title: Molecular targeted therapies for breast cancer treatment.
abstract: Targeting the oestrogen receptor, HER2 (human epidermal growth factor receptor 2) and vascular endothelial growth factor has markedly improved breast cancer therapy. New targeted therapeutic approaches to induction of apoptosis or inhibition of anti-apoptosis, cell cycle progression, signal transduction and angiogenesis are described. The molecular pathways and their inhibitory or repair mechanisms are discussed in the preclinical and clinical settings.
authors.affiliation: Department of Obstetrics and Gynecology, Breast Centre Klinikum Lüdenscheid, Academic Teaching Hospital of the University Bonn, Luedenscheid, Paulmannshoeher Str, 14 - 58515 Luedenscheid Germany.
authors.forename: Claus M
authors.initials: CM
authors.lastname: Schlotter
authors.forename: Ulf
authors.initials: U
authors.lastname: Vogt
authors.forename: Heike
authors.initials: H
authors.lastname: Allgayer
authors.forename: Burkhard
authors.initials: B
authors.lastname: Brandt
mesh_terms: D017209:Apoptosis; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D002453:Cell Cycle; D045744:Cell Line, Tumor; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D006801:Humans; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D009389:Neovascularization, Pathologic; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D015398:Signal Transduction; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D066246:ErbB Receptors; D016328:NF-kappa B; D046988:Proteasome Endopeptidase Complex; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D025801:Ubiquitin; C508053:ERBB2 protein, human