title: A straightforward synthesis of tetrameric estrone-based macrocycles.
abstract: A straightforward approach to macrocycles having four estrone-derived nuclei by the sequential Cu-catalyzed Huisgen azide-alkyne cycloaddition-Glaser-Eglington Cu homocoupling has been developed. Due to its efficiency and simplicity, this sequence is useful for application to different natural product scaffolds.
authors.affiliation: Instituto de Química Orgánica, Consejo Superior de Investigaciones Científicas (CSIC), Juan de la Cierva 3, 28006-Madrid, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Ramírez-López
authors.forename: María C
authors.initials: MC
authors.lastname: de la Torre
authors.forename: Hector E
authors.initials: HE
authors.lastname: Montenegro
authors.forename: María
authors.initials: M
authors.lastname: Asenjo
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Sierra
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D004970:Estrone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D001386:Azides; D047028:Macrocyclic Compounds; D004970:Estrone; D003300:Copper