Nanotube-assisted protein deactivation.
Conjugating proteins onto carbon nanotubes has numerous applications in biosensing, imaging and cellular delivery. However, remotely controlling the activity of proteins in these conjugates has never been demonstrated. Here we show that upon near-infrared irradiation, carbon nanotubes mediate the selective deactivation of proteins in situ by photochemical effects. We designed nanotube-peptide conjugates to selectively destroy the anthrax toxin, and also optically transparent coatings that can self-clean following either visible or near-infrared irradiation. Nanotube-assisted protein deactivation may be broadly applicable to the selective destruction of pathogens and cells, and will have applications ranging from antifouling coatings to functional proteomics.
Joshi
Amit
A
Punyani
Supriya
S
Bale
Shyam Sundhar
SS
Yang
Hoichang
H
Borca-Tasciuc
Theodorian
T
Kane
Ravi S
RS
D000942:Antigens, Bacterial / Q000737:chemistry* / Q000302:isolation & purification*; D001427:Bacterial Toxins / Q000737:chemistry* / Q000302:isolation & purification*; D001665:Binding Sites; D003666:Decontamination / Q000379:methods*; D036103:Nanotechnology / Q000379:methods; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000302:isolation & purification*
D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D037742:Nanotubes, Carbon; D011506:Proteins; C030325:anthrax toxin