[Expression and function of toll-like receptors in B lymphocytes].
Toll-like receptors (TLRs) are widely expressed in the innate and adaptive immune system. They initiate host defense against endogenous and exogenous pathogens containing conserved pathogen associated molecular patterns. TLRs are critical bridges between the innate and adaptive immunity, especially the cellular immunity mediated by T cells. Emerging evidence indicated that B cells express almost all subtypes of TLRs. TLRs play critical role not only in regulation of proliferation, maturation and function of B cells, but also in pathogenesis of diseases, such as systemic lupus erythematosus and chronic lymphocytic leukemia. Targeting TLRs of B cells is a promising therapeutic strategy for these disorders.
Liu
Han-Zhi
HZ
Institute of Materia Medica CAMS and PUMC, Beijing, China.
Yang
Hong-Zhen
HZ
Hu
Zhou-Wei
ZW
D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism* / Q000502:physiology
D051193:Toll-Like Receptors