title: Placental transfer of DDT in mother-infant pairs from Northern Thailand.
abstract: The present study objective was to investigate ratios and correlation coefficients between dichlorodiphenyltrichloroethane (DDT) compounds in cord and maternal sera of mother-infant pairs from northern Thailand. The study site was located in Chiang Dao District of Chiang Mai Province which was an agricultural and former malaria endemic area. DDT compounds were analyzed in 88 cord and maternal serum samples using gas chromatography-electron capture detection (GC-ECD). p,p'-DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene) was the major component and detected in every cord and maternal serum samples with geometric means of 1,255 and 1,793 n g(-1) lipids, respectively. p,p'-DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane) was detected at 89.8 and 100% of cord and maternal serum samples, respectively. The second and third highest levels detected were p,p'-DDD (1,1-dichloro-2,2-bis(p-chlorophenyl)ethane) and p,p'-DDT, respectively. The ratios between cord and maternal sera for p,p'-DDE, p,p'-DDT, and p,p'-DDD that were less than 1 had high correlation coefficients (ratio = 0.70, r = 0.82 for p,p'-DDE, ratio = 0.62, r = 0.66 for p,p'-DDT, and ratio = 0.79, r = 0.78 for p,p'-DDD). The high correlation coefficients indicate that cord serum levels of DDT compounds could be accurately estimated from maternal serum levels. It can be concluded that cord serum levels of p,p'-DDE, p,p'-DDT, and p,p'-DDD were approximately 70%, 62%, and 79% of maternal serum levels, respectively. Furthermore, our findings can be applied in public health to monitor and evaluate risk among infants from high DDT exposure area.
authors.affiliation: Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Ratana
authors.initials: R
authors.lastname: Sapbamrer
authors.forename: Tippawan
authors.initials: T
authors.lastname: Prapamontol
authors.forename: Ookaew
authors.initials: O
authors.lastname: Prakobvitayakit
authors.forename: Yuthsak
authors.initials: Y
authors.lastname: Vaneesorn
authors.forename: Ampica
authors.initials: A
authors.lastname: Mangklabruks
authors.forename: Bertold
authors.initials: B
authors.lastname: Hock
mesh_terms: D003632:Dichlorodiphenyldichloroethane / Q000097:blood / Q000633:toxicity; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity; D005260:Female; D005312:Fetal Blood / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007306:Insecticides / Q000097:blood / Q000633:toxicity; D008431:Maternal-Fetal Exchange / Q000187:drug effects* / Q000502:physiology; D009035:Mothers; D010920:Placenta / Q000098:blood supply / Q000187:drug effects*; D011247:Pregnancy; D018570:Risk Assessment; D013785:Thailand
chemical_list: D004785:Environmental Pollutants; D007306:Insecticides; D003632:Dichlorodiphenyldichloroethane