Metalloproteinase's activity and oxidative stress in mild cognitive impairment and Alzheimer's disease.
Matrix metalloproteinases (MMPs) and oxidative stress have been implicated in neurological diseases such as Alzheimer's disease (AD). Plasma MMP-2 and MMP-9 activities were assessed in Mild Cognitive Impairment (MCI) and AD subjects compared with aged-matched controls, and subsequently analysed in relation to oxidative stress markers. Both MMP-2 and MMP-9 showed no significant changes versus control subjects. Plasma glutathione peroxidase Se-dependent (GPx-Se) activity and malondialdehyde (MDA) levels were higher in AD than in controls (P < 0.05), suggesting a role for GPx-Se in controlling oxidative stress in AD. Negative correlations were observed between MMPs and MDA in AD and MCI patients (P < 0.05). In conclusion, oxidative stress events did not include activation of MMPs and this similar pattern in AD and MCI suggests that both are biochemically equivalent.
Martín-Aragón
Sagrario
S
Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, Avenida de la Complutense s/n, 28040, Madrid, Spain. smartina@farm.ucm.es
Bermejo-Bescós
Paloma
P
Benedí
Juana
J
Felici
Emanuela
E
Gil
Pedro
P
Ribera
José Manuel
JM
Villar
Angel Ma
AM
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology / Q000378:metabolism*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000201:enzymology / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006801:Humans; D008315:Malondialdehyde / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D018384:Oxidative Stress
D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D020782:Matrix Metalloproteinases