Cellular mechanisms of tumour suppression by the retinoblastoma gene.
The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad range of paediatric and adult cancers, and a plethora of cellular functions and partners have been identified for the RB protein. Data from human tumours and studies from mouse models indicate that loss of RB function contributes to both cancer initiation and progression. However, we still do not know the identity of the cell types in which RB normally prevents cancer initiation in vivo, and the specific functions of RB that suppress distinct aspects of the tumorigenic process are poorly understood.
Burkhart
Deborah L
DL
Cancer Biology Program, Stanford University School of Medicine, Stanford, California 94305, USA.
Sage
Julien
J
D000818:Animals; D002453:Cell Cycle; D002454:Cell Differentiation; D016161:Genes, Retinoblastoma; D016147:Genes, Tumor Suppressor; D006801:Humans; D009154:Mutation; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000235:genetics*; D009389:Neovascularization, Pathologic; D011485:Protein Binding; D012323:RNA Processing, Post-Transcriptional; D013234:Stem Cells / Q000378:metabolism