A synthetic method for peptide-PEG-lipid conjugates: application of octreotide-PEG-DSPE synthesis.
A solid phase synthesis method was established for the synthesis of peptide-poly(ethylene glycol)-lipid (peptide-PEG-lipid) conjugates. Octreotide-PEG(2000)-DSPE (OPD(2000)) was used as an example to demonstrate the synthetic approach. The OPD(2000) obtained had confirmed structure, activity, and purity providing a targeting molecule for preparation of well-defined drug delivery systems, such as targeted liposomes, for further studies.
Su
Jian-Chiou
JC
Department of Medical Research, Kuang Tien General Hospital, 5-2, Datong Street, Shalu, Taichung 43353, Taiwan, ROC.
Tseng
Chin-Lu
CL
Chang
Ting-Gung
TG
Yu
Wen-Jen
WJ
Wu
Shih-Kwang
SK
D002626:Chemistry, Pharmaceutical / Q000379:methods; D002845:Chromatography / Q000379:methods; D016503:Drug Delivery Systems; D007700:Kinetics; D008024:Ligands; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008968:Molecular Conformation; D015282:Octreotide / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D008024:Ligands; D008055:Lipids; D008081:Liposomes; D010455:Peptides; D010714:Phosphatidylethanolamines; C107570:polyethylene glycol-distearoylphosphatidylethanolamine; D011092:Polyethylene Glycols; D015282:Octreotide