Kounis syndrome secondary to amoxicillin/clavulanic acid use in a child.
The concurrence of acute coronary syndromes with allergic or hypersensitivity as well as with anaphylactic or anaphylactoid reactions is increasingly encountered in clinical practice and there are several reports associating mast cell activation with acute cardiovascular events in adults. It was first described by Kounis as "allergic angina syndrome" progressing to "allergic myocardial infarction". The main mechanism proposed is the vasospasm of coronary arteries. This condition has not been described in childhood. We present a 13-year-old boy, admitted to our hospital with thoracic pain, 30 min after the ingestion of an oral dose of 500 mg of amoxicillin/clavulanic acid.
Biteker
Murat
M
Duran
Nilüfer Ekşi
NE
Biteker
Funda Sungur
FS
Ertürk
Emre
E
Aykan
Ahmet Cağri
AC
Civan
Hasret Ayyildiz
HA
Ozkan
Mehmet
M
D054058:Acute Coronary Syndrome / Q000139:chemically induced / Q000175:diagnosis* / Q000503:physiopathology; D000293:Adolescent; D000658:Amoxicillin / Q000008:administration & dosage / Q000009:adverse effects*; D019818:Clavulanic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D004452:Echocardiography; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000175:diagnosis* / Q000503:physiopathology
D019818:Clavulanic Acid; D000658:Amoxicillin