[Importance of the post-prandial glycemia in the management of type 2 diabetes].
Cardiovascular disease is the main cause of mortality in diabetic patients. The risk of cardiovascular disease occurs at a lower glycemic level compared to microvascular complications. Post-prandial hyperglycemia seems to play a major role in the development of atherosclerotic lesions. In this article we review the evidence regarding the prognostic value of post-challenge hyperglycaemia relative to the risk of cardiovascular disease, explore the physio-pathologic mechanisms responsible for the negative effects of post-prandial hyperglycaemia and detail the benefits of treatment aimed at controlling post-prandial glycaemia.
Raguso
C A
CA
Service d'endocrinologie, diabétologie et nutrition, HUG, 1211 Genève 14. comasia.raguso@hcuge.ch
Helary
C
C
Philippe
J
J
D002318:Cardiovascular Diseases / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology*; D019518:Postprandial Period; D011379:Prognosis