title: [The results of cytogenetic analyses in prenatal diagnosis].
abstract: BACKGROUND
  G-banding and other classical cytogenetic methods are still in use, together with molecular cytogenetic techniques such as FISH (Fluorescence In Situ Hybridization) and SKY (Spectral Karyotyping).
  
  
  METHODS
  This retrospective study evaluated clinical data on individuaols seeking genetic counseling over a 15-year period (1992 - 2007) at the Medical Genetic Center, Child and Youth Health Care Institute of Vojvodina in Novi Sad. The study included 37.191 genetic counselings, and 20.607 prenatal analyses (amniocentesis and cordocentesis).
  
  
  RESULTS
  Over a 15-year period (1992 - 2007) 17.937 amniotic fluid samples were analyzed and 274 abnormal karyotypes were found; out of 2.670 fetal blood samples, there were 78 abnormal karyotypes. During a 15-year period, prenatal diagnosis, using amniocentesis and/or cordocentesis, showed 352 fetuses with chromosomal aberrations.
  
  
  CONCLUSIONS
  On average, over the past 15-year period, 8% of pregnancies were controlled with invasive prenatal procedures. The percentage has changed; in fact, it is increasing from year to year. In 1992, only 0.82% (N=139/17000) of pregnant women in Vojvodina underwent invasive prenatal procedures, and in 2006 the rate increased to 15.65% (N=2660/17000).
  
  
  CONCLUSIONS
  It is necessary to improve and promote the possibilities of genetic counseling and invasive prenatal diagnosis in order to prevent the occurrence of chromosomal aberrations and other genetic diseases.
authors.affiliation: Centar za medicinsku genetiku, Institut za zdravstvenu zastitu dece i omladine Vojvodine, Novi Sad.
authors.forename: Jadranka
authors.initials: J
authors.lastname: Jovanović-Privrodski
authors.forename: Ivana
authors.initials: I
authors.lastname: Kavecan
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Krstić
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Gaćina
mesh_terms: D020732:Cytogenetic Analysis; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011296:Prenatal Diagnosis