Dysregulation of matrix metalloproteinases and their tissue inhibitors by S100A4.
The S100A4 protein as well as the matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are associated with diseases such as arthritis and cancer. This mini review focuses on in vitro and in vivo studies indicating S100A4 involvement in regulation of MMPs and TIMPs, and the biological and pathobiological consequences of this regulation.
Elenjord
Renate
R
Department of Pharmacy, University of Tromsø, Tromsø, Norway. renate.elenjord@farmasi.uit.no
Ljones
Hilde
H
Sundkvist
Elisabeth
E
Loennechen
Thrina
T
Winberg
Jan Olof
JO
D000818:Animals; D015536:Down-Regulation; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins / Q000378:metabolism*; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism*; D015854:Up-Regulation
D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins; D019714:Tissue Inhibitor of Metalloproteinases; C077591:S100A4 protein, human; D020782:Matrix Metalloproteinases