[Protective effect of Isodon lophanthoides on acute hepatic injury induced by D-galactosamine in rats].
OBJECTIVE
To study the protective effects of Isodon lophanthoides (ILVG) aqueous extract on acute hepatic injury induced by D-galactosamine (D-Gal) in rats.


METHODS
60 rats were divided into control group, model group, and low, middle, high dosage group, Bifendate group randomly. In test groups, rats received either ILVG aqueous extract (15, 7.5, 3.75 g/kg) or Bifendate (45 mg/kg) by gastric perfusion daily for 7 consecutive days. On the sixth day, D-Gal (550 mg/kg) was given to rats by oral administration. The levels of ALT, AST, ALP, TBA, T-Bil, TP and ALB in serum were analyzed. The weight of body, liver, spleen and thymus of each rat were measured. The hepatic glycogen content was analyzed individually. Liver tissue pathology was observed.


RESULTS
ILVG coud decrease the ALT, AST, ALP, TBA and T-Bil in serum, increase TP, ALB and hepatic glycogen content and restrain the enlargement of liver and the shrinkage of thymus, reduce necrosis in pathological observation.


CONCLUSIONS
ILVG aqueous extract possesses the effect on protecting on acute hepatic injury induced by D-Gal in rats, its effect is related to multifarious mechanism.
Hou
Shao-Zhen
SZ
College of Chinese Drug, Guangzhou University of TCM, Guangzhou 510405, China.
Nagao
Yukiko
Y
Ye
Mu-Rong
MR
Zhu
Chen-Chen
CC
Li
Geng
G
Lai
Xiao-Ping
XP
D000208:Acute Disease; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005688:Galactosamine; D037602:Isodon / Q000737:chemistry*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000097:blood / Q000517:prevention & control*; D008112:Liver Glycogen / Q000096:biosynthesis; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D008112:Liver Glycogen; D020011:Protective Agents; D005688:Galactosamine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin