; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000628:therapy*; D019164:Liver, Artificial
chemical_list: D000418:Albumins; D018712:Analgesics, Non-Narcotic; D015314:Dialysis Solutions; D000082:Acetaminophen