title: Cyanopeptoline CB071: a cyclic depsipeptide isolated from the freshwater cyanobacterium Aphanocapsa sp.
abstract: Cyanopeptolin CB071 (1), a trypsin inhibitor, was isolated from the freshwater cyanobacterium Aphanocapsa sp. Its complete structure was determined by detailed NMR spectroscopy and MS analyses, along with chemical reactions. The compound showed inhibition of trypsin at a concentration of IC50=2.5 microM.
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, Seoul, Korea.
authors.forename: Hyukjae
authors.initials: H
authors.lastname: Choi
authors.forename: Sun Kwan
authors.initials: SK
authors.lastname: Oh
authors.forename: Wonho
authors.initials: W
authors.lastname: Yih
authors.forename: Jungwook
authors.initials: J
authors.lastname: Chin
authors.forename: Heonjoong
authors.initials: H
authors.lastname: Kang
authors.forename: Jung-Rae
authors.initials: JR
authors.lastname: Rho
mesh_terms: D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005618:Fresh Water / Q000382:microbiology; D015394:Molecular Structure; D014361:Trypsin Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D047630:Depsipeptides; D014361:Trypsin Inhibitors; C531494:cyanopeptolin CB071