title: Prevention and management of hypertrophic scars and keloids after burns in children.
abstract: Hypertrophic scars and keloids are challenging to manage, particularly as sequelae of burns in children in whom the psychologic burden and skin characteristics differ substantially from adults. Prevention of hypertrophic scars and keloids after burns is currently the best strategy in their management to avoid permanent functional and aesthetical alterations. Several actions can be taken to prevent their occurrence, including parental and children education regarding handling sources of fire and flammable materials, among others. Combination of therapies is the mainstay of current burn scar management, including surgical reconstruction, pressure therapy, silicon gels and sheets, and temporary garments. Other adjuvant therapies such as topical imiquimod, tacrolimus, and retinoids, as well as intralesional corticosteroids, 5-fluorouracil, interferons, and bleomycin, have been used with relative success. Cryosurgery and lasers have also been reported as alternatives. Newer treatments aimed at molecular targets such as cytokines, growth factors, and gene therapy, currently in developing stages, are considered the future of the treatment of postburn hypertrophic scars and keloids in children.
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA. bberman@med.miami.edu
authors.forename: Brian
authors.initials: B
authors.lastname: Berman
authors.forename: Martha H
authors.initials: MH
authors.lastname: Viera
authors.forename: Sadegh
authors.initials: S
authors.lastname: Amini
authors.forename: Ran
authors.initials: R
authors.lastname: Huo
authors.forename: Isaac S
authors.initials: IS
authors.lastname: Jones
mesh_terms: D000293:Adolescent; D002056:Burns / Q000150:complications* / Q000534:rehabilitation / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D017439:Cicatrix, Hypertrophic / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D003286:Contracture / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D062109:Dermatologic Surgical Procedures; D006801:Humans; D007223:Infant; D007627:Keloid / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D012867:Skin / Q000293:injuries / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology