title: Tubulointerstitial nephritis and uveitis (TINU) syndrome caused by the Chinese herb "Goreisan".
abstract: A 58-year-old man was admitted to our hospital complaining of fever and arthralgia. His clinical course and marked ciliary hyperemia led us to suspect tubulointestinal nephritis and uveitis (TINU) syndrome, which was confirmed ophthalmologically and by renal biopsy. Results of a drug-induced lymphocyte-stimulating test were positive for the Chinese herb "Goreisan." This is the first case in which the use of "Goreisan" was causally related to TINU syndrome.
authors.affiliation: Department of Internal Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-Hondori, Miyakojima, Osaka, Japan. hisa406coupe@yahoo.co.jp
authors.forename: Hisa
authors.initials: H
authors.lastname: Suzuki
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Masato
authors.initials: M
authors.lastname: Miyano
authors.forename: Isseki
authors.initials: I
authors.lastname: Maeda
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamagami
authors.forename: Takashi
authors.initials: T
authors.lastname: Morikawa
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Okada
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Konishi
authors.forename: Masahito
authors.initials: M
authors.lastname: Imanishi
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018771:Arthralgia / Q000139:chemically induced; D001706:Biopsy; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005334:Fever / Q000139:chemically induced; D005451:Fluorescein Angiography; D006801:Humans; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000473:pathology; D008297:Male; D020835:Medicine, Kampo; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D013577:Syndrome; D014605:Uveitis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D001613:beta 2-Microglobulin; C111129:gorei-san