title: [Ethnic differences of genetic polymorphisms in cancer chemotherapy].
abstract: The frequency of polymorphisms of CDA was analyzed and the correlation between polymorphisms of CDA and toxicity was evaluated. CDA*3 genotype strongly influenced the metabolism of the drugs and patients with CDA*3 homotype experienced severe toxicity, and the frequency differed among persons of different ethnic origin. Ethnic differences in PK and PD were demonstrated by common arm trials in USA and Japan. Pharmacogenomic differences which determine them should be more intensively been studied.
authors.affiliation: National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
authors.forename: Nagahiro
authors.initials: N
authors.lastname: Saijyo
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003564:Cytidine Deaminase / Q000235:genetics / Q000378:metabolism; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics*; D000093542:Gemcitabine
chemical_list: D000970:Antineoplastic Agents; D003841:Deoxycytidine; D003564:Cytidine Deaminase; D000093542:Gemcitabine