Considerations for selecting the correct animal model for dermal wound-healing studies.
An array of animal models has been described to elucidate wound-healing processes and access the impact of various therapies on healing. However, which model to use for different applications may not be immediately apparent. This article will highlight less frequently used animal models so as to illustrate their utility and increase their use. Selection of an animal model should include consideration of inter-species anatomical and physiological attributes that may confound data interpretation, differences in how different types of wounds heal, and sample size and analytical techniques to be applied. Importantly, the use of human beings should be considered, as techniques have been developed that allow for histological, biochemical and molecular analyses of healing parameters on a scale that could be used in humans.
Lindblad
William J
WJ
Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy & Health Sciences, 179 Longwood Avenue, Boston, MA 02115-5896, USA. william.lindblad@mcphs.edu
D000818:Animals; D001672:Biocompatible Materials; D020405:Dermis / Q000378:metabolism*; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D006801:Humans; D051379:Mice; D008953:Models, Anatomic; D023421:Models, Animal; D019736:Prostheses and Implants; D012828:Silicones / Q000737:chemistry; D012867:Skin / Q000293:injuries / Q000473:pathology; D013552:Swine; D014945:Wound Healing / Q000502:physiology*
D001672:Biocompatible Materials; D012828:Silicones