title: Differences in testicular development between 5alpha-reductase 2 deficiency and isolated bilateral cryptorchidism.
abstract: OBJECTIVE
  We demonstrated that infertility develops in most patients with steroid 5alpha-reductase 2 deficiency.
  
  
  METHODS
  We compared the testicular histopathology of boys with steroid 5alpha-reductase 2 deficiency to that of boys with isolated bilateral cryptorchidism.
  
  
  RESULTS
  Testes with steroid 5alpha-reductase 2 deficiency lacked spermatocytes but had Ad spermatogonia and a normal germ cell count. In contrast, bilateral cryptorchid testes had severe germ cell depletion and the majority lacked Ad spermatogonia.
  
  
  CONCLUSIONS
  In patients with steroid 5alpha-reductase 2 deficiency the impaired second step of germ cell maturation results in defective transformation of spermatogonia into spermatocytes. The position of the undescended testis appears to have no major pathological impact on the development of germ cells in patients with steroid 5alpha-reductase 2 deficiency.
authors.affiliation: Kindertagesklinik Liestal, Liestal, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Hadziselimovic
authors.forename: N
authors.initials: N
authors.lastname: Dessouky
mesh_terms: D002648:Child; D002675:Child, Preschool; D042944:Cholestenone 5 alpha-Reductase / Q000172:deficiency*; D003456:Cryptorchidism / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007223:Infant; D007248:Infertility, Male / Q000201:enzymology*; D008297:Male; D010641:Phenotype; D013076:Sperm Count; D013091:Spermatogenesis / Q000502:physiology; D013094:Spermatozoa / Q000473:pathology
chemical_list: D042944:Cholestenone 5 alpha-Reductase