Serum levels of adenosine deaminase and pregnancy-related hormones in hyperemesis gravidarum.
OBJECTIVE
We investigated the correlation between pregnancy-related hormones and serum adenosine deaminase (indicator of cellular immunity) level in women with hyperemesis gravidarum.


METHODS
Twenty patients with hyperemesis gravidarum and 20 normal pregnancies were included in this prospective, case-control study. Serum adenosine deaminase levels, hematological parameters (white blood cells, neutrophil, monocyte and lymphocyte counts) and hormone levels (prolactin, progesterone, thyroid stimulating hormone, human chorionic gonadotropin beta subunit, estradiol (E2)) were measured in all women. Interrelations of blood cell counts and hormone levels with serum adenosine deaminase levels were also investigated.


RESULTS
Serum adenosine deaminase, human chorionic gonadotropin beta subunit, thyroid stimulating hormone, E2, progesterone and prolactin levels, and lymphocyte and monocyte counts in women with hyperemesis gravidarum were significantly higher than in controls but white blood cells, neutrophil, T3 and T4 levels were not different. Serum adenosine deaminase level correlated with E2, progesterone, lymphocyte, and monocyte levels for all patients.


CONCLUSIONS
Elevated serum adenosine deaminase in patients with hyperemesis gravidarum may relate to high levels of E2 and progesterone.
Taşkin
Salih
S
Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey. salihtaskin@yahoo.com
Taşkin
Elif Aylin
EA
Seval
Mehmet Murat
MM
Atabekoğlu
Cem Somer
CS
Berker
Bulent
B
Söylemez
Feride
F
D000243:Adenosine Deaminase / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood* / Q000276:immunology; D007111:Immunity, Cellular; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D055815:Young Adult
D018997:Chorionic Gonadotropin, beta Subunit, Human; D011374:Progesterone; D004958:Estradiol; D000243:Adenosine Deaminase