Thrombospondin-1 in differentiated thyroid cancer: Dr. Jekyll and Mr. Hyde.
Thrombospondin-1 (TSP-1) is a member of a family of five structurally related extracellular glycoproteins that plays a major role in cell-matrix and cell-cell interactions. Due to its multifunctional nature and its ability to bind to a variety of cell surface receptors and matrix proteins, TSP-1 has been identified as a potential regulator of angiogenesis and tumor progression. In this review, we summarize recent results that we obtained in our laboratory dealing with the regulation of thombospondin-1 expression by epidermal growth factor and hepatocyte growth factor. Our results show that TSP-1 can have opposite effects on cell invasion depending upon the type of differentiated thyroid carcinoma studied.
Ghoneim
Christelle
C
Laboratory of Biochemistry and Molecular Biology, Unité MEDyC, Faculty of Medicine URCA, Reims, France.
Soula-Rothhut
Mahdhia
M
Rothhut
Bernard
B
D002291:Carcinoma, Papillary / Q000378:metabolism / Q000473:pathology; D018265:Carcinoma, Papillary, Follicular / Q000378:metabolism / Q000473:pathology; D015536:Down-Regulation; D004815:Epidermal Growth Factor / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism*; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D019700:Thrombospondin 1 / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology; D015854:Up-Regulation
D036341:Intercellular Signaling Peptides and Proteins; D019700:Thrombospondin 1; D004815:Epidermal Growth Factor; D017228:Hepatocyte Growth Factor