[Effect of yupingfengsan on the growth of tumor and immunological function in tumor-bearing mice].
OBJECTIVE
To explore the effect of yupingfengsan on the growth of tumor and immunological function in tumor-bearing mice.


METHODS
The models of tumor-bearing mice were established by inoculating the healthy mice with S180 tumor carneus cells cultured in vitro. Then the ratio of tumor restriction was calculated. The phagocytosis activity of phagocytes, the level of NO secreted by phagocytes, the proliferating activity of T lymphocytes and the level of IL-2 were detected in the mice after being treated with yupingfengsan 12 days.


RESULTS
yupingfengsan elevated the phagocytosis of phagocytes and the level of NO secreted by phagocytes. It promoted T lymphocytes to transform, and increased the level of IL-2 and the activity of NK cells.


CONCLUSIONS
yupingfengsan can increase the immunological function of tumor-bearing mice and suppress the development of tumor in mice.
Zhang
Hong-Jun
HJ
Department of Pathogenic Biology, Mudanjiang Medical College, Mudanjiang 157011, China. zhanghj33@yahoo.com.cn
Tang
Xiao-Yun
XY
Ju
Bao-Ling
BL
Song
Bao-Hui
BH
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D007376:Interleukin-2 / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009589:Nitrogen Oxides / Q000378:metabolism; D010586:Phagocytes / Q000187:drug effects / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D009589:Nitrogen Oxides