Gene expression profile changes correlated with lymph node metastasis in oral squamous cell carcinoma.
The purpose of this research was to identify biomarkers for predicting cervical lymph node metastasis in oral squamous cell carcinoma (OSCC). We surveyed the expressions of 1289 cancer-related genes in 41 cases of OSCC by cDNA array analysis. We extracted genes upregulated or downregulated in their expression in association with lymph node metastasis. Of 1289 cancer-related genes, we identified 39 genes differentially expressed in OSCC with or without lymph node metastasis. Expression levels of 9 genes were lower, and those of 30 genes were higher, in node-positive cases. The genes expressed at higher levels in node-positive cases included angiogenesis-related molecules, cell adhesion molecules, and proteolytic enzymes. We suggest that these characteristic genes could provide, if verifiable, useful information for predicting the risk of lymph node metastasis in OSCC.
Kashiwazaki
Haruhiko
H
Geriatric Stomatology, Department of Oral Health Science, Graduate School of Dental Medicine, Hokkaido University, N 13 W 7, Kita-ku, Sapporo, 060-8586, Japan. kashi@den.hokudai.ac.jp
Hassan
Nur Mohammad Monsur
NM
Hamada
Jun-Ichi
J
Moriuchi
Tetsuya
T
Yamazaki
Yutaka
Y
Tei
Kanchu
K
Totsuka
Yasunori
Y
Inoue
Nobuo
N
D014408:Biomarkers, Tumor / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D015815:Cell Adhesion Molecules / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics*; D019278:Matrix Metalloproteinase 3 / Q000235:genetics; D020783:Matrix Metalloproteinase 7 / Q000235:genetics; D009062:Mouth Neoplasms / Q000235:genetics*; D009389:Neovascularization, Pathologic / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis
D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D019278:Matrix Metalloproteinase 3; D020783:Matrix Metalloproteinase 7