Factor VII -323 decanucleotide D/I polymorphism in atrial fibrillation: implications for the prothrombotic state and stroke risk.
There are limited data on the influence of genetic polymorphisms in atrial fibrillation (AF) stroke risk. We hypothesized that a functional haemostatic polymorphism, that is, the factor VII -323 Del/Ins polymorphism, would influence the prothrombotic state associated with AF, as well as stroke risk. Other functional polymorphisms were also tested.


METHODS
We performed a cross-sectional study of 119 AF patients, who were compared to 96 patients with stroke secondary to AF. In the first patient group, we analysed plasma prothrombin fragment 1+2 levels (F1+2, an index of thrombin generation) to reflect the prothrombotic state of AF.


RESULTS
AF patients carrying the -323 Ins allele had lower plasma F1+2 levels (P=0.015). After multivariate analysis adjusted by age, sex and clinical risk factors, advanced age and 807C/T polymorphism of glycoprotein Ia (GPIa) gene were associated with higher risk of ischaemic stroke (OR: 1.06; P=0.003 and OR: 1.91; P=0.025), whilst FVII Ins -323 allele was associated with lower stroke risk (OR: 0.41; P=0.017).


CONCLUSIONS
FVII -323 Ins allele may modulate the prothrombotic state associated with AF. Despite the small sample size, we found that FVII Ins -323 allele could be associated with a lower stroke risk in AF, whereas the 807C/T polymorphism may increase the risk.
Roldán
Vanessa
V
Centro de Hemodonacíon, Universidad de Murcia, Murcia, Spain.
Marín
Francisco
F
González-Conejero
Rocío
R
García-Honrubia
Antonio
A
Martí
Silvia
S
Alfaro
Aranzazu
A
Valdés
Mariano
M
Corral
Javier
J
Lip
Gregory Y H
GY
Vicente
Vicente
V
D001281:Atrial Fibrillation / Q000097:blood / Q000150:complications* / Q000235:genetics*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005167:Factor VII / Q000235:genetics*; D005260:Female; D006801:Humans; D039421:Integrin alpha2 / Q000235:genetics*; D008297:Male; D010446:Peptide Fragments / Q000097:blood; D011110:Polymorphism, Genetic / Q000235:genetics*; D011498:Protein Precursors / Q000097:blood; D011516:Prothrombin; D020521:Stroke / Q000235:genetics*
D039421:Integrin alpha2; D010446:Peptide Fragments; D011498:Protein Precursors; C029733:prothrombin fragment 1; C044183:prothrombin fragment 2; D005167:Factor VII; D011516:Prothrombin