Rational design and synthesis of 2,2-bisheterocycle tandem derivatives as non-nucleoside hepatitis B virus inhibitors.
Chen
Hai-Jun
HJ
Chinese National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, 189 Guo Shou Jing Road, Shanghai 201203, China. fjnan@mail.shcnc.ac.cn
Wang
Wen-Long
WL
Wang
Gui-Feng
GF
Shi
Li-Ping
LP
Gu
Min
M
Ren
Yu-Dan
YD
Hou
Li-Fei
LF
He
Pei-Lan
PL
Zhu
Feng-Hua
FH
Zhong
Xian-Gen
XG
Tang
Wei
W
Zuo
Jian-Ping
JP
Nan
Fa-Jun
FJ
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006515:Hepatitis B virus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D054852:Small Molecule Libraries; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017361:Viral Nonstructural Proteins / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D054852:Small Molecule Libraries; D013844:Thiazoles; D017361:Viral Nonstructural Proteins