Initial human herpesvirus-8 rash and multicentric Castleman disease.
We describe a human immunodeficiency virus-infected man with relapsing rashes and reactivation of human herpesvirus-8 (HHV-8) infection, which evolved into multicentric Castleman disease. Initial skin biopsy revealed infiltrating HHV-8-positive plasmablasts, a subset of which supported lytic infection. We document the first case, to our knowledge, of HHV-8-induced rash and suggest that circulating plasmablasts drive HHV-8 to target tissues.
Wyplosz
Benjamin
B
Unité des Maladies Infectieuses et Tropicales, Hôpital Paul Brousse, Villejuif, Paris, France. benjamin.wyplosz@pbr.aphp.fr
Carlotti
Agnès
A
Escaut
Lélia
L
Vignier
Nicolas
N
Guettier
Catherine
C
Agbalika
Félix
F
Vittecoq
Daniel
D
Dupin
Nicolas
N
D000368:Aged; D005871:Castleman Disease / Q000209:etiology*; D005076:Exanthema / Q000209:etiology*; D006566:Herpesviridae Infections / Q000150:complications* / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D010950:Plasma Cells / Q000821:virology; D012867:Skin / Q000473:pathology