title: Differences in cardiac microcirculatory wave patterns between the proximal left mainstem and proximal right coronary artery.
abstract: Despite having almost identical origins and similar perfusion pressures, the flow-velocity waveforms in the left and right coronary arteries are strikingly different. We hypothesized that pressure differences originating from the distal (microcirculatory) bed would account for the differences in the flow-velocity waveform. We used wave intensity analysis to separate and quantify proximal- and distal-originating pressures to study the differences in velocity waveforms. In 20 subjects with unobstructed coronary arteries, sensor-tipped intra-arterial wires were used to measure simultaneous pressure and Doppler velocity in the proximal left main stem (LMS) and proximal right coronary artery (RCA). Proximal- and distal-originating waves were separated using wave intensity analysis, and differences in waves were examined in relation to structural and anatomic differences between the two arteries. Diastolic flow velocity was lower in the RCA than in the LMS (35.1 +/- 21.4 vs. 56.4 +/- 32.5 cm/s, P < 0.002), and, consequently, the diastolic-to-systolic ratio of peak flow velocity in the RCA was significantly less than in the LMS (1.00 +/- 0.32 vs. 1.79 +/- 0.48, P < 0.001). This was due to a lower distal-originating suction wave (8.2 +/- 6.6 x 10(3) vs. 16.0 +/- 12.2 x 10(3) W.m(-2).s(-1), P < 0.01). The suction wave in the LMS correlated positively with left ventricular pressure (r = 0.6, P < 0.01) and in the RCA with estimated right ventricular systolic pressure (r = 0.7, P = 0.05) but not with the respective diameter in these arteries. In contrast to the LMS, where coronary flow velocity was predominantly diastolic, in the proximal RCA coronary flow velocity was similar in systole and diastole. This difference was due to a smaller distal-originating suction wave in the RCA, which can be explained by differences in elastance and pressure generated between right and left ventricles.
authors.affiliation: International Centre for Circulatory Health, Imperial College Healthcare National Health Service Trust, St. Mary's Hospital, 59-61 N. Wharf Rd., London W2 1LA, UK. n.hadjiloizou@imperial.ac.uk
authors.forename: Nearchos
authors.initials: N
authors.lastname: Hadjiloizou
authors.forename: Justin E
authors.initials: JE
authors.lastname: Davies
authors.forename: Iqbal S
authors.initials: IS
authors.lastname: Malik
authors.forename: Jazmin
authors.initials: J
authors.lastname: Aguado-Sierra
authors.forename: Keith
authors.initials: K
authors.lastname: Willson
authors.forename: Rodney A
authors.initials: RA
authors.lastname: Foale
authors.forename: Kim H
authors.initials: KH
authors.lastname: Parker
authors.forename: Alun D
authors.initials: AD
authors.lastname: Hughes
authors.forename: Darrel P
authors.initials: DP
authors.lastname: Francis
authors.forename: Jamil
authors.initials: J
authors.lastname: Mayet
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002196:Capillaries / Q000502:physiology; D006328:Cardiac Catheterization; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000502:physiology*; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results