A convenient route to [68Ga]Ga-MAA for use as a particulate PET perfusion tracer.
A convenient method is described for compounding [(68)Ga]Ga-MAA (MAA=macroaggregated human serum albumin) with the eluate of a commercially available TiO(2)-based (68)Ge/(68)Ga generator. The final [(68)Ga]Ga-MAA product was obtained with an 81.6+/-5.3% decay-corrected radiochemical yield and a radiochemical purity of 99.8+/-0.1% (n=5). Microscopic examination showed the [(68)Ga]Ga-MAA product to remain within the original particle size range. The entire procedure, from generator elution to delivery of the final [(68)Ga]Ga-MAA suspension, could be completed in 25 min. Only 4.4+/-0.9% of the total (68)Ge breakthrough remaining associated with the final [(68)Ga]Ga-MAA product. The procedure allows reasonably convenient preparation of [(68)Ga]Ga-MAA in a fashion that can be readily adapted to sterile product compounding for human use.
Mathias
Carla J
CJ
Department of Industrial and Physical Pharmacy, Division of Nuclear Pharmacy, Purdue University, West Lafayette, IN 47907-2091, USA.
Green
Mark A
MA
D007553:Isotope Labeling / Q000379:methods; D009942:Organometallic Compounds / Q000737:chemistry* / Q000302:isolation & purification*; D010477:Perfusion / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000737:chemistry*; D012709:Serum Albumin / Q000737:chemistry* / Q000302:isolation & purification*
D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D012709:Serum Albumin; C059652:gallium macroaggregated human serum albumin