Plant histaminase as an investigational drug in splanchnic artery occlusion and reperfusion.
BACKGROUND
Amine oxidases are ubiquitous enzymes involved in the metabolism of biogenic amines. Copper amine oxidases catalyze the oxidative deamination of primary amine groups of several biogenic amines, such as putrescine, cadaverine and histamine.


OBJECTIVE
In the present review the effects of a plant amine oxidase (histaminase, EC1.4.3.6), purified from pea seedlings, in the prevention of splanchnic postischemic reperfusion damage are reported.


CONCLUSIONS
Various studies have clearly indicated that the use of histaminase will offer a good perspective for a novel therapeutic approach in the medical treatment of intestinal ischemia.
Cuzzocrea
Salvatore
S
University of Messina, School of Medicine, Department of Clinical, Experimental Medicine and Pharmacology, Torre Biologica-Policlinico Universitario, Via Consolare Valeria-Gazzi, 98100 Messina, Italy. salvator@unime.it
Masini
Emanuela
E
D006631:Amine Oxidase (Copper-Containing) / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000188:drug therapy* / Q000378:metabolism; D015507:Drugs, Investigational / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006632:Histamine / Q000378:metabolism; D006801:Humans; D018532:Pisum sativum / Q000201:enzymology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism; D012639:Seeds / Q000201:enzymology; D013152:Splanchnic Circulation
D015507:Drugs, Investigational; D017382:Reactive Oxygen Species; D006632:Histamine; D006631:Amine Oxidase (Copper-Containing)