title: Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation.
abstract: Nectins and nectin-like molecules (Necls) are immunoglobulin-like transmembrane cell adhesion molecules that are expressed in various cell types. Homophilic and heterophilic engagements between family members provide cells with molecular tools for intercellular communications. Nectins primarily regulate cell-cell adhesions, whereas Necls are involved in a greater variety of cellular functions. Recent studies have revealed that nectins and NECL-5, in cooperation with integrin alphavbeta3 and platelet-derived growth factor receptor, are crucial for the mechanisms that underlie contact inhibition of cell movement and proliferation; this has important implications for the development and tissue regeneration of multicellular organisms and the phenotypes of cancer cells.
authors.affiliation: Department of Biochemistry and Molecular Biology, Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan. ytakai@med.kobe-u.ac.jp
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Takai
authors.forename: Jun
authors.initials: J
authors.lastname: Miyoshi
authors.forename: Wataru
authors.initials: W
authors.lastname: Ikeda
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Ogita
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D049109:Cell Proliferation; D003260:Contact Inhibition / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D000075983:Nectins; D011991:Receptors, Virus / Q000502:physiology
chemical_list: D015815:Cell Adhesion Molecules; D000075983:Nectins; D011991:Receptors, Virus; C066100:poliovirus receptor