title: Testing the level of response to alcohol-based model of heavy drinking and alcohol problems in offspring from the San Diego Prospective Study.
abstract: OBJECTIVE
  The low level of response (LR) to alcohol, an endophenotype related to heavy drinking and alcohol problems, influences the risk for alcoholism in the context of additional life domains. This article evaluates an LR-based model of drinking patterns in 113 drinking offspring, ages 12 to 24 years, from the San Diego Prospective Study.
  
  
  METHODS
  Correlations and structural equation models (SEMs) were evaluated using LR as measured from the Self-Report of the Effects of Alcohol questionnaire in the offspring. The expectations of the effects of alcohol (EXPECT), the perception of drinking in peers (PEER), the use of alcohol to cope with stress (COPE), and the drinking quantities and alcohol-related problems (ALCOUT) were evaluated in the SEM.
  
  
  RESULTS
  The LR-based model worked well, with good fit characteristics and 78% of the variance of outcome explained. LR related directly to ALCOUT, with additional mediation of that relationship through EXPECT and COPE.
  
  
  CONCLUSIONS
  The LR-based model performed well in adolescents from the San Diego Prospective Study. Knowledge of which domains mediate how LR impacts alcohol-related outcomes may be useful in developing more focused and potentially more effective prevention approaches.
authors.affiliation: Department of Psychiatry (116A), University of California, San Diego, California, USA. mschuckit@ucsd.edu
authors.forename: Marc A
authors.initials: MA
authors.lastname: Schuckit
authors.forename: Tom L
authors.initials: TL
authors.lastname: Smith
authors.forename: Ryan
authors.initials: R
authors.lastname: Trim
authors.forename: Sara
authors.initials: S
authors.lastname: Kreikebaum
authors.forename: Briana
authors.initials: B
authors.lastname: Hinga
authors.forename: Rhonda
authors.initials: R
authors.lastname: Allen
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000235:genetics / Q000517:prevention & control / Q000523:psychology; D000435:Alcoholic Intoxication / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D000437:Alcoholism / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control; D002140:California; D002648:Child; D016241:Child of Impaired Parents; D003469:Culture; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007600:Judgment; D008297:Male; D008960:Models, Psychological; D010379:Peer Group; D010641:Phenotype; D011446:Prospective Studies; D018570:Risk Assessment; D013315:Stress, Psychological / Q000150:complications