Synthesis of azatricyclodiones & octahydro-benzo[f]isoindoles and their antimicrobial evaluation.
A series of azatricyclodiones and octahydro-benzo[f]isoindoles have been synthesized by (4+2) Diels-Alder cycloaddition of maleimides with furfuryl amine. Reaction of azatricyclodiones with isocyanates led to the respective ureides. All of the compounds were screened against a number of bacteria and fungi. One of the compounds (2) displayed moderate antitubercular activity while two compounds (2) and (4) inhibited the fungal growth at 25 μg/mL.
Saxena
Nisha
N
Medicinal and Process Chemistry Division Central Drug Research Institute, Lucknow, 226001, India.
Singh
Nimisha T
NT
Mishra
Mridul
M
Keshava
G B Shiva
GB
Shukla
Praveen Kumar
PK
Tripathi
Rama Pati
RP
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D061565:Cycloaddition Reaction; D005658:Fungi / Q000187:drug effects; D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000995:Antitubercular Agents; D001372:Aza Compounds; D054833:Isoindoles