Effect of solvent on enantioselective esterification of naproxen by lipase with trimethylsilyl methanol.
Improvement of stereoselective resolution of racemic Naproxen, 2-(6-methoxy-2-naphthyl)propionic acid, was attempted with esterifcation reaction by Candida cylindracea lipase. By carefully selecting the organic medium, a 72-time enhancement of yield of the desired S-ester was achieved. The optimal reaction temperature was approximately 53 degrees C, and an alcohol concentration between 20 mM and 40 mM in an 80% (v/v) isooctane and 20% (v/v) toluene mixture was found. (c) 1994 John Wiley & Sons, Inc.
Tsai
S W
SW
Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan, R.O.C.
Wei
H J
HJ