Tumour-targeted nanomedicines: principles and practice.
Drug targeting systems are nanometre-sized carrier materials designed for improving the biodistribution of systemically applied (chemo)therapeutics. Various different tumour-targeted nanomedicines have been evaluated over the years, and clear evidence is currently available for substantial improvement of the therapeutic index of anticancer agents. Here, we briefly summarise the most important targeting systems and strategies, and discuss recent advances and future directions in the development of tumour-targeted nanomedicines.
Lammers
T
T
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, Utrecht 3584 CA, The Netherlands.
Hennink
W E
WE
Storm
G
G
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D008081:Liposomes; D050997:Nanomedicine; D009369:Neoplasms / Q000188:drug therapy*; D011108:Polymers
D000970:Antineoplastic Agents; D008081:Liposomes; D011108:Polymers