Disease associations and family-based tests.
This unit describes the statistical techniques necessary for performing family-based association studies (such as the TDT) for genetic polymorphisms. Such studies have become increasingly important in the identification of genes that confer an increased risk to disease, particularly for common diseases with a complex etiology. The family-based approach avoids some of the problems often encountered when applying the traditional case-control design to genetic studies. The unit includes the Sib TDT (S-TDT) method, which allows application of the principle of the TDT to sibships without parental data, and several related tests.
Ewens
Warren J
WJ
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Spielman
Richard S
RS
Kaplan
Norman L
NL
Gao
Xiaoyi
X
Morris
Richard W
RW
Martin
Eden R
ER
D000483:Alleles; D016022:Case-Control Studies; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D015233:Models, Statistical; D009679:Nuclear Family; D012107:Research Design
D005819:Genetic Markers