Granular corneal dystrophy in 830-nm spectral optical coherence tomography.
OBJECTIVE
Spectral optical coherence tomography (SOCT) is a new imaging technique that can provide high-resolution tomograms much faster and with higher sensitivity than conventional Time domain (TdOCT) systems. Its usefulness in producing cross-sectional imaging of different corneal pathologies in vivo has already been presented. The aim of this case report is to show 830-nm SOCT findings in granular corneal dystrophy.


METHODS
A 48-year-old woman with granular corneal dystrophy was examined with a slit-lamp, confocal microscope (Confoscan 4) and a prototype SOCT instrument constructed at the Institute of Physics, Nicolaus Copernicus University, Torun, Poland. A genetic examination showed a mutation of arginine 555-to-tryptophan (Arg555Trp) in the TGFBI gene that confirmed the clinical diagnosis.


RESULTS
SOCT tomograms showed multiple hyperreflective changes throughout the corneal stroma that corresponded to hyaline deposits. Precise and objective assessment of the localization, size, shape, and light scattering properties of the pathologic changes was possible. Three-dimensional rendering of the acquired data allowed a comprehensive evaluation of the deposits in the central cornea.


CONCLUSIONS
SOCT (830 nm) provides clinically valuable 2- and 3-dimensional assessments of pathomorphologic changes in granular corneal dystrophy in vivo.
Kaluzny
Bartlomiej J
BJ
Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland. bartka@by.onet.pl
Szkulmowska
Anna
A
Szkulmowski
Maciej
M
Bajraszewski
Tomasz
T
Wawrocka
Anna
A
Krawczynski
Maciej R
MR
Kowalczyk
Andrzej
A
Wojtkowski
Maciej
M
D003317:Corneal Dystrophies, Hereditary / Q000175:diagnosis* / Q000235:genetics; D003319:Corneal Stroma / Q000473:pathology*; D016326:Extracellular Matrix Proteins / Q000235:genetics; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D018613:Microscopy, Confocal; D008875:Middle Aged; D017354:Point Mutation; D041623:Tomography, Optical Coherence; D016212:Transforming Growth Factor beta / Q000235:genetics; D000099222:betaIG-H3 Protein
D016326:Extracellular Matrix Proteins; D016212:Transforming Growth Factor beta; D000099222:betaIG-H3 Protein