title: Use of 31P magnetic resonance spectroscopy to study the effect of cortical magnesium and energy metabolism after subarachnoid hemorrhage.
abstract: BACKGROUND
  Flow metabolism coupling ensures adequate cerebral oxygenation. When subarachnoid hemorrhage (SAH) occurs, the flow metabolism coupling lost its balance and results in cerebral ischemia and infarction second to cortical magnesium and energy metabolism alternation. During chronic vasospasm, change in cortical energy metabolism is coupled with change in cerebral blood flow after SAH.
  
  
  METHODS
  What kind of noninvasive technique can be used to directly investigate the biochemical environment in the SAH brain? Studies showed that (31)P magnetic resonance spectroscopy ((31)P MRS) is ideally suited to evaluate the pathophysiology of SAH, especially for cortical magnesium and energy metabolism.
  
  
  RESULTS
  The results showed that cortical magnesium and energy metabolism were significantly decreased in both animal models and human beings after SAH by using (31)P MRS, which is associated with the severity and outcome of SAH, especially after aneurysmal SAH.
  
  
  CONCLUSIONS
  (31)P MRS data, combined with other MRI sequences, provide a comprehensive assessment of both structural and functional deficits and a guidance on clinical therapy for SAH.
authors.affiliation: Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Heping
authors.initials: H
authors.lastname: Yang
authors.forename: Xiangqi
authors.initials: X
authors.lastname: Tang
authors.forename: Lihua
authors.initials: L
authors.lastname: Tan
authors.forename: Liuwang
authors.initials: L
authors.lastname: Zeng
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Hu
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D004734:Energy Metabolism; D006801:Humans; D008274:Magnesium / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D010758:Phosphorus; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D013345:Subarachnoid Hemorrhage / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy
chemical_list: D010758:Phosphorus; D008274:Magnesium