The kinetics of hepatitis C virus-specific CD8 T-cell responses in the blood mirror those in the liver in acute hepatitis C virus infection.
Peripheral blood T-cell responses are used as biomarkers in hepatitis C virus (HCV) vaccine trials. However, it is not clear how T-cell responses in the blood correlate with those in the liver, the infection site. By studying serial liver and blood samples of five vaccinated and five mock-vaccinated control chimpanzees during acute HCV infection, we demonstrate a correlation between HCV-specific CD8 T-cell responses in the blood and molecular and functional markers of T-cell responses in the liver. Thus, HCV-specific CD8 T-cell responses in the blood are valid markers for intrahepatic T-cell activity.
Shin
Eui-Cheol
EC
Immunology Section, LDB, NIDDK, NIH, Bethesda, MD 20892-1800, USA.
Capone
Stefania
S
Cortese
Riccardo
R
Colloca
Stefano
S
Nicosia
Alfredo
A
Folgori
Antonella
A
Rehermann
Barbara
B
D000208:Acute Disease; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D016174:Hepacivirus / Q000378:metabolism*; D019698:Hepatitis C, Chronic / Q000276:immunology / Q000821:virology*; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D007371:Interferon-gamma / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000821:virology*; D002679:Pan troglodytes; D012333:RNA, Messenger / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism; D014765:Viral Vaccines
D012333:RNA, Messenger; D014765:Viral Vaccines; D007371:Interferon-gamma