Total Mini-Mental State Examination score and regional cerebral blood flow using Z score imaging and automated ROI analysis software in subjects with memory impairment.
OBJECTIVE
The Mini-Mental State Examination (MMSE) is considered a useful supplementary method to diagnose dementia and evaluate the severity of cognitive disturbance. However, the region of the cerebrum that correlates with the MMSE score is not clear. Recently, a new method was developed to analyze regional cerebral blood flow (rCBF) using a Z score imaging system (eZIS). This system shows changes of rCBF when compared with a normal database. In addition, a three-dimensional stereotaxic region of interest (ROI) template (3DSRT), fully automated ROI analysis software was developed. The objective of this study was to investigate the correlation between rCBF changes and total MMSE score using these new methods.


METHODS
The association between total MMSE score and rCBF changes was investigated in 24 patients (mean age +/- SD 71.5 +/- 9.2 years; 6 men and 18 women) with memory impairment using eZIS and 3DSRT. Step-wise multiple regression analysis was used for multivariate analysis, with the total MMSE score as the dependent variable and rCBF change in 24 areas as the independent variable.


RESULTS
Total MMSE score was significantly correlated only with the reduction of left hippocampal perfusion but not with right (P < 0.01).


CONCLUSIONS
Total MMSE score is an important indicator of left hippocampal function.
Ikeda
Eiji
E
Department of Neurobiology and Behavior, Unit of Basic Medical Sciences, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Shiozaki
Kazumasa
K
Takahashi
Nobukazu
N
Togo
Takashi
T
Odawara
Toshinari
T
Oka
Takashi
T
Inoue
Tomio
T
Hirayasu
Yoshio
Y
D000368:Aged; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging*; D010054:Brief Psychiatric Rating Scale; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis*; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software