title: Resolution of syringomyelia and Chiari malformation after growth hormone therapy.
abstract: BACKGROUND
  The association between hypopituitarism, Chiari I malformation, and syringomyelia has been recently recognized. Most of the reported patients suffered perinatal injury or asphyxia.
  
  
  METHODS
  We present the case of a premature child without identifiable perinatal injury, who was recognized to have growth hormone (GH) deficiency, Chiari I malformation, and syringohydromyelia.
  
  
  CONCLUSIONS
  There was a resolution of syrinx and tonsillar herniation after GH replacement.
authors.affiliation: Division of Pediatric Neurosurgery, Department of Pediatric Surgery, British Columbia Children's Hospital/Children's and Women's Health Centre, 4480 Oak St, #K3-159, Vancouver, BC, Canada.
authors.forename: Ashok
authors.initials: A
authors.lastname: Gupta
authors.forename: Aleksander M
authors.initials: AM
authors.lastname: Vitali
authors.forename: Ralph
authors.initials: R
authors.lastname: Rothstein
authors.forename: D Douglas
authors.initials: DD
authors.lastname: Cochrane
mesh_terms: D001139:Arnold-Chiari Malformation / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D002648:Child; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008279:Magnetic Resonance Imaging; D008297:Male; D013595:Syringomyelia / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D019382:Human Growth Hormone; D013974:Thyroxine