[Cord blood collection for potential stem cell transplantation to a family member: the long-term experience of a level-III maternity unit].
BACKGROUND
Cord blood transplantation is used to treat patients with malignant and nonmalignant hematopoietic diseases. This study assessed the feasibility of collecting cord blood for eventual transplantation to a sibling with such a disease.


METHODS
We studied the records of 47 infants from whom cord blood was collected for siblings from 1993 through 1999.


RESULTS
During the study, cord blood was collected for 47 potential recipients: 37 (80.4%) with malignant disease and 9 (19.6%) with nonmalignant disease. Delivery was induced before 39 weeks of gestation. The mean volume collected was 107+/-39 mL and the number of nucleated cells was 11.52 x 10(8). Problems making collection difficult included: impossibility of collecting cord blood because of spontaneous delivery (n=1), the cytomegalovirus-positive serologic status of donor (n=7), and an inadequate number of nucleated cells (n=16). Weekday collection was possible for 60% of the donors. To date, only 7 of these cord blood collections have been used for stem cell transplantations.


CONCLUSIONS
This retrospective study demonstrates the practical difficulties in collecting cord blood for transplantation to siblings, difficulties that may decrease the likelihood of success.
Gascard
Cécile
C
Clinique d'obstétrique, Hôpital Jeanne de Flandre, F-59037 Lille Cedex, France.
Boulanger
Florence
F
Lambiliotte
Anne
A
Depret
Sandrine
S
Nelken
Brigitte
B
Royez-Brovelli
Muriel
M
Mazingue
Françoise
F
Jouet
Jean Pierre
JP
Subtil
Damien
D
D000293:Adolescent; D000328:Adult; D001800:Blood Specimen Collection; D002648:Child; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation; D005192:Family Health; D005240:Feasibility Studies; D005312:Fetal Blood; D006402:Hematologic Diseases / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult