title: SUMO4 gene polymorphisms in Chinese Han patients with Behcet's disease.
abstract: Small ubiquitin-like modifier 4 (SUMO4) has been shown to have the potential to down-regulate NF-kappaB signal, leading to decreased transcription of pro-inflammatory cytokines. Recently, SUMO4 polymorphisms have been shown to be associated with several autoimmune diseases. In the present study, the association of SUMO4 polymorphisms with Behcet's disease (BD) was investigated. Our results showed a significantly increased frequency of the + 438 C allele and a significantly decreased frequency of the AGAT haplotype in BD patients (p=0.0002, corrected p=0.002; p=0.000015, corrected p=0.0002, respectively). Stratification analysis indicated that these significant associations only existed in the HLA-B51 negative subjects (p=0.004, corrected p=0.032; p=0.001, corrected p=0.016, respectively). The GGAC haplotype was negatively associated with HLA-B51 positive BD patients (p=0.0007, corrected p=0.011). In conclusion, SUMO4 +438 C allele is associated with susceptibility to BD in HLA-B51 negative patients, while the AGAT haplotype is protectively associated with BD in HLA-B51 negative patients. The GGAC haplotype is protectively associated with BD in HLA-B51 positive patients.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, PR China.
authors.forename: Shengping
authors.initials: S
authors.lastname: Hou
authors.forename: Peizeng
authors.initials: P
authors.lastname: Yang
authors.forename: Liping
authors.initials: L
authors.lastname: Du
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhou
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Lin
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Liu
authors.forename: Aize
authors.initials: A
authors.lastname: Kijlstra
mesh_terms: D000328:Adult; D000483:Alleles; D001528:Behcet Syndrome / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D025841:Small Ubiquitin-Related Modifier Proteins / Q000235:genetics* / Q000276:immunology
chemical_list: C489647:SUMO4 protein, human; D025841:Small Ubiquitin-Related Modifier Proteins