title: [Study of the role of the right and left orbitofrontal cortex in compensatory cerebral reactions after acute brainstem damage].
abstract: Significance of the right and left orbitofrontal cortex (OFC) in recovery after acute brainstem lesion (at the level of n. Deiters) was investigated using rat model of complex brainstem-orbitofrontal cerebral damage. It was found that the right-side lesion of the OFC combined with isolated brainstem damage resulted in aggravation of the animal condition and highly probable lethal outcome within the first two weeks after surgery (because of the brain circulation disorder of hemorrhagic type). It may be associated with sympathetic activation. It is suggested that a certain "stimulation" of the left OFC (as the effect of its incomplete destruction) involves a parasympathetic compensatory reaction that allows animals with a severe brainstem pathology to survive. It is shown that, with the general nonspecific tendency to postoperative increase in emotionality, the greatest shifts in the emotional sphere take place under conditions of a combined damage of the brainstem and left OFC.
authors.forename: M R
authors.initials: MR
authors.lastname: Novikova
authors.forename: E V
authors.initials: EV
authors.lastname: Sharova
authors.forename: M A
authors.initials: MA
authors.lastname: Kulikov
authors.forename: V N
authors.initials: VN
authors.lastname: Mats
authors.forename: L V
authors.initials: LV
authors.lastname: Shishkina
mesh_terms: D000208:Acute Disease; D000818:Animals; D001930:Brain Injuries / Q000503:physiopathology / Q000523:psychology; D001933:Brain Stem / Q000293:injuries / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D004572:Electrolysis; D005625:Frontal Lobe / Q000293:injuries / Q000503:physiopathology*; D007839:Functional Laterality; D008297:Male; D051381:Rats