Oxidative destruction of mitochondrial translation products after fractionated irradiation of rats with tumor.
We demonstrated specific features of oxidative damage to mitochondrial translation products in animals were revealed after fractionated X-ray exposure in low doses. Differences were found in carbonylation and oxidation of SH groups in irradiated rats and irradiated tumor-bearing animals. Our results indicate that preliminary fractionated X-ray exposure determines oxidative damage to these mitochondrial proteins only at the initial stage of the study, while in the follow-up period major role is played the by tumor development.
Marchenko
M M
MM
Department of Biochemistry, Yurii Fed'kovich Chernovitsk National University.
Kopyl'chuk
G P
GP
Voloshchuk
O M
OM
D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000378:metabolism / Q000473:pathology; D008297:Male; D008928:Mitochondria / Q000378:metabolism / Q000528:radiation effects*; D024101:Mitochondrial Proteins / Q000096:biosynthesis*; D010084:Oxidation-Reduction / Q000528:radiation effects; D014176:Protein Biosynthesis / Q000528:radiation effects*; D050050:Protein Carbonylation / Q000528:radiation effects; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology; D014965:X-Rays
D024101:Mitochondrial Proteins