title: The effects of the polymorphism in exon 3 of the FAS gene on the death of chicken embryos during the incubation period.
abstract: To investigate the effect of a factor-associated suicide (FAS) gene polymorphism on the death of chicken embryos, we genotyped 190 dead embryos and 69 normally developing embryos from 7200 hatching Short-Leg Yellow Chicken eggs, as well as 119 dead embryos and 69 normally developing embryos from 4650 hatching Yellow B Chicken eggs. The results showed that there were significant (P < 0.05) genotypic differences between dead and normally developing embryos for this FAS gene polymorphism, a SNP in exon 3 (NC_006093.2:g.6514A>C, rs15793179). Logistic regression revealed that Short-Leg Yellow Chicken embryos with genotype g.6514CC had a significantly (P < 0.01) higher risk of death than those with genotype g.6514AC. This polymorphism has the potential to be an effective tool when used in conjunction with traditional selection methods.
authors.affiliation: Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.
authors.forename: J J
authors.initials: JJ
authors.lastname: Wu
authors.forename: W M
authors.initials: WM
authors.lastname: Li
authors.forename: R X
authors.initials: RX
authors.lastname: Zhao
authors.forename: J
authors.initials: J
authors.lastname: Fang
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: X L
authors.initials: XL
authors.lastname: Peng
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: J J
authors.initials: JJ
authors.lastname: Xiong
authors.forename: L G
authors.initials: LG
authors.lastname: Yang
authors.forename: S J
authors.initials: SJ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D030161:Avian Proteins / Q000235:genetics*; D002642:Chick Embryo; D002645:Chickens / Q000235:genetics*; D003433:Crosses, Genetic; D005091:Exons; D053222:Fas Ligand Protein / Q000235:genetics*; D005260:Female; D005804:Genes, Lethal; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D030161:Avian Proteins; D053222:Fas Ligand Protein