Photothermal response of superparamagnetic iron oxide nanoparticles.
OBJECTIVE
Superparamagnetic iron oxide nanoparticles have been used as MRI contrast agents in medical imaging. The purpose of this study was to explore the photothermal response of superparamagnetic iron oxide nanoparticles for biomedical applications.


METHODS
Absorbance, temperature increase, and optical path length change of solutions of superparamagnetic iron oxide nanoparticles, SPIO and MION, in response to a 532 nm pulsed laser irradiation were measured.


RESULTS
Both SPIO and MION showed absorption at 532 nm, temperature increase, and optical path length change. SPIO and MION underwent selective heating due to absorption of laser energy (532 nm).


CONCLUSIONS
Temperature increase and optical path length change of SPIO and MION in response to 532 nm pulsed laser irradiation demonstrate a potential application of these particles in biomedical imaging. For further study, additional experiments applying the photothermal response of SPIO and MION in tissues are required.
Kim
Jihoon
J
Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208, USA. jihoon-kim@northwestern.edu
Oh
Junghwan
J
Kang
Hyun Wook
HW
Feldman
Marc D
MD
Milner
Thomas E
TE
D002478:Cells, Cultured / Q000473:pathology / Q000528:radiation effects*; D052203:Ferrosoferric Oxide / Q000494:pharmacology; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D028022:Low-Level Light Therapy; D053758:Nanoparticles; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence
C499827:monocrystalline iron oxide nanoparticle; D052203:Ferrosoferric Oxide