Evaluation of the binding effect of human serum albumin on the properties of granules.
The main objective of this study was the application of a solution of human serum albumin as a granulating fluid. The properties of the granules formed were evaluated and compared with those when a conventional binder was applied in the same concentration. The powder mixture contained a soluble (mannitol) and an insoluble component (different types of cellulose). The protein solution applied exerted an appropriate aggregating effect if the system contained microcrystalline celluloses. Powdered cellulose was not suitable for the granulation with human serum albumin solution. As compared with the same concentration of the conventionally applied cellulose ethers as binder, the prepared granules exhibited a larger particle size, a significantly better compressibility, a higher breaking hardness and a favourable deformation process. These findings mainly reflect the good adhesive properties of the protein. The best compressibility and mechanical behaviour were attained on the application of the microcrystalline cellulose Vivapur type 105. This favourable behaviour may be connected with the wettability of cellulose. These results suggest that the formulation of tablets may be easier from an active agent in the serum that binds to albumin (e.g. interferon) since the amount of additives (binder) can be reduced.
Kristó
Katalin
K
Department of Pharmaceutical Technology, University of Szeged, Szeged, Hungary.
Bajdik
János
J
Eros
István
I
Pintye-Hódi
Klára
K
D000268:Adhesiveness; D002482:Cellulose / Q000737:chemistry*; D019245:Compressive Strength; D005079:Excipients / Q000737:chemistry*; D006244:Hardness; D006801:Humans; D008353:Mannitol / Q000737:chemistry*; D010316:Particle Size; D012212:Rheology; D012709:Serum Albumin / Q000737:chemistry*; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
D005079:Excipients; D012709:Serum Albumin; D013607:Tablets; D008353:Mannitol; D002482:Cellulose; C109691:microcrystalline cellulose