title: Microbleeds in moyamoya disease: susceptibility-weighted imaging versus T2*-weighted imaging at 3 Tesla.
abstract: OBJECTIVE
  To prospectively evaluate differences in detectability of cerebral microbleeds (MBs) in Moyamoya disease (MMD) on susceptibility-weighted imaging (SWI) and T2*-weighted imaging (T2*WI) at 3 T.
  
  
  METHODS
  SWI and T2*WI were applied for 50 consecutive MMD patients. MB was defined as a very low signal intensity area in each sequence without continuity from surrounding vessel structures. Numbers of MBs were compared between the 2 sequences. To assess visualization, a grading score was assigned to each MB from Grade 3 (prominent) to Grade 0 (normal-appearing) on SWI and T2*WI, respectively, and were compared by Wilcoxon signed rank test.
  
  
  RESULTS
  A total of 37 MBs were detected in 21 patients (42%) on SWI, compared with 27 MBs in 16 patients (32%) on T2*WI, with significant difference in number of MBs between the 2 sequences (P = 0.002). Lesions displayed greater visual grading score on SWI than on T2*WI (P < 0.0001).
  
  
  CONCLUSIONS
  SWI offers better detectability of MBs in MMD than T2*WI at 3 T.
authors.affiliation: Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Mori
authors.forename: Yukio
authors.initials: Y
authors.lastname: Miki
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Kikuta
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Fushimi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Okada
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Urayama
authors.forename: Nobukatsu
authors.initials: N
authors.lastname: Sawamoto
authors.forename: Hidenao
authors.initials: H
authors.lastname: Fukuyama
authors.forename: Nobuo
authors.initials: N
authors.lastname: Hashimoto
authors.forename: Kaori
authors.initials: K
authors.lastname: Togashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002543:Cerebral Hemorrhage / Q000175:diagnosis*; D002648:Child; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009072:Moyamoya Disease / Q000150:complications*; D011446:Prospective Studies