title: Genomic stability: FANCJ-dependent G4 DNA repair.
abstract: G-rich regions have the potential to form G4 DNA upon replication, which can lead to genomic instability. FANCJ, a G4 DNA helicase, has been shown to be critical for the stability of regions that match the G4 signature motif by experiments analyzing its nematode homolog.
authors.affiliation: Department of Immunology, University of Washington School of Medicine, 1959 NE Pacific St., Seattle, Washington 98195-7650, USA. maizels@u.washington.edu
authors.forename: Nancy
authors.initials: N
authors.lastname: Maizels
mesh_terms: D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000378:metabolism*; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism; D004260:DNA Repair; D018509:DNA, Helminth / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D051856:Fanconi Anemia Complementation Group Proteins / Q000378:metabolism*; D017238:Genes, Helminth; D042822:Genomic Instability; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009690:Nucleic Acid Conformation
chemical_list: C102108:BACH1 protein, human; D050976:Basic-Leucine Zipper Transcription Factors; D029742:Caenorhabditis elegans Proteins; D018509:DNA, Helminth; D051856:Fanconi Anemia Complementation Group Proteins; D004247:DNA; D004265:DNA Helicases; C464789:Dog-1 protein, C elegans