title: The pleural and human fibrin glue sandwich: a quick and effective post-pneumonectomy bronchial stump coverage technique.
abstract: BACKGROUND
  Protection of the bronchial stump after pneumonectomy reduces the incidence of bronchopleural fistula. However, which technique provides the most satisfactory results remains open for debate.
  
  
  METHODS
  We describe a study in which a bronchial stump coverage technique was performed using 2 layers of human fibrin glue (Tissucol; Baxter, Deerfield, IL USA) with an interposed patch of parietal pleura. From July 2005 to June 2007, this technique was used in 31 consecutive patients after standard pneumonectomy by a single surgeon.
  
  
  RESULTS
  None of the patients developed early or late bronchopleural fistula, and no clinical adverse reaction was recorded. During the same period, alternative stump coverage techniques were used by different surgeons in 71 pneumonectomies. In this group, the rate of fistula was 6% (4 patients).
  
  
  CONCLUSIONS
  These preliminary data demonstrate the feasibility of the technique and suggest that it is at least equivalent to the other type of flaps used. The main advantages of this technique are the restoration of the natural separation between the mediastinum and pleural cavities, as well as the reduced operating time (duration 5 minutes).
authors.affiliation: Thoracic Surgery Department, European Institute of Oncology, via Ripamonti 435, 20100 Milan, Italy. francesco.leo@ieo.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Leo
authors.forename: Domenico
authors.initials: D
authors.lastname: Galetta
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Spaggiari
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001983:Bronchial Fistula / Q000209:etiology / Q000517:prevention & control*; D005240:Feasibility Studies; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000009:adverse effects* / Q000379:methods; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive