title: Two novel bibenzyls from Dendrobium trigonopus.
abstract: Two novel bibenzyl trigonopols A (1) and B (2), together with seven known compounds, gigantol (3), tristin (4), moscatin (5), hircinol (6), naringenin (7), 3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-ol (8), and ( - )-syringaresinol (9), have been isolated from the stems of Dendrobium trigonopus, of which compounds 6, 8, and 9 were isolated for the first time from this species. The structures of two new compounds were elucidated as threo-22-(17-hydroxyl-9-(3-hydroxyl-4-methoxy-phenethyl)-13,16,18-trimethoxy-21H-benzo[c]chromen-21-yl)ethane-22, 23-diol (1) and 9-(4-hydroxyl-3-methoxy-phenethyl)-17-(21-hydroxyl-20-methoxy-phenyl)chroman-11, 16-diol (2) on the basis of spectroscopic methods. Trigonopol A was found to exhibit antiplatelet aggregation activity in vitro with 67.55% inhibitory ration at 1.4337 x 10(- 3) M.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resource in West China, Kunming Institute of Botany, the Chinese Academy of Science, Kunming, China.
authors.forename: Jiang-Miao
authors.initials: JM
authors.lastname: Hu
authors.forename: Ji-Jun
authors.initials: JJ
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001632:Bibenzyls / Q000737:chemistry* / Q000494:pharmacology; D031667:Dendrobium / Q000737:chemistry*; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology; D011817:Rabbits
chemical_list: D001632:Bibenzyls; D010975:Platelet Aggregation Inhibitors; C532696:trigonopol A; C532697:trigonopol B