title: [An analysis of the causes, characteristics, and consequences of reexposure to a drug or compound responsible for a hepatotoxicity event].
abstract: BACKGROUND
  reexposure to a causal agent represents a potentially serious event in hepatotoxicity.
  
  
  OBJECTIVE
  to assess the characteristics and outcome of cases with positive reexposure.
  
  
  METHODS
  a retrospective study of cases with evidence of positive reexposure included in Registro Español de Hepatopatías Asociadas a Medicamentos, and an analysis of their relation to demographic and clinical variables, causality, course, and consequences.
  
  
  RESULTS
  of a total of 520 cases 31 (6%) met reexposure criteria. Fatal outcomes, needs for admission, and mean recovery time were all higher for hepatocellular-type toxic injury. The most commonly identified drug class was antibiotics. On most occasions (73%) reexposure to the causal compound escaped notice because of: absence of index case diagnosis, lack of information to patients and their physicians, and (12%) development of cross reactions between structurally similar drugs.
  
  
  CONCLUSIONS
  accidental reexposure to a drug or a structurally-related compound after an initial hepatotoxicity event is common and may have serious consequences, particularly in hepatocellular-type toxicity. Careful history taking and reflecting diagnostic suspicion in the initial episode s record may reduce the incidence of this iatrogenic event.
authors.affiliation: Servicio de Aparato Digestivo, Hospital Universitario Virgen de La Victoria, Facultad de Medicina, Málaga.
authors.forename: A
authors.initials: A
authors.lastname: Fernández-Castañer
authors.forename: M
authors.initials: M
authors.lastname: García-Cortés
authors.forename: M I
authors.initials: MI
authors.lastname: Lucena
authors.forename: Y
authors.initials: Y
authors.lastname: Borraz
authors.forename: G
authors.initials: G
authors.lastname: Peláez
authors.forename: J
authors.initials: J
authors.lastname: Costa
authors.forename: S
authors.initials: S
authors.lastname: Anzola
authors.forename: J
authors.initials: J
authors.lastname: Salmerón
authors.forename: S
authors.initials: S
authors.lastname: Avila
authors.forename: J A
authors.initials: JA
authors.lastname: Durán
authors.forename: A
authors.initials: A
authors.lastname: Malcón de Dios
authors.forename: M
authors.initials: M
authors.lastname: Romero-Gómez
authors.forename: A
authors.initials: A
authors.lastname: Madrazo
authors.forename: T
authors.initials: T
authors.lastname: Muñoz-Yagüe
authors.forename: R J
authors.initials: RJ
authors.lastname: Andrade
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology* / Q000209:etiology*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies