title: Ligasure versus Ultracision in thyroid surgery: a prospective randomized study.
abstract: OBJECTIVE
  New hemostatic technologies (NT) are often employed in thyroid surgery in the effort to reduce operating time and complications. The aim of this study is to compare three different hemostatic techniques.
  
  
  METHODS
  This is a prospective randomized study. There were 150 patients, aged 56 +/- 14 years, randomized for total thyroidectomy with conventional technique (CT), Ligasure vessel sealing system (LI) or Harmonic Scalpel (HS) at the university surgical department. One hundred thirty-five patients had benign diseases; 15 had malignancies.
  
  
  RESULTS
  Mean postoperative hospital stay was 2.6 days. Mean operation time was 113 +/- 31 min; in HS patients, it was significantly shorter (p < 0.001). Morbidity was 43.3%; mortality was nil. Morbidity was significantly different between CT and NT groups (p = 0.0002); HS and LI groups had a higher morbidity (p = 0.0001 and p = 0.02, respectively). Mean postoperative calcemia was 1.12 +/- 0.1 mmol/l with a significant difference between groups; NT patients had a significantly lower calcemia (p < 0.05). There was no difference in recurrent laryngeal nerve palsies and in intraoperative blood losses (p = ns).
  
  
  CONCLUSIONS
  According to our experience, the only real advantage of new hemostatic technologies was a shorter operation time with HS.
authors.affiliation: Surgical Department, S. Gerardo Hospital, University of Milan Bicocca, Via Pergolesi 33, 20052, Monza, Italy. srtpvn@gmail.com
authors.forename: Paola Vincenza
authors.initials: PV
authors.lastname: Sartori
authors.forename: Sergio
authors.initials: S
authors.lastname: De Fina
authors.forename: Giovanni
authors.initials: G
authors.lastname: Colombo
authors.forename: Francesco
authors.initials: F
authors.lastname: Pugliese
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Romano
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cesana
authors.forename: Franco
authors.initials: F
authors.lastname: Uggeri
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006488:Hemostasis, Surgical / Q000295:instrumentation*; D006801:Humans; D006996:Hypocalcemia / Q000209:etiology; D008026:Ligation / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology*; D013525:Surgical Instruments; D013536:Suture Techniques; D013959:Thyroid Diseases / Q000601:surgery*; D013964:Thyroid Neoplasms / Q000601:surgery*; D013965:Thyroidectomy / Q000295:instrumentation*; D014464:Ultrasonic Therapy / Q000295:instrumentation*; D014826:Vocal Cord Paralysis