[Dissociated learning with GABAergic drugs].
The possibility of dissociated learning was investigated using drugs which act directly on GABAB receptors of the brain. The earlier proposed suggestion that the cholinergic system plays a key role in the mechanisms of dissociated learning was tested. It was shown in male Wistar rats that dissociated learning was possible with GABAergic drugs. The dissociated state was induced by injecting the animals with both GABA agonist Baclofen and GABA antagonist 5-aminovaleric acid. Thus, dissociated learning is possible with drugs which act on either cholinergic or GABAergic transmitter systems.
Azarashvili
A A
AA
Kaĭmachnikova
I E
IE
D021542:Amino Acids, Neutral / Q000494:pharmacology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018080:Receptors, GABA-B / Q000502:physiology*
D021542:Amino Acids, Neutral; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D018080:Receptors, GABA-B; C013809:5-aminovaleric acid; D001418:Baclofen