title: Antimicrobial resistance in Shigella species isolated in Dakar, Senegal (2004-2006).
abstract: From May 2004 to October 2006, a prospective study was carried out in Dakar, Senegal, to update information about the antimicrobial susceptibility of Shigella spp. isolated from stool specimens. Among the 165 non-duplicate strains collected, 81 (49%) were identified as Shigella flexneri, 75 (45%) as Shigella sonnei, 5 (3%) as Shigella boydii, and 4 (2%) as Shigella dysenteriae. Disk diffusion testing revealed that the majority of isolates were resistant to sulphonamides, trimethoprim-sulfamethoxazole, streptomycin, and tetracycline (respective overall resistance rates: 90, 90, 96, and 94%). More than half of the S. flexneri isolates were resistant to amoxicillin, amoxicillin-clavulanic acid, and chloramphenicol (respective resistance rates: 59, 58, and 52%), and almost all of the S. sonnei isolates were susceptible to these antimicrobials (respective resistance rates: 4, 1, and 4%). Only one isolate (belonging to the species S. sonnei) was resistant to nalidixic acid and displayed reduced susceptibility to ciprofloxacin.
authors.affiliation: Laboratoire de Biologie Medicale, Institut Pasteur, Dakar, Senegal. sire@pasteur.sn.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Sire
authors.forename: Edgard Adam
authors.initials: EA
authors.lastname: Macondo
authors.forename: Jean-David
authors.initials: JD
authors.lastname: Perrier-Gros-Claude
authors.forename: Tidiane
authors.initials: T
authors.lastname: Siby
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Bahsoun
authors.forename: Abdoulaye
authors.initials: A
authors.lastname: Seck
authors.forename: Benoit
authors.initials: B
authors.lastname: Garin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D052978:Disk Diffusion Antimicrobial Tests; D024881:Drug Resistance, Bacterial; D004405:Dysentery, Bacillary / Q000453:epidemiology / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D006801:Humans; D007223:Infant; D008875:Middle Aged; D012675:Senegal / Q000453:epidemiology; D012760:Shigella / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification; D012761:Shigella boydii / Q000187:drug effects / Q000302:isolation & purification; D012762:Shigella dysenteriae / Q000187:drug effects / Q000302:isolation & purification; D012763:Shigella flexneri / Q000187:drug effects / Q000302:isolation & purification; D012764:Shigella sonnei / Q000187:drug effects / Q000302:isolation & purification; D013045:Species Specificity
chemical_list: D000900:Anti-Bacterial Agents