[Does rocuronium displace the position of suxamethonium?].
A full stomach patient often requires a rapid sequence induction (RSI) technique to protect against gastric aspiration. Suxamethonium is the most common muscle relaxant used because it has a fast onset and a short duration. Unfortunately it can have serious side effects as a result of its membrane depolarizing effect and release of potassium. Rocuronium has been suggested to create intubating conditions similar to suxamethonium. However, it has been proved that suxamethonium creates superior intubation conditions to rocuronium in a large meta-analysis comparing intubation conditions. Once Org 25969 (sugammadex) is available to rapidly bind rocuronium and reverse its action, rocuronium may replace succinylcholine for rapid-sequence induction.
Sasakawa
Tomoki
T
Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, Asahikawa 078-8510.
Iwasaki
Hiroshi
H
D000556:Ambulatory Surgical Procedures; D000732:Androstanols / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006801:Humans; D007442:Intubation, Intratracheal; D009467:Neuromuscular Depolarizing Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000077123:Rocuronium; D013390:Succinylcholine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000008:administration & dosage / Q000494:pharmacology
D000732:Androstanols; D009467:Neuromuscular Depolarizing Agents; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D013390:Succinylcholine; D000077123:Rocuronium