Molecular diagnosis of a benign proliferative nodule developing in a congenital melanocytic nevus in a 3-month-old infant.
Small and intermediate congenital melanocytic nevi have a lifetime risk of developing melanoma estimated to range from 0% to 5%. Secondary benign melanocytic proliferations commonly arise in congenital melanocytic nevi; however, some are difficult to definitively distinguish from malignant melanoma based on clinical features and conventional histology. Herein, we describe the use of comparative genomic hybridization in supporting the diagnosis of a deep penetrating nevus developing within a congenital melanocytic nevus of a 3-month-old infant.
Murphy
Michael J
MJ
Division of Dermatopathology, University of Connecticut School of Medicine, Farmington, Connecticut 06030, USA. drmichaelmurphy@netscape.net
Jen
Melinda
M
Chang
Mary Wu
MW
Grant-Kels
Jane M
JM
Makkar
Hanspaul
H
D049109:Cell Proliferation; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008544:Melanocytes / Q000473:pathology*; D009508:Nevus, Pigmented / Q000150:complications / Q000151:congenital* / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D009693:Nucleic Acid Hybridization / Q000379:methods; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology*
D019394:Ki-67 Antigen