Identification and analysis of drugs in the solid state by 13C CPMAS NMR: suxamethonium chloride and hydrocortisonum (Corhydron).
Cross-polarization (CP) magic angle spinning (MAS) 13C NMR spectroscopy has become a routine tool in pharmacy, employed to identify and characterize drugs in the solid phase. 13C CPMAS NMR spectra were recorded for solid hydrocortisone 21-hemisuccinate and suxamethonium chloride. White crystalline substances, such as these two drugs, can be easily distinguished; and solid-state 13NMR spectra of remarkably good quality are obtained in less than half an hour. 13C CPMAS chemical shifts for solid suxamethonium chloride and hydrocortisone sodium hemisuccinate are given, as well as cross-polarization kinetic parameters for suxamethonium chloride.
Paradowska
Katarzyna
K
Department of Physical Chemistry, Medical University of Warsaw, Warsaw, Poland.
Wolniak
Michał
M
Fijałek
Zbigniew
Z
Wawer
Iwona
I
D000893:Anti-Inflammatory Agents / Q000032:analysis; D002247:Carbon Isotopes; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009467:Neuromuscular Depolarizing Agents / Q000032:analysis; D013390:Succinylcholine / Q000032:analysis*
D000893:Anti-Inflammatory Agents; D002247:Carbon Isotopes; D009467:Neuromuscular Depolarizing Agents; D013390:Succinylcholine; C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone