[Vaccines for precancer and cancer of the uterine cervix. II. Therapeutic HPV vaccines].
Vaccines are one of the most powerful immunomodulators and represent perspective direction in the modern strategy of treatment of cancer. Among the gynecological malignancies cervical cancer is the most perspective localization for the implementation of specific therapeutic vaccine, by reason of clear viral ethiopathogenesis and important medical and social effect of the disease. Nowadays, the therapeutic HPV vaccines under research, for precancer and cancer of uterine cervix aimed to eliminate the persistent viral infection. In the review, the results of several clinical trials concerning the effect of HPV vaccines, created on the basis of viral peptides, viral like particles, DNA and viral vectors have been discussed.
Kostova
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Gynecology Clinic, National Hospital of Oncology-Sofia.
Zlatkov
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D019496:Cancer Vaccines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D053918:Papillomavirus Vaccines / Q000627:therapeutic use*; D011230:Precancerous Conditions / Q000517:prevention & control* / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control* / Q000821:virology
D019496:Cancer Vaccines; D053918:Papillomavirus Vaccines