Molecular basis of pluripotency.
Embryonic stem (ES) cells are pluripotent and capable of self-renewal, thus holding promise for regenerative medicine. Recent studies have begun to provide insights into the molecular mechanisms underlying pluripotency and self-renewal. In this article, we discuss the roles of transcriptional regulation, epigenetic regulation and miRNAs in the maintenance of pluripotency and the differentiation of ES cells.
Chen
Lingyi
L
Division of Pediatric Hematology/Oncology, Children's Hospital Boston, Dana Farber Cancer Institute, Boston, MA 02115, USA.
Daley
George Q
GQ
D000818:Animals; D002454:Cell Differentiation; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000502:physiology*; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D039904:Pluripotent Stem Cells / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D002843:Chromatin; D035683:MicroRNAs; D014157:Transcription Factors