Early predictors of adverse left ventricular remodelling after myocardial infarction treated by primary angioplasty.
BACKGROUND
Progressive left ventricular dilatation (PLVD) occurs after myocardial infarction (MI), and this may take place in the area of primary percutaneous coronary intervention (PCI). The factors predicting PLVD after primary PCI still need to be clarified. The aim of the study was to assess the prevalence and to define the baseline clinical and echocardiographic predictors of PLVD in patients with STEMI treated by primary PCI.


METHODS
Of the 90 patients initially selected for the study 88 (29 women and 59 men, mean age 67.1 +/- 5.6 years) with first ST-elevation myocardial infarction (STEMI) treated with primary PCI were examined. Echocardiographic examination was performed in all patients at discharge (M1) and after 6 months (M2). The following factors influencing PLVD were evaluated: type of infarct-related artery (IRA), infarct size expressed as wall motion score index (WMSI) >/= 1.5, left ventricular end-diastolic volume index (LVEDVI) >/= 80 ml/m(2), ejection fraction (EF) </= 45%, restrictive pattern of transmitral flow, time to reperfusion, left ventricular mass index (LVMI) >/= 125 g/m(2) and coronary risk factors.


RESULTS
The overall prevalence of PLVD (according to the criterion of 20% LVEDVI increase from M1 to M2) was 24%. Univariate regression analysis revealed that the following were the significant baseline M1 predictors of adverse PLVD: left anterior descending as IRA (relative risk: rr = 2.3, p < 0.05), WMSI >/= 1.5 (rr = 4.29, p < 0.005), EF </= 45% (rr = 2.89, p < 0.005) and a restrictive pattern of transmitral flow (rr = 2.4, p < 0.01). Multivariate logistic analysis showed that the only independent determinant of PLVD was WMSI >/= 1.5.


CONCLUSIONS
Both regional and global left ventricular systolic dysfunction indices as well as severe left ventricular diastolic abnormalities but not left ventricular dilatation at discharge are significant predictors of adverse cardiac remodelling after STEMI in patients treated with primary PCI. However the only independent determinant of PLVD was WMSI >/= 1.5 expressing the infarct size. (Cardiol J 2007; 14: 238-245).
Loboz-Grudzień
Krystyna
K
Kowalska
Alicja
A
Brzezińska
Barbara
B
Sokalski
Leszek
L
Jaroch
Joanna
J