title: Re-excretion of infectious bronchitis virus in chickens induced by cyclosporin.
abstract: Following inoculation of day-old chicks with Moroccan strain 'G' of infectious bronchitis virus (IBV) which has a predilection for the gut, virus was recovered from the trachea up to day 7 and from the cloaca up to day 35. After this no virus could be detected, even following the natural stress of re-housing with unfamiliar birds at 9 weeks. When the birds were 12.5 weeks old, they were injected with cyclosporin, a selective T-cell suppressor. Four of the five birds re-excreted virus very erratically, as did two of five contacts. This was accompanied by the appearance of IBV-specific IgM in the sera of both groups. The results suggest that in long-term infections with IBV, virus persistence is controlled by T lymphocytes.
authors.affiliation: Department of Veterinary Pathology, Veterinary Field Station, University of Liverpool, Neston, South Wirral, UK.
authors.forename: P S
authors.initials: PS
authors.lastname: Bhattacharjee
authors.forename: S D
authors.initials: SD
authors.lastname: Carter
authors.forename: C E
authors.initials: CE
authors.lastname: Savage
authors.forename: R C
authors.initials: RC
authors.lastname: Jones