title: Sequence-dependent effects on the properties of semiflexible biopolymers.
abstract: Using a path integral technique, we show exactly that for a semiflexible biopolymer in constant extension ensemble, no matter how long the polymer and how large the external force, the effects of short-range correlations in the sequence-dependent spontaneous curvatures and torsions can be incorporated into a model with well-defined mean spontaneous curvature and torsion as well as a renormalized persistence length. Moreover, for a long biopolymer with large mean persistence length, the sequence-dependent persistence lengths can be replaced by their mean. However, for a short biopolymer or for a biopolymer with small persistence lengths, inhomogeneity in persistence lengths tends to make physical observables very sensitive to details and therefore less predictable.
authors.affiliation: Department of Physics and Graduate Institute of Life Sciences, Tamkang University, 151 Ying-chuan, Tamsui, Taiwan, Republic of China. zzhou@mail.tku.edu.tw
authors.forename: Zicong
authors.initials: Z
authors.lastname: Zhou
authors.forename: Béla
authors.initials: B
authors.lastname: Joós
mesh_terms: D000465:Algorithms; D001483:Base Sequence; D001703:Biophysics / Q000379:methods*; D001704:Biopolymers / Q000737:chemistry*; D003198:Computer Simulation; D015233:Models, Statistical; D008968:Molecular Conformation; D016011:Normal Distribution; D009991:Oscillometry; D011108:Polymers / Q000737:chemistry; D011789:Quantum Theory; D013696:Temperature
chemical_list: D001704:Biopolymers; D011108:Polymers