Role of microRNAs in diabetes.
Diabetes is one of the most common chronic diseases in the world. Multiple and complex factors including various genetic and physiological changes can lead to type 1 and type 2 diabetes. However, the major mechanisms underlying the pathogenesis of diabetes remain obscure. With the recent discovery of microRNAs (miRNAs), these small ribonucleotides have been implicated as new players in the pathogenesis of diabetes and diabetes-associated complications. MiRNAs have been shown to regulate insulin production, insulin secretion, and insulin action. This review summarizes the recent progress in the cutting-edge research of miRNAs involved in diabetes and diabetes related complications.
Tang
Xiaoqing
X
Department of Molecular and Cellular Biochemistry, University of Kentucky, College of Medicine, 741 South Limestone, Lexington, KY 40536, USA. xiaoqing.tang@uky.edu
Tang
Guiliang
G
Ozcan
Sabire
S
D000818:Animals; D048909:Diabetes Complications / Q000235:genetics; D003920:Diabetes Mellitus / Q000235:genetics*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics*
D007328:Insulin; D035683:MicroRNAs