title: Reduced habituation of trigeminal reflexes in patients with episodic cluster headache during cluster period.
abstract: A growing body of evidence supports the pivotal role of the hypothalamus in the pathophysiology of cluster headache (CH). On the basis of animal studies, it has been suggested that a hypothalamic dysfunction can lead to a habituation deficit of brainstem reflex responses, as result of a stress-like condition. Taking into account these findings, we tested the hypothesis that habituation of brainstem reflexes may be impaired in CH patients. The habituation phenomenon of the late components (R2 and R3) of the blink reflex was studied in 27 CH patients during the cluster period, in 22 migraine patients interictally and in 20 control subjects. A significant habituation deficit in the R2 and R3 components was found in CH compared with both controls and migraineurs. The lack of habituation in CH, more pronounced than in migraine, points to abnormal processing of sensory stimuli at the trigeminal level that could be driven by hypothalamic dysfunction during the cluster period.
authors.affiliation: University Centre for Adaptive Disorders and Headache, IRCCS 'C. Mondino Institute of Neurology' Foundation, University of Pavia, Pavia, Italy. armando.perrotta@mondino.it
authors.forename: A
authors.initials: A
authors.lastname: Perrotta
authors.forename: M
authors.initials: M
authors.lastname: Serrao
authors.forename: G
authors.initials: G
authors.lastname: Sandrini
authors.forename: D
authors.initials: D
authors.lastname: Bogdanova
authors.forename: C
authors.initials: C
authors.lastname: Tassorelli
authors.forename: M
authors.initials: M
authors.lastname: Bartolo
authors.forename: G
authors.initials: G
authors.lastname: Coppola
authors.forename: F
authors.initials: F
authors.lastname: Pierelli
authors.forename: G
authors.initials: G
authors.lastname: Nappi
mesh_terms: D000328:Adult; D000368:Aged; D001767:Blinking / Q000502:physiology*; D003027:Cluster Headache / Q000503:physiopathology*; D004292:Dominance, Cerebral; D004558:Electric Stimulation; D004576:Electromyography; D005154:Facial Nerve / Q000503:physiopathology; D005260:Female; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020326:Migraine without Aura / Q000503:physiopathology; D012021:Reflex, Abnormal / Q000502:physiology*; D014276:Trigeminal Nerve / Q000503:physiopathology*