title: Epidural adhesiolysis complicated by cefazolin-induced status epilepticus: two cases.
abstract: Cefazolin is a strong epileptogenic agent. We describe two patients presenting with status epilepticus, apparently caused by intrathecal leakage of cefazolin via incidental dural puncture during spinal epidural adhesiolysis. Our cases suggest that the local use of antibiotics, particularly cefazolin, in the form of a mixture with contrast medium during a spinal procedure is not advisable, because of the possible incidental intrathecal leakage and the high convulsive potential of the antibiotics.
authors.affiliation: Department of Neurology, Korea University Medical Center, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jeong-Yoon
authors.initials: JY
authors.lastname: Choi
authors.forename: Hung Youl
authors.initials: HY
authors.lastname: Seok
authors.forename: Sang-Heon
authors.initials: SH
authors.lastname: Lee
authors.forename: Byung-Jo
authors.initials: BJ
authors.lastname: Kim
authors.forename: Kun-Woo
authors.initials: KW
authors.lastname: Park
authors.forename: Ki-Young
authors.initials: KY
authors.lastname: Jung
mesh_terms: D000368:Aged; D000767:Anesthesia, Epidural / Q000009:adverse effects / Q000379:methods*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D002437:Cefazolin / Q000008:administration & dosage / Q000009:adverse effects*; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007268:Injections, Epidural; D007472:Iohexol / Q000008:administration & dosage; D013129:Spinal Puncture / Q000009:adverse effects / Q000379:methods; D013226:Status Epilepticus / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D003287:Contrast Media; D007472:Iohexol; D002437:Cefazolin