title: Hypoxia-inducible adrenomedullin accelerates hepatocellular carcinoma cell growth.
abstract: Adrenomedullin is implicated in tumor progression and induced by hypoxia. We evaluated if adrenomedullin signaling is active in hepatocellular carcinoma (HCC), especially under hypoxic conditions, and to analyze its prognostic implication in HCC patients. HCC cells expressed adrenomedullin and its receptor, and hypoxia induced adrenomedullin expression. Adrenomedullin stimulated HCC cell growth via Akt activation, which was prevented by adrenomedullin peptide inhibitor. Clinico-pathological analysis revealed adrenomedullin extent was related to vascular invasion and N-cadherin intensity, which were reported to indicate a poor prognosis. In conclusion, adrenomedullin signaling is hypoxia-inducible and functionally active in HCCs, and its expression may be a prognostic factor.
authors.affiliation: Department of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Korea Cancer Center Hospital, Seoul, Republic of Korea.
authors.forename: Su Cheol
authors.initials: SC
authors.lastname: Park
authors.forename: Jung-Hwan
authors.initials: JH
authors.lastname: Yoon
authors.forename: Jeong-Hoon
authors.initials: JH
authors.lastname: Lee
authors.forename: Su Jong
authors.initials: SJ
authors.lastname: Yu
authors.forename: Sun Jung
authors.initials: SJ
authors.lastname: Myung
authors.forename: Won
authors.initials: W
authors.lastname: Kim
authors.forename: Geum-Youn
authors.initials: GY
authors.lastname: Gwak
authors.forename: Sung-Hee
authors.initials: SH
authors.lastname: Lee
authors.forename: Soo-Mi
authors.initials: SM
authors.lastname: Lee
authors.forename: Ja June
authors.initials: JJ
authors.lastname: Jang
authors.forename: Kyung-Suk
authors.initials: KS
authors.lastname: Suh
authors.forename: Hyo-Suk
authors.initials: HS
authors.lastname: Lee
mesh_terms: D053607:Adrenomedullin / Q000502:physiology*; D000328:Adult; D001483:Base Sequence; D015153:Blotting, Western; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D002455:Cell Division / Q000502:physiology*; D002460:Cell Line; D017931:DNA Primers; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000473:pathology*; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction
chemical_list: D017931:DNA Primers; D053607:Adrenomedullin