title: Self-management of anticoagulation.
abstract: Treatment with vitamin K antagonists (i.e., warfarin or coumadin derivatives) requires repeated monitoring of the intensity of anticoagulation and regular dose adjustment. Nevertheless, many patients are not in the therapeutic target range for a considerable proportion (30-50%) of the time. In addition, repeated laboratory checks and visits to the (anticoagulation) clinic or office are time-consuming and may have a negative impact on patient satisfaction. Recently, reliable portable coagulometers have become available and these devices allow the measurement of the international normalized ratio (INR) from a small drop of capillary blood, thereby enabling patients to self-manage their anticoagulation. Clinical studies show that self-testing of the INR and self-adjusting of the warfarin dose results in a better control of anticoagulation in comparison with regular care by general practitioners or specialists and is at least as good as management by a specialized anticoagulation clinic. Moreover, treatment-related patient satisfaction and quality of life improves in patients performing self-management of anticoagulation.
authors.affiliation: Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.m.levi@amc.uva.nl
authors.forename: Marcel
authors.initials: M
authors.lastname: Levi
mesh_terms: D000553:Ambulatory Care / Q000379:methods; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001780:Blood Coagulation Tests / Q000295:instrumentation / Q000379:methods; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D019934:International Normalized Ratio; D017060:Patient Satisfaction; D012648:Self Care / Q000379:methods; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000925:Anticoagulants; D014859:Warfarin