title: Effects of mannitol alone and mannitol plus furosemide on renal oxygen consumption, blood flow and glomerular filtration after cardiac surgery.
abstract: OBJECTIVE
  Imbalance of the renal medullary oxygen supply/demand relationship can cause hypoxic medullary damage and ischaemic acute renal failure (ARF). The use of mannitol for prophylaxis/treatment of clinical ischaemic ARF is controversial and the effect of mannitol on renal oxygenation in man has not yet been investigated. We evaluated the effects of mannitol on renal oxygen consumption (RVO(2))(,) renal blood flow (RBF) and glomerular filtration rate (GFR) in postoperative patients.
  
  
  METHODS
  Prospective interventional study.
  
  
  METHODS
  University hospital cardiothoracic ICU.
  
  
  METHODS
  Ten uncomplicated mechanically ventilated and sedated postcardiac surgery patients with preoperatively normal renal function.
  
  
  METHODS
  Mannitol infusion (225 mg/kg + 75 mg/kg/h) and combined mannitol and furosemide infusion (0.25 mg/kg + 0.25 mg/kg/h).
  
  
  RESULTS
  Systemic haemodynamics were evaluated by a pulmonary artery catheter. RBF and GFR were measured by the renal vein thermodilution technique and by renal extraction of (51)Cr-EDTA, respectively. Mannitol increased urine flow (60%), GFR (20%) and filtration fraction (FF) (20%) with no change in RBF. This was accompanied by an increase in renal sodium reabsorption (18%), RVO(2) (19%) and renal oxygen extraction (21%). When combined with mannitol, furosemide normalised sodium reabsorption, RVO(2), renal oxygen extraction with no change in RBF, while GFR and FF were still elevated compared to control.
  
  
  CONCLUSIONS
  In patients with normal renal function, mannitol increases GFR, which increases tubular sodium load, sodium reabsorption and RVO(2) after cardiac surgery. The lack of effect on RBF, indicates that mannitol impairs the renal oxygen supply/demand relationship. Furosemide normalised renal oxygenation when combined with mannitol.
authors.affiliation: Department of Cardiothoracic Anaesthesia and Intensive Care, Sahlgrenska University Hospital, 41345, Göteborg, Sweden.
authors.forename: Bengt
authors.initials: B
authors.lastname: Redfors
authors.forename: Kristina
authors.initials: K
authors.lastname: Swärd
authors.forename: Johan
authors.initials: J
authors.lastname: Sellgren
authors.forename: Sven-Erik
authors.initials: SE
authors.lastname: Ricksten
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy / Q000517:prevention & control*; D006348:Cardiac Surgical Procedures; D004232:Diuretics / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D007362:Intensive Care Units; D008353:Mannitol / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D011446:Prospective Studies; D012079:Renal Circulation / Q000187:drug effects*
chemical_list: D004232:Diuretics; D008353:Mannitol; D005665:Furosemide