EEG and FMRI coregistration to investigate the cortical oscillatory activities during finger movement.
Electroencephalography combined with functional magnetic resonance imaging (EEG-fMRI) may be used to identify blood oxygenation level dependent (BOLD) signal changes associated with physiological and pathological EEG event. In this study we used EEG-fMRI to determine the possible correlation between topographical movement-related EEG changes in brain oscillatory activity recorded from EEG electrodes over the scalp and fMRI-BOLD cortical responses in motor areas during finger movement. Thirty-two channels of EEG were recorded in 9 subjects during eyes-open condition inside a 1.5 T magnetic resonance (MR) scanner using a MR-compatible EEG recording system. Off-line MRI artifact subtraction software was applied to obtain continuous EEG data during fMRI acquisition. For EEG data analysis we used the event-related-synchronization/desynchronization (ERS/ERD) approach to investigate where movement-related decreases in alpha and beta power are located. For image statistical analysis we used a general linear model (GLM) approach. There was a significant correlation between the positive-negative ratio of BOLD signal peaks and ERD values in the electrodes over the region of activation. We conclude that combined EEG-fMRI may be used to investigate movement-related oscillations of the human brain inside an MRI scanner and the movement-related changes in the EMG or EEG signals are useful to identify the brain activation sources responsible for BOLD-signal changes.
Formaggio
Emanuela
E
Section of Neurological Rehabilitation, Department of Neurological and Visual Sciences, Gianbattista Rossi Hospital, University of Verona, P.le Scuro, 37134, Verona, Italy. formaggio@dei.unipd.it
Storti
Silvia Francesca
SF
Avesani
Mirko
M
Cerini
Roberto
R
Milanese
Franco
F
Gasparini
Anna
A
Acler
Michele
M
Pozzi  Mucelli
Roberto
R
Fiaschi
Antonio
A
Manganotti
Paolo
P
D000328:Adult; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D003344:Cortical Synchronization / Q000379:methods; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D005385:Fingers / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008432:Mathematical Computing; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology; D009068:Movement / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult