title: Antidiabetic effect of an active fraction extracted from dragon's blood (Dracaena Cochinchinensis).
abstract: The active fraction extracted from dragon's blood displayed an inhibitory effect on alpha-glucosidase activity with an IC50 of 0.152 microg/mL, which is nearly half of the crude material. Its inhibition on alpha-glucosidase was noncompetitive. In addition, when this fraction was orally administered to mice dosed with Acarbose (20 mg/kg), the active fraction (100, 300, 500 mg/kg) significantly suppressed increase of blood glucose levels after sucrose loading in a dose-dependent manner. These results suggest that this extract from dragon's blood exerts an anti-diabetic effect by suppressing intestinal carbohydrate absorption and thereby reducing the postprandial increase of blood glucose.
authors.affiliation: School of Life Sciences, Shanghai University, Shanghai, China.
authors.forename: Hui-Juan
authors.initials: HJ
authors.lastname: Gu
authors.forename: Jing-Ci
authors.initials: JC
authors.lastname: Lv
authors.forename: Ke-Lan
authors.initials: KL
authors.lastname: Yong
authors.forename: Xu
authors.initials: X
authors.lastname: Chen
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Liu
authors.forename: Xia-Bing
authors.initials: XB
authors.lastname: Zhang
mesh_terms: D020909:Acarbose; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D050260:Carbohydrate Metabolism / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D031409:Dracaena / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000302:isolation & purification*; D007408:Intestinal Absorption; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D020909:Acarbose