title: The impact of prehospital transport interval on survival in out-of-hospital cardiac arrest: implications for regionalization of post-resuscitation care.
abstract: OBJECTIVE
  There is growing evidence that therapeutic hypothermia and other post-resuscitation care improves outcomes in out-of-hospital cardiac arrest (OHCA). Thus, transporting patients with return of spontaneous circulation (ROSC) to specialized facilities may increase survival rates. However, it is unknown whether prolonging transport to reach a designated facility would be detrimental.
  
  
  METHODS
  Data from OHCA patients treated in EMS systems that cover approximately 70% of Arizona's population were evaluated (October 2004-December 2006). We analyzed the association between transport interval (depart scene to ED arrival) and survival to hospital discharge in adult, non-traumatic OHCA patients and in the subgroup who achieved ROSC and remained comatose.
  
  
  RESULTS
  1846 OHCA occurred prior to EMS arrival. Complete transport interval data were available for 1177 (63.8%) patients (study group). 253 patients (21.5%) achieved ROSC and remained comatose making them theoretically eligible for transport to specialized care. Overall, 70 patients (5.9%) survived and 43 (17.0%) comatose ROSC patients survived. Mean transport interval for the study group was 6.9 min (95% CI: 6.7, 7.1). Logistic regression revealed factors that were independently associated with survival: witnessed arrest, bystander CPR, method of CPR, initial rhythm of ventricular fibrillation, and shorter EMS response time interval. There was no significant association between transport interval and outcome in either the overall study group (OR=1.2; 0.77, 1.8) or in the comatose, ROSC subgroup (OR 0.94; 0.51, 1.8).
  
  
  CONCLUSIONS
  Survival was not significantly impacted by transport interval. This suggests that a modest increase in transport interval from bypassing the closest hospital en route to specialized care is safe and warrants further investigation.
authors.affiliation: Arizona Resuscitation Research Institute, Department of Emergency Medicine, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA. dan@aemrc.arizona.edu
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Spaite
authors.forename: Ben J
authors.initials: BJ
authors.lastname: Bobrow
authors.forename: Tyler F
authors.initials: TF
authors.lastname: Vadeboncoeur
authors.forename: Vatsal
authors.initials: V
authors.lastname: Chikani
authors.forename: Lani
authors.initials: L
authors.lastname: Clark
authors.forename: Terry
authors.initials: T
authors.lastname: Mullins
authors.forename: Arthur B
authors.initials: AB
authors.lastname: Sanders
mesh_terms: D000368:Aged; D001130:Arizona / Q000453:epidemiology; D004632:Emergency Medical Services / Q000458:organization & administration*; D005260:Female; D006323:Heart Arrest / Q000401:mortality*; D006801:Humans; D016015:Logistic Models; D008297:Male; D011446:Prospective Studies; D012041:Regional Medical Programs / Q000458:organization & administration*; D015996:Survival Rate; D013997:Time Factors; D014187:Transportation of Patients