New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance.
To further define the function of the oxytocin receptor (OXTR) in vivo, we generated mice deficient in the Oxtr gene (Oxtr-/-). Oxtr-/- mice had no obvious deficits in fertility or sexual behaviour, but displayed several aberrations in social behaviours, including male aggression, and mother-offspring interaction. In addition, they showed novel physiological defects including obesity, and dysfunction in body temperature control when exposed to cold. We review here our new findings with Oxtr-/- mice, and introduce newly generated Oxtr-Venus knockin mice as a potential tool for examining molecular physiology of Oxtr-neurons.
Nishimori
Katsuhiko
K
Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan.
Takayanagi
Yuki
Y
Yoshida
Masahide
M
Kasahara
Yoshiyuki
Y
Young
Larry J
LJ
Kawamata
Masaki
M
D000818:Animals; D001794:Blood Pressure; D001831:Body Temperature; D004327:Drinking Behavior; D004734:Energy Metabolism; D005247:Feeding Behavior; D005260:Female; D006339:Heart Rate; D007031:Hypothalamus / Q000502:physiology*; D007774:Lactation; D008297:Male; D008425:Maternal Behavior; D051379:Mice; D018345:Mice, Knockout; D008892:Milk / Q000378:metabolism; D009215:Myometrium / Q000502:physiology; D010121:Oxytocin / Q000172:deficiency* / Q000235:genetics* / Q000502:physiology; D011247:Pregnancy; D018045:Receptors, Oxytocin / Q000172:deficiency* / Q000235:genetics / Q000502:physiology*; D012726:Sexual Behavior, Animal; D012919:Social Behavior
D018045:Receptors, Oxytocin; D010121:Oxytocin