Sero-response to measles vaccination at 12 months of age in Saudi infants in Qassim Province.
OBJECTIVE
To evaluate the sero-response to measles component of the first measles, mumps and rubella MMR dose given at 12 months by measuring measles antibody before and one month after the vaccination.


METHODS
A follow-up study where, 57 children at the age of 12 months were recruited randomly from the Primary Health Care Centers in Qassim, Saudi Arabia using a multistage sampling techniques. Fieldwork was conducted from October until December 2006. Blood samples were collected to measure measles IgG antibody before, and one month after giving MMR using enzyme linked immunosorbent assay. Data were compared before and after vaccination using geometric mean titer GMT and seroconversion.


RESULTS
In the 57 infants, positivity rate increased significantly from 3.5% (2/57) pre-vaccination to 100% one month after p=0.0001, and with a sero-conversion of 96.5% (55/57). Also, GMT increased significantly from 0.014-2.172 IU/ML, after vaccination p=0.0001.


CONCLUSIONS
Sero conversion and GMT are significantly high after the first MMR given at 12 months and this is supported by the surveillance data in Qassim.
Khalil
Mohamed K
MK
Medical Research Department, Ministry of Health, Riyadh, Kingdom of Saudi Arabia. statkhl@hotmail.com
Nadrah
Hesham M
HM
Al-Yahia
Omer A
OA
Al-Saigul
Abdulla M
AM
D000914:Antibodies, Viral / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D007115:Immunization Schedule; D007074:Immunoglobulin G / Q000097:blood*; D007223:Infant; D008459:Measles virus / Q000276:immunology*; D022542:Measles-Mumps-Rubella Vaccine; D012529:Saudi Arabia
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D022542:Measles-Mumps-Rubella Vaccine