Scope of drug-induced, infectious and allergic esophageal injury.
OBJECTIVE
The most common cause of esophageal injury is gastroesophageal reflux disease, however other less recognized causes may affect the esophagus. In this review we will focus on pill-induced esophageal injury, infections of the esophagus and eosinophilic esophagitis.


RESULTS
Esophageal infections are less frequent since HIV infection has become better controlled with antiviral therapies. The most emergent 'allergic' disease of the esophagus is eosinophilic esophagitis, which has become increasingly recognized in children and adults over the last decade. Eosinophilic esophagitis is a clinicopathologic disorder characterized by a dense esophageal eosinophilia generally occurring in association with upper gastrointestinal symptoms, primarily intermittent dysphagia, and refractory to proton pump inhibitor therapy.


CONCLUSIONS
Drug-induced esophageal injury remains underdiagnosed and should be better recognized.
Geagea
Antoine
A
Department of Gastroenterology, European Georges Pompidou Hospital, Paris, France.
Cellier
Christophe
C
D003141:Communicable Diseases / Q000150:complications; D064420:Drug-Related Side Effects and Adverse Reactions; D004802:Eosinophilia / Q000150:complications; D004941:Esophagitis / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D004947:Esophagus / Q000293:injuries*; D006801:Humans; D006967:Hypersensitivity / Q000150:complications; D013607:Tablets / Q000009:adverse effects
D013607:Tablets