Structure-activity relationship studies of permeability modulating peptide AT-1002.
AT-1002 a 6-mer synthetic peptide belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. The aim of this project was to elaborate on the structure-activity relationship of this peptide with the specific goal to replace the P2 cysteine amino acid. Herein, we report the discovery of peptides that exhibit reversible permeability enhancement properties with an increased stability profile.
Li
Min
M
Alba Therapeutics Corporation, 800 West Baltimore Street, Suite 400, Baltimore, MD 21201, USA.
Oliver
Ed
E
Kitchens
Kelly M
KM
Vere
John
J
Alkan
Sefik S
SS
Tamiz
Amir P
AP
D000596:Amino Acids / Q000737:chemistry; D001692:Biological Transport; D018938:Caco-2 Cells; D002470:Cell Survival; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D003545:Cysteine / Q000737:chemistry; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D008956:Models, Chemical; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry*; D010539:Permeability; D013329:Structure-Activity Relationship
C530561:AT1002; D000596:Amino Acids; D009842:Oligopeptides; D010455:Peptides; D003545:Cysteine