title: Insulinomimetic Zn(II) complexes as evaluated by both glucose-uptake activity and inhibition of free fatty acids release in isolated rat adipocytes.
abstract: We prepared 4 new Zn(II) complexes with Zn(O4), Zn(N(2)O(2)), and Zn(S2O2) coordination modes and evaluated their insulinomimetic activities in an in vitro study. The insulinomimetic activities of bis(pyrrole-2-carboxylato)zinc (Zn(pc)2), bis(alpha-furonic acidato)zinc (Zn(fa)2), bis(thiophene-2-carboxylato)zinc (Zn(tc)2), and bis(thiophene-2-acetato)zinc (Zn(ta)2) complexes were found to be higher than that of zinc sulfate (ZnSO4). Zn(ta)2 showed the highest insulinomimetic activity among the Zn(II) complexes because of its high lipophilicity.
authors.affiliation: Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University, Kobe, Japan.
authors.forename: Midori
authors.initials: M
authors.lastname: Nishide
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Eriko U
authors.initials: EU
authors.lastname: Yoshikawa
authors.forename: Kinuyo
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Hiromu
authors.initials: H
authors.lastname: Sakurai
authors.forename: Naemi M
authors.initials: NM
authors.lastname: Kajiwara
mesh_terms: D017667:Adipocytes / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000737:chemistry; D051381:Rats; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D005230:Fatty Acids, Nonesterified; D007004:Hypoglycemic Agents; D007328:Insulin; D005947:Glucose; D015032:Zinc