title: Creatine and creatine kinase in health and disease--a bright future ahead?
abstract: Many links are reported or suspected between the functioning of creatine, phosphocreatine, the creatine kinase isoenzymes or the creatine biosynthesis enzymes on one hand, and health or disease on the other hand. The aim of the present book was to outline our current understanding on many of these links. In this chapter, we summarize the main messages and conclusions presented in this book. In addition, we refer to a number of recent publications that highlight the pleiotropy in physiological functions of creatine and creatine kinase, and which suggest that numerous discoveries on new functions of this system are still ahead of us. Finally, we present our views on the most promising future avenues of research to deepen our knowledge on creatine and creatine kinase. In particular, we elaborate on how state-of-the-art high-throughput analytical ("omics") technologies and systems biology approaches may be used successfully to unravel the complex network of interdependent physiological functions related to creatine and creatine kinase.
authors.affiliation: DSM Nutritional Products Ltd., Biotechnology R&D, Bldg. 203/17B, P.O. Box 3255, CH-4002 Basel, Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Wyss
authors.forename: Olivier
authors.initials: O
authors.lastname: Braissant
authors.forename: Ivo
authors.initials: I
authors.lastname: Pischel
authors.forename: Gajja S
authors.initials: GS
authors.lastname: Salomons
authors.forename: Andreas
authors.initials: A
authors.lastname: Schulze
authors.forename: Sylvia
authors.initials: S
authors.lastname: Stockler
authors.forename: Theo
authors.initials: T
authors.lastname: Wallimann
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends; D003402:Creatine Kinase / Q000378:metabolism*; D004194:Disease; D005544:Forecasting; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D010725:Phosphocreatine; D003402:Creatine Kinase