Chromosomal abnormalities in couples with reproductive disorders.
OBJECTIVE
To determine the prevalence of chromosomal abnormalities in couples with reproductive disorders.


METHODS
A retrospective study was performed in 939 Mexican couples with reproductive disorders (542 with recurrent fetal loss, 356 with malformed/stillborn children, and 41 with sterility) whose karyotype was established on GTG-banded metaphases.


RESULTS
A chromosomal aberration was detected in one partner of 52 couples, including a double translocation carrier; therefore, the prevalence of chromosomally abnormal couples was 5.5%; 31 couples with recurrent fetal loss (31/542, 5.7%), 15 with malformed/stillborn children (15/356, 4.2%), and 6 with sterility (6/41, 14.6%). There were 43 couples with structural rearrangements (29 reciprocal translocations, 10 robertsonian translocations, 2 inversions, 1 insertion, and 1 ring) and 9 with gonosomal aneuploidies. The affected partner was female in 28 (53.8%) and male in 24 (46.2%) couples. In addition, 17 couples (1.8%) with the structural variant inversion 9qh were detected.


CONCLUSIONS
The prevalence of chromosomal abnormalities found in our sample is consistent with figures described in several populations around the world.
Meza-Espinoza
Juan Pablo
JP
Unidad Academica de Ciencias de la Salud y Tecnologia, Universidad Autonoma de Tamaulipas, Matamoros, Mexico. sirol1073@yahoo.com.mx
Anguiano
Lilia Ortiz
LO
Rivera
Horacio
H
D000026:Abortion, Habitual / Q000235:genetics*; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007246:Infertility / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D050497:Stillbirth / Q000235:genetics*