title: [Orbitofrontal dysfunction in multiple sclerosis: Iowa Gambling Task].
abstract: Cognitive dysfunction has been widely studied in multiple sclerosis (MS), however decision-making has been less investigated. The current study examined the decision-making processes of patients with multiple sclerosis (MS) using a computerized version of the Iowa Gambling Task (IGT). This task was applied to 18 patients with clinically diagnosed MS and 18 healthy control subjects matched for age, sex, and years of education. The results showed that IGT scores differ significantly between patients with MS and the healthy control subjects: the patients with MS made significantly less advantageous decisions than the controls in the IGT. Possible causes of impaired decision-making in multiple sclerosis are discussed.
authors.affiliation: Institut Universitari de Neurorehabilitació Guttmann, Universidad Autónoma de Barcelona, Badalona, Spain. agarciam.investigacio@guttmann.com
authors.forename: Alberto
authors.initials: A
authors.lastname: García-Molina
authors.forename: Pablo
authors.initials: P
authors.lastname: Rodríguez Rajo
authors.forename: Pere
authors.initials: P
authors.lastname: Vendrell Gómez
authors.forename: Carme
authors.initials: C
authors.lastname: Junqué i Plaja
authors.forename: Teresa
authors.initials: T
authors.lastname: Roig-Rovira
mesh_terms: D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005715:Gambling; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000473:pathology*; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000473:pathology* / Q000503:physiopathology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires