Primary yolk sac tumor of the omentum: a case report and review of the literature.
BACKGROUND
Extraovarian yolk sac tumors (YSTs) arising in the omentum represent an exceedingly rare malignancy.


METHODS
A 37-year-old Korean woman was admitted with a history of lower abdominal pain of 3 weeks duration. Pelvic computerized tomography (CT) scanning reported a bilateral ovarian malignancy with peritoneal seeding. Exploration findings revealed a greater omental mass and the result of frozen biopsy was adenocarcinoma or mesothelioma. She was treated with supracolic omentectomy, bilateral salpingo-oophorectomy, pelvic and paraaortic lymph node dissection, multiple peritoneal biopsies and appendectomy. Histological evaluation of the specimen after operation exhibited typical patterns of YST and stained for alpha-fetoprotein (AFP) and cytokeratin. Four courses of bleomycin, etoposide, and cisplatin (BEP) combination chemotherapy repeated every 3 weeks were added to therapy and she has remained free of disease for 1 year after completion of the therapy.


CONCLUSIONS
To our knowledge this is the fourth case of primary omental YST. A review of the literature indicates that the diagnosis of YST requires proper evaluations of tumor makers and a skilled pathologist for analysis of frozen sections.
Kim
Sang-Wook
SW
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea.
Park
Ju-Hee
JH
Lim
Myung-Chul
MC
Park
Jeong-Yeol
JY
Yoo
Chong-Woo
CW
Park
Sang-Yoon
SY
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001062:Appendectomy; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D018240:Endodermal Sinus Tumor / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D005047:Etoposide / Q000008:administration & dosage; D005187:Fallopian Tubes / Q000601:surgery; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007633:Keratins / Q000032:analysis; D008197:Lymph Node Excision; D009852:Omentum / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D010537:Peritoneum / Q000473:pathology; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins; D001761:Bleomycin; D007633:Keratins; D005047:Etoposide; D002945:Cisplatin