Laboratory parameters of Italian centenarians.
A consortium of 20 university departments of geriatrics and gerontology conducted the Italian Multicentric Study on Centenarians (IMSC), in order to assess the socio-economic, clinical and biological conditions of the Italian centenarians. The investigation involved 382 subjects randomly selected from a total of 1162 centenarians (234 men and 928 women), recorded by a census carried out until 31 December, 1993. Their case history, clinical and socio-economic data were recorded on a computerized clinical case sheet. Blood samples for the purpose of the present investigations were drawn from 257 of them. A great proportion (79%) of these latter subjects displayed satisfactory general conditions in their laboratory parameters, 18.3% of them had fairly good clinical conditions even with slightly modified laboratory parameters. Only a low percentage (2.8%) had poor general conditions with a marked anemia, hyperazotemia and uric acid levels. Long duration diabetes was practically absent, and only 5.5% of our centenarians displayed hyperglycemia with a mean duration time of 9.3 years. The prevalence of subjects with hypercholesterolemia was 31.1%. Only 4.3% of centenarians was affected by mixed form of dyslipidemia (hypertriglyceridemia associated with hypercholesterolemia), confirming that elevated blood lipid contents jeopardize really long survival.