title: [Physiopathology of sarcoidosis].
abstract: Sarcoidosis results from an uncontrolled cell-mediated immune reaction involving activated T cells and monocytes-macrophages, characterized by the formation of typical granulomas at the sites of the lesions. The interactions between both cell types induce the release of several mediators that play a central role in the development of granulomas, allowing to design new therapies. The aetiology of sarcoidosis remains unknown, but the disease is currently viewed as the consequence of a chronic immunological response associating a genetic susceptibility and specific environmental factors.
authors.affiliation: Inserm U700, Université Paris Diderot, Paris 7 UFR de médecine-site Bichat, 75870 Paris Cedex 18, France. paul.soler@inserm.fr
authors.forename: Paul
authors.initials: P
authors.lastname: Soler
mesh_terms: D016207:Cytokines / Q000378:metabolism; D004777:Environment; D020022:Genetic Predisposition to Disease; D006099:Granuloma / Q000503:physiopathology; D006801:Humans; D012507:Sarcoidosis / Q000209:etiology / Q000503:physiopathology*
chemical_list: D016207:Cytokines