title: Quantification of brain maturation and growth patterns in C57BL/6J mice via computational neuroanatomy of diffusion tensor images.
abstract: Diffusion Tensor magnetic resonance imaging and computational neuroanatomy are used to quantify postnatal developmental patterns of C57BL/6J mouse brain. Changes in neuronal organization and myelination occurring as the brain matures into adulthood are examined, and a normative baseline is developed, against which transgenic mice may be compared in genotype-phenotype studies. In early postnatal days, gray matter-based cortical and hippocampal structures exhibit high water diffusion anisotropy, presumably reflecting the radial neuronal organization. Anisotropy drops rapidly within a week, indicating that the underlying brain tissue becomes more isotropic in orientation, possibly due to formation of a complex randomly intertwined web of dendrites. Gradual white matter anisotropy increase implies progressively more organized axonal pathways, likely reflecting the myelination of axons forming tightly packed fiber bundles. In contrast to the spatially complex pattern of tissue maturation, volumetric growth is somewhat uniform, with the cortex and the cerebellum exhibiting slightly more pronounced growth. Temporally, structural growth rates demonstrate an initial rapid volumetric increase in most structures, gradually tapering off to a steady state by about 20 days. Fiber maturation reaches steady state in about 10 days for the cortex, to 30-40 days for the corpus callosum, the hippocampus, and the internal and external capsules.
authors.affiliation: Department of Radiology, University of Pennsylvania, PA 19104, USA. sajjad.baloch@gmail.com
authors.forename: Sajjad
authors.initials: S
authors.lastname: Baloch
authors.forename: Ragini
authors.initials: R
authors.lastname: Verma
authors.forename: Hao
authors.initials: H
authors.lastname: Huang
authors.forename: Parmeshwar
authors.initials: P
authors.lastname: Khurd
authors.forename: Sarah
authors.initials: S
authors.lastname: Clark
authors.forename: Paul
authors.initials: P
authors.lastname: Yarowsky
authors.forename: Ted
authors.initials: T
authors.lastname: Abel
authors.forename: Susumu
authors.initials: S
authors.lastname: Mori
authors.forename: Christos
authors.initials: C
authors.lastname: Davatzikos
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005069:Evaluation Studies as Topic; D005260:Female; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL