Study of wound healing in rats treated with topical and injected mitomycin-C.
Experimental study in animals.


BACKGROUND
Mitomycin C has been used as a fibroblasts inhibitor, thus reducing the scaring process in surgical wounds.


OBJECTIVE
This paper aims at assessing the use of Mitomycin C to reduce the scaring process through its topical use and later injected reinforcements.


METHODS
We used a model of a creating a wound in the dorsum of rats, removing a circular piece of skin and letting it heal by itself. We used 18 rats, divided in three groups. The first group - Control, the second with topical use, and a third group with injected mitomycin C reinforcement, monthly for 2 months. After 3 months the animals were slaughtered and the scars were surgically removed and sent for histology study.


RESULTS
We noticed, under different criteria, that healing with topical mitomycin is less intense; however, when it was injected, the parameters were again comparable to those from the control group.


CONCLUSIONS
We believe that injected mitomycin C in the scar, since it is highly toxic, it destroys tissue and brings about scar neoformation.


CONCLUSIONS
Mitomycin C reduces the scaring process when used topically; however, it increases scar tissue formation when injected in these wounds.
Quintanilha Ribeiro
Fernando de Andrade
Fde A
Otorhinolaryngology Department, Faculdade de Ciências Médicas, Santa Casa de São Paulo, Brazil.
Borges
Janaína de Pádua
Jde P
Guaraldo
Lusiele
L
Vianna
Maria Regina
MR
D000287:Administration, Topical; D000477:Alkylating Agents / Q000008:administration & dosage*; D000818:Animals; D005347:Fibroblasts / Q000187:drug effects*; D005355:Fibrosis / Q000517:prevention & control; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D000477:Alkylating Agents; D016685:Mitomycin