Memory health clinics-a first step to prevention.
A few years ago at the European Alzheimer's Disease Consortium-Alzheimer's Disease Cooperative Study meeting in Geneva we discussed with Leon Thal the possibility of building large multi-domain primary preventive international trials for Alzheimer's disease (AD) both in North America and in the European Union. AD is a multifactorial phenomenon, and we will be more likely to succeed in preventive trials if we build a strategy using all potential protective factors to have the most potential effect instead of a simple and unique intervention. Leon Thal suggested that this could have a much bigger impact than all the drugs we might ever hope to develop. The main objective of this article is to present the rationale for multi-domain preventive approaches.
Vellas
Bruno
B
Department of Internal Medicine and Clinical Gerontology, Gerontopole, Toulouse Université Hospital, CHU La Grave-Casselardit, Toulouse, France; Inserm U 558, Toulouse, France. vellas.b@chu-toulouse.fr
Gillette-Guyonnet
Sophie
S
Andrieu
Sandrine
S
D000544:Alzheimer Disease / Q000150:complications / Q000517:prevention & control*; D000554:Ambulatory Care Facilities; D002986:Clinical Trials as Topic; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D008569:Memory Disorders / Q000209:etiology / Q000517:prevention & control*; D015337:Multicenter Studies as Topic