title: Can stereotactic fractionated radiation therapy become the standard of care for early stage non-small cell lung carcinoma.
abstract: Management of early stages non-small cell lung carcinoma has traditionally been surgery with radiation selected for medically inoperable patients. Recent emergence of stereotactic body radiation therapy allows for delivery of high radiation dose to the tumor while sparing normal lungs. This reviews compares loco-regional control, survival and complications rates between these two treatment modalities. Literature search identifies studies with stereotactic body radiation therapy and surgery for early stages non-small cell lung cancer. Effectiveness and toxicity of these two modalities was assessed. Stereotactic body radiation therapy is associated with minimal morbidity and provides comparable local control and survival in patients with multiple co-morbidities factors. Stereotactic body radiation therapy may become standard of care for operable early stages non-small cell lung cancer.
authors.affiliation: Department of Radiation Oncology, University of Arizona, 1501 N. Campbell Avenue, Tucson, AZ, USA. NamPhong.Nguyen@yahoo.com
authors.forename: Nam P
authors.initials: NP
authors.lastname: Nguyen
authors.forename: Linda
authors.initials: L
authors.lastname: Garland
authors.forename: James
authors.initials: J
authors.lastname: Welsh
authors.forename: Russ
authors.initials: R
authors.lastname: Hamilton
authors.forename: Deirdre
authors.initials: D
authors.lastname: Cohen
authors.forename: Vincent
authors.initials: V
authors.lastname: Vinh-Hung
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011013:Pneumonectomy / Q000379:methods; D011379:Prognosis; D011832:Radiation Injuries / Q000453:epidemiology / Q000517:prevention & control; D017564:Radiation Pneumonitis / Q000453:epidemiology / Q000517:prevention & control; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods / Q000592:standards*; D016032:Randomized Controlled Trials as Topic; D012015:Reference Standards; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D020775:Thoracic Surgery, Video-Assisted / Q000379:methods*; D016896:Treatment Outcome