title: JAZ repressors set the rhythm in jasmonate signaling.
abstract: Jasmonates (JAs) are essential hormones for plant defense and development. In spite of their importance, the molecular details of their signaling pathways remain largely unknown. A new family of regulators of JA signaling named JAZ, jasmonate ZIM-domain proteins, has recently been described. JAZ proteins repress of JA signaling and are targeted by the E3-ubiquitin ligase SCF(COI1) for proteasome degradation in response to JA. Hormone binding depends on a functional COI1 protein suggesting that COI1 is the JA receptor. MYC2, a positive regulator of JA-dependent responses, has been identified as a target of JAZ repressors. Interestingly, MYC2 and JAZ proteins are involved in a negative regulatory feedback loop, suggesting a model to explain how transcriptional reprogramming is turned on and off in response to JA. The discovery of JAZ repressors provides a new framework to understand JA-signaling pathways from hormonal perception to transcriptional activation.
authors.affiliation: Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología-CSIC, Campus Universidad Autónoma, 28049 Madrid, Spain.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Chico
authors.forename: Andrea
authors.initials: A
authors.lastname: Chini
authors.forename: Sandra
authors.initials: S
authors.lastname: Fonseca
authors.forename: Roberto
authors.initials: R
authors.lastname: Solano
mesh_terms: D020816:Amino Acid Motifs; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000378:metabolism; D003517:Cyclopentanes / Q000378:metabolism*; D025461:Feedback, Physiological; D008954:Models, Biological; D005810:Multigene Family; D054883:Oxylipins / Q000378:metabolism*; D010802:Phylogeny; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D044843:SKP Cullin F-Box Protein Ligases / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D029681:Arabidopsis Proteins; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; C112279:COI1 protein, Arabidopsis; D003517:Cyclopentanes; C473611:MYC2 protein, Arabidopsis; D054883:Oxylipins; D012097:Repressor Proteins; C011006:jasmonic acid; D044843:SKP Cullin F-Box Protein Ligases; D046988:Proteasome Endopeptidase Complex