Effects of European mistletoe (Viscum album L. subsp. album) extracts on activity rhythms of the Syrian hamsters (Mesocricetus auratus).
Antitumor drugs may have some significant nervous system side-effects such as disrupted sleep, eating and drinking patterns. European Mistletoe has been investigated for many decades for its potential use against cancer. To test the hypothesis that the non-antineoplastic effects of mistletoe might be mediated by the actions on the circadian timing system, we have applied mistletoe extracts and vehicle and have measured locomotor activity, feeding and drinking rhythms under constant darkness. Four groups (vehicle, 20 mg kg(-1) ip injection, 40 mg kg(-1) ip injection and 6 g kg(-1) oral administration) were performed for both heat-treated and freeze-dried extracts. None of the administrations changed the locomotor activity, feeding and drinking rhythms in the groups except for 40 mg kg(-1) freeze-dried injected group. The locomotor activity levels decreased in 40 mg kg(-1) freeze-dried extract injected group. These results suggest that, side-effects of mistletoe on circadian timing system of the Syrian hamster depend on the dose and the preparation method of the extract.
Karakas
Alper
A
Faculty of Arts and Sciences, Department of Biology, Abant Izzet Baysal University, Bolu, Turkey.
Turker
Arzu Ucar
AU
Gunduz
Bulent
B
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D006224:Cricetinae; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D008647:Mesocricetus; D009043:Motor Activity / Q000187:drug effects; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D028182:Viscum album / Q000737:chemistry*
D010936:Plant Extracts