A prospective study of 728 cases of non-Hodgkin lymphoma from a single laboratory in Shanghai, China.
The frequency of subtypes of lymphoid neoplasms was determined in a prospective series of 831 patients presenting at 29 Shanghai hospitals over a 4-year period. Diagnosis and classification was established in a single laboratory according to the 2001 WHO classification system. The frequency of non-Hodgkin lymphoma was 87.6% (n = 728) and Hodgkin lymphoma was 12.4% (n = 103). The most prevalent NHL subtypes diagnosed using WHO criteria were diffuse large B cell lymphoma (DLBCL), precursor B lymphoblastic leukemia/lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Although a low incidence has been reported in some Asian populations, CLL/SLL was commonly encountered, indicating that chronic lymphoid neoplasms are not rare in Shanghai. Consistent with previous reports, our findings indicate a decrease in the frequency of follicular lymphoma and an increase in T cell neoplasms compared to the West. Precursor T lymphoblastic leukemia/lymphoma, anaplastic large T cell lymphoma, aggressive NK cell leukemia, angioimmunoblastic T cell lymphoma and peripheral T cell lymphoma were prominent subtypes of T cell NHL.
Gross
Sherilyn A
SA
Fudan-Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, 130 Dong An Road, 200032, Shanghai, China.|Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado Denver, Denver, CO, USA.
Zhu
Xiongzeng
X
Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China.
Bao
Liming
L
Fudan-Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, 130 Dong An Road, 200032, Shanghai, China.|Division of Human Genetics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ryder
John
J
Department of Pathology, School of Medicine, University of Colorado Denver, Denver, CO, USA.
Le
Anh
A
Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado Denver, Denver, CO, USA.
Chen
Yan
Y
Fudan-Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, 130 Dong An Road, 200032, Shanghai, China.
Wang
Xiao Qin
XQ
Fudan-Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, 130 Dong An Road, 200032, Shanghai, China.
Irons
Richard D
RD
Fudan-Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, 130 Dong An Road, 200032, Shanghai, China. richard.irons@cinpathogen.com.|Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado Denver, Denver, CO, USA. richard.irons@cinpathogen.com.|Department of Pathology, School of Medicine, University of Colorado Denver, Denver, CO, USA. richard.irons@cinpathogen.com.|Cinpathogen, Inc., Boulder, CO, USA. richard.irons@cinpathogen.com.|Cinpathogen, Inc., Shanghai, China. richard.irons@cinpathogen.com.
D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data*; D002681:China / Q000453:epidemiology; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008228:Lymphoma, Non-Hodgkin / Q000145:classification* / Q000208:ethnology* / Q000235:genetics; D015995:Prevalence; D011446:Prospective Studies; D014505:Urban Population / Q000706:statistics & numerical data; D014944:World Health Organization
D004273:DNA, Neoplasm