title: In vitro BACE-1 inhibitory phenolic components from the seeds of Psoralea corylifolia.
abstract: A new isoflavone, neocorylin ( 1) was isolated from the seeds extract of Psoralea corylifolia L. (Fabaceae), together with eight known constituents ( 2 - 9), i. e., bakuchiol ( 2), psoralen ( 3), bavachromene ( 4), isobavachromene ( 5), bavachalcone ( 6), isobavachalcone ( 7), 7,8-dihydro-8-(4-hydrophenyl)-2,2-dimethyl-2 H,6 H-[1,2- B:5,4- B']dipyran-6-one ( 8), and bavachinin ( 9). The structure of the new isoflavone 1 was elucidated as 7-hydroxy-3-[2-methyl-2-(4-methylpenten-3-yl)-2 H-chromen-6-yl]-4 H-chromen-4-one by spectroscopic analyses. Neocorylin ( 1) as well as related compounds 2, 4 - 6, 8 and 9 exhibited a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
authors.affiliation: Korea Research Institute of Chemical Technology, Daejeon, Korea.
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Choi
authors.forename: Gyu Hwan
authors.initials: GH
authors.lastname: Yon
authors.forename: Kyung Sik
authors.initials: KS
authors.lastname: Hong
authors.forename: Dae Seok
authors.initials: DS
authors.lastname: Yoo
authors.forename: Chun Whan
authors.initials: CW
authors.lastname: Choi
authors.forename: Woo-Kyu
authors.initials: WK
authors.lastname: Park
authors.forename: Jae Yang
authors.initials: JY
authors.lastname: Kong
authors.forename: Young Sup
authors.initials: YS
authors.lastname: Kim
authors.forename: Shi Yong
authors.initials: SY
authors.lastname: Ryu
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors*; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D029907:Psoralea / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
chemical_list: D007529:Isoflavones; D010936:Plant Extracts; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human