Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer.
The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment.
Stein
Gary S
GS
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. gary.stein@umassmed.edu
Zaidi
Sayyed K
SK
Stein
Janet L
JL
Lian
Jane B
JB
van Wijnen
Andre J
AJ
Montecino
Martin
M
Young
Daniel W
DW
Javed
Amjad
A
Pratap
Jitesh
J
Choi
Je-Yong
JY
Ali
Syed A
SA
Pande
Sandhya
S
Hassan
Mohammad Q
MQ
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics*; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*; D014157:Transcription Factors / Q000378:metabolism
D014157:Transcription Factors