Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease.
The question arises as to whether oxidative stress has a primary role in neurodegeneration or is a secondary end-stage epiphenomenon. The aim of the present study was to determine oxidative stress parameters like malondialdehyde (MDA), carbonyl proteins (CP) and Albumin-disulphide (Alb-SSR) and relate these parameters to the immune parameter neopterin, folic acid and vitamin B12 as vitamins and homocysteine in patients with neuro-degenerative diseases (NDD), namely mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared to an aged matched control group. MDA, CP and Alb-SSR were significantly increased in the NDD group compared to controls, but not vitamin B12, folic acid and neopterin. Significant correlations were found between CP and Alb-SSR, CP and MDA and between MDA and Alb-SSR including patients with NDD and the control group. These results support the hypothesis that oxidative damage to lipids and proteins is an important early event in the pathogenesis of neurodegenerative diseases.
Greilberger
J
J
Institute of Physiological Chemistry, Center for Physiological Medicine, Medical University of Graz,8010 Graz, Austria. joachim.greilberger@meduni-graz.at
Koidl
C
C
Greilberger
M
M
Lamprecht
M
M
Schroecksnadel
K
K
Leblhuber
F
F
Fuchs
D
D
Oettl
K
K
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000378:metabolism*; D004220:Disulfides / Q000097:blood*; D005260:Female; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D019798:Neopterin / Q000097:blood; D009410:Nerve Degeneration / Q000378:metabolism*; D018384:Oxidative Stress; D050050:Protein Carbonylation; D012709:Serum Albumin / Q000378:metabolism*; D012720:Severity of Illness Index; D014805:Vitamin B 12 / Q000097:blood
D015415:Biomarkers; D004220:Disulfides; D012709:Serum Albumin; D006710:Homocysteine; D008315:Malondialdehyde; D019798:Neopterin; D005492:Folic Acid; D014805:Vitamin B 12