The polymorphism in insulin receptor substrate-1 gene and birth weight in neonates at term.
BACKGROUND
The mutation of the IRS-1 gene is one of the genetic risk factors which, it is speculated, is associated with insulin resistance or predisposition to type 2 diabetes. The aim of our study was to evaluate the association between the Gly972Arg polymorphism in the IRS-1 gene and birth weight in newborn children with adequate gestational age.


METHODS
100 newborn children with adequate gestational age (38-42 weeks), whose mother had no disorders during pregnancy, were studied. Genomic DNA was extracted from umbilical cord blood leukocytes, and Gly972Arg polymorphism in the IRS-1 gene was genotyped using the PCR-based method.


RESULTS
Birth weight was significantly lower in the newborn with the IRS-1 Gly972Arg polymorphism compared with a control group (3161.75 +/- 380.86 g vs. 3427.92 +/- 468.86 g). Body length and head circumference at birth were also lower in the neonates with that polymorphism (54.38 +/- 3.13 cm vs. 52.69 +/- 2.91 cm, and 34.08 +/- 1.47 vs. 33.63 +/- 0.81, respectively).


CONCLUSIONS
The results suggest that the Gly972Arg genotype is associated with lower birth weight, body length and head circumference in neonates with adequate gestational age.
Simońska-Cichocka
Edyta
E
Department of Internal Medicine, Diabetology and Nephrology, Medical University of Silesia, Zabrze, Poland. esimonska@op.pl
Gumprecht
Janusz
J
Zychma
Marcin
M
Witkowska
Agnieszka
A
Misiołek
Hanna
H
Slawska
Helena
H
Oslislo
Anna
A
Grzeszczak
Władysław
W
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D001724:Birth Weight / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000502:physiology*; D055504:Insulin Receptor Substrate Proteins; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D009154:Mutation; D011110:Polymorphism, Genetic; D011972:Receptor, Insulin / Q000235:genetics*
D048868:Adaptor Proteins, Signal Transducing; C526292:IRS1 protein, human; D055504:Insulin Receptor Substrate Proteins; D011972:Receptor, Insulin