title: Histopathological changes in the placentas and fetuses of mice infected with Trypanosoma cruzi isolated from the Myotis nigricans nigricans bat.
abstract: Histopathological changes and placental transmission were studied in the late stages of pregnancy in mice infected with a strain of Trypanosoma cruzi, isolated from a Myotis nigricans nigricans bat. Large amastigote nests were observed in uterine muscles, as well as in decidual and endothelial placental cells. In addition, persistent coagulative and fibrotic vascular degeneration was observed. Large amastigote burdens were found in giant cells, spongioblasts and endothelial cells within the labyrinthine layer. Transplacental transmission was confirmed in 30% of the fetuses examined, in which amastigote nests were seen only in striated muscle. During the acute phase, intrauterine development was impaired as the result of parasitic invasion of the placenta, and fetal mortality rose to 10%.
authors.affiliation: Laboratório de Parasitologia, Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto/FCFRP-USP, São Paulo, Brazil.
authors.forename: E S
authors.initials: ES
authors.lastname: Badra
authors.forename: M A
authors.initials: MA
authors.lastname: Sala
authors.forename: R A
authors.initials: RA
authors.lastname: Lopes
authors.forename: J C
authors.initials: JC
authors.lastname: Prado
authors.forename: S
authors.initials: S
authors.lastname: Albuquerque
authors.forename: S
authors.initials: S
authors.lastname: Zucoloto
authors.forename: A A
authors.initials: AA
authors.lastname: Carraro-Abrahão
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000473:pathology / Q000635:transmission*; D002685:Chiroptera / Q000469:parasitology; D005260:Female; D005333:Fetus / Q000469:parasitology*; D018445:Infectious Disease Transmission, Vertical; D051379:Mice; D018512:Parasitemia; D010920:Placenta / Q000469:parasitology* / Q000473:pathology*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000473:pathology*; D014349:Trypanosoma cruzi