title: Morphine-induced acute lung injury.
abstract: A 38-year-old woman who had familial adenomatous polyposis was admitted to the intensive care unit with an episode of severe sepsis 5 days after undergoing a pancreas-preserving duodenectomy. Laparotomy with removal of an intra-abdominal abscess, followed by closed postoperative continuous lavage for 10 days, was performed. During two courses of planned tracheal extubation, the patient developed an acute lung injury, making a reintubation necessary. In both events, the patient received small doses of continuous morphine before the extubation. Morphine may induce the development of an acute lung injury in patients, whereas the exact pathophysiologic and pharmacologic mechanisms remain unclear.
authors.affiliation: Department of Anaesthesiology, University of Heidelberg, D-69120 Heidelberg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Hainer
authors.forename: Moritz N
authors.initials: MN
authors.lastname: Wente
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Hallscheidt
authors.forename: Jan
authors.initials: J
authors.lastname: Schmidt
authors.forename: Eike
authors.initials: E
authors.lastname: Martin
authors.forename: Markus W
authors.initials: MW
authors.lastname: Büchler
authors.forename: Markus A
authors.initials: MA
authors.lastname: Weigand
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology; D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects*; D004386:Duodenum / Q000601:surgery; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D009020:Morphine / Q000009:adverse effects*; D011859:Radiography; D018805:Sepsis / Q000382:microbiology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine