The role of the Wilms' tumour-suppressor protein WT1 in apoptosis.
The Wilms' tumour-suppressor gene (WT1), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role in the formation of a paediatric malignancy of the kidneys (Wilms' tumour), it has also emerged as an oncogenic factor influencing proliferation and apoptosis in a large variety of adult cancers. This review focuses on new insights into WT1's role in early development and its potential oncogenic role in adult cancer.
Hartkamp
Jörg
J
Faculty of Life Sciences, The Michael Smith Building, University of Manchester, Oxford Road, Manchester, UK. Joerg.Hartkamp@manchester.ac.uk
Roberts
Stefan G E
SG
D000818:Animals; D017209:Apoptosis; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D025721:WT1 Proteins / Q000235:genetics / Q000378:metabolism*
D015513:Oncogene Proteins; D025721:WT1 Proteins