title: Antifungal activity of micafungin against Candida and Aspergillus spp. isolated from pediatric patients in Japan.
abstract: The in vitro antifungal activities of micafungin in comparison to caspofungin, fluconazole, itraconazole, voriconazole, and amphotericin B were evaluated against 93 Candida and 23 Aspergillus isolates recovered from pediatric patients with fungal infections. MICs were determined by the CLSI M27-A2 and M38-A for Candida and Aspergillus species, respectively. Micafungin showed potent activity against Candida albicans, Candida tropicalis, and Candida glabrata with a MIC range of <= 0.002 to 0.015mug/ml. In contrast, micafungin demonstrated higher MIC levels against Candida parapsilosis with a MIC range of 0.12 to 2 mug/ml. Micafungin showed potent antifungal activity against Aspergillus species tested with a MIC range of 0.004 to 0.015 mug/ml. Overall, micafungin had excellent in vitro antifungal activities against Candida and Aspergillus species recovered from pediatric patients with fungal infections.
authors.affiliation: Chemotherapy Division, Mitsubishi Chemical Medience Corporation, Tokyo. mbc-ka@sa2.so-net.ne.jp
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Ikeda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Saika
authors.forename: Yumie
authors.initials: Y
authors.lastname: Sato
authors.forename: Makoto
authors.initials: M
authors.lastname: Suzuki
authors.forename: Miyuki
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Mikawa
authors.forename: Intetsu
authors.initials: I
authors.lastname: Kobayashi
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Tsuji
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000382:microbiology; D001230:Aspergillus / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan; D055666:Lipopeptides / Q000494:pharmacology*; D008297:Male; D000077551:Micafungin; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin