Studies directed toward the development of amide-linked RNA mimics: synthesis of the monomeric building blocks.
A general approach toward the synthesis of all four monomeric building blocks of the ribonucleoside amino acids 3'-amino-5'-carboxymethyl-3',5'-dideoxy nucleosides in their protected forms is described that will facilitate the development of amide-linked RNA mimics.
Chakraborty
Tushar Kanti
TK
Indian Institute of Chemical Technology, Hyderabad 500 007, India. chakraborty@iict.res.in
Gajula
Praveen Kumar
PK
Koley
Dipankar
D
D000577:Amides / Q000737:chemistry*; D008956:Models, Chemical; D018716:Molecular Mimicry; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis*; D012313:RNA / Q000737:chemistry*; D012263:Ribonucleosides / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000577:Amides; D020135:Peptide Nucleic Acids; D012263:Ribonucleosides; D012313:RNA