The neural substrates of affective face recognition in patients with Hwa-Byung and healthy individuals in Korea.
Hwa-Byung (HB) is a Korean culture-bound psychiatric syndrome caused by the suppression of anger. HB patients have various psychological and somatic symptoms, such as chest discomfort, a sensation of heat, and the sensation of having an epigastric mass. In this study, we measured brain activity in HB patients and healthy individuals in response to affective facial stimuli. Using functional magnetic resonance imaging (fMRI), the current study measured neural responses to neutral, sad, and angry facial stimuli in 12 healthy individuals and 12 patients with HB. In response to all types of facial stimuli, HB patients showed increased activations in the lingual gyrus and fusiform gyrus compared with healthy persons, but they showed relatively lower activation in the thalamus. We also found that patients with HB showed lower activity in response to the neutral condition in the right ACC than healthy controls. The current study indicates that the suppression of affect results in aberrant function of the brain regions of the visual pathway, and functional impairment in the ACC may contribute to the pathophysiology of HB.
Lee
Byeong-Taek
BT
Department of Psychiatry, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, South Korea.
Paik
Jong-Woo
JW
Kang
Rhee-Hun
RH
Chung
Sun-Yong
SY
Kwon
Ho-In
HI
Khang
Hyun-Soo
HS
Lyoo
In Kyoon
IK
Chae
Jeong-Ho
JH
Kwon
Jung-Hye
JH
Kim
Jong-Woo
JW
Lee
Min-Soo
MS
Ham
Byung-Joo
BJ
D000328:Adult; D000339:Affect / Q000502:physiology*; D000786:Anger / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D003431:Cross-Cultural Comparison; D005149:Facial Expression; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010364:Pattern Recognition, Visual / Q000502:physiology*; D021641:Recognition, Psychology / Q000502:physiology*; D012016:Reference Values; D056910:Republic of Korea; D013001:Somatoform Disorders / Q000503:physiopathology* / Q000523:psychology; D013577:Syndrome; D013788:Thalamus / Q000503:physiopathology; D014795:Visual Pathways / Q000503:physiopathology