Successful therapy with ABLC, surgery and posaconazole for Rhizopus microsporus var. rhizopodiformis liver eumycetoma in a child with acute leukaemia.
Invasive fungal infection negatively influences the morbidity and mortality in heavily immuno-incompetent patients. Diagnosis of non-Aspergillus mould infections remains challenging despite application of a wide spectrum of non-culture-based microbiological techniques. Invasive diagnostic procedures are often essential. In this article, we present the case of a 15-month-old boy diagnosed with Rhizopus microsporus var. rhizopodiformis liver mycetoma during induction chemotherapy for acute promyelocytic leukaemia. Following surgery, he was effectively treated with a combination of ABLC and posaconazole during ongoing intensive chemotherapy. Posaconazole was also used as long-term secondary prophylaxis.
Sedlacek
Petr
P
Vavra
Vladimir
V
Masova
Ivana
I
Codl
Daniel
D
Laznickova
Tana
T
Malaskova
Ludmila
L
Nyc
Otakar
O
Stary
Jan
J
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D008099:Liver / Q000382:microbiology / Q000601:surgery; D008107:Liver Diseases / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery / Q000628:therapy*; D008297:Male; D008271:Mycetoma / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery / Q000628:therapy*; D012233:Rhizopus / Q000302:isolation & purification*; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; C068538:liposomal amphotericin B; C101425:posaconazole; D000666:Amphotericin B