title: A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris.
abstract: Psoriasis is a chronic inflammatory skin disease whose pathogenesis and genetic background remain unclear. Considering that previous studies have suggested an association of psoriasis vulgaris (PV) and killer cell immunoglobulin-like receptors (KIRs), we typed 15 KIR genes and human leukocyte antigen (HLA)-Cw in 79 Brazilian Caucasoid patients with PV and 110 healthy controls by polymerase chain reaction (PCR) using sequence-specific oligonucleotides and sequence-specific primers. We did not observe a relevant increase in the frequency of the activating KIR2DS1 gene in the PV group [KIR2DS1, 46 of 79 cases (58.2%) vs 40 of 110 controls (36.4%)]. However, an association of KIR2DS1 with Cw*0602+ in 26.5% of PV patients was observed, while it was present in only 5.4% of controls. These results suggest that activating KIR2DS1 gene may not confer susceptibility to PV, and an association of KIR2DS1 gene with the HLA-Cw*0602+ was observed in these patients.
authors.affiliation: Department of Immunology, Hospital de Clínicas, Porto Alegre, Brazil. mjobim@hcpa.ufrgs.br
authors.forename: M
authors.initials: M
authors.lastname: Jobim
authors.forename: L F J
authors.initials: LF
authors.lastname: Jobim
authors.forename: P H
authors.initials: PH
authors.lastname: Salim
authors.forename: T F
authors.initials: TF
authors.lastname: Cestari
authors.forename: R
authors.initials: R
authors.lastname: Toresan
authors.forename: B C
authors.initials: BC
authors.lastname: Gil
authors.forename: M R
authors.initials: MR
authors.lastname: Jobim
authors.forename: T J
authors.initials: TJ
authors.lastname: Wilson
authors.forename: M
authors.initials: M
authors.lastname: Kruger
authors.forename: J
authors.initials: J
authors.lastname: Schlottfeldt
authors.forename: G
authors.initials: G
authors.lastname: Schwartsmann
mesh_terms: D000483:Alleles; D001938:Brazil / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics*; D054340:Receptors, KIR / Q000235:genetics*
chemical_list: D015236:HLA-C Antigens; C491620:HLA-C*06:02 antigen; C496212:KIR2DS1 protein, human; D054340:Receptors, KIR