title: [Effect of bilateral intercostal nerve protection on post-thoracotomy pain relief: a prospective single-blinded randomized study].
abstract: OBJECTIVE
  To study the efficacy of bilateral intercostal nerve protection on pain relief after thoracotomy.
  
  
  METHODS
  Sixty patients in need of thoracotomy were randomized into 3 groups: Group C (control group, undergoing standard posterolateral thoracotomy, n = 18), Group U (unilateral intercostal nerve protection group, undergoing protection of intercostal nerve above the incision based on the standard posterolateral thoracotomy, n = 20), and Group B (bilateral intercostal nerve protection group, undergoing protection of intercostal nerves above and below the incision based on the standard posterolateral thoracotomy, n = 22). Numeric rating scale (NRS) was adopted to document the severity of pain at different time points after surgery. The amount of analgesic use was recorded as well.
  
  
  RESULTS
  The pain scores recorded on the postoperative days 2 to 7 and 1 month after surgery of Group B were all significantly lower than those of Group C (all P < 0.05). Significant pain relief was observed in Group U within the 7 postoperative days compared with Group C; however, there were not significant differences in pain scores among different groups 1 month after surgery. Pain relief after the removal of chest tubes was found only in Group B (P = 0.020). The incidence of morbidity was similar among the 3 groups.
  
  
  CONCLUSIONS
  Protection of bilateral intercostal nerves around the incision contributes to significant pain relief after operation without increase of the morbidity of complications.
authors.affiliation: Department of Thoracic Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Yan
authors.forename: Nan
authors.initials: N
authors.lastname: Wu
authors.forename: Hong-chao
authors.initials: HC
authors.lastname: Xiong
authors.forename: Qing-feng
authors.initials: QF
authors.lastname: Zheng
authors.forename: Chao
authors.initials: C
authors.lastname: Lü
authors.forename: Yuan
authors.initials: Y
authors.lastname: Feng
authors.forename: Yue
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007367:Intercostal Nerves / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D016037:Single-Blind Method; D019616:Thoracic Surgical Procedures / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome