Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.
In order to study the effect of 5'-modification of 2'-deoxynucleoside on its anti-HCV activity, several analogues were synthesized and evaluated. Among the analogues, a 5'-deoxy-5'-phenacylated analogue exhibited a good anti-HCV activity with an EC(50) of 15.1 microM. This compound is expected to operate via a type of mechanism that does not involve a generally known 5'-O-triphosphorylation process.
Ikejiri
Masahiro
M
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan. ikejim@osaka-ohtani.ac.jp
Ohshima
Takayuki
T
Fukushima
Akemi
A
Shimotohno
Kunitada
K
Maruyama
Tokumi
T
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004279:DNA, Viral / Q000378:metabolism; D003839:Deoxyadenosines / Q000737:chemistry* / Q000378:metabolism; D015195:Drug Design; D016174:Hepacivirus / Q000187:drug effects*; D006526:Hepatitis C / Q000188:drug therapy; D006801:Humans; D008956:Models, Chemical; D009705:Nucleosides / Q000737:chemistry; D010766:Phosphorylation; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D004279:DNA, Viral; D003839:Deoxyadenosines; D009705:Nucleosides; C058118:2'-deoxyadenosine