Comparison of Chinese and Western rifapentines and improvement of bioavailability by prior taking of various meals.
Bioavailability was measured by rifapentine (RPE) serum concentrations and by the urinary ratio between RPE and creatinine, in specimens obtained 4-50 h after 600 mg RPE preceded by food. The bioavailabilities of RPEs manufactured in China and by a Western manufacturer were similar after a standard English breakfast, and serum concentrations were also similar to those obtained in an earlier Italian study following a complex meal. Although absorption of RPE was unsatisfactory after lipid-rich biscuits or shortbread, absorption after egges and toast was excellent and was nearly as good after a fast-food sandwich. The urinary measure of bioavailability at 26 h appeared as efficient as peak serum estimations at 6, 8 and 26 h. Fast-food sandwiches are being taken before RPE in a current clinical trial of Chinese RPE in Hong Kong.
Chan
S L
SL
Hong Kong Department of Health, Chest Services Central Office, Wanchai Polyclinic, Hong Kong, China.
Yew
W W
WW
Porter
J H
JH
McAdam
K P
KP
Allen
B W
BW
Dickinson
J M
JM
Ellard
G A
GA
Mitchison
D A
DA