title: [Significance of bone marrow endothelial progenitor cells in disturbance of angiogenesis and endothelial dysfunction in systemic scleroderma].
abstract: The study is aimed to investigate the process of endothelial repair related to endothelial progenitor cells (EPC) in systemic sclerosis (SS), and analyze the role of EPC abnormalities in endothelial dysfunction and impaired angiogenesis. Correlation between EPC circulating levels, measured by flowcytometry, and peripheral vascular manifestations, cardiac involvement, carotid artery disease, Framingham risk factor score, endothelial function and morphological signs of microangiopathy is explored. Our data demonstrate, that EPC reduction with disease progression is closely linked with endothelial dysfunction and destructive microangiopathy, and significantly contribute into development of severe cardiac disease and pulmonary hypertension in SS patients.
authors.forename: T A
authors.initials: TA
authors.lastname: Nevskaia
authors.forename: L P
authors.initials: LP
authors.lastname: Anan'eva
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Bykovskaia
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Lysiuk
authors.forename: M E
authors.initials: ME
authors.lastname: Zapriagaeva
authors.forename: R T
authors.initials: RT
authors.lastname: Alekperov
authors.forename: M N
authors.initials: MN
authors.lastname: Starovoĭtova
authors.forename: E S
authors.initials: ES
authors.lastname: Mach
authors.forename: N G
authors.initials: NG
authors.lastname: Guseva
authors.forename: E L
authors.initials: EL
authors.lastname: Nasonov
mesh_terms: D000328:Adult; D000886:Anthropometry; D001853:Bone Marrow / Q000378:metabolism*; D002340:Carotid Artery Diseases / Q000453:epidemiology / Q000503:physiopathology; D018450:Disease Progression; D004727:Endothelium / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000453:epidemiology*; D012595:Scleroderma, Systemic / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D013234:Stem Cells / Q000378:metabolism*