Trans-species assessment of antidepressant activity in a rodent model of depression.
Olfactory bulbectomy (OB), a preclinical model of depression, has most often been performed and validated in rats, but not as comprehensively in other rodent species. This study demonstrated that bulbectomy induced a hyperactive response in the open field test in three rodent species, namely the rat, mouse and hamster. OB, in all species, produced an increase in the distance travelled in the perimeter of the arena. The OB mouse was the only species to demonstrate increased distance travelled in the central part of the arena. These behavioral disturbances were attenuated in all species following chronic treatment with the antidepressant imipramine.
Roche
Michelle
M
Department of Pharmacology and Therapeutics, National University of Ireland Galway, University Road, Galway, Ireland. michelle.roche@nuigalway.ie
Shanahan
Eamonn
E
Harkin
Andrew
A
Kelly
John P
JP
D000704:Analysis of Variance; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D006224:Cricetinae; D003863:Depression / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D004195:Disease Models, Animal; D007099:Imipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009830:Olfactory Bulb / Q000601:surgery; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D013997:Time Factors
D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine