title: Immunoglobulin kappa gene repertoire and somatic hypermutation patterns in follicular lymphoma.
abstract: Immunoglobulin kappa gene usage and somatic mutation patterns were studied in a series of 47 IGKV-J rearrangements amplified in 42 follicular lymphoma (FL) cases. The IGKV1-39/1D-39 gene predominated and was significantly over-represented compared to normal cells, autoreactive cells or other B cell lymphomas. The impact of somatic hypermutation varied significantly; nevertheless, mutation distribution patterns indicated pressure for preservation of the B cell receptor. In conclusion, the present series demonstrates biased usage of IGKV genes in FL and alludes to the important role of immunoglobulin kappa light chains in antigen selection of the clonogenic B cells in FL.
authors.affiliation: Hematology Department and Hematopoietic Cell Transplantation Unit, G. Papanicolaou Hospital, 57010 Asvestohori, Thessaloniki, Greece.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Smilevska
authors.forename: Eugenia
authors.initials: E
authors.lastname: Tsakou
authors.forename: Anastasia
authors.initials: A
authors.lastname: Hadzidimitriou
authors.forename: Vasilis
authors.initials: V
authors.lastname: Bikos
authors.forename: Niki
authors.initials: N
authors.lastname: Stavroyianni
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Laoutaris
authors.forename: Alphathanasios
authors.initials: A
authors.lastname: Fassas
authors.forename: Achilles
authors.initials: A
authors.lastname: Alphanagnostopoulos
authors.forename: Theodora
authors.initials: T
authors.lastname: Papadaki
authors.forename: Chrysoula
authors.initials: C
authors.lastname: Belessi
authors.forename: Kostas
authors.initials: K
authors.lastname: Stamatopoulos
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D002999:Clone Cells; D015321:Gene Rearrangement; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D008224:Lymphoma, Follicular / Q000235:genetics* / Q000473:pathology; D011947:Receptors, Antigen, B-Cell / Q000235:genetics; D027041:Somatic Hypermutation, Immunoglobulin
chemical_list: D007145:Immunoglobulin kappa-Chains; D011947:Receptors, Antigen, B-Cell