title: Ascorbic acid induces furanocoumarin production in organ cultures of Glehnia littoralis.
abstract: Exogenously supplied ascorbic acid (AsA) strongly induced furanocoumarin production in leaf and root cultures of GLEHNIA LITTORALIS, but not in cell suspension cultures, after 24 h of treatment. The dose dependency showed that both organ tissues responded well to AsA supplied at concentrations of 10 - 40 mM. For induction of furanocoumarin production, roots required contact with AsA for at least 6 h and productivity markedly increased after 8 h of treatment. This is the first report of the induction of furanocoumarin biosynthesis by AsA alone and of the detection of furanocoumarin biosynthesis in a root culture system.
authors.affiliation: Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Ishikawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Kitamura
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D019661:Apiaceae / Q000187:drug effects* / Q000378:metabolism; D001205:Ascorbic Acid / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D011564:Furocoumarins / Q000096:biosynthesis* / Q000737:chemistry; D018515:Plant Leaves / Q000187:drug effects / Q000378:metabolism; D018517:Plant Roots / Q000187:drug effects / Q000378:metabolism
chemical_list: D000975:Antioxidants; D011564:Furocoumarins; D001205:Ascorbic Acid