title: Streptopyrrolidine, an angiogenesis inhibitor from a marine-derived Streptomyces sp. KORDI-3973.
abstract: Streptopyrrolidine, a benzyl pyrrolidine derivative, was isolated as an angiogenesis inhibitor from the fermentation broth of a marine Streptomyces sp. isolated from the deep sea sediment. Its structure was elucidated by extensive 2D NMR and mass spectroscopic analyses. Streptopyrrolidine exhibited significant anti-angiogenesis activity.
authors.affiliation: Marine Natural Products Laboratory, Korea Ocean Research & Development Institute, Ansan P.O. Box 29, Seoul 425-600, Republic of Korea. shinhj@kordi.re.kr
authors.forename: Hee Jae
authors.initials: HJ
authors.lastname: Shin
authors.forename: Tae Sik
authors.initials: TS
authors.lastname: Kim
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Jung Youl
authors.initials: JY
authors.lastname: Park
authors.forename: In-Kwon
authors.initials: IK
authors.lastname: Choi
authors.forename: Ho Jeong
authors.initials: HJ
authors.lastname: Kwon
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D011759:Pyrrolidines / Q000737:chemistry / Q000494:pharmacology*; D012623:Seawater / Q000382:microbiology; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000302:isolation & purification; D014471:Umbilical Veins
chemical_list: D020533:Angiogenesis Inhibitors; D011759:Pyrrolidines; D004121:Dimethyl Sulfoxide