[Primary hyperparathyroidism as a differential diagnosis of Creutzfeldt-Jakob disease].
We report the case of a 79-years-old woman, hospitalized for a suspicion of Creutzfeldt-Jakob disease because of subacute dementia associated with gait disorder. Laboratory testing revealed elevated serum calcium at 3.51 mmol/l (N=2.25-2.60 mmol/l) caused by a hyperparathyroidism. After symptomatic treatment of hypercalcemia by biphosphonate, cognitive functions as well as the gait disorder improved quickly. A double parathyroid adenoma was removed surgically. Primary hyperparathyroidism is a curable cause of a Creutzfeldt-Jakob like syndrome. Serum calcium should be checked in this clinical setting.
Chadenat
M-L
ML
Service de Neurologie, Hôpital A-Mignot, Centre Hospitalier de Versailles, 1 Rue Richaud, 78000 Versailles, France.
Dalloz
M-A
MA
D'Anglejean
J
J
Fineyre
F
F
Pico
F
F
D000368:Aged; D002118:Calcium / Q000097:blood; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis*; D003704:Dementia / Q000209:etiology; D003937:Diagnosis, Differential; D004569:Electroencephalography; D005260:Female; D020235:Gait Apraxia / Q000209:etiology; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000209:etiology*
D002118:Calcium