Efficient parallel synthesis of macrocyclic peptidomimetics.
A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A key feature of the method is access to broad chemical and conformational diversity. Synthesis and mechanistic studies on the macrocyclization step are reported.
Marsault
Eric
E
Tranzyme Pharma Inc. 3001, 12e av. Nord, Sherbrooke, Que., Canada J1H5N4. emarsault@tranzyme.com
Hoveyda
Hamid R
HR
Gagnon
René
R
Peterson
Mark L
ML
Vézina
Martin
M
Saint-Louis
Carl
C
Landry
Annick
A
Pinault
Jean-François
JF
Ouellet
Luc
L
Beauchemin
Sophie
S
Beaubien
Sylvie
S
Mathieu
Axel
A
Benakli
Kamel
K
Wang
Zhigang
Z
Brassard
Martin
M
Lonergan
David
D
Bilodeau
François
F
Ramaseshan
Mahesh
M
Fortin
Nadia
N
Lan
Ruoxi
R
Li
Shigui
S
Galaud
Fabrice
F
Plourde
Véronique
V
Champagne
Manon
M
Doucet
Annie
A
Bhérer
Patrick
P
Gauthier
Maude
M
Olsen
Gilles
G
Villeneuve
Gérald
G
Bhat
Shridhar
S
Foucher
Laurence
L
Fortin
Daniel
D
Peng
Xiaowen
X
Bernard
Sylvain
S
Drouin
Alexandre
A
Déziel
Robert
R
Berthiaume
Gilles
G
Dory
Yves L
YL
Fraser
Graeme L
GL
Deslongchamps
Pierre
P
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D019281:Dimerization; D004151:Dipeptides; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry; D010456:Peptides, Cyclic / Q000737:chemistry*; D012834:Silver / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004151:Dipeptides; D010455:Peptides; D010456:Peptides, Cyclic; D012834:Silver