Genetic polymorphisms as determinants for disease-preventive effects of vitamin E.
Polymorphisms in genes involved in vitamin E uptake, distribution, metabolism, and molecular action may be important determinants for the protective effects of vitamin E supplementation. The haptoglobin 2-2 polymorphism is associated with increased production of oxygen free radicals and reduces levels of vitamin E and C; the consequent elevated risk for cardiovascular disease can be prevented by vitamin E supplementation.
Zingg
Jean-Marc
JM
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Azzi
Angelo
A
Meydani
Mohsen
M
D001205:Ascorbic Acid / Q000097:blood; D019587:Dietary Supplements; D005786:Gene Expression Regulation; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D011110:Polymorphism, Genetic; D014810:Vitamin E / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D014811:Vitamin E Deficiency / Q000188:drug therapy*
C485359:HP protein, human; D006242:Haptoglobins; D014810:Vitamin E; D001205:Ascorbic Acid