title: Surgery and topic cidofovir for nasal squamous papillomatosis in HIV+ patient.
abstract: Intranasal schneiderian exophytic squamous papillomatosis is rare and often secondary to human papilloma virus infection. Treatment usually consists of repeated surgical or endoscopic excisions due to recurrences. The use of intravenous or intralesional or topically applied cidofovir, a cytidine nucleotide analogue suppressing viral replication, alone or as adjuvant therapy has been proposed and described in the literature for the treatment of other human papillomavirus (HPV)-related lesions. We firstly describe a successful combined approach of surgery and topical cidofovir for recurrent nasal HPV-related exophytic squamous papillomatosis in a HIV-infected patient. As no untoward effects were encountered this therapeutical option should be considered in the management of recurrent nasal papillomatosis in HIV-infected patients.
authors.affiliation: Department of Otorhinolarynogological and Ophthalmological Sciences, University of Milan, Policlinico Foundation IRCCS, Via F. Sforza 35, 20122, Milan, Italy. pasquale.capaccio@unimi.it
authors.forename: Pasquale
authors.initials: P
authors.lastname: Capaccio
authors.forename: Francesco
authors.initials: F
authors.lastname: Ottaviani
authors.forename: Valeria
authors.initials: V
authors.lastname: Cuccarini
authors.forename: Mario
authors.initials: M
authors.lastname: Corbellino
authors.forename: Carlo
authors.initials: C
authors.lastname: Parravicini
authors.forename: Stefano
authors.initials: S
authors.lastname: Menzo
authors.forename: Antonio
authors.initials: A
authors.lastname: Schindler
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Pignataro
mesh_terms: D000287:Administration, Topical; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000077404:Cidofovir; D003131:Combined Modality Therapy; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004724:Endoscopy; D006679:HIV Seropositivity; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D063065:Organophosphonates / Q000008:administration & dosage*; D010212:Papilloma / Q000188:drug therapy* / Q000601:surgery*
chemical_list: D000970:Antineoplastic Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir