title: Proton MR spectroscopy of the foramen of Monro region in patients with tuberous sclerosis complex.
abstract: OBJECTIVE
  To evaluate with 1H-magnetic resonance spectroscopy (MRS) the metabolites rations of the foramen of Monro's region in patients with tuberous sclerosis complex (TSC).
  
  
  METHODS
  Twelve patients with TSC and an age and gender-matched control group underwent MR imaging at a 1.5T scanner, and 1H-MRS at the foramen of Monro level with a multivoxel acquisition. Similar volumes of interest were selected in each side of the foramen of Monro and in the basal ganglia (lentiform nuclei). The obtained N-acetylaspartate (NAA), creatine (Cr) and choline (Cho) peak amplitude values and ratios were studied. The statistical analysis was performed and p<0.05 was considered statically significant.
  
  
  RESULTS
  There was no significant difference between the NAA/Cr and Cho/Cr ratios near to the foramen of Monro and basal ganglia of the TSC patients compared with the controls (p>0.05).
  
  
  CONCLUSIONS
  The NAA/Cr and Cho/Cr ratios near to the foramen of Monro and basal ganglia of TSC patients are similar to the rations obtained in the control group.
authors.affiliation: Department of Radiology, University of Parana, Curitiba, PR, Brazil. arnolfocarvalho@hotmail.com
authors.forename: Arnolfo de
authors.initials: Ad
authors.lastname: Carvalho-Neto
authors.forename: Isac
authors.initials: I
authors.lastname: Bruck
authors.forename: Sérgio A
authors.initials: SA
authors.lastname: Antoniuk
authors.forename: Edson
authors.initials: E
authors.lastname: Marchiori
authors.forename: Emerson L
authors.initials: EL
authors.lastname: Gasparetto
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001254:Astrocytoma / Q000175:diagnosis / Q000378:metabolism; D001479:Basal Ganglia / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D001923:Brain Chemistry; D016022:Case-Control Studies; D002551:Cerebral Ventricle Neoplasms / Q000378:metabolism*; D002552:Cerebral Ventricles / Q000378:metabolism*; D002648:Child; D002794:Choline / Q000378:metabolism*; D003401:Creatine / Q000032:analysis; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D011446:Prospective Studies; D011522:Protons; D014402:Tuberous Sclerosis / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D014408:Biomarkers, Tumor; D011522:Protons; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline