title: Study of bipathic effect of phenazepam.
abstract: Phenazepam in ultralow doses significantly potentiated anxiolytic and anticonvulsant effects of therapeutic doses of the same drug both after preliminary or simultaneous administration, which attests to bipathic action of phenazepam. The combination of ultralow and therapeutic doses of phenazepam prevented the development of its specific myorelaxant and sedative side effects.
authors.affiliation: Materia Medica Holding Research-and-Production Company, Moscow.
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
authors.forename: G M
authors.initials: GM
authors.lastname: Molodavkin
authors.forename: M V
authors.initials: MV
authors.lastname: Belopol'skaya
authors.forename: I A
authors.initials: IA
authors.lastname: Kheyfets
authors.forename: J L
authors.initials: JL
authors.lastname: Dugina
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011897:Random Allocation; D051381:Rats
chemical_list: D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; C017928:phenazepam