Squalamine: an appropriate strategy against the emergence of multidrug resistant gram-negative bacteria?
We reported that squalamine is a membrane-active molecule that targets the membrane integrity as demonstrated by the ATP release and dye entry. In this context, its activity may depend on the membrane lipid composition. This molecule shows a preserved activity against bacterial pathogens presenting a noticeable multi-resistance phenotype against antibiotics such as polymyxin B. In this context and because of its structure, action and its relative insensitivity to efflux resistance mechanisms, we have demonstrated that squalamine appears as an alternate way to combat MDR pathogens and by pass the gap regarding the failure of new active antibacterial molecules.
Salmi
Chanaz
C
UMR-MD1, Facultés de Médecine et de Pharmacie, Marseille, France.
Loncle
Celine
C
Vidal
Nicolas
N
Letourneux
Yves
Y
Fantini
Jacques
J
Maresca
Marc
M
Taïeb
Nadira
N
Pagès
Jean-Marie
JM
Brunel
Jean Michel
JM
D000255:Adenosine Triphosphate / Q000737:chemistry / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D002777:Cholestanols / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple; D004926:Escherichia coli / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D008055:Lipids / Q000737:chemistry; D008856:Microscopy, Fluorescence / Q000379:methods; D008954:Models, Biological; D008956:Models, Chemical; D010539:Permeability; D010641:Phenotype; D011112:Polymyxin B / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002777:Cholestanols; D008055:Lipids; D000255:Adenosine Triphosphate; C079655:squalamine; D011112:Polymyxin B