title: Has the 2004 revision of the International Society of Heart and Lung Transplantation grading system improved the reproducibility of the diagnosis and grading of cardiac transplant rejection?
abstract: We compared the interobserver reproducibility of the 1990 and 2004 International Society for Heart and Lung Transplantation (ISHLT) grading system for cardiac rejection. The 2004 ISHLT grading system for cardiac allograft rejection did not improve reproducibility partly due to pathologists' disagreement in diagnosing Grades 1B/1R and 3A/2R rejection. To achieve better reproducibility, better criteria for defining 1B/1R vs. 3A/2R rejection and markers of myocyte injury are needed.
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Yang
authors.forename: Chi K
authors.initials: CK
authors.lastname: Lai
authors.forename: David W
authors.initials: DW
authors.lastname: Gjertson
authors.forename: Tamar
authors.initials: T
authors.lastname: Baruch-Oren
authors.forename: Seong H
authors.initials: SH
authors.lastname: Ra
authors.forename: William
authors.initials: W
authors.lastname: Watts
authors.forename: William D
authors.initials: WD
authors.lastname: Wallace
authors.forename: Peter
authors.initials: P
authors.lastname: Shintaku
authors.forename: Jon A
authors.initials: JA
authors.lastname: Kobashigawa
authors.forename: Michael C
authors.initials: MC
authors.lastname: Fishbein
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D006084:Graft Rejection / Q000145:classification / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D016027:Heart Transplantation / Q000009:adverse effects*; D016041:Heart-Lung Transplantation / Q000009:adverse effects*; D006801:Humans; D007150:Immunohistochemistry; D009206:Myocardium / Q000737:chemistry / Q000473:pathology*; D015588:Observer Variation; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D012955:Societies, Medical / Q000592:standards*
chemical_list: D015415:Biomarkers