14th International HLA and Immunogenetics Workshop Prospective Chronic Rejection Project: a three-year follow-up analysis.
The three-year follow-up of 4,144 patients of the 14th International Workshop Prospective Chronic Rejection study has reinforced the evidence that post-transplant HLA antibodies are predictive of long-term graft loss. Three years after a single testing for HLA antibodies, 10% of kidney recipients who were antibody-positive had lost their grafts, in contrast to only 5% of antibody-negative patients (p<0.0001). The adverse effect of post-transplant antibodies on graft survival was also observed in lung, heart, and liver transplants. Donor-specific antibodies and 'strong' non-DSA had stronger association with graft loss than 'moderate' non-DSA. Periodic antibody monitoring, combined with specificity and strength analysis, would help in the early identification of allograft recipients who are at high risk of graft failure.
Ozawa
M
M
One Lambda, Inc., Los Angeles, CA, USA.
Terasaki
P I
PI
Castro
R
R
Alberu
J
J
Morales-Buenrostro
L
L
Alvarez
I
I
Toledo
R
R
Alvez
H
H
Monteiro
M
M
Teixeira
J
J
Campbell
P
P
Ciszek
M
M
Charron
D
D
Gautreau
C
C
Christiansen
F
F
Langan
L
L
Conca
R
R
Grosse-Wilde
H
H
Heinemann
F
F
Kamoun
M
M
Kobayashi
T
T
Kupatawintu
P
P
LeFor
W
W
Mehra
N
N
Panigrahi
A
A
Norman
D
D
Piazza
A
A
Poli
F
F
Roy
R
R
Schonemann
C
C
Lachmann
N
N
Sireci
G
G
Tanabe
K
K
Ishida
H
H
Van den Berg-Loonen
E
E
Zeevi
A
A
D002908:Chronic Disease; D004493:Education; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000276:immunology*; D006085:Graft Survival / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D016027:Heart Transplantation / Q000276:immunology / Q000706:statistics & numerical data; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000276:immunology / Q000706:statistics & numerical data; D016040:Lung Transplantation / Q000276:immunology / Q000706:statistics & numerical data; D016377:Organ Transplantation / Q000706:statistics & numerical data*; D011446:Prospective Studies
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A