[State-of-the-art immune genetic and immune biological aspects of rheumatoid arthritis].
One of the actual problems of clinical rheumatology was and remains the necessity of the earliest diagnostics of rheumatoid arthritis (RA) with the aim of adequate therapy for prevention of development of destructive changes, function ability loss and complication leading to reduction in patient's life quality, invalidization and lethal outcome. The predictors of the course of disease in its early stages, knowledge of its development mechanisms, are the base for optimal therapeutic influence on specific targets with the existing drugs and for development new ones. State-of-the-art data in genetic and immunological RA markers, whose detection in RA early stages helps to make RA diagnosis and to predict the disease course are represented. Immunological markers-antibodies to cyclic citrullinized peptide (aCCP) and rheumatoid factor (RF) have high specificity and sensitivity to RA diagnostics. Some alleles of the HLA-DRB1 locus coding shared epitope (SE) play the role of immune genetic factor predisposing to RA development and giving additional information for RA diagnostics in case of negative values of aCCP and RF.
Guseva
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Nasonov
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D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology*; D005006:Ethnicity / Q000235:genetics; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D044469:Racial Groups / Q000235:genetics
D006684:HLA-DR Antigens; D007074:Immunoglobulin G