Mortality secondary to fulminant hepatic failure in patients with prior resolution of hepatitis B virus infection in Japan.
Hepatitis B virus (HBV) reactivation in patients with resolved HBV infection was found in 23 (4%) of 552 newly hepatitis B surface antigen-positive patients in Japan. Because one-fourth of cases develop into fulminant hepatic failure and mortality is 100%, management of HBV reactivation in patients with resolved HBV infection should be discussed.
Umemura
Takeji
T
Department of Internal Medicine, Hepatology, and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan. tumemura@shinshu-u.ac.jp
Tanaka
Eiji
E
Kiyosawa
Kendo
K
Kumada
Hiromitsu
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007564:Japan / Q000453:epidemiology; D017114:Liver Failure, Acute / Q000453:epidemiology / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014775:Virus Activation; D055815:Young Adult
D000998:Antiviral Agents