title: [New developments in neuromuscular blocking agents].
abstract: Curare was clinically used in a patient with acute appendicitis by Griffith and Johnson in January 1942. From the day on, the development of new muscle relaxants went on in the world. Since pancuronium was synthesized by Savage in 1964, it was widely used in clinical cases because it provided sufficient muscle relaxation during operation. At present, pancuronium, vecuronium and rocuronium are routinely used in the world. In the future, we expect development of new muscle relaxants with rapid onset, intermediate duration of action, rapid recovery and without side effects.
authors.affiliation: Hokushin General Hospital, Nagano 383-8505.
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Otagiri
mesh_terms: D000732:Androstanols; D000818:Animals; D015195:Drug Design; D006801:Humans; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D010197:Pancuronium; D000077123:Rocuronium; D013390:Succinylcholine; D014673:Vecuronium Bromide
chemical_list: D000732:Androstanols; D009466:Neuromuscular Blocking Agents; D014673:Vecuronium Bromide; D013390:Succinylcholine; D010197:Pancuronium; D000077123:Rocuronium