title: Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM.
abstract: The associations of the C825T polymorphism (rs5443) of the G-protein beta3 subunit (GNB3) gene and eight adjacent single nucleotide polymorphisms (SNPs) with diabetes were examined using a Japanese population (n (M/W): 2956 (1335/1621); age: 63.0+/-10.2 years). Fasting plasma glucose (FPG) levels were significantly associated with the C825T polymorphism and two flanking SNPs (rs2301339 and rs5446) (p=0.002, 0.001, and 0.008, respectively). A case-control association study of the C825T polymorphism with diabetes using multiple logistic regression analysis showed a significant association of the genotypes TT+TC with an odds ratio of 0.62 (p=0.008) independent of age, gender, and BMI. The effects of salt consumption on the association were then examined (n=1635). The FPG levels were significantly associated with the C825T polymorphism only in subjects with low salt consumption (<12.44 g/day) (p=0.002). A case-control association study also showed a significant association with diabetes only in subjects with low salt consumption (p=0.006).
authors.affiliation: Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990 9585, Japan. mdaimon@med.id.yamagata-u.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Daimon
authors.forename: Hidenori
authors.initials: H
authors.lastname: Sato
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sasaki
authors.forename: Sayumi
authors.initials: S
authors.lastname: Toriyama
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Emi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Muramatsu
authors.forename: Steven C
authors.initials: SC
authors.lastname: Hunt
authors.forename: Paul N
authors.initials: PN
authors.lastname: Hopkins
authors.forename: Shigeru
authors.initials: S
authors.lastname: Karasawa
authors.forename: Kiriko
authors.initials: K
authors.lastname: Wada
authors.forename: Yumi
authors.initials: Y
authors.lastname: Jimbu
authors.forename: Wataru
authors.initials: W
authors.lastname: Kameda
authors.forename: Shinji
authors.initials: S
authors.lastname: Susa
authors.forename: Toshihide
authors.initials: T
authors.lastname: Oizumi
authors.forename: Akira
authors.initials: A
authors.lastname: Fukao
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
authors.forename: Sumio
authors.initials: S
authors.lastname: Kawata
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D001786:Blood Glucose; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D005215:Fasting; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; C454420:G-protein beta3 subunit; D017673:Sodium Chloride, Dietary; D020962:Heterotrimeric GTP-Binding Proteins