title: Sympathetic activity relates to adenosine A(2A) receptor gene variation in blood-injury phobia.
abstract: Variation in the candidate genes adenosine A(2A) receptor (A(2A)R), catechol-O-methyl-transferase (COMT), and norepinephrine transporter (NET) has been suggested to influence vulnerability to panic disorder. We therefore investigated patients with another anxiety disorder with an even higher heritability, the blood-injury phobia, for association of these variants and used sympathetic measures during venipuncture, which serve as a naturalistic trigger of anxiety and autonomic hyperarousal, as an intermediate phenotype of anxiety. Patients homozygous for the A(2A)R 1976T allele as compared to patients carrying at least one 1976C allele exhibited a significantly increased respiratory rate with a trend towards elevated measures of systolic and diastolic blood pressure and respiratory minute volume. None of the sympathetic measures were influenced by the COMT or NET polymorphisms.This study provides preliminary data suggesting an influence of the A(2A)R 1976C/T polymorphism on sympathetic psychophysiological indicators of anxiety-related arousal in blood-injury phobia and thereby further supports a role of the A(2A)R gene in the pathogenesis of anxiety disorders.
authors.affiliation: Department of Psychiatry, University of Münster, Albert-Schweitzer-Strasse 11, 48149 Münster, Germany. hohoffch@uni-muenster.de
authors.forename: C
authors.initials: C
authors.lastname: Hohoff
authors.forename: K
authors.initials: K
authors.lastname: Domschke
authors.forename: K
authors.initials: K
authors.lastname: Schwarte
authors.forename: G
authors.initials: G
authors.lastname: Spellmeyer
authors.forename: C
authors.initials: C
authors.lastname: Vögele
authors.forename: G
authors.initials: G
authors.lastname: Hetzel
authors.forename: J
authors.initials: J
authors.lastname: Deckert
authors.forename: A L
authors.initials: AL
authors.lastname: Gerlach
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D010698:Phobic Disorders / Q000235:genetics* / Q000503:physiopathology; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D043705:Receptor, Adenosine A2A / Q000235:genetics*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
chemical_list: D043705:Receptor, Adenosine A2A