title: Prenatal diagnosis of anoxic cerebral lesions caused by profound fetal anemia secondary to maternal red blood cell alloimmunization.
abstract: BACKGROUND
  The long-term neurological prognosis of severe fetal anemia is usually considered favorable, especially when fetal hydrops regresses after successful in utero transfusion.
  
  
  METHODS
  We report two cases of prenatally diagnosed fetal cerebral anoxic lesions associated with severe fetal anemia despite appropriate and successful treatment by in utero transfusion. The two pregnancies were terminated.
  
  
  CONCLUSIONS
  Profound fetal anemia may cause anoxic lesions of the fetal brain that may be diagnosed prenatally. If new onset ventriculomegaly is observed on ultrasonography after in utero transfusion for severe fetal anemia, anoxic lesions could be suspected.
authors.affiliation: Centre National de Référence en Hémobiologie Périnatale, Hôpital Saint-Antoine, Paris, France. bruno.carbonne@sat.aphp.fr
authors.forename: Bruno
authors.initials: B
authors.lastname: Carbonne
authors.forename: Amélie
authors.initials: A
authors.lastname: Nguyen
authors.forename: Evelyne
authors.initials: E
authors.lastname: Cynober
authors.forename: Vanina
authors.initials: V
authors.lastname: Castaigne
authors.forename: Anne
authors.initials: A
authors.lastname: Cortey
authors.forename: Yves
authors.initials: Y
authors.lastname: Brossard
mesh_terms: D000328:Adult; D000740:Anemia / Q000097:blood / Q000000981:diagnostic imaging / Q000276:immunology*; D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000276:immunology*; D006801:Humans; D002534:Hypoxia, Brain / Q000097:blood / Q000000981:diagnostic imaging / Q000276:immunology*; D007626:Kell Blood-Group System / Q000276:immunology*; D011247:Pregnancy; D012203:Rh Isoimmunization / Q000150:complications* / Q000000981:diagnostic imaging; D016216:Ultrasonography, Prenatal
chemical_list: D007626:Kell Blood-Group System