Prediction of binding sites in receptor-ligand complexes with the Gaussian Network Model.
Residues at the binding sites of the ligand and receptor of several enzyme-inhibitor and antibody-antigen complexes are predicted from the slowest (for the ligand) and fastest (for the receptor) modes of motion by the Gaussian Network Model applied to unbound molecules.
Haliloglu
Turkan
T
Polymer Research Center, Bogazici University, Bebek, Istanbul, Turkey.
Seyrek
Emek
E
Erman
Burak
B
D000936:Antigen-Antibody Complex / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D008954:Models, Biological; D008956:Models, Chemical; D008958:Models, Molecular; D013329:Structure-Activity Relationship
D000936:Antigen-Antibody Complex; D004791:Enzyme Inhibitors; D004798:Enzymes; D008024:Ligands