title: Postprandial lipid responses of butter blend containing fish oil in a single-meal study in humans.
abstract: The postprandial effects of a butter product containing fish oil were investigated in a single-meal, randomized crossover study with a commercial butter product as the control. Twelve healthy males consumed two test meals with (13)C-labelled cholesterol (45 mg) and either an interesterified butter blend with fish oil (352 mg n-3 long-chain PUFA (LCPUFA)) or the commercial butter blend. Blood samples were collected after the meals and in the fasting condition on the test day and the following morning, and were analysed for cholesterol absorption, plasma lipid profile and fatty acid composition. No significant difference in the postprandial plasma fatty acid composition was observed between the groups, neither difference in cholesterol absorption, plasma cholesterol or the cholesterol contents of plasma lipoproteins. The incorporation of fish oil in the butter resulted in a significant lower concentration of triacylglycerols in the plasma 2 h after the meal in comparison with the commercial butter blend (p = 0.02); there was, however, no significant difference 24 h after the meal. In conclusion, fish oil-enriched butter blend provides a source to increase the intake of n-3 LCPUFA in the population, but has no acute effect on cholesterol absorption and plasma cholesterol concentration in human.
authors.affiliation: BioCentrum-DTU, Technical University of Denmark, Lyngby, Denmark.
authors.forename: Julie
authors.initials: J
authors.lastname: Overgaard
authors.forename: Trine
authors.initials: T
authors.lastname: Porsgaard
authors.forename: Zheng
authors.initials: Z
authors.lastname: Guo
authors.forename: Lotte
authors.initials: L
authors.lastname: Lauritzen
authors.forename: Huiling
authors.initials: H
authors.lastname: Mu
mesh_terms: D000328:Adult; D002079:Butter; D002784:Cholesterol / Q000097:blood*; D018592:Cross-Over Studies; D004032:Diet; D004041:Dietary Fats / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D005395:Fish Oils / Q000737:chemistry*; D006801:Humans; D008297:Male; D019518:Postprandial Period / Q000502:physiology*; D014280:Triglycerides / Q000097:blood
chemical_list: D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D014280:Triglycerides; D002079:Butter; D002784:Cholesterol