Famciclovir substitution for patients with acyclovir-associated renal toxicity.
Acyclovir-induced nephrotoxicity is well known, but published literature lacks information on the safety of substitution with other antiviral agents. We describe four patients with acyclovir-induced renal toxicity that were subsequently managed with hydration and famciclovir. All four patients subsequently had improvements in their symptoms with full recovery of their baseline renal function.
Htwe
Tin Han
TH
Division of Infectious Diseases, Department of Medicine, Southern Illinois University School of Medicine, Springfield, P.O. Box-19636, IL 62794-9636, USA.
Bergman
Scott
S
Koirala
Janak
J
D015075:2-Aminopurine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000212:Acyclovir / Q000008:administration & dosage / Q000633:toxicity*; D000368:Aged; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000627:therapeutic use* / Q000633:toxicity*; D000077595:Famciclovir; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy*; D006562:Herpes Zoster / Q000188:drug therapy*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged
D000998:Antiviral Agents; D015075:2-Aminopurine; D000077595:Famciclovir; D000212:Acyclovir