Association of adiponectin with procollagen type I carboxyterminal propeptide in non-diabetic essential hypertension.
OBJECTIVE
The serum concentration of procollagen type I carboxyterminal propeptide (PICP) is a good marker for collagen deposition in hypertension. Increased collagen deposition was associated with myocardial fibrosis and increased arterial stiffness. A decreased adiponectin level is associated with increased atherosclerosis. The role of adiponectin and its relation to PICP in essential hypertension have rarely been studied before.


METHODS
We recruited 188 non-diabetic uncomplicated hypertensive patients (mean age: 41+/-7 years; 128 men). No patient had vascular complications or renal or liver diseases. Overnight fasting blood samples were collected to assess patient lipid profiles, blood sugar, insulin, high-sensitivity C-reactive protein (hsCRP), PICP and adiponectin. Carotid to radial pulse wave velocity (PWV) measured using tonometry was used as an index of arterial stiffness.


RESULTS
Adiponectin (r = -0.216, p = 0.003) and male gender (p<0.001) were independent determinants of PICP. Diastolic blood pressure (r = 0.422, p<0.001) and current smoking (p = 0.005) were independent determinants of PWV. PWV was significantly correlated with PICP (r = 0.156, p = 0.034). Adiponectin was significantly correlated with triglyceride (r = -0.276, p<0.001), high-density lipoprotein (r = 0.262, p<0.001), the homeostasis model assessment (HOMA) index (r = -0.220, p = 0.002), hsCRP (r = -0.207, p = 0.004) and the body mass index (BMI) (r = -0.202, p = 0.005). After compensation with possible confounding factors, adiponectin was still significantly correlated with PICP (beta = -0.196, p = 0.006).


CONCLUSIONS
Serum adiponectin may be a marker for metabolic syndrome in essential hypertension. Adiponectin was significantly negatively correlated with PICP. Metabolic syndrome probably plays an important role in increased collagen synthesis and arterial stiffness through the effects of decreased adiponectin in non-diabetic essential hypertension.
Tsai
Wei-Chuan
WC
Department of Internal Medicine, National Cheng Kung University Hospital Dou-Liou Branch, Dou-Liou, Taiwan. wctsai@ksmail.seed.net.tw
Lin
Chih-Chan
CC
Chen
Ju-Yi
JY
Huang
Yao-Yi
YY
Lee
Cheng-Han
CH
Li
Wei-Ting
WT
Weng
Chiung-Mei
CM
Chen
Jyh-Hong
JH
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001158:Arteries / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood*; D001783:Blood Flow Velocity; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D003971:Diastole / Q000187:drug effects; D004548:Elasticity; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010045:Outpatients; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D011673:Pulsatile Flow; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood
D052242:Adiponectin; D000959:Antihypertensive Agents; D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D010446:Peptide Fragments; D011347:Procollagen; D014280:Triglycerides; C042813:procollagen type I carboxy terminal peptide; D002097:C-Reactive Protein