title: A solid phase parallel synthesis of diverse amides as dopamine D3 receptor ligands.
abstract: A solid phase parallel synthesis using SynPhase technology was used to couple a series of 21 carboxylic with three different 4-(4-arylpiperazinyl)butanamines. The resulting library was evaluated as dopamine D(3) receptor ligands giving rise to several compounds with affinities in the low nanomolar concentration range (9e and 9n with binding affinities at D(3) receptors of 0.10 and 0.35 nM respectively).
authors.affiliation: UPRES EA 4090, Substances licheniques et photoprotection, Faculte des Sciences Biologiques et Medicales, Universite de Rennes I, Rennes, France.
authors.forename: Mickaël
authors.initials: M
authors.lastname: Jean
authors.forename: Jacques
authors.initials: J
authors.lastname: Renault
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Camelin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Levoin
authors.forename: Denis
authors.initials: D
authors.lastname: Danvy
authors.forename: Holger
authors.initials: H
authors.lastname: Stark
authors.forename: Marc
authors.initials: M
authors.lastname: Capet
authors.forename: Philippe
authors.initials: P
authors.lastname: Uriac
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D000818:Animals; D002264:Carboxylic Acids / Q000737:chemistry; D006801:Humans; D008024:Ligands; D050637:Receptors, Dopamine D3 / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis*
chemical_list: D000577:Amides; D000588:Amines; D002264:Carboxylic Acids; D008024:Ligands; D050637:Receptors, Dopamine D3; D054852:Small Molecule Libraries