Hereditary papulotranslucent acrokeratoderma.
A 79-year-old woman presented with a history of peeling of the palms and soles that began in young adulthood, with exacerbation after exposure to water. Her mother, 2 sisters, and a female maternal cousin have similar symptoms. Physical examination showed scale and hyperlinearity of the palms. Brief exposure to water initiated the development of 1-to 2-mm, translucent, white papules that were distributed diffusely on the palmar surface, with a concentration at the palmar margins and pressure points. Histopathologic examination showed an acanthotic epidermis with a central depression that was filled with compact orthokeratosis. The physical examination and histopathologic findings are consistent with a diagnosis of hereditary papulotranslucent acrokeratoderma.
Rizzo
Carina
C
Department of Dermatology, New York University, USA.
Bragg
Jennifer
J
Soldano
Anthony C
AC
Cohen
David
D
Soter
Nicholas A
NA
D000169:Acrodermatitis / Q000175:diagnosis / Q000235:genetics*; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000175:diagnosis / Q000235:genetics*; D017444:Skin Diseases, Papulosquamous / Q000175:diagnosis / Q000235:genetics*