title: Synthesis of two persistent fluorinated tetrathiatriarylmethyl (TAM) radicals for biomedical EPR applications.
abstract: Tetrathiatriarylmethyl radicals are attractive spin probes extensively used in biomedical magnetic resonance applications. We report a straightforward synthesis of two original tetrathiatriarylmethyl radicals incorporating, respectively, 15 and 45 fluorine atoms, and thus possessing a high affinity to fluorous media. F15T-03 and F45T-03 exhibit a single sharp EPR spectrum and their EPR line broadening is highly sensitive to molecular oxygen. These spin probes are specially designed for assessment of tumor oxygenation using perfluorocarbon formulations.
authors.affiliation: Unité de Chimie Organique et Médicinale, Université catholique de Louvain, UCL, place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium.
authors.forename: Benoît
authors.initials: B
authors.lastname: Driesschaert
authors.forename: Nicolas
authors.initials: N
authors.lastname: Charlier
authors.forename: Bernard
authors.initials: B
authors.lastname: Gallez
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Marchand-Brynaert
mesh_terms: D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005609:Free Radicals / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism; D013440:Sulfides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C530570:F15T-03; C530571:F45T-03; D005609:Free Radicals; D006845:Hydrocarbons, Fluorinated; D013440:Sulfides; D010100:Oxygen