A review of critical factors in the conduct and interpretation of the human repeat insult patch test.
This paper reviews key factors that are critical to the conduct and interpretation of Human Repeat Insult Patch Tests (HRIPTs). A methodology for HRIP testing is described and general guidelines for evaluation of responses indicative of induction and elicitation of skin sensitization and skin irritation are detailed. Understanding and applying these key factors is crucial to the design of such studies and reliability of the resulting data when used in the overall risk assessment process.
McNamee
Pauline M
PM
The Procter & Gamble Company, Whitehall Lane, Egham, Surrey TW209NW, UK. mcnamee.pm@pg.com
Api
Anne Marie
AM
Basketter
David A
DA
Frank Gerberick
G
G
Gilpin
Deborah A
DA
Hall
Barbara M
BM
Jowsey
Ian
I
Robinson
Michael K
MK
D000818:Animals; D003257:Consumer Product Safety; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D017408:Guidelines as Topic; D006801:Humans; D010328:Patch Tests / Q000379:methods*; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods