title: Remarkable DNA binding affinity and potential anticancer activity of pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide conjugates linked through piperazine side-armed alkane spacers.
abstract: A series of pyrrolobenzodiazepine-naphthalimide conjugates tethered through a piperazine ring system have been designed, synthesized, and evaluated for their anticancer activity. These new conjugates exhibit very high DNA binding affinity and cytotoxic activity against a number of cell lines.
authors.affiliation: Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India. ahmedkamal@iict.res.in
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal
authors.forename: R
authors.initials: R
authors.lastname: Ramu
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Tekumalla
authors.forename: G B Ramesh
authors.initials: GB
authors.lastname: Khanna
authors.forename: Madan S
authors.initials: MS
authors.lastname: Barkume
authors.forename: Aarti S
authors.initials: AS
authors.lastname: Juvekar
authors.forename: Surekha M
authors.initials: SM
authors.lastname: Zingde
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D053644:Naphthalimides / Q000737:chemistry* / Q000494:pharmacology*; D009691:Nucleic Acid Denaturation; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D053644:Naphthalimides; D004247:DNA