title: Synthesis and biological evaluation of C-12' substituted vinflunine derivatives.
abstract: A series of novel C-12' substituted vinflunine derivatives have been synthesized. Several compounds in this series possess comparable in vitro cytotoxic potency against A549 cell lines.
authors.affiliation: Shanghai Hengrui Pharmaceuticals Co., Ltd., 279 Wenjing Road, Shanghai 200245, China.
authors.forename: Xin Sheng
authors.initials: XS
authors.lastname: Lei
authors.forename: Xiang Da
authors.initials: XD
authors.lastname: Yu
authors.forename: Long
authors.initials: L
authors.lastname: Yin
authors.forename: Zhen Hong
authors.initials: ZH
authors.lastname: Liu
authors.forename: Peng Cho
authors.initials: PC
authors.lastname: Tang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008870:Microtubules / Q000737:chemistry; D008956:Models, Chemical; D008968:Molecular Conformation; D019810:Sodium Azide / Q000494:pharmacology; D014404:Tubulin / Q000737:chemistry; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014404:Tubulin; C111217:vinflunine; D014747:Vinblastine; D019810:Sodium Azide