Changes in hemostatic parameters after intranasal administration of peptide Pro-Gly-Pro.
Anticoagulant activity, total and nonenzymatic fibrinolytic activity, and tissue plasminogen activator activity increased, while platelet aggregation and activity of factor XIIIa in rat blood plasma decreased over 3 h after single intranasal administration of proline-containing peptide Pro-Gly-Pro. Hemostatic parameters in rats 24 h after single administration of this peptide did not differ from the control level observed in animals receiving 0.85% NaCl.
Lyapina
L A
LA
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University. lyapinal@mail.ru
Pastorova
V E
VE
Obergan
T Yu
TY
D000281:Administration, Intranasal; D000818:Animals; D026122:Factor XIIIa / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D008297:Male; D009842:Oligopeptides / Q000032:analysis / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D011392:Proline / Q000031:analogs & derivatives* / Q000032:analysis / Q000494:pharmacology; D051381:Rats
D009842:Oligopeptides; C113164:prolyl-glycyl-proline; D011392:Proline; D026122:Factor XIIIa