Analgesic and antidiarrheal properties of Ocimum selloi essential oil in mice.
Ocimum selloi essential oil (2, 20, and 200 mg/kg; p.o.) reduced, in a dose-dependent way, the abdominal contraction induced by acetic acid (0.6%; i.p.) and the diarrhea episodes induced by castor oil in mice. At the higher dose (200 mg/kg; p.o.), the essential oil significantly reduced intestinal transit (P<0.05) in the charcoal meal test. The main component detected in O. selloi essential oil was methyl chavicol (98%; GC and GC/MS).These effects seems to support the use of O. selloi against diarrhea, intestinal spasm and visceral pain.
Franca
Carolina S
CS
Physiology Department (DFS), Federal University of Sergipe, São Cristovão, Sergipe, CEP 49.100-000, Brazil. carolinafranca18@yahoo.com.br
Menezes
Fábia S
FS
Costa
Larissa C B
LC
Niculau
Edenilson S
ES
Alves
Péricles B
PB
Pinto
José E B
JE
Marçal
Rosilene M
RM
D019342:Acetic Acid; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000930:Antidiarrheals / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005772:Gastrointestinal Transit / Q000187:drug effects; D008297:Male; D051379:Mice; D031339:Ocimum / Q000737:chemistry; D009822:Oils, Volatile / Q000302:isolation & purification / Q000627:therapeutic use*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010276:Parasympatholytics / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves; D013035:Spasm / Q000188:drug therapy
D000700:Analgesics; D000930:Antidiarrheals; D009822:Oils, Volatile; D010276:Parasympatholytics; D010936:Plant Extracts; D019342:Acetic Acid