title: [A case of advanced gastric cancer with multiple liver metastases completely responding to combination of paclitaxel and S-1].
abstract: A 46-year-old female was admitted to Kagoshima University Hospital with a complaint of epigastralgia and dysphasia. Gastrointestinal scopy revealed advanced gastric cancer in the upper third of the stomach. Pathological diagnosis of the biopsy specimen was moderately-differentiated adenocarcinoma. Abdominal CT suggested multiple liver metastases, so a combination of biweekly paclitaxel(PTX)and S-1 was started. After five courses of this regimen, the liver metastases and primary tumor were remarkably regressed. PTX was discontinued because of a grade 3 adverse effect of numbness. Nevertheless S-1 monotherapy for liver metastases resulted in a complete response. She has been well without tumor re-growth for 4 years. The combination of PTX and S-1 may be an effective regimen for gastric cancer with liver metastases.
authors.affiliation: Dept. of Surgical Oncology, Digestive Surgery Kagoshima University School of Medicine.
authors.forename: Sumiya
authors.initials: S
authors.lastname: Ishigami
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hamada
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nakajo
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Uenosono
authors.forename: Takaaki
authors.initials: T
authors.lastname: Arigami
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Setoyama
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Uchikado
authors.forename: Masataka
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Shoji
authors.initials: S
authors.lastname: Natsugoe
authors.forename: Takashi
authors.initials: T
authors.lastname: Aikou
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005773:Gastroscopy; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D008875:Middle Aged; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000627:therapeutic use*; D017239:Paclitaxel / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D005641:Tegafur / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel