The TACC proteins: TACC-ling microtubule dynamics and centrosome function.
A major quest in cell biology is to understand the molecular mechanisms underlying the high plasticity of the microtubule network at different stages of the cell cycle, and during and after differentiation. Initial reports described the centrosomal localization of proteins possessing transforming acidic coiled-coil (TACC) domains. This discovery prompted several groups to examine the role of TACC proteins during cell division, leading to indications that they are important players in this complex process in different organisms. Here, we review the current understanding of the role of TACC proteins in the regulation of microtubule dynamics, and we highlight the complexity of centrosome function.
Peset
Isabel
I
Cell and Developmental Biology Program, Centre for Genomic Regulation (CRG), University Pompeu Fabra (UPF), Dr Aiguader 88, Barcelona 08003, Spain. isabel.peset@crg.es
Vernos
Isabelle
I
D000818:Animals; D002352:Carrier Proteins; D002455:Cell Division; D018385:Centrosome / Q000502:physiology*; D005326:Fetal Proteins; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D008870:Microtubules / Q000502:physiology; D009687:Nuclear Proteins; D025521:Tumor Suppressor Proteins
D002352:Carrier Proteins; D005326:Fetal Proteins; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins; C120584:TACC1 protein, human; C410333:TACC2 protein, human; C120551:TACC3 protein, human; D025521:Tumor Suppressor Proteins