[Habituation of caddies Chaetopteryx villosa larvae to vibrational stimulus and effect of piracetam on it].
Habituation to a vibrational stimulus was studied in intact caddies Chaetopteryx villosa Fabr. of the last age before pupation and of the larvae placed for 72 h into pyracetam solution (100 mg/l). The vibrational stimulus was shown to produce a passive-defensive reaction: the caddies were pulled into the house and stood still. In the course of the experiment the time of stay in the house decreased statistically significantly in both groups. Pyracetam did not affect the defensive reaction at the initial moment of the first vibrational stimulus, so both in the experimental and in the control groups the number of contracted larvae was equal and all of them remained in the house for the first seconds of vibration. However, the compound increased the number of larvae that did not respond to the next vibrational stimulus and decreased the number of larvae that remain in the house throughout all 10 s of action by accelerating on the whole the habituation. Hence, on this model, the mnemotropic effect of the standard nootrope has been realized, which earlier was established by other methods in mammals, the lower vertebrates, and the higher invertebrates. This indicates that this model also is perspective for comparative studies of effect of nootropic substances on the higher nervous activity.
Inozemtsev
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Nepomniashchikh
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VA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D007313:Insecta; D007814:Larva; D008954:Models, Biological; D018697:Nootropic Agents / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology*; D013997:Time Factors; D014732:Vibration
D018697:Nootropic Agents; D010889:Piracetam