Role of CD64, P53 and P21 proteins in the pathogenesis of the tubulo-interstitial syndrome in Masugi chronic nephritis.
Experiments of 42 outbred male albino rats (160-180 g) showed an increase in the content of CD64, fibroblast growth factor, and proapoptotic proteins (p53 and p21) in the renal cortical matter on day 45 of experimental chronic Masugi nephritis. A positive correlation between CD64 and fibroblast growth factor characterizes the macrophage-fibroblast interactions, the key point in the formation of tubulo-interstitial fibrosis.
Rogovyi
Yu E
YE
Department of Physiology, Bukovina State Medical University, Ministry of Health of the Ukraine, Chernovtsy.
Arkhipova
L G
LG
Dikal
M V
MV
Filipova
L O
LO
Mil'
E N
EN
D000818:Animals; D002908:Chronic Disease; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism* / Q000502:physiology; D004195:Disease Models, Animal; D005346:Fibroblast Growth Factors / Q000378:metabolism / Q000502:physiology; D008297:Male; D009393:Nephritis / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D009395:Nephritis, Interstitial / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017452:Receptors, IgG / Q000378:metabolism* / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism* / Q000502:physiology
D050759:Cyclin-Dependent Kinase Inhibitor p21; D017452:Receptors, IgG; D016159:Tumor Suppressor Protein p53; D005346:Fibroblast Growth Factors