CT appearance of Epstein-Barr virus-associated gastric carcinoma.
Epstein-Barr virus (EBV) is associated with pathogenesis of several epithelial neoplasms and lymphoproliferative disorders. A certain percentage of gastric carcinomas are associated with EBV. EBV-associated gastric carcinoma is a distinct entity associated with good prognosis. Multiple carcinomas are highly prevalent in EBV-associated gastric carcinomas, and this warrants thorough endoscopic investigation before determining the extent of surgical resection. Therefore, it is important to consider the presence of Epstein-Barr virus in the preoperative CT evaluation of gastric carcinomas. The purpose of this article is to illustrate the CT features of Epstein-Barr virus-associated gastric carcinoma. The surgically resected gastric carcinomas at our institution from 1998 to 2004 were reviewed and were examined for the presence of EBV, and 13 EBV-associated gastric carcinoma lesions were found in 10 patients. The preoperative CT scans were reviewed in these patients. Radiologic features that may suggest the presence of Epstein-Barr virus in gastric carcinoma includes location in the upper part of the stomach, a large thickness-to-width ratio, and a bulky portion projecting from the gastric wall.
Maeda
Eriko
E
Department of Radiology, University of Tokyo, Hongo, Bunkyo-ku, Japan. emaeda-tky@umin.ac.jp
Akahane
Masaaki
M
Uozaki
Hiroshi
H
Kato
Nobuyuki
N
Hayashi
Naoto
N
Fukayama
Masashi
M
Ohtomo
Kuni
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005260:Female; D005743:Gastrectomy; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery / Q000821:virology*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
D003287:Contrast Media; D009363:Neoplasm Proteins