title: Fluorouracil-induced hepatic artery spasm preventing yttrium-90 microsphere administration.
abstract: Coronary spasm is a recognized complication of fluorouracil (FU) chemotherapy. Spasm has been documented at other arterial sites with FU. SIR-spheres (radioactive yttrium-90 microspheres) are increasingly being used for hepatic colorectal metastasis. Various FU schedules are reported in the literature, and it is likely there will be coadministration with SIR-spheres. There is, however, little specific information in these reports as to the timing of FU and hepatic arterial spasm associated with infusion FU, which is a potential complication that should be considered.
authors.affiliation: Department of Oncology, The Queen Elizabeth Hospital, Woodville Road, Woodville, South Australia.
authors.forename: Amanda
authors.initials: A
authors.lastname: Townsend
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Price
authors.forename: Kevin
authors.initials: K
authors.lastname: Patterson
authors.forename: Ken
authors.initials: K
authors.lastname: Pittman
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects; D002214:Capsules / Q000008:administration & dosage; D003951:Diagnostic Errors / Q000517:prevention & control*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006499:Hepatic Artery / Q000187:drug effects*; D006801:Humans; D008863:Microspheres; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011838:Radiation-Sensitizing Agents / Q000009:adverse effects; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D013035:Spasm / Q000139:chemically induced* / Q000000981:diagnostic imaging; D015021:Yttrium Radioisotopes / Q000008:administration & dosage*
chemical_list: D000964:Antimetabolites, Antineoplastic; D002214:Capsules; D011838:Radiation-Sensitizing Agents; D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes; D005472:Fluorouracil