More than two sides of a coin? How to detect the multiple activities of type 2 transglutaminase.
Programmed cell death (PCD) by apoptosis has been widely characterized as a process in which the expression and protein activation of a gene must be regulated in a very precise way in order to achieve the elimination of the dying cell without disturbing the neighborhoods. One of the first genes observed to be induced during the onset of PCD is the one coding for type 2 transglutaminase (TG2). Since the late 1990s, the unveiling of different new properties and enzymatic activities suggested the involvement of TG2 in a variety of cellular processes other than PCD and rendered the study of this protein more and more complicated.
Rodolfo
Carlo
C
Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Falasca
Laura
L
Di Giacomo
Giuseppina
G
Mastroberardino
Pier Giorgio
PG
Piacentini
Mauro
M
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D019921:Biotinylation; D005455:Fluorescent Antibody Technique; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D018345:Mice, Knockout; D010587:Phagocytosis; D011503:Transglutaminases / Q000378:metabolism*
D011503:Transglutaminases