[Initial results of the treatment of six patients with high risk neuroblastoma in the years 2002--2006].
Between the years 2002 and 2006 in the Department of Paediatrics, Haematology, Oncology and Endocrinology, Medical University of Gdansk, six patients with neuroblastoma were qualified for the high risk group. Aim of the study was the evaluation of treatment results after using new methods of therapy.


METHODS
Intensive multimodal therapy according to the new European protocol HR-NBL-1/ESIOP, was implemented in 6 children. In two cases the high risk group qualification was delayed. Mean time of observation was 2 years 4 months.


RESULTS
After the end of therapy, three of six children remain in complete remission. The histopathology of the tumour was assessed according to Shimada classification. Number of NMYC copies was estimated by the FISH method. One patient died of infection after high dose chemotherapy. Relapses occurred in two patients. One of them died of progression and the other is alive, in the third relapse, with progression of disease.


CONCLUSIONS
The preliminary analysis shows good results of the new protocol in half of the patients. Further additional cooperative studies with bigger groups of patients are required.
Drozyńska
Elzbieta
E
Klinika Pediatrii, Hematologii, Onkologii i Endokrynologii, Akademia Medyczna, ul. Debinki 7, 80-211 Gdańsk, Poland. drozd@wp.pl
Stefanowicz
Joanna
J
Izycka-Swieszewska
Ewa
E
Balcerska
Anna
A
Bień
Ewa
E
Czauderna
Piotr
P
Połczyńska
Katarzyna
K
Rozkosz
Jan
J
Szołkiewicz
Anna
A
Stachowicz
Teresa
T
Szutowicz
Ewa
E
D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D009447:Neuroblastoma / Q000175:diagnosis* / Q000628:therapy*; D011044:Poland; D012307:Risk Factors; D016896:Treatment Outcome