title: Effects of subchronic exposure to LASSO MTX (alachlor 42% W/V) on hematological indices and histology of the common Carp, Cyprinus carpio L.
abstract: The aim of the study was to evaluate subchronic toxic effects of the preparation LASSO MTX (alachlor 42% W/V) on hematological indices and histology of the common carp (Cyprinus carpio L.). In carp exposed for 28 days to LASSO MTX in the concentration of 2,400 microg L(-1), significant differences (p < 0.05), were detected in all indices of the erythrocyte profiles tested except hematocrit (PCV) when compared to controls. At a lower exposure (240 microg L(-1)) concentration of blood hemoglobin and mean corpuscular hemoglobin were significantly reduced. In contrast, no influence of the preparation on leucopoiesis was demonstrated, and only slight changes were observed in histopathological indices.
authors.affiliation: Department of Veterinary Public Health and Toxicology, University of Veterinary and Pharmaceutical Sciences, Faculty of Veterinary Hygiene and Ecology, Palackeho 1-3, 612 42 Brno, Czech Republic. premysl.mikula@centrum.cz
authors.forename: Premysl
authors.initials: P
authors.lastname: Mikula
authors.forename: Helena
authors.initials: H
authors.lastname: Modra
authors.forename: Danka
authors.initials: D
authors.lastname: Nemethova
authors.forename: Ladislav
authors.initials: L
authors.lastname: Groch
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Svobodova
mesh_terms: D000081:Acetamides / Q000633:toxicity*; D000747:Anemia, Hypochromic / Q000097:blood; D000818:Animals; D001772:Blood Cell Count; D002347:Carps / Q000502:physiology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005618:Fresh Water / Q000032:analysis; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D043143:Hepatopancreas / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D006540:Herbicides / Q000633:toxicity*
chemical_list: D000081:Acetamides; D006454:Hemoglobins; D006540:Herbicides; C000188:alachlor