Estimation of the potential antitumor activity of microencapsulated Lactobacillus acidophilus yogurt formulation in the attenuation of tumorigenesis in Apc(Min/+) mice.
There is a strong correlation between orally administered probiotics and suppression of the low-grade inflammation that can lead to restoration of normal local immune functions. We studied the potential immunomodulatory and antitumorigenic properties of microencapsulated probiotic bacterial cells in a yogurt formulation in Min mice carrying a germline APC mutation. Daily oral administration of microencapsulated Lactobacillus acidophilus bacterial cells in the yogurt formulation mice resulted in significant suppression of colon tumor incidence, tumor multiplicity, and reduced tumor size. Results show that oral administration of microencapsulated L. acidophilus contributed to the stabilization of animal body weight and decreased the release of bile acids. Histopathological analyses revealed fewer adenomas in treated versus untreated animals. Furthermore, treated animals exhibited fewer gastrointestinal intra-epithelial neoplasias with a lower grade of dysplasia in detected tumors. Results suggest that oral administration of microencapsulated probiotic L. acidophilus exerts anti-tumorous activity, which consequently leads to reduced tumor outcome.
Urbanska
Aleksandra Malgorzata
AM
Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, Canada.
Bhathena
Jasmine
J
Martoni
Christopher
C
Prakash
Satya
S
D000236:Adenoma / Q000145:classification / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D003106:Colon / Q000473:pathology; D015179:Colorectal Neoplasms / Q000145:classification / Q000473:pathology / Q000517:prevention & control*; D004339:Drug Compounding; D005243:Feces / Q000737:chemistry; D017491:Genes, APC; D015850:Interleukin-6 / Q000097:blood; D007779:Lactobacillus acidophilus; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009780:Occult Blood; D019936:Probiotics / Q000008:administration & dosage*; D015014:Yogurt / Q000382:microbiology*
D001647:Bile Acids and Salts; D015850:Interleukin-6