Magnetic resonance imaging of neural circuits.
A major goal of modern MRI research is to be able to image neural circuits in the central nervous system. Critical to this mission is the ability to describe a number of important parameters associated with neural circuits. These parameters include neural architecture, functional activation of neural circuits, anatomical and functional connectivity of neural circuits, and factors that might alter neural circuits, such as trafficking of immune cells and brain precursor cells in the brain. Remarkably, a variety of work in human and animal brains has demonstrated that all these features of neural circuits can be visualized with MRI. In this Article we provide a brief summary of the new directions in neural imaging research, which should prove useful in future analyses of normal and pathological human brains and in studies of animal models of neurological and psychiatric disorders. At present, few MRI data characterizing the neural circuits in the heart are available, but in this Article we discuss the applicable present developments and the prospects for the future.
Duyn
Jeff
J
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA. jhd@helix.nih.gov
Koretsky
Alan P
AP
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism* / Q000502:physiology*; D002493:Central Nervous System Diseases / Q000175:diagnosis*; D002712:Chlorides; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D017895:Manganese Compounds; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D051381:Rats; D012680:Sensitivity and Specificity
D002712:Chlorides; D017895:Manganese Compounds; C025340:manganese chloride