The CCR5 (-2135C/T) polymorphism may be associated with the development of Kawasaki disease in Korean children.
BACKGROUND
Kawasaki disease (KD) is an acute vasculitis syndrome of unknown etiology that frequently affects small to medium size arteries. C-C chemokine receptor 5 (CCR5) is a chemokine receptor that binds C-C chemokines. This study investigated the association of the CCR5 (-2135C/T) polymorphism with KD in Korean children.


METHODS
The study population consisted 189 Korean children with KD and 194 Korean children with congenital heart disease (CHD). CCR5 (-2135C/T) polymorphism genotypes were determined using the single-base extension method.


RESULTS
The allele frequencies of the CCR5 (-2135C/T) polymorphism differed significantly between CHD children and KD children (-2135T/T, 16.75% vs. 30.05%, aOR 2.14, 95% CI 1.31-3.51). The tested laboratory parameters differed significantly between the KD and CHD groups. The development of coronary artery aneurysm in KD patients was not associated with the CCR5 polymorphism.


CONCLUSIONS
Our findings suggest that the T allele at the CCR5 (-2135C/T) polymorphism might be associated with the development of KD in Korean children but does not appear to be associated with the development of coronary artery aneurysm.
Jhang
Won Kyoung
WK
Department of Pediatrics, Asan Medical Center, College of Medicine, Ulsan University, Seoul, South Korea.
Kang
Mi-Jin
MJ
Jin
Hyun-Seung
HS
Yu
Jinho
J
Kim
Byoung-ju
BJ
Kim
Bong Seong
BS
Lee
Jong-Keuk
JK
Seo
Eul-Ju
EJ
Yoo
Han-Wook
HW
Park
In Sook
IS
Hong
Young Mi
YM
Hong
Soo-Jong
SJ
D000483:Alleles; D002648:Child; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D007723:Korea / Q000453:epidemiology; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D019713:Receptors, CCR5 / Q000235:genetics*
D019713:Receptors, CCR5