title: Severe everolimus-associated pneumonitis in a renal transplant recipient.
abstract: Inhibitors of mTOR (mammalian target of rapamycin) are immunosuppressants with less nephrotoxic potential than calcineurin inhibitors and antiproliferative effects, which are advantageous in the case of malignancy. However, a series of adverse events has been reported with the first-generation mTOR inhibitor sirolimus that includes hypersensitivity-like interstitial pneumonitis. To our knowledge, only one case of a pneumonitis associated with everolimus in a heart transplant patient has been reported, and it was related to elevated trough blood levels. We report herein the first case of a kidney graft recipient who developed everolimus-associated pneumonitis with normal trough blood levels that was completely reversed after drug withdrawal.
authors.affiliation: Nephrology Unit, Fundación Jiménez Díaz-Capio, Av Reyes Catolicos 2, 28040 Madrid, Spain. salexandru@fjd.es
authors.forename: Simona
authors.initials: S
authors.lastname: Alexandru
authors.forename: Alberto
authors.initials: A
authors.lastname: Ortiz
authors.forename: Sonia
authors.initials: S
authors.lastname: Baldovi
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Milicua
authors.forename: Elena
authors.initials: E
authors.lastname: Ruíz-Escribano
authors.forename: Jesús
authors.initials: J
authors.lastname: Egido
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Plaza
mesh_terms: D000068338:Everolimus; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011494:Protein Kinases / Q000187:drug effects; D011859:Radiography; D020123:Sirolimus / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood; D058570:TOR Serine-Threonine Kinases
chemical_list: D007166:Immunosuppressive Agents; D000068338:Everolimus; D011494:Protein Kinases; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus