title: Cardiac protection with volatile anesthetics in stenting procedures.
abstract: OBJECTIVE
  Myocardial ischemic damage is reduced by volatile anesthetics in patients undergoing coronary artery bypass graft surgery. The authors tested the hypothesis that low-dose sevoflurane could decrease perioperative myocardial damage, as measured by cTnI release, when compared with placebo, in patients undergoing interventional cardiology procedures.
  
  
  METHODS
  A single-blind, randomized controlled trial.
  
  
  METHODS
  A university hospital.
  
  
  METHODS
  Thirty patients undergoing stenting procedures (May 2005) were included in the present study.
  
  
  METHODS
  The authors randomly assigned 16 patients to breathe sevoflurane (expired end-tidal concentration 1%) and 14 patients to breathe a placebo oxygen/air mix before stenting procedures.
  
  
  RESULTS
  Postprocedural cardiac troponin I release was measured as a marker of myocardial necrosis. Sixteen patients had detectable cardiac troponin I levels after stenting procedures, with no difference between groups: 10 in the sevoflurane group (16 patients) versus 6 in the placebo group (14 patients) (p = 0.3). No difference in the amount of postprocedural median (interquartile range) cardiac troponin I release was noted between the sevoflurane group, 0.15 (0-4.73) ng/mL, and the placebo group, 0.14 (0-0.87) ng/mL (p = 0.4).
  
  
  CONCLUSIONS
  Myocardial damage measured by cardiac troponin release was not reduced by the volatile anesthetic sevoflurane during interventional cardiology procedures in this study.
authors.affiliation: Department of Cardiothoracic Anesthesia and Intensive Care, Università Vita-Salute San Raffaele e Istituto Scientifico San Raffaele, Milan, Italy. landoni.giovanni@hsr.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Landoni
authors.forename: Alberto
authors.initials: A
authors.lastname: Zangrillo
authors.forename: Oliviero
authors.initials: O
authors.lastname: Fochi
authors.forename: Giulia
authors.initials: G
authors.lastname: Maj
authors.forename: Anna Mara
authors.initials: AM
authors.lastname: Scandroglio
authors.forename: Andrea
authors.initials: A
authors.lastname: Morelli
authors.forename: Luigi
authors.initials: L
authors.lastname: Tritapepe
authors.forename: Matteo
authors.initials: M
authors.lastname: Montorfano
authors.forename: Antonio
authors.initials: A
authors.lastname: Colombo
mesh_terms: D000368:Aged; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000295:instrumentation*; D006801:Humans; D008738:Methyl Ethers / Q000008:administration & dosage; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology / Q000517:prevention & control; D019990:Perioperative Care / Q000009:adverse effects / Q000295:instrumentation; D000077149:Sevoflurane; D016037:Single-Blind Method; D015607:Stents; D014835:Volatilization
chemical_list: D018685:Anesthetics, Inhalation; D002316:Cardiotonic Agents; D008738:Methyl Ethers; D000077149:Sevoflurane