Interplay between a phase response curve and spike-timing-dependent plasticity leading to wireless clustering.
A phase response curve (PRC) characterizes the signal transduction between oscillators such as neurons on a fixed network in a minimal manner, while spike-timing-dependent plasiticity (STDP) characterizes the way of rewiring networks in an activity-dependent manner. This paper demonstrates that these two key properties both related to the interaction times of oscillators work synergetically to carve functionally useful circuits. STDP working on neurons that prefer asynchrony converts the initial asynchronous firing to clustered firing with synchrony within a cluster. They get synchronized within a cluster despite their preference to asynchrony because STDP selectively disrupts intracluster connections, which we call wireless clustering. Our PRC analysis reveals a triad mechanism: the network structure affects how the PRC is read out to determine the synchrony tendency, the synchrony tendency affects how the STDP works, and STDP affects the network structure, closing the loop.
Câteau
Hideyuki
H
Laboratory for Neural Circut Theory, RIKEN Brain Science Institute, 2-1 Hirowasa, Wako, Saitama 351-0198, Japan.
Kitano
Katsunori
K
Fukai
Tomoki
T
D000200:Action Potentials / Q000502:physiology*; D001683:Biological Clocks / Q000502:physiology*; D016000:Cluster Analysis; D003198:Computer Simulation; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013223:Statistics as Topic; D009435:Synaptic Transmission / Q000502:physiology