Organometallic-polypeptide block copolymers: synthesis and self-assembly of poly(ferrocenyldimethylsilane)-b-poly(epsilon-benzyloxycarbonyl-L-lysine).
A new type of metallopolymer-polypeptide block copolymer poly(ferrocenyldimethylsilane)-b-poly (epsilon-benzyloxycarbonyl-L-lysine) was synthesized by ring-opening polymerization of epsilon-benzyloxycarbonyl-L-lysine N-carboxyanhydride initiated by using a primary amino-terminated poly(ferrocenyldimethylsilane). Studies on the self-organization behavior of this polypeptide block copolymer in both the bulk state and in solution were performed. In the bulk state, a cylindrical-in-lamellar structure was observed in a compositionally asymmetric sample. Rod-like micelles with a polyferrocenylsilane core formed in a polypeptide-selective solvent alone or in the presence of a common solvent. Significantly, an additional small quantity of the common solvent assisted the formation of longer micelles and micelles with better shape-regularity. This is attributed to a decrease in the number of nucleation events and PFS core reorganization effects.
Wang
Yishan
Y
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada.
Zou
Shan
S
Kim
Kyoung Taek
KT
Manners
Ian
I
Winnik
Mitchell A
MA
D002850:Chromatography, Gel; D005296:Ferrous Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D009942:Organometallic Compounds / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011107:Polylysine / Q000031:analogs & derivatives* / Q000737:chemistry; D012833:Siloxanes / Q000737:chemistry*
D005296:Ferrous Compounds; D009942:Organometallic Compounds; D010455:Peptides; D012833:Siloxanes; C509667:poly(ferrocenyldimethylsilane-b-dimethylsiloxane); D011107:Polylysine; C038295:poly(N(epsilon)-benzyloxycarbonyl-L-lysine)