Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men.
The reproductive phenotypes of nearly two dozen patients with mutations in GPR54 have been reported, as have the phenotypes of four mouse lines mutant for Gpr54 and two lines mutant for Kiss1. These phenotypes demonstrate that kisspeptin/Gpr54 function is required at all phases of the life cycle when the secretion of gonadotropin-releasing hormone (GnRH) is robust. Furthermore, there is phenotypic variability ranging from severe hypogonadism to partial sexual development. Collectively, these findings suggest that kisspeptin and Gpr54 serve as an essential conduit for relaying developmental information to the GnRH neuron.
Chan
Yee-Ming
YM
Reproductive Endocrine Unit and Harvard Reproductive Sciences Center, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Broder-Fingert
Sarabeth
S
Seminara
Stephanie B
SB
D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D005260:Female; D005298:Fertility / Q000502:physiology; D006801:Humans; D007006:Hypogonadism / Q000235:genetics / Q000503:physiopathology; D059648:Kisspeptins; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D010641:Phenotype; D011627:Puberty / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D000074502:Receptors, Kisspeptin-1; D012098:Reproduction / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*; D055815:Young Adult
C106628:KISS1 protein, human; C118688:KISS1R protein, human; D059648:Kisspeptins; D043562:Receptors, G-Protein-Coupled; D000074502:Receptors, Kisspeptin-1; D025521:Tumor Suppressor Proteins