title: The effects of hyperbaric oxygen therapy on colonic anastomosis in rats with peritonitis.
abstract: The aim of this study is to investigate the healing effect of hyperbaric oxygen (HBO) on colonic anastomoses in the presence of experimentally induced peritonitis. Thirty-two rats were allocated randomly into short-term anastomosis (STA), short-term anastomosis + HBO treatment (STA+HBO), long-term anastomosis (LTA), and long-term anastomosis + HBO (LTA+HBO) treatment groups. The STA and LTA groups were administered fluid resuscitation and antibiotics for 3 and 7 days, respectively, whereas the HBO treatment groups received additional HBO therapy for 3 and 7 days, respectively. The rats were reoperated on the third and the seventh days of anostomoses for evaluation. The bursting pressures in STA+HBO and LTA+HBO therapy groups were significantly higher than those in groups with anastomoses alone (p < .001 and p < .01). HBO therapy did not affect the fibrotic index neither in STA nor in LTA groups (p > .05 for both); however, it was significantly higher in LTA+HBO group than that in STA+HBO group (p < .05). The hydroxyproline level was significantly higher in LTA group than in STA group (p < .05), yet HBO therapy did not affect the hydroxyproline levels in STA or LTA groups (p > .05 for both). It is concluded that hyperbaric oxygen treatment has positive effects on colonic anastomotic healing in case of peritonitis.
authors.affiliation: General Surgery, Haydarpasa Training Hospital, Istanbul, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Sucullu
authors.forename: Huseyin
authors.initials: H
authors.lastname: Sinan
authors.forename: Ali Ilker
authors.initials: AI
authors.lastname: Filiz
authors.forename: Senol
authors.initials: S
authors.lastname: Yildiz
authors.forename: Ergun
authors.initials: E
authors.lastname: Yucel
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Kurt
authors.forename: Mehmet Levhi
authors.initials: ML
authors.lastname: Akin
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D003106:Colon / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D005260:Female; D005355:Fibrosis / Q000473:pathology; D006909:Hydroxyproline / Q000378:metabolism; D006931:Hyperbaric Oxygenation; D008297:Male; D010538:Peritonitis / Q000473:pathology*; D011183:Postoperative Complications / Q000517:prevention & control; D011312:Pressure; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013718:Tensile Strength; D013997:Time Factors; D014945:Wound Healing
chemical_list: D006909:Hydroxyproline