title: Targeted delivery of magnetic aerosol droplets to the lung.
abstract: The inhalation of medical aerosols is widely used for the treatment of lung disorders such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, respiratory infection and, more recently, lung cancer. Targeted aerosol delivery to the affected lung tissue may improve therapeutic efficiency and minimize unwanted side effects. Despite enormous progress in optimizing aerosol delivery to the lung, targeted aerosol delivery to specific lung regions other than the airways or the lung periphery has not been adequately achieved to date. Here, we show theoretically by computer-aided simulation, and for the first time experimentally in mice, that targeted aerosol delivery to the lung can be achieved with aerosol droplets comprising superparamagnetic iron oxide nanoparticles--so-called nanomagnetosols--in combination with a target-directed magnetic gradient field. We suggest that nanomagnetosols may be useful for treating localized lung disease, by targeting foci of bacterial infection or tumour nodules.
authors.forename: Petra
authors.initials: P
authors.lastname: Dames
authors.forename: Bernhard
authors.initials: B
authors.lastname: Gleich
authors.forename: Andreas
authors.initials: A
authors.lastname: Flemmer
authors.forename: Kerstin
authors.initials: K
authors.lastname: Hajek
authors.forename: Nicole
authors.initials: N
authors.lastname: Seidl
authors.forename: Frank
authors.initials: F
authors.lastname: Wiekhorst
authors.forename: Dietmar
authors.initials: D
authors.lastname: Eberbeck
authors.forename: Iris
authors.initials: I
authors.lastname: Bittmann
authors.forename: Christian
authors.initials: C
authors.lastname: Bergemann
authors.forename: Thomas
authors.initials: T
authors.lastname: Weyh
authors.forename: Lutz
authors.initials: L
authors.lastname: Trahms
authors.forename: Joseph
authors.initials: J
authors.lastname: Rosenecker
authors.forename: Carsten
authors.initials: C
authors.lastname: Rudolph
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D008168:Lung / Q000378:metabolism*; D008280:Magnetics / Q000627:therapeutic use; D050997:Nanomedicine / Q000379:methods* / Q000639:trends*; D053758:Nanoparticles / Q000627:therapeutic use / Q000648:ultrastructure; D051381:Rats
chemical_list: D000336:Aerosols