Immunology of mycobacterial infections: with special reference to Mycobacterium avium subspecies paratuberculosis.
The interplay between mycobacteria and host determines the outcome of infection. After uptake of mycobacteria by macrophages, several possible scenarios may emerge; mycobacteria may be destroyed immediately or there is establishment of persistent infection. This review is focused around mycobacteria-host interactions with reference to Mycobacterium avium subspecies paratuberculosis (MAP) infection and highlights protective mechanisms involved in order to design vaccines and other control strategies.
Sohal
Jagdeep Singh
JS
Central Institute for Research on Goats, Makhdoom, P.O. Farah, District Mathura 281122, Uttar Pradesh, India.
Singh
S V
SV
Tyagi
P
P
Subhodh
Swati
S
Singh
P K
PK
Singh
A V
AV
Narayanasamy
K
K
Sheoran
Neelam
N
Singh Sandhu
Komal
K
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D016927:Mycobacterium avium subsp. paratuberculosis / Q000276:immunology* / Q000472:pathogenicity; D010283:Paratuberculosis / Q000276:immunology* / Q000382:microbiology; D010587:Phagocytosis; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology / Q000378:metabolism; D051193:Toll-Like Receptors / Q000276:immunology* / Q000378:metabolism
D000907:Antibodies, Bacterial; D016207:Cytokines; D016692:Receptors, Antigen, T-Cell, gamma-delta; D051193:Toll-Like Receptors