Clinicopathologic findings of colorectal traditional and sessile serrated adenomas in Korea: a multicenter study.
OBJECTIVE
Serrated polyps have emerged as important evidence supporting the serrated polyp-neoplasia pathway in colorectal carcinogenesis, an alternate to the classical adenoma-carcinoma sequence. However, there is confusion over the diagnostic criteria for serrated polyps including traditional serrated adenoma (TSA) and sessile serrated adenoma (SSA). In addition, clinical and pathologic characteristics of each are largely unknown and need further exploration.


METHODS
The 753 polyps that were previously diagnosed as serrated adenoma (SA) from 14 tertiary care university hospitals in Korea between 2003 and 2005 were evaluated for the clinicopathologic findings of TSA and SSA.


RESULTS
Among 753 cases, 420 (55.8%) were reclassified as TSA and 56 (7.4%) as SSA. Among the pathologic parameters, crypt branching, crypt dilatation, and horizontal crypts were more frequent in SSA than in TSA (p < 0.001). SSA was larger than TSA (12.6 +/- 7.3 vs. 9.8 +/- 6.9 mm, p = 0.005), was more likely to be flat type (p = 0.006), and was more frequently located in the proximal colorectum (p = 0.012). There were no significant differences in age, sex, and body mass index between TSA and SSA.


CONCLUSIONS
Locationand endoscopic features of the polyps with abnormal crypt morphology in histologic findings could be helpful for the diagnosis and classification of SAs.
Lee
Sang Kil
SK
Yonsei University College of Medicine, Institute of Gastroenterology, Seoul, Korea.
Chang
Hee Jin
HJ
Kim
Tae Il
TI
Kim
Won Ho
WH
Park
Cheol Keun
CK
Chang
Dong Kyung
DK
Park
Dong Il
DI
Sohn
Jin Hee
JH
Byeon
Jeong-Sik
JS
Yang
Suk-Kyun
SK
Kim
Jin Oh
JO
Lee
Suk-Ho
SH
Jin
So Young
SY
Park
Cheol Hee
CH
Baek
Il Hyun
IH
Eun
Chang Soo
CS
Han
Dong Soo
DS
Park
Seun Ja
SJ
Chang
Hee Kyung
HK
Jeen
Yoon Tae
YT
Kim
Hyun Soo
HS
Park
Dong Hoon
DH
Shin
Sung Jae
SJ
Chang
Mee Soo
MS
D000236:Adenoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity