title: Cost-effectiveness analysis of universal childhood vaccination against varicella in Brazil.
abstract: This study conducts a cost-effectiveness analysis of a childhood universal varicella vaccination program in Brazil. An age and time-dependent dynamic model was developed to estimate the incidence of varicella for 30 years. Assuming a single-dose schedule; vaccine efficacy of 85% and coverage of 80%, the program could prevent 74,422,058 cases and 2905 deaths. It would cost R$ 3,178,396,110 and save R$ 660,076,410 to the society and R$ 365,602,305 to the healthcare system. The program is cost-effective (R$ 14,749 and R$ 16,582 per life-year saved under the societal and the healthcare system's perspective, respectively). The program's cost-effectiveness is highly sensitive to the vaccine price and number of doses.
authors.affiliation: Department of Preventive Medicine, University of São Paulo School of Medicine, Av. Dr. Arnaldo, 455 - 2 degrees andar Cerqueira César, São Paulo 01246-903, Brazil. joicevalentim@yahoo.com.br
authors.forename: J
authors.initials: J
authors.lastname: Valentim
authors.forename: A M C
authors.initials: AM
authors.lastname: Sartori
authors.forename: P C
authors.initials: PC
authors.lastname: de Soárez
authors.forename: M
authors.initials: M
authors.lastname: Amaku
authors.forename: R S
authors.initials: RS
authors.lastname: Azevedo
authors.forename: H M D
authors.initials: HM
authors.lastname: Novaes
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D001938:Brazil / Q000453:epidemiology; D002644:Chickenpox / Q000453:epidemiology* / Q000517:prevention & control*; D019433:Chickenpox Vaccine / Q000191:economics* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D017281:Cost of Illness; D003362:Cost-Benefit Analysis; D017048:Health Care Costs; D006760:Hospitalization / Q000191:economics / Q000706:statistics & numerical data; D006801:Humans; D017589:Immunization Programs / Q000191:economics*; D007223:Infant; D032541:Mass Vaccination / Q000191:economics*; D018803:Models, Economic; D015233:Models, Statistical; D014187:Transportation of Patients / Q000191:economics; D055815:Young Adult
chemical_list: D019433:Chickenpox Vaccine