title: Acute necrotising pulmonary vasculitis and pulmonary hypertension in a juvenile dog.
abstract: A five-month-old female Jack Russell terrier was presented for investigation of acute lethargy, anorexia, coughing, respiratory distress and weakness. Examination findings included cyanosis, a grade 3 of 6 systolic heart murmur and prolonged capillary refill time. Radiography and echocardiography revealed severe pulmonary hypertension, cor pulmonale and right-sided heart failure. Indirect measurement of the systolic pulmonary artery pressure estimated pressures over 100 mmHg. Despite treatment the patient died. Post-mortem examination did not identify a congenital cardiovascular anomaly. Histopathology confirmed acute necrotising pulmonary arteritis and immunohistochemistry failed to identify any immune complex or complement deposition.
authors.affiliation: School of Veterinary & Biomedical Sciences, Division of Health Sciences, School of Veterinary Clinical Science, Murdoch University, South Street, Murdoch, Western Australia 6150, Australia.
authors.forename: N J
authors.initials: NJ
authors.lastname: Russell
authors.forename: P J
authors.initials: PJ
authors.lastname: Irwin
authors.forename: B J
authors.initials: BJ
authors.lastname: Hopper
authors.forename: T
authors.initials: T
authors.lastname: Olivry
authors.forename: P K
authors.initials: PK
authors.lastname: Nicholls
mesh_terms: D000208:Acute Disease; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006976:Hypertension, Pulmonary / Q000662:veterinary*; D009336:Necrosis / Q000662:veterinary*; D014657:Vasculitis / Q000662:veterinary*; D014700:Verapamil / Q000627:therapeutic use
chemical_list: D014151:Anti-Anxiety Agents; D005665:Furosemide; D014700:Verapamil