Epigenetic control in pituitary tumors.
Epigenetically-mediated gene dysregulation is a common feature associated with human pituitary tumorigenesis. The mechanisms leading to these changes, however, remain largely unknown. In this review, we examine changes responsible for DNA and histone modifications as independent, butpotentially interrlated modes of communication effecting chromatin remodeling. The dynamic properties of the enzymes involved in these reactions is highlighted. We use the fibroblast growth factor receptor 2 (FGFR2) as a model through which the p53-regulating melanoma-associated antigen (MAGE) system is governing in pituitary cells. The pathogenetic and potential therapeutic implications are discussed.
Ezzat
Shereen
S
Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics / Q000502:physiology; D019175:DNA Methylation / Q000502:physiology; D044127:Epigenesis, Genetic / Q000502:physiology*; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D006657:Histones / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010911:Pituitary Neoplasms / Q000235:genetics*; D011499:Protein Processing, Post-Translational / Q000502:physiology; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics / Q000502:physiology
D000951:Antigens, Neoplasm; D006657:Histones; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors