title: [Biochemical bone resorption markers during the healing of osteoporotic fractures].
abstract: BACKGROUND
  This study investigated the progression and clinical relevance of biochemical resorption marker values during fracture healing in osteoporosis.
  
  
  METHODS
  In 44 patients with distal radius fractures and 29 patients without fractures, the blood and urine concentrations of pyridinoline (PYD), deoxypyridinoline (DPD), N-telopeptides (NTx), and bone sialoprotein (BSP) were recorded on the day of trauma as well as during further progression. All postmenopausal patients underwent bone density measurement. Accordingly, patients were divided into premenopausal, postmenopausal osteoporotic, and postmenopausal nonosteoporotic groups.
  
  
  RESULTS
  Between the groups, PYD, DPD, and NTx showed significant differences in their initial values. However, their further relative progression was primarily affected by the chosen therapy.
  
  
  CONCLUSIONS
  Bone resorption markers can diagnostically point to osteoporosis and are significant parameters in fracture healing.
authors.affiliation: Klinik und Poliklinik für Unfallchirurgie, Universitätsklinikum Giessen-Marburg GmbH, Rudolf-Buchheim-Str. 7, 35385 Giessen, Deutschland. christian.heiss@chiru.med.uni-giessen.de
authors.forename: C
authors.initials: C
authors.lastname: Heiss
authors.forename: L M
authors.initials: LM
authors.lastname: Hoesel
authors.forename: M
authors.initials: M
authors.lastname: Pausch
authors.forename: S A
authors.initials: SA
authors.lastname: Meissner
authors.forename: U
authors.initials: U
authors.lastname: Horas
authors.forename: O
authors.initials: O
authors.lastname: Kilian
authors.forename: U
authors.initials: U
authors.lastname: Wehr
authors.forename: W A
authors.initials: WA
authors.lastname: Rambeck
authors.forename: R
authors.initials: R
authors.lastname: Schnettler
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D015519:Bone Density / Q000502:physiology; D001862:Bone Resorption / Q000503:physiopathology*; D024042:Collagen Type I / Q000378:metabolism; D005260:Female; D017102:Fracture Healing / Q000502:physiology*; D005598:Fractures, Spontaneous / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D058574:Integrin-Binding Sialoprotein; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology*; D010455:Peptides / Q000378:metabolism; D011885:Radius Fractures / Q000503:physiopathology*; D012016:Reference Values; D012795:Sialoglycoproteins / Q000378:metabolism; D014954:Wrist Injuries / Q000503:physiopathology* / Q000601:surgery
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; C546871:IBSP protein, human; D058574:Integrin-Binding Sialoprotein; D010455:Peptides; D012795:Sialoglycoproteins; C052929:collagen type I trimeric cross-linked peptide; C015484:pyridinoline; C036020:deoxypyridinoline