Genetic aberrations in soft tissue leiomyosarcoma.
Leiomyosarcoma is a malignant mesenchymal tumor composed of cells showing smooth muscle differentiation. This tumor usually occurs in middle-aged or older adults, and forms a significant percentage of retroperitoneal, vascular, extremity, and uterine sarcomas. Leiomyosarcomas are most often associated with complex karyotypes with numerous chromosomal gains and losses. Some of these cytogenetic and molecular genetic aberrations correlate with histopathologic features and clinical outcomes. Identification of genetic alterations with specific identification of oncogenes and tumor suppressor genes may lead to additional insights into the tumorigenesis of leiomyosarcoma and the opportunity to confer the benefits of targeted therapy.
Yang
Jilong
J
Department of Bone and Soft Tissue Tumor, Tianjin Cancer Hospital and Institute, Tianjin Medical University, Tianjin 30060, China.
Du
Xiaoling
X
Chen
Kexin
K
Ylipää
Antti
A
Lazar
Alexander J F
AJ
Trent
Jonathan
J
Lev
Dina
D
Pollock
Raphael
R
Hao
Xishan
X
Hunt
Kelly
K
Zhang
Wei
W
D002869:Chromosome Aberrations; D003582:Cytogenetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D007621:Karyotyping; D007890:Leiomyosarcoma / Q000235:genetics*; D019656:Loss of Heterozygosity; D008495:Medical Oncology / Q000379:methods; D011379:Prognosis; D012107:Research Design; D012983:Soft Tissue Neoplasms / Q000235:genetics*