title: In vitro activity of ceftobiprole, linezolid, tigecycline, and 23 other antimicrobial agents against Staphylococcus aureus isolates in China.
abstract: We investigated the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in China and determined the susceptibility of S. aureus to 26 antimicrobial agents, including ceftobiprole, linezolid, and tigecycline. A total of 798 isolates were collected and tested by agar dilution. The mean prevalence of MRSA was 50.4%, the highest in Shanghai (80.3%), followed by those in Beijing (55.5%) and Shenyang (50.0%). Only 4.2% to 12.6% of MRSA were susceptible to erythromycin, fluoroquinolones, gentamicin, and tetracycline. All isolates were susceptible to teicoplanin, vancomycin, linezolid, tigecycline, and ceftobiprole.
authors.affiliation: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. wh_bj@tom.com
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Yudong
authors.initials: Y
authors.lastname: Liu
authors.forename: Hongli
authors.initials: H
authors.lastname: Sun
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Xu
authors.forename: Xiuli
authors.initials: X
authors.lastname: Xie
authors.forename: Minjun
authors.initials: M
authors.lastname: Chen
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D002681:China / Q000453:epidemiology; D006801:Humans; D000069349:Linezolid; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D023303:Oxazolidinones / Q000494:pharmacology*; D015995:Prevalence; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D000078304:Tigecycline
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D023303:Oxazolidinones; C443755:ceftobiprole; D000078304:Tigecycline; D008911:Minocycline; D000069349:Linezolid; D008712:Methicillin