Mast cell activation by myelin through scavenger receptor.
A role for mast cells (MC) in the pathogenesis of multiple sclerosis (MS) has been suggested, based on the analysis of human lesions and on an animal model of the disease (EAE). What role MC play in the development of MS is not well understood. We hypothesized that the link connecting MC with demyelinating diseases may be represented by their interaction with myelin. Here we show that myelin can activate mast cells. This process could be a key event in the mast cell function required for inducing EAE in mice and possibly in MS in man.
Medic
Nevenka
N
Department of Physiology and Pathology, University of Trieste, via A. Fleming 22, 34127 Trieste Italy.
Vita
Francesca
F
Abbate
Rita
R
Soranzo
Maria Rosa
MR
Pacor
Sabrina
S
Fabbretti
Elsa
E
Borelli
Violetta
V
Zabucchi
Giuliano
G
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology; D002478:Cells, Cultured; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008854:Microscopy, Electron / Q000379:methods; D009185:Myelin Proteins / Q000494:pharmacology; D009186:Myelin Sheath / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism / Q000648:ultrastructure; D009836:Oligodendroglia / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D051116:Receptors, Scavenger / Q000502:physiology*; D013481:Superoxides / Q000378:metabolism; D013997:Time Factors; D000267:Tissue Adhesions / Q000378:metabolism
D009185:Myelin Proteins; D051116:Receptors, Scavenger; D013481:Superoxides