Role of quorum sensing by Pseudomonas aeruginosa in microbial keratitis and cystic fibrosis.
Pseudomonas aeruginosa is a ubiquitous bacterium that causes opportunistic infections in a range of host tissues and organs. Infections by P. aeruginosa are difficult to treat and hence there is interest in the development of effective therapeutics. One of the key mechanisms that P. aeruginosa uses to control the expression of many virulence factors is the N-acylated homoserine lactone (AHL) regulatory system. Hence, there is considerable interest in targeting this regulatory pathway to develop novel therapeutics for infection control. P. aeruginosa is the principal cause of microbial keratitis and of infections in cystic fibrosis (CF) sufferers, and AHL-dependent cell-to-cell signalling has been shown to be important for both infection types. However, keratitis tends to be an acute infection whereas infection of CF patients develops into a chronic, life-long infection. Thus, it is unclear whether AHL-regulated virulence plays the same role during these infections. This review presents a comparison of the role of AHL signalling in P. aeruginosa-mediated microbial keratitis and chronic lung infections of CF patients.
Willcox
M D P
MDP
Vision CRC, Sydney, Australia.|Institute for Eye Research, Sydney, Australia.|School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.
Zhu
H
H
Vision CRC, Sydney, Australia.|Institute for Eye Research, Sydney, Australia.|School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.
Conibear
T C R
TCR
Vision CRC, Sydney, Australia.|School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.
Hume
E B H
EBH
Vision CRC, Sydney, Australia.|Institute for Eye Research, Sydney, Australia.|School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.
Givskov
M
M
BioScience and Technology, The Technical University of Denmark, DK-2800 Lyngby, Denmark.
Kjelleberg
S
S
School of Biotechnology and Biomolecular Sciences and The Centre for Marine Bio-Innovation, University of New South Wales, Sydney, NSW 2052, Australia.
Rice
S A
SA
School of Biotechnology and Biomolecular Sciences and The Centre for Marine Bio-Innovation, University of New South Wales, Sydney, NSW 2052, Australia.
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000378:metabolism; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D007634:Keratitis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D053038:Quorum Sensing / Q000187:drug effects; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
D037521:Virulence Factors; C088386:homoserine lactone; D015107:4-Butyrolactone