title: Whole-body biodistribution and radiation dosimetry of the new cardiac tracer 99mTc-N-DBODC.
abstract: Our purpose was to evaluate the safety profile and biodistribution behavior in healthy human volunteers of the new myocardial perfusion tracer bis[(dimethoxypropylphosphanyl)ethyl]ethoxyethylamine N,N'-bis(ethoxyethyl)dithiocarbamato nitrido technetium(V) (99mTc-N-DBODC).
  
  
  METHODS
  Ten healthy male volunteers were injected with 99mTc-N-DBODC under both stress and rest conditions. Anterior and posterior planar gamma-camera images were collected at 5, 30, 60, 240, and 1,440 min after injection, with organ uptake quantified by region-of-interest analysis. Tracer kinetics in body fluids were determined by collecting blood and urine samples at different time points.
  
  
  RESULTS
  After injection, 99mTc-N-DBODC showed significant accumulation in the myocardium and prolonged retention. Under rest conditions, uptake in the heart, lungs, and liver at 5 min after injection was 1.67% +/- 0.13%, 1.16% +/- 0.07%, and 10.85% +/- 1.72%, respectively, of administered activity. Under stress conditions, heart uptake was significantly higher (2.07% +/- 0.22%). Radioactivity in the liver decreased to 3.64% +/- 0.98% and 2.37% +/- 0.48% at 60 and 240 min, respectively, after injection. This rapid liver clearance led to favorable heart-to-liver ratios, reaching values of 0.74 +/- 0.13 at rest and 1.26 +/- 0.28 during exercise 60 min after tracer administration. Radiation dose estimates were comparable to those obtained with other myocardial perfusion cationic compounds.
  
  
  CONCLUSIONS
  The high uptake in the myocardium and the fast liver washout of 99mTc-N-DBODC will allow SPECT images of the left ventricle to be acquired early and with excellent quality.
authors.affiliation: Laboratory of Nuclear Medicine and Nuclear Medicine Section, Department of Radiological Sciences, University of Ferrara, Ferrara, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Cittanti
authors.forename: Licia
authors.initials: L
authors.lastname: Uccelli
authors.forename: Micol
authors.initials: M
authors.lastname: Pasquali
authors.forename: Alessandra
authors.initials: A
authors.lastname: Boschi
authors.forename: Claudia
authors.initials: C
authors.lastname: Flammia
authors.forename: Elisa
authors.initials: E
authors.lastname: Bagatin
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Casali
authors.forename: Michael G
authors.initials: MG
authors.lastname: Stabin
authors.forename: Luciano
authors.initials: L
authors.lastname: Feggi
authors.forename: Melchiore
authors.initials: M
authors.lastname: Giganti
authors.forename: Adriano
authors.initials: A
authors.lastname: Duatti
mesh_terms: D000328:Adult; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009928:Organ Specificity; D009943:Organophosphorus Compounds / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D051598:Whole Body Imaging
chemical_list: C496311:99mTc-N-DBODC5; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals