Stawamycin analog, JBIR-11 from Streptomyces viridochromogenes subsp. sulfomycini NBRC 13830.
A stawamycin analog, JBIR-11 (1) was isolated from mycelium of Streptomyces viridochromogenes subsp. sulfomycini NBRC 13830. The structure was determined on the basis of the spectroscopic data. Compound 1 exhibited growth inhibitory effect against human fibrosarcoma HT1080 cells with an IC50 value of 25 microM.
Izumikawa
Miho
M
Japan Biological Information Research Center (JBIRC), Japan Biological Informatics Consortium (JBIC), Aomi, Tokyo, Japan.
Komaki
Hisayuki
H
Hashimoto
Junko
J
Takagi
Motoki
M
Shin-ya
Kazuo
K
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D007211:Indoles / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D025282:Mycelium / Q000737:chemistry; D011758:Pyrroles / Q000302:isolation & purification / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D007211:Indoles; C532276:JBIR-11; D011758:Pyrroles