A cytotoxic and apoptosis-inducing sesquiterpenoid isolated from the aerial parts of Artemisia princeps PAMPANINI (Sajabalssuk).
Repeated silica gel and octadecyl silica gel (ODS) column chromatography of the aerial parts of Artemisia princeps PAMPANINI (Sajabalssuk) led to the isolation of a new sesquiterpenoid, 3-((S)-2-methylbutyryloxy)-costu-1(10),4(5)-dien-12,6 alpha-olide (2), along with two previously reported sesquiterpenoids: 8 alpha-angeloyloxy-3beta,4 beta-epoxy-6 beta H,7 alpha H,8 beta H-guaia-1(10),11(13)-dien-12,6 alpha-olide (1, carlaolide B) and 3beta,4 beta-epoxy-8 alpha-isobutyryloxy-6 beta H,7 alpha H,8 beta H-guaia-1(10),11(13)-dien-12,6 alpha-olide (3, carlaolide A). The structure of compound 2 was elucidated by spectroscopic data analysis, including one dimensional (1D) and two dimensional (2D) nuclear magnetic resonance (NMR) experiments. Of the isolates, compound 2 exhibited potent cytotoxicity against human cervix adenocarcinoma cells and induced apoptosis.
Bang
Myun-Ho
MH
The Skin Biotechnology Center, Kyung Hee University, Suwon, Korea.
Han
Min-Woo
MW
Song
Myoung-Chong
MC
Cho
Jin-Gyeong
JG
Chung
Hae-Gon
HG
Jeong
Tae-Sook
TS
Lee
Kyung-Tae
KT
Choi
Myung-Sook
MS
Kim
Se-Young
SY
Baek
Nam-In
NI
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology*; D017209:Apoptosis / Q000235:genetics*; D019306:Artemisia / Q000737:chemistry*; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D006801:Humans; D015394:Molecular Structure; D045789:Sesquiterpenes, Guaiane / Q000302:isolation & purification* / Q000633:toxicity; D014407:Tumor Cells, Cultured
D045789:Sesquiterpenes, Guaiane