Novel N,N,P-tridentate ligands for the highly enantioselective copper-catalyzed 1,4-addition of dialkylzincs to enones.
Use of 0.25 mol % of the N, N, P-tridentate ligand containing the 2-quinolyl moiety ( 1 and 2) and 0.1 mol % of Cu(OTf) 2 enabled the enantioselective 1,4-addition of dialkylzincs to cyclic enones to produce 1,4-adducts in up to 99% ee.
Kawamura
Kenjiro
K
Department of Chemistry, Graduate School of Science, Kobe University, Kobe 657-8501, Japan.
Fukuzawa
Hitomi
H
Hayashi
Masahiko
M
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry*; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
D007659:Ketones; D008024:Ligands; D009942:Organometallic Compounds; D012545:Schiff Bases; D003300:Copper; D015032:Zinc