The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation.
Corticosterone facilitates hippocampal glutamate transmission, but the cellular pathways by which AMPA receptor (AMPAR) signaling is adjusted remain elusive. Single quantum-dot imaging in live rat hippocampal neurons revealed that corticosterone triggers, via distinct corticosteroid receptors, time-dependent increases in GluR2-AMPAR surface mobility and synaptic surface GluR2 content. Furthermore, corticosterone potentiates the increase of synaptic surface GluR2 contents by a chemical long-term potentiation stimulus, revealing the influence that corticosterone has on AMPAR trafficking.
Groc
Laurent
L
Physiologie Cellulaire de Synapse, UMR 5091 CNRS, Université Bordeaux 2, Bordeaux 33077, France. laurent.groc@u-bordeaux2.fr
Choquet
Daniel
D
Chaouloff
Francis
F
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002478:Cells, Cultured; D003345:Corticosterone / Q000494:pharmacology / Q000502:physiology*; D004357:Drug Synergism; D018756:GABA Antagonists / Q000494:pharmacology; D005998:Glycine / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D021381:Protein Transport / Q000187:drug effects / Q000502:physiology; D045663:Quantum Dots; D051381:Rats; D018091:Receptors, AMPA / Q000378:metabolism*; D013268:Stimulation, Chemical; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D018756:GABA Antagonists; D018091:Receptors, AMPA; C104722:glutamate receptor ionotropic, AMPA 2; D005998:Glycine; D003345:Corticosterone