Biological activity of amide derivatives of lysine.
Five substituted amides of lysine with the general formula: X-Lys-NH-Y, where X= acetyl or ethoxycarbonyl, Y= cyclohexyl, benzyl, hexyl or cadaverine residue were synthesised and their effects on fibrinolytic activity of plasmin, clotting activity of thrombin and amidolytic activities of both enzymes were examined.
Midura-Nowaczek
Krystyna
K
Department of Organic Chemistry, Medical University of Białystok, Białystok, Poland. kmidura@amb.edu.pl
Lepietuszko
Izabela
I
Bruzgo
Irena
I
Markowska
Agnieszka
A
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D005342:Fibrinolysis / Q000187:drug effects / Q000502:physiology; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors*
D000577:Amides; D013917:Thrombin; D005341:Fibrinolysin; D008239:Lysine