title: [Fournier's gangrene--a model of necrotizing fasciitis (clinical and pathogenetic aspects)].
abstract: Pathogenesis of Fournier's disease was studied pathomorphologically and pathophysiologically. The underlying factor is thrombosis of the microcirculatory bed of the superficial fascia progressing into ischemic and hypoperfusion necrosis of the fascial structures manifesting with severe endotoxicosis and development of polyorganic insufficiency.
authors.forename: M V
authors.initials: MV
authors.lastname: Grinev
authors.forename: I V
authors.initials: IV
authors.lastname: Soroka
authors.forename: K M
authors.initials: KM
authors.lastname: Grinev
mesh_terms: D000328:Adult; D000368:Aged; D019115:Fasciitis, Necrotizing / Q000382:microbiology / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D018934:Fournier Gangrene / Q000382:microbiology / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged