Integration of human papilloma virus type 26 in laryngeal cancer of a child.
Squamous cell carcinoma (SCC) in larynx is rare with children and adolescents. Usually larynx cancer is common with male smokers in the 7th decade. Among patients with no history of tobacco and/or alcohol consumption several factors have can play a role in the outbreak of laryngeal cancer: such as individual predisposition, radiation, gastroesophageal reflux, viral infection, dietary factors and environmental influences. In literature only few cases of laryngeal cancer with children are reported. Recent studies show that the most frequent laryngeal malignancy is the embryonal rhabdomyosarcoma. Besides the recurrent respiratory papillomatosis (RRP) based on an infection with human papilloma virus (HPV) types 6 and 11 (low risk) and types 16 and 18 (high risk) is known for a possible malignant transformation towards a SCC. HPV type 26 is only reported as low risk type HPV associated with cervical cancer. Final diagnosis often takes a long time. Initial symptoms such as hoarseness, cough or shortness of breath are often referred to more typical pediatric diseases or laryngeal development.
Muenscher
A
A
University Medical Center Hamburg-Eppendorf, Department of Oto-Rhino-Laryngology, Germany. amuenscher@uke.uni-hamburg.de
Feucht
H H
HH
Kutta
H
H
Tesche
S
S
Wenzel
S
S
D000293:Adolescent; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D015344:DNA Probes, HPV / Q000235:genetics*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000821:virology*; D008297:Male; D037981:Neck Dissection; D009367:Neoplasm Staging; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology*; D016133:Polymerase Chain Reaction; D014827:Vocal Cords / Q000473:pathology / Q000601:surgery
D015344:DNA Probes, HPV