A new indole alkaloid and anti-inflammatory constituents from Strychnos cathayensis.
A new indole alkaloid, 11,12-dimethoxyhenningsamine, was isolated from the roots of Strychnos cathayensis, together with 19 known compounds. The structure of this new compound was determined through spectroscopic and mass-spectrometric analyses. Among the isolated compounds, 11-methoxyhenningsamine and aesculetin dimethyl ether exhibited potent inhibition (IC(50) < 5.5 microg/ml) on superoxide-anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/cytochalasin B.
Chen
Jih-Jung
JJ
Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan. jjchen@mail.tajen.edu.tw
Luo
Yu-Ting
YT
Hwang
Tsong-Long
TL
Sung
Ping-Jyun
PJ
Wang
Tai-Chi
TC
Chen
Ih-Sheng
IS
D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D031451:Strychnos / Q000737:chemistry*; D013481:Superoxides / Q000378:metabolism
C531472:11,12-dimethoxyhenningsamine; D000893:Anti-Inflammatory Agents; D026121:Indole Alkaloids; D013481:Superoxides