title: Synthesis of bioinorganic antimicrobial peptide nanoparticles with potential therapeutic properties.
abstract: Amphiphilicity and cationicity are properties shared between antimicrobial peptides and proteins that catalyze biomineralization reactions. Merging these two functionalities, we demonstrate a reaction where a cationic antimicrobial peptide catalyzes self-biomineralization within inorganic matrices. The resultant antimicrobial peptide nanoparticles retain biocidal activity, protect the peptide from proteolytic degradation, and facilitate a continuous release of the antibiotic over time. Taken together, these properties demonstrate the therapeutic potential of self-synthesizing biomaterials that retain the biocidal properties of antimicrobial peptides.
authors.affiliation: Universal Technology Corporation, Applied Research Associates, Inc., Florida, USA. matt.eby.ctr@tyndall.af.mil
authors.forename: D Matthew
authors.initials: DM
authors.lastname: Eby
authors.forename: Karen E
authors.initials: KE
authors.lastname: Farrington
authors.forename: Glenn R
authors.initials: GR
authors.lastname: Johnson
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects*; D002384:Catalysis; D002412:Cations / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004058:Diffusion; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects*; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D002412:Cations; D009842:Oligopeptides; C009495:titanium dioxide; D012822:Silicon Dioxide; D014025:Titanium