title: 5-Alpha reductase inhibitors in men with an enlarged prostate: an evaluation of outcomes and therapeutic alternatives.
abstract: This article presents background information and highlights key findings from a managed care perspective related to enlarged prostate (EP) in Medicare-eligible patients. This article does not provide a comprehensive review of EP but instead attempts to increase the current understanding of EP through discussion of its prevalence in men aged > or =65 years, its associated economic burden, and some available treatment options. This supplement includes 3 additional articles, all of which present data from a naturalistic, managed care setting. The article by Fenter et al assesses differences in outcomes between elderly EP patients treated with finasteride and those treated with dutasteride in relation to the risks of acute urinary retention and prostate-related surgery. Issa et al conduct a comparative analysis of the combined use of alpha-blockers and 5-alpha reductase inhibitors to treat EP. The final article compares medical costs incurred within the first year of initiating treatment for EP patients receiving finasteride versus dutasteride. This supplement is intended to assist managed care formulary decision makers in evaluating key clinical and economic data that differentiate dutasteride and finasteride within the Medicare-aged population. Although the information presented is not designed to illustrate the superiority of one product over the other, it answers important questions in relation to treating EP in elderly men and raises substantial issues beyond medication costs.
authors.affiliation: University of Maryland School of Medicine, Baltimore, MD, USA. mnaslund@smail.umaryland.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Naslund
authors.forename: Timothy S
authors.initials: TS
authors.lastname: Regan
authors.forename: Christine
authors.initials: C
authors.lastname: Ong
authors.forename: Susan L
authors.initials: SL
authors.lastname: Hogue
mesh_terms: D058891:5-alpha Reductase Inhibitors; D000368:Aged; D000369:Aged, 80 and over; D001378:Azasteroids / Q000627:therapeutic use; D000068538:Dutasteride; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D018120:Finasteride / Q000627:therapeutic use; D006801:Humans; D008297:Male; D006278:Medicare / Q000191:economics; D011470:Prostatic Hyperplasia / Q000188:drug therapy* / Q000191:economics / Q000201:enzymology; D016896:Treatment Outcome; D014481:United States; D016055:Urinary Retention / Q000209:etiology* / Q000628:therapy
chemical_list: D058891:5-alpha Reductase Inhibitors; D001378:Azasteroids; D004791:Enzyme Inhibitors; D018120:Finasteride; D000068538:Dutasteride