title: Factors distinguishing general practitioners who more readily participated in a large randomized trial were identified.
abstract: OBJECTIVE
  To investigate factors associated with the successful recruitment of general practices to a randomized controlled trial.
  
  
  METHODS
  Analysis of accrual of primary care centers to a randomized controlled trial in the UK.
  
  
  RESULTS
  Those practices promptly agreeing to take part had better target achievement and a higher proportion of white British residents locally. Participating practices had a mean Quality and Outcomes Framework attainment of 92% of the points available, whereas nonparticipating practices achieved 88% (P=0.009). Participating practices were located in areas with a higher proportion of white British residents (mean 89%), in comparison to nonparticipating practices (mean 84%, P=0.004). Reasons given by practices to explain nonparticipation were primarily related to internal factors, with 38% of practices approached saying that they could not participate for such reasons.
  
  
  CONCLUSIONS
  There are some small differences between participating practices and nonparticipants in achievement of government targets and in the local ethnic mix. The primary reason given by practices for nonparticipation was workload or time pressures, with over a third of practices reporting being prevented by issues relating to practice organization. It may be that practices with workload or organizational difficulties require additional support to participate in research.
authors.affiliation: Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK. liz.down@bristol.ac.uk
authors.forename: Liz
authors.initials: L
authors.lastname: Down
authors.forename: Chris
authors.initials: C
authors.lastname: Metcalfe
authors.forename: Kerry
authors.initials: K
authors.lastname: Avery
authors.forename: Sian
authors.initials: S
authors.lastname: Noble
authors.forename: J Athene
authors.initials: JA
authors.lastname: Lane
authors.forename: David E
authors.initials: DE
authors.lastname: Neal
authors.forename: Freddie C
authors.initials: FC
authors.lastname: Hamdy
authors.forename: Jenny L
authors.initials: JL
authors.lastname: Donovan
mesh_terms: D001291:Attitude of Health Personnel; D055088:Early Detection of Cancer; D005194:Family Practice / Q000458:organization & administration*; D006801:Humans; D008297:Male; D010821:Physicians, Family; D011320:Primary Health Care / Q000458:organization & administration*; D011365:Professional Practice Location; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000628:therapy; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*; D006113:United Kingdom; D000078329:Workforce; D016526:Workload