title: Antimalarial, antimycobacterial and cytotoxic limonoids from Chisocheton siamensis.
abstract: Five limonoids isolated from the seeds of Chisocheton siamensis were tested for their antimalarial activity against Plasmodium falciparum, antimycobacterial activity against Mycobacterium tuberculosis and cytotoxic activity against NCI-H187 (human small cell lung cancer), KB (oral human epidermal carcinoma) and MCF-7 (breast cancer) cancer cell lines. All limonoids (1-5) showed inhibitory effect against Plasmodium falciparum with IC(50) values ranging from 2.06 to 6.31 microg/ml. Only azadiradione (2) exhibited strong inhibitory effect against Mycobacterium tuberculosis with the MIC of 6.25 microg/ml. Compounds 1-4 also showed cytotoxic activity against NCI-H187, KB and MCF-7 cancer cell lines and dysobinine (1) had the highest activity with IC(50) of 1.67, 3.17 and 2.15 microg/ml, respectively.
authors.affiliation: School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand.
authors.forename: W
authors.initials: W
authors.lastname: Maneerat
authors.forename: S
authors.initials: S
authors.lastname: Laphookhieo
authors.forename: S
authors.initials: S
authors.lastname: Koysomboon
authors.forename: K
authors.initials: K
authors.lastname: Chantrapromma
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D036701:Limonins / Q000302:isolation & purification / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D012639:Seeds / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D000970:Antineoplastic Agents; D036701:Limonins; D010936:Plant Extracts