title: The efficacy of dexmedetomidine in patients with noninvasive ventilation: a preliminary study.
abstract: BACKGROUND
  Agitation is associated with failure of noninvasive ventilation (NIV). We investigated the effect of dexmedetomidine in patients with NIV.
  
  
  METHODS
  This was a prospective clinical investigation in an intensive care unit. Dexmedetomidine was infused in 10 patients in whom NIV was difficult because of agitation.
  
  
  RESULTS
  Ramsay and Richmond Agitation-Sedation Scale scores were maintained at 2.94 +/- 0.94 and -1.23 +/- 1.30, respectively. All patients were successfully weaned from NIV, and the respiratory state was not worsened.
  
  
  CONCLUSIONS
  This study shows that dexmedetomidine is an effective sedative drug for patients with NIV.
authors.affiliation: Department of Anesthesiology and Intensive Care, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Akada
authors.forename: Shinhiro
authors.initials: S
authors.lastname: Takeda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Keiko
authors.initials: K
authors.lastname: Nakazato
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
authors.forename: Takashi
authors.initials: T
authors.lastname: Hongo
authors.forename: Keiji
authors.initials: K
authors.lastname: Tanaka
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Sakamoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020927:Dexmedetomidine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011595:Psychomotor Agitation / Q000517:prevention & control; D012121:Respiration, Artificial / Q000379:methods*
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine