Age-related muscle dysfunction.
Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to highlight cellular, molecular, and biochemical changes that contribute to age-related muscle dysfunction.
Thompson
LaDora V
LV
Department of Physical Medicine and Rehabilitation, University of Minnesota, MMC 388, 420 Delaware Street, S.E., Minneapolis, MN 55455, USA. thomp067@umn.edu
D000368:Aged; D000375:Aging / Q000502:physiology*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000378:metabolism*; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000503:physiopathology*; D009133:Muscular Atrophy / Q000378:metabolism / Q000503:physiopathology*; D018384:Oxidative Stress; D011499:Protein Processing, Post-Translational
D009124:Muscle Proteins