Carbopol 974P in the prescription of dental anti-inflammatory hydrogels.
The aim of this study was to assess applicative properties of the produced acc. to own prescription dental anti-inflammatory hydrogel with Carbopol 974P. Ketoprofen pharmaceutical availability was tested from hydrogel with Carbopol 974P and to compare - from hydrogels of similar prescription produced on the base of xanthan gum carboxymethylcellulose sodium salt. Very high pharmaceutical availability of ketoprofen was obtained from hydrogel with Carbopol 974P which is related to specific linear crosslinking of polyacrylic acid. The tests of physicochemical properties of hydrogel with Carbopol 974P demonstrated that it has high pH not creating the risk of demineralisation after its application in oral cavity. Introduction of zinc chloride into the prescription of hydrogel with Carbopol 974P improves rheological parameters of the preparation i.e. decreases structural viscosity, the value of yield stress and increases extensibility but decreases ketoprofen pharmaceutical availability by about 15%.
Kołodziejska
Justyna
J
Department of Drug Form Technology, Applied Pharmacy Faculty Medical University in Lodz.
D000179:Acrylates / Q000737:chemistry*; D000180:Acrylic Resins / Q000737:chemistry; D000284:Administration, Oral; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry*; D019540:Area Under Curve; D001682:Biological Availability; D002712:Chlorides / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D004355:Drug Stability; D020100:Hydrogels / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007660:Ketoprofen / Q000008:administration & dosage* / Q000737:chemistry*; D053210:Pharmaceutical Preparations, Dental / Q000008:administration & dosage* / Q000737:chemistry*; D012212:Rheology; D014783:Viscosity; D017967:Zinc Compounds / Q000737:chemistry
D000179:Acrylates; D000180:Acrylic Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002712:Chlorides; D003432:Cross-Linking Reagents; D020100:Hydrogels; D053210:Pharmaceutical Preparations, Dental; D017967:Zinc Compounds; C117167:carbopol 974P NF; C006903:carbopol 940; C016837:zinc chloride; D007660:Ketoprofen