title: [Effect of local administration of platelet-rich plasma and guided tissue regeneration on the level of bone resorption in early dental implant insertion].
abstract: OBJECTIVE
  Osseointegration is a result of cellular migration, differentiation, bone formation, and bone remodeling on the surface of an implant. Each of these processes depends on platelets and blood coagulum. Platelet-rich plasma (PRP) is used to improve osseointegration and stability of implants. The aim of the research was to test the influence that PRP and guided tissue regeneration in bone defects have on bone defect filling and the level of bone resorption in early implant insertion.
  
  
  METHODS
  This experimental study included 10 dogs. A total of 40 BCT implants were inserted, 4 in each dog (two on the left side and two on the right side), with guided tissue regeneration. Radiologic analyses were done immediately after the insertion and 10 weeks after the insertion. Bone defect filling was measured by a graduated probe 10 weeks after the implant insertion. The following protocols were tested: I - PRP in combination with bovine deproteinized bone (BDB) and resorptive membrane of bovine origin (RBDM), II - BDB + RBDM, III - PRP + RBDM and IV - RBDM.
  
  
  RESULTS
  The applied protocols affected differently the bone defect filling and the level of bone resorption. Significantly better results (the lowest bone resorption) were achieved with protocol I (PRP + BDB + RBDM) in comparison with protocols III (PRP + RBDM) and IV (RBDM), but not with protocol II (BDB + RBDM). On the other hand, no significant difference was found among protocols II (BDB + RBDM), III (PRP + RBDM) and IV (RBDM) in the level of bone tissue resorption.
  
  
  CONCLUSIONS
  The bone defect filling was largest and the level of bone resorption was lowest in the protocol with PRP applied in combination with BDB and RBDM.
authors.affiliation: Vojnomedicinska akademija, Klinika za maksilofacijalnu, oralnu hirurgiju i implantologiju, Beograd.
authors.forename: Milos
authors.initials: M
authors.lastname: Duka
authors.forename: Zoran
authors.initials: Z
authors.lastname: Lazić
authors.forename: Marija
authors.initials: M
authors.lastname: Bubalo
mesh_terms: D000818:Animals; D001862:Bone Resorption; D003758:Dental Implantation, Endosseous; D004285:Dogs; D048091:Guided Tissue Regeneration; D016348:Osseointegration; D053657:Platelet-Rich Plasma