title: Subacute cutaneous lupus erythematosus and interstitial myositis occurring with hepatitis B infection: response to antiviral therapy with lamivudine.
abstract: Lupus erythematosus (LE) is a multisystem inflammatory disease resulting from an altered T- and B-cell response. Among various pathogenic factors, viral infections have been implicated in LE exacerbation. We describe a patient with acute onset of subacute cutaneous lupus erythematosus (SCLE) and interstitial myositis with mitochondrial changes in the context of an associated hepatitis B infection and the response of myositis to antiviral treatment with lamivudine. Viral vectors may play an important role in LE. A hitherto undescribed myositis with mitochondrial changes was associated with hepatitis B infection and SCLE and improved with antiviral treatment.
authors.affiliation: Department of Dermatology, Medical University Graz, Graz, Austria.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Gruber-Wackernagel
authors.forename: Michael
authors.initials: M
authors.lastname: Scarpatetti
authors.forename: Martin Jochen
authors.initials: MJ
authors.lastname: Gruber
authors.forename: Josef
authors.initials: J
authors.lastname: Hermann
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Aberer
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D008178:Lupus Erythematosus, Cutaneous / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D008928:Mitochondria / Q000473:pathology; D009220:Myositis / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D012867:Skin / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D019259:Lamivudine