title: Change in leptin, body composition and other hormones around menarche--a visual representation.
abstract: OBJECTIVE
  To present a visual representation of changes in body composition, leptin, insulin, estradiol and follicular stimulating hormone (FSH) levels in relation to menarche in girls.
  
  
  METHODS
  Participants were a subset of healthy girls (n = 108) enrolled in a longitudinal study of growth and development conducted at the General Clinical Research Center at the Massachusetts Institute of Technology (MIT). Participants were seen annually from before menarche until 4 years postmenarche for measures of body composition and serum levels of leptin, insulin, estradiol and FSH. Body composition was determined by bioelectrical impedance. Standardized body composition and hormone levels were smoothed and plotted relative to menarche to visualize patterns of change.
  
  
  RESULTS
  At menarche, the mean percentage body fat (%BF) of girls was 24.6% (SD = 4.1%) after menarche %BF was approximately 27%. Leptin levels averaged 8.4 ng/mL (SD = 4.6) at menarche and were approximately 12 ng/mL after menarche. Changes in leptin levels closely paralleled changes in %BF. Insulin, estradiol and FSH levels followed expected patterns relative to menarche. Leptin began rising closer to menarche than did insulin or the other sex hormones.
  
  
  CONCLUSIONS
  We provide a visual presentation of hormonal and body composition changes occurring throughout the pubertal period in girls which may be useful in generating new hypotheses related to the timing of menarche.
authors.affiliation: Eunice Kennedy Shriver Center, University of Massachusetts Medical School, Waltham, MA, USA.
authors.forename: L G
authors.initials: LG
authors.lastname: Bandini
authors.forename: A
authors.initials: A
authors.lastname: Must
authors.forename: E N
authors.initials: EN
authors.lastname: Naumova
authors.forename: Se
authors.initials: S
authors.lastname: Anderson
authors.forename: S
authors.initials: S
authors.lastname: Caprio
authors.forename: J I
authors.initials: JI
authors.lastname: Spadano-Gasbarro
authors.forename: W H
authors.initials: WH
authors.lastname: Dietz
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001823:Body Composition; D002648:Child; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008137:Longitudinal Studies; D008572:Menarche; D010809:Physical Fitness
chemical_list: D012739:Gonadal Steroid Hormones; D007328:Insulin; D020738:Leptin; D004958:Estradiol; D005640:Follicle Stimulating Hormone