title: [Study on antitumor activity of extract from roots of Gossampinus malabaria].
abstract: OBJECTIVE
  To study the antitumor activity of extract (Y2) from the roots of Gossampinus malabaria (L.) Merr.
  
  
  METHODS
  Based on the inhibitory effects of Y2 on FGC-85 in vitro, life-prolonging effects of Y2 on mice transplanted with ascites sarcoma-180 (S-180) and antitumor activity of Y2 on mice transplanted with U14 were investigated in vivo.
  
  
  RESULTS
  The growth of S-180 in mice was significantly inhibited by Y2. The inhibitory growth effect was dosage-dependent. Y2 could significantly prolong the survival time of mice transplanted with S-180. The inhibition rate of Y2 on the growth of U14 in mice was higher than 90% under high, medium and low dosage.
  
  
  CONCLUSIONS
  Y2 has distinct antitumor activity.
authors.affiliation: Fujian Provincial Institute of Medical Sciences, Fuzhou 350001, China.
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Qi
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.forename: Shun-Min
authors.initials: SM
authors.lastname: Guo
authors.forename: Hui-Qing
authors.initials: HQ
authors.lastname: Jue
authors.forename: Sui
authors.initials: S
authors.lastname: Lin
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D035161:Bombacaceae; D035163:Bombax / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000473:pathology; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D003520:Cyclophosphamide