title: The electrochemical modification of clenbuterol for biosensors of dopamine, norepinephrine, adrenalin, ascorbic acid and uric acid at paraffin-impregnated graphite electrode.
abstract: The electrochemical modification of clenbuterol (CLB) was studied at paraffin-impregnated graphite electrode (WGE) in two potential ranges of 0.0-1.6V and -1.2 to 1.2V. Various methods including X-ray photoelectron spectroscopy (XPS), UV-spectroelectrochemistry, infrared (IR) spectra and electrochemical techniques have been used to characterizing the modification. Clenbuterol can be modified at the electrode surface by carbon-nitrogen linkage or carbon-carbon linkage in 0.0-1.6V or -1.2 to 1.2V, respectively. The electrochemical behaviors of dopamine (DA), norepinephrine (NE), adrenalin (EP), ascorbic acid (AA) and uric acid (UA) were studied at clenbuterol-modified paraffin-impregnated graphite electrode (CLB/WGE), and it was found that all these compounds could be detected successfully.
authors.affiliation: Anhui Key Laboratory of Controllable Chemistry Reaction & Material Chemical Engineering, Hefei, PR China.
authors.forename: Guan-Ping
authors.initials: GP
authors.lastname: Jin
authors.forename: Xia
authors.initials: X
authors.lastname: Peng
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Ding
mesh_terms: D001205:Ascorbic Acid / Q000032:analysis*; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D002976:Clenbuterol / Q000737:chemistry*; D004298:Dopamine / Q000032:analysis*; D004563:Electrochemistry / Q000295:instrumentation; D004566:Electrodes; D004837:Epinephrine / Q000032:analysis*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006108:Graphite / Q000737:chemistry*; D009638:Norepinephrine / Q000032:analysis*; D010232:Paraffin / Q000737:chemistry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014527:Uric Acid / Q000032:analysis*
chemical_list: D014527:Uric Acid; D006108:Graphite; D010232:Paraffin; D001205:Ascorbic Acid; D004298:Dopamine; D009638:Norepinephrine; D002976:Clenbuterol; D004837:Epinephrine