[Influence of dichlorodiphenyldichloroethylene on 1,2 dimethylhydrazine-induced androgen-dependent renal capsule angiosarcoma development].
The study was concerned with the influence of dichlorodiphenyldichloroethylene (p,p'-DDE) on 1,2 dimethylhydrazine (DMH)-induced androgen-dependent renal capsule angiosarcoma (RCA) in male CBA mice. p,p'-DDE was shown to significantly decrease the incidence of DMH-induced RCA (69.0% vs. 44.1%). That could be accounted for by the anti-androgen affinity of p,p'-DDE. It is suggested that exposure to p,p'-DDE might inhibit androgen-receptor containing tumors.
Morozova
O V
OV
Trukhanova
L S
LS
Turusov
V S
VS
D019813:1,2-Dimethylhydrazine / Q000633:toxicity*; D000726:Androgen Antagonists / Q000494:pharmacology*; D000728:Androgens / Q000378:metabolism*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D003633:Dichlorodiphenyl Dichloroethylene / Q000494:pharmacology*; D006394:Hemangiosarcoma / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D007306:Insecticides / Q000494:pharmacology; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D000726:Androgen Antagonists; D000728:Androgens; D002273:Carcinogens; D007306:Insecticides; D003633:Dichlorodiphenyl Dichloroethylene; D019813:1,2-Dimethylhydrazine