Salt-induced guest relocation from a macrocyclic cavity into a biomolecular pocket: interplay between cucurbit[7]uril and albumin.
The binding affinity of Neutral Red with cucurbit[7]uril (CB7) can be fine-tuned by addition and competitive binding of metal ions, which leads also to a pK(a) shift of the dye; this can be exploited to relocate the dye from the macrocyclic cavity of CB7 to the biomolecular pocket of bovine serum albumin.
Shaikh
Mhejabeen
M
Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Mumbai, 400 085, India.
Mohanty
Jyotirmayee
J
Bhasikuttan
Achikanath C
AC
Uzunova
Vanya D
VD
Nau
Werner M
WM
Pal
Haridas
H
D000818:Animals; D001667:Binding, Competitive; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D002417:Cattle; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000737:chemistry*; D009499:Neutral Red / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry*; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
D001952:Bridged-Ring Compounds; D007093:Imidazoles; D009499:Neutral Red; D012710:Serum Albumin, Bovine; D012965:Sodium Chloride; C456276:cucurbit(7)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils