title: Enhancement of cell function through heterotypic cell-cell interactions using E-cadherin-expressing NIH3T3 cells.
abstract: An epithelial cell adhesion molecule, E-cadherin was expressed in NIH3T3 fibroblasts, and cell-cell interactions between keratinocytes and fibroblasts, or between hepatocytes and fibroblasts were artificially engineered. When the E-cadherin-expressing NIH3T3 cells were co-cultured with rat hepatocytes, the cell-cell contacts were formed with high frequency, and enhanced albumin secretion was observed.
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Kyushu University, Fukuoka, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ito
authors.forename: Takehiko
authors.initials: T
authors.lastname: Kiyohara
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kawabe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ijima
authors.forename: Masamichi
authors.initials: M
authors.lastname: Kamihira
mesh_terms: D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D002450:Cell Communication / Q000502:physiology*; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism*; D051379:Mice; D008856:Microscopy, Fluorescence / Q000379:methods*; D041681:NIH 3T3 Cells; D011994:Recombinant Proteins / Q000378:metabolism
chemical_list: D015820:Cadherins; D011994:Recombinant Proteins