Donor safety and remnant liver volume in living donor liver transplantation.
Living donor liver transplantation is now a common practice in countries in which the availability of cadaveric organs is limited. The preoperative preparation, intraoperative surgical technique, and postoperative care of donors and recipients have evolved in recent years. We retrospectively compared 67 donors with a remnant liver volume equal to or more than 30% (group 1) with 14 donors who had less than 30% remnant liver volume (group 2) for donor outcomes. All the complications in donors were systematically classified. Donors with less than 30% remnant liver volume showed significantly higher peak aspartate aminotransferase, alanine aminotransferase, international normalized ratio, and bilirubin levels. There were 6 complications in group 1 and 4 complications in group 2. The difference between the 2 groups in terms of donor complications did reach statistical significance (P = 0.043); donors with a remnant liver volume < 30% had a 4 times greater relative risk of morbidity. In conclusion, the use of donors with less than 30% remnant liver volume is highly debatable as donor safety should be of utmost importance in living donor liver transplantation.
Taner
C Burcin
CB
Department of Surgery and Transplantation, Florence Nightingale Hospital, Istanbul Science University, Istanbul, Turkey. tanerburcin@yahoo.com
Dayangac
Murat
M
Akin
Baris
B
Balci
Deniz
D
Uraz
Suleyman
S
Duran
Cihan
C
Killi
Refik
R
Ayanoglu
Omer
O
Yuzer
Yildiray
Y
Tokat
Yaman
Y
D000328:Adult; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000473:pathology*; D016031:Liver Transplantation / Q000473:pathology*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012189:Retrospective Studies; D020858:Tissue and Organ Harvesting / Q000009:adverse effects*