title: Impact of shielding parenteral nutrition from light on routine monitoring of blood glucose and triglyceride levels in preterm neonates.
abstract: BACKGROUND
  Premature infants are vulnerable to complications related to oxidative stress. Exposure to light increases oxidation products in solutions of total parenteral nutrition (TPN) such as lipid peroxides and hydrogen peroxide. Oxidative stress impairs glucose uptake and affects lipid metabolism.
  
  
  OBJECTIVE
  products of photo-oxidation contaminating TPN affect lipid metabolism.
  
  
  OBJECTIVE
  Evaluate the effect of photoprotection of TPN in preterm infants on plasma glucose and triglyceride (TG) concentrations.
  
  
  METHODS
  Secondary analysis of a prospective study allocating preterm infants to light-exposed (LE, n = 32) or light-protected (LP, n = 27) TPN.
  
  
  METHODS
  Level III NICU referral centre for patients of British Columbia.
  
  
  METHODS
  Preterm infants requiring TPN.
  
  
  METHODS
  TG and blood glucose measured during routine monitoring while on full TPN were compared between LE and LP.
  
  
  RESULTS
  Clinical characteristics were similar between the two groups (gestational age 28+/-1 wk; birth weight: 1.0+/-0.1 kg). Nutrient intakes from TPN and from minimal enteral nutrition were comparable between LE and LP. Blood glucose was higher in preterm infants receiving LE (p<0.001). The accumulation of TG with increasing lipid intake was twice as high with LE accounting for significantly higher TG levels on days 8 and 9 (p<0.05).
  
  
  CONCLUSIONS
  Failure to photoprotect TPN may cause alterations in intermediary metabolism. Shielding TPN from light provides a potential benefit for preterm infants by avoiding hypertriglyceridaemia allowing for increased substrate delivery.
authors.affiliation: Division of Neonatology, Children's and Women's Health Centre of British Columbia, 4480 Oak Street, Vancouver, BC, Canada.
authors.forename: Minesh
authors.initials: M
authors.lastname: Khashu
authors.forename: Adele
authors.initials: A
authors.lastname: Harrison
authors.forename: Vikki
authors.initials: V
authors.lastname: Lalari
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Lavoie
authors.forename: Philippe
authors.initials: P
authors.lastname: Chessex
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008027:Light / Q000009:adverse effects*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D010289:Parenteral Nutrition, Total / Q000379:methods*; D019999:Pharmaceutical Solutions / Q000528:radiation effects; D011446:Prospective Studies; D011835:Radiation Protection / Q000379:methods; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D019999:Pharmaceutical Solutions; D014280:Triglycerides