Effect of Shenqi Compound Formula on PPARgamma in white adipose tissue of rats with macrovascular lesion in early stage of diabetes.
OBJECTIVE
To investigate the effect of Shenqi Compound Formula (SCF) on peroxisome proliferators-activated receptor gamma (PPARgamma) in white adipose tissue of rats with macrovascular lesion in early stage of diabetes.


METHODS
Corresponding treatment was given to rats in model group, Ramipril group, normal control group, low dosage SCF group and high dosage SCF group respectively for 32 days. The expressions of PPARgamma and adiponectin Messenger RNA (mRNA) were detected by real-time reverse transcriptase polymerase chain reaction.


RESULTS
The expressions of PPARgamma and adiponectin mRNA increased significantly in both low and high dosage SCF groups as compared with the model group, and a positive linear correlation was found between the expressions of PPARgamma and adiponectin mRNA.


CONCLUSIONS
SCF can prevent macrovascular lesion in early stage of diabetes, which is possibly related with up-regulating expressions of PPARgamma and activating PPARgamma.
Zhang
Hongmin
H
West China Hospital of Sichuan University, Chengdu 610041, China.
Xie
Chunguang
C
Chen
Shiwei
S
Xie
Yiqiang
Y
D052436:Adipose Tissue, White / Q000378:metabolism*; D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D008297:Male; D047495:PPAR gamma / Q000235:genetics* / Q000378:metabolism; D011897:Random Allocation; D051381:Rats
D004365:Drugs, Chinese Herbal; D047495:PPAR gamma