[Effect of adrenaline on the cytochrome P4502E1 content in microsomes and lysosomal fractions induced by isoniazid in rats].
Cytochrome P4502E1 levels in microsomal and lysosomal liver fractions was studied in Wistar rats treated with epinephrine (5.5 x 10(-6) mole/g, i.p., 1 h before test) on the background of isoniazid administration (daily dose 250 mg/kg, i.p., for 3 days). Epinephrine administration resulted in increased cytochrome P4502E1 level in the vacuole/lysosome apparatus of rat liver. On the background of isoniazid administration, cytochrome P4502E1 level and p-nitrophenol-hydroxylase activity in both low- and high-density lysosomes were decreased. Epinephrine administration under these conditions increased the cytochrome P-4502E1 level in lysosomes due to autophagy.
Vokhmintseva
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D000818:Animals; D001343:Autophagy / Q000187:drug effects; D019392:Cytochrome P-450 CYP2E1 / Q000096:biosynthesis*; D004837:Epinephrine / Q000494:pharmacology*; D054872:Fatty Acid Synthesis Inhibitors / Q000494:pharmacology; D005260:Female; D007538:Isoniazid / Q000494:pharmacology*; D008247:Lysosomes / Q000187:drug effects* / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D054872:Fatty Acid Synthesis Inhibitors; D019392:Cytochrome P-450 CYP2E1; D007538:Isoniazid; D004837:Epinephrine