Broad spectrum bioactive sunscreens.
The development of sunscreens containing reduced concentration of chemical UV filters, even though, possessing broad spectrum effectiveness with the use of natural raw materials that improve and infer UV absorption is of great interest. Due to the structural similarities between polyphenolic compounds and organic UV filters, they might exert photoprotection activity. The objective of the present research work was to develop bioactive sunscreen delivery systems containing rutin, Passiflora incarnata L. and Plantago lanceolata extracts associated or not with organic and inorganic UV filters. UV transmission of the sunscreen delivery system films was performed by using diffuse transmittance measurements coupling to an integrating sphere. In vitro photoprotection efficacy was evaluated according to the following parameters: estimated sun protection factor (SPF); Boot's Star Rating category; UVA/UVB ratio; and critical wavelength (lambda(c)). Sunscreen delivery systems obtained SPF values ranging from 0.972+/-0.004 to 28.064+/-2.429 and bioactive compounds interacted with the UV filters positive and negatively. This behavior may be attributed to: the composition of the delivery system; the presence of inorganic UV filter and quantitative composition of the organic UV filters; and the phytochemical composition of the P. incarnata L. and P. lanceolata extracts. Among all associations of bioactive compounds and UV filters, we found that the broad spectrum sunscreen was accomplished when 1.68% (w/w) P. incarnata L. dry extract was in the presence of 7.0% (w/w) ethylhexyl methoxycinnamate, 2.0% (w/w) benzophenone-3 and 2.0% (w/w) TiO(2). It was demonstrated that this association generated estimated SPF of 20.072+/-0.906 and it has improved the protective defense against UVA radiation accompanying augmentation of the UVA/UVB ratio from 0.49 to 0.52 and lambda(c) from 364 to 368.6nm.
Velasco
Maria Valéria Robles
MV
Laboratory of Cosmetology, Department of Pharmacy, School of Pharmaceutical Sciences of University of São Paulo, São Paulo, SP, Brazil.
Sarruf
Fernanda Daud
FD
Salgado-Santos
Idalina Maria Nunes
IM
Haroutiounian-Filho
Carlos Alberto
CA
Kaneko
Telma Mary
TM
Baby
André Rolim
AR
D001577:Benzophenones / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D002934:Cinnamates / Q000737:chemistry; D003094:Collagen / Q000737:chemistry; D016503:Drug Delivery Systems; D029598:Passiflora; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry*; D010943:Plantago; D012431:Rutin / Q000008:administration & dosage / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013473:Sunscreening Agents / Q000008:administration & dosage / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry; D014466:Ultraviolet Rays
D001577:Benzophenones; D002934:Cinnamates; D010936:Plant Extracts; D013473:Sunscreening Agents; C516303:ethylhexyl methoxycinnamate; C009495:titanium dioxide; D012431:Rutin; D003094:Collagen; C005290:oxybenzone; D014025:Titanium