title: Standard whipple's operation versus pylorus preserving pancreaticoduodenectomy: a randomized controlled trial study.
abstract: OBJECTIVE
  A single-institution randomized controlled trial was conducted to compare the results of standard whipple operation (SW) with those of pylorus-preserving pancreaticoduodenectomy (PPPD).
  
  
  METHODS
  Between January 2000 and December 2004, 27 patients with pancreatic or periampullary adenocarcinoma were enrolled into the study. All patients were randomly allocated to either a SW or a PPPD resection. Patients' characteristics, postoperative mortality and morbidity, and survival up to two years were compared.
  
  
  RESULTS
  There were no significant differences in baseline characteristics between the two groups of patients. There were also no significant differences in blood loss and operative time. Delayed gastric emptying (DGE) occurred more frequently in the PPPD group, but other operative complications, hospital mortality, and the length of hospital stay were similar for the two groups. There were no significant survival differences at two years after operation.
  
  
  CONCLUSIONS
  SW and PPPD were comparable in terms of operation time, blood loss, operative mortality and morbidity, and survival. Although the incidence of DGE was higher in the PPPD group, the hospital stay was similar for both groups. Both surgical procedures were equally effective for the treatment of pancreatic and periampullary carcinoma.
authors.affiliation: Department of Surgery, Suratthani Hospital, Suratthani, Thailand. surg8@hotmail.com
authors.forename: Chatchai
authors.initials: C
authors.lastname: Srinarmwong
authors.forename: Prakob
authors.initials: P
authors.lastname: Luechakiettisak
authors.forename: Wasan
authors.initials: W
authors.lastname: Prasitvilai
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000368:Aged; D014670:Ampulla of Vater / Q000601:surgery*; D005260:Female; D005746:Gastric Emptying; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000379:methods* / Q000401:mortality; D019990:Perioperative Care; D011183:Postoperative Complications; D011184:Postoperative Period; D011708:Pylorus / Q000601:surgery*; D013534:Survival; D013997:Time Factors; D016896:Treatment Outcome