Microscale chiral HPLC in support of pharmaceutical process research.
Some recent developments in the use of microscale chiral HPLC for supporting pharmaceutical process research are reviewed, including multiparallel high throughput analysis to support high throughput experimentation studies, rapid multiparallel chromatographic method development, and on-line reaction monitoring. Green chemistry advantages of the approach include greatly reduced solvent consumption, waste generation, and stationary phase requirement relative to conventional chiral HPLC.
Welch
Christopher J
CJ
Separation and Purification Center of Excellence, Merck & Co., Rahway, New Jersy 07065, USA. christopher_welch@merck.com
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D055808:Drug Discovery; D055772:Green Chemistry Technology; D009862:Online Systems; D013237:Stereoisomerism