title: Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii.
abstract: Bacteria of the genus Acinetobacter spp. are rapidly emerging as problematic pathogens in healthcare settings. This is exacerbated by the bacteria's ability to form robust biofilms. Marine natural products incorporating a 2-aminoimidazole (2-AI) motif, namely from the oroidin class of marine alkaloids, have served as a unique scaffold for developing molecules that have the ability to inhibit and disperse bacterial biofilms. Herein we present the anti-biofilm activity of a small library of second generation oroidin analogues against the bacterium Acinetobacter baumannii.
authors.affiliation: North Carolina State University, Department of Chemistry, 2620 Yarborough Drive, Raleigh, NC 27695-8204, USA.
authors.forename: Justin J
authors.initials: JJ
authors.lastname: Richards
authors.forename: Catherine S
authors.initials: CS
authors.lastname: Reed
authors.forename: Christian
authors.initials: C
authors.lastname: Melander
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000254:growth & development; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D054852:Small Molecule Libraries; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D007093:Imidazoles; D011758:Pyrroles; D054852:Small Molecule Libraries; C014973:2-aminoimidazole; C077209:oroidin