[131I-MIBG therapy in the treatment of pheochromocytoma in children--own experiences].
Three cases of pheochromocytoma in children/adolescents or young adults treated by 131I-MIBG are presented in this study. In one patient 131I-MIBG was administrated after ineffective surgical treatment and chemotherapy of a benign retroperitoneal tumor, whereas in two other patients 131I-MIBG therapy was carried out because of malignant pheochromocytoma dissemination. In a child with retroperitoneal paraganglioma decrease of tumor size and its fibrosis after 131I-MIBG therapy allowed radical surgery and complete recovery. In two other cases partial remission was achieved. All patients showed a good subjective response with improvement of the general condition and better blood pressure control. In two children adverse reactions such as leucopenia, hypothyroidism or hypogonadism were observed. The presented data confirm effectiveness and acceptable tolerance of 131I-MIBG treatment in pheochromocytoma, what is very important in pediatric patients.
Hasse-Lazar
Kornelia
K
Zakład Medycyny Nuklearnej i Endokrynologii Onkologicznej, Centrum Onkologii-Instytut im. M. Skłodowskiej-Curie, Oddział w Gliwicach. klazar@wp.pl
Krajewska
Jolanta
J
Paliczka-Cieślik
Ewa
E
Jurecka-Lubieniecka
Beata
B
Michalik
Barbara
B
Handkiewicz-Junak
Daria
D
Roskosz
Józef
J
Jarzab
Barbara
B
D019797:3-Iodobenzylguanidine / Q000009:adverse effects / Q000627:therapeutic use*; D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D007006:Hypogonadism / Q000139:chemically induced; D007037:Hypothyroidism / Q000139:chemically induced; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D010673:Pheochromocytoma / Q000188:drug therapy / Q000532:radiotherapy*
D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes; D019797:3-Iodobenzylguanidine