Prenylated dihydrochalcones from Boronia bipinnata that inhibit the malarial parasite enzyme target hemoglobinase II.
High-throughput screening of a plant and marine invertebrate extract library to find natural products that inhibit the malarial parasite enzyme target hemoglobinase II led to the isolation of two new active prenylated chalcones, bipinnatones A (1) and B (2), from aerial parts of the Queensland shrub Boronia bipinnata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 inhibited hemoglobinase II with IC 50 values of 64 and 52 microM, respectively.
Carroll
Anthony R
AR
Eskitis Institute, Griffith University, Brisbane, Queensland, Australia 4111.
Fechner
Gregory A
GA
Smith
Jill
J
Guymer
Gordon P
GP
Quinn
Ronald J
RJ
D000818:Animals; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000201:enzymology*; D054876:Prenylation; D027821:Rutaceae / Q000737:chemistry*; D013057:Spectrum Analysis
D047188:Chalcones; D004791:Enzyme Inhibitors; C015812:dihydrochalcone