Turning down tau phosphorylation.
Phosphorylation and glycosylation of the tau protein, which is implicated in neurodegenerative diseases, are intimately linked. In vivo pharmacological inhibition of tau deglycosylation may be a new way to suppress abnormal tau phosphorylation, known to be involved in the formation of neurofibrillary tangles in the brain.
Fischer
Peter M
PM
School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham NG7 2RD, UK. peter.fischer@nottingham.ac.uk
D015195:Drug Design; D006801:Humans; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D016874:Neurofibrillary Tangles / Q000187:drug effects*; D010766:Phosphorylation; D024801:Tauopathies / Q000188:drug therapy*; D001619:beta-N-Acetylhexosaminidases / Q000037:antagonists & inhibitors*; D016875:tau Proteins / Q000378:metabolism*
D016875:tau Proteins; C110628:hexosaminidase C; D001619:beta-N-Acetylhexosaminidases