[Studies on chemical constituents of Sarcandra glabra].
OBJECTIVE
To study antibacterial chemical constituents of Sarcandra glabra.


METHODS
The constituents of the chloroform and EtOAc-soluble portions of the EtOH extract from the whole plant of S. glabra, which posses the antibacterial activities, were isolated and purified with column chromatography. The compounds were identified by physical and spectroscopic techniques.


RESULTS
Six compounds were isolated and identified as 4, 4'-biisofraxidin (1), esculetin (2), fraxetin (3), scoparone (4), isofraxidin (5), scopoletin(6), respectively.


CONCLUSIONS
Compound 1 is a novel natural product. Compounds 24 were isolated from the plants of Chloranthaceae for the first time. The antibacterial activities of these six compounds were tested for the first time. Some compounds may have potential for future study and development as plant-derived oral antibacterial agents.
Xu
Xu-Dong
XD
Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100094, China. xdxu@implad.ac.cn
Hu
Xiao-Ru
XR
Yuan
Jing-Quan
JQ
Yang
Jun-Shan
JS
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D016966:Porphyromonas gingivalis / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013295:Streptococcus mutans / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003374:Coumarins; D004365:Drugs, Chinese Herbal