title: Salivary epidermal growth factor levels in Behçet's disease and recurrent aphthous stomatitis.
abstract: BACKGROUND
  Epidermal growth factor (EGF) in saliva is cytoprotective against injuries and contributes to the maintenance of the integrity of the gastrointestinal mucosa. Low salivary EGF levels have been observed in patients with various forms of oral mucosal disease.
  
  
  OBJECTIVE
  Our aim was to determine whether salivary EGF is low in patients with recurrent aphthous stomatitis (RAS) or those with Behçet's disease (BD) when compared with healthy controls.
  
  
  METHODS
  The study population consisted of 33 BD and 16 RAS patients and 60 healthy controls. Measurement of EGF concentration in human saliva was performed with an enzyme-linked immunosorbent assay using an antibody-coated solid phase.
  
  
  RESULTS
  The mean salivary EGF levels (+/-SD) of active (with oral ulceration) and inactive stages (absence of oral ulceration) of BD (1,939.7 +/- 1,561.5 and 2,305.7 +/- 1,481.6 pg/ml, respectively) and RAS patients (1,650.5 +/- 704.7 and 1,069.9 +/- 539.2 pg/ml, respectively) were both lower than those of the healthy controls (2,758.7 +/- 1,657.9 pg/ml) (p < 0.05 for each).
  
  
  CONCLUSIONS
  BD and RAS patients have reduced salivary EGF levels even in the absence of oral ulcerations. EGF could be involved in the pathogenesis of BD and RAS by disturbing the mucosal integrity that may result in a susceptibility to the development of oral ulcers in these diseases.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Gazi University, Ankara, Turkey. eozsoy@gazi.edu.tr
authors.forename: Esra
authors.initials: E
authors.lastname: Adişen
authors.forename: Arzu
authors.initials: A
authors.lastname: Aral
authors.forename: Cemalettin
authors.initials: C
authors.lastname: Aybay
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Gürer
mesh_terms: D000293:Adolescent; D000328:Adult; D001528:Behcet Syndrome / Q000378:metabolism*; D003078:Colchicine / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D004815:Epidermal Growth Factor / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012463:Saliva / Q000737:chemistry*; D013281:Stomatitis, Aphthous / Q000378:metabolism*
chemical_list: D004815:Epidermal Growth Factor; D003078:Colchicine