Inhibition of LFA-1 mediated T-cell motility by naphthoquinones.
An in vitro T-cell migration assay has been established that can be used to study the effects of compounds on the development of T-cell polarisation with HuT-78 T lymphocytes. This assay indicates the ability of compounds tested to inhibit the inflammatory response by decreasing LFA-1-mediated T-cell motility. The effect of a series of naturally occurring quinone isolates on motility has been evaluated in this assay. Distinct differences have been observed between naphthoquinones, dihydrofuranonaphthoquinones and anthraquinones.
Sheridan
Helen
H
Trinity College Dublin, School of Pharmacy & Pharmaceutical Sciences, Panoz Institute, Dublin, Ireland. hsheridn@tcd.ie
Hook
Ingrid
I
Nestor
Cora
C
Coppins
Jennifer
J
Ehrhardt
Carsten
C
Frankish
Neil
N
D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects*; D006801:Humans; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism*; D009285:Naphthoquinones / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism
D016169:Lymphocyte Function-Associated Antigen-1; D009285:Naphthoquinones