Ameliorative effect of curcumin on aflatoxin-induced toxicity in serum of mice.
The present investigation was an attempt to evaluate the ameliorative effect of curcumin on aflatoxin-induced toxicity on serum and blood of mice. Aflatoxin was obtained by growing Aspergillus parasiticus in SMKY liquid medium. Pure curcumin (97% purity) was purchased from Hi-Media Laboratories Pvt. Ltd., Mumbai, India. Young adult male albino mice were orally administered with low dose and high dose (750 and 1500 microg/kg body weight) with and without curcumin (2 mg/0.2 mL olive oil/animal/day) for 45 days. On 46th day the animals were sacrificed by cervical dislocation. For serum parameters blood was collected in non-EDTA containing vails from heart of the dissected mice. Serum parameters are creatinine, protein, AST and ALT. The results revealed dose dependent increase in creatinine, AST and ALT and decrease in protein in serum parameters of mice. Treatment with curcumin along with aflatoxin ameliorates aflatoxin-induced changes in serum parameters.
Mathuria
Neeta
N
Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad, India. mathuria_25@yahoo.co.in
Verma
Ramtej Jayram
RJ
D000348:Aflatoxins / Q000008:administration & dosage / Q000302:isolation & purification / Q000633:toxicity*; D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood / Q000187:drug effects; D001230:Aspergillus / Q000737:chemistry; D001798:Blood Proteins / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D003474:Curcumin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice
D000348:Aflatoxins; D000975:Antioxidants; D001798:Blood Proteins; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003474:Curcumin