New labdane diterpenes from Leonurus cardiaca.
Leonurus cardiaca L. has been used in oriental medicine against several types of disorders. The ethanolic extract of leaves of Leonurus cardiaca yielded three new labdane-type diterpenes: 15- O-ethylleopersin C (1), 15- O-methylleopersin C (2), and 15- EPI- O-methylleopersin C (3). Their structures were determined using 1 D and 2 D NMR including 1H-1H COSY, HMQC, HMBC, and ROESY spectroscopic techniques. Compounds (1 - 3) were evaluated for in vitro antiplasmodial activity (D6 and W2 clones) and cytotoxicity (Vero cells).
Agnihotri
Vijai K
VK
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi, USA.
Elsohly
Hala N
HN
Smillie
Troy J
TJ
Khan
Ikhlas A
IA
Walker
Larry A
LA
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031332:Leonurus / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D014709:Vero Cells
D004224:Diterpenes