title: Effect of synthetic dermorphin analogues on tissue homeostasis in the myocardium of newborn albino rats.
abstract: DNA synthesis and state of the nucleolar apparatus in myocardial cells of newborn albino rats receiving intraperitoneal injection of sedatin, a synthetic dermorphin analogue, were studied by means of autoradiography and silver impregnation. Labeling intensity significantly increased, while the number of nucleoli in nuclei decreased. Chemiluminescence study showed that the concentration of reactive oxygen metabolites significantly decreased in the myocardium of treated animals after sedatin administration. Non-arginine analogue of sedatin had little effect on tissue homeostasis in the myocardium.
authors.affiliation: Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk.
authors.forename: S Yu
authors.initials: SY
authors.lastname: Kriganovskaya
authors.forename: O A
authors.initials: OA
authors.lastname: Lebed'ko
authors.forename: E N
authors.initials: EN
authors.lastname: Sazonova
authors.forename: S S
authors.initials: SS
authors.lastname: Timoshin
authors.forename: L E
authors.initials: LE
authors.lastname: Molokanova
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D006706:Homeostasis / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D049449:Luminescence; D009206:Myocardium / Q000378:metabolism*; D009842:Oligopeptides / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D018847:Opioid Peptides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
chemical_list: D009842:Oligopeptides; D018847:Opioid Peptides; C493049:sedatin; C030058:dermorphin