Necrotic cell death and 'necrostatins': now we can control cellular explosion.
The receptor-interacting protein 1 (RIP1) kinase activity is necessary for death-receptor-induced necrotic cell death. Recently, it has been demonstrated that 'necrostatins' efficiently block tumor necrosis factor-induced necrotic cell death through the inhibition of RIP1 kinase activity. This discovery supports the concept that receptor-induced necrosis, just like apoptosis, is a controlled cellular process. In addition, necrostatins are becoming important tools for evaluating the contribution of necrotic cell death in experimental disease models.
Vandenabeele
Peter
P
Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium. Peter.Vandenabeele@dmbr.UGent.be
Declercq
Wim
W
Vanden Berghe
Tom
T
D000818:Animals; D016923:Cell Death; D006801:Humans; D009336:Necrosis; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000378:metabolism
D053422:Receptor-Interacting Protein Serine-Threonine Kinases