title: No reduction in C-reactive protein following a 12-month randomized controlled trial of exercise in men and women.
abstract: Low-grade systemic inflammation is suggested to play a role in the development of several chronic diseases including cancer. Higher levels of physical activity and lower adiposity have been associated with reduced levels of markers of systemic inflammation, such as C-reactive protein (CRP); however, reductions in CRP have not been consistently observed in randomized controlled trials of exercise.
  
  
  OBJECTIVE
  To examine the effect of a 12-month aerobic exercise intervention on CRP levels in men and women.
  
  
  METHODS
  One hundred two men and 100 women, sedentary and of ages 40 to 75 years, with mean body mass index (BMI) of 29.9 and 28.7 kg/m(2), respectively, were randomly assigned to a 12-month moderate-to-vigorous aerobic exercise intervention (6 d/wk, 60 min/d, 60-85% maximum heart rate) or control group. Fasting blood samples were collected at baseline and at 12 months. CRP levels were measured by high-sensitivity latex-enhanced nephelometry.
  
  
  RESULTS
  At baseline, CRP was 1.16 and 2.11 mg/L for men and women, respectively, and CRP was correlated with percent body fat (r = 0.48, P < or =0.001), BMI (r = 0.37, P < or = 0.001), and aerobic fitness (r = -0.49, P < or = 0.001). No intervention effects were observed for CRP in men or women, or when stratified by baseline BMI (<30 versus > or =30 kg/m(2)), baseline CRP (<3 versus > or =3 mg/L), or change in body weight, body composition, or aerobic fitness.
  
  
  CONCLUSIONS
  A 12-month moderate-to-vigorous aerobic exercise intervention did not affect CRP levels in previously sedentary men or women with average-risk CRP values at baseline.
authors.affiliation: Cancer Prevention Program, The Fred Hutchinson Cancer Research Center, Public Health Sciences, Seattle, WA 98109-1024, USA.
authors.forename: Kristin L
authors.initials: KL
authors.lastname: Campbell
authors.forename: Peter T
authors.initials: PT
authors.lastname: Campbell
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: Ulrich
authors.forename: Mark
authors.initials: M
authors.lastname: Wener
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Alfano
authors.forename: Karen
authors.initials: K
authors.lastname: Foster-Schubert
authors.forename: Rebecca E
authors.initials: RE
authors.lastname: Rudolph
authors.forename: John D
authors.initials: JD
authors.lastname: Potter
authors.forename: Anne
authors.initials: A
authors.lastname: McTiernan
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014481:United States / Q000453:epidemiology
chemical_list: D014408:Biomarkers, Tumor; D002097:C-Reactive Protein