[Efficacy and safety of 3% mepivacaine hydrochloride injection for oral local anesthesia].
OBJECTIVE
To assess the efficacy and safety of 3% mepivacaine hydrochloride injection for oral local anesthesia.


METHODS
68 non-hypertension patients and 36 hypertension patients were randomly divided into 2 groups for local anesthesia. 2% lidocaine with adrenaline in same cartridge was as control group and 3% mepivacaine was as the experimental group. The onset time,duration and pain-free time of 2 anaesthetics were examined. The blood pressure and heart rate change, neural reaction and side effect of 2 groups were observed. SAS software package was used for statistical analysis.


RESULTS
In the mepivacaine group, the average onset time was 111s, the duration time was 212s and pain-free time was 134 min ,which was similar to those of 2% lidocaine. Immediately after injection, 5 minutes and 10 minutes after injection of anesthesia, and post-operation, there were no significant changes in the systolic blood pressures between 2% lidocaine group and 3% mepivacaine group (P>0.05), but there were significant changes in diastolic blood pressures and heart rate (P<0.05).


CONCLUSIONS
3% mepivacaine has quick onset, ideal anesthetic effect and little side effect on cardiovascular system.
Ding
Sheng
S
Department of Endodontics, Ninth People's Hospital, College of Stomatology, School of Medicine, Shanghai Jiao Tong University. Shanghai 200011, China.
Zhu
Ya-Qin
YQ
Wu
Ying-Na
YN
Cao
Dong
D
D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000009:adverse effects / Q000494:pharmacology*; D004837:Epinephrine; D006801:Humans; D006973:Hypertension; D008012:Lidocaine; D008619:Mepivacaine / Q000009:adverse effects / Q000494:pharmacology*; D009055:Mouth
D000779:Anesthetics, Local; D008012:Lidocaine; D008619:Mepivacaine; D004837:Epinephrine