A significant interaction between moxifloxacin and warfarin in a patient with a mitral bioprosthetic valve.
Moxifloxacin is an advanced-generation fluoroquinolone with a broad spectrum of antimicrobial activity that is not metabolized by cytochrome P450 system. Therefore, the drug interaction of moxifloxacin is rarely seen. It has been reported that moxifloxacin is safe and well tolerable. We aimed to report a drug interaction between moxifloxacin and warfarin in a 74-year-old patient with a prosthetic mitral valve.
Yildiz
Fatih
F
Department of Internal Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey. drcayli@yahoo.com
Kurtaran
Behice
B
Cayli
Murat
M
Candevir
Aslihan
A
Sümbül
Zehra
Z
D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects*; D000925:Anticoagulants / Q000009:adverse effects*; D001372:Aza Compounds / Q000009:adverse effects*; D001705:Bioprosthesis; D001777:Blood Coagulation / Q000187:drug effects; D016913:Blood Component Transfusion; D004347:Drug Interactions; D004696:Endocarditis / Q000382:microbiology / Q000628:therapy; D024841:Fluoroquinolones; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation*; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008943:Mitral Valve / Q000382:microbiology / Q000601:surgery*; D000077266:Moxifloxacin; D011804:Quinolines / Q000009:adverse effects*; D014859:Warfarin / Q000009:adverse effects*
D000890:Anti-Infective Agents; D000925:Anticoagulants; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D014859:Warfarin; D000077266:Moxifloxacin