Tandem multi-step synthesis of C-carboxyazlactones promoted by N-heterocyclic carbenes.
Cascade reaction sequences incorporating N-heterocyclic carbene-based organocatalysis have been developed that allow the direct preparation of a range of (+/-)-4-phenoxycarbonylazlactones in good isolated yields (66-84%) from the corresponding N-p-anisoyl amino acids.
Campbell
Craig D
CD
EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, UK KY16 9ST.
Duguet
Nicolas
N
Gallagher
Katherine A
KA
Thomson
Jennifer E
JE
Lindsay
Anita G
AG
O'Donoghue
Annmarie C
AC
Smith
Andrew D
AD