title: Reproducibility and validity of radiographically determined gastrointestinal and segmental colonic transit times in spinal cord-injured patients.
abstract: BACKGROUND
  Total gastrointestinal transit times (GITT) and segmental colonic transit times (CTT) are commonly used to describe bowel function in individuals with spinal cord injury (SCI).
  
  
  METHODS
  Reproducibility study.
  
  
  OBJECTIVE
  To describe inter- and intrasubjective as well as interobserver variations in GITT and segmental CTT in patients with SCI. Furthermore, to study associations between GITT or segmental CTT and colorectal symptoms.
  
  
  METHODS
  Spinal Cord Unit, Viborg Hospital, Denmark.
  
  
  METHODS
  Thirty SCI patients took 10 radio-opaque markers on 6 consecutive days and an abdominal X-ray was taken on day 7. The same procedure was repeated after 3 months. GITT and CTT were computed from the number of markers in the entire colorectum and in the left and the right colon. Intra- and interobserver variations were described as dispersion (numerical difference/mean).
  
  
  RESULTS
  Intersubjective variation was large for GITT (range: 0.6-6.3 days), right CTT (range: 0.1-5.5 days) and left CTT (range: 0-4.9 days). Intrasubjective variation was acceptable for GITT (dispersion: 0.28) but less good for right (dispersion: 0.63) and left CTT (dispersion: 0.68). Interobserver variation was very small. No correlations were found between GITT, right or left CTT and colorectal symptoms.
  
  
  CONCLUSIONS
  GITT and right and left CTT are of limited value for clinical decision-making in individual patients but may be useful for comparison of groups of patients with SCI.
authors.affiliation: Viborg Hospital, Viborg, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Media
authors.forename: P
authors.initials: P
authors.lastname: Christensen
authors.forename: I
authors.initials: I
authors.lastname: Lauge
authors.forename: M
authors.initials: M
authors.lastname: Al-Hashimi
authors.forename: S
authors.initials: S
authors.lastname: Laurberg
authors.forename: K
authors.initials: K
authors.lastname: Krogh
mesh_terms: D000328:Adult; D000368:Aged; D003106:Colon / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003718:Denmark; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology; D005772:Gastrointestinal Transit / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011860:Radiography, Abdominal / Q000379:methods*; D015203:Reproducibility of Results; D013119:Spinal Cord Injuries / Q000150:complications / Q000503:physiopathology*; D013997:Time Factors