title: Changing diameters of cerebral vessels with age in human autopsy specimens: possible relationships to atherosclerotic changes.
abstract: OBJECTIVE
  It has been previously recognized that the anatomy of arterial bifurcations influences blood flow and has a significant role in the development of vascular disease.
  
  
  METHODS
  In the present study, we measured the average diameters of the internal carotid (ICA), anterior cerebral (ACA), and middle cerebral arteries (MCA) in autopsy cases. We also calculated the outflow to inflow area ratios for four distinct age groups and for each gender, using 33 adult autopsies and 7 fetuses.
  
  
  RESULTS
  The area ratios decreased with age in both male and female samples. The decrease in the male (30%, p<0.05) was greater than the decrease for the female (17%, p > 0.05). The average diameter of the ACA, MCA and ICA of both female and male cases increased up to the 25-44 age group, decreased for the 45-64 age group, with a second increase above the age of 65.
  
  
  CONCLUSIONS
  The decrease in the area ratios and the pattern of changes of the dimensions of the cerebral vessels with age are useful to examine the causal relationships of these pathologic conditions and raises novel questions about age and gender differences in the structure of the intracranial vessels.
authors.affiliation: Department of Anatomy, School of Medicine, Marmara University, Istanbul, Turkey. omerozdogmus@hotmail.com
authors.forename: O
authors.initials: O
authors.lastname: Ozdogmus
authors.forename: O
authors.initials: O
authors.lastname: Cakmak
authors.forename: A
authors.initials: A
authors.lastname: Yalin
authors.forename: D
authors.initials: D
authors.lastname: Keklik
authors.forename: Y
authors.initials: Y
authors.lastname: Uzün
authors.forename: S
authors.initials: S
authors.lastname: Cavdar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D020771:Anterior Cerebral Artery / Q000473:pathology / Q000503:physiopathology; D050197:Atherosclerosis / Q000473:pathology* / Q000503:physiopathology; D001344:Autopsy; D002343:Carotid Artery, Internal / Q000473:pathology / Q000503:physiopathology; D002536:Cerebral Arteries / Q000473:pathology* / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D005333:Fetus / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D012727:Sex Characteristics