Diazinium salts with dihydroxyacetophenone skeleton: Syntheses and antimicrobial activity.
Herein we report a feasible study concerning syntheses, structure and antimicrobial activity of some new diazinium salts with dihydroxyacetophenone skeleton. A fast, general, environmentally friendly, and facile method for preparation of diazinium salts under microwave and ultrasounds irradiation is presented. Antimicrobial tests prove that some diazine compounds have a remarkable activity against different microorganisms (germs and fungi), the pyrimidine derivatives being more active. Correlations between structure and antimicrobial activity are reported.
Balan
Ana Maria
AM
"Al. I. Cuza" University of Iasi, Organic and Biochemistry Department, Bd. Carol 11, 700506 Iasi, Romania.
Florea
Ondina
O
Moldoveanu
Costel
C
Zbancioc
Gheorghita
G
Iurea
Dorina
D
Mangalagiu
Ionel I
II
D000098:Acetophenones / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005240:Feasibility Studies; D055772:Green Chemistry Technology; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D013329:Structure-Activity Relationship
D000098:Acetophenones; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; C019339:2,6-dihydroxyacetophenone