title: Baseline activities of four biomarkers in three life-stages of the amphipod, Leptocheirus plumulosus.
abstract: This study investigated differences in baseline levels of four cellular biomarkers (glutathione (GSH), lipid peroxidation (LPx), acetylcholinesterase (AChE), and cholesterol (CHL)) in the larval, juvenile, and adult stages of the estuarine amphipod, Leptocheirus plumulosus. Glutathione, LPx, and AChE exhibited the same pattern of decreasing levels with increasing developmental stage. Cholesterol showed an inverse relationship of increasing levels with increasing developmental stages. This research provides valuable background information that may be used in future assessments of amphipod biomarker research.
authors.affiliation: JHT Incorporated, Contractor for the National Ocean Service, Orlando, Florida, USA. jen.hoguet@noaa.gov
authors.forename: Jennifer
authors.initials: J
authors.lastname: Hoguet
authors.forename: Peter B
authors.initials: PB
authors.lastname: Key
mesh_terms: D000110:Acetylcholinesterase / Q000032:analysis / Q000378:metabolism; D033304:Amphipoda / Q000187:drug effects* / Q000254:growth & development; D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism*; D002784:Cholesterol / Q000032:analysis / Q000378:metabolism; D004784:Environmental Monitoring; D005978:Glutathione / Q000032:analysis / Q000378:metabolism; D007928:Lethal Dose 50; D008018:Life Cycle Stages; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008954:Models, Biological; D012989:Soil Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D015415:Biomarkers; D012989:Soil Pollutants; D014874:Water Pollutants, Chemical; D002784:Cholesterol; D000110:Acetylcholinesterase; D005978:Glutathione