title: Can tumor growth be further inhibited by combining drugs such as bortezomib with image-guided interventional oncologic procedures?
abstract: Poff et al (1) were able to demonstrate delayed tumor growth of murine squamous cell carcinoma in an orthotopic C3H murine tumor model when adding pulsed high-intensity focused ultrasound (HIFU) as an adjunctive pretreatment to bortezomib, a proteasome inhibitor. In essence, this combination therapy induced greater apoptosis than did the drug alone and enabled the achievement of equivalent efficacy with a substantial dose reduction of a potentially toxic drug.
authors.affiliation: Department of Radiology, Beth Israel Deaconess Medical Center, 1 Deaconess Rd, Room CC308, Boston, MA 02215, USA. sgoldber@bidmc.harvard.edu
authors.forename: S Nahum
authors.initials: SN
authors.lastname: Goldberg
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D001897:Boronic Acids / Q000494:pharmacology*; D000069286:Bortezomib; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000628:therapy*; D003131:Combined Modality Therapy; D051379:Mice; D011719:Pyrazines / Q000494:pharmacology*; D014464:Ultrasonic Therapy
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib