Triazole-linked analogue of deoxyribonucleic acid ((TL)DNA): design, synthesis, and double-strand formation with natural DNA.
A new triazole-linked analogue of DNA ((TL)DNA) has been designed and synthesized using click chemistry. The chain elongation reaction using copper-catalyzed Huisgen cycloaddition was successful and gave the artificial oligonucleotide that formed a stable double strand with the complementary strand of natural DNA.
Isobe
Hiroyuki
H
Department of Chemistry, Tohoku University, Aoba-ku, Sendai 980-8578, Japan. isobe@mail.tains.tohoku.ac.jp
Fujino
Tomoko
T
Yamazaki
Naomi
N
Guillot-Nieckowski
Marine
M
Nakamura
Eiichi
E
D003300:Copper / Q000737:chemistry; D003500:Cyclization; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D013941:Thymine / Q000031:analogs & derivatives / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
D009841:Oligonucleotides; D014230:Triazoles; D003300:Copper; D004247:DNA; D013941:Thymine