title: Increased regional cerebral perfusion in contralateral motor and somatosensory areas after median nerve stimulation therapy.
abstract: OBJECTIVE
  To evaluate change in regional cerebral perfusion (rCBF) after median nerve stimulation (MNS) therapy in brain-damaged patients.
  
  
  METHODS
  Twelve brain-damaged patients received 12 courses of MNS. Technetium-99m-ethyl cysteinate diethylester (99mTc-ECD) SPECT was performed before and 4 weeks after MNS initiation. Clinical response was assessed by Glasglow coma scale or clinical improvement. 12 MNS patients were grouped as good responder (GR) (n = 6) and poor responder (PR) (n = 6) according to therapy response. Scan images were analyzed by Statistical Parametric Mapping 2 (SPM2).
  
  
  RESULTS
  In the GR group, paired Student t test between the pre- and post-MNS images showed 2 activation clusters over the left frontal and parietal lobes, including regions of the precentral gyrus, middle frontal gyrus, superior frontal gyrus, subgyral, inferior parietal lobule, and postcentral gyms (corresponding to Brodmann areas 4, 6, and 40). In the PR group, paired Student t test did not show any activation clusters. Clusters with significant differences between the GR and PR groups shared no mutual voxels with those clusters having significant regional effects after MNS in the GR group.
  
  
  CONCLUSIONS
  Median nerve stimulation enhanced the rCBF of the contralateral motor and somatosensory cortex, which is compatible with the few previous studies using other modalities.
authors.affiliation: Department of Neurosurgery, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: J-T
authors.initials: JT
authors.lastname: Liu
authors.forename: J-K
authors.initials: JK
authors.lastname: Lee
authors.forename: P-J
authors.initials: PJ
authors.lastname: Chang
authors.forename: C-M
authors.initials: CM
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001925:Brain Damage, Chronic / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology / Q000528:radiation effects*; D004599:Electric Stimulation Therapy / Q000379:methods*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology / Q000528:radiation effects*; D008875:Middle Aged; D009044:Motor Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals; D013003:Somatosensory Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime