New visions for atopic eczema: an iPAC summary and future trends.
Atopic eczema (AE) is a chronic inflammatory skin disease characterized by pruritus, dry skin and an ongoing course of exacerbations and remissions. AE is a common disorder in children with a worldwide cumulative prevalence of 15-20% in this age group. AE has a strong familial predisposition. While AE is a complex disease with multiple gene involvement, recent interest has focused on genes involved in skin barrier/epidermal differentiation and in immune response/host defense. Recent developments and future directions on pathogenesis, diagnosis, natural course and prognosis are discussed.
Rancé
Fabienne
F
Hôpital des Enfants, Toulouse, France. rance.f@chu-toulouse.fr
Boguniewicz
Mark
M
Lau
Susanne
S
D002675:Child, Preschool; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D003876:Dermatitis, Atopic / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology* / Q000628:therapy; D003937:Diagnosis, Differential; D000091344:Filaggrin Proteins; D020022:Genetic Predisposition to Disease; D006801:Humans; D007073:Immunoglobulin E / Q000235:genetics / Q000276:immunology; D007223:Infant; D007381:Intermediate Filament Proteins / Q000235:genetics; D015995:Prevalence; D011379:Prognosis; D012879:Skin Physiological Phenomena
D016207:Cytokines; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D007073:Immunoglobulin E