Fatal methanol intoxication with different survival times--morphological findings and postmortem methanol distribution.
Three corresponding cases of fatal methanol intoxication with different survival times were investigated ante-mortem and postmortem. Ante-mortem serum methanol concentrations were determined during treatment in hospital for 4 days. Furthermore, postmortem distribution of methanol in various tissues and fluids was measured after autopsy. Morphological and toxicological findings are discussed based on the literature. The morphological findings correlated with the different survival times. The results of the toxicological analyses were partly in keeping with previously published data. Interestingly, very high methanol levels were determined in brain with very low concentrations in femoral venous blood. These results may have implications for postmortem toxicological analysis, brain death diagnosis and organ explanation for transplantation.
Andresen
H
H
Institute of Legal Medicine, University of Hamburg, Germany. h.andresen@uke.uni-hamburg.de
Schmoldt
H
H
Matschke
J
J
Flachskampf
F A
FA
Turk
E E
EE
D000328:Adult; D001646:Bile / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002849:Chromatography, Gas; D053593:Forensic Toxicology; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D000432:Methanol / Q000032:analysis / Q000493:pharmacokinetics* / Q000506:poisoning*; D011180:Postmortem Changes; D012997:Solvents / Q000032:analysis / Q000493:pharmacokinetics* / Q000506:poisoning*; D013582:Synovial Fluid / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution; D014822:Vitreous Body / Q000378:metabolism
D012997:Solvents; D000432:Methanol