Cadinane sesquiterpenes from the leaves of Eupatorium adenophorum.
Four new cadinane sesquiterpenes (1- 4), including a dimeric cadinane derivative (2) and a peroxide cadinane analogue (3), have been isolated from the leaves of Eupatorium adenophorum. Their structures including absolute configurations were determined on the basis of spectroscopic data interpretation and single-crystal X-ray crystallography. Compound 4 showed in vitro cytotoxicity against the HCT-8, Bel-7402, and A2780 cancer cell lines.
He
Lan
L
Department of Chemistry, Beijing Normal University, Beijing 100875, People's Republic of China. helan1961@yahoo.com.cn
Hou
Jing
J
Gan
Maoluo
M
Shi
Jiangong
J
Chantrapromma
Suchada
S
Fun
Hoong-Kun
HK
Williams
Ian D
ID
Sung
Herman H-Y
HH
D036603:Ageratina / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C508039:cadinane