Differential modulation of inflammatory pain by a selective estrogen receptor beta agonist.
To understand the contribution of the estrogen receptor beta, the potent and selective agonist ERb-131 was evaluated in animal models of inflammatory pain. In paradigms of acute and persistent inflammatory pain, ERb-131 did not alleviate the nociception induced by either carrageenan or formalin. However, in the chronic complete Freund's adjuvant model, ERb-131 resolved both inflammatory and hyperalgesic components. Thus, ERb-131 is sufficient to alleviate chronic but not acute inflammatory pain states.
Gardell
Luis R
LR
ACADIA Pharmaceuticals Inc, San Diego, CA, USA.
Hyldtoft
Lene
L
Del Tredici
Andria L
AL
Andersen
Carsten B
CB
Fairbairn
Luke C
LC
Lund
Birgitte W
BW
Gustafsson
Magnus
M
Brann
Mark R
MR
Olsson
Roger
R
Piu
Fabrice
F
D000208:Acute Disease; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D002908:Chronic Disease; D047629:Estrogen Receptor beta / Q000819:agonists*; D005557:Formaldehyde; D005620:Freund's Adjuvant; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D000894:Anti-Inflammatory Agents, Non-Steroidal; D047629:Estrogen Receptor beta; D005557:Formaldehyde; D002351:Carrageenan; D005620:Freund's Adjuvant