Preparation of aryloxetanes and arylazetidines by use of an alkyl-aryl suzuki coupling.
The oxetan-3-yl and azetidin-3-yl substituents have previously been identified as privileged motifs within medicinal chemistry. An efficient approach to installing these two modules into aromatic systems, using a nickel-mediated alkyl-aryl Suzuki coupling, is presented.
Duncton
Matthew A J
MA
Evotec (USA), Two Corporate Drive, South San Francisco, California 94080, USA. mattduncton@yahoo.com
Estiarte
M Angels
MA
Tan
Darlene
D
Kaub
Carl
C
O'Mahony
Donogh J R
DJ
Johnson
Russell J
RJ
Cox
Matthew
M
Edwards
William T
WT
Wan
Min
M
Kincaid
John
J
Kelly
Michael G
MG
D001384:Azetidines / Q000138:chemical synthesis*; D001555:Benzene Derivatives / Q000138:chemical synthesis*; D004988:Ethers, Cyclic / Q000138:chemical synthesis*
D001384:Azetidines; D001555:Benzene Derivatives; D004988:Ethers, Cyclic; C005287:oxetane