title: Sensitivity and specificity of urinary cannabinoid detection with two immunoassays after controlled oral administration of cannabinoids to humans.
abstract: For forensic and clinical toxicologic purposes, cannabis consumption is screened using easy-to-handle immunoassays. The sensitivity and specificity of these immunoassays have not yet been established in samples from volunteers receiving oral synthetic tetrahydrocannabinol or cannabis extracts using liquid chromatography-mass spectrometry/mass spectrometry as the reference method. Urine samples were collected in an open, randomized, single-center, three-period crossover study including 18 healthy male volunteers given either 20 mg synthetic tetrahydrocannabinol (Marinol) as a control substance or five different types of Cannabis sativa extracts.
authors.affiliation: Clinical Chemical Laboratory, Section of Toxicology, University Hospital Basel, Basel, Switzerland.
authors.forename: Sandra B
authors.initials: SB
authors.lastname: Grauwiler
authors.forename: Jürgen
authors.initials: J
authors.lastname: Drewe
authors.forename: André
authors.initials: A
authors.lastname: Scholer
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002138:Calibration; D002186:Cannabinoids / Q000008:administration & dosage / Q000652:urine*; D002188:Cannabis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003429:Cross Reactions; D013759:Dronabinol / Q000008:administration & dosage / Q000652:urine; D006801:Humans; D006868:Hydrolysis; D007118:Immunoassay; D008297:Male; D010936:Plant Extracts / Q000493:pharmacokinetics; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000652:urine; D011786:Quality Control; D012372:ROC Curve; D012015:Reference Standards; D012996:Solutions; D053719:Tandem Mass Spectrometry; D055815:Young Adult
chemical_list: D002186:Cannabinoids; D010936:Plant Extracts; D011619:Psychotropic Drugs; D012996:Solutions; D013759:Dronabinol