Carbon nanotubes and mesenchymal stem cells: biocompatibility, proliferation and differentiation.
The synergy of the unique properties of carbon nanotubes (CNT) with the remarkable potential of human mesenchymal stem cells (hMSC) provides an exciting opportunity for novel therapeutic modalities. However, little is known about the impact of CNT on hMSC behavior. We report the effect of CNT on hMSC renewal, metabolic activity, and differentiation. Furthermore, we tracked the intracellular movement of CNT through the cytoplasm to a nuclear location and assessed effects on cellular ultra structure.
Mooney
Emma
E
National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Galway, Ireland.
Dockery
Peter
P
Greiser
Udo
U
Murphy
Mary
M
Barron
Valerie
V
D001672:Biocompatible Materials / Q000378:metabolism*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002478:Cells, Cultured; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism*; D046529:Microscopy, Electron, Transmission; D037742:Nanotubes, Carbon / Q000648:ultrastructure
D001672:Biocompatible Materials; D037742:Nanotubes, Carbon