title: Diazinium salts with dihydroxyacetophenone skeleton: Syntheses and antimicrobial activity.
abstract: Herein we report a feasible study concerning syntheses, structure and antimicrobial activity of some new diazinium salts with dihydroxyacetophenone skeleton. A fast, general, environmentally friendly, and facile method for preparation of diazinium salts under microwave and ultrasounds irradiation is presented. Antimicrobial tests prove that some diazine compounds have a remarkable activity against different microorganisms (germs and fungi), the pyrimidine derivatives being more active. Correlations between structure and antimicrobial activity are reported.
authors.affiliation: "Al. I. Cuza" University of Iasi, Organic and Biochemistry Department, Bd. Carol 11, 700506 Iasi, Romania.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Balan
authors.forename: Ondina
authors.initials: O
authors.lastname: Florea
authors.forename: Costel
authors.initials: C
authors.lastname: Moldoveanu
authors.forename: Gheorghita
authors.initials: G
authors.lastname: Zbancioc
authors.forename: Dorina
authors.initials: D
authors.lastname: Iurea
authors.forename: Ionel I
authors.initials: II
authors.lastname: Mangalagiu
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005240:Feasibility Studies; D055772:Green Chemistry Technology; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D013329:Structure-Activity Relationship
chemical_list: D000098:Acetophenones; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; C019339:2,6-dihydroxyacetophenone