Assessment and management of breakthrough pain in cancer patients: current approaches and emerging research.
Cancer pain is highly prevalent and often severe. Fortunately, most cancer pain can be readily managed, with up to 90% of patients responding well to standard interventions. However, breakthrough cancer pain-brief flares of severe pain superimposed on baseline pain-is common, difficult to manage, and often negatively impacts patients' quality of life. Breakthrough cancer pain is traditionally managed with oral, immediate-release opioids. However, because of its sudden onset and severity, oral opioids often fall short of providing adequate control. Research into novel approaches to pain management has identified several innovative strategies for this difficult cancer pain problem. We describe current approaches to assess, define, characterize, and treat breakthrough cancer pain, and summarize recent clinical research on novel agents, novel routes of drug delivery, and other advances in its management.
Hagen
Neil A
NA
Tom Baker Cancer Centre, Alberta Cancer Board; Division of Palliative Medicine, University of Calgary, 1331 29th Street NW, Calgary, Alberta T2N 4N2, Canada. neilha@cancerboard.ab.ca
Biondo
Patricia
P
Stiles
Carla
C
D000701:Analgesics, Opioid / Q000008:administration & dosage; D019468:Disease Management; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy*; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D010148:Intractable Pain / Q000150:complications / Q000473:pathology / Q000628:therapy*; D012106:Research / Q000639:trends*; D012107:Research Design
D000701:Analgesics, Opioid