title: Argusides D and E, two new cytotoxic triterpene glycosides from the sea cucumber Bohadschia argus Jaeger.
abstract: Two new triterpene glycosides, argusides D and E (1 and 2, resp.), have been isolated from the sea cucumber Bohadschia argus Jaeger collected in the South China Sea. Their structures have been established by spectral analysis (ESI-MS, and 1D- and 2D-NMR) and chemical evidence. Compounds 1 and 2 both possess an holostane-type triterpene aglycone with a C(9)=C(11) bond, an OH group at C(12), and tetrasaccharide moieties, but differ in the side chains. The two glycosides exhibited significant cytotoxicities against four human tumor cell lines, A549, HCT-116, HepG2, and MCF-7.
authors.affiliation: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P. R. China.
authors.forename: Bao-Shu
authors.initials: BS
authors.lastname: Liu
authors.forename: Yang-Hua
authors.initials: YH
authors.lastname: Yi
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.forename: Hua
authors.initials: H
authors.lastname: Han
authors.forename: Guo-Quan
authors.initials: GQ
authors.lastname: Sun
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Wang
authors.forename: Zeng-Lei
authors.initials: ZL
authors.lastname: Wang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D019906:Nuclear Magnetic Resonance, Biomolecular; D012616:Sea Cucumbers / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D014315:Triterpenes; C531479:arguside D; C531480:arguside E