title: Comparable outcomes of HLA-matched unrelated and HLA-identical sibling donor bone marrow transplantation for childhood acute myeloid leukemia in first remission.
abstract: We retrospectively investigated the outcomes of HLA-matched unrelated BMT (MU-BMT, n = 13) and HLA-identical sibling donor BMT (MS-BMT, n = 17) for childhood AML in CR1 between June 2002 and August 2005. Engraftment of neutrophil and platelet did not differ between the two transplant groups. The cumulative incidence of grade II-IV acute GVHD and any chronic GVHD at three yr was not different between MS-BMT and MU-BMT. Of the 30 patients, four patients experienced relapses (three with MS-BMT, one with MU-BMT) and four patients died of transplant-related complications (two with MS-BMT, two with MU-BMT). A total of 23 patients survived with a median follow-up of 43.2 months. The Kaplan-Meier estimates for EFS rates at three yr were 71% and 77% for MS-BMT and MU-BMT, respectively, and the OS rates were 76% and 77% for MS-BMT and MU-BMT, respectively. The outcome of HLA-matched unrelated BMT is comparable to that of HLA-identical sibling BMT for childhood AML in CR1. HLA-matched unrelated BMT may be recommended for patients who have AML in CR1 without an HLA-matched sibling donor.
authors.affiliation: Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea.
authors.forename: Dae-Hyoung
authors.initials: DH
authors.lastname: Lee
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Kwon
authors.forename: Jihyang
authors.initials: J
authors.lastname: Lim
authors.forename: Yonggoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Kyungja
authors.initials: K
authors.lastname: Han
authors.forename: Nak-Gyun
authors.initials: NG
authors.lastname: Chung
authors.forename: Dae-Chul
authors.initials: DC
authors.lastname: Jeong
authors.forename: Bin
authors.initials: B
authors.lastname: Cho
authors.forename: Hack-Ki
authors.initials: HK
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D016026:Bone Marrow Transplantation / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000378:metabolism*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D019520:Living Donors; D008297:Male; D009504:Neutrophils / Q000378:metabolism; D012074:Remission Induction; D012189:Retrospective Studies; D035781:Siblings; D016896:Treatment Outcome
chemical_list: D006680:HLA Antigens