title: Maturation of rod function in preterm infants with and without retinopathy of prematurity.
abstract: OBJECTIVE
  To establish normal development of rod electroretinograms in preterm infants and to assess the effects of retinopathy of prematurity (ROP).
  
  
  METHODS
  We measured 88 Naka-Rushton functions from 41 preterm infants at maturities from 30 to 72 weeks postmenstrual age (PMA). Outcomes (log sigma, retinal sensitivity and V(max), retinal responsivity) were compared between control (no ROP), untreated ROP, and treated ROP.
  
  
  RESULTS
  In control infants, sensitivity increased by 1.5 log units from 30 to 40 weeks PMA and by a further 0.5 log units by 50 weeks PMA but was 0.5 log units less than in similarly-mature, healthy, term-born infants. Average retinal responsivity increased from 23 microV to 90 microV between 30 and 40 weeks PMA and was 35 muV greater at 40 weeks PMA than in similarly-mature term-born infants. At around 36 weeks PMA, (when onset of ROP peaks), infants with untreated ROP had average retinal sensitivity 0.2 log units lower than control infants; sensitivity was reduced further in infants treated for ROP. Retinal responsiveness did not differ between control subjects and untreated infants with ROP but was greatly reduced in infants treated for ROP.
  
  
  CONCLUSIONS
  Maturation of rod sensitivity appears to be slowed by preterm birth whereas maturation of rod responsivity is accelerated. ROP reduces retinal sensitivity, and treated ROP reduces both sensitivity and responsivity.
authors.affiliation: Department of Clinical Physics, Royal Hospital for Sick Children, and Princess Royal Maternity, Glasgow, United Kingdom.
authors.forename: Ruth
authors.initials: R
authors.lastname: Hamilton
authors.forename: Michael S
authors.initials: MS
authors.lastname: Bradnam
authors.forename: John
authors.initials: J
authors.lastname: Dudgeon
authors.forename: Helen
authors.initials: H
authors.lastname: Mactier
mesh_terms: D016022:Case-Control Studies; D004596:Electroretinography / Q000379:methods; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D053685:Laser Therapy; D008028:Light Coagulation; D012160:Retina / Q000503:physiopathology; D012164:Retinal Diseases / Q000175:diagnosis / Q000503:physiopathology; D015861:Retinal Neovascularization; D017948:Retinal Rod Photoreceptor Cells / Q000502:physiology / Q000503:physiopathology*; D012178:Retinopathy of Prematurity / Q000175:diagnosis* / Q000503:physiopathology*; D016896:Treatment Outcome