Effects of anisomycin on inhibitory avoidance in male and female CD1 mice.
The antibiotic anisomycin inhibits protein synthesis, which much research has suggested is required for the formation of long-term memory. The present work studied the effects of acute subcutaneous administration of anisomycin on the consolidation of memory in an inhibitory avoidance task in CD1 mice of both sexes. The animals were separated by sex and randomly distributed into three groups: two groups were injected with 150 mg/kg anisomycin, one immediately after the training phase and the other 24 h later, while the control group received saline. The interval between training and test was four days. Anisomycin administrated immediately after training produced statistically significant impairment of memory, which was not observed when the drug was administered 24 h after training. No sex differences were observed in the effects of anisomycin. These results extend to female mice the memory impairing effects of anisomycin previously observed in males and endorse the hypothesis that the establishment of long-term memory depends on protein synthesis shortly after training.
Monleón Verdú
Santiago
S
Facultad de Psicología-Departamento de Facultad de Psicobiología, Universitat de València, Valencia, Spain. santiago.monleon@uv.es
Arenas Fenollar
M Carmen
MC
Vinader Caerols
Concepción
C
Ferrer Añó
Aránzazu
A
Parra Guerrero
Andrés
A
D000818:Animals; D000841:Anisomycin / Q000008:administration & dosage / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects*; D005260:Female; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D009433:Neural Inhibition / Q000187:drug effects*; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*
D011500:Protein Synthesis Inhibitors; D000841:Anisomycin