Insulinomimetic Zn(II) complexes as evaluated by both glucose-uptake activity and inhibition of free fatty acids release in isolated rat adipocytes.
We prepared 4 new Zn(II) complexes with Zn(O4), Zn(N(2)O(2)), and Zn(S2O2) coordination modes and evaluated their insulinomimetic activities in an in vitro study. The insulinomimetic activities of bis(pyrrole-2-carboxylato)zinc (Zn(pc)2), bis(alpha-furonic acidato)zinc (Zn(fa)2), bis(thiophene-2-carboxylato)zinc (Zn(tc)2), and bis(thiophene-2-acetato)zinc (Zn(ta)2) complexes were found to be higher than that of zinc sulfate (ZnSO4). Zn(ta)2 showed the highest insulinomimetic activity among the Zn(II) complexes because of its high lipophilicity.
Nishide
Midori
M
Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University, Kobe, Japan.
Yoshikawa
Yutaka
Y
Yoshikawa
Eriko U
EU
Matsumoto
Kinuyo
K
Sakurai
Hiromu
H
Kajiwara
Naemi M
NM
D017667:Adipocytes / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000737:chemistry; D051381:Rats; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology*
D005230:Fatty Acids, Nonesterified; D007004:Hypoglycemic Agents; D007328:Insulin; D005947:Glucose; D015032:Zinc