Epidural adhesiolysis complicated by cefazolin-induced status epilepticus: two cases.
Cefazolin is a strong epileptogenic agent. We describe two patients presenting with status epilepticus, apparently caused by intrathecal leakage of cefazolin via incidental dural puncture during spinal epidural adhesiolysis. Our cases suggest that the local use of antibiotics, particularly cefazolin, in the form of a mixture with contrast medium during a spinal procedure is not advisable, because of the possible incidental intrathecal leakage and the high convulsive potential of the antibiotics.
Choi
Jeong-Yoon
JY
Department of Neurology, Korea University Medical Center, Korea University College of Medicine, Seoul, Republic of Korea.
Seok
Hung Youl
HY
Lee
Sang-Heon
SH
Kim
Byung-Jo
BJ
Park
Kun-Woo
KW
Jung
Ki-Young
KY
D000368:Aged; D000767:Anesthesia, Epidural / Q000009:adverse effects / Q000379:methods*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D002437:Cefazolin / Q000008:administration & dosage / Q000009:adverse effects*; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007268:Injections, Epidural; D007472:Iohexol / Q000008:administration & dosage; D013129:Spinal Puncture / Q000009:adverse effects / Q000379:methods; D013226:Status Epilepticus / Q000139:chemically induced*
D000900:Anti-Bacterial Agents; D003287:Contrast Media; D007472:Iohexol; D002437:Cefazolin