title: Native valve Aspergillus endocarditis complicating lung transplantation.
abstract: We present 2 cases of Aspergillus endocarditis occurring in lung transplant recipients, both of whom were treated with early surgical intervention and triazole anti-fungal agents. Neither had evidence of airway colonization/infection with Aspergillus post-transplant, suggesting hematogenous spread of fungi at the time of surgery as a possible mechanism of infection. One case was successfully treated and discharged from the hospital, but, despite initial recovery, death occurred 10 months later due to a recurrence of Aspergillus endocarditis. Aspergillus endocarditis should be considered a relapsing disease and survivors of the condition should receive ongoing anti-fungal therapy.
authors.affiliation: Cardiothoracic Transplant Unit, Harefield Hospital, Harefield, Middlesex, UK. t.maher@ucl.ac.uk
authors.forename: Toby M
authors.initials: TM
authors.lastname: Maher
authors.forename: Martin R
authors.initials: MR
authors.lastname: Carby
authors.forename: Anne V
authors.initials: AV
authors.lastname: Hall
authors.forename: Nicholas R
authors.initials: NR
authors.lastname: Banner
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Burke
authors.forename: Gilles D
authors.initials: GD
authors.lastname: Dreyfus
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control; D001232:Aspergillus fumigatus; D004696:Endocarditis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D017809:Fatal Outcome; D005260:Female; D006351:Heart Valves / Q000000981:diagnostic imaging / Q000382:microbiology*; D006801:Humans; D016040:Lung Transplantation; D014463:Ultrasonography
chemical_list: D000935:Antifungal Agents