title: SAPHO syndrome associated spondylitis.
abstract: The concept of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome has been well clarified, after Chamot et al. suggested this peculiar disorder in 1987. The most commonly affected site in SAPHO syndrome is the anterior chest, followed by the spine. However, the clinical course and taxonomic concept of SAPHO spinal lesions are poorly understood. This study was performed to analyze: (1) the detailed clinical course of spinal lesions in SAPHO syndrome, and (2) the relationship between SAPHO syndrome with spinal lesions and seronegative spondyloarthropathy. Thirteen patients with spondylitis in SAPHO syndrome were analyzed. The features of spinal lesions were a chronic onset with a slight inflammatory reaction, and slowly progressing non-marginal syndesmophytes at multi spinal levels, besides the coexistence of specific skin lesions. SAPHO syndrome, especially spinal lesions related to palmoplantar pustulosis, can be recognized as a subtype of seronegative spondyloarthropathy.
authors.affiliation: Department of Orthopaedic Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama City, Okayama, 700-8558, Japan. takigawa2004@yahoo.co.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Takigawa
authors.forename: Masato
authors.initials: M
authors.lastname: Tanaka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Haruo
authors.initials: H
authors.lastname: Misawa
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Sugimoto
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Takahata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakahara
authors.forename: Shinnosuke
authors.initials: S
authors.lastname: Nakahara
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Ozaki
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013166:Spondylitis / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*