title: Relationship between levels of inflammatory cytokines in the genital tract and CD4+ cell counts in women with acute HIV-1 infection.
abstract: Inflammatory responses at mucosal surfaces after human immunodeficiency virus type 1 (HIV-1) transmission may influence disease outcome. We evaluated levels of interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha, IL-8, IL-10, and IL-12 in genital tract and plasma specimens from 44 women with acute HIV infection and 29 HIV-negative control women (13 of whom were women in the acute HIV infection cohort who had preinfection samples available for analysis). Women with acute HIV infection had significantly elevated levels of IL-6, IL-10, and IL-12 in genital tract specimens and elevated levels of IL-1beta, IL-8, and IL-10 in plasma specimens, compared with HIV-negative control women. Levels of IL-1beta, IL-6, and IL-8 in cervicovaginal specimens from women with acute HIV infection showed a significant inverse correlation with systemic CD4(+) cell counts, suggesting that mucosal inflammation is associated with low CD4(+) cell counts during acute HIV infection.
authors.affiliation: Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban, South Africa.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Bebell
authors.forename: Jo-Ann
authors.initials: JA
authors.lastname: Passmore
authors.forename: Carolyn
authors.initials: C
authors.lastname: Williamson
authors.forename: Koleka
authors.initials: K
authors.lastname: Mlisana
authors.forename: Itua
authors.initials: I
authors.lastname: Iriogbe
authors.forename: Francois
authors.initials: F
authors.lastname: van Loggerenberg
authors.forename: Quarraisha Abdool
authors.initials: QA
authors.lastname: Karim
authors.forename: Salim Abdool
authors.initials: SA
authors.lastname: Karim
mesh_terms: D000208:Acute Disease; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016022:Case-Control Studies; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism* / Q000473:pathology; D015658:HIV Infections / Q000276:immunology / Q000378:metabolism*; D015497:HIV-1; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D009092:Mucous Membrane / Q000378:metabolism / Q000473:pathology
chemical_list: D016207:Cytokines