title: Clinical efficacy of proton magnetic resonance spectroscopy (1H-MRS) in the diagnosis of localized prostate cancer.
abstract: BACKGROUND
  The objective of this study was to evaluate the efficacy of proton magnetic resonance spectroscopy (1H-MRS) in the detection of prostate cancer.
  
  
  METHODS
  The experimental group consisted of 20 patients with localized prostate cancer who underwent radical prostatectomy. The sensitivity, positive predictive value and accuracy of the detection of prostate cancer in the 12 sections of the peripheral zone were calculated for prostate biopsy alone, 1H-MRS alone and the combination of these methods, respectively.
  
  
  RESULTS
  The sensitivity, the positive predictive value, and the accuracy of the preoperative diagnosis of prostate cancer were 43.7%, 68.9% and 54.6%, respectively, with prostate biopsy alone; 60.6%, 87.8% and 71.4% with 1H-MRS alone; and 88.7%, 88.7% and 87.4% with the combination of biopsy and 1H-MRS, respectively. Combined use of biopsy and 1H-MRS significantly improved the sensitivity, positive predictive value and accuracy of the diagnosis.
  
  
  CONCLUSIONS
  1H-MRS together with biopsy might improve the diagnostic accuracy in prostate cancer.
authors.affiliation: Department of Urology, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Saito
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Kaminaga
authors.forename: Satoru
authors.initials: S
authors.lastname: Muto
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Ide
authors.forename: Koujiro
authors.initials: K
authors.lastname: Nishio
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kamiyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okada
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Terado
authors.forename: Shigeru
authors.initials: S
authors.lastname: Furui
authors.forename: Shigeo
authors.initials: S
authors.lastname: Horie
mesh_terms: D000368:Aged; D001706:Biopsy; D002794:Choline / Q000378:metabolism; D019343:Citric Acid / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D011522:Protons
chemical_list: D011522:Protons; D019343:Citric Acid; D003401:Creatine; D002794:Choline