Interleukin 8 and 1beta and RANTES levels in esophageal mucosa predict recurrence of endoscopy-negative gastroesophageal reflux disease.
OBJECTIVE
Endoscopy-negative gastroesophageal reflux disease (ENRD), an incipient GERD phenotype without mucosal breaks, is a chronic relapsing condition with an impact on quality of life. Proinflammatory cytokines and chemokines play a role in the pathogenesis of various conditions including GERD.


METHODS
This study investigated the relationship between interleukin 8 (IL-8), monocyte chemoattractant protein 1 (MCP-1), regulated on activation normal T-cell expressed and presumably secreted (RANTES) and IL-1beta levels in esophageal mucosa and recurrence of the reflux symptom in 22 patients with ENRD.


RESULTS
Based on analysis using Cox's proportional hazard regression model, significantly positive association was observed between the mucosal levels of cytokines (IL-8 and -1beta and RANTES) and ENRD recurrence. Otherwise, parameters including age, gender, body mass index, smoking habits, alcohol intake, hiatal hernia and Helicobacter pylori status were not significantly related to relapse of the symptom.


CONCLUSIONS
Enhanced production of such cytokines as IL-8 and -1beta and RANTES in esophageal mucosa can be potential predictors for ENRD recurrence.
Isomoto
Hajime
H
Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan. hajimei2002@yahoo.co.jp
Wang
Aiping
A
Nishi
Yoshito
Y
Matsumoto
Ayako
A
Shikuwa
Saburo
S
Mizuta
Yohei
Y
Inoue
Kenichiro
K
Kohno
Shigeru
S
D000328:Adult; D000368:Aged; D018946:Chemokine CCL5 / Q000032:analysis*; D004947:Esophagus / Q000737:chemistry*; D005260:Female; D005764:Gastroesophageal Reflux / Q000276:immunology*; D006801:Humans; D053583:Interleukin-1beta / Q000032:analysis*; D016209:Interleukin-8 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000737:chemistry; D011237:Predictive Value of Tests; D012008:Recurrence
D018946:Chemokine CCL5; D053583:Interleukin-1beta; D016209:Interleukin-8