Immunomodulatory activity of plant residues on ovine neutrophils.
Neutrophils play an essential role in host defense and inflammation. Plants have long been used to improve the immune function, but for most of them specific investigations on animal health are lacking. In the present study, water and hydroethanolic extracts from 11 plant wastes have been screened on immune responses of ovine neutrophils. Eight sheep clinically healthy, not lactating, non-pregnant were selected and used for the experiment. Freshly isolated neutrophils were incubated with the extracts of the residues at increasing doses, and then they were tested for adhesion and superoxide production induced with PMA. The residues of Larix decidua, Thymus vulgaris, Salix alba, Sinupret, Helianthus annuus, Mangifera indica modulated the neutrophil immune functions, moreover, Larix decidua, Thymus vulgaris and Salix alba presented the highest anti-inflammatory activity.
Farinacci
Maura
M
Department of Scienze Animali, University of Udine, via delle Scienze 208, 33100 Udine, Italy. maura.farinacci@uniud.it
Colitti
Monica
M
Sgorlon
Sandy
S
Stefanon
Bruno
B
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology*; D019684:Magnoliopsida / Q000737:chemistry; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012756:Sheep / Q000097:blood*; D013481:Superoxides / Q000378:metabolism
D007155:Immunologic Factors; D010936:Plant Extracts; D013481:Superoxides