title: Clinicopathologic findings of colorectal traditional and sessile serrated adenomas in Korea: a multicenter study.
abstract: OBJECTIVE
  Serrated polyps have emerged as important evidence supporting the serrated polyp-neoplasia pathway in colorectal carcinogenesis, an alternate to the classical adenoma-carcinoma sequence. However, there is confusion over the diagnostic criteria for serrated polyps including traditional serrated adenoma (TSA) and sessile serrated adenoma (SSA). In addition, clinical and pathologic characteristics of each are largely unknown and need further exploration.
  
  
  METHODS
  The 753 polyps that were previously diagnosed as serrated adenoma (SA) from 14 tertiary care university hospitals in Korea between 2003 and 2005 were evaluated for the clinicopathologic findings of TSA and SSA.
  
  
  RESULTS
  Among 753 cases, 420 (55.8%) were reclassified as TSA and 56 (7.4%) as SSA. Among the pathologic parameters, crypt branching, crypt dilatation, and horizontal crypts were more frequent in SSA than in TSA (p < 0.001). SSA was larger than TSA (12.6 +/- 7.3 vs. 9.8 +/- 6.9 mm, p = 0.005), was more likely to be flat type (p = 0.006), and was more frequently located in the proximal colorectum (p = 0.012). There were no significant differences in age, sex, and body mass index between TSA and SSA.
  
  
  CONCLUSIONS
  Locationand endoscopic features of the polyps with abnormal crypt morphology in histologic findings could be helpful for the diagnosis and classification of SAs.
authors.affiliation: Yonsei University College of Medicine, Institute of Gastroenterology, Seoul, Korea.
authors.forename: Sang Kil
authors.initials: SK
authors.lastname: Lee
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Chang
authors.forename: Tae Il
authors.initials: TI
authors.lastname: Kim
authors.forename: Won Ho
authors.initials: WH
authors.lastname: Kim
authors.forename: Cheol Keun
authors.initials: CK
authors.lastname: Park
authors.forename: Dong Kyung
authors.initials: DK
authors.lastname: Chang
authors.forename: Dong Il
authors.initials: DI
authors.lastname: Park
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Sohn
authors.forename: Jeong-Sik
authors.initials: JS
authors.lastname: Byeon
authors.forename: Suk-Kyun
authors.initials: SK
authors.lastname: Yang
authors.forename: Jin Oh
authors.initials: JO
authors.lastname: Kim
authors.forename: Suk-Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: So Young
authors.initials: SY
authors.lastname: Jin
authors.forename: Cheol Hee
authors.initials: CH
authors.lastname: Park
authors.forename: Il Hyun
authors.initials: IH
authors.lastname: Baek
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Eun
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Han
authors.forename: Seun Ja
authors.initials: SJ
authors.lastname: Park
authors.forename: Hee Kyung
authors.initials: HK
authors.lastname: Chang
authors.forename: Yoon Tae
authors.initials: YT
authors.lastname: Jeen
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Park
authors.forename: Sung Jae
authors.initials: SJ
authors.lastname: Shin
authors.forename: Mee Soo
authors.initials: MS
authors.lastname: Chang
mesh_terms: D000236:Adenoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity