title: Mecp2 organizes juvenile social behavior in a sex-specific manner.
abstract: Methyl-CpG-binding protein 2 (MeCP2) binds methylated DNA and recruits corepressor proteins to modify chromatin and alter gene transcription. Mutations of the MECP2 gene can cause Rett syndrome, whereas subtle reductions of MeCP2 expression may be associated with male-dominated social and neurodevelopmental disorders. We report that transiently decreased amygdala Mecp2 expression during a sensitive period of brain sexual differentiation disrupts the organization of sex differences in juvenile social play behavior. Interestingly, neonatal treatment with Mecp2 small interfering RNA within the developing amygdala reduced juvenile social play behavior in males but not females. Reduced Mecp2 expression did not change juvenile sociability or anxiety-like behavior, suggesting that this disruption is associated with subtle behavioral modification. This suggests that Mecp2 may have an overlooked role in the organization of sexually dimorphic behaviors and that male juvenile behavior is particularly sensitive to Mecp2 disruption during this period of development.
authors.affiliation: Department of Psychology, and Neuroscience Training Program, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Kurian
authors.forename: Meaghan E
authors.initials: ME
authors.lastname: Bychowski
authors.forename: Robin M
authors.initials: RM
authors.lastname: Forbes-Lorman
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Auger
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Auger
mesh_terms: D000221:Adaptation, Ocular / Q000187:drug effects; D000679:Amygdala / Q000187:drug effects / Q000254:growth & development / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001007:Anxiety / Q000503:physiopathology; D001522:Behavior, Animal / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051783:Methyl-CpG-Binding Protein 2 / Q000235:genetics / Q000378:metabolism*; D011247:Pregnancy; D034741:RNA, Small Interfering / Q000494:pharmacology; D051381:Rats; D012727:Sex Characteristics; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D012919:Social Behavior
chemical_list: C497394:Mecp2 protein, rat; D051783:Methyl-CpG-Binding Protein 2; D034741:RNA, Small Interfering