The effects of the polymorphism in exon 3 of the FAS gene on the death of chicken embryos during the incubation period.
To investigate the effect of a factor-associated suicide (FAS) gene polymorphism on the death of chicken embryos, we genotyped 190 dead embryos and 69 normally developing embryos from 7200 hatching Short-Leg Yellow Chicken eggs, as well as 119 dead embryos and 69 normally developing embryos from 4650 hatching Yellow B Chicken eggs. The results showed that there were significant (P < 0.05) genotypic differences between dead and normally developing embryos for this FAS gene polymorphism, a SNP in exon 3 (NC_006093.2:g.6514A>C, rs15793179). Logistic regression revealed that Short-Leg Yellow Chicken embryos with genotype g.6514CC had a significantly (P < 0.01) higher risk of death than those with genotype g.6514AC. This polymorphism has the potential to be an effective tool when used in conjunction with traditional selection methods.
Wu
J J
JJ
Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.
Li
W M
WM
Zhao
R X
RX
Fang
J
J
Wang
C
C
Peng
X L
XL
Li
X
X
Xiong
J J
JJ
Yang
L G
LG
Zhang
S J
SJ
D000818:Animals; D030161:Avian Proteins / Q000235:genetics*; D002642:Chick Embryo; D002645:Chickens / Q000235:genetics*; D003433:Crosses, Genetic; D005091:Exons; D053222:Fas Ligand Protein / Q000235:genetics*; D005260:Female; D005804:Genes, Lethal; D008297:Male; D011110:Polymorphism, Genetic
D030161:Avian Proteins; D053222:Fas Ligand Protein