title: Eosinophilic myocarditis temporally associated with conjugate meningococcal C and hepatitis B vaccines in children.
abstract: We report the first cases of tissue-proven eosinophilic myocarditis after single vaccine administration of conjugate meningococcal C and hepatitis B vaccine, respectively. The nature of histopathologic findings strongly supports hypersensitivity reaction and negates viral etiology, which is typically characterized by a lymphocytic infiltrate. Both episodes resolved with corticosteroid therapy. To enhance discussion of our cases, we performed a systematic review of the literature on postimmunization myocarditis or pericarditis, and identified 37 publications, reporting 269 cases during the search period (1966-2007). Time of onset of cardiac symptoms in all patients ranged from 1 to 30 days postimmunization.
authors.affiliation: Division of Infectious Diseases, the Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada.
authors.forename: Michelle
authors.initials: M
authors.lastname: Barton
authors.forename: Yaron
authors.initials: Y
authors.lastname: Finkelstein
authors.forename: Mary Anne
authors.initials: MA
authors.lastname: Opavsky
authors.forename: Shinya
authors.initials: S
authors.lastname: Ito
authors.forename: Tommy
authors.initials: T
authors.lastname: Ho
authors.forename: Lee E
authors.initials: LE
authors.lastname: Ford-Jones
authors.forename: Glenn
authors.initials: G
authors.lastname: Taylor
authors.forename: Lee
authors.initials: L
authors.lastname: Benson
authors.forename: Ronald
authors.initials: R
authors.lastname: Gold
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D006967:Hypersensitivity; D022401:Meningococcal Vaccines / Q000009:adverse effects*; D009205:Myocarditis / Q000276:immunology / Q000473:pathology*
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D017325:Hepatitis B Vaccines; D022401:Meningococcal Vaccines; C410218:serogroup C meningococcal conjugate vaccine