title: Intracranial aneurysms in sickle cell patients: report of 2 cases and review of the literature.
abstract: BACKGROUND
  The sickle cell disease has different neurologic complications, including cerebral aneurysms. This disease may lead to endothelial damage, which favors the development of cerebral aneurysms. Only a few cases demonstrated by cerebral angiography or surgery have been reported in the English literature referring to cerebral aneurysms in sickle cell patients.
  
  
  METHODS
  We report 2 patients with sickle cell disease whose cerebral aneurysms were successfully treated by open surgery.
  
  
  CONCLUSIONS
  Sickle cell patients have a high occurrence of multiple aneurysms, and a high prevalence of posterior circulation aneurysms. This must be interpreted with caution, and further studies are needed to confirm this association.
authors.affiliation: Department of Neurosurgery, Santa Casa Hospital, Faculty of Medical Science of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. rafabrand@gmail.com
authors.forename: Rafael Augusto Castro Santiago
authors.initials: RA
authors.lastname: Brandão
authors.forename: Gervásio Teles C
authors.initials: GT
authors.lastname: de Carvalho
authors.forename: Baltazar Leão
authors.initials: BL
authors.lastname: Reis
authors.forename: Enderson
authors.initials: E
authors.lastname: Bahia
authors.forename: Atos Alves
authors.initials: AA
authors.lastname: de Souza
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D002533:Cerebral Angiography; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000209:etiology* / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome