Perioperative plasma brain natriuretic peptide and cardiotrophin-1 in off-pump coronary artery bypass.
OBJECTIVE
It has been suggested that brain natriuretic peptide (BNP) and cardiotrophin-1 (CT-1) are associated with myocardial dysfunction. The present prospective study was designed to investigate perioperative changes of plasma levels of BNP and CT-1 in off-pump coronary artery bypass (OPCAB).


METHODS
Forty-nine patients undergoing elective OPCAB were divided into three groups. Group I: no previous myocardial infarction; Group II: previous myocardial infarction more than 12 weeks; Group III: recent myocardial infarction within 4-8 weeks. Perioperative BNP and CT-1 levels were measured, and hematochemical parameters were also collected.


RESULTS
Higher preoperative BNP and CT-1 levels were found in group III as compared to those in group I. BNP levels increased after operation, and reached peak value at 3-7 days after the operation. However, the postoperative changes of BNP levels were not different among groups in any time points. CT-1 levels did not change significantly after the operation as compared to baseline.


CONCLUSIONS
Higher BNP and CT-1 levels were associated with recent myocardial infarction. BNP elevated after OPCAB, but CT-1 showed no significant postoperative changes. Postoperative changes of BNP and CT-1 do not associated with cardiac function in OPCAB.
Wei
Minxin
M
Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, P. R. China. minxinw@yahoo.com
Ren
Shuo
S
Liu
Jianshi
J
Li
Peijun
P
Qian
Hongyu
H
Tarkka
Matti
M
D000368:Aged; D015415:Biomarkers / Q000097:blood; D047549:Coronary Artery Bypass, Off-Pump; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D019990:Perioperative Care; D011446:Prospective Studies; D013997:Time Factors; D016277:Ventricular Function, Left
D015415:Biomarkers; D016207:Cytokines; D020097:Natriuretic Peptide, Brain; C092073:cardiotrophin 1