The use of solid lipid nanoparticles to target a lipophilic molecule to the liver after intravenous administration to mice.
Taspine solid lipid nanoparticles (Ta-SLN) and taspine solid lipid nanoparticles modified by galactoside (Ta-G2SLN) were prepared by the film evaporation-extrusion method. The nanoparticles were spherical or near-spherical particles with smooth surface, small size and high encapsulation efficiency. Ta-G2SLN and Ta-SLN showed significant inhibition on 7721 cell growth. Intravenous injection of either Ta-SLN or Ta-G2SLN resulted in a higher plasma and liver concentration and a longer retention time in mice compared with the administration of Ta. These results suggested that SLN tended to be preferentially delivered to the liver and Ta-G2SLN may further enhance liver targeting.
Lu
Wen
W
School of Medicine, Xi'an Jiaotong University, No. 76 Western Yanta Road, Xi'an 710061, PR China.
He
Lang Chong
LC
Wang
Chang He
CH
Li
Yan Hua
YH
Zhang
San Qi
SQ
D000470:Alkaloids / Q000008:administration & dosage* / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D005697:Galactosides / Q000737:chemistry; D007275:Injections, Intravenous; D008055:Lipids / Q000737:chemistry*; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*
D000470:Alkaloids; D004337:Drug Carriers; D005697:Galactosides; D008055:Lipids; C018394:taspine