Joint disease mapping using six cancers in the Yorkshire region of England.
OBJECTIVE
The aims of this study were to model jointly the incidence rates of six smoking related cancers in the Yorkshire region of England, to explore the patterns of spatial correlation amongst them, and to estimate the relative weight of smoking and other shared risk factors for the relevant disease sites, both before and after adjustment for socioeconomic background (SEB).


METHODS
Data on the incidence of oesophagus, stomach, pancreas, lung, kidney, and bladder cancers between 1983 and 2003 were extracted from the Northern & Yorkshire Cancer Registry database for the 532 electoral wards in the Yorkshire region. Using postcode of residence, each case was assigned an area-based measure of SEB using the Townsend index. Standardised incidence ratios (SIRs) were calculated for each cancer site and their correlations investigated. The joint analysis of the spatial variation in incidence used a Bayesian shared-component model. Three components were included to represent differences in smoking (for all six sites), bodyweight/obesity (for oesophagus, pancreas and kidney cancers) and diet/alcohol consumption (for oesophagus and stomach cancers).


RESULTS
The incidence of cancers of the oesophagus, pancreas, kidney, and bladder was relatively evenly distributed across the region. The incidence of stomach and lung cancers was more clustered around the urban areas in the south of the region, and these two cancers were significantly associated with higher levels of area deprivation. The incidence of lung cancer was most impacted by adjustment for SEB, with the rural/urban split becoming less apparent. The component representing smoking had a larger effect on cancer incidence in the eastern part of the region. The effects of the other two components were small and disappeared after adjustment for SEB.


CONCLUSIONS
This study demonstrates the feasibility of joint disease modelling using data from six cancer sites. Incidence estimates are more precise than those obtained without smoothing. This methodology may be an important tool to help authorities evaluate healthcare system performance and the impact of policies.
Downing
Amy
A
Cancer Epidemiology Group, Centre for Epidemiology & Biostatistics, University of Leeds, Room 8, 49 Worsley Building, Leeds LS29LN, UK. a.downing@leeds.ac.uk
Forman
David
D
Gilthorpe
Mark S
MS
Edwards
Kimberley L
KL
Manda
Samuel Om
SO
D001835:Body Weight; D004739:England; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D015994:Incidence; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000209:etiology; D008019:Life Style; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology; D008962:Models, Theoretical; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D012959:Socioeconomic Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000209:etiology; D001749:Urinary Bladder Neoplasms / Q000209:etiology