[Fundamentals of interferon system function in pathology and molecular biological peculiarities of interferon production].
Molecular biological peculiarities of interferon system function in PV-infected persons have been found. It is evident that the interferon production, anti-inflammatory cytokines and their receptors and also defensines play an important role in the mechanism of virus interaction with sensitive cells of macroorganism with development of pathological process. The new conception of expediency for the use of interferons and their inducers as the polyfunctional regulators with a broad spectrum of activity for the treatment of PV-infected patients was suggested. Patents for the method of treatment of PV-infected patients were obtained. New inducers of interferon as well as recombinant IFN-alpha-2b was developed. Our results were introduced in the medical practice.
Spivak
M Ia
MIa
Didenko
L F
LF
Lazarenko
L M
LM
Zholobak
N M
NM
D000047:Academies and Institutes / Q000266:history; D000818:Animals; D000998:Antiviral Agents / Q000266:history / Q000494:pharmacology / Q000627:therapeutic use; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007372:Interferons / Q000096:biosynthesis / Q000266:history / Q000627:therapeutic use; D008829:Microbiology / Q000266:history; D030361:Papillomavirus Infections / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D014455:Ukraine; D014773:Virology / Q000266:history
D000998:Antiviral Agents; D007372:Interferons