title: The delta fractional flow reserve can predict lesion severity and long-term prognosis.
abstract: BACKGROUND
  Fractional flow reserve (FFR) is a method which is used to identify the angiographically intermediate lesions requiring revascularization. However, physiological importance and clinical usability of delta (Delta) FFR, the difference between FFR in baseline conditions (FFRbase, resting) and after adenosine administration (FFRmin, hyperemic), is currently unknown. We aimed to investigate whether DeltaFFR may be helpful in the identification of the lesion severity and predictability of long-term prognosis.
  
  
  RESULTS
  We enrolled 123 consecutive patients with an intermediate lesion (40-70% stenosis) at LAD in this study. The patients were divided into three groups according to FFRmin results (group I: FFR>0.80, n=71; group II: FFR between 0.75 and 0.80, n=28; group III: FFR<0.75, n=24). We followed the patients for a mean duration of 36+/-17 months for major adverse cardiac events (MACE). For the sensitivity and the specificity of DeltaFFR to detect the lesion severity, the area under ROC curve was found as 0.873 (95% CI: 0.788-0.958, P<0.001). When >or=15 is accepted as the cut-off value for DeltaFFR, the specificity was 95%, the sensitivity was 59% for lesion severity. When we compared the predictability of MACE by FFRmin and DeltaFFR, there is no difference in FFRmin groups (FFR<0.75, 0.75-0.80 and FFR>0.80) (29%, 46% and 30%, respectively, P=0.247). However, between the groups which were determined according to cut-off values for DeltaFFR (DeltaFFR<10; DeltaFFR, 10-15; DeltaFFR>or=15) among the patients with FFR<or=0.80, MACE was significantly different (73%, 44%, 11%; respectively, P=0.003).
  
  
  CONCLUSIONS
  DeltaFFR may represent the vascular ischemic compensatory capacity to a significant lesion and this response capacity shows the severity of the lesion with high specificity. Decreased and insufficient vascular response capacity to a significantly lesion relates to the poor long-term clinical prognosis. DeltaFFR may be helpful in the identification of the lesion severity in the assessment of intermediate coronary lesions; it can be used as a guide for revascularization decision and in predictability of long-term clinical prognosis.
authors.affiliation: Gazi University School of Medicine, Department of Cardiology, Besevler 06500, Ankara, Turkey. sinanaltan@gmail.com
authors.forename: Sinan Altan
authors.initials: SA
authors.lastname: Kocaman
authors.forename: Asife
authors.initials: A
authors.lastname: Sahinarslan
authors.forename: Uğur
authors.initials: U
authors.lastname: Arslan
authors.forename: Timur
authors.initials: T
authors.lastname: Timurkaynak
mesh_terms: D000241:Adenosine / Q000627:therapeutic use; D000368:Aged; D050197:Atherosclerosis / Q000175:diagnosis* / Q000503:physiopathology*; D003324:Coronary Artery Disease; D003331:Coronary Vessels / Q000503:physiopathology*; D005260:Female; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D007511:Ischemia / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000241:Adenosine