Case-control study of patients with essential tremor in Latvia.
BACKGROUND
Essential tremor (ET) is the most prevalent inherited movement disorder. ET has been mapped on chromosomes 2 and 3, but causative genes are not known.


METHODS
We genotyped 16 microsatellite markers in a case-control cohort consisting of 104 patients and 116 controls.


RESULTS
No significant difference between allele frequencies was found. The highest difference of frequencies was found in allele 171 of the marker D2S220 (OR 0.13, 95% CI 0.02-1.03, P = 0.05). In addition, we investigated the distribution of suspected disease gene DRD3 Ser9Gly polymorphism in the same patients and controls.


CONCLUSIONS
There was not a significant difference in genotypic distribution between disease group and control subjects (chi2 =2.8, P = 0.25).
Inashkina
I
I
Latvian Biomedical Research and Study Centre, Riga, Latvia.
Radovica
I
I
Smeltere
L
L
Vitols
E
E
Jankevics
E
E
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D002874:Chromosome Mapping; D020329:Essential Tremor / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D007844:Latvia / Q000453:epidemiology; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D050637:Receptors, Dopamine D3 / Q000235:genetics
C493593:DRD3 protein, human; D050637:Receptors, Dopamine D3