title: Severe ROP in twins after blockage of the renin-angiotensin system during gestation.
abstract: Blockage of the renin-angiotensin system (RAS) during pregnancy is known to cause serious dysfunction of many organs of the foetus and newborn. Angiotensin II is an angiogenic factor and angiotensin-converting enzyme (ACE) inhibitors prevent retinal neovascularisation and their use in preventing proliferative retinopathy of prematurity has been suggested. We report on twin girls born after 32 gestational weeks, who were exposed to blockage of the RAS during gestation, had severely reduced retinal vasculature and developed severe retinopathy of prematurity (ROP) despite receiving very little extra oxygen.
  
  
  CONCLUSIONS
  It is likely that ACE inhibitors and angiotensin receptor blockers not only reduce pathological neovascularisation but also normal vascularisation of the eyes and other organs.
authors.affiliation: Department of Pediatric Ophthalmology, Institute of Neuroscience and Physiology, The Queen Silvia Children's Hospital, Göteborg, Sweden. annalena.hard@oft.gu.se
authors.forename: Anna-Lena
authors.initials: AL
authors.lastname: Hård
authors.forename: Ulla-Britt
authors.initials: UB
authors.lastname: Wennerholm
authors.forename: Aimon
authors.initials: A
authors.lastname: Niklasson
authors.forename: Ann
authors.initials: A
authors.lastname: Hellström
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D005315:Fetal Diseases / Q000139:chemically induced*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications; D011297:Prenatal Exposure Delayed Effects; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012178:Retinopathy of Prematurity / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D012720:Severity of Illness Index; D014427:Twins
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors