Double aneuploidy in spontaneous miscarriages: two case reports and review of the literature.
The occurrence of double aneuploidy is a relatively rare phenomenon. The clinical presentations are variable depending on the predominating aneuploidy or a combination effect of both. We report the cytogenetic data on products of conception from miscarriages over a period of 5 years. A total of 403 miscarriages were karyotyped and the tissues were villi in all cases. Of 403 cases, 54 cases with single aneuploidy and 2 cases of first-trimester miscarriages with double trisomies were found. These 2 cases with the karyotypes of 48,XXY,+15 and 48,XX,+5,+7 were cited for the first time in this study.
Korucuoglu
Umit
U
Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey. korucu23@yahoo.com
Erdem
Mehmet
M
Pala
Elif
E
Karaoguz
Meral Yirmibes
MY
Erdem
Ahmet
A
Biri
Aydan
A
D000022:Abortion, Spontaneous / Q000000981:diagnostic imaging / Q000235:genetics* / Q000601:surgery; D000328:Adult; D001919:Bradycardia / Q000000981:diagnostic imaging / Q000196:embryology; D015193:Chorionic Villi Sampling; D004107:Dilatation and Curettage; D005260:Female; D006801:Humans; D007621:Karyotyping; D010063:Ovum / Q000473:pathology; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014314:Trisomy; D016216:Ultrasonography, Prenatal; D015017:Yolk Sac / Q000000981:diagnostic imaging