title: [Laws of compound traditional Chinese medicine in treatment of dysmenorrhea].
abstract: Compound traditional Chinese medicine database was established by collecting 176 compound formulas for dysmenorrhea in the last twenty years. The proportion and frequency of herbal medicine were analyzed and the main herbs with mono-target or multi-target in the compound formulas were selected with simple and multiple linear regression. The linear regression equations were listed and the clinical effects of the compound formulas were evaluated. Of 173 herbs used in the compound formulas, the proportion and frequency of the herbs for activating blood and transforming stasis and regulating qi flow were high in the application. The dosage interval for 20 herbs in common use was estimated. Main herbs with mono-target or multi-target used in the compound formulas were selected with simple and multiple linear regression. The total effectiveness rate of the 176 compound formulas was tested with simple linear regression, and 167 compound formulas (94.84 % of the total) had the absolute error less than 4%. Herbs for activating blood and transforming stasis and regulating qi flow are most commonly used in treatment of dysmenorrhea. Clinical effects of the compound formulas could be forecast with stepwise regression equation.
authors.affiliation: Department of Traditional Chinese Medicine, Xinhua Hospital, Medical Collage, Shanghai Jiaotong University, Shanghai 200092, China. njl_tt@126.com
authors.forename: Jian-li
authors.initials: JL
authors.lastname: Ni
authors.forename: Pan
authors.initials: P
authors.lastname: Zhang
authors.forename: Fu-yao
authors.initials: FY
authors.lastname: Ren
mesh_terms: D000328:Adult; D004338:Drug Combinations; D004359:Drug Therapy, Combination / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004412:Dysmenorrhea / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016014:Linear Models; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy; D019413:Qi
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal