title: Radiotherapy for Peyronie's Disease: a European survey.
abstract: OBJECTIVE
  Peyronie's Disease (PD) is a benign condition characterized by penile nodules, pain and curvature. Radiotherapy has been used for many years with positive outcomes, however all studies published were non-randomized or non-controlled. The purpose of this survey was to understand which treatment policy is followed in Europe before setting up a randomized trial.
  
  
  METHODS
  A questionnaire was sent out to 908 European radiotherapy institutions, 402 questionnaires were sent back and filled out correctly (44.5%). The questionnaire consisted of different items, regarding number of patients referred, fraction dose, total dose and technique used, and eventually treatment outcome of clinical trials.
  
  
  RESULTS
  Seventy-three institutions irradiate PD (19%), 304 do not (81%). Reasons for not treating were insufficient referrals from urologists or no interest in treating benign diseases. The most common fraction dose is 2 (range 0.5-8) Gy and the total radiation dose 20 (range 3-30) Gy. Most of the institutions use electrons (n = 44) or orthovoltage (n = 32). Decreased pain is reported in about 80% of the cases, and side effects by eight institutions.
  
  
  CONCLUSIONS
  So far, a large variation of treatment schedules for radiotherapy of PD has been detected in European countries. Although the results are good and side effects minimal, there is still a need to set up a European randomized trial to prospectively evaluate the efficacy of radiotherapy for PD.
authors.affiliation: Department of Radiation Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands. L.Incrocci@erasmusmc.nl
authors.forename: Luca
authors.initials: L
authors.lastname: Incrocci
authors.forename: Wim C J
authors.initials: WC
authors.lastname: Hop
authors.forename: Heinrich M
authors.initials: HM
authors.lastname: Seegenschmiedt
mesh_terms: D019583:Dose Fractionation, Radiation; D005060:Europe; D019538:Health Care Surveys; D006801:Humans; D008297:Male; D010411:Penile Induration / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011795:Surveys and Questionnaires