Synthesis of amides of 2,4-dioxothiazolidin-5-yl acetic acid with 1,2,4-triazole substituents.
In the reaction of (2,4-dioxothiazolidin-5-yl)acetyl chloride with 1,2,4-triazole, 4-phenyl-1,2,4-triazolin-5-one and 4-phenyl-1,2,4-triazolin-5-thione, the new corresponding amides (2-4) were obtained. For compounds 2 and 4 effects on central nervous system (CNS) of mice were studied.
Trotsko
Nazar
N
Department of Organic Chemistry, Medical University, 6 Staszica Str., 20-081 Lublin, Poland. nazar.trotsko@am.lublin.pl
Dobosz
Maria
M
Chodkowska
Anna
A
Jagiełło-Wójtowicz
Ewa
E
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D053778:Thiazolidines / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
D000577:Amides; D002491:Central Nervous System Agents; D053778:Thiazolidines; D014230:Triazoles