title: New visions for atopic eczema: an iPAC summary and future trends.
abstract: Atopic eczema (AE) is a chronic inflammatory skin disease characterized by pruritus, dry skin and an ongoing course of exacerbations and remissions. AE is a common disorder in children with a worldwide cumulative prevalence of 15-20% in this age group. AE has a strong familial predisposition. While AE is a complex disease with multiple gene involvement, recent interest has focused on genes involved in skin barrier/epidermal differentiation and in immune response/host defense. Recent developments and future directions on pathogenesis, diagnosis, natural course and prognosis are discussed.
authors.affiliation: Hôpital des Enfants, Toulouse, France. rance.f@chu-toulouse.fr
authors.forename: Fabienne
authors.initials: F
authors.lastname: Rancé
authors.forename: Mark
authors.initials: M
authors.lastname: Boguniewicz
authors.forename: Susanne
authors.initials: S
authors.lastname: Lau
mesh_terms: D002675:Child, Preschool; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D003876:Dermatitis, Atopic / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology* / Q000628:therapy; D003937:Diagnosis, Differential; D000091344:Filaggrin Proteins; D020022:Genetic Predisposition to Disease; D006801:Humans; D007073:Immunoglobulin E / Q000235:genetics / Q000276:immunology; D007223:Infant; D007381:Intermediate Filament Proteins / Q000235:genetics; D015995:Prevalence; D011379:Prognosis; D012879:Skin Physiological Phenomena
chemical_list: D016207:Cytokines; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D007073:Immunoglobulin E