The imaging of apoptosis with the radiolabelled annexin A5: a new tool in translational research.
Programmed cell death also called apoptosis plays a pivotal role in many physiological and pathological conditions. In the multi-step process of drug development, a number of medications are being designed to target strategic checkpoints of the apoptotic cascade either to induce or to inhibit programmed cell death. Conceptually, the assessment of programmed cell death in response to various therapeutic interventions appears to be critical for evaluating the efficacy of many drugs that act through apoptotic pathways. In the last decade, nuclear medicine techniques provided proofs of principle for the imaging of apoptosis both in vitro and in vivo. The purpose of this article was to review current knowledge on the imaging of apoptosis with radiolabelled annexin A5 in various pre-clinical and clinical models, and beyond that, to assess the potential integration of such a dedicated technology into translational research.
Belhocine
Tarik Z
TZ
Department of Diagnostic Radiology and Nuclear Medicine, St. Joseph's Hospital, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada. tarikbelhocine@yahoo.fr
Blankenberg
Francis G
FG
D000818:Animals; D017304:Annexin A5 / Q000493:pharmacokinetics; D017209:Apoptosis; D006801:Humans; D015609:Organotechnetium Compounds; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D011994:Recombinant Proteins; D015899:Tomography, Emission-Computed, Single-Photon
D017304:Annexin A5; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D011994:Recombinant Proteins