Conformational changes of prion protein and nucleic acid arising from their interaction and relation of the altered structures in causing prion disease.
Nucleic acids catalyse the conversion of alpha-helical prion protein to the beta-structured protein oligomers and amyloids structurally similar to the infectious isoform of protein. Simultaneously, the prion protein, similar to gene regulating proteins, bends, unwinds and condenses nucleic acid. These properties might be related to the biological function and prion infection.
Nandi
P K
PK
Infectiologie Animale et Santé Publique, Institut National de la Recherche Agronomique, 37380 Nouzilly, France. nandi@tours.inra.fr
D000818:Animals; D006801:Humans; D008968:Molecular Conformation; D009696:Nucleic Acids / Q000737:chemistry* / Q000235:genetics*; D017096:Prion Diseases / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy; D011328:Prions / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding
D009696:Nucleic Acids; D011328:Prions