title: Effect of sodium carbonate solution on self-setting properties of tricalcium silicate bone cement.
abstract: In this study, the effects of sodium carbonate (Na(2)CO(3) ) solution with different concentrations (10, 15, 20, and 25 wt%) as liquid phase on the setting time and compressive strength of tricalcium silicate bone cements are investigated. The in vitro bioactivity and degradability of the resultant Ca(3)SiO(5)-Na(2)CO(3) solution paste was also studied. The results indicate that as the concentration of Na(2)CO(3) solution varies from 0 to 25 wt%, the initial and final setting time of the cement decrease significantly from 90 to 20 min and from 180 to 45 min, respectively. After setting for 24 h, the compressive strength of Ca(3)SiO(5)-Na(2)CO(3) solution paste reaches 5.1 MPa, which is significantly higher than that of Ca( 3)SiO(5)-water cement system. The in vitro bioactivity of the cements is investigated by soaking in simulated body fluid (SBF) for 7 days. The results show that the Ca(3)SiO(5)-Na(2)CO( 3) solution bone cement has a good bioactivity and can degrade in Ringer's solution. The results indicate that Na(2)CO(3) solution as a liquid phase significantly improves the self-setting properties of Ca( 3)SiO(5) cement as compared to water. The Ca(3)SiO( 5) cement paste prepared using Na(2)CO(3) solution shows good bioactivity and moderate degradability, and the Ca(3)SiO( 5)-Na(2)CO(3) solution system may be used as degradable and bioactive bone defect filling materials.
authors.affiliation: Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China.
authors.lastname: Zhiguang Huan
authors.lastname: Jiang Chang
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry; D001826:Body Fluids / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry*; D017610:Calcium Compounds / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry*; D002484:Cementation / Q000379:methods*; D006244:Hardness; D006245:Hardness Tests; D008422:Materials Testing; D017640:Silicates / Q000737:chemistry*; D012996:Solutions
chemical_list: D001843:Bone Cements; D017610:Calcium Compounds; D002254:Carbonates; D017640:Silicates; D012996:Solutions; C506393:tricalcium silicate; C005686:sodium carbonate