The role of alphoid higher order repeats (HORs) in the centromere folding.
Understanding the folding of centromere DNA in the maximally condensed methaphase chromosome remains a basic challenge in cell biology. We propose here a set of structural models with a graphical presentation of alphoid higher order repeat (HOR) distribution in the centromere folding, based on the assumption of encryption key for microtubule-centromere interaction which arises from chromosome-specific crystal-like structure of HORs. Specific HOR leads to a characteristic geometrical pattern which may be responsible for individual microtubule to recognize a specific structure of centromere in each chromosome.
Rosandić
Marija
M
Department of Internal Medicine, University Hospital Rebro, University of Zagreb, Kispatićeva 12, 10000 Zagreb, Croatia. rosandic@hazu.hr
Gluncić
Matko
M
Paar
Vladimir
V
Basar
Ivan
I
D000465:Algorithms; D001483:Base Sequence; D002503:Centromere / Q000235:genetics*; D019295:Computational Biology; D003198:Computer Simulation; D004247:DNA / Q000235:genetics*; D006801:Humans; D008870:Microtubules / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D016415:Sequence Alignment
D004247:DNA