title: Photothermal response of superparamagnetic iron oxide nanoparticles.
abstract: OBJECTIVE
  Superparamagnetic iron oxide nanoparticles have been used as MRI contrast agents in medical imaging. The purpose of this study was to explore the photothermal response of superparamagnetic iron oxide nanoparticles for biomedical applications.
  
  
  METHODS
  Absorbance, temperature increase, and optical path length change of solutions of superparamagnetic iron oxide nanoparticles, SPIO and MION, in response to a 532 nm pulsed laser irradiation were measured.
  
  
  RESULTS
  Both SPIO and MION showed absorption at 532 nm, temperature increase, and optical path length change. SPIO and MION underwent selective heating due to absorption of laser energy (532 nm).
  
  
  CONCLUSIONS
  Temperature increase and optical path length change of SPIO and MION in response to 532 nm pulsed laser irradiation demonstrate a potential application of these particles in biomedical imaging. For further study, additional experiments applying the photothermal response of SPIO and MION in tissues are required.
authors.affiliation: Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208, USA. jihoon-kim@northwestern.edu
authors.forename: Jihoon
authors.initials: J
authors.lastname: Kim
authors.forename: Junghwan
authors.initials: J
authors.lastname: Oh
authors.forename: Hyun Wook
authors.initials: HW
authors.lastname: Kang
authors.forename: Marc D
authors.initials: MD
authors.lastname: Feldman
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Milner
mesh_terms: D002478:Cells, Cultured / Q000473:pathology / Q000528:radiation effects*; D052203:Ferrosoferric Oxide / Q000494:pharmacology; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D028022:Low-Level Light Therapy; D053758:Nanoparticles; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence
chemical_list: C499827:monocrystalline iron oxide nanoparticle; D052203:Ferrosoferric Oxide