title: Neuropsychiatric involvement in juvenile systemic lupus erythematosus.
abstract: Neuropsychiatric involvement is an important cause of morbidity and mortality in systemic lupus erythematosus (SLE) and it has been reported to occur in 22-95% of the childhood SLE patients. The aim of this study was to evaluate the neuropsychiatric involvement in our juvenile SLE patients. This was a cross-sectional assessment of patients to investigate the relationship between the involvement of the nervous system and the clinical factors, including autoantibodies, renal involvement and disease activity. We used Symptom Checklist-90-R (SCL-90-R), designed to measure the psychopathological symptoms. As controls, we used 20 healthy adolescents and 20 patients with chronic diseases without any neuropsychiatric manifestations. Overall, 55% (n= 11) of the patients displayed neurological symptoms and/or signs. However, central nervous system (CNS) imaging showed pathological findings only in four of these patients. Patients with headache only had normal CNS imaging. Nine patients had moderate to severe depression. When SLE patients were compared to healthy controls and to adolescents with chronic diseases, they were found to be significantly more depressed. In conclusion, pediatric rheumatologists should be aware of the frequency of neuropsychiatric disturbances in SLE. The neuropsychiatric disorders do not always correlate with disease activity and these children need professional psychological evaluation.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Demirkaya
authors.forename: Yelda
authors.initials: Y
authors.lastname: Bilginer
authors.forename: Nuray
authors.initials: N
authors.lastname: Aktay-Ayaz
authors.forename: Dilek
authors.initials: D
authors.lastname: Yalnizoğlu
authors.forename: Kader
authors.initials: K
authors.lastname: Karli-Oğuz
authors.forename: Vedat
authors.initials: V
authors.lastname: Işikhan
authors.forename: Türker
authors.initials: T
authors.lastname: Türker
authors.forename: Rezan
authors.initials: R
authors.lastname: Topaloğlu
authors.forename: Nesrin
authors.initials: N
authors.lastname: Beşbaş
authors.forename: Ayşin
authors.initials: A
authors.lastname: Bakkaloğlu
authors.forename: Seza
authors.initials: S
authors.lastname: Ozen
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D003863:Depression / Q000209:etiology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000523:psychology; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology*