title: Characterization of hepatocellular carcinoma and colorectal liver metastasis by means of perfusion MRI.
abstract: OBJECTIVE
  To characterize and compare hepatocellular carcinoma and liver metastases of colorectal metastatic cancer (CMC) by means of quantitative liver perfusion MRI.
  
  
  METHODS
  Liver perfusion was assessed in 26 HCC and CMC patients (50 nodules) by means of contrast-enhanced MRI. Six perfusion parameters-hepatic perfusion index (HPI), mean transit time (MTT), distribution volume (DV), total blood flow (F(T)), arterial blood flow (F(A)), and portal blood flow (F(P))-were calculated in tumor nodules and the adjacent hepatic parenchyma.
  
  
  RESULTS
  The values of F(T), F(A), F(P), and DV were significantly higher in the HCC than in the CMC group, whereas MTT was significantly higher in the CMC group. There was no significant difference in HPI. Arterial blood flow was higher than portal blood flow in the CMC group, while portal blood flow was slightly higher than arterial blood flow in the HCC group.
  
  
  CONCLUSIONS
  The present work describes the use of dynamic MRI to quantitatively assess liver perfusion, which in the future may help studying liver cancers on the basis of their microvascular characteristics.
authors.affiliation: Department of General Surgery and Liver Transplantation, La Croix Rousse Teaching Hospital, Lyon, France.
authors.forename: Siraj Saadaldin
authors.initials: SS
authors.lastname: Abdullah
authors.forename: Jean Baptiste
authors.initials: JB
authors.lastname: Pialat
authors.forename: Marlene
authors.initials: M
authors.lastname: Wiart
authors.forename: François
authors.initials: F
authors.lastname: Duboeuf
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Mabrut
authors.forename: Brigitte
authors.initials: B
authors.lastname: Bancel
authors.forename: Agnès
authors.initials: A
authors.lastname: Rode
authors.forename: Christian
authors.initials: C
authors.lastname: Ducerf
authors.forename: Jacques
authors.initials: J
authors.lastname: Baulieux
authors.forename: Yves
authors.initials: Y
authors.lastname: Berthezene
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008113:Liver Neoplasms / Q000098:blood supply / Q000556:secondary*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D009942:Organometallic Compounds; D018709:Statistics, Nonparametric
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine