title: Norditerpenoid alkaloids from the roots of Aconitum heterophyllum   Wall with antibacterial activity.
abstract: Two new aconitine-type norditerpenoid alkaloids 6-dehydroacetylsepaconitine (1) and 13-hydroxylappaconitine (2), along with three known norditerpenoid alkaloids lycoctonine, delphatine and lappaconitine were isolated from the roots of the Aconitum heterophyllum Wall. These compounds exhibited significant antibacterial activity. The structure of compound 1 and 2 were deduced on the basis of their spectral data.
authors.affiliation: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. manzoorhej@yahoo.com
authors.forename: Manzoor
authors.initials: M
authors.lastname: Ahmad
authors.forename: Waqar
authors.initials: W
authors.lastname: Ahmad
authors.forename: Mansoor
authors.initials: M
authors.lastname: Ahmad
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zeeshan
authors.lastname: Obaidullah
authors.forename: Farzana
authors.initials: F
authors.lastname: Shaheen
mesh_terms: D031841:Aconitum / Q000737:chemistry* / Q000145:classification*; D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D004224:Diterpenes