[The effect of long-term external ionizing radiation on the functional activity of rat thyroid under enhanced potassium iodide consumption].
The study was devoted to the effect of long-term (20 days) external ionizing radiation at a dose of 0.5 Gy on the iodide metabolism in the rat thyroid under supplementation of high iodine doses (10 daily KI doses). It was found that the potassium iodide administration partially prevented the effects of a post radiation decrease of serum thyroid hormone levels (the level of T4 was normal and that of T3 was 77.4% of the controls). After the supplementation of 10 daily iodide doses, the rat thyroid tissue showed the most pronounced increase in the levels of total, free and protein-bound iodide compared to the groups of animals consuming normal and elevated KI doses. Pronounced inhibition of thyroid peroxidase activity (3.1-fold) was noted in the same group. The data obtained indicate a radiation-induced activation of iodide uptake during its enhanced supplementation and disturbed iodide enzymatic oxidation and organification.
Lupachik
S V
SV
Nadol'nik
L I
LI
D000818:Animals; D004334:Drug Administration Schedule; D005260:Female; D007453:Iodide Peroxidase / Q000378:metabolism; D007454:Iodides / Q000378:metabolism; D011193:Potassium Iodide / Q000008:administration & dosage / Q000494:pharmacology*; D011839:Radiation, Ionizing; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D013963:Thyroid Hormones / Q000378:metabolism*; D013997:Time Factors
D007454:Iodides; D013963:Thyroid Hormones; D011193:Potassium Iodide; D007453:Iodide Peroxidase