title: Pyridoxal plasma level in schizophrenic and schizoaffective patients with and without tardive dyskinesia.
abstract: BACKGROUND
  Motor disturbances in vitamin B6-deficient animals were described. Some clinical experiments showed that vitamin B6 may ameliorate different drug-induced movement disorders, including tardive dyskinesia (TD). The aim of this study was to compare plasma pyridoxal-5-phosphate (PLP) levels in schizophrenic patients with and without TD.
  
  
  METHODS
  This study was conducted in the Be'er Sheva Mental Health Center from February 2006 to August 2006. Eighty-nine schizophrenic inpatients (40 have TD, 22 men and 18 women, 20-66 yrs old [mean, 48 yrs] and 49 schizophrenic inpatients, 30 men and 19 women, 21-66 yrs old (mean, 49 yrs), without any symptoms of motor disturbances [the control group]) were enrolled in the study. Measurement of PLP is performed by high-performance liquid chromatography separation in all patients.
  
  
  RESULTS
  There was a significant difference in plasma PLP levels between patients with TD and those without TD. The discrepancy between the groups was almost entirely attributable to the PLP levels of male patients: 12.4 +/- 11.4 vs 29.0 +/- 12.9 nM in men (P < 0.001), and 19.7 +/- 14.8 vs 22.0 +/- 13.6 nM in women (P > 0.5).
  
  
  CONCLUSIONS
  Our results suggest that schizophrenic and schizoaffective male patients with TD have lower PLP plasma levels than non-TD patients.
authors.affiliation: Division of Psychiatry, Ministry of Health Be'er Sheva Mental Health Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.
authors.forename: Chanoch
authors.initials: C
authors.lastname: Miodownik
authors.forename: Aviel
authors.initials: A
authors.lastname: Meoded
authors.forename: Igor
authors.initials: I
authors.lastname: Libov
authors.forename: Yuly
authors.initials: Y
authors.lastname: Bersudsky
authors.forename: Ben-Ami
authors.initials: BA
authors.lastname: Sela
authors.forename: Vladimir
authors.initials: V
authors.lastname: Lerner
mesh_terms: D000328:Adult; D000368:Aged; D004409:Dyskinesia, Drug-Induced / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000097:blood* / Q000150:complications; D011732:Pyridoxal Phosphate / Q000097:blood*; D012559:Schizophrenia / Q000097:blood* / Q000150:complications
chemical_list: D011732:Pyridoxal Phosphate