The binding of antibiotics to ERp57/GRP58.
The effects of five antibiotics, previously described as ligands of protein disulfide isomerase PDI, have now been studied on the homologous protein ERp57. They bind to this protein with much higher affinity than to PDI, and some of them inhibit the reductase and the DNA-binding activities of ERp57. In view of the high affinity of vancomycin, erythromycin and streptomycin, some effects of their interaction with this protein might be expected in vivo.
Gaucci
Elisa
E
Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Sapienza-Università di Roma, Italy.
Chichiarelli
Silvia
S
Grillo
Caterina
C
Vecchio
Emiliana Del
ED
Eufemi
Margherita
M
Turano
Carlo
C
D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D001665:Binding Sites; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D011485:Protein Binding; D019704:Protein Disulfide-Isomerases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism
D000900:Anti-Bacterial Agents; D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; D008024:Ligands; D011994:Recombinant Proteins; D004247:DNA; D019704:Protein Disulfide-Isomerases; C085868:PDIA3 protein, human