Beyond prostaglandins--chemistry and biology of cyclic oxygenated metabolites formed by free-radical pathways from polyunsaturated fatty acids.
Polyunsaturated fatty acids (PUFAs) are important constituents in all organisms. They fulfil many functions, ranging from modulating the structure of membranes to acting as precursors of physiologically important molecules, such as the prostaglandins, which for a long time were the most prominent cyclic PUFA metabolites. However, since the beginning of the 1990s a large variety of cyclic metabolites have been discovered that form under autoxidative conditions in vivo to a much larger extent than do prostaglandins. These compounds--isoprostanes, neuroprostanes, phytoprostanes, and isofurans--proved subsequently to be ubiquitous in nature. They display a wide range of biological activities, and isoprostanes have become the currently most reliable indicators of oxidative stress in humans. In a relatively short time, the structural variety, properties, and applications of the autoxidatively formed cyclic PUFA derivatives have been uncovered.
Jahn
Ullrich
U
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo namesti 2, 16610 Prague 6, Czech Republic. jahn@uochb.cas.cz
Galano
Jean-Marie
JM
Durand
Thierry
T
D003516:Cycloparaffins; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D011453:Prostaglandins
D003516:Cycloparaffins; D005231:Fatty Acids, Unsaturated; D005609:Free Radicals; D011453:Prostaglandins