title: Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia.
abstract: A new chromosome-carried quinolone resistance gene from Stenotrophomonas maltophilia, Smqnr, was characterized. The gene was present in type strain CCUG 5866 and was also detected in 24 clinical isolates and showed some allelic diversity. The expression of Smqnr in Escherichia coli decreased the susceptibilities of the E. coli isolates to several fluoroquinolones.
authors.affiliation: Department of Infection Control Science, Faculty of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Shimizu
authors.forename: Ken
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Sasaki
authors.forename: Namiko
authors.initials: N
authors.lastname: Takahashi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ohtsuka
authors.forename: Yuka
authors.initials: Y
authors.lastname: Ono
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hiramatsu
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D002876:Chromosomes, Bacterial / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D024841:Fluoroquinolones / Q000494:pharmacology*; D005798:Genes, Bacterial; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D020615:Stenotrophomonas maltophilia / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D017931:DNA Primers; D004269:DNA, Bacterial; D024841:Fluoroquinolones