title: Prolactin evokes lactational transmission of larvae in mice infected with Toxocara canis.
abstract: We investigated the trans-lactational maternal-neonatal transmission of Toxocara canis larvae in mice, with particular interest in the role of prolactin in their migration to the mammary gland. Two female mice were infected with 300 T. canis eggs soon after delivery of 27 offspring. After 1 week of breast-feeding, seven larvae were recovered from 4 of 13 offspring. After 2 weeks of lactation, 101 larvae were recovered from all the remaining offspring. Daily prolactin administration (5 microg) was performed 2 weeks before T. canis infection and continued until 2 weeks after infection in six non-pregnant female mice, which resulted in larval accumulation in the mammary gland. Furthermore, prolactin administration in female mice that had been infected with T. canis 4 weeks prior to prolactin treatment induced migration of larvae into the mammary gland. These findings suggest that prolactin is a promoting factor contributing to lactational transmission of T. canis larvae in mice.
authors.affiliation: Section of Environmental Parasitology, Graduate School of Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
authors.forename: Zongfan
authors.initials: Z
authors.lastname: Jin
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Akao
authors.forename: Nobuo
authors.initials: N
authors.lastname: Ohta
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D005260:Female; D018445:Infectious Disease Transmission, Vertical; D007774:Lactation / Q000502:physiology*; D007814:Larva / Q000502:physiology; D008321:Mammary Glands, Animal / Q000469:parasitology* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D011388:Prolactin / Q000008:administration & dosage / Q000494:pharmacology*; D017166:Toxocara canis / Q000254:growth & development / Q000472:pathogenicity / Q000502:physiology*; D014120:Toxocariasis / Q000469:parasitology / Q000635:transmission*
chemical_list: D011388:Prolactin