Urinary isoprostanes in Friedreich ataxia: lack of correlation with disease features.
To assess the utility of urinary isoprostanes as markers of oxidative injury in Friedreich ataxia (FA), we compared levels of urinary F(2)-isoprostanes in patients with FA and healthy control subjects. Levels of urinary F(2)-isoprostanes in FA patients were not different from controls and were not significantly associated with age, GAA repeat length, disability level, or the use of antioxidants. Thus, urinary F(2)-isoprostanes are not a useful biomarker in FA.
Myers
Lauren M
LM
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Lynch
David R
DR
Farmer
Jennifer M
JM
Friedman
Lisa S
LS
Lawson
John A
JA
Wilson
Robert B
RB
D000328:Adult; D005260:Female; D005621:Friedreich Ataxia / Q000652:urine*; D006801:Humans; D028421:Isoprostanes / Q000652:urine*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D028421:Isoprostanes