title: Wavefront-guided laser in situ keratomileusis in the treatment of high myopia by using the CustomVue wavefront platform.
abstract: OBJECTIVE
  To assess the efficacy, predictability, and safety of wavefront-guided laser in situ keratomileusis (LASIK) in the treatment of high myopia by using the Visx S4 CustomVue wavefront platform.
  
  
  METHODS
  A retrospective analysis of consecutive cases of eyes with high myopia (manifest refraction spherical equivalent >or= -6.00 D) that underwent non-physician-adjusted wavefront-guided LASIK by using the Visx S4 CustomVue wavefront platform. Forty-three eyes of 29 patients were included. Preoperative best spectacle-corrected visual acuity (BSCVA), manifest refraction, WaveScan refraction, postoperative uncorrected visual acuity (UCVA) and BSCVA, and manifest refraction were determined. The clinical outcomes were evaluated on the basis of standard formats and criteria. Data at 3 months postoperatively are presented.
  
  
  RESULTS
  Preoperatively, we found mean sphere was -6.89 +/- 1.08 D, mean cylinder was -0.97 +/- 0.75 D, and mean spherical equivalent (SE) was -7.38 +/- 1.20 D. Postoperatively, mean sphere was 0.02 +/- 0.40 D, mean cylinder was -0.40 +/- 0.40 D, and mean SE was -0.18 +/- 0.43 D. UCVA was 20/15 or better in 27.9% and cumulatively 20/20 or better in 58% of eyes. All eyes treated had at least 20/50 UCVA. Efficacy index was 0.94. Eighty-two percent of eyes were within 0.50 D and 97.6% were within 1.00 D of emmetropia at the 3-month follow-up visit. Ninety-one percent of eyes either maintained or gained 1 line of BSCVA. No eye lost >1 line of BSCVA. The safety index was 1.1.
  
  
  CONCLUSIONS
  The 3-month follow-up results of our study indicate that wavefront-guided LASIK by using the Visx S4 CustomVue wavefront platform is an effective, predictable, and safe treatment of high myopia.
authors.affiliation: Shiley Eye Center, University of California, San Diego, La Jolla, CA 92093-0946, USA.
authors.forename: Tharinee
authors.initials: T
authors.lastname: Kulkamthorn
authors.forename: John Nathaniel I
authors.initials: JN
authors.lastname: Silao
authors.forename: Luis F
authors.initials: LF
authors.lastname: Torres
authors.forename: Janice N
authors.initials: JN
authors.lastname: Lim
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Purcell
authors.forename: Theeratep
authors.initials: T
authors.lastname: Tantayakom
authors.forename: David J
authors.initials: DJ
authors.lastname: Schanzlin
mesh_terms: D000328:Adult; D003319:Corneal Stroma / Q000601:surgery*; D019781:Corneal Topography / Q000379:methods*; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000379:methods*; D054018:Lasers, Excimer / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000601:surgery*; D012029:Refraction, Ocular / Q000502:physiology; D012189:Retrospective Studies; D013524:Surgical Flaps; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology