title: The role of carotid plaque vulnerability and inflammation in the pathogenesis of acute ischemic stroke.
abstract: BACKGROUND
  Increasing evidences show that disruption of carotid plaque followed by arterio-arterial thromboembolism is an important mechanism in the generation of ischemic stroke. Inflammatory mechanisms play a key role in transforming structurally vulnerable plaques into functionally unstable ones. The purpose of the present study is to evaluate the roles of carotid plaque vulnerability and inflammation in the pathogenesis of acute ischemic stroke.
  
  
  METHODS
  Fifty-two patients with acute ischemic stroke affecting the anterior circulation (stroke group) and 44 with asymptomatic carotid stenosis (asymptomatic group) were investigated. Duplex ultrasonography was used to evaluate the characteristics of carotid plaque and grading the degree of carotid stenosis. Plaque echogenicity was assessed as echolucent, predominantly echolucent, predominantly echogenic, or echogenic. Plaque surface was classified as smooth, irregular, or ulcerated. All subjects had duplex-determined 50% to 99% carotid stenosis. Serum levels of matrix metalloproteinase-9 (MMP-9), tissue inhibitors of metalloproteinases (TIMP-1), soluble CD40 ligand (sCD40L) and high-sensitivity C-reactive protein (hsCRP) were measured.
  
  
  RESULTS
  Plaques in the stroke group were echolucent or predominantly echolucent, whereas those of the asymptomatic group were predominantly echogenic or echogenic plaques (P<0.05). Irregular and ulcerated plaques were frequently found in stroke patients, while smooth plaques were frequently detected in asymptomatic patients (P<0.05). Serum levels of MMP-9, sCD40L, hsCRP were higher in stroke than in asymptomatic patients. By contrast, serum TIMP-1 levels were significantly higher in the asymptomatic than in the stroke group.
  
  
  CONCLUSIONS
  The results suggest that inflammation plays a crucial role in carotid plaque vulnerability and, together with carotid plaque morphology, in the pathogenesis of acute ischemic stroke.
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China.
authors.forename: Shifang
authors.initials: S
authors.lastname: Ding
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Zhao
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Chen
authors.forename: Guihua
authors.initials: G
authors.lastname: Yao
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.forename: Pengfei
authors.initials: P
authors.lastname: Zhang
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000208:Acute Disease; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000473:pathology*; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000473:pathology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D003430:Cross-Sectional Studies; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D014463:Ultrasonography