Diffuse large B-cell lymphoma presenting as multiple lymphomatous polyposis of the gastrointestinal tract.
Primary gastrointestinal (GI) lymphomas constitute 5%-10% of all gastrointestinal tumors. Involvement of the entire GI tract as multiple polypoid lesions is very rare. Multiple lymphomatous polyposis is a distinctive and rare type of malignant GI lymphoma. Multiple lymphomatous polyposis is thought to represent mantle cell lymphoma of the GI tract. Approximately 60 cases of MLP have been reported so far. We report the first case of diffuse large B-cell lymphoma presenting as multiple lymphomatous polyposis of the GI tract in a 49-year-old patient with HIV and describe the clinicopathologic features. The patient was treated with a combination therapy of highly active antiretroviral therapy and CHOP (cyclophosphamide/doxorubicin/vincristine/prednisone) and exhibited complete remission.
Andhavarapu
Swati
S
Department of Internal Medicine, Maricopa Medical Center, Phoenix, AZ 85008, USA. dr.aswati@gmail.com
Tolentino
Arturo M
AM
Jha
Chandra
C
Ravi
Jyotsna
J
Carlson
Richard
R
Nair
Geetha R
GR
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000008:administration & dosage; D005770:Gastrointestinal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006678:HIV; D015658:HIV Infections / Q000150:complications / Q000473:pathology*; D006801:Humans; D044483:Intestinal Polyposis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D012074:Remission Induction; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone