713A, a new metabolite isolated from a fungal strain 713.
A new compound named 713A was isolated from the fermentation broth of a fungal strain 713. The structure of 713A was elucidated by spectroscopic methods. In the screening for interleukin-6 (IL-6) receptor antagonist, 713A exhibited inhibitory activity to the binding of IL-6 and IL-6 receptor with an IC50 value of 8.6 microM.
Zou
Ying-shu
YS
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Wang
Ke
K
Zhang
Yang
Y
Li
Yuan
Y
Meng
Jie
J
Wu
Jian-bo
JB
D004355:Drug Stability; D005285:Fermentation; D005658:Fungi / Q000737:chemistry* / Q000378:metabolism; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010421:Pentanoic Acids / Q000302:isolation & purification / Q000494:pharmacology*; D019947:Receptors, Interleukin-6 / Q000037:antagonists & inhibitors*
C531493:713A compound; D007546:Isoquinolines; D010421:Pentanoic Acids; D019947:Receptors, Interleukin-6