The effect of 2'-fluorine substitutions on DNA i-motif conformation and stability.
(1)H and (19)F NMR, and UV thermal melting studies have established that the stability of d(TCCCCC) is enhanced by the inclusion of a single 2'-fluorine-modified deoxycytidine residue; the results support the notion of the importance of sugar-sugar contacts in stabilising i-motifs in general and reveal that solvation is the cause of the instability of RNA equivalents.
Fenna
Clare P
CP
School of Chemistry, University of Leeds, Leeds, UK LS2 9JT.
Wilkinson
Victoria J
VJ
Arnold
John R P
JR
Cosstick
Richard
R
Fisher
Julie
J
D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D005461:Fluorine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D012997:Solvents / Q000737:chemistry; D044366:Transition Temperature
D012997:Solvents; D005461:Fluorine; D004247:DNA