Aqueous microwave chemistry: a clean and green synthetic tool for rapid drug discovery.
The development of "Greener Organic Chemistry" is due to the recognition that environmentally friendly products and processes will be economical in the long term as they circumvent the need for treating 'end-of-the-pipe' pollutants and by-products generated by conventional synthesis. The fundamentals and significant outcomes of microwave-assisted organic synthesis in aqueous medium are summarized in this tutorial review, which have resulted in the development of relatively sustainable and environmentally benign protocols for the synthesis of drugs and fine chemicals.
Polshettiwar
Vivek
V
Sustainable Technology Division, National Risk Management Research Laboratory, US Environmental Protection Agency, Cincinnati, Ohio 45268, USA. vivekpol@yahoo.com
Varma
Rajender S
RS
D003247:Conservation of Natural Resources / Q000379:methods*; D015195:Drug Design; D008872:Microwaves; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry; D013997:Time Factors; D014867:Water / Q000737:chemistry*
D009930:Organic Chemicals; D014867:Water