Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experiments.
Recent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the aim of this study to address this issue and in doing so, gain understanding on how alcohol-induced effects may be avoided. In this study, tramadol release from Ultram ER tablets and T-long capsules was significantly increased in the presence of ethanol. Conversely, a decrease in the rate of tramadol release was seen from Tridural extended-release tablets in the presence of alcohol.
Traynor
M J
MJ
School of Pharmacy, University of Hertfordshire, Hatfield, Hertfordshire, UK. m.j.traynor@herts.ac.uk
Brown
M B
MB
Pannala
A
A
Beck
P
P
Martin
G P
GP
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D006207:Half-Life; D013607:Tablets; D014147:Tramadol / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000701:Analgesics, Opioid; D002214:Capsules; D003692:Delayed-Action Preparations; D013607:Tablets; D014147:Tramadol; D000431:Ethanol