Transplantation of allogenic cells in the therapy of patients with dilated cardiomyopathy.
We carried out a pilot study on intracoronary transplantation of prenatal allogenic skeletal myoblasts and multipotent bone marrow stromal cells to patients with dilated cardiomyopathy. Intracoronary transplantation of allogenic cells is a feasible and safe procedure: there were no life-threatening rhythm and conduction disturbances, symptoms of hemodynamic instability, and thromboembolic complications. Positive clinical effect of cell transplantation persisted for 6 months and consisted in decreased content of brain natriuretic peptide and improved tolerance to physical exercises. We observed no reliable dynamics of the major echocardiographic parameters and their correlations with patient's status.
Kirillov
A M
AM
B. V. Petrovskii Russian Research Surgical Center, Russian Academy of Medical Sciences, Moscow.
Fatkhudinov
T Kh
TKh
Dyachkov
A V
AV
Koroteev
A V
AV
Goldshtein
D V
DV
Bochkov
N P
NP
D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells / Q000166:cytology; D016026:Bone Marrow Transplantation / Q000379:methods*; D002311:Cardiomyopathy, Dilated / Q000473:pathology / Q000601:surgery*; D017690:Cell Transplantation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D032448:Myoblasts, Skeletal / Q000166:cytology; D010865:Pilot Projects; D017154:Stromal Cells / Q000166:cytology / Q000637:transplantation; D014184:Transplantation, Homologous; D016896:Treatment Outcome