Carbimazole embryopathy-bilateral choanal atresia and patent vitello-intestinal duct: a case report and review of literature.
BACKGROUND
In utero exposure to carbimazole for maternal hyperthyroidism has been reported to cause choanal atresia. There are case reports of patent vitello-intestinal duct and Meckel's diverticulum in similar association.


METHODS
We report another such instance of an infant who was exposed to carbimazole in utero, presenting with bilateral choanal atresia and patent vitello-intestinal duct.


CONCLUSIONS
As there seems to be no reports of a possible association between propylthiouracil and congenital malformations, it may be safer to use propylthiouracil instead of carbimazole.
Kannan
Lakshminarayanan
L
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Mishra
Satish
S
Agarwal
Ramesh
R
Kartikeyan
Venkat
V
Gupta
Neerja
N
Kabra
Madhulika
M
D000014:Abnormalities, Drug-Induced / Q000196:embryology*; D013956:Antithyroid Agents / Q000009:adverse effects*; D002231:Carbimazole / Q000009:adverse effects*; D002754:Choanal Atresia / Q000139:chemically induced* / Q000196:embryology* / Q000601:surgery; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011247:Pregnancy; D014816:Vitelline Duct / Q000002:abnormalities* / Q000196:embryology
D013956:Antithyroid Agents; D002231:Carbimazole