title: Performance evaluation of the Sysmex XS-1000i automated haematology analyser.
abstract: The Sysmex XS-1000i is a compact new, fully automated haematology analyser, designed to generate complete blood counts with five-part leucocyte differential. In our study, a Sysmex XS-1000i instrument was evaluated according to Clinical Laboratory Standards Institute (CLSI) and International Council for Standardization in Haematology (ICSH) guidelines. Precision, carry-over and linearity were determined. Using a total of 700 patient samples, results from the Sysmex XS-1000i were compared with those from a Sysmex XE-2100, an Abbott Cell Dyn 4000 and the manual reference leucocyte differential. Using quality control material, total and within-run imprecision was less than 3% except for platelets. The system demonstrated good linearity over the entire reporting range and no carry-over (<0.5%). The Sysmex XS-1000i showed good correlation with XE-2100, CD-4000 and the manual reference leucocyte differential. Overall flagging sensitivity and specificity were 91% and 48%, respectively. In conclusion, the Sysmex XS-1000i demonstrated good analytical performance, is able to generate a complete blood count with five-part differential on low blood volumes and has considerable back-up capacity.
authors.affiliation: Clinical Laboratory Middelheim, AZ Middelheim, Lindendreef 1, 2020 Antwerp, Belgium. tsghys@hotmail.com
authors.forename: T
authors.initials: T
authors.lastname: Ghys
authors.forename: R
authors.initials: R
authors.lastname: Malfait
authors.forename: J
authors.initials: J
authors.lastname: VAN den Bossche
mesh_terms: D001772:Blood Cell Count / Q000295:instrumentation*; D006405:Hematology / Q000295:instrumentation*; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity