Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways.
This review surveys efforts to reconstitute key steps in polyketide and nonribosomal peptide biosynthetic pathways with purified enzymes and substrates; 344 references are cited.
Sattely
Elizabeth S
ES
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.
Fischbach
Michael A
MA
Walsh
Christopher T
CT
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D016680:Genome, Bacterial; D018942:Macrolides / Q000378:metabolism*; D015394:Molecular Structure; D010453:Peptide Synthases / Q000235:genetics / Q000378:metabolism; D010455:Peptides / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D018942:Macrolides; D010455:Peptides; D010453:Peptide Synthases