[Experimental study of the effects of citalopram, olanzapine, and their combinations in tests for antipsychotic, antidepressant and anxiolytic activities of drugs].
The effects of citalopram, olanzapine and their combinations were studied in tests on outbred SHR male mice. The locomotor activity was determined in the open field, the antidepressant effects - in the tail suspension test, the anxiety-like behavior- in the light-dark transition test; in addition, the antidopaminergic effects of drugs and their combination were evaluated using the apomorphine-induced stereotypy. The results indicate that olanzapine inhibits locomotor activity in all behavioral tests, whereas citalopram alone has no significant effect and does not modify the action of olanzapine. An antagonistic interaction between drugs was revealed in tests for the specific antidepressant-like and antidopaminergic activity when citalopram/olanzapine combinations were used. No significant drug influence was observed on the anxiety-related mice behavior in the light/dark test.
Kozlovskiĭ
V L
VL
Kenunen
O G
OG
Khrabrova
A V
AV
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000928:Antidepressive Agents / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology*; D015283:Citalopram / Q000494:pharmacology*; D004347:Drug Interactions; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D000077152:Olanzapine
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D015283:Citalopram; D001569:Benzodiazepines; D001058:Apomorphine; D000077152:Olanzapine