Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat.
OBJECTIVE
Stable gastric pentadecapeptide BPC 157 accelerates the healing of a transected Achilles tendon and a transected quadriceps muscle. It may also be of clinical relevance as a systemic and local peptide treatment for crush injury of a major muscle, such as gastrocnemius muscle complex. BPC 157 is effective without a carrier, and it is presently undergoing trials for inflammatory bowel disease, and no toxicity has so far been reported.


METHODS
In crushed rats (force delivered 0.727 Ns/cm2), BPC 157 was applied either intraperitoneally or locally, as a thin cream layer, immediately after injury (sacrifice at 2 h), and once a day for 14 days.


RESULTS
BPC 157 improved muscle healing, macroscopically (less hematoma and edema, no post-injury leg contracture), microscopically, functionally, and also based on enzyme activity (creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase).


CONCLUSIONS
BPC 157, at all investigated intervals, given locally or intraperitoneally, accelerated post-injury muscle healing and also helped to restore the full function.
Novinscak
Tomislav
T
Department of Pharmacology, Institute of Pathology, University of Zagreb Medical School, Salata 11, 10 000, Zagreb, Croatia.
Brcic
Luka
L
Staresinic
Mario
M
Jukic
Ivana
I
Radic
Bozo
B
Pevec
Danira
D
Mise
Sandro
S
Tomasovic
Sanja
S
Brcic
Iva
I
Banic
Tihomir
T
Jakir
Ana
A
Buljat
Gojko
G
Anic
Tomislav
T
Zoricic
Ivan
I
Romic
Zeljko
Z
Seiwerth
Sven
S
Sikiric
Predrag
P
D000125:Achilles Tendon / Q000187:drug effects* / Q000293:injuries / Q000503:physiopathology; D000818:Animals; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011506:Proteins / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function; D018709:Statistics, Nonparametric; D013314:Stress, Mechanical; D013708:Tendon Injuries / Q000188:drug therapy* / Q000503:physiopathology; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D010446:Peptide Fragments; D011506:Proteins; C083833:BPC 157