Resolution of syringomyelia and Chiari malformation after growth hormone therapy.
BACKGROUND
The association between hypopituitarism, Chiari I malformation, and syringomyelia has been recently recognized. Most of the reported patients suffered perinatal injury or asphyxia.


METHODS
We present the case of a premature child without identifiable perinatal injury, who was recognized to have growth hormone (GH) deficiency, Chiari I malformation, and syringohydromyelia.


CONCLUSIONS
There was a resolution of syrinx and tonsillar herniation after GH replacement.
Gupta
Ashok
A
Division of Pediatric Neurosurgery, Department of Pediatric Surgery, British Columbia Children's Hospital/Children's and Women's Health Centre, 4480 Oak St, #K3-159, Vancouver, BC, Canada.
Vitali
Aleksander M
AM
Rothstein
Ralph
R
Cochrane
D Douglas
DD
D001139:Arnold-Chiari Malformation / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D002648:Child; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008279:Magnetic Resonance Imaging; D008297:Male; D013595:Syringomyelia / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D013974:Thyroxine / Q000627:therapeutic use
D019382:Human Growth Hormone; D013974:Thyroxine