title: Dynamic combinatorial discovery of a [2]-catenane and its guest-induced conversion into a molecular square host.
abstract: A simple water-soluble naphthalenedithiol building block is converted quantitatively into a series of octameric [2]-catenanes, composed of two interlocked molecular squares. When this mixture is re-equilibrated in the presence of an adamantyl ammonium guest, the catenanes disassemble into their macrocyclic components that bind the guest with nanomolar affinity in water.
authors.affiliation: University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
authors.forename: Kevin R
authors.initials: KR
authors.lastname: West
authors.forename: R Fred
authors.initials: RF
authors.lastname: Ludlow
authors.forename: Peter T
authors.initials: PT
authors.lastname: Corbett
authors.forename: Pol
authors.initials: P
authors.lastname: Besenius
authors.forename: Friederike M
authors.initials: FM
authors.lastname: Mansfeld
authors.forename: Peter A G
authors.initials: PA
authors.lastname: Cormack
authors.forename: David C
authors.initials: DC
authors.lastname: Sherrington
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Goodman
authors.forename: Marc C A
authors.initials: MC
authors.lastname: Stuart
authors.forename: Sijbren
authors.initials: S
authors.lastname: Otto
mesh_terms: D043863:Catenanes / Q000138:chemical synthesis* / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008958:Models, Molecular; D015394:Molecular Structure; D010316:Particle Size; D012995:Solubility; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D043863:Catenanes; D013438:Sulfhydryl Compounds; D014867:Water