[Effects of different Chinese herbal medicines on biochemical parameters in guinea-pig with pigment gallstones].
OBJECTIVE
To observe the effects of Qingdan Capsule (QDC) and Yanggan Lidan Granule (YGLDG), two kinds of compound traditional Chinese herbal medicines, on biochemical parameters in guinea-pigs with pigment gallstones.


METHODS
An animal model of pigment gallstones was established in male guinea-pigs by hypodermic injection of lincomycin. The guinea-pigs were randomly divided into blank control group, untreated group, QDC group and YGLDG group. There were 8 guinea-pigs in each group. After ten-day treatment, animals were sacrificed and sampled to calculate the rate of stone formation, total bilirubin (TB), unconjugated bilirubin (UCB) and Ca2+ density in bile of the four groups.


RESULTS
In comparison with the untreated group, the rates of stone formation in the QDC and YGLDG groups were significantly decreased (P<0.01). TBIL, UCB and Ca2+ content of bile in both QDC and YGLD groups was also significantly decreased (P<0.05, P<0.01).


CONCLUSIONS
QDC and YGLD have good effects on biochemical changes of animal model of pigment gallstone in reversing the lithogenesity of bile by reducing the content of TB, UCB and Ca2+, hence resulting in clinical treatment and prevention of pigment gallstone disease.
Zhang
Jing-zhe
JZ
Department of Hepatobiliary Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. zjzzzq@sina.com
Zhang
Xue-lin
XL
Liang
Xiao-qiang
XQ
Gu
Hong-gang
HG
Zhu
Pei-ting
PT
D000818:Animals; D001654:Bile Pigments / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D042882:Gallstones / Q000139:chemically induced / Q000737:chemistry* / Q000188:drug therapy*; D006168:Guinea Pigs; D008034:Lincomycin; D008297:Male; D008517:Phytotherapy; D011897:Random Allocation
D001654:Bile Pigments; D002756:Cholagogues and Choleretics; D004365:Drugs, Chinese Herbal; D008034:Lincomycin; D002118:Calcium