title: Relevance of basal serum FSH to IVF outcome varies with patient age.
abstract: Live birth rate (LBR), age and basal serum FSH values were analysed in 1589 women undergoing their first cycle of IVF. Four age groups (<30, 30-34, 35-38, 39-45 years) and three FSH groups (<5, 5-9.9, > or =10 IU/l) were established. Logistic regression analysis was used to determine the effect of age and FSH on live birth. A model to predict the probability of a live birth suggests that an additional 10 years of age reduces the odds for live birth (OR = 0.66, 95% CI 0.48-0.91); an increase of FSH by 5 IU/l reduces the probability of live birth (OR = 0.75, 95% CI 0.61-0.92); women > or =39 years have an additional reduction in probability of live birth (OR = 0.58, 95% CI 0.61-0.92). Analysis by age and FSH categories showed that pregnancy rate (PR) did not change significantly with rising FSH for women <35 years old. In cycles started with serum FSH <5 IU/l, increasing age did not effect PR and LBR. Cycles started with serum FSH > or =10 IU/l had a PR and LBR of 23.6 and 16.9% respectively. The clinical relevance of elevated FSH varies according to age; younger women with elevated FSH and older women with low FSH still have an acceptable LBR.
authors.affiliation: Barts and the London Centre for Reproductive Medicine, St Bartholomew's and the London Hospital NHS Trust, Kenton and Lucas Wing, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BB, UK. Luca.Sabatini@bartsandthelondon.nhs.uk
authors.forename: L
authors.initials: L
authors.lastname: Sabatini
authors.forename: A
authors.initials: A
authors.lastname: Zosmer
authors.forename: E M
authors.initials: EM
authors.lastname: Hennessy
authors.forename: A
authors.initials: A
authors.lastname: Tozer
authors.forename: T
authors.initials: T
authors.lastname: Al-Shawaf
mesh_terms: D000328:Adult; D000367:Age Factors; D001723:Birth Rate; D004958:Estradiol / Q000378:metabolism; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008875:Middle Aged; D016017:Odds Ratio; D011247:Pregnancy; D011256:Pregnancy Outcome; D016896:Treatment Outcome
chemical_list: D004958:Estradiol; D005640:Follicle Stimulating Hormone