[High-titer idiopathic acquired factor V inhibitor patient showing decreased activities of multiple coagulation factors].
A 72-year-old male presented with oral bleeding resulting from acquired factor V (FV) inhibitor. We observed abnormalities in prothrombin time (PT) (8%) and activated partial thromboplastin time (APTT) (>200 seconds). FV activity was less than 3%, and a mixing test did not correlate with PT. FV inhibitor assay demonstrated 240 Bethesda units/ml. The patient also showed markedly decreased activity of Factors II (13%) and X (14%). Oral bleeding disappeared and coagulation abnormalities improved with prednisolone therapy. High titer FV inhibitor might affect coagulation assays even in a patient with normal factor activity.
Shimizu
Ikuo
I
Department of Hematology, Nagano Red Cross Hospital.
Ichikawa
Naoaki
N
Yotsumoto
Mihoko
M
Sumi
Masahiko
M
Ueno
Mayumi
M
Kobayashi
Hikaru
H
D000368:Aged; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D005165:Factor V / Q000037:antagonists & inhibitors*; D006470:Hemorrhage / Q000097:blood* / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D009059:Mouth Diseases / Q000097:blood* / Q000188:drug therapy* / Q000209:etiology; D009061:Mouth Mucosa; D011239:Prednisolone / Q000008:administration & dosage; D016896:Treatment Outcome
D019774:Blood Coagulation Factor Inhibitors; D005165:Factor V; D011239:Prednisolone