title: [Densiron-68 heavy silicone oil in cases of PVR. Anatomic and functional outcomes].
abstract: OBJECTIVE
  To evaluate the safety and efficacy of Densiron-68 heavy silicone oil in the clinical management of complex retinal detachments with proliferative vitreoretinopathy (PVR).
  
  
  METHODS
  We present a prospective, interventional noncomparative case series of 80 eyes of 79 consecutive patients. The primary end point was anatomical reattachment of the retina, defined as retinal reattachment in the absence of any tamponade agent. The secondary end point was to record the visual function and surgical complications. Inclusion criteria were PVR stages B-CA4, including posterior or inferior retinal breaks and the patient's inability to posture.
  
  
  RESULTS
  Patients were 59.1 (+/-18.1) years old, male:female =48:32, R:L=40:40. Fifty-six patients (70%) had previous unsuccessful retinal surgery, and 24 (30%) received heavy silicone oil at their first procedure. The extent of the detachments was 2.46 quadrants (+/-0.83) with macular involvement in 49 cases (61%). Fifty-six (67.5%) patients achieved retinal reattachment with one retinal operation and no tamponade, 64 (80%) achieved retinal reattachment with more than one operation and no tamponade, and 72 (90%) achieved a flat retina with tamponade in situ. Visual acuity rose from 1.48 LogMar (+/-0.91) to 1.12 (+/-0.82; p=0.009). Densiron was removed after 126 days (+/-55.1).
  
  
  CONCLUSIONS
  The treatment of PVR remains challenging. No tamponade agent can provide simultaneous support for the superior as well as the inferior retina; therefore, a tamponade agent that "sinks" is a welcome new tool for the surgeon. We regard the use of heavy as well as conventional silicone oil as complementary to each other.
authors.affiliation: St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool. retina@online.ms
authors.forename: T
authors.initials: T
authors.lastname: Stappler
authors.forename: H
authors.initials: H
authors.lastname: Heimann
authors.forename: S K
authors.initials: SK
authors.lastname: Gibran
authors.forename: C
authors.initials: C
authors.lastname: Groenewald
authors.forename: I A
authors.initials: IA
authors.lastname: Pearce
authors.forename: D
authors.initials: D
authors.lastname: Wong
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D020127:Recovery of Function / Q000187:drug effects*; D012827:Silicone Oils / Q000008:administration & dosage*; D016896:Treatment Outcome; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D018630:Vitreoretinopathy, Proliferative / Q000150:complications* / Q000188:drug therapy*
chemical_list: D009883:Ophthalmic Solutions; D012827:Silicone Oils; C539718:densiron-68