title: The buccal minor salivary glands as starting point for a metastasizing adenocarcinoma--report of a case.
abstract: BACKGROUND
  With the 2005 WHO classification of salivary gland tumours and its increasingly recognized diagnostic entities, the frequency of adenocarcinoma (NOS) has decreased significantly.
  
  
  METHODS
  This paper describes a fast growing adenocarcinoma (NOS), originating from the minor salivary glands of the left buccal mucosa with a rapid onset of multiple local and distant metastases, especially in the lung. A lung primary was unlikely as the tumour was characterized by positivity for cytokeratin 20 and negativity for the thyroid transcription factor-1 protein (TTF-1) in immunohistochemistry.
  
  
  CONCLUSIONS
  A rare case of an adenocarcinoma (NOS) of the minor salivary glands with a rapid development and an unfavourable clinical course is reported. It shows that additional immunohistochemical analysis can decisively contribute to determine the site of the primary tumour in cases with unknown primary.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Muenster University, Germany. et200@gmx.de
authors.forename: Tobias
authors.initials: T
authors.lastname: Ettl
authors.forename: Johannes
authors.initials: J
authors.lastname: Kleinheinz
authors.forename: Ravi
authors.initials: R
authors.lastname: Mehrotra
authors.forename: Stephan
authors.initials: S
authors.lastname: Schwarz
authors.forename: Torsten Eugen
authors.initials: TE
authors.lastname: Reichert
authors.forename: Oliver
authors.initials: O
authors.lastname: Driemel
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000556:secondary*; D000368:Aged; D005260:Female; D006801:Humans; D053554:Keratin-20 / Q000032:analysis; D008175:Lung Neoplasms / Q000276:immunology / Q000556:secondary*; D009362:Neoplasm Metastasis; D009687:Nuclear Proteins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000276:immunology / Q000473:pathology*; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000032:analysis
chemical_list: D053554:Keratin-20; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors