Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology.
Drugs and food exert their reinforcing effects in part by increasing dopamine (DA) in limbic regions, which has generated interest in understanding how drug abuse/addiction relates to obesity. Here, we integrate findings from positron emission tomography imaging studies on DA's role in drug abuse/addiction and in obesity and propose a common model for these two conditions. Both in abuse/addiction and in obesity, there is an enhanced value of one type of reinforcer (drugs and food, respectively) at the expense of other reinforcers, which is a consequence of conditioned learning and resetting of reward thresholds secondary to repeated stimulation by drugs (abuse/addiction) and by large quantities of palatable food (obesity) in vulnerable individuals (i.e. genetic factors). In this model, during exposure to the reinforcer or to conditioned cues, the expected reward (processed by memory circuits) overactivates the reward and motivation circuits while inhibiting the cognitive control circuit, resulting in an inability to inhibit the drive to consume the drug or food despite attempts to do so. These neuronal circuits, which are modulated by DA, interact with one another so that disruption in one circuit can be buffered by another, which highlights the need of multiprong approaches in the treatment of addiction and obesity.
Volkow
Nora D
ND
National Institute on Drug Abuse, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA. nvolkow@nida.nih.gov
Wang
Gene-Jack
GJ
Fowler
Joanna S
JS
Telang
Frank
F
D003213:Conditioning, Psychological / Q000502:physiology; D004298:Dopamine / Q000378:metabolism*; D004435:Eating; D006801:Humans; D007858:Learning / Q000502:physiology; D008954:Models, Biological; D009434:Neural Pathways / Q000473:pathology*; D009765:Obesity / Q000473:pathology*; D019966:Substance-Related Disorders / Q000473:pathology*
D004298:Dopamine