title: Endothelin-1 may act as a negative inotropic agent in cardiac myocytes from young and senescent rats.
abstract: The contractile response to Endothelin-1 (ET-1) has been investigated in electrically stimulated single cardiac myocytes isolated from hearts of young and senescent rats. ET-1 (0.1-10 nM) exhibited a marked negative inotropic effect in both age groups. ET-1 (1.0 nM) also reduced the occurrence of spontaneous contractile oscillations in young myocytes, suggesting depletion of sarcoplasmic reticulum-Ca(2+) stores. The possibility that ET-1 may have opposite effects on myocardial contractility is discussed.
authors.affiliation: Laboratory of Experimental Cardiology, I.N.R.C.A., Via della Montagnola 164, Ancona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Fraticelli
authors.forename: L
authors.initials: L
authors.lastname: Rossi
authors.forename: A I
authors.initials: AI
authors.lastname: Socillo
authors.forename: C
authors.initials: C
authors.lastname: Boria
authors.forename: M C
authors.initials: MC
authors.lastname: Capogrossi
authors.forename: E
authors.initials: E
authors.lastname: Paciaroni