title: Pulmonary hypertension associated with lung transplantation obliterative bronchiolitis and vascular remodeling of the allograft.
abstract: Pathologic obliterative bronchiolitis (OB)/Bronchiolitis obliterans syndrome (pathologic OB/BOS) is the major obstacle to long-term survival post-lung transplantation (LT). Our group has demonstrated that pulmonary hypertension (PH) complicates the course of chronic inflammatory lung diseases that have similarities to pathologic OB/BOS and that vascular remodeling of the bronchial circulation occurs during BOS. Consequently, we hypothesized that PH is associated with pathologic OB/BOS and may result from a vasculopathy of the allograft pulmonary circulation. We conducted a single-center, retrospective study and examined the presence of PH and vasculopathy in patients with pathologic OB/BOS. Fifty-two pathologic specimens post-LT were recovered from January 10, 1997 to January 5, 2007 and divided into two groups, those with and without pathologic OB/BOS.PH was defined as a mean pulmonary artery pressure (mPAP) > 25 mmHg by right heart catheterization (RHC) or right ventricular systolic pressure (RVSP) > or = 45 mmHg by transthoracic echocardiogram (TTE). PH was more prevalent in those LT recipients with pathologic OB/BOS (72% vs. 0%, p = 0.003). Furthermore, pulmonary arteriopathy and venopathy were more prevalent in patients with pathologic OB/BOS (84% vs. 4%, p < 0.0001, and 77% vs. 35%, p = 0.004, respectively). PH is common in LT recipients with pathologic OB/BOS and is associated with a vasculopathy of the allograft pulmonary circulation.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. rsaggar@mednet.ucla.edu
authors.forename: R
authors.initials: R
authors.lastname: Saggar
authors.forename: D J
authors.initials: DJ
authors.lastname: Ross
authors.forename: R
authors.initials: R
authors.lastname: Saggar
authors.forename: D A
authors.initials: DA
authors.lastname: Zisman
authors.forename: A
authors.initials: A
authors.lastname: Gregson
authors.forename: J P
authors.initials: JP
authors.lastname: Lynch
authors.forename: M P
authors.initials: MP
authors.lastname: Keane
authors.forename: S Samuel
authors.initials: SS
authors.lastname: Weigt
authors.forename: A
authors.initials: A
authors.lastname: Ardehali
authors.forename: B
authors.initials: B
authors.lastname: Kubak
authors.forename: C
authors.initials: C
authors.lastname: Lai
authors.forename: D
authors.initials: D
authors.lastname: Elashoff
authors.forename: M C
authors.initials: MC
authors.lastname: Fishbein
authors.forename: W D
authors.initials: WD
authors.lastname: Wallace
authors.forename: J A
authors.initials: JA
authors.lastname: Belperio
mesh_terms: D000328:Adult; D001808:Blood Vessels / Q000473:pathology* / Q000503:physiopathology; D001989:Bronchiolitis Obliterans / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications* / Q000503:physiopathology; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014184:Transplantation, Homologous / Q000009:adverse effects; D019737:Transplants / Q000009:adverse effects