Living-related liver transplantation in children--a single center evaluation of the outcome of donor candidates and recipients.
The aim was to study the outcome of donor candidate investigations for living-related donor liver transplantation from adult to child. The charts of 25 donor candidates were reviewed. All 22 recipients, of whom 18 had BA, were already listed for DD organ transplantation. Eleven donor candidates were accepted. Seven of them successfully donated the left lateral liver segment. At follow-up, all donors and recipients were well from the surgery. However, one donor developed Crohn's disease. In the four remaining cases the recipient deteriorated before transplantation was possible or other surgical approaches were utilized. For three candidates the investigations were never finalized, due to either clinical deterioration of the recipient or the availability of a DD organ. Eleven donor candidates were rejected. Four of them (three being parents of BA patients) had liver abnormalities. Another three were rejected for cardiopulmonary disorders and the remaining four for other reasons. We conclude that only seven out of 25 (28%) candidates donated a liver segment. The fact that parents of BA patients have potential liver pathology may be of importance for the understanding of the etiology of the disease and have possible implications for the choice of donors.
Fischler
Björn
B
Department of Pediatrics, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden. bjorn.fischler@karolinska.se
Johansson
Magnus
M
Gjertsen
Henrik
H
Ericzon
Bo-Göran
BG
Bergquist
Annika
A
Broome
Ulrika
U
Nemeth
Antal
A
D000293:Adolescent; D000328:Adult; D001656:Biliary Atresia / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003424:Crohn Disease / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D008099:Liver / Q000002:abnormalities / Q000821:virology; D008107:Liver Diseases / Q000628:therapy; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D016896:Treatment Outcome; D014777:Virus Diseases / Q000473:pathology