[Influence of antenatal intermittent normobaric hypoxia during early organogenesis on the development of white rats].
The influence of antenatal intermittent normobaric hypoxia during early organogenesis (days 9-10 of intrauterine development) on the physical development, vegetative balance, and antioxidant defense system of 60-day-old rats was studied. Antenatal exposure to intermittent hypoxia resulted in the impaired physical development of all offspring during the early 15-day postnatal period and caused changes in the vegetative balance of heart regulation, which were differently directed in males and females. Moreover, females that survived antenatal hypoxia had a decreased superoxide dismutase activity in the brain, compared to that in the control rats.
Trofimova
L K
LK
Graf
A V
AV
Maslova
M V
MV
Dunaeva
T Iu
TIu
Krushinskaia
Ia V
IaV
Maklakova
A S
AS
Baĭzhumanov
A A
AA
Goncharenko
E N
EN
Sokolova
N A
NA
D000818:Animals; D000831:Animals, Newborn; D000975:Antioxidants / Q000378:metabolism; D001921:Brain / Q000196:embryology / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000196:embryology / Q000503:physiopathology*; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D038081:Organogenesis; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism / Q000503:physiopathology*; D051381:Rats; D012727:Sex Characteristics; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D013482:Superoxide Dismutase