[MR breast screening in patients with genetic mutation].
OBJECTIVE
To compare screening breast MRI with conventional screening techniques in high-risk patients with genetic mutation.


METHODS
Prospective study of 85 patients (mean age of 43 years) with genetic mutation and screening > or = 2 years (mean of 2.7 years, 231 screening examinations). BI-RADS lesions 3-5 were biopsied; isolated BI-RADS 3 lesions on MRI were followed. Results from both techniques were compared. The number of short interval follow-up examinations and biopsy results were reviewed.


RESULTS
Eight cancers were diagnosed (3 in situ, 5 invasive carcinomas including an interval cancer, mean size of 14 mm). The sensitivity values for mammography, US and MRI were 12.5%, 50% and 95%, and specificity values were 98.7%, 97.3% and 94.8% respectively. Nineteen short interval follow-up MRI examinations were performed (19%): 14% of patients at initial screening and 5% and 6% at the the second and third screenings. Thirty-two biopsies were performed in 17 patients, including 18 after MRI (PPV of cytology: 30%, and biopsy: 58%).


CONCLUSIONS
Our results confirm the value of MRI for screening of high-risk patients with genetic mutation.
Daguet
E
E
Service de Radiologie, Institut Curie, Paris Cedex 05, France.
Malhaire
C
C
Hardit
C
C
Athanasiou
A
A
El Khoury
C
C
Thibault
F
F
Ollivier
L
L
Tardivon
A
A
D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography; D008403:Mass Screening; D008875:Middle Aged; D009154:Mutation; D011446:Prospective Studies; D012307:Risk Factors; D014463:Ultrasonography