Sinulodurins A and B, antiproliferative and anti-invasive diterpenes from the soft coral Sinularia dura.
Two new diterpenes, sinulodurin A (1) and sinulodurin B (2), along with two known sterols, 24 S-methyl cholesterol and 24-methylene cholesterol, were isolated from the Palau soft coral Sinularia dura. The structures of the new metabolites were determined on the basis of spectroscopic methods and by comparison of NMR data with those of related metabolites. Sinulodurin A (1) and sinulodurin B (2) showed antiproliferative activity against highly malignant +SA mammary epithelial cells with an IC 50 range of 20-30 microM. They also displayed anti-invasive activity against human highly metastatic prostate cancer PC-3M-CT+ cells in the spheroid disaggregation assay. Furthermore, the antimicrobial activities of the isolates were tested.
Radwan
Mohamed M
MM
National Center for Natural Products Research, University of Mississippi, University, Mississippi 38677-1848, USA.
Manly
Susan P
SP
El Sayed
Khalid A
KA
Wali
Vikram B
VB
Sylvester
Paul W
PW
Awate
Bhushan
B
Shah
Girish
G
Ross
Samir A
SA
D000818:Animals; D037421:Anthozoa; D049109:Cell Proliferation / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009361:Neoplasm Invasiveness / Q000517:prevention & control*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D004224:Diterpenes; C533362:sinulodurin A; C533361:sinulodurin B