[Effect of Jiangtang Xiaozhi capsule on morphological changes of islet and liver in rat model [corrected] of type 2 diabetes [corrected] mellitus].
OBJECTIVE
To explore the effect of Jiangtang Xiaozhi capsule (JXC) on morphological changes of islets and liver at rat model of type 2 diabetic mellitus and provide the experimental basis for the clinical therapy of type 2 diabetic mellitus.


METHODS
Wister rats were fed on a diet enriched in fat and glucose to induce insulin resistan, the rats were injected intrapertoneally with a low-dose streptozotocin (STZ) twice (25 mg x kg(-1)) to induce hyperglycemia, so the successful rat model of type 2 diabetes were established. The experimental rats were divided into model group, high dose JXC group, middle dose JXC group, low dose JXC group, Erjiashuanggua group, Jinqijiangtang group and normal control group. After all the treatment groups received their own medicine for two months, all the rats were sacrificed and morphological examination on their islets and livers were performed.


RESULTS
Fatty liver in various degrees was seen in the model group and all the treatment groups, but the liver steatosis in middle and low dose JXC groups was significantly milder than that in model group (P < 0.05). Islets in the high dose JXC group were significantly more than that in the model group (P < 0.05).


CONCLUSIONS
JXC can improve significantly the pathological change in islets and liver steatosis at rat model of type 2 diabetic mellitus.
Yan
Ai-Guo
AG
Xiyuan Hospital, China Academy of Chinese Medicinal Science, Beijing 100091, China.
Ge
Zheng-Yan
ZY
Liu
Jian-Xun
JX
Dong
Xiao-Xia
XX
Li
Hong-Kun
HK
Jin
Long
L
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000473:pathology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007515:Islets of Langerhans / Q000187:drug effects* / Q000473:pathology*; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D008853:Microscopy; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal