L-myc polymorphism in head and neck nonmelanoma skin and lower lip cancers.
OBJECTIVE
To evaluate the presence of L-myc gene variations as a genetic predisposition to head and neck nonmelanoma skin cancer (HNNMSC) and lower lip cancer (LLC).


METHODS
A case-control study.


METHODS
An academic institute laboratory.


METHODS
Twenty-four patients with HNNMSC and 27 with LLC were compared with 51 age- and sex-matched control subjects.


METHODS
Polymerase chain reaction restriction fragment length polymorphism and agarose gel electrophoresis were used to determine the L-myc oncogene genotypes.


RESULTS
The presence of the LS genotype was found to be significantly increased in the study group, whereas the LL genotype was not detected. The S allele was also more frequent in the study group. The SS genotype was found to correlate with aggressive tumor behavior in patients with HNNMSC and a family history of cancer. Patients with LLC displayed significantly less of the SS genotype.


CONCLUSIONS
The L-myc gene polymorphism may help detect and prevent HNNMSC and LLC in susceptible individuals. It may also contribute to estimation of tumor behavior in patients with HNNMSC.
Gözü
Aydin
A
Department of Plastic and Reconstructive Surgery, Vakif Gureba Research and Education Hospital, Istanbul, Turkey. aydinseye@yahoo.com
Ergen
Arzu
A
Dayicioglu
Deniz
D
Yaylim
Ilhan
I
Ozsoy
Zafer
Z
Isbir
Turgay
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002280:Basal Cell Carcinoma / Q000235:genetics* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D016259:Genes, myc / Q000235:genetics*; D006580:Genetic Carrier Screening; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000473:pathology; D006720:Homozygote; D006801:Humans; D008048:Lip Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics*; D011379:Prognosis; D012016:Reference Values; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology