title: The use of ultra high-performance liquid chromatography for studying hydrolysis kinetics of CL-20 and related energetic compounds.
abstract: Ultra high-performance liquid chromatography (UHPLC) utilizes columns packed with sub-2-mum stationary-phase particles and allows operation with pressures of up to 15,000 psi to yield increased resolution, speed, and sensitivity versus conventional HPLC. This promising new technology was used for the analysis of energetic compounds (RDX, HMX and CL-20) and a selective method was developed on an Acquity UPLC. A fast UHPLC method was applied to determine alkaline hydrolysis reaction kinetics of major energetic compounds. Activation energies of alkaline hydrolysis reaction for CL-20, RDX and HMX were comparable to those in literature, however they were determined in a shorter amount of time due to the speed of analysis of the chromatographic method. The use of liophilic salts (KPF(6)) as mobile-phase additives for the enhancement of separation selectivity of energetic compounds was demonstrated.
authors.affiliation: Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ 07936, United States. alexey.makarov@novartis.com
authors.forename: Alexey
authors.initials: A
authors.lastname: Makarov
authors.forename: Rosario
authors.initials: R
authors.lastname: Lobrutto
authors.forename: Christos
authors.initials: C
authors.lastname: Christodoulatos
authors.forename: Anton
authors.initials: A
authors.lastname: Jerkovich
mesh_terms: D001372:Aza Compounds / Q000737:chemistry*; D001392:Azocines / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D012680:Sensitivity and Specificity; D014227:Triazines / Q000737:chemistry*
chemical_list: C482139:2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaaza-isowurtzitane; D001372:Aza Compounds; D001392:Azocines; D006571:Heterocyclic Compounds; D014227:Triazines; C007950:octogen; C009160:cyclonite