Asymmetric synthesis of (+)-isofebrifugine and (-)-sedacryptine from a common chiral nonracemic building block.
The stereoselective syntheses of 2-substituted and 2,6-disubstituted 3-hydroxypiperidine alkaloids, (+)-isofebrifugine and (-)-sedacryptine, from a common, functionalized nonracemic bicyclic building block are achieved, demonstrating the flexibilty of the approach.
Wee
Andrew G H
AG
Department of Chemistry and Biochemistry, University of Regina, Regina, Saskatchewan, Canada S4S 0A2. andrew.wee@uregina.ca
Fan
Gao-Jun
GJ
D000470:Alkaloids / Q000138:chemical synthesis*; D010880:Piperidines / Q000138:chemical synthesis*; D010881:Piperidones; D011799:Quinazolines / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000470:Alkaloids; D010880:Piperidines; D010881:Piperidones; D011799:Quinazolines; C532856:sedacryptine; C001207:febrifugine