Serum inflammatory biomarkers in Parkinson's disease.
Numerous recent findings indicate the involvement of a neuroinflammatory reaction in the neurodegeneration in idiopathic Parkinson's disease (PD). We examined 29 consecutive patients with PD, ages 54-84 years, most of whom were moderately impaired (median UPDRS 19; Hoehn-Yahr 3; MMSE 28). A series of serum biomarkers were investigated, and their levels were correlated with the degree of the motor and cognitive impairment. There were no abnormalities of IL-6, acute phase proteins (C-reactive protein, serum amyloid A, alpha 1-antitrypsin, orosomucoid, ceruloplasmin, alpha 2-macroglobulin, transferrin, prealbumin) and factors of the complement system (C1q, C1-INH, C3, C4). A decrease in Mannan-binding lectin (MBL) levels was observed in six patients; an elevation of tumor necrosis factor-alpha (TNF-alpha) was found in 12 patients. No statistically significant correlation was found between the patient's clinical state (neuropsychologic and motor, as expressed by UPDRS III, Hoehn-Yahr, and MMSE) and the immunomarker changes. Our results indicate that the inflammatory process may be reflected in the serum; nevertheless, further research is needed to elucidate the possible clinical implications.
Dufek
M
M
1st Department of Neurology, Masaryk University, St. Anne's University Hospital, Pekarska 53, 65691 Brno, Czech Republic. michal.dufek@fnusa.cz
Hamanová
M
M
Lokaj
J
J
Goldemund
D
D
Rektorová
I
I
Michálková
Z
Z
Sheardová
K
K
Rektor
I
I
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000097:blood / Q000150:complications; D011569:Psychiatric Status Rating Scales; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D015415:Biomarkers; D037601:Mannose-Binding Lectin; D014409:Tumor Necrosis Factor-alpha