Autosomal STR variations in three endogamous populations of West Bengal, India.
The allele frequency distribution of 15 autosomal STR loci was determined using AmpFlSTR Identifiler kit in three endogamous caste populations namely, Rajbanshi, Paliya and Dhimal from northern regions of West Bengal, India. The study includes 13 CODIS STR core markers, i.e., D8S1179, D3S1358, D21S11, D7S820, CSF1PO, vWA, TPOX, D18S51, THO1, D13S317, D16S539, D5S818, FGA and two other loci D19S433 and D2S1338. All the loci followed Hardy-Weinberg equilibrium, except loci D8S1179, vWA and FGA in Rajbanshi population, D13S317 in Paliya population and D16S539 and TPOX in Dhimal population. The allele 12 in CSF1PO in Rajbanshi population and allele nine in THO1 in Paliya as well as in Dhimal population were found to be most frequent. All the 15 STR loci studied were found to be highly polymorphic with respect to observed heterozygosity values. Population differentiation tests revealed highly significant differences at several loci suggesting the endogamous nature of studied populations. STR allele frequency data on Dhimal population presented here is a unique contribution to the existing DNA data base on Indian population. To the best of our present knowledge, hitherto Dhimal Population has not been explored genetically for generating forensic data on STR markers.
Roy
S
S
National DNA Analysis Center, Central Forensic Science Laboratory, 30-Gorachand Road, Park Circus, Kolkata 700014, West Bengal, India.
Eaaswarkhanth
M
M
Dubey
B
B
Haque
I
I
D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D007194:India / Q000208:ethnology; D018895:Microsatellite Repeats / Q000235:genetics*