title: Serum levels of adenosine deaminase and pregnancy-related hormones in hyperemesis gravidarum.
abstract: OBJECTIVE
  We investigated the correlation between pregnancy-related hormones and serum adenosine deaminase (indicator of cellular immunity) level in women with hyperemesis gravidarum.
  
  
  METHODS
  Twenty patients with hyperemesis gravidarum and 20 normal pregnancies were included in this prospective, case-control study. Serum adenosine deaminase levels, hematological parameters (white blood cells, neutrophil, monocyte and lymphocyte counts) and hormone levels (prolactin, progesterone, thyroid stimulating hormone, human chorionic gonadotropin beta subunit, estradiol (E2)) were measured in all women. Interrelations of blood cell counts and hormone levels with serum adenosine deaminase levels were also investigated.
  
  
  RESULTS
  Serum adenosine deaminase, human chorionic gonadotropin beta subunit, thyroid stimulating hormone, E2, progesterone and prolactin levels, and lymphocyte and monocyte counts in women with hyperemesis gravidarum were significantly higher than in controls but white blood cells, neutrophil, T3 and T4 levels were not different. Serum adenosine deaminase level correlated with E2, progesterone, lymphocyte, and monocyte levels for all patients.
  
  
  CONCLUSIONS
  Elevated serum adenosine deaminase in patients with hyperemesis gravidarum may relate to high levels of E2 and progesterone.
authors.affiliation: Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey. salihtaskin@yahoo.com
authors.forename: Salih
authors.initials: S
authors.lastname: Taşkin
authors.forename: Elif Aylin
authors.initials: EA
authors.lastname: Taşkin
authors.forename: Mehmet Murat
authors.initials: MM
authors.lastname: Seval
authors.forename: Cem Somer
authors.initials: CS
authors.lastname: Atabekoğlu
authors.forename: Bulent
authors.initials: B
authors.lastname: Berker
authors.forename: Feride
authors.initials: F
authors.lastname: Söylemez
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood* / Q000276:immunology; D007111:Immunity, Cellular; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D055815:Young Adult
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D011374:Progesterone; D004958:Estradiol; D000243:Adenosine Deaminase