title: Mast cell activation by myelin through scavenger receptor.
abstract: A role for mast cells (MC) in the pathogenesis of multiple sclerosis (MS) has been suggested, based on the analysis of human lesions and on an animal model of the disease (EAE). What role MC play in the development of MS is not well understood. We hypothesized that the link connecting MC with demyelinating diseases may be represented by their interaction with myelin. Here we show that myelin can activate mast cells. This process could be a key event in the mast cell function required for inducing EAE in mice and possibly in MS in man.
authors.affiliation: Department of Physiology and Pathology, University of Trieste, via A. Fleming 22, 34127 Trieste Italy.
authors.forename: Nevenka
authors.initials: N
authors.lastname: Medic
authors.forename: Francesca
authors.initials: F
authors.lastname: Vita
authors.forename: Rita
authors.initials: R
authors.lastname: Abbate
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Soranzo
authors.forename: Sabrina
authors.initials: S
authors.lastname: Pacor
authors.forename: Elsa
authors.initials: E
authors.lastname: Fabbretti
authors.forename: Violetta
authors.initials: V
authors.lastname: Borelli
authors.forename: Giuliano
authors.initials: G
authors.lastname: Zabucchi
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology; D002478:Cells, Cultured; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008854:Microscopy, Electron / Q000379:methods; D009185:Myelin Proteins / Q000494:pharmacology; D009186:Myelin Sheath / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism / Q000648:ultrastructure; D009836:Oligodendroglia / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D051116:Receptors, Scavenger / Q000502:physiology*; D013481:Superoxides / Q000378:metabolism; D013997:Time Factors; D000267:Tissue Adhesions / Q000378:metabolism
chemical_list: D009185:Myelin Proteins; D051116:Receptors, Scavenger; D013481:Superoxides