Hormonal status modifies renin-angiotensin system-regulating aminopeptidases and vasopressin-degrading activity in the hypothalamus-pituitary-adrenal axis of female mice.
The hypothalamus-pituitary-adrenal axis (HPA) participates in the maintenance of cardiovascular functions and in the control of blood pressure. By other hand, it is known that blood pressure regulation and HPA activity are affected by sex hormones. The aim of the present work is to analyze the influence of estradiol and progesterone on renin-angiotensin system (RAS)-regulating aminopeptidase A, aminopeptidase B and aminopeptidase N activities and vasopressin-degrading activity in the HPA axis of ovariectomized mice and ovariectomized mice treated subscutaneously with different doses of estradiol and progesterone. Our data suggest that in female mice, estradiol and progesterone influence RAS-regulating and vasopressin-degrading activities at different levels of the HPA axis.
García
María Jesús
MJ
Department of Health Sciences, Physiology, Faculty of Experimental and Health Sciences, University of Jaén, Campus Universitario Las Lagunillas, Jaén, Spain.
Martínez-Martos
José Manuel
JM
Mayas
María Dolores
MD
Carrera
María Pilar
MP
De la Chica
Susana
S
Cortés
Pedro
P
Ramírez-Expósito
María Jesús
MJ
D000626:Aminopeptidases / Q000378:metabolism*; D000818:Animals; D005260:Female; D007031:Hypothalamus / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D012084:Renin-Angiotensin System; D012995:Solubility; D013379:Substrate Specificity; D014667:Vasopressins / Q000378:metabolism*
D014667:Vasopressins; D000626:Aminopeptidases