title: What information should lead to a suspicion of catheter sepsis in HPN?
abstract: OBJECTIVE
  The diagnosis of catheter sepsis in patients on home parenteral nutrition can be difficult and patients often do not present with classical symptoms of pyrexia whilst feeding. This study reviews the clinical and diagnostic criteria needed to diagnose catheter sepsis.
  
  
  METHODS
  A retrospective consecutive notes review of 2 years of patients presenting with catheter infections assessed symptoms, inflammatory markers and some liver function tests. The same data was also collected on those same patients who had successfully under gone line salvage. The two sets were compared using the Mann-Whitney U-test and predictive calculations were carried out using receiver operated characteristic curves.
  
  
  RESULTS
  Over the two year period there were 37 episodes of CRBSI in 31 patients recorded. Successful catheter salvage was achieved in 30 episodes (in 24 patients) which is an 81% salvage rate. The most significant abnormality seen was a raised C-reactive protein, but less than a third of patients had a raised white cell count. However, there were significant changes in the bilirubin (p=0.0007) and albumin (p=0.0013) in these patients. Almost a third of patients who feel unwell do not present with a raised temperature.
  
  
  CONCLUSIONS
  The diagnosis of CRBSI remains difficult, but it should be suspected in patients with newly abnormal CRP, albumin or bilirubin and in the non-specifically unwell patient a clinician should not be misled by a normal white cell count and apyrexia.
authors.affiliation: Intestinal Failure Unit, Hope Hospital, Stott Lane, M6 8HD, UK.
authors.forename: Anna
authors.initials: A
authors.lastname: Clare
authors.forename: Antje
authors.initials: A
authors.lastname: Teubner
authors.forename: Jon L
authors.initials: JL
authors.lastname: Shaffer
mesh_terms: D001663:Bilirubin / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation; D002408:Catheters, Indwelling / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004866:Equipment Contamination; D006801:Humans; D007958:Leukocyte Count; D008111:Liver Function Tests; D016331:Parenteral Nutrition, Home / Q000295:instrumentation; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D018805:Sepsis / Q000097:blood / Q000175:diagnosis*; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D012709:Serum Albumin; D002097:C-Reactive Protein; D001663:Bilirubin