[Circulating levels of oxidative stress and adipocytokines in obese subjects].
OBJECTIVE
To investigate the relationship between adipocytokines levels and oxidative stress in obese males.


METHODS
The levels of 8-iso-prostaglandinF2alpha(8-iso-PGF2alpha), superoxide dismutase (SOD), malondialdehyde (MDA), adiponectin, leptin, restistin, TNF-receptors 1(TNF-R1), Interleukin-1beta(IL-1beta) and Interleukin-6(IL-6) were measured in obese men and normal controls.


RESULTS
The levels of 8-iso-PGF(2alpha), MDA, leptin, TNF-R1, IL-1beta and IL-6 was significantly higher than that normal controls (P<0.05, P<0.01). The levels of adiponectin and the activity of SOD decreased significantly in obese men.There was no significant difference in the restistin between obese men and normal controls. There was significantly positive correlation between 8-iso-PGF(2alpha) and body mass index (BMI) (r=0.54, P<0.05) in obese. A significantly negative correlation was found between 8-iso-PGF(2alpha) and adiponectin (r=-0.56, P<0.05) in obese subjects. The levels of leptin was negative correlated with body fat content(%)(r=-0.53, P<0.05) in obese subjects. A significant negative correlation was observed between the levels of adiponectin and LDL(r=-0.54, P<0.05), IL-6 (r=-0.41, P<0.05). In a multiple regression analysis model, the levels of adiponectin and IL-6 were the main determinants of the oxidative stress in obese men.


CONCLUSIONS
Changed concentration of adipocytokines was found in obese men. There are significantly correlation with between oxidative stress and adipocytokines.
Shen
Xing-Ping
XP
Department of Endocrinology, Xiamen University Affiliated Zhongshan Hospital, Xiamen 361004, China.
Zou
Sen-Biao
SB
Wu
Hao-Jie
HJ
Zhang
Yan
Y
D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D001786:Blood Glucose; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology*; D012044:Regression Analysis; D013482:Superoxide Dismutase / Q000097:blood
D054392:Adipokines; D052242:Adiponectin; D001786:Blood Glucose; D053583:Interleukin-1beta; D015850:Interleukin-6; D020738:Leptin; C075750:8-epi-prostaglandin F2alpha; D008315:Malondialdehyde; D015237:Dinoprost; D013482:Superoxide Dismutase