[The influence of polyvitamin complex polijen on mutagenic and cytotoxic effect of copper oxychloride in white mice].
The present study investigates antimutagenic and anticytotoxic effect of polyvitamin complex Polijen in laboratory mice. Mutation in mice was induced by pesticide - copper oxychloride 3Cu(OH)2 CuCl2 , which is characterizes by the mutagenic and cytotoxic effect. Introduction of copper oxychloride (dosage 1/2, 1/5, 1/10 LD50) per oral to animals induces strong increase (p<0,001) of frequency of chromosomal aberrations (multiple fragments, lyses), genomic mutations (triploidy, tetraploidy), pathological mitosis (hollow metaphase, K-mitosis, adhesion of chromosomes) and destruction of interphase nucleuses (hollow nucleus). Experiments showed that administration of polyvitamin complex Polijen decreased 2, 5 times mutagenic and cytotoxic effect of pesticide-copper oxychloride.
Pirtskhelani
A G
AG
Pirtskhelani
N A
NA
Gakhokidze
R A
RA
Bichikashvili
N V
NV
Kalandiia
E A
EA
D000818:Animals; D002869:Chromosome Aberrations / Q000139:chemically induced / Q000187:drug effects*; D003300:Copper / Q000633:toxicity*; D004195:Disease Models, Animal; D051379:Mice; D009154:Mutation / Q000187:drug effects*; D016896:Treatment Outcome; D014815:Vitamins / Q000627:therapeutic use*
D014815:Vitamins; C007120:copper oxychloride; D003300:Copper