title: [Effects of zingerone on fat storage in ovariectomized rats].
abstract: We reported that ginger prevented obesity in mice fed a high-fat diet in previous study. In this experiment, we examined the effects of zingerone, the major pungent component of ginger on fat storage in ovariectomized (Ovx) rats. Oral administration of 170 mg/kg zingerone significantly reduced body weight and the final parametrail adipose tissue weight in ovariectomized rats. Blood glucose levels after oral administration of glucose were lower in zingerone-treated Ovx-rats than in the Ovx-rats (control). Basal lipolysis in zingerone-treated Ovx-rats was increased compared with that in the Ovx-rats. Zingerone significantly increased norepinephrine-induced lipolysis associated with the translocation of hormone-sensitive lipase (HSL) from the cytosol to lipid droplets in adipocytes. These results indicate that zingerone may prevent the fat storage through increasing norepinephrine-induced lipolysis in adipocytes.
authors.affiliation: R&D Laboratory, Kracie Holdings Ltd, Tokyo, Japan. r.han@khp.kracie.co.jp
authors.forename: Li-Kun
authors.initials: LK
authors.lastname: Han
authors.forename: Chie
authors.initials: C
authors.lastname: Morimoto
authors.forename: Yi-Nan
authors.initials: YN
authors.lastname: Zheng
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Etsuko
authors.initials: E
authors.lastname: Asami
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Okuda
authors.forename: Masato
authors.initials: M
authors.lastname: Saito
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects*; D008066:Lipolysis / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D002787:Sterol Esterase / Q000378:metabolism
chemical_list: D001786:Blood Glucose; C013738:zingerone; D006139:Guaiacol; D002787:Sterol Esterase; D009638:Norepinephrine