title: New molecular techniques for the prenatal detection of chromosomal aneuploidy.
abstract: OBJECTIVE
  To review the molecular genetic techniques currently available for rapid prenatal diagnosis of fetal aneuploidy, as well as those still under investigation.
  
  
  METHODS
  Limited to introductory discussion of rapid aneuploidy detection methods.
  
  
  METHODS
  Medline was searched for articles related to the topic that were published after 1992. This document represents an abstraction of the information.
  
  
  METHODS
  This update was prepared by the Genetics Committee of the Society of Obstetricians and Gynaecologists of Canada approved by the Executive and Council of the Society of Obstetricians and Gynaecologists of Canada.
  
  
  RESULTS
  This update provides information about methods of rapid aneuploidy detection using molecular techniques and the evidence supporting their use in prenatal diagnosis. These methods are reliable and cost-effective for detecting the targeted fetal aneuploidies, but are limited in their ability to detect non-aneuploid chromosome abnormalities, some of which are clinically significant.
authors.affiliation: Calgary AB, Canada.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Sparkes
authors.forename: Jo-Ann
authors.initials: JA
authors.lastname: Johnson
authors.forename: Sylvie
authors.initials: S
authors.lastname: Langlois
authors.forename: R Douglas
authors.initials: RD
authors.lastname: Wilson
authors.forename: Victoria
authors.initials: V
authors.lastname: Allen
authors.forename: Claire
authors.initials: C
authors.lastname: Blight
authors.forename: Valérie
authors.initials: V
authors.lastname: Désilets
authors.forename: Alain
authors.initials: A
authors.lastname: Gagnon
authors.forename: Jo-Ann
authors.initials: JA
authors.lastname: Johnson
authors.forename: Sylvie
authors.initials: S
authors.lastname: Langlois
authors.forename: Anne
authors.initials: A
authors.lastname: Summers
authors.forename: Phil
authors.initials: P
authors.lastname: Wyatt
mesh_terms: D000782:Aneuploidy; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015336:Molecular Probe Techniques; D021141:Nucleic Acid Amplification Techniques / Q000379:methods; D011247:Pregnancy; D011296:Prenatal Diagnosis