[Effect of combined therapy with hypha Cordyceps and ginkgo leaf tablet on micro-inflammation in patients undergoing maintenance hemodialysis].
OBJECTIVE
To investigate the status of the micro-inflammation in patients undergoing maintenance hemodialysis and the effect of combined therapy with hypha cordyceps and ginkgo leaf tablet for its prevention and treatment.


METHODS
Sixty-five patients undergoing long-term maintenance hemodialysis were randomly assigned to the treated group (33 patients) and the control group (32 patients). Patients in both groups underwent hemodialysis regularly, meanwhile, 3 capsules of Jinshuibao (each capsule containing hypha cordyceps 0.33 g) and 1 tablet of ginkgo leaf tablet (0.23 g/tablet) were additiolally given to the patients in the treated group orally, 3 times per day, and 3 months as 1 treatment course. Their serum inflammatory factors, such as high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), which could reveal the state of microinflammation, were determined before and after treatment. And the same index was also determined in 30 healthy persons allocated in a normal control group.


RESULTS
Compared with the normal control group, the serum levels of hs-CRP (4.94 +/- 2.21 mg/L), IL-6 (0.472 +/- 0.220 microg/L) and TNF-alpha (1.748 +/- 0.724 microg/L) in the treated group were higher before treatment, these indexes decreased markedly after treatment (3.28 +/- 1.28 mg/L, 0.379 +/- 0.163 microg/L, and 1.330 +/- 0.458 microg/L, respectively, all P < 0.01), but without significant change in the control group.


CONCLUSIONS
Micro-inflammation reaction exists popularly in patients undergoing maintenance hemodialysis, and the combined therapy with hypha cordyceps and ginkgo leaf tablet could effectively improve this kind of micro-inflammation reaction.
Huang
Ji-Cang
JC
Department of Nephrology, First Hospital Affiliated to Lanzhou University, Lanzhou. huangjc05@lzu.cn
Li
Jian-Hua
JH
Liu
Tian-Xi
TX
D000328:Adult; D000368:Aged; D032661:Cordyceps / Q000737:chemistry*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry*; D006801:Humans; D025301:Hyphae / Q000737:chemistry*; D007249:Inflammation / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008875:Middle Aged; D018515:Plant Leaves / Q000737:chemistry*; D006435:Renal Dialysis / Q000009:adverse effects*; D013607:Tablets
D004365:Drugs, Chinese Herbal; D018836:Inflammation Mediators; D013607:Tablets