The colocalization transition of homologous chromosomes at meiosis.
Meiosis is the specialized cell division required in sexual reproduction. During its early stages, in the mother cell nucleus, homologous chromosomes recognize each other and colocalize in a crucial step that remains one of the most mysterious of meiosis. Starting from recent discoveries on the system molecular components and interactions, we discuss a statistical mechanics model of chromosome early pairing. Binding molecules mediate long-distance interaction of special DNA recognition sequences and, if their concentration exceeds a critical threshold, they induce a spontaneous colocalization transition of chromosomes, otherwise independently diffusing.
Nicodemi
Mario
M
Department of Physics and Complexity Science, University of Warwick, Coventry, United Kingdom.
Panning
Barbara
B
Prisco
Antonella
A
D000818:Animals; D001703:Biophysics / Q000379:methods; D017173:Caenorhabditis elegans; D023902:Chromosome Pairing; D002875:Chromosomes / Q000648:ultrastructure*; D004247:DNA / Q000737:chemistry; D004249:DNA Damage; D004330:Drosophila; D006801:Humans; D007700:Kinetics; D008540:Meiosis; D008954:Models, Biological; D015233:Models, Statistical; D008962:Models, Theoretical; D013816:Thermodynamics
D004247:DNA