Drug-induced spatial dispersion of repolarization.
Spatial dispersion of repolarization in the form of transmural, trans-septal and apico-basal dispersion of repolarization creates voltage gradients that inscribe the J wave and T wave of the ECG. Amplification of this spatial dispersion of repolarization (SDR) underlies the development of life-threatening ventricular arrhythmias associated with inherited or acquired ion channelopathies giving rise to the long QT, short QT and Brugada syndromes (BrS). This review focuses on the role of spatial dispersion of repolarization in drug-induced arrhythmogenesis associated with the long QT and BrS. In the long QT syndrome, drug-induced amplification of SDR is often secondary to preferential prolongation of the action potential duration (APD) of M cells, whereas in the BrS, it is thought to be due to selective abbreviation of the APD of right ventricular epicardium. Among the challenges ahead is the identification of a means to quantitate SDR non-invasively. This review also discusses the value of the interval between the peak and end of the T wave (T(peak)-T(end), T(p)-T(e)) as an index of SDR and transmural dispersion of repolarization, in particular.
Antzelevitch
Charles
C
Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501-1787, USA. ca@mmrl.edu
D000200:Action Potentials / Q000187:drug effects*; D053840:Brugada Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D053447:Channelopathies; D004562:Electrocardiography; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology*; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D016171:Torsades de Pointes / Q000503:physiopathology*