[The sexual function of mature rat males after prenatal modulation of cholinergic system].
The data obtained have shown that prenatal exposure of pregnant rat females of 9-19-day pregnancy to N-cholinolytics as compared to M-cholinolytics produce long-term behavioural changes in pubescent rat progeny. Pubescent rat progeny had low dynamics of gaining sexual experience and decreased sexual activity with equal disturbance of motivation and coitus. The number of males with absence of sexual activity was above that of the control group. We suggest that sexual dysfunction of offspring adulthood was provoked by introduction of ganglerone (N-cholinolytic) which had been injected on 9-11 and 12-14 days of gestation, and metamyzil (M-cholinolytic) injected on 9-11 days of gestation. Apparently, regulation of neuronal mechanisms for sexual function is disturbed as a consequence of lasting change in neurotransmitter activity. It is suggested that dopaminergic activity in brain limbic structures was affected the most. The significant decrease in blood testosterone values has also been elucidated.
Baĭramov
A A
AA
Poletaeva
A O
AO
Proshin
S N
SN
Efremov
O M
OM
Sapronov
N S
NS
D000818:Animals; D001535:Benactyzine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D001565:Benzoates / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D005865:Gestational Age; D008032:Limbic System / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010276:Parasympatholytics / Q000009:adverse effects* / Q000494:pharmacology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
D001565:Benzoates; D010276:Parasympatholytics; D013739:Testosterone; C008380:metamizil; D001535:Benactyzine; C007824:ganglerone