title: Total synthesis of malformin C, an inhibitor of bleomycin-induced G2 arrest.
abstract: Total synthesis of a fungal cyclic peptide, malformin C, recently rediscovered as a G2 checkpoint inhibitor was completed. Our synthesis involved a convergent approach with respect to a linear pentapeptide, cyclization, and oxidative disulfide formation.
authors.affiliation: Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kojima
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Sunazuka
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Nagai
authors.forename: Khachatur
authors.initials: K
authors.lastname: Julfakyan
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukuda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D001761:Bleomycin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D003500:Cyclization; D004249:DNA Damage / Q000187:drug effects; D004220:Disulfides / Q000737:chemistry; D016195:G2 Phase / Q000187:drug effects*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000903:Antibiotics, Antineoplastic; D004220:Disulfides; D007202:Indicators and Reagents; D010456:Peptides, Cyclic; D001761:Bleomycin; C001675:malformins