title: A genome-wide linkage scan for age at menarche in three populations of European descent.
abstract: BACKGROUND
  Age at menarche (AAM) is an important trait both biologically and socially, a clearly defined event in female pubertal development, and has been associated with many clinically significant phenotypes.
  
  
  OBJECTIVE
  The objective of the study was to identify genetic loci influencing variation in AAM in large population-based samples from three countries.
  
  
  METHODS
  Recalled AAM data were collected from 13,697 individuals and 4,899 pseudoindependent sister-pairs from three different populations (Australia, The Netherlands, and the United Kingdom) by mailed questionnaire or interview. Genome-wide variance components linkage analysis was implemented on each sample individually and in combination.
  
  
  RESULTS
  The mean, sd, and heritability of AAM across the three samples was 13.1 yr, 1.5 yr, and 0.69, respectively. No loci were detected that reached genome-wide significance in the combined analysis, but a suggestive locus was detected on chromosome 12 (logarithm of the odds = 2.0). Three loci of suggestive significance were seen in the U.K. sample on chromosomes 1, 4, and 18 (logarithm of the odds = 2.4, 2.2 and 3.2, respectively).
  
  
  CONCLUSIONS
  There was no evidence for common highly penetrant variants influencing AAM. Linkage and association suggest that one trait locus for AAM is located on chromosome 12, but further studies are required to replicate these results.
authors.affiliation: Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland 4029, Australia.
authors.forename: Carl A
authors.initials: CA
authors.lastname: Anderson
authors.forename: Gu
authors.initials: G
authors.lastname: Zhu
authors.forename: Mario
authors.initials: M
authors.lastname: Falchi
authors.forename: Stéphanie M
authors.initials: SM
authors.lastname: van den Berg
authors.forename: Susan A
authors.initials: SA
authors.lastname: Treloar
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Spector
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
authors.forename: Dorret I
authors.initials: DI
authors.lastname: Boomsma
authors.forename: Peter M
authors.initials: PM
authors.lastname: Visscher
authors.forename: Grant W
authors.initials: GW
authors.lastname: Montgomery
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001315:Australia; D002648:Child; D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D005828:Genetics, Population; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008572:Menarche / Q000208:ethnology / Q000235:genetics* / Q000502:physiology; D009426:Netherlands; D035781:Siblings; D014427:Twins / Q000235:genetics; D006113:United Kingdom; D044465:White People / Q000235:genetics*