title: Association of adiponectin with procollagen type I carboxyterminal propeptide in non-diabetic essential hypertension.
abstract: OBJECTIVE
  The serum concentration of procollagen type I carboxyterminal propeptide (PICP) is a good marker for collagen deposition in hypertension. Increased collagen deposition was associated with myocardial fibrosis and increased arterial stiffness. A decreased adiponectin level is associated with increased atherosclerosis. The role of adiponectin and its relation to PICP in essential hypertension have rarely been studied before.
  
  
  METHODS
  We recruited 188 non-diabetic uncomplicated hypertensive patients (mean age: 41+/-7 years; 128 men). No patient had vascular complications or renal or liver diseases. Overnight fasting blood samples were collected to assess patient lipid profiles, blood sugar, insulin, high-sensitivity C-reactive protein (hsCRP), PICP and adiponectin. Carotid to radial pulse wave velocity (PWV) measured using tonometry was used as an index of arterial stiffness.
  
  
  RESULTS
  Adiponectin (r = -0.216, p = 0.003) and male gender (p<0.001) were independent determinants of PICP. Diastolic blood pressure (r = 0.422, p<0.001) and current smoking (p = 0.005) were independent determinants of PWV. PWV was significantly correlated with PICP (r = 0.156, p = 0.034). Adiponectin was significantly correlated with triglyceride (r = -0.276, p<0.001), high-density lipoprotein (r = 0.262, p<0.001), the homeostasis model assessment (HOMA) index (r = -0.220, p = 0.002), hsCRP (r = -0.207, p = 0.004) and the body mass index (BMI) (r = -0.202, p = 0.005). After compensation with possible confounding factors, adiponectin was still significantly correlated with PICP (beta = -0.196, p = 0.006).
  
  
  CONCLUSIONS
  Serum adiponectin may be a marker for metabolic syndrome in essential hypertension. Adiponectin was significantly negatively correlated with PICP. Metabolic syndrome probably plays an important role in increased collagen synthesis and arterial stiffness through the effects of decreased adiponectin in non-diabetic essential hypertension.
authors.affiliation: Department of Internal Medicine, National Cheng Kung University Hospital Dou-Liou Branch, Dou-Liou, Taiwan. wctsai@ksmail.seed.net.tw
authors.forename: Wei-Chuan
authors.initials: WC
authors.lastname: Tsai
authors.forename: Chih-Chan
authors.initials: CC
authors.lastname: Lin
authors.forename: Ju-Yi
authors.initials: JY
authors.lastname: Chen
authors.forename: Yao-Yi
authors.initials: YY
authors.lastname: Huang
authors.forename: Cheng-Han
authors.initials: CH
authors.lastname: Lee
authors.forename: Wei-Ting
authors.initials: WT
authors.lastname: Li
authors.forename: Chiung-Mei
authors.initials: CM
authors.lastname: Weng
authors.forename: Jyh-Hong
authors.initials: JH
authors.lastname: Chen
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001158:Arteries / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood*; D001783:Blood Flow Velocity; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D003971:Diastole / Q000187:drug effects; D004548:Elasticity; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010045:Outpatients; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D011673:Pulsatile Flow; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D000959:Antihypertensive Agents; D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D010446:Peptide Fragments; D011347:Procollagen; D014280:Triglycerides; C042813:procollagen type I carboxy terminal peptide; D002097:C-Reactive Protein