Relationship between clinical examination, quality of life, disability and depression in CMT patients: Italian multicenter study.
OBJECTIVE
To assess which are the clinical examination tests that are more related to quality of life (QoL), depression, and disability in CMT patients.


METHODS
Large prospective multicenter study through the use of validated clinical, disability, and QoL measurements. Correlations between clinical pattern and disability/QoL and depression were studied.


METHODS
Departments of Neurology.


METHODS
211 CMT patients (60% females, mean age 42.5 years).


METHODS
None.


RESULTS
Sensory function was related to both mental and physical aspects of patient's QoL. Ability to walk on toes and heels was related to physical aspects of QoL/disability but also to bodily pain. Strength of forearm/hand intrinsic muscles was related to disability and physical aspects of QoL.


CONCLUSIONS
Some clinical tests may be better outcome measures than others because they are related to aspects of life highly relevant to the patients. This information may be useful in clinical practice and in clinical trials to infer the patient's QoL.
Padua
L
L
Institute of Neurology, Università Cattolica, Roma, Italy. lpadua@rm.unicatt.it
Aprile
I
I
Cavallaro
T
T
Commodari
I
I
Pareyson
D
D
Quattrone
A
A
Rizzuto
N
N
Vita
G
G
Tonali
P
P
Schenone
A
A
D000203:Activities of Daily Living / Q000523:psychology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002607:Charcot-Marie-Tooth Disease / Q000453:epidemiology* / Q000523:psychology*; D002648:Child; D003866:Depressive Disorder / Q000453:epidemiology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D010525:Peripheral Nerves / Q000503:physiopathology; D011237:Predictive Value of Tests; D011788:Quality of Life / Q000523:psychology*; D015203:Reproducibility of Results; D012678:Sensation Disorders / Q000453:epidemiology / Q000523:psychology