title: Susceptibility of Pseudomonas aeruginosa to a photodynamic effect of the arginine hematoporphyrin derivative.
abstract: The photodynamic effect of the arginine hematoporphyrin derivative (HpD-Arg(2)) on the growth of selected Pseudomonas aeruginosa clinical isolates is described as compared to the effect of hematoporphyrin derivative (HpD). Growth inhibition of HpD-Arg(2) of three Gram-positive strains (Staphylococcus aureus, Bacillus subtilis and Micrococcus luteus) and five laboratory strains of Gram-negative bacteria (Escherichia coli, Proteus vulgaris, P. aeruginosa, Klebsiella pneumoniae and Enterobacter cloacae) was observed as well. Serratia marcescens strain was resistant to light-activated HpD-Arg(2) or HpD. The antimicrobial activity of light-activated HpD-Arg(2) against P. aeruginosa may offer an additional option in the anti-pseudomonal therapy of wounds.
authors.affiliation: Military Institute of Hygiene and Epidemiology, Kozielska 4, PL 01-163 Warsaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Szpakowska
authors.forename: J
authors.initials: J
authors.lastname: Reiss
authors.forename: A
authors.initials: A
authors.lastname: Graczyk
authors.forename: S
authors.initials: S
authors.lastname: Szmigielski
authors.forename: K
authors.initials: K
authors.lastname: Lasocki
authors.forename: J
authors.initials: J
authors.lastname: Grzybowski