[The study of ovarian autoimmunity and ovarian reserve in women with uncertain sterility].
Ovarian autoimmunity can be induce ovarian function, which is shown clinically with premature ovarian failure, unknown sterility and unsuccessful in vitro fertilizations. Antiovarian antibodies are directed to antigens functional zones of zona pellucida and granulose cells with important part in follicle genesis and fertilization.


OBJECTIVE
We have to investigate the influence of ovarian autoimmunity, antiovarian and antizona pellucida antibodies on endocrinology markers of ovarian reserve: inhibin B, FSH, LH by the women with unknown sterility.


METHODS
340 women were investigated with unknown sterility and 60 women were investigated with only one successful pregnancy at least. We investigated them for presence of antiovarian antibodies, antizona pellucida antibodies, and of course the levels of FSH, LH, inhibin B on the third day of menstrual cycle. Serological methods were used: ELISA- biochemical technique to detect the presence of antiovarian antibodies and antizona pellucida antibodies, inhibin B, FSH, LH. Statistical methods for analysis were also used.


RESULTS
In investigated group was found the presence of antiovarian antibodies in 58 women (17.05%) and in control group was not found. Antizona pellucida antibodies presence was found in 43 women (12.64%) in investigated group and in control found was not found. It was not found important difference in levels of FSH, LH, inhibin B on the third day of menstrual cycle between women with and women without antiovarian antibodies.


CONCLUSIONS
Antiovarian antibodies were observed only in women who have had laparoscopic ovarian drilling. The frequency of antiovarian antibodies among the Bulgarian women with unknown sterility is 17.05%. The presence of antiovarian antibodies is not associated with poor ovarian reserve as we investigated the levels of FSH, LH, inhibin B on the third day of the menstrual cycle.
Emin
A
A
Konova
E
E
Lichev
D
D
Aĭvazova
N
N
Popov
I
I
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D015551:Autoimmunity / Q000276:immunology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D010053:Ovary / Q000276:immunology / Q000502:physiology; D015044:Zona Pellucida / Q000276:immunology / Q000502:physiology
D001323:Autoantibodies