title: Efficient parallel synthesis of macrocyclic peptidomimetics.
abstract: A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A key feature of the method is access to broad chemical and conformational diversity. Synthesis and mechanistic studies on the macrocyclization step are reported.
authors.affiliation: Tranzyme Pharma Inc. 3001, 12e av. Nord, Sherbrooke, Que., Canada J1H5N4. emarsault@tranzyme.com
authors.forename: Eric
authors.initials: E
authors.lastname: Marsault
authors.forename: Hamid R
authors.initials: HR
authors.lastname: Hoveyda
authors.forename: René
authors.initials: R
authors.lastname: Gagnon
authors.forename: Mark L
authors.initials: ML
authors.lastname: Peterson
authors.forename: Martin
authors.initials: M
authors.lastname: Vézina
authors.forename: Carl
authors.initials: C
authors.lastname: Saint-Louis
authors.forename: Annick
authors.initials: A
authors.lastname: Landry
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Pinault
authors.forename: Luc
authors.initials: L
authors.lastname: Ouellet
authors.forename: Sophie
authors.initials: S
authors.lastname: Beauchemin
authors.forename: Sylvie
authors.initials: S
authors.lastname: Beaubien
authors.forename: Axel
authors.initials: A
authors.lastname: Mathieu
authors.forename: Kamel
authors.initials: K
authors.lastname: Benakli
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.forename: Martin
authors.initials: M
authors.lastname: Brassard
authors.forename: David
authors.initials: D
authors.lastname: Lonergan
authors.forename: François
authors.initials: F
authors.lastname: Bilodeau
authors.forename: Mahesh
authors.initials: M
authors.lastname: Ramaseshan
authors.forename: Nadia
authors.initials: N
authors.lastname: Fortin
authors.forename: Ruoxi
authors.initials: R
authors.lastname: Lan
authors.forename: Shigui
authors.initials: S
authors.lastname: Li
authors.forename: Fabrice
authors.initials: F
authors.lastname: Galaud
authors.forename: Véronique
authors.initials: V
authors.lastname: Plourde
authors.forename: Manon
authors.initials: M
authors.lastname: Champagne
authors.forename: Annie
authors.initials: A
authors.lastname: Doucet
authors.forename: Patrick
authors.initials: P
authors.lastname: Bhérer
authors.forename: Maude
authors.initials: M
authors.lastname: Gauthier
authors.forename: Gilles
authors.initials: G
authors.lastname: Olsen
authors.forename: Gérald
authors.initials: G
authors.lastname: Villeneuve
authors.forename: Shridhar
authors.initials: S
authors.lastname: Bhat
authors.forename: Laurence
authors.initials: L
authors.lastname: Foucher
authors.forename: Daniel
authors.initials: D
authors.lastname: Fortin
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Peng
authors.forename: Sylvain
authors.initials: S
authors.lastname: Bernard
authors.forename: Alexandre
authors.initials: A
authors.lastname: Drouin
authors.forename: Robert
authors.initials: R
authors.lastname: Déziel
authors.forename: Gilles
authors.initials: G
authors.lastname: Berthiaume
authors.forename: Yves L
authors.initials: YL
authors.lastname: Dory
authors.forename: Graeme L
authors.initials: GL
authors.lastname: Fraser
authors.forename: Pierre
authors.initials: P
authors.lastname: Deslongchamps
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D019281:Dimerization; D004151:Dipeptides; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry; D010456:Peptides, Cyclic / Q000737:chemistry*; D012834:Silver / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004151:Dipeptides; D010455:Peptides; D010456:Peptides, Cyclic; D012834:Silver