title: Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole.
abstract: A class of Ag(I) N-heterocyclic carbene silver complexes, 1-3, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes 1-3 are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows 1 to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo.
authors.affiliation: Knight Chemical Laboratory 105, Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Doug A
authors.initials: DA
authors.lastname: Medvetz
authors.forename: Khadijah M
authors.initials: KM
authors.lastname: Hindi
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Panzner
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Ditto
authors.forename: Yang H
authors.initials: YH
authors.lastname: Yun
authors.forename: Wiley J
authors.initials: WJ
authors.lastname: Youngs