title: Free jejunal flaps can be monitored by use of microdialysis.
abstract: When new combinations of preoperative treatments of carcinoma of the esophagus are implemented, surgical morbidity and mortality become even more important risk factors. This study investigated whether the risk of postoperative complications caused by ischemia in the reconstructed esophagus can be reduced using microdialysis as monitoring method. This is a retrospective study of 14 patients undergoing resection of carcinoma in the upper part of the esophagus and reconstruction with a free jejunal flap. The metabolism in all 14 jejunal transfers was monitored by use of microdialysis. The data were analyzed looking for reliable parameters detecting critical ischemia. Critical ischemia was suspected in two cases. Both of these cases were surgically revised, ischemia in the jejunal flap was verified, and the jejunal flaps were revascularized. All 14 jejunal flaps survived. Using the concentration of glucose in the microdialysate, it was possible to detect the two cases of critical ischemia. Yet, the most reliable parameter seemed to be the retrospectively calculated lactate:glucose ratio; in both the ischemic flaps, the lactate:glucose ratio exceeded more than 1000% the maximum values found in all the nonischemic flaps. Microdialysis is a promising monitoring method for surveillance of free jejunal flaps.
authors.affiliation: Department of Plastic Surgery, Aarhus University Hospital, Norrebrogade, Aarhus, Denmark. hanne.birke@as.aaa.dk
authors.forename: Hanne Birke
authors.initials: HB
authors.lastname: Sorensen
mesh_terms: D000368:Aged; D004938:Esophageal Neoplasms / Q000601:surgery; D004944:Esophagoplasty; D004947:Esophagus / Q000601:surgery*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007511:Ischemia / Q000175:diagnosis; D007583:Jejunum / Q000378:metabolism / Q000637:transplantation*; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D008875:Middle Aged; D008991:Monitoring, Physiologic; D019289:Pyruvic Acid / Q000378:metabolism; D013524:Surgical Flaps / Q000098:blood supply / Q000502:physiology*
chemical_list: D019344:Lactic Acid; D019289:Pyruvic Acid; D005947:Glucose