Breast cancer cells exhibit selective modulation induced by different collagen substrates.
During the invasive phase of malignant tumors, neoplastic cells break into the basal lamina and enter in contact with the underlying connective tissue, which concurrently undergoes extensive modifications. The aim of our present minireview is to focus the changes in the collagenous matrix occurring during breast cancer progression and to explore the possible effects of different collagen substrates on breast cancer cell behavior and proteomic modulation.
Pucci-Minafra
Ida
I
Dipartimento di Oncologia Sperimentale e Applicazioni Cliniche, Universita di Palermo, Palermo, Italy. idapucci@unipa.it
Albanese
Nadia N
NN
Di Cara
Gianluca
G
Minafra
Luigi
L
Marabeti
Maria Rita
MR
Cancemi
Patrizia
P
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D003094:Collagen / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D040901:Proteomics; D017154:Stromal Cells / Q000648:ultrastructure
D003094:Collagen