title: Cadinane sesquiterpenes from the leaves of Eupatorium adenophorum.
abstract: Four new cadinane sesquiterpenes (1- 4), including a dimeric cadinane derivative (2) and a peroxide cadinane analogue (3), have been isolated from the leaves of Eupatorium adenophorum. Their structures including absolute configurations were determined on the basis of spectroscopic data interpretation and single-crystal X-ray crystallography. Compound 4 showed in vitro cytotoxicity against the HCT-8, Bel-7402, and A2780 cancer cell lines.
authors.affiliation: Department of Chemistry, Beijing Normal University, Beijing 100875, People's Republic of China. helan1961@yahoo.com.cn
authors.forename: Lan
authors.initials: L
authors.lastname: He
authors.forename: Jing
authors.initials: J
authors.lastname: Hou
authors.forename: Maoluo
authors.initials: M
authors.lastname: Gan
authors.forename: Jiangong
authors.initials: J
authors.lastname: Shi
authors.forename: Suchada
authors.initials: S
authors.lastname: Chantrapromma
authors.forename: Hoong-Kun
authors.initials: HK
authors.lastname: Fun
authors.forename: Ian D
authors.initials: ID
authors.lastname: Williams
authors.forename: Herman H-Y
authors.initials: HH
authors.lastname: Sung
mesh_terms: D036603:Ageratina / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C508039:cadinane