title: Plasticity in the adult brain: lessons from the visual system.
abstract: While cortical circuits display maximal sensitivity to sensory experience during critical periods of early postnatal development, far less plasticity is present in the mature brain. Ocular dominance shift of visual cortical neurons in response to eye occlusion and recovery of visual functions from a period of sensory deprivation are two classical models in the study of critical period determinants in the visual cortex. Recent papers employing various pharmacological and environmental strategies have shown that it is possible to reinstate much greater levels of plasticity in the adult visual cortex than previously suspected. These studies point toward intracortical inhibition as a crucial determinant for critical period regulation in the visual system and have a great potential for therapeutic rehabilitation and recovery from injury in the adult brain.
authors.affiliation: Laboratory of Neurobiology, Scuola Normale Superiore, Via Moruzzi 1, 56100, Pisa, Italy. m.spolidoro@sns.it
authors.forename: Maria
authors.initials: M
authors.lastname: Spolidoro
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sale
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Berardi
authors.forename: Lamberto
authors.initials: L
authors.lastname: Maffei
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D023882:Dominance, Ocular / Q000502:physiology; D006801:Humans; D009433:Neural Inhibition / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D012683:Sensory Deprivation / Q000502:physiology; D013997:Time Factors; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology*; D014795:Visual Pathways / Q000166:cytology / Q000502:physiology*