Targeting the most upstream site of Wnt signaling pathway provides a strategic advantage for therapy in colorectal cancer.
The Wnt signaling pathway has important functions in development, tissue homeostasis, and regeneration. Deregulation of canonical Wnt/beta-catenin signaling is frequently found in various human cancers, particularly in colorectal cancer, and non-canonical Wnt signaling pathways also have been implicated in neoplasia. Colorectal cancer is a multi-pathway disease. Activation of Wnt signaling by both genetic and epigenetic alterations has been found to be important for both, initiation and progression of colorectal cancer. In addition, since Wnt signaling results in diverse downstream intracellular events, targeted inhibition of Wnt/beta-catenin signaling at the most upstream site of this pathway is a rational and an advantageous new approach for the therapy of colorectal cancer.
Qi
Jian
J
Department of Gastroenterology of Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei Province, China.
Zhu
You-Qing
YQ
D000818:Animals; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D016503:Drug Delivery Systems; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism
D051153:Wnt Proteins; D051176:beta Catenin