title: DrugViz: a Cytoscape plugin for visualizing and analyzing small molecule drugs in biological networks.
abstract: CONCLUSIONS
  DrugViz is a Cytoscape plugin that is designed to visualize and analyze small molecules within the framework of the interactome. DrugViz can import drug-target network information in an extended SIF file format to Cytoscape and display the two-dimensional (2D) structures of small molecule nodes in a unified visualization environment. It also can identify small molecule nodes by means of three different 2D structure searching methods, namely isomorphism, substructure and fingerprint-based similarity searches. After selections, users can furthermore conduct a two-side clustering analysis on drugs and targets, which allows for a detailed analysis of the active compounds in the network, and elucidate relationships between these drugs and targets. DrugViz represents a new tool for the analysis of data from chemogenomics, metabolomics and systems biology.
  
  
  BACKGROUND
  DrugViz and data set used in Application are freely available for download at http://202.127.30.184:8080/software.html.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Pudong, Shanghai, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xiong
authors.forename: Ke
authors.initials: K
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.forename: David L
authors.initials: DL
authors.lastname: Burk
authors.forename: Hualiang
authors.initials: H
authors.lastname: Jiang
authors.forename: Jingkang
authors.initials: J
authors.lastname: Shen
mesh_terms: D003196:Computer Graphics; D003198:Computer Simulation; D016208:Databases, Factual; D030562:Databases, Protein; D015195:Drug Design; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D020543:Proteome / Q000378:metabolism; D012984:Software; D014584:User-Computer Interface
chemical_list: D004364:Pharmaceutical Preparations; D020543:Proteome