title: [Studies on chemical constituents of Sarcandra glabra].
abstract: OBJECTIVE
  To study antibacterial chemical constituents of Sarcandra glabra.
  
  
  METHODS
  The constituents of the chloroform and EtOAc-soluble portions of the EtOH extract from the whole plant of S. glabra, which posses the antibacterial activities, were isolated and purified with column chromatography. The compounds were identified by physical and spectroscopic techniques.
  
  
  RESULTS
  Six compounds were isolated and identified as 4, 4'-biisofraxidin (1), esculetin (2), fraxetin (3), scoparone (4), isofraxidin (5), scopoletin(6), respectively.
  
  
  CONCLUSIONS
  Compound 1 is a novel natural product. Compounds 24 were isolated from the plants of Chloranthaceae for the first time. The antibacterial activities of these six compounds were tested for the first time. Some compounds may have potential for future study and development as plant-derived oral antibacterial agents.
authors.affiliation: Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100094, China. xdxu@implad.ac.cn
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Xu
authors.forename: Xiao-Ru
authors.initials: XR
authors.lastname: Hu
authors.forename: Jing-Quan
authors.initials: JQ
authors.lastname: Yuan
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Yang
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D016966:Porphyromonas gingivalis / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013295:Streptococcus mutans / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D003374:Coumarins; D004365:Drugs, Chinese Herbal