title: Establishment and characterization of a human cell line derived from a uterine papillary serous carcinoma with wild-type p53 function.
abstract: Uterine papillary serous carcinoma is an uncommon histologic subtype of endometrial cancer that behaves aggressively and has a poor prognosis. We successfully established a uterine papillary serous carcinoma cell line. The population-doubling time was approximately 16 h. Although loss of p53 function is considered critical for the molecular pathogenesis of uterine papillary serous carcinoma, p53 was not only mutated but functionally active in this cell line. This newly established cell line should be useful for investigating the characteristics of uterine papillary serous carcinoma.
authors.affiliation: Department of Translational Research, Ehime University School of Medicine, Toon, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Atsumi
authors.initials: A
authors.lastname: Kojima
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Sudo
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Ohki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Mikami
authors.forename: Masaharu
authors.initials: M
authors.lastname: Ito
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Nishimura
mesh_terms: D000368:Aged; D000818:Animals; D002455:Cell Division; D045744:Cell Line, Tumor; D018283:Cystadenocarcinoma, Papillary / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D007621:Karyotyping; D051379:Mice; D008819:Mice, Nude; D009154:Mutation; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000502:physiology*; D014594:Uterine Neoplasms / Q000235:genetics / Q000473:pathology
chemical_list: D016159:Tumor Suppressor Protein p53