Histiocytic necrotizing lymphadenitis without granulocytic infiltration (the so called Kikuchi-Fujimoto disease).
The report describes five cases of a rare disorder--necrotizing lymphadenitis--diagnosed in Polish patients in the Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow, in the years 1993-2006. The disease was firstly described by Kikuchi and Fujimoto in the Oriental population of Japan in 1972 and for this reason it is called Kikuchi-Fujimoto disease (or Kikuchi lymphadenitis). Its characteristic histological picture includes necrosis without granulocytic infiltrate surrounded by plasmocytoid monocytes, histiocytes (CD68+, lysozyme+, myeloperoxidase+) and immunoblasts, sometimes with atypia, with concomitant lymphocytes, predominantly cytotoxic T CD8+. The histology together with the rare occurrence of the disease in Poland may be a considerable diagnostic challenge for a pathologist, leading to misdiagnosing the lesion as a neoplastic process (malignant lymphoma).
Papla
Bolesław
B
Chair and Department of Pathomorphology, Collegium Medicum, Jagiellonian University Kraków.
Urbańczyk
Katarzyna
K
Gałazka
Krystyna
K
D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006098:Granulocytes / Q000473:pathology*; D006644:Histiocytes / Q000378:metabolism / Q000473:pathology; D020042:Histiocytic Necrotizing Lymphadenitis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis; D008297:Male; D009000:Monocytes / Q000378:metabolism / Q000473:pathology; D009113:Muramidase / Q000378:metabolism; D020556:Neutrophil Infiltration; D009195:Peroxidase / Q000378:metabolism; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015415:Biomarkers; D009113:Muramidase; D009195:Peroxidase; C067980:CD68 antigen, human; D000097382:CD68 Molecule