title: Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
abstract: Acrylamide exposure was investigated in subgroups of the EPIC study population (510 subjects from 9 European countries, randomly selected and stratified by age, gender, and smoking status) using hemoglobin adducts of acrylamide (HbAA) and its primary metabolite glycidamide (HbGA). Blood samples were analyzed for HbAA and HbGA by HPLC/MS/MS. Statistical models for HbAA and HbGA were developed including body mass index (BMI), educational level, and physical activity. A large variability in acrylamide exposure and metabolism between individuals and country groups was observed with HbAA and HbGA values ranging between 15-623 and 8-377 pmol/g of Hb, respectively. Both adducts differed significantly by country, sex, and smoking status. HbGA values were significantly lower in high alcohol consumers than in moderate consumers. With increasing BMI, HbGA in nonsmokers and HbAA in smokers decreased significantly. In the assessment of potential health effects related to acrylamide exposure, country of origin, BMI, alcohol consumption, sex, and smoking status should be considered.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA. HVesper@cdc.gov
authors.forename: Hubert W
authors.initials: HW
authors.lastname: Vesper
authors.forename: Nadia
authors.initials: N
authors.lastname: Slimani
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Antonio
authors.initials: A
authors.lastname: Agudo
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Benetou
authors.forename: Sheila
authors.initials: S
authors.lastname: Bingham
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Dolores
authors.initials: D
authors.lastname: Chirlaque
authors.forename: Françoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Francesca
authors.initials: F
authors.lastname: Crowe
authors.forename: Dagmar
authors.initials: D
authors.lastname: Drogan
authors.forename: Pietro
authors.initials: P
authors.lastname: Ferrari
authors.forename: Ingegerd
authors.initials: I
authors.lastname: Johansson
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Jakob
authors.initials: J
authors.lastname: Linseisen
authors.forename: Eiliv
authors.initials: E
authors.lastname: Lund
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.forename: Amalia
authors.initials: A
authors.lastname: Mattiello
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Petra H M
authors.initials: PH
authors.lastname: Peeters
authors.forename: Sabina
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Guri
authors.initials: G
authors.lastname: Skeie
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: Elisabet
authors.initials: E
authors.lastname: Wirfält
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Ulf
authors.initials: U
authors.lastname: Strömberg
mesh_terms: D020106:Acrylamide / Q000097:blood* / Q000737:chemistry; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D015992:Body Mass Index; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004781:Environmental Exposure; D004852:Epoxy Compounds / Q000097:blood; D005060:Europe; D005260:Female; D006454:Hemoglobins / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009369:Neoplasms; D009747:Nutritional Physiological Phenomena; D011446:Prospective Studies; D012737:Sex Factors; D012907:Smoking
chemical_list: D004852:Epoxy Compounds; D006454:Hemoglobins; D020106:Acrylamide; C071834:glycidamide