title: Coupling reactions of bromoalkynes with imidazoles mediated by copper salts: synthesis of novel N-alkynylimidazoles.
abstract: A cross-coupling reaction of imidazoles with bromoalkynes in the presence of a catalytic amount of CuI is reported. This protocol allows an access to novel N-(1-alkynyl)imidazoles in moderate to good yields.
authors.affiliation: Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: Christophe
authors.initials: C
authors.lastname: Laroche
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Freyer
authors.forename: Sean M
authors.initials: SM
authors.lastname: Kerwin
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D006842:Hydrocarbons, Brominated / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D007454:Iodides / Q000737:chemistry
chemical_list: D000480:Alkynes; D006842:Hydrocarbons, Brominated; D007093:Imidazoles; D007454:Iodides; D003300:Copper