title: Detection of significant coronary artery stenosis with 64-slice computed tomography in heart transplant recipients: a comparative study with conventional coronary angiography.
abstract: OBJECTIVE
  The present study evaluates clinical feasibility of cardiac multidetector computed tomography angiography (MDCTA) to detect significant stenosis of coronary vessels due to transplant vasculopathy (TVP) after heart transplantation (HTx).
  
  
  METHODS
  Twenty-eight consecutive male HTx-recipients scheduled for their annual routine conventional coronary angiography (CCA) additionally underwent 64-slice MDCTA.
  
  
  RESULTS
  Two patients were excluded from further MDCTA analysis. Out of 371 remaining coronary vessel segments evaluable by CCA, MDCTA was able to depict 302 (81.4%) in diagnostic image quality. On a segment based analysis, sensitivity, specificity, diagnostic accuracy (DA), negative predictive value (NPV), and positive predictive value (PPV) for detection of significant stenosis were calculated with 87.5%, 97.3%, 97.0%, 99.7%, and 46.7%, respectively. On a patient-based evaluation, sensitivity, specificity, DA, NPV, PPV were 100%, 81%, 84.6%, 100% and 55.6%, respectively. Evaluation of stenosis degree by MDCTA showed systematic overestimation of 4.4%. A moderate to good agreement comparing both modalities was found (Pearson's correlation coefficient: 0.64).
  
  
  CONCLUSIONS
  High NPV suggesting 64-slice MDCTA being a reliable diagnostic tool for ruling out significant stenosis due to TVP in HTx patients. But its clinical value in these particular patients needs further investigation.
authors.affiliation: Department of Cardiology, Ludwig-Maximilians-University, Grosshadern Campus, Munich, Germany. franz.ziegler@med.uni-muenchen.de
authors.forename: Franz
authors.initials: F
authors.lastname: von Ziegler
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Leber
authors.forename: Alexander
authors.initials: A
authors.lastname: Becker
authors.forename: Ingo
authors.initials: I
authors.lastname: Kaczmarek
authors.forename: Ulf
authors.initials: U
authors.lastname: Schönermarck
authors.forename: Christine
authors.initials: C
authors.lastname: Raps
authors.forename: Janine
authors.initials: J
authors.lastname: Tittus
authors.forename: Peter
authors.initials: P
authors.lastname: Uberfuhr
authors.forename: Christoph R
authors.initials: CR
authors.lastname: Becker
authors.forename: Maximilian
authors.initials: M
authors.lastname: Reiser
authors.forename: Gerhard
authors.initials: G
authors.lastname: Steinbeck
authors.forename: Andreas
authors.initials: A
authors.lastname: Knez
mesh_terms: D017023:Coronary Angiography / Q000379:methods*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D011857:Radiographic Image Interpretation, Computer-Assisted; D012044:Regression Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*