title: Cardiovascular events in survivors of high-dose chemotherapy for germ cell tumors.
abstract: The objective was to investigate cardiovascular complications in long-term survivors treated by high-dose chemotherapy. We analyzed 13 previously successfully treated metastatic germ cell cancer patients. The patients ranged in age from 16 to 38 years (median: 27 years). Patients were treated by high-dose ifosfamide, carboplatin and etoposide (ICE) or high-dose etoposide, ifosfamide and cisplatin (VIP). In a minimal follow-up of 48 months, the incidence of cardiovascular events and the accumulated doses of platinum were analyzed from the total amounts of cisplatin and/or carboplatin. The calculated accumulated doses of platinum ranged from 487 to 4302 mg (median: 2297 mg). Cardiovascular events were observed in two patients who received cumulative doses of more than 3000 mg of platinum. Survivors of high-dose chemotherapy may have a risk of developing cardiovascular complications during the early phase of follow-up. In particular, patients who have received carboplatin-based high dose chemotherapy require careful observation.
authors.affiliation: Department of Urology, Saitama Cancer Center, Saitama, Japan. ishioka_ji@yahoo.co.jp
authors.forename: Jun-Ichiro
authors.initials: J
authors.lastname: Ishioka
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Fujii
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kageyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukuda
authors.forename: Yotsuo
authors.initials: Y
authors.lastname: Higashi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kihara
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D016190:Carboplatin / Q000008:administration & dosage* / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy*; D017741:Survivors; D013736:Testicular Neoplasms / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin; D002945:Cisplatin