title: Odorant design based on the carbon/silicon switch strategy.
abstract: Silicon chemistry has been demonstrated to be a novel source of chemical diversity in odorant design. The carbon/silicon switch strategy, i.e., sila-replacement in known odorants, is one of the methods currently used for the development of silicon-based odorants. Examples resulting from this strategy are sila-coranol, sila-dimetol, sila-linalool, sila-muguetalcohol, sila-majantol, sila-hydratropyl acetate, sila-bourgeonal, sila-lilial, disila-versalide, and disila-okoumal.
authors.affiliation: Universität Würzburg, Institut für Anorganische Chemie, Am Hubland, D-97074 Würzburg. r.tacke@mail.uni-wuerzburg.de
authors.forename: Reinhold
authors.initials: R
authors.lastname: Tacke
authors.forename: Stefan
authors.initials: S
authors.lastname: Metz
mesh_terms: D000818:Animals; D001665:Binding Sites; D002244:Carbon / Q000737:chemistry*; D007313:Insecta; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009812:Odorants / Q000032:analysis*; D010476:Perfume / Q000138:chemical synthesis* / Q000737:chemistry; D018035:Receptors, Odorant / Q000378:metabolism; D012684:Sensory Thresholds / Q000502:physiology; D012825:Silicon / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D008024:Ligands; D010476:Perfume; D018035:Receptors, Odorant; D002244:Carbon; D012825:Silicon