Synthesis and biological evaluation of C-12' substituted vinflunine derivatives.
A series of novel C-12' substituted vinflunine derivatives have been synthesized. Several compounds in this series possess comparable in vitro cytotoxic potency against A549 cell lines.
Lei
Xin Sheng
XS
Shanghai Hengrui Pharmaceuticals Co., Ltd., 279 Wenjing Road, Shanghai 200245, China.
Yu
Xiang Da
XD
Yin
Long
L
Liu
Zhen Hong
ZH
Tang
Peng Cho
PC
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008870:Microtubules / Q000737:chemistry; D008956:Models, Chemical; D008968:Molecular Conformation; D019810:Sodium Azide / Q000494:pharmacology; D014404:Tubulin / Q000737:chemistry; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D014404:Tubulin; C111217:vinflunine; D014747:Vinblastine; D019810:Sodium Azide