title: [Pilot study on M2-PK-- a new non-invasive parameter for early diagnosis of colorectal carcinoma].
abstract: To determine the level of tumor marker pyruvate kinase dimer (M2-PK) in the feces of patients with colorectal cancer and benign polyps, as well as in individuals with chronic inflammatory bowel diseases. Fecal M2-PK determination could be outlined as a highly reliable non-invasive approach to the diagnosis of colorectal carcinoma. The establishing of elevated values in patients with chronic inflammatory bowel diseases decreases the specificity of M2-PK as a tumor marker. However, this does not compromise its essential clinical significance, because the precise diagnosis in both diseases imposes an obligatory performance of colonoscopy.
authors.forename: A
authors.initials: A
authors.lastname: Ivanova
authors.forename: N
authors.initials: N
authors.lastname: Iarŭmov
authors.forename: S
authors.initials: S
authors.lastname: Toshev
authors.forename: D
authors.initials: D
authors.lastname: Adzharov
authors.forename: Z
authors.initials: Z
authors.lastname: Krŭstev
authors.forename: K
authors.initials: K
authors.lastname: Angelov
authors.forename: M
authors.initials: M
authors.lastname: Sokolov
authors.forename: P
authors.initials: P
authors.lastname: Gribnev
mesh_terms: D003111:Colonic Polyps / Q000175:diagnosis / Q000201:enzymology; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000201:enzymology; D042241:Early Diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011770:Pyruvate Kinase / Q000032:analysis* / Q000378:metabolism; D012680:Sensitivity and Specificity
chemical_list: D011770:Pyruvate Kinase