title: Walking one hour or more per day prevented mortality among older persons: results from ilSIRENTE study.
abstract: OBJECTIVE
  Maintaining or increasing physical activity in late-middle age has been shown to be associated with a reduction in mortality. The aim of the present study was to explore the relationship between regular walking and the risk of all-cause death in a large population of frail and very old people living in community.
  
  
  METHODS
  We analyzed data from the Aging and Longevity Study in the Sirente Geographic Area (ilSIRENTE study), a prospective cohort study that collected data on all subjects aged 80 year and older living in a mountain community. Baseline assessments of participants started in December 2003 and were completed in September 2004. All subjects were followed-up for 24 months. To the purpose of this study we selected all subjects without impairment in the activities of daily living (n=248). The main outcome measure was the relative hazard ratio of death over two years of follow-up for different levels of walking activity.
  
  
  RESULTS
  During a mean follow-up time of 24 months from baseline assessment, 30 subjects (12%) died. There was an uneven distribution of the risk. After adjusting for age, gender and other possible risk factors of death (functional and cognitive disability, congestive heart failure, hypertension, osteoarthritis, depression, number of medications, body mass index, cholesterol and reactive C protein) subjects walking 1 h or more per day were less likely to die compared to participants walking less than 1 h per day (RR, 0.36; 95% CI 0.12-0.98).
  
  
  CONCLUSIONS
  Our results obtained from a representative sample of very old and frail elderly subjects expand the knowledge that high levels of walking activity are associated with better survival.
authors.affiliation: Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Roma, Italy. francesco_landi@rm.unicatt.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Landi
authors.forename: Andrea
authors.initials: A
authors.lastname: Russo
authors.forename: Matteo
authors.initials: M
authors.lastname: Cesari
authors.forename: Marco
authors.initials: M
authors.lastname: Pahor
authors.forename: Rosa
authors.initials: R
authors.lastname: Liperoti
authors.forename: Paola
authors.initials: P
authors.lastname: Danese
authors.forename: Roberto
authors.initials: R
authors.lastname: Bernabei
authors.forename: Graziano
authors.initials: G
authors.lastname: Onder
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D016330:Frail Elderly; D015438:Health Behavior; D006304:Health Status; D006801:Humans; D007558:Italy; D008136:Longevity; D008297:Male; D012111:Residence Characteristics; D015996:Survival Rate; D013997:Time Factors; D016138:Walking