Association of serum apolipoprotein B48 level with the presence of carotid plaque in type 2 diabetes mellitus.
OBJECTIVE
The atherogenicity of chylomicron remnants has been discussed. We examined whether serum apoB48 level is associated with the presence of carotid plaque in type 2 diabetic patients.


METHODS
Forty type 2 diabetic patients (21 males and 19 females, 52.8+/-11.8 years old; mean+/-S.D.) were divided into two groups by the presence or absence of carotid plaque. The diurnal change of serum apoB48 level was measured by enzyme-linked immunosorbent assay.


RESULTS
Fasting serum apoB48 level was higher in the subjects with carotid plaque than those without (6.5+/-3.8vs. 4.1+/-1.9 microg/ml, p=0.01). Age- and gender-adjusted analysis showed that the presence of carotid plaque was associated with fasting apoB48 (OR 1.43; 95% CI, 1.07-2.09, p=0.04) and triglyceride (OR 1.14; 95% CI, 1.02-1.32, p=0.04) levels. In normal LDL-cholesterol (<140 mg/dl) subjects, the presence of carotid plaque was associated with fasting apoB48 level (OR 2.16; 95% CI, 1.22-5.32, p=0.04), but not associated with fasting triglyceride level (OR 1.11; 95% CI, 0.99-1.30, p=0.13).


CONCLUSIONS
Serum apoB48 level was strongly associated with the presence of carotid plaque in type 2 diabetic patients.
Tanimura
Kyoko
K
Department of Medicine, Division of Endocrinology and Metabolism, Nippon Medical School, Tokyo, Japan.
Nakajima
Yasushi
Y
Nagao
Mototugu
M
Ishizaki
Akira
A
Kano
Toshiko
T
Harada
Taro
T
Okajima
Fumitaka
F
Sudo
Mariko
M
Tamura
Hideki
H
Ishii
Shinya
S
Sugihara
Hitoshi
H
Yamashita
Shizuya
S
Asai
Akira
A
Oikawa
Shinichi
S
D000328:Adult; D000368:Aged; D053283:Apolipoprotein B-48 / Q000097:blood*; D001794:Blood Pressure; D016893:Carotid Stenosis / Q000097:blood* / Q000503:physiopathology; D002940:Circadian Rhythm; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications* / Q000188:drug therapy; D003925:Diabetic Angiopathies / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D053283:Apolipoprotein B-48; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D014280:Triglycerides