title: Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A.
abstract: Synthesis and testing of dafachronic acid A ( 1) and its derivatives 2 and 3 have revealed that 1, and not a further oxidation product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
authors.forename: Simon
authors.initials: S
authors.lastname: Giroux
authors.forename: Axel
authors.initials: A
authors.lastname: Bethke
authors.forename: Nicole
authors.initials: N
authors.lastname: Fielenbach
authors.forename: Adam
authors.initials: A
authors.lastname: Antebi
authors.forename: E J
authors.initials: EJ
authors.lastname: Corey
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D029742:Caenorhabditis elegans Proteins / Q000737:chemistry / Q000187:drug effects* / Q000235:genetics; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D008968:Molecular Conformation; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000187:drug effects* / Q000235:genetics; D013237:Stereoisomerism; D014158:Transcription, Genetic / Q000187:drug effects / Q000235:genetics
chemical_list: D029742:Caenorhabditis elegans Proteins; C410905:DAF-12 protein, C elegans; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; C528461:dafachronic acid A; D004875:Ergosterol