Importins and exportins in cellular differentiation.
The importin/exportin transport system provides the machinery involved in nucleocytoplasmic transport. Alterations of the levels of importins and exportins may play crucial roles in development, differentiation and transformation. Employing human leukaemia HL-60 cells, we and others have revealed the differentiation-associated changes in the protein and gene expression of these factors. The recent finding that a switch to the importin-alpha subtype triggers neural differentiation of embryonic stem cells underscores the importance of nucleocytoplasmic transport factors in cellular events. This review focuses on current research into the roles of importins and exportins in cell differentiation.
Okada
Norihisa
N
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan.
Ishigami
Yoko
Y
Suzuki
Takuji
T
Kaneko
Akihiro
A
Yasui
Kensuke
K
Fukutomi
Ryuuta
R
Isemura
Mamoru
M
D021581:Active Transport, Cell Nucleus / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics*; D002467:Cell Nucleus / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D018922:HL-60 Cells; D006801:Humans; D028884:Karyopherins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological
D028884:Karyopherins