title: Cheating on the edge.
abstract: We present the results of an individual agent-based model of antibiotic resistance in bacteria. Our model examines antibiotic resistance when two strategies exist: "producers"--who secrete a substance that breaks down antibiotics--and nonproducers ("cheats") who do not secrete, or carry the machinery associated with secretion. The model allows for populations of up to 10,000, in which bacteria are affected by their nearest neighbors, and we assume cheaters die when there are no producers in their neighborhood. Each of 10,000 slots on our grid (a torus) could be occupied by a producer or a nonproducer, or could (temporarily) be unoccupied. The most surprising and dramatic result we uncovered is that when producers and nonproducers coexist at equilibrium, nonproducers are almost always found on the edges of clusters of producers.
authors.affiliation: Department of Biology, University of Louisville, Louisville, Kentucky, United States of America. lee.dugatkin@louisville.edu
authors.forename: Lee Alan
authors.initials: LA
authors.lastname: Dugatkin
authors.forename: Aaron D
authors.initials: AD
authors.lastname: Dugatkin
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Atlas
authors.forename: Michael H
authors.initials: MH
authors.lastname: Perlin
mesh_terms: D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018407:Bacterial Physiological Phenomena; D003198:Computer Simulation; D024881:Drug Resistance, Bacterial; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D008957:Models, Genetic; D008962:Models, Theoretical; D012641:Selection, Genetic; D012984:Software; D013997:Time Factors; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases