title: Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma.
abstract: Five percent of 145 HIV-1 infected men enrolled in an assisted reproductive technology (ART) program harbored detectable HIV-1 RNA in semen, although they had no other sexually transmitted disease and their blood viral load was undetectable for at least 6 months under antiretroviral treatment. This result justifies measuring HIV-1 RNA in semen before the ART process and suggests that a residual risk of transmission has to be mentioned to the patients who would like to have unprotected sexual intercourse.
authors.affiliation: UPMC Univ Paris 06, EA 2387, Paris, France. anne-genevieve.marcelin@psl.aphp.fr
authors.forename: Anne-Geneviève
authors.initials: AG
authors.lastname: Marcelin
authors.forename: Roland
authors.initials: R
authors.lastname: Tubiana
authors.forename: Sidonie
authors.initials: S
authors.lastname: Lambert-Niclot
authors.forename: Gilles
authors.initials: G
authors.lastname: Lefebvre
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Dominguez
authors.forename: Manuela
authors.initials: M
authors.lastname: Bonmarchand
authors.forename: Daniele
authors.initials: D
authors.lastname: Vauthier-Brouzes
authors.forename: Françoise
authors.initials: F
authors.lastname: Marguet
authors.forename: Nathalie
authors.initials: N
authors.lastname: Mousset-Simeon
authors.forename: Gilles
authors.initials: G
authors.lastname: Peytavin
authors.forename: Catherine
authors.initials: C
authors.lastname: Poirot
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000821:virology; D012367:RNA, Viral / Q000032:analysis* / Q000097:blood; D027724:Reproductive Techniques, Assisted; D012306:Risk; D012661:Semen / Q000821:virology*; D019562:Viral Load / Q000379:methods
chemical_list: D044966:Anti-Retroviral Agents; D012367:RNA, Viral