title: Factors associated with fatigue, sleep, and cognitive function among patients with head and neck cancer.
abstract: BACKGROUND
  Fatigue, sleep disturbances, and cognitive impairment are prevalent and clinically important problems among head and neck cancer patients. Our study aim was to determine the most important correlates of these problems among patients with head and neck cancer.
  
  
  METHODS
  A cross-sectional, self-administered survey was completed by 58 (response rate 79%) patients with head and neck cancer in an academic oncology clinic.
  
  
  RESULTS
  Multiple linear-regression analyses demonstrated that fatigue was associated with younger age (beta=-0.22), previous radiation therapy (beta=0.23), fewer months since cancer diagnosis (beta=-0.25), and depression (beta=0.40). Sleep dysfunction was associated with younger age (beta=-0.31) and higher symptom index (beta=0.39). Cognitive dysfunction was associated with higher symptom index only (beta=-0.49).
  
  
  CONCLUSIONS
  Younger age, previous radiation, more recent cancer diagnosis, depression, and more severe symptoms may be associated with fatigue, sleep, and/or cognitive dysfunction. These results suggest at-risk subgroups warranting more aggressive screening and potentially supportive care interventions.
authors.affiliation: Department of Medicine, SIU School of Medicine, Springfield, Illinois, USA. lrogers@siumed.edu
authors.forename: Laura Q
authors.initials: LQ
authors.lastname: Rogers
authors.forename: Kerry S
authors.initials: KS
authors.lastname: Courneya
authors.forename: K Thomas
authors.initials: KT
authors.lastname: Robbins
authors.forename: Krishna
authors.initials: K
authors.lastname: Rao
authors.forename: James
authors.initials: J
authors.lastname: Malone
authors.forename: Alison
authors.initials: A
authors.lastname: Seiz
authors.forename: Sheryl
authors.initials: S
authors.lastname: Reminger
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Markwell
authors.forename: Vishal
authors.initials: V
authors.lastname: Burra
mesh_terms: D000367:Age Factors; D000368:Aged; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology* / Q000523:psychology; D003430:Cross-Sectional Studies; D005221:Fatigue / Q000453:epidemiology / Q000209:etiology* / Q000523:psychology; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000523:psychology; D006801:Humans; D007087:Illinois / Q000453:epidemiology; D008019:Life Style; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection / Q000523:psychology; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D018714:Radiotherapy, Adjuvant / Q000523:psychology; D012307:Risk Factors; D018434:Sickness Impact Profile; D012893:Sleep Wake Disorders / Q000453:epidemiology / Q000209:etiology* / Q000523:psychology; D011795:Surveys and Questionnaires; D013997:Time Factors