title: Predictive value of serum-soluble CD154 in fulminant hepatic failure.
abstract: The interaction of CD40 with CD154 is a pivotal trigger of immune cascade-inducing acute liver failure, however its clinical significance has not been well studied. The present study aimed to investigate the clinical implications of serum-soluble CD154 (sCD154) levels and the expression of CD40 on monocytes in patients with fulminant hepatic failure (FHF). The results showed that serum sCD154 levels and CD40 expression on monocytes were significantly higher in FHF patients than in acute hepatitis (AH) patients and healthy controls, and were also significantly higher in FHF patients who died, compared with those who survived. We conclude that high serum levels of sCD154 may be linked to fatal outcome in patients with severe liver injury and may be a valuable prognostic marker for survival in patients with FHF.
authors.affiliation: Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Y B
authors.initials: YB
authors.lastname: Zheng
authors.forename: Z L
authors.initials: ZL
authors.lastname: Gao
authors.forename: F
authors.initials: F
authors.lastname: Zhong
authors.forename: Y S
authors.initials: YS
authors.lastname: Huang
authors.forename: L
authors.initials: L
authors.lastname: Peng
authors.forename: B L
authors.initials: BL
authors.lastname: Lin
authors.forename: Y T
authors.initials: YT
authors.lastname: Chong
mesh_terms: D000818:Animals; D023201:CD40 Ligand / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D017114:Liver Failure, Acute / Q000097:blood* / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D009000:Monocytes / Q000166:cytology / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D023201:CD40 Ligand