[Remifentanil and conventional laryngoscopy and tracheal intubation].
BACKGROUND
Laryngoscopy and tracheal intubation in patients undergoing surgical procedures under balanced general endotracheal anesthesia may provoke a sympathetic response with tachycardia and hypertension.


METHODS
Various pharmacological agents, such as anesthetics, analgesics, adrenergic blockers, can modify the hemodynamic response. This investigation evaluated the effects of three different doses of remifentanil on the cardiovascular response to laryngoscopy and orotracheal intubation. The study included 100 patients of both sexes, aged between 21 and 64 years, undergoing various types of surgical procedures under general anesthesia. Patients received remifentanil just before the initiation of anesthesia, and thiopental was used for induction of anesthesia.


CONCLUSIONS
The results of this investigation indicate that intravenous bolus dose of remifentanil of 0.5 microg/kg, combined with thiopental, reduces the cardiovascular response to laryngoscopy and tracheal intubation, whereas bolus doses of remifentanil, 1 and 1.5 microg/kg, provide cardiovascular stability, as well as safe and efficient induction of anesthesia.
Vicković
Sanja
S
Klinika za anesteziju i intenzivnu terapiju, Klinicki centar Vojvodine, Novi Sad. svickovic@neobee.net
Pjević
Miroslava
M
Stanisavljević
Snezana
S
D000328:Adult; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage* / Q000494:pharmacology; D000077208:Remifentanil
D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil