Antiepileptic drugs and thyroid function.
Antiepileptic drugs (AED) are a heterogeneous group of compounds widely used in both adults and children. These drugs are related to various adverse effects involving several organs and endocrinological and metabolic functions. In particular, relevant effects on thyroid function have been described. Subclinical hypothyroidism and alterations in thyroid hormone serum levels are reported in the literature; phenytoin, valproate and carbamazepine, in particular, seem to be involved in these alterations. The aim of this review is to analyse critically the principal alterations in thyroid function caused by AED therapy.
Verrotti
Alberto
A
Department of Pediatrics, University of Chieti, Chieti, Italy.
Scardapane
Alessandra
A
Manco
Rossella
R
Chiarelli
Francesco
F
D000927:Anticonvulsants / Q000009:adverse effects* / Q000494:pharmacology; D002220:Carbamazepine / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D010672:Phenytoin / Q000009:adverse effects / Q000494:pharmacology; D013961:Thyroid Gland / Q000187:drug effects* / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000097:blood; D014635:Valproic Acid / Q000009:adverse effects / Q000494:pharmacology
D000927:Anticonvulsants; D013963:Thyroid Hormones; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin