Molecular imaging of PET reporter gene expression.
Multimodality molecular imaging continues to rapidly expand and is impacting many areas of biomedical research as well as patient management. Reporter-gene assays have emerged as a very general strategy for indirectly monitoring various intracellular events. Furthermore, reporter genes are being used to monitor gene/cell therapies, including the location(s), time variation, and magnitude of gene expression. This chapter reviews reporter gene technology and its major pre-clinical and clinical applications to date. The future appears quite promising for the continued expansion of the use of reporter genes in many evolving biomedically related arenas.
Min
Jung-Joon
JJ
Department of Nuclear Medicine, Chonnam National University Medical School, 160 Ilsimri, Hwasun, Jeonnam 519-809, Republic of Korea. jjmin@jnu.ac.kr
Gambhir
Sanjiv S
SS
D000818:Animals; D002465:Cell Movement; D017690:Cell Transplantation; D005786:Gene Expression Regulation; D018390:Gene Targeting; D018014:Gene Transfer Techniques; D017930:Genes, Reporter; D015316:Genetic Therapy; D006801:Humans; D025202:Molecular Diagnostic Techniques; D015335:Molecular Probes / Q000235:genetics / Q000378:metabolism*; D049268:Positron-Emission Tomography; D012815:Signal Processing, Computer-Assisted
D015335:Molecular Probes