Model for the unidirectional motion of a dynein molecule.
Cytoplasmic dyneins transport cellular organelles by moving on a microtubule filament. It has been found recently that depending on the applied force and the concentration of the adenosine triphosphate molecules, dynein's step size varies. Based on these studies, we propose a simple model for dynein's unidirectional motion taking into account the variations in its step size. We study how the average velocity and the relative dispersion in the displacement vary with the applied load. The model is amenable to further extensions by inclusion of details associated with the structure and the processivity of the molecule.
Mukherji
Sutapa
S
Department of Physics, Indian Institute of Technology, Kanpur 208016, India.
D001665:Binding Sites; D003198:Computer Simulation; D004398:Dyneins / Q000737:chemistry* / Q000648:ultrastructure*; D008870:Microtubules / Q000737:chemistry* / Q000648:ultrastructure*; D008956:Models, Chemical; D008958:Models, Molecular; D020409:Molecular Motor Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D009038:Motion; D011485:Protein Binding; D011487:Protein Conformation
D020409:Molecular Motor Proteins; D004398:Dyneins