title: Fatty acid deficiency profile in children with food allergy managed with elimination diets.
abstract: OBJECTIVE
  To evaluate plasma fatty acid (FA) composition of children with food allergy undergoing elimination diets that avoided the offending antigens.
  
  
  METHODS
  Twenty-five children (14 male, 11 female) aged 3.8 +/- 1.6 years (range 2-7 years) affected of multiple food allergy and managed with elimination diets participated in a cross-sectional study. Results of plasma fatty acids were compared with data obtained in 61 healthy children.
  
  
  RESULTS
  The patients had significantly lower values for plasma content in total polyunsaturated fatty acids, omega3 polyunsaturated fatty acids and long-chain omega3 polyunsaturated fatty acids (p < 0.001) and particularly, in eicosapentaenoic acid (EPA) (20:5omega3) and docosahexaenoic acid (DHA) (22:6omega3) (p < 0.001). Moreover, all established indices (essential fatty acid [EFA] index ((omega3 +omega6)/(omega7 +omega9)) (p < 0.001) and sufficiency of docosahexaenoic acid index (C22:6omega3/C22:5omega6) (p < 0.001)) confirmed the presence of EFA deficiency.
  
  
  CONCLUSIONS
  Children with food allergy managed with restricted intake of foods such as milk, egg, fish and vegetables are at risk of developing a deficiency in EFA and particularly in omega3 long-chain polyunsaturated fatty acids, which are especially necessary for adequate growth, neurological development and cardiovascular health.
authors.affiliation: Divisions of Metabolism, Department of Pediatrics, Hospital de Cruces, Basque University School of Medicine, Bilbao, País Vasco, Spain. luisjose.aldamiz-echevarazuara@osakidetza.net
authors.forename: Luis
authors.initials: L
authors.lastname: Aldámiz-Echevarría
authors.forename: Agurtzane
authors.initials: A
authors.lastname: Bilbao
authors.forename: Fernando
authors.initials: F
authors.lastname: Andrade
authors.forename: Javier
authors.initials: J
authors.lastname: Elorz
authors.forename: José Angel
authors.initials: JA
authors.lastname: Prieto
authors.forename: Juan
authors.initials: J
authors.lastname: Rodríguez-Soriano
mesh_terms: D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004032:Diet / Q000706:statistics & numerical data; D004035:Diet Therapy / Q000009:adverse effects*; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D005260:Female; D005512:Food Hypersensitivity / Q000178:diet therapy*; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000209:etiology*
chemical_list: D015525:Fatty Acids, Omega-3