The Groningen Longitudinal Glaucoma Study. II. A prospective comparison of frequency doubling perimetry, the GDx nerve fibre analyser and standard automated perimetry in glaucoma suspect patients.
OBJECTIVE
We aimed to determine prospectively the incidence of abnormal test results on frequency doubling perimetry (FDT), the nerve fibre analyser (GDx) and standard automated perimetry (SAP) in a cohort of glaucoma suspect patients with normal findings for all these tests at baseline.


METHODS
Seventy glaucoma suspect patients were followed prospectively for 4 years with SAP (Humphrey field analyser 30-2 SITA Fast), FDT (C-20 full-threshold) and GDx (Version 2.010) in a clinical setting. All patients had normal baseline test results on SAP, FDT and GDx. After the follow-up period, the number of patients who converted (whose test results changed from normal at baseline to reproducibly abnormal during follow-up) were counted for each technique and then compared. The cut-off point for FDT was > 1 depressed test-point p < 0.01 in the total deviation probability plot; the cut-off point for GDx was the Number > 29.


RESULTS
Of the 70 glaucoma suspect patients, three converted on FDT, 14 on GDx and six on SAP. These proportions are significantly different for GDx versus SAP (p = 0.033) and GDx versus FDT (p = 0.002), but not for FDT versus SAP (p = 0.256).


CONCLUSIONS
The most frequent finding after a 4-year follow-up was conversion on GDx.
Jansonius
Nomdo M
NM
Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. n.m.jansonius@ohk.umcg.nl
Heeg
Govert P
GP
D000368:Aged; D001331:Automation; D015331:Cohort Studies; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000175:diagnosis*; D011446:Prospective Studies; D058609:Visual Field Tests / Q000379:methods*