title: In vivo antiplasmodial activity of 11(13)-dehydroivaxillin from Carpesium ceruum.
abstract: The whole plants of Carpesium genus are used in traditional medicine as anti-pyretic, analgesic and vermifugic, including a topical application for sores and inflammation. A previous study on Carpesium genus suggested that the antiplasmodial activity against Plasmodium falciparum was due to the existence of 11(13)- dehydroivaxillin (DDV) from EtOAc extracts of C. ceruum (Compositae). Here, the antimalarial activity of DDV was evaluated against Plasmodium berghei in mice. The LD(50) of the compound was determined as 51.2 mg/kg, while doses of 124 mg/kg and above were found to be lethal to mice. DDV (2, 5, 10 mg/kg/day) exhibited a significant blood schizontocidal activity in 4-day early infection, repository evaluation and in an established infection with a significant mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. DDV possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.
authors.affiliation: Department of Environmental Science, Kon Kuk University, Seoul 143-701, South Korea.
authors.forename: Jong-Jin
authors.initials: JJ
authors.lastname: Kim
authors.forename: Ill-Min
authors.initials: IM
authors.lastname: Chung
authors.forename: Jae-Chul
authors.initials: JC
authors.lastname: Jung
authors.forename: Min-Young
authors.initials: MY
authors.lastname: Kim
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D008288:Malaria / Q000188:drug therapy; D020714:Maximum Tolerated Dose; D051379:Mice; D010936:Plant Extracts; D010946:Plants, Medicinal; D010962:Plasmodium berghei / Q000187:drug effects; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D015996:Survival Rate
chemical_list: C539173:11(13)-dehydroivaxillin; D000962:Antimalarials; D010936:Plant Extracts; D012717:Sesquiterpenes