title: Comment on "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea".
abstract: Berg et al. (Reports, 14 December 2007, p. 1782) reported the discovery of an autotrophic carbon dioxide-fixation pathway in Archaea and implicated a substantial role of this pathway in global carbon cycling based on sequence analysis of Global Ocean Sampling data. We question the validity of the latter claim.
authors.affiliation: Department of Molecular Evolution, Evolutionary Biology Centre, Uppsala University, Uppsala, S-752 36 Sweden. thijs.ettema@ebc.uu.se
authors.forename: Thijs J G
authors.initials: TJ
authors.lastname: Ettema
authors.forename: Siv G E
authors.initials: SG
authors.lastname: Andersson
mesh_terms: D001105:Archaea / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D052818:Autotrophic Processes; D001421:Bacteria, Anaerobic / Q000145:classification / Q000235:genetics / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism*; D006836:Hydro-Lyases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000378:metabolism*; D019344:Lactic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D009792:Oceans and Seas; D010802:Phylogeny; D012623:Seawater / Q000382:microbiology*
chemical_list: D006885:Hydroxybutyrates; D002245:Carbon Dioxide; C111420:4-hydroxybutyric acid; D019344:Lactic Acid; C031601:hydracrylic acid; C066370:4-hydroxybutyryl-CoA dehydratase; D006836:Hydro-Lyases