Effort awareness and sense of volition in schizophrenia.
Contemporary experimental research has emphasised the role of centrally generated signals arising from premotor areas in voluntary muscular force perception. It is therefore generally accepted that judgements of force are based on a central sense, known as the sense of effort, rather than on a sense of intra-muscular tension. Interestingly, the concept of effort is also present in the classical philosophy: to the French philosopher Maine de Biran [Maine de Biran (1805). Mémoire sur la décomposition de la pensée (Tome III), Vrin, Paris (1963)], the sense of effort is the fundamental component of self-experience, the landmark of the exercise of the will. In the present review, after a presentation of the nature and neurophysiological bases of effort sensation, we will examine its possible involvement in the neurocognitive process of agency. We will further focus on delusions of alien control in schizophrenic patients. Experimental data suggest that these patients have an abnormal awareness of effort caused by cerebral anomalies in the frontal and parietal lobes.
Lafargue
Gilles
G
Lab Neurosciences Fonctionnelles & Pathologies, CNRS, Université Lille Nord-de-France, France. gilles.lafargue@univ-lille3.fr
Franck
Nicolas
N
D001364:Awareness; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D003702:Delusions / Q000209:etiology / Q000523:psychology; D005625:Frontal Lobe / Q000002:abnormalities / Q000503:physiopathology*; D006801:Humans; D033182:Intention; D008279:Magnetic Resonance Imaging; D009119:Muscle Contraction; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000002:abnormalities / Q000503:physiopathology*; D010468:Perceptual Disorders / Q000209:etiology; D005082:Physical Exertion; D017397:Prefrontal Cortex / Q000502:physiology; D012559:Schizophrenia / Q000150:complications* / Q000503:physiopathology*; D014836:Volition