title: A newly designed and constructed 20 kHz magnetic field exposure facility for in vivo study.
abstract: Exposure to man-made electromagnetic fields has increased over the past century. As a result of exposure to these fields, concerns have been raised regarding the relationship between electromagnetic fields and human health. Interest in the biological and health effects of intermediate frequency (IF) magnetic fields has grown recently because of the increase in public concern. In order to investigate whether IF magnetic fields have biological effects, we have developed a 20 kHz (IF) magnetic field exposure system for in vivo studies. The exposure facility was designed to study the biological effects of IF magnetic field on laboratory animals. The facility consists of a 9 m x 9 m x 5 m high room containing seven separate rooms including a 5.3 m x 4.5 m x 3 m high specific-pathogen free exposure room. The dimensions of the exposure system are 1.6 m x 1.6 m x 1.616 m high located inside this exposure room. The system is designed to provide magnetic fields up to 200 microT at 20 kHz with the uniformity within +/-5% over the space occupied by animals. After constructing the facility, performance tests were carried out. As a result, it was confirmed that our facility met requirements for evaluation of the biological effects of IF magnetic field on small animal experiments. In this paper, the design, construction, and results of evaluation of an animal exposure facility for the in vivo biological effects of an IF magnetic field are described.
authors.affiliation: Environmental Science Research Laboratory, Central Research Institute of Electric Power Industry, Abiko, Abiko-shi, Chiba, Japan. t-shige@criepi.denken.or.jp
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Shigemitsu
authors.forename: Tadashi
authors.initials: T
authors.lastname: Negishi
authors.forename: Keita
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kawahara
authors.forename: Akira
authors.initials: A
authors.lastname: Haga
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Muramatsu
mesh_terms: D000818:Animals; D001681:Biological Assay / Q000295:instrumentation* / Q000662:veterinary*; D004574:Electromagnetic Fields; D004781:Environmental Exposure; D004867:Equipment Design; D019544:Equipment Failure Analysis; D014916:Whole-Body Irradiation / Q000295:instrumentation* / Q000662:veterinary*