title: Decreased expression of annexin A1 during the progression of cervical neoplasia.
abstract: The aim of this study was to evaluate whether the expression of annexin A1 (ANXA1) is associated with the progression of cervical neoplasia. ANXA1 expression was examined by immunohistochemistry in paraffin-embedded cervical tissue samples (n = 234), comprising 52 samples of normal cervical epithelia, 30 of cervical intraepithelial neoplasia (CIN) I, 27 of CIN II, 32 of CIN III, and 93 of invasive squamous cell carcinoma (ISCC). ANXA1 expression was strong in normal cervical squamous epithelium and significantly reduced with increasing progression of cervical neoplasia. Moreover, a close association was observed between ANXA1 expression and tumour cell differentiation in ISCC. These preliminary results indicate that ANXA1 may be an effective candidate for detecting CIN lesions and for evaluating tumour cell differentiation in squamous cell carcinoma of the cervix.
authors.affiliation: Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: L D
authors.initials: LD
authors.lastname: Wang
authors.forename: Y H
authors.initials: YH
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: H T
authors.initials: HT
authors.lastname: Song
authors.forename: L Y
authors.initials: LY
authors.lastname: Zhang
authors.forename: P L
authors.initials: PL
authors.lastname: Li
mesh_terms: D000818:Animals; D017305:Annexin A1 / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D002584:Cervix Uteri / Q000166:cytology / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000378:metabolism / Q000473:pathology
chemical_list: D017305:Annexin A1