Catalytic aerobic oxidation of substituted 8-methylquinolines in Pd(II)-2,6-pyridinedicarboxylic acid systems.
The ability of Pd(II) complexes derived from 2,6-pyridinedicarboxylic acids to catalyze homogeneous regioselective aerobic oxidation of 5- and 6-substituted 8-methylquinolines in AcOH-Ac(2)O solution to produce corresponding 8-quinolylmethyl acetates in high yield was demonstrated; corresponding 8-quinoline carboxylic acids are minor reaction products.
Zhang
Jing
J
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
Khaskin
Eugene
E
Anderson
Nicholas P
NP
Zavalij
Peter Y
PY
Vedernikov
Andrei N
AN