Coupling across a DNA helical turn yields a hybrid DNA/organic catenane doubly tailed with functional termini.
We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.
Liu
Yu
Y
Department of Chemistry, New York University, New York, New York 10003, USA.
Kuzuya
Akinori
A
Sha
Ruojie
R
Guillaume
Johan
J
Wang
Risheng
R
Canary
James W
JW
Seeman
Nadrian C
NC
D000873:Anthracenes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000528:radiation effects; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry / Q000528:radiation effects; D013237:Stereoisomerism; D014466:Ultraviolet Rays
D000873:Anthracenes; D009841:Oligonucleotides; C467767:catenane; D004247:DNA