A PASport to cellular proliferation.
The use of alternative polyadenylation sites produces mRNA isoforms with different 3' untranslated regions. A recent report in Science (Sandberg et al., 2008) suggests that alternative polyadenylation is connected to microRNA-mediated regulation of gene expression as part of a global program for cellular proliferation.
Zlotorynski
Eitan
E
The Netherlands Cancer Institute, Division of Gene Regulation, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.
Agami
Reuven
R
D020413:3' Untranslated Regions / Q000378:metabolism*; D000818:Animals; D049109:Cell Proliferation; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D026723:Polyadenylation; D012333:RNA, Messenger / Q000378:metabolism
D020413:3' Untranslated Regions; D035683:MicroRNAs; D012333:RNA, Messenger