title: The ABCs of trans(porter) inhibition.
abstract: Transporter proteins mediate the import of nutrients and the export of toxins across biological membranes. A new crystal structure of a bacterial ABC transporter reveals an unexpected mechanism for transporter inhibition by its transported substrate.
authors.forename: Rachelle
authors.initials: R
authors.lastname: Gaudet
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors; D001692:Biological Transport; D018360:Crystallography, X-Ray; D011487:Protein Conformation; D017973:Tungsten Compounds / Q000737:chemistry / Q000494:pharmacology
chemical_list: D018528:ATP-Binding Cassette Transporters; D001426:Bacterial Proteins; D017973:Tungsten Compounds; C045951:tungstate