Parallel memory processing by the CA1 region of the dorsal hippocampus and the basolateral amygdala.
There is abundant literature on the role of the basolateral amygdala (BLA) and the CA1 region of the hippocampus in memory formation of inhibitory avoidance (IA) and other behaviorally arousing tasks. Here, we investigate molecular correlates of IA consolidation in the two structures and their relation to NMDA receptors (NMDArs) and beta-adrenergic receptors (beta-ADrs). The separate posttraining administration of antagonists of NMDAr and beta-ADr to BLA and CA1 is amnesic. IA training is followed by an increase of the phosphorylation of calcium and calmodulin-dependent protein kinase II (CaMKII) and ERK2 in CA1 but only an increase of the phosphorylation of ERK2 in BLA. The changes are blocked by NMDAr antagonists but not beta-ADr antagonists in CA1, and they are blocked by beta-ADr but not NMDAr antagonists in BLA. In addition, the changes are accompanied by increased phosphorylation of tyrosine hydroxylase in BLA but not in CA1, suggesting that beta-AD modulation results from local catecholamine synthesis in the former but not in the latter structure. NMDAr blockers in CA1 do not alter the learning-induced neurochemical changes in BLA, and beta-ADr blockade in BLA does not hinder those in CA1. When put together with other data from the literature, the present findings suggest that CA1 and BLA play a role in consolidation, but they operate to an extent in parallel, suggesting that each is probably involved with different aspects of the task studied.
Cammarota
Martín
M
Centro de Memória, Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica de Rio Grande do Sul, Ipiranga Avenue 6690, RS 90610-000, Porto Alegre, Brazil.
Bevilaqua
Lia R
LR
Rossato
Janine I
JI
Lima
Ramón H
RH
Medina
Jorge H
JH
Izquierdo
Iván
I
D000647:Amnesia; D000679:Amygdala / Q000033:anatomy & histology* / Q000502:physiology; D000818:Animals; D001931:Brain Mapping / Q000379:methods; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism; D006624:Hippocampus / Q000033:anatomy & histology* / Q000502:physiology; D015151:Immunoblotting; D007858:Learning; D008297:Male; D008568:Memory; D008954:Models, Biological; D010766:Phosphorylation; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
D016194:Receptors, N-Methyl-D-Aspartate; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2