title: Three new compounds from Kadsura longipedunculata.
abstract: Two new tetrahydrofuran lignans, kadlongirins A and B (1, 2), a new cadinane-type sesquiterpenoid, 2,7-dihydroxy-11,12-dehydrocalamenene (3), together with seven known lignans, grandisin, fragransin B1, vladirol F, kadsuralignan C, otobaphenol, isoanwulignan, and 4-[4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-2-methoxy-phenol, were isolated from the leaves and stems of Kadsura longipedunculata. The structures of these new compounds were elucidated by spectroscopic methods. Compound 2 exhibited weak anti-human immunodeficiency virus-1 activity with an EC50 value of 16.0 microg/ml, and therapeutic index (TI) value of 6.7.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Gao
authors.forename: Chun
authors.initials: C
authors.lastname: Lei
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Rui-Rui
authors.initials: RR
authors.lastname: Wang
authors.forename: Li-Bin
authors.initials: LB
authors.lastname: Yang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Li
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D019380:Anti-HIV Agents / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D008517:Phytotherapy; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C531489:2,7-dihydroxy-11,12-dehydrocalamenene; D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D005663:Furans; D017705:Lignans; D012717:Sesquiterpenes; C531870:kadlongirin A; C018674:tetrahydrofuran; C074346:grandisin