Windows based general PBPK/PD modeling software.
A physiologically based pharmacokinetic (PBPK) model and program (called PostNatal) was developed which focuses on postnatal growth. Algorithms defining organ/tissue growth curves from birth through adulthood for male and female humans, dogs, rats, and mice are utilized to calculate the appropriate weight and blood flow for the internal organs/tissues. This Windows based program is actually four linked PBPK models with each PBPK model acting independently or totally integrated with the others through metabolism by first order or Michaelis-Menten kinetics. Data fitting is accomplished by a weighted least square regression algorithm. The model includes linkages for the simulation of pharmacodynamic (PD) effects.
Luecke
Richard H
RH
Department of Chemical Engineering, University of Missouri-Columbia, Columbia, MO 65231, USA.
Pearce
Bruce A
BA
Wosilait
Walter D
WD
Doerge
Daniel R
DR
Slikker
William
W
Young
John F
JF
D000465:Algorithms; D000818:Animals; D004285:Dogs; D005260:Female; D006128:Growth; D006801:Humans; D016018:Least-Squares Analysis; D008297:Male; D051379:Mice; D008954:Models, Biological; D017711:Nonlinear Dynamics; D010599:Pharmacokinetics; D000069437:Pharmacological Phenomena; D051381:Rats; D012984:Software