title: HRMS directly from TLC slides. A powerful tool for rapid analysis of organic mixtures.
abstract: High-resolution mass spectra (HRMS) of individual spots on thin-layer chromatography (TLC) slides can now be obtained quickly and easily at atmospheric pressure, with zero sample preparation, using commercially available instrumentation. The method is complementary to GC-mass spectrometry but is not limited to compounds of high volatility and high thermal stability. TLC-HRMS can be used to monitor chemical reactions in real time and has the capacity thereby to accelerate significantly the pace of synthetic organic chemistry.
authors.affiliation: Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467-3860, USA.
authors.forename: Natalie J
authors.initials: NJ
authors.lastname: Smith
authors.forename: Marek A
authors.initials: MA
authors.lastname: Domin
authors.forename: Lawrence T
authors.initials: LT
authors.lastname: Scott
mesh_terms: D002855:Chromatography, Thin Layer / Q000295:instrumentation / Q000379:methods*; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D008567:Membranes, Artificial; D015394:Molecular Structure; D009930:Organic Chemicals / Q000032:analysis*; D012680:Sensitivity and Specificity
chemical_list: D008567:Membranes, Artificial; D009930:Organic Chemicals