title: Age-related muscle dysfunction.
abstract: Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to highlight cellular, molecular, and biochemical changes that contribute to age-related muscle dysfunction.
authors.affiliation: Department of Physical Medicine and Rehabilitation, University of Minnesota, MMC 388, 420 Delaware Street, S.E., Minneapolis, MN 55455, USA. thomp067@umn.edu
authors.forename: LaDora V
authors.initials: LV
authors.lastname: Thompson
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000378:metabolism*; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000503:physiopathology*; D009133:Muscular Atrophy / Q000378:metabolism / Q000503:physiopathology*; D018384:Oxidative Stress; D011499:Protein Processing, Post-Translational
chemical_list: D009124:Muscle Proteins