Ehlers-Danlos syndrome type IV with gastric adenocarcinoma.
BACKGROUND
Ehlers-Danlos syndrome has many subtypes. The vascular type (type IV) is characterized by thin, translucent skin, easy bruising, characteristic facial appearance, and arterial, intestinal, and/or uterine fragility.


OBJECTIVE
To encourage a better understanding of vascular EDS as a basis for early diagnosis, prevention, and management of complications. A first case of EDS type IV with adeno-carcinoma of the stomach in Thailand was reported and literature was reviewed.


RESULTS
A 62-year-old Thai priest was admitted in Priest Hospital because of progressive muscle weakness of both legs with neurogenic claudication from compression fracture of L1-2. Abdominal aortic aneurysm were detected with upper gastrointestinal hemorrhage, esophagogastroduodenoscopy showed diffuse gastric body swelling and erythema resulting in chronic gastritis. Gastric biopsy was indicative of adenocarcinoma of the stomach and gastrectomy was done. Dermatologists were consulted due to generalized cutaneous pain, easy bruising following venepuncture, and EKG padding. A vascular EDS type IV was diagnosed.


CONCLUSIONS
After gastrectomy, the patient became drowsy and unconscious from profuse recurrent cerebral hemorrhage and expired.
Kanechorn Na Ayuthaya
Rajyani
R
Department ofDermatology, Phramongkutklao Hospital, Thailand.
Patthamapasphong
Nonthaya
N
Sura
Thanyachai
T
Niumpradit
Nucha
N
Trachoo
Objoon
O
D000230:Adenocarcinoma / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D024061:Collagen Type III / Q000235:genetics; D004535:Ehlers-Danlos Syndrome / Q000209:etiology* / Q000235:genetics; D017809:Fatal Outcome; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000150:complications* / Q000503:physiopathology / Q000601:surgery
C439971:COL3A1 protein, human; D024061:Collagen Type III