title: Distinct reactivity of Pd(OTs)2: the intermolecular Pd(II)-catalyzed 1,2-carboamination of dienes.
abstract: A Pd-catalyzed intermolecular 1,2-carboamination route to indolines from N-aryl ureas and 1,3-dienes that proceeds under mild conditions in relatively nonacidic media, is presented. The in situ generation, or preformation, of a palladium tosylate emerges as a key parameter in gaining the requisite reactivity for the C-H insertion/carbopalladation/nucleophilic displacement process.
authors.affiliation: School of Chemistry, Cantock's Close, University of Bristol, Bristol, BS8 1TS, UK.
authors.forename: Chris E
authors.initials: CE
authors.lastname: Houlden
authors.forename: Chris D
authors.initials: CD
authors.lastname: Bailey
authors.forename: J Gair
authors.initials: JG
authors.lastname: Ford
authors.forename: Michel R
authors.initials: MR
authors.lastname: Gagné
authors.forename: Guy C
authors.initials: GC
authors.lastname: Lloyd-Jones
authors.forename: Kevin I
authors.initials: KI
authors.lastname: Booker-Milburn
mesh_terms: D000586:Amination; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry*; D011090:Polyenes / Q000737:chemistry*; D013449:Sulfonamides; D014050:Toluene / Q000031:analogs & derivatives; D014508:Urea; D000096926:Benzenesulfonamides
chemical_list: D007211:Indoles; D010165:Palladium; D011090:Polyenes; D013449:Sulfonamides; D014050:Toluene; D014508:Urea; C013307:2-toluenesulfonamide; D000096926:Benzenesulfonamides