2,6-Diazaspiro[3.3]heptanes: synthesis and application in Pd-catalyzed aryl amination reactions.
A concise and scalable synthesis of a 2,6-diazaspiro[3.3]heptane building block is reported. The usefulness of this structural surrogate of piperazine is shown in arene amination reactions yielding a variety of N-Boc- N'-aryl-2,6-diazaspiro[3.3]heptanes.
Burkhard
Johannes
J
Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland.
Carreira
Erick M
EM
D000586:Amination; D001384:Azetidines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D001384:Azetidines; D010879:Piperazines; D013141:Spiro Compounds; D000077489:Piperazine; D010165:Palladium