title: Monitoring of neuroactive factors released from a pattern-generating network.
abstract: To detect neuroactive factors in biological fluids, we have previously elaborated a moveable biosensor, the preparation of isolated neuron penetrated with recording microelectrode. Here, we report that, in the pond snail, signals emanated from a central pattern generator (CPG) for feeding and detected by such biosensor correspond to long-term changes in motor output of the CPG as recorded from buccal nerves. The results suggest that combined recording from motor nerves, neurons in situ and the neuron-based biosensors may be a useful tool in studies of the mechanisms underlying network organisation.
authors.affiliation: Laboratory of Comparative Physiology, Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia. compar@pochtamt.ru
authors.forename: I A
authors.initials: IA
authors.lastname: Chistopolsky
authors.forename: D D
authors.initials: DD
authors.lastname: Vorontsov
authors.forename: D A
authors.initials: DA
authors.lastname: Sakharov
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D004594:Electrophysiology; D005247:Feeding Behavior / Q000502:physiology; D008195:Lymnaea / Q000166:cytology / Q000502:physiology*; D008839:Microelectrodes; D009046:Motor Neurons / Q000502:physiology; D009415:Nerve Net / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology
chemical_list: D018377:Neurotransmitter Agents