Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk.
The alkyl-lysophospholipids edelfosine and miltefosine induce apoptosis in Leishmania infantum promastigotes. The finding that edelfosine-induced cell death can be regulated by the ectopic expression of the antiapoptotic and proapoptotic members of the Bcl-2 family of proteins Bcl-X(L) and Hrk suggests that this process is similar to apoptosis in eukaryotic cells.
Alzate
Juan Fernando
JF
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Arias
Andrés
A
Mollinedo
Faustino
F
Rico
Eva
E
de la Iglesia-Vicente
Janis
J
Jiménez-Ruiz
Antonio
A
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism; D018314:Leishmania infantum / Q000166:cytology / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D010742:Phospholipid Ethers / Q000494:pharmacology*; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000494:pharmacology; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D014162:Transfection; D051020:bcl-X Protein / Q000235:genetics / Q000378:metabolism
D000981:Antiprotozoal Agents; D051017:Apoptosis Regulatory Proteins; D010742:Phospholipid Ethers; D011994:Recombinant Proteins; D051020:bcl-X Protein; D010767:Phosphorylcholine; C026659:edelfosine; C039128:miltefosine