Breeding for scrapie resistance in the Hungarian sheep population.
The first results of the Hungarian sheep prion protein (PrP) genotyping programme are discussed in this paper. To obtain initial genotype frequency data 10 commercial (Hungarian Merino, German Mutton Merino, Merino Landschaf, German Blackheaded, Suffolk, Texel, Ile de France, Charollais, Lacaune, British Milksheep) and 4 indigenous (Gyimes Racka, Hortobágy Racka, Tsigaja, Cikta) breeds were sampled in 2003 and 2004, and the PrP genotypes were determined by microsequencing analysis with capillary electrophoresis. In all commercial breeds, a higher number of sheep were genotyped in 2005 (3648) and in 2006 (3834) within the breeding programme to increase scrapie resistance, and the estimated frequency data were compared to the initial figures to evaluate the efficiency of selection. The new developments arising from the identification of the so-called 'atypical' scrapie cases are also discussed.
Fésüs
László
L
Research Institute for Animal Breeding and Nutrition, H-2053 Herceghalom, Hungary. laszlo.fesus@atk.hu
Zsolnai
Attila
A
Anton
István
I
Sáfár
László
L
D000818:Animals; D001947:Breeding; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D008297:Male; D016133:Polymerase Chain Reaction; D011328:Prions / Q000235:genetics*; D012608:Scrapie / Q000235:genetics* / Q000517:prevention & control; D017422:Sequence Analysis, DNA; D012756:Sheep / Q000235:genetics*
D011328:Prions; D004247:DNA