title: [A case of brain metastasis from advanced ovarian clear-cell carcinoma during maintenance chemotherapy with irinotecan+cisplatin].
abstract: Clear-cell carcinoma of the ovary is a highly malignant neoplasm. Survival of patients in the advanced stage is poor, and the best treatment is not clear. We report here a case of a 57-year-old woman who had Stage IIIb advanced clearcell carcinoma of the ovary. We performed abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic lympho adenectomy and partial omentectomy. After the operation she was placed on induction and maintenance chemotherapy with a combination of irinotecan(CPT-11)(60 mg/m2, day 1, 15)plus cisplatin(CDDP)(60 mg/m2, day 1). Four years after surgery, a metastatic tumor was found in the brain. Considering the poor prognosis of clear-cell carcinoma, this regimen is thought to be effective for advanced clear-cell carcinoma of the ovary. It is important to check brain metastases under maintenance chemotherapy.
authors.affiliation: Dept. of Obstetrics and Gynecology, Kasukabe Municipal General Hospital.
authors.forename: Masashi
authors.initials: M
authors.lastname: Takami
authors.forename: Eisuke
authors.initials: E
authors.lastname: Kita
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kuwana
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ohta
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Toshirou
authors.initials: T
authors.lastname: Takimoto
authors.forename: Go
authors.initials: G
authors.lastname: Ichikawa
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D000077146:Irinotecan; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D011859:Radiography
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin