Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita.
Plant-parasitic nematodes are major agricultural pests worldwide and novel approaches to control them are sorely needed. We report the draft genome sequence of the root-knot nematode Meloidogyne incognita, a biotrophic parasite of many crops, including tomato, cotton and coffee. Most of the assembled sequence of this asexually reproducing nematode, totaling 86 Mb, exists in pairs of homologous but divergent segments. This suggests that ancient allelic regions in M. incognita are evolving toward effective haploidy, permitting new mechanisms of adaptation. The number and diversity of plant cell wall-degrading enzymes in M. incognita is unprecedented in any animal for which a genome sequence is available, and may derive from multiple horizontal gene transfers from bacterial sources. Our results provide insights into the adaptations required by metazoans to successfully parasitize immunocompetent plants, and open the way for discovering new antiparasitic strategies.
Abad
Pierre
P
INRA, UMR 1301, 400 route des Chappes, F-06903 Sophia-Antipolis, France. pierre.abad@sophia.inra.fr
Gouzy
Jérôme
J
Aury
Jean-Marc
JM
Castagnone-Sereno
Philippe
P
Danchin
Etienne G J
EG
Deleury
Emeline
E
Perfus-Barbeoch
Laetitia
L
Anthouard
Véronique
V
Artiguenave
François
F
Blok
Vivian C
VC
Caillaud
Marie-Cécile
MC
Coutinho
Pedro M
PM
Dasilva
Corinne
C
De Luca
Francesca
F
Deau
Florence
F
Esquibet
Magali
M
Flutre
Timothé
T
Goldstone
Jared V
JV
Hamamouch
Noureddine
N
Hewezi
Tarek
T
Jaillon
Olivier
O
Jubin
Claire
C
Leonetti
Paola
P
Magliano
Marc
M
Maier
Tom R
TR
Markov
Gabriel V
GV
McVeigh
Paul
P
Pesole
Graziano
G
Poulain
Julie
J
Robinson-Rechavi
Marc
M
Sallet
Erika
E
Ségurens
Béatrice
B
Steinbach
Delphine
D
Tytgat
Tom
T
Ugarte
Edgardo
E
van Ghelder
Cyril
C
Veronico
Pasqua
P
Baum
Thomas J
TJ
Blaxter
Mark
M
Bleve-Zacheo
Teresa
T
Davis
Eric L
EL
Ewbank
Jonathan J
JJ
Favery
Bruno
B
Grenier
Eric
E
Henrissat
Bernard
B
Jones
John T
JT
Laudet
Vincent
V
Maule
Aaron G
AG
Quesneville
Hadi
H
Rosso
Marie-Noëlle
MN
Schiex
Thomas
T
Smant
Geert
G
Weissenbach
Jean
J
Wincker
Patrick
P
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D018076:DNA, Complementary / Q000235:genetics; D018509:DNA, Helminth / Q000235:genetics; D020224:Expressed Sequence Tags; D017238:Genes, Helminth; D049751:Genome, Helminth; D008969:Molecular Sequence Data; D010935:Plant Diseases / Q000469:parasitology; D018517:Plant Roots / Q000469:parasitology; D010944:Plants / Q000469:parasitology*; D034622:RNA Interference; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D014431:Tylenchoidea / Q000235:genetics*
D018076:DNA, Complementary; D018509:DNA, Helminth