title: The effects of desflurane and propofol-remifentanil on postoperative hepatic and renal functions after right hepatectomy in liver donors.
abstract: Various volatile anesthetics have been used in hepatectomy in living donors, and their effects on major organs have been extensively evaluated. However, the impact of total intravenous anesthesia (TIVA) on postoperative liver and renal functions after large liver resections has been less extensively investigated than that of volatile agents. The aim of this study was to compare the postoperative hepatic and renal functions between volatile anesthesia with desflurane and TIVA with propofol-remifentanil in living donors undergoing right hepatectomy. Seventy adult patients were randomly allocated into 2 groups: the desflurane group (n = 35) and TIVA group (n = 35). Aspartate aminotransferase, alanine aminotransferase, prothrombin time (PT), albumin, total bilirubin (TB), blood urea nitrogen (BUN), creatinine (Cr), BUN/Cr ratio, estimated glomerular filtration rate (GFR), platelet count, and hemoglobin levels were analyzed in the preoperative period, immediately after the operation, and on the first, second, third, fifth, seventh, and thirtieth postoperative days (PODs). Most of the liver function test results were not significantly different between the 2 groups. However, PT (international normalized ratio) and TB were significantly greater on POD 5 in the TIVA group. Among the renal function tests, Cr was significantly higher and estimated GFR was significantly lower on POD 1 in the TIVA group. The platelet counts and hemoglobin levels were similar between the 2 groups. In conclusion, the results of our study suggest that living related donors for liver transplant may have a better outcome following anesthesia with desflurane. However, further testing will be necessary to prove this hypothesis.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Justin Sang
authors.initials: JS
authors.lastname: Ko
authors.forename: Mi Sook
authors.initials: MS
authors.lastname: Gwak
authors.forename: Soo Joo
authors.initials: SJ
authors.lastname: Choi
authors.forename: Gaab Soo
authors.initials: GS
authors.lastname: Kim
authors.forename: Jie Ae
authors.initials: JA
authors.lastname: Kim
authors.forename: Mikyung
authors.initials: M
authors.lastname: Yang
authors.forename: Sangmin Maria
authors.initials: SM
authors.lastname: Lee
authors.forename: Hyun Sung
authors.initials: HS
authors.lastname: Cho
authors.forename: In Sun
authors.initials: IS
authors.lastname: Chung
authors.forename: Myung Hee
authors.initials: MH
authors.lastname: Kim
mesh_terms: D000328:Adult; D000777:Anesthetics / Q000008:administration & dosage* / Q000009:adverse effects; D018685:Anesthetics, Inhalation / Q000009:adverse effects; D018686:Anesthetics, Intravenous / Q000009:adverse effects; D000077335:Desflurane; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects / Q000031:analogs & derivatives; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008099:Liver / Q000187:drug effects*; D008111:Liver Function Tests; D019520:Living Donors; D008297:Male; D010880:Piperidines / Q000009:adverse effects; D015742:Propofol / Q000009:adverse effects; D000077208:Remifentanil
chemical_list: D000777:Anesthetics; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077335:Desflurane; D007530:Isoflurane; D000077208:Remifentanil; D015742:Propofol