title: [Design optimization of endovascular stent by finite element method].
abstract: Stent implantation is now the favorable therapy of coronary heart disease, but the restenosis occurring in association with the currently used stents device has become the main obstacle limiting the further development of stent. To change the expanding behavior of endovascular stents by way of design optimization is considered one of the effective approaches for reducing the damage to the intima of blood vessel and thereby decreasing the in-stent restenosis. So in this paper, the finite element method was used to systematically simulate and analyze the influences of different width of ring supporter and the non-symmetrical design of stent on its transitorily expanding behavior. The results show that among the structure parameters, the width of ring supporter of stent influences its expanded pressure remarkably. When designing the endovascular stent, we make its ring supporter unsymmetrical, i. e., we make the width of ring supporter of stent change degressively from its central part to end part. By this means, the dogboning, which normally happens in the expanding process of the balloon/stent system, can be effectively controlled and the acute vascular injuries can be reduced.
authors.affiliation: School of Materials Sciences and Engineering, Dalian University of Technology, Dalian 116024, China. wangwq@dlut.edu.cn
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Dazhi
authors.initials: D
authors.lastname: Yang
authors.forename: Min
authors.initials: M
authors.lastname: Qi
mesh_terms: D017076:Computer-Aided Design; D023921:Coronary Stenosis / Q000517:prevention & control*; D020342:Finite Element Analysis; D006801:Humans; D011474:Prosthesis Design; D015607:Stents / Q000009:adverse effects