title: Comparison of Chinese and Western rifapentines and improvement of bioavailability by prior taking of various meals.
abstract: Bioavailability was measured by rifapentine (RPE) serum concentrations and by the urinary ratio between RPE and creatinine, in specimens obtained 4-50 h after 600 mg RPE preceded by food. The bioavailabilities of RPEs manufactured in China and by a Western manufacturer were similar after a standard English breakfast, and serum concentrations were also similar to those obtained in an earlier Italian study following a complex meal. Although absorption of RPE was unsatisfactory after lipid-rich biscuits or shortbread, absorption after egges and toast was excellent and was nearly as good after a fast-food sandwich. The urinary measure of bioavailability at 26 h appeared as efficient as peak serum estimations at 6, 8 and 26 h. Fast-food sandwiches are being taken before RPE in a current clinical trial of Chinese RPE in Hong Kong.
authors.affiliation: Hong Kong Department of Health, Chest Services Central Office, Wanchai Polyclinic, Hong Kong, China.
authors.forename: S L
authors.initials: SL
authors.lastname: Chan
authors.forename: W W
authors.initials: WW
authors.lastname: Yew
authors.forename: J H
authors.initials: JH
authors.lastname: Porter
authors.forename: K P
authors.initials: KP
authors.lastname: McAdam
authors.forename: B W
authors.initials: BW
authors.lastname: Allen
authors.forename: J M
authors.initials: JM
authors.lastname: Dickinson
authors.forename: G A
authors.initials: GA
authors.lastname: Ellard
authors.forename: D A
authors.initials: DA
authors.lastname: Mitchison