Amphidinolides and its related macrolides from marine dinoflagellates.
This review covers the recent results described in our publications on several new cytotoxic macrolides isolated from dinoflagellates of the genus Amphidinium in addition to an overview of the isolation, structure elucidation, synthesis, biosynthesis, and bioactivity of a series of cytotoxic macrolides, named amphidinolides, reported so far.
Kobayashi
Jun'ichi
J
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. jkobay@pharm.hokudai.ac.jp
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D004141:Dinoflagellida / Q000737:chemistry* / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000737:chemistry; D018942:Macrolides / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology
D000903:Antibiotics, Antineoplastic; D007783:Lactones; D018942:Macrolides