The prevalence of Th17 cells in patients with gastric cancer.
Th17 cells have emerged as an important mediator in inflammatory and autoimmune diseases. However, recent studies suggest a potential impact of Th17 cells on tumor. The current study was designed to investigate the possible involvement of Th17 cells in gastric cancer. Compared with healthy volunteers, patients with gastric cancer had a higher proportion of Th17 cells in peripheral blood. Notably, the increased prevalence of Th17 cells was associated with clinical stage. In addition, increased populations of Th17 cells were present in tumor-draining lymph nodes with advanced disease. Furthermore, the mRNA expression levels of Th17-related factors (IL-17, IL-23p19, and RORC) in tumor tissues and the serum concentrations of IL-17 and IL-23 cytokines were significantly increased in patients with advanced gastric cancer. The results indicate that Th17 cells may contribute to gastric cancer pathogenesis.
Zhang
Bin
B
Department of General Surgery, Changhai Hospital, The Second Military Medical University, No. 168, Changhai Road, Shanghai 200433, PR China.
Rong
Guanghua
G
Wei
Huafeng
H
Zhang
Meng
M
Bi
Jianwei
J
Ma
Liye
L
Xue
Xuchao
X
Wei
Guo
G
Liu
Xiaokang
X
Fang
Guoen
G
D000368:Aged; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D053760:Interleukin-23 Subunit p19 / Q000097:blood / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism; D013274:Stomach Neoplasms / Q000276:immunology* / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D020381:Interleukin-17; D053760:Interleukin-23 Subunit p19; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear