Ischemic stroke and neurogenesis in the subventricular zone.
The subventricular zone (SVZ) of the lateral ventricle contains neural stem and progenitor cells that generate neuroblasts, which migrate to the olfactory bulb where they differentiate into interneurons. Ischemic stroke induces neurogenesis in the SVZ and these cells migrate to the boundary of the ischemic lesion. This article reviews current data on cytokinetics, signaling pathways and vascular niche that are involved in processes of proliferation, differentiation, and migration of neural progenitor cells after stroke.
Zhang
Rui Lan
RL
Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA.
Zhang
Zheng Gang
ZG
Chopp
Michael
M
D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000473:pathology*; D049109:Cell Proliferation; D006801:Humans; D020547:Lateral Ventricles / Q000473:pathology*; D009457:Neuroglia / Q000473:pathology; D009474:Neurons / Q000473:pathology; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000473:pathology; D020521:Stroke / Q000209:etiology / Q000473:pathology*