title: The prokinetic effect of mosapride citrate on horse gastric emptying rates.
abstract: The prokinetic effect of the 5-HT4 receptor agonist mosapride was evaluated in seven healthy thoroughbreds. Mosapride was orally administered at doses of 0.5, 1.0 or 1.5 mg/kg. The breath 13CO2/12CO2 rate (Delta13CO2), an indirect indicator for the rate of gastric emptying, was measured at appropriate points for 4 hr after drug administration. There was a significant increase compared with the control value at 15, 20 and 165 min for 0.5 mg/kg, 30 min at 1.0 mg/kg and 165 min for 1.5 mg/kg. The results suggest that mosapride may facilitate the gastric emptying in horses.
authors.affiliation: The United Graduate School of Veterinary Sciences, Gifu University, Gifu-shi, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Okamura
authors.forename: Naoki
authors.initials: N
authors.lastname: Sasaki
authors.forename: Morito
authors.initials: M
authors.lastname: Fukunaka
authors.forename: Haruo
authors.initials: H
authors.lastname: Yamada
authors.forename: Hisashi
authors.initials: H
authors.lastname: Inokuma
mesh_terms: D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D001944:Breath Tests; D002245:Carbon Dioxide / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D005746:Gastric Emptying / Q000187:drug effects* / Q000502:physiology; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006736:Horses / Q000502:physiology*; D009025:Morpholines / Q000494:pharmacology*
chemical_list: D001549:Benzamides; D005765:Gastrointestinal Agents; D009025:Morpholines; D002245:Carbon Dioxide; C062720:mosapride