Neuroleukemiosis: case report of leukemic nerve infiltration in acute lymphoblastic leukemia.
We describe a patient in remission from acute lymphoblastic leukemia who developed a painless common peroneal neuropathy. Magnetic resonance imaging (MRI) revealed nerve thickening and enhancement, while a positron emission tomography (PET) scan demonstrated increased fluorodeoxyglucose uptake in a large segment of the neurovascular bundle, suggesting peripheral nerve infiltration. Both findings resolved following treatment with chemotherapy that crossed the blood-nerve barrier. In selected patients presenting with peripheral neuropathy, MRI and PET scan can be helpful in the diagnosis of peripheral nerve infiltration.
Aregawi
Dawit G
DG
Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.
Sherman
Jonathan H
JH
Douvas
Michael G
MG
Burns
Ted M
TM
Schiff
David
D
D000328:Adult; D004358:Drug Therapy / Q000379:methods; D004558:Electric Stimulation / Q000379:methods; D004576:Electromyography / Q000379:methods; D019788:Fluorodeoxyglucose F18; D006801:Humans; D017254:Leukemic Infiltration / Q000209:etiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D020427:Peroneal Neuropathies / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D049268:Positron-Emission Tomography / Q000379:methods; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects
D019788:Fluorodeoxyglucose F18