title: The role of SLRP-proteoglycans in osteosarcoma pathogenesis.
abstract: The small leucine-rich repeat proteoglycans (SLRPs) constitute a group of structurally and functionally related molecules that participate in the organization of the extracellular matrix ECM and have important effects on cell behavior. Osteosarcomas are heterogeneous bone tumors whose common characteristic is the production of an abundant nonmineralized (ECM)-osteoid. The scope of this minireview is to briefly present the current state of knowledge on the role of the SLRPs in osteosarcoma pathogenesis, with special emphasis on the recently described in osteosarcoma, proteoglycan lumican.
authors.affiliation: Lab of Histology, Medical School, University of Crete, Heraklion, Greece.
authors.forename: Dragana
authors.initials: D
authors.lastname: Nikitovic
authors.forename: Katerina
authors.initials: K
authors.lastname: Berdiaki
authors.forename: Georgia
authors.initials: G
authors.lastname: Chalkiadaki
authors.forename: Nikos
authors.initials: N
authors.lastname: Karamanos
authors.forename: George
authors.initials: G
authors.lastname: Tzanakakis
mesh_terms: D000818:Animals; D058578:Biglycan; D002465:Cell Movement; D049109:Cell Proliferation; D011508:Chondroitin Sulfate Proteoglycans / Q000378:metabolism*; D058575:Decorin; D005109:Extracellular Matrix / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006801:Humans; D007632:Keratan Sulfate / Q000378:metabolism*; D000071234:Lumican; D012516:Osteosarcoma / Q000378:metabolism* / Q000473:pathology; D011509:Proteoglycans / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C546884:BGN protein, human; D058578:Biglycan; D011508:Chondroitin Sulfate Proteoglycans; C546878:DCN protein, human; D058575:Decorin; D016326:Extracellular Matrix Proteins; C000604306:LUM protein, human; D000071234:Lumican; D011509:Proteoglycans; D007632:Keratan Sulfate