Influence of high level of antibodies to myelin basic protein in female mice on the postnatal development and behavioral reactions of the progeny.
Physical development, behavioral reactions, and training capacity were studied in the progeny of female BALB/c mice with high levels of antibodies to myelin basic protein. The proposed protocol of immunization ensures high levels of antibodies to myelin basic protein in this mouse strain. High level of antibodies to myelin basic protein in pregnant females causes an increase in the blood level of these antibodies in the progeny. Inhibitory effect of antibodies to myelin basic protein on physical development, training process, and memory in mouse pups was detected.
Morozov
S G
SG
N. E. Bauman Municipal Clinical Hospital No. 29, Health Care Department, Moscow.
Gribova
I E
IE
Klushnik
T P
TP
Sidyakin
A A
AA
Gnedenko
B B
BB
Toropygin
I Yu
IY
Fadeev
D A
DA
Zozulya
S A
SA
Kovernaya
E I
EI
Sarmanova
Z V
ZV
D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000097:blood / Q000276:immunology*; D001522:Behavior, Animal; D002417:Cattle; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity; D004676:Myelin Basic Protein / Q000276:immunology* / Q000502:physiology; D011247:Pregnancy
D000906:Antibodies; D004676:Myelin Basic Protein