title: Actin-binding channels.
abstract: Channel proteins play essential roles in physiology including ion and volume homeostasis and signal transduction and in pathophysiology of many human diseases. Recently, the importance of the actin cytoskeleton in the channel protein regulation has been highlighted. The actin cytoskeleton and its reorganization have been reported to be required for the regulation of both channel activity and its intracellular trafficking. Furthermore, there are increasing evidences showing the direct interactions of channel to actin. This review focuses on actin-binding channel proteins and the role of the actin interaction in the channel protein regulation.
authors.affiliation: Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Noda
authors.forename: Sei
authors.initials: S
authors.lastname: Sasaki
mesh_terms: D051399:Aquaporin 2 / Q000502:physiology; D002468:Cell Physiological Phenomena; D018118:Chloride Channels / Q000502:physiology; D003593:Cytoplasm / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology / Q000648:ultrastructure; D053503:Epithelial Sodium Channels / Q000187:drug effects / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007473:Ion Channels / Q000502:physiology*; D008840:Microfilament Proteins / Q000502:physiology*; D010010:Osteoclasts / Q000502:physiology; D015398:Signal Transduction; D012964:Sodium / Q000502:physiology; D014556:Urine / Q000502:physiology; D025262:Vacuolar Proton-Translocating ATPases / Q000378:metabolism; D050994:Voltage-Dependent Anion Channels / Q000502:physiology
chemical_list: C496023:AQP2 protein, human; D051399:Aquaporin 2; D018118:Chloride Channels; D053503:Epithelial Sodium Channels; D007473:Ion Channels; D008840:Microfilament Proteins; D050994:Voltage-Dependent Anion Channels; D012964:Sodium; D025262:Vacuolar Proton-Translocating ATPases