[Glycopolymers of microorganisms: molecular relationship between structure, function, and biological activity].
The results of the Department of Biochemistry investigations during the recent 5 years are presented. For the first time the structures of O-specific polysaccharides of lipopolysaccharides of representatives of Enterobacteriaceae new genus--Rahnella aquatilis have been established. The structures are represented by linear or branched mono-, tri- and hexasaccharides. As well as in other Enterobacteriaceae representatives only one hydrohylated acid--3-hydroxytetradecanoic has been established in lipids A of R. aquatilis. It was shown that toxicity and pyrogeneity of lipopolysaccharides R. aquatilis and Ralstonia solanacearum are due to the acyl-, phosphoryl- and free hydroxylic groups of lipids A. Physico-chemical properties and substrated specificity of enzymes-glycoproteins (alpha-L-rhmanosidase, a-N-acetylgalactosaminidase, collagenase and keratinase) have been studied. On the basis of the data concerning substrate specificity of the above enzymes the possible trends of their practical usage are considered.
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D000047:Academies and Institutes / Q000266:history; D006090:Gram-Negative Bacteria / Q000737:chemistry / Q000254:growth & development; D049673:History, 20th Century; D049674:History, 21st Century; D008070:Lipopolysaccharides / Q000737:chemistry / Q000266:history / Q000494:pharmacology; D008829:Microbiology / Q000266:history*; D012106:Research / Q000266:history; D014455:Ukraine
D008070:Lipopolysaccharides