title: Global patterns of variation in allele and haplotype frequencies and linkage disequilibrium across the CYP2E1 gene.
abstract: Cytochrome P450 2E1, gene symbol CYP2E1, is one of a family of enzymes with a central role in activating and detoxifying xenobiotics and endogenous compounds. Genetic variation at this gene has been reported in different human populations, and some association studies have reported increased risk for cancers and other diseases. To the best of our knowledge, multi-single-nucleotide polymorphism haplotypes and linkage disequilibrium (LD) have not been systematically studied for CYP2E1 in multiple populations. Haplotypes can greatly increase the power both to identify patterns of genetic variation relevant for gene expression as well as to detect disease-related susceptibility mutations. We present frequency and LD data and analyses for 11 polymorphisms and their haplotypes that we have studied on over 2600 individuals from 50 human population samples representing the major geographical regions of the world. The diverse patterns of haplotype variation found in the different populations we have studied show that ethnicity may be an important variable helping to explain inconsistencies that have been reported by association studies. More studies clearly are needed of the variants we have studied, especially those in the 5' region, such as the variable number of tandem repeats, as well as studies of additional polymorphisms known for this gene to establish evidence relating any systematic differences in gene expression that exist to the haplotypes at this gene.
authors.affiliation: Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: M-Y
authors.initials: MY
authors.lastname: Lee
authors.forename: N
authors.initials: N
authors.lastname: Mukherjee
authors.forename: A J
authors.initials: AJ
authors.lastname: Pakstis
authors.forename: S
authors.initials: S
authors.lastname: Khaliq
authors.forename: A
authors.initials: A
authors.lastname: Mohyuddin
authors.forename: S Q
authors.initials: SQ
authors.lastname: Mehdi
authors.forename: W C
authors.initials: WC
authors.lastname: Speed
authors.forename: J R
authors.initials: JR
authors.lastname: Kidd
authors.forename: K K
authors.initials: KK
authors.lastname: Kidd
mesh_terms: D000483:Alleles; D005075:Biological Evolution; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D040961:Genetic Drift; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium
chemical_list: D019392:Cytochrome P-450 CYP2E1