Harvesting the mouse genome.
The sequencing of the black 6 mouse (strain C57Bl/6) has reached an important juncture. The BAC fingerprint map is almost complete, the BACs have been endsequenced and a seven-fold coverage whole-genome shotgun has been assembled. Now the BAC-by-BAC sequencing phase is under way and in-depth comparative analysis can be carried out on regions that have been the subject of targeted sequencing. This paper reviews the progress so far and looks forward to the promises of finished sequence.
Botcherby
Marc
M
MRC UK HGMP Resource Centre, Genome Campus, Hinxton, Cambridge CB10 1SB, UK. mrbotche@hgmp.mrc.ac.uk