Properties of mouse leukemia viruses. XIV. Prevention of spontaneous AKR leukemia by treatment with group-specific antibody against the major virus gp71 glycoprotein.
Treatment of AKR mice early in life with potent goat antibody to the major virus glycoprotein (gp71) of Friend leukemia virus resulted in marked prevention of fatal AKR disease. Even better protection could be achieved when, in addition, the mothers were treated with the same antibody at least 3-4 days antepartum. From these preliminary observations, we conclude that antibody specific for the broadly cross-reacting determinants of this virus glycoprotein can control development of spontaneous leukemias mediated by replicating endogenous viruses.
Schäfer
W
W
Max-Planck-Institut für Virusforschung, 7400 Tübingen, Germany.
Schwarz
H
H
Thiel
H J
HJ
Fischinger
P J
PJ
Bolognesi
D P
DP