[Temperature effect of rheological parameters and pharmaceutical availability of diclofenak sodium salt from hydrogel products made on carbopol base for topical use].
The aim of the carried out investigations was to state temperature effect of conventional carried out results of pharmaceutical availability valuation. Rheological parameters were tested in temperature of 32 and 37 degrees C in market hydrogel products for topical use made on carbopol base with diclofenac sodium salt. The kinetics of diclofenac sodium salt release with Hanson extraction cells through a dialysis membrane SpectraPor was tested in vitro. Viscosity parameters were determined with cone-plate digital rheometer.
Pluta
Janusz
J
Katedra Technologii Postaci Leku Akademii Medycznej we Wrocławiu.
Lepka
Magdalena
M
Michalska
Ewelina
E
D000180:Acrylic Resins; D000287:Administration, Topical; D004008:Diclofenac / Q000008:administration & dosage* / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D008567:Membranes, Artificial; D011145:Polyvinyls / Q000737:chemistry*; D012212:Rheology; D013696:Temperature
D000180:Acrylic Resins; D020100:Hydrogels; D008567:Membranes, Artificial; D011145:Polyvinyls; C006912:carboxypolymethylene; D004008:Diclofenac