Concept and computational design for a bioartificial nephron-on-a-chip.
A MEMS-based, (Micro Electro Mechanical System) bioartificial device is proposed for replicating the function of a single nephron. Consistent with the anatomy and physiology of humans, our device has 3 distinct sections, replicating the function of the glomerulus, the proximal tubule, and the loop of Henle. Construction of a bioartificial loop of Henle in particular requires control of diffusion-scale features. The proposed device can be built using existing microfabrication technologies and populated with various renal cell types. A computational model is also developed to analyze the coupled, multiphase mass transport in this system. Using the model, a design is generated with flow and solute transport properties matching those of the human nephron.
Weinberg
E
E
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Kaazempur-Mofrad
M
M
Borenstein
J
J
D019295:Computational Biology; D007688:Kidneys, Artificial; D056656:Lab-On-A-Chip Devices; D009399:Nephrons / Q000166:cytology*; D054457:Tissue Scaffolds