Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Abeta-peptide production inhibitors.
Laras
Y
Y
Laboratoire de Chimie Biomoléculaire, IBDM-UMR-6216-CNRS, Faculté des Sciences Luminy, Université de Méditerranée, Marseille cedex 9, France.
Pietrancosta
N
N
Tomita
T
T
Iwatsubo
T
T
Kraus
J L
JL
D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D001381:Azepines / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D002460:Cell Line; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010455:Peptides / Q000378:metabolism*; D010880:Piperidines / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D016229:Amyloid beta-Peptides; D001381:Azepines; D010455:Peptides; D010880:Piperidines; D013141:Spiro Compounds; D001554:Benzene