title: Mosquito larvicidal activity of isolated compounds from the rhizome of Zingiber officinale.
abstract: The larvicidal activity of a petroleum ether extract of Zingiber officinale Roscoe (Zingiberaceae) was evaluated against Aedes aegypti L. and Culex quinquefasciatus Say (Diptera). Bioassay-guided fractionation led to the isolation of 4-gingerol (1), (6)-dehydrogingerdione (2) and (6)-dihydrogingerdione (3); the latter has not previously been reported from Z. officinale. The structures were established from infrared (IR), ultraviolet (UV), (1)H-nuclear magnetic resonance (NMR), (13)C-NMR and mass spectral data. Following a 24 h exposure, compounds 1-3 exhibited larvicidal activities against fourth instar larvae of A. aegypti (LC(50) 4.25, 9.80, 18.20 ppm) and C. quinquefasciatus (LC50 5.52, 7.66, 27.24 ppm), respectively. The results show that the most effective compound was 4-gingerol.
authors.affiliation: Unit of Bioactive Natural Products, Department of Zoology, C. Abdul Hakeem College, Melvisharam 632 509, India. abdulrahuman6@hotmail.com
authors.forename: A Abdul
authors.initials: AA
authors.lastname: Rahuman
authors.forename: Geetha
authors.initials: G
authors.lastname: Gopalakrishnan
authors.forename: P
authors.initials: P
authors.lastname: Venkatesan
authors.forename: Kannappan
authors.initials: K
authors.lastname: Geetha
authors.forename: A
authors.initials: A
authors.lastname: Bagavan
mesh_terms: D000330:Aedes / Q000187:drug effects* / Q000254:growth & development; D000818:Animals; D005591:Chemical Fractionation; D003465:Culex / Q000187:drug effects* / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D020939:Zingiber officinale / Q000737:chemistry*; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry
chemical_list: D007306:Insecticides; D010936:Plant Extracts