title: Relationship between physical and genetic distances along the zebra finch Z chromosome.
abstract: Nine bacterial artificial chromosomes containing genes linked to the Z chromosome of the zebra finch (Taeniopygia guttata) were localized using FISH on synaptonemal complex spreads. Their positions were correlated with those previously reported on the mitotic Z chromosome, showing a linear relationship between positions along the mitotic chromosome and its synaptonemal complex. Distances in cM between the genes were calculated using a cytological map of the crossing-over based on the distribution of MLH1 foci along the ZZ synaptonemal complex (MLH1-cM map). It is shown that physical and genetic distances lack a linear relationship along most of the chromosome length, due to clustering of crossover events around the telomeres. This relationship departs strongly from that observed in the chicken Z chromosome and reflects the existence of different recombination rates and patterns among birds in spite of wide genomic conservation.
authors.affiliation: Instituto de Investigaciones en Reproducción, Universidad de Buenos Aires, Buenos Aires, Argentina. mpigozzi@fmed.uba.ar
authors.forename: María Inés
authors.initials: MI
authors.lastname: Pigozzi
mesh_terms: D000818:Animals; D002503:Centromere / Q000235:genetics; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics*; D046369:Finches / Q000235:genetics*; D023061:Gene Order; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008540:Meiosis; D008938:Mitosis; D009687:Nuclear Proteins / Q000235:genetics; D049471:Pachytene Stage; D020161:Physical Chromosome Mapping; D013094:Spermatozoa / Q000166:cytology; D013573:Synaptonemal Complex / Q000378:metabolism
chemical_list: D009687:Nuclear Proteins