[C-type natriuretic peptide and injured vascular diseases].
C-type natriuretic peptide (CNP) is a member of Natriuretic peptides family which is synthesized and secreted by vascular endothelial cells. CNP can bind with specific G-protein coupling receptor -natriuretic peptide receptor-B (NPR-B) and elevate cellular cGMP level by activating guanylate cyclase. CNP regulates homeostasis of circulating system in an autocrine/paracrine manner. Vascular system, especially endothelium, is rich in CNP and its receptor. CNP exerts natriuretic and natriuretic effect and regulates vessel tone, inhibits migration and proliferation of vascular smooth muscle cell. CNP is tightly correlated with injured vascular diseases such as hypertension, atherosclerosis, thrombogenesis, restenosis and vascular calcification.
Chen
Jing-Jing
JJ
Institute of Cardiovascular Disease, Faculty of Medicine, University of South China, Hengyang 421001, China.
Qi
Yong-Fen
YF
Jiang
Zhi-Sheng
ZS
D000818:Animals; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D020098:Natriuretic Peptide, C-Type / Q000378:metabolism; D061205:Vascular Calcification / Q000378:metabolism; D014652:Vascular Diseases / Q000378:metabolism
D020098:Natriuretic Peptide, C-Type