title: An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss.
abstract: Multiple sclerosis (MS) represents a considerable challenge to experimentally model due to its twin pathologies of inflammatory demyelination and neurodegeneration along with its multifocal and multiphasic nature. Experimental autoimmune encephalomyelitis (EAE) in Biozzi ABH mice has previously been shown to reproduce many clinical features also found in secondary progressive MS. In this study we sought to characterise the pathology of chronic EAE in ABH mice. In addition to marked gliosis, we report substantial demyelination, remyelination and axonal and neuronal loss. Together with the clinical pattern, our findings identify chronic EAE as an excellent model of secondary progressive multiple sclerosis.
authors.affiliation: Cambridge Centre for Brain Repair, University of Cambridge, ED Adrian Building, Forvie Site, Robinson Way, Cambridge, CB2 2PY. UK. dwh27@cam.ac.uk
authors.forename: David W
authors.initials: DW
authors.lastname: Hampton
authors.forename: Jane
authors.initials: J
authors.lastname: Anderson
authors.forename: Gareth
authors.initials: G
authors.lastname: Pryce
authors.forename: Karen-Amanda
authors.initials: KA
authors.lastname: Irvine
authors.forename: Gavin
authors.initials: G
authors.lastname: Giovannoni
authors.forename: James W
authors.initials: JW
authors.lastname: Fawcett
authors.forename: Alastair
authors.initials: A
authors.lastname: Compston
authors.forename: Robin J M
authors.initials: RJ
authors.lastname: Franklin
authors.forename: David
authors.initials: D
authors.lastname: Baker
authors.forename: Siddharthan
authors.initials: S
authors.lastname: Chandran
mesh_terms: D000818:Animals; D000941:Antigens / Q000378:metabolism; D001369:Axons / Q000473:pathology*; D004195:Disease Models, Animal; D005911:Gliosis / Q000209:etiology*; D051379:Mice; D038602:Mice, Biozzi; D020528:Multiple Sclerosis, Chronic Progressive / Q000473:pathology* / Q000503:physiopathology*; D009186:Myelin Sheath / Q000378:metabolism / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D011509:Proteoglycans / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology; D000099216:Chondroitin Sulfate Proteoglycan 4
chemical_list: D000941:Antigens; D009419:Nerve Tissue Proteins; D011509:Proteoglycans; D000099216:Chondroitin Sulfate Proteoglycan 4