Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors.
We report here a comparative study of the anti-hepatitis C virus (HCV) activities of selected (i) nucleoside polymerase, (ii) nonnucleoside polymerase, (iii) alpha,gamma-diketo acid polymerase, (iv) NS3 protease, and (v) helicase inhibitors, as well as (vi) cyclophilin binding molecules and (vii) alpha 2b interferon in four different HCV genotype 1b replicon systems.
Paeshuyse
Jan
J
Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Vliegen
Inge
I
Coelmont
Lotte
L
Leyssen
Pieter
P
Tabarrini
Oriana
O
Herdewijn
Piet
P
Mittendorfer
Harald
H
Easmon
Johnny
J
Cecchetti
Violetta
V
Bartenschlager
Ralf
R
Puerstinger
Gerhard
G
Neyts
Johan
J
D000998:Antiviral Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004265:DNA Helicases / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D016174:Hepacivirus / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D011480:Protease Inhibitors / Q000494:pharmacology*; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors; D012093:Replicon / Q000187:drug effects / Q000235:genetics; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D011480:Protease Inhibitors; D012324:RNA-Dependent RNA Polymerase; D004265:DNA Helicases