Macrophages and hypoxia in human chronic kidney disease.
Chronic kidney disease is characterized by progressive interstitial fibrosis, reduced blood flow, and tubular atrophy, which present a common pathway of destruction irrespective of the initial underlying pathology. There is comprehensive evidence that the interactions of infiltrating macrophages with resident tissue cells play a critical role in this process. A new study now describes the correlation between macrophages, capillary density, and interstitial scarring and suggests distinct differences in early and advanced renal disease.
Erwig
Lars-Peter
LP
Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom. L.P.Erwig@abdn.ac.uk
D006801:Humans; D000860:Hypoxia / Q000473:pathology*; D007668:Kidney / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000473:pathology*; D008264:Macrophages / Q000473:pathology*; D008954:Models, Biological; D009395:Nephritis, Interstitial / Q000473:pathology