Persistent pulmonary infection with an azole-resistant Coccidioides species.
We report a case of a life-threatening, recurrent, and azole-resistant pulmonary coccidioidomycosis in a patient receiving long-term fluconazole therapy for a history of coccidioidal meningitis. Since this diagnosis, the patient has received weekly amphotericin B for more than four years and remains in remission with a stable serum Coccidioides complement fixation antibody titer.
Kriesel
John D
JD
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA. john.kriesel@hsc.utah.edu
Sutton
Deanna A
DA
Schulman
Susan
S
Fothergill
Annette W
AW
Rinaldi
Michael G
MG
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001393:Azoles / Q000627:therapeutic use*; D003045:Coccidioides / Q000187:drug effects / Q000302:isolation & purification*; D003047:Coccidioidomycosis / Q000188:drug therapy / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D016921:Meningitis, Fungal / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D012008:Recurrence
D000935:Antifungal Agents; D001393:Azoles; D000666:Amphotericin B