Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis.
Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured cisplatin-mediated apoptosis and VEGF-mediated angiogenesis. The results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis, and it reveals calpain 6 as a novel therapeutic target for certain types of cancers.
Rho
Seung Bae
SB
Research Institute, National Cancer Center, 809, Madu 1-dong, Ilsan-gu, Goyang-si, Gyeonggi-do 411-769, Republic of Korea.
Byun
Hyun-Jung
HJ
Park
Sang-Yoon
SY
Chun
Taehoon
T
D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001483:Base Sequence; D015153:Blotting, Western; D002154:Calpain / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D002945:Cisplatin / Q000494:pharmacology; D003001:Cloning, Molecular; D017931:DNA Primers; D018076:DNA, Complementary; D005260:Female; D006367:HeLa Cells; D006801:Humans; D009389:Neovascularization, Pathologic; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000970:Antineoplastic Agents; D017931:DNA Primers; D018076:DNA, Complementary; D002154:Calpain; D002945:Cisplatin