Isostructural self-assembly of 2'-deoxyguanosine derivatives in aqueous and organic media.
We report the self-assembly of a hydrophilic 8-(m-acetylphenyl)-2'-deoxyguanosine (mAG) derivative into a discrete and thermally stable hexadecameric supramolecule in aqueous media. We demonstrate that this hexadecamer is isostructural to the one formed by a related lipophilic derivative in organic media. This mAG moiety represents a rare example of a small-molecule recognition motif that is capable of assembling isostructurally and with high fidelity in both organic and aqueous media.
García-Arriaga
Marilyn
M
Department of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, Puerto Rico.
Hobley
Gerard
G
Rivera
José M
JM
D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000737:chemistry*; D007536:Isomerism; D015394:Molecular Structure; D012997:Solvents / Q000737:chemistry; D014867:Water / Q000737:chemistry*
D012997:Solvents; D014867:Water; D003849:Deoxyguanosine