title: High prevalence of allergic diseases and sensitization in a low allergen country.
abstract: BACKGROUND
  The prevalence of adult atopic diseases in Iceland is lower than in other West European countries, despite an affluent lifestyle, but limited data are available on children. The main aim of this study was to investigate the prevalence of atopic diseases and sensitivity to common allergens in 10- to 11-year-old Icelandic schoolchildren as part of phase II of the International Study of Asthma and Allergies in Children (ISAAC).
  
  
  METHODS
  Nine hundred and forty-six children and their parents answered a questionnaire about atopic diseases. Skin prick tests with six allergens were performed on 773 children and they were examined for signs of atopic dermatitis (AD).
  
  
  RESULTS
  The 12-month prevalence of allergic rhinoconjunctivitis and asthma was 11.5% and 8.9% respectively. The reported prevalence of AD was 27%, but only 9.2% had signs when inspected. A positive skin prick test (SPT) was found in 24.4% of the children, that is 18.8% to grass, 12.9% to cat, 3.6% to trees, 3.0% to Dermatophagoides pteronyssinus, 1.4% to D. farinae and 0.5% to Alternaria.
  
  
  CONCLUSIONS
  The high prevalence of atopic diseases in children at 10-11 years is surprising, as the prevalence in adults is low in Iceland. The findings resemble those in developing countries. Iceland has had an affluent lifestyle for a considerable time, but the absence of dust mites, low pet ownership and relatively low pollen counts in the country raise doubts about the role of exposure levels in the development of sensitization and atopic diseases.
authors.affiliation: Children's Hospital Iceland, Landspitali-University Hospital, Reykjavik, Iceland. mc@landspitali.is
authors.forename: Michael
authors.initials: M
authors.lastname: Clausen
authors.forename: Sigurdur
authors.initials: S
authors.lastname: Kristjansson
authors.forename: Asgeir
authors.initials: A
authors.lastname: Haraldsson
authors.forename: Bengt
authors.initials: B
authors.lastname: Björkstén
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects; D000485:Allergens / Q000276:immunology*; D000818:Animals; D000829:Animals, Domestic; D002648:Child; D003430:Cross-Sectional Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D007055:Iceland / Q000453:epidemiology; D007114:Immunization; D015995:Prevalence; D012307:Risk Factors; D012882:Skin Tests; D011795:Surveys and Questionnaires; D014028:Tobacco Smoke Pollution / Q000009:adverse effects
chemical_list: D000485:Allergens; D014028:Tobacco Smoke Pollution