Concise synthesis of indole-fused 1,4-diazepines through copper(I)-catalyzed domino three-component coupling-cyclization-N-arylation under microwave irradiation.
Indole-fused benzo-1,4-diazepines were synthesized by copper-catalyzed domino three-component coupling-indole formation- N-arylation under microwave irradiation from a simple N-mesyl-2-ethynylaniline. This method was also applicable to the formation of heterocycle-fused 1,4-diazepines.
Ohta
Yusuke
Y
Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Chiba
Hiroaki
H
Oishi
Shinya
S
Fujii
Nobutaka
N
Ohno
Hiroaki
H
D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007211:Indoles / Q000737:chemistry* / Q000528:radiation effects*; D008872:Microwaves; D015394:Molecular Structure; D013237:Stereoisomerism
D000814:Aniline Compounds; D001381:Azepines; D007211:Indoles; D003300:Copper; C030374:indole; D000114:Acetylene