Lipid nanoparticles with a solid matrix (SLN, NLC, LDC) for oral drug delivery.
Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid-drug conjugates (LDC), commonly produced by high-pressure homogenization, are interesting vectors for oral delivery of lipophilic and, to a certain extent, hydrophilic substances. Their production can be done without the use of organic solvents. Techniques to make them a physically stable delivery system have been developed. Scaling up of the production process from lab-size to large-scale dimensions using high-pressure homogenization can be easily achieved by using a different type of homogenizer. The machines used for large-scale production often yield an even better product quality than the lab-scale types. This review article covers the methods of production, characterization, mechanisms of oral bioavailability enhancement, scale-up, final oral dosage forms, and regulatory aspects of lipid nanoparticles for oral drug delivery. It focuses mainly on high-pressure homogenization production methods.
Muchow
Marc
M
Laboratory of Pharmaceutical Technology and Biopharmacy, Universite Henri Poincare Nancy I, Nancy, France.
Maincent
Philippe
P
Muller
Rainer H
RH
D000284:Administration, Oral; D016503:Drug Delivery Systems; D007408:Intestinal Absorption; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D013678:Technology, Pharmaceutical
D008055:Lipids