Antidiabetic effect of an active fraction extracted from dragon's blood (Dracaena Cochinchinensis).
The active fraction extracted from dragon's blood displayed an inhibitory effect on alpha-glucosidase activity with an IC50 of 0.152 microg/mL, which is nearly half of the crude material. Its inhibition on alpha-glucosidase was noncompetitive. In addition, when this fraction was orally administered to mice dosed with Acarbose (20 mg/kg), the active fraction (100, 300, 500 mg/kg) significantly suppressed increase of blood glucose levels after sucrose loading in a dose-dependent manner. These results suggest that this extract from dragon's blood exerts an anti-diabetic effect by suppressing intestinal carbohydrate absorption and thereby reducing the postprandial increase of blood glucose.
Gu
Hui-Juan
HJ
School of Life Sciences, Shanghai University, Shanghai, China.
Lv
Jing-Ci
JC
Yong
Ke-Lan
KL
Chen
Xu
X
Liu
Pei-Pei
PP
Zhang
Xia-Bing
XB
D020909:Acarbose; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D050260:Carbohydrate Metabolism / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D031409:Dracaena / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000302:isolation & purification*; D007408:Intestinal Absorption; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*
D001786:Blood Glucose; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D020909:Acarbose