title: Dietary red chilli (Capsicum frutescens L.) is insulinotropic rather than hypoglycemic in type 2 diabetes model of rats.
abstract: The present study was conducted to clarify whether a low or a high, but tolerable, dietary dose of red chilli (RC) can ameliorate the diabetes related complications in a high-fat (HF) diet-fed streptozotocin (STZ)-induced type 2 diabetes model of rats. Five-week-old male Sprague Dawley rats were fed a HF diet for 2 weeks then randomly divided into four groups namely: normal control (NC), diabetic control (DBC), red chilli low (RCL, 0.5%) and red chilli high (RCH, 2.0%) groups. Diabetes was induced by an intraperitoneal (i.p.) injection of STZ (40 mg/kg BW) in all groups except the NC group. After 4 weeks feeding of experimental diets, the fasting blood glucose concentrations in both RC fed groups were not significantly different. The serum insulin concentration was significantly (p < 0.05) increased in the RCH group compared with the DBC and RCL groups. Blood HbA1c, liver weight, liver glycogen and serum lipids were not influenced by the feeding of RC-containing diets. The data of this study suggest that 2% dietary RC is insulinotropic rather than hypoglycemic at least in this experimental condition.
authors.affiliation: Department of Food and Nutrition, Seoul National University, Seoul 151-742, South Korea. sislam1974@yahoo.com
authors.forename: Md Shahidul
authors.initials: MS
authors.lastname: Islam
authors.forename: Haymie
authors.initials: H
authors.lastname: Choi
mesh_terms: D000821:Animal Feed; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002212:Capsicum / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000178:diet therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000178:diet therapy*; D004032:Diet; D004041:Dietary Fats; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005508:Food Deprivation / Q000502:physiology; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D007004:Hypoglycemic Agents / Q000145:classification / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000502:physiology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008112:Liver Glycogen / Q000032:analysis / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000145:classification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D008112:Liver Glycogen; D010936:Plant Extracts