title: Integrins: the keys to unlocking angiogenesis.
abstract: Angiogenesis, the formation of new blood vessels from preexisting vasculature, contributes to the pathogenesis of many disorders, including ischemic diseases and cancer. Integrins are cell adhesion molecules that are expressed on the surface of endothelial cells and pericytes, making them potential targets for antiangiogenic therapy. Here we review the contribution of endothelial and mural cell integrins to angiogenesis and highlight their potential as antiangiogenesis targets.
authors.affiliation: Adhesion and Angiogenesis Group, Centre for Tumour Biology, Cancer Research UK Clinical Centre, Institute of Cancer, Barts &The London & Queen Mary's School of Medicine & Dentistry, John Vane Science Centre, Charterhouse Square, London UK.
authors.forename: Rita
authors.initials: R
authors.lastname: Silva
authors.forename: Gabriela
authors.initials: G
authors.lastname: D'Amico
authors.forename: Kairbaan M
authors.initials: KM
authors.lastname: Hodivala-Dilke
authors.forename: Louise E
authors.initials: LE
authors.lastname: Reynolds
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000187:drug effects; D020286:Pericytes / Q000378:metabolism; D038981:Receptors, Collagen / Q000378:metabolism; D017469:Receptors, Fibronectin / Q000378:metabolism; D017474:Receptors, Laminin / Q000378:metabolism; D019030:Receptors, Vitronectin / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D020533:Angiogenesis Inhibitors; D016023:Integrins; D038981:Receptors, Collagen; D017469:Receptors, Fibronectin; D017474:Receptors, Laminin; D019030:Receptors, Vitronectin