Familial melanoma.
Approximately 5% to 10% of cases of cutaneous melanoma occur in families that have a hereditary predisposition for this disease. In 20% to 40% of such melanoma families, germline mutations in the CDKN2A gene have been identified. Apart from a high risk of melanoma, a proportion of kindreds that have familial melanoma also have an increased risk of pancreatic carcinoma. Guidelines for management of familial melanoma and the issue of genetic testing for CDKN2A germline mutations are discussed.
Hansson
Johan
J
Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, Karolinska University Hospital Solna, S-17176 Stockholm, Sweden. johan.hansson@ki.se
D020022:Genetic Predisposition to Disease; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D010375:Pedigree; D012307:Risk Factors; D012878:Skin Neoplasms / Q000235:genetics*