Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation.
Nectins and nectin-like molecules (Necls) are immunoglobulin-like transmembrane cell adhesion molecules that are expressed in various cell types. Homophilic and heterophilic engagements between family members provide cells with molecular tools for intercellular communications. Nectins primarily regulate cell-cell adhesions, whereas Necls are involved in a greater variety of cellular functions. Recent studies have revealed that nectins and NECL-5, in cooperation with integrin alphavbeta3 and platelet-derived growth factor receptor, are crucial for the mechanisms that underlie contact inhibition of cell movement and proliferation; this has important implications for the development and tissue regeneration of multicellular organisms and the phenotypes of cancer cells.
Takai
Yoshimi
Y
Department of Biochemistry and Molecular Biology, Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan. ytakai@med.kobe-u.ac.jp
Miyoshi
Jun
J
Ikeda
Wataru
W
Ogita
Hisakazu
H
D000818:Animals; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D049109:Cell Proliferation; D003260:Contact Inhibition / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D000075983:Nectins; D011991:Receptors, Virus / Q000502:physiology
D015815:Cell Adhesion Molecules; D000075983:Nectins; D011991:Receptors, Virus; C066100:poliovirus receptor