Target-selective degradation of proteins by porphyrins upon visible photo-irradiation.
A porphyrin derivative effectively and selectively degraded the target transcription factor, human estrogen receptor-alpha (hER-alpha), upon visible light irradiation, in the absence of additives and under neutral conditions.
Tanimoto
Shuho
S
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Matsumura
Shuichi
S
Toshima
Kazunobu
K
D000818:Animals; D002417:Cattle; D002645:Chickens; D047628:Estrogen Receptor alpha / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008027:Light; D009113:Muramidase / Q000737:chemistry / Q000378:metabolism; D010782:Photolysis; D011166:Porphyrins / Q000737:chemistry* / Q000528:radiation effects; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism
C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D011166:Porphyrins; D012710:Serum Albumin, Bovine; D009113:Muramidase