title: Carbamazepine overdose after exposure to simethicone: a case report.
abstract: BACKGROUND
  Carbamazepine is an anticonvulsant drug and is also used as a treatment for patients with manic-depressive illness, post-herpetic neuralgia or phantom limb pain. The drug itself has many drug interactions. Simethicone is an antifoaming agent and is reported to be an inert material with no known drug interaction with carbamazepine.
  
  
  METHODS
  We present a case of a patient who was routinely using carbamazepine 400 mg three times per day and levetiracetam 500 mg twice daily, and experienced carbamazepine overdose after exposure to simethicone. After cessation of simethicone therapy normal drug levels of carbamazepine were obtained again with the standard dose of the drug. The mechanism of interaction is unknown but the risk of overdose should be considered when prescribing simethicone to a patient who is using carbamazepine.
  
  
  CONCLUSIONS
  Simethicone and carbamazepine, when taken together, may be a cause of carbamazepine toxicity. The risk of carbamazepine overdose should be considered when prescribing simethicone to a patient who is using carbamazepine.
authors.affiliation: Marmara University, School of Medicine, Department of Emergency Medicine, Istanbul, Turkey. guneysel@gmail.com
authors.forename: Ozlem
authors.initials: O
authors.lastname: Guneysel
authors.forename: Ozge
authors.initials: O
authors.lastname: Onur
authors.forename: Arzu
authors.initials: A
authors.lastname: Denizbasi
authors.forename: Murat
authors.initials: M
authors.lastname: Saritemur