Attenuation of anxiety-related behaviour after the antagonism of transient receptor potential vanilloid type 1 channels in the rat ventral hippocampus.
The neurochemical mechanisms supporting the role of the ventral hippocampus in anxiety are now under investigation. To address this issue, we examined whether the pharmacological blockade of transient receptor potential vanilloid type 1 (TRPV1) channels in the ventral hippocampus would attenuate anxiety-related behaviour. Rats infused with the TRPV1 channel antagonist capsazepine (2.0 nmol) showed less inhibitory avoidance than controls in the elevated plus-maze test. This result indicates an anxiolytic-like effect, and suggests a role for TRPV1 channels in regulating anxiety.
Santos
Carolina J P A
CJ
Department of Pharmacology, Biological Sciences Centre, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Stern
Cristina A J
CA
Bertoglio
Leandro J
LJ
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000378:metabolism* / Q000523:psychology; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors* / Q000378:metabolism
D014151:Anti-Anxiety Agents; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; C071423:capsazepine; D002211:Capsaicin