title: Pravastatin-induced colitis.
abstract: We report an unusual case of pravastatin-induced colitis in an 80-year old lady. Onset of symptoms was noted within 48 h of starting the medication. Colonoscopy revealed diffuse ulceration throughout the colon with relative sparing of the rectum, with the biopsies showing ulceration and inflammation. The patient received a short course of steroid therapy and 5 months after stopping pravastatin, there was complete macroscopic and microscopic resolution of the colonic lesions. Drug interaction of pravastatin with amitryptiline could have resulted in this uncommon complication.
authors.affiliation: Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK.
authors.forename: Ashis
authors.initials: A
authors.lastname: Mukhopadhya
authors.forename: Hugh
authors.initials: H
authors.lastname: Gilmour
authors.forename: John
authors.initials: J
authors.lastname: Plevris
mesh_terms: D000369:Aged, 80 and over; D003092:Colitis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D017035:Pravastatin / Q000009:adverse effects*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017035:Pravastatin