title: Changes in cerebral hemodynamics and amplitude integrated EEG in an asphyxiated newborn during and after cool cap treatment.
abstract: Amplitude integrated EEG (aEEG) and Near Infrared Spectroscopy (NIRS) were applied in a newborn with a moderate hypoxic-ischemic encephalopathy before, during and after brain cooling. At 2h of life a selective head cooling with mild systemic hypothermia was started and maintained for 72h. aEEG background pattern improved from severely abnormal to normal during the first 17h of life. NIRS revealed a reduction in cerebral blood volume (CBV) during hypothermia that recovered during the rewarming period, whereas brain oxygenation remained stable. As brain cooling is supposed to reduce delayed hyperemia and help to maintain neuronal metabolism following cerebral insults, aEEG and NIRS monitoring may be useful during hypothermic treatment in order to document changes in CBV and brain oxygenation possibly reflecting the efficacy of hypothermia.
authors.affiliation: Institute of Neonatology, University of Bologna, Via Massarenti 11, Bologna, Italy. ancora@med.unibo.it
authors.forename: Gina
authors.initials: G
authors.lastname: Ancora
authors.forename: Eugenia
authors.initials: E
authors.lastname: Maranella
authors.forename: Chiara
authors.initials: C
authors.lastname: Locatelli
authors.forename: Luca
authors.initials: L
authors.lastname: Pierantoni
authors.forename: Giacomo
authors.initials: G
authors.lastname: Faldella
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications*; D001831:Body Temperature / Q000502:physiology; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004185:Disability Evaluation; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D006439:Hemodynamics / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis / Q000378:metabolism; D006801:Humans; D006940:Hyperemia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D007036:Hypothermia, Induced / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D007231:Infant, Newborn; D009682:Magnetic Resonance Spectroscopy; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods; D010101:Oxygen Consumption / Q000502:physiology; D011237:Predictive Value of Tests; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013995:Time
chemical_list: D006454:Hemoglobins