[Geometrical analysis of protein-DNA interactions on the basis of the Voronoĭ-Delaune tessellation].
A new method for the rigorous analysis of DNA-protein contacts has been developed on the basis of Voronoi tessellation. This method permits one to determine close neighbors on the atomic level and compute the area of contact by edges of Voronoi polyhedra. Based on the results of the study of 1109 protein-DNA complexes from PDB, it was demonstrated that about one third of the contacts are the contacts with positively charged Arg and Lys. There is distinct amino acid prevalence for nucleotides: for A - Pro; for T - His; for G - Asp; for C - Trp, Asp, Glu. Therefore, GC pairs prefer to interact with negatively charged residues, and alanine and methionine, whereas AT pairs prefer to interact with histidine and unpolar residues.
Anashkina
A A
AA
Tumanian
V G
VG
Kuznetsov
E N
EN
Galkin
A V
AV
Esipova
N G
NG
D000596:Amino Acids / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D030562:Databases, Protein; D006860:Hydrogen Bonding; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D009711:Nucleotides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*
D000596:Amino Acids; D009711:Nucleotides; D011506:Proteins; D004247:DNA