title: Interstitial high-dose-rate-brachytherapy in advanced esthesioneuroblastoma.
abstract: Esthesioneuroblastoma is a rare neuroectodermal tumor of the nasal vault with an aggressive biological behavior that is characterized by local recurrence, atypical distant metastasis, and poor long-term prognosis. The treatment regimen consists of surgical resection, radiation therapy, and chemotherapy in various, mainly stage-dependent, combinations. We report two cases of primary metastatic and locally recurrent disease, which were treated with computed tomography-guided interstitial high-dose-rate brachytherapy in palliative and curative intent, respectively. Computed tomography-guided interstitial high-dose-rate brachytherapy should be considered as a feasible treatment option for advanced esthesioneuroblastoma.
authors.affiliation: Department of Radiation Oncology, Klinikum Offenbach, Offenbach, Germany. ntselis@hotmail.com
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Tselis
authors.forename: Reinhard
authors.initials: R
authors.lastname: Heyd
authors.forename: Mehran
authors.initials: M
authors.lastname: Baghi
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Zamboglou
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D004307:Dose-Response Relationship, Radiation; D018304:Esthesioneuroblastoma, Olfactory / Q000175:diagnosis / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D014057:Tomography, X-Ray Computed