Treatment of extra-abdominal aggressive fibromatosis with pegylated interferon.
Aggressive fibromatosis (desmoid tumor) is a very rare neoplasm arising from the musculoaponeurotic structures. It is characterized by locally aggressive growth, and a tendency to relapse but not to metastasize. We report on a young woman with a large desmoid tumor of the left foot. Multiple operations and radiotherapy had resulted in local recurrences. Long-term immunointervention with pegylated interferon alfa-2b, however, led to marked clinical improvement of the patient's condition and a radiologically proven stabilization of the disease.
Stengel
Gabriele
G
Department of Dermatology, University of Münster, Münster, Germany.
Metze
Dieter
D
Dörflinger
Bernd
B
Luger
Thomas A
TA
Böhm
Markus
M
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001706:Biopsy; D005260:Female; D018222:Desmoid Tumors / Q000188:drug therapy* / Q000473:pathology; D005528:Foot; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D011092:Polyethylene Glycols; D011994:Recombinant Proteins; D012720:Severity of Illness Index; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C417083:peginterferon alfa-2b