Synthesis of bioinorganic antimicrobial peptide nanoparticles with potential therapeutic properties.
Amphiphilicity and cationicity are properties shared between antimicrobial peptides and proteins that catalyze biomineralization reactions. Merging these two functionalities, we demonstrate a reaction where a cationic antimicrobial peptide catalyzes self-biomineralization within inorganic matrices. The resultant antimicrobial peptide nanoparticles retain biocidal activity, protect the peptide from proteolytic degradation, and facilitate a continuous release of the antibiotic over time. Taken together, these properties demonstrate the therapeutic potential of self-synthesizing biomaterials that retain the biocidal properties of antimicrobial peptides.
Eby
D Matthew
DM
Universal Technology Corporation, Applied Research Associates, Inc., Florida, USA. matt.eby.ctr@tyndall.af.mil
Farrington
Karen E
KE
Johnson
Glenn R
GR
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects*; D002384:Catalysis; D002412:Cations / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004058:Diffusion; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects*; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D002412:Cations; D009842:Oligopeptides; C009495:titanium dioxide; D012822:Silicon Dioxide; D014025:Titanium