[The effect of X-rays and artificial hypotermia on lipids in rat neocortex].
Lipid content of tissue and of fraction of microsomes in neocortex of Wistar rats was studies under artificial hypothermia, after X-ray irradiation in dose 8 Gy under conditions of normothermia and artificial hypothermia in 48 h. The condition of artificial hypothermia get by cooling of rats to 15-18 degrees C. It was shown, that in fraction of microsomes of hypothermia rats the content of phosphatidylinositol was decreased, and in 48 h after cooling of rats the amount of protein, total and individual phospholipids was increased. The lipid content in tissue and in fraction of microsomes of rats, which were irradiated in normotermia, had no changes after 48 h. In fraction of microsomes of rats, which were irradiated after hypothermia, the amount of protein, total phospholipids, sphingomyelin, phosphatidylcholine and phosphatidylserine is increased trustworthy. Thus, we think, that radioprotective effect of hypotermia may be connected with the accumulation of proteins and of phospholipids in the endoplasmic reticulum membranes of neocortex.
Perepelkina
N I
NI
Markevich
L N
LN
Ignat'ev
D A
DA
Fialkovskaia
L A
LA
Kolomiĭtseva
I K
IK
D000818:Animals; D007036:Hypothermia, Induced; D050356:Lipid Metabolism / Q000528:radiation effects*; D008297:Male; D008861:Microsomes / Q000378:metabolism; D019579:Neocortex / Q000378:metabolism / Q000528:radiation effects*; D010716:Phosphatidylinositols / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011836:Radiation Tolerance / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014965:X-Rays
D010716:Phosphatidylinositols; D010743:Phospholipids