title: Efficacy of prophylactic extended lymphadenectomy with gastrectomy for patients with node-negative advanced gastric carcinoma.
abstract: OBJECTIVE
  Extended lymphadenectomy with gastrectomy is widely performed for patients with advanced gastric carcinoma. However, the therapeutic value of prophylactic extensive lymphadenectomy in patients with node-negative advanced gastric cancer is controversial.
  
  
  METHODS
  We retrospectively analyzed 221 patients who underwent curative gastrectomy for advanced gastric carcinoma without lymph node metastasis to evaluate the effect of prophylactic extended lymphadenectomy on postoperative survival. The postoperative survival rate of patients who underwent extended lymphadenectomy was compared with that of patients who underwent limited lymphadenectomy. Predictive risk factors for tumor recurrence and recurrent patterns also were analyzed.
  
  
  RESULTS
  Extended lymphadenectomy improved the postoperative survival rate of patients with advanced tumors even when lymph node spread was absent. Whether or not prophylactic extended lymphadenectomy was performed significantly affected tumor recurrence in patients with node-negative advanced gastric carcinoma.
  
  
  CONCLUSIONS
  Extensive lymphadenectomy with gastrectomy prolongs survival of patients with node-negative advanced tumors.
authors.affiliation: Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan. otsuji@koto.kpu-m.ac.jp
authors.forename: Eigo
authors.initials: E
authors.lastname: Otsuji
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kuriu
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ichikawa
authors.forename: Toshiya
authors.initials: T
authors.lastname: Ochiai
authors.forename: Kazuma
authors.initials: K
authors.lastname: Okamoto
authors.forename: Akeo
authors.initials: A
authors.lastname: Hagiwara
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Yamagishi
mesh_terms: D005260:Female; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*