title: New insights into the mechanisms of action of radioimmunotherapy in lymphoma.
abstract: The exquisite sensitivity of haematological malignancies to targeted radiation alongside the impressive results achieved by the pioneers in this field suggests that radioimmunotherapy is likely to be a productive area for future clinical research. Recent experimental work has demonstrated that the combination of targeted radiation and antibody effector mechanisms are critical to long-term clearance of tumour. This review provides the background of clinical and biological insights into the mechanisms of action of radioimmunotherapy.
authors.affiliation: School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.
authors.forename: Andrei
authors.initials: A
authors.lastname: Ivanov
authors.forename: Ruth
authors.initials: R
authors.lastname: Swann
authors.forename: Tim
authors.initials: T
authors.lastname: Illidge
mesh_terms: D000465:Algorithms; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003663:Decision Trees; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008223:Lymphoma / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy*; D016499:Radioimmunotherapy / Q000379:methods; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D019275:Radiopharmaceuticals