title: Acute aortic syndromes: pathophysiology and management.
abstract: The acute aortic syndromes carry significant morbidity and mortality, especially when detected late. Symptoms may mimic myocardial ischemia, and physical findings may be absent or, if present, can be suggestive of a diverse range of other conditions. Maintaining a high clinical index of suspicion is crucial in establishing the diagnosis. All patients with suspected aortic disease and evidence of acute ischemia on electrocardiogram should undergo diagnostic imaging studies before thrombolytics are administered. The demonstration of an intimal flap separating 2 lumina is the basis for diagnosis. Tear detection and localization are very important because any therapeutic intervention aims to occlude the entry tear. The goals of medical therapy are to reduce the force of left ventricular contractions, decrease the steepness of the rise of the aortic pulse wave, and reduce the systemic arterial pressure to as low a level as possible without compromising perfusion of vital organs. Surgical therapy still remains the gold standard of care for type A aortic dissection, whereas in type B dissection, percutaneous aortic stenting and fenestration techniques have been developed and are sometimes used in conjunction with medical therapy in certain situations.
authors.affiliation: Division of Cardiovascular Disease, Department of Medicine, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA.
authors.forename: Oluseun
authors.initials: O
authors.lastname: Alli
authors.forename: Larry
authors.initials: L
authors.lastname: Jacobs
authors.forename: Aman M
authors.initials: AM
authors.lastname: Amanullah
mesh_terms: D000208:Acute Disease; D000784:Aortic Dissection / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D001014:Aortic Aneurysm / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D001018:Aortic Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000150:complications; D017202:Myocardial Ischemia / Q000175:diagnosis; D019966:Substance-Related Disorders / Q000150:complications; D013577:Syndrome; D017539:Tunica Intima / Q000503:physiopathology; D014656:Vascular Surgical Procedures
chemical_list: D005343:Fibrinolytic Agents