title: Delineation of the middle longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study.
abstract: Experimental and imaging studies in monkeys have outlined various long association fiber bundles within the temporoparietal region. In the present study the trajectory of the middle longitudinal fascicle (MdLF) has been delineated in 4 human subjects using diffusion tensor magnetic resonance imaging segmentation and tractography. The MdLF seems to extend from the inferior parietal lobule (IPL), specifically the angular gyrus, to the temporal pole remaining within the white matter of the superior temporal gyrus (STG). Comparison of the superior longitudinal fascicle II-arcuate fascicle (SLF II-AF) with the MdLF in the same subjects revealed that MdLF is located in a medial and caudal position relative to SLF II-AF and that it extends more rostrally. Given the location of MdLF between the IPL (angular gyrus) and the STG, it is suggested that MdLF could have a role in language and attention functions.
authors.affiliation: Harvard Medical School Department of Psychiatry, Center for Morphometric Analysis, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, 02129, USA. nikos@cma.mgh.harvard.edu
authors.forename: Nikos
authors.initials: N
authors.lastname: Makris
authors.forename: George M
authors.initials: GM
authors.lastname: Papadimitriou
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Kaiser
authors.forename: Scott
authors.initials: S
authors.lastname: Sorg
authors.forename: David N
authors.initials: DN
authors.lastname: Kennedy
authors.forename: Deepak N
authors.initials: DN
authors.lastname: Pandya
mesh_terms: D000328:Adult; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology*; D010296:Parietal Lobe / Q000033:anatomy & histology / Q000502:physiology; D013702:Temporal Lobe / Q000033:anatomy & histology / Q000502:physiology; D055815:Young Adult