title: 5-HT(2A) inverse-agonists for the treatment of insomnia.
abstract: Nearly one half of the adult population in the U.S. experience some symptoms of insomnia (difficulties with getting to sleep, maintaining sleep, and/or sleep quality) on a weekly basis. Although most people with insomnia complain primarily of issues related to sleep maintenance and quality, current therapeutic approaches, including GABA(A) agonists, off label antidepressant use, H(1) antagonists and melatonin agonists, primarily address sleep onset latency. The overall sleep architecture, especially that of the deeper stages of NREM sleep known as slow wave sleep (SWS), plays a crucial role in restorative, restful sleep. Through the 5-HT(2A) receptor, serotonin plays an active role in the regulation of sleep architecture. Antagonists / inverse-agonists of 5-HT(2A), such as APD125, volinanserin, eplivanserin, pruvanserin and pimavanserin, are currently being investigated as therapeutics that could improve the treatment of sleep maintenance and quality in people with insomnia.
authors.affiliation: Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA. bteegarden@arenapharm.com
authors.forename: Bradley R
authors.initials: BR
authors.lastname: Teegarden
authors.forename: Hussien
authors.initials: H
authors.lastname: Al Shamma
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Xiong
mesh_terms: D001569:Benzodiazepines / Q000627:therapeutic use; D018755:GABA Agonists / Q000627:therapeutic use; D006801:Humans; D006993:Hypnotics and Sedatives / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D058830:Serotonin 5-HT2 Receptor Antagonists; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D013329:Structure-Activity Relationship
chemical_list: D018755:GABA Agonists; D006993:Hypnotics and Sedatives; D058830:Serotonin 5-HT2 Receptor Antagonists; D001569:Benzodiazepines