Novel effects of Nelumbo nucifera rhizome extract on memory and neurogenesis in the dentate gyrus of the rat hippocampus.
Memory enhancement is a matter of concern in general, and in particular to people suffering from cognitive dysfunction. In this study, we investigated the effect of Nelumbo nucifera rhizome extract on learning and memory function. A step-through passive avoidance test was performed with Wistar rats. In addition, immunohistochemistry was used to investigate cell proliferation and differentiation in the dentate gyrus of the hippocampus. The methanol extract of N. nucifera rhizome (MNR) resulted in significant improvements of memory functions and neurogenesis in the dentate gyrus. In the passive avoidance test, the retention time of MNR-treated rats was significantly longer than that of controls. Immunohistochemical analyses using BrdU, Ki-67, and DCX showed significantly increased cell proliferation and cell differentiation in the dentate gyrus. These results suggest that N. nucifera rhizome extract may improve learning and memory with enhancing neurogenesis in the DG of the hippocampus.
Yang
Woong Mo
WM
Department of Prescriptionology, Kyung Hee University, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
Shim
Kyung Jun
KJ
Choi
Moon Jung
MJ
Park
Soo Yeon
SY
Choi
Bong-Jae
BJ
Chang
Mun Seog
MS
Park
Seong Kyu
SK
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D018891:Dentate Gyrus / Q000187:drug effects*; D000089662:Doublecortin Protein; D007150:Immunohistochemistry; D008568:Memory / Q000187:drug effects*; D031653:Nelumbo / Q000737:chemistry*; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D027343:Rhizome / Q000737:chemistry*
C000714848:Dcx protein, rat; D000089662:Doublecortin Protein; D010936:Plant Extracts