title: Arterial baroreflex function is an important determinant of acute cerebral ischemia in rats with middle cerebral artery occlusion.
abstract: OBJECTIVE
  To clarify whether arterial baroreflex function is an important determinant of acute cerebral ischemia in rats.
  
  
  METHODS
  Three animal models were used in this study. In the first, saponin conjugated with substance P (SP-SAP) was injected into the nucleus tractus solitarii (NTS) of Sprague-Dawley (SD) rats to block the central baroreflex arc. In the second model, sinoaortic denervation (SAD) was performed to destroy the peripheral baroreflex arc in SD rats. In the third model, SD rats were divided into two groups according to their naturally occurring BRS values. After determining hemodynamic indexes and baroreflex sensitivity (BRS), we subjected the animals to middle cerebral artery (MCA) occlusion. Levels of interleukin (IL)-1beta and IL-6 were detected both in SAD/sham operation groups and low/high BRS groups.
  
  
  RESULTS
  In all three animal models, baroreflex dysfunction significantly increased the infarct volume and weight. The levels of inflammatory factors were markedly elevated in SAD and low BRS groups.
  
  
  CONCLUSIONS
  These results demonstrate that the function of arterial baroreflex is an important determinant of acute cerebral ischemia in rats with MCA occlusion. Inflammation might be an important mechanism for the arterial baroreflex dysfunction-induced increase in brain damage in rats with MCA occlusion.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Ling
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Fu-Ming
authors.initials: FM
authors.lastname: Shen
authors.forename: Di-Song
authors.initials: DS
authors.lastname: Wang
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Lin
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Liu
authors.forename: Ding-Feng
authors.initials: DF
authors.lastname: Su
mesh_terms: D000208:Acute Disease; D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D001923:Brain Chemistry / Q000502:physiology; D002545:Brain Ischemia / Q000503:physiopathology*; D002536:Cerebral Arteries / Q000503:physiopathology*; D003714:Denervation; D006339:Heart Rate / Q000502:physiology; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology; D007267:Injections; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D020768:Middle Cerebral Artery / Q000473:pathology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology; D012849:Sinoatrial Node / Q000502:physiology; D017552:Solitary Nucleus / Q000502:physiology; D013373:Substance P / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D053583:Interleukin-1beta; D015850:Interleukin-6; D012503:Saponins; D013373:Substance P