title: Herpes simplex virus type 1 DNA sequences are present in aged normal and Alzheimer's disease brain but absent in lymphocytes.
abstract: The etiology of Alzheimer's disease (AD) is unknown. Viruses have been suggested as a possible factor but the issue is still unresolved. We have detected herpes simplex virus type 1 DNA sequences in AD and normal brain, using polymerase chain reaction (PCR), and have now searched for the DNA in lymphocytes from AD patients and age-matched normal individuals; PCR shows that the virus is absent in the lymphocytes.
authors.affiliation: Molecular Neurobiology Laboratory, Department of Optometry and Vision Sciences, University of Manchester Institute of Science and Technology, P.O. Box 88, Manchester, M60 1QD, UK.
authors.forename: G A
authors.initials: GA
authors.lastname: Jamieson
authors.forename: N J
authors.initials: NJ
authors.lastname: Maitland
authors.forename: R F
authors.initials: RF
authors.lastname: Itzhaki