Immunoglobulin kappa gene repertoire and somatic hypermutation patterns in follicular lymphoma.
Immunoglobulin kappa gene usage and somatic mutation patterns were studied in a series of 47 IGKV-J rearrangements amplified in 42 follicular lymphoma (FL) cases. The IGKV1-39/1D-39 gene predominated and was significantly over-represented compared to normal cells, autoreactive cells or other B cell lymphomas. The impact of somatic hypermutation varied significantly; nevertheless, mutation distribution patterns indicated pressure for preservation of the B cell receptor. In conclusion, the present series demonstrates biased usage of IGKV genes in FL and alludes to the important role of immunoglobulin kappa light chains in antigen selection of the clonogenic B cells in FL.
Smilevska
Tatjana
T
Hematology Department and Hematopoietic Cell Transplantation Unit, G. Papanicolaou Hospital, 57010 Asvestohori, Thessaloniki, Greece.
Tsakou
Eugenia
E
Hadzidimitriou
Anastasia
A
Bikos
Vasilis
V
Stavroyianni
Niki
N
Laoutaris
Nikolaos
N
Fassas
Alphathanasios
A
Alphanagnostopoulos
Achilles
A
Papadaki
Theodora
T
Belessi
Chrysoula
C
Stamatopoulos
Kostas
K
D001402:B-Lymphocytes / Q000276:immunology; D002999:Clone Cells; D015321:Gene Rearrangement; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D008224:Lymphoma, Follicular / Q000235:genetics* / Q000473:pathology; D011947:Receptors, Antigen, B-Cell / Q000235:genetics; D027041:Somatic Hypermutation, Immunoglobulin
D007145:Immunoglobulin kappa-Chains; D011947:Receptors, Antigen, B-Cell