title: L-myc polymorphism in head and neck nonmelanoma skin and lower lip cancers.
abstract: OBJECTIVE
  To evaluate the presence of L-myc gene variations as a genetic predisposition to head and neck nonmelanoma skin cancer (HNNMSC) and lower lip cancer (LLC).
  
  
  METHODS
  A case-control study.
  
  
  METHODS
  An academic institute laboratory.
  
  
  METHODS
  Twenty-four patients with HNNMSC and 27 with LLC were compared with 51 age- and sex-matched control subjects.
  
  
  METHODS
  Polymerase chain reaction restriction fragment length polymorphism and agarose gel electrophoresis were used to determine the L-myc oncogene genotypes.
  
  
  RESULTS
  The presence of the LS genotype was found to be significantly increased in the study group, whereas the LL genotype was not detected. The S allele was also more frequent in the study group. The SS genotype was found to correlate with aggressive tumor behavior in patients with HNNMSC and a family history of cancer. Patients with LLC displayed significantly less of the SS genotype.
  
  
  CONCLUSIONS
  The L-myc gene polymorphism may help detect and prevent HNNMSC and LLC in susceptible individuals. It may also contribute to estimation of tumor behavior in patients with HNNMSC.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Vakif Gureba Research and Education Hospital, Istanbul, Turkey. aydinseye@yahoo.com
authors.forename: Aydin
authors.initials: A
authors.lastname: Gözü
authors.forename: Arzu
authors.initials: A
authors.lastname: Ergen
authors.forename: Deniz
authors.initials: D
authors.lastname: Dayicioglu
authors.forename: Ilhan
authors.initials: I
authors.lastname: Yaylim
authors.forename: Zafer
authors.initials: Z
authors.lastname: Ozsoy
authors.forename: Turgay
authors.initials: T
authors.lastname: Isbir
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002280:Basal Cell Carcinoma / Q000235:genetics* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D016259:Genes, myc / Q000235:genetics*; D006580:Genetic Carrier Screening; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000473:pathology; D006720:Homozygote; D006801:Humans; D008048:Lip Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics*; D011379:Prognosis; D012016:Reference Values; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology