A study of the serum carotenoids of eight cases of hypercarotenemia in Sri Lanka.
Over-consumption of absorbable carotenoids causes hypercarotenemia. Although hypercarotenemia is detected in Sri Lanka, a detailed study on this condition has not been carried out previously. Two millilitres of venous blood was drawn from hypercarotenemic patients (n=8) and examined by high-performance liquid chromatography for carotenoids and vitamin A. A common high-performance liquid chromatographic pattern in serum was shown by six of the cases with beta-carotene (9.9-35.7 microg/dl), beta-cryptoxanthin and monohydroxy metabolites collectively (5.3-48.5 microg/dl), and six to eight metabolites of dihydroxy, trihydroxy and polyhydroxy metabolites (22.5-282.1 microg/dl). Vitamin A levels were within the normal range (32-61 microg/dl). However, two cases identified were abnormal. The first of these showed low beta-carotene (3.5 microg/dl) and no beta-cryptoxanthin and monohydroxy metabolites, but normal dihydroxy, trihydroxy and polyhydroxy metabolites (128.2 microg/dl). However, the vitamin A level was high (75.2 microg/dl). The other case showed high beta-carotene (212.3 microg/dl) and beta-cryptoxanthin (49.3 microg/dl) but no normal monohydroxy, dihydroxy, trihydroxy and polyhydroxy metabolites. Instead there was an atypical metabolite (343.9 microg/dl). According to the present study, excessive intake of boiled, homogenized carrot and ripe papaw is the main causative factor for hypercarotenemia. Over-consumption of carotenoids-rich plant foods may be complicated in the case of individuals having defects of either the control of the 15,15'-dioxygenase activity or metabolism of carotenoids.
Priyadarshani
A M B
AM
Department of Biochemistry, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka. buddhiathapaththu@yahoo.com
Lamabadusuriya
Sanath P
SP
Seneviratne
T R S
TR
Jansz
E R
ER
Peiris
H
H
D000975:Antioxidants / Q000633:toxicity*; D002338:Carotenoids / Q000097:blood*; D015362:Child Nutrition Disorders / Q000097:blood*; D002675:Child, Preschool; D065366:Cryptoxanthins; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D013188:Sri Lanka; D014801:Vitamin A / Q000097:blood; D024341:Xanthophylls / Q000097:blood; D019207:beta Carotene / Q000097:blood*
D000975:Antioxidants; D065366:Cryptoxanthins; D024341:Xanthophylls; D019207:beta Carotene; D014801:Vitamin A; D002338:Carotenoids