A new class of isoxazole derivatives: the M 1-9 series of compounds with immunotropic activity.
The isoxazole derivatives are interesting objects for synthesis in the search for various sorts of biological activity. Looking for more active immunomodulators we synthesized a series of 5-amino-3-methyl-4-isoxazolecarboxylic acid semicarbazides and thiosemicarbazides in the reaction of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide with isocyanates and isothiocyanates. The biological effect of these compounds on the proliferative response of human mononuclear peripheral blood cells to phytohemagglutinin A (PHA) was described.
Maczyński
Marcin
M
Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, 50-137 Wrocław, 9 Grodzka Str., Poland. marcinm@chorg.am.wroc.pl
Zimecki
Michał
M
Ryng
Stanisław
S
D006801:Humans; D007155:Immunologic Factors / Q000138:chemical synthesis* / Q000494:pharmacology; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D007155:Immunologic Factors; D007555:Isoxazoles