title: Regulation of the RelA (p65) transactivation domain.
abstract: The RelA (p65) NF-kappaB (nuclear factor kappaB) subunit contains an extremely active C-terminal transcriptional activation domain, required for its cellular function. In the present article, we review our knowledge of this domain, its modifications and its known interacting proteins. Moreover, we discuss how analysis of its evolutionary conservation reveals distinct subdomains and conserved residues that might give insights into its regulation and function.
authors.affiliation: College of Life Sciences, Wellcome Centre for Gene Regulation and Expression, MSI/WTB Complex, Dow Street, University of Dundee, Dundee, Scotland, UK.
authors.forename: John M
authors.initials: JM
authors.lastname: O'Shea
authors.forename: Neil D
authors.initials: ND
authors.lastname: Perkins
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D008025:Ligases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D011485:Protein Binding; D015533:Transcriptional Activation / Q000235:genetics*
chemical_list: D008025:Ligases; C028812:guanosine 3',5'-polyphosphate synthetases