High-resolution Fourier-domain optical coherence tomography and microperimetric findings after macula-off retinal detachment repair.
OBJECTIVE
To evaluate the morphologic changes in the macula of subjects with repaired macula-off retinal detachment (RD) using high-resolution Fourier-domain optical coherence tomography (FD OCT) and to perform functional correlation in a subset of patients using microperimetry (MP-1).


METHODS
Prospective observational case series.


METHODS
Seventeen eyes from 17 subjects who had undergone anatomically successful repair for macula-off, rhegmatogenous RD at least 3 months earlier and without visually significant maculopathy on funduscopy.


METHODS
FD OCT with axial and transverse resolution of 4.5 mum and 10 to 15 mum, respectively, was used to obtain rapid serial B-scans of the macula, which were compared with that from Stratus OCT. The FD OCT B-scans were used to create a 3-dimensional volume, from which en face C-scans were created. Among 11 patients, MP-1 was performed to correlate morphologic changes with visual function.


METHODS
Stratus OCT scans, FD OCT scans, and MP-1 data.


RESULTS
Stratus OCT and FD OCT images of the macula were obtained 3 to 30 months (mean 7 months) postoperatively in all eyes. Although Stratus OCT revealed photoreceptor disruption in 2 eyes (12%), FD OCT showed photoreceptor disruption in 13 eyes (76%). This difference was statistically significant (P<0.001, chi(2)). Both imaging modalities revealed persistent subretinal fluid in 2 eyes (12%) and lamellar hole in 1 eye. Among 7 subjects who had reliable MP-1 data, areas of abnormal function corresponded to areas of photoreceptor layer disruptions or persistent subretinal fluid in 5 subjects (71%); one subject had normal FD OCT and MP-1.


CONCLUSIONS
Photoreceptor disruption after macula-off RD repair is a common abnormality in the macula that is detected better with FD OCT than Stratus OCT. A good correlation between MP-1 abnormality and presence of photoreceptor disruption or subretinal fluid on FD OCT demonstrates that these anatomic abnormalities contribute to decreased visual function after successful repair.
Smith
Allison J
AJ
Department of Ophthalmology and Vision Science, University of California Davis Medical Center, Sacramento, California, USA.
Telander
David G
DG
Zawadzki
Robert J
RJ
Choi
Stacey S
SS
Morse
Lawrence S
LS
Werner
John S
JS
Park
Susanna S
SS
D000328:Adult; D000368:Aged; D001826:Body Fluids; D017679:Cryotherapy; D005122:Exudates and Transudates; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008266:Macula Lutea / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology*; D011446:Prospective Studies; D012163:Retinal Detachment / Q000503:physiopathology* / Q000601:surgery*; D012591:Scleral Buckling; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology; D014821:Vitrectomy