Single-nucleotide polymorphisms in human beta-defensin-1 gene in Mozambican HIV-1-infected women and correlation with virologic parameters.
We analyzed single nucleotide polymorphisms in the 5'-untranslated region (-44C/G and -52G/A) of the beta-defensin-1 gene in 78 Mozambican HIV-1-infected mothers. We observed significantly lower levels of HIV-1 RNA in breast milk, but not in plasma, in women with the -52GG genotype versus women with the -52GA and -52AA genotypes, supporting the hypothesis that different expression of beta-defensins could have an impact on viral replication in breast milk.
Baroncelli
Silvia
S
Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Rome, Italy. silvia.baroncelli@iss.it
Ricci
Elisabetta
E
Andreotti
Mauro
M
Guidotti
Giovanni
G
Germano
Paola
P
Marazzi
Maria Cristina
MC
Vella
Stefano
S
Palombi
Leonardo
L
De Rossi
Anita
A
Giuliano
Marina
M
D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D008895:Milk, Human / Q000821:virology; D020641:Polymorphism, Single Nucleotide; D012367:RNA, Viral / Q000032:analysis; D019562:Viral Load; D023083:beta-Defensins / Q000235:genetics*
C406407:DEFB1 protein, human; D012367:RNA, Viral; D023083:beta-Defensins