title: Does autofluorescence imaging videoendoscopy system improve the colonoscopic polyp detection rate?--a pilot study.
abstract: OBJECTIVE
  Colonoscopy is considered the gold standard for the detection of colorectal polyps; however, polyps can be missed with conventional white light (WL) colonoscopy. The aim of this pilot study was to evaluate whether a newly developed autofluorescence imaging (AFI) system can detect more colorectal polyps than WL.
  
  
  METHODS
  A modified back-to-back colonoscopy using AFI and WL was conducted for 167 patients in the right-sided colon including cecum, ascending and transverse colon by a single experienced colonoscopist. The patient was randomized to undergo the first colonoscopy with either AFI or WL (group A: AFI-WL, group B: WL-AFI). The time needed for both insertion and examination for withdrawal and all lesions detected in the right-sided colon were recorded.
  
  
  RESULTS
  Eighty-three patients were randomized to group A and 84 to group B. The total number of polyps detected by AFI and WL colonoscopy was 100 and 73, respectively. The miss rate for all polyps with AFI (30%) was significantly less than that with WL (49%) (P= 0.01).
  
  
  CONCLUSIONS
  AFI detects more polyps in the right-sided colon compared to WL colonoscopy.
authors.affiliation: Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Matsuda
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Saito
authors.forename: Kuang-I
authors.initials: KI
authors.lastname: Fu
authors.forename: Toshio
authors.initials: T
authors.lastname: Uraoka
authors.forename: Nozomu
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakajima
authors.forename: Hisatomo
authors.initials: H
authors.lastname: Ikehara
authors.forename: Yumi
authors.initials: Y
authors.lastname: Mashimo
authors.forename: Tadakazu
authors.initials: T
authors.lastname: Shimoda
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Murakami
authors.forename: Adolfo
authors.initials: A
authors.lastname: Parra-Blanco
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujimori
authors.forename: Daizo
authors.initials: D
authors.lastname: Saito
mesh_terms: D000368:Aged; D003111:Colonic Polyps / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003113:Colonoscopy / Q000379:methods*; D005188:False Negative Reactions; D005260:Female; D005453:Fluorescence; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011237:Predictive Value of Tests; D014741:Video Recording