[Effect of baclofen on characteristics of the cellular immune response].
It has been established that GABA-B receptor agonist baclofen restores the cellular parts (the delay-type hypersensitivity reaction index, thymus weight, and thymocyte number) of immunogenesis under the experimental suppression conditions. This is probably caused both by the direct influence of baclofen on the receptors of immunocompetent cells and by the normalization of the nervous regulation of the immune response.
Tiurenkov
I N
IN
Samotrueva
M A
MA
Ovcharova
A N
AN
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013950:Thymus Gland / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects
D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D001418:Baclofen