title: Refraction-based 2D, 2.5D and 3D medical imaging: stepping forward to a clinical trial.
abstract: An attempt at refraction-based 2D, 2.5D and 3D X-ray imaging of articular cartilage and breast carcinoma is reported. We are developing very high contrast X-ray 2D imaging with XDFI (X-ray dark-field imaging), X-ray CT whose data are acquired by DEI (diffraction-enhanced imaging) and tomosynthesis due to refraction contrast. 2D and 2.5D images were taken with nuclear plates or with X-ray films. Microcalcification of breast cancer and articular cartilage are clearly visible. 3D data were taken with an X-ray sensitive CCD camera. The 3D image was successfully reconstructed by the use of an algorithm newly made by our group. This shows a distinctive internal structure of a ductus lactiferi (milk duct) that contains inner wall, intraductal carcinoma and multifocal calcification in the necrotic core of the continuous DCIS (ductal carcinoma in situ). Furthermore consideration of clinical applications of these contrasts made us to try tomosynthesis. This attempt was satisfactory from the view point of articular cartilage image quality and the skin radiation dose.
authors.affiliation: Tokyo University of Science, Research Institute for Science and Technology, Noda, Chiba 278-8510, Japan. msm-ando@rs.noda.tus.ac.jp
authors.forename: Masami
authors.initials: M
authors.lastname: Ando
authors.forename: Hiroko
authors.initials: H
authors.lastname: Bando
authors.forename: Tokiko
authors.initials: T
authors.lastname: Endo
authors.forename: Shu
authors.initials: S
authors.lastname: Ichihara
authors.forename: Eiko
authors.initials: E
authors.lastname: Hashimoto
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Hyodo
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kunisada
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Anton
authors.initials: A
authors.lastname: Maksimenko
authors.forename: Kensaku
authors.initials: K
authors.lastname: Mori
authors.forename: Daisuke
authors.initials: D
authors.lastname: Shimao
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yuasa
authors.forename: Ei
authors.initials: E
authors.lastname: Ueno
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D002358:Cartilage, Articular / Q000000981:diagnostic imaging*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D012031:Refractometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014056:Tomography, X-Ray / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*