Intraluminal thrombus and risk of rupture in patient specific abdominal aortic aneurysm - FSI modelling.
Recent numerical studies of abdominal aortic aneurysm (AAA) suggest that intraluminal thrombus (ILT) may reduce the stress loading on the aneurysmal wall. Detailed fluid structure interaction (FSI) in the presence and absence of ILT may help predict AAA rupture risk better. Two patients, with varied AAA geometries and ILT structures, were studied and compared in detail. The patient specific 3D geometries were reconstructed from CT scans, and uncoupled FSI approach was applied. Complex flow trajectories within the AAA lumen indicated a viable mechanism for the formation and growth of the ILT. The resulting magnitude and location of the peak wall stresses was dependent on the shape of the AAA, and the ILT appeared to reduce wall stresses for both patients. Accordingly, the inclusion of ILT in stress analysis of AAA is of importance and would likely increase the accuracy of predicting AAA risk of rupture.
Bluestein
Danny
D
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA. danny.bluestein@sunysb.edu
Dumont
Kris
K
De Beule
Matthieu
M
Ricotta
John
J
Impellizzeri
Paul
P
Verhegghe
Benedict
B
Verdonck
Pascal
P
D001012:Aorta, Abdominal / Q000503:physiopathology*; D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D003198:Computer Simulation; D055119:Elastic Modulus; D020342:Finite Element Analysis; D006801:Humans; D008955:Models, Cardiovascular; D018570:Risk Assessment; D012307:Risk Factors; D012422:Rupture, Spontaneous / Q000209:etiology / Q000503:physiopathology; D033081:Shear Strength; D013927:Thrombosis / Q000150:complications* / Q000503:physiopathology*