[The study of Rougan Jiedu formula anti-liver cancer in vivtro].
OBJECTIVE
To observe the effects of the anti-liver cancer pharmacodynamic action of the Rougan Jiedu formula through the experiments of inhibiting cell proliferation of the tumour cell in vitro.


METHODS
The pharmaceutic serum of Rougan Jiedu formula was prepared and the influence of the pharmaceutic serum of Rougan Jiedu formula to the cell proliferation of hepatoma carcinoma cell HepG2, SMMC-7721 was observed.


RESULTS
Rougan Jiedu formula blood-serum could remarkably inhibit the proliferation of the cell line of HepG2, SMMC-7721, the maximum inhibition ratio to the HepG2 was 69.73%, the maximum inhibition ratio to the SMMC-7721 was 69.73%. Compared to the blank group and PBS group, the difference was significant (P < 0.01); the effects of high dose, compared to the 5-FU group, the difference had no significance (P > 0.05). The inhibition ratio of Chinese medicine groups followed the increase of the doses.


CONCLUSIONS
The Rougan Jiedu formula has good effects on inhibiting the proliferation of the tumour cell in vitro.
Wu
Chen-Jiao
CJ
The Worker' s Hospital of South Oil, Zhanjiang 524000, China.
Li
Hong
H
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005472:Fluorouracil / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D011817:Rabbits; D011897:Random Allocation
D000972:Antineoplastic Agents, Phytogenic; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005472:Fluorouracil