title: Anticipating issues related to increasing preimplantation genetic diagnosis use: a research agenda.
abstract: Increasing use of preimplantation genetic diagnosis (PGD) poses numerous clinical, social, psychological, ethical, legal and policy dilemmas, many of which have received little attention. Patients and providers are now considering and using PGD for a widening array of genetic disorders, and patients may increasingly seek 'designer babies.' In the USA, although governmental oversight policies have been discussed, few specific guidelines exist. Hence, increasingly, patients and providers will face challenging ethical and policy questions of when and for whom to use PGD, and how it should be financed. These issues should be better clarified and addressed through collection of data concerning the current use of PGD in the USA, including factors involved in decision making about PGD use, as well as the education of the various communities that are, and should be, involved in its implementation. Improved understanding of these issues will ultimately enhance the development and implementation of future clinical guidelines and policies.
authors.affiliation: College of Physicians and Surgeons and Mailman School of Public Health, Columbia University, New York, USA. rlk2@columbia.edu
authors.forename: Robert
authors.initials: R
authors.lastname: Klitzman
authors.forename: Paul S
authors.initials: PS
authors.lastname: Appelbaum
authors.forename: Wendy
authors.initials: W
authors.lastname: Chung
authors.forename: Mark
authors.initials: M
authors.lastname: Sauer
mesh_terms: D003657:Decision Making; D004992:Ethics, Medical; D005260:Female; D005307:Fertilization in Vitro / Q000941:ethics / Q000379:methods; D020022:Genetic Predisposition to Disease / Q000235:genetics; D033161:Government Regulation; D006801:Humans; D008297:Male; D008423:Maternal Age; D011050:Policy Making; D019836:Preimplantation Diagnosis / Q000191:economics / Q000941:ethics*; D011369:Professional-Patient Relations; D011640:Public Policy; D027724:Reproductive Techniques, Assisted / Q000191:economics / Q000941:ethics*; D012743:Sex Preselection / Q000941:ethics