title: 3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurements.
abstract: A combined experimental/numerical study was performed to calculate the 3D octahedral shear strain map in a mouse tibia loaded axially. This study is motivated by the fact that the bone remodelling analysis, in this in vivo mouse model should be performed at the zone of highest mechanical stimulus to maximise the measured effects. Accordingly, it is proposed that quantification of bone remodelling should be performed at the tibial crest and at the distal diaphysis. The numerical model could also be used to furnish a more subtle analysis as a precise correlation between local strain and local biological response can be obtained with the experimentally validated numerical model.
authors.affiliation: Laboratory of Biomechanical Orthopedics EPFL-HOSR, Institute of Translational Biomechanics, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Stadelmann
authors.forename: Jean
authors.initials: J
authors.lastname: Hocke
authors.forename: Jensen
authors.initials: J
authors.lastname: Verhelle
authors.forename: Vincent
authors.initials: V
authors.lastname: Forster
authors.forename: Francesco
authors.initials: F
authors.lastname: Merlini
authors.forename: Alexandre
authors.initials: A
authors.lastname: Terrier
authors.forename: Dominique P
authors.initials: DP
authors.lastname: Pioletti
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D019245:Compressive Strength / Q000502:physiology; D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D033081:Shear Strength; D013314:Stress, Mechanical; D013977:Tibia / Q000502:physiology*; D016474:Weight-Bearing / Q000502:physiology*