Sequencing of new HLA-A*3025 and HLA-Cw*0221 alleles found in Caucasian donors.
Two new human leukocyte antigen (HLA) class I alleles, A*3025 and Cw*0221, were identified in Spanish Caucasian donors by polymerase chain reaction-sequence-specific oligonucleotide and subsequently characterized by full coding region sequencing. HLA-A*3025 shows a single amino acid replacement at residue 70 (H>Q) compared with A*300201. HLA-Cw*0221 differs from Cw*020202 by a change at position 14 (H>Q).
Balas
A
A
Departamento de Histocompatibilidad, Centro de Transfusión de la Comunidad de Madrid, Madrid, Spain. abalas.trans@salud.madrid.org
Sánchez-Gordo
F
F
Bustamante
L
L
García-Sánchez
F
F
Vicario
J L
JL
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D015234:HLA-A Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D044465:White People / Q000235:genetics
D015234:HLA-A Antigens; D015236:HLA-C Antigens