title: Asymmetric synthesis of (+)-isofebrifugine and (-)-sedacryptine from a common chiral nonracemic building block.
abstract: The stereoselective syntheses of 2-substituted and 2,6-disubstituted 3-hydroxypiperidine alkaloids, (+)-isofebrifugine and (-)-sedacryptine, from a common, functionalized nonracemic bicyclic building block are achieved, demonstrating the flexibilty of the approach.
authors.affiliation: Department of Chemistry and Biochemistry, University of Regina, Regina, Saskatchewan, Canada S4S 0A2. andrew.wee@uregina.ca
authors.forename: Andrew G H
authors.initials: AG
authors.lastname: Wee
authors.forename: Gao-Jun
authors.initials: GJ
authors.lastname: Fan
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis*; D010880:Piperidines / Q000138:chemical synthesis*; D010881:Piperidones; D011799:Quinazolines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D010880:Piperidines; D010881:Piperidones; D011799:Quinazolines; C532856:sedacryptine; C001207:febrifugine