Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions.
Highly active antiretroviral treatment has resulted in dramatically increased life expectancy among patients with HIV infection who are now aging while receiving treatment and are at risk of developing chronic diseases associated with advanced age. Similarities between aging and the courses of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome suggest that HIV infection compresses the aging process, perhaps accelerating comorbidities and frailty. In a workshop organized by the Association of Specialty Professors, the Infectious Diseases Society of America, the HIV Medical Association, the National Institute on Aging, and the National Institute on Allergy and Infectious Diseases, researchers in infectious diseases, geriatrics, immunology, and gerontology met to review what is known about HIV infection and aging, to identify research gaps, and to suggest high priority topics for future research. Answers to the questions posed are likely to help prioritize and balance strategies to slow the progression of HIV infection, to address comorbidities and drug toxicity, and to enhance understanding about both HIV infection and aging.
Effros
Rita B
RB
David Geffen School of Medicine at the University of California, Los Angeles, USA.
Fletcher
Courtney V
CV
Gebo
Kelly
K
Halter
Jeffrey B
JB
Hazzard
William R
WR
Horne
Frances McFarland
FM
Huebner
Robin E
RE
Janoff
Edward N
EN
Justice
Amy C
AC
Kuritzkes
Daniel
D
Nayfield
Susan G
SG
Plaeger
Susan F
SF
Schmader
Kenneth E
KE
Ashworth
John R
JR
Campanelli
Christine
C
Clayton
Charles P
CP
Rada
Beth
B
Woolard
Nancy F
NF
High
Kevin P
KP
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000375:Aging / Q000276:immunology*; D023241:Antiretroviral Therapy, Highly Active; D002648:Child; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007109:Immunity; D007674:Kidney Diseases; D008107:Liver Diseases; D008659:Metabolic Diseases; D008875:Middle Aged; D012106:Research / Q000639:trends