title: Broad-spectrum beta-lactam antibiotics with beta-lactamase inhibitors.
abstract: Combining cefoperazone, piperacillin or ticarcillin with the beta-lactamase inhibitors sulbactam, tazobactam or clavulanic acid, respectively, results in compounds with activity against a wide range of Gram-positive and Gram-negative aerobic and anaerobic organisms, including strains producing beta-lactamases. Pharmacokinetics of the three combinations are similar. Cefoperazone/sulbactam can be given twice daily as opposed to a minimum of three-times-daily dosing required with the other combinations. All 9 combinations have a good safety profile, and may be administered parenterally for the treatment of severe infections in hospitalized patients, including intra-abdominal, gynaecological, skin and soft tissue infections. Additional cover may be provided by administering one of these combinations with an aminoglycoside.
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario 'Gregorio Mararañón', Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Muñoz
authors.forename: F
authors.initials: F
authors.lastname: García-Garrote
authors.forename: E
authors.initials: E
authors.lastname: Bouza