title: Effect and tolerability of felodipine ER (Feloten) in the treatment of hypertension assessed by office blood pressure and home blood pressure.
abstract: OBJECTIVE
  To assess the efficacy of once daily dose generic Felodipine ER, Feloten in terms of BP lowering as assessed by office BP measurement (OBPM) and Home BP monitoring (HBPM) MATERIAL AND METHOD: Mild and moderate hypertensive patients (n = 60) were enrolled by primary care physicians. After a 2 week run-in phase in which all patients received placebo, subjects received generic felodipine ER 5 mg for 3 weeks. After 3 weeks of treatment, patients whose blood pressure target was not achieved were given 10 mg of felodipine ER for 3 weeks. OBPM and HBPM were performed in the morning, noon, evening, and nighttime for 1 day at baseline, 3 weeks, and 6 weeks.
  
  
  RESULTS
  After 6 weeks, Generic felodipine ER reduced the average systolic BP (SBP) and diastolic BP (DBP) measured by OBPM and HBPM. The effect on SBP showed every time on HBPM and was more pronounced in the morning (trough drug level). However, the effects on DBP were not significant in the morning and noon. No serious adverse drug side effect was detected
  
  
  CONCLUSIONS
  Generic felodipine ER is effective in SBP reduction, in both OBPM and HBPM. It can be used once daily to control the blood pressure for 24 hours.
authors.affiliation: Department of Medicine, Buddhachinaraj Hospital, Phitsanulok, Thailand. ttomon@hotmail.com
authors.forename: Tomon
authors.initials: T
authors.lastname: Thongsri
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D002986:Clinical Trials as Topic; D003971:Diastole; D015736:Felodipine / Q000627:therapeutic use*; D005260:Female; D006699:Home Care Services; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009819:Office Visits; D012647:Self-Assessment; D016037:Single-Blind Method; D013599:Systole
chemical_list: D000959:Antihypertensive Agents; D015736:Felodipine