title: Effect of 17alpha-ethinyl estradiol on active phase rapid eye movement sleep microarchitecture.
abstract: Estrogen treatment decreases active phase rapid eye movement (REM) sleep in ovariectomized rats. Here we explored further the effect of 17alpha-ethinyl estradiol (17alpha-EE) on active phase REM sleep in ovariectomized rats by analyzing spectral properties and the number and length of REM sleep bouts. The greatest suppression of REM sleep occurred on day 4 of 17alpha-EE treatment, was due to decreases in bout length, and was accompanied by decreased EEG theta power. These results further elucidate 17alpha-EE's effects on REM sleep and provide greater understanding of the mechanisms by which estrogens alter sleep-wakefulness patterns.
authors.affiliation: Women's Health & Musculoskeletal Biology, Wyeth Research, Collegeville, PA 19426, USA. pawlyk@alumni.upenn.edu
authors.forename: Aaron C
authors.initials: AC
authors.lastname: Pawlyk
authors.forename: Peter D
authors.initials: PD
authors.lastname: Alfinito
authors.forename: Darlene C
authors.initials: DC
authors.lastname: Deecher
mesh_terms: D000818:Animals; D004967:Estrogens / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D010052:Ovariectomy; D017286:Polysomnography; D051381:Rats; D017207:Rats, Sprague-Dawley; D012894:Sleep Stages / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects*; D013826:Theta Rhythm; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects
chemical_list: D004967:Estrogens; D004997:Ethinyl Estradiol