title: On Using Truncated Sequential Probability Ratio Test Boundaries for Monte Carlo Implementation of Hypothesis Tests.
abstract: When designing programs or software for the implementation of Monte Carlo (MC) hypothesis tests, we can save computation time by using sequential stopping boundaries. Such boundaries imply stopping resampling after relatively few replications if the early replications indicate a very large or very small p-value. We study a truncated sequential probability ratio test (SPRT) boundary and provide a tractable algorithm to implement it. We review two properties desired of any MC p-value, the validity of the p-value and a small resampling risk, where resampling risk is the probability that the accept/reject decision will be different than the decision from complete enumeration. We show how the algorithm can be used to calculate a valid p-value and confidence intervals for any truncated SPRT boundary. We show that a class of SPRT boundaries is minimax with respect to resampling risk and recommend a truncated version of boundaries in that class by comparing their resampling risk (RR) to the RR of fixed boundaries with the same maximum resample size. We study the lack of validity of some simple estimators of p-values and offer a new simple valid p-value for the recommended truncated SPRT boundary. We explore the use of these methods in a practical example and provide the MChtest R package to perform the methods.
authors.affiliation: National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive MSC 7609, Bethesda, MD 20892-7609.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Fay
authors.forename: Hyune-Ju
authors.initials: HJ
authors.lastname: Kim
authors.forename: Mark
authors.initials: M
authors.lastname: Hachey