G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan.
Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P=1.91 x 10(-14); OR=3.94; 95% CI=2.74-5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P=0.033; OR=4.21; 95% CI=1.01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P=0.019; OR=0.41; 95% CI=0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE.
Lin
Ying-Ju
YJ
Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Wan
Lei
L
Sheu
Jim Jinn-Chyuan
JJ
Huang
Chung-Ming
CM
Lin
Cheng-Wen
CW
Lan
Yu-Ching
YC
Lai
Chih-Ho
CH
Hung
Chien-Hui
CH
Tsai
Yuhsin
Y
Tsai
Chang-Hai
CH
Lin
Wei-Yong
WY
Liu
Hsin-Ping
HP
Lin
Ting-Hsu
TH
Huang
Yu-Min
YM
Tsai
Fuu-Jen
FJ
D000483:Alleles; D005091:Exons; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D013624:Taiwan
D007376:Interleukin-2