Aldol reaction catalyzed by a hydrophilic catalyst in aqueous micelle as an enzyme mimic system.
Chitosan-supported L-proline complex was synthesized and applied as a catalyst for the direct asymmetric aldol reaction in various organic solvents and water as well. It was found that the novel synthesized catalyst was able to efficiently catalyze the aldol reaction in various media. The catalytic capacity and stereoselectivity of the catalyst were obviously improved with the introduction of aqueous micelle, possibly because the micelle functioned as a hydrophobic pocket, like the hydrophobic portion in enzymes. Moreover, the present synthetic catalyst showed performance similar to that of enzymes and could be used as a model of enzyme catalysis to help better understand the mystic mechanism of enzymes.
Zhang
Hefeng
H
College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475001, People's Republic of China.
Zhao
Wenshan
W
Zou
Jun
J
Liu
Yi
Y
Li
Runtao
R
Cui
Yuanchen
Y
D000447:Aldehydes / Q000737:chemistry*; D019149:Bioreactors; D002384:Catalysis; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D018716:Molecular Mimicry; D013696:Temperature; D014867:Water / Q000737:chemistry*
D000447:Aldehydes; D004798:Enzymes; D008823:Micelles; D014867:Water; C116609:3-hydroxybutanal