title: Lung transplantation at Duke University Medical Center.
abstract: Lung transplantation has undergone remarkable changes in clinical practice to address the higher rate of rejection and mortality. Our protocols include increased immunosuppression and strategies to address non-alloimmune injury, including GER. New and innovative approaches to lung transplantation are still needed to improve short- and long-term outcomes. The LAS implementation has had a strong influence on the type of native disease transplanted at our center as well as our waiting list time. However, the LAS was not predictive of survival posttransplant at one year. Further refinements of the LAS and protocols may improve survival posttransplant.
authors.affiliation: Division of Pulmonary and Critical Care, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Laurie D
authors.initials: LD
authors.lastname: Snyder
authors.forename: Ashley
authors.initials: A
authors.lastname: Finlen-Copeland
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Hartwig
authors.forename: Shu S
authors.initials: SS
authors.lastname: Lin
authors.forename: R Duane
authors.initials: RD
authors.lastname: Davis
authors.forename: Scott M
authors.initials: SM
authors.lastname: Palmer
mesh_terms: D000328:Adult; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy / Q000401:mortality; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016040:Lung Transplantation / Q000401:mortality* / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009657:North Carolina / Q000453:epidemiology; D011183:Postoperative Complications / Q000401:mortality; D012307:Risk Factors; D016019:Survival Analysis; D009927:Tissue and Organ Procurement / Q000706:statistics & numerical data; D014850:Waiting Lists
chemical_list: D007166:Immunosuppressive Agents