title: Successful thalamic deep brain stimulation for orthostatic tremor.
abstract: We report a patient with severe orthostatic tremor (OT) unresponsive to pharmacological treatments that was successfully controlled with thalamic (Vim, ventralis intermedius nucleus) deep brain stimulation (DBS) over a 4-year period. Cortical activity associated with the OT revealed by EEG back-averaging and fluoro-deoxi-glucose PET were also suppressed in parallel with tremor arrest. This case suggests that Vim-DBS may be a useful therapeutic approach for patients highly disabled by OT.
authors.affiliation: Department of Neurology, Neurophysiology and Neurosurgery, Clínica Universitaria, Universidad de Navarra, Pamplona, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Guridi
authors.forename: Maria C
authors.initials: MC
authors.lastname: Rodriguez-Oroz
authors.forename: Javier
authors.initials: J
authors.lastname: Arbizu
authors.forename: Manuel
authors.initials: M
authors.lastname: Alegre
authors.forename: Elena
authors.initials: E
authors.lastname: Prieto
authors.forename: Ignacio
authors.initials: I
authors.lastname: Landecho
authors.forename: Miguel
authors.initials: M
authors.lastname: Manrique
authors.forename: Julio
authors.initials: J
authors.lastname: Artieda
authors.forename: Jose A
authors.initials: JA
authors.lastname: Obeso
mesh_terms: D046690:Deep Brain Stimulation / Q000379:methods*; D004244:Dizziness / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013788:Thalamus / Q000502:physiology*; D014202:Tremor / Q000150:complications / Q000628:therapy*