title: Differential diagnosis of primary versus metastatic pulmonary adenocarcinomas using gene mutation analyses: a case report.
abstract: A 61-year-old Japanese woman underwent a partial mastectomy for cancer of the right breast (pT1cN0M0, stage I). Eight months later, chest computed tomography revealed two small nodules in the left lower lobe (Segmentum basale laterale and Segmentum basale posterius; S9 and S10). She thereafter underwent partial pulmonary resections for both diagnostic and treatment purposes. The nodule of S10 was pathologically diagnosed to be primary lung cancer. The nodule of S9 was pathologically diagnosed to be poorly differentiated adenocarcinoma. The same pattern of the distribution of the p53 mutation was observed in the DNA samples of the S9 nodule and the treated breast cancer. We therefore finally diagnosed the S9 nodule to be metastatic pulmonary carcinoma. A mutation analysis of the p53 gene is thus considered to be a good modality for differentiating metastases from primary carcinomas of the lung.
authors.affiliation: Division of Thoracic Surgery, Gunma Prefectural Cancer Center, Takabayashi-nishi, Ohta-shi, Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Nakazato
authors.forename: Ryota
authors.initials: R
authors.lastname: Tanaka
authors.forename: Erina
authors.initials: E
authors.lastname: Seki
authors.forename: Misa
authors.initials: M
authors.lastname: Iijima
authors.forename: Masaru
authors.initials: M
authors.lastname: Kojima
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yoshizumi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kato
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kimura
authors.forename: Kunihisa
authors.initials: K
authors.lastname: Kozawa
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Goya
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000235:genetics / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000556:secondary*; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D015409:Mastectomy, Radical; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D016133:Polymerase Chain Reaction; D013965:Thyroidectomy; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53