title: Sonophotocatalysis of endocrine-disrupting chemicals.
abstract: Sonolysis and photolysis often exhibit synergistic effects in the degradation of organic molecules. An assay of fish oocyte maturation provides an appropriate experimental system to investigate the hormonal activities of chemical agents. Oocyte maturation in fish is triggered by maturation-inducing hormone (MIH), which acts on receptors on the oocyte surface. A synthetic estrogen, diethylstilbestrol (DES), possesses inducing activity of fish oocyte maturation, and a widely used biocide, pentachlorophenol (PCP), exhibits a potent inhibitory effect on fish oocyte maturation. In this study, the effects of the combined treatment by sonolysis with photolysis (sonophotocatalysis) to diminish the hormonal activity of DES and the maturation preventing activity of PCP was examined. By sonophotocatalysis, hormonal activity of DES was completely lost within 30 min and the inhibiting activity of PCP was lost within 120 min. These results demonstrated that sonophotocatalysis is effective for diminishing the endocrine-disrupting activity of chemical agents.
authors.affiliation: Department of Biology, Faculty of Science, National University Corporation Shizuoka University, Shizuoka 422-8529, Japan. sbttoku@ipc.shizuoka.ac.jp
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Tokumoto
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Furusawa
authors.forename: Sanae
authors.initials: S
authors.lastname: Ii
authors.forename: Kaori
authors.initials: K
authors.lastname: Hachisuka
authors.forename: Mika
authors.initials: M
authors.lastname: Tokumoto
authors.forename: Huai-Jen
authors.initials: HJ
authors.lastname: Tsai
authors.forename: Shigeo
authors.initials: S
authors.lastname: Uchida
authors.forename: Akinori
authors.initials: A
authors.lastname: Maezawa
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified / Q000254:growth & development; D004054:Diethylstilbestrol / Q000737:chemistry / Q000528:radiation effects / Q000633:toxicity*; D052244:Endocrine Disruptors / Q000737:chemistry / Q000528:radiation effects / Q000633:toxicity*; D005260:Female; D008027:Light; D009865:Oocytes / Q000187:drug effects / Q000254:growth & development; D010416:Pentachlorophenol / Q000737:chemistry / Q000528:radiation effects / Q000633:toxicity*; D013010:Sonication; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000528:radiation effects / Q000633:toxicity*; D015027:Zebrafish / Q000235:genetics / Q000254:growth & development*
chemical_list: D052244:Endocrine Disruptors; D014874:Water Pollutants, Chemical; D004054:Diethylstilbestrol; D010416:Pentachlorophenol