title: [Research progress on interactions between luteolin (glucosides) and drug-metabolizing enzyme].
abstract: The paper summarizes the interactions between luteolin (glucosides) and drug-metabolizing enzyme from the literature of recent years and our research work. The metabolism of luteolin is chiefly mediated by phase II metabolic enzyme. Its glucosides are firstly hydrolyzed into aglycone in intestinal tract, and then absorbed and metabolized. Luteolin has the effect on the induction of CYP3A, and on the inhibition of CYPIA, 1B and 2E. Also, luteolin is an effective inhibitor of CYP2B6, CYP2C9 and CYP2D6. Luteolin can induce and inhibit UGTs and SULTs. It can also inhibit multi ABC transport proteins. Understanding the interactions between luteolin (glucosides) and drug-metabolizing enzyme has an important significance in guiding clinical use of the drug.
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
authors.forename: Jing-Yan
authors.initials: JY
authors.lastname: Ying
authors.forename: Shao-Jun
authors.initials: SJ
authors.lastname: Gu
authors.forename: Tong-Wei
authors.initials: TW
authors.lastname: Yao
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D004347:Drug Interactions; D004790:Enzyme Induction; D014453:Glucuronosyltransferase / Q000378:metabolism; D006801:Humans; D047311:Luteolin / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D015238:Sulfotransferases / Q000378:metabolism
chemical_list: D018528:ATP-Binding Cassette Transporters; D001189:Aryl Hydrocarbon Hydroxylases; D014453:Glucuronosyltransferase; D015238:Sulfotransferases; D047311:Luteolin