title: Triazole-linked analogue of deoxyribonucleic acid ((TL)DNA): design, synthesis, and double-strand formation with natural DNA.
abstract: A new triazole-linked analogue of DNA ((TL)DNA) has been designed and synthesized using click chemistry. The chain elongation reaction using copper-catalyzed Huisgen cycloaddition was successful and gave the artificial oligonucleotide that formed a stable double strand with the complementary strand of natural DNA.
authors.affiliation: Department of Chemistry, Tohoku University, Aoba-ku, Sendai 980-8578, Japan. isobe@mail.tains.tohoku.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Isobe
authors.forename: Tomoko
authors.initials: T
authors.lastname: Fujino
authors.forename: Naomi
authors.initials: N
authors.lastname: Yamazaki
authors.forename: Marine
authors.initials: M
authors.lastname: Guillot-Nieckowski
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nakamura
mesh_terms: D003300:Copper / Q000737:chemistry; D003500:Cyclization; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D013941:Thymine / Q000031:analogs & derivatives / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D014230:Triazoles; D003300:Copper; D004247:DNA; D013941:Thymine