[Anthracycline antibiotics and their derivatives--inhibitors of topoisomerase I].
The relationship between the structure of new semisynthetic derivatives of doxorubicin, daunorubicin, and carminomycin and their ability to inhibit topoisomerase 1 were studied. The new derivatives inhibit the activity of topoisomerase 1 at low concentrations, induce the death of K-562 leukemia cells in culture, and produce an antitumor effect in experimental animals with P388 leukemia.
Dezhenkova
L G
LG
Teviashova
A N
AN
Olsuf'eva
E N
EN
Treshchalin
I D
ID
Shtil'
A A
AA
Preobrazhenskaia
M N
MN
D000818:Animals; D002360:Carubicin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020014:K562 Cells; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors
D059004:Topoisomerase I Inhibitors; D004317:Doxorubicin; D002360:Carubicin; D003630:Daunorubicin