title: Plasmatic level of neurosin predicts outcome of mild cognitive impairment.
abstract: BACKGROUND
  Mild Cognitive Impairment (MCI) is a disorder considered to be a transitional stage from health to dementia. Diagnosis of dementias at these early stages is always troublesome because the pathophysiologic events leading to dementia precede clinical symptoms. Thus, the development of biomarkers that can be used to support the diagnosis of dementias at early stages is rapidly becoming a high priority. We have recently reported the value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease (AD). The aim of this study is to determine whether measuring plasmatic concentration of neurosin is a valuable test to predict progression of MCI.
  
  
  METHODS
  Plasmatic neurosin concentrations were measured in 68 MCI patients and 70 controls subjects. Blood samples were obtained at the beginning of the study. Sixty six patients diagnosed with MCI were observed for 18 months. In 36 patients a second blood sample was obtained at the endpoint.
  
  
  RESULTS
  The mean value of plasmatic neurosin concentration differs significantly between MCI patients who converted to Dementia with vascular component, those who converted to AD, or those who remained at MCI stage. The relative risk of developing Dementia with vascular component when neurosin levels are higher than 5.25 ng/ml is 13 while the relative risk of developing mild AD when neurosin levels are lower than 5.25 ng/ml is 2. Increases in the levels of neurosin indicate progression to Dementia with vascular component.
  
  
  CONCLUSIONS
  The measurement of plasmatic neurosin level in patients diagnosed with MCI may predict conversion from MCI to Dementia with vascular component. A single measurement is also valuable to estimate the risk of developing AD and Dementia with vascular component. Finally, repeated measurement of plasmatic neurosin might be a useful test to predict outcome in patients with MCI.
authors.affiliation: Internal Medicine Department, Hospital Alvarez-Buylla, Mieres, Spain. manuelmenendez@gmail.com.
authors.forename: Manuel
authors.initials: M
authors.lastname: Menendez-Gonzalez
authors.forename: Patricia
authors.initials: P
authors.lastname: Castro-Santos
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Calatayud
authors.forename: Pablo
authors.initials: P
authors.lastname: Perez-Piñera
authors.forename: Renee
authors.initials: R
authors.lastname: Ribacoba
authors.forename: Marta
authors.initials: M
authors.lastname: Martinez-Rivera
authors.forename: Carmen
authors.initials: C
authors.lastname: Gutierrez
authors.forename: Alfonso
authors.initials: A
authors.lastname: Lopez-Muñiz
authors.forename: Ana
authors.initials: A
authors.lastname: Suarez