Epigenetic regulation of stem cell fate.
Stem cell-based regenerative medicine holds great promise for repair of diseased tissue. Modern directions in the field of epigenetic research aimed to decipher the epigenetic signals that give stem cells their unique ability to self-renew and differentiate into different cell types. However, this research is only the tip of the iceberg when it comes to writing an 'epigenetic instruction manual' for the ramification of molecular details of cell commitment and differentiation. In this review, we discuss the impact of the epigenetic research on our understanding of stem cell biology.
Lunyak
Victoria V
VV
Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA. vlunyak@buckinstitute.org
Rosenfeld
Michael G
MG
D000818:Animals; D002454:Cell Differentiation; D044127:Epigenesis, Genetic; D053263:Gene Regulatory Networks; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism; D044968:Regenerative Medicine; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D006657:Histones; D022661:RNA, Untranslated; D014157:Transcription Factors