title: The validity of complex breast cysts after surgery.
abstract: BACKGROUND
  Breast cysts are the most common cause of benign breast masses. Simple breast cysts do not need further evaluation, but complex breast cysts require additional assessment due to the potential presence of malignancy. However, these complex cysts have rarely been examined and quantified according to the associated cancer detection rate. Our study is the first investigation to evaluate the malignancy rate of complex breast cysts identified by histopathological results.
  
  
  METHODS
  Imaging findings of complex cysts were correlated retrospectively with clinical and pathologic outcomes. We detected a malignancy rate of 14%. Sonographic criteria of a complex cyst such as thick cyst wall (P = .0006), lobulation (P = .01), and hyperechogenicity (P = .04) were predictive of neoplasm. Two or more criteria combined were associated with a 13.6-fold higher risk of malignancy (P <.0001).
  
  
  CONCLUSIONS
  Based on our results we reinforce the importance of adequate assessment of complex breast cysts to prevent a missed or delayed diagnosis of malignancy.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Senology, Medical University of Vienna, Vienna, Austria. muy-kheng.tea@meduniwien.ac.at
authors.forename: Muy-Kheng M
authors.initials: MK
authors.lastname: Tea
authors.forename: Christoph
authors.initials: C
authors.lastname: Grimm
authors.forename: Anneliese
authors.initials: A
authors.lastname: Fink-Retter
authors.forename: Diana
authors.initials: D
authors.lastname: Bikas
authors.forename: Regina
authors.initials: R
authors.lastname: Kroiss
authors.forename: Ernst
authors.initials: E
authors.lastname: Kubista
authors.forename: Teresa
authors.initials: T
authors.lastname: Wagner
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D016217:Ultrasonography, Mammary