title: John Eccles (1903-97) and the experiment that proved chemical synaptic transmission in the central nervous system.
abstract: One of the most important experiments in neurophysiology in the twentieth century took place in the physiology laboratories at the University of Otago, New Zealand, in August 1951. The group of researchers led by John Eccles convincingly established that synaptic transmission in the central nervous system was a chemical process. This work was the culmination of a long debate between advocates of electrical and chemical transmission. The conclusions overturned Eccles's previous theories of an electrical "Golgi-cell" mechanism and represent a pivotal moment in the history of neuroscience.
authors.affiliation: School of Medicine, University of Queensland, Brisbane, Queensland 4000, Australia. drtodman@optusnet.com.au
authors.forename: Don
authors.initials: D
authors.lastname: Todman
mesh_terms: D000046:Academic Medical Centers / Q000266:history; D000818:Animals; D001315:Australia; D002531:Cerebellum / Q000166:cytology / Q000502:physiology; D003299:Cooperative Behavior; D004594:Electrophysiology / Q000379:methods; D049673:History, 20th Century; D006801:Humans; D007393:International Educational Exchange / Q000266:history; D009445:Neuroanatomy / Q000266:history*; D009482:Neurophysiology / Q000266:history*; D009520:New Zealand; D009435:Synaptic Transmission / Q000502:physiology*; D014481:United States