[Prelymphoma as a stage of malignant lymphoma (baboon malignant lymphoma model)].
Ten percent of the monkeys (more then 400 animals) from P. hamadrias herd of Sukhumi monkey colony died of a 20 year-long enzootic of malignant lymphoma associated with STLV-1 retrovirus. Retrospective analysis revealed regular (in more than 80% of cases) development of prelymphoma preceded by malignant process for a considerable time (up to 10 years or more). Prelymphoma occurred as mild hemopoietic inhibition including lymphopoiesis. Clinico-morphological signs of prelymphoma were: hypoplasia, edema and discomplexation in lymph nodes, anemia and inflammatory, i. e. degenerative lesions of the skin and mucous membranes.
Iakovleva
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LA
D000818:Animals; D006800:Deltaretrovirus Infections / Q000473:pathology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D008223:Lymphoma / Q000473:pathology* / Q000503:physiopathology* / Q000821:virology; D038041:Lymphopoiesis; D008297:Male; D009367:Neoplasm Staging; D048529:Papio hamadryas; D012189:Retrospective Studies; D015303:Simian T-lymphotropic virus 1