Animal models of wound healing: utility in transgenic mice.
Transgenic and knockout mouse technology represents a powerful tool for exploring the molecular pathways behind the wound healing process. The design and utilization of mouse wound healing models must be approached mindful of limitations of both the transgenic technology and the models themselves in order to continue generating useful information from studies with transgenic mice. A battery of standard and impaired wound healing models, when used in a systematic and combinatorial fashion, should yield significant contributions to wound healing research.
Fang
Robert C
RC
Division of Plastic and Reconstructive Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, 675 N. St. Clair Street, Chicago, IL 60611, USA.
Mustoe
Thomas A
TA
D000818:Animals; D001672:Biocompatible Materials; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D023421:Models, Animal; D008954:Models, Biological; D012867:Skin / Q000473:pathology; D014945:Wound Healing
D001672:Biocompatible Materials