title: Expression of transient receptor potential vanilloid (TRPV) 1, 2, 3, and 4 in mouse inner ear.
abstract: CONCLUSIONS
  It is suggested that transient receptor potential vanilloids (TRPVs) may play a functional role in cell physiology and TRPV-4 and -2 may play an important part in fluid homeostasis in the inner ear.
  
  
  OBJECTIVE
  Expression of TRPV-1, -2, -3, and -4 in the normal mouse inner ear was studied.
  
  
  METHODS
  CBA/J mice were used in this study. The localization of TRPV-1, -2, -3, and -4 in the inner ear, i.e. cochlea, vestibular end organs, and endolymphatic sac, was investigated by immunohistochemistry.
  
  
  RESULTS
  TRPV-1, -2, and -3 were co-expressed in hair cells and supporting cells of the organ of Corti, in spiral ganglion cells, sensory cells in vestibular end organs, vestibular ganglion cells, and sensory nerve fibers. TRPV-2 was also detected in the stria vascularis, dark cells, and endolymphatic sac. TRPV-4 was expressed in hair cells and supporting cells of the organ of Corti, in marginal cells of the stria vascularis, spiral ganglion cells, vestibular sensory cells, vestibular dark cells, vestibular ganglion cells, and epithelial cells of the endolymphatic sac.
authors.affiliation: Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan. d055860@hiroshima-u.ac.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Ishibashi
authors.forename: Masaya
authors.initials: M
authors.lastname: Takumida
authors.forename: Nana
authors.initials: N
authors.lastname: Akagi
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Hirakawa
authors.forename: Matti
authors.initials: M
authors.lastname: Anniko
mesh_terms: D000818:Animals; D007758:Ear, Inner / Q000378:metabolism*; D006309:Hearing; D051379:Mice; D008808:Mice, Inbred CBA; D004856:Postural Balance; D050916:TRPV Cation Channels / Q000378:metabolism*
chemical_list: D050916:TRPV Cation Channels