title: A versatile and regiospecific synthesis of functionalized 1,3-diarylisobenzofurans.
abstract: A convenient, versatile, and regiospecific synthesis of functionalized 1,3-diarylisobenzofurans has been developed. It involves chemoselective addition of arylmagnesium reagents to the aldehyde function of o-aroylbenzaldehydes, themselves readily obtained by lead tetraacetate oxidation of N-aroylhydrazones of salicylaldehydes. Various functional groups, including nitro, iodo, or ester functionalities, have thus been positioned with complete regiospecificity on the 1,3-diphenylisobenzofuran backbone.
authors.affiliation: Département de Chimie Moléculaire (SERCO), UMR-5250, ICMG FR-2607, Université Joseph Fourier, 301 Rue de la Chimie, BP 53, 38041 Grenoble Cedex 9, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Jacq
authors.forename: Cathy
authors.initials: C
authors.lastname: Einhorn
authors.forename: Jacques
authors.initials: J
authors.lastname: Einhorn