title: Darunavir: after multiple antiretroviral treatment failure: another option.
abstract: In HIV-infected patients with multiple antiretroviral treatment failure, two trials show that adding darunavir + ritonavir to optimised antiretroviral treatment is more effective than adding other protease inhibitors. Clinical trials, involving relatively few patients, revealed no significant adverse effects that had not previously been seen with HIV protease inhibitors. There is a high risk of drug interactions with darunavir.
mesh_terms: D044966:Anti-Retroviral Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D002986:Clinical Trials as Topic; D017277:Drug Approval; D018432:Drug Resistance, Multiple; D024882:Drug Resistance, Viral; D005060:Europe; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D044966:Anti-Retroviral Agents; D013449:Sulfonamides