title: Implications of blood-brain barrier disruption in ALS.
abstract: Our letter to the editor addresses important questions regarding the role of the blood-spinal cord barrier in amyotrophic lateral sclerosis. The novel finding of barrier dysfunction in ALS has implications for disease pathogenesis. This discussion should prove of widespread interest to researchers and may help in formulating various new therapeutic strategies to protect barrier function and thus extend functionality and lifespan in ALS patients.
authors.forename: Svitlana
authors.initials: S
authors.lastname: Garbuzova-Davis
authors.forename: Samuel
authors.initials: S
authors.lastname: Saporta
authors.forename: Paul R
authors.initials: PR
authors.lastname: Sanberg
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics / Q000503:physiopathology*; D001812:Blood-Brain Barrier / Q000503:physiopathology*; D006801:Humans