title: Hypolipidemic effect in cholesterol-fed rats of a soluble fiber-rich product obtained from cocoa husks.
abstract: A new soluble cocoa fiber product (SCFP), obtained after enzymatic treatment of cocoa husks, was characterized and its potential health effects studied in an animal model of dietary-induced hypercholesterolemia. The SCFP was rich in soluble dietary fiber (DF) and antioxidant polyphenols. Consumption of a cholesterol-rich diet containing the SCFP as a source of DF resulted in lower food intake and body weight gain in comparison with control groups consuming cholesterol-free or cholesterol-rich diets with cellulose as DF. The cholesterol-rich diet caused remarkable hypercholesterolemia. However, the SCFP diminished the negative impact of the cholesterol-rich diet, buffering the decrease of high density lipoprotein-cholesterol, and the increase of total and low density lipoprotein-cholesterol levels, and lipid peroxidation (malondialdehyde levels) induced by the fatty diet. The SCFP also decreased triglyceride levels to values lower than those in the group fed the cholesterol-free diet. These results put forward the potential application of the SCFP as a dietary supplement or functional food ingredient.
authors.affiliation: Department of Metabolism and Nutrition, Instituto del Frio, Spanish Council for Scientific Research (CSIC), C/ Jose Antonio Novais 10, 28040 Madrid, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Ramos
authors.forename: Leila
authors.initials: L
authors.lastname: Moulay
authors.forename: Ana Belén
authors.initials: AB
authors.lastname: Granado-Serrano
authors.forename: Olga
authors.initials: O
authors.lastname: Vilanova
authors.forename: Begoña
authors.initials: B
authors.lastname: Muguerza
authors.forename: Luis
authors.initials: L
authors.lastname: Goya
authors.forename: Laura
authors.initials: L
authors.lastname: Bravo
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000032:analysis; D002099:Cacao / Q000737:chemistry*; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004043:Dietary Fiber / Q000008:administration & dosage* / Q000032:analysis; D005419:Flavonoids / Q000008:administration & dosage / Q000032:analysis; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D012995:Solubility
chemical_list: D000975:Antioxidants; D002791:Cholesterol, Dietary; D004043:Dietary Fiber; D005419:Flavonoids; D000960:Hypolipidemic Agents; D008055:Lipids; D008315:Malondialdehyde