In vitro interaction of terbinafine with itraconazole and amphotericin B against fungi causing chromoblastomycosis in China.
The combined effects of terbinafine with itraconazole and amphotericin B against Cladophialophora carrionii, Phialophora verrucosa and Fonsecaea pedrosoi were evaluated in vitro by the checker-board method and expressed as a fractional inhibitory concentration (FIC) index. Synergy was observed with the combination of terbinafine and itraconazole against one isolate of C. carrionii and no antagonism was observed. When amphotericin B was combined with terbinafine or itraconazole, no synergy or antagonism was noted with all isolates included in this investigation.
Yu
Jin
J
Department of Dermatology, Peking University First Hospital, Beijing, China.
Li
Ruoyu
R
Zhang
Min
M
Liu
Li
L
Wan
Zhe
Z
D000666:Amphotericin B / Q000494:pharmacology*; D000704:Analysis of Variance; D000935:Antifungal Agents / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects*; D002681:China; D002862:Chromoblastomycosis / Q000382:microbiology*; D004347:Drug Interactions; D006801:Humans; D066298:In Vitro Techniques; D017964:Itraconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000494:pharmacology*; D010676:Phialophora / Q000187:drug effects; D000077291:Terbinafine
D000935:Antifungal Agents; D009281:Naphthalenes; D017964:Itraconazole; D000666:Amphotericin B; D000077291:Terbinafine