title: Silicates and bone fusion.
abstract: Autologous bone grafting remains the gold standard for bone grafting in clinical practice. Although it has withstood the test of time, it remains associated with multiple comorbidities. The search for an alternative bone graft substitute harnessing bone's osteoconductive, osteoinductive, and osteogenic properties remains a challenge. This article examines the various bone grafting materials currently in use and highlights the current properties and uses of silicon-substituted calcium phosphates as a competitive substitute for high cost materials used today.
authors.affiliation: Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06520-8071, USA.
authors.forename: Walid
authors.initials: W
authors.lastname: Waked
authors.forename: Jonathan
authors.initials: J
authors.lastname: Grauer
mesh_terms: D001861:Bone Regeneration / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods*; D006801:Humans; D019279:Resin Cements / Q000494:pharmacology*; D012821:Silanes / Q000494:pharmacology*; D017640:Silicates / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D019279:Resin Cements; D012821:Silanes; D017640:Silicates; C061500:Fusion (silane derivative)