title: Humphrey matrix frequency doubling perimetry for detection of visual-field defects in open-angle glaucoma.
abstract: OBJECTIVE
  Matrix perimetry uses frequency-doubling technology (FDT) incorporated into a 5 degrees test target. This permits testing of the same number of locations within a defined visual field as standard automated perimetry (SAP) and may improve performance compared with original FDT perimetry. This study investigates the performance of Humphrey Matrix perimetry for detecting glaucomatous visual-field loss.
  
  
  METHODS
  Prospective case control study.
  
  
  METHODS
  We recruited 115 participants with glaucomatous visual-field loss and 33 normal controls from an urban glaucoma practice. Each participant performed SITA 24-2 SAP then threshold 24-2 Matrix perimetry. Severity of visual-field loss was defined using SAP mean deviation (MD) as early (MD >-6 dB), moderate (MD -6 to -12 dB) or advanced (MD <-12 dB). The sensitivity and specificity of Humphrey Matrix perimetry were calculated for different automated indices.
  
  
  RESULTS
  The matrix perimetry sensitivity and specificity were up to 100% for moderate and advanced glaucomatous visual-field loss. A receiver operator characteristic area under the curve (AUC) analysis revealed MD to be slightly better than pattern standard deviation (PSD) for defining moderate (AUC: MD 0.997; PSD 0.987) and advanced defects (AUC: MD 1.000; PSD 0.987). Matrix was less sensitive (up to 87.3%) for detecting early glaucomatous visual-field loss compared with SITA 24-2 SAP (AUC: PSD 0.948; MD 0.910).
  
  
  CONCLUSIONS
  Matrix perimetry is excellent for detection of moderate to advanced glaucomatous visual-field loss but may miss some early defects. It may be well suited to following progression of early to moderate field loss because of a smaller target size compared with original FDT perimetry.
authors.affiliation: Sydney Eye Hospital, Sydney, Australia. colinc1@gmp.usyd.edu.au
authors.forename: C I
authors.initials: CI
authors.lastname: Clement
authors.forename: I
authors.initials: I
authors.lastname: Goldberg
authors.forename: P R
authors.initials: PR
authors.lastname: Healey
authors.forename: S
authors.initials: S
authors.lastname: Graham
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields