title: Role of nitric oxide synthase gene intron 4 and exon 7 polymorphisms in obstructive sleep apnea syndrome.
abstract: The objective of our study was to assess the association of eNOS4 and eNOS296 polymorphisms of endothelial nitric oxide synthase (eNOS) gene with obstructive sleep apnea syndrome (OSAS). Forty-eight patients with OSAS and 181 healthy volunteers were included in the study. Genotype analyses were performed for eNOS intron 4 VNTR and exon 7, Glu298Asp (G --> T) polymorphisms. There was no significant difference between the patients and controls regarding eNOS4 polymorphism (P > 0.05). There was a significant difference between the patients and controls regarding eNOS296 polymorphism. Glu/Asp variant was more frequent whereas Glu/Glu variant was less frequent in the patients compared to controls (P < 0.001). There was no relationship between eNOS4 and eNOS296 polymorphisms and polysomnography parameters, apnea-hypopnea index, age, gender, body weight and height, body mass index, hypertension, coronary artery disease, arrhythmia, diabetes mellitus, hypercholesterolemia and smoking (P > 0.05). The eNOS4 polymorphism of NOS gene is not associated with OSAS. However, eNOS296 polymorphism of NOS gene is associated with occurrence of OSAS, but not with severity of OSAS.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey.
authors.forename: Yildirim A
authors.initials: YA
authors.lastname: Bayazit
authors.forename: Metin
authors.initials: M
authors.lastname: Yilmaz
authors.forename: Emin
authors.initials: E
authors.lastname: Erdal
authors.forename: Tansu Ulukavak
authors.initials: TU
authors.lastname: Ciftci
authors.forename: Alper
authors.initials: A
authors.lastname: Ceylan
authors.forename: Oguz
authors.initials: O
authors.lastname: Kokturk
authors.forename: Fatih
authors.initials: F
authors.lastname: Celenk
authors.forename: Yusuf K
authors.initials: YK
authors.lastname: Kemaloglu
mesh_terms: D000328:Adult; D000368:Aged; D005091:Exons / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D019001:Nitric Oxide Synthase / Q000235:genetics* / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D017286:Polysomnography; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000201:enzymology* / Q000235:genetics*
chemical_list: D019001:Nitric Oxide Synthase