title: Effects of anisomycin on inhibitory avoidance in male and female CD1 mice.
abstract: The antibiotic anisomycin inhibits protein synthesis, which much research has suggested is required for the formation of long-term memory. The present work studied the effects of acute subcutaneous administration of anisomycin on the consolidation of memory in an inhibitory avoidance task in CD1 mice of both sexes. The animals were separated by sex and randomly distributed into three groups: two groups were injected with 150 mg/kg anisomycin, one immediately after the training phase and the other 24 h later, while the control group received saline. The interval between training and test was four days. Anisomycin administrated immediately after training produced statistically significant impairment of memory, which was not observed when the drug was administered 24 h after training. No sex differences were observed in the effects of anisomycin. These results extend to female mice the memory impairing effects of anisomycin previously observed in males and endorse the hypothesis that the establishment of long-term memory depends on protein synthesis shortly after training.
authors.affiliation: Facultad de Psicología-Departamento de Facultad de Psicobiología, Universitat de València, Valencia, Spain. santiago.monleon@uv.es
authors.forename: Santiago
authors.initials: S
authors.lastname: Monleón Verdú
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Arenas Fenollar
authors.forename: Concepción
authors.initials: C
authors.lastname: Vinader Caerols
authors.forename: Aránzazu
authors.initials: A
authors.lastname: Ferrer Añó
authors.forename: Andrés
authors.initials: A
authors.lastname: Parra Guerrero
mesh_terms: D000818:Animals; D000841:Anisomycin / Q000008:administration & dosage / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects*; D005260:Female; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D009433:Neural Inhibition / Q000187:drug effects*; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D011500:Protein Synthesis Inhibitors; D000841:Anisomycin