title: Antimicrobial activity of 2,4-dihydro-[1,2,4]triazol-3-one derivatives.
abstract: Antibacterial and antifungal activity of 2,4-dihydro- [1,2,4]triazol-3-one derivatives were examined by the disc-diffusion method (growth inhibition zone diameter in agar medium). The MIC's for the most active agents were determined. Of all the tested compounds, aminomethyl derivatives of 2,4-dihydro-[1,2,4]triazol-3-one exhibit activity against the majority of microorganisms studied.
authors.affiliation: Department of Pharmaceutical Microbiology, Medical University, Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Stefańska
authors.forename: Marta
authors.initials: M
authors.lastname: Struga
authors.forename: Stefan
authors.initials: S
authors.lastname: Tyski
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kossakowski
authors.forename: Maria
authors.initials: M
authors.lastname: Dobosz
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D052978:Disk Diffusion Antimicrobial Tests; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*; D015003:Yeasts / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D014230:Triazoles