Effect of strontium in combination with fluoride on enamel remineralization in vitro.
Previous studies showed that strontium (Sr) as well as fluoride (F) can enhance enamel remineralization. The aim of this study was to evaluate the effects of Sr in combination with F on enamel remineralization in vitro. Sixty enamel specimens obtained from caries free human premolars were demineralised to produce caries-like lesions. Half of each lesion was covered with nail varnish as an untreated control. The specimens were then randomly divided into F and Sr+F treatment groups. The F group was exposed to remineralizing solutions (1.5mM CaCl(2), 0.9 mM KH(2)PO(4)) containing 1 ppm, 0.1 ppm or 0.05 ppm F. The Sr+F treatment group was exposed to the same solutions including 10 ppm Sr. After 2 weeks, lesion depth, mineral loss and percentage enamel remineralization were determined using transversal microradiography. There was a significant decrease in mineral loss in all groups (p<0.001). Lesion depth was significantly reduced for all groups (p<0.05) with the exception of group F. Remineralization was significantly affected by F concentration (p=0.000). The participation of Sr resulted in a significant enhancement of remineralization (p<0.001) with a synergistic effect of the Sr+F combination (p<0.01). It was concluded that while the remineralizing process was affected by the concentration of F, there was also an interaction between F and Sr when they were used in conjunction.
Thuy
Tran Thu
TT
Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi-Gakuin University, Japan. tranthuthuyrhm@yahoo.com
Nakagaki
Haruo
H
Kato
Kazuo
K
Hung
Phan Ai
PA
Inukai
Junko
J
Tsuboi
Shinji
S
Nakagaki
Hidetaka
H
Hirose
Mina N
MN
Igarashi
Seiji
S
Robinson
Colin
C
D001641:Bicuspid / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D003743:Dental Enamel / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D005460:Fluorides, Topical / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008852:Microradiography; D008903:Minerals / Q000378:metabolism; D013324:Strontium / Q000494:pharmacology*; D017001:Tooth Demineralization / Q000378:metabolism / Q000473:pathology; D014089:Tooth Remineralization / Q000379:methods*
D005460:Fluorides, Topical; D008903:Minerals; D013324:Strontium