Palladium-catalysed biscyclisation of allenic bromoalkenes through a zipper-mode cascade.
Treatment of allenic bromoalkenes bearing a nucleophilic moiety with a catalytic amount of palladium(0) in the presence of TBAF or Cs(2)CO(3) in MeCN affords bicyclic heterocycles in good to high yields, through zipper-mode cascade cyclisation.
Okano
Akinori
A
Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Mizutani
Tsuyoshi
T
Oishi
Shinya
S
Tanaka
Tetsuaki
T
Ohno
Hiroaki
H
Fujii
Nobutaka
N
D000475:Alkenes / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
D000475:Alkenes; D006846:Hydrocarbons, Halogenated; D010165:Palladium; D002244:Carbon; D010100:Oxygen