Highly chemoselective reduction of aromatic nitro compounds by copper nanoparticles/ammonium formate.
A highly chemoselective reduction of aromatic nitro compounds to the corresponding amino derivatives has been achieved by a combination of copper nanoparticles and ammonium formate in ethylene glycol at 120 degrees C. The reductions are successfully carried out in presence of a wide variety of other reducible functional groups in the molecule, such as Cl, I, OCH2Ph, NHCH2Ph, COR, COOR, CN, etc. The reactions are very clean and high yielding.
Saha
Amit
A
Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India.
Ranu
Brindaban
B