Individual variation in 3-methylbutanal: a putative link between human leukocyte antigen and skin microflora.
The human derma emits volatile compounds whose interaction with a receiver's olfactory sensory system may affect individual recognition and mating preferences. Studies suggest that both genes and environmental factors determine characteristic odor of an individual. We used solid-phase microextraction and gas chromatography-mass spectrometry to identify 3-methylbutanal in human axillary odor; we showed that the abundance of this volatile compound varies significantly among individuals and demonstrated that its formation in vitro may be influenced by interaction between human leukocyte antigen peptide and dermal microflora.
Savelev
Sergey U
SU
School of Marine Science and Technology, University of Newcastle, Newcastle upon Tyne, UK. s.savelev@ncl.ac.uk
Antony-Babu
Sanjay
S
Roberts
S Craig
SC
Wang
Huitu
H
Clare
Anthony S
AS
Gosling
L Morris
LM
Petrie
Marion
M
Goodfellow
Michael
M
O'Donnell
Anthony G
AG
Ward
Alan C
AC
D000328:Adult; D000447:Aldehydes / Q000032:analysis*; D000704:Analysis of Variance; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006680:HLA Antigens / Q000378:metabolism*; D006801:Humans; D008297:Male; D009812:Odorants / Q000032:analysis*; D012867:Skin / Q000276:immunology / Q000382:microbiology
D000447:Aldehydes; D006680:HLA Antigens; C032251:isovalerylaldehyde