title: [Biological and neural bases of partner preferences in rodents: models to understand human pair bonds].
abstract: OBJECTIVE
  To analyse the biological and neural bases of partner preference formation in rodents as models to understand human pair bonding.
  
  
  METHODS
  Rodents are social individuals, capable of forming short- or long-lasting partner preferences that develop slowly by stimuli like cohabitation, or rapidly by stimuli like sex and stress. Dopamine, corticosteroids, oxytocin, vasopressin, and opioids form the neurochemical substrate for pair bonding in areas like the nucleus accumbens, the prefrontal cortex, the piriform cortex, the medial preoptic area, the ventral tegmental area and the medial amygdala, among others. Additional areas may participate depending on the nature of the conditioned stimuli by which and individual recognizes a preferred partner.
  
  
  CONCLUSIONS
  Animal models help us understand that the capacity of an individual to display long-lasting and selective preferences depends on neural bases, selected throughout evolution. The challenge in neuroscience is to use this knowledge to create new solutions for mental problems associated with the incapacity of an individual to display a social bond, keep one, or cope with the disruption of a consolidated one.
authors.affiliation: Instituto de Neuroetología. Universidad Veracruzana, Unidad Periférica Xalapa, Universidad Nacional Autónoma de México. gcoria@uv.mx
authors.forename: G A
authors.initials: GA
authors.lastname: Coria-Avila
authors.forename: M E
authors.initials: ME
authors.lastname: Hernández-Aguilar
authors.forename: R
authors.initials: R
authors.lastname: Toledo-Cárdenas
authors.forename: L I
authors.initials: LI
authors.lastname: García-Hernández
authors.forename: J
authors.initials: J
authors.lastname: Manzo
authors.forename: P
authors.initials: P
authors.lastname: Pacheco
authors.forename: M
authors.initials: M
authors.lastname: Miquel
authors.forename: J G
authors.initials: JG
authors.lastname: Pfaus
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D003075:Coitus; D005260:Female; D008297:Male; D023421:Models, Animal; D009769:Object Attachment; D012377:Rodentia; D013315:Stress, Psychological