title: Intestinal type and endocervical-like ovarian mucinous neoplasms are immunophenotypically distinct entities.
abstract: Ovarian mucinous neoplasm (OMN) is traditionally classified as either intestinal type or endocervical-like subtypes. The 2 subtypes represent different clinicopathologic characteristics. The immunophenotype of the 2 subtypes has not been adequately investigated. In this study, we investigated 14 intestinal type OMNs (borderline and adenocarcinoma) and 12 endocervical-like OMNs (borderline and adenocarcinoma) for their expression of PDX-1, CDX-2, CA-125, CK7, CK20, WT-1, D2-40, and TTF-1. We also included 15 colorectal adenocarcinomas metastatic in the ovary, as they may occasionally mimic OMN. The intestinal type OMNs were positive for PDX-1 (100%), CK7 (100%), CK20 (100%), CDX-2 (29%), whereas were negative for CA-125. The endocervical-like OMNs were positive for CA-125 (100%) and CK7 (100%), whereas were negative for CK20, PDX-1, and CDX-2. Metastatic colorectal adenocarcinomas were positive for CK20 (100%), CDX-2 (100%), and PDX-1 (33%), whereas were negative for CA-125 and CK7. All of the intestinal type and endocervical-like OMNs as well as metastatic colorectal adenocarcinomas were negative for WT-1, D2-40, and TTF-1. Our results demonstrated that the intestinal type and endocervical-like OMNs are immunophenotypically distinct entities. The 2 subtypes can be separated from metastatic colorectal adenocarcinoma by the different immunohistochemical profile of PDX-1, CA-125, CK7, CK20, and CDX-2. In the work-up of mucinous adenocarcinoma in the ovary or abdominal cavity, caution should be exercised in interpreting the possible primary site on the basis of the immunohistochemical profiles.
authors.affiliation: Department of Pathology, Northwestern Memorial Hospital, Northwestern University, Chicago, IL 60611, USA. xlin@northwestern.edu
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Lin
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Lindner
authors.forename: Jan F
authors.initials: JF
authors.lastname: Silverman
authors.forename: Yulin
authors.initials: Y
authors.lastname: Liu
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000145:classification / Q000276:immunology* / Q000473:pathology / Q000556:secondary; D014408:Biomarkers, Tumor / Q000032:analysis / Q000096:biosynthesis; D015179:Colorectal Neoplasms / Q000145:classification / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007414:Intestinal Neoplasms / Q000145:classification / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D010051:Ovarian Neoplasms / Q000145:classification / Q000276:immunology* / Q000473:pathology / Q000556:secondary; D012189:Retrospective Studies; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D014157:Transcription Factors