title: Effect of IgG immunoadsorption on serum cytokines in MG and LEMS patients.
abstract: We investigated the effect of IgG immunoadsorption (IA) on cytokine network in patients with treatment-resistant Myasthenia Gravis (MG) and Lambert-Eaton Syndrome (LEMS). We observed upregulation of interleukin (IL)-10, an anti-inflammatory and B cells growth factor, and reduction of pro-inflammatory factors such as IL-18 and IL-17, in both MG and LEMS after IA. Our observation suggests that the massive removal of antibodies might induce modifications of the cytokine balance linked to T and B cells mediated autoimmunity.
authors.affiliation: Neurology IV, Neurological Institute Foundation "Carlo Besta", Via Celoria 11, 20133 Milan, Italy. baggi@istituto-besta.it
authors.forename: Fulvio
authors.initials: F
authors.lastname: Baggi
authors.forename: Federica
authors.initials: F
authors.lastname: Ubiali
authors.forename: Sara
authors.initials: S
authors.lastname: Nava
authors.forename: Valeria
authors.initials: V
authors.lastname: Nessi
authors.forename: Francesca
authors.initials: F
authors.lastname: Andreetta
authors.forename: Andrea
authors.initials: A
authors.lastname: Rigamonti
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Maggi
authors.forename: Renato
authors.initials: R
authors.lastname: Mantegazza
authors.forename: Carlo
authors.initials: C
authors.lastname: Antozzi
mesh_terms: D000293:Adolescent; D000328:Adult; D020865:Calcium Channels, P-Type / Q000276:immunology; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007163:Immunosorbent Techniques; D015624:Lambert-Eaton Myasthenic Syndrome / Q000097:blood* / Q000276:immunology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood* / Q000276:immunology / Q000628:therapy*; D011863:Radioimmunoassay / Q000379:methods; D011950:Receptors, Cholinergic / Q000276:immunology
chemical_list: D020865:Calcium Channels, P-Type; D016207:Cytokines; D007074:Immunoglobulin G; D011950:Receptors, Cholinergic