INH induced status epilepticus: response to pyridoxine.
Isoniazid is an effective and widely used drug in tuberculosis treatment. The administration of toxic amounts of INH causes recurrent seizures, profound metabolic acidosis, coma and even death but therapeutic dose of isoniazid is a very rare cause of seizures. We present a case of 44-year-old HIV positive African-American female who was recently started on a preventive dose of INH after being found purified protein derivative (PPD) positive. She developed status-epilepticus that did not respond to most of the antiepileptics. As soon as she received intravenous pyridoxine, the seizures terminated abruptly.
Tajender
Vasu
V
Department of Medicine, SUNY Upstate Medical University, New York, USA. vasut@upstate.edu
Saluja
Jasjeet
J
D000995:Antitubercular Agents / Q000009:adverse effects*; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D008297:Male; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000188:drug therapy / Q000209:etiology; D011736:Pyridoxine / Q000627:therapeutic use*; D013226:Status Epilepticus / Q000139:chemically induced* / Q000188:drug therapy*; D014803:Vitamin B Complex / Q000627:therapeutic use
D000995:Antitubercular Agents; D014803:Vitamin B Complex; D011736:Pyridoxine; D007538:Isoniazid