title: [Patient awakening from anesthesia was re-sedated by administration of flumazenil].
abstract: An 83-year-old female patient was managed in intensive care unit postoperatively with artificial ventilation and propofol-based sedation. On the second postoperative day, we tried to remove an endotracheal tube. Naloxone was administered to the patient for reversing the sedative effect of fentanyl infused intraoperatively. Her consciousness level was improved; however, subsequent administration of flumazenil induced hypnosis. Benzodiazepine-like partial agonistic effect of flumazenil might have enhanced residual hypnotic effect of propofol. Administration of flumazenil to the patient infused with propofol should be done cautiously for awakening the patient from anesthesia.
authors.affiliation: Intensive Care Unit of University Hospital, Hamamatsu University School of Medicine, Hamamatsu 431-3192.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Adachi
authors.forename: Katsumi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yukako
authors.initials: Y
authors.lastname: Obata
authors.forename: Matsuyuki
authors.initials: M
authors.lastname: Doi
authors.forename: Shigehito
authors.initials: S
authors.lastname: Sato
mesh_terms: D000369:Aged, 80 and over; D000762:Anesthesia Recovery Period; D004357:Drug Synergism; D005260:Female; D005442:Flumazenil / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000097:blood; D008874:Midazolam / Q000037:antagonists & inhibitors; D015742:Propofol / Q000008:administration & dosage / Q000097:blood
chemical_list: D006993:Hypnotics and Sedatives; D005442:Flumazenil; D008874:Midazolam; D015742:Propofol