title: Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer.
abstract: The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment.
authors.affiliation: Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. gary.stein@umassmed.edu
authors.forename: Gary S
authors.initials: GS
authors.lastname: Stein
authors.forename: Sayyed K
authors.initials: SK
authors.lastname: Zaidi
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stein
authors.forename: Jane B
authors.initials: JB
authors.lastname: Lian
authors.forename: Andre J
authors.initials: AJ
authors.lastname: van Wijnen
authors.forename: Martin
authors.initials: M
authors.lastname: Montecino
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Young
authors.forename: Amjad
authors.initials: A
authors.lastname: Javed
authors.forename: Jitesh
authors.initials: J
authors.lastname: Pratap
authors.forename: Je-Yong
authors.initials: JY
authors.lastname: Choi
authors.forename: Syed A
authors.initials: SA
authors.lastname: Ali
authors.forename: Sandhya
authors.initials: S
authors.lastname: Pande
authors.forename: Mohammad Q
authors.initials: MQ
authors.lastname: Hassan
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics*; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors