title: Biochemical cure of acromegaly after transsphenoidal surgery despite residual tumor on magnetic resonance imaging: case report.
abstract: A 52-year-old acromegalic woman underwent transsphenoidal removal of a pituitary macroadenoma. The tumor was totally removed apart from the part invading the right cavernous sinus. Postoperative magnetic resonance (MR) imaging demonstrated small residual tumor, but her acromegaly was "cured" using current strict criteria. The histological diagnosis was somatotroph cell adenoma with fibrous bodies. This biochemical cure persisted with no change in the residual tumor on MR imaging for 9 years without further treatment. Biochemical cure may not reflect total removal of the tumor, particularly if the growth hormone secretory activity of the residual tumor is low. Careful evaluation of postoperative MR imaging is always necessary to interpret surgical outcome, even if biochemical cure in acromegaly has been achieved.
authors.affiliation: Department of Neurosurgery, Tokyo Medical University, Tokyo, Japan. nishioka@tokyo-med.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishioka
authors.forename: Jo
authors.initials: J
authors.lastname: Haraoka
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000097:blood*; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000097:blood / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000097:blood / Q000175:diagnosis*; D010901:Pituitary Function Tests; D010902:Pituitary Gland / Q000473:pathology / Q000601:surgery; D010911:Pituitary Neoplasms / Q000097:blood / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis*; D013101:Sphenoid Sinus / Q000601:surgery*
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone