DRD2 and ANKK1 genotype in alcohol-dependent patients with psychopathic traits: association and interaction study.
BACKGROUND
The TaqI-A polymorphism of the ANKK1 gene, adjacent to the DRD2 gene, has been associated with alcoholism and other psychiatric conditions, although other DRD2 gene variants, such as the C957T polymorphism, could be related to these phenotypic traits.


OBJECTIVE
To investigate the contribution of the TaqI-A and the C957T polymorphisms to the presence of psychopathic traits in patients with alcoholism.


METHODS
We performed association and interaction analyses of the polymorphisms in 150 controls and 176 male alcohol-dependent patients assessed for the presence of dissocial personal disorder, using the Psychopathy Checklist-Revised (PCL-R).


RESULTS
There was a significant association of the TaqI-A and C957T polymorphisms when both genotypes were present, with PCL-R scores of F(1-171=0.13) (P=0.01) and a frequency of dissocial personal disorder OR=10.52, P<0.001.


CONCLUSIONS
The TaqI-A of the ANKK1 gene and the C957T of the DRD2 gene are epistatically associated with psychopathic traits in alcohol-dependent patients.
Ponce
G
G
Servicio de Psiquiatría, Hospital 12 de Octubre, Madrid, Spain.
Hoenicka
J
J
Jiménez-Arriero
M A
MA
Rodríguez-Jiménez
R
R
Aragüés
M
M
Martín-Suñé
N
N
Huertas
E
E
Palomo
T
T
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000235:genetics* / Q000523:psychology; D000987:Antisocial Personality Disorder / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D013030:Spain; D013223:Statistics as Topic
D017448:Receptors, Dopamine D2; C489948:ANKK1 protein, human; D017346:Protein Serine-Threonine Kinases