[Inhibitory effect of tea polyphenols and EGCG on cultured hypertrophic myocyte induced by Ang II].
OBJECTIVE
To observe the potential effect of tea polyphenols and EGCG on cultured hypertrophic myocyte induced by Ang II.


METHODS
The study used cultured neonatal rat myocytes as a model to observe the potential effects of 10 microg/ml, 50 microg/ml and 100 microg/ml tea polyphenols and EGCG on hypertrophic myocyte induced by Ang II. We will measure the protein contents, the volume of myocyte, the numbers of fibrocasts.


RESULTS
When compared to control group (untreated), the protein contents, the volume of myocytes, the numbers of fibrocasts in Ang II group increased. But all those in tea polyphenols and EGCG group decreased in a dose-dependent manner, when compared to Ang II group. However, the number of the myocyte cells in all groups has no significantly changed.


CONCLUSIONS
Tea polyphenols and EGCG can effectively inhibit hypertrophy of cultured neonatal rat heart myocytes induced by Ang II.
Cui
Wenming
W
Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Mao
Weifeng
W
Du
Haifang
H
Li
Ning
N
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D006332:Cardiomegaly / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D002392:Catechin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D002478:Cells, Cultured; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D032383:Myocytes, Cardiac / Q000473:pathology*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D059808:Polyphenols; D051381:Rats; D017208:Rats, Wistar; D013662:Tea / Q000737:chemistry*
D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013662:Tea; D000804:Angiotensin II; D002392:Catechin; C045651:epigallocatechin gallate