title: Postcataract surgery outcome in a series of infants and children with Down syndrome.
abstract: OBJECTIVE
  To report the visual and refractive outcome and complications in children with Down syndrome undergoing cataract extraction.
  
  
  METHODS
  The case notes of 18 infants and children with lens opacities and Down syndrome who underwent cataract extraction between January 1981 and August 2006 were reviewed.
  
  
  RESULTS
  Over the 25-year study period, 7% (33 eyes) of paediatric eyes undergoing cataract extraction had Down syndrome. The average follow-up time was 11.2 (SD 7.5) years with a range of 2.5 months to 25 years. 25 were congenital, and eight were developmental lens opacities. 40% of patients attained a postoperative BCVA between 6/9 and 6/18. There was a large myopic shift of -7.96 (4.7) D for aphakes and -8.06 (7.4) D for pseudophakes with an average increase in axial length of 3.58 (3.14) mm. There was a 30% incidence of posterior capsular opacification (PCO) overall, 38% in eyes without a primary posterior capsulotomy. Five eyes developed aphakic glaucoma, one eventually necessitating an enucleation. Two patients had retinal detachments on follow-up.
  
  
  CONCLUSIONS
  Cataract extraction in our population of children with Down syndrome is a safe and effective procedure with a very encouraging visual outcome.
authors.affiliation: The Children's University Hospital, Temple Street, Dublin 1, Ireland.
authors.forename: C
authors.initials: C
authors.lastname: Gardiner
authors.forename: B
authors.initials: B
authors.lastname: Lanigan
authors.forename: M
authors.initials: M
authors.lastname: O'Keefe
mesh_terms: D002386:Cataract / Q000151:congenital / Q000473:pathology; D002387:Cataract Extraction / Q000009:adverse effects / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000209:etiology; D006801:Humans; D008297:Male; D009216:Myopia / Q000209:etiology; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity