[Patient awakening from anesthesia was re-sedated by administration of flumazenil].
An 83-year-old female patient was managed in intensive care unit postoperatively with artificial ventilation and propofol-based sedation. On the second postoperative day, we tried to remove an endotracheal tube. Naloxone was administered to the patient for reversing the sedative effect of fentanyl infused intraoperatively. Her consciousness level was improved; however, subsequent administration of flumazenil induced hypnosis. Benzodiazepine-like partial agonistic effect of flumazenil might have enhanced residual hypnotic effect of propofol. Administration of flumazenil to the patient infused with propofol should be done cautiously for awakening the patient from anesthesia.
Adachi
Yushi
Y
Intensive Care Unit of University Hospital, Hamamatsu University School of Medicine, Hamamatsu 431-3192.
Suzuki
Katsumi
K
Obata
Yukako
Y
Doi
Matsuyuki
M
Sato
Shigehito
S
D000369:Aged, 80 and over; D000762:Anesthesia Recovery Period; D004357:Drug Synergism; D005260:Female; D005442:Flumazenil / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000097:blood; D008874:Midazolam / Q000037:antagonists & inhibitors; D015742:Propofol / Q000008:administration & dosage / Q000097:blood
D006993:Hypnotics and Sedatives; D005442:Flumazenil; D008874:Midazolam; D015742:Propofol