New lanthanide complexes with antioxidant activity.
The cerium (III), lanthanum (III) and neodymium (III) complexes of 5-aminoorotic acid were synthesized and their structures were determined by means of theoretical study, spectral and physicochemical analysis. Significant differences in the spectra of the complexes were observed as compared to the spectra of the ligand. The ligand and the complexes were tested for the antioxidant activity. The results obtained indicate that the tested compounds exerted a considerable antioxidant effect upon the evaluated radicals' formation in the blood plasma of Wistar rat.
Kostova
Irena
I
Department of Chemistry, Faculty of Pharmacy, Medical University, Sofia, Bulgaria. irenakostova@yahoo.com
Traykova
Maria
M
Rastogi
Vinod K
VK
D000588:Amines / Q000737:chemistry; D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D005609:Free Radicals / Q000097:blood; D007477:Ions / Q000737:chemistry; D028581:Lanthanoid Series Elements / Q000737:chemistry* / Q000494:pharmacology*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009963:Orotic Acid / Q000737:chemistry* / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared
D000588:Amines; D000975:Antioxidants; D005609:Free Radicals; D007477:Ions; D028581:Lanthanoid Series Elements; D008024:Ligands; D009963:Orotic Acid