Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice.
Epilepsy is one of the most common serious disorders of the brain. Several experimental studies have reported neuroprotective and antioxidant activity of certain natural products like curcumin, an active ingredient of turmeric. The present study was designed to explore the effect of acute administration of curcumin at doses 50, 100 and 200 mg/kg, orally (p.o.) and its chronic (x 21 days) administration in 100 mg/kg, p.o. on increasing current electroshock (ICES) test, elevated plus maze and actophotometer in mice. Curcumin in a dose of 100 mg/kg significantly increased the seizure threshold in ICES test on both acute and chronic administration. The same dose of 100 mg/kg on acute administration showed anxiogenic effect on elevated plus maze and actophotometer test. However, this anxiogenic effect of curcumin disappeared on chronic administration. These results suggest that curcumin appears to possess anticonvulsant activity in mice.
Bharal
Nidhi
N
Department of Pharmacology, University College of Medical Sciences, University of Delhi, Delhi 110095, India.
Sahaya
Kinshuk
K
Jain
Seema
S
Mediratta
Pramod K
PK
Sharma
Krishna K
KK
D000704:Analysis of Variance; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D005260:Female; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D012640:Seizures / Q000517:prevention & control*
D000927:Anticonvulsants; D003474:Curcumin