Hormesis and medicine.
Evidence is presented which supports the conclusion that the hormetic dose-response model is the most common and fundamental in the biological and biomedical sciences, being highly generalizable across biological model, endpoint measured and chemical class and physical agent. The paper provides a broad spectrum of applications of the hormesis concept for clinical medicine including anxiety, seizure, memory, stroke, cancer chemotherapy, dermatological processes such as hair growth, osteoporosis, ocular diseases, including retinal detachment, statin effects on cardiovascular function and tumour development, benign prostate enlargement, male sexual behaviours/dysfunctions, and prion diseases.
Calabrese
Edward J
EJ
Department of Public Health, Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA. edwardc@schoolph.umass.edu
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007928:Lethal Dose 50; D019055:No-Observed-Adverse-Effect Level; D010601:Pharmacology, Clinical / Q000379:methods*; D014116:Toxicology / Q000379:methods*