[Clinical features and prognosis of decompensated hepatitis C virus related cirrhosis].
OBJECTIVE
To study the clinical features and prognosis of hepatitis C virus (HCV)-related cirrhosis after the first occurrence of complications.


METHODS
The clinical data of 89 decompensated HCV-related cirrhosis patients were analyzed. Univariate and multivariate analyses of the factors influencing the clinical decompensation were conducted.


RESULTS
Ascites was the most frequent first decompensation (44.9%), followed by upper gastrointestinal bleeding (23.6%), and self-originated peritonitis (20.2%), and hepatic encephalopathy (11.2%). During the follow-up of 62 months (60-66 months) ascites was the most frequent first decompensation (47. 2%), followed by self-originated peritonitis (18.0%), upper gastrointestinal bleeding (15.7%), and hepatic encephalopathy (7.9%). The 5-year survival rates after of the patients with hepatic encephalopathy, ascites, upper gastrointestinal bleeding and self-originated peritonitis as the first decompensated complications were 64.5%, 85.0%, 75.0%, and 83.3% respectively. Multivariate regression analysis showed that esophageal and gastro varices and bilirubin were independently correlated with survival.


CONCLUSIONS
Hepatitis C is a slowly progressing disease. Decompensation occurring in hepatitis C is significantly correlated with survival.
Wu
Chi-Hong
CH
Department of Infectious Diseases, Peking University First Hospital, Beijing, China.
Tian
Geng-Shan
GS
Wang
Qin-Huan
QH
Yu
Yan-Yan
YY
Dou
Yong-Qing
YQ
Xu
Xiao-Yuan
XY
D000328:Adult; D000368:Aged; D001201:Ascites / Q000209:etiology / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D016174:Hepacivirus / Q000235:genetics / Q000502:physiology*; D006526:Hepatitis C / Q000150:complications / Q000473:pathology* / Q000821:virology; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D016019:Survival Analysis
D012367:RNA, Viral