Normal perfusion pressure hyperperfusion in cerebral arteriovenous malformation surgery: model study on the hemodynamics and mechanisms.
A simulation study was undertaken using a compartmental flow model of a large high-flow cerebral arteriovenous malformation to investigate the hemodynamic changes during obliteration procedures. Under certain autoregulatory conditions, marked hyperperfusion (92 ml/100 g/min) could be induced in association with increased wall stress of the arterioles. Narrowing of the autoregulatory pressure range and its shift to a low pressure level are suspected to be among the possible causes of normal perfusion pressure breakthrough phenomenon.
Nagasawa
S
S
Department of Neurosurgery, Osaka Medical College, Takatsuki, Japan.
Kawanishi
M
M
Kondoh
S
S
Yamaguchi
K
K
Kajimoto
S
S
Tada
Y
Y
Ohta
T
T