title: Instant tooth whitening from a silica toothpaste containing blue covarine.
abstract: OBJECTIVE
  To measure the instant whitening effect delivered immediately after brushing with a novel silica whitening toothpaste containing blue covarine.
  
  
  METHODS
  A controlled, single blind, cross-over study was performed to compare the tooth colour measured in a group of subjects at baseline and immediately after brushing with a silica whitening toothpaste containing blue covarine versus a clear gel negative control toothpaste. Measurements of tooth colour were made using a mobile non-contact camera-based digital imaging system and expressed as CIELAB and WIO whiteness index.
  
  
  RESULTS
  Analysis of covariance (ANCOVA) showed that the silica whitening toothpaste containing blue covarine was significantly more effective than the negative control toothpaste (p < 0.05), and made teeth measurably less yellow, less red and overall whiter immediately after brushing.
  
  
  CONCLUSIONS
  A statistically significant reduction in tooth yellowness and improvement in tooth whiteness was measured immediately after brushing with a novel whitening toothpaste containing blue covarine.
authors.affiliation: Unilever Oral Care, Quarry Road East, Bebington, Wirral CH63 3JW, UK. luisa.z.collins@unilever.com
authors.forename: Luisa Z
authors.initials: LZ
authors.lastname: Collins
authors.forename: Mojgan
authors.initials: M
authors.lastname: Naeeni
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Platten
mesh_terms: D000328:Adult; D000368:Aged; D003116:Color; D003124:Colorimetry / Q000295:instrumentation; D004396:Coloring Agents / Q000627:therapeutic use*; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation; D007211:Indoles / Q000627:therapeutic use*; D054833:Isoindoles / Q000627:therapeutic use*; D008297:Male; D008665:Metalloporphyrins / Q000627:therapeutic use*; D008875:Middle Aged; D055095:Optics and Photonics; D023861:Photography, Dental / Q000295:instrumentation; D012822:Silicon Dioxide / Q000627:therapeutic use*; D016037:Single-Blind Method; D014070:Tooth / Q000033:anatomy & histology; D014073:Tooth Bleaching / Q000379:methods*; D014100:Toothpastes / Q000627:therapeutic use*
chemical_list: D004396:Coloring Agents; D007211:Indoles; D054833:Isoindoles; D008665:Metalloporphyrins; D014100:Toothpastes; C532297:blue covarine; D012822:Silicon Dioxide; C013647:phthalocyanine