Association between ABO and Rhesus blood group systems among confirmed human T lymphotropic virus type 1-infected patients in Northeast Iran.
The distribution of ABO and Rhesus blood group types was investigated in 984 randomly selected human T lymphotropic virus-1(HTLV-1)-infected blood donors from April 2004 to March 2007. A total of 1081 healthy controls admitted for blood donation in this period were enrolled in this study. Infected and control individuals were from the same region and their ABO/Rhesus blood group types were determined by the standard tube test technique. All blood samples were screened for HTLV-1 using an enzyme-linked immunosorbent assay (ELISA) and positive samples were confirmed by Western blot (WB). The unmatched analyses showed significant differences in frequency of the A+ blood group between healthy controls and HTLV-1-infected individuals (OR = 0.8, 95% CI = 0.66-0.97) and also a significant association was observed between these two groups(OR = 1.42, 95% CI = 1.1-1.99, p = 0.021). No significant difference in blood group (A-, B+, B-, O+, O-, and AB-) was observed between cases and controls. It is the first report of an association between HTLV-1-infected patients and ABO/Rh blood groups in our literature review. Our results might suggest that the A+ blood group decrease the risk of HTLV-1 infection in healthy controls, while the AB+ blood group is more frequent in HTLV-1 carriers and increases the risk of HTLV-1 infection.
Ayatollahi
H
H
Department of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran. AyatollahiH@mums.ac.ir
Rafatpanah
H
H
Khayyami
M E
ME
Sayyadpour
D
D
Ravarian
M
M
Sadeghian
M H
MH
Izadi
N
N
Khoob
M Khabbaz
MK
D000017:ABO Blood-Group System / Q000032:analysis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001782:Blood Donors; D015153:Blotting, Western / Q000379:methods; D016022:Case-Control Studies; D006800:Deltaretrovirus Infections / Q000453:epidemiology*; D004198:Disease Susceptibility; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D007113:Immunity, Innate; D007492:Iran; D008297:Male; D008875:Middle Aged; D012204:Rh-Hr Blood-Group System / Q000032:analysis*; D013223:Statistics as Topic
D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System