Integrins: the keys to unlocking angiogenesis.
Angiogenesis, the formation of new blood vessels from preexisting vasculature, contributes to the pathogenesis of many disorders, including ischemic diseases and cancer. Integrins are cell adhesion molecules that are expressed on the surface of endothelial cells and pericytes, making them potential targets for antiangiogenic therapy. Here we review the contribution of endothelial and mural cell integrins to angiogenesis and highlight their potential as antiangiogenesis targets.
Silva
Rita
R
Adhesion and Angiogenesis Group, Centre for Tumour Biology, Cancer Research UK Clinical Centre, Institute of Cancer, Barts &The London & Queen Mary's School of Medicine & Dentistry, John Vane Science Centre, Charterhouse Square, London UK.
D'Amico
Gabriela
G
Hodivala-Dilke
Kairbaan M
KM
Reynolds
Louise E
LE
D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000187:drug effects; D020286:Pericytes / Q000378:metabolism; D038981:Receptors, Collagen / Q000378:metabolism; D017469:Receptors, Fibronectin / Q000378:metabolism; D017474:Receptors, Laminin / Q000378:metabolism; D019030:Receptors, Vitronectin / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
D020533:Angiogenesis Inhibitors; D016023:Integrins; D038981:Receptors, Collagen; D017469:Receptors, Fibronectin; D017474:Receptors, Laminin; D019030:Receptors, Vitronectin