Morphological manifestations for the protective effect of miliacin in organs of immunogenesis after treatment with methotrexate.
Morphological changes in lymphoid organs induced by antitumor drug methotrexate were studied in 219 male (CBAxC57B1/6)F1 mice. Plant triterpenoid miliacin attenuated the lymphotoxic effect of this drug.
Zheleznova
A D
AD
Orenburg State Medical Academy.
Zheleznov
L M
LM
Shtil
A A
AA
Frolov
B A
BA
D000818:Animals; D002452:Cell Count; D006965:Hyperplasia; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009929:Organ Size / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D014315:Triterpenes / Q000494:pharmacology*
D020011:Protective Agents; D014315:Triterpenes; C031972:miliacin; D008727:Methotrexate