title: Primary mantle-cell non-Hodgkin's lymphoma of the tongue.
abstract: The evaluation of tongue swellings often represents a diagnostic challenge, because of the wide spectrum of benign and malignant possible lesions. We report a case of a patient presenting a tongue mass. An incisional biopsy was performed. Diagnosis of primary Mantle Cell non-Hodgkin's Lymphoma of the tongue was made by histological, immunohistochemical and cytogenetic studies. Our patient was treated with Rituximab-Cyclophosphamide, Epirubicine, Vincristine, Prednisone polychemotherapy plus Rituximab as single agent maintenance. Complete remission was achieved and no relapse has occurred during a follow-up of 53 months. We emphasize the importance of including also NHL in differential diagnosis of a tongue mass.
authors.affiliation: Department of Haematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Naples, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Guastafierro
authors.affiliation: Department of Haematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Naples, Italy. umberto80@libero.it.|, Via Unità Italiana 52, 81100, Caserta, Italy. umberto80@libero.it.
authors.forename: Umberto
authors.initials: U
authors.lastname: Falcone
authors.affiliation: Department of Haematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Naples, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Celentano
authors.affiliation: Department of Radiology, Second University of Naples, Naples, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cappabianca
authors.affiliation: Department of Head and Neck Surgery, Second University of Naples, Naples, Italy.
authors.forename: Amerigo
authors.initials: A
authors.lastname: Giudice
authors.affiliation: Department of Head and Neck Surgery, Second University of Naples, Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Colella
mesh_terms: D005260:Female; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D014059:Tongue / Q000473:pathology*; D014062:Tongue Neoplasms / Q000473:pathology*