title: Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines.
abstract: The SAR and pharmacokinetic profiles of a series of multi-isoform PI3K inhibitors based on a 3,4-dihydro-2H-benzo[1,4]oxazine scaffold are disclosed.
authors.affiliation: UCB, Medicinal Chemistry, Granta Park, Great Abington, Cambridge CB21 6GS, UK. bengperry@yahoo.co.uk
authors.forename: Benjamin
authors.initials: B
authors.lastname: Perry
authors.forename: Rikki
authors.initials: R
authors.lastname: Alexander
authors.forename: Gavin
authors.initials: G
authors.lastname: Bennett
authors.forename: George
authors.initials: G
authors.lastname: Buckley
authors.forename: Tom
authors.initials: T
authors.lastname: Ceska
authors.forename: Tom
authors.initials: T
authors.lastname: Crabbe
authors.forename: Verity
authors.initials: V
authors.lastname: Dale
authors.forename: Lewis
authors.initials: L
authors.lastname: Gowers
authors.forename: Helen
authors.initials: H
authors.lastname: Horsley
authors.forename: Lynwen
authors.initials: L
authors.lastname: James
authors.forename: Kerry
authors.initials: K
authors.lastname: Jenkins
authors.forename: Karen
authors.initials: K
authors.lastname: Crépy
authors.forename: Claire
authors.initials: C
authors.lastname: Kulisa
authors.forename: Helen
authors.initials: H
authors.lastname: Lightfoot
authors.forename: Chris
authors.initials: C
authors.lastname: Lock
authors.forename: Stephen
authors.initials: S
authors.lastname: Mack
authors.forename: Trevor
authors.initials: T
authors.lastname: Morgan
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Nicolas
authors.forename: Will
authors.initials: W
authors.lastname: Pitt
authors.forename: Verity
authors.initials: V
authors.lastname: Sabin
authors.forename: Sara
authors.initials: S
authors.lastname: Wright
mesh_terms: D019540:Area Under Curve; D048588:Benzoxazines / Q000737:chemistry* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D018360:Crystallography, X-Ray / Q000379:methods; D015195:Drug Design; D006801:Humans; D007249:Inflammation; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D015394:Molecular Structure; D010078:Oxazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D020033:Protein Isoforms; D013329:Structure-Activity Relationship
chemical_list: D048588:Benzoxazines; D010078:Oxazines; D020033:Protein Isoforms; D019869:Phosphatidylinositol 3-Kinases