Association of ERCC1 polymorphisms and susceptibility to nasopharyngeal carcinoma.
The normal function of excision repair cross complementing group 1 (ERCC1) is essential for maintaining genomic integrity and preventing cellular neoplastic transformation, and multiple studies have reported an association between ERCC1 polymorphisms and increased risk of cancers. To test whether the genetic variants of ERCC1 gene modify the risk of nasopharyngeal carcinoma (NPC), we compared the 8092 C > A and 19007 C > T single nucleotide polymorphisms (SNPs) and the haplotypes of ERCC1 between 267 patients with NPC and 304 healthy controls. Linkage disequilibrium was observed between the two SNPs loci (D' = 0.861). Significant differences of allele frequencies were found for ERCC1 8092C > A between the cases and controls. Individuals with 8092 C allele showed 1.411-fold (OR = 1.411, 95% CI, 1.076-1.850, P = 0.014) increased risk of developing NPC, and the CC haplotype was associated with a significantly increased risk of NPC (OR = 1.712; 95% CI, 1.211-2.421; P = 0.013). No interactions were found between 8092C > A polymorphism and genders, smoking status and alcohol consumption. These results suggested that the polymorphism of ERCC1 8092 C > A might be a contributing factor in the development of NPC in Chinese population.
Yang
Zhi-Hui
ZH
Department of Pathology, Luzhou Medical College, Luzhou, Sichuan, China.|Department of Forensic Biology, College of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China.
Dai
Qiong
Q
Department of human anatomy, Luzhou Medical College, Luzhou, Sichuan, China.
Kong
Xiang-Li
XL
State Key Laboratory of oral Diseases, Chengdu, Sichuan, China.
Yang
Wen-Li
WL
Department of Biochemistry and Molecular Biology, Luzhou Medical College, Luzhou, Sichuan, China.
Zhang
Lin
L
Department of Forensic Biology, College of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China.
D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004268:DNA-Binding Proteins / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking
D004268:DNA-Binding Proteins; C071447:ERCC1 protein, human; D004720:Endonucleases