Outcomes of kidney transplantation from older living donors to older recipients.
BACKGROUND
More than half the newly wait-listed patients for kidney transplantation in 2005 were older than 50 years, and 13% were older than 65 years. As waiting times for a deceased donor kidney increase, these older candidates are disadvantaged by rapidly deteriorating health, often resulting in death or removal from the wait list before transplantation.


METHODS
An observational cohort study was conducted using data from the Organ Procurement Transplant Network/United Network for Organ Sharing.


METHODS
All adult kidney-only transplantations performed in recipients 60 years and older from 1996 to 2005 were included.


METHODS
The recipient cohort was stratified into 4 groups based on donor source: older living donor (OLD: living donor age > 55 years), younger living donor (YLD: living donor age </= 55 years), standard criteria deceased donor (SCD), and expanded criteria deceased donor (ECD).


METHODS
Early posttransplantation outcomes, graft survival, patient survival, renal function 1 year posttransplantation, and relative risk of graft loss and patient death were compared.


RESULTS
Of 23,754 kidney transplantations performed in recipients 60 years and older, 7,006 were living donor transplantations (1,133 were > 55 years [OLD] and 5,873 were <or= 55 years [YLD]), 12,197 from SCDs, and 4,551 from ECDs. Early posttransplantation outcomes were best in YLD transplantations, followed by SCD and OLD transplantations. OLD transplantations were associated with inferior 3-year graft survival rates (85.7%), but similar 3-year patient survival rates (88.4%) compared with YLD (3-year graft survival, 83.4%; patient survival, 87.4%) and had superior graft survival compared with all deceased donor options. Compared with OLD transplantations, ECD transplantations were associated with a greater risk of graft loss (hazard ratio, 2.36; 95% confidence interval, 1.18 to 4.74).


CONCLUSIONS
Observational retrospective studies using registry data are subject to inherent limitations, including the possibility of selection bias.


CONCLUSIONS
With superior graft and patient survival in recipients of transplants from OLDs compared with SCDs and ECDs, OLDs may be an important option for elderly transplantation candidates and should be considered for older patients with a willing and suitable older donor.
Gill
Jagbir
J
Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. jsgill2@shaw.ca
Bunnapradist
Suphamai
S
Danovitch
Gabriel M
GM
Gjertson
David
D
Gill
John S
JS
Cecka
Michael
M
D000208:Acute Disease; D000368:Aged; D000375:Aging; D015331:Cohort Studies; D051799:Delayed Graft Function / Q000453:epidemiology; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000503:physiopathology; D016030:Kidney Transplantation / Q000401:mortality; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011183:Postoperative Complications / Q000453:epidemiology; D011184:Postoperative Period; D016016:Proportional Hazards Models; D051437:Renal Insufficiency / Q000453:epidemiology; D016019:Survival Analysis; D013997:Time Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome