title: Coupling across a DNA helical turn yields a hybrid DNA/organic catenane doubly tailed with functional termini.
abstract: We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.
authors.affiliation: Department of Chemistry, New York University, New York, New York 10003, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Akinori
authors.initials: A
authors.lastname: Kuzuya
authors.forename: Ruojie
authors.initials: R
authors.lastname: Sha
authors.forename: Johan
authors.initials: J
authors.lastname: Guillaume
authors.forename: Risheng
authors.initials: R
authors.lastname: Wang
authors.forename: James W
authors.initials: JW
authors.lastname: Canary
authors.forename: Nadrian C
authors.initials: NC
authors.lastname: Seeman
mesh_terms: D000873:Anthracenes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000528:radiation effects; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry / Q000528:radiation effects; D013237:Stereoisomerism; D014466:Ultraviolet Rays
chemical_list: D000873:Anthracenes; D009841:Oligonucleotides; C467767:catenane; D004247:DNA