Role of C-Peptide in the regulation of microvascular blood flow.
During the recent years, the role of C-peptide, released from the pancreatic beta cell, in regulating microvascular blood flow, has received increasing attention. In type 1 diabetic patients, intravenous application of C-peptide in physiological concentrations was shown to increase microvascular blood flow, and to improve microvascular endothelial function and the endothelial release of NO. C-peptide was shown to impact microvascular blood flow by several interactive pathways, like stimulating Na(+)K(+)ATPase or the endothelial release of NO. There is increasing evidence, that in patients with declining beta cell function, the lack of C-peptide secretion might play a putative role in the development of microvascular blood flow abnormalities, which go beyond the effects of declining insulin secretion or increased blood glucose levels.
Forst
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Medical Department, Institute for Clinical Research and Development, 55116 Mainz, Germany. thomasf@ikfe.de
Kunt
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T
Wilhelm
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Weber
M M
MM
Pfützner
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A
D001783:Blood Flow Velocity / Q000502:physiology*; D002096:C-Peptide / Q000502:physiology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000502:physiology / Q000503:physiopathology; D004907:Erythrocyte Deformability / Q000502:physiology; D006801:Humans; D008833:Microcirculation / Q000502:physiology*; D009569:Nitric Oxide / Q000502:physiology
D002096:C-Peptide; D009569:Nitric Oxide