title: Synthesis, characterization, and antimalarial activity of novel schiff-base-phenol and naphthalene-amine ligands.
abstract: Emergence of chloroquine (CQ) resistant Plasmodium falciparum strains necessitates discovery of inexpensive antimalarial drugs capable of targeting CQ-resistant strains. Towards this objective, herein we have synthesized and characterized naphthalene-Schiff bases or naphthalene-amine phenols. Among these compounds, 7 demonstrated a significant bioactivity with a half-maximal inhibitory concentration (IC(50)) of 1.7 microM against CQ-resistant Dd2 strains.
authors.affiliation: Mallinckrodt Institute of Radiology, Washington University Medical School, St Louis, MO 63110, USA.
authors.forename: Scott E
authors.initials: SE
authors.lastname: Harpstrite
authors.forename: Silvia D
authors.initials: SD
authors.lastname: Collins
authors.forename: Ana
authors.initials: A
authors.lastname: Oksman
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Goldberg
authors.forename: Vijay
authors.initials: V
authors.lastname: Sharma
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008024:Ligands; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D019800:Phenol / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects; D012545:Schiff Bases / Q000737:chemistry
chemical_list: D000588:Amines; D000962:Antimalarials; D008024:Ligands; D009281:Naphthalenes; D012545:Schiff Bases; C031721:naphthalene; D019800:Phenol