title: Psychopathological factors, memory disorders and transient global amnesia.
abstract: BACKGROUND
  Some studies have shown the presence of psychopathological disorders in transient global amnesia.
  
  
  OBJECTIVE
  To determine whether transient global amnesia is associated with psychopathological disorders and to assess the influence of these psychopathological disorders on memory impairments.
  
  
  METHODS
  Levels of anxiety and depression before and during transient global amnesia were rated. Memory performances were assessed by means of original episodic memory tasks and working memory tasks. These data were collected in 17 individuals observed during the very acute phase, 18 individuals examined in the peri-acute phase and 26 controls.
  
  
  RESULTS
  During the acute phase, participants with transient global amnesia displayed a higher level of anxiety and a more depressed mood than controls. An alteration of emotional state, as measured by the Adjective Mood Scale, was correlated with deficits in anterograde memory.
  
  
  CONCLUSIONS
  Transient global amnesia comprises sudden changes in people's emotional state, which has a major impact on and interacts with episodic memory impairment.
authors.affiliation: Inserm, EPHE, Université de Caen Basse-Normandie, Caen, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Noël
authors.forename: Peggy
authors.initials: P
authors.lastname: Quinette
authors.forename: Bérengère
authors.initials: B
authors.lastname: Guillery-Girard
authors.forename: Jacques
authors.initials: J
authors.lastname: Dayan
authors.forename: Pascale
authors.initials: P
authors.lastname: Piolino
authors.forename: Sophie
authors.initials: S
authors.lastname: Marquis
authors.forename: Vincent
authors.initials: V
authors.lastname: de la Sayette
authors.forename: Fausto
authors.initials: F
authors.lastname: Viader
authors.forename: Béatrice
authors.initials: B
authors.lastname: Desgranges
authors.forename: Francis
authors.initials: F
authors.lastname: Eustache
mesh_terms: D000339:Affect; D000368:Aged; D020236:Amnesia, Transient Global / Q000503:physiopathology* / Q000523:psychology; D000704:Analysis of Variance; D001007:Anxiety / Q000523:psychology; D016022:Case-Control Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000503:physiopathology; D008875:Middle Aged; D009483:Neuropsychological Tests; D012307:Risk Factors