title: Serum alpha-fetoprotein predicts virologic response to hepatitis C treatment in HIV coinfected patients.
abstract: We explored the link between serum alpha-fetoprotein levels and virologic response in 383 HIV-hepatitis C virus coinfected patients. A low alpha-fetoprotein level (<5.0 ng/ml) was an independent predictor of sustained virologic response (odds ratio = 1.83; 95% confidence interval 1.05-3.20). Serum alpha-fetoprotein measurement should be integrated in the pretreatment assessment of prognostic factors of a virologic response.
authors.affiliation: UPMC-Paris6, UMR-S707, INSERM, UMR-S707, Saint-Antoine Hospital, Assistance Publique Hôpitaux de Paris, France. carrat@u707.jussieu.fr
authors.forename: Fabrice
authors.initials: F
authors.lastname: Carrat
authors.forename: Pierre
authors.initials: P
authors.lastname: Bedossa
authors.forename: Françoise
authors.initials: F
authors.lastname: Lunel-Fabiani
authors.forename: Patrice
authors.initials: P
authors.lastname: Morand
authors.forename: Gilles
authors.initials: G
authors.lastname: Pialoux
authors.forename: Lionel
authors.initials: L
authors.lastname: Piroth
authors.forename: Dominique
authors.initials: D
authors.lastname: Salmon-Céron
authors.forename: Firouzé
authors.initials: F
authors.lastname: Bani-Sadr
authors.forename: Christian
authors.initials: C
authors.lastname: Perronne
authors.forename: Patrice
authors.initials: P
authors.lastname: Cacoub
authors.forename: Stanislas
authors.initials: S
authors.lastname: Pol
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D008297:Male; D011092:Polyethylene Glycols; D011994:Recombinant Proteins; D012254:Ribavirin / Q000627:therapeutic use; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D000998:Antiviral Agents; D015415:Biomarkers; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D000509:alpha-Fetoproteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C417083:peginterferon alfa-2b