Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination.
Sulfotransferases and sulfatases are the major enzymes responsible for sulfate transfer processes. The past two years have seen the elucidation of new functions for these enzymes, and a great progression in their structural characterization, which confirms that these two types of enzymes possess a highly conserved fold. For catalytic activity, sulfatases must contain a formylglycine residue, which is generated by various formylglycine-generating enzymes. Mechanistic and structural details have recently been obtained for a group of cofactor-independent formylglycine-generating enzymes termed FGEs. Finally, an increasing light has been cast upon the mechanism of sulfatase inactivation by a group of clinically important agents, the aryl sulfamates.
Bojarová
Pavla
P
School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melboume, Parkville, Victoria 3010, Australia.
Williams
Spencer J
SJ
D000818:Animals; D055162:Biocatalysis; D005998:Glycine / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D013429:Sulfatases / Q000737:chemistry* / Q000378:metabolism*; D015238:Sulfotransferases / Q000737:chemistry* / Q000378:metabolism*; D013455:Sulfur / Q000737:chemistry* / Q000378:metabolism*
D013455:Sulfur; D015238:Sulfotransferases; D013429:Sulfatases; D005998:Glycine