[Research progress on interactions between luteolin (glucosides) and drug-metabolizing enzyme].
The paper summarizes the interactions between luteolin (glucosides) and drug-metabolizing enzyme from the literature of recent years and our research work. The metabolism of luteolin is chiefly mediated by phase II metabolic enzyme. Its glucosides are firstly hydrolyzed into aglycone in intestinal tract, and then absorbed and metabolized. Luteolin has the effect on the induction of CYP3A, and on the inhibition of CYPIA, 1B and 2E. Also, luteolin is an effective inhibitor of CYP2B6, CYP2C9 and CYP2D6. Luteolin can induce and inhibit UGTs and SULTs. It can also inhibit multi ABC transport proteins. Understanding the interactions between luteolin (glucosides) and drug-metabolizing enzyme has an important significance in guiding clinical use of the drug.
Ying
Jing-Yan
JY
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Gu
Shao-Jun
SJ
Yao
Tong-Wei
TW
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D004347:Drug Interactions; D004790:Enzyme Induction; D014453:Glucuronosyltransferase / Q000378:metabolism; D006801:Humans; D047311:Luteolin / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D015238:Sulfotransferases / Q000378:metabolism
D018528:ATP-Binding Cassette Transporters; D001189:Aryl Hydrocarbon Hydroxylases; D014453:Glucuronosyltransferase; D015238:Sulfotransferases; D047311:Luteolin