title: Considerations on the physiopathological mechanism of inner ear damage induced by intravenous cocaine abuse: cues from a case report.
abstract: OBJECTIVE
  Aim of the following paper is to discuss about the possible etiopathogenetic mechanisms of inner ear damage induced by cocaine abuse. Unfortunately the data concerning this topic are very limited; the authors are then presenting a literature review, also discussing the clinical presentation and the possible therapeutical approach of a clinical case of bilateral sudden sensorineural hearing loss following i.v. injection of cocaine.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A strictly audiological evaluation has been performed, in order to identify the cochlear lesion site(s) and to provide the best medical treatment.
  
  
  CONCLUSIONS
  To our knowledge, this is the first report of acute cocaine intoxication with sudden bilateral hearing loss. Further studies are required in order to understand the effects of these substances on the inner ear cells and metabolism.
authors.affiliation: U.O. di Audiologia, University of Ferrara, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ciorba
authors.forename: R
authors.initials: R
authors.lastname: Bovo
authors.forename: S
authors.initials: S
authors.lastname: Prosser
authors.forename: A
authors.initials: A
authors.lastname: Martini
mesh_terms: D000328:Adult; D001309:Auditory Threshold / Q000187:drug effects; D001623:Betamethasone / Q000008:administration & dosage; D003042:Cocaine / Q000633:toxicity*; D019970:Cocaine-Related Disorders / Q000150:complications*; D018765:Dopamine Uptake Inhibitors / Q000633:toxicity*; D004359:Drug Therapy, Combination; D007758:Ear, Inner / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D003639:Hearing Loss, Sudden / Q000139:chemically induced* / Q000188:drug therapy; D006320:Hearing Tests; D006801:Humans; D008353:Mannitol / Q000008:administration & dosage; D015819:Substance Abuse, Intravenous / Q000150:complications*
chemical_list: D018765:Dopamine Uptake Inhibitors; D008353:Mannitol; D001623:Betamethasone; D003042:Cocaine