title: Genomic changes in progression of low-grade gliomas.
abstract: Using a one-megabase BAC-based array comparative genomic hybridization technique (aCGH), we have investigated a series of 16 low-grade gliomas (LGGs) and their subsequent progression to higher-grade malignancies. The most frequent chromosome imbalances in primary tumors were gains of chromosomes 7q, 8q, and 22q, and losses of chromosomes 1p, 13q, and 19q. In tumor progression, gains of chromosomes 11q, 7q, 20q, and 21q, and losses of chromosomes 9p, including CDKN2A locus, 19q, 14q, 1p, and 6q were the most frequent genomic disequilibria. Progressive tumors were more imbalanced than primary tumors in terms of altered chromosomal arms (3.8 vs. 6.6 in mean abnormal chromosomal arm) and altered BACs (17 vs. 21%). Interestingly, putative novel candidate genes associated with glioma progression were identified, in particular DOCK8, PTPRD, CER1, TPHO, DHFR, MSH3, ETS1, ACACA, and CSE1L.
authors.affiliation: INSERM Unité 711, Paris, France. ahmed.idbaih@gmail.com
authors.forename: Ahmed
authors.initials: A
authors.lastname: Idbaih
authors.forename: Rosana
authors.initials: R
authors.lastname: Carvalho Silva
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Crinière
authors.forename: Yannick
authors.initials: Y
authors.lastname: Marie
authors.forename: Catherine
authors.initials: C
authors.lastname: Carpentier
authors.forename: Blandine
authors.initials: B
authors.lastname: Boisselier
authors.forename: Sophie
authors.initials: S
authors.lastname: Taillibert
authors.forename: Audrey
authors.initials: A
authors.lastname: Rousseau
authors.forename: Karima
authors.initials: K
authors.lastname: Mokhtari
authors.forename: François
authors.initials: F
authors.lastname: Ducray
authors.forename: Joelle
authors.initials: J
authors.lastname: Thillet
authors.forename: Marc
authors.initials: M
authors.lastname: Sanson
authors.forename: Khê
authors.initials: K
authors.lastname: Hoang-Xuan
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Delattre
mesh_terms: D000328:Adult; D002872:Chromosome Deletion; D002875:Chromosomes; D018450:Disease Progression; D005260:Female; D016678:Genome / Q000235:genetics*; D005910:Glioma / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009693:Nucleic Acid Hybridization / Q000379:methods