[Use of hyperbaric oxygenation as a component of intensive care in acute pancreatitis and its impact on homeostasis and intensity of oxidative stress].
Twenty-two patients diagnosed as having acute pancreatitis (AP) were examined to assess whether hyperbaric oxygen therapy (HBO) was an efficient and safe adjunct to the standardized treatment protocol in patients with AP. The impact of HBO on oxygenation in the splanchnic area, homeostasis, oxidative stress, and intraabdominal hypertension was evaluated. A treatment group consisted of 11 patients treated for 3 days (twice a day) using a monoplace chamber under pressures of 1.7-1.9 ATA. Patients (n = 11) in the control group were managed in accordance with the standardized treatment protocol. HBO improved oxygen delivery to the splanchnic area, positively affected homeostasis and induced no significant intraabdominal pressure changes. HBO demonstrated neither explicit prooxidative effect nor typical complications.
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D000208:Acute Disease; D003131:Combined Modality Therapy; D003422:Critical Care / Q000379:methods*; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000009:adverse effects / Q000379:methods; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D010195:Pancreatitis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D011446:Prospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome