[SINEs in mammalian genomes can serve as additional signals in formation of facultative heterochromatin].
Using computer-based methods we determined the global distribution of short interspersed nuclear elements (SINEs) in the human and mouse X chromosomes. It has been shown that this distributions is similar to the distributions of CpG islands and genes but is different from the distribution of LINE1 elements. Since SINEs (human Alu and mouse B2) may have binding sites for Polycomb protein YY1, we suggest that these repeats can serve as additional signals ("boosters") in Polycomb-dependent silencing of gene rich segments during X inactivation.
Usmanova
N M
NM
Kazakov
V I
VI
Tomilin
N V
NV
D020087:Alu Elements / Q000235:genetics; D000818:Animals; D001330:Electronic Data Processing; D005260:Female; D006570:Heterochromatin / Q000378:metabolism; D006801:Humans; D008322:Mammals / Q000235:genetics; D051379:Mice; D020086:Short Interspersed Nucleotide Elements / Q000235:genetics* / Q000502:physiology; D014960:X Chromosome / Q000235:genetics* / Q000378:metabolism; D049951:X Chromosome Inactivation; D050986:YY1 Transcription Factor / Q000378:metabolism
D006570:Heterochromatin; D050986:YY1 Transcription Factor; C494698:YY1 protein, human; C494699:Yy1 protein, mouse