[Effect of norfloxacin on ultrastructure characteristics of the loach embryos].
The ultrastructure of embryo cells of the loach (Misgurnus fossilis L.) at the stage of the first and the tenth blastomer divisions in the control and under the conditions of fluoroquinolone norfloxacin (5 and 25 mkg/ml) influences has been investigated. The effect of this antibiotic has resulted in significant ultrastructural changes of embryo cells, such as hypertrophy of channels of the smooth and rough endoplasmic reticulum, disorganization of mitochondrias and cytoplasm membrane destructions of embryo. It has been established that fluoroquinolone inhibited biosynthetic processes, directly influencing on the blastomer biosynthetic structures. Such results testify a high norfloxacin embryotoxicity.
Tselevych
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003531:Cypriniformes / Q000196:embryology*; D004625:Embryo, Nonmammalian / Q000187:drug effects / Q000648:ultrastructure; D009643:Norfloxacin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D009643:Norfloxacin