title: A synthetic method for peptide-PEG-lipid conjugates: application of octreotide-PEG-DSPE synthesis.
abstract: A solid phase synthesis method was established for the synthesis of peptide-poly(ethylene glycol)-lipid (peptide-PEG-lipid) conjugates. Octreotide-PEG(2000)-DSPE (OPD(2000)) was used as an example to demonstrate the synthetic approach. The OPD(2000) obtained had confirmed structure, activity, and purity providing a targeting molecule for preparation of well-defined drug delivery systems, such as targeted liposomes, for further studies.
authors.affiliation: Department of Medical Research, Kuang Tien General Hospital, 5-2, Datong Street, Shalu, Taichung 43353, Taiwan, ROC.
authors.forename: Jian-Chiou
authors.initials: JC
authors.lastname: Su
authors.forename: Chin-Lu
authors.initials: CL
authors.lastname: Tseng
authors.forename: Ting-Gung
authors.initials: TG
authors.lastname: Chang
authors.forename: Wen-Jen
authors.initials: WJ
authors.lastname: Yu
authors.forename: Shih-Kwang
authors.initials: SK
authors.lastname: Wu
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D002845:Chromatography / Q000379:methods; D016503:Drug Delivery Systems; D007700:Kinetics; D008024:Ligands; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008968:Molecular Conformation; D015282:Octreotide / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D008024:Ligands; D008055:Lipids; D008081:Liposomes; D010455:Peptides; D010714:Phosphatidylethanolamines; C107570:polyethylene glycol-distearoylphosphatidylethanolamine; D011092:Polyethylene Glycols; D015282:Octreotide