title: Simulation of relative temporal resolution of time-resolved MRA sequences.
abstract: Time-resolved MRA sequences are typically characterized by the display frame rate. However, true temporal resolution should be defined in a manner analogous to spatial resolution; it is not the ability of a sequence to update rapidly but rather the ability to discern changes that occur within a small time that should characterize temporal resolution. For view-shared methods like Keyhole and time-resolved imaging of contrast kinetics (TRICKS), regions of k-space from multiple time frames are combined to form a single reconstructed time frame. This often causes the time needed to acquire all k-space data points to be significantly longer than the displayed frame time, resulting in a poor frequency response. Simulated here are the temporal impulse response and temporal frequency response (TFR) curves of three time-resolved MRA methods, including the recently introduced highly-constrained backprojection local reconstruction (HYPR LR) method. It is found that the HYPR LR reconstruction method exhibits a better TFR for a larger spectrum of temporal and spatial frequencies than the Keyhole and TRICKS methods.
authors.affiliation: Department of Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA. keith@wisc.edu
authors.forename: L
authors.initials: L
authors.lastname: Keith
authors.forename: S
authors.initials: S
authors.lastname: Kecskemeti
authors.forename: J
authors.initials: J
authors.lastname: Velikina
authors.forename: C
authors.initials: C
authors.lastname: Mistretta
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008955:Models, Cardiovascular; D008959:Models, Neurological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity