Relationship between developmental synaptic modulation and conditioning-induced synaptic change in Lymnaea.
Though adult Lymnaea are bimodal breathers, young animals breathe mainly through the skin and adults through the lung. Operant conditioning changes adult breathing behavior from aerial to cutaneous. We hypothesized that this behavioral change is caused by alterations in the neuronal circuit during both development and conditioning. We focused our study on whether the synaptic connection between RPeD1 and RPA6 neurons is modulated during development and conditioning. Our findings indicated that the RPeD1 has an excitatory monosynaptic contact with the RPA6 in young naive and operantly-conditioned adult animals. The relationship of this contact was well correlated with their respiratory behavior.
Karasawa
T
T
Graduate School of High-Technology for Human Welfare, Tokai University, 317 Nishino, Numazu 410-0321, Shizuoka, Japan.
Sato
Nao
N
Horikoshi
T
T
Sakakibara
M
M
D000818:Animals; D003216:Conditioning, Operant / Q000502:physiology; D017952:Ganglia, Invertebrate / Q000254:growth & development / Q000502:physiology; D008195:Lymnaea / Q000254:growth & development* / Q000502:physiology*; D009046:Motor Neurons / Q000502:physiology; D012119:Respiration; D013569:Synapses / Q000502:physiology