[Mexidol effects in extreme conditions (experiments with animals)].
In extreme conditions like a new situation, bright light, open space, immobilization, height (the open field and lifted cruciform labyrinth test) and a conflict between an unavoidable action and fear of painful mexidol at the doses of 50 and 100 mg/kg of a body weight eliminates anxiety and fear in rats, recovers adequate reactions and the orientative-trying behavior, and lessens aggressiveness. Mexidol extends life span of mice in acute hypoxic conditions. Mexidol is highly competitive with diazepam as an anti-stress agent and excels it as an anti-hypoxic agent; in contrast to diazepam, mexidol does not cause sedation and myorelaxation. Based on these findings, mexidol can be prescribed to humans to maintain efficiency in all kinds of extreme situations.
Voronina
T A
TA
Iasnetsov
V V
VV
Smirnov
L D
LD
Molodavkin
G M
GM
Iasnetsov
V V
VV
Larentsova
L I
LI
Shashkov
V S
VS
D000818:Animals; D001007:Anxiety / Q000188:drug therapy* / Q000209:etiology; D005106:Exploratory Behavior / Q000187:drug effects; D051379:Mice; D010847:Picolines / Q000008:administration & dosage / Q000627:therapeutic use*; D011589:Psychology, Experimental / Q000379:methods; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013315:Stress, Psychological / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D016896:Treatment Outcome
D010847:Picolines; D011619:Psychotropic Drugs; C070020:emoxypine succinate