[Absorption of extractive Rhizoma Coptidis in rat everted gut scas].
OBJECTIVE
Using in vitro everted gut seas to research the intestinal absorption of the extractive Rhizoma Coptidis at the different intestinal section and the different density.


METHODS
Berberine (BER) and palmatine (PAL) which are representative compositions of the extractive Rhizoma Coptidis in everted gut seas are detected by HPLC, and calculated the absorption parameter to describe the character of absorption.


RESULTS
The absorption of BER and PAL is linearity in different intestine and different dose, and the square of coefficient correlation exceed 0.9, which consistent with zero order rate process. The K(a) of BER and PAL increases along with the raised dosage of the extractive Rhizoma Coptidis (P < 0.05), indicated it is the passive absorption. The absorption of BER and PAL in the jejunum is the most quick, the ileum and colon are slower.


CONCLUSIONS
In the different dosage of extractive Rhizoma Coptidis, the absorption of BER and PAL Conforms to the zero order rate process at the different intestine, and is the passive absorption.
Dong
Yu
Y
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Zhang
Ying-Feng
YF
Yang
Qing
Q
Li
Yu-Jie
YJ
Bao
Tian-Dong
TD
Weng
Xiao-Gang
XG
Pan
Guo-Feng
GF
Zhu
Xiao-Xin
XX
D000818:Animals; D001599:Berberine / Q000493:pharmacokinetics*; D001600:Berberine Alkaloids / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D002921:Cicatrix / Q000378:metabolism*; D003106:Colon / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D041981:Gastrointestinal Tract / Q000378:metabolism*; D007082:Ileum / Q000378:metabolism; D007583:Jejunum / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; D001599:Berberine; C005413:palmatine