Enabling continuous-flow chemistry in microstructured devices for pharmaceutical and fine-chemical production.
Microstructured devices offer unique transport capabilities for rapid mixing, enhanced heat and mass transfer and can handle small amounts of dangerous or unstable materials. The integration of reaction kinetics into fluid dynamics and transport phenomena is essential for successful application from process design in laboratory to chemical production. Strategies to implement production campaigns up to tons of pharmaceutical chemicals are discussed, based on Lonza projects.
Kockmann
Norbert
N
R&D Exclusive Synthesis, Process Optimization, Lonza AG, Visp, Switzerland. norbert.kockmann@lonza.com
Gottsponer
Michael
M
Zimmermann
Bertin
B
Roberge
Dominique M
DM
D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D007700:Kinetics; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*
D004364:Pharmaceutical Preparations