Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
Acrylamide exposure was investigated in subgroups of the EPIC study population (510 subjects from 9 European countries, randomly selected and stratified by age, gender, and smoking status) using hemoglobin adducts of acrylamide (HbAA) and its primary metabolite glycidamide (HbGA). Blood samples were analyzed for HbAA and HbGA by HPLC/MS/MS. Statistical models for HbAA and HbGA were developed including body mass index (BMI), educational level, and physical activity. A large variability in acrylamide exposure and metabolism between individuals and country groups was observed with HbAA and HbGA values ranging between 15-623 and 8-377 pmol/g of Hb, respectively. Both adducts differed significantly by country, sex, and smoking status. HbGA values were significantly lower in high alcohol consumers than in moderate consumers. With increasing BMI, HbGA in nonsmokers and HbAA in smokers decreased significantly. In the assessment of potential health effects related to acrylamide exposure, country of origin, BMI, alcohol consumption, sex, and smoking status should be considered.
Vesper
Hubert W
HW
Centers for Disease Control and Prevention, Atlanta, Georgia, USA. HVesper@cdc.gov
Slimani
Nadia
N
Hallmans
Göran
G
Tjønneland
Anne
A
Agudo
Antonio
A
Benetou
Vassiliki
V
Bingham
Sheila
S
Boeing
Heiner
H
Boutron-Ruault
Marie-Christine
MC
Bueno-de-Mesquita
H Bas
HB
Chirlaque
Dolores
D
Clavel-Chapelon
Françoise
F
Crowe
Francesca
F
Drogan
Dagmar
D
Ferrari
Pietro
P
Johansson
Ingegerd
I
Kaaks
Rudolf
R
Linseisen
Jakob
J
Lund
Eiliv
E
Manjer
Jonas
J
Mattiello
Amalia
A
Palli
Domenico
D
Peeters
Petra H M
PH
Rinaldi
Sabina
S
Skeie
Guri
G
Trichopoulou
Antonia
A
Vineis
Paolo
P
Wirfält
Elisabet
E
Overvad
Kim
K
Strömberg
Ulf
U
D020106:Acrylamide / Q000097:blood* / Q000737:chemistry; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D015992:Body Mass Index; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004781:Environmental Exposure; D004852:Epoxy Compounds / Q000097:blood; D005060:Europe; D005260:Female; D006454:Hemoglobins / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009369:Neoplasms; D009747:Nutritional Physiological Phenomena; D011446:Prospective Studies; D012737:Sex Factors; D012907:Smoking
D004852:Epoxy Compounds; D006454:Hemoglobins; D020106:Acrylamide; C071834:glycidamide