Fungal strategies for overcoming host innate immune response.
A successful pathogen is one that is able to effectively survive and evade detection by the host innate immune defense. Fungal pathogens have adopted strategies which evade host defense and eventually cause disease in at-risk patients. Shielding of stimulatory surface recognition molecules, shedding of decoy components, induction of anti-inflammatory signals, complement evasion and resilient survival capacity are successful evasion mechanisms employed by fungal pathogens. Understanding these complex pathways of immune evasion can potentially contribute to development of novel therapeutic strategies against fungal infections.
Chai
Louis Y A
LY
Department of Medicine (463), Radboud Nijmegen University Medical Center, Nijmegen and Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands.
Netea
Mihai G
MG
Vonk
Alieke G
AG
Kullberg
Bart-Jan
BJ
D005658:Fungi / Q000276:immunology* / Q000502:physiology; D006790:Host-Parasite Interactions; D006801:Humans; D007113:Immunity, Innate; D009181:Mycoses / Q000276:immunology* / Q000382:microbiology