[Chronic imipramine treatment normalizes decreased sexual motivation and high predisposition to catalepsy induced by propylthiouracil in rat].
Thyroxine synthesis inhibitors produced augmentation in predisposition to catalepsy and a decrease of sexual motivation and acoustic startle reflex response in rat. Sensitivity of these behavioral alterations to antidepressants was unknown. Chronic treatment with prototypical antidepressant imipramine (15 mg/kg, 21 days) prevented manifestation of catalepsy expression and sexual motivation reduction in Wistar rats given propylthiouracil (50 mg/l, 28 days) but did not influence startle reflex amplitude. Behavioral recovery induced by imipramine did not attribute to alterations in locomotor activity in open-field test or body weight gain. 5-HT(2A)-receptor mRNA level in the frontal cortex was not changed either. Model of sexual motivation disturbance and catalepsy induced by propylthiouracil in rat seems to be prospective to study the role of thyroid dysfunctions in mechanisms of depression and antidepressant treatment.
Tikhonova
M A
MA
Amstislavskaia
T G
TG
Kulikov
A V
AV
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D013956:Antithyroid Agents; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D002540:Cerebral Cortex / Q000378:metabolism; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D011441:Propylthiouracil; D051381:Rats; D017208:Rats, Wistar; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced / Q000188:drug therapy*
D000929:Antidepressive Agents, Tricyclic; D013956:Antithyroid Agents; D044402:Receptor, Serotonin, 5-HT2A; D011441:Propylthiouracil; D007099:Imipramine