title: Asymmetric addition of phenylacetylene to aromatic ketones catalyzed by zinc or titanium complexes with chiral hydroxysulfonamide.
abstract: Various new chiral hydroxysulfonamide ligands (3a-3n, 4a-4d) were prepared. Compounds 3a, 3g, 3i, 3k-3n, 4a-4d could accelerate the reaction and reduce reaction time, and 3a, 3g, 3i, 3k-3n catalyzed the reaction without titanium. The results obtained were promising in terms of yields and enantiomeric excesses (3k up to 85% ee, 4a up to 83% ee).
authors.affiliation: College of Life Sciences, China Jiliang University, Hangzhou, China.
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Zhou
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Han
authors.forename: Li
authors.initials: L
authors.lastname: Qiu
authors.forename: Jin-Yan
authors.initials: JY
authors.lastname: Liang
authors.forename: Feng-Bo
authors.initials: FB
authors.lastname: Ren
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000098:Acetophenones / Q000737:chemistry; D000114:Acetylene / Q000031:analogs & derivatives* / Q000494:pharmacology; D000438:Alcohols / Q000737:chemistry; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D007659:Ketones / Q000378:metabolism*; D008024:Ligands; D008956:Models, Chemical; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D000098:Acetophenones; D000438:Alcohols; D007659:Ketones; D008024:Ligands; D013449:Sulfonamides; C044736:phenylacetylene; D014025:Titanium; D015032:Zinc; D000114:Acetylene; C038699:acetophenone