title: [Late mediastinal metastasis of Ewing's sarcoma of tibia].
abstract: Peripheral neuroectodermal tumors constitute a large spectrum of small round cell tumors among which Ewing's sarcoma is the most undifferentiated type. They are rare tumors which often concern young people and generally occur in bone tissue. Their metastatic potential is high, generally early, and rarely after five years. We report the case of a 45-year-old woman who presented a mediastinal metastasis eight years after the primitive tumor of tibia. The diagnosis was made on small core biopsies obtained by CT punction, and was based on morphologic analysis, immunohistochemistry, and confirmed by molecular biology. The presence of metastasis is the main prognostic factor. Despite therapeutic progress, the global survival rate of metastatic patients is still poor.
authors.affiliation: Service d'anatomie et de cytologie pathologiques, hôpital d'instruction des armées Percy, 92141 Clamart cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Cremades
authors.forename: C
authors.initials: C
authors.lastname: Tériitéhau
authors.forename: B
authors.initials: B
authors.lastname: Grand
authors.forename: P
authors.initials: P
authors.lastname: Saint-Blancard
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D011379:Prognosis; D011859:Radiography; D012512:Sarcoma, Ewing / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D013977:Tibia