Costly mistakes: translational infidelity and protein homeostasis.
Protein misfolding is increasingly being recognized as a key process in organismal health and disease. Drummond and Wilke (2008) show that misfolding caused by mistakes during the translation of RNA into proteins (mistranslation) also results in a strong selection pressure to optimize translational fidelity, especially for proteins that are highly expressed.
Powers
Evan T
ET
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037, USA. epowers@scripps.edu
Balch
William E
WE
D000818:Animals; D015870:Gene Expression; D006801:Humans; D014176:Protein Biosynthesis; D017510:Protein Folding; D011506:Proteins / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism; D012641:Selection, Genetic
D011506:Proteins