[Involvement of zinc in taste disturbance occurring during treatment for malignant tumor in the chest and the effects of polaprezinc oral disintegrating tablets (a retrospective study)].
We analyzed the correlation between serum zinc levels and taste disturbance, and between patient backgrounds and serum zinc levels or taste disturbance, and evaluated the effects of polaprezinc oral disintegrating tablets on taste disturbance in 29 patients with lung cancer and one patient with malignant pleural mesothelioma who were receiving chemotherapy. Taste disturbance developed in 11 (36.7%) out of 30 patients. Serum zinc levels significantly correlated with taste disturbance (p=0.0227). Serum zinc levels were significantly lower (p=0.0235) and taste disturbance tended to be more frequent (p=0.0625) in males. Polaprezinc improved taste disturbance in 5 of 8 patients.
Nakata
Yoko
Y
Dept. of Pharmacy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases.
Hirashima
Tomonori
T
Kondou
Yoko
Y
Tokuoka
Yoshie
Y
Imazato
Hitomi
H
Iwata
Kaori
K
Oomori
Yukari
Y
Yamato
Akihiro
A
Shimizu
Saburou
S
Nagao
Sadako
S
Matsui
Kaoru
K
Abe
Noriko
N
D000284:Administration, Oral; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002336:Carnosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage*; D010997:Pleural Neoplasms / Q000097:blood / Q000188:drug therapy; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D013651:Taste Disorders / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy*; D015032:Zinc / Q000097:blood*; D017967:Zinc Compounds / Q000008:administration & dosage
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D017967:Zinc Compounds; C061957:polaprezinc; D002336:Carnosine; D015032:Zinc