title: Evaluation of gross tumor size using CT, 18F-FDG PET, integrated 18F-FDG PET/CT and pathological analysis in non-small cell lung cancer.
abstract: OBJECTIVE
  The correlation of gross tumor sizes between combined 18F-FDG PET/CT images and macroscopic surgical samples has not yet been studied in detail. In the present study, we compared CT, 18F-FDG PET and combined 18F-FDG PET/CT for the delineation of gross tumor volume (GTV) and validated the results through examination of the macroscopic surgical specimen.
  
  
  METHODS
  Fifty-two operable non-small cell lung cancer (NSCLC) patients had integrated 18F-FDG PET/CT scans preoperatively and pathological examination post-operation. Four separate maximal tumor sizes at X (lateral direction), Y (ventro-dorsal direction) and Z (cranio-caudal direction) axis were measured on 18F-FDG PET, CT, combined 18F-FDG PET/CT and surgical specimen, respectively. Linear regression was calculated for each of the three imaging measurements versus pathological measurement.
  
  
  RESULTS
  No significant differences were observed among the tumor sizes measured by three images and pathological method. Compared with pathological measurement, CT size at X, Y, Z axis was larger, whereas combined 18F-FDG PET/CT and 18F-FDG PET size were smaller. Combined 18F-FDG PET/CT size was more similar to the pathological size than that of 18F-FDG PET or CT. Results of linear regressions showed that integrated 18F-FDG PET/CT was the most accurate modality in measuring the size of cancer.
  
  
  CONCLUSIONS
  18F-FDG PET/CT correlates more faithfully with pathological findings than 18F-FDG PET or CT. Integrated 18F-FDG PET/CT is an effective tool to define the target of GTV in radiotherapy.
authors.affiliation: Department of Radiation Oncology, Qilu Hospital, Medical school, Shandong University, Jinan, Shandong Province 250012, China.
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Yu
authors.forename: Yun Fang
authors.initials: YF
authors.lastname: Liu
authors.forename: Ming
authors.initials: M
authors.lastname: Hou
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Xiao Nan
authors.initials: XN
authors.lastname: Li
authors.forename: Jin Ming
authors.initials: JM
authors.lastname: Yu
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D018511:Systems Integration; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18