Comment on "Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain".
Manganas et al. (Reports, 9 November 2007, p. 980) reported the discovery of a biomarker specific for neural progenitor cells detectable using magnetic resonance spectroscopy. A new algorithm was developed to extract the biomarker from noisy in vivo data. We question how this algorithm was validated, because the biomarker overlaps with peaks from nonspecific lipid signals.
Jansen
Jacobus F A
JF
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. jansenjfa@gmail.com
Gearhart
John D
JD
Bulte
Jeff W M
JW
D000465:Algorithms; D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D001921:Brain / Q000166:cytology*; D053595:Embryonic Stem Cells / Q000737:chemistry / Q000166:cytology; D006801:Humans; D008055:Lipids / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D051379:Mice; D009474:Neurons / Q000737:chemistry / Q000166:cytology*; D013234:Stem Cells / Q000737:chemistry / Q000166:cytology*
D015415:Biomarkers; D008055:Lipids