title: Different virulence of the species of the Pseudallescheria boydii complex.
abstract: Pseudallescheria boydii sensu lato is a complex of species involved in severe human infections. We have evaluated, using a murine model, the virulence of 2 strains of each of the most representative species of the complex, i.e., P. boydii sensu stricto, P. minutispora, Scedosporium apiospermum, S. aurantiacum and S. dehoogii. We used two different inocula, i.e., 5 x 10(4) conidia/ml (for immunosuppressed animals) and 1 x 10(6) conidia/ml (for immunocompetent animals), which were administered intravenously. Scedosporium aurantiacum and S. dehoogii were the most virulent species, causing the death of 80% and 70% of the immunocompetent mice, respectively. The remaining species only killed 0-20% of the animals.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Fèlix
authors.initials: F
authors.lastname: Gilgado
authors.forename: Josep
authors.initials: J
authors.lastname: Cano
authors.forename: Josepa
authors.initials: J
authors.lastname: Gené
authors.forename: Carolina
authors.initials: C
authors.lastname: Serena
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000818:Animals; D006801:Humans; D008297:Male; D051379:Mice; D009181:Mycoses / Q000382:microbiology*; D011541:Pseudallescheria / Q000302:isolation & purification / Q000472:pathogenicity*; D021681:Scedosporium / Q000302:isolation & purification / Q000472:pathogenicity*; D016019:Survival Analysis; D014774:Virulence