Association of localized intravascular coagulopathy with venous malformations.
OBJECTIVE
To determine which venous malformations (VMs) are at risk for coagulopathy. Venous malformations are slow-flow vascular malformations present at birth, and localized intravascular coagulopathy (LIC) causes pain and thrombosis within a lesion and severe bleeding during surgical procedures.


METHODS
Prospective convenience sample accrued from 2 multidisciplinary sites in Brussels, Belgium, and Caen, France.


METHODS
The study population comprised 140 patients with clinical data and coagulation parameters. Magnetic resonance imaging was performed for 110 patients.


METHODS
Measurement of D-dimer levels.


RESULTS
Of the 140 participants, 59 (42%) showed high D-dimer levels, 36 (61%) of whom had levels higher than 1.0 microg/mL. Six of the participants had low fibrinogen levels. In univariate analysis, large surface, presence of palpable phleboliths, and truncal localization were associated with high D-dimer levels. In the multivariate analysis, only large surface area and presence of phleboliths remained independently associated with high D-dimer levels. Severe LIC, characterized by concomitant low fibrinogen level, was associated with extensive venous malformations of the extremities.


CONCLUSIONS
Localized intravascular coagulopathy is statistically significantly associated with large and/or deep venous malformations that affect any location, which can have a palpable phlebolith. These patients are at risk of local pain due to thrombosis. Lesions with elevated D-dimer levels associated with low fibrinogen levels (severe LIC) commonly affect an extremity and have a high risk of hemorrhage. Low-molecular-weight heparin can be used both to treat the pain caused by LIC and to prevent decompensation of severe LIC to disseminated intravascular coagulopathy.
Dompmartin
Anne
A
Department of Dermatology, Université de Caen Basse Normandie, Centre Hospitalier Universitaire Caen, Caen, France.
Acher
Aurélie
A
Thibon
Pascal
P
Tourbach
Sébastien
S
Hermans
Cédric
C
Deneys
Véronique
V
Pocock
Ben
B
Lequerrec
Agnès
A
Labbé
Daniel
D
Barrellier
Marie-Thérèse
MT
Vanwijck
Romain
R
Vikkula
Miikka
M
Boon
Laurence M
LM
D000293:Adolescent; D000328:Adult; D000368:Aged; D001530:Belgium / Q000453:epidemiology; D001778:Blood Coagulation Disorders / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005602:France / Q000453:epidemiology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D014463:Ultrasonography; D054079:Vascular Malformations / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000473:pathology
D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D