New pharmacological agents for the treatment of gastroesophageal reflux disease.
Proton pump inhibitors (PPIs) are currently the most effective and most widely used agents for gastroesophageal reflux disease (GERD). Despite the efficacy of these agents in healing and symptom relief, a substantial proportion of patients require twice-daily therapy with PPIs, and break-through symptoms cause others to use over-the-counter antacids and histamine 2-receptor antagonists to supplement their PPI therapy. Major strategies that are being pursued include the development of agents that have a faster onset of action for on-demand therapy; have better control of acid secretion, resulting in improved healing in advanced grades of esophagitis and better symptom control; and agents that decrease transient lower esophageal sphincter relaxations (TLESRs), thereby reducing distal acid exposure and weakly acidic refluxate. A number of new pharmaceutical agents are currently undergoing clinical evaluation for the treatment of GERD. These include agents that reduce TLESRs, serotonergic agents/ prokinetics, long-acting PPIs, mucosal protectants, and antigastrin agents. One or more of these agents may be the future of GERD therapy.
Vakil
Nimish
N
University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001549:Benzamides / Q000494:pharmacology / Q000627:therapeutic use; D020117:Cisapride / Q000627:therapeutic use; D049630:Esophageal Sphincter, Lower / Q000187:drug effects; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D054328:Proton Pump Inhibitors / Q000008:administration & dosage; D011725:Pyridines / Q000627:therapeutic use; D011812:Quinuclidines / Q000494:pharmacology / Q000627:therapeutic use; D058828:Serotonin 5-HT4 Receptor Agonists
C514958:AZD0865; D000897:Anti-Ulcer Agents; D001549:Benzamides; D007093:Imidazoles; D054328:Proton Pump Inhibitors; D011725:Pyridines; D011812:Quinuclidines; D058828:Serotonin 5-HT4 Receptor Agonists; C517618:ATI 7505; D020117:Cisapride