Membranoproliferative glomerulonephritis in a girl and her mother.
A girl and her mother were diagnosed as having membranoproliferative glomerulonephritis (MPGN) type I. Microscopic hematuria and proteinuria presented at 9 years of age in the mother and at 14 years in the daughter. Both had persistent hypocomplementemia and were treated with steroids. When the mother was 40 years old, proteinuria was still continuing and creatinine clearance was 64.4 ml/min per 1.73 m(2). When the daughter was 15 years old, microscopic hematuria was still continuing. To our knowledge, familial cases of MPGN in two generations have not been reported in Japan.
Motoyama
Osamu
O
Department of Pediatrics, Toho University Medical Center, Sakura Hospital, 564-1 Shimoshizu, Sakura, Chiba, Japan. motoyan@basil.ocn.ne.jp
Sakai
Ken
K
Ohashi
Yasushi
Y
Mizuiri
Sonoo
S
Hatori
Tsutomu
T
Iitaka
Kikuo
K
Koitabashi
Yasushi
Y
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D003165:Complement System Proteins / Q000276:immunology; D003404:Creatinine / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D010375:Pedigree; D011247:Pregnancy; D011507:Proteinuria / Q000209:etiology; D013256:Steroids / Q000627:therapeutic use
D013256:Steroids; D003165:Complement System Proteins; D003404:Creatinine