Polychlorinated compounds with PPAR-gamma agonistic effect from the medicinal fungus Phellinus ribis.
During the search for natural substances with PPAR-gamma agonistic effect, unique polychlorinated compounds named chlorophellins A-C have been isolated together with the known compound, drosophilin A, from the methanolic extract of the fruiting body of the fungus Phellinus ribis. Their structures were assigned on the basis of NMR and mass spectrometric analyses. Chlorophellin C of compounds tested exhibited the most potent PPAR-gamma agonistic effect and was comparable to rosiglitazone, a well-known PPAR-gamma agonist that has been used for the therapy of type 2 diabetes.
Lee
In-Kyoung
IK
Functional Metabolites Research Center, KRIBB, 111 Gwahangno, Yuseong-gu, Daejeon 305-806, Republic of Korea.
Lee
Jeong-Hyung
JH
Yun
Bong-Sik
BS
D000840:Anisoles / Q000737:chemistry; D000890:Anti-Infective Agents / Q000494:pharmacology; D002713:Chlorine / Q000737:chemistry*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004224:Diterpenes / Q000737:chemistry; D005658:Fungi / Q000378:metabolism*; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D000432:Methanol / Q000737:chemistry; D008956:Models, Chemical; D047495:PPAR gamma / Q000819:agonists*; D010647:Phenyl Ethers / Q000737:chemistry; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology
D000840:Anisoles; D000890:Anti-Infective Agents; D004224:Diterpenes; D006843:Hydrocarbons, Chlorinated; D047495:PPAR gamma; D010647:Phenyl Ethers; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D002713:Chlorine; D000432:Methanol