title: Comparison of a pulsatile blood pump and a peristaltic roller pump during hemoperfusion treatment in a canine model of paraquat poisoning.
abstract: This study examined the treatment efficacy and the damage to the blood during hemoperfusion for treating paraquat poisoning using two blood pump mechanisms. Paraquat-poisoned animal models were prepared. A conventional hemodialysis machine, AK90, with a peristaltic roller pump and a cardiopulmonary support system, T-PLS, with a pulsatile blood pump were used during the animal experiments. A total of 12 dogs were treated with hemoperfusion using a charcoal column. Six dogs were treated with hemoperfusion and T-PLS, and the other six were treated with AK90. A paraquat dose of 30 mg/kg was administrated by an intravenous injection. Both pumps maintained blood flow rates of 125 mL/min measured by an ultrasonic flowmeter. For anticoagulation, heparin was administrated by an initial bolus (250 IU/kg) and a continuous injection (100 IU/kg/h). During the experiments, T-PLS and AK90 showed a similar toxin removal efficacy. Both devices decreased the plasma paraquat concentration to 10% of the initial dose within 4-h hemoperfusion. The two pumps showed similar hemolysis properties with acceptable levels. Although T-PLS was developed as a cardiopulmonary bypass system, it can also be used as a hemoperfusion treatment device.
authors.affiliation: Interdisciplinary Program in Medical and Biological Engineering Major, Graduate School, Seoul National University, Seoul, Korea.
authors.forename: Jung Chan
authors.initials: JC
authors.lastname: Lee
authors.forename: Chan Young
authors.initials: CY
authors.lastname: Park
authors.forename: Seong Wook
authors.initials: SW
authors.lastname: Choi
authors.forename: Jeong Chul
authors.initials: JC
authors.lastname: Kim
authors.forename: Ki Moo
authors.initials: KM
authors.lastname: Lim
authors.forename: Kyuseok
authors.initials: K
authors.lastname: Kim
authors.forename: Sung Koo
authors.initials: SK
authors.lastname: Jung
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kwak
authors.forename: Sang Do
authors.initials: SD
authors.lastname: Shin
authors.forename: Ik Joon
authors.initials: IJ
authors.lastname: Jo
authors.forename: Gil Joon
authors.initials: GJ
authors.lastname: Suh
authors.forename: Byoung Goo
authors.initials: BG
authors.lastname: Min
mesh_terms: D000818:Animals; D002606:Charcoal / Q000627:therapeutic use; D004285:Dogs; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006461:Hemolysis; D006464:Hemoperfusion / Q000295:instrumentation*; D010269:Paraquat / Q000097:blood* / Q000506:poisoning*; D011673:Pulsatile Flow
chemical_list: D002606:Charcoal; D010269:Paraquat