title: Dopamine, kidney, and hypertension: studies in dopamine receptor knockout mice.
abstract: Dopamine is important in the pathogenesis of hypertension because of abnormalities in receptor-mediated regulation of renal sodium transport. Dopamine receptors are classified into D(1)-like (D(1), D(5)) and D(2)-like (D(2), D(3), D(4)) subtypes, all of which are expressed in the kidney. Mice deficient in specific dopamine receptors have been generated to provide holistic assessment on the varying physiological roles of each receptor subtype. This review examines recent studies on these mutant mouse models and evaluates the impact of individual dopamine receptor subtypes on blood pressure regulation.
authors.affiliation: Department of Pediatrics, Georgetown University Medical Center, Washington, DC, USA.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.forename: Van Anthony M
authors.initials: VA
authors.lastname: Villar
authors.forename: Ines
authors.initials: I
authors.lastname: Armando
authors.forename: Gilbert M
authors.initials: GM
authors.lastname: Eisner
authors.forename: Robin A
authors.initials: RA
authors.lastname: Felder
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Jose
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D011954:Receptors, Dopamine / Q000235:genetics* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
chemical_list: D011954:Receptors, Dopamine; D043562:Receptors, G-Protein-Coupled; D012964:Sodium; D004298:Dopamine