title: Cycloauration of pyridyl sulfonamides.
abstract: The pyridyl-2-alkylsulfonamides C(5)H(4)N(CH(2))(n)NHSO(2)R (n = 1,2; R = Me, Ph or p-C(6)H(4)Me) and 8-(p-tosylamino)quinoline undergo facile cycloauration reactions with H[AuCl(4)] in water, giving metallacyclic complexes coordinated through the pyridyl (or quinolyl) nitrogen atom and the deprotonated nitrogen of the sulfonamide group. The complexes have been fully characterised by NMR spectroscopy, ESI mass spectrometry and elemental analysis. The X-ray crystal structures of two derivatives reveal the presence of non-planar sulfonamide nitrogen atoms. The complexes show low activity against P388 murine leukaemia cells, possibly as a result of their ease of reduction with mild reducing agents.
authors.affiliation: Department of Chemistry, University of Waikato, Private Bag 3105, Hamilton, New Zealand.
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Kilpin
authors.forename: William
authors.initials: W
authors.lastname: Henderson
authors.forename: Brian K
authors.initials: BK
authors.lastname: Nicholson