title: Circulating 20S proteasome levels in patients with mixed connective tissue disease and systemic lupus erythematosus.
abstract: The associations of circulating 20S proteasomes (c20S) with clinical and serologic disease indices in patients with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD) are unknown. We present the initial report that c20S levels are elevated in MCTD and correlate with clinically relevant changes in disease activity in SLE and MCTD.
authors.affiliation: The Burn and Shock Trauma Institute and Department of Surgery, Loyola University Chicago Stritch School of Medicine, Chicago, Illinois, USA.
authors.forename: Matthias
authors.initials: M
authors.lastname: Majetschak
authors.forename: Magdalena
authors.initials: M
authors.lastname: Perez
authors.forename: Luis T
authors.initials: LT
authors.lastname: Sorell
authors.forename: Janet
authors.initials: J
authors.lastname: Lam
authors.forename: Marcos E
authors.initials: ME
authors.lastname: Maldonado
authors.forename: Robert W
authors.initials: RW
authors.lastname: Hoffman
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000503:physiopathology*; D046988:Proteasome Endopeptidase Complex / Q000097:blood*; D013223:Statistics as Topic
chemical_list: D046988:Proteasome Endopeptidase Complex