Streptopyrrolidine, an angiogenesis inhibitor from a marine-derived Streptomyces sp. KORDI-3973.
Streptopyrrolidine, a benzyl pyrrolidine derivative, was isolated as an angiogenesis inhibitor from the fermentation broth of a marine Streptomyces sp. isolated from the deep sea sediment. Its structure was elucidated by extensive 2D NMR and mass spectroscopic analyses. Streptopyrrolidine exhibited significant anti-angiogenesis activity.
Shin
Hee Jae
HJ
Marine Natural Products Laboratory, Korea Ocean Research & Development Institute, Ansan P.O. Box 29, Seoul 425-600, Republic of Korea. shinhj@kordi.re.kr
Kim
Tae Sik
TS
Lee
Hyi-Seung
HS
Park
Jung Youl
JY
Choi
In-Kwon
IK
Kwon
Ho Jeong
HJ
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D011759:Pyrrolidines / Q000737:chemistry / Q000494:pharmacology*; D012623:Seawater / Q000382:microbiology; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000302:isolation & purification; D014471:Umbilical Veins
D020533:Angiogenesis Inhibitors; D011759:Pyrrolidines; D004121:Dimethyl Sulfoxide