A dog with acute myelomonocytic leukemia.
A three-year-old dog with marked leukocytosis, lymphadenopathy, and diarrhea showed an increase in unidentified blasts in the peripheral blood, and they were proliferated in the bone marrow. The dog was diagnosed with myelomonocytic leukemia (M4) because the blast cells were demonstrated by cytochemical staining to be both myeloid and monocytic cells. Although the dog was treated with a multi-combination chemotherapy and induction therapy using vitamin K2, it died on day 47 after the first admission. This case is the first report of M4 in Japan.
Hisasue
Masaharu
M
Laboratory of Veterinary Internal Medicine II, Azabu University, Kanagawa, Japan.
Nishimura
Tomomi
T
Neo
Sakurako
S
Nagashima
Naho
N
Ishikawa
Takefumi
T
Tsuchiya
Ryo
R
Yamada
Takatsugu
T
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003561:Cytarabine / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology*; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D006403:Hematologic Tests; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011239:Prednisolone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use; D014812:Vitamin K / Q000627:therapeutic use
D000970:Antineoplastic Agents; D003561:Cytarabine; D014812:Vitamin K; D014750:Vincristine; D004317:Doxorubicin; D011239:Prednisolone