Remarkable DNA binding affinity and potential anticancer activity of pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide conjugates linked through piperazine side-armed alkane spacers.
A series of pyrrolobenzodiazepine-naphthalimide conjugates tethered through a piperazine ring system have been designed, synthesized, and evaluated for their anticancer activity. These new conjugates exhibit very high DNA binding affinity and cytotoxic activity against a number of cell lines.
Kamal
Ahmed
A
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India. ahmedkamal@iict.res.in
Ramu
R
R
Tekumalla
Venkatesh
V
Khanna
G B Ramesh
GB
Barkume
Madan S
MS
Juvekar
Aarti S
AS
Zingde
Surekha M
SM
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D053644:Naphthalimides / Q000737:chemistry* / Q000494:pharmacology*; D009691:Nucleic Acid Denaturation; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D053644:Naphthalimides; D004247:DNA