title: Determination of log D via automated microfluidic liquid-liquid extraction.
abstract: A method for log D (pH 7.4) measurement was developed using microfluidic liquid-liquid extraction. Values were determined for 26 compounds and compared to results obtained via shake-flask methods. Excellent correlation between the values obtained via both methods was achieved (R(2) = 0.994). The developed methodology is amenable to automation, enabling high-throughput determination of large compound collections.
authors.affiliation: Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, USA.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Alimuddin
authors.forename: Daniel
authors.initials: D
authors.lastname: Grant
authors.forename: Daryl
authors.initials: D
authors.lastname: Bulloch
authors.forename: Noelle
authors.initials: N
authors.lastname: Lee
authors.forename: Martin
authors.initials: M
authors.lastname: Peacock
authors.forename: Russell
authors.initials: R
authors.lastname: Dahl
mesh_terms: D001331:Automation; D001702:Biopharmaceutics / Q000379:methods*; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D010599:Pharmacokinetics