title: Role of osteopontin in calcification in autoimmune pancreatitis.
abstract: OBJECTIVE
  The aim of the present study was to determine the potential for pancreatic calcification in autoimmune pancreatitis by investigating osteopontin and CD44 expression.
  
  
  METHODS
  Human pancreatic tissues in normal pancreas, chronic pancreatitis, and autoimmune pancreatitis were obtained from the surgical specimens of 42 patients. Pancreatic tissues from male Wistar Bonn/Kobori rats were also used as an animal autoimmune pancreatitis model.
  
  
  RESULTS
  The incidences of osteopontin expression in centroacinar cells in chronic pancreatitis with calcification and in autoimmune pancreatitis were significantly greater than that in normal pancreas (P < 0.05). Some cases of chronic pancreatitis and autoimmune pancreatitis expressed CD44 in centroacinar cells and ductal cells. In male Wistar Bonn/Kobori rats, the inflammatory area and percentage of osteopontin-CD44-positive cells increased with advancing age (P < 0.01 or 0.05).
  
  
  CONCLUSIONS
  These results suggest that autoimmune pancreatitis has the potential for pancreatic calcification over a long-term clinical course.
authors.affiliation: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takada
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nakazawa
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Ohara
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ando
authors.forename: Kazuki
authors.initials: K
authors.lastname: Hayashi
authors.forename: Itaru
authors.initials: I
authors.lastname: Naito
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Okumura
authors.forename: Hajime
authors.initials: H
authors.lastname: Tanaka
authors.forename: Tamaki
authors.initials: T
authors.lastname: Yamada
authors.forename: Satoru
authors.initials: S
authors.lastname: Takahashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Joh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001327:Autoimmune Diseases / Q000378:metabolism; D002114:Calcinosis / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism*; D050500:Pancreatitis, Chronic / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D055815:Young Adult
chemical_list: D018960:Hyaluronan Receptors; D053495:Osteopontin