Ion-sensitive "isothermal" responsive polymers prepared in water.
Ion-sensitive responsive polymers are prepared under fully aqueous conditions using controlled radical polymerization. Variations in comonomer content and sequence lead to temperature and salt-dependent solution behavior, with cloud-points ranging by +/-40 degrees C following addition of Hofmeister series salts. A "hybrid" block copolymer, composed of a statistical sequence of monomers tipped with a hydrophilic block, formed stable micelle-like assemblies that exhibited burst release of an encapsulated model drug in response to addition of a kosmotrope, Na2SO4, at room temperature.
Magnusson
Johannes Pall
JP
School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Khan
Adnan
A
Pasparakis
George
G
Saeed
Aram Omer
AO
Wang
Wenxin
W
Alexander
Cameron
C
D007477:Ions / Q000737:chemistry; D008689:Methacrylates / Q000138:chemical synthesis* / Q000737:chemistry; D008823:Micelles; D015394:Molecular Structure; D010316:Particle Size; D044367:Phase Transition; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry; D012492:Salts / Q000737:chemistry; D012680:Sensitivity and Specificity; D013696:Temperature; D013997:Time Factors; D014867:Water / Q000737:chemistry*
D007477:Ions; D008689:Methacrylates; D008823:Micelles; D012492:Salts; C421283:poly(ethylene glycol)-dimethacrylate; C524499:polyethylene glycol methacrylate; D014867:Water; D011092:Polyethylene Glycols