Improving platinum(II)-based anticancer drug delivery using cucurbit[n]urils.
Despite the synthesis of hundreds of new platinum(II) and platinum(IV)-based complexes each year as potential anticancer drugs, only three have received world-wide approval: cisplatin, carboplatin and oxaliplatin. The next big advance in platinum-based chemotherapy is not likely to come from the development of new drugs, but from the controlled and targeted delivery of already approved drugs or those in late stage clinical trials. Encapsulation of platinum drugs inside macromolecules has already demonstrated promise, and encapsulation within cucurbit[n]urils has shown particular potential. Partial or full encapsulation within cucurbit[n]urils provides steric hindrance to drug degradation by peptides and proteins, and the use of different sized cucurbit[n]urils allows for the tuning of drug release rates, cytotoxicity and toxicity.
Wheate
Nial J
NJ
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, United Kingdom. nial.wheate@strath.ac.uk
D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage* / Q000737:chemistry; D001952:Bridged-Ring Compounds / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D011756:Diphosphates / Q000008:administration & dosage* / Q000737:chemistry; D004338:Drug Combinations; D016503:Drug Delivery Systems; D006801:Humans; D007938:Leukemia / Q000378:metabolism; D051379:Mice; D011095:Polyethylenes / Q000008:administration & dosage* / Q000737:chemistry
D016588:Anticarcinogenic Agents; D001952:Bridged-Ring Compounds; D011756:Diphosphates; D004338:Drug Combinations; C098979:Platinum Dentifrice; D011095:Polyethylenes