[Y-chromosome microdeletions as a prognostic marker of male infertility].
The results of molecular-genetic study of Y-chromosome microdeletions in men with spermatogenesis failure and in patients with cryptorchism are presented. The molecular-genetic studies of regions AZFa, AZFb, AZFc in STS loci - sY84, sY86, sY127, sY134, sY254, sY255 and SRY gene have been performed. Y-chromosome microdeletions were detected in 13,3% infertile men with spermogram failure. The frequency of genetic (cyto- and molecular) abnormalities among boys with isolated cryptorchism was 4%. The results show the necessity of additional study ofgenetic factors ofcryptorchism development.
Tyrkus
M Ia
MIa
Makukh
H V
HV
Zastavna
D V
DV
Huleiuk
N L
NL
Nakonechnyĭ
A I
AI
Stoĭka
B R
BR
D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004587:Electrophoresis, Agar Gel; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007621:Karyotyping; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D016133:Polymerase Chain Reaction; D011379:Prognosis
D004247:DNA