Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns.
OBJECTIVE
To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS).


METHODS
A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed.


RESULTS
In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses.


CONCLUSIONS
CD14 and TLR4 showed an association with AS in the Finns only.
Pointon
Jennifer J
JJ
NIHR OxfordMusculoskeletal Biomedical Research Unit and BotnarResearch Centre, Oxford, UK. jennyp@well.ox.ac.uk
Chapman
Kay
K
Harvey
David
D
Sims
Anne-Marie
AM
Bradbury
Linda
L
Laiho
Kari
K
Kauppi
Markku
M
Kaarela
Kalevi
K
Tuomilehto
Jaakko
J
Brown
Matthew A
MA
Wordsworth
B Paul
BP
D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005387:Finland; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013167:Spondylitis, Ankylosing / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D006113:United Kingdom
D018950:Lipopolysaccharide Receptors; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4