(2+2) cycloaddition reaction of alkyl enol ethers with acrylates by in situ generated silyl triflic imide catalyst.
We describe here (2+2) cycloaddition reaction of alkyl enol ethers with acrylates catalyzed by triethylsilyl triflic imide (Et3SiNTf2), which was in situ generated from triethylsilane and triflic imide. The reaction efficiently provides substituted cyclobutanes bearing alkoxy function in a stereoselective manner.
Takasu
Kiyosei
K
Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan. kay-t@pharm.kyoto-u.ac.jp
Miyakawa
Yuta
Y
Ihara
Masataka
M
Tokuyama
Hidetoshi
H
D000179:Acrylates / Q000737:chemistry*; D002384:Catalysis; D004986:Ether / Q000737:chemistry; D004987:Ethers / Q000737:chemistry*; D007094:Imides / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D012821:Silanes / Q000737:chemistry
D000179:Acrylates; D004987:Ethers; D007094:Imides; D007659:Ketones; D012821:Silanes; D004986:Ether; C512918:triethylsilane