[Functional activity of metal contained enzymes with antioxidant activity in blood of patients with stomach cancer and during the use of anticancer autovaccine].
The authors presented in the article results of assessment of metal contained enzymes with antioxidant activity, ceruloplasmin (CP) in plasma blood, Cu-Zn superoxide dismutase (SOD) and catalase in red blood cells of patients with I-IV stage stomach cancer during surgical treatment and application of anticancer autovaccine (AAV) to prevent relapses and methastases. It was revealed compared with the donors that at stages of the treatment, before operation and after resuscitation, the level of activity of CP was higher in 1,3 times and in 3 times was higher the level of SOD. The change of catalase activity was within the limits of physiological values. Discrepancy in levels of activity of enzymes- synergists in relation to the elimination of radical forms testifies about the disbalance in functioning of the antioxidant system protection and is one of the signs of the manifestation of oxidant stress. The presence of wide ranges of changes in activity of metal contained enzymes before surgical operation and after resuscitation may depict the presence of significant tension in the functioning of antioxidant system in patients and may demand to carry out an analysis of each parameter. Normalization or stabilization of the level of activity of metal contained enzymes at the stage of surgical treatment or during the use of AAV reflects an availability of adaptation and compensatory mechanisms and it may be considered as a favorable prognostic factor of the treatment. The use of AAV in a complex treatment of patients with not local stomach canser lead to 3 years survival by 22% in comparison with surgical treatment of the patients.
P'iatchanina
T V
TV
Rozumiĭ
D O
DO
Mel'nykov
O R
OR
Momot
V Ia
VIa
Chornyĭ
V O
VO
Sydoryk
Ie P
IeP
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D019496:Cancer Vaccines / Q000627:therapeutic use*; D002374:Catalase / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D013274:Stomach Neoplasms / Q000097:blood / Q000201:enzymology / Q000517:prevention & control / Q000601:surgery; D013482:Superoxide Dismutase / Q000097:blood*; D016896:Treatment Outcome
D000975:Antioxidants; D019496:Cancer Vaccines; D002374:Catalase; D013482:Superoxide Dismutase