Effect of pancragen on blood glucose level, capillary permeability and adhesion in rats with experimental diabetes mellitus.
The effects of tetrapeptide pancragen (Lys-Glu-Asp-Trp-NH2) on blood glucose level and permeability and adhesion of mesenteric capillaries were studied in Wistar rats with experimental streptozotocin-induced diabetes mellitus. Oral pancragen produced a pronounced hypoglycemic effect during treatment. Intramuscular pancragen normalized the adhesion of mesenteric capillary endothelium, but did not modify capillary permeability. The results indicate homeostatic and endothelioprotective effects of pancragen during the early period of diabetes mellitus.
Khavinson
V Kh
VKh
St. Petersburg Institute of Bioregulation and Gerontology, NorthWestern Division of Russian Academy of Medical Sciences.
Gavrisheva
N A
NA
Malinin
V V
VV
Chefu
S G
SG
Trofimov
E L
EL
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002199:Capillary Permeability / Q000187:drug effects*; D002448:Cell Adhesion / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D007273:Injections, Intramuscular; D008297:Male; D008643:Mesentery / Q000098:blood supply; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D001786:Blood Glucose; D009842:Oligopeptides; C511188:lysyl-glutamyl-aspartyl-tryptophan; C531938:lysyl-glutamyl-aspartyl-tryptophanamide; D013311:Streptozocin