A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris.
Psoriasis is a chronic inflammatory skin disease whose pathogenesis and genetic background remain unclear. Considering that previous studies have suggested an association of psoriasis vulgaris (PV) and killer cell immunoglobulin-like receptors (KIRs), we typed 15 KIR genes and human leukocyte antigen (HLA)-Cw in 79 Brazilian Caucasoid patients with PV and 110 healthy controls by polymerase chain reaction (PCR) using sequence-specific oligonucleotides and sequence-specific primers. We did not observe a relevant increase in the frequency of the activating KIR2DS1 gene in the PV group [KIR2DS1, 46 of 79 cases (58.2%) vs 40 of 110 controls (36.4%)]. However, an association of KIR2DS1 with Cw*0602+ in 26.5% of PV patients was observed, while it was present in only 5.4% of controls. These results suggest that activating KIR2DS1 gene may not confer susceptibility to PV, and an association of KIR2DS1 gene with the HLA-Cw*0602+ was observed in these patients.
Jobim
M
M
Department of Immunology, Hospital de Clínicas, Porto Alegre, Brazil. mjobim@hcpa.ufrgs.br
Jobim
L F J
LF
Salim
P H
PH
Cestari
T F
TF
Toresan
R
R
Gil
B C
BC
Jobim
M R
MR
Wilson
T J
TJ
Kruger
M
M
Schlottfeldt
J
J
Schwartsmann
G
G
D000483:Alleles; D001938:Brazil / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics*; D054340:Receptors, KIR / Q000235:genetics*
D015236:HLA-C Antigens; C491620:HLA-C*06:02 antigen; C496212:KIR2DS1 protein, human; D054340:Receptors, KIR