[Effects of zingerone on fat storage in ovariectomized rats].
We reported that ginger prevented obesity in mice fed a high-fat diet in previous study. In this experiment, we examined the effects of zingerone, the major pungent component of ginger on fat storage in ovariectomized (Ovx) rats. Oral administration of 170 mg/kg zingerone significantly reduced body weight and the final parametrail adipose tissue weight in ovariectomized rats. Blood glucose levels after oral administration of glucose were lower in zingerone-treated Ovx-rats than in the Ovx-rats (control). Basal lipolysis in zingerone-treated Ovx-rats was increased compared with that in the Ovx-rats. Zingerone significantly increased norepinephrine-induced lipolysis associated with the translocation of hormone-sensitive lipase (HSL) from the cytosol to lipid droplets in adipocytes. These results indicate that zingerone may prevent the fat storage through increasing norepinephrine-induced lipolysis in adipocytes.
Han
Li-Kun
LK
R&D Laboratory, Kracie Holdings Ltd, Tokyo, Japan. r.han@khp.kracie.co.jp
Morimoto
Chie
C
Zheng
Yi-Nan
YN
Li
Wei
W
Asami
Etsuko
E
Okuda
Hiromichi
H
Saito
Masato
M
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects*; D008066:Lipolysis / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D002787:Sterol Esterase / Q000378:metabolism
D001786:Blood Glucose; C013738:zingerone; D006139:Guaiacol; D002787:Sterol Esterase; D009638:Norepinephrine