title: Inhibition of LFA-1 mediated T-cell motility by naphthoquinones.
abstract: An in vitro T-cell migration assay has been established that can be used to study the effects of compounds on the development of T-cell polarisation with HuT-78 T lymphocytes. This assay indicates the ability of compounds tested to inhibit the inflammatory response by decreasing LFA-1-mediated T-cell motility. The effect of a series of naturally occurring quinone isolates on motility has been evaluated in this assay. Distinct differences have been observed between naphthoquinones, dihydrofuranonaphthoquinones and anthraquinones.
authors.affiliation: Trinity College Dublin, School of Pharmacy & Pharmaceutical Sciences, Panoz Institute, Dublin, Ireland. hsheridn@tcd.ie
authors.forename: Helen
authors.initials: H
authors.lastname: Sheridan
authors.forename: Ingrid
authors.initials: I
authors.lastname: Hook
authors.forename: Cora
authors.initials: C
authors.lastname: Nestor
authors.forename: Jennifer
authors.initials: J
authors.lastname: Coppins
authors.forename: Carsten
authors.initials: C
authors.lastname: Ehrhardt
authors.forename: Neil
authors.initials: N
authors.lastname: Frankish
mesh_terms: D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects*; D006801:Humans; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism*; D009285:Naphthoquinones / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism
chemical_list: D016169:Lymphocyte Function-Associated Antigen-1; D009285:Naphthoquinones