Targeting intercellular signals for bone regeneration from bone marrow mesenchymal progenitors.
There are tremendous unmet clinical needs for effective strategies to enhance bone regeneration in vivo. The sustained presence of multipotent mesenchymal progenitors in the bone marrow in aged and osteoporotic individuals offers the potential for therapeutic interventions to induce osteoblast production from the resident progenitors. Recent advances in understanding the intercellular signals governing osteogenic decisions may provide targets for developing novel bone-enhancing therapeutics.
Long
Fanxin
F
Department of Medicine, Department of Developmental Biology, Washington Universtiy Medical School, St. Louis, Missouri 63110, USA. flong@wustl.edu
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology* / Q000378:metabolism; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D001861:Bone Regeneration; D002454:Cell Differentiation; D049109:Cell Proliferation; D005346:Fibroblast Growth Factors / Q000378:metabolism; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D010006:Osteoblasts / Q000166:cytology; D010012:Osteogenesis; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism
D019485:Bone Morphogenetic Proteins; D053823:Hedgehog Proteins; D051880:Receptors, Notch; D051153:Wnt Proteins; D005346:Fibroblast Growth Factors