title: Bone repair process in calvarial defects using bioactive glass and calcium sulfate barrier.
abstract: OBJECTIVE
  To analyze bone repair process in Wistar rats' calvaria, with the use of two different biomaterials.
  
  
  METHODS
  Forty two male Wistar rats were used, and four bicortical cranial cavities were created in each animal. The cavities were filled with: bioactive glass (BG); calcium sulfate barrier (CSB); bioactive glass covered with calcium sulfate barrier (BG/CSB); and autogenous blood clot (control). The animals were euthanized 7, 14, 21, 30, 60, 90, e 120 days after surgery. The scalps were removed and submitted to a routine process for histological preparation: staining with Haematoxylin and Eosin (HE).
  
  
  RESULTS
  The BG was not completely resorbed; however, after 60 days, a decrease in size as well as a change in the morphological granule were observed. CSB was not observed in the last group (after 120 days).
  
  
  CONCLUSIONS
  In Wistar rat calvaria bioactive glass, in an isolated form, negatively interfered in the bone repair process; the calcium sulfate barrier, in an isolated form, presented the capacity to maintain space, allowing the flow of osteogenic cells; the bioactive glass covered with calcium sulfate barrier association presented a better osteoconductive capacity when compared to isolated materials; calcium sulfate barrier was completely resorbed after 90 days; control cavities did not completely heal until 120 days after surgery.
authors.affiliation: Department of Oral and Maxillofacial Surgery and Traumatology, Faculty of Dentistry of Porto Alegre, PUC-RS, Porto Alegre, Brazil. rogerlanes@yahoo.com.br
authors.forename: Roger Lanes
authors.initials: RL
authors.lastname: Silveira
authors.forename: Rosilene Andréa
authors.initials: RA
authors.lastname: Machado
authors.forename: Carla Roberta de Siqueira
authors.initials: CR
authors.lastname: Silveira
authors.forename: Rogério Belle
authors.initials: RB
authors.lastname: Oliveira
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002133:Calcium Sulfate / Q000627:therapeutic use*; D002516:Ceramics; D008297:Male; D008422:Materials Testing; D010012:Osteogenesis / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012886:Skull / Q000166:cytology / Q000502:physiology / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; C022107:Bioglass; D018786:Bone Substitutes; D002133:Calcium Sulfate