Antifungal activity of micafungin against Candida and Aspergillus spp. isolated from pediatric patients in Japan.
The in vitro antifungal activities of micafungin in comparison to caspofungin, fluconazole, itraconazole, voriconazole, and amphotericin B were evaluated against 93 Candida and 23 Aspergillus isolates recovered from pediatric patients with fungal infections. MICs were determined by the CLSI M27-A2 and M38-A for Candida and Aspergillus species, respectively. Micafungin showed potent activity against Candida albicans, Candida tropicalis, and Candida glabrata with a MIC range of <= 0.002 to 0.015mug/ml. In contrast, micafungin demonstrated higher MIC levels against Candida parapsilosis with a MIC range of 0.12 to 2 mug/ml. Micafungin showed potent antifungal activity against Aspergillus species tested with a MIC range of 0.004 to 0.015 mug/ml. Overall, micafungin had excellent in vitro antifungal activities against Candida and Aspergillus species recovered from pediatric patients with fungal infections.
Ikeda
Fumiaki
F
Chemotherapy Division, Mitsubishi Chemical Medience Corporation, Tokyo. mbc-ka@sa2.so-net.ne.jp
Saika
Takeshi
T
Sato
Yumie
Y
Suzuki
Makoto
M
Hasegawa
Miyuki
M
Mikawa
Takashi
T
Kobayashi
Intetsu
I
Tsuji
Akiyoshi
A
D000293:Adolescent; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000382:microbiology; D001230:Aspergillus / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan; D055666:Lipopeptides / Q000494:pharmacology*; D008297:Male; D000077551:Micafungin; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin