Bilateral multifocal retinal pigment epithelium detachments associated with systemic corticosteroids.
OBJECTIVE
To report an unusual case of central serous chorioretinopathy (CSC), presenting as bilateral and multifocal isolated serous retinal pigment epithelium detachments (RPEDs) following corticosteroid treatment.


METHODS
An otherwise healthy 39-year-old man was evaluated for visual loss following blunt trauma of his right eye (RE). The patient underwent complete bilateral ophthalmologic examination, including optical coherence tomography and fluorescein (FA) and indocyanine green angiography (ICGA).


RESULTS
At presentation, best-corrected visual acuity (BCVA) was 20/200 in the RE and 200/200 in the left eye (LE). Treatment included topical and oral corticosteroids. Three days later, the patient complained of metamorphopsia and further decrease in the VA of his RE. Fundus examination showed bilateral serous RPEDs. Optical coherence tomography, FA, and ICGA confirmed the diagnosis. Topical and oral corticosteroids were stopped and a follow-up examination 5 days later demonstrated marked resolution of the RPEDs in the RE. Five weeks later, RPEDs regressed in the RE while they persisted in the asymptomatic LE. Visual acuity in the RE further improved to 120/200. Nine months after the first visit, BCVA in the RE was 200/200. At that time, both eyes demonstrated retinal pigment epitheliopathy.


CONCLUSIONS
Central serous chorioretinopathy is a known complication of corticosteroids. The classic variant of CSC consists of a shallow neuroretinal detachment located at the posterior pole of the fundus. Bilateral and multifocal isolated serous RPEDs represent an atypical form of CSC.
Mendrinos
E
E
Department of Ophthalmology, Geneva University Hospitals, Geneva, Switzerland.
Mavrakanas
N
N
Dang-Burgener
N P
NP
Pournaras
C J
CJ
D000058:Accidental Falls; D000328:Adult; D004359:Drug Therapy, Combination; D004487:Edema / Q000188:drug therapy / Q000209:etiology; D005451:Fluorescein Angiography; D007839:Functional Laterality; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D010857:Pigment Epithelium of Eye / Q000187:drug effects* / Q000473:pathology; D011239:Prednisolone / Q000009:adverse effects; D011241:Prednisone / Q000009:adverse effects; D012163:Retinal Detachment / Q000139:chemically induced* / Q000175:diagnosis; D012164:Retinal Diseases / Q000188:drug therapy / Q000209:etiology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D014949:Wounds, Nonpenetrating / Q000188:drug therapy / Q000209:etiology
D005938:Glucocorticoids; D011239:Prednisolone; D007208:Indocyanine Green; D011241:Prednisone