[Biochemical bone resorption markers during the healing of osteoporotic fractures].
BACKGROUND
This study investigated the progression and clinical relevance of biochemical resorption marker values during fracture healing in osteoporosis.


METHODS
In 44 patients with distal radius fractures and 29 patients without fractures, the blood and urine concentrations of pyridinoline (PYD), deoxypyridinoline (DPD), N-telopeptides (NTx), and bone sialoprotein (BSP) were recorded on the day of trauma as well as during further progression. All postmenopausal patients underwent bone density measurement. Accordingly, patients were divided into premenopausal, postmenopausal osteoporotic, and postmenopausal nonosteoporotic groups.


RESULTS
Between the groups, PYD, DPD, and NTx showed significant differences in their initial values. However, their further relative progression was primarily affected by the chosen therapy.


CONCLUSIONS
Bone resorption markers can diagnostically point to osteoporosis and are significant parameters in fracture healing.
Heiss
C
C
Klinik und Poliklinik für Unfallchirurgie, Universitätsklinikum Giessen-Marburg GmbH, Rudolf-Buchheim-Str. 7, 35385 Giessen, Deutschland. christian.heiss@chiru.med.uni-giessen.de
Hoesel
L M
LM
Pausch
M
M
Meissner
S A
SA
Horas
U
U
Kilian
O
O
Wehr
U
U
Rambeck
W A
WA
Schnettler
R
R
D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D015519:Bone Density / Q000502:physiology; D001862:Bone Resorption / Q000503:physiopathology*; D024042:Collagen Type I / Q000378:metabolism; D005260:Female; D017102:Fracture Healing / Q000502:physiology*; D005598:Fractures, Spontaneous / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D058574:Integrin-Binding Sialoprotein; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology*; D010455:Peptides / Q000378:metabolism; D011885:Radius Fractures / Q000503:physiopathology*; D012016:Reference Values; D012795:Sialoglycoproteins / Q000378:metabolism; D014954:Wrist Injuries / Q000503:physiopathology* / Q000601:surgery
D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; C546871:IBSP protein, human; D058574:Integrin-Binding Sialoprotein; D010455:Peptides; D012795:Sialoglycoproteins; C052929:collagen type I trimeric cross-linked peptide; C015484:pyridinoline; C036020:deoxypyridinoline