[The role of mitochondrial permeability transition pore in physiology and pathology of the cell].
Mitochondrial megachannel, a multiprotein complex, is localized in close contacts of the outer and the inner mitochondrial membranes. It plays important role in many aspects of cell physiology and its opening can have different consequences. This review summarizes the present knowledge about structure and function of the megachannel in the cell.
Wieckowski
Mariusz R
MR
Zakład Biochemii, Instytut Biologii Doświadczalnej PAN im. Marcelego Nenckiego, Warszawa. m.wieckowski@nencki.gov.pl
D000818:Animals; D002463:Cell Membrane Permeability / Q000502:physiology; D002468:Cell Physiological Phenomena; D002477:Cells / Q000473:pathology*; D006801:Humans; D008928:Mitochondria / Q000473:pathology* / Q000502:physiology*; D050994:Voltage-Dependent Anion Channels / Q000502:physiology*
D050994:Voltage-Dependent Anion Channels