Intracellular antigens released from Balb/c mice kidneys under chemically induced apoptosis and/or necrosis.
The present investigation assesses the possible role of apoptosis and necrosis in intracellular antigen exposure of kidneys from Balb/c mice. Renal tissues were cultured and treated with chemicals to induce apoptosis and /or necrosis. The expression of intracellular antigens Sm, RNP, Ro and La were monitored with antibodies against these antigens. Main results confirm that renal intracellular antigens are released and exposed onto the surface of apoptotic and necrotic cells, therefore these antigens become an easy target of autoantibodies. This mechanism may be important in the lupus nephritis pathogenesis.
Ramírez-Sandoval
R
R
Department of Immunology, CBE, Universidad Autonoma de Zacatecas, Mexico.
Vazquez-del-Mercado
M
M
Daneri-Navarro
A
A
López-Robles
E
E
Bollain-y-Goitia
J J
JJ
Avalos-Diaz
E
E
Herrera-Esparza
R
R
D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000187:drug effects; D001324:Autoantigens / Q000096:biosynthesis*; D007668:Kidney / Q000276:immunology* / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009336:Necrosis / Q000139:chemically induced; D012261:Ribonucleoproteins / Q000378:metabolism*; D017411:Ribonucleoproteins, Small Nuclear / Q000378:metabolism*; D046509:Tissue Culture Techniques; D055517:snRNP Core Proteins; D000097585:SS-B Antigen; D000099207:SS-A Antigen
D001324:Autoantigens; D012261:Ribonucleoproteins; D017411:Ribonucleoproteins, Small Nuclear; D055517:snRNP Core Proteins; D000097585:SS-B Antigen; D000099207:SS-A Antigen