Bendigoles A approximately C, new steroids from Gordonia australis Acta 2299.
Bendigoles A approximately C are the first secondary metabolites to be isolated from a member of the actinomycete genus Gordonia. They were detected in a culture filtrate extract of Gordonia australis Acta 2299 by HPLC-diode array analysis and characterized as new steroids by mass spectrometry and NMR experiments. Bendigole C show binding affinity to the human progesterone and A approximately C to androgen receptor but are inactive at mineralocorticoid and estrogen receptors. In in vitro transactivation studies bendigoles A and C showed moderate and weak androgenic activities.
Schneider
Kathrin
K
Institut für Chemie, Technische Universität Berlin, Germany.
Graf
Ellen
E
Irran
Elisabeth
E
Nicholson
Graeme
G
Stainsby
Fiona M
FM
Goodfellow
Michael
M
Borden
Steffen A
SA
Keller
Simone
S
Süssmuth
Roderich D
RD
Fiedler
Hans-Peter
HP
D000728:Androgens / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D005285:Fermentation; D033601:Gordonia Bacterium / Q000145:classification / Q000254:growth & development / Q000378:metabolism*; D006801:Humans; D006914:Hydroxysteroids / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011374:Progesterone / Q000378:metabolism; D011944:Receptors, Androgen / Q000378:metabolism; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism; D018161:Receptors, Mineralocorticoid / Q000187:drug effects / Q000378:metabolism
D000728:Androgens; D006914:Hydroxysteroids; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D018161:Receptors, Mineralocorticoid; C532987:bendigole A; C532988:bendigole B; C532989:bendigole C; D011374:Progesterone