title: Therapeutic dimensions of ACE inhibitors--a review of literature and clinical trials.
abstract: In the 1970s, pharmacological therapy interrupting the renin-angiotensin system was considered beneficial for patients with high-renin hypertension. This gave rise to the development of ACE inhibitors. Surprisingly, the ACE inhibitors proved to be effective not only in patients with high renin hypertension, but also in many patients with normal levels of plasma renin activity. At present ACE inhibitors have a significant position in a wide range of chronic illnesses such as atherosclerosis, hypertension, myocardial infarction, diabetic complications, stroke etc. They are combined safely with drugs like angiotensin receptor blockers, calcium channel blockers and thiazides with varying degree of benefits. Though they are safe drugs, patients need monitoring for renal insufficiency, hypotension, hyperkalemia etc. The safety of these drugs in paediatrics patients is not established. It is better to avoid these drugs during pregnancy.
authors.affiliation: Department of Medicine, Manipal Teaching Hospital, Pokhara, Nepal. mmukhyaprana@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Prabhu
authors.forename: S
authors.initials: S
authors.lastname: Palaian
authors.forename: A
authors.initials: A
authors.lastname: Malhotra
authors.forename: P
authors.initials: P
authors.lastname: Ravishankar
authors.forename: D
authors.initials: D
authors.lastname: Bista
authors.forename: R
authors.initials: R
authors.lastname: Almeida
authors.forename: P
authors.initials: P
authors.lastname: Mishra
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy; D048909:Diabetes Complications / Q000188:drug therapy; D006801:Humans
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors