title: LC-9018 treatment enhances survival in gram-negative burn wound sepsis.
abstract: Mice pretreated with the LC-9018 showed enhanced survival compared to controls when burned and infected with P. aeruginosa and K. pneumoniae strains. Burned skin quantitative bacterial counts in LC-9018 treated and controls were similar but kidney and liver counts of treated mice were significantly lower. Increased peritoneal cell counts in LC-9018 treated groups suggested enhanced survival and lower organ counts resulted from increased microbial clearance. Survival in LC-9018 pretreated P. aeruginosa infected burned mice was reduced in neutropenic or macrophage blockaded mice which supported this hypothesis. Burned mice treated with LC-9018 at times postburn but pre-P. aeruginosa infection showed significantly enhanced survival. Thus LC-9018 treatment might be useful for increasing survival from burn wound sepsis and further investigation is warranted.
authors.affiliation: Shriners Burns Institute, 3229 Bumet Avenue, Cincinnati, OH 45229, USA.
authors.forename: I A
authors.initials: IA
authors.lastname: Holder
authors.forename: R G
authors.initials: RG
authors.lastname: Miller
authors.forename: A N
authors.initials: AN
authors.lastname: Neely