title: Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model.
abstract: OBJECTIVE
  To determine whether rosiglitazone-enriched diet offer protection in a classical model of liver ischemia-reperfusion injury in rats.
  
  
  METHODS
  Two days before the experiment, rats were divided into 2 groups: Control Group (n=13) rats fed with standard diet; Rosi Group (n=13): rats fed with a powdered standard diet supplemented with rosiglitazone. The animals were submitted to liver ischemia-reperfusion by clamping the pedicle of median and left anterolateral lobes. After 1 hour of partial hepatic ischemia, the clamp was removed for reperfusion. After 2 or 24 hours (Control and Rosi Groups), blood was collected for enzymes and cytokines analysis. Ischemic and non-ischemic liver were collected for malondialdehyde analysis and histological assessment. Lungs were removed for tissue myeloperoxidase quantification.
  
  
  RESULTS
  There were no statistical differences between groups for all analysed parameters.
  
  
  CONCLUSIONS
  In this model, rosiglitazone-enriched diet did not protect liver against ischemia-reperfusion injury.
authors.affiliation: Transplantation Division, Department of Gastroenterology, School of Medicine, USP, São Paulo, Brazil. drrteixeira@uol.com.br
authors.forename: Antonio Roberto Franchi
authors.initials: AR
authors.lastname: Teixeira
authors.forename: Nilza Trindade
authors.initials: NT
authors.lastname: Molan
authors.forename: Marta
authors.initials: M
authors.lastname: Bellodi-Privato
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Coelho
authors.forename: Kátia Ramos
authors.initials: KR
authors.lastname: Leite
authors.forename: Antônio Carlos
authors.initials: AC
authors.lastname: Seguro
authors.forename: Telésforo
authors.initials: T
authors.lastname: Bacchella
authors.forename: Marcel Cerqueira César
authors.initials: MC
authors.lastname: Machado
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D016207:Cytokines / Q000097:blood; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000201:enzymology; D008297:Male; D047495:PPAR gamma / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology / Q000517:prevention & control*; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000008:administration & dosage*
chemical_list: D016207:Cytokines; D047495:PPAR gamma; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D001219:Aspartate Aminotransferases