Anxiety and depression symptoms as risk factors for non-adherence to antiretroviral therapy in Brazil.
Depression and anxiety are common among HIV-infected people and rank among the strongest predictors of non-adherence to antiretroviral therapy (ART). This longitudinal study aimed to assess whether symptoms of anxiety and depression are predictors of non-adherence among patients initiating ART at two public referral centers (n = 293) in Belo Horizonte, Brazil. Prevalence of severe anxiety and depression symptoms before starting ART was 12.6% and 5.8%, respectively. Severe anxiety was a predictor of non-adherence to ART during follow-up period (RH = 1.87; 95% CI = 1.14-3.06) adjusted for low education, unemployment, alcohol use in the last month and symptoms of AIDS; while a history of injection drug use had borderline statistical significance with non-adherence. These findings suggest that using a brief screening procedure to assess anxiety and depression symptoms before initiating ART help identify individuals for interventions to improve adherence and quality of life.
Campos
Lorenza Nogueira
LN
Department of Preventive and Social Medicine, School of Medicine, Federal University of Minas Gerais, Av. Prof. Alfredo Balena 190, Bairro Santa Efigênia, CEP 30130-100, Belo Horizonte, MG, Brazil. lorenza@medicina.ufmg.br
Guimarães
Mark Drew Crosland
MD
Remien
Robert H
RH
D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy / Q000503:physiopathology*; D001938:Brazil; D015331:Cohort Studies; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1; D006801:Humans; D008297:Male; D010349:Patient Compliance; D011237:Predictive Value of Tests; D012307:Risk Factors
D019380:Anti-HIV Agents