[Cytogenetic effects in follicular epithelium of thyroid gland under prolonged exposure to gamma-radiation at low-doses].
The forming processes of micronucleated follicular thyrocytes in thyroid gland of mature Wistar rats under exposure to the prolonged low-intensity gamma-radiation with 5 and 50 cGy (dose rates: 25, 400 microGy/h; duration: 55, 80 days) were investigated. The chronic exposure to low-intensity gamma-radiation in both doses invokes the frequency of micronuclated thyrocytes three times higher in comparison with control animals. As a result of the small-sized micronuclei formation prevalence in irradiated group, the average size of micronuclei was 1.4-2 times lower than control values. This phenomenon can be reproduced in model experiments with hemithyroidectomized animals exposured to acute gamma-radiation with 2-4 Gy. The obtained results show high sensitivity of micronucleus test to the early determination of radiation-induced genetic damages in follicular epithelium of thyroid gland.
Ermakova
O V
OV
Pavlov
A V
AV
Korableva
T V
TV
D000818:Animals; D002467:Cell Nucleus / Q000473:pathology / Q000528:radiation effects*; D003582:Cytogenetics; D004307:Dose-Response Relationship, Radiation; D004847:Epithelial Cells / Q000473:pathology / Q000528:radiation effects*; D005720:Gamma Rays; D008297:Male; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000473:pathology / Q000528:radiation effects*; D013997:Time Factors