WRN Cys1367Arg SNP is not associated with risk and prognosis of gliomas in Southeast Brazil.
Werner syndrome (WS) is a premature aging disorder characterized by early onset of symptoms related to normal aging and by a high predisposition to various types of cancer, including gliomas. WS is caused by inherited recessive mutations in the WRN gene, which encodes a helicase considered a caretaker of the genome. Aiming to study the role of WRN Cys1367Arg in glioma susceptibility and oncologic prognosis of patients, we investigated the genotype distribution of this single nucleotide polymorphism in 94 glioma patients and 100 healthy subjects. Comparisons of genotype distributions and allele frequencies did not reveal any significant difference between the groups. Overall and disease-free survival rates were calculated, but no statistically significant difference was observed. Our data suggest that WRN Cys1367Arg SNP is not involved either in susceptibility to developing gliomas or in patient survival, at least in the Brazilian population.
Pinto
Giovanny R
GR
Human Genetics Laboratory, Federal University of Piauí, Av. São Sebastião 2819, 64202-020 Parnaíba, PI, Brazil. pintogr@gmail.com
Yoshioka
France K N
FK
Clara
Carlos A
CA
Santos
Marcelo J
MJ
Almeida
José R W
JR
Burbano
Rommel R
RR
Rey
Juan A
JA
Casartelli
Cacilda
C
D000328:Adult; D001120:Arginine / Q000235:genetics*; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D003545:Cysteine / Q000235:genetics*; D005090:Exodeoxyribonucleases / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D005838:Genotype; D005910:Glioma / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D053484:RecQ Helicases / Q000235:genetics*; D012306:Risk; D016019:Survival Analysis; D000071657:Werner Syndrome Helicase
D001120:Arginine; D005090:Exodeoxyribonucleases; D053484:RecQ Helicases; C098785:WRN protein, human; D000071657:Werner Syndrome Helicase; D003545:Cysteine