title: Increased glycated albumin and decreased esRAGE concentrations are associated with in-stent restenosis in Chinese diabetic patients.
abstract: BACKGROUND
  We investigated the impact of glycated albumin (GA) and endogenous secretory receptor for advanced glycation end products (esRAGE) and RAGE polymorphisms on occurrence of in-stent restenosis (ISR) in Chinese patients with type 2 diabetes.
  
  
  METHODS
  Four hundred nineteen patients with diabetes were divided, based upon the presence or absence of coronary artery disease (CAD) and ISR, into Group I (205 patients without CAD), Group II (128 patients with CAD but without ISR) and Group III (86 patients with ISR). One hundred fifty-two normal subjects were served as controls. Serum concentrations of GA and esRAGE were measured, and RAGE polymorphisms (-374T>A, -429T>C and G82S) were analyzed.
  
  
  RESULTS
  Serum GA concentration was higher and, in contrast, esRAGE concentration was lower in Group III than in the other groups (P<0.05). These two protein concentrations correlated closely with loss index (all P<0.01), and were independent risk factors for ISR in diabetic patients (P=0.01 and P=0.025, respectively). However, there were no differences in the allele and genotype frequencies in the 3 polymorphisms of RAGE gene between groups.
  
  
  CONCLUSIONS
  Increased GA and decreased esRAGE concentrations, but not -374T>A, -429T>C and Gly82Ser polymorphisms of RAGE gene, are associated with ISR in Chinese patients with type 2 diabetes.
authors.affiliation: Department of Cardiology, Rui Jin Hospital, Institute of Cardiovascular Diseases, Jiaotong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.forename: Li
authors.initials: L
authors.lastname: Jin Pu
authors.forename: Qiu Jing
authors.initials: QJ
authors.lastname: Chen
authors.forename: Linjie
authors.initials: L
authors.lastname: Wang
authors.forename: Wenhui
authors.initials: W
authors.lastname: Peng
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Yan
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Yan Zhang
authors.forename: Pei Hua
authors.initials: PH
authors.lastname: Gong
authors.forename: Jian Ping
authors.initials: JP
authors.lastname: Qiu
authors.forename: Wei Feng
authors.initials: WF
authors.lastname: Shen
mesh_terms: D000368:Aged; D002681:China / Q000453:epidemiology; D023903:Coronary Restenosis / Q000097:blood* / Q000150:complications* / Q000453:epidemiology; D048909:Diabetes Complications / Q000097:blood* / Q000453:epidemiology; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism*; D015607:Stents; D000093423:Glycated Serum Albumin
chemical_list: D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin