When less is more: apoptosis during acute kidney injury.
The paper by Ma and Devarajan suggests that the subtle apoptotic events that occur in the distal nephron after acute kidney injury might have a greater than expected impact on the adjacent proximal tubules and kidney function. Understanding these events might facilitate development of therapeutic means to ameliorate acute kidney injury.
Arany
Istvan
I
Department of Pediatrics, Division of Pediatric Nephrology, University of Mississippi Medical Center, Research Wing, Jackson, Mississippi, USA. iarany@ped.umsmed.edu
D058186:Acute Kidney Injury / Q000209:etiology / Q000473:pathology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007687:Kidney Tubules, Proximal / Q000503:physiopathology; D009399:Nephrons / Q000503:physiopathology; D015427:Reperfusion Injury / Q000473:pathology*