[CD20 antigen of Hodgkin and Reed-Sternberg cells as possible prognostic factor in patients with Hodgkin's lymphoma--preliminary reports].
THE AIM of the study was to asses the validity of CD20 expression on H-RS cells as independent prognostic factor in patients with Hodgkin's lymphoma.


METHODS
72 patients (44 men and 28 women) between 15 and 73 y.o. (av. 36,5 y.o) treated in the Department of Oncological Chemotherapy of Silesian Medical Academy (1992-2002) were included in the study. Tissue specimens were immunohistochemically stained with monoclonal antibodies for CD20.


RESULTS
Analyzed group was classified according to histological subtype as follows: LP - n = 3, NS - n = 26, MC - n = 23, LR - n = 7 and LD - n = 13. Overall survival (OS) for the group was from 3 to 169 months (av. 64,5), disease free survival (DFS) - 4 to 167 months (av. 44,8) respectively. CD20 expression on H-RS cells was found in 13,9% subjects. Statistically significant difference (p = 0,0001) in DFS has been found between groups with and without CD20 expression. Results of this study are preliminary and should be confirmed in larger prospective studies.
Rygoł
Barbara
B
Klinika Chorób Wewnetrznych i Chemioterapii Onkologicznej Slaskiej Akademii Medycznej w Katowicach.
Krzemień
Sławomira
S
Pajak
Jacek
J
Konicki
Piotr
P
Kowal
Elzbieta
E
Spychałowicz
Wojciech
W
Mykała-Cieśla
Joanna
J
Gasińska
Teresa
T
Krajewski-Siuda
Krzysztof
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D018951:Antigens, CD20 / Q000096:biosynthesis*; D005260:Female; D015870:Gene Expression; D006689:Hodgkin Disease / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016539:Reed-Sternberg Cells / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D018951:Antigens, CD20