Lipid redistribution in renal dysfunction.
Zhao et al. demonstrated that chronic renal failure was associated with lipid redistribution in the kidney and other organs. We discuss three types of lipid redistribution in the context of inflammatory stress, which might help to explain many conflicting clinical observations in relation to lipid-mediated renal and vascular injury. An assessment of lipid redistribution may provide a new target for therapeutic intervention.
Ruan
Xiong Z
XZ
Centre for Nephrology, Royal Free and University College Medical School, University College London, Royal Free Campus, London, United Kingdom. x.ruan@medsch.ucl.ac.uk
Moorhead
John F
JF
Varghese
Zac
Z
D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D050152:Intra-Abdominal Fat / Q000187:drug effects / Q000378:metabolism; D007668:Kidney / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology; D050356:Lipid Metabolism; D017706:Lisinopril / Q000378:metabolism / Q000494:pharmacology; D009392:Nephrectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D050151:Subcutaneous Fat / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D017706:Lisinopril