Rhabdomyolysis with atorvastatin and fusidic acid.
Rhabdomyolysis is a rare but life-threatening complication of statin therapy. A 74-year-old man, treated with atorvastatin, developed rhabdomyolysis after the co-administration of fusidic acid and flucloxacillin. The patient recovered with supportive treatment and subsequently tolerated reintroduction of atorvastatin. Pharmacokinetic interactions can cause raised plasma statin concentrations, which can precipitate rhabdomyolysis in the presence of certain predisposing biological factors.
O'Mahony
C
C
The Heart Hospital, 16-18 Westmoreland Street, London W1G 8PH, UK. c.omahony@doctors.org.uk
Campbell
V L
VL
Al-Khayatt
M S
MS
Brull
D J
DJ
D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000069059:Atorvastatin; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005436:Floxacillin / Q000009:adverse effects; D005672:Fusidic Acid / Q000009:adverse effects*; D006331:Heart Diseases / Q000188:drug therapy; D006538:Heptanoic Acids / Q000009:adverse effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy; D011758:Pyrroles / Q000009:adverse effects*; D012206:Rhabdomyolysis / Q000139:chemically induced*
D000900:Anti-Bacterial Agents; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D005436:Floxacillin; D005672:Fusidic Acid; D000069059:Atorvastatin