[Mechanism of regulation of synthesis and secretion of human chorionic gonadotropin (hCG) during pregnancy].
Human chorionic gonadotropin (hCG) is an essential hormone for development and sustaining of gestation. Adequate hCG production is fundamental for pregnancy success since abnormal hCG serum concentrations have been correlated with pregnancy anomalies such as recurrent abortions and preeclampsia. Regulation of hCG production involves diverse molecules associated with different signaling pathways, which have complicated the establishment of the mechanisms involved in its production. The present study provides a critical review of the most relevant findings related to hCG production and functions during pregnancy, in order to help to understand some related pathologies and to treat them more adequately.
Barrera
David
D
Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F. berrera1912@gmail.com
Chirinos
Mayel
M
García-Becerra
Rocío
R
D006063:Chorionic Gonadotropin / Q000096:biosynthesis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000502:physiology*
D006063:Chorionic Gonadotropin