title: Intraocular pressure, central corneal thickness, and prevalence of open-angle glaucoma: the Los Angeles Latino Eye Study.
abstract: OBJECTIVE
  To examine the relationship between the prevalence of open-angle glaucoma (OAG) and intraocular pressure (IOP) and the impact of central corneal thickness (CCT) on this relationship.
  
  
  METHODS
  Population-based cross-sectional study.
  
  
  METHODS
  The study cohort consisted of 5,970 participants from the Los Angeles Latino Eye Study (LALES) with no history of glaucoma treatment and with complete ophthalmic examination data. The relationship between the prevalence of OAG and IOP was contrasted across persons with CCT designated as thin, normal, or thick.
  
  
  RESULTS
  Prevalence of OAG was exponentially related to IOP. When stratified by CCT, persons with thin CCT had a significantly higher prevalence of OAG than did those with normal or thick CCTs at all levels of IOP. Adjusting each IOP individually for CCT did not impact significantly the relationship between the prevalence of OAG and IOP.
  
  
  CONCLUSIONS
  These findings suggest that adjusting for the impact of CCT on IOP by correction algorithms is not necessary in a population based assessment of glaucoma prevalence; CCT, however, is an important independent risk factor for the prevalence of OAG.
authors.affiliation: Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Francis
authors.forename: Rohit
authors.initials: R
authors.lastname: Varma
authors.forename: Vikas
authors.initials: V
authors.lastname: Chopra
authors.forename: Mei-Ying
authors.initials: MY
authors.lastname: Lai
authors.forename: Corina
authors.initials: C
authors.lastname: Shtir
authors.forename: Stanley P
authors.initials: SP
authors.lastname: Azen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D015331:Cohort Studies; D003315:Cornea / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000453:epidemiology* / Q000208:ethnology; D006630:Hispanic or Latino; D006801:Humans; D007429:Intraocular Pressure; D015141:Los Angeles / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors