Fatal-stroke syndrome revealing fungal cerebral vasculitis due to Arthrographis kalrae in an immunocompetent patient.
We report an uncommon clinical presentation of a unique case of fatal invasive fungal cerebral vasculitis due to Arthrographis kalrae in a nonimmunocompromised host. The identity of the fungus was determined by morphological characteristics and by analysis of internal transcribed spacer 1 sequences and was confirmed by postmortem examination of the brain tissues. Establishing rapidly the link between the clinical syndromes and the fungal infection of the central nervous system is essential to improve the outcome. As our case has shown, it is more challenging to make a diagnosis of fungal infection when there are no risk factors of immunodeficiency and when the clinical presentation seems uncommon.
Pichon
N
N
Medical-Surgical Intensive Care Unit, Dupuytren University Hospital, Limoges Cedex, France. nicolas.pichon@chu-limoges.fr
Ajzenberg
D
D
Desnos-Ollivier
M
M
Clavel
M
M
Gantier
J C
JC
Labrousse
F
F
D000328:Adult; D001203:Ascomycota; D020314:Central Nervous System Fungal Infections / Q000382:microbiology*; D006801:Humans; D008297:Male; D020521:Stroke / Q000382:microbiology; D013577:Syndrome; D020293:Vasculitis, Central Nervous System / Q000382:microbiology*