Ergosta-4,6,8(14),22-tetraen-3-one from Vietnamese Xylaria sp. possessing inhibitory activity of nitric oxide production.
From the methanolic extract of Xylaria sp. collected in Vietnam, a fluorescent constituent, ergosta-4,6,8(14),22-tetraen-3-one (1) was isolated and elucidated by the combination of 2D NMR, high resolution MS, IR and UV spectroscopy. Its inhibitory activity of nitric oxide production in RAW 264.7 cells stimulated by lipopolysaccharide was examined and showed a potential activity with the IC(50) value of 28.96 microM.
Quang
Dang Ngoc
DN
Faculty of Chemistry, Hanoi University of Education, Hanoi, Vietnam. quangdn@hnue.edu.vn
Bach
Dang Dinh
DD
D000818:Animals; D002460:Cell Line; D002783:Cholestenones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D009569:Nitric Oxide / Q000096:biosynthesis*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014744:Vietnam; D013098:Xylariales / Q000737:chemistry*
D002783:Cholestenones; D008070:Lipopolysaccharides; D009569:Nitric Oxide; C015860:ergosta-4,6,8(14),22-tetraen-3-one