title: Consequence of therapy discontinuation in bisphosphonate-associated osteonecrosis of the jaws.
abstract: We report a patient with bisphosphonate-associated osteonecrosis of the jaws who developed pathological fractures of the upper and lower extremities after the suspension of treatment with bisphosphonates. Temporary discontinuation of the drugs does not alter the clinical course of the disease, and could result in the recurrence of bone pain and the progression of metastases or osteolytic lesions.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Central Hospital, Oviedo, Spain.
authors.forename: Lorena
authors.initials: L
authors.lastname: Gallego
authors.forename: Luis
authors.initials: L
authors.lastname: Junquera
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy; D002710:Chlorhexidine / Q000627:therapeutic use; D003646:Debridement; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000627:therapeutic use; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects*; D008439:Maxillary Diseases / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D008875:Middle Aged; D009067:Mouthwashes; D009101:Multiple Myeloma / Q000188:drug therapy; D009957:Oroantral Fistula / Q000209:etiology; D010020:Osteonecrosis / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D014081:Tooth Extraction / Q000009:adverse effects; D000077211:Zoledronic Acid
chemical_list: D000891:Anti-Infective Agents, Local; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D009067:Mouthwashes; D000077211:Zoledronic Acid; D019980:Amoxicillin-Potassium Clavulanate Combination; D006861:Hydrogen Peroxide; D002710:Chlorhexidine