Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms.
A better understanding of interstructure relationship sustaining drug-resistant epileptogenic networks is crucial for surgical perspective and to better understand the consequences of epileptic processes on cognitive functions. We used resting-state fMRI to study basal functional connectivity within temporal lobes in medial temporal lobe epilepsy (MTLE) during interictal period. Two hundred consecutive single-shot GE-EPI acquisitions were acquired in 37 right-handed subjects (26 controls, eight patients presenting with left and three patients with right MTLE). For each hemisphere, normalized correlation coefficients were computed between pairs of time-course signals extracted from five regions involved in MTLE epileptogenic networks (Brodmann area 38, amygdala, entorhinal cortex (EC), anterior hippocampus (AntHip), and posterior hippocampus (PostHip)). In controls, an asymmetry was present with a global higher connectivity in the left temporal lobe. Relative to controls, the left MTLE group showed disruption of the left EC-AntHip link, and a trend of decreased connectivity of the left AntHip-PostHip link. In contrast, a trend of increased connectivity of the right AntHip-PostHip link was observed and was positively correlated to memory performance. At the individual level, seven out of the eight left MTLE patients showed decreased or disrupted functional connectivity. In this group, four patients with left TLE showed increased basal functional connectivity restricted to the right temporal lobe spared by seizures onset. A reverse pattern was observed at the individual level for patients with right TLE. This is the first demonstration of decreased basal functional connectivity within epileptogenic networks with concomitant contralateral increased connectivity possibly reflecting compensatory mechanisms.
Bettus
Gaelle
G
Centre de Résonance Magnétique Biologique et Médicale, UMR CNRS 6612, Faculté de Médecine, 27 Boulevard Jean Moulin, Marseille, France.
Guedj
Eric
E
Joyeux
Florian
F
Confort-Gouny
Sylviane
S
Soulier
Elisabeth
E
Laguitton
Virginie
V
Cozzone
Patrick J
PJ
Chauvel
Patrick
P
Ranjeva
Jean-Philippe
JP
Bartolomei
Fabrice
F
Guye
Maxime
M
D000328:Adult; D001611:Beta Rhythm / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009434:Neural Pathways / Q000098:blood supply / Q000473:pathology; D010100:Oxygen / Q000097:blood; D012146:Rest / Q000502:physiology; D013223:Statistics as Topic; D013702:Temporal Lobe / Q000098:blood supply*; D055815:Young Adult
D010100:Oxygen