Effects of combined lower body endurance and upper body resistance training on the satellite cell pool in elderly subjects.
To distinguish the respective potential of endurance and resistance training to increase the satellite cell pool, we investigated the effects of 14 weeks of concurrent lower body endurance and upper body resistance training (3 sessions/week) on vastus lateralis (VLat) and deltoid (Del) muscles of 10 active elderly men. NCAM+ satellite cells and myonuclear number were assessed in VLat and Del. After 14 weeks of training the NCAM+ satellite cell pool increased similarly (+38%) in both muscles, mainly in type II muscle fibers (P < 0.05). There was no significant change in myonuclear number or myonuclear domain in either muscle. Combining resistance training in the upper limbs with endurance training in the lower limbs is an efficient strategy to enhance the satellite cell pool in upper and lower body muscles in elderly subjects. Our results provide a practical reference for the determination of optimal exercise protocols to improve muscle function and regeneration in the elderly.
Verney
Julien
J
Laboratory of Physiology and Physiopathology of Exercise and Handicap, University Jean Monnet, University Hospital, Saint Etienne, France.
Kadi
Fawzi
F
Charifi
Nadia
N
Féasson
Léonard
L
Saafi
Mohamed Ali
MA
Castells
Josiane
J
Piehl-Aulin
Karin
K
Denis
Christian
C
D000368:Aged; D001706:Biopsy / Q000379:methods; D018929:Cell Culture Techniques / Q000379:methods; D016001:Confidence Intervals; D015444:Exercise / Q000502:physiology*; D015577:Geriatric Assessment; D006801:Humans; D035002:Lower Extremity / Q000294:innervation*; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D018485:Muscle Fibers, Skeletal / Q000145:classification / Q000502:physiology; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000166:cytology* / Q000502:physiology; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism; D010806:Physical Education and Training / Q000379:methods; D032496:Satellite Cells, Skeletal Muscle / Q000502:physiology*; D034941:Upper Extremity / Q000294:innervation*
D019006:Neural Cell Adhesion Molecules