title: [Clinicopathologic analysis of spindle cell rhabdomyosarcoma: report of 8 cases].
abstract: OBJECTIVE
  To study the clinicopathological features of spindle cell rhabdomyosarcoma (SCRMS) in order to differentiate it from other myosarcomas.
  
  
  METHODS
  The clinical features, morphologic and immunohistochemical phenotypes of 8 SCRMSs were analyzed.
  
  
  RESULTS
  SCRMS cells were found to be arranged in a fascicular or storiform pattern, in which a number of enlarged plump or polygonal shaped rhabdomyoblasts containing abundant eosinophilic cytoplasm with eccentrically placed enlarged hyperchromatic nuclei were mixed. Immunohistochemical staining results showed that vimentin, MyoD1, desmin, actin, myoglobin were positive in tumor cells, but S-100, plap, AE1/AE3, CK, CD117 negative. The follow-up data showed that four cases had died of the recurrent disease, one still alive and the remain three patients lost follow-up.
  
  
  CONCLUSIONS
  Spindle cell rhabdomyosarcoma is a rare embryonal rhabdomyosarcoma which occurs in the childhood or adulthood with a poor prognosis, and is frequently presented as a painless mass most frequently involveing the head and neck or cervical area or para-testis site. A combination of MyoD1, desmin and myoglobin immunohistochemical staining is helpful in differential diagnosis.
authors.affiliation: Department of Pathology, Cancer Hospital (Institute), Chinese Academy of Medical Sciences, Beijing 100021, China. zhanghongtu1010@yahoo.com.cn
authors.forename: Hong-Tu
authors.initials: HT
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Qin
authors.initials: Q
authors.lastname: Su
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003131:Combined Modality Therapy; D003893:Desmin / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017570:MyoD Protein / Q000378:metabolism; D009211:Myoglobin / Q000378:metabolism; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D018233:Rhabdomyosarcoma, Embryonal / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D055815:Young Adult
chemical_list: D003893:Desmin; D017570:MyoD Protein; C057363:MyoD1 myogenic differentiation protein; D009211:Myoglobin