Isoforms of hyaluronidases can be a predictor of a prostate cancer of good prognosis.
BACKGROUND
Hyaluronidases (HAases) are enzymes related to cancer progression. Isoforms of HAases have been described as products of alternative splicing responsible for differences in enzyme activity. The heterogeneity of HAase expression has been identified in tumors and could be related to the differences in their biological behavior.


METHODS
Thirty-seven patients subjected to radical prostatectomy for prostate cancer were divided into 2 groups for the analyses: Low (< or =6-18) and high (> or =7-19) Gleason score and tumor behavior; recurrence 15 and nonrecurrence 22, mean follow-up 52.6 months.


CONCLUSIONS
A profile of HAase related to low Gleason score and non-tumor recurrence was characterized by expression of HYAL3-v1, HYAL1-v3, and HYAL3-v2. More studies should be made in order to confirm with larger series.
de Sá
Vanessa K
VK
Laboratory of Medical Investigation-LIM55 Medical School, Urology Department, São Paulo University, São Paulo, Brazil.
Canavez
Flávio C
FC
Silva
Iran A
IA
Srougi
Miguel
M
Leite
Katia R M
KR
D000368:Aged; D017398:Alternative Splicing; D014408:Biomarkers, Tumor; D017931:DNA Primers / Q000737:chemistry; D018450:Disease Progression; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000096:biosynthesis / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D020033:Protein Isoforms; D012008:Recurrence; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D017931:DNA Primers; D020033:Protein Isoforms; D006821:Hyaluronoglucosaminidase