Genetic predictors of depressive symptoms in cardiac patients.
Numerous studies suggest that the prevalence of depression is greater among cardiac patients than in the general population. However, little attention has been paid to the possibility of genetic contributions to depressive symptoms in cardiac patients. We conducted a candidate gene study focusing on genes related to inflammation, platelet aggregation, endothelial function and omega-3 fatty acid metabolism as predictors of depressive symptoms among 977 participants with established cardiovascular disease. Results suggested that genetic variation related to endothelial dysfunction is predictive of depressive symptoms and that endothelial dysfunction may be a novel mechanism contributing to depressive symptoms among cardiac patients.
McCaffery
Jeanne M
JM
Weight Control and Diabetes Research Center, Brown Medical School, Providence, RI 02903, USA. jeanne_mccaffery@brown.edu
Duan
Qing Ling
QL
Frasure-Smith
Nancy
N
Barhdadi
Amina
A
Lespérance
Francois
F
Théroux
Pierre
P
Rouleau
Guy A
GA
Dubé
Marie-Pierre
MP
D000483:Alleles; D002170:Canada / Q000453:epidemiology; D003863:Depression / Q000150:complications / Q000235:genetics*; D042783:Endothelial Cells / Q000473:pathology; D015525:Fatty Acids, Omega-3 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005602:France / Q000208:ethnology; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006331:Heart Diseases / Q000453:epidemiology / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D007438:Introns; D016014:Linear Models; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics; D016017:Odds Ratio; D010974:Platelet Aggregation / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D015995:Prevalence; D014841:von Willebrand Factor / Q000235:genetics
D015525:Fatty Acids, Omega-3; D005819:Genetic Markers; D014841:von Willebrand Factor