title: Self-assembly of perfunctionalized beta-cyclodextrins on a quartz crystal microbalance for real-time chiral recognition.
abstract: This study reports the development of novel chiral sensors based on the self-assembly of perfunctionalized beta-cyclodextrins (beta-CD) on a quartz crystal microbalance transducer for real time chiral recognition. Ten chiral sensors immobilized with mercaptyl perfunctionalized beta-cyclodextrins were found to exhibit promising enantioselectivity in the gas phase. Well-defined sizes of molecular cavities of the modified beta-CDs associated with cooperative weak interactions with the host molecules afforded enhanced chiral discrimination. This study contributes to the realization of novel chiral sensors applicable for real-time recognition and analysis of enantiomeric alcohols and lactates.
authors.affiliation: Department of Chemistry, National University of Singapore, Singapore.
authors.forename: Changhua
authors.initials: C
authors.lastname: Xu
authors.forename: Siu Choon
authors.initials: SC
authors.lastname: Ng
authors.forename: Hardy Sze On
authors.initials: HS
authors.lastname: Chan
mesh_terms: D003460:Crystallization; D007773:Lactates / Q000737:chemistry; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D015394:Molecular Structure; D011791:Quartz; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013499:Surface Properties; D013997:Time Factors; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D007773:Lactates; D013438:Sulfhydryl Compounds; D047392:beta-Cyclodextrins; C028444:methyl lactate; D011791:Quartz