title: HIV RNA viral load and CD4+ T-cell counts in HIV-infected pregnant women with and without treatment discontinuation in early pregnancy.
abstract: BACKGROUND
  In pregnant women taking antiretroviral treatment at conception treatment may be transiently stopped for safety concerns. Limited data are available on the consequences of such discontinuations.
  
  
  METHODS
  We used data from a national study to compare different treatment pathways during pregnancy. Overall, 321 women were evaluated and classified into three groups: women not on treatment at conception and who started treatment during pregnancy (starters; n=91); women on treatment at conception who temporarily discontinued treatment during first trimester (discontinuers; n=114); and women on treatment at conception who maintained treatment (continuers; n=116).
  
  
  RESULTS
  At conception, the three groups had similar CD4+ T-cell counts (499, 495 and 470 cells/mm3, respectively; P>0.10); starters had significantly higher median HIV RNA levels at conception (5,690 copies/ml) compared with both continuers (58 copies/ml, P<0.001) and discontinuers (49 copies/ml, P<0.001). Continuers maintained undetectable HIV RNA at all pregnancy trimesters, while discontinuers showed at first and second trimester transient negative effects on HIV (4,776 and 386 copies/ml, respectively) and CD4+ T-cell levels (376 and 392 cells/mm3, respectively), which were reversed at last trimester (52 copies/ml and 432 cells/mm3, respectively). No significant differences were observed among the groups in HIV RNA and CD4+ T-cell counts at third trimester, preterm delivery, low birth weight or mode of delivery. The number of cases of HIV transmission and birth defects were too limited to allow comparisons.
  
  
  CONCLUSIONS
  Early discontinuation of antiretroviral treatment in pregnancy produces transient virological and immunological effects without precluding the achievement of a good viral suppression at the end of pregnancy; no clinical consequences were observed.
authors.affiliation: Department of Infectious Diseases, Catholic University, Rome, Italy.
authors.forename: Enrica
authors.initials: E
authors.lastname: Tamburrini
authors.forename: Marina
authors.initials: M
authors.lastname: Ravizza
authors.forename: Marco
authors.initials: M
authors.lastname: Floridia
authors.forename: Cecilia
authors.initials: C
authors.lastname: Tibaldi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Alberico
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Anzidei
authors.forename: Anna
authors.initials: A
authors.lastname: Maccabruni
authors.forename: Alessandra
authors.initials: A
authors.lastname: Meloni
authors.forename: Anna Degli
authors.initials: AD
authors.lastname: Antoni
authors.forename: Fernanda
authors.initials: F
authors.lastname: Mori
authors.forename: Serena
authors.initials: S
authors.lastname: Dalzero
authors.forename: Valentina
authors.initials: V
authors.lastname: Conservan
authors.forename: Carmela
authors.initials: C
authors.lastname: Pinnetti
authors.forename: Enrico
authors.initials: E
authors.lastname: Ferrazzi
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D011261:Pregnancy Trimester, First; D012367:RNA, Viral / Q000097:blood; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors