Protection studies against Marek's disease using baculovirus-expressed glycoproteins B and C of Marek's disease virus type 1.
Glycoproteins B (MDV1-gB) and C (MDV1-gC) of Marek's disease virus type 1 (MDV 1) expressed by baculovirus recombinants [rAcNPV(s)] were investigated for their ability to confer protective immunity in chickens against virulent MDV1 challenge. Immunization of chickens with rAcNPV-expressed MDV1-gB induced antibody against MDV1 and resulted in strong protection against the lethal challenge with MDV1. In contrast, immunization of chickens with rAcNPV-expressed MDV1-gC induced antibody against MDV1, but failed to protect against challenge with the virulent MDV1. Co-immunization with both rAcNPV-expressed MDV1-gB and MDV1-gC seemed to show no synergistic effect.
Jang
H K
HK
Department of Veterinary Microbiology, Faculty of Agriculture, University of Tokyo, Tokyo, 113, Japan.
Kitazawa
T
T
Ono
M
M
Kawaguchi
Y
Y
Maeda
K
K
Yokoyama
N
N
Tohya
Y
Y
Niikura
M
M
Mikami
T
T