title: Radiation dose to surgical staff from positron-emitter-based localization and radiosurgery of tumors.
abstract: Surgical tissue characterization based on radiotracer uptake has become much more common in recent years, particularly due to the advent of the sentinel lymph node biopsy technique. Radiolabeled pharmaceuticals are used with hand-held gamma-sensitive probes, which are capable of localizing small tumors and lymph nodes that are first identified via scintigraphy. The radiation safety of such radioguided procedures, which typically employ 99mTc, has been well established. Now, with the emergence of 18F-fluorodeoxyglucose (18FDG) as a widely used tracer for PET imaging of cancer patients, there is increasing interest in the possibility of utilizing 18FDG for intraoperative tumor detection. First, though, the exposure to operating room personnel must be shown to be at a safe level. Due to the short half-life of 18F, the exposure rate will vary significantly with the start time post-injection as well as the duration of the procedure. The aim of this investigation is to determine empirically an exposure rate equation that can be integrated to estimate the exposure to a surgeon and assistants, from patients injected with 18FDG, over an arbitrarily chosen time interval. The study was conducted by measuring the radiation exposure rate from hospital in-patients receiving 18FDG-PET scans at various times from one to seven hours post injection; the empirical equation was determined from the plot of exposure rate vs. time for all patients. The resulting effective dose equivalent for the surgeon for typical values of injected activity, delay time and procedure duration was approximately 60 microSv.
authors.affiliation: Department of Molecular & Medical Pharmacology, UCLA School of Medicine, B2-049B CHS, Box 956948, 650 Charles Young Drive S., Los Angeles, CA 90095-6948, USA. eheckathorne@mednet.ucla.edu
authors.forename: Elena
authors.initials: E
authors.lastname: Heckathorne
authors.forename: Colin
authors.initials: C
authors.lastname: Dimock
authors.forename: Magnus
authors.initials: M
authors.lastname: Dahlbom
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008297:Male; D008505:Medical Staff, Hospital; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery; D016273:Occupational Exposure / Q000032:analysis; D049268:Positron-Emission Tomography; D011829:Radiation Dosage; D011835:Radiation Protection; D019275:Radiopharmaceuticals; D016634:Radiosurgery / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18