Preparation of a library of unsymmetrical ureas based on 8-azabicyclo[3.2.1]octane scaffold.
This paper reports the preparation of a library of unsymmetrical ureas based on 8-azabicyclo[3.2.1]octane scaffold. The reported synthetic route uses nortropane-8-carbonyl chlorides as key intermediates that, when treated with a slight excess of amine, give the corresponding ureas in high yield (129 examples).
Agarkov
Anton
A
Chemical Biology Program, Department of Pharmacology and Toxicology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555-0650, USA.
Gilbertson
Scott R
SR
D000588:Amines / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry; D008956:Models, Chemical; D008970:Molecular Weight; D009662:Nortropanes / Q000737:chemistry; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D014326:Tropanes / Q000737:chemistry*; D014508:Urea / Q000138:chemical synthesis*
D000588:Amines; D006843:Hydrocarbons, Chlorinated; D009662:Nortropanes; D012997:Solvents; D014326:Tropanes; D014508:Urea