The association between concomitant use of serotonergic antidepressants and lithium-induced polyuria. A multicenter medical chart review study.
BACKGROUND
A previous study aimed at revealing the prevalence and determinants of lithium induced polyuria suggested an increased risk of polyuria (urine volume > or =3 L/24 h) in those using serotonergic antidepressants next to lithium.


OBJECTIVE
The objective of our study was to re-evaluate this secondary finding in another study population.


METHODS
We performed a multicenter medical chart review study in patients using lithium in whom a 24-hour urine volume had been determined.


RESULTS
We included 116 patients, twelve (26%)of the 46 patients with polyuria used serotonergic antidepressants compared to ten (14%) of the 70 patients without polyuria. We found an increased risk of polyuria in lithium users concurrently using serotonergic antidepressants (oddsratio 2.86; 95% confidence interval 1.00-8.21), adjusted for age, gender, use of antiepileptics and thyreomimetics.


CONCLUSIONS
Our results confirm the previous secondary finding of an increased risk of polyuria in patients using serotonergic antidepressants next to lithium. Physicians should take this into account when evaluating polyuria in patients using lithium and when choosing an antidepressant in patients using lithium.
Wilting
I
I
Utrecht University, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology & Pharmacotherapy, Utrecht, The Netherlands.
Egberts
A C G
AC
Movig
K L L
KL
Laarhoven
J H M van
JH
Heerdink
E R
ER
Nolen
W A
WA
D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects*; D001244:Association; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D018021:Lithium Chloride / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011141:Polyuria / Q000139:chemically induced* / Q000453:epidemiology; D016896:Treatment Outcome
D000928:Antidepressive Agents; D018021:Lithium Chloride