Biflavanones, flavonoids, and coumarins from the roots of Stellera chamaejasme and their antiviral effect on hepatitis B virus.
A new 3,3''-biflavanone, isosikokianin A, was isolated from the roots of Stellera chamaejasme, together with eleven known compounds. Their structures and configurations were elucidated by spectroscopic methods including 2D-NMR techniques. Sikokianin A, chamaechromone, and quercetin showed in vitro antiviral activity against HBsAg secretion.
Yang
Guohong
G
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032, P. R. China.
Chen
Daofeng
D
D000998:Antiviral Agents / Q000494:pharmacology*; D044946:Biflavonoids / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006514:Hepatitis B Surface Antigens / Q000187:drug effects; D006513:Hepatitis B e Antigens / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D029752:Stellaria / Q000737:chemistry*
D000998:Antiviral Agents; D044946:Biflavonoids; D003374:Coumarins; D005419:Flavonoids; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens