[Antimutagenes' protection action in human repair-defected cells].
The action of natural (garlick extract, retinol) and of synthetic (crown-compound) antimutagenes in lymphotytes with gamma-radiation-induced inhibition of DNA-damages repair in cases of Elers-Danlos, syndrom, progeria and gomocystinurea was studied. Antimutagen cells defence from mutagenes was shown at all cases except one: progeria cells treated by retinol. Thus the repair-deficient cells resistance against mutagenes could be increased by antimutagenes.
Vasil'eva
I M
IM
Semiachkina
A N
AN
Semenova
S S
SS
Zasukhina
G D
GD
D016587:Antimutagenic Agents / Q000494:pharmacology*; D019256:Cadmium Chloride / Q000009:adverse effects; D002478:Cells, Cultured; D047248:Crown Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects* / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects*; D004535:Ehlers-Danlos Syndrome / Q000235:genetics; D005720:Gamma Rays / Q000009:adverse effects; D005737:Garlic / Q000737:chemistry; D006712:Homocystinuria / Q000235:genetics; D006801:Humans; D008214:Lymphocytes; D010936:Plant Extracts / Q000494:pharmacology*; D011371:Progeria / Q000235:genetics; D014801:Vitamin A / Q000494:pharmacology*
D016587:Antimutagenic Agents; D047248:Crown Compounds; D010936:Plant Extracts; D014801:Vitamin A; D019256:Cadmium Chloride