Does autofluorescence imaging videoendoscopy system improve the colonoscopic polyp detection rate?--a pilot study.
OBJECTIVE
Colonoscopy is considered the gold standard for the detection of colorectal polyps; however, polyps can be missed with conventional white light (WL) colonoscopy. The aim of this pilot study was to evaluate whether a newly developed autofluorescence imaging (AFI) system can detect more colorectal polyps than WL.


METHODS
A modified back-to-back colonoscopy using AFI and WL was conducted for 167 patients in the right-sided colon including cecum, ascending and transverse colon by a single experienced colonoscopist. The patient was randomized to undergo the first colonoscopy with either AFI or WL (group A: AFI-WL, group B: WL-AFI). The time needed for both insertion and examination for withdrawal and all lesions detected in the right-sided colon were recorded.


RESULTS
Eighty-three patients were randomized to group A and 84 to group B. The total number of polyps detected by AFI and WL colonoscopy was 100 and 73, respectively. The miss rate for all polyps with AFI (30%) was significantly less than that with WL (49%) (P= 0.01).


CONCLUSIONS
AFI detects more polyps in the right-sided colon compared to WL colonoscopy.
Matsuda
Takahisa
T
Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Saito
Yutaka
Y
Fu
Kuang-I
KI
Uraoka
Toshio
T
Kobayashi
Nozomu
N
Nakajima
Takeshi
T
Ikehara
Hisatomo
H
Mashimo
Yumi
Y
Shimoda
Tadakazu
T
Murakami
Yoshitaka
Y
Parra-Blanco
Adolfo
A
Fujimori
Takahiro
T
Saito
Daizo
D
D000368:Aged; D003111:Colonic Polyps / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003113:Colonoscopy / Q000379:methods*; D005188:False Negative Reactions; D005260:Female; D005453:Fluorescence; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011237:Predictive Value of Tests; D014741:Video Recording