Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar.
The CHCl(3)-soluble fraction of 70% EtOH extract of the flower of Kayea assamica completely killed human pancreatic PANC-1 cancer cells preferentially under nutrient-deprived conditions at 1 microg/mL. Bioassay-guided fractionation and isolation afforded two novel compounds, kayeassamins A (1) and B (2). Their structures were elucidated using extensive spectroscopic methods and the modified Mosher method. Each compound showed 100% preferential cytotoxicity (PC(100)) against PANC-1 cells under nutrient-deprived conditions at 1 microM. Furthermore, both compounds inhibited the migration of PANC-1 cells in the wound closure assay.
Win
Nwet Nwet
NN
Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan.
Awale
Suresh
S
Esumi
Hiroyasu
H
Tezuka
Yasuhiro
Y
Kadota
Shigetoshi
S
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D028084:Clusiaceae / Q000378:metabolism*; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D035264:Flowers / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D039821:Monoterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D002052:Myanmar; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D039821:Monoterpenes; D010936:Plant Extracts; C533042:kayeassamin A; C533043:kayeassamin B