title: Preparation of levodopa-2, 6-dimethyl-beta-cyclodextrin inclusion by saturation solution process.
abstract: Levodopa-2,6-Dimethyl-beta-Cyclodextrin inclusion was prepared by saturation solution process for nasal administration. The best inclusion technology was screened out with orthogonal design by the alteration of the experimental conditions, such as temperature, stir speed, and ratio of levodopa to 2,6-Dimethyl-beta-Cyclodextrin. The yield and content of levodopa inclusion complex prepared by the saturation solution method were 76.76% and 16.83%, respectively; the inclusion condition involved that the mol ratio of levodopa to 2,6-Dimethyl-beta-Cyclodextrin was 1:1, stir temperature was 40 degrees C, inclusion time was 4 hours, and stir speed was 300 rpm. This method is simple and easy to operate.
authors.affiliation: Faculty of Pharmacy, Medical College, Qingdao University, Qingdao, China. yong.sun@vip.sina.com
authors.forename: Yong
authors.initials: Y
authors.lastname: Sun
authors.forename: Lisa
authors.initials: L
authors.lastname: Xu
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
authors.forename: Baohua
authors.initials: B
authors.lastname: Ma
mesh_terms: D000281:Administration, Intranasal; D002152:Calorimetry, Differential Scanning; D002855:Chromatography, Thin Layer; D007980:Levodopa / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D012995:Solubility; D019265:Spectroscopy, Near-Infrared; D047392:beta-Cyclodextrins / Q000008:administration & dosage / Q000138:chemical synthesis*
chemical_list: D047392:beta-Cyclodextrins; C531158:levodopa-2,6-dimethyl-beta-cyclodextrin; D007980:Levodopa