title: Synthesis of N-substituted derivatives of 8,11-dimethyl-3,5-dioxo-4-azatricyclo[5.2.2.0(2,6)]undec-8-en-1-yl acetate and screening of cytotoxic activity of selected azatricycloundecane compounds.
abstract: This paper reports the synthesis of a number of aminoalkyl derivatives of 8,11-dimethyl-3,5-dioxo-4-azatricyclo[5.2.2.0(2,6)]undec-8-en-1-yl acetate and 1,11 -dimethyl-4-azatricyclo [5.2.2.0(2,6)]undecan-3,5,8-tri-one. Fourteen compounds were prepared and the in vitro cytotoxic activities were evaluated against human cancer cell lines originating from solid tumors in the National Cancer Institute, Bethesda, MD, USA.
authors.affiliation: Department of Medical Chemistry, Medical University, Warszawa, Poland. jerzy.kossakowski@am.edu.pl
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kossakowski
authors.forename: Bozena
authors.initials: B
authors.lastname: Kuran
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D000473:Alkanes; D000970:Antineoplastic Agents; D001372:Aza Compounds; C022884:undecane