title: 14th International HLA and Immunogenetics Workshop Prospective Chronic Rejection Project: a three-year follow-up analysis.
abstract: The three-year follow-up of 4,144 patients of the 14th International Workshop Prospective Chronic Rejection study has reinforced the evidence that post-transplant HLA antibodies are predictive of long-term graft loss. Three years after a single testing for HLA antibodies, 10% of kidney recipients who were antibody-positive had lost their grafts, in contrast to only 5% of antibody-negative patients (p<0.0001). The adverse effect of post-transplant antibodies on graft survival was also observed in lung, heart, and liver transplants. Donor-specific antibodies and 'strong' non-DSA had stronger association with graft loss than 'moderate' non-DSA. Periodic antibody monitoring, combined with specificity and strength analysis, would help in the early identification of allograft recipients who are at high risk of graft failure.
authors.affiliation: One Lambda, Inc., Los Angeles, CA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Ozawa
authors.forename: P I
authors.initials: PI
authors.lastname: Terasaki
authors.forename: R
authors.initials: R
authors.lastname: Castro
authors.forename: J
authors.initials: J
authors.lastname: Alberu
authors.forename: L
authors.initials: L
authors.lastname: Morales-Buenrostro
authors.forename: I
authors.initials: I
authors.lastname: Alvarez
authors.forename: R
authors.initials: R
authors.lastname: Toledo
authors.forename: H
authors.initials: H
authors.lastname: Alvez
authors.forename: M
authors.initials: M
authors.lastname: Monteiro
authors.forename: J
authors.initials: J
authors.lastname: Teixeira
authors.forename: P
authors.initials: P
authors.lastname: Campbell
authors.forename: M
authors.initials: M
authors.lastname: Ciszek
authors.forename: D
authors.initials: D
authors.lastname: Charron
authors.forename: C
authors.initials: C
authors.lastname: Gautreau
authors.forename: F
authors.initials: F
authors.lastname: Christiansen
authors.forename: L
authors.initials: L
authors.lastname: Langan
authors.forename: R
authors.initials: R
authors.lastname: Conca
authors.forename: H
authors.initials: H
authors.lastname: Grosse-Wilde
authors.forename: F
authors.initials: F
authors.lastname: Heinemann
authors.forename: M
authors.initials: M
authors.lastname: Kamoun
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: P
authors.initials: P
authors.lastname: Kupatawintu
authors.forename: W
authors.initials: W
authors.lastname: LeFor
authors.forename: N
authors.initials: N
authors.lastname: Mehra
authors.forename: A
authors.initials: A
authors.lastname: Panigrahi
authors.forename: D
authors.initials: D
authors.lastname: Norman
authors.forename: A
authors.initials: A
authors.lastname: Piazza
authors.forename: F
authors.initials: F
authors.lastname: Poli
authors.forename: R
authors.initials: R
authors.lastname: Roy
authors.forename: C
authors.initials: C
authors.lastname: Schonemann
authors.forename: N
authors.initials: N
authors.lastname: Lachmann
authors.forename: G
authors.initials: G
authors.lastname: Sireci
authors.forename: K
authors.initials: K
authors.lastname: Tanabe
authors.forename: H
authors.initials: H
authors.lastname: Ishida
authors.forename: E
authors.initials: E
authors.lastname: Van den Berg-Loonen
authors.forename: A
authors.initials: A
authors.lastname: Zeevi
mesh_terms: D002908:Chronic Disease; D004493:Education; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000276:immunology*; D006085:Graft Survival / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D016027:Heart Transplantation / Q000276:immunology / Q000706:statistics & numerical data; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000276:immunology / Q000706:statistics & numerical data; D016040:Lung Transplantation / Q000276:immunology / Q000706:statistics & numerical data; D016377:Organ Transplantation / Q000706:statistics & numerical data*; D011446:Prospective Studies
chemical_list: D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A