Effect of IgG immunoadsorption on serum cytokines in MG and LEMS patients.
We investigated the effect of IgG immunoadsorption (IA) on cytokine network in patients with treatment-resistant Myasthenia Gravis (MG) and Lambert-Eaton Syndrome (LEMS). We observed upregulation of interleukin (IL)-10, an anti-inflammatory and B cells growth factor, and reduction of pro-inflammatory factors such as IL-18 and IL-17, in both MG and LEMS after IA. Our observation suggests that the massive removal of antibodies might induce modifications of the cytokine balance linked to T and B cells mediated autoimmunity.
Baggi
Fulvio
F
Neurology IV, Neurological Institute Foundation "Carlo Besta", Via Celoria 11, 20133 Milan, Italy. baggi@istituto-besta.it
Ubiali
Federica
F
Nava
Sara
S
Nessi
Valeria
V
Andreetta
Francesca
F
Rigamonti
Andrea
A
Maggi
Lorenzo
L
Mantegazza
Renato
R
Antozzi
Carlo
C
D000293:Adolescent; D000328:Adult; D020865:Calcium Channels, P-Type / Q000276:immunology; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007163:Immunosorbent Techniques; D015624:Lambert-Eaton Myasthenic Syndrome / Q000097:blood* / Q000276:immunology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood* / Q000276:immunology / Q000628:therapy*; D011863:Radioimmunoassay / Q000379:methods; D011950:Receptors, Cholinergic / Q000276:immunology
D020865:Calcium Channels, P-Type; D016207:Cytokines; D007074:Immunoglobulin G; D011950:Receptors, Cholinergic