Investigation of Alternanthera repens and Bidens odorata on gastrointestinal disease.
Alternanthera repens and Bidens odorata are used as medication for gastrointestinal diseases today, mainly in relation to diarrhea; therefore, pharmacological tests with aqueous and ethanol extracts of both species were carried out in mice. Using charcoal meal, the activity of the four extracts on intestinal motility was determined, finding that they inhibit the advance of the gastrointestinal content. Also, the lethal media doses were estimated in order to examine the plants' safety. The data confirmed the validity of the medicinal use for both plant species, contributing to explain the use of these plants as antidiarrheal agents in Mexican traditional medicine.
Astudillo-Vázquez
Adela
A
Departamento de Biofísica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Casco de Santo Tomás 11340, México D F, México. adelaav@correo.unam.mx
Dávalos Valle
Hortencia
H
De Jesús
Leyvert
L
Herrera
Guadalupe
G
Navarrete
Andrés
A
D027703:Amaranthaceae; D000818:Animals; D000930:Antidiarrheals / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D031176:Bidens; D003967:Diarrhea / Q000188:drug therapy; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
D000930:Antidiarrheals; D010936:Plant Extracts