title: Obesity and adiponectin in acute myocardial infarction.
abstract: BACKGROUND
  Low plasma concentration of adiponectin, a hormone-like peptide secreted by adipose tissue, is detected in obesity and in coronary artery disease. The aim of the study was to assess the impact of obesity on adiponectin and the relation of adiponectin to the anthropometric parameters and cardiovascular risk factors in men with acute myocardial infarction.
  
  
  METHODS
  Two groups of patients with first acute myocardial infarction were analyzed: 40 obese and 40 non-obese men. Waist and hip circumferences and waist-to-hip ratio, C-reactive protein (CRP), uric acid, fasting glucose, lipid profile and adiponectin were measured.
  
  
  RESULTS
  Mean level of adiponectin was significantly lower in obese than non-obese patients (6.80 mug/ml +/- 4.31 vs. 11.18 mug/ml +/- 7.19; p < 0.01). Adiponectin levels correlated negatively with all anthropometric measurements, the most significantly with waist circumference, with systolic blood pressure, fasting glucose, triglyceride levels, CRP, uric acid and positively with age and HDL-cholesterol. Adiponectin level was significantly associated with HDL-cholesterol, waist circumference and with trigliceryde levels and these independent variables explained 39% of the plasma adiponectin variability.
  
  
  CONCLUSIONS
  In patients with acute myocardial infarction obesity is related to decreased adiponectin. Low adiponectin level is associated with atherogenic lipid profile and higher levels of inflammatory markers. (Cardiol J 2007; 14: 29-36).
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Piestrzeniewicz
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Luczak
authors.forename: Jan
authors.initials: J
authors.lastname: Komorowski
authors.forename: Marek
authors.initials: M
authors.lastname: Maciejewski
authors.forename: Monika
authors.initials: M
authors.lastname: Piechowiak
authors.forename: Joanna
authors.initials: J
authors.lastname: Jankiewicz-Wika
authors.forename: Jan Henryk
authors.initials: JH
authors.lastname: Goch