title: Biological activity of amide derivatives of lysine.
abstract: Five substituted amides of lysine with the general formula: X-Lys-NH-Y, where X= acetyl or ethoxycarbonyl, Y= cyclohexyl, benzyl, hexyl or cadaverine residue were synthesised and their effects on fibrinolytic activity of plasmin, clotting activity of thrombin and amidolytic activities of both enzymes were examined.
authors.affiliation: Department of Organic Chemistry, Medical University of Białystok, Białystok, Poland. kmidura@amb.edu.pl
authors.forename: Krystyna
authors.initials: K
authors.lastname: Midura-Nowaczek
authors.forename: Izabela
authors.initials: I
authors.lastname: Lepietuszko
authors.forename: Irena
authors.initials: I
authors.lastname: Bruzgo
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Markowska
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D005342:Fibrinolysis / Q000187:drug effects / Q000502:physiology; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors*
chemical_list: D000577:Amides; D013917:Thrombin; D005341:Fibrinolysin; D008239:Lysine