Deconstructing export of malaria proteins.
The virulence of the malaria parasite Plasmodium falciparum is mediated by parasite proteins exported to the surface of infected erythrocytes. In this issue, Maier et al. (2008) report a screen of malaria parasite genes predicted to be involved in parasite protein export and trafficking within the host erythrocyte and discover that many more than expected are essential for parasite survival in vitro.
Bonnefoy
Serge
S
Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, 75724 Paris Cedex 15, France.
Ménard
Robert
R
D000818:Animals; D004910:Erythrocyte Membrane / Q000737:chemistry; D004912:Erythrocytes / Q000166:cytology / Q000469:parasitology*; D006801:Humans; D008288:Malaria; D010963:Plasmodium falciparum / Q000235:genetics / Q000472:pathogenicity*; D021381:Protein Transport; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D014774:Virulence
D015800:Protozoan Proteins