title: Early induction of moderate hypothermia suppresses systemic inflammatory cytokines and intracellular adhesion molecule-1 in rats with caerulein-induced pancreatitis and endotoxemia.
abstract: OBJECTIVE
  To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats.
  
  
  METHODS
  The effects of MH were compared in 4 groups, that is, sham group (38 degrees C), control group (38 degrees C), early MH group (32 degrees C on administration of lipopolysaccharide [LPS]), and delayed MH group (32 degrees C 1 hour after LPS). AP and endotoxemia were induced by intramuscular injection of caerulein and intraperitoneal injection of LPS.
  
  
  RESULTS
  Serum interleukin 6 (IL-6) in both MH groups was significantly lower than that in the control group at 3 hours. Serum interleukin 10 (IL-10) in the early MH group was significantly higher than those in the other 3 groups at 1 hour. IL-10/IL-6 ratios in both MH groups were significantly higher than that in the control group at 3 hours. Serum soluble intercellular adhesion molecule (sICAM-1) in both MH groups was significantly lower than that in the control group at 3 hours. Serum sICAM-1 in the early MH group was significantly lower than that in the delayed MH group. The tendency of pancreatic ICAM-1 was similar to that of serum sICAM-1.
  
  
  CONCLUSIONS
  Early induction of MH might be protective against pancreatic injury and systemic inflammation in AP and endotoxemia.
authors.affiliation: Department of Critical Care and Emergency Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan. fujiken-ygc@umin.ac.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Motoki
authors.initials: M
authors.lastname: Fujita
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Tsuruta
authors.forename: Ryo
authors.initials: R
authors.lastname: Tanaka
authors.forename: Hiromi
authors.initials: H
authors.lastname: Shinagawa
authors.forename: Tomonori
authors.initials: T
authors.lastname: Izumi
authors.forename: Shunji
authors.initials: S
authors.lastname: Kasaoka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Maekawa
mesh_terms: D000818:Animals; D002108:Ceruletide / Q000633:toxicity; D016207:Cytokines / Q000097:blood*; D019446:Endotoxemia / Q000097:blood* / Q000139:chemically induced / Q000628:therapy*; D007036:Hypothermia, Induced; D018836:Inflammation Mediators / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood* / Q000378:metabolism; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D010179:Pancreas / Q000378:metabolism; D010195:Pancreatitis / Q000097:blood* / Q000139:chemically induced / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D015850:Interleukin-6; D008070:Lipopolysaccharides; D018799:Intercellular Adhesion Molecule-1; D016753:Interleukin-10; D002108:Ceruletide