Natural inhibitors of DNA topoisomerase I with cytotoxicities.
DNA Topoisomerase I can cause DNA breaks and play a key role during cell proliferation and differentiation. It is an important target for anticancer agents. While screening for anticancer compounds, seven natural compounds, 1-7, showed potent cytotoxicities against a panel of ten cancer cell lines. Moreover, an inhibition assay demonstrated that they are also DNA topoisomerase I inhibitors, in which inhibitors 1-5 are new ones.
Han
Hong-Jin
HJ
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China.
Tan
Ning-Hua
NH
Zeng
Guang-Zhi
GZ
Fan
Jun-Ting
JT
Huang
Huo-Qiang
HQ
Ji
Chang-Jiu
CJ
Jia
Rui-Rui
RR
Zhao
Qin-Shi
QS
Zhang
Ying-Jun
YJ
Hao
Xiao-Jiang
XJ
Wang
Li-Qin
LQ
D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D059004:Topoisomerase I Inhibitors
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D059004:Topoisomerase I Inhibitors