Increasing chiral recognition in acetal formation.
The design of substituted lactols is described, which in their reaction with racemic alkyl aryl carbinols react preferentially with one of the enantiomers exhibiting selectivities up to 14:1.
Noe
Christian R
CR
Department of Medicinal Chemistry, University of Vienna, Vienna, Austria. christian.noe@univie.ac.at
Knollmüller
Max
M
Jangg
Edith
E
Gmeiner
Günter P
GP
Urban
Ernst
E
Eppacher
Simon
S
D000080:Acetals / Q000737:chemistry*; D002621:Chemistry / Q000379:methods*; D002625:Chemistry, Organic / Q000379:methods*; D005947:Glucose / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D008024:Ligands; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry
D000080:Acetals; D007783:Lactones; D008024:Ligands; D013449:Sulfonamides; D005947:Glucose