title: Antecedents of domain-specific quality of life after colorectal cancer.
abstract: OBJECTIVE
  The present study prospectively assessed the influence of medical, socio-demographic, psychological, and lifestyle variables on physical, social/family, emotional, functional well-being and colorectal cancer-specific concerns in a population-based sample of colorectal cancer survivors.
  
  
  METHODS
  Participants (n=1822) were assessed at 6 and 24 months post-diagnosis. Predictor variables assessed at 6 months included socio-demographic and medical variables, symptoms/side-effects, body mass index, physical activity, optimism, social support, and cancer threat appraisal. Quality of life (QOL) was assessed at 6 and 24 months post-diagnosis using the Functional Assessment of Cancer Therapy - Colorectal (FACT-C).
  
  
  RESULTS
  For each QOL subscale and for the overall FACT-C scale, 6 month scores were the strongest predictor of QOL scores at 24 months post-diagnosis (e.g. beta=0.447, p < 0.001 for overall QOL). Socio-demographic, medical, and psychosocial variables, but not lifestyle variables, differentially predicted domain specific QOL. Only cancer threat appraisal was associated with all five QOL domains.
  
  
  CONCLUSIONS
  Cancer threat appraisal presents as a potentially modifiable variable for interventions seeking to improve QOL. Symptom management and lifestyle strategies to ameliorate the effects of co-morbidities, disease stage and troublesome symptoms such as faecal incontinence on QOL should also be included.
authors.affiliation: Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Queensland, Australia. SuzanneSteginga@cancerqld.org.au
authors.forename: Suzanne K
authors.initials: SK
authors.lastname: Steginga
authors.forename: Brigid M
authors.initials: BM
authors.lastname: Lynch
authors.forename: Anna
authors.initials: A
authors.lastname: Hawkes
authors.forename: Jeff
authors.initials: J
authors.lastname: Dunn
authors.forename: Joanne
authors.initials: J
authors.lastname: Aitken
mesh_terms: D000223:Adaptation, Psychological; D000368:Aged; D015179:Colorectal Neoplasms / Q000150:complications / Q000523:psychology / Q000534:rehabilitation*; D005260:Female; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D015999:Multivariate Analysis; D011788:Quality of Life; D011793:Queensland; D017741:Survivors / Q000523:psychology