title: [Effect of puncturing shenshu point on the femoral biomechanical properties in senescence accelerated mouse prone 6].
abstract: OBJECTIVE
  To explore the mechanisms of puncturing Shenshu point in improving osteoporosis.
  
  
  METHODS
  Serum levels of testosterone (T) and osteocalcin (BGP) in senescence accelerated mouse prone 6 (SAMP6, test animals) and senescence accelerated mouse resistant 1 (SAMR1, for control) were determined by radioimmunoassay and their femoral biomechanical properties were determined with three-point bending test before and after puncturing to observe the effect of puncturing on the femoral biomechanical properties and bone mineral contents.
  
  
  RESULTS
  Compared with the SAMR1 control group, the serum level of T (20.91 +/- 3.41 nmol/L) decreased (11.09 +/- 1.48 nmol/L in SAMP6 mouse), BGP (6.7 +/- 2.07 microg/L) increased (12.29 +/- 2.29 microg/L in SAMP6 mouse), femoral bending strength lowered and fragility increased. These changes were all improved to some extent or normalized, serum T level 15.05 +/- 2.63 nmol/L and BGP 8.88 +/- 1.85 microg/L after needling at Shenshu point showed significant difference when compared with those in SAMP6.
  
  
  CONCLUSIONS
  Puncturing Shenshu point could effectively prevent the bone loss in SAMP6 mice, increase their bone strength, the therapeutic effect is partly by way of promoting the secretion of sex hormone, improving bone metabolism, suppressing bone transformation rate and increasing bone minerals.
authors.affiliation: Department of Biochemical Engineering, School of Chemical Engineering Technology, Tianjin University, Tianjin. zhangxuezhu1999@126.com
authors.forename: Xue-Zhu
authors.initials: XZ
authors.lastname: Zhang
authors.forename: Ying-Mei
authors.initials: YM
authors.lastname: Peng
authors.forename: Jian-Chun
authors.initials: JC
authors.lastname: Yu
mesh_terms: D015669:Acupuncture Points; D000375:Aging; D000818:Animals; D001696:Biomechanical Phenomena; D001835:Body Weight; D001862:Bone Resorption; D002118:Calcium / Q000378:metabolism; D005269:Femur / Q000378:metabolism* / Q000502:physiology* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008903:Minerals / Q000378:metabolism; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000097:blood / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D011677:Punctures / Q000379:methods*; D013739:Testosterone / Q000097:blood
chemical_list: D008903:Minerals; D015675:Osteocalcin; D013739:Testosterone; D002118:Calcium