Looking for cancer clues in publicly accessible databases.
What started out as a mere attempt to tentatively identify proteins in experimental cancer-related 2D-PAGE maps developed into VIRTUAL2D, a web-accessible repository for theoretical pI/MW charts for 92 organisms. Using publicly available expression data, we developed a collection of tissue-specific plots based on differential gene expression between normal and diseased states. We use this comparative cancer proteomics knowledge base, known as the tissue molecular anatomy project (TMAP), to uncover threads of cancer markers common to several types of cancer and to relate this information to established biological pathways.
Medjahed
Djamel
D
National Cancer Institute at Frederick, 915 Tollhouse Avenue, Frederick, MD 21701, USA. medjahed@ncifcrf.gov
Lemkin
Peter F
PF
Smythers
Gary W
GW
Munroe
David J
DJ