Brain maps of Iowa gambling task.
BACKGROUND
Somatic Marker Hypothesis (SMH), based on clinical observations, delineates neuronal networks for interpreting consciousness generation and decision-making. The Iowa gambling task (IGT) was designed to verify the SMH. However, more and more behavioral and brain imaging studies had reported incongruent results that pinpointed a need to re-evaluate the central representations of SMH. The current study used event-related fMRI (functional Magnetic Resonance Imaging) to examine neural correlates of anticipation vs. outcome, wins vs. losses, and differential decks' contingencies of IGT.


RESULTS
Behavioral results showed a prominent effect of frequency in driving choices. The insula and basal ganglia were activated during the anticipation phase while the inferior parietal lobule was activated during the outcome phase. The activation of medial prefrontal cortex was especially targeted during the high punishment contingencies. The data suggest that under uncertainty the normal decision makers can become myopic.


CONCLUSIONS
The insula and basal ganglia might play a vital role in long-term guidance of decision-making. Inferior parietal lobule might participate in evaluating the consequence and medial prefrontal cortex may service the function of error monitoring.
Lin
Ching-Hung
CH
Institute of Neuroscience, School of Life Science, National Yang-Ming University, Taipei, Taiwan. eandy924@ms42.hinet.net
Chiu
Yao-Chu
YC
Cheng
Chou-Ming
CM
Hsieh
Jen-Chuen
JC
D000328:Adult; D001479:Basal Ganglia / Q000502:physiology; D001921:Brain / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology; D003657:Decision Making / Q000502:physiology*; D004644:Emotions / Q000502:physiology; D005260:Female; D005715:Gambling / Q000523:psychology*; D005717:Games, Experimental; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000502:physiology; D017397:Prefrontal Cortex / Q000502:physiology; D011582:Psychological Theory; D011678:Punishment / Q000523:psychology; D012309:Risk-Taking