An introduction to molecular targeted therapy of cancer.
The rapidly advancing elucidation of molecular targets in human cancers during the last decade has provided an excellent basis for the development of novel therapeutics. A huge variety of potential target structures have been identified, many of which are already being exploited for therapeutic purposes. This review introduces the reader into the concept of molecular targeted therapies, and provides some prototypic examples.
Allgayer
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Department of Experimental Surgery, Joint Unit Molecular Oncology of Solid Tumors, DKFZ (German Cancer Research Center) Heidelberg, Mannheim Medical Faculty, Ruprecht Karls University Heidelberg, Germany. heike.allgayer@chir.ma.uni-heidelberg.de
Fulda
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D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors*; D009369:Neoplasms / Q000628:therapy*
D000970:Antineoplastic Agents; D009363:Neoplasm Proteins