title: The prevalence of Th17 cells in patients with gastric cancer.
abstract: Th17 cells have emerged as an important mediator in inflammatory and autoimmune diseases. However, recent studies suggest a potential impact of Th17 cells on tumor. The current study was designed to investigate the possible involvement of Th17 cells in gastric cancer. Compared with healthy volunteers, patients with gastric cancer had a higher proportion of Th17 cells in peripheral blood. Notably, the increased prevalence of Th17 cells was associated with clinical stage. In addition, increased populations of Th17 cells were present in tumor-draining lymph nodes with advanced disease. Furthermore, the mRNA expression levels of Th17-related factors (IL-17, IL-23p19, and RORC) in tumor tissues and the serum concentrations of IL-17 and IL-23 cytokines were significantly increased in patients with advanced gastric cancer. The results indicate that Th17 cells may contribute to gastric cancer pathogenesis.
authors.affiliation: Department of General Surgery, Changhai Hospital, The Second Military Medical University, No. 168, Changhai Road, Shanghai 200433, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Guanghua
authors.initials: G
authors.lastname: Rong
authors.forename: Huafeng
authors.initials: H
authors.lastname: Wei
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.forename: Jianwei
authors.initials: J
authors.lastname: Bi
authors.forename: Liye
authors.initials: L
authors.lastname: Ma
authors.forename: Xuchao
authors.initials: X
authors.lastname: Xue
authors.forename: Guo
authors.initials: G
authors.lastname: Wei
authors.forename: Xiaokang
authors.initials: X
authors.lastname: Liu
authors.forename: Guoen
authors.initials: G
authors.lastname: Fang
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D053760:Interleukin-23 Subunit p19 / Q000097:blood / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism; D013274:Stomach Neoplasms / Q000276:immunology* / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D020381:Interleukin-17; D053760:Interleukin-23 Subunit p19; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear