Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families.
Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present study based on 626 German familial non-HNPCC colorectal cancer patients and 736 healthy controls. No associations of any of the 10 nsSNPs with colorectal cancer could be replicated. The combined analyses indicated that further research based on additional independent samples is required.
Frank
Bernd
B
Helmholtz-University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany.
Burwinkel
Barbara
B
Bermejo
Justo Lorenzo
JL
Försti
Asta
A
Hemminki
Kari
K
Houlston
Richard
R
Mangold
Elisabeth
E
Rahner
Nils
N
Friedl
Waltraut
W
Friedrichs
Nicolaus
N
Buettner
Reinhard
R
Engel
Christoph
C
Loeffler
Markus
M
Holinski-Feder
Elke
E
Morak
Monika
M
Keller
Gisela
G
Schackert
Hans K
HK
Krüger
Stefan
S
Goecke
Timm
T
Moeslein
Gabriela
G
Kloor
Matthias
M
Gebert
Johannes
J
Kunstmann
Erdmute
E
Schulmann
Karsten
K
Rüschoff
Josef
J
Propping
Peter
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D015203:Reproducibility of Results