[Somatic maturation and sensorimotor development of C57BL/6 mice prenatally exposed to cytosine arabinoside].
The topical problem of experimental neurobiology is the development of pharmacological models to search for correlation between induced brain pathology and changes in behavioral phenotype. Cytosine arabinoside (Ara-c) is an antiproliferative agent, exposure to which in the critical period of the embryonic formation of the cortex results in the abnormality of its development. This study was aimed at estimation of the somatic and sensorimotor aspects of the early postnatal maturatrion of behavioral acts in mice with developmental abnormalities of the cortex induced by Ara-c. Pregnant C57BL/6 mice were injected with the substance on the 12.5th 13.5th gestation days. Offspring behavior was studied using a modified Fox battery on the 1st-21st postnatal days. Severe disorders of the sensorimotor development with slight somatic changes were revealed in the offsprings of Ara-c-treated mice. Features of these pathological changes point to a correlation between the developmental changes in behavioral phenotype and irregularities of the cortex formation. This experimental model can be applied to neurobiological and pharmacological studies.
Lobanov
A V
AV
Khokhlova
O N
ON
Zaraĭskaia
I Iu
IIu
Murashev
A N
AN
D000818:Animals; D000831:Animals, Newborn; D000970:Antineoplastic Agents / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects*; D003561:Cytarabine / Q000633:toxicity*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D009044:Motor Cortex / Q000187:drug effects* / Q000196:embryology / Q000473:pathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000187:drug effects; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000196:embryology / Q000473:pathology
D000970:Antineoplastic Agents; D003561:Cytarabine