Sensorineural hearing loss in primary antibody deficiency disorders.
To evaluate the hearing function in patients affected by primary antibody deficiency disorders. Forty-seven patients, 25 of whom were affected by X-linked agammaglobulinemia and 22 of whom were affected by common variable immunodeficiency were evaluated with audiologic tests that included pure tone audiometry, acoustic immittance assessment and auditory brainstem-evoked response. Eighteen patients (38%), 7 with X-linked agammaglobulinemia and 11 with common variable immunodeficiency, showed sensorineural hearing loss, bilateral in 12 and unilateral in 6. Our data underline the high frequency of hearing loss in patients with antibody deficiency and suggest that a systematic audiologic evaluation should be part of the clinical care of these patients.
Berlucchi
Marco
M
Department of Pediatric Otorhinolaringology, Spedali Civili, Brescia, Italy.
Soresina
Annarosa
A
Redaelli De Zinis
Luca O
LO
Valetti
Luisa
L
Valotti
Roberta
R
Lougaris
Vassilios
V
Meini
Antonella
A
Salsi
Daria
D
Nicolai
Piero
P
Plebani
Alessandro
A
D000158:Acoustic Impedance Tests; D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications* / Q000276:immunology; D001301:Audiometry, Pure-Tone; D001402:B-Lymphocytes; D002648:Child; D002675:Child, Preschool; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000276:immunology; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D053632:X-Linked Combined Immunodeficiency Diseases / Q000150:complications* / Q000276:immunology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M