How messengers modulate the shifting of spontaneously generated action potential into bursts of potentials in central snail neuron?
How messengers modulate the shifting of spontaneously generated action potential into bursts of potentials (BoP) is studied electrophysiologically and biochemically in RP 1 and 4 neurons of the African snail, Achatina fulica Ferussac using d- and l-amphetamine (Amp) as modulator. The stereospecific effects, extracellular and intracellular ionic effects, messenger related to enzymatic effects and membrane ionic currents effects on BoP elicited by Amp are studied. The roles of organelles, such as mitochondria, protein syntheis related endoplasmic-reticulum, on the BoP are also tested. The messengers modulated the BoP are discussed.
Tsai
M C
MC
Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan. mctsai@ccms.ntu.edu.tw
D000200:Action Potentials / Q000187:drug effects; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008959:Models, Neurological; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009865:Oocytes / Q000378:metabolism; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics / Q000378:metabolism; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D015290:Second Messenger Systems / Q000187:drug effects; D012908:Snails / Q000166:cytology / Q000378:metabolism*; D014981:Xenopus; D000099161:Kcnj11 Channel
D000661:Amphetamine; D024661:Potassium Channels, Inwardly Rectifying; D011994:Recombinant Proteins; D000099161:Kcnj11 Channel