title: Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.
abstract: In order to study the effect of 5'-modification of 2'-deoxynucleoside on its anti-HCV activity, several analogues were synthesized and evaluated. Among the analogues, a 5'-deoxy-5'-phenacylated analogue exhibited a good anti-HCV activity with an EC(50) of 15.1 microM. This compound is expected to operate via a type of mechanism that does not involve a generally known 5'-O-triphosphorylation process.
authors.affiliation: Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan. ikejim@osaka-ohtani.ac.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ikejiri
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ohshima
authors.forename: Akemi
authors.initials: A
authors.lastname: Fukushima
authors.forename: Kunitada
authors.initials: K
authors.lastname: Shimotohno
authors.forename: Tokumi
authors.initials: T
authors.lastname: Maruyama
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004279:DNA, Viral / Q000378:metabolism; D003839:Deoxyadenosines / Q000737:chemistry* / Q000378:metabolism; D015195:Drug Design; D016174:Hepacivirus / Q000187:drug effects*; D006526:Hepatitis C / Q000188:drug therapy; D006801:Humans; D008956:Models, Chemical; D009705:Nucleosides / Q000737:chemistry; D010766:Phosphorylation; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D003839:Deoxyadenosines; D009705:Nucleosides; C058118:2'-deoxyadenosine