The complement system in the peripheral nerve: friend or foe?
The complement (C) system plays a central role in innate immunity and bridges innate and adaptive immune responses. A fine balance of C activation and regulation mediates the elimination of invading pathogens and the protection of the host from excessive C deposition on healthy tissues. If this delicate balance is disrupted, the C system may cause injury and contribute to the pathogenesis of various diseases, including neuropathies. Here we review evidence indicating that C factors and regulators are locally synthesized in the peripheral nerve and we discuss the evidence supporting the protective or detrimental role of C activation in health, injury and disease of the peripheral nerve.
Ramaglia
V
V
Neurogenetics Laboratory, University of Amsterdam, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.
Daha
M R
MR
Baas
F
F
D000818:Animals; D003167:Complement Activation / Q000276:immunology*; D003165:Complement System Proteins / Q000096:biosynthesis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology; D009416:Nerve Regeneration / Q000276:immunology; D010525:Peripheral Nerves / Q000276:immunology*; D017933:Peripheral Nervous System / Q000276:immunology; D010523:Peripheral Nervous System Diseases / Q000276:immunology
D003165:Complement System Proteins