Assessment by time-kill methodology of the synergistic effects of oritavancin in combination with other antimicrobial agents against Staphylococcus aureus.
Oritavancin is a semisynthetic lipoglycopeptide in clinical development for serious gram-positive infections. This study describes the synergistic activity of oritavancin in combination with gentamicin, linezolid, moxifloxacin, or rifampin in time-kill studies against methicillin-susceptible, vancomycin-intermediate, and vancomycin-resistant Staphylococcus aureus.
Belley
Adam
A
Targanta Therapeutics Incorporated, 7170 Frederick Banting, St. Laurent, Quebec, Canada.
Neesham-Grenon
Eve
E
Arhin
Francis F
FF
McKay
Geoffrey A
GA
Parr
Thomas R
TR
Moeck
Gregory
G
D000081:Acetamides / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001372:Aza Compounds / Q000008:administration & dosage; D004357:Drug Synergism; D024841:Fluoroquinolones; D005839:Gentamicins / Q000008:administration & dosage; D006020:Glycopeptides / Q000008:administration & dosage*; D006801:Humans; D000069349:Linezolid; D000077427:Lipoglycopeptides; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests / Q000379:methods; D000077266:Moxifloxacin; D023303:Oxazolidinones / Q000008:administration & dosage; D011136:Polysorbates; D011804:Quinolines / Q000008:administration & dosage; D012293:Rifampin / Q000008:administration & dosage; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013501:Surface-Active Agents; D020713:Vancomycin Resistance; D014640:Vancomycin / Q000031:analogs & derivatives
D000081:Acetamides; D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D005839:Gentamicins; D006020:Glycopeptides; D000069349:Linezolid; D000077427:Lipoglycopeptides; D000077266:Moxifloxacin; D023303:Oxazolidinones; D011136:Polysorbates; D011804:Quinolines; D012293:Rifampin; D013501:Surface-Active Agents; C100708:oritavancin; D014640:Vancomycin