title: Validation of clinical and image skin scoring systems for a single chronic discoid lupus erythematosus lesion.
abstract: OBJECTIVE
  The purpose of this study was to achieve a validated clinical and image scoring system for a single chronic discoid lupus erythematosus (CDLE) lesion.
  
  
  METHODS
  Fifteen patients with a CDLE lesion were scored twice by four observers and clinical photographs were taken. These pictures were assessed by the same four observers at two time points. Patients were scored using the DLE-Skin Score (DLE-SS). In addition, the DLE-Photo Score (DLE-PS) was calculated. Statistical analysis was carried out by measuring inter- and intra-observer agreement for both methods and by measuring the correlation between the DLE-SS and DLE-PS.
  
  
  RESULTS
  Both the DLE-SS and DLE-PS proved reliable methods in the assessment of CDLE. The inter-observer variability of the DLE-SS and DLE-SS was low. The intra-observer variability was estimated to be 0 in both methods. The correlation coefficient between the DLE-SS and DLE-PS was high (0.81).
  
  
  CONCLUSIONS
  Both the DLE-SS and the DLE-PS are reliable and easy-to-use methods to score disease activity in CDLE patients, and can be used in monitoring single target lesions in clinical trials.
authors.affiliation: Radboud University Nijmegen Medical Centre, Department of Dermatology, Nijmegen, The Netherlands. aerceg@amphia.nl
authors.forename: Angelina
authors.initials: A
authors.lastname: Erceg
authors.forename: Elke M J G
authors.initials: EM
authors.lastname: De Jong
authors.forename: Rosanne G
authors.initials: RG
authors.lastname: Van Lingen
authors.forename: Theo M
authors.initials: TM
authors.lastname: De Boo
authors.forename: Peter C M
authors.initials: PC
authors.lastname: Van De Kerkhof
authors.forename: Marieke M B
authors.initials: MM
authors.lastname: Seyger
mesh_terms: D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D010781:Photography; D010808:Physical Examination / Q000379:methods*; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index