[Change of ACTH and cortisol in patients with obstructive sleep apnea hypopnea syndrome after the operation of uvulopalatopharyngoplasty].
OBJECTIVE
To explore the change of hypothalamus-pituitary-adrenal hormone in patients with Obstructive sleep apnea hypopnea syndrome (OSAHS) by observing the change of Corticotropin (ACTH) and cortisol after Uvulopalatopharyngoplasty (UPPP).


METHODS
OSAHS patients were monitored by polysomnography (PSG). The ACTH and cortisol levels in plasma were measured by radioimmunoassay before, during and after sleep in pre-operation and six months post-operation. Their correlation were analyzed.


RESULTS
The cortisol concentration [ (170.4+/-56.5) microg/L, (252.2+/-62.3) microg/L, (276.9+/-70.4) microg/L, (2859.0+/-63.2) microg/L, (395.1+/-85.2) microg/L before, during and after sleep] in the before UPPP group were significantly higher than those of the after UPPP group [(133.5+/-24.8) microg/L, (99.9+/-9.2) microg/L, (103.8+/-13.2) microg/L, (146.2+/-22.5) microg/L, (199.6+/-20.9) microg/L before, during and after sleep, respectively, all P <0. 05]; but there was no difference in corticotropin(ACTH). The average blood oxygen concentration was negatively correlated with average awareness duration (r = -0.713).


CONCLUSIONS
There are abnormal change of HPA axis in OSAHS patients, and the feedback regulation is disordered. These abnormalities are related to sleep awareness and hypoxia during sleep.
Liu
Yulin
Y
Department of Otolaryngology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. liuyulin_1982@126.com
Yao
Xianyi
X
Wang
Leqiu
L
Wu
Qiang
Q
Li
Yuchun
Y
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010159:Palate / Q000601:surgery; D010614:Pharynx / Q000601:surgery; D011184:Postoperative Period; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000601:surgery; D014609:Uvula / Q000601:surgery
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone