Taxodione, a DNA-binding compound from Taxodium distichum L. (Rich.).
8-beta-Hydroxypimar-15-en-19-oic acid (1), taxodione (2), 6,7-dehydro-8-hydrotaxodone (3), quercetin-3-O-beta-D-glucopyranoside (4), and shikimic acid (5) were isolated from the leaves of Taxodium distichum L. (Rich.) for the first time. Previously reported compounds [beta-sitosterol (6), isorhamnetin (7), quercetin (8), isorhamnetin-3-O-alpha-arabinofuranoside (9), quercetin-3-O-a-arabinofuranoside (10)] have also been isolated. The activity of taxodione as an inhibitor for hepatic stellate cells was determined. The antitumour activity of 2, 3, and 5 using a DNA affinity probe was examined.
Zaghloul
Ahmed M
AM
Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Gohar
Ahmed A
AA
Naiem
Zein Al-abdin M
ZA
Abdel Bar
Fatma M
FM
D000818:Animals; D001665:Binding Sites; D004247:DNA / Q000378:metabolism; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D044948:Flavonols / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D008099:Liver / Q000166:cytology / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry*; D011794:Quercetin; D051381:Rats; D012997:Solvents; D032489:Taxodium / Q000737:chemistry*
D004224:Diterpenes; D044948:Flavonols; D006027:Glycosides; D012997:Solvents; D004247:DNA; D011794:Quercetin; C009387:taxodione