title: Enhanced nonenzymatic glycation of eye lens proteins in experimental diabetes mellitus: an approach for the study of protein alterations as mediators of normal aging phenomena.
abstract: The levels of advanced nonenzymatic glycation endproducts (ACE) were investigated by spectrofluorimetry in eye lens proteins obtained from rats with experimental diabetes of 3 and 6 months duration and from normal age-matched control rats. Diabetic animals showed higher AGE levels at both times studied. However the older control animals showed protein ACE levels comparable to those of the experimental 3 months diabetic group. These data suggest that a pathological phenomenon such as enhanced nonenzymatic glycation, associated to diabetic hyperglycemia, can be considered as a process leading to an accelerated aging of proteins. Thus experimental diabetes mellitus may be used as a model to investigate physiological protein senescence.
authors.affiliation: Universitá di Roma La Sapienza, Viale del Policlinico, I-00161 Roma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Sensi
authors.forename: F
authors.initials: F
authors.lastname: Pricci
authors.forename: C
authors.initials: C
authors.lastname: Pugliese
authors.forename: M G
authors.initials: MG
authors.lastname: De Rossi
authors.forename: F S
authors.initials: FS
authors.lastname: Celi
authors.forename: A
authors.initials: A
authors.lastname: Cristina
authors.forename: S
authors.initials: S
authors.lastname: Morano
authors.forename: D
authors.initials: D
authors.lastname: Andreani
authors.forename: U
authors.initials: U
authors.lastname: Di Mario