title: Brown-Séquard syndrome secondary to spontaneous bleed from postradiation cavernous angiomas.
abstract: The spontaneous occurrence of acute Brown-Séquard syndrome is an extremely rare event, with most reported cases being secondary to spontaneous epidural hematomas and spinal cord ischemia. We report a rare case of Brown-Séquard syndrome from spontaneous intraspinal hemorrhage in a patient with multiple cavernous angiomas in the spinal cord secondary to craniospinal radiation in childhood. Postulated mechanisms leading to the condition include postradiation molecular changes and venous occlusion.
authors.affiliation: Department of Neurological Surgery, University of California Irvine, Irvine, Calif, USA. mmathews@uci.edu
authors.forename: M S
authors.initials: MS
authors.lastname: Mathews
authors.forename: W W
authors.initials: WW
authors.lastname: Peck
authors.forename: M
authors.initials: M
authors.lastname: Brant-Zawadzki
mesh_terms: D000328:Adult; D018437:Brown-Sequard Syndrome / Q000175:diagnosis* / Q000209:etiology*; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000209:etiology*; D006392:Hemangioma, Cavernous / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000150:complications* / Q000175:diagnosis; D011878:Radiotherapy / Q000009:adverse effects*