Emblica officinalis aqueous extract ameliorates ochratoxin-induced lipid peroxidation in the testis of mice.
The present study was undertaken to assess the ameliorative effect of Emblica officinalis aqueous extract on ochratoxin-induced lipid peroxidation in the testis of mice. Adult male albino mice were orally administered with 50 and 100 microg of ochratoxin (Groups 4, 5) in 0.2 mL olive oil/animal/day for 45 days. The results revealed a significant increase in LPO (lipid peroxidation) in the testis of mice treated with ochratoxin compared to that of vehicle control (Group 2). The levels of non-enzymatic antioxidants: GSH (glutathione) and TAA (total ascorbic acid) as well as enzymatic antioxidants: SOD (superoxide dismutase), CAT (catalase), GPX (glutathione peroxidase), GRX (glutathione reductase) and GST (glutathione transferase) were significantly decreased in the testis of ochratoxin-treated mice. Oral administration of Emblica officinalis aqueous extract (2 mg/animal/day) along with ochratoxin (Groups 6, 7) for 45 days, caused, significant, amelioration in ochratoxin-induced LPO by increasing the contents of non-enzymatic (GSH and TAA) and activities of enzymatic (SOD, CAT, GPX, GRX and GST) antioxidants in the testis of mice as compared with those given ochratoxin alone animals (Groups 4, 5). Thus, oral administration of Emblica officinalis aqueous extract along with ochratoxin significantly ameliorates ochratoxin-induced lipid peroxidation in the testis of mice.
Verma
Ramtej
R
Toxicology Division, Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad 380 009, India. ramtejverma2000@yahoo.com
Chakraborty
Devjani
D
D000818:Animals; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D009793:Ochratoxins / Q000633:toxicity*; D029842:Phyllanthus emblica; D010936:Plant Extracts / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism
D009793:Ochratoxins; D010936:Plant Extracts; D002374:Catalase; D005978:Glutathione