A novel function of adenomatous polyposis coli (APC) in regulating DNA repair.
Prevailing literature suggests diversified cellular functions for the adenomatous polyposis coli (APC) gene. Among them a recently discovered unique role of APC is in DNA repair. The APC gene can modulate the base excision repair (BER) pathway through an interaction with DNA polymerase beta (Pol-beta) and flap endonuclease 1 (Fen-1). Taken together with the transcriptional activation of APC gene by alkylating agents and modulation of BER activity, APC may play an important role in carcinogenesis and chemotherapy by determining whether cells with DNA damage survive or undergo apoptosis. In this review, we summarize the evidence supporting this novel concept and suggest that these results will have implications for the development of more effective strategies for chemoprevention, prognosis and chemotherapy of certain types of tumors.
Jaiswal
Aruna S
AS
Department of Anatomy and Cell Biology and UF Shands Cancer Center, College of Medicine, University of Florida, Room 255, 1376 Mowry Road, Gainesville, FL 32610, United States.
Narayan
Satya
S
D000477:Alkylating Agents / Q000494:pharmacology; D019951:DNA Polymerase beta / Q000378:metabolism; D004260:DNA Repair; D045585:Flap Endonucleases / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D017491:Genes, APC; D006801:Humans
D000477:Alkylating Agents; D019951:DNA Polymerase beta; D045585:Flap Endonucleases