title: Leptin, soluble leptin receptor, lipid profiles, and LEPR gene polymorphisms in Thai children and adolescents.
abstract: OBJECTIVE
  To evaluate the relationships between leptin, soluble leptin receptor, lipid profiles, and LEPR gene polymorphisms in child and adolescent Thai subjects.
  
  
  METHODS
  Cross-sectional study of Thai children and adolescents.
  
  
  METHODS
  116 male and 65 female at risk for overweight/overweight child and adolescent Thai subjects, and 33 male and 62 female healthy child and adolescent Thai subjects (age: 5-19 years).
  
  
  METHODS
  Leptin levels, soluble leptin receptor levels, lipid profiles, LEPR gene polymorphisms.
  
  
  RESULTS
  Significantly higher levels of cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), and leptin levels were observed in at risk for overweight/overweight group. On the other hand, high-density lipoprotein cholesterol (HDL-C) and soluble leptin receptor levels were significantly lower in the same group. Serum soluble leptin receptor levels were significantly negatively correlated with leptin. The at risk for overweight/overweight subjects with the Lys656Lys homozygous wild type LEPR gene had significantly higher cholesterol and LDL-C levels than those with Lys656Asn heterozygous and Asn656Asn homozygous mutant type. In contrast, subjects with Lys656Lys homozygous wild type had significantly lower leptin levels than those with Lys656Asn heterozygous and Asn656Asn homozygous mutant type. There was a statistically significant association between body mass index (BMI) and hyperleptinemia (odds ratio; OR = 2.49, p = 0.000) and females had more increased risk of hyperleptinemia than males (OR = 15.74, p = 0.004) in adolescent Thai subjects.
  
  
  CONCLUSIONS
  The present study is the first report of Lys656Asn polymorphism of the LEPR gene associated with cholesterol, LDL-C, and leptin levels in Thai children and adolescents. Serum leptin levels were significantly higher in the at risk for overweight/overweight. In contrast, there were significantly lower soluble leptin receptor levels in the same group. In addition, there was a statistically significant association between BMI, sex, and hyperleptinemia in adolescent Thai subjects.
authors.affiliation: Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: Supaluk
authors.initials: S
authors.lastname: Popruk
authors.forename: Rungsunn
authors.initials: R
authors.lastname: Tungtrongchitr
authors.forename: Songsak
authors.initials: S
authors.lastname: Petmitr
authors.forename: Praneet
authors.initials: P
authors.lastname: Pongpaew
authors.forename: Talabporn
authors.initials: T
authors.lastname: Harnroongroj
authors.forename: Somchai
authors.initials: S
authors.lastname: Pooudong
authors.forename: Benjaluck
authors.initials: B
authors.lastname: Phonrat
authors.forename: Uruwan
authors.initials: U
authors.lastname: Yamborisut
authors.forename: Nalinee
authors.initials: N
authors.lastname: Chongviriyaphan
authors.forename: Anchalee
authors.initials: A
authors.lastname: Tungtrongchitr
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood / Q000235:genetics; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000235:genetics; D020738:Leptin / Q000097:blood* / Q000235:genetics; D008055:Lipids / Q000097:blood* / Q000235:genetics; D008297:Male; D009765:Obesity / Q000097:blood / Q000235:genetics; D016017:Odds Ratio; D050177:Overweight / Q000097:blood / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D054411:Receptors, Leptin / Q000097:blood* / Q000235:genetics; D012307:Risk Factors; D017678:Sex Distribution; D013785:Thailand
chemical_list: C515448:LEPR protein, human; D020738:Leptin; D008055:Lipids; D054411:Receptors, Leptin; D002784:Cholesterol