title: A review of adherence to drug therapy in patients with overactive bladder.
abstract: Drug therapy for overactive bladder (OAB) is associated with improvements in symptoms and quality of life, but the short- and long-term adherence and persistence is suboptimal. In this review we outline methods of measuring, and factors affecting, adherence to pharmacotherapy in patients with OAB. Clinical practice suggests that adherence rates reported in clinical trials are much greater than in real practice. Factors affecting adherence include psychological and social variables that might alter patients' perception of the benefits of taking medication, and the effect of comorbidity and polypharmacy. Whilst there is some evidence that lack of efficacy and side-effects are contributory, these additional factors are also important.
authors.affiliation: Guys and St Thomas NHS Foundation Trust, and University College London, London, UK.
authors.forename: Ramandeep K
authors.initials: RK
authors.lastname: Basra
authors.forename: Adrian
authors.initials: A
authors.lastname: Wagg
authors.forename: Christopher
authors.initials: C
authors.lastname: Chapple
authors.forename: Linda
authors.initials: L
authors.lastname: Cardozo
authors.forename: David
authors.initials: D
authors.lastname: Castro-Diaz
authors.forename: Montserrat Espuna
authors.initials: ME
authors.lastname: Pons
authors.forename: Mike
authors.initials: M
authors.lastname: Kirby
authors.forename: Ian
authors.initials: I
authors.lastname: Milsom
authors.forename: Mark
authors.initials: M
authors.lastname: Vierhout
authors.forename: Philip
authors.initials: P
authors.lastname: Van Kerrebroeck
authors.forename: Con
authors.initials: C
authors.lastname: Kelleher
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D010349:Patient Compliance; D011788:Quality of Life; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
chemical_list: D018727:Muscarinic Antagonists