[Succinic acid infusions for correction of renal ischemia in patients with acute purulent pyelonephritis].
The activity of lactate dehydrogenase (LDG), malate dehydrogenase (MDG), concentrations of lactic acid and lipid peroxidation (LPO) products in the blood serum and urine were estimated in 119 patients with acute pyelonephritis (70 cases of serous and 49 cases of purulent). The results of the study showed that acute pyelonephritis patients have activated anaerobic glycolysis. Ischemia leads to accumulation of lactic acid, activation of LPO. Significant differences between the groups of patients reflect strong influence of renaltissue ischemia on activity of systemic metabolic processes and metabolism in renal parenchyma. Standard infusion therapy was given to 30 patients with acute purulent pyelonephritis. 19 patients received solution of succinic acid reamberin. On day 4 of reamberin therapy plasma and urine activity of LDG and MDG attenuated, lactic acid concentration decreased, content of dienic conjugates was close to normal. Patients on reamberin treatment exhibited earlier relief of endogenic intoxication and improvement of blood count. Thus, succinic acid drugs reduce renal ischemia, improve a course of postoperative period in patients with acute purulent pyelonephritis.
Zolotykh
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D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D017148:Infusions, Intraosseous; D007511:Ischemia / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000652:urine; D007668:Kidney / Q000098:blood supply; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000652:urine; D019344:Lactic Acid / Q000097:blood / Q000652:urine; D015227:Lipid Peroxidation / Q000187:drug effects; D008291:Malate Dehydrogenase / Q000097:blood / Q000652:urine; D008297:Male; D008875:Middle Aged; D011704:Pyelonephritis / Q000097:blood / Q000150:complications / Q000601:surgery / Q000652:urine; D012189:Retrospective Studies; D019802:Succinic Acid / Q000008:administration & dosage*; D013997:Time Factors
D019344:Lactic Acid; D019802:Succinic Acid; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase