title: Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns.
abstract: OBJECTIVE
  To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS).
  
  
  METHODS
  A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed.
  
  
  RESULTS
  In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses.
  
  
  CONCLUSIONS
  CD14 and TLR4 showed an association with AS in the Finns only.
authors.affiliation: NIHR OxfordMusculoskeletal Biomedical Research Unit and BotnarResearch Centre, Oxford, UK. jennyp@well.ox.ac.uk
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Pointon
authors.forename: Kay
authors.initials: K
authors.lastname: Chapman
authors.forename: David
authors.initials: D
authors.lastname: Harvey
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Sims
authors.forename: Linda
authors.initials: L
authors.lastname: Bradbury
authors.forename: Kari
authors.initials: K
authors.lastname: Laiho
authors.forename: Markku
authors.initials: M
authors.lastname: Kauppi
authors.forename: Kalevi
authors.initials: K
authors.lastname: Kaarela
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Brown
authors.forename: B Paul
authors.initials: BP
authors.lastname: Wordsworth
mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005387:Finland; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013167:Spondylitis, Ankylosing / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D006113:United Kingdom
chemical_list: D018950:Lipopolysaccharide Receptors; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4