title: Systematic assessment of gamma hydroxybutyrate (GHB) effects during and after acute intoxication.
abstract: We adapted and tested a previously published questionnaire battery eliciting sensory and cognitive symptoms during (acute) and immediately after (post-acute) GHB intoxication. Studying 125 GHB users, we assessed the instrument's internal consistency using Cronbach's alpha (CA) and responsiveness to change comparing acute and post-acute symptoms. The final 14-item battery demonstrated good internal consistency (CA >or= 0.85, both acute and post-acute). The median symptom score (possible range 0-64) was 30 (acute) and 6 (post-acute; difference p < 0.001). This modified substance-specific symptom battery, which is easily administered, demonstrated excellent performance characteristics. It can be used to study GHB and, potentially, related drugs of abuse.
authors.affiliation: California Poison Control System, Department of Clinical Pharmacy, San Francisco, University of California, San Francisco, California 94143-1369, USA. susank@calpoison.org
authors.forename: Susan Y
authors.initials: SY
authors.lastname: Kim
authors.forename: Judith C
authors.initials: JC
authors.lastname: Barker
authors.forename: Ilene B
authors.initials: IB
authors.lastname: Anderson
authors.forename: Jo Ellen
authors.initials: JE
authors.lastname: Dyer
authors.forename: Gillian
authors.initials: G
authors.lastname: Earnest
authors.forename: Paul D
authors.initials: PD
authors.lastname: Blanc
mesh_terms: D000759:Adjuvants, Anesthesia / Q000633:toxicity*; D000328:Adult; D000339:Affect / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D005260:Female; D017144:Focus Groups; D006306:Health Surveys; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D009042:Motivation; D011597:Psychomotor Performance / Q000187:drug effects*; D012907:Smoking / Q000453:epidemiology; D012978:Sodium Oxybate / Q000633:toxicity*; D019966:Substance-Related Disorders / Q000523:psychology*; D011795:Surveys and Questionnaires; D014481:United States
chemical_list: D000759:Adjuvants, Anesthesia; D012978:Sodium Oxybate