[Study on preparation of glycyrrhiza total flavones effective components sustained-release pellets and its properties].
OBJECTIVE
To prepare the glycyrrhiza total flavones effective components pellets by extrusion-spheronization, and to optimize the formulation of glycyrrhiza total flavones effective components sustained release pellets coated with mixed Eudragit RS 100.


METHODS
The sustained-release pellets of glycyrrhiza total flavones were prepared by Glatt fluid bed technique. The factors influencing the drug release behaviors and their properties were evaluated.


RESULTS
The optimal drug sustained-release was shown at the loading weight of copolymers of 6% and the plasticizer concentration of 10%. And the curves of cumulative drug release were fit for Peppas and Higuchi equation.


CONCLUSIONS
The pellets show obviously sustained-release effect.
Chen
Li-Hua
LH
Shanghai University of TCM, Shanghai 201203, China. chlly98@163.com
Feng
Yi
Y
Xu
De-Sheng
DS
Li
Jun-Song
JS
Zhang
Liang
L
Wang
Yi-Han
YH
D000180:Acrylic Resins; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000493:pharmacokinetics; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000493:pharmacokinetics; D000431:Ethanol / Q000737:chemistry; D005079:Excipients / Q000737:chemistry; D047309:Flavones / Q000737:chemistry* / Q000493:pharmacokinetics; D006035:Glycyrrhiza / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D005079:Excipients; D047309:Flavones; D011108:Polymers; D013607:Tablets; C050528:Eudragit RS; D000431:Ethanol; D011092:Polyethylene Glycols