Virus-sized vaccine delivery systems.
In a return to the early days of vaccine development during which effective vaccines were produced against viruses, virus-sized vaccine delivery systems have made a comeback. Using modern production technologies these nanoparticles have proved to be very effective at inducing cellular and humoral immune responses. Here, we review a number of vaccine delivery systems based on nanoparticles in the size range of typical viruses. Different strategies for generating these particles, ranging from recombinant virus-like particles to inert nanobeads via ISCOMs and nanoparticle-based DNA vaccine delivery systems, are discussed. In addition, possible mechanisms of immune induction are explored.
Scheerlinck
Jean-Pierre Y
JP
Centre for Animal Biotechnology, Faculty of Veterinary Science, The University of Melbourne, Parkville, 3010 Vic., Australia. j.scheerlinck@unimelb.edu.au
Greenwood
Deanne L V
DL
D000818:Animals; D016503:Drug Delivery Systems; D055354:Exosomes; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D014612:Vaccines / Q000008:administration & dosage* / Q000737:chemistry*; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000737:chemistry; D014780:Viruses / Q000648:ultrastructure
D014612:Vaccines; D019444:Vaccines, DNA