title: [CD20 antigen of Hodgkin and Reed-Sternberg cells as possible prognostic factor in patients with Hodgkin's lymphoma--preliminary reports].
abstract: THE AIM of the study was to asses the validity of CD20 expression on H-RS cells as independent prognostic factor in patients with Hodgkin's lymphoma.
  
  
  METHODS
  72 patients (44 men and 28 women) between 15 and 73 y.o. (av. 36,5 y.o) treated in the Department of Oncological Chemotherapy of Silesian Medical Academy (1992-2002) were included in the study. Tissue specimens were immunohistochemically stained with monoclonal antibodies for CD20.
  
  
  RESULTS
  Analyzed group was classified according to histological subtype as follows: LP - n = 3, NS - n = 26, MC - n = 23, LR - n = 7 and LD - n = 13. Overall survival (OS) for the group was from 3 to 169 months (av. 64,5), disease free survival (DFS) - 4 to 167 months (av. 44,8) respectively. CD20 expression on H-RS cells was found in 13,9% subjects. Statistically significant difference (p = 0,0001) in DFS has been found between groups with and without CD20 expression. Results of this study are preliminary and should be confirmed in larger prospective studies.
authors.affiliation: Klinika Chorób Wewnetrznych i Chemioterapii Onkologicznej Slaskiej Akademii Medycznej w Katowicach.
authors.forename: Barbara
authors.initials: B
authors.lastname: Rygoł
authors.forename: Sławomira
authors.initials: S
authors.lastname: Krzemień
authors.forename: Jacek
authors.initials: J
authors.lastname: Pajak
authors.forename: Piotr
authors.initials: P
authors.lastname: Konicki
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Kowal
authors.forename: Wojciech
authors.initials: W
authors.lastname: Spychałowicz
authors.forename: Joanna
authors.initials: J
authors.lastname: Mykała-Cieśla
authors.forename: Teresa
authors.initials: T
authors.lastname: Gasińska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Krajewski-Siuda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D018951:Antigens, CD20 / Q000096:biosynthesis*; D005260:Female; D015870:Gene Expression; D006689:Hodgkin Disease / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016539:Reed-Sternberg Cells / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D018951:Antigens, CD20