Natural Chagas disease in four baboons.
BACKGROUND
Chagas disease is common in Central and South America and the southern United States. The causative agent is Trypanosoma cruzi (order Kinetoplastida, family Trypanosomatidae), a kinetoplastid protozoan parasite of humans and other vertebrates. It is a serious public health issue and the leading cause of heart disease and cardiovascular death in Central and South America. In 1984, a colony baboon was discovered to be infected with T. cruzi.


METHODS
As the initial diagnosis was made by microscopic observation of the amastigote forms of T. cruzi in myocardial fibers, T. cruzi amastigotes have been identified in three additional baboons.


RESULTS
The primary findings were similar in all four baboons and were congestive heart failure with edema of dependent areas, hydrothorax, hydropericardium, and multifocal to diffuse lymphoplasmacytic myocarditis.


CONCLUSIONS
A baboon animal model of Chagas disease could contribute significantly to the development of therapies for the disease in humans.
Williams
Jeff T
JT
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.
Dick
Edward J
EJ
VandeBerg
John L
JL
Hubbard
Gene B
GB
D000818:Animals; D014355:Chagas Disease / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008297:Male; D008992:Monkey Diseases / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D010215:Papio; D014349:Trypanosoma cruzi / Q000472:pathogenicity