title: Pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis sp.
abstract: A novel cyclic peptide antibiotic, pargamicin A was isolated from the culture broth of an actinomycete strain. The producing organism, designated ML1-hF4, was identified as a member of the genus Amycolatopsis. Pargamicin A was identified as a novel cyclic hexapeptide antibiotic containing piperazic acid by various spectroscopic analyses. Pargamicin A showed potent antibacterial activity against Staphylococcus aureus strains including MRSA and Enterococcus faecalis/faecium strains including VRE.
authors.affiliation: Microbial Chemistry Research Center, Tokyo, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Igarashi
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Sawa
authors.forename: Naoko
authors.initials: N
authors.lastname: Kinoshita
authors.forename: Hideki
authors.initials: H
authors.lastname: Hashizume
authors.forename: Naoko
authors.initials: N
authors.lastname: Nakagawa
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Homma
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Akamatsu
mesh_terms: D000192:Actinomycetales / Q000145:classification / Q000254:growth & development / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017077:Culture Media, Conditioned / Q000378:metabolism; D013293:Enterococcus faecalis / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011724:Pyridazines / Q000032:analysis; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D017077:Culture Media, Conditioned; D010456:Peptides, Cyclic; D011724:Pyridazines; C532991:pargamicin A; C014756:piperazic acid