title: Wilms' tumour: a complex enigma to decipher.
abstract: Wilms' tumour (WT) is the most common solid tumour of childhood. The molecular signalling pathways determining the origin and behaviour of WT are very complex and several genes in several loci may participate. This review tries to briefly compile recent works on the histology and on the molecular alterations that promote the genesis, development and behaviour of WT. Some molecular alterations seem to be associated with specific histological types and particular clinical outcomes, suggesting that they might be utilised to determine the prognosis and to identify poor prognostic subgroups that can be targeted for more individualised treatments.
authors.affiliation: Pathology Department, HH.UU Virgen del Rocío, Sevilla, Spain. mariaj.robles.exts@juntadeandalucia.es
authors.forename: María José
authors.initials: MJ
authors.lastname: Robles-Frías
authors.forename: Michele
authors.initials: M
authors.lastname: Biscuola
authors.forename: María  Angeles
authors.initials: M
authors.lastname: Castilla
authors.forename: María Angeles
authors.initials: MA
authors.lastname: López-García
authors.forename: Felicia
authors.initials: F
authors.lastname: Sánchez-Gallego
authors.forename: José
authors.initials: J
authors.lastname: Palacios
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D002869:Chromosome Aberrations; D016162:Genes, Wilms Tumor; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D009396:Wilms Tumor / Q000235:genetics* / Q000473:pathology