title: Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families.
abstract: Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present study based on 626 German familial non-HNPCC colorectal cancer patients and 736 healthy controls. No associations of any of the 10 nsSNPs with colorectal cancer could be replicated. The combined analyses indicated that further research based on additional independent samples is required.
authors.affiliation: Helmholtz-University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Frank
authors.forename: Barbara
authors.initials: B
authors.lastname: Burwinkel
authors.forename: Justo Lorenzo
authors.initials: JL
authors.lastname: Bermejo
authors.forename: Asta
authors.initials: A
authors.lastname: Försti
authors.forename: Kari
authors.initials: K
authors.lastname: Hemminki
authors.forename: Richard
authors.initials: R
authors.lastname: Houlston
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Mangold
authors.forename: Nils
authors.initials: N
authors.lastname: Rahner
authors.forename: Waltraut
authors.initials: W
authors.lastname: Friedl
authors.forename: Nicolaus
authors.initials: N
authors.lastname: Friedrichs
authors.forename: Reinhard
authors.initials: R
authors.lastname: Buettner
authors.forename: Christoph
authors.initials: C
authors.lastname: Engel
authors.forename: Markus
authors.initials: M
authors.lastname: Loeffler
authors.forename: Elke
authors.initials: E
authors.lastname: Holinski-Feder
authors.forename: Monika
authors.initials: M
authors.lastname: Morak
authors.forename: Gisela
authors.initials: G
authors.lastname: Keller
authors.forename: Hans K
authors.initials: HK
authors.lastname: Schackert
authors.forename: Stefan
authors.initials: S
authors.lastname: Krüger
authors.forename: Timm
authors.initials: T
authors.lastname: Goecke
authors.forename: Gabriela
authors.initials: G
authors.lastname: Moeslein
authors.forename: Matthias
authors.initials: M
authors.lastname: Kloor
authors.forename: Johannes
authors.initials: J
authors.lastname: Gebert
authors.forename: Erdmute
authors.initials: E
authors.lastname: Kunstmann
authors.forename: Karsten
authors.initials: K
authors.lastname: Schulmann
authors.forename: Josef
authors.initials: J
authors.lastname: Rüschoff
authors.forename: Peter
authors.initials: P
authors.lastname: Propping
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D015203:Reproducibility of Results