Acylphenols from Myristica crassa as new acetylcholinesterase inhibitors.
A significant acetylcholinesterase inhibitory activity was observed for the ethyl acetate and methanol extracts from the leaves and the fruits of MYRISTICA CRASSA. Three new dimeric acylphenols, giganteone C ( 5), maingayones B and C ( 6 and 7) were isolated together with the known malabaricones B and C ( 2 and 3) and giganteone A ( 4). Compounds 2 and 3 possess significant inhibitory activity on acetylcholinesterase. LC/MS study was particularly useful to discriminate structures of compounds 6 and 7.
Maia
Alessandra
A
Institut de Chimie des Substances Naturelles, UPR-2301, CNRS, Gif-sur-Yvette Cedex France.
Schmitz-Afonso
Isabelle
I
Martin
Marie-Thérèse
MT
Awang
Khalijah
K
Laprévote
Olivier
O
Guéritte
Françoise
F
Litaudon
Marc
M
D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D013058:Mass Spectrometry; D026324:Myristicaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D010636:Phenols