title: Direct comparison between pharmacological stress with adenosine triphosphate disodium and exercise stress myocardial perfusion imagings.
abstract: To clarify the significance of adenosine triphosphate disodium stress myocardial perfusion imaging (ATP-MPI), we directly compared the findings of ATP-MPI with those of exercise stress myocardial perfusion imaging (Ex-MPI). ATP-MPI, Ex-MPI, and coronary angiography (CAG) were performed within 60 days in 17 coronary artery disease patients with mean age of 62.1+/-7.9 years. CAG revealed single-vessel disease (SVD) in 10 patients and multivessel disease (MVD) in seven patients. The summed stress score (SSS) of ATP-MPI was significantly higher than that of Ex-MPI (10.0 [7.8-14.3] vs. 8.0 [4-18], P<0.05). No difference in the SSS was observed between ATP-MPI and Ex-MPI in patients with SVD (8.0 [6.0-9.0] vs. 8.0 [6.0-10.0], NS), whereas this difference was significant in patients with MVD (15.0 [14.0-22.8] vs.9 [7.3-16.3], P<0.05). There was no difference in the summed rest score between ATP-MPI and Ex-MPI. The univariate logistic analysis showed that "MVD" was the significant factor influencing to the overt discrepancy between ATP-MPI and Ex-MPI (odds ratio: 9.0, 95% confidence interval: 1.07-75.84, P=0.043). The accuracy of ATP-MPI and Ex-MPI in detecting the territory of stenotic coronary vessel or previous myocardial infarction was 98.0% and 92.1% (NS), respectively. In conclusion, ATP-MPI is useful for detecting potential ischemic areas that cannot be detected by Ex-MPI, particularly in patients with MVD.
authors.affiliation: Department of Medicine, Nippon Medical School, Chiba-Hokusou Hospital, Chiba, Japan.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Ohba
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Takano
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kunimi
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Fujita
authors.forename: Eitaro
authors.initials: E
authors.lastname: Kodani
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Mizuno
mesh_terms: D000255:Adenosine Triphosphate; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging
chemical_list: D000255:Adenosine Triphosphate