title: [Morphological parameters of prostatic adenocarcinoma].
abstract: BACKGROUND
  Prostatic carcinoma is one of the most common malignancies in men and the second most common cause of cancer-related deaths, after lung cancer. However, many of these tumors are latent, of no biologic significance, and are recognized only as an incidental findig at autopsy.
  HISTOLOGIC FEATURES: Prostatic carcinomas have multiple histologic patterns, which can easily be confused with benign lesions. The following histologic changes are associated with prostatic carcinomas. prostatic acini are close to one another and present with linear infiltrates in the fibromuscular tissue; cells lining the acini often consist of a single layer, and the basal cell layer is absent; prominent large eosinophilic nucleoli are usually present in malignant cells; nuclear hyperchromatism is rare and it depends on the quality of the tissue fixation; perineural invasion is often observed. Today, the Gleason grading system is the most commonly used (Gleason score). Immunohistochemistry is widely used in pathology and clinical diagnosis of prostatic carcinoma, metastases of prostatic origin in staging malignant tumors and in the prognosis.
authors.affiliation: Institut za patologiju i histologiju, Medicinski fakultet Novi Sad, Klinicki centar Vojvodine. sanapat@eunet.yu
authors.forename: Sandra
authors.initials: S
authors.lastname: Trivunić
authors.forename: Pavle
authors.initials: P
authors.lastname: Budakov
authors.forename: Nada
authors.initials: N
authors.lastname: Vucković
authors.forename: Mirjana
authors.initials: M
authors.lastname: Zivojinov
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology*