Total synthesis of malformin C, an inhibitor of bleomycin-induced G2 arrest.
Total synthesis of a fungal cyclic peptide, malformin C, recently rediscovered as a G2 checkpoint inhibitor was completed. Our synthesis involved a convergent approach with respect to a linear pentapeptide, cyclization, and oxidative disulfide formation.
Kojima
Yasuhiro
Y
Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
Sunazuka
Toshiaki
T
Nagai
Kenichiro
K
Julfakyan
Khachatur
K
Fukuda
Takashi
T
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000903:Antibiotics, Antineoplastic / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D001761:Bleomycin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D003500:Cyclization; D004249:DNA Damage / Q000187:drug effects; D004220:Disulfides / Q000737:chemistry; D016195:G2 Phase / Q000187:drug effects*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
D000903:Antibiotics, Antineoplastic; D004220:Disulfides; D007202:Indicators and Reagents; D010456:Peptides, Cyclic; D001761:Bleomycin; C001675:malformins