title: Retinal peripapillary nerve fiber layer thickness in neuromyelitis optica.
abstract: OBJECTIVE
  To measure the thickness of retinal peripapillary nerve fibers throughout the course of neuromyelitis optica (NMO).
  
  
  METHODS
  This study was of a cross-sectional design, examining the thickness of the retinal peripapillary nerve fiber layer by optical coherence tomography, in patients with NMO (n = 15; 30 eyes), patients with multiple sclerosis (MS; n = 15; 30 eyes), and a control group (n = 23; 46 eyes). The thicknesses were acquired according to protocol with the fast RNFL (Retinal Nerve Fiber Layer) procedure. The study of visual function includes for each eye a determination of refraction, measurement of visual acuity, measurement of contrast vision, an analysis of color vision, and a frequency-doubling technology perimetry (FDTP). The main outcome measurements were the thickness of the retinal peripapillary nerve fibers, visual acuity, and scores of contrast vision.
  
  
  RESULTS
  The average thickness of retinal peripapillary nerve fibers was respectively in the NMO, MS, and control group: 65.44 +/- 24.19, 83.85 +/- 24.12, and 106.24 +/- 12.46 microm (P = 0.01). The average thickness of retinal peripapillary nerve fibers correlated to visual acuity, the scores of contrast vision, the scores of FDTP, and the number of episodes per patient (r = -0.58, P = 0.03).
  
  
  CONCLUSIONS
  This is the first study to produce measurements of the thickness of retinal peripapillary nerve fibers during optic neuropathies of NMO. The optic neuropathies of NMO are also accompanied by an acute and chronic axonal loss, as clearly illustrated by the OCT.
authors.affiliation: Services d'Ophtalmologie, Centre Hospitalier Universitaire de Fort de France, Hôpital Pierre Zobda-Quitman, Fort de France, Martinique, French West Indies. harold.merle@chu-fortdefrance.fr
authors.forename: Harold
authors.initials: H
authors.lastname: Merle
authors.forename: Stéphane
authors.initials: S
authors.lastname: Olindo
authors.forename: Angélique
authors.initials: A
authors.lastname: Donnio
authors.forename: Raymond
authors.initials: R
authors.lastname: Richer
authors.forename: Didier
authors.initials: D
authors.lastname: Smadja
authors.forename: Philippe
authors.initials: P
authors.lastname: Cabre
mesh_terms: D000328:Adult; D003118:Color Perception / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D009471:Neuromyelitis Optica / Q000503:physiopathology*; D009898:Optic Disk; D012029:Refraction, Ocular / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests