title: The incidences of resistance to cephalosporins and fluorinated 4-quinolones in similar strains isolated in Glasgow and Edinburgh.
abstract: Bacterial sensitivity to cefuroxime, ceftazidime, cefotaxime, ciprofloxacin and ofloxacin was determined for 1386 urinary and bacteraemia isolates from Glasgow and Edinburgh to detemine the impact of these antibacterials on the development of resistance. The MIC(50) and MIC(90) values were determined for each species or genus. Cefuroxine was the least effective antibacterial drug and cefotaxime was the most potent cephalosporin, but it rarely matched the efficacy of the 4-quinolones. There was little difference in the sensitivities of Gram-negative bacteria from Edinburgh of Glasgow but Gram-positive bacteria isolated in Glasgow were usually more resistant. There has been no significant emergence of resistant Gram-negative bacteria even amongst the Pseudomonas spp.; however, the proportion of Gram-positive bacteria resistant to these drugs is higher in Scotland than elsewhere.
authors.affiliation: Department of Medical Microbiology, Scottish Antibiotic Reference Laboratory, The Medical School, University of Edinburgh, Edinburgh, UK.
authors.forename: R H
authors.initials: RH
authors.lastname: Paton
authors.forename: C J
authors.initials: CJ
authors.lastname: Thomson
authors.forename: J
authors.initials: J
authors.lastname: Hood
authors.forename: S
authors.initials: S
authors.lastname: Dallas
authors.forename: R S
authors.initials: RS
authors.lastname: Miles
authors.forename: S G
authors.initials: SG
authors.lastname: Amyes