Differential effects of ziprasidone and haloperidol on immobilization stress-induced mRNA BDNF expression in the hippocampus and neocortex of rats.
Recent in vivo and in vitro experiments have demonstrated that second-generation antipsychotic drugs (SGAs) might have neuroprotective effects. Ziprasidone is a SGA that is efficacious in the treatment of schizophrenia. In this study, we sought to analyze the effects of ziprasidone on the expression of the neuroprotective protein brain-derived neurotrophic factor (BDNF) in the rat hippocampus and neocortex, with or without immobilization stress. The effect of ziprasidone (2.5mg/kg) on the expression of BDNF mRNA was determined by in situ hybridization in tissue sections from the rat hippocampus and neocortex. Haloperidol (1.0mg/kg) was used for comparison. Haloperidol strongly decreased the expression of BDNF mRNA in both the hippocampal and cortical regions, with or without immobilization stress (p<0.01). In contrast, the administration of ziprasidone significantly attenuated the immobilization stress-induced decrease in BDNF mRNA expression in the rat hippocampus and neocortex (p<0.01). Ziprasidone exhibited differential effects on BDNF mRNA expression in the rat hippocampus and neocortex. These results suggest that ziprasidone might have a neuroprotective effect by recovering stress-induced decreases in BDNF mRNA expression.
Park
Sung Woo
SW
Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea.
Lee
Chan Hong
CH
Lee
Jung Goo
JG
Lee
Sun Jung
SJ
Kim
Na Ri
NR
Choi
Sang Mi
SM
Kim
Young Hoon
YH
D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D017403:In Situ Hybridization / Q000379:methods; D007274:Injections, Intraperitoneal; D008297:Male; D019579:Neocortex / Q000187:drug effects* / Q000378:metabolism; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical / Q000009:adverse effects; D013315:Stress, Psychological / Q000209:etiology / Q000503:physiopathology*; D013844:Thiazoles / Q000008:administration & dosage / Q000494:pharmacology*
D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor; D010879:Piperazines; D012333:RNA, Messenger; D013844:Thiazoles; C092292:ziprasidone; D006220:Haloperidol