Microalbuminuria in systolic and diastolic chronic heart failure patients.
BACKGROUND
Microalbuminuria is considered a major risk factor predisposing to cardiovascular morbidity and mortality. Microalbuminuria levels in patients with or without diabetes have been associated with a higher risk of chronic heart failure (HF). However, there are limited data regarding prevalence of microalbuminuria in chronic heart failure and its prognostic value. The aim of this study was to assess the occurrence of microalbuminuria in chronic heart failure patients as well as its association with clinical, echocardiographic, and body composition markers.


METHODS
In a cross-sectional study, we included 72 chronic heart failure patients (NYHA I-III) on standard HF therapy. All patients had an echocardiogram and body composition by vector bioelectric impedance analysis (measured by Body Stat Quad Scan).


RESULTS
The studied population consisted of 64% men at mean age of 62.6 +/- 15.1 years. Patients were divided into systolic and diastolic HF groups. Microalbuminuria was observed in 40% of diastolic and 24% systolic HF patients (p = 0.04). Microalbuminuria was present in more patients with volume overload (80 vs. 21.9%, p = 0.002), with a worse phase angle and lower serum albumin (4.7 vs. 5.9 degrees and 3.5 vs. 4.0 mg/dl, p = 0.02) and higher pulmonary arterial pressure compared with patients without microalbuminuria in systolic HF patients. There was no significant association between frequency of microalbuminuria and ejection fraction. In the diastolic HF group, the presence of microalbuminuria was not associated with any known risk factor.


CONCLUSIONS
Microalbuminuria was more frequent in diastolic than systolic HF patients. In systolic HF patients microalbuminuria was associated with factors known to be markers of worse prognosis.
Orea-Tejeda
Arturo
A
Heart Failure Clinic Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México.
Colín-Ramírez
Eloisa
E
Hernández-Gilsoul
Thierry
T
Castillo-Martínez
Lilia
L
Abasta-Jiménez
Marcela
M
Asensio-Lafuente
Enrique
E
Narváez David
René
R
Dorantes-García
Joel
J
D000368:Aged; D000419:Albuminuria / Q000453:epidemiology*; D015415:Biomarkers; D001823:Body Composition; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D054144:Heart Failure, Diastolic / Q000000981:diagnostic imaging / Q000652:urine*; D054143:Heart Failure, Systolic / Q000000981:diagnostic imaging / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index
D015415:Biomarkers