title: Reversible siRNA-polymer conjugates by RAFT polymerization.
abstract: A straightforward synthetic method to prepare pyridyl disulfide end functionalized poly(PEG acrylate) by RAFT polymerization for efficient and reversible conjugation to siRNA is described.
authors.affiliation: Department of Chemistry & Biochemistry and the California NanoSystems Institute, University of California, 607 Charles E. Young Dr. East, Los Angeles, CA 90095, USA.
authors.forename: Karina L
authors.initials: KL
authors.lastname: Heredia
authors.forename: Thi H
authors.initials: TH
authors.lastname: Nguyen
authors.forename: Chien-Wen
authors.initials: CW
authors.lastname: Chang
authors.forename: Volga
authors.initials: V
authors.lastname: Bulmus
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Davis
authors.forename: Heather D
authors.initials: HD
authors.lastname: Maynard
mesh_terms: D000179:Acrylates / Q000138:chemical synthesis* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis*; D034741:RNA, Small Interfering / Q000737:chemistry*
chemical_list: D000179:Acrylates; D011108:Polymers; D034741:RNA, Small Interfering; D011092:Polyethylene Glycols