[The role of P2X7 receptors in modulation of the functional activity of peritoneal macrophages in mice with peritonitis].
The role of P2X7 receptors in modulation of the functional activity of macrophages in mice with model peritonitis has been studied. It is established that the functional activity of murine macrophages under such conditions is increased, which is accompanied by the growth of P2X7(+) macrophages and a bidirectional change of the their functional activity under the action of P2X7 modulators. The role of P2X7-associated mechanisms in regulation of the macrophage activity during inflammation is discussed.
Malinovskaia
N A
NA
Salmina
A B
AB
Karacheva
A A
AA
Salmin
V V
VV
Uspenskaia
Iu A
IuA
Lopatina
O L
OL
Sokolovich
A G
AG
Stepanenko
A V
AV
Per'ianova
O V
OV
Zykova
L D
LD
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D008262:Macrophage Activation; D017737:Macrophages, Peritoneal / Q000276:immunology / Q000502:physiology*; D008297:Male; D051379:Mice; D010538:Peritonitis / Q000276:immunology* / Q000382:microbiology; D018048:Receptors, Purinergic P2 / Q000502:physiology*; D058486:Receptors, Purinergic P2X7; D013203:Staphylococcal Infections / Q000276:immunology / Q000378:metabolism
C546469:P2rx7 protein, mouse; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7; D000255:Adenosine Triphosphate