Diabetes, sarcopenia, and frailty.
Frailty is a pre-disability condition. It now can be defined clinically. The major factors leading to frailty are sarcopenia and a decline in executive function. Stressors precipitate frail individuals into a state of disability. Diabetics develop the conditions necessary for frailty earlier than other aging individuals. Appropriate treatment of diabetes mellitus and frailty precursors can result in a slowing of the aging process.
Morley
John E
JE
Geriatric Research Education and Clinical Center, St. Louis VA Medical Center, 1 Jefferson Barracks Drive, 11E, St. Louis, MO 63125, USA. morley@slu.edu
D000368:Aged; D003071:Cognition / Q000502:physiology*; D048909:Diabetes Complications / Q000150:complications* / Q000523:psychology*; D016330:Frail Elderly; D006801:Humans; D009133:Muscular Atrophy / Q000150:complications* / Q000523:psychology*; D009752:Nutritional Status; D015431:Weight Loss