title: Congenital Ewing sarcoma in retroperitoneum with multiple metastases.
abstract: A 7-day-old Japanese female showed the absence of spontaneous movement in her both legs. MRI revealed tumors in the retroperitoneum invading into the spinal canal, the left cerebral hemisphere and the right eyeball. Histological examination of retroperitoneal tumor revealed the sheets of undifferentiated small round cells with hyperchromatic nuclei and scanty cytoplasm. EWS-FLI1 fusion gene was detected by RT-PCR, indicating Ewing sarcoma. She received chemo-radiotherapy and survived for 2 years and 10 months despite the multiple metastases at initial presentation.
authors.affiliation: Department of Pediatrics, Graduate School of Medical sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Saito
authors.forename: Akinobu
authors.initials: A
authors.lastname: Matsuzaki
authors.forename: Aiko
authors.initials: A
authors.lastname: Suminoe
authors.forename: Yuhki
authors.initials: Y
authors.lastname: Koga
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kurata
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Oda
authors.forename: Masazumi
authors.initials: M
authors.lastname: Tsuneyoshi
authors.forename: Toshiro
authors.initials: T
authors.lastname: Hara
mesh_terms: D001932:Brain Neoplasms / Q000556:secondary; D005134:Eye Neoplasms / Q000556:secondary; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D051789:Proto-Oncogene Protein c-fli-1; D034802:RNA-Binding Protein EWS; D012186:Retroperitoneal Neoplasms / Q000151:congenital* / Q000235:genetics / Q000556:secondary*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012512:Sarcoma, Ewing / Q000151:congenital* / Q000235:genetics / Q000473:pathology*; D014157:Transcription Factors / Q000235:genetics
chemical_list: C106031:EWS-FLI fusion protein; D015514:Oncogene Proteins, Fusion; D051789:Proto-Oncogene Protein c-fli-1; D034802:RNA-Binding Protein EWS; D014157:Transcription Factors