Traditional and alternative designs for pulmonary arterial hypertension trials.
This article elaborates on the phases of drug development and trial design for pulmonary arterial hypertension, emphasizing the need for learning trials to assess efficacy signals before confirming trials. In this new era in pulmonary arterial hypertension, we need to reconsider innovative trial designs to maximize efficiency and pursue agents with the greatest potential for cure.
Gomberg-Maitland
Mardi
M
University of Chicago Medical Center, Section of Cardiology, MC2016, 5841 S. Maryland Ave., Chicago, IL 60637, USA. mgomberg@medicine.bsd.uchicago.edu
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D015203:Reproducibility of Results
D000959:Antihypertensive Agents