title: Initial human herpesvirus-8 rash and multicentric Castleman disease.
abstract: We describe a human immunodeficiency virus-infected man with relapsing rashes and reactivation of human herpesvirus-8 (HHV-8) infection, which evolved into multicentric Castleman disease. Initial skin biopsy revealed infiltrating HHV-8-positive plasmablasts, a subset of which supported lytic infection. We document the first case, to our knowledge, of HHV-8-induced rash and suggest that circulating plasmablasts drive HHV-8 to target tissues.
authors.affiliation: Unité des Maladies Infectieuses et Tropicales, Hôpital Paul Brousse, Villejuif, Paris, France. benjamin.wyplosz@pbr.aphp.fr
authors.forename: Benjamin
authors.initials: B
authors.lastname: Wyplosz
authors.forename: Agnès
authors.initials: A
authors.lastname: Carlotti
authors.forename: Lélia
authors.initials: L
authors.lastname: Escaut
authors.forename: Nicolas
authors.initials: N
authors.lastname: Vignier
authors.forename: Catherine
authors.initials: C
authors.lastname: Guettier
authors.forename: Félix
authors.initials: F
authors.lastname: Agbalika
authors.forename: Daniel
authors.initials: D
authors.lastname: Vittecoq
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dupin
mesh_terms: D000368:Aged; D005871:Castleman Disease / Q000209:etiology*; D005076:Exanthema / Q000209:etiology*; D006566:Herpesviridae Infections / Q000150:complications* / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D010950:Plasma Cells / Q000821:virology; D012867:Skin / Q000473:pathology