title: A highly diastereo- and enantioselective synthesis of multisubstituted cyclopentanes with four chiral carbons by the organocatalytic domino Michael-Henry reaction.
abstract: Highly functionalized cyclopentanes with four stereogenic carbons including two quaternary stereocenters have been synthesized in excellent yields (90-95%) with complete diastereoselectivities and excellent enantioselectivities (88-96% ee) by the organocatalyzed asymmetric domino Michael-Henry reaction.
authors.affiliation: Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
authors.forename: Bin
authors.initials: B
authors.lastname: Tan
authors.forename: Pei Juan
authors.initials: PJ
authors.lastname: Chua
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zeng
authors.forename: Min
authors.initials: M
authors.lastname: Lu
authors.forename: Guofu
authors.initials: G
authors.lastname: Zhong
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D005027:Ethylene Oxide / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D014050:Toluene / Q000737:chemistry*
chemical_list: D003517:Cyclopentanes; D014050:Toluene; D002244:Carbon; D005027:Ethylene Oxide