Monoolein-water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization.
To maximize the efficacy of chronic osteomyelitis antibiotherapy while reducing antibiotic systemic toxicity, as well as time and costs of hospitalizations, it has been thought that monoolein-water gels incorporating gentamicin sulfate could be used as local, bioresorbable,and sustained-release implants. For this purpose, four formulations were examined with regard to their physicochemical and in vitro drug release characteristics. Hot stage microscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA),and X-ray diffraction showed cubic liquid crystalline and eutectic structures. The more suitable formulation consisting of 80-15-5%wt/wt monoolein-water-gentamicin sulfate progressively released the antibiotic for a period of 3 weeks without burst effect. Moreover, the content and the release profile of gentamicin sulfate were not significantly changed after storage at 2-6 degrees C for a period of 10 months.
Ouédraogo
Moustapha
M
UFR-Sciences de la Santé, Université de Ouagadougou, Ouagadougou, Burkina Faso.
Semdé
Rasmané
R
Somé
Issa Toudoridomou
IT
Traoré-Ouédraogo
Rasmata
R
Guissou
Innocent Pierre
IP
Henschel
Viviane
V
Dubois
Jacques
J
Amighi
Karim
K
Evrard
Brigitte
B
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D002908:Chronic Disease; D003460:Crystallization; D003692:Delayed-Action Preparations; D004343:Drug Implants; D004355:Drug Stability; D004356:Drug Storage; D005839:Gentamicins / Q000008:administration & dosage* / Q000737:chemistry; D008853:Microscopy / Q000379:methods; D010019:Osteomyelitis / Q000188:drug therapy*; D012995:Solubility; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004343:Drug Implants; D005839:Gentamicins