The role of insulin receptor substrate-1 in the oncogenicity  of simian virus 40 T antigen.
The Simian Virus 40 large T antigen (Tag) and the insulin receptor substrate-1 (IRS-1) interact with each other. Tag is a nuclear protein even in the absence of IRS-1, but IRS-1 is required for occupancy and activation by Tag of the ribosomal DNA (rDNA), cyclin D1 and c-myc promoters. Our results indicate that IRS-1 plays a significant role in Tag activation of cell cycle progression genes.
Wu
An
A
Thomas Jefferson University, Department of Cancer Biology, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA.
Chen
Jia
J
Baserga
Renato
R
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000952:Antigens, Polyomavirus Transforming / Q000378:metabolism*; D002453:Cell Cycle / Q000235:genetics*; D045744:Cell Line, Tumor; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism; D004275:DNA, Ribosomal / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D055504:Insulin Receptor Substrate Proteins; D011401:Promoter Regions, Genetic; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism; D013539:Simian virus 40
D048868:Adaptor Proteins, Signal Transducing; D000952:Antigens, Polyomavirus Transforming; D004275:DNA, Ribosomal; C526292:IRS1 protein, human; D055504:Insulin Receptor Substrate Proteins; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D019938:Cyclin D1