title: Low plasma pyridoxal 5'-phosphate concentration and MTHFR 677C-->T genotypes are associated with increased risk of hypertension.
abstract: Few studies have linked homocysteine, B vitamins and/or genetic defects to the risk of hypertension. The purpose of this study was to investigate homocysteine, B-vitamins, and genetic mutation in relation to the risk of hypertension. Subjects were assigned to the hypertension (HTN) group (n = 50) or non-hypertension (non-HTN) group (n = 123). All subjects' blood pressure (systolic blood pressure, SBP; diastolic blood pressure, DBP), biochemical values, plasma homocysteine, pyridoxal 5'-phosphate (PLP), serum folate, vitamin B12 concentrations, and methylenetetrafolate reductase (MTHFR) 677C-->T gene polymorphism were measured. Results showed that subjects with T-allele were positively associated with DBP (beta = 4.22, p = 0.04) but the significance became weaker (p = 0.06) after homocysteine and B vitamins were additionally adjusted. A significant association of plasma PLP with SBP remained (beta = -0.06, p = 0.01) even after homocysteine and T-allele genotypes were additionally adjusted (beta = -0.07, p = 0.02). The combined presence of low PLP (< 30 nmol/L) and carried T-allele enhanced the risk of hypertension and the risk magnitude was substantially greater (OR, 16.44, p < 0.001). Taken together, the results show that low plasma PLP levels and MTHFR 677C-->T genotypes might be significant risk factors for hypertension.
authors.affiliation: School of Nutrition and Institute of Nutritional Science, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Ping-Ting
authors.initials: PT
authors.lastname: Lin
authors.forename: Chien-Hsiang
authors.initials: CH
authors.lastname: Cheng
authors.forename: James Cheng-Chung
authors.initials: JC
authors.lastname: Wei
authors.forename: Yi-Chia
authors.initials: YC
authors.lastname: Huang
mesh_terms: D000483:Alleles; D001794:Blood Pressure; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005492:Folic Acid / Q000097:blood; D005838:Genotype; D006801:Humans; D006867:Hydrolases / Q000097:blood*; D006973:Hypertension / Q000097:blood* / Q000235:genetics*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D011732:Pyridoxal Phosphate / Q000097:blood*; D012307:Risk Factors
chemical_list: D011732:Pyridoxal Phosphate; D005492:Folic Acid; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D006867:Hydrolases; C463961:homocysteinase