title: Assembly of F0 in Saccharomyces cerevisiae.
abstract: Respiratory deficient mutants of Saccharomyces cerevisiae have been instrumental in identifying an increasing number of nuclear gene products that promote pre- and post-translational steps of the pathway responsible for biogenesis of the mitochondrial ATP synthase. In this article we have attempted to marshal current information about the functions of such accessory factors and the roles they play in expression and assembly of the mitochondrially encoded subunits of the ATP synthase. We also discuss evidence that the ATP synthase may be built up from three separate modules corresponding to the F1 ATPase, the stator and F0.
authors.affiliation: Department of Biological Sciences, Columbia University New York, NY 10027, USA.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Rak
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Zeng
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Brière
authors.forename: Alexander
authors.initials: A
authors.lastname: Tzagoloff
mesh_terms: D008954:Models, Biological; D018832:Molecular Chaperones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011487:Protein Conformation; D021122:Protein Subunits / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006180:Proton-Translocating ATPases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D018832:Molecular Chaperones; D021122:Protein Subunits; D029701:Saccharomyces cerevisiae Proteins; D006180:Proton-Translocating ATPases