title: Heat shock proteins and neurodegenerative disorders.
abstract: Heat shock proteins (HSPs) are evolutionarily conserved molecules and play important roles in fundamental cellular processes. They serve as molecular chaperones and hence provide a protective function in ensuring cell survival and repair of cellular damage after a stressful stimulus. This paper summarizes the current knowledge about the different roles of HSPs in aging and disease, focusing on the neurodegenerative disorders of Alzheimer's marks disease, Parkinson's disease, Huntington's marks disease, and prion disease.
authors.affiliation: Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
authors.forename: Eliza Ting-Li
authors.initials: ET
authors.lastname: Soo
authors.forename: Yee-Kong
authors.initials: YK
authors.lastname: Ng
authors.forename: Boon-Huat
authors.initials: BH
authors.lastname: Bay
authors.forename: George Wai-Cheong
authors.initials: GW
authors.lastname: Yip
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D006360:Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000503:physiopathology*
chemical_list: D006360:Heat-Shock Proteins