Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer.
A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible "cage" that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.
Cheng
Yu
Y
Center for Chemical Dynamics and Nanomaterials Research, Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA.
C Samia
Anna
A
Meyers
Joseph D
JD
Panagopoulos
Irene
I
Fei
Baowei
B
Burda
Clemens
C
D000818:Animals; D016503:Drug Delivery Systems; D006046:Gold / Q000737:chemistry*; D007211:Indoles / Q000008:administration & dosage* / Q000737:chemistry; D054833:Isoindoles; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D011092:Polyethylene Glycols / Q000737:chemistry; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry; D026082:Singlet Oxygen / Q000032:analysis; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
D007211:Indoles; D054833:Isoindoles; D011838:Radiation-Sensitizing Agents; D026082:Singlet Oxygen; D011092:Polyethylene Glycols; D006046:Gold; C013647:phthalocyanine