Synthesis of N-substituted derivatives of 8,11-dimethyl-3,5-dioxo-4-azatricyclo[5.2.2.0(2,6)]undec-8-en-1-yl acetate and screening of cytotoxic activity of selected azatricycloundecane compounds.
This paper reports the synthesis of a number of aminoalkyl derivatives of 8,11-dimethyl-3,5-dioxo-4-azatricyclo[5.2.2.0(2,6)]undec-8-en-1-yl acetate and 1,11 -dimethyl-4-azatricyclo [5.2.2.0(2,6)]undecan-3,5,8-tri-one. Fourteen compounds were prepared and the in vitro cytotoxic activities were evaluated against human cancer cell lines originating from solid tumors in the National Cancer Institute, Bethesda, MD, USA.
Kossakowski
Jerzy
J
Department of Medical Chemistry, Medical University, Warszawa, Poland. jerzy.kossakowski@am.edu.pl
Kuran
Bozena
B
D000473:Alkanes / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013329:Structure-Activity Relationship
D000473:Alkanes; D000970:Antineoplastic Agents; D001372:Aza Compounds; C022884:undecane