title: Chlorine dioxide and chlorhexidine mouthrinses compared in a 3-day plaque accumulation model.
abstract: BACKGROUND
  The aim of this study was to investigate the inhibiting effect of a chlorine dioxide mouthrinse as opposed to a mouthrinse containing chlorhexidine (0.20%) during 3 days of plaque accumulation.
  
  
  METHODS
  At baseline, all participants (N=77) received a professional prophylaxis and were randomly assigned to the test (chlorine dioxide) or (positive) control (chlorhexidine) group. On the following 3 days, both groups rinsed twice daily for 1 minute with 10 ml test or control solution. At the end of the experimental period, plaque was assessed, and the panelists filled out a questionnaire.
  
  
  RESULTS
  Chlorhexidine inhibited plaque growth significantly more than the mouthrinse containing chlorine dioxide (plaque index=1.39 versus 1.96, respectively; P<0.001). The results of the questionnaire showed that the panelists found chlorhexidine easier to use and more effective. However, they preferred the taste of the chlorine dioxide mouthrinse and experienced less taste alterations.
  
  
  CONCLUSIONS
  Chlorine dioxide mouthrinse seems to be a less potent plaque inhibitor than chlorhexidine.
authors.affiliation: Department of Periodontology, Academic Center for Dentistry Amsterdam, Amsterdam, The Netherlands. s.paraskevas@acta.nl
authors.forename: Spiros
authors.initials: S
authors.lastname: Paraskevas
authors.forename: Nanning A M
authors.initials: NA
authors.lastname: Rosema
authors.forename: Paula
authors.initials: P
authors.lastname: Versteeg
authors.forename: Ubele
authors.initials: U
authors.lastname: Van der Velden
authors.forename: G A
authors.initials: GA
authors.lastname: Van der Weijden
mesh_terms: D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000627:therapeutic use*; D017606:Chlorine Compounds / Q000627:therapeutic use*; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D010087:Oxides / Q000627:therapeutic use*; D017060:Patient Satisfaction; D016037:Single-Blind Method; D013649:Taste / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D017606:Chlorine Compounds; D009067:Mouthwashes; D010087:Oxides; C025109:chlorine dioxide; D002710:Chlorhexidine