title: Chordoid glioma: a case report and molecular characterization of five cases.
abstract: Chordoid gliomas are rare, slow-growing neoplasms of the anterior third ventricle. We reported a case of chordoid glioma in a 41-year-old man with obstructive hydrocephalus. Histologically, the tumor consisted of polygonal epithelioid cells admixed with elongated cells in a myxoid stroma. A prominent lymphoplasmacytic infiltrate was present. The tumor cells expressed glial fibrillary acidic protein (GFAP), epithelial membrane antigen (EMA), vimentin, CD31, CD34, epidermal growth factor receptor (EGFR) and S100 but were negative for pankeratin and E-cadherin. The percentage of Ki67 positive cells was approximately 3%. Weak p53 immunoreactivity was seen in less than 10% of the cells. Array comparative genomic hybridization performed on this case, as well as on four other archived cases, showed losses at several loci. Fluorescence in situ hybridization (FISH) confirmed consistent genetic alterations at 9p21 and 11q13. These are the fifth through ninth reported cases of chordoid gliomas with molecular characterization suggesting a distinct genetic origin from other gliomas.
authors.affiliation: Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. horbinskicm@upmc.edu
authors.forename: Craig
authors.initials: C
authors.lastname: Horbinski
authors.forename: Sanja
authors.initials: S
authors.lastname: Dacic
authors.forename: Roger E
authors.initials: RE
authors.lastname: McLendon
authors.forename: Kathy
authors.initials: K
authors.lastname: Cieply
authors.forename: Michael
authors.initials: M
authors.lastname: Datto
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Brat
authors.forename: Charleen T
authors.initials: CT
authors.lastname: Chu
mesh_terms: D000328:Adult; D002551:Cerebral Ventricle Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D055028:Comparative Genomic Hybridization; D005260:Female; D005910:Glioma / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D042282:Microdissection; D008875:Middle Aged; D019635:Neurosurgical Procedures; D016133:Polymerase Chain Reaction; D020542:Third Ventricle / Q000473:pathology*; D014057:Tomography, X-Ray Computed