Effects of anti-inflammatory drugs on increased vascular permeability in acute inflammatory response in the chicken.
The effects of anti-inflammatory drugs were examined on the turpentine-induced acute inflammatory response in the chicken skin. An increase in vascular permeability was evaluated using the 'dye' technique. Although histamine and 5-hydroxytryptamine (5-HT) appeared to be the major mediators of the permeability response in the early phase, involvement of 5-HT was more significant. Use of other anti-inflammatory drugs suggested mediation of the permeability response also through the release of prostaglandins or leukotrienes, or both.
Jain
N K
NK
Department of Pathology, College of Veterinary Science and Animal Husbandry, Jabalpur, India.
Vegad
J L
JL
Katiyar
A K
AK
Awadhiya
R P
RP