title: The metalloproteinase-disintegrin ADAM10 is exclusively expressed by type I muscle fibers.
abstract: ADAM10 (Kuzbanian) is a member of a recently discovered family of membrane-anchored metalloproteinases with a complex and conserved domain structure. In part, these metalloproteinases have been implicated in muscle formation. Herein the expression pattern of ADAM10 in human skeletal muscle was studied. ADAM10 was found to be present in human myoblasts and to be exclusively expressed in type I fibers, suggesting that it may be critical in muscle fiber differentiation.
authors.affiliation: Department of Neurology, Heinrich Heine University, Moorenstrasse 5, Düsseldorf, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Dehmel
authors.forename: Hans Hilmar
authors.initials: HH
authors.lastname: Goebel
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Hartung
authors.forename: Helmar
authors.initials: H
authors.lastname: Lehmann
authors.forename: Heinz
authors.initials: H
authors.lastname: Wiendl
authors.forename: Bernd C
authors.initials: BC
authors.lastname: Kieseier
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism*; D000072197:ADAM10 Protein; D000251:Adenosine Triphosphatases / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D018657:Muscle Fibers, Slow-Twitch / Q000378:metabolism*; D018995:Myosin Heavy Chains / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; D053829:Amyloid Precursor Protein Secretases; D051722:ADAM Proteins; D000072197:ADAM10 Protein; C491236:ADAM10 protein, human; D000251:Adenosine Triphosphatases; D018995:Myosin Heavy Chains