title: 1,5-Benzothiazepine, a versatile pharmacophore: a review.
abstract: 1,5-Benzothiazepine and 1,5-benzodiazipine are the two main seven-membered heterocyclic ring systems reported for their cardiac and psychotherapeutic activities. Successful introduction of diltiazem and clentiazem for angina pectoris, hypertension, arrhythmias and other related cardiac disorders proved potential of 1,5-benzothiazepine moiety. Subsequently 1,5-benzodiazepines were highlighted as important biologically active scaffolds. Also, discovery of thiazesim and quetiapine fumarate as psychotropic agents attracted much attention worldwide. The current review article focuses on pharmacological profile associated with 1,5-benzodiazepines. This article mainly covers structural modifications done for various targets along with the brief description of the targets.
authors.affiliation: Department of Chemistry, Saurashtra University, Rajkot 360 005, Gujarat, India.
authors.forename: Jitender B
authors.initials: JB
authors.lastname: Bariwal
authors.forename: Kuldip D
authors.initials: KD
authors.lastname: Upadhyay
authors.forename: Atul T
authors.initials: AT
authors.lastname: Manvar
authors.forename: Jalpa C
authors.initials: JC
authors.lastname: Trivedi
authors.forename: Jyoti S
authors.initials: JS
authors.lastname: Singh
authors.forename: Kishor S
authors.initials: KS
authors.lastname: Jain
authors.forename: Anamik K
authors.initials: AK
authors.lastname: Shah
mesh_terms: D000818:Animals; D001569:Benzodiazepines / Q000737:chemistry* / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000737:chemistry; D002147:Calmodulin / Q000037:antagonists & inhibitors / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects
chemical_list: D002121:Calcium Channel Blockers; D002147:Calmodulin; D001569:Benzodiazepines