Preferentially linear connection of gold nanoparticles in derivatization with phosphorothioate oligonucleotides.
A gold nanosphere in water is considered to attain special stability in derivatization like an artificial atom when the octet rule is satisfied by forming four covalent bonds with two 5'-phosphorothioate-modified oligonucleotide molecules. Owing to this, the hybridization of two mutually complementary gold-bound oligonucleotides makes gold nanospheres preferentially connected linearly by duplexes to produce strands like linear artificial molecules. We have then fixated the linear strands of DNA-linked gold nanospheres by reducing Ag(+) ion clusters immobilized around duplexes to show the absorption spectrum of silver-coated artificial-molecular nanorods.
Kim
Jong-Yeob
JY
School of Chemistry and Center for Space-Time Molecular Dynamics, Seoul National University, NS60, Seoul 151-742, South Korea.
Lee
Dong Hun
DH
Kim
Seol Ji
SJ
Jang
Du-Jeon
DJ
D002412:Cations / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry; D009693:Nucleic Acid Hybridization / Q000379:methods*; D054735:Phosphorothioate Oligonucleotides / Q000737:chemistry*; D012834:Silver / Q000737:chemistry; D013057:Spectrum Analysis
D002412:Cations; D054735:Phosphorothioate Oligonucleotides; D012834:Silver; D006046:Gold; D004247:DNA