Comparative remission rates of schizophrenic patients using various remission criteria.
BACKGROUND
New standardized criteria for remission in schizophrenia were presented in 2005 which need to be examined in regard to their significance for clinical trials.


OBJECTIVE
Data of six antipsychotic drug trials (n=2463) were analyzed by evaluating the proportion of participants who meet the new remission criteria, their symptomatic components, other criteria for remission and simple response-measures (at least 50% Brief Psychiatric Rating Scale (BPRS) reduction and an at least 50% PANSS reduction or a CGI-severity score of "mild or better").


RESULTS
A total of 23.3%/27.2% (last-observation-carried-forward (LOCF)/completer analysis (CO)) of the patients with positive symptoms at baseline met the severity criteria of remission at 4 weeks, 10.5%/20.3% (worst case/CO) met the severity and time criteria at 28 weeks (three studies) and 10.9%/32.4% (worst case/CO) met the severity and time criteria at 52 weeks (one study). At 4 weeks 4.5%/5.5% (LOCF/CO) met the severity criteria when a more stringent severity threshold of "very mild or better" was applied. Absence of symptoms was attained only sporadically. The psychotic symptoms component was met by fewer patients than the negative component. The criteria were more stringent than "at least 50% BPRS reduction" and "CGI-severity score not more than mild" and--for the long-term results--than "at least 50% PANSS reduction". In the short-term analysis, the criteria were less stringent than "at least 50% PANSS reduction".


CONCLUSIONS
The applicability of the severity component of the new criteria in clinical trials was confirmed. The time criterion remains difficult to evaluate.
Beitinger
Romain
R
Department of Psychiatry and Psychotherapy, Technische Universität München, Klinikum rechts der Isar, Möhlstr. 28, 81675 Munich, Germany.
Lin
Jingxia
J
Kissling
Werner
W
Leucht
Stefan
S
D014150:Antipsychotic Agents / Q000627:therapeutic use*; D010054:Brief Psychiatric Rating Scale / Q000592:standards* / Q000706:statistics & numerical data*; D016208:Databases, Factual / Q000706:statistics & numerical data; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012074:Remission Induction; D012559:Schizophrenia / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome
D014150:Antipsychotic Agents