Suppression of male courtship by a Drosophila pheromone receptor.
In male Drosophila, chemosensory cues control many aspects of social behavior. We found that males with a mutated Gustatory receptor 32a gene (Gr32a) show high courtship toward males and mated females, indicating that GR32a functions as a pheromone receptor for a male inhibitory pheromone. Notably, we discovered that tarsal Gr32a-expressing neurons were essential for courtship suppression and projected to the ventrolateral protocerebrum, implying direct communication of chemosensory neurons with a higher-order brain structure.
Miyamoto
Tetsuya
T
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Amrein
Hubert
H
D000818:Animals; D030801:Animals, Genetically Modified; D003380:Courtship; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D005121:Extremities / Q000294:innervation; D005260:Female; D018390:Gene Targeting; D007266:Inhibition, Psychological; D008297:Male; D009474:Neurons / Q000502:physiology; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology*; D043563:Receptors, Pheromone / Q000235:genetics / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000502:physiology*; D014741:Video Recording
D029721:Drosophila Proteins; C531466:Gr32a protein, Drosophila; D011956:Receptors, Cell Surface; D043563:Receptors, Pheromone