title: Improved biocompatibility and pharmacokinetics of silica nanoparticles by means of a lipid coating: a multimodality investigation.
abstract: Silica is a promising carrier material for nanoparticle-facilitated drug delivery, gene therapy, and molecular imaging. Understanding of their pharmacokinetics is important to resolve bioapplicability issues. Here we report an extensive study on bare and lipid-coated silica nanoparticles in mice. Results obtained by use of a wide variety of techniques (fluorescence imaging, inductively coupled plasma mass spectrometry, magnetic resonance imaging, confocal laser scanning microscopy, and transmission electron microscopy) showed that the lipid coating, which enables straightforward functionalization and introduction of multiple properties, increases bioapplicability and improves pharmacokinetics.
authors.affiliation: Condensed Matter and Interfaces, University Utrecht, P.O. Box 80000, 3508 TA Utrecht, The Netherlands.
authors.forename: Matti M
authors.initials: MM
authors.lastname: van Schooneveld
authors.forename: Esad
authors.initials: E
authors.lastname: Vucic
authors.forename: Rolf
authors.initials: R
authors.lastname: Koole
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Joanne
authors.initials: J
authors.lastname: Stocks
authors.forename: David P
authors.initials: DP
authors.lastname: Cormode
authors.forename: Cheuk Y
authors.initials: CY
authors.lastname: Tang
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Gordon
authors.forename: Klaas
authors.initials: K
authors.lastname: Nicolay
authors.forename: Andries
authors.initials: A
authors.lastname: Meijerink
authors.forename: Zahi A
authors.initials: ZA
authors.lastname: Fayad
authors.forename: Willem J M
authors.initials: WJ
authors.lastname: Mulder
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics*; D008055:Lipids / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D051379:Mice; D008810:Mice, Inbred C57BL; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics*
chemical_list: D001672:Biocompatible Materials; D008055:Lipids; D012822:Silicon Dioxide