Treatment of sleep disordered breathing in congestive heart failure.
In patients with congestive heart failure, sleep disordered breathing occurs commonly and is associated with an increased mortality. In addition to central sleep apnea (Cheyne-Stokes respiration), obstructive sleep apnea is more prevalent in patients with congestive heart failure than in the general population. As a result, a number of treatments have been investigated, with varying results. While many therapies may improve the severity of sleep disordered breathing, only positive pressure ventilation has been shown to improve cardiac function. Newer forms of positive pressure ventilation, such as adaptive servo-ventilation, appear to be even more effective at correcting central sleep apnea. Whether any of these treatments have an effect on transplant-free survival is presently unknown and awaits further study.
Krachman
Samuel L
SL
Division of Pulmonary and Critical Care Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA. krachms@tuhs.temple.edu
D'Alonzo
Gilbert E
GE
Permut
Irene
I
Chatila
Wissam
W
D002639:Cheyne-Stokes Respiration / Q000628:therapy*; D045422:Continuous Positive Airway Pressure; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D020182:Sleep Apnea, Central / Q000628:therapy*; D020181:Sleep Apnea, Obstructive / Q000628:therapy*; D016277:Ventricular Function, Left