Structure-activity relationship studies of the chromosome segregation inhibitor, Incentrom A.
A series of Incentrom A analogs that inhibit the chromosome segregation process in yeast were synthesized and tested for their effects on chromosome stability and cell proliferation. Pharmacophore and structure-activity relationship of Incentrom A for the anti-yeast activity were established.
Lee
Hee-Yoon
HY
Department of Chemistry and School of Molecular Science (BK21), KAIST, Daejeon 305-701, Republic of Korea. leeheeyoon@kaist.ac.kr
Jung
Yongsik
Y
Kim
Wonyeob
W
Kim
Jin Hee
JH
Suh
Min-Soo
MS
Shin
Seung Koo
SK
Yoon
Hye-Joo
HJ
D000935:Antifungal Agents / Q000494:pharmacology; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D043171:Chromosomal Instability; D020090:Chromosome Segregation / Q000187:drug effects*; D015195:Drug Design; D008938:Mitosis; D008956:Models, Chemical; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D002227:Carbazoles; D010879:Piperazines; C533041:incentrom A