title: No association between systemic sclerosis and C77G polymorphism in the human PTPRC (CD45) gene.
abstract: OBJECTIVE
  The functional variant C77G (rs17612648) of PTPRC (CD45) was described to confer risk for systemic sclerosis (SSc) in German Caucasians. We analyzed this association in an independent, larger German cohort.
  
  
  METHODS
  We genotyped 171 cases and 179 controls. Cases were subgrouped according to sex, autoantibody profiles, or clinical subsets.
  
  
  RESULTS
  No association of SSc with C77G was detected in the whole dataset, in subgroups, or in combined analyses with a previous study.
  
  
  CONCLUSIONS
  The results do not confirm PTPRC C77G as a general and independent risk factor for development of SSc.
authors.affiliation: Institute of Clinical Immunology and Transfusion Medicine,University of Leipzig, Leipzig, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Kirsten
authors.forename: Mechthild
authors.initials: M
authors.lastname: Blume
authors.forename: Frank
authors.initials: F
authors.lastname: Emmrich
authors.forename: Nico
authors.initials: N
authors.lastname: Hunzelmann
authors.forename: Rudolf
authors.initials: R
authors.lastname: Mierau
authors.forename: Rita
authors.initials: R
authors.lastname: Rzepka
authors.forename: Peter
authors.initials: P
authors.lastname: Vaith
authors.forename: Torsten
authors.initials: T
authors.lastname: Witte
authors.forename: Inga
authors.initials: I
authors.lastname: Melchers
authors.forename: Peter
authors.initials: P
authors.lastname: Ahnert
mesh_terms: D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005858:Germany; D006801:Humans; D017493:Leukocyte Common Antigens / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000097:blood / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human