New MCR-Heck-isomerization cascade toward indoles.
The use of ortho-iodonitrophenol in Ugi-Smiles reaction coupled with Heck cyclization gives new access to indole scaffolds. The sequence can be performed in a one-pot reaction if the residual isocyanide is neutralized prior to the addition of the palladium catalyst.
El Kaim
Laurent
L
Laboratoire Chimie et Procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris Cedex 15, France. laurent.elkaim@ensta.fr
Gizzi
Marion
M
Grimaud
Laurence
L
D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D009596:Nitrophenols / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism
D007211:Indoles; D009570:Nitriles; D009596:Nitrophenols; D010165:Palladium