Anti-Toxoplasma gondii RH strain activity of herbal extracts used in traditional medicine.
Methanolic extracts of 15 traditional medicines used to treat Toxoplasma gondii were tested in vitro for their anti-T. gondii activity and cytotoxicity. The median effective concentration (EC(50)) values for the herbal extracts ranged from 0.11mg/mL to 2.28mg/mL. Significant anti-T. gondii RH strain activity was observed with Zingiber officinale extracts (EC(50)=0.18mg/mL), which displayed a highly selective toxicity (selectivity=10.1). Sophora flavescens Aiton extracts also showed high anti-T. gondii activity (EC(50)=0.20mg/mL) and a high selective toxicity (4.6). This indicates that Z. officinale and S. flavescens Aiton extracts may be sources of new anti-T. gondii compounds.
Choi
Kyung-Min
KM
Ecodigm Co., Ltd., Yuseong-gu, Daejeon, South Korea.
Gang
Jingu
J
Yun
Jisoo
J
D000818:Animals; D006367:HeLa Cells; D006801:Humans; D007723:Korea; D008519:Medicine, Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D021261:Parasitic Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry*; D029909:Sophora / Q000737:chemistry*; D014122:Toxoplasma / Q000187:drug effects*; D019862:Zingiberales / Q000737:chemistry
D010936:Plant Extracts