title: [Prospective evaluation of fracture risk in osteoporotic patients after low cement volume vertebroplasty].
abstract: OBJECTIVE
  To prospectively compare the incidence of new fractures (as demonstrated on MR) within the first 3 months after an initial fracture in a population treated with low cement volume vertebroplasty and a population treated conservatively.
  
  
  METHODS
  From 49 patients admitted for osteoporotic vertebral compression fracture, 22 underwent CT guided vertebroplasty with injection of 1-3 ml of PMMA, and 27 were treated conservatively. All patients underwent MR at presentation and at 3 months to detect new compression fractures.
  
  
  RESULTS
  Twelve patients (54%) treated with vertebroplasty showed new fractures at 3 months compared to 10 (37%) in the control group. This was not statistically different (p=0.049). In the vertebroplasty group, the new fractures involved vertebrae adjacent to the treated vertebra in 77% of cases (p=0.009) compared to only 15% in the control group. During the 3-month period, 3 patients, including 2 treated with vertebroplasty, required hospital admission due to fracture related acute lumbar back pain.
  
  
  CONCLUSIONS
  The small amount of injected cement does not prevent fractures of adjacent vertebrae but does reduce the extravasation of PMMA in adjacent tissues.
authors.affiliation: Service d'Imagerie Médicale, Hôpital Lapeyronie, Montpellier, France. c.cyteval@chu-montpellier.fr
authors.forename: C
authors.initials: C
authors.lastname: Cyteval
authors.forename: E
authors.initials: E
authors.lastname: Thomas
authors.forename: D
authors.initials: D
authors.lastname: Solignac
authors.forename: D
authors.initials: D
authors.lastname: Blin
authors.forename: E
authors.initials: E
authors.lastname: Decoux
authors.forename: F  M
authors.initials: F
authors.lastname: Lopez
authors.forename: F
authors.initials: F
authors.lastname: Blotman
authors.forename: P
authors.initials: P
authors.lastname: Taourel
mesh_terms: D000368:Aged; D001843:Bone Cements; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology* / Q000601:surgery*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000150:complications*; D011446:Prospective Studies; D018570:Risk Assessment; D016103:Spinal Fractures / Q000209:etiology* / Q000601:surgery*; D054854:Vertebroplasty / Q000379:methods*
chemical_list: D001843:Bone Cements