Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia.
A new chromosome-carried quinolone resistance gene from Stenotrophomonas maltophilia, Smqnr, was characterized. The gene was present in type strain CCUG 5866 and was also detected in 24 clinical isolates and showed some allelic diversity. The expression of Smqnr in Escherichia coli decreased the susceptibilities of the E. coli isolates to several fluoroquinolones.
Shimizu
Kenichiro
K
Department of Infection Control Science, Faculty of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8421, Japan.
Kikuchi
Ken
K
Sasaki
Takashi
T
Takahashi
Namiko
N
Ohtsuka
Masayuki
M
Ono
Yuka
Y
Hiramatsu
Keiichi
K
D000483:Alleles; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D002876:Chromosomes, Bacterial / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D024841:Fluoroquinolones / Q000494:pharmacology*; D005798:Genes, Bacterial; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D020615:Stenotrophomonas maltophilia / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D017931:DNA Primers; D004269:DNA, Bacterial; D024841:Fluoroquinolones