Recommendations for the treatment of hypertension in patients with DM: critical evaluation based on clinical trials.
Hypertension (blood pressure (BP) >140/90 mmHg) is a common comorbidity of type 2 DM (DM) and a major risk factor for macro- and microvascular complications. To review the effectiveness of different antihypertensive drugs in reducing BP, and diabetic complications in patients with DM, we analysed clinical trials, reviews and reports, published in Cochrane Library and PubMed from 1991 to 2004. Evidences suggest that optimal control of hypertension complications is obtained in diabetic patients when BP values are <130/80 mmHg. Different drug classes result useful to obtain this target BP, but their effects on different metabolic and non-metabolic aspects have to be taken in account and a flexible approach according to individual response to different regimens is essential.
Derosa
Giuseppe
G
Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy. giuderosa@tin.it
Salvadeo
Sibilla
S
Cicero
Arrigo F G
AF
D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003925:Diabetic Angiopathies / Q000188:drug therapy*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*