title: Reduced immunoreactivity of tyrosine hydroxylase in the hypothalamic paraventricular nucleus of the seizure sensitive gerbil.
abstract: We compared the immunoreactivity and numbers of tyrosine hydroxylase (TH) immunoreactive neurons and neuropil in the paraventricular nucleus (PVN) of the hypothalamus between the seizure sensitive (SS) and seizure resistant (SR) gerbils. The distributional pattern of TH immunoreactivity was similar in both groups: TH immunoreactivity was seen mainly in magnocellular neurons of the PVN. However, total TH immunoreactivity in the neurons and neuropil in the SS gerbils was significantly lower than that in the SR gerbils. In addition, the number of TH immunoreactive neurons in the SS gerbils was also much lower than those in the SR gerbils. These results indicate that SS gerbils have a low TH immunoreactivity in the hypothalamic PVN compared with that in SR gerbils.
authors.affiliation: Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, South Korea.
authors.forename: Choong Hyun
authors.initials: CH
authors.lastname: Lee
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Choi
authors.forename: Dae Won
authors.initials: DW
authors.lastname: Chung
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Yeo Sung
authors.initials: YS
authors.lastname: Yoon
authors.forename: Moo-Ho
authors.initials: MH
authors.lastname: Won
authors.forename: In Se
authors.initials: IS
authors.lastname: Lee
mesh_terms: D000818:Animals; D004198:Disease Susceptibility; D005849:Gerbillinae / Q000378:metabolism*; D006861:Hydrogen Peroxide; D007106:Immune Sera / Q000276:immunology / Q000378:metabolism; D009474:Neurons / Q000276:immunology* / Q000378:metabolism; D010286:Paraventricular Hypothalamic Nucleus / Q000201:enzymology*; D012640:Seizures / Q000235:genetics / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000276:immunology* / Q000378:metabolism
chemical_list: D007106:Immune Sera; D006861:Hydrogen Peroxide; D014446:Tyrosine 3-Monooxygenase