Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM.
The associations of the C825T polymorphism (rs5443) of the G-protein beta3 subunit (GNB3) gene and eight adjacent single nucleotide polymorphisms (SNPs) with diabetes were examined using a Japanese population (n (M/W): 2956 (1335/1621); age: 63.0+/-10.2 years). Fasting plasma glucose (FPG) levels were significantly associated with the C825T polymorphism and two flanking SNPs (rs2301339 and rs5446) (p=0.002, 0.001, and 0.008, respectively). A case-control association study of the C825T polymorphism with diabetes using multiple logistic regression analysis showed a significant association of the genotypes TT+TC with an odds ratio of 0.62 (p=0.008) independent of age, gender, and BMI. The effects of salt consumption on the association were then examined (n=1635). The FPG levels were significantly associated with the C825T polymorphism only in subjects with low salt consumption (<12.44 g/day) (p=0.002). A case-control association study also showed a significant association with diabetes only in subjects with low salt consumption (p=0.006).
Daimon
Makoto
M
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990 9585, Japan. mdaimon@med.id.yamagata-u.ac.jp
Sato
Hidenori
H
Sasaki
Satoshi
S
Toriyama
Sayumi
S
Emi
Mitsuru
M
Muramatsu
Masaaki
M
Hunt
Steven C
SC
Hopkins
Paul N
PN
Karasawa
Shigeru
S
Wada
Kiriko
K
Jimbu
Yumi
Y
Kameda
Wataru
W
Susa
Shinji
S
Oizumi
Toshihide
T
Fukao
Akira
A
Kubota
Isao
I
Kawata
Sumio
S
Kato
Takeo
T
D000368:Aged; D044466:Asian People / Q000235:genetics; D001786:Blood Glucose; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D005215:Fasting; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*
D001786:Blood Glucose; C454420:G-protein beta3 subunit; D017673:Sodium Chloride, Dietary; D020962:Heterotrimeric GTP-Binding Proteins