title: [Hypoglyceminc effect of flavonoids from Prinsepia utilis on alloxan-induced diabetic mice].
abstract: OBJECTIVE
  To evaluate the hypoglycemic effect of flavonoids from Prinsepia utilis Royle in alloxan-induced diabetic mice.
  
  
  METHODS
  The hypoglycemic effects were investigated in alloxan-induced diabetic mice after oral administration of 300 mg/kg of flavonoids from Prinsepia utilis Royle for four weeks. The blood glucose (GLU), total cholesterol (TC), triglyceride (TG), very low density lipoprotein cholesterol (VLDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN) and body weight of mice were determined.
  
  
  RESULTS
  Flavonoids from Prinsepia utilis Royle had influence on body weight increasing of diabetic mice in three weeks, but had no influence in the fourth week. Flavonoids from Prinsepia utilis Royle exhibited hypoglycemic effects. Among these fractions, flavonoids from Prinsepia utilis Royle significantly reduced GLU, TG and AST level in diabetic mice compared with model control group (P<0.01), markedly reduced VLDL-C, ALT and BUN level in diabetic mice compared with model control group (P<0.05), but had little influence on TC.
  
  
  CONCLUSIONS
  Flavonoids from Prinsepia utilis Royle possess significant hypoglycemic activities, they can improve hypothepatia of diabetic mice and have protective effect on renal function of diabetic mice.
authors.affiliation: College of veterinary medicine, Sichuan Agricultural University, Yaan 525014, China. cqrc_jry@163.com
authors.forename: Ren-Yong
authors.initials: RY
authors.lastname: Jia
authors.forename: Zhong-Qiong
authors.initials: ZQ
authors.lastname: Yin
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Wu
authors.forename: Ding-Bang
authors.initials: DB
authors.lastname: Liu
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Du
authors.forename: Li-Yuan
authors.initials: LY
authors.lastname: Luo
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Xiong
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000496:Alloxan; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D027824:Rosaceae / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D007004:Hypoglycemic Agents; D014280:Triglycerides; D000496:Alloxan; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase