title: Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery.
abstract: There is a need to develop early biomarkers of acute kidney injury following cardiac surgery, where morbidity and mortality are increased by its presence. Plasma cystatin C (CyC) and plasma and urine Neutrophil Gelatinase Associated Lipocalin (NGAL) have been shown to detect kidney injury earlier than changes in plasma creatinine in critically ill patients. In order to determine the utility of urinary CyC levels as a measure of kidney injury, we prospectively collected plasma and urine from 72 adults undergoing elective cardiac surgery for analysis. Acute kidney injury was defined as a 25% or greater increase in plasma creatinine or renal replacement therapy within the first 72 hours following surgery. Plasma CyC and NGAL were not useful predictors of acute kidney injury within the first 6 hours following surgery. In contrast, both urinary CyC and NGAL were elevated in the 34 patients who later developed acute kidney injury, compared to those with no injury. The urinary NGAL at the time of ICU arrival and the urinary CyC level 6 hours after ICU admission were most useful for predicting acute kidney injury. A composite time point consisting of the maximum urinary CyC achieved in the first 6 hours following surgery outperformed all individual time points. Our study suggests that urinary CyC and NGAL are superior to conventional and novel plasma markers in the early diagnosis of acute kidney injury following adult cardiac surgery.
authors.affiliation: Section of Nephrology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA.
authors.forename: Jay L
authors.initials: JL
authors.lastname: Koyner
authors.forename: Michael R
authors.initials: MR
authors.lastname: Bennett
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Worcester
authors.forename: Qing
authors.initials: Q
authors.lastname: Ma
authors.forename: Jai
authors.initials: J
authors.lastname: Raman
authors.forename: Valluvan
authors.initials: V
authors.lastname: Jeevanandam
authors.forename: Kristen E
authors.initials: KE
authors.lastname: Kasza
authors.forename: Michael F
authors.initials: MF
authors.lastname: O'Connor
authors.forename: David J
authors.initials: DJ
authors.lastname: Konczal
authors.forename: Sharon
authors.initials: S
authors.lastname: Trevino
authors.forename: Prasad
authors.initials: P
authors.lastname: Devarajan
authors.forename: Patrick T
authors.initials: PT
authors.lastname: Murray
mesh_terms: D000209:Acute-Phase Proteins / Q000652:urine; D015415:Biomarkers / Q000652:urine; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D055316:Cystatin C / Q000652:urine*; D017558:Elective Surgical Procedures; D007674:Kidney Diseases / Q000175:diagnosis* / Q000209:etiology; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine; D011446:Prospective Studies; D011518:Proto-Oncogene Proteins / Q000652:urine; D013997:Time Factors
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D055316:Cystatin C; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins