Polymorphisms of the DNA repair gene XPA and XPC and its correlation with gastric cardiac adenocarcinoma in a high incidence population in North China.
OBJECTIVE
Investigated the association of DNA repair gene xeroderma pigmentosum group A(XPA) and C(XPC) polymorphisms with the risk of gastric cardiac adenocarcinoma (GCA) in a high incidence region in north China.


BACKGROUND
Polymorphisms of a number of DNA repair genes may contribute to variations in DNA repair capacity and genetic susceptibility to different cancers.


METHODS
Two single nucleotide polymorphisms of XPA and 3 single nucleotide polymorphisms of XPC were genotyped in 253 GCA patients and 612 healthy controls.


RESULTS
Family history of upper gastrointestinal cancer may increase the risk of developing GCA. Compared with A/A genotype, A/G+G/G genotype of XPA A23G significantly decreased the risk of developing GCA especially in nonsmoker group. The genotype and allelotype distributions of XPC intron 9 PAT+/- and exon 15 Lys939Gln in GCA patients were not significantly different from that in healthy controls (P>0.05). T allelotype frequencies of XPC exon 8 Val499Ala in GCA patients was significantly lower than that in healthy controls (P<0.05). The C/T genotype frequency of XPC exon 8 in GCA patients (35.6%) was significantly different from that in healthy controls (46.1%) (P=0.01). Compared with individuals with C/C genotype, individuals with T allele (C/T or T/T genotype) had significantly lower risk in developing GCA. We also found that polymorphisms of this 3 XPC locus were in linkage disequilibrium.


CONCLUSIONS
XPA A23G and XPC exon 8 Val499Ala polymorphisms may be useful markers for identifying individuals at risk of developing GCA in the high incidence region of north China.
Dong
Zhiming
Z
Department of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Guo
Wei
W
Zhou
Rongmiao
R
Wan
Lingling
L
Li
Yan
Y
Wang
Na
N
Kuang
Gang
G
Wang
Shijie
S
D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics*; D000368:Aged; D000483:Alleles; D002681:China / Q000453:epidemiology; D004268:DNA-Binding Proteins / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics*; D051760:Xeroderma Pigmentosum Group A Protein / Q000235:genetics*
D004268:DNA-Binding Proteins; C497314:XPA protein, human; D051760:Xeroderma Pigmentosum Group A Protein; C086984:XPC protein, human