title: Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: a retrospective analysis.
abstract: BACKGROUND
  Regional anesthesia and analgesia attenuate or prevent perioperative factors that favor minimal residual disease after removal of the primary carcinoma. Therefore, the authors evaluated prostate cancer recurrence in patients who received either general anesthesia with epidural anesthesia/analgesia or general anesthesia with postoperative opioid analgesia.
  
  
  METHODS
  In a retrospective review of medical records, patients with invasive prostatic carcinoma who underwent open radical prostatectomy between January 1994 and December 2003 and had either general anesthesia-epidural analgesia or general anesthesia-opioid analgesia were evaluated through October 2006. The endpoint was an increase in postoperative prostate-specific antigen.
  
  
  RESULTS
  After adjusting for tumor size, Gleason score, preoperative prostate-specific antigen, margin, and date of surgery, the epidural plus general anesthesia group had an estimated 57% (95% confidence interval, 17-78%) lower risk of recurrence compared with the general anesthesia plus opioids group, with a corresponding hazard ratio of 0.43 (95% confidence interval, 0.22-0.83; P = 0.012) in a multivariable Cox regression model. Gleason score and tumor size (percent of prostate involved) were also independent predictors of recurrence (hazards ratios of 1.19 [1.08, 1.52], P = 0.004, and 1.17 [1.03, 1.34] for 10% size difference, P = 0.01, respectively). A similar association between epidural use and recurrence was obtained by comparing patients matched on the propensity to receive epidural versus general anesthesia.
  
  
  CONCLUSIONS
  Open prostatectomy surgery with general anesthesia, substituting epidural analgesia for postoperative opioids, was associated with substantially less risk of biochemical cancer recurrence. Prospective randomized trials to evaluate this association seem warranted.
authors.affiliation: Department of Anaesthesia, Mater Misericordiae University Hospital, The Cleveland Clinic, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Biki
authors.forename: Edward
authors.initials: E
authors.lastname: Mascha
authors.forename: Denis C
authors.initials: DC
authors.lastname: Moriarty
authors.forename: John M
authors.initials: JM
authors.lastname: Fitzpatrick
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Sessler
authors.forename: Donal J
authors.initials: DJ
authors.lastname: Buggy
mesh_terms: D015360:Analgesia, Epidural; D000701:Analgesics, Opioid; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D016001:Confidence Intervals; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D010149:Postoperative Pain / Q000517:prevention & control*; D016016:Proportional Hazards Models; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies
chemical_list: D000701:Analgesics, Opioid