title: Endocannabinoids and the neurochemistry of gluttony.
abstract: Cannabis exerts its actions by mimicking 'endocannabinoid' neuromodulators at CB1 receptors in brain and peripheral tissues. The endocannabinoids both stimulate appetite by increasing food craving and enjoyment and promote the deposition of energy as fat in adipose tissues. These findings have raised the possibility of CB1 antagonists as a novel class of anti-obesity agents.
authors.affiliation: School of Psychology, University of Liverpool, UK.
authors.forename: Tim
authors.initials: T
authors.lastname: Kirkham
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism / Q000502:physiology*; D063388:Endocannabinoids; D005247:Feeding Behavior / Q000502:physiology; D001068:Feeding and Eating Disorders / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D005502:Food / Q000009:adverse effects; D006801:Humans; D009417:Nerve Tissue / Q000737:chemistry / Q000473:pathology; D009448:Neurochemistry; D009765:Obesity / Q000209:etiology / Q000378:metabolism; D010684:Philosophy; D051381:Rats
chemical_list: D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids