title: Amelogenesis imperfecta - a systematic literature review of associated dental and oro-facial abnormalities and their impact on patients.
abstract: OBJECTIVE
  Amelogenesis imperfecta (AI) is a disease primarily affecting amelogenesis, but other aberrations have been reported. The purposes of this review were: (1) to identify other anomalies associated with AI, and (2) to describe the impact of the disease and its associated conditions on the oral health-related quality of life of patients, and the economic consequences.
  
  
  METHODS
  A literature search was conducted in the following databases: PubMed, EMBASE, Bibliotek.dk, The Cochrane Library, Web of Science, and OMIM, supplemented by a search for selected authors. Based on titles and abstracts, 137 papers were identified.
  
  
  RESULTS
  Most articles were case reports or case series with few cases. Aberrations were reported in the eruption process, in the morphology of the crown, in the pulp-dentine organ, and in the number of teeth. Gingival conditions and oral hygiene were usually reported to be poor, and calculus was a common finding. Open bite was the most commonly reported malocclusion. A negative impact on patients' oral health-related quality of life was described, but information was scarce. No information was found on the economic impact.
  
  
  CONCLUSIONS
  A number of aberrations associated with AI have been reported, but not sufficiently systematic to allow for a secondary analysis and synthesis of the findings. The impact on patients in terms of reduced quality of life and economic burden needs to be studied.
authors.affiliation: Department of Pediatric Dentistry, School of Dentistry, Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark. spoulsen@odont.au.dk
authors.forename: Sven
authors.initials: S
authors.lastname: Poulsen
authors.forename: Hans
authors.initials: H
authors.lastname: Gjørup
authors.forename: Dorte
authors.initials: D
authors.lastname: Haubek
authors.forename: Gro
authors.initials: G
authors.lastname: Haukali
authors.forename: Hanne
authors.initials: H
authors.lastname: Hintze
authors.forename: Henrik
authors.initials: H
authors.lastname: Løvschall
authors.forename: Marie
authors.initials: M
authors.lastname: Errboe
mesh_terms: D000567:Amelogenesis Imperfecta / Q000150:complications* / Q000191:economics / Q000523:psychology; D017281:Cost of Illness; D006801:Humans; D008310:Malocclusion / Q000150:complications; D010510:Periodontal Diseases / Q000150:complications; D011788:Quality of Life; D014071:Tooth Abnormalities / Q000150:complications