Asymmetric addition of dimethylzinc to alpha-ketoesters catalyzed by (-)-MITH.
This investigation describes the catalytic asymmetric addition of dimethylzinc to alpha-ketoesters in the presence of (-)-MITH ( 5) and triethyl borate as an additive to give the corresponding chiral alpha-hydroxy esters with good yields and high enantioselectivities.
Wu
Hsyueh-Liang
HL
Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan 30013, Republic of China.
Wu
Ping-Yu
PY
Shen
Ying-Ying
YY
Uang
Biing-Jiun
BJ
D000447:Aldehydes / Q000737:chemistry; D001892:Camphanes / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D009025:Morpholines / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry
D000447:Aldehydes; D001892:Camphanes; D004952:Esters; D007659:Ketones; D008024:Ligands; D009025:Morpholines; D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; C511262:dimethylzinc