A new Schiff base copper (II) complex derived from estrone and d-glucosamine: Synthesis, characterization and its interaction with DNA.
A novel copper (II) complex of Schiff base prepared through condensation between 2-formyl-17-deoxyestrone and d-glucosamine was synthesized and characterized. Fluorescence spectroscopy was conducted to assess their binding ability with CT-DNA. The results showed that the copper (II) complex could bind to DNA with a weak intercalative mode. The interaction between the copper (II) complex and DNA was also investigated by gel electrophoresis. Interestingly, we found that the complex could cleave plasmid DNA (pUC19) to nicked and linear forms through an oxidative mechanism without the use of exogenous agents.
Yang
Xin-Bin
XB
Key Laboratory of Green Chemistry and Technology (Ministry of Education), Department of Chemistry, Sichuan University, Chengdu, P R China.
Wang
Li
L
Zhang
Ji
J
Zhang
Zhong-Wei
ZW
Lin
Hong-Hui
HH
Zhou
Li-Hong
LH
Yu
Xiao-Qi
XQ
D003300:Copper; D004247:DNA / Q000378:metabolism*; D053837:DNA Cleavage; D004970:Estrone / Q000737:chemistry*; D005944:Glucosamine / Q000737:chemistry*; D007364:Intercalating Agents; D009942:Organometallic Compounds; D010957:Plasmids / Q000378:metabolism; D012545:Schiff Bases / Q000138:chemical synthesis
D007364:Intercalating Agents; D009942:Organometallic Compounds; D012545:Schiff Bases; D004970:Estrone; D003300:Copper; D004247:DNA; D005944:Glucosamine