title: Pre-existing major depression predicts in-hospital cardiac complications after acute myocardial infarction.
abstract: BACKGROUND
  Depression (MDD) and anxiety have been associated with negative long-term outcomes among patients with acute myocardial infarction (MI).
  
  
  OBJECTIVE
  The objective of the study was to determine whether MDD and anxiety preceding MI were associated with in-hospital post-MI cardiac complications.
  
  
  METHODS
  Subjects (N=129) underwent psychiatric interviews within 72 hours of MI and were evaluated for five in-hospital cardiac complications (recurrent ischemia, ventricular arrhythmia, ventricular arrhythmia requiring intervention, congestive heart failure, and reinfarction).
  
  
  RESULTS
  Current (pre-MI) MDD was a significant and independent predictor of all complications except recurrent ischemia on multivariate regression analysis. In contrast, pre-MI anxiety was not associated with complications.
  
  
  CONCLUSIONS
  These findings underscore the importance of identifying and treating MDD in post-MI patients and those at risk for MI.
authors.affiliation: Massachusetts General Hospital, 55 Fruit Street/Warren 1220C, Boston, MA 02114, USA. jhuffman@partners.org
authors.forename: Jeff C
authors.initials: JC
authors.lastname: Huffman
authors.forename: Felicia A
authors.initials: FA
authors.lastname: Smith
authors.forename: Mark A
authors.initials: MA
authors.lastname: Blais
authors.forename: Amy M
authors.initials: AM
authors.lastname: Taylor
authors.forename: James L
authors.initials: JL
authors.lastname: Januzzi
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Fricchione
mesh_terms: D001008:Anxiety Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000453:epidemiology*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000523:psychology* / Q000534:rehabilitation*; D011446:Prospective Studies; D012008:Recurrence