title: Campylobacter colonization of the chicken induces a proinflammatory response in mucosal tissues.
abstract: Campylobacter jejuni is a major cause of human inflammatory enteritis, but colonizes the gastrointestinal tract of poultry to a high level in a commensal manner. In vitro, C. jejuni induces the production of cytokines from both human and avian-model epithelial cell and macrophage infections. This suggests that, in vivo, Campylobacter could induce proinflammatory signals in both hosts. We investigated whether a proinflammatory cytokine response can be measured in both day-of-hatch and 2-week-old Light Sussex chickens during infection with C. jejuni. A significant induction of proinflammatory chemokine transcript was observed in birds of both ages, compared with levels in mock-infected controls. This correlated with an influx of heterophils but was not associated with any pathology. These results suggest that in poultry there may be a controlled inflammatory process during colonization.
authors.affiliation: Institute for Animal Health, Compton, Berkshire, UK.
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Smith
authors.forename: Manal
authors.initials: M
authors.lastname: Abuoun
authors.forename: Shaun A
authors.initials: SA
authors.lastname: Cawthraw
authors.forename: Tom J
authors.initials: TJ
authors.lastname: Humphrey
authors.forename: Lisa
authors.initials: L
authors.lastname: Rothwell
authors.forename: Pete
authors.initials: P
authors.lastname: Kaiser
authors.forename: Paul A
authors.initials: PA
authors.lastname: Barrow
authors.forename: Michael A
authors.initials: MA
authors.lastname: Jones
mesh_terms: D000818:Animals; D002169:Campylobacter Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary; D016123:Campylobacter jejuni / Q000254:growth & development* / Q000276:immunology / Q000302:isolation & purification; D002432:Cecum / Q000276:immunology / Q000382:microbiology*; D002645:Chickens; D015169:Colony Count, Microbial; D016207:Cytokines / Q000378:metabolism; D007082:Ileum / Q000276:immunology* / Q000382:microbiology; D007413:Intestinal Mucosa / Q000276:immunology* / Q000382:microbiology; D011201:Poultry Diseases / Q000276:immunology / Q000382:microbiology; D013047:Specific Pathogen-Free Organisms
chemical_list: D016207:Cytokines