Cyanopeptoline CB071: a cyclic depsipeptide isolated from the freshwater cyanobacterium Aphanocapsa sp.
Cyanopeptolin CB071 (1), a trypsin inhibitor, was isolated from the freshwater cyanobacterium Aphanocapsa sp. Its complete structure was determined by detailed NMR spectroscopy and MS analyses, along with chemical reactions. The compound showed inhibition of trypsin at a concentration of IC50=2.5 microM.
Choi
Hyukjae
H
Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, Seoul, Korea.
Oh
Sun Kwan
SK
Yih
Wonho
W
Chin
Jungwook
J
Kang
Heonjoong
H
Rho
Jung-Rae
JR
D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005618:Fresh Water / Q000382:microbiology; D015394:Molecular Structure; D014361:Trypsin Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D047630:Depsipeptides; D014361:Trypsin Inhibitors; C531494:cyanopeptolin CB071