[Comparative research on pharmacodynamics of Danshen co-microemulsion on hemorheology in rats with hyperlipidemia].
OBJECTIVE
To investigate the synergistic effect of salvianolic acids (Sals) and tanshinones (Tans), to compare the pharmacodynamic effect of Danshen co-microemulsion, salvianolic acids microemulsion, tanshinones microemulsion, tanshinones suspension and blank microemulsion on hemorheology in rats with hyperlipidemia.


METHODS
Fat milk was administered to SD rats in the morning for 23 days, and drugs were given in the afternoon since the 13th day. On the 14th day, the blood viscosity, haematocrit and platelet aggregation were determined.


RESULTS
Both Tans and Sals could inhibit the platelet aggregation, and decrease the blood viscosity. The effect of Sals on the decrease of blood viscosity was much more significant than that of other groups. And Tans could significantly inhibit the platelet aggregation than others. Compared to Tans or Sals used separately, co-administration of Tans and Sals at the same time could decrease the blood viscosity and inhibit the platelet aggregation significantly.


CONCLUSIONS
As a new drug carrier, the microemulsion system can increase tanshinone solubility dramatically and improve its bioavailability. And co-mecroemulsion of Tans and Sals can produce the synergy of Tans and Sals preferably and are much more efficient than either Tans microemulsion or Sals microemulsion used alone.
Ji
Hu-Sheng
HS
Department of Pharmacy, 458 Hospital of The PLA, Guangzhou 510602, China.
Yu
Fa
F
Yang
Jun
J
D045784:Abietanes; D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects*; D002109:Caffeic Acids / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D004337:Drug Carriers; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology; D004655:Emulsions; D006949:Hyperlipidemias / Q000139:chemically induced / Q000473:pathology*; D007773:Lactates / Q000494:pharmacology*; D008297:Male; D010616:Phenanthrenes / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood
D045784:Abietanes; D002109:Caffeic Acids; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D004655:Emulsions; D007773:Lactates; D010616:Phenanthrenes; D014280:Triglycerides; C021751:tanshinone; C066201:salvianolic acid A; D002784:Cholesterol