title: Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells.
abstract: Pregabalin and gabapentin are lipophilic amino acid derivatives of gamma-amino butyric acid that show anticonvulsant and analgesic activity against neuropathic pain. In this study, we investigated their actions on substance P-induced NF-kappaB activation in human neuroblastoma and rat glioma cells. Pregabalin and gabapentin decreased substance P-induced NF-kappaB activation in these cells. These drugs also inhibited NF-kappaB activation in rat spinal dorsal root ganglia cells pre-treated in vitro with substance P. These results suggest a previously undefined role of pregabalin and gabapentin in the regulation of inflammation-related intracellular signaling in both neuronal and glial cells.
authors.affiliation: Dongduk Women's University, Department of Applied Chemistry, Seoul, Korea. sypark21@dongduk.ac.kr
authors.forename: Seyeon
authors.initials: S
authors.lastname: Park
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Ahn
authors.forename: Dong Woo
authors.initials: DW
authors.lastname: Han
authors.forename: Jong Hwa
authors.initials: JH
authors.lastname: Lee
authors.forename: Kyung Tae
authors.initials: KT
authors.lastname: Min
authors.forename: Hyunkyung
authors.initials: H
authors.lastname: Kim
authors.forename: Yong-Woo
authors.initials: YW
authors.lastname: Hong
mesh_terms: D000588:Amines / Q000494:pharmacology*; D000818:Animals; D045744:Cell Line, Tumor; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D000077206:Gabapentin; D005727:Ganglia, Spinal / Q000473:pathology; D005910:Glioma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009447:Neuroblastoma / Q000378:metabolism / Q000473:pathology*; D000069583:Pregabalin; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D013373:Substance P / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D016328:NF-kappa B; D013373:Substance P; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin