title: Asymmetric addition of dimethylzinc to alpha-ketoesters catalyzed by (-)-MITH.
abstract: This investigation describes the catalytic asymmetric addition of dimethylzinc to alpha-ketoesters in the presence of (-)-MITH ( 5) and triethyl borate as an additive to give the corresponding chiral alpha-hydroxy esters with good yields and high enantioselectivities.
authors.affiliation: Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan 30013, Republic of China.
authors.forename: Hsyueh-Liang
authors.initials: HL
authors.lastname: Wu
authors.forename: Ping-Yu
authors.initials: PY
authors.lastname: Wu
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Shen
authors.forename: Biing-Jiun
authors.initials: BJ
authors.lastname: Uang
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D001892:Camphanes / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D009025:Morpholines / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D000447:Aldehydes; D001892:Camphanes; D004952:Esters; D007659:Ketones; D008024:Ligands; D009025:Morpholines; D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; C511262:dimethylzinc