title: Hypertrophic osteoarthropathy effectively treated with zoledronic acid.
abstract: Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by digital clubbing, arthralgias, and tissue swelling and is frequently described in association with bronchogenic carcinoma. The associated pain can be disabling, and symptoms are often resistant to conventional analgesic medications. We present a patient with HOA of the lower extremities and wrists that developed after bronchogenic carcinoma. The pain and swelling completely resolved after a single administration of 4 mg of zoledronic acid. The proposed pathogenesis of HOA and the mechanisms by which bisphosphonates might alleviate symptoms are reviewed.
authors.affiliation: Department of Hematology/Oncology, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, TX 78236, USA. melissa.king@lackland.af.mil
authors.forename: Melissa M
authors.initials: MM
authors.lastname: King
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Nelson
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002283:Carcinoma, Bronchogenic / Q000150:complications; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000150:complications; D008875:Middle Aged; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid