[Electrochemical behaviour of the adriamycin on the cobalt nanoparticles modified ITO electrode].
A cobalt nanoparticles modified ITO electrode (NpCo/ITO) was prepared by casting cobalt nanoparticles onto ITO electrode and the cobalt nanoparticles were synthesized by NaHB4 reduction. The electrochemical behaviors of adriamycin (ADM) on NpCo/ITO were studied. The modified ITO electrode was characterized by cyclic voltammetry (CV), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). In a 0.01 mol L(-1) PBS (pH 8.0) buffer solution, a sensitive reduction peak of ADM was obtained. A linear relationship is held between the peak current and ADM concentration in the range of 1.0 x 10(-8) - 2.0 x 10(-6) mol L(-1) with detection of 5.0 x 10(-9) mol L(-1)- by cyclic voltammetry (CV) response. The reduction process was irreversible with adsorption at the NpCo/ITO electrode. The modified electrode showed an excellent electrocatalytic activity for the ADM electrochemical reduction.
Gong
Lan-Xin
LX
School of Life Science and Chemistry, Xinjiang Normal University, Urumchi 830054, China.
Wei
Cui-Mei
CM
Hu
Jin-Bo
JB
Li
Qi-Long
QL
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D019411:Clinical Laboratory Techniques; D003035:Cobalt / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry* / Q000494:pharmacology; D004563:Electrochemistry; D004566:Electrodes / Q000639:trends*; D053758:Nanoparticles / Q000737:chemistry*
D000970:Antineoplastic Agents; D003035:Cobalt; D004317:Doxorubicin