title: Variation in basal heat shock protein 70 is correlated to core temperature in human subjects.
abstract: Heat shock proteins are highly conserved proteins and play an important chaperone role in aiding the folding of nascent proteins within cells. The heat shock protein response to various stressors, both in vitro and in vivo, is well characterised. However, basal levels of heat shock protein 70 (Hsp70) have not previously been investigated. Monocyte-expressed Hsp70 was determined every 4 h, over a 24 h time period, in 17 healthy male subjects (177 +/- 6.4 cm, 75.7 +/- 10.9 kg, 19.8 +/- 4.3 years) within a temperature and activity controlled environment. Core temperature was measured at 5-min intervals during the 24 h period. Hsp70 showed significant diurnal variation (F = 7.4; p < 0.001), demonstrating peaks at 0900 and 2100 hours, and a nadir at 05.00. Core temperature followed a similar temporal trend (range = 35.96-38.10 degrees C) and was significantly correlated with Hsp70 expression (r(s) = 0.44; p < 0.001). These findings suggest a high responsiveness of Hsp70 expression in monocytes to slight variations in core temperature.
authors.affiliation: Department of Sport, Health and Exercise Science, University of Hull, Cottingham Road, Hull HU6 7RX, UK.
authors.forename: Marie E
authors.initials: ME
authors.lastname: Sandström
authors.forename: Leigh A
authors.initials: LA
authors.lastname: Madden
authors.forename: Lee
authors.initials: L
authors.lastname: Taylor
authors.forename: Jason C
authors.initials: JC
authors.lastname: Siegler
authors.forename: Ric J
authors.initials: RJ
authors.lastname: Lovell
authors.forename: Adrian
authors.initials: A
authors.lastname: Midgley
authors.forename: Lars
authors.initials: L
authors.lastname: McNaughton
mesh_terms: D000293:Adolescent; D001831:Body Temperature; D002940:Circadian Rhythm / Q000502:physiology; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D009000:Monocytes / Q000378:metabolism; D055815:Young Adult
chemical_list: D018840:HSP70 Heat-Shock Proteins