title: Granular corneal dystrophy in 830-nm spectral optical coherence tomography.
abstract: OBJECTIVE
  Spectral optical coherence tomography (SOCT) is a new imaging technique that can provide high-resolution tomograms much faster and with higher sensitivity than conventional Time domain (TdOCT) systems. Its usefulness in producing cross-sectional imaging of different corneal pathologies in vivo has already been presented. The aim of this case report is to show 830-nm SOCT findings in granular corneal dystrophy.
  
  
  METHODS
  A 48-year-old woman with granular corneal dystrophy was examined with a slit-lamp, confocal microscope (Confoscan 4) and a prototype SOCT instrument constructed at the Institute of Physics, Nicolaus Copernicus University, Torun, Poland. A genetic examination showed a mutation of arginine 555-to-tryptophan (Arg555Trp) in the TGFBI gene that confirmed the clinical diagnosis.
  
  
  RESULTS
  SOCT tomograms showed multiple hyperreflective changes throughout the corneal stroma that corresponded to hyaline deposits. Precise and objective assessment of the localization, size, shape, and light scattering properties of the pathologic changes was possible. Three-dimensional rendering of the acquired data allowed a comprehensive evaluation of the deposits in the central cornea.
  
  
  CONCLUSIONS
  SOCT (830 nm) provides clinically valuable 2- and 3-dimensional assessments of pathomorphologic changes in granular corneal dystrophy in vivo.
authors.affiliation: Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland. bartka@by.onet.pl
authors.forename: Bartlomiej J
authors.initials: BJ
authors.lastname: Kaluzny
authors.forename: Anna
authors.initials: A
authors.lastname: Szkulmowska
authors.forename: Maciej
authors.initials: M
authors.lastname: Szkulmowski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Bajraszewski
authors.forename: Anna
authors.initials: A
authors.lastname: Wawrocka
authors.forename: Maciej R
authors.initials: MR
authors.lastname: Krawczynski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kowalczyk
authors.forename: Maciej
authors.initials: M
authors.lastname: Wojtkowski
mesh_terms: D003317:Corneal Dystrophies, Hereditary / Q000175:diagnosis* / Q000235:genetics; D003319:Corneal Stroma / Q000473:pathology*; D016326:Extracellular Matrix Proteins / Q000235:genetics; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D018613:Microscopy, Confocal; D008875:Middle Aged; D017354:Point Mutation; D041623:Tomography, Optical Coherence; D016212:Transforming Growth Factor beta / Q000235:genetics; D000099222:betaIG-H3 Protein
chemical_list: D016326:Extracellular Matrix Proteins; D016212:Transforming Growth Factor beta; D000099222:betaIG-H3 Protein