title: Membranoproliferative glomerulonephritis in a girl and her mother.
abstract: A girl and her mother were diagnosed as having membranoproliferative glomerulonephritis (MPGN) type I. Microscopic hematuria and proteinuria presented at 9 years of age in the mother and at 14 years in the daughter. Both had persistent hypocomplementemia and were treated with steroids. When the mother was 40 years old, proteinuria was still continuing and creatinine clearance was 64.4 ml/min per 1.73 m(2). When the daughter was 15 years old, microscopic hematuria was still continuing. To our knowledge, familial cases of MPGN in two generations have not been reported in Japan.
authors.affiliation: Department of Pediatrics, Toho University Medical Center, Sakura Hospital, 564-1 Shimoshizu, Sakura, Chiba, Japan. motoyan@basil.ocn.ne.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Motoyama
authors.forename: Ken
authors.initials: K
authors.lastname: Sakai
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohashi
authors.forename: Sonoo
authors.initials: S
authors.lastname: Mizuiri
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hatori
authors.forename: Kikuo
authors.initials: K
authors.lastname: Iitaka
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Koitabashi
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D003165:Complement System Proteins / Q000276:immunology; D003404:Creatinine / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D010375:Pedigree; D011247:Pregnancy; D011507:Proteinuria / Q000209:etiology; D013256:Steroids / Q000627:therapeutic use
chemical_list: D013256:Steroids; D003165:Complement System Proteins; D003404:Creatinine