title: Differential modulation of inflammatory pain by a selective estrogen receptor beta agonist.
abstract: To understand the contribution of the estrogen receptor beta, the potent and selective agonist ERb-131 was evaluated in animal models of inflammatory pain. In paradigms of acute and persistent inflammatory pain, ERb-131 did not alleviate the nociception induced by either carrageenan or formalin. However, in the chronic complete Freund's adjuvant model, ERb-131 resolved both inflammatory and hyperalgesic components. Thus, ERb-131 is sufficient to alleviate chronic but not acute inflammatory pain states.
authors.affiliation: ACADIA Pharmaceuticals Inc, San Diego, CA, USA.
authors.forename: Luis R
authors.initials: LR
authors.lastname: Gardell
authors.forename: Lene
authors.initials: L
authors.lastname: Hyldtoft
authors.forename: Andria L
authors.initials: AL
authors.lastname: Del Tredici
authors.forename: Carsten B
authors.initials: CB
authors.lastname: Andersen
authors.forename: Luke C
authors.initials: LC
authors.lastname: Fairbairn
authors.forename: Birgitte W
authors.initials: BW
authors.lastname: Lund
authors.forename: Magnus
authors.initials: M
authors.lastname: Gustafsson
authors.forename: Mark R
authors.initials: MR
authors.lastname: Brann
authors.forename: Roger
authors.initials: R
authors.lastname: Olsson
authors.forename: Fabrice
authors.initials: F
authors.lastname: Piu
mesh_terms: D000208:Acute Disease; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D002908:Chronic Disease; D047629:Estrogen Receptor beta / Q000819:agonists*; D005557:Formaldehyde; D005620:Freund's Adjuvant; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D047629:Estrogen Receptor beta; D005557:Formaldehyde; D002351:Carrageenan; D005620:Freund's Adjuvant