Fungal infections after lung transplantation.
Lung transplantation (LT) is now considered to be the standard therapeutic intervention in some patients with end-stage pulmonary disease. Infectious complications after LT are relatively common due to the aggressive immunosuppression used in these receptors and local host factors derived from this type of transplant. The incidence of fungal infections after LT ranges up to 30%. However, the incidence of invasive mycoses has declined over the past decade. These mycoses are associated with high overall mortality rates despite increase of the antifungal armamentarium in the last years. Candida and Aspergillus spp produce most of these infections, but unusual moulds such as Scedosporium spp are increasingly recognized as opportunistic pathogens in LT. This review highlights the changing spectrum of invasive fungal infections, risk factors, antifungal prophylaxis, diagnosis, and treatment after LT.
Solé
Amparo
A
Pulmonary Transplant Unit, Hospital Universitario La Fe, 46009 Valencia, Spain. sole_amp@gva.es
Salavert
Miguel
M
D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D002177:Candidiasis / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology* / Q000517:prevention & control; D016040:Lung Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D012307:Risk Factors
D000935:Antifungal Agents