title: Resting energy expenditure and glucose, protein and fat oxidation in severe chronic virus hepatitis B patients.
abstract: OBJECTIVE
  To study and determine the resting energy expenditure (REE) and oxidation rates of glucose, fat and protein in severe chronic hepatitis B patients.
  
  
  METHODS
  A total of 100 patients with liver diseases were categorized into three groups: 16 in the acute hepatitis group, 56 in the severe chronic hepatitis group, and 28 in the cirrhosis group. The REE and the oxidation rates of glucose, fat and protein were assessed by indirect heat measurement using the CCM-D nutritive metabolic investigation system.
  
  
  RESULTS
  The REE of the severe chronic hepatitis group (20.7 +/- 6.1 kcal/d per kg) was significantly lower than that of the acute hepatitis group (P = 0.014). The respiratory quotient (RQ) of the severe chronic hepatitis group (0.84 +/- 0.06) was significantly lower than that of the acute hepatitis and cirrhosis groups (P = 0.001). The glucose oxidation rate of the severe hepatitis group (39.2%) was significantly lower than that of the acute hepatitis group and the cirrhosis group (P < 0.05), while the fat oxidation rate (39.8%) in the severe hepatitis group was markedly higher than that of the other two groups (P < 0.05). With improvement of liver function, the glucose oxidation rate increased from 41.7% to 60.1%, while the fat oxidation rate decreased from 26.3% to 7.6%.
  
  
  CONCLUSIONS
  The glucose oxidation rate is significantly decreased, and a high proportion of energy is provided by fat in severe chronic hepatitis. These results warrant a large clinical trail to assess the optimal nutritive support therapy for patients with severe liver disease.
authors.affiliation: Department of Gastroenterology and Hepatology, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Chun-Lei
authors.initials: CL
authors.lastname: Fan
authors.forename: Yan-Jing
authors.initials: YJ
authors.lastname: Wu
authors.forename: Zhong-Ping
authors.initials: ZP
authors.lastname: Duan
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Pei-Ling
authors.initials: PL
authors.lastname: Dong
authors.forename: Hui-Guo
authors.initials: HG
authors.lastname: Ding
mesh_terms: D000328:Adult; D018450:Disease Progression; D004734:Energy Metabolism; D005223:Fats / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D019694:Hepatitis B, Chronic / Q000378:metabolism* / Q000821:virology; D006801:Humans; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*
chemical_list: D005223:Fats; D011506:Proteins; D005947:Glucose; D010100:Oxygen