Primary mantle-cell non-Hodgkin's lymphoma of the tongue.
The evaluation of tongue swellings often represents a diagnostic challenge, because of the wide spectrum of benign and malignant possible lesions. We report a case of a patient presenting a tongue mass. An incisional biopsy was performed. Diagnosis of primary Mantle Cell non-Hodgkin's Lymphoma of the tongue was made by histological, immunohistochemical and cytogenetic studies. Our patient was treated with Rituximab-Cyclophosphamide, Epirubicine, Vincristine, Prednisone polychemotherapy plus Rituximab as single agent maintenance. Complete remission was achieved and no relapse has occurred during a follow-up of 53 months. We emphasize the importance of including also NHL in differential diagnosis of a tongue mass.
Guastafierro
Salvatore
S
Department of Haematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Naples, Italy.
Falcone
Umberto
U
Department of Haematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Naples, Italy. umberto80@libero.it.|, Via Unità Italiana 52, 81100, Caserta, Italy. umberto80@libero.it.
Celentano
Maria
M
Department of Haematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Naples, Italy.
Cappabianca
Salvatore
S
Department of Radiology, Second University of Naples, Naples, Italy.
Giudice
Amerigo
A
Department of Head and Neck Surgery, Second University of Naples, Naples, Italy.
Colella
Giuseppe
G
Department of Head and Neck Surgery, Second University of Naples, Naples, Italy.
D005260:Female; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D014059:Tongue / Q000473:pathology*; D014062:Tongue Neoplasms / Q000473:pathology*