A possible role of osteocalcin in the regulation of insulin secretion: human in vivo evidence?
Recent studies have indicated a novel function for skeleton unraveling its importance in the control of energy metabolism. In the present commentary, we speculate on the meaning for bone to act as a 'rheostat' modulating glucose metabolism, and how the primitive way of communication between bone and energy metabolism through switch on/off genes (like Ptprv) evolved to a more complicated 'talking' via gain/loss of hormones activity (like osteocalcin) by carboxylation/decarboxylation process.
Kassi
Eva
E
Department of Biological Chemistry, University of Athens Medical School, 75, Mikras Asias Street, 11527 Athens, Greece.
Papavassiliou
Athanasios G
AG
D001842:Bone and Bones / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D015675:Osteocalcin / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D007328:Insulin; D015675:Osteocalcin; D005947:Glucose