Brucella: a Mr "Hide" converted into Dr Jekyll.
Dr David Bruce (1855-1931) first identified the causative agent of brucellosis as a small Gram-negative alpha-Proteobacterium, which was later on called Brucella melitensis in his honor by Meyer and Shaw. Nowadays, four strains exhibit pathogenicity in humans with B. melitensis being the least host specific and also the most infectious for humans. The other strains are Brucella suis and Brucella abortus and more recently human cases being infected with Brucella cetaceae have been reported. Why such a reemerging disease is so difficult to fight, evidence shows that the pathogenic bacterium has developed strategies to hide from immune recognition.
Gorvel
Jean-Pierre
JP
Marseille Aix Marseille Université, Faculté des Sciences de Luminy, F-13288, France. gorvel@ciml.univ-mrs.fr
D002002:Brucella / Q000276:immunology / Q000472:pathogenicity*; D002004:Brucella Vaccine / Q000276:immunology; D002006:Brucellosis / Q000276:immunology* / Q000382:microbiology* / Q000517:prevention & control; D003713:Dendritic Cells / Q000276:immunology / Q000502:physiology; D006801:Humans
D002004:Brucella Vaccine