title: MicroRNAs: key players in carcinogenesis and novel therapeutic targets.
abstract: MicroRNAs (miRNAs) represent a recently uncovered class of small and endogenous non-coding RNAs. MiRNA function is critical to normal cellular processes such as differentiation and apoptosis, and recent studies have demonstrated that deregulated miRNA expression contributes to the malignant phenotype. The purpose of this review is to summarise these findings in relation to the most common human malignancies, and to analyse the clinical and therapeutic opportunities they provide.
authors.affiliation: University Surgical Unit, Level F Centre Block, Southampton General Hospital, Southampton, UK. ahm@soton.ac.uk
authors.forename: A H F
authors.initials: AH
authors.lastname: Mirnezami
authors.forename: K
authors.initials: K
authors.lastname: Pickard
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: J N
authors.initials: JN
authors.lastname: Primrose
authors.forename: G
authors.initials: G
authors.lastname: Packham
mesh_terms: D017209:Apoptosis / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics / Q000628:therapy; D002454:Cell Differentiation / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics / Q000628:therapy; D005260:Female; D020869:Gene Expression Profiling; D015316:Genetic Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000628:therapy; D008297:Male; D035683:MicroRNAs / Q000032:analysis* / Q000145:classification / Q000187:drug effects*; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics / Q000628:therapy; D009626:Terminology as Topic
chemical_list: D035683:MicroRNAs