title: Apolipoprotein E (APOE) and lipoprotein lipase (LPL) gene variants and carotid atherosclerotic lesions in the oldest old: a population-based autopsy study.
abstract: We investigated the association between histologically defined atherosclerotic lesions in the carotid arteries and the genetic variants of APOE and LPL in a population-based sample of Finns aged 85 or over. Post-mortem analysis of carotid arteries was performed in 240 subjects. Atherosclerotic lesions were categorized according to the modified American Heart Association criteria, and classified into four different categories: pathological intimal thickening (PIT), fibrous cap atheromas (FCA), calcified lesions (CL), and atherosclerotic burden (AB) (a combination of the other three categories). APOE epsilon4 genetic variant was associated with PIT (p=0.018) and AB (p=0.006) in the carotid arteries, and its effect was independent of the serum lipid levels. The genetic variant LPL Ser447Ter was protective against FCA (p=0.031) and AB (p=0.012), while APOE epsilon2 was protective against FCA (p=0.035). Our results suggest that the APOE epsilon4, epsilon2 and LPL Ser447Ter variants may have different roles in the atherosclerotic process and their effects are seen even in the oldest old population.
authors.affiliation: Folkhälsan Institute of Genetics and Department of Pathology, University of Helsinki and Helsinki University Central Hospital, POB 63, 00014 Helsinki, Finland. liisa.myllykangas@helsinki.fi
authors.forename: Liisa
authors.initials: L
authors.lastname: Myllykangas
authors.forename: G Alistair
authors.initials: GA
authors.lastname: Lammie
authors.forename: Irma-Leena
authors.initials: IL
authors.lastname: Notkola
authors.forename: Raimo
authors.initials: R
authors.lastname: Sulkava
authors.forename: Tuomo
authors.initials: T
authors.lastname: Polvikoski
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics*; D001344:Autopsy; D002114:Calcinosis / Q000473:pathology; D002340:Carotid Artery Diseases / Q000235:genetics* / Q000473:pathology*; D005260:Female; D015870:Gene Expression; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D011159:Population Surveillance
chemical_list: D001057:Apolipoproteins E; D008071:Lipoprotein Lipase