Oleanolic acid and related derivatives as medicinally important compounds.
Oleanolic acid has been isolated from chloroform extract of Olea ferruginea Royle after removal of organic bases and free acids. The literature survey revealed it to be biologically very important. In this review the biological significance of oleanolic acid and its derivatives has been discussed. The aim of this review is to update current knowledge on oleanolic acid and its natural and semisynthetic analogs, focussing on its cytotoxic, antitumer, antioxidant, anti-inflamatory, anti-HIV, acetyl cholinesterase, alpha-glucosidase, antimicrobial, hepatoprotective, anti-inflammatory, antipruritic, spasmolytic activity, anti-angiogenic, antiallergic, antiviral and immunomodulatory activities. We present in this review, for the first time, a compilation of the most relevant scientific papers and technical reports of the chemical, pre-clinical and clinical research on the properties of oleanolic acid and its derivatives.
Sultana
Nighat
N
PCSIR Laboratories Complex, Pharmaceutical Research Center, Karachi, Pakistan. nighat2001us@yahoo.com
Ata
Athar
A
D000818:Animals; D006027:Glycosides / Q000737:chemistry; D006801:Humans; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D004364:Pharmaceutical Preparations; D012503:Saponins / Q000737:chemistry
D006027:Glycosides; D004364:Pharmaceutical Preparations; D012503:Saponins; D009828:Oleanolic Acid