title: Which treatment for nonalcoholic fatty liver disease?
abstract: Subjects with nonalcoholic fatty liver disease are at risk of progressive liver failure. Lifestyle changes including weight-loss strategies and increased physical activity remain the first-line approach, but a few pharmacological treatments have also been successfully tested. Several drugs improve biochemistry, only a few improve histology; in all cases, the results were not sustained after treatment stop. Pharmacological treatment is not so far indicated outside controlled clinical trials with histological outcomes.
authors.affiliation: Unit of Clinical Dietetics, "Alma Mater Studiorum" University of Bologna, Policlinico S. Orsola, Via Massarenti, 9, I-40138 Bologna, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Moscatiello
authors.forename: R
authors.initials: R
authors.lastname: Marzocchi
authors.forename: N
authors.initials: N
authors.lastname: Villanova
authors.forename: E
authors.initials: E
authors.lastname: Bugianesi
authors.forename: G
authors.initials: G
authors.lastname: Marchesini
mesh_terms: D000438:Alcohols / Q000009:adverse effects; D000818:Animals; D005234:Fatty Liver / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D024821:Metabolic Syndrome / Q000188:drug therapy; D015431:Weight Loss / Q000187:drug effects
chemical_list: D000438:Alcohols