title: [Specific features of lactate dehydrogenase activity in blood and urine of males and females with renal carcinoma].
abstract: We studied activity of lactate dehydrogenase (LDG) in blood serum and urine of males and females with renal carcinoma as well as in healthy controls in various age groups for specification of LDG role for early diagnosis of the disease. We examined 101 patients with renal carcinoma (males 65.3%, females 34.7%, age 20-80 years, histological verification 98%) and 119 controls matched by gender, age and residence. LDG activity was determined by kinetic UV-test with a special kit. Statistic significance of the results was estimated using such indices as relative risk, confidence interval, two-sample t-test with various variances. Blood LDG was higher more often in 50--59 year old males and females, but differences with the control were not significant. Statistically significant elevation of LDG level in urine in males and insignificant one in females were observed. We believe that LDG activity test as an additional test for early diagnosis of renal carcinoma is justified both in males and females.
authors.forename: M B
authors.initials: MB
authors.lastname: Prianichnikova
authors.forename: O V
authors.initials: OV
authors.lastname: Zhurkina
authors.forename: A A
authors.initials: AA
authors.lastname: Gusev
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood* / Q000652:urine*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000097:blood* / Q000652:urine*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D014408:Biomarkers, Tumor; D007770:L-Lactate Dehydrogenase