Propargylation of 1,3-dicarbonyl compounds with 1,3-diarylpropynes via oxidative cross-coupling between sp3 C-H and sp3 C-H.
A highly efficient oxidative-coupling reaction between diarylpropargylic sp(3) C-H and active methylenic sp(3) C-H was achieved with DDQ as oxidant. The reaction afforded a direct method for the propargylation of 1,3-dicarbonyl compounds, thus providing a concise synthesis of the corresponding products.
Cheng
Dongping
D
Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou 310028, People's Republic of China.
Bao
Weiliang
W
D000480:Alkynes / Q000737:chemistry*; D016227:Benzoquinones / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006844:Hydrocarbons, Cyclic / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008956:Models, Chemical; D016877:Oxidants / Q000737:chemistry; D020005:Propanols / Q000737:chemistry*
D000480:Alkynes; D016227:Benzoquinones; D003432:Cross-Linking Reagents; D006844:Hydrocarbons, Cyclic; D007659:Ketones; D016877:Oxidants; D020005:Propanols; C000928:dichlorodicyanobenzoquinone; D002244:Carbon; D006859:Hydrogen; C028255:propargyl alcohol