Central prostaglandins in food intake regulation.
Prostaglandin (PG) E(2) and PGD(2), produced in the mammalian central nervous system, are known to have a variety of central actions on sleep, body temperature, and pain response via G-protein-coupled seven-transmembrane receptors. We found that centrally administered PGE(2) suppressed food intake via the EP(4) receptor, whereas PGD(2) increased food intake via the DP(1) receptor coupled to the neuropeptide Y Y(1) receptor. In this review, we summarize roles of central PGs in food intake regulation and discuss the relation between PGs and neuropeptides controlling food intake.
Ohinata
Kousaku
K
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan. ohinata@kais.kyoto-u.ac.jp
Yoshikawa
Masaaki
M
D000818:Animals; D001069:Appetite Regulation / Q000502:physiology; D004435:Eating / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D051379:Mice; D009479:Neuropeptides / Q000378:metabolism / Q000494:pharmacology; D011453:Prostaglandins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*
D009479:Neuropeptides; D011453:Prostaglandins