Self-assembly of perfunctionalized beta-cyclodextrins on a quartz crystal microbalance for real-time chiral recognition.
This study reports the development of novel chiral sensors based on the self-assembly of perfunctionalized beta-cyclodextrins (beta-CD) on a quartz crystal microbalance transducer for real time chiral recognition. Ten chiral sensors immobilized with mercaptyl perfunctionalized beta-cyclodextrins were found to exhibit promising enantioselectivity in the gas phase. Well-defined sizes of molecular cavities of the modified beta-CDs associated with cooperative weak interactions with the host molecules afforded enhanced chiral discrimination. This study contributes to the realization of novel chiral sensors applicable for real-time recognition and analysis of enantiomeric alcohols and lactates.
Xu
Changhua
C
Department of Chemistry, National University of Singapore, Singapore.
Ng
Siu Choon
SC
Chan
Hardy Sze On
HS
D003460:Crystallization; D007773:Lactates / Q000737:chemistry; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D015394:Molecular Structure; D011791:Quartz; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013499:Surface Properties; D013997:Time Factors; D047392:beta-Cyclodextrins / Q000737:chemistry*
D007773:Lactates; D013438:Sulfhydryl Compounds; D047392:beta-Cyclodextrins; C028444:methyl lactate; D011791:Quartz