title: Structural proteomics of dengue virus.
abstract: In this paper, we discuss recent advances in our knowledge of the dengue virus life cycle based on new structural data of the virus and its proteins. Specifically, we focus on the structure of the pre-membrane protein, prM and its role in virus assembly, the first full-length structure of a multi-domain dengue virus replication protein, NS3, and the recently solved structures of NS5 methyltransferase and polymerase domains. These structures provide a basis for describing function and predicting putative host interactions.
authors.affiliation: Markey Center for Structural Biology & Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, United States.
authors.forename: Rushika
authors.initials: R
authors.lastname: Perera
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Kuhn
mesh_terms: D003716:Dengue Virus / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D008958:Models, Molecular; D020836:Protein Structure, Quaternary; D040901:Proteomics; D017361:Viral Nonstructural Proteins / Q000737:chemistry* / Q000235:genetics; D019065:Virus Assembly
chemical_list: D017361:Viral Nonstructural Proteins