A light-gated synthetic ion channel.
A gated synthetic ion channel with beta-cyclodextrin as the pore and azobenzene as the gate is reported. Irradiation converts a tethered trans-azobenzene to cis-azobenzene which likely transforms the channel from a self-inclusion complex to a dissociated structure. This transformation results in an increase in anion transport and a decrease in cation transport across a phospholipid vesicle membrane.
Jog
Parag V
PV
Roger Adams Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Gin
Mary S
MS
D001391:Azo Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D015640:Ion Channel Gating / Q000528:radiation effects; D007473:Ion Channels / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D010743:Phospholipids / Q000737:chemistry; D010777:Photochemistry; D014466:Ultraviolet Rays; D047392:beta-Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*
D001391:Azo Compounds; D007473:Ion Channels; D010743:Phospholipids; D047392:beta-Cyclodextrins; C009850:azobenzene