Aging and animal models of systemic insult: trauma, burn, and sepsis.
In the acute-care setting, it is widely accepted that elderly patients have increased morbidity and mortality compared with young healthy patients. The reasons for this, however, are largely unknown. Although animal modeling has helped improve treatment strategies for young patients, there are a scarce number of studies attempting to understand the mechanisms of systemic insults such as trauma, burn, and sepsis in aged individuals. This review aims to highlight the relevance of using animals to study the pathogenesis of these insults in the aged and, despite the deficiency of information, to summarize what is currently known in this field.
Nomellini
Vanessa
V
The Burn and Shock Trauma Institute and the Immunology and Aging Program, Loyola University Medical Center, Maywood, Illinois 60153, USA.
Gomez
Christian R
CR
Gamelli
Richard L
RL
Kovacs
Elizabeth J
EJ
D000375:Aging / Q000473:pathology; D000818:Animals; D002056:Burns / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D018805:Sepsis / Q000473:pathology / Q000503:physiopathology*