title: Changing incidence of pancreatic neoplasms: a 16-year review of statewide tumor registry.
abstract: OBJECTIVE
  Although most pancreatic neoplasms are adenocarcinoma, there are many other histological types, some of which may be increasing in frequency. To better define these trends, we reviewed 16 years of data from a statewide tumor registry.
  
  
  METHODS
  Using the State of Michigan tumor registry, all patients with primary pancreatic cancers from 1986 to 2002 were identified, and patients were excluded if there were insufficient data or the histological subtype was not clearly defined in the literature.
  
  
  RESULTS
  There were 17,610 pancreatic neoplasms identified, and 2425 were excluded, leaving a final population of 15,185. Twenty-five types of primary pancreatic neoplasms were identified. The most common were adenocarcinoma, mucinous cystadenocarcinoma, nonfunctional neuroendocrine, adenosquamous, anaplastic, intraductal papillary mucinous, and acinar cell (8.37, 0.43, 0.18, 0.05, 0.04, 0.04, and 0.02 per 100,000 per year, respectively). The mean age at presentation was similar for tumor types, 69.2 years old, with the exception of endocrine neoplasms occurring at a younger age, 58.5 years old (P < 0.0005). There was a significant change in the incidence of nonfunctional neuroendocrine neoplasms, greater than 2-fold increase (P = 0.0003).
  
  
  CONCLUSIONS
  The incidence of most pancreatic neoplasms has changed a little; however, nonfunctional neuroendocrine neoplasms increased greater than 2-fold. The etiology of this change is unclear.
authors.affiliation: Department of Surgical Oncology, Richard J Lacks Cancer Center, Grand Rapids, MI 49503, USA. fitzgetl@trinity-health.org
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Fitzgerald
authors.forename: Zach J
authors.initials: ZJ
authors.lastname: Hickner
authors.forename: Matthew
authors.initials: M
authors.lastname: Schmitz
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Kort
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology; D000368:Aged; D018267:Carcinoma, Acinar Cell / Q000453:epidemiology; D018196:Carcinoma, Adenosquamous / Q000453:epidemiology; D021441:Carcinoma, Pancreatic Ductal / Q000453:epidemiology; D018282:Cystadenocarcinoma, Mucinous / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000453:epidemiology; D010190:Pancreatic Neoplasms / Q000453:epidemiology*; D012042:Registries; D013997:Time Factors