title: Non-pharmacological management of antipsychotic-induced weight gain: systematic review and meta-analysis of randomised controlled trials.
abstract: BACKGROUND
  Antipsychotic-induced weight gain is a major concern in the treatment of psychosis. The efficacy of non-pharmacological interventions as well as the optimal intervention approach for this side-effect remain unclear.
  
  
  OBJECTIVE
  To determine the effectiveness of non-pharmacological interventions and specific treatment approaches to control antipsychotic-induced weight gain in patients with first-episode or chronic schizophrenia.
  
  
  METHODS
  Systematic review and meta-analysis of randomised controlled trials.
  
  
  RESULTS
  Ten trials were included in the meta-analysis. Adjunctive non-pharmacological interventions, either individual or group interventions, or cognitive-behavioural therapy as well as nutritional counselling were effective in reducing or attenuating antipsychotic-induced weight gain compared with treatment as usual, with treatment effects maintained over follow-up.
  
  
  CONCLUSIONS
  Non-pharmacological weight-management interventions should be a priority, particularly during the early stages of antipsychotic treatment. Preventive approaches have the potential to be more effective, acceptable, cost-efficient and beneficial.
authors.affiliation: ORYGEN Research Centre, University of Melbourne, Victoria, Australia. malvarez@unimelb.edu.au
authors.forename: Mario
authors.initials: M
authors.lastname: Alvarez-Jiménez
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Hetrick
authors.forename: César
authors.initials: C
authors.lastname: González-Blanch
authors.forename: John F
authors.initials: JF
authors.lastname: Gleeson
authors.forename: Patrick D
authors.initials: PD
authors.lastname: McGorry
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D006801:Humans; D009765:Obesity / Q000139:chemically induced* / Q000628:therapy; D016032:Randomized Controlled Trials as Topic; D012559:Schizophrenia / Q000188:drug therapy; D015430:Weight Gain
chemical_list: D014150:Antipsychotic Agents