title: Acute interstitial nephritis related to lansoprazole administration.
abstract: Acute interstitial nephritis (AIN) is a rare but serious adverse effect reported with proton pump inhibitors (PPIs). Only one report (2 cases) of AIN with lansoprazole is published in literature. A case of lansoprazole induced interstitial nephritis (biopsy supported) was reported in an elderly female patient admitted to the hospital with non specific symptoms after 45 days of treatment with the drug. A recovery was noticed upon withdrawal of the drug and treatment with corticosteroids. We consider this report as a valuable addition to the existing literature on this rare adverse effect with lansoprazole. This potentially serious adverse effect with PPIs including lansoprazole has to be given due consideration, especially taking into account the wide spread use of this group of agents.
authors.affiliation: Dcpartmcnt of Clinical Pharmacy, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors.forename: Jimmy
authors.initials: J
authors.lastname: Jose
authors.forename: Kavitha
authors.initials: K
authors.lastname: Saravu
authors.forename: Kanav
authors.initials: K
authors.lastname: Khera
authors.forename: Beena
authors.initials: B
authors.lastname: Jimmy
authors.forename: Barkur Anantha Krishna
authors.initials: BA
authors.lastname: Shastry
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000009:adverse effects*; D000208:Acute Disease; D000368:Aged; D000897:Anti-Ulcer Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D064747:Lansoprazole; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D064747:Lansoprazole