Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis.
Ultraviolet radiation (UVR) may contribute to multiple sclerosis (MS) outcome by a mechanism involving vitamin D and the vitamin D receptor (VDR). In 512 patients with MS duration of 10 or more years, we studied the association of VDR single nucleotide polymorphisms (A/G(1229), C/G(3444), G/A(3944), CC(20965), CC(30056), F/f(30875), C/T(48200), T/t(65013)) with outcome or disability. ff(30875) frequency was lower in cases with EDSS > or = 6.0 than with scores < 6.0 (odds ratio = 0.38, 95% CI = 0.20-0.70). The association of ff(30875) with outcome was not mediated by cumulative exposure to UVR as assessed by questionnaire; low exposure (odds ratio = 0.42, 95% CI = 0.14-1.34) and high exposure (odds ratio = 0.34, 95% CI = 0.16-0.73).
Mamutse
G
G
Keele Multiple Sclerosis Research Group, Department of Neurology, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK.
Woolmore
J
J
Pye
E
E
Partridge
J
J
Boggild
M
M
Young
C
C
Fryer
A
A
Hoban
P R
PR
Rukin
N
N
Alldersea
J
J
Strange
R C
RC
Hawkins
C P
CP
D000328:Adult; D004185:Disability Evaluation; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D008297:Male; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors; D014466:Ultraviolet Rays; D055815:Young Adult
D018167:Receptors, Calcitriol