title: Hormonal status modifies renin-angiotensin system-regulating aminopeptidases and vasopressin-degrading activity in the hypothalamus-pituitary-adrenal axis of female mice.
abstract: The hypothalamus-pituitary-adrenal axis (HPA) participates in the maintenance of cardiovascular functions and in the control of blood pressure. By other hand, it is known that blood pressure regulation and HPA activity are affected by sex hormones. The aim of the present work is to analyze the influence of estradiol and progesterone on renin-angiotensin system (RAS)-regulating aminopeptidase A, aminopeptidase B and aminopeptidase N activities and vasopressin-degrading activity in the HPA axis of ovariectomized mice and ovariectomized mice treated subscutaneously with different doses of estradiol and progesterone. Our data suggest that in female mice, estradiol and progesterone influence RAS-regulating and vasopressin-degrading activities at different levels of the HPA axis.
authors.affiliation: Department of Health Sciences, Physiology, Faculty of Experimental and Health Sciences, University of Jaén, Campus Universitario Las Lagunillas, Jaén, Spain.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: García
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Martínez-Martos
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Mayas
authors.forename: María Pilar
authors.initials: MP
authors.lastname: Carrera
authors.forename: Susana
authors.initials: S
authors.lastname: De la Chica
authors.forename: Pedro
authors.initials: P
authors.lastname: Cortés
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Ramírez-Expósito
mesh_terms: D000626:Aminopeptidases / Q000378:metabolism*; D000818:Animals; D005260:Female; D007031:Hypothalamus / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D012084:Renin-Angiotensin System; D012995:Solubility; D013379:Substrate Specificity; D014667:Vasopressins / Q000378:metabolism*
chemical_list: D014667:Vasopressins; D000626:Aminopeptidases