title: [Pathological complete response in an elderly patient with locally advanced gastric cancer treated with S-1/CDDP].
abstract: We report a patient with locally advanced gastric carcinoma successfully treated with S-1/CDDP. The patient was a 77-year-old woman who had gastric cancer surgically diagnosed as T4N2, invading the pancreas and mesocolon. After the firsts exploratory laparotomy, chemotherapy was begun as follows. S-1(80 mg/day)was orally administered for 3 weeks followed by 2 weeks' rest as a course, and CDDP(75 mg/body)was administered by intravenous drip on day 8. Because of severe anorexia and nausea, however, the CDDP administration had to be discontinued. Therefore, we changed the procedure to S-1 single treatments, 2 weeks' administration followed by 2 weeks' rest. The total 9 courses of this procedure proved successful. Subsequently, she underwent curative surgery consisting of total gastrectomy with D2 lymph node dissection, combined with distal pancreatectomy and splenectomy, and obtained pathological CR. S-1/CDDP appears to be an effective treatment modality for advanced gastric cancer.
authors.affiliation: Dept. of Gastroenterological Surgery, National Cancer Center Hospital East.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Nakajima
authors.forename: Kei
authors.initials: K
authors.lastname: Itoh
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Tanishima
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Minami
authors.forename: Tamaki
authors.initials: T
authors.lastname: Noie
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Murata
authors.forename: Toshiro
authors.initials: T
authors.lastname: Konishi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood; D002945:Cisplatin / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005743:Gastrectomy; D005773:Gastroscopy; D006801:Humans; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin