title: Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration.
abstract: The mechanisms underlying in vivo activation of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme that mediates in the brain the induction of depressive-like behavior by peripheral innate immune system stimulation are still poorly understood. By monitoring how cytokines parallel IDO mRNA expression in the brain in response to intraperitoneal lipopolysaccharide injection in mice, we report a time-dependent induction of IDO expression in both the hippocampus and hypothalamus that was associated with a specific structure-dependent expression of proinflammatory cytokines, particularly interferon-gamma. This study suggests that different mechanisms regulate the activation of IDO by lipopolysaccharide in various brain structures.
authors.affiliation: INRA, UMR 1286 PsyNuGen, Université Victor Ségalen Bordeaux 2, CNRS, UMR 5226, IFR8, F-33076 Bordeaux, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: André
authors.forename: Jason C
authors.initials: JC
authors.lastname: O'Connor
authors.forename: Keith W
authors.initials: KW
authors.lastname: Kelley
authors.forename: Jacques
authors.initials: J
authors.lastname: Lestage
authors.forename: Robert
authors.initials: R
authors.lastname: Dantzer
authors.forename: Nathalie
authors.initials: N
authors.lastname: Castanon
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D016207:Cytokines / Q000097:blood* / Q000235:genetics; D015870:Gene Expression / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000201:enzymology; D007031:Hypothalamus / Q000187:drug effects* / Q000201:enzymology; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000097:blood* / Q000235:genetics; D007737:Kynurenine / Q000378:metabolism; D008070:Lipopolysaccharides / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism; D013997:Time Factors; D014364:Tryptophan / Q000378:metabolism
chemical_list: D016207:Cytokines; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D007737:Kynurenine; D014364:Tryptophan