title: Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography.
abstract: BACKGROUND
  Progression of recurrent hepatitis C is accelerated in liver transplant recipients, leading to special need of non-invasive validated methods to estimate liver fibrosis.
  
  
  OBJECTIVE
  To assess the efficacy of liver stiffness measurement by transient elastography (Fibroscan) and serum parameters in predicting fibrosis stage in HCV-infected transplant recipients.
  
  
  METHODS
  The correlation between liver fibrosis, assessed at liver histology on bioptic specimens obtained for clinical indications, and stiffness or clinico-serological indexes (Benlloch, APRI, Forns, Fibrotest and Doppler resistance index), was investigated in transplant recipients with recurrence of HCV chronic hepatitis. A total of 56 patients (of which 36 with all clinico-serological indexes), presenting with the following METAVIR fibrosis stage F1=38, F2=9, F3=8, F4=1, were enrolled in the study population. Differences between fibrosis stages were calculated by non-parametric analysis. The best cut-off for identifying significant fibrosis (F2-F4) was assessed by ROC curve analysis.
  
  
  RESULTS
  Stiffness (median and range) was 7.7 KPa (range 4.2-13.9) in F1 and 17.0KPa (range 6.8-36.3) in >or=F2 (p<0.001). A stiffness cut-off of 10.1 KPa revealed 94% Sensitivity, 89% Specificity, 81% PPV and 94% NPV in differentiating F1 from F2-F4. The area under the receiver operator curve in the assessment of fibrosis was significantly higher for Liver stiffness (AUROC 0.943) than for any of the other non-invasive indexes (AUROCs ranging 0.591-0.815).
  
  
  CONCLUSIONS
  Transient elastography of the liver provides good accuracy in identifying patients with significant fibrosis and performs better than non-invasive indexes based on clinico-serological parameters in transplant recipients.
authors.affiliation: Department of Internal Medicine and Gastroenterology, Division of Internal Medicine - Bolondi, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Corradi
authors.forename: F
authors.initials: F
authors.lastname: Piscaglia
authors.forename: S
authors.initials: S
authors.lastname: Flori
authors.forename: A
authors.initials: A
authors.lastname: D'Errico-Grigioni
authors.forename: F
authors.initials: F
authors.lastname: Vasuri
authors.forename: M R
authors.initials: MR
authors.lastname: Tamé
authors.forename: P
authors.initials: P
authors.lastname: Andreone
authors.forename: P
authors.initials: P
authors.lastname: Boni
authors.forename: A
authors.initials: A
authors.lastname: Gianstefani
authors.forename: L
authors.initials: L
authors.lastname: Bolondi
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional