Adrenergic and serotoninergic regulation of myocardial contractility in patients with various morphofunctional changes in the heart resulting from chronic heart failure.
A relationship between morphofunctional changes in the heart and predominance of adrenergic or serotoninergic influences on the strength of myocardial contraction in the right atrium was revealed in patients with chronic heart failure. During left ventricular hypertrophy, the strength of myocardial contraction in response to serotonin exceeded that induced by epinephrine and was realized via 5-HT2 receptors.
Kirillova
V V
VV
Department of Normal Physiology, Department of Surgical Diseases No. 2, Kazan State Medical University.
Dzhordzhikiya
R K
RK
Nigmatullina
R R
RR
D000322:Adrenergic Agonists / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D006333:Heart Failure / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D010879:Piperazines / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D058830:Serotonin 5-HT2 Receptor Antagonists; D018490:Serotonin Agents / Q000494:pharmacology*
D000322:Adrenergic Agonists; D010879:Piperazines; D058830:Serotonin 5-HT2 Receptor Antagonists; D018490:Serotonin Agents; D012701:Serotonin; C015068:1-(3-chlorophenyl)piperazine; D004837:Epinephrine