Short-term success, but long-term treatment failure with linezolid for enterococcal endocarditis.
We report a case of linezolid treatment failure for Enterococcus faecalis endocarditis. Despite success during and shortly after treatment, the patient had a relapse after 7 weeks. Due to prior anaphylactic reaction to penicillin, desensitization was performed, and successful penicillin therapy given. The efficacy of linezolid for enterococcal endocarditis remains questionable.
Berdal
Jan-Erik
JE
Medical Division, Infectious Disease Department, Akershus University Hospital, Lorenskog, Norway. jan.erik.berdal@ahus.no
Eskesen
Arne
A
D000081:Acetamides / Q000008:administration & dosage / Q000627:therapeutic use*; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D013293:Enterococcus faecalis / Q000187:drug effects*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D000069349:Linezolid; D008297:Male; D023303:Oxazolidinones / Q000008:administration & dosage / Q000627:therapeutic use*; D017211:Treatment Failure
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid