title: Acylphenols from Myristica crassa as new acetylcholinesterase inhibitors.
abstract: A significant acetylcholinesterase inhibitory activity was observed for the ethyl acetate and methanol extracts from the leaves and the fruits of MYRISTICA CRASSA. Three new dimeric acylphenols, giganteone C ( 5), maingayones B and C ( 6 and 7) were isolated together with the known malabaricones B and C ( 2 and 3) and giganteone A ( 4). Compounds 2 and 3 possess significant inhibitory activity on acetylcholinesterase. LC/MS study was particularly useful to discriminate structures of compounds 6 and 7.
authors.affiliation: Institut de Chimie des Substances Naturelles, UPR-2301, CNRS, Gif-sur-Yvette Cedex France.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Maia
authors.forename: Isabelle
authors.initials: I
authors.lastname: Schmitz-Afonso
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Martin
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.forename: Olivier
authors.initials: O
authors.lastname: Laprévote
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D013058:Mass Spectrometry; D026324:Myristicaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D002800:Cholinesterase Inhibitors; D010636:Phenols