Reversible siRNA-polymer conjugates by RAFT polymerization.
A straightforward synthetic method to prepare pyridyl disulfide end functionalized poly(PEG acrylate) by RAFT polymerization for efficient and reversible conjugation to siRNA is described.
Heredia
Karina L
KL
Department of Chemistry & Biochemistry and the California NanoSystems Institute, University of California, 607 Charles E. Young Dr. East, Los Angeles, CA 90095, USA.
Nguyen
Thi H
TH
Chang
Chien-Wen
CW
Bulmus
Volga
V
Davis
Thomas P
TP
Maynard
Heather D
HD
D000179:Acrylates / Q000138:chemical synthesis* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis*; D034741:RNA, Small Interfering / Q000737:chemistry*
D000179:Acrylates; D011108:Polymers; D034741:RNA, Small Interfering; D011092:Polyethylene Glycols