title: Determination of serum fPLI concentrations in cats with diabetes mellitus.
abstract: Diabetes mellitus (DM) is one of the most common feline endocrinopathies. Pancreatitis is a reported cause for poor control of DM in cats; however, its prevalence in diabetic cats is unknown. Measurement of serum feline pancreatic lipase immunoreactivity (fPLI) has been proposed as a sensitive and specific test for the detection of pancreatitis in cats. The aim of this study was to assess fPLI concentrations in diabetic cats and compare these with non-diabetic cats of similar age. Samples from 29 cats with DM and 23 non-diabetic cats were analysed. Serum fPLI concentrations were significantly higher in samples from diabetic cats (P<0.01). A weak association was found between serum fructosamine and fPLI concentrations (R(2)=0.355, P=0.015), but there was no association between fPLI concentrations and the degree of diabetic control. There were no significant differences in reported clinical signs between cats with or without DM regardless of serum fPLI concentration. This is the first study to demonstrate elevated serum fPLI concentrations in cats with DM, suggesting that pancreatitis could be a significant comorbidity in these cats.
authors.affiliation: Department of Veterinary Clinical Science, University of Liverpool, Leahurst, UK. y.forcada@liverpool.ac.uk
authors.forename: Yaiza
authors.initials: Y
authors.lastname: Forcada
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: German
authors.forename: Peter J M
authors.initials: PJ
authors.lastname: Noble
authors.forename: Joerg M
authors.initials: JM
authors.lastname: Steiner
authors.forename: Jan S
authors.initials: JS
authors.lastname: Suchodolski
authors.forename: Peter
authors.initials: P
authors.lastname: Graham
authors.forename: Laura
authors.initials: L
authors.lastname: Blackwood
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002371:Cat Diseases / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D002415:Cats; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology / Q000662:veterinary*; D005260:Female; D019270:Fructosamine / Q000097:blood; D008049:Lipase / Q000097:blood*; D008297:Male; D010179:Pancreas / Q000201:enzymology*; D010195:Pancreatitis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D019270:Fructosamine; D008049:Lipase