Getting the message out.
In a recent issue of Molecular Cell, Schwer (2008) demonstrates that, during the latest stage of the splicing reaction, the RNA-dependent helicase Prp22 is deposited upon the downstream exon, where it subsequently strips the spliced messenger RNA from the spliceosome.
McManus
C Joel
CJ
Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3301, USA.
Graveley
Brenton R
BR
D053487:DEAD-box RNA Helicases / Q000378:metabolism; D005091:Exons / Q000235:genetics; D012326:RNA Splicing / Q000235:genetics*; D017381:Spliceosomes / Q000378:metabolism; D013379:Substrate Specificity
D053487:DEAD-box RNA Helicases