title: Functional diversity of chitin synthases of Aspergillus nidulans in hyphal growth, conidiophore development and septum formation.
abstract: Fungal chitin synthases are classified into seven classes. Recent advances in genome sequence analyses have revealed that there are more than seven chitin synthase-encoding genes in the genome of filamentous ascomycete fungi. To clarify the functional differences among these genes in the morphogenesis and hyphal tip growth, we have cloned six chitin synthase-encoding genes from Aspergillus nidulans and analyzed their functions. The results obtained suggest that chitin synthases are structurally and functionally divergent and play crucial roles in the growth and morphogenesis of A. nidulans.
authors.affiliation: Department of Biotechnology, The University of Tokyo, Tokyo, Japan. ahhoriu@mail.ecc.u-tokyo.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Horiuchi
mesh_terms: D001233:Aspergillus nidulans / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development*; D002687:Chitin Synthase / Q000235:genetics / Q000378:metabolism*; D003001:Cloning, Molecular; D020869:Gene Expression Profiling; D025301:Hyphae / Q000201:enzymology* / Q000254:growth & development*; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D013172:Spores, Fungal / Q000201:enzymology / Q000254:growth & development
chemical_list: D002687:Chitin Synthase