Dectin-1 and its role in antifungal immunity.
The innate recognition of fungal pathogens is mediated by a variety of pattern recognition receptors (PRRs), although much interest has focussed on the Toll-like Receptors (TLR). More recently, however, there is growing appreciation that the non-TLRs have a major role in the control of infection with these organisms. One such molecule is Dectin-1, a C-type lectin-like receptor which induces numerous cellular responses upon recognition of fungal beta-glucans. Here we review our current understanding of the functions of Dectin-1 and the underlying molecular mechanisms, as well as explore the role of this receptor in antifungal immunity.
Kimberg
Matti
M
Institute of Infectious Disease and Molecular Medicine, Division of Immunology, University of Cape Town, Observatory, Cape Town, South Africa.
Brown
Gordon D
GD
D000818:Animals; D005658:Fungi / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D037181:Lectins, C-Type; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism*; D009181:Mycoses / Q000276:immunology*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D015398:Signal Transduction; D047071:beta-Glucans / Q000276:immunology; D000099181:Dectin-1
D037181:Lectins, C-Type; D008024:Ligands; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D047071:beta-Glucans; D000099181:Dectin-1