title: Persistent pulmonary infection with an azole-resistant Coccidioides species.
abstract: We report a case of a life-threatening, recurrent, and azole-resistant pulmonary coccidioidomycosis in a patient receiving long-term fluconazole therapy for a history of coccidioidal meningitis. Since this diagnosis, the patient has received weekly amphotericin B for more than four years and remains in remission with a stable serum Coccidioides complement fixation antibody titer.
authors.affiliation: Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA. john.kriesel@hsc.utah.edu
authors.forename: John D
authors.initials: JD
authors.lastname: Kriesel
authors.forename: Deanna A
authors.initials: DA
authors.lastname: Sutton
authors.forename: Susan
authors.initials: S
authors.lastname: Schulman
authors.forename: Annette W
authors.initials: AW
authors.lastname: Fothergill
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rinaldi
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001393:Azoles / Q000627:therapeutic use*; D003045:Coccidioides / Q000187:drug effects / Q000302:isolation & purification*; D003047:Coccidioidomycosis / Q000188:drug therapy / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D016921:Meningitis, Fungal / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D012008:Recurrence
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D000666:Amphotericin B