Determinants and impact of sleep duration in children and adolescents: data of the Kiel Obesity Prevention Study.
OBJECTIVE
This study investigates determinants of sleep duration and its impact on nutritional status, resting energy expenditure (REE), cardiometabolic risk factors and hormones in children/adolescents.


METHODS
In 207 girls and 207 boys (13.0+/-3.4 (6.1-19.9) years) body mass index standard deviation score (BMI SDS), waist circumference (WC) z-score, body composition (air-displacement plethysmography), REE (ventilated hood system; n=312) and cardiometabolic risk factors/hormones (n=250) were assessed. Greater than 90th percentile of BMI/WC references was defined as overweight/overwaist. Sleep duration, media consumption (TV watching/computer use), physical activity, dietary habits, parental BMI, socio-economic status and early infancy were assessed by questionnaire. Short sleep was defined as <10 h per day for children <10 years and otherwise <9 h per day.


RESULTS
Total 15.9% participants were overweight, mean sleep duration was 8.9+/-1.3 h per day. Age explained most variance in sleep (girls: 57.0%; boys: 41.2%) besides a high nutrition quality score (girls: 0.9%) and a low media consumption (boys: 1.3%). Sleep was inversely associated with BMI SDS/WC z-score (girls: r=-0.17/-0.19, P<0.05; boys: r=-0.21/-0.20, P<0.01), which was strengthened after adjusting for confounders. Short vs long sleep was associated with 5.5-/2.3-fold higher risks for obesity/overwaist (girls). After adjusting for age, REE (adjusted for fat-free mass) was positively associated with sleep in boys (r=0.16, P<0.05). Independently of age and WC z-score, short sleep was associated with lower adiponectin levels in boys (11.7 vs 14.4 microg/ml, P<0.05); leptin levels were inversely related to sleep in girls (r=-0.23, P<0.05). Homoeostasis model assessment-insulin resistance (r=-0.20, P<0.05) and insulin levels (r=-0.20, P<0.05) were associated with sleep (girls), which depended on WC z-score.


CONCLUSIONS
Age mostly determined sleep. Short sleep was related to a higher BMI SDS/WC z-score (girls/boys), a lower REE (boys), higher leptin (girls) and lower adiponectin levels (boys).
Hitze
B
B
Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts Universität Kiel, Kiel, Germany.
Bosy-Westphal
A
A
Bielfeldt
F
F
Settler
U
U
Plachta-Danielzik
S
S
Pfeuffer
M
M
Schrezenmeir
J
J
Mönig
H
H
Müller
M J
MJ
D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000367:Age Factors; D015992:Body Mass Index; D001837:Body Weights and Measures; D002648:Child; D003201:Computers; D004032:Diet / Q000592:standards; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D015994:Incidence; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D009752:Nutritional Status; D009765:Obesity / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D012737:Sex Factors; D012890:Sleep / Q000502:physiology*; D013690:Television; D013997:Time Factors; D055105:Waist Circumference; D055815:Young Adult
D052242:Adiponectin; D007328:Insulin; D020738:Leptin