Argusides B and C, two new cytotoxic triterpene glycosides from the sea cucumber Bohadschia argus Jaeger.
Two new triterpene glycosides, argusides B and C (1 and 2, resp.), have been isolated from the sea cucumber Bohadschia argus Jaeger collected in the South China Sea. Their structures have been established by spectral analysis (2D-NMR and ESI-MS) and chemical evidence. Compounds 1 and 2 both possess a holostane-type triterpene aglycone with a C(9)==C(11) bond and a OH group at C(12), but differ in their substituents at C(17) and the hexasaccharide moiety. The two glycosides exhibited significant cytotoxicities against four human tumor cell lines (A549, HCT-116, HepG2, and MCF-7). In comparison with the positive control V-16 (etoposide), 1 and 2 showed higher cytotoxicities to A549 and HCT-116 cell lines.
Liu
Bao-Shu
BS
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P. R. China.
Yi
Yang-Hua
YH
Li
Ling
L
Sun
Peng
P
Yuan
Wei-Hua
WH
Sun
Guo-Quan
GQ
Han
Hua
H
Xue
Mei
M
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012616:Sea Cucumbers / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D000970:Antineoplastic Agents; D012503:Saponins; C526076:arguside A