The mitochondrial proteome: from inventory to function.
Mitochondria are central to cellular energetics, metabolism, and signaling. In this issue, Pagliarini et al. (2008) report the largest compendium of mammalian mitochondrial proteins to date. Together with proteomic studies in yeast, this study represents an important step toward the systematic characterization of the mitochondrial proteome and of mitochondrial diseases.
Meisinger
Chris
C
Institut für Biochemie und Molekularbiologie, ZBMZ, Universität Freiburg, 79104 Freiburg, Germany.
Sickmann
Albert
A
Pfanner
Nikolaus
N
D000818:Animals; D006801:Humans; D013058:Mass Spectrometry; D051379:Mice; D008928:Mitochondria / Q000737:chemistry*; D024101:Mitochondrial Proteins / Q000032:analysis*; D020543:Proteome
D024101:Mitochondrial Proteins; D020543:Proteome