title: Preliminary study on crystal dissolution activity of Rotula aquatica, Commiphora wightii and Boerhaavia diffusa extracts.
abstract: Several Ayurvedic plants are known to have activity against diverse urinary crystals. The traditional knowledge of Ayurveda, collective clinical experience in arthritis and the earlier experimental studies on urinary crystals led to the selection of three plants, viz. Rotula aquatica, Commiphora wightii Bhandari syn. C.mukul. and Boerhaavia diffusa for screening anticrystal activity against basic calcium phosphate (BCP), calcium pyrophosphate (CPPD) and monosodium urate monohydrate (MSUM). The effects of each plant were assayed on microcrystals in 24-well microplates in vitro. Our results show that the aqueous extracts of only R. aquatica and C. wightii have shown crystal dissolving activity against MSUM.
authors.affiliation: Bharatiya Vidya Bhavan's Swami Prakashananda Ayurveda Research Centre, 13th North-South Road, Juhu, Mumbai-400 049, India. ashuraut@gmail.com
authors.forename: Ashwinikumar A
authors.initials: AA
authors.lastname: Raut
authors.forename: Sudha
authors.initials: S
authors.lastname: Sunder
authors.forename: Subrata
authors.initials: S
authors.lastname: Sarkar
authors.forename: Nancy S
authors.initials: NS
authors.lastname: Pandita
authors.forename: Ashok D B
authors.initials: AD
authors.lastname: Vaidya
mesh_terms: D028082:Boraginaceae / Q000737:chemistry*; D002130:Calcium Phosphates / Q000378:metabolism; D002131:Calcium Pyrophosphate / Q000378:metabolism; D029744:Commiphora / Q000737:chemistry*; D003460:Crystallization; D004305:Dose-Response Relationship, Drug; D008515:Medicine, Ayurvedic; D039281:Nyctaginaceae / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D012116:Resins, Plant; D014527:Uric Acid / Q000378:metabolism*; D052878:Urolithiasis / Q000188:drug therapy*
chemical_list: D002130:Calcium Phosphates; D010936:Plant Extracts; D012116:Resins, Plant; D014527:Uric Acid; C020243:calcium phosphate; D002131:Calcium Pyrophosphate