Esophageal granular cell tumor covered by intramucosal squamous cell carcinoma: report of a case.
We report a case of a granular cell tumor (GCT) covered by squamous cell carcinoma (SCC) in the esophagus. A 69-year-old Japanese man was admitted to our hospital for treatment of superficial esophageal cancer detected by upper gastrointestinal endoscopy. Endoscopic examination revealed a shallow ulcer in the esophagus, 28-32 cm from the incisor teeth. The pathological findings of a biopsy of the lesion were moderately differentiated SCC. Thus, we performed partial esophagectomy with two-field (thoraco-abdominal) lymph node dissection. Microscopic examination of the surgical specimen revealed intraepithelial SCC with minimal invasion, and a GCT, 3 x 1 mm in size, in the submucosa just beneath the SCC. Cytoplasmic granules in the GCT were positive for periodic acid-Schiff. Immunohistochemically, the GCT was strongly positive for S-100 protein. To our knowledge, this is the first published report of a GCT covered by SCC in the esophagus.
Saito
Kana
K
Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Kato
Hiroyuki
H
Fukai
Yasuyuki
Y
Kimura
Hitoshi
H
Miyazaki
Tatsuya
T
Kashiwabara
Kenji
K
Nakajima
Takashi
T
Kuwano
Hiroyuki
H
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D016099:Endoscopy, Gastrointestinal; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery; D016586:Granular Cell Tumor / Q000473:pathology* / Q000601:surgery; D006801:Humans; D033162:Incidental Findings; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery