title: Room temperature ICl-induced dehydration/iodination of 1-acyl-5-hydroxy-4,5-dihydro-1H-pyrazoles. a selective route to substituted 1-acyl-4-iodo-1H-pyrazoles.
abstract: A number of new functionally substituted 1-acyl-5-hydroxy-4,5-dihydro-1H-pyrazoles have been prepared in moderate to excellent yields from the corresponding 2-alkyn-1-ones. The resulting dihydropyrazoles undergo dehydration and iodination in the presence of ICl and Li2CO3 at room temperature to provide 1-acyl-4-iodo-1H-pyrazoles.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: Jesse P
authors.initials: JP
authors.lastname: Waldo
authors.forename: Saurabh
authors.initials: S
authors.lastname: Mehta
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock
mesh_terms: D000215:Acylation; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D054879:Halogenation; D006900:Hydroxylation; D016651:Lithium Carbonate / Q000737:chemistry; D008956:Models, Chemical; D010165:Palladium / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis*; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D011720:Pyrazoles; D014867:Water; D016651:Lithium Carbonate; D010165:Palladium; D003300:Copper