[Study on the release of oleanolic acid loaded nanocapsules in vitro].
OBJECTIVE
To study the release of oleanolic acid loaded nanocapsules in vitro.


METHODS
The rules of drug release in vitro from oleanolic acid loaded nanocapsules were observed by dynamic penetration system and HPLC.


RESULTS
The profile curve of oleanolic acid loaded nanocapsules was fit for the Weibull equation. The release t(1/2) of oleanolic acid loaded nanocapsules was about 6.7 times as that of original oleanolic acid.


CONCLUSIONS
Oleanolic acid loaded nanocapsules have obviously sustained effect.
Huang
Yi
Y
Xiangya Hospital, Central South University, Changsha 410008, China. huangyihy2008@163.com
Li
Yuan
Y
Li
Xin-Zhong
XZ
Liu
Shao
S
Lei
Peng
P
Xiao
Jin
J
D002214:Capsules; D003487:Cyanoacrylates / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems; D053769:Nanocapsules / Q000737:chemistry*; D009828:Oleanolic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
D002214:Capsules; D003487:Cyanoacrylates; D004337:Drug Carriers; D053769:Nanocapsules; D011091:Polyesters; D009828:Oleanolic Acid