Tubulointerstitial nephritis and uveitis (TINU) syndrome caused by the Chinese herb "Goreisan".
A 58-year-old man was admitted to our hospital complaining of fever and arthralgia. His clinical course and marked ciliary hyperemia led us to suspect tubulointestinal nephritis and uveitis (TINU) syndrome, which was confirmed ophthalmologically and by renal biopsy. Results of a drug-induced lymphocyte-stimulating test were positive for the Chinese herb "Goreisan." This is the first case in which the use of "Goreisan" was causally related to TINU syndrome.
Suzuki
Hisa
H
Department of Internal Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-Hondori, Miyakojima, Osaka, Japan. hisa406coupe@yahoo.co.jp
Yoshioka
Katsunobu
K
Miyano
Masato
M
Maeda
Isseki
I
Yamagami
Keiko
K
Morikawa
Takashi
T
Okada
Noriyuki
N
Konishi
Yoshio
Y
Imanishi
Masahito
M
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018771:Arthralgia / Q000139:chemically induced; D001706:Biopsy; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005334:Fever / Q000139:chemically induced; D005451:Fluorescein Angiography; D006801:Humans; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000473:pathology; D008297:Male; D020835:Medicine, Kampo; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D013577:Syndrome; D014605:Uveitis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D001613:beta 2-Microglobulin / Q000652:urine
D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D001613:beta 2-Microglobulin; C111129:gorei-san