title: From KISS1 to kisspeptins: An historical perspective and suggested nomenclature.
abstract: The cancer suppressor gene, KISS1, was initially described as having an important role in inhibiting cancer metastasis. Since then, KISS1 and its receptor, KISS1R, have been shown to play a key role in controlling the onset of puberty of reproductive physiology in the human and other species. Recent studies have also linked KISS1/kisspeptin/KISS1R to other processes, such as vasoconstriction, aging, adipocyte physiology, and perhaps as a molecular conduit linking metabolism and reproduction. This article highlights the history of KISS1/kisspeptin/KISS1R biology and proposes a consensus for nomenclature of the key molecules in this signaling pathway.
authors.affiliation: Department of Obstetrics & Gynecology, University of Washington, Box 356460, 1959 NE Pacific Street, Seattle, WA 98195-6460, USA. gottsm@u.washington.edu
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Gottsch
authors.forename: Donald K
authors.initials: DK
authors.lastname: Clifton
authors.forename: Robert A
authors.initials: RA
authors.lastname: Steiner
mesh_terms: D000818:Animals; D006801:Humans; D007031:Hypothalamus / Q000166:cytology / Q000378:metabolism; D059648:Kisspeptins; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism; D000074502:Receptors, Kisspeptin-1; D012098:Reproduction / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D009626:Terminology as Topic; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: C106628:KISS1 protein, human; C118688:KISS1R protein, human; D059648:Kisspeptins; D043562:Receptors, G-Protein-Coupled; D000074502:Receptors, Kisspeptin-1; D025521:Tumor Suppressor Proteins