Synthesis and anti-inflammatory activity of 2-aryloxy methyl oxazolines.
A series of potential biologically active 2-aryloxy methyl oxazolines 3a-n have been synthesized from substituted hydroxybenzenes 1a-n with good chemical yield. The compounds 3a-n were screened for their anti-inflammatory, ulcerogenic, cyclooxygenase activities and also for their acute toxicity. The potency of the compounds was compared with that of the standard drugs, aspirin and phenyl butazone. The outcome indicates that compounds 3b (48.2%), 3h (48.5%) and 3l (46.5%) offered significant anti-inflammatory activity with low ulcerogenic activity than the standard drugs.
Khanum
Shaukath Ara
SA
Department of Chemistry, Yuvaraja's College, University of Mysore, Mysore, Karnataka 570 005, India. shaukathara@yahoo.co.in
Khanum
Noor Fatima
NF
Shashikanth
M
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001835:Body Weight; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D004487:Edema / Q000188:drug therapy; D019856:Ethanolamine / Q000737:chemistry; D008861:Microsomes / Q000378:metabolism; D008872:Microwaves; D008956:Models, Chemical; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D010653:Phenylbutazone / Q000494:pharmacology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D014456:Ulcer / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D010080:Oxazoles; D019856:Ethanolamine; D011451:Prostaglandin-Endoperoxide Synthases; D010653:Phenylbutazone