Argusides D and E, two new cytotoxic triterpene glycosides from the sea cucumber Bohadschia argus Jaeger.
Two new triterpene glycosides, argusides D and E (1 and 2, resp.), have been isolated from the sea cucumber Bohadschia argus Jaeger collected in the South China Sea. Their structures have been established by spectral analysis (ESI-MS, and 1D- and 2D-NMR) and chemical evidence. Compounds 1 and 2 both possess an holostane-type triterpene aglycone with a C(9)=C(11) bond, an OH group at C(12), and tetrasaccharide moieties, but differ in the side chains. The two glycosides exhibited significant cytotoxicities against four human tumor cell lines, A549, HCT-116, HepG2, and MCF-7.
Liu
Bao-Shu
BS
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P. R. China.
Yi
Yang-Hua
YH
Li
Ling
L
Sun
Peng
P
Han
Hua
H
Sun
Guo-Quan
GQ
Wang
Xiao-Hua
XH
Wang
Zeng-Lei
ZL
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D019906:Nuclear Magnetic Resonance, Biomolecular; D012616:Sea Cucumbers / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D006027:Glycosides; D014315:Triterpenes; C531479:arguside D; C531480:arguside E