title: Role of hepatitis B virus, hepatitis D virus and other determinants on suppression of hepatitis C viraemia in HIV infected patients with chronic HCV infection: a longitudinal evaluation.
abstract: The role of hepatitis B virus (HBV) or hepatitis D virus (HDV) coinfections as determinants of hepatitis C virus (HCV) suppression in the setting of HIV-HCV coinfection are poorly understood. Our aim was to assess whether HCV viral replication may be affected by HBV or HDV coinfection in the setting of immunodeficiency driven by HIV.Among the 138 enrolled patients 28(20.3%) tested HCV RNA negative and 110 (79.7%) tested HCV RNA negative. The HCV RNA negative patients showed an higher rate of HBsAg positivity compared with those tested HCVRNA positive [12/28 (42.9%) and 5/110 (4.6%), respectively]. Patients with HCV-HBV-HDV coinfection had the highest chance of having an undetectable HCV RNA (adjusted odds ratio (AOR): 92.0, 95% confidence interval (CI) 5.7-1483.5, p<0.0001). Furthermore, HBV coinfection per se was also found to be independently associated with negative HCV viraemia (AOR: 18.5, 95% CI 2.4-143.5, p<0.0001). HBsAg-positive patients with negative HCV viraemia maintained undetectable levels over time. Our results support a direct role of HBV and HDV coinfections in suppressing HCV viraemia in HIV infected patients. This effect is durable over time, and is not influenced by HAART including anti-HBV drugs.
authors.affiliation: Clinical Department of Infectious Disease, National Institute for Infectious Diseases, L. Spallanzani, Rome, Italy. antonucci@inmi.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Antonucci
authors.forename: Francesco
authors.initials: F
authors.lastname: Vairo
authors.forename: Fabio
authors.initials: F
authors.lastname: Iacomi
authors.forename: Ubaldo Visco
authors.initials: UV
authors.lastname: Comandini
authors.forename: Mariacarmela
authors.initials: M
authors.lastname: Solmone
authors.forename: Pierluca
authors.initials: P
authors.lastname: Piselli
authors.forename: Evangelo
authors.initials: E
authors.lastname: Boumis
authors.forename: Francesco Nicola
authors.initials: FN
authors.lastname: Lauria
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Capobianchi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ippolito
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Puro
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications* / Q000821:virology; D003698:Hepatitis Delta Virus; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D014766:Viremia
chemical_list: D006514:Hepatitis B Surface Antigens; D012367:RNA, Viral