title: Phosphate starvation signaling: a threesome controls systemic P(i) homeostasis.
abstract: Systemic signaling between roots and shoots is required to maintain mineral nutrient homeostasis for optimal metabolism under varying environmental conditions. Recent work has revealed molecular components of a signaling module that controls systemic phosphate homeostasis, modulates uptake and transport in Arabidopsis. This module comprises PHO2, a protein that controls protein stability, the phloem-mobile microRNA-399 and a ribo-regulator that squelches the activity of miR399 towards PHO2 by a novel mechanism. This advance is a significant step for the design of future rational approaches to improve crop phosphate use efficiency.
authors.affiliation: Institute of Molecular Plant Science, School of Biological Sciences, Daniel Rutherford Building, King's Buildings, University of Edinburgh, Edinburgh EH9 3JH, Scotland, United Kingdom. Peter.Doerner@ed.ac.uk
authors.forename: Peter
authors.initials: P
authors.lastname: Doerner
mesh_terms: D017360:Arabidopsis / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000502:physiology; D006706:Homeostasis; D035683:MicroRNAs / Q000502:physiology; D008954:Models, Biological; D010710:Phosphates / Q000378:metabolism*; D022661:RNA, Untranslated / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D044763:Ubiquitin-Conjugating Enzymes / Q000502:physiology
chemical_list: D029681:Arabidopsis Proteins; D035683:MicroRNAs; D010710:Phosphates; D022661:RNA, Untranslated; C514696:UBC24 protein, Arabidopsis; D044763:Ubiquitin-Conjugating Enzymes