title: Longitudinal study of new eye lesions in children with toxoplasmosis who were not treated during the first year of life.
abstract: OBJECTIVE
  To determine the incidence of new chorioretinal lesions in children with toxoplasmosis diagnosed after, and therefore not treated during, their first year.
  
  
  METHODS
  Prospective longitudinal cohort study.
  
  
  METHODS
  Thirty-eight children were evaluated in Chicago between 1981 and 2005 for new chorioretinal lesions. Thirty-eight children and mothers had serum IgG antibody to Toxoplasma gondii.
  
  
  RESULTS
  Twenty-eight of 38 children had one of the following: diagnosis with serum antibody to T. gondii indicative of chronic infection at age 24 months, central nervous system calcifications, hydrocephalus, illness compatible with congenital toxoplasmosis perinatally but not diagnosed at that time. Twenty-five returned for follow-up during 1981 to 2005. Their mean (range) age at last exam was 10.9 +/- 5.7 (range, 3.5 to 27.2) years and mean follow-up was 5.7 +/- 2.9 years. Eighteen (72%) children developed at least one new lesion. Thirteen (52%) had new central lesions, 11 (44%) had new peripheral lesions, and six (24%) had both. Thirteen (52%) had new lesions diagnosed at age > or =10 years. New lesions were found at more than one visit in four (22%), and bilateral new lesions developed in seven (39%) of 18 children who developed new lesions. Of 10 additional children with eye findings and serologic tests indicative of chronic infection, six returned for follow-up, four (67%) developing new lesions at > or =10 years of age.
  
  
  CONCLUSIONS
  More than 70% developed new chorioretinal lesions. New lesions were commonly diagnosed after the first decade of life.
authors.affiliation: University of Chicago School of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Phan
authors.forename: Kristen
authors.initials: K
authors.lastname: Kasza
authors.forename: Jessica
authors.initials: J
authors.lastname: Jalbrzikowski
authors.forename: A Gwendolyn
authors.initials: AG
authors.lastname: Noble
authors.forename: Paul
authors.initials: P
authors.lastname: Latkany
authors.forename: Annie
authors.initials: A
authors.lastname: Kuo
authors.forename: William
authors.initials: W
authors.lastname: Mieler
authors.forename: Sanford
authors.initials: S
authors.lastname: Meyers
authors.forename: Peter
authors.initials: P
authors.lastname: Rabiah
authors.forename: Kenneth
authors.initials: K
authors.lastname: Boyer
authors.forename: Charles
authors.initials: C
authors.lastname: Swisher
authors.forename: Marilyn
authors.initials: M
authors.lastname: Mets
authors.forename: Nancy
authors.initials: N
authors.lastname: Roizen
authors.forename: Simone
authors.initials: S
authors.lastname: Cezar
authors.forename: Mari
authors.initials: M
authors.lastname: Sautter
authors.forename: Jack
authors.initials: J
authors.lastname: Remington
authors.forename: Paul
authors.initials: P
authors.lastname: Meier
authors.forename: Rima
authors.initials: R
authors.lastname: McLeod
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002825:Chorioretinitis / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies; D014122:Toxoplasma / Q000276:immunology; D014126:Toxoplasmosis, Ocular / Q000151:congenital / Q000175:diagnosis* / Q000628:therapy
chemical_list: D000913:Antibodies, Protozoan; D007074:Immunoglobulin G