title: Convergent synthesis and biological activity of the WXYZA'B'C' ring system of maitotoxin.
abstract: The WXYZA'B'C' ring system ( 1) of maitotoxin (MTX) was synthesized in a convergent manner via successive coupling of the W, Z, and C' ring fragments through construction of the XY and A'B' ring systems. The synthetic segment 1 blocked the hemolytic activity elicited by MTX.
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan. oishi@chem.sci.osaka-u.ac.jp
authors.forename: Tohru
authors.initials: T
authors.lastname: Oishi
authors.forename: Futoshi
authors.initials: F
authors.lastname: Hasegawa
authors.forename: Kohei
authors.initials: K
authors.lastname: Torikai
authors.forename: Keiichi
authors.initials: K
authors.lastname: Konoki
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Matsumori
authors.forename: Michio
authors.initials: M
authors.lastname: Murata
mesh_terms: D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008387:Marine Toxins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008968:Molecular Conformation; D035964:Oxocins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000095702:Polyether Toxins
chemical_list: D008387:Marine Toxins; D035964:Oxocins; C020394:maitotoxin; D000095702:Polyether Toxins