Adriamycin induced pulseless electrical activity and cardiovascular collapse during general anesthesia for ventriculo-peritoneal shunt insertion. A case report.
We report a case of a 45-year-old female undergoing an emergency ventriculoperitoneal shunt surgery. The patient had brain metastatic lesions of breast carcinoma with associated hydrocephalus. She had received Adriamycin as a part of chemotherapy regimen for breast cancer. Her preoperative cardiovascular status was normal. Under general anesthesia, the patient had a sudden cardiovascular collapse. The patient had a pulseless electrical activity and required inotropic support for cardiovascular stability. The possible cause is discussed.
Chander
Bala
B
Department of Neuroanaesthesiology, All India Institute of Medical Sciences, New Delhi, India.
Bhagat
Hemant
H
Prabhakar
Hemanshu
H
D000768:Anesthesia, General; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000150:complications / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D004317:Doxorubicin / Q000009:adverse effects*; D004569:Electroencephalography; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000601:surgery; D007431:Intraoperative Complications / Q000139:chemically induced* / Q000503:physiopathology* / Q000628:therapy; D008875:Middle Aged; D011674:Pulse; D012769:Shock / Q000139:chemically induced* / Q000503:physiopathology* / Q000628:therapy; D017287:Ventriculoperitoneal Shunt
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin