title: Plasma Epstein-Barr viral load predicting response after chemotherapy for post-transplant lymphoproliferative disease.
abstract: Transplant patients are particularly at risk of developing B post-transplant lymphoproliferative disease (PTLD) related to intensive immunosuppressive treatment to prevent graft rejection. In EBV-positive PTLDs, EBV-DNA can be found in the patients' peripheral blood. Several methods have been described to assess peripheral blood EBV viral load. We report a case of a 13-year-old child who developed EBV-positive PTLD after renal transplantation. We assessed EBV plasma viral load by quantitative PCR and we found that the clearance of EBV-DNA correlated well with response to treatment.
authors.affiliation: Serviço de Hematologia, Hospital do Câncer I, Instituto Nacional do Câncer, Praça Cruz Vermelha, 20 230-130, Rio de Janeiro, Brazil.
authors.forename: Alex Sandro C
authors.initials: AS
authors.lastname: Machado
authors.forename: Alexandre Gustavo
authors.initials: AG
authors.lastname: Apa
authors.forename: Lidia Maria
authors.initials: LM
authors.lastname: Magalhães de Rezende
authors.forename: Nívea Dias
authors.initials: ND
authors.lastname: Amoêdo
authors.forename: Franklin David
authors.initials: FD
authors.lastname: Rumjanek
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Bacchi
authors.forename: Claudete Esteves
authors.initials: CE
authors.lastname: Klumb
mesh_terms: D000293:Adolescent; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000188:drug therapy* / Q000209:etiology; D019562:Viral Load
chemical_list: D004279:DNA, Viral