Sesquilignans and dilignans from Campylotropis hirtella (Franch.) Schindl.
A new sesquilignan, erythro-Guaiacylglycerol-beta-O-4'-(5')-methoxylariciresinol, together with six known compounds including three sesquilignans and three dilignans, have been isolated from Campylotropis hirtella (Franch.) Schindl. that was used as traditional Chinese medicine for treatment of benign prostate hyperplasia. All these known compounds were found for the first time from the family leguminosae. The structure of the new compound and its relative configurations were elucidated on the basis of detailed spectroscopic analysis (NMR and MS). These compounds showed no obvious inhibition effect on prostate specific antigen secretion in LNCaP cells by ELISA method.
Han
Hui-Ying
HY
College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110015, China.
Liu
Hong-Wei
HW
Wang
Nai-Li
NL
Yao
Xin-Sheng
XS
D045744:Cell Line, Tumor; D004797:Enzyme-Linked Immunosorbent Assay; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology
D017705:Lignans; C534274:erythro-guaiacylglycerol-beta-O-4'-(5')-methoxylariciresinol; D017430:Prostate-Specific Antigen