title: Variation in the purinergic P2RX(7) receptor gene and schizophrenia.
abstract: BACKGROUND
  The purinergic receptor gene P2RX(7) is located in a major linkage hotspot for schizophrenia and bipolar disorders, 12q21-33. It has previously been associated with bipolar disorder but has never been analysed in relation to schizophrenia, although it is involved in several neuronal processes associated with schizophrenia.
  
  
  METHODS
  Nine functionally characterised variants in P2RX(7) were genotyped in 389 patients diagnosed with schizophrenia, each matched on sex, birth-year and month with two healthy controls.
  
  
  RESULTS
  We did not find association between P2RX(7) and schizophrenia and stratification on gender did not change this result. The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding.
  
  
  CONCLUSIONS
  P2XR(7) was not associated with schizophrenia in this study.
authors.affiliation: Research Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen University Hospital, DK-4000 Roskilde, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hansen
authors.forename: Klaus D
authors.initials: KD
authors.lastname: Jakobsen
authors.forename: Mogens
authors.initials: M
authors.lastname: Fenger
authors.forename: Jimmi
authors.initials: J
authors.lastname: Nielsen
authors.forename: Karoline
authors.initials: K
authors.lastname: Krane
authors.forename: Anders
authors.initials: A
authors.lastname: Fink-Jensen
authors.forename: Henrik
authors.initials: H
authors.lastname: Lublin
authors.forename: Henrik
authors.initials: H
authors.lastname: Ullum
authors.forename: Sally
authors.initials: S
authors.lastname: Timm
authors.forename: August G
authors.initials: AG
authors.lastname: Wang
authors.forename: Niklas Rye
authors.initials: NR
authors.lastname: Jørgensen
authors.forename: Thomas
authors.initials: T
authors.lastname: Werge
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D003718:Denmark; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D018048:Receptors, Purinergic P2 / Q000235:genetics*; D058486:Receptors, Purinergic P2X7; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: C546468:P2RX7 protein, human; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7