title: Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk.
abstract: The alkyl-lysophospholipids edelfosine and miltefosine induce apoptosis in Leishmania infantum promastigotes. The finding that edelfosine-induced cell death can be regulated by the ectopic expression of the antiapoptotic and proapoptotic members of the Bcl-2 family of proteins Bcl-X(L) and Hrk suggests that this process is similar to apoptosis in eukaryotic cells.
authors.affiliation: Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Juan Fernando
authors.initials: JF
authors.lastname: Alzate
authors.forename: Andrés
authors.initials: A
authors.lastname: Arias
authors.forename: Faustino
authors.initials: F
authors.lastname: Mollinedo
authors.forename: Eva
authors.initials: E
authors.lastname: Rico
authors.forename: Janis
authors.initials: J
authors.lastname: de la Iglesia-Vicente
authors.forename: Antonio
authors.initials: A
authors.lastname: Jiménez-Ruiz
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism; D018314:Leishmania infantum / Q000166:cytology / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D010742:Phospholipid Ethers / Q000494:pharmacology*; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000494:pharmacology; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D014162:Transfection; D051020:bcl-X Protein / Q000235:genetics / Q000378:metabolism
chemical_list: D000981:Antiprotozoal Agents; D051017:Apoptosis Regulatory Proteins; D010742:Phospholipid Ethers; D011994:Recombinant Proteins; D051020:bcl-X Protein; D010767:Phosphorylcholine; C026659:edelfosine; C039128:miltefosine