title: Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1).
abstract: This study reports the identification and Hits to Leads optimization of inhibitors of coactivator associated arginine methyltransferase (CARM1). Compound 7b is a potent, selective inhibitor of CARM1.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research and Development, Princeton, NJ 08543, USA. ashok.purandare@bms.com
authors.forename: Ashok V
authors.initials: AV
authors.lastname: Purandare
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.forename: Tram
authors.initials: T
authors.lastname: Huynh
authors.forename: Suhong
authors.initials: S
authors.lastname: Pang
authors.forename: Jieping
authors.initials: J
authors.lastname: Geng
authors.forename: Wayne
authors.initials: W
authors.lastname: Vaccaro
authors.forename: Michael A
authors.initials: MA
authors.lastname: Poss
authors.forename: Jonathan
authors.initials: J
authors.lastname: Oconnell
authors.forename: Kimberly
authors.initials: K
authors.lastname: Nowak
authors.forename: Lata
authors.initials: L
authors.lastname: Jayaraman
mesh_terms: D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D011484:Protein-Arginine N-Methyltransferases / Q000037:antagonists & inhibitors*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D011720:Pyrazoles; D011484:Protein-Arginine N-Methyltransferases; C119966:coactivator-associated arginine methyltransferase 1