Synthesis of 2,3-dihydro-7-nitroimidazo[5,1-b]oxazoles as potential tuberculostatic agents.
A series of 2,3-dihydro-7-nitroimidazo[5,1-b]oxazoles has been prepared in one-pot reaction. The proposed new method of their synthesis requires a treatment of 4,5-dinitroimidazole or 2-methyl-4,5-dinitroimidazole with oxiranes. Some of the obtained compounds have been tested in vitro for antimycobacterial activity and the spatial structure of them has been also discussed.
Zwawiak
Justyna
J
Chair and Department of Organic Chemistry, Pharmaceutical Faculty, Poznań University of Medical Sciences, 6 Grunwaldzka Str., 60-780 Poznań, Poland.
Olender
Dorota
D
Zwolska
Zofia
Z
Augustynowicz-Kopeć
Ewa
E
Zaprutko
Lucjusz
L
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000995:Antitubercular Agents; D010080:Oxazoles