title: Possible association of Helicobacter pylori infection with laryngeal cancer risk: an evidence-based meta-analysis.
abstract: BACKGROUND
  Infection with Helicobacter pylori (H. pylori) is a major cause of various gastric diseases and has been reported to play a role in the process of tumorigenesis and progression of gastric carcinoma. However, whether H. pylori infection increases susceptibilities to other cancers is not fully understood. Several studies have been devoted to the relationship between H. pylori infection and laryngeal cancer risk and have yielded conflicting results. In this study, we aimed to evaluate the possible association of H. pylori infection with laryngeal cancer risk.
  
  
  METHODS
  The associated literature was acquired through deliberate searching and selected based on the established inclusion criteria for publications. Extracted data were further analyzed by a systematic meta-analysis.
  
  
  RESULTS
  A total of 15 papers were identified. Of these, five case-control studies were selected. Laryngeal cancer risk for H. pylori infection was 2.03-fold (95% CI=1.28-3.23) (Z=3.00, p<0.01) compared with the controls.
  
  
  CONCLUSIONS
  The pooled data suggest infection with H. pylori as a possible risk factor for laryngeal cancer.
authors.affiliation: Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Xian-Lu
authors.initials: XL
authors.lastname: Zhuo
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Wen-Lei
authors.initials: WL
authors.lastname: Zhuo
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Zhang
mesh_terms: D019317:Evidence-Based Medicine; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000150:complications*; D012307:Risk Factors