title: The expression of MMP-2, MMP-7, MMP-9, and TIMP-1 in chronic rhinosinusitis and nasal polyposis.
abstract: OBJECTIVE
  To investigate the expression and clinical significance of MMP-2, MMP-7, MMP-9, and TIMP-1 in patients with nasal polyposis (NP) and chronic rhinosinusitis (CRS).
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  This study involved 54 patients. There were three groups: nasal polyposis group, chronic rhinosinusitis group, and control group. Specimens were collected during endoscopic sinus surgery. Each sample was immunohistochemically examined.
  
  
  RESULTS
  Expression of MMP-2 was found significantly increased in NP, whereas MMP-7 expression was found significantly increased in CRS (P < 0.001). TIMP-1 was significantly high in control group compared to CRS and NP (P < 0.001 and P = 0.002, respectively).
  
  
  CONCLUSIONS
  Different regulation type of activation of MMPs has been found in these two diseases. If MMP-2 expression is intense in the mucosa, then this ends with polyp formation; if MMP-7 expression is intense, it ends with CRS or stays as CRS.
authors.affiliation: ENT Clinic, Ministry of Health Ankara Education and Training Hospital, Ankara, Turkey. haberalcan@gmail.com <haberalcan@gmail.com>
authors.forename: Ilknur Haberal
authors.initials: IH
authors.lastname: Can
authors.forename: Kursat
authors.initials: K
authors.lastname: Ceylan
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Caydere
authors.forename: Ethem Erdal
authors.initials: EE
authors.lastname: Samim
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ustun
authors.forename: Durdu Sertkaya
authors.initials: DS
authors.lastname: Karasoy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020783:Matrix Metalloproteinase 7 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D009298:Nasal Polyps / Q000201:enzymology*; D011446:Prospective Studies; D012852:Sinusitis / Q000201:enzymology*; D018709:Statistics, Nonparametric; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism*
chemical_list: D019715:Tissue Inhibitor of Metalloproteinase-1; D020783:Matrix Metalloproteinase 7; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9