title: Whole-body skeletal muscle mass is not related to glucose tolerance or insulin sensitivity in overweight and obese men and women.
abstract: The relationship between skeletal muscle mass, visceral adipose tissue, insulin sensitivity, and glucose tolerance was examined in 214 overweight or obese, but otherwise healthy, men (n = 98) and women (n = 116) who participated in various exercise and (or) weight-loss intervention studies. Subjects had a 75 g oral glucose tolerance test and (or) insulin sensitivity measures by a 3 h hyperinsulinemic-euglycemic clamp technique. Whole-body skeletal muscle mass and visceral adipose tissue were measured using a multi-slice magnetic resonance imaging protocol. Total body skeletal muscle mass was not associated with any measure of glucose metabolism in men or women (p > 0.10). These observations remained independent of age and total adiposity. Conversely, visceral adipose tissue was a significant predictor of various measures of glucose metabolism in both men and women with or without control for age and (or) total body fat (p < 0.05). Although skeletal muscle is a primary site for glucose uptake and deposition, these findings suggest that unlike visceral adipose tissue, whole-body skeletal muscle mass per se is not associated with either glucose tolerance or insulin sensitivity in overweight and obese men and women.
authors.affiliation: School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Kuk
authors.forename: Katherine
authors.initials: K
authors.lastname: Kilpatrick
authors.forename: Lance E
authors.initials: LE
authors.lastname: Davidson
authors.forename: Robert
authors.initials: R
authors.lastname: Hudson
authors.forename: Robert
authors.initials: R
authors.lastname: Ross
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D017677:Age Distribution; D000368:Aged; D005081:Exercise Therapy; D005260:Female; D005947:Glucose / Q000378:metabolism; D015309:Glucose Clamp Technique / Q000706:statistics & numerical data; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test / Q000706:statistics & numerical data; D006801:Humans; D007333:Insulin Resistance; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology*; D009765:Obesity / Q000097:blood / Q000473:pathology / Q000628:therapy; D050177:Overweight / Q000097:blood* / Q000473:pathology* / Q000628:therapy; D011237:Predictive Value of Tests; D017678:Sex Distribution; D055815:Young Adult
chemical_list: D005947:Glucose