Rab5 and rac team up in cell motility.
Cell motility requires actin assembly mediated by Rac, a Rho family GTPase. In this issue, Palamidessi et al. (2008) show that Rab5-directed trafficking of Rac to the cell membrane is required for Rac-mediated actin assembly. Trafficking of Rac may influence the mode of cell migration during morphogenesis and cancer metastasis.
Zech
Tobias
T
The Beatson Institute for Cancer Research, Glasgow G61 1BD, UK.
Machesky
Laura
L
D000818:Animals; D002465:Cell Movement; D048430:Cell Shape; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009024:Morphogenesis; D009362:Neoplasm Metastasis; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D020696:rab5 GTP-Binding Proteins / Q000378:metabolism*
D017228:Hepatocyte Growth Factor; D051057:Proto-Oncogene Proteins c-akt; D020696:rab5 GTP-Binding Proteins