title: [Neurologic presentation in haemolytic-uraemic syndrome].
abstract: BACKGROUND
  Haemolytic-uraemic syndrome (HUS) is characterized by microangiopathic hemolytic anaemia, thrombopenia and multiorganic aggression, specially renal, gastrointestinal and central nervous system disturbances. Sporadic in Spain (2/1,500,000 inhabitants), its clinical onset includes acute renal failure, hypertension and central nervous system symptoms (irritability, drowsiness, convulsions, cortical blindness, hemiparesia or coma), due to metabolic distress, hypertension or central nervous system microangiopathy. Few long-term outcome studies have been published.
  
  
  METHODS
  A retrospective analysis of a series of 58 patients with HUS between 1981 and 2006, is reported. Clinical onset, laboratory, electrophysiology, neuroimaging tests, and prognosis factors are reviewed, together with long-term clinical outcome.
  
  
  RESULTS
  22 children presented neurologic symptoms, seven had some neurological test; one patient died; in five some neurological sequelae persisted (hemiparesia, cognitive deficit, visual-perception deficit), the other 16 remaining asymptomatic.
  
  
  CONCLUSIONS
  Neurological morbility is high in HUS (27% of the children with neurological symptoms), with a 1.7% mortality. Seizure at onset was not a poor prognosis factor in our group. No positive correlation can be established between neuroimaging and long-term outcome.
authors.affiliation: Servicio de Neurología, Hospital Sant Joan de Deu, 08950 Esplugues de Llobregat, España. aroche@hsjdbcn.org
authors.forename: A
authors.initials: A
authors.lastname: Roche-Martínez
authors.forename: P
authors.initials: P
authors.lastname: Póo
authors.forename: M
authors.initials: M
authors.lastname: Maristany-Cucurella
authors.forename: A
authors.initials: A
authors.lastname: Jiménez-Llort
authors.forename: J A
authors.initials: JA
authors.lastname: Camacho
authors.forename: J
authors.initials: J
authors.lastname: Campistol
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000150:complications*; D006801:Humans; D007223:Infant; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology*; D012189:Retrospective Studies