Glycomimetics and glycodendrimers as high affinity microbial anti-adhesins.
Adhesion to epithelial surface is often the first step in bacterial and viral infection. In this process, the microbes use a variety of proteins for interaction with host carbohydrates presented as glycoconjugates on cell surfaces. Crystal structures of adhesin and lectin binding sites in complexes with oligosaccharide open the route for design and synthesis of glycomimetics, glycodendrimers, and glycopolymers that are able to block infection at an early stage.
Imberty
Anne
A
CERMAV CNRS/Université Joseph Fourier, Grenoble cedex 9, France. imberty@cermav.cnrs.fr
Chabre
Yoann M
YM
Roy
René
R
D018829:Adhesins, Bacterial / Q000737:chemistry / Q000187:drug effects*; D001422:Bacterial Adhesion / Q000187:drug effects*; D001665:Binding Sites; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000737:chemistry / Q000187:drug effects; D006027:Glycosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D037102:Lectins / Q000737:chemistry / Q000187:drug effects*; D008958:Models, Molecular; D018716:Molecular Mimicry; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000737:chemistry / Q000187:drug effects; D011956:Receptors, Cell Surface / Q000187:drug effects
D018829:Adhesins, Bacterial; D050091:Dendrimers; D006027:Glycosides; D037102:Lectins; D009844:Oligosaccharides; D011108:Polymers; D011956:Receptors, Cell Surface