title: Effects of omentectomy on the peritoneal fibrinolytic system.
abstract: OBJECTIVE
  Decreased fibrinolytic activity in the serosal surfaces of peritoneal tissue appears to be a major factor in the development of peritoneal fibrous adhesions. The omentum reduces peritoneal adhesion by creating a mechanical barrier and producing fibrinolytic factors. This experimental study was designed to investigate the effects of omentectomy on the peritoneal fibrinolytic system.
  
  
  METHODS
  Thirty animals were assigned randomly to a control group or an omentectomy group. On postoperative day 10, peritoneal and blood samples were collected and adhesions were graded qualitatively. We measured the concentrations of serum and peritoneal tissue plasminogen activator, peritoneal plasminogen activator inhibitor-1, tissue plasminogen activator/plasminogen activator inhibitor complex, and hydroxyproline.
  
  
  RESULTS
  Adhesions were significantly increased after omentectomy. Omentectomy also resulted in a reduction of both serum and tissue "tissue plasminogen activator" levels. On the other hand, an increment in "plasminogen activator inhibitor-1" levels was observed after omentectomy. There were no differences in "tissue plasminogen activator/plasminogen activator inhibitor" complex or "hydroxyproline" levels.
  
  
  CONCLUSIONS
  Omentectomy reduced peritoneal fibrinolytic activity significantly and the peritoneal plasminogen activator system showed corruption that did not resolve with the rest of the peritoneal system after omentectomy.
authors.affiliation: General Surgery Department, Suleyman Demirel University, Modernevler 3103 sok. No 16, 32200, Isparta, Turkey.
authors.forename: Celal
authors.initials: C
authors.lastname: Cerci
authors.forename: Erol
authors.initials: E
authors.lastname: Eroglu
authors.forename: Recep
authors.initials: R
authors.lastname: Sutcu
authors.forename: Bilal
authors.initials: B
authors.lastname: Celikbas
authors.forename: Aynur
authors.initials: A
authors.lastname: Kilbas
mesh_terms: D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D005342:Fibrinolysis / Q000502:physiology*; D009852:Omentum / Q000601:surgery*; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000209:etiology*; D010959:Tissue Plasminogen Activator / Q000032:analysis
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator