5-HTTLPR genotype, stressful life events and late-life depression: no evidence of interaction in a French population.
Modification of the effect of life events on risk of depression by a polymorphism in the serotonin transporter gene promoter (5-HTTLPR) has been reported in child, adolescent, adult and elderly populations. Replication attempted on data collected from 1421 individuals aged 65 and over from a French community study provided no evidence of a similar modifying effect. In the only analysis known to the authors to be carried out in an exclusively elderly, European population, this null finding remained consistent after restriction of analysis to prevalent or incident cases.
Power
Tom
T
King's College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom.
Stewart
Robert
R
Ancelin
Marie-Laure
ML
Jaussent
Isabelle
I
Malafosse
Alain
A
Ritchie
Karen
K
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D000483:Alleles; D003863:Depression / Q000235:genetics*; D003866:Depressive Disorder / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005602:France; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008016:Life Change Events; D008297:Male; D011401:Promoter Regions, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D011795:Surveys and Questionnaires; D044465:White People / Q000235:genetics
D050486:Serotonin Plasma Membrane Transport Proteins