Short-term clinical exposure evaluation of a third-generation electrically heated cigarette smoking system (EHCSS) in adult smokers.
This randomized, controlled, forced-switching, open-label, parallel-group, single-center study in 100 male and female adult smokers evaluated 12 biomarkers of tobacco smoke exposure. We measured exposure to the following smoke constituents: nicotine, pyrene, tobacco-specific nitrosamines, three aromatic amines, carbon monoxide, benzene, acrolein, crotonaldehyde, and 1,3-butadiene. After baseline exposure determination, adult smokers of a conventional cigarette (CC) were switched to an electrically heated cigarette smoking system (EHCSS, Series K), continued smoking the CC, or stopped smoking (No-smoking) for 8 days in a controlled, confined, clinical setting. In the EHCSS group, the mean decrease from Baseline to Day 8 in the biomarkers of exposure ranged from 16% to 77% at Day 8 compared to Baseline. After adjusting for the residual effect (carryover effects due to long elimination half-life and non-tobacco confounding sources of exposure), the mean percent decrease from Baseline for all 12 biomarkers ranged from 47% to 90%. In conclusion, switching for 8 days from a conventional cigarette to the EHCSS substantially reduced exposure of adult smokers to several constituents of both the particulate and gas phases of cigarette smoke.
Frost-Pineda
Kimberly
K
Philip Morris USA, Research Center, Clinical Evaluation, 4201 Commerce Road, Richmond, VA 23224, USA.
Zedler
Barbara K
BK
Oliveri
Douglas
D
Feng
Shixia
S
Liang
Qiwei
Q
Roethig
Hans J
HJ
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D004560:Electricity; D005260:Female; D006207:Half-Life; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008875:Middle Aged; D052638:Particulate Matter / Q000737:chemistry*; D012907:Smoking / Q000378:metabolism*; D013997:Time Factors; D014028:Tobacco Smoke Pollution / Q000032:analysis*; D055815:Young Adult
D015415:Biomarkers; D052638:Particulate Matter; D014028:Tobacco Smoke Pollution