The microvascular architecture of the choroid plexus in fetal human brain lateral ventricle: a scanning electron microscopy study of corrosion casts.
The microvascular architecture of developing lateral ventricle choroid plexus was investigated by corrosion casting and scanning electron microscopy in human fetuses aged 20 gestational weeks. The areas with different microvascular patterns corresponded to the particular parts of the mature plexus: anterior part, glomus, posterior part, the villous fringe and the free margin. In the posterior part, densely packed parallel arterioles and venules were surrounded by sheath-like capillary networks. Other areas contained compact capillary plexuses of the primary villi: the most prominent, protruding basket- and leaf-shaped plexuses were observed in the villous fringe, whilst less numerous and smaller plexuses occurred in the anterior part and glomus. The capillaries of the plexuses had a large diameter and sinusoidal dilations, and showed the presence of occasional short, blind sprouts indicative of angiogenesis. Short anastomoses between arterioles supplying the plexuses and venules draining them were only rarely observed. In the upper area of the choroid plexus, the superior choroidal vein was surrounded by a capillary network forming small, glomerular or rosette-shapes plexuses. The free margin of the choroid plexus was characterized by flat, multiple, arcade-like capillary loops. The general vascular architecture of the human choroid plexus at 20 gestational weeks seems to be similar to that of postnatal/mature plexus, still lacking, however, the complex vascular plexuses of the secondary villi.
Zagorska-Swiezy
K
K
Laboratory of Scanning Electron Microscopy, Department of Otorhinolaryngology, Jagiellonian University Medical College, Krakow, Poland.
Litwin
J A
JA
Gorczyca
J
J
Pitynski
K
K
Miodonski
A J
AJ
D001160:Arterioles / Q000196:embryology / Q000648:ultrastructure; D002196:Capillaries / Q000196:embryology / Q000648:ultrastructure; D002831:Choroid Plexus / Q000098:blood supply* / Q000196:embryology* / Q000648:ultrastructure; D016319:Corrosion Casting; D005260:Female; D005865:Gestational Age; D006801:Humans; D020547:Lateral Ventricles / Q000098:blood supply / Q000196:embryology* / Q000648:ultrastructure; D008297:Male; D008855:Microscopy, Electron, Scanning; D011247:Pregnancy; D014699:Venules / Q000196:embryology / Q000648:ultrastructure