title: Hepatocellular carcinoma: management of an increasingly common problem.
abstract: Hepatocellular carcinoma (HCC) is a common cancer that typically occurs in the setting of cirrhosis and chronic hepatitis virus infections. Hepatitis B and C account for approximately 80% of cases worldwide. HCC is currently the fifth most common malignancy in men and the eighth in women worldwide; its incidence is increasing dramatically in many parts of the world. Recognition of those at risk and early diagnosis by surveillance with imaging, with or without serologic testing, are extremely important. Many highly effective and even curative therapies are now available and include resection, liver transplantation, and local ablation. Appropriate application of these interventions offers hope of prolonged survival to many patients with this otherwise lethal complication of liver disease.
authors.affiliation: Division of Hepatology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, USA. garydav@BaylorHealth.edu
authors.forename: Gary L
authors.initials: GL
authors.lastname: Davis
authors.forename: Jane
authors.initials: J
authors.lastname: Dempster
authors.forename: James D
authors.initials: JD
authors.lastname: Meler
authors.forename: Douglas W
authors.initials: DW
authors.lastname: Orr
authors.forename: Mark W
authors.initials: MW
authors.lastname: Walberg
authors.forename: Brian
authors.initials: B
authors.lastname: Brown
authors.forename: Brian D
authors.initials: BD
authors.lastname: Berger
authors.forename: John K
authors.initials: JK
authors.lastname: O'Connor
authors.forename: Robert M
authors.initials: RM
authors.lastname: Goldstein