title: Triglyceride response following an oral fat tolerance test in Burmese cats, other pedigree cats and domestic crossbred cats.
abstract: Primary lipid disorders causing fasting triglyceridaemia have been documented infrequently in Burmese cats. Due to the known increased risk of diabetes mellitus and sporadic reports of lipid aqueous in this breed, the aim of this study was to determine whether healthy Burmese cats displayed a more pronounced pre- or post-prandial triglyceridaemia compared to other cats. Serum triglyceride (TG) concentrations were determined at baseline and variably at 2, 4 and 6h after ingestion of a high-fat meal (ie, an oral fat tolerance test) in a representative sample of Burmese and non-Burmese cats. The median 4 and 6h serum TG concentrations were significantly higher in Burmese cats (4h - 2.8mmol/l; 6h - 8.2mmol/l) than in other pedigree and domestic crossbred cats (4h - 1.5mmol/l; 6h - 1.0mmol/l). The non-Burmese group had post-prandial TG concentrations ranging from 0.6 to 3.9mmol/l. Seven Burmese cats had post-prandial TG concentrations between 6.6 and 19.0mmol/l, five had concentrations between 4.2 and 4.7mmol/l, while the remaining 15 had post-prandial concentrations between 0.5 and 2.8mmol/l. None of these Burmese cats had fasting triglyceridaemia. Most Burmese cats with a 4 h TG > 6.0 mmol/l had elevated fasting very low density lipoprotein (VLDL) concentrations. This study demonstrates that a proportion of Burmese cats in Australia have delayed TG clearance compared to other cats. The potential repercussions of this observation with reference to lipid aqueous, pancreatitis and diabetes mellitus in Burmese cats are discussed.
authors.affiliation: Faculty of Veterinary Science, The University of Sydney, NSW 2006, Australia. ekluger@hotmail.com
authors.forename: Elissa K
authors.initials: EK
authors.lastname: Kluger
authors.forename: Chloë
authors.initials: C
authors.lastname: Hardman
authors.forename: Merran
authors.initials: M
authors.lastname: Govendir
authors.forename: Randolph M
authors.initials: RM
authors.lastname: Baral
authors.forename: David R
authors.initials: DR
authors.lastname: Sullivan
authors.forename: David
authors.initials: D
authors.lastname: Snow
authors.forename: Richard
authors.initials: R
authors.lastname: Malik
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001947:Breeding; D002371:Cat Diseases / Q000097:blood* / Q000235:genetics; D002415:Cats; D004041:Dietary Fats / Q000008:administration & dosage*; D004586:Electrophoresis / Q000662:veterinary; D005128:Eye Diseases / Q000235:genetics / Q000662:veterinary; D005215:Fasting / Q000097:blood; D005260:Female; D015228:Hypertriglyceridemia / Q000097:blood / Q000235:genetics / Q000662:veterinary*; D050356:Lipid Metabolism / Q000235:genetics; D008297:Male; D009517:New South Wales; D014280:Triglycerides / Q000097:blood*
chemical_list: D004041:Dietary Fats; D014280:Triglycerides