The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia.
OBJECTIVE
Host genetic factors implicated in AIDS dementia complex (ADC) were studied.


METHODS
DNA from ADC patients (n=56), unselected HIV-seropositive patients (n=112, 171, 185 and 204) and HIV-seronegative controls (n=204, 60, 60, 96 and 624) were typed for polymorphic loci in genes encoding tumour necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-12 and Apolipoprotein E (ApoE). Diagnosis of ADC was based on neurological symptoms, signs and neuroimaging findings with other causes of dementia excluded. Patients selected had ADC stage > or =1 and CD4 counts of <500 cells/microL.


RESULTS
Allele 2 of TNFA-308 was more common in ADC patients compared to HIV-positive or HIV-negative controls (P=0.005, 0.024). No other differences between ADC patients and control groups were significant. Meta-analyses confirmed these results.


CONCLUSIONS
This study suggests that TNFA-308 allele 2 or an allele in linkage disequilibrium with this locus influences ADC.
Pemberton
L A
LA
Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia. l.pemberton@cfi.unsw.edu.au
Stone
E
E
Price
P
P
van Bockxmeer
F
F
Brew
B J
BJ
D015526:AIDS Dementia Complex / Q000235:genetics* / Q000276:immunology; D000293:Adolescent; D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D015967:Gene Expression Regulation, Viral; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics; D015810:Linkage Disequilibrium; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012306:Risk; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D055815:Young Adult
D001057:Apolipoproteins E; D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha