title: [Parathyroid carcinoma: multicenter study of 17 patients].
abstract: OBJECTIVE
  To evaluate clinical characteristics and survival of patients treated for parathyroid carcinoma.
  
  
  METHODS
  A retrospective multicenter chart review of patients treated for parathyroid carcinoma between January 1979 and January 2005.
  
  
  RESULTS
  17 patients (10 women, 7 men) presenting with parathyroid carcinoma underwent surgical resection. Symptoms were largely related to hypercalcemia. Mean postoperative follow-up was seven years. Local recurrence was noted in four patients (24%) and three patients had late distant metastasis (18%). At the end of the study, nine patients were alive without evidence of recurrence (53%) and one patient was alive with recurrence at 5 years. Seven patients had died, four of whom died as a result of their parathyroid disease.
  
  
  CONCLUSIONS
  Even when symptoms and findings are suggestive, the diagnosis of parathyroid carcinoma is oftentimes difficult. An adequate resection at the first intervention (complete tumor resection including a homolateral thyroid lobectomy and parathyroidectomy with resection of central lymph nodes) is recommended.
authors.affiliation: Service de chirurgie viscérale et endocrinienne, CHU Angers - Angers.
authors.forename: S
authors.initials: S
authors.lastname: Mucci-Hennekinne
authors.forename: G
authors.initials: G
authors.lastname: Desolneux
authors.forename: F
authors.initials: F
authors.lastname: Luyckx
authors.forename: H
authors.initials: H
authors.lastname: Gibelin
authors.forename: E
authors.initials: E
authors.lastname: Mirallié
authors.forename: L
authors.initials: L
authors.lastname: De Calan
authors.forename: J-L
authors.initials: JL
authors.lastname: Kraimps
authors.forename: A
authors.initials: A
authors.lastname: Hamy
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010282:Parathyroid Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies