Successful thalamic deep brain stimulation for orthostatic tremor.
We report a patient with severe orthostatic tremor (OT) unresponsive to pharmacological treatments that was successfully controlled with thalamic (Vim, ventralis intermedius nucleus) deep brain stimulation (DBS) over a 4-year period. Cortical activity associated with the OT revealed by EEG back-averaging and fluoro-deoxi-glucose PET were also suppressed in parallel with tremor arrest. This case suggests that Vim-DBS may be a useful therapeutic approach for patients highly disabled by OT.
Guridi
Jorge
J
Department of Neurology, Neurophysiology and Neurosurgery, Clínica Universitaria, Universidad de Navarra, Pamplona, Spain.
Rodriguez-Oroz
Maria C
MC
Arbizu
Javier
J
Alegre
Manuel
M
Prieto
Elena
E
Landecho
Ignacio
I
Manrique
Miguel
M
Artieda
Julio
J
Obeso
Jose A
JA
D046690:Deep Brain Stimulation / Q000379:methods*; D004244:Dizziness / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013788:Thalamus / Q000502:physiology*; D014202:Tremor / Q000150:complications / Q000628:therapy*