Protective effect of polysaccharides from morinda officinalis on bone loss in ovariectomized rats.
In order to examine the effect of polysaccharides from morinda officinalis (MOP) on bone quality of osteoporosis rats. The osteoporosis in rats was induced by ovariectomy, and MOP (100 or 300 mg/kg) was orally administrated once daily. The animals were assessed 30 days after the operation for bone mineral density, serum cytokines level and mineral element concentration. MOP administration in rats resulted in an increase in bone mineral density and mineral element concentration, a decrease in serum cytokines level, which indicated that MOP administration may play an important role in the development of osteoporosis.
MengYong
Zhu
Z
The department of Orthopaedics in Taizhou Central Hospital, Taizhou 318000, Zhejiang, PR China.
CaiJiao
Wang
W
HuSheng
Zhang
Z
XianWu
Pei
P
JianMin
Fen
F
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D016207:Cytokines / Q000097:blood; D005260:Female; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D008903:Minerals / Q000378:metabolism; D032066:Morinda / Q000737:chemistry*; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D010052:Ovariectomy / Q000009:adverse effects; D011134:Polysaccharides / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D016207:Cytokines; D008903:Minerals; D011134:Polysaccharides