Pt/TiO2 brain biocompatible nanoparticles: GBM treatment using the C6 model in Wistar rats.
In the present work we synthesized inorganic oxide nanoparticle carriers of platinum compounds and tested their therapeutic effect on animal models in which C6 glioma cells have been inoculated. TiO(2)-containing Pt(NH(3))(4)Cl(2) complexes were synthesized using sol-gel methods. The platinum species are chemically bonded to the TiO(2) carrier, as shown by Fourier transform infrared spectroscopy of probe molecules. Treatment with TiO(2)-Pt nanoparticles reduces tumour growth rate by up to 56%, showing that a synergistic effect exists between the TiO(2) carrier and the platinum drug.
López
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Universidad Autónoma Metropolitana-Xochimilco, Health Department, Calzada del Hueso 1100, México DF 04960, México.
Recillas
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Guevara
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Sotelo
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Alvarez
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Odriozola
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D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001932:Brain Neoplasms / Q000628:therapy*; D045744:Cell Line, Tumor; D004337:Drug Carriers; D005909:Glioblastoma / Q000628:therapy*; D008297:Male; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry; D044367:Phase Transition; D010984:Platinum / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D014025:Titanium / Q000737:chemistry*
D001672:Biocompatible Materials; D004337:Drug Carriers; D008823:Micelles; C009495:titanium dioxide; D010984:Platinum; D014025:Titanium