title: Reduction in albuminuria translates to reduction in cardiovascular events in hypertensive patients with left ventricular hypertrophy and diabetes.
abstract: In type 2 diabetes the degree of albuminuria is strongly related to progression of diabetic renal disease, as well as to the risk for cardiovascular complications. If normoalbuminuria is maintained, the risk of diabetic nephropathy is very low. In individuals with microalbuminuria, the rate of decline in glomerular filtration rate is closely related to the degree of albuminuria, and regression to normoalbuminuria slows down the rate of decline in renal function. Data from the LIFE-diabetes subgroup showed that levels of albuminuria well below what is usually defined as microalbuminuria, strongly predicted risk for cardiovascular complications. This indicates that when albuminuria is used as a risk predictor for cardiovascular events, so called normal values should be redefined. Traditional values for normo-micro-macroalbuminuria are primarily defined as predictors for the risk of development of diabetic nephropathy. In the LIFE-diabetes subgroup we found that reduction in albuminuria was more pronounced in losartan-based as compared with atenolol-based treatment. The benefit in favor of losartan was partly related to its major influence on albuminuria. Individuals with the highest baseline values of albuminuria had the greatest benefit in terms of reduction in cardiovascular morbidity and mortality on losartan as compared with atenolol. The level of albuminuria during treatment was closely related to the risk for cardiovascular events. We conclude that tiny amounts of albuminuria, well below traditional levels for microalbuminuria, predict cardiovascular morbidity and mortality. Reduction in albuminuria during treatment translates to reduction in cardiovascular events. Monitoring of albuminuria should be an integrated part of management of hypertension in diabetic as well as nondiabetic patients.
authors.affiliation: Department of Cardiology, Holbaek Hospital, Holbaek - Denmark. hib@regionsjaelland.dk
authors.forename: H
authors.initials: H
authors.lastname: Ibsen
authors.forename: M H
authors.initials: MH
authors.lastname: Olsen
authors.forename: K
authors.initials: K
authors.lastname: Wachtell
authors.forename: K
authors.initials: K
authors.lastname: Borch-Johnsen
authors.forename: L H
authors.initials: LH
authors.lastname: Lindholm
authors.forename: C E
authors.initials: CE
authors.lastname: Mogensen
mesh_terms: D000419:Albuminuria / Q000150:complications / Q000503:physiopathology / Q000652:urine*; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D003404:Creatinine / Q000652:urine*; D003718:Denmark / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D017379:Hypertrophy, Left Ventricular / Q000150:complications* / Q000378:metabolism; D019808:Losartan / Q000627:therapeutic use; D009017:Morbidity / Q000639:trends; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000209:etiology; D011379:Prognosis; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology; D015996:Survival Rate / Q000639:trends; D013997:Time Factors
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D003404:Creatinine; D019808:Losartan