Clozapine or Haloperidol in rats prenatally exposed to methylazoxymethanol, a compound inducing entorhinal-hippocampal deficits, alter brain and blood neurotrophins' concentrations.
Rats exposed during prenatal life to methylazoxymethanol (MAM) display in postnatal age structural and behavioral deficits resembling those observed in schizophrenic patients. These deficits are associated with significant changes in brain nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), particularly in the hippocampus and entorhinal cortex. In the present study, we used the MAM model to investigate in young rats the effect of antipsychotics, Clozapine and Haloperidol, on brain and blood NGF and BDNF presence. Young animals were used because administration of antipsychotics during adolescence is a common feature of intervention. The results showed that administration of Clozapine and Haloperidol causes significant changes in the concentration of NGF and BDNF in the brain and bloodstream of MAM-treated rats. These findings indicate that these drugs may affect the synthesis and release of neurotrophins in the central nervous system and in the blood circulation. In addition, the MAM model can be a useful tool to investigate the biochemical and molecular mechanisms regarding the effects of antipsychotics.
Fiore
Marco
M
Istituto di Neurobiologia e Medicina Molecolare, Sezione NGF, Consiglio Nazionale delle Ricerche, Rome, Italy.
Di Fausto
Veronica
V
Iannitelli
Angela
A
Aloe
Luigi
L
D000477:Alkylating Agents; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D003024:Clozapine / Q000494:pharmacology*; D018728:Entorhinal Cortex / Q000002:abnormalities / Q000473:pathology*; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology*; D006624:Hippocampus / Q000002:abnormalities / Q000473:pathology*; D008746:Methylazoxymethanol Acetate / Q000031:analogs & derivatives*; D009414:Nerve Growth Factors / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D000477:Alkylating Agents; D014150:Antipsychotic Agents; D009414:Nerve Growth Factors; D008746:Methylazoxymethanol Acetate; D003024:Clozapine; D006220:Haloperidol; C030667:methylazoxymethanol