title: Reversal of head drop after discontinuation of olanzapine in a DLB patient.
abstract: We present a 72-year-oldpatient with probable diffuse Lewy body disease and visual hallucinations, who developed subacute reversible "dropped head syndrome" and parkinsonian signs after the introduction of olanzapine at a total daily dose of 10 mg. One week after olanzapine was withdrawn, the patient's posture started to improve. Further improvement was achieved after dopaminergic substitution. Clinical and electrophysiological observations might indicate neck extensor myopathy due to axial rigidity or focal neck dystonia, induced by dopamine receptor blockade.
authors.affiliation: Department of Neurology and Memory Clinic, ZNA-Middelheim and ZNA-Hoge Beuken, Antwerp, Belgium.
authors.forename: Marcel J H
authors.initials: MJ
authors.lastname: Aries
authors.forename: Hans
authors.initials: H
authors.lastname: Debruyne
authors.forename: Sebastiaan
authors.initials: S
authors.lastname: Engelborghs
authors.forename: Nathalie
authors.initials: N
authors.lastname: Le Bastard
authors.forename: Nore
authors.initials: N
authors.lastname: Somers
authors.forename: Dagmar
authors.initials: D
authors.lastname: Gorissen
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Pickut
authors.forename: Peter Paul
authors.initials: PP
authors.lastname: De Deyn
mesh_terms: D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D018492:Dopamine Antagonists / Q000627:therapeutic use; D005260:Female; D006212:Hallucinations / Q000150:complications / Q000188:drug therapy; D019416:Head Movements / Q000187:drug effects*; D006801:Humans; D007738:Kyphosis / Q000188:drug therapy / Q000209:etiology*; D020961:Lewy Body Disease / Q000150:complications / Q000188:drug therapy*; D009135:Muscular Diseases / Q000188:drug therapy / Q000209:etiology; D000077152:Olanzapine
chemical_list: D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D001569:Benzodiazepines; D000077152:Olanzapine