title: The roles of local inhibition mediated by gamma-aminobutyric acid (GABA)-A receptor in duration tuning in the inferior colliculus of guinea pigs.
abstract: CONCLUSIONS
  GABA-mediated inhibition is responsible for the duration tuning in the inferior colliculus (IC) of guinea pigs, a non-echo-locating mammal. Duration tuning in this species is better demonstrated in an appropriate short time window.
  
  
  OBJECTIVE
  To investigate the role of GABA-mediated inhibition in duration tuning of neurons in the IC of guinea pigs.
  
  
  METHODS
  Duration tuning pattern was recorded by measuring the spikes of single neurons in response to broadband noise of different durations. The effect of GABA-mediated inhibition was verified by comparing the responses with and without the use of the GABA-A receptor blocker bicuculline (BIC), which was applied using micro-iontophoresis.
  
  
  RESULTS
  In addition to overall increase in responsiveness, the application of BIC was found to significantly reduce or eliminate the duration selectivity in 44 of the 67 neurons that showed clear duration tuning from a sample of total 340 neurons.
authors.affiliation: Affiliated Sixth People's Hospital, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Shankai
authors.initials: S
authors.lastname: Yin
authors.forename: Zhengnong
authors.initials: Z
authors.lastname: Chen
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Feng
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001307:Auditory Perception; D001640:Bicuculline / Q000494:pharmacology*; D005260:Female; D018756:GABA Antagonists / Q000494:pharmacology*; D058787:GABA-A Receptor Antagonists; D006168:Guinea Pigs; D007245:Inferior Colliculi / Q000166:cytology* / Q000502:physiology; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects*; D009474:Neurons / Q000502:physiology
chemical_list: D018756:GABA Antagonists; D058787:GABA-A Receptor Antagonists; D001640:Bicuculline