title: Tissue-specific shRNA delivery: a novel approach for gene therapy in cancer.
abstract: A novel tissue-specific shRNA delivery system has been developed using cre-lox technology. Conditionally silenced pSico vector containing oligonucleotides of CD44shRNA and tissue-specific promoter-driven Cre-recombinase expression vector are packaged into transferrin-coated nanoparticles that can deliver shRNA into specific tumors. This system has strong potential in cancer therapy.
authors.affiliation: Department of Cell Biology and Anatomy, MUSC, Charleston, South Carolina 29425, USA. ghatak@musc.edu
authors.forename: Shilenath
authors.initials: S
authors.lastname: Ghatak
authors.forename: Viacent C
authors.initials: VC
authors.lastname: Hascall
authors.forename: Franklin G
authors.initials: FG
authors.lastname: Berger
authors.forename: Maria M O
authors.initials: MM
authors.lastname: Penas
authors.forename: Celestia
authors.initials: C
authors.lastname: Davis
authors.forename: Esmaiel
authors.initials: E
authors.lastname: Jabari
authors.forename: Xuezhong
authors.initials: X
authors.lastname: He
authors.forename: James S
authors.initials: JS
authors.lastname: Norris
authors.forename: Yujing
authors.initials: Y
authors.lastname: Dang
authors.forename: Roger R
authors.initials: RR
authors.lastname: Markwald
authors.forename: Suniti
authors.initials: S
authors.lastname: Misra
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism / Q000628:therapy; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000378:metabolism / Q000628:therapy; D005260:Female; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics* / Q000378:metabolism; D006820:Hyaluronic Acid / Q000378:metabolism*; D019426:Integrases / Q000378:metabolism; D008297:Male; D053758:Nanoparticles; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000628:therapy; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics*; D014162:Transfection
chemical_list: D018960:Hyaluronan Receptors; D034741:RNA, Small Interfering; D006820:Hyaluronic Acid; C045073:Cre recombinase; D019426:Integrases