title: Anti-inflammatory activity of indanyltetrazole derivatives.
abstract: A number of indanyl tetrazolederivatives namely 5-(6'-chloroindan-1'-yl)tetrazole (CIT), 5-(6'-bromoindan-1'-yl)tetrazole (BIT), 5-(6'-chloroindan-1'-yl)methyltetrazole (CIMT), 5-(6'-bromoindan-1'-yl)methyl-tetrazole (BIMT) were evaluated for the anti-inflammatory activity in carragennan induced rat paw edema in Swiss albino Wister rats for 24-hour period at the dose of 100 mg/kg of body weight by intraperitoneal route where phenylbutazone (PBZ) was used as the standard. All of these compounds exhibited inhibition on rat paw edema with peak actions observed following 3 hours after administration. Moreover, compounds CIMT and BIMT were further evaluated at dose of 50 mg/kg of body weight. Among the compounds, CIMT showed higher activity than others and was very close to standard phenylbutazone.
authors.affiliation: Department of Pharmacy, East West University, Mohakhali, Dhaka, Bangladesh.
authors.forename: Sukumar
authors.initials: S
authors.lastname: Bepary
authors.forename: Biplab K
authors.initials: BK
authors.lastname: Das
authors.forename: Sitesh C
authors.initials: SC
authors.lastname: Bachar
authors.forename: Joydev K
authors.initials: JK
authors.lastname: Kundu
authors.forename: Abu Shara
authors.initials: AS
authors.lastname: Shamsur Rouf
authors.forename: Bidyut K
authors.initials: BK
authors.lastname: Datta
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002351:Carrageenan; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D007189:Indans / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013777:Tetrazoles / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D007189:Indans; D013777:Tetrazoles; D002351:Carrageenan; D010653:Phenylbutazone