title: Assessment of the suitability of a new composite as a bone defect filler in a rabbit model.
abstract: To assess the suitability of clinical application of a new composite consisting of calcium phosphate cement (CPC), chitosan fibre and gelatin, a bilateral supracondyle hole defect (5 mm in diameter) was developed in the femurs of 40 New Zealand white rabbits and filled with either the composite or CPC. Macroscopic, radiological, histological and histomorphometric evaluations were performed at the time points of 1, 3, 6 and 12 months post-operation. New bone formation of the composite group was 46.5 +/- 3.2% within 12 months, while that of the CPC group was 12.4 +/- 2.7% (p < 0.05). No adverse response was found in either group. In addition, it was very interesting that the new bone grew into the implant only in the composite group. By histochemical staining we found that chitosan fibre was surrounded by monocytes and macrophages after 3 months. Overall, our study demonstrated that both CPC and the composite had osteoconductive characteristics and good biocompatibility, but the composite presented superior bioresorbability and a higher rate of new bone formation.
authors.affiliation: Orthopaedics Institute of Chinese PLA, 89th Hospital, Weifang, Shandong 261021, People's Republic of China. panzhaohui89yy@yahoo.com
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Pan
authors.forename: Pingping
authors.initials: P
authors.lastname: Jiang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects / Q000737:chemistry; D001843:Bone Cements / Q000009:adverse effects / Q000737:chemistry* / Q000627:therapeutic use*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002130:Calcium Phosphates / Q000009:adverse effects / Q000737:chemistry*; D023421:Models, Animal; D011817:Rabbits; D011859:Radiography
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates