[Changes in fatty acids content in blood red cells of patients with iron-deficiency anemia treated with sorbifer and mildronate].
OBJECTIVE
To study fractional composition of red cell membrane (RCM) lipids in patients with severe iron-deficiency anemia (IDA) complicated by myocardiodystrophy prior to treatment and after 1-month combined treatment with sorbifer and mildronate.


METHODS
Fatty acid composition of RCM lipids was studied in 12 patients with severe chronic posthemorrhagic IDA complicated by myocardiodystrophy and in 15 healthy subjects. Extraction of lipids from blood red cells and methylation of fatty acids were performed according to K.M. Sinyak et al. (1976). Relative content of fatty acids was determined at chromatography.


RESULTS
The study detected increased content of saturated fatty acids, especially palmitic and decreased content of unsaturated fatty acids especially fraction of omega6-polyunsaturated fatty acids: arachidonic and gamma-linolenic.


CONCLUSIONS
Sorbifer in combination with mildronate improved fatty acid composition of blood red cells in patients with iron-deficiency anemia.
Goncharova
E V
EV
Govorin
A V
AV
D018798:Anemia, Iron-Deficiency / Q000097:blood* / Q000188:drug therapy; D009202:Cardiomyopathies / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D002317:Cardiovascular Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D008763:Methylhydrazines / Q000627:therapeutic use*; D008875:Middle Aged; D016896:Treatment Outcome; D014810:Vitamin E / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use
D002317:Cardiovascular Agents; D005227:Fatty Acids; D008763:Methylhydrazines; D014815:Vitamins; D014810:Vitamin E; C050147:3-(2,2,2-trimethylhydrazine)propionate