Visual PET/CT scoring for nonspecific 18F-FDG uptake in the differentiation of early malignant and benign esophageal lesions.
OBJECTIVE
The purpose of our study was to evaluate a visual PET/CT scoring system for the differentiation of benign and early malignant esophageal uptake.


METHODS
Thirty-six consecutive patients with precancerous or early malignant esophageal lesions including Barrett's esophagus, Tis, T1, and T2 adenocarcinomas were eligible. Findings of these patients were compared with 66 patients who had reported increased esophageal (18)F-FDG uptake due to benign esophageal disorders. Lesions were evaluated with scores using the following characteristics in PET/CT: FDG uptake intensity (low = 0, moderate = 1, high = 2), FDG uptake eccentricity (concentric = 0, eccentric = 1), FDG uptake focality (diffuse = 0, segmental = 1, focal = 2), esophageal thickness on the CT component (normal = 0, thickening = 1, mass = 2), and location (distal third of the esophagus = 0, middle third of the esophagus = 1, proximal third of the esophagus = 2).


RESULTS
Early malignant lesions had higher scores in FDG uptake intensity (p = 0.003; chi-square), eccentricity (p < 0.001), and focality (p < 0.001) compared with benign lesions. No significant difference was seen in esophageal thickness on CT (p = 0.168) and in location of the lesion (p = 0.291). Binary logistic regression analysis with a stepwise forward inclusion of all score components including the maximum standardized uptake value (SUV) of the lesions revealed that a total score combining eccentricity and focality scores has the highest accuracy of predicting early malignant disease. Using a threshold of equal or higher than 2 in the combined total focality-eccentricity score, the sensitivity was 83.3% and specificity was 68.2% for predicting early malignant disease.


CONCLUSIONS
Focality and eccentricity of FDG uptake prove to be valuable PET/CT characteristics for the differentiation of nonspecific FDG uptake in the esophagus.
Roedl
Johannes B
JB
Division of Abdominal and Interventional Radiology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St., Boston, MA 02114, USA. johannes.roedl@gmail.com
Colen
Rivka R
RR
King
Kevin
K
Fischman
Alan J
AJ
Mueller
Peter R
PR
Blake
Michael A
MA
D000368:Aged; D019540:Area Under Curve; D016009:Chi-Square Distribution; D003937:Diagnosis, Differential; D004935:Esophageal Diseases / Q000000981:diagnostic imaging*; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000000981:diagnostic imaging; D012372:ROC Curve; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18