Trace analysis of dithiocarbamate fungicide residues on fruits and vegetables by hydrophilic interaction liquid chromatography/tandem mass spectrometry.
The simultaneous determination of dithiocarbamate (DTC) fungicide residues on fruits and vegetables was performed by liquid chromatography (LC) on a ZIC-pHILIC column coupled to tandem mass spectrometry (MS/MS). For each DTC subclass, i.e. dimethyldithiocarbamates (DMDs), ethylenebis(dithiocarbamates) (EBDs), and propylenebis(dithiocarbamates) (PBDs), the limits of detection and quantification were approximately 0.001 and 0.005 mg kg(-1), respectively. Recoveries from tomatoes, spiked in the range of 0.05-1 mg kg(-1), averaged between 97 and 101%. Several fruits and vegetables from a local market and different countries of origin (apples, pears, grapes, cherry tomatoes, cocktail tomatoes, cucumbers, tomatoes, tamarillos, papaya, and broccoli) were analyzed by LC/MS/MS, LC/MS, and by the routine CS(2) method. In general, the results obtained by both LC/MS and LC/MS/MS were in good agreement with those obtained by the CS(2) method except for the false positive CS(2) results for broccoli and papaya. The results demonstrate that both LC/MS and LC/MS/MS can be used for routine analyses of DTC residues, whereas LC/MS/MS is more sensitive and selective than LC/MS.
Crnogorac
Goranka
G
Institute of Food Chemistry, University of Hohenheim, Garbenstrasse 28, D-70599 Stuttgart, Germany.
Schmauder
Sabrina
S
Schwack
Wolfgang
W
D002851:Chromatography, High Pressure Liquid; D005506:Food Contamination / Q000032:analysis*; D005638:Fruit / Q000737:chemistry*; D010573:Pesticide Residues / Q000032:analysis*; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods; D013859:Thiocarbamates / Q000032:analysis*; D014675:Vegetables / Q000737:chemistry*
D010573:Pesticide Residues; D013859:Thiocarbamates