Breast cancer stem cells: implications for therapy of breast cancer.
The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumour-associated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells.
Morrison
Brian J
BJ
Queensland Institute of Medical Research, Royal Brisbane Hospital Post Office, Brisbane 4029, Australia. brian.morrison@qimr.edu.au
Schmidt
Chris W
CW
Lakhani
Sunil R
SR
Reynolds
Brent A
BA
Lopez
J Alejandro
JA
D000951:Antigens, Neoplasm / Q000378:metabolism; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000166:cytology; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D009362:Neoplasm Metastasis; D014411:Neoplastic Stem Cells / Q000166:cytology* / Q000473:pathology; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology; D013997:Time Factors; D016896:Treatment Outcome
D000951:Antigens, Neoplasm