Moving known libraries to an addressable array: a site-selective hetero-Michael reaction.
A two-step, Michael reaction-based strategy for site-selectively placing molecules by unique electrodes in an addressable microelectrode array has been developed. The strategy is compatible with the use of polypeptide nucleophiles and works with microelectrode arrays having either 1024 electrodes/cm (2) or 12,544 electrodes/cm (2). The chemistry should allow for the transfer of existing molecular libraries to microelectrode array devices for analysis.
Stuart
Melissae
M
Department of Chemistry, Campus Box 1134, Washington University, St. Louis, Missouri 63130, USA.
Maurer
Karl
K
Moeller
Kevin D
KD
D000595:Amino Acid Sequence; D053000:Analytic Sample Preparation Methods / Q000295:instrumentation*; D004563:Electrochemistry; D046228:Microarray Analysis / Q000295:instrumentation*; D008839:Microelectrodes; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry; D013379:Substrate Specificity
D019151:Peptide Library; D010455:Peptides