Cellular uptake and activity of rufloxacin in different cell types and professional phagocytic cells.
The penetration of the new quinolene rufloxacin into human professional phagocytic cells and different cell types was determined. The intracellular distribution was demonstrated in all cells studied. At 4 degrees C the transport of rufloxacin was reduced. An intracellular dose-dependent activity was demonstrated for rufloxacin in monocytes and granulocytes infected with E. coli and S. aureus. In all the experiments rufloxacin was able to eliminate all intracellular bacteria.
Bonina
L
L
Microbiology Institute, Medical School, University of Messina, Messina, Italy.
Arena
A
A
Cesana
M
M
Costa
G B
GB
Mastroeni
F
F
Carbone
M
M