Factors associated with fatigue, sleep, and cognitive function among patients with head and neck cancer.
BACKGROUND
Fatigue, sleep disturbances, and cognitive impairment are prevalent and clinically important problems among head and neck cancer patients. Our study aim was to determine the most important correlates of these problems among patients with head and neck cancer.


METHODS
A cross-sectional, self-administered survey was completed by 58 (response rate 79%) patients with head and neck cancer in an academic oncology clinic.


RESULTS
Multiple linear-regression analyses demonstrated that fatigue was associated with younger age (beta=-0.22), previous radiation therapy (beta=0.23), fewer months since cancer diagnosis (beta=-0.25), and depression (beta=0.40). Sleep dysfunction was associated with younger age (beta=-0.31) and higher symptom index (beta=0.39). Cognitive dysfunction was associated with higher symptom index only (beta=-0.49).


CONCLUSIONS
Younger age, previous radiation, more recent cancer diagnosis, depression, and more severe symptoms may be associated with fatigue, sleep, and/or cognitive dysfunction. These results suggest at-risk subgroups warranting more aggressive screening and potentially supportive care interventions.
Rogers
Laura Q
LQ
Department of Medicine, SIU School of Medicine, Springfield, Illinois, USA. lrogers@siumed.edu
Courneya
Kerry S
KS
Robbins
K Thomas
KT
Rao
Krishna
K
Malone
James
J
Seiz
Alison
A
Reminger
Sheryl
S
Markwell
Stephen J
SJ
Burra
Vishal
V
D000367:Age Factors; D000368:Aged; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology* / Q000523:psychology; D003430:Cross-Sectional Studies; D005221:Fatigue / Q000453:epidemiology / Q000209:etiology* / Q000523:psychology; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000523:psychology; D006801:Humans; D007087:Illinois / Q000453:epidemiology; D008019:Life Style; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection / Q000523:psychology; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D018714:Radiotherapy, Adjuvant / Q000523:psychology; D012307:Risk Factors; D018434:Sickness Impact Profile; D012893:Sleep Wake Disorders / Q000453:epidemiology / Q000209:etiology* / Q000523:psychology; D011795:Surveys and Questionnaires; D013997:Time Factors