title: Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat.
abstract: OBJECTIVE
  Stable gastric pentadecapeptide BPC 157 accelerates the healing of a transected Achilles tendon and a transected quadriceps muscle. It may also be of clinical relevance as a systemic and local peptide treatment for crush injury of a major muscle, such as gastrocnemius muscle complex. BPC 157 is effective without a carrier, and it is presently undergoing trials for inflammatory bowel disease, and no toxicity has so far been reported.
  
  
  METHODS
  In crushed rats (force delivered 0.727 Ns/cm2), BPC 157 was applied either intraperitoneally or locally, as a thin cream layer, immediately after injury (sacrifice at 2 h), and once a day for 14 days.
  
  
  RESULTS
  BPC 157 improved muscle healing, macroscopically (less hematoma and edema, no post-injury leg contracture), microscopically, functionally, and also based on enzyme activity (creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase).
  
  
  CONCLUSIONS
  BPC 157, at all investigated intervals, given locally or intraperitoneally, accelerated post-injury muscle healing and also helped to restore the full function.
authors.affiliation: Department of Pharmacology, Institute of Pathology, University of Zagreb Medical School, Salata 11, 10 000, Zagreb, Croatia.
authors.forename: Tomislav
authors.initials: T
authors.lastname: Novinscak
authors.forename: Luka
authors.initials: L
authors.lastname: Brcic
authors.forename: Mario
authors.initials: M
authors.lastname: Staresinic
authors.forename: Ivana
authors.initials: I
authors.lastname: Jukic
authors.forename: Bozo
authors.initials: B
authors.lastname: Radic
authors.forename: Danira
authors.initials: D
authors.lastname: Pevec
authors.forename: Sandro
authors.initials: S
authors.lastname: Mise
authors.forename: Sanja
authors.initials: S
authors.lastname: Tomasovic
authors.forename: Iva
authors.initials: I
authors.lastname: Brcic
authors.forename: Tihomir
authors.initials: T
authors.lastname: Banic
authors.forename: Ana
authors.initials: A
authors.lastname: Jakir
authors.forename: Gojko
authors.initials: G
authors.lastname: Buljat
authors.forename: Tomislav
authors.initials: T
authors.lastname: Anic
authors.forename: Ivan
authors.initials: I
authors.lastname: Zoricic
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Romic
authors.forename: Sven
authors.initials: S
authors.lastname: Seiwerth
authors.forename: Predrag
authors.initials: P
authors.lastname: Sikiric
mesh_terms: D000125:Achilles Tendon / Q000187:drug effects* / Q000293:injuries / Q000503:physiopathology; D000818:Animals; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011506:Proteins / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function; D018709:Statistics, Nonparametric; D013314:Stress, Mechanical; D013708:Tendon Injuries / Q000188:drug therapy* / Q000503:physiopathology; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D010446:Peptide Fragments; D011506:Proteins; C083833:BPC 157