title: Serum leptin and ghrelin concentrations of maternal serum, arterial and venous cord blood in healthy and preeclamptic pregnant women.
abstract: Preeclampsia, a common complication of pregnancy, is associated with alteration in the concentration of leptin in maternal blood. The action of leptin is antagonistic to that of ghrelin. Here, we compared the levels of leptin and ghrelin in maternal serum and in arterial and venous cord blood between healthy pregnant women and those suffering from mild and severe preeclampsia. The levels of leptin in maternal and newborn's blood were elevated in both mild and severe preeclamptic patients (p < 0.05). Moreover, serum ghrelin levels were negatively correlated with blood pressure and leptin/ghrelin ratio was decreased in preeclampsia (p < 0.05). We concluded that increased production of ghrelin may represent a compensatory hypotensive mechanism in preeclamptic women.
authors.affiliation: Department of Biochemistry and Clinical Biochemistry, Firat University, Elazig, Turkey. saydin@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Aydin
authors.forename: S P
authors.initials: SP
authors.lastname: Guzel
authors.forename: S
authors.initials: S
authors.lastname: Kumru
authors.forename: Suna
authors.initials: S
authors.lastname: Aydin
authors.forename: O
authors.initials: O
authors.lastname: Akin
authors.forename: E
authors.initials: E
authors.lastname: Kavak
authors.forename: I
authors.initials: I
authors.lastname: Sahin
authors.forename: M
authors.initials: M
authors.lastname: Bozkurt
authors.forename: I
authors.initials: I
authors.lastname: Halifeoglu
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D001158:Arteries; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D005312:Fetal Blood; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D020738:Leptin / Q000097:blood*; D011225:Pre-Eclampsia / Q000378:metabolism* / Q000503:physiopathology*; D011247:Pregnancy; D014680:Veins
chemical_list: D054439:Ghrelin; D020738:Leptin