Carriage rate and virulence attributes of oral Candida albicans isolates from patients with oral lichen planus: a study in an ethnic Chinese cohort.
The objectives of this study are to investigate the carriage rate of Candida albicans from the patients with oral lichen planus (OLP, erosive and non-erosive subtypes) and the healthy control individuals in a Chinese cohort and then to compare the virulence attributes of these isolates. Oral C. albicans isolates from 300 patients with OLP as well as 128 healthy controls were isolated and a total of 112 isolates from patients with erosive OLP (62), non-erosive OLP (24) and healthy control (26) were screened for phospholipase activity by using an in vitro plate assay method. Adhesion ability of the above isolates was also studied by using buccal epithelial cells assay. Statistically, the carriage rate of C. albicans from the patients with erosive OLP (44.29%) was higher than that of patients with non-erosive OLP (15.00%) or the healthy control group (20.31%) (P < 0.001). The adhesion to buccal epithelial cells of the isolates from the erosive OLP group (3.950 +/- 1.436) was more marked (P < 0.001) than that from healthy control (2.2112 +/- 0.4833). The phospholipase activity of these isolates either from erosive (0.4170 +/- 0.029) or non-erosive OLP groups (0.4327 +/- 0.028) was higher (P < 0.001) than that from healthy controls (0.5259 +/- 0.074). Some C. albicans isolates with special virulence attributes might be co-factors, which contribute to the development of OLP, especially erosive OLP.
Zeng
Xin
X
State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Hou
Xiaohui
X
Wang
Zhi
Z
Jiang
Lu
L
Xiong
Chunrong
C
Zhou
Min
M
Chen
Qianming
Q
D002176:Candida albicans / Q000201:enzymology / Q000302:isolation & purification* / Q000472:pathogenicity* / Q000502:physiology; D002180:Candidiasis, Oral / Q000453:epidemiology / Q000208:ethnology / Q000382:microbiology; D002353:Carrier State / Q000453:epidemiology / Q000208:ethnology / Q000382:microbiology; D002448:Cell Adhesion; D002681:China / Q000453:epidemiology / Q000208:ethnology; D015331:Cohort Studies; D004847:Epithelial Cells / Q000382:microbiology; D006801:Humans; D017676:Lichen Planus, Oral / Q000453:epidemiology / Q000208:ethnology / Q000382:microbiology; D009061:Mouth Mucosa / Q000166:cytology / Q000382:microbiology; D010740:Phospholipases / Q000378:metabolism; D014774:Virulence
D010740:Phospholipases