title: The binding of antibiotics to ERp57/GRP58.
abstract: The effects of five antibiotics, previously described as ligands of protein disulfide isomerase PDI, have now been studied on the homologous protein ERp57. They bind to this protein with much higher affinity than to PDI, and some of them inhibit the reductase and the DNA-binding activities of ERp57. In view of the high affinity of vancomycin, erythromycin and streptomycin, some effects of their interaction with this protein might be expected in vivo.
authors.affiliation: Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Sapienza-Università di Roma, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Gaucci
authors.forename: Silvia
authors.initials: S
authors.lastname: Chichiarelli
authors.forename: Caterina
authors.initials: C
authors.lastname: Grillo
authors.forename: Emiliana Del
authors.initials: ED
authors.lastname: Vecchio
authors.forename: Margherita
authors.initials: M
authors.lastname: Eufemi
authors.forename: Carlo
authors.initials: C
authors.lastname: Turano
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D001665:Binding Sites; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D011485:Protein Binding; D019704:Protein Disulfide-Isomerases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; D008024:Ligands; D011994:Recombinant Proteins; D004247:DNA; D019704:Protein Disulfide-Isomerases; C085868:PDIA3 protein, human