title: In silico analysis for transcription factors with Zn(II)(2)C(6) binuclear cluster DNA-binding domains in Candida albicans.
abstract: A total of 6047 open reading frames in the Candida albicans genome were screened for Zn(II)(2)C(6)-type zinc cluster proteins (or binuclear cluster proteins) involved in DNA recognition. These fungal proteins are transcription regulators of genes involved in a wide range of cellular processes, including metabolism of different compounds such as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell wall architecture, etc. The selection criteria used in the sequence analysis were the presence of the CysX(2)CysX(6)CysX(5-16)CysX(2)CysX(6-8)Cys motif and a putative nuclear localization signal. Using this approach, 70 putative Zn(II)(2)C(6) transcription factors have been found in the genome of C. albicans.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Universitat de València, Burjassot, Valencia 46100, Spain.
authors.forename: Sergi
authors.initials: S
authors.lastname: Maicas
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Moreno
authors.forename: Almudena
authors.initials: A
authors.lastname: Nieto
authors.forename: Micaela
authors.initials: M
authors.lastname: Gómez
authors.forename: Rafael
authors.initials: R
authors.lastname: Sentandreu
authors.forename: Eulogio
authors.initials: E
authors.lastname: Valentín