Association of the STin2 polymorphism of the serotonin transporter gene with a neurocognitive endophenotype in major depressive disorder.
BACKGROUND
The aim of our study was to investigate the association of STin2 polymorphism and cognitive dysfunction in major depression.


METHODS
71 patients with major depression and 99 controls were genotyped for STin2. All depressive subjects and 30 controls also completed tests measuring neurocognitive performance.


RESULTS
We found a significantly higher frequency of the STin2.10/Stin2.10 homozygous genotype in the depressed group compared to controls. In the depressed group subjects with at least one copy of the 10-repeat allele showed decreased interference threshold in Stroop III compared to patients without the 10-repeat allele. Average performance of the depressed group without the 12-repeat allele was significantly weaker in the Rey Auditory Verbal Learning Test working memory and recall tasks compared to patients having at least one copy of the 12-repeat allele.


CONCLUSIONS
Our results suggest that the presence of STin2.10 and absence of STin2.12 allele may be related to a possible genetic endophenotype for characteristic cognitive dysfunctions detected in MDD.
Sarosi
Andrea
A
Department of Clinical and Theoretical Mental Health, Kútvölgyi Clinical Center, Semmelweis University, Kutvolgyi ut 4., 1125 Budapest, Hungary.
Gonda
Xenia
X
Balogh
Gabriella
G
Domotor
Eszter
E
Szekely
Anna
A
Hejjas
Krisztina
K
Sasvari-Szekely
Maria
M
Faludi
Gabor
G
D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000209:etiology / Q000235:genetics*; D003865:Major Depressive Disorder / Q000150:complications / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins