title: Prenylated dihydrochalcones from Boronia bipinnata that inhibit the malarial parasite enzyme target hemoglobinase II.
abstract: High-throughput screening of a plant and marine invertebrate extract library to find natural products that inhibit the malarial parasite enzyme target hemoglobinase II led to the isolation of two new active prenylated chalcones, bipinnatones A (1) and B (2), from aerial parts of the Queensland shrub Boronia bipinnata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 inhibited hemoglobinase II with IC 50 values of 64 and 52 microM, respectively.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, Queensland, Australia 4111.
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Carroll
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Fechner
authors.forename: Jill
authors.initials: J
authors.lastname: Smith
authors.forename: Gordon P
authors.initials: GP
authors.lastname: Guymer
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000818:Animals; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000201:enzymology*; D054876:Prenylation; D027821:Rutaceae / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D047188:Chalcones; D004791:Enzyme Inhibitors; C015812:dihydrochalcone