Lignans and other constituents of the fruits of Euterpe oleracea (Acai) with antioxidant and cytoprotective activities.
Using a hydroxyl radical scavenging assay, bioactivity-guided fractionation of a methanol-soluble extract of the fruits of Euterpe oleracea (acai) led to the isolation of 22 compounds of previously known structure. Altogether, 14 of these isolates were found to be active in an in vitro hydroxyl radical scavenging assay and seven of these isolates in a 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. Dihydroconiferyl alcohol, (+)-lariciresinol, (+)-pinoresinol, (+)-syringaresinol, and protocatechuic acid methyl ester exhibited cytoprotective activity in cultured MCF-7 cells stressed by H2O2. Lignans have not been previously reported as constituents of this species and were found to be representative of the aryltetrahydronaphthalene, dihydrobenzofuran, furofuran, 8-O-4'-neolignan, and tetrahydrofuran structural types.
Chin
Young-Won
YW
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, Ohio 43210, USA.
Chai
Hee-Byung
HB
Keller
William J
WJ
Kinghorn
A Douglas
AD
D000975:Antioxidants / Q000494:pharmacology*; D028023:Arecaceae / Q000737:chemistry*; D002460:Cell Line; D019610:Cytoprotection; D016166:Free Radical Scavengers; D005638:Fruit / Q000737:chemistry*; D017665:Hydroxyl Radical; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology
D000975:Antioxidants; D016166:Free Radical Scavengers; D017705:Lignans; D010936:Plant Extracts; D017665:Hydroxyl Radical