Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives.
Some novel substituted pyrazole and pyrazolo[3,4-d]pyrimidine derivatives 2, 4, 8, and 9 were synthesized. Also, some acyclic S-nucleosides of pyrazolo[3,4-d]pyrimidine derivatives 10-13 were prepared via reaction of pyrazolo[3,4-d]pyrimidine-4(3H)-thione derivative 9 with some acyclic sugars. Moreover, the N-nucleoside derivative 14 was prepared via reaction of compound 8 with glucosamine hydrochloride. The antiviral evaluation of some selected new products showed that they have promising antiviral activity against hepatitis-A virus (HAV) and herpes simplex virus type-1 (HSV-1).
Rashad
Aymn E
AE
Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt. aymnelzeny@yahoo.com
Hegab
Mohamed I
MI
Abdel-Megeid
Randa E
RE
Micky
Jehan A
JA
Abdel-Megeid
Farouk M E
FM
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D030041:Hepatitis A virus / Q000187:drug effects / Q000254:growth & development; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000254:growth & development; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D011720:Pyrazoles