Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma.
Five percent of 145 HIV-1 infected men enrolled in an assisted reproductive technology (ART) program harbored detectable HIV-1 RNA in semen, although they had no other sexually transmitted disease and their blood viral load was undetectable for at least 6 months under antiretroviral treatment. This result justifies measuring HIV-1 RNA in semen before the ART process and suggests that a residual risk of transmission has to be mentioned to the patients who would like to have unprotected sexual intercourse.
Marcelin
Anne-Geneviève
AG
UPMC Univ Paris 06, EA 2387, Paris, France. anne-genevieve.marcelin@psl.aphp.fr
Tubiana
Roland
R
Lambert-Niclot
Sidonie
S
Lefebvre
Gilles
G
Dominguez
Stéphanie
S
Bonmarchand
Manuela
M
Vauthier-Brouzes
Daniele
D
Marguet
Françoise
F
Mousset-Simeon
Nathalie
N
Peytavin
Gilles
G
Poirot
Catherine
C
D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000821:virology; D012367:RNA, Viral / Q000032:analysis* / Q000097:blood; D027724:Reproductive Techniques, Assisted; D012306:Risk; D012661:Semen / Q000821:virology*; D019562:Viral Load / Q000379:methods
D044966:Anti-Retroviral Agents; D012367:RNA, Viral