Altered bone remodeling in psoriatic arthritis.
Bone is a highly dynamic organ that interacts with a wide array of cells and tissues. Recent studies have unveiled unanticipated connections between the immune and skeletal systems, and this relationship led to the development of a new field called osteoimmunology. This field will enable investigators to translate basic science findings in bone biology to clinical applications for inflammatory joint diseases such as psoriatic arthritis (PsA). This review examines the disruption of bone homeostasis in PsA and discusses the pivotal role of osteoclasts, osteoblasts, and signaling pathways in the altered remodeling observed in this inflammatory arthritis. It also discusses the effects of tumor necrosis factor inhibition on bone resorption and new bone formation in PsA.
Mensah
Kofi A
KA
Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA. edward_schwarz@urmc.rochester.edu
Schwarz
Edward M
EM
Ritchlin
Christopher T
CT
D015535:Arthritis, Psoriatic / Q000188:drug therapy / Q000503:physiopathology*; D001862:Bone Resorption / Q000503:physiopathology*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000502:physiology*
C501126:DKK1 protein, human; D007155:Immunologic Factors; D036341:Intercellular Signaling Peptides and Proteins; D014409:Tumor Necrosis Factor-alpha