New insights of HLA class I association to Behçet's disease in Portuguese patients.
Human leukocyte antigen (HLA)-B*51 is a well-known genetic factor associated with Behçet's disease (BD). To analyse the influence of HLA-B*51 and other HLA class I alleles in BD susceptibility in a Portuguese population and its association with disease severity, we studied 78 BD patients and 208 healthy controls. The patients were classified into two severity groups as described by Gul et al. As expected, a higher frequency of HLA-B*51 was found. The frequency of HLA-Cw*16 alleles was significantly higher in patients. Regarding severity, HLA-B*27 frequency was higher in the severe group compared with controls and with the mild group. Thus, HLA-B*51 and HLA-Cw*16 seem to confer susceptibility to BD in this patients. HLA-B*27 may be important as a prognostic factor.
Bettencourt
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A
Immunogenetics Laboratory, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Unidade Multidisciplinar de Investigação Biomédica (UMIB), Porto, Portugal. ambettencourt@icbas.up.pt
Pereira
C
C
Carvalho
L
L
Carvalho
C
C
Patto
J V
JV
Bastos
M
M
Silva
A M
AM
Barros
R
R
Vasconcelos
C
C
Paiva
P
P
Costa
L
L
Costa
P P
PP
Mendonça
D
D
Correia
J
J
Silva
B M
BM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics*; D001528:Behcet Syndrome / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D015235:HLA-B Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen / Q000235:genetics*; D059949:HLA-B51 Antigen; D006801:Humans; D008297:Male; D058950:Melanoma-Specific Antigens; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D011174:Portugal / Q000453:epidemiology
D000951:Antigens, Neoplasm; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D059949:HLA-B51 Antigen; C072011:MAGEA1 protein, human; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins