title: [A series of 618 cases of monoclonal gammopathies of undetermined significance: predictive factors of disappearance of monoclonal component or evolution to malignant gammopathies].
abstract: BACKGROUND
  How to identify monoclonal gammopathies of undeterminated significance (MGUS) at risk for progression has been studied for the last years.
  
  
  OBJECTIVE
  To study the incidence of MGUS in a region with 300,000 inhabitants and factors which associate with a) monoclonal gammopathy disappearance (transient MGUS) b) evolution to malignant gammopathy.
  
  
  METHODS
  Study of 618 MGUS.
  
  
  RESULTS
  Incidence: 30/40 new cases a year with increase to 70 cases a years in the latest years of study. Age and gender: 71,4 y (32-100), male/female ratio 1.4. Associated pathology: infection 328, heart diseases 249, rheumatic diseases 211, liver diseases 108, cancer 80, neuropathy 43. Monoclonal proteins: IgG 407, IgM 78, IgD 2, biclonal 16, triclonal 1; no heavy chain 21, light chain Kappa 389. Variables (mean): monoclonal component: 14 g/l, ESR 32,5, bone marrow: 5,9% plasma cells beta2-microglobulin: 2,59 mg/l, albumin: 3,1g/l, bone survey: normal 39,5%. Evolution: transient MGUS 20 cases. Time to disappearance 2,6 months (1,4-4,6). Evolution to malignant gammopathy 24 cases, time to progression 3 years (IC 1,82-4,3).
  
  
  RESULTS
  Several factors were associatedç with malignant transformation: heavy chain IgA (p < 0,002), ESR (p < 0,001), age < 70 (p < 0,05), bone marrow percentage of plasma cells (p < 0,002) y ostheoporosis (p < 0,005). A MGUS follow up model is suggested.
authors.affiliation: Servicio de Hematología-Hemoterapia, Hospital de Cabueñes, Gijón, Asturias, España. esthergongar@yahoo.es
authors.forename: M E
authors.initials: ME
authors.lastname: González García
authors.forename: C
authors.initials: C
authors.lastname: Fernández Alvarez
authors.forename: V
authors.initials: V
authors.lastname: Robles Marinas
authors.forename: A J
authors.initials: AJ
authors.lastname: González Huerta
authors.forename: M I
authors.initials: MI
authors.lastname: Arias Miranda
authors.forename: A P
authors.initials: AP
authors.lastname: González Rodríguez
authors.forename: J
authors.initials: J
authors.lastname: García Casas
authors.forename: J Moris
authors.initials: JM
authors.lastname: de La Tassa
authors.forename: J
authors.initials: J
authors.lastname: Fernández García
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000453:epidemiology* / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors