title: [Pregnancy-associated breast cancer].
abstract: Pregnancy-associated breast cancer is a rare disease with an incidence of 1:3000. There is no indication anymore to terminate the pregnancy since the maternal prognosis will not be influenced. Due to physiologic pregnancy-related changes in the breast, the interpretation of clinical findings, breast ultrasound and mammography is more demanding. There is often a diagnostic delay in detecting pregnancy-associated breast cancer. Mastectomy and axillary lymphonodectomy compose the surgical therapy. In the third trimester, breast conserving surgery and radiotherapy postpartum is an option. Chemotherapy can be administered relatively safe in the second and third trimester. Radiotherapy, hormonal therapy and trastuzumab are contraindicated during pregnancy. Patients with pregnancy-associated breast cancer should be seen and treated in an interdisciplinary setting, preferably in a specialized centre.
authors.affiliation: Departement für Gynäkologie und Geburtshilfe, Universitätsspital Basel, Spitalstrasse 21, Basel.
authors.forename: Marie Christin
authors.initials: MC
authors.lastname: Eisenbrand
authors.forename: Edward
authors.initials: E
authors.lastname: Wight
authors.forename: Uwe
authors.initials: U
authors.lastname: Güth
authors.forename: Rosanna
authors.initials: R
authors.lastname: Zanetti-Dällenbach
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008197:Lymph Node Excision; D008408:Mastectomy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents