title: Squamous cell carcinoma of the gingivobuccal complex: predictors of locoregional failure in stage III-IV cancers.
abstract: The purpose of our study was to analyze the indicators of loco-regional failure in a large cohort of patients with gingivobuccal complex tumors treated at a single institution. A retrospective review of 2275 patients diagnosed with tumors of the gingivobuccal complex was conducted from January 1997 to December 1999; 642 patients who fulfilled our inclusion criteria were analyzed. A univariate analysis, multivariate analysis, and disease-free survival are reported. During a median follow up of 2.51 years, there were 228 (35.5%) recurrences with a median post-recurrence survival of 2.7 months. The incidence of occult neck metastasis was 29%. The 2- and 5-year DFS rates were 63.8% and 53.3%, respectively. On multivariate analysis, tumor depth and metastatic lymphadenopathy were found to be independent prognostic factors for disease-free survival. Advanced gingivobuccal cancers fail loco-regionally. Cervical metastasis and tumor depth influence disease-free survival. Elective neck dissection due to a high incidence of occult neck disease is recommended.
authors.affiliation: Department of Head and Neck Surgery, Tata Memorial Hospital, Dr. E. Borges Marg, Parel, Mumbai 400 012, India.
authors.forename: Rohan R
authors.initials: RR
authors.lastname: Walvekar
authors.forename: Devendra A
authors.initials: DA
authors.lastname: Chaukar
authors.forename: Mandar S
authors.initials: MS
authors.lastname: Deshpande
authors.forename: Prathamesh S
authors.initials: PS
authors.lastname: Pai
authors.forename: Pankaj
authors.initials: P
authors.lastname: Chaturvedi
authors.forename: Anagha
authors.initials: A
authors.lastname: Kakade
authors.forename: Anil K
authors.initials: AK
authors.lastname: D'Cruz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000556:secondary; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005887:Gingival Neoplasms / Q000401:mortality / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D055815:Young Adult