title: Safe administration of an inactivated virosomal adjuvanted influenza vaccine in asthmatic children with egg allergy.
abstract: In order to evaluate whether the virosomal adjuvanted influenza vaccine that has been shown to have the lowest egg protein content (Inflexal V, Berna Biotech) could be administered to children with even severe egg allergy without any risk of allergic reactions, we used epicutaneous skin testing with the undiluted vaccine in 88 asthmatic children (44 with and 44 without egg allergy), none of whom had a positive response. They were then vaccinated with the whole dose of Inflexal V intramuscularly in a one-dose protocol, and the occurrence of any immediate or delayed adverse events were actively monitored for 28 days. The results showed the safety of the administration, and demonstrated that Inflexal V can be safely given without performing a vaccine skin test in children with any kind of egg allergy.
authors.affiliation: Institute of Pediatrics, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Commenda 9, 20122 Milan, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Esposito
authors.forename: Chiara
authors.initials: C
authors.lastname: Gasparini
authors.forename: Alberto
authors.initials: A
authors.lastname: Martelli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Zenga
authors.forename: Elena
authors.initials: E
authors.lastname: Tremolati
authors.forename: Elena
authors.initials: E
authors.lastname: Varin
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Marseglia
authors.forename: Alessandro
authors.initials: A
authors.lastname: Fiocchi
authors.forename: Nicola
authors.initials: N
authors.lastname: Principi
mesh_terms: D001249:Asthma / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D021181:Egg Hypersensitivity / Q000276:immunology*; D005260:Female; D006801:Humans; D007252:Influenza Vaccines / Q000009:adverse effects* / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D011446:Prospective Studies; D012882:Skin Tests; D022721:Vaccines, Virosome / Q000009:adverse effects* / Q000276:immunology*
chemical_list: C475022:Inflexal V; D007252:Influenza Vaccines; D022721:Vaccines, Virosome