title: Anthraquinones from the roots of Prismatomeris malayana.
abstract: A novel anthraquinone, 1,3-dihydroxy-5,6-dimethoxy-2-methoxymethyl-9,10-anthraquinone (9) and a new natural product, 2-hydroxymethyl-1-methoxy-9,10-anthraquinone (8) were isolated from the roots of Prismatomeris malayana together with seven known anthraquinones, tectoquinone (1), 1-hydroxy-2-methyl-9,10-anthraquinone (2), rubiadin (3), rubiadin-1-methyl ether (4), 1,3-dihydroxy-5,6-dimethoxy-2-methyl-9,10-anthraquinone (5), nordamnacanthal (6), and damnacanthal (7). Their structures were determined on the basis of spectroscopic data. Some of the anthraquinones were tested for anticancer, antifungal, and antimalarial activities.
authors.affiliation: Faculty of Science, Department of Chemistry, Silpakorn University, Nakorn Pathom 73000, Thailand. pittayat@su.ac.th
authors.forename: Pittaya
authors.initials: P
authors.lastname: Tuntiwachwuttikul
authors.forename: Yuttapon
authors.initials: Y
authors.lastname: Butsuri
authors.forename: Piyanut
authors.initials: P
authors.lastname: Sukkoet
authors.forename: Uma
authors.initials: U
authors.lastname: Prawat
authors.forename: Walter Charles
authors.initials: WC
authors.lastname: Taylor
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D019666:Rubiaceae / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: C534270:1,3-dihydroxy-5,6-dimethoxy-2-methoxymethyl-9,10-anthraquinone; C534271:2-hydroxymethyl-1-methoxy-9,10-anthraquinone; D000447:Aldehydes; D000880:Anthraquinones; D000935:Antifungal Agents; D000962:Antimalarials; D000970:Antineoplastic Agents; C465644:nordamnacanthal; C042834:9,10-anthraquinone; C079170:damnacanthal; C079172:rubiadin 1-methyl ether; C072500:rubiadin