Taurine in plasma and CSF: a study in healthy male volunteers.
In order to explore the interrelationship between plasma and cerebrospinal fluid taurine concentrations, three consecutive 6-ml fractions of cerebrospinal fluid were drawn from 30 healthy male volunteers in the early morning after 8 h in the fasting condition. Repeated plasma samples were drawn over 24 h the day before lumbar puncture. Taurine in plasma and cerebrospinal fluid was determined by high performance liquid chromatography. The subjects were categorized as extensive or poor metabolizers with respect to the cytochrome P450 2D6 genotype. The taurine cerebrospinal fluid/plasma ratio at 8 a.m. was negatively influenced by the plasma taurine concentration at 4 p.m. the previous day. It was also negatively influenced by body mass index and positively by the intraspinal pressure. Three poor metabolizers of cytochrome P450 2D6 had higher plasma taurine areas under the curve than 27 extensive metabolizers. Hypothetically, cytochrome P450 2D6 influences the transport of taurine across the blood-brain barrier.
Samuelsson
M
M
Faculty of Health Sciences, Department of Clinical and Experimental Medicine, Psychiatry Section, Linköping University, 581 85 Linköping, Sweden. martin.samuelsson@inr.liu.se
Dahl
M-L
ML
Gupta
R C
RC
Nordin
C
C
D000328:Adult; D000483:Alleles; D001812:Blood-Brain Barrier / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics / Q000378:metabolism*; D005838:Genotype; D006801:Humans; D008297:Male; D011795:Surveys and Questionnaires; D013654:Taurine / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000378:metabolism
D013654:Taurine; D019389:Cytochrome P-450 CYP2D6