[Study on antitumor activity of extract from roots of Gossampinus malabaria].
OBJECTIVE
To study the antitumor activity of extract (Y2) from the roots of Gossampinus malabaria (L.) Merr.


METHODS
Based on the inhibitory effects of Y2 on FGC-85 in vitro, life-prolonging effects of Y2 on mice transplanted with ascites sarcoma-180 (S-180) and antitumor activity of Y2 on mice transplanted with U14 were investigated in vivo.


RESULTS
The growth of S-180 in mice was significantly inhibited by Y2. The inhibitory growth effect was dosage-dependent. Y2 could significantly prolong the survival time of mice transplanted with S-180. The inhibition rate of Y2 on the growth of U14 in mice was higher than 90% under high, medium and low dosage.


CONCLUSIONS
Y2 has distinct antitumor activity.
Qi
Yi-Ping
YP
Fujian Provincial Institute of Medical Sciences, Fuzhou 350001, China.
Zhu
Hui
H
Guo
Shun-Min
SM
Jue
Hui-Qing
HQ
Lin
Sui
S
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D035161:Bombacaceae; D035163:Bombax / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000473:pathology; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D003520:Cyclophosphamide