Establishment and characterization of a human cell line derived from a uterine papillary serous carcinoma with wild-type p53 function.
Uterine papillary serous carcinoma is an uncommon histologic subtype of endometrial cancer that behaves aggressively and has a poor prognosis. We successfully established a uterine papillary serous carcinoma cell line. The population-doubling time was approximately 16 h. Although loss of p53 function is considered critical for the molecular pathogenesis of uterine papillary serous carcinoma, p53 was not only mutated but functionally active in this cell line. This newly established cell line should be useful for investigating the characteristics of uterine papillary serous carcinoma.
Hashimoto
Hisashi
H
Department of Translational Research, Ehime University School of Medicine, Toon, Japan.
Kojima
Atsumi
A
Sudo
Tamotsu
T
Ohki
Noriyoshi
N
Yamaguchi
Satoshi
S
Mikami
Yoshiki
Y
Ito
Masaharu
M
Nishimura
Ryuichiro
R
D000368:Aged; D000818:Animals; D002455:Cell Division; D045744:Cell Line, Tumor; D018283:Cystadenocarcinoma, Papillary / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D007621:Karyotyping; D051379:Mice; D008819:Mice, Nude; D009154:Mutation; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000502:physiology*; D014594:Uterine Neoplasms / Q000235:genetics / Q000473:pathology
D016159:Tumor Suppressor Protein p53