Molecular polymorphism of Abeta in Alzheimer's disease.
Alzheimer's disease is defined pathologically by the presence of senile plaques, which consist primarily of extracellular aggregates of fibrillar Abeta peptide, and neurofibrillary tangles, which are abnormal, intracellular bundles of fibrillar tau protein. The advent of amyloid binding agents as diagnostic imaging probes for Alzheimer's disease (AD) has made it imperative to understand at a molecular and disease level what these ligands are reporting. In addition to improving the accuracy of diagnosis, we argue that these selective ligands can serve as probes for molecular polymorphisms that may govern the pathogenicity of abnormal protein aggregates.
Levine
Harry
H
Department of Molecular and Cellular Biochemistry, Chandler School of Medicine and the Center on Aging, University of Kentucky, Lexington, KY, USA. hlevine@email.uky.edu
Walker
Lary C
LC
D000544:Alzheimer Disease / Q000175:diagnosis* / Q000378:metabolism* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D000814:Aniline Compounds; D000818:Animals; D052160:Benzothiazoles; D001665:Binding Sites / Q000502:physiology; D001667:Binding, Competitive / Q000502:physiology; D004396:Coloring Agents; D003224:Congo Red; D003952:Diagnostic Imaging / Q000379:methods; D004195:Disease Models, Animal; D006801:Humans; D008024:Ligands; D015335:Molecular Probes / Q000378:metabolism; D057089:Pathology, Molecular / Q000379:methods*; D058225:Plaque, Amyloid / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D011237:Predictive Value of Tests; D020033:Protein Isoforms / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D013844:Thiazoles
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D052160:Benzothiazoles; D004396:Coloring Agents; D008024:Ligands; D015335:Molecular Probes; D020033:Protein Isoforms; D013844:Thiazoles; C009462:thioflavin T; D003224:Congo Red