title: [Purulent corneal melting secondary to multidrug-resistant Fusarium oxysporum aggravated by topical corticosteroid therapy].
abstract: Keratomycosis is a rare sight-threatening infection of the cornea. Predisposing factors in its pathogenesis are corneal trauma, mostly of plant origin, contact lenses, and overuse of topical corticosteroids. We report a case of a 44-year-old woman, with no ophthalmologic history, who developed severe keratitis 7 days after beginning topical therapy with a corticosteroid and antibiotic. Microbiological analysis revealed Fusarium oxysporum keratitis. Despite aggressive antifungal therapy with Voriconazole and Amphotericin B, she required a penetrating keratoplasty for impending corneal perforation. A second keratoplasty was performed because of corneal-transplant rejection after 6 months. There was no recurrence of Fusarium infection.
authors.affiliation: Service d'Ophtalmologie, Centre Hospitalier Universitaire de Strasbourg, Strasbourg, France. arno.sauer@orange.fr
authors.forename: A
authors.initials: A
authors.lastname: Sauer
authors.forename: F
authors.initials: F
authors.lastname: Abry
authors.forename: B
authors.initials: B
authors.lastname: Lhermitte
authors.forename: E
authors.initials: E
authors.lastname: Candolfi
authors.forename: C
authors.initials: C
authors.lastname: Speeg-Schatz
authors.forename: T
authors.initials: T
authors.lastname: Bourcier
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000935:Antifungal Agents / Q000627:therapeutic use*; D003316:Corneal Diseases / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery*; D005260:Female; D005670:Fusarium / Q000187:drug effects*; D006801:Humans; D015948:Keratoplasty, Penetrating; D009181:Mycoses / Q000188:drug therapy / Q000601:surgery*; D012086:Reoperation; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents