No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry.
Single nucleotide polymorphisms (SNPs) in the trace amine associated receptor trace amine associated receptor 6 gene and 3' flanking region have been shown to be associated with schizophrenia. To replicate these findings, we conducted a family-based association study with the five most significant SNPs in our sample of 79 sib-pair families (56/79 sib-pair families showed linkage to 6q23) and 125 triads. No evidence for association was obtained between these SNPs and schizophrenia in our sample, even when limited to the 56 linked families (P>0.2). We conclude that trace amine associated receptor 6 is not important for the development of schizophrenia in our family samples.
Ludewick
Herbert P
HP
Western Australian Institute of Medical Research and Centre for Medical Research, University of Western Australia, School of Psychiatry and Clinical Neuroscience, Nedlands, WA 6009, Australia.
Schwab
Sibylle G
SG
Albus
Margot
M
Lerer
Bernard
B
Maier
Wolfgang
W
Trixler
Matyas
M
Wildenauer
Dieter B
DB
D018797:Cell Cycle Proteins / Q000235:genetics*; D005190:Family; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D044465:White People / Q000235:genetics*; D000095383:Trace Amine-Associated Receptors
D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D043562:Receptors, G-Protein-Coupled; C493988:TAAR6 protein, human; D000095383:Trace Amine-Associated Receptors