title: Evaluation of adaptive changes by non-invasive imaging in hepatic vein outflow obstruction.
abstract: Hepatic vein outflow obstruction induces remarkable changes of intra-hepatic blood circulation; the significance of these changes remains uncertain. Six patients with obstruction of the hepatic veins were evaluated by duplex Doppler ultrasound and computed tomography. The adaptive changes secondary to obstruction were analyzed and their significance was correlated with the clinical findings. Four patients presenting unilateral hepatic vein occlusion had unilateral reversed portal flow. Two of them, with lobar liver atrophy and contralateral compensatory hypertrophy required operation; the other two, with normal appearance of the liver, benefitted from conservative treatment. Two patients with bilateral hepatic vein occlusion, intra-hepatic bypasses, bilateral lobar atrophy and caudate lobe hypertrophy, received operations. Intrahepatic unilateral portal flow reversal compensates for unilateral hepatic outflow obstruction. The combination of complete or subtotal hepatic vein obstruction and atrophy-hypertrophy complex predicates advanced disease despite flow reversal or spontaneous shunt.
authors.affiliation: Clinic of Visceral and Transplantation Surgery, Inselspital Bern, University of Bern, Bern 3010, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Gertsch
authors.forename: J N
authors.initials: JN
authors.lastname: Vauthey
authors.forename: C
authors.initials: C
authors.lastname: Looser
authors.forename: J
authors.initials: J
authors.lastname: Triller
authors.forename: L H
authors.initials: LH
authors.lastname: Blumgart