title: A role for neurological memory feedback loops in psychiatric depression.
abstract: This hypothesis proposes a neurological system model of memory feedback loops which demonstrates the difference in specific memory processing between depressed and non-depressed people. It is suggested that non-depressed people have a functioning neurological memory feedback loop system which enables them to re-appraise and be more circumspect with given situations. In contrast to this, it is suggested that depressed people do not have a functioning memory feedback loop and it is this that leads to the deficit of circumspect and considered thinking. This could explain why depressed people commonly exhibit instantaneous negative reactions to events that pre-morbidity were considered to be pleasurable or interesting.
authors.affiliation: University of Leeds, 9 Sandhill Oval, Leeds LS17 8EB, United Kingdom. afrais@tiscali.co.uk
authors.forename: Anthony T
authors.initials: AT
authors.lastname: Frais
mesh_terms: D003863:Depression / Q000523:psychology*; D005246:Feedback; D006801:Humans; D008568:Memory; D008960:Models, Psychological