Anti-inflammatory effects of leaf and twig of Tripterygium wilfordii on paw edema in mice.
The root of Tripterygium wilfordii (TWH) is a traditional Chinese herb used to treat the immune-related diseases such as rheumatoid arthritis, whereas the leaf and twig of TWH was considered useless and discarded. We performed a study on the anti-inflammatory effects on the leaf and twig portion agent using carrageenan- and adjuvant-induced paw edema in rats. They showed a marked inhibitory effect on edema in both models of inflammation in rats, at the dose of 50, 100 and 200 mg/kg, especially on secondary immunological arthritis. Based on this study, we confirmed that the leaf and twig of TWH is a potentially useful drug suitable for further evaluation for rheumatoid arthritis and can replace root of TWH.
Yu
Longjiang
L
School of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, PR China. yulongjiang@hust.edu.cn
Ao
Mingzhang
M
Wan
Junmei
J
Zhang
Yongzhong
Y
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D002351:Carrageenan; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005534:Foot Diseases / Q000139:chemically induced / Q000188:drug therapy; D005620:Freund's Adjuvant; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves; D018547:Plant Stems; D051381:Rats; D017208:Rats, Wistar; D029757:Tripterygium
D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D002351:Carrageenan; D005620:Freund's Adjuvant