title: Genetic polymorphisms as determinants for disease-preventive effects of vitamin E.
abstract: Polymorphisms in genes involved in vitamin E uptake, distribution, metabolism, and molecular action may be important determinants for the protective effects of vitamin E supplementation. The haptoglobin 2-2 polymorphism is associated with increased production of oxygen free radicals and reduces levels of vitamin E and C; the consequent elevated risk for cardiovascular disease can be prevented by vitamin E supplementation.
authors.affiliation: Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Zingg
authors.forename: Angelo
authors.initials: A
authors.lastname: Azzi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Meydani
mesh_terms: D001205:Ascorbic Acid / Q000097:blood; D019587:Dietary Supplements; D005786:Gene Expression Regulation; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D011110:Polymorphism, Genetic; D014810:Vitamin E / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D014811:Vitamin E Deficiency / Q000188:drug therapy*
chemical_list: C485359:HP protein, human; D006242:Haptoglobins; D014810:Vitamin E; D001205:Ascorbic Acid