Effects of mild whole body hyperthermia on graded focal ischaemia-reperfusion in a rat stroke model.
The influence of body temperature on focal cerebral ischaemia-reperfusion was investigated by using a well established rat stroke model. Three different degrees of ischaemia were created in the cerebral cortex of the right middle cerebral artery territory by varying the duration of clamping of the bilateral common carotid arteries and the right middle cerebral artery with full reperfusion. Mild hyperthermic (body temperature 38-39 degrees C) influence during ischaemia significantly enhanced the severity of infarction in mild (30 min) ischaemia, mean infarct volume was 78% greater than normothermic (body temperature 36.5-37.5 degrees C) group (P < 0.001); and in moderate (60 min) ischaemia, mean infarct volume was 23% greater than in the normothermic group (P < 0.05); but no difference between the two groups was observed in severe (90 min) ischaemia. Our data suggest that mild whole body hyperthermia during focal ischaemia-reperfusion has a detrimental effect on the infarct volume only in mild and moderate ischaemia in this model.
Yip
P K
PK
Department of Neurology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan 100.
Koh
A T
AT
Lin
C T
CT
Chen
R C
RC