title: Relationship between clinical examination, quality of life, disability and depression in CMT patients: Italian multicenter study.
abstract: OBJECTIVE
  To assess which are the clinical examination tests that are more related to quality of life (QoL), depression, and disability in CMT patients.
  
  
  METHODS
  Large prospective multicenter study through the use of validated clinical, disability, and QoL measurements. Correlations between clinical pattern and disability/QoL and depression were studied.
  
  
  METHODS
  Departments of Neurology.
  
  
  METHODS
  211 CMT patients (60% females, mean age 42.5 years).
  
  
  METHODS
  None.
  
  
  RESULTS
  Sensory function was related to both mental and physical aspects of patient's QoL. Ability to walk on toes and heels was related to physical aspects of QoL/disability but also to bodily pain. Strength of forearm/hand intrinsic muscles was related to disability and physical aspects of QoL.
  
  
  CONCLUSIONS
  Some clinical tests may be better outcome measures than others because they are related to aspects of life highly relevant to the patients. This information may be useful in clinical practice and in clinical trials to infer the patient's QoL.
authors.affiliation: Institute of Neurology, Università Cattolica, Roma, Italy. lpadua@rm.unicatt.it
authors.forename: L
authors.initials: L
authors.lastname: Padua
authors.forename: I
authors.initials: I
authors.lastname: Aprile
authors.forename: T
authors.initials: T
authors.lastname: Cavallaro
authors.forename: I
authors.initials: I
authors.lastname: Commodari
authors.forename: D
authors.initials: D
authors.lastname: Pareyson
authors.forename: A
authors.initials: A
authors.lastname: Quattrone
authors.forename: N
authors.initials: N
authors.lastname: Rizzuto
authors.forename: G
authors.initials: G
authors.lastname: Vita
authors.forename: P
authors.initials: P
authors.lastname: Tonali
authors.forename: A
authors.initials: A
authors.lastname: Schenone
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002607:Charcot-Marie-Tooth Disease / Q000453:epidemiology* / Q000523:psychology*; D002648:Child; D003866:Depressive Disorder / Q000453:epidemiology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D010525:Peripheral Nerves / Q000503:physiopathology; D011237:Predictive Value of Tests; D011788:Quality of Life / Q000523:psychology*; D015203:Reproducibility of Results; D012678:Sensation Disorders / Q000453:epidemiology / Q000523:psychology