title: Ginkgo biloba (EGb 761) extract: effects on the myenteric plexus of the large intestine in Wistar rats.
abstract: The objective of this study was to evaluate the effect of the purified extract of the Ginkgo biloba (EGb 761) plant on the myenteric plexus in the proximal and distal colon of Wistar rats for a period of 120 days. The experimental rats were divided into two age groups: a young group, sacrificed at age 90 days, and an adult group, sacrificed at age 210 days. We observed a significant reduction in the number of neurons in the myenteric plexus of the adult group compared to the young group in both of the segments studied (P < 0.01). The adult group treated with Ginkgo biloba showed a significant increase in neuronal profile area in both the segments studied (P < 0.001). It can be concluded from these results that treatment with the purified Ginkgo biloba (EGb 761) plant extract at a dose of 50 mg/kg body weight has neurotrophic effect on the myenteric plexus in the proximal and distal colon of rats after 120 days of treatment.
authors.affiliation: Department of Morphophysiological Sciences, Universidade Estadual de Maringá, Av. Colombo, 5790 Bloco, H-79-CEP, 87020-900, Maringa, PR, Brazil.
authors.forename: Glasiella Gonzalez
authors.initials: GG
authors.lastname: Perez
authors.forename: Larissa Carla Lauer
authors.initials: LC
authors.lastname: Schneider
authors.forename: Nilza Cristina
authors.initials: NC
authors.lastname: Buttow
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000473:pathology; D000818:Animals; D003106:Colon / Q000187:drug effects* / Q000294:innervation; D020441:Ginkgo biloba; D008297:Male; D009197:Myenteric Plexus / Q000166:cytology / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000096983:Ginkgo Extract
chemical_list: D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract