title: Dietary omega-3 fats for treatment of inflammatory joint disease: efficacy and utility.
abstract: There is high level evidence (meta-analysis of randomized, controlled trials) for symptomatic benefits from fish oil use in rheumatoid arthritis, and there is biologic plausibility for its clinical effects. Fish oil also has safety advantages in reducing cardiovascular risk via direct cardiovascular effects and via nonsteroidal anti-inflammatory drug-sparing. This is an important aspect of fish oil use, given the increased cardiovascular risk in rheumatoid arthritis. Perceived barriers to clinical use are readily addressed.
authors.affiliation: Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia.
authors.forename: Susanna M
authors.initials: SM
authors.lastname: Proudman
authors.forename: Leslie G
authors.initials: LG
authors.lastname: Cleland
authors.forename: Michael J
authors.initials: MJ
authors.lastname: James
mesh_terms: D001172:Arthritis, Rheumatoid / Q000178:diet therapy / Q000188:drug therapy* / Q000378:metabolism; D004041:Dietary Fats / Q000493:pharmacokinetics; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000178:diet therapy / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic
chemical_list: D004041:Dietary Fats; D015525:Fatty Acids, Omega-3