title: Metal-free artificial nucleases based on simple oxime and hydroxylamine scaffolds.
abstract: Hydrolysis of DNA is of increasing importance in biotechnology and medicine. In this Letter, we present the DNA-cleavage potential of metal-free hydroxylamines and oximes as new members of nucleic acid cleavage agents.
authors.affiliation: Departamento de Bioquímica Universidade Federal de Santa Catarina, Campus Universitário-Trindade, 88040-900 Florianópolis, SC, Brazil.
authors.forename: Luciano
authors.initials: L
authors.lastname: Fernandes
authors.forename: Franciele L
authors.initials: FL
authors.lastname: Fischer
authors.forename: Carolina W
authors.initials: CW
authors.lastname: Ribeiro
authors.forename: Gustavo P
authors.initials: GP
authors.lastname: Silveira
authors.forename: Marcus M
authors.initials: MM
authors.lastname: Sá
authors.forename: Faruk
authors.initials: F
authors.lastname: Nome
authors.forename: Hernán
authors.initials: H
authors.lastname: Terenzi
mesh_terms: D002621:Chemistry / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D003851:Deoxyribonucleases / Q000138:chemical synthesis* / Q000737:chemistry*; D004214:Distamycins / Q000494:pharmacology; D015195:Drug Design; D005990:Glycerol / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D006898:Hydroxylamines / Q000737:chemistry*; D007700:Kinetics; D008670:Metals / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000737:chemistry; D010091:Oximes / Q000737:chemistry*; D012997:Solvents
chemical_list: D004214:Distamycins; D006898:Hydroxylamines; D008670:Metals; D009696:Nucleic Acids; D010091:Oximes; D012997:Solvents; C030000:stallimycin; D004247:DNA; D003851:Deoxyribonucleases; D005990:Glycerol