title: Persistence with teriparatide in postmenopausal osteoporosis; impact of a patient education and follow-up program: the French experience.
abstract: CONCLUSIONS
  This study evaluated the 18-month persistence with teriparatide in 5413 postmenopausal osteoporotic women who were enrolled in an education and follow-up program. Analysis showed that the persistence rate was 81.5% for women who follow the program, higher than for existing oral antiresorptive treatments.
  
  
  BACKGROUND
  An education and follow-up program was developed after launch of teriparatide in France in September 2004, to help women to follow the treatment. The objective of this study was to evaluate the persistence with teriparatide in postmenopausal osteoporotic women following this program.
  
  
  METHODS
  Data about persistence are available for the period September 2004 to June 2007. Persistence is defined as the percentage of patients still on treatment at the end of the 18-month course, and it has been compared to the data provided by the French universal health insurance system.
  
  
  RESULTS
  Since the launch of teriparatide in France in September 2004, 5413 postmenopausal women (mean age 72.3 +/- 14.5 years) with osteoporosis and vertebral fractures (mean 3.9 +/- 2) have participated in the program. The persistence rate at 15 months was 81.5%, and our analysis suggested that a majority of patients completed the 18-month treatment course. The main reason for discontinuation was adverse events (46.7%). Data of the French Universal Health Insurance suggest that the persistence may be close to 0% for women who are not in the program.
  
  
  CONCLUSIONS
  Postmenopausal osteoporotic women treated by teriparatide and enrolled in an education and follow-up program have a high persistence rate.
authors.affiliation: Paris Descartes University, Rheumatology Department Cochin Hospital, Paris, France. karine.briot@cch.aphp.fr
authors.forename: K
authors.initials: K
authors.lastname: Briot
authors.forename: P
authors.initials: P
authors.lastname: Ravaud
authors.forename: P
authors.initials: P
authors.lastname: Dargent-Molina
authors.forename: M
authors.initials: M
authors.lastname: Zylberman
authors.forename: S
authors.initials: S
authors.lastname: Liu-Leage
authors.forename: C
authors.initials: C
authors.lastname: Roux
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050071:Bone Density Conservation Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004812:Epidemiologic Methods; D005260:Female; D005602:France; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000188:drug therapy*; D010349:Patient Compliance / Q000706:statistics & numerical data*; D010353:Patient Education as Topic / Q000379:methods*; D015397:Program Evaluation; D016103:Spinal Fractures / Q000209:etiology / Q000517:prevention & control; D019379:Teriparatide / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D050071:Bone Density Conservation Agents; D019379:Teriparatide