title: [Expression of human leukocyte antigen-DR in idiopathic pulmonary fibrosis].
abstract: OBJECTIVE
  To study the expression of human leukocyte antigen (HLA)-DR in the lungs of the patients with idiopathic pulmonary fibrosis (IPF), and to explore the possible autoimmunity mechanisms of lung fibrosis.
  
  
  METHODS
  Methods Immunohistochemistry (SP method) was used to detect the expression of HLA-DR in the lung specimens from 10 IPF patients and in 5 specimens of normal lung tissue immediately adjacent to lung carcinomas as controls.
  
  
  RESULTS
  HLA-DR antigens were expressed in the hyperplastic bronchi-alveolar epithelial cells in IPF, but not in the epithelial cells of the normal control lung tissues. The accumulated positive scores of HLA-DR of the IPF group was 27, significantly higher than that of the control group (2, Z = - 3.002, P = 0.001).
  
  
  CONCLUSIONS
  Inappropriate HLA-DR expression is present in the bronchi -alveolar epithelium in IPF. Immune dysfunction may play an important role in the development of IPF.
authors.affiliation: Department of Geriatric Medicine, Peking University First Hospital, Beijing 100034, China.
authors.forename: Lian-fang
authors.initials: LF
authors.lastname: Ni
authors.forename: Jia
authors.initials: J
authors.lastname: Na
authors.forename: Rui
authors.initials: R
authors.lastname: Deng
authors.forename: Rui
authors.initials: R
authors.lastname: Wu
authors.forename: Xin-min
authors.initials: XM
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D005260:Female; D006684:HLA-DR Antigens / Q000096:biosynthesis* / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008175:Lung Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D006684:HLA-DR Antigens