title: New labdane diterpenes from Leonurus cardiaca.
abstract: Leonurus cardiaca L. has been used in oriental medicine against several types of disorders. The ethanolic extract of leaves of Leonurus cardiaca yielded three new labdane-type diterpenes: 15- O-ethylleopersin C (1), 15- O-methylleopersin C (2), and 15- EPI- O-methylleopersin C (3). Their structures were determined using 1 D and 2 D NMR including 1H-1H COSY, HMQC, HMBC, and ROESY spectroscopic techniques. Compounds (1 - 3) were evaluated for in vitro antiplasmodial activity (D6 and W2 clones) and cytotoxicity (Vero cells).
authors.affiliation: National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi, USA.
authors.forename: Vijai K
authors.initials: VK
authors.lastname: Agnihotri
authors.forename: Hala N
authors.initials: HN
authors.lastname: Elsohly
authors.forename: Troy J
authors.initials: TJ
authors.lastname: Smillie
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
authors.forename: Larry A
authors.initials: LA
authors.lastname: Walker
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031332:Leonurus / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D014709:Vero Cells
chemical_list: D004224:Diterpenes