title: Synthesis of a novel class of some 1,3,4-oxadiazole derivatives as antimicrobial agents.
abstract: In an effort to discover new candidates with improved antimicrobial activities we report here the synthesis and in vitro biological evaluation of various series of 2-{(3,4,5-trimethoxy phenyl-1,3,4-oxadiazolyl)-5-thio}-4-(morpholino)-6-(phenyl ureido)-s-triazine (7a-i) and 2-{(3,4,5-trimethoxy phenyl-1,3,4-oxadiazolyl)-5-thio}-4-(morpholino)-6-(phenyl thioureido)-s-triazine (8a-g). Antimicrobial properties of the title compounds were investigated against two Gram (+ ve) bacteria (S. aureus, B. subtilis), two Gram (- ve) bacteria (P. aeruginosa, E. coli) and yeast-like fungi (C. albicans) using the broth microdilution method.
authors.affiliation: Department of chemistry, School of Science, Gujarat University, Ahmedabad, 380 009, Gujarat, India.
authors.forename: Kishor H
authors.initials: KH
authors.lastname: Chikhalia
authors.forename: Dhaval B
authors.initials: DB
authors.lastname: Vashi
authors.forename: Mayank J
authors.initials: MJ
authors.lastname: Patel
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014227:Triazines / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D010069:Oxadiazoles; D014227:Triazines