title: A cytotoxic and apoptosis-inducing sesquiterpenoid isolated from the aerial parts of Artemisia princeps PAMPANINI (Sajabalssuk).
abstract: Repeated silica gel and octadecyl silica gel (ODS) column chromatography of the aerial parts of Artemisia princeps PAMPANINI (Sajabalssuk) led to the isolation of a new sesquiterpenoid, 3-((S)-2-methylbutyryloxy)-costu-1(10),4(5)-dien-12,6 alpha-olide (2), along with two previously reported sesquiterpenoids: 8 alpha-angeloyloxy-3beta,4 beta-epoxy-6 beta H,7 alpha H,8 beta H-guaia-1(10),11(13)-dien-12,6 alpha-olide (1, carlaolide B) and 3beta,4 beta-epoxy-8 alpha-isobutyryloxy-6 beta H,7 alpha H,8 beta H-guaia-1(10),11(13)-dien-12,6 alpha-olide (3, carlaolide A). The structure of compound 2 was elucidated by spectroscopic data analysis, including one dimensional (1D) and two dimensional (2D) nuclear magnetic resonance (NMR) experiments. Of the isolates, compound 2 exhibited potent cytotoxicity against human cervix adenocarcinoma cells and induced apoptosis.
authors.affiliation: The Skin Biotechnology Center, Kyung Hee University, Suwon, Korea.
authors.forename: Myun-Ho
authors.initials: MH
authors.lastname: Bang
authors.forename: Min-Woo
authors.initials: MW
authors.lastname: Han
authors.forename: Myoung-Chong
authors.initials: MC
authors.lastname: Song
authors.forename: Jin-Gyeong
authors.initials: JG
authors.lastname: Cho
authors.forename: Hae-Gon
authors.initials: HG
authors.lastname: Chung
authors.forename: Tae-Sook
authors.initials: TS
authors.lastname: Jeong
authors.forename: Kyung-Tae
authors.initials: KT
authors.lastname: Lee
authors.forename: Myung-Sook
authors.initials: MS
authors.lastname: Choi
authors.forename: Se-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology*; D017209:Apoptosis / Q000235:genetics*; D019306:Artemisia / Q000737:chemistry*; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D006801:Humans; D015394:Molecular Structure; D045789:Sesquiterpenes, Guaiane / Q000302:isolation & purification* / Q000633:toxicity; D014407:Tumor Cells, Cultured
chemical_list: D045789:Sesquiterpenes, Guaiane