Organic cation transporters.
1. Organic cation transporters (OCTs) translocate endogenous (e.g. dopamine) and exogenous (e.g. drugs) substances of cationic nature and, therefore, play an important role in the detoxification of exogenous compounds. This review aims to furnish essential information on OCTs, with an emphasis on pharmacological aspects. 2. Analysis of the literature on OCTs makes clear that there is a species- and organ-specific distribution of the different isoforms, which can also be differentially regulated. OCTs are responsible for the excretion and/or distribution of many drugs and also for serious tissue-specific side-effects such as cisplatin-induced nephrotoxicity. The presence of single nucleotide polymorphisms in these transporters significantly influences the response of patients to medication, as demonstrated for the antidiabetic drug metformin. 3. A substantial amount of research has to be undertaken to clarify further the OCT structure-function relationships specifically to define the role of oligomerization on their activity and regulation, to identify intracellular interaction partners of OCTs, and to characterize their pharmacogenetic aspects.
Ciarimboli
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Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, Germany. shufeng.zhou@rmit.edu.au
D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D002945:Cisplatin / Q000493:pharmacokinetics*; D006801:Humans; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics*; D017136:Ion Transport / Q000187:drug effects / Q000235:genetics; D008687:Metformin / Q000493:pharmacokinetics*; D009928:Organ Specificity / Q000187:drug effects / Q000235:genetics; D027701:Organic Cation Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D007004:Hypoglycemic Agents; D027701:Organic Cation Transport Proteins; D020033:Protein Isoforms; D008687:Metformin; D002945:Cisplatin