title: Progressive leukoencephalopathy associated with aluminum deposits in myelin sheath.
abstract: A 20-year-old woman with progressive leukoencephalopathy developed mental and motor disabilities and fell into a coma after suffering head trauma and febrile episodes from infancy. Brain imaging showed massive abnormal signals in the white matter. The electron spectroscopic imaging of biopsied brain tissue confirmed the electron-dense deposits to be associated with aluminum accumulation in the myelin sheath. Her brain pathology, which showed ferritin- and naphtochrome green-positive deposits, supported the imaging analysis. The clinicopathological features indicate a new form of progressive leukoencephalopathy.
authors.affiliation: National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan. itoh@ncnp.go.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Itoh
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugai
authors.forename: Naofumi
authors.initials: N
authors.lastname: Kozuka
authors.forename: Naofumi
authors.initials: N
authors.lastname: Ozuka
authors.forename: Maki
authors.initials: M
authors.lastname: Ohsawa
authors.forename: Taisuke
authors.initials: T
authors.lastname: Otsuki
authors.forename: Yu-Ichi
authors.initials: Y
authors.lastname: Goto
mesh_terms: D000328:Adult; D000535:Aluminum / Q000032:analysis* / Q000633:toxicity*; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology*; D003711:Demyelinating Diseases / Q000139:chemically induced* / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D046032:Microscopy, Energy-Filtering Transmission Electron; D009186:Myelin Sheath / Q000187:drug effects / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000139:chemically induced* / Q000473:pathology*; D009460:Neurologic Examination; D013702:Temporal Lobe / Q000187:drug effects / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000535:Aluminum