Undifferentiated sarcoma of the maxillary sinus: report of a rare case in an adult.
A 51-year-old man complained of left facial swelling and recurrent nasal bleeding. A giant solid tumor in the left maxillary sinus was detected on head CT and MRI, and this tumor was destroying the maxilla and extending into the orbit, pterygoid muscle and posterior paranasal sinuses. The resected specimen consisted of spindle cells containing necrotic material. Histological examination revealed immature tumor cells, and immunohistological study of the tumor showed staining was only positive for vimentin. We accordingly diagnosed undifferentiated sarcoma in the maxillary sinus. Combination chemotherapy with vincristine, doxorubicin, cyclophosphamide/ifosfamide with mesna and etoposide was administered; however, the tumor was unresponsive and the patient died after around 3 months.
Hosokawa
Seiji
S
Department of Otolaryngology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan. seijih@hama-med.ac.jp
Takebayashi
Satoru
S
Mineta
Hiroyuki
H
Suzuki
Kazuya
K
Baba
Satoshi
S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D015080:Mesna / Q000008:administration & dosage; D008875:Middle Aged; D020011:Protective Agents / Q000008:administration & dosage; D012509:Sarcoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D014750:Vincristine / Q000008:administration & dosage
D020011:Protective Agents; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D015080:Mesna; D007069:Ifosfamide