title: [Antioxidant and antibacterial activities of dimeric phenol compounds].
abstract: We studied the antioxidant and antibacterial activities of monomeric and dimeric phenol compounds. Dimeric compounds had higher antioxidant activities than monomeric compounds. Electron spin resonance spin-trapping experiments showed that phenol compounds with an allyl substituent on their aromatic rings directly scavenged superoxide, and that only eugenol trapped hydroxyl radicals. We developed a generation system of the hydroxyl radical without using any metals by adding L-DOPA and DMPO to PBS or MiliQ water in vitro. We found that eugenol trapped hydroxyl radicals directly and is metabolized to a dimer. On the other hand, dipropofol, a dimer of propofol, has strong antibacterial activity against Gram-positive bacteria. However, it lacks solubility in water and this property is assumed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water with the addition of a monosaccharide or ascorbic acid.
authors.affiliation: Faculty of Pharmaceutical Sciences, Aomori University, Aomori City, Japan. ogata-ms@aomori-u.ac.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ogata
mesh_terms: D000473:Alkanes / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000975:Antioxidants; D001205:Ascorbic Acid; D019281:Dimerization; D024881:Drug Resistance, Bacterial; D005054:Eugenol / Q000737:chemistry / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D012995:Solubility; D014867:Water
chemical_list: D000473:Alkanes; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D010636:Phenols; C504748:dipropofol; D014867:Water; D005054:Eugenol; D001205:Ascorbic Acid