Microdialysis applications in neuroscience.
BACKGROUND
Microdialysis is a technique to monitor extracellular changes in living tissue. Substances present in the extracellular space, such as neurotransmitters and metabolites transported between cells and capillaries in the extracellular fluid (ECF), are major object.


RESULTS
Since its introduction to the research of the nervous system, microdialysis has become a popular method for the measurements of brain chemistry and greatly affected in the fields of neuropharmacology, neuroanatomy and neurophysiology. Most of published papers using microdialysis have focused on the area of neuroscience, recently more biomedical application.


CONCLUSIONS
In this review, we focused on cerebral microdialysis as a monitoring tool for physiologic and pathophysiologic changes in chemical processes in the brain. Then we presented the principle and various applications of cerebral microdialysis.
Lee
Gi Ja
GJ
Department of Biomedical Engineering, College of Medicine, Healthcare Industry Research Institute, Kyung Hee University, No. 1 Hoeki-dong, Dongdaemun-gu, Seoul 130-702, Korea.
Park
Ji Hye
JH
Park
Hun Kuk
HK
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002404:Catheterization / Q000295:instrumentation; D004058:Diffusion; D004563:Electrochemistry; D004566:Electrodes / Q000592:standards; D045604:Extracellular Fluid / Q000737:chemistry*; D006801:Humans; D017551:Microdialysis / Q000295:instrumentation / Q000379:methods*; D009448:Neurochemistry / Q000295:instrumentation / Q000379:methods*; D009488:Neurosciences / Q000295:instrumentation / Q000379:methods*; D018377:Neurotransmitter Agents / Q000032:analysis / Q000378:metabolism
D018377:Neurotransmitter Agents