gammadelta T cell selection: is anyone useless?
In this issue of Immunity, a study by Jensen et al. (2008) suggests that T cell-receptor engagement during development affects gammadelta T cell polarization toward either interferon-gamma or interleukin-17 production. This might underlie their unique innate ability to regulate inflammation.
Bonneville
Marc
M
INSERM U892, Nantes F-44035, France. bonnevil@nantes.inserm.fr
D000818:Animals; D002454:Cell Differentiation; D051379:Mice; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology
D016692:Receptors, Antigen, T-Cell, gamma-delta