title: The effects of systemic alendronate with or without intraalveolar collagen sponges on postextractive bone resorption: a single masked randomized clinical trial.
abstract: Alendronate is a bisphosphonate frequently used to reduce bone resorption. It has been used for osteoporosis, Paget's disease, and also as adjunctive therapy for periodontal disease. The aim of this study was to evaluate the effect of systemic alendronate with or without endoalveolar collagen sponge on vertical bone resorption after lower wisdom tooth extraction. Forty patients referred for wisdom tooth impaction were selected. Before surgery, patients were randomly assigned to receive one of the following pharmacologic treatments: no medication (group 1), postextractive endoalveolar collagen sponge (group 2), systemic alendronate for 4 months starting the day of surgery (group 3), and group 2 + group 3 (group 4). Standardized orthopantomographic evaluation was obtained during recruitment (T1), immediately after surgery (T2), and 4 months (T3) to evaluate crestal and alveolar socket changes. Results indicate that at T2, crest and socket level did not show significant differences between the four groups. At T3, test sites treated showed less bone resorption compared with controls. In particular, higher vertical bone height levels and a faster intraalveolar healing were achieved in groups 3 and 4. Systemically given alendronate may be used successfully to reduce vertical bone resorption after wisdom tooth extraction.
authors.affiliation: Department of Surgery, Section of Oral Surgery, University of Pisa, Pisa, Italy. f.graziani@med.unipi.it
authors.forename: Filippo
authors.initials: F
authors.lastname: Graziani
authors.forename: Stefano
authors.initials: S
authors.lastname: Rosini
authors.forename: Silvia
authors.initials: S
authors.lastname: Cei
authors.forename: Fabio
authors.initials: F
authors.lastname: La Ferla
authors.forename: Mario
authors.initials: M
authors.lastname: Gabriele
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D019386:Alendronate / Q000627:therapeutic use*; D016301:Alveolar Bone Loss / Q000209:etiology / Q000517:prevention & control*; D000539:Alveolar Process / Q000187:drug effects / Q000601:surgery; D001672:Biocompatible Materials / Q000494:pharmacology; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects; D001862:Bone Resorption / Q000517:prevention & control*; D003094:Collagen / Q000494:pharmacology; D005260:Female; D048091:Guided Tissue Regeneration / Q000379:methods; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D012016:Reference Values; D016037:Single-Blind Method; D015503:Surgical Sponges; D014081:Tooth Extraction / Q000009:adverse effects; D020390:Tooth Socket / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D050071:Bone Density Conservation Agents; D003094:Collagen; D019386:Alendronate