title: Computer-based execution of clinical guidelines: a review.
abstract: OBJECTIVE
  Clinical guidelines are useful tools to standardize and improve health care. The automation of the guideline execution process is a basic step towards its widespread use in medical centres. This paper presents an analysis and a comparison of eight systems that allow the enactment of clinical guidelines in a (semi) automatic fashion.
  
  
  METHODS
  This paper presents a review of the literature (2000-2007) collected from medical databases as well as international conferences in the medical informatics area.
  
  
  RESULTS
  Eight systems containing a guideline execution engine were selected. The language used to represent the guidelines as well as the architecture of these systems were compared. Different aspects have been assessed for each system, such as the integration with external elements or the coordination mechanisms used in the execution of clinical guidelines. Security and terminology issues complement the above study.
  
  
  CONCLUSIONS
  Although these systems could be beneficial for clinicians and patients, it is an ongoing research area, and they are not yet fully implemented and integrated into existing careflow management systems and hence used in daily practice in health care institutions.
authors.affiliation: University Rovira i Virgili, Department of Computer Science and Mathematics, Intelligent Technologies for Advanced Knowledge Acquisition Research Group, iTAKA, Av Països Catalans, 26, 43007 Tarragona, Catalonia, Spain. david.isern@urv.cat
authors.forename: David
authors.initials: D
authors.lastname: Isern
authors.forename: Antonio
authors.initials: A
authors.lastname: Moreno
mesh_terms: D016494:Computer Security; D003201:Computers; D016208:Databases, Factual; D003695:Delivery of Health Care; D006801:Humans; D007802:Language; D008492:Medical Informatics Computing; D017410:Practice Guidelines as Topic / Q000592:standards