title: Natural inhibitors of DNA topoisomerase I with cytotoxicities.
abstract: DNA Topoisomerase I can cause DNA breaks and play a key role during cell proliferation and differentiation. It is an important target for anticancer agents. While screening for anticancer compounds, seven natural compounds, 1-7, showed potent cytotoxicities against a panel of ten cancer cell lines. Moreover, an inhibition assay demonstrated that they are also DNA topoisomerase I inhibitors, in which inhibitors 1-5 are new ones.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China.
authors.forename: Hong-Jin
authors.initials: HJ
authors.lastname: Han
authors.forename: Ning-Hua
authors.initials: NH
authors.lastname: Tan
authors.forename: Guang-Zhi
authors.initials: GZ
authors.lastname: Zeng
authors.forename: Jun-Ting
authors.initials: JT
authors.lastname: Fan
authors.forename: Huo-Qiang
authors.initials: HQ
authors.lastname: Huang
authors.forename: Chang-Jiu
authors.initials: CJ
authors.lastname: Ji
authors.forename: Rui-Rui
authors.initials: RR
authors.lastname: Jia
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
authors.forename: Ying-Jun
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
authors.forename: Li-Qin
authors.initials: LQ
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D059004:Topoisomerase I Inhibitors
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D059004:Topoisomerase I Inhibitors