Selective inhibitory effects of hybrid liposomes on the growth of HIV type 1-infected cells in vitro.
A good correlation between fifty-percent inhibitory concentration (IC(50)) of hybrid liposomes (HL) composed of dimyristoylphosphatidylcholine and polyoxyethylene(n) dodecyl ether on the growth of MOLT-4/IIIB cells (MOLT-4 cells chronically infected with human immunodeficiency virus (HIV)) and the membrane fluidity of HL was obtained. Furthermore, the huge enhancement of virus production was observed in the latently HIV-infected (J(22)-HL-60) cells after the treatment with HL.
Ueoka
Ryuichi
R
Graduate Course of Applied Life Science, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan. ueoka@life.sojo-u.ac.jp
Komizu
Yuji
Y
Matsumoto
Yoko
Y
Zhong
Yu
Y
Tanaka
Ritsuko
R
Yamamoto
Naoki
N
D000818:Animals; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000378:metabolism / Q000821:virology*; D002470:Cell Survival / Q000187:drug effects; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000378:metabolism*; D018922:HL-60 Cells; D006801:Humans; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D008081:Liposomes / Q000737:chemistry / Q000627:therapeutic use*; D008560:Membrane Fluidity; D008954:Models, Biological; D008956:Models, Chemical
D008081:Liposomes