Glomerular filtration: the charge debate charges ahead.
The concept that the glomerular filtration barrier exhibits charge selectivity is a basic tenet of renal physiology. Heparan sulfate is a major contributor of glomerular anionic charge. In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.
Miner
Jeffrey H
JH
Renal Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
D000818:Animals; D005919:Glomerular Filtration Rate; D006497:Heparan Sulfate / Q000096:biosynthesis / Q000737:chemistry* / Q000502:physiology; D006801:Humans; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics; D050199:Podocytes / Q000378:metabolism; D011507:Proteinuria / Q000209:etiology; D055672:Static Electricity; D000099058:Exostosin 1
D006497:Heparan Sulfate; D017351:N-Acetylglucosaminyltransferases; D000099058:Exostosin 1