Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus.
The retrospective study of 34 patients with Hodgkin lymphoma-associated hemophagocytic syndrome led us to define this association as a specific disorder. Its characteristics are male predominance (male-to-female sex ratio, 3.3:1), immunodeficiency-like histological features (lymphocyte depletion, 45% of cases; mixed cellularity Hodgkin lymphoma subtype, 40%), and strong association with Epstein-Barr virus (94%).
Ménard
Fanny
F
Université Paris-Sud, F-94270, Paris, France.
Besson
Caroline
C
Rincé
Patricia
P
Lambotte
Olivier
O
Lazure
Thierry
T
Canioni
Danielle
D
Hermine
Olivier
O
Brousset
Pierre
P
Martin
Antoine
A
Gaulard
Philippe
P
Raphaël
Martine
M
Larroche
Claire
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000150:complications* / Q000821:virology*; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged