Antimicrobial resistance in Shigella species isolated in Dakar, Senegal (2004-2006).
From May 2004 to October 2006, a prospective study was carried out in Dakar, Senegal, to update information about the antimicrobial susceptibility of Shigella spp. isolated from stool specimens. Among the 165 non-duplicate strains collected, 81 (49%) were identified as Shigella flexneri, 75 (45%) as Shigella sonnei, 5 (3%) as Shigella boydii, and 4 (2%) as Shigella dysenteriae. Disk diffusion testing revealed that the majority of isolates were resistant to sulphonamides, trimethoprim-sulfamethoxazole, streptomycin, and tetracycline (respective overall resistance rates: 90, 90, 96, and 94%). More than half of the S. flexneri isolates were resistant to amoxicillin, amoxicillin-clavulanic acid, and chloramphenicol (respective resistance rates: 59, 58, and 52%), and almost all of the S. sonnei isolates were susceptible to these antimicrobials (respective resistance rates: 4, 1, and 4%). Only one isolate (belonging to the species S. sonnei) was resistant to nalidixic acid and displayed reduced susceptibility to ciprofloxacin.
Sire
Jean-Marie
JM
Laboratoire de Biologie Medicale, Institut Pasteur, Dakar, Senegal. sire@pasteur.sn.
Macondo
Edgard Adam
EA
Perrier-Gros-Claude
Jean-David
JD
Siby
Tidiane
T
Bahsoun
Ibrahim
I
Seck
Abdoulaye
A
Garin
Benoit
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D052978:Disk Diffusion Antimicrobial Tests; D024881:Drug Resistance, Bacterial; D004405:Dysentery, Bacillary / Q000453:epidemiology / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D006801:Humans; D007223:Infant; D008875:Middle Aged; D012675:Senegal / Q000453:epidemiology; D012760:Shigella / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification; D012761:Shigella boydii / Q000187:drug effects / Q000302:isolation & purification; D012762:Shigella dysenteriae / Q000187:drug effects / Q000302:isolation & purification; D012763:Shigella flexneri / Q000187:drug effects / Q000302:isolation & purification; D012764:Shigella sonnei / Q000187:drug effects / Q000302:isolation & purification; D013045:Species Specificity
D000900:Anti-Bacterial Agents