title: Models of the pulsatile hydrodynamics of cerebrospinal fluid flow in the normal and abnormal intracranial system.
abstract: Images obtained from magnetic resonance imaging have helped to ascertain that both the cerebrospinal fluid (CSF) and brain move in a pulsatile manner within the cranium. However, these images are not able to reveal any quantitative information on the physiological forces that are associated with pulsatile motion. Understanding both the pressure and velocity flow field of CSF in the ventricles is important to help understand the mechanics of hydrocephalus. Four separate fluid structure interaction models of the ventricular system in the sagittal plane were created for this purpose. The first model was of a normal brain. The second and third models were pathological brain models with aqueductal stenosis at various locations along the fluid pathway. The fourth model was of a hydrocephalic brain. Results revealed the hydrodynamics of CSF pulsatile flow in the ventricles of these models. Most importantly, it has also revealed the different changes in CSF pulsatile hydrodynamics caused by the various locations of fluid flow obstructions.
authors.affiliation: Prince of Wales Medical Research Institute, University of New South Wales, Randwick, Australia. enquiries_cheng@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Cheng
authors.forename: E
authors.initials: E
authors.lastname: Jacobson
authors.forename: L E
authors.initials: LE
authors.lastname: Bilston
mesh_terms: D002552:Cerebral Ventricles / Q000503:physiopathology*; D002555:Cerebrospinal Fluid; D003198:Computer Simulation; D006801:Humans; D006849:Hydrocephalus / Q000503:physiopathology*; D007427:Intracranial Pressure; D008954:Models, Biological; D011673:Pulsatile Flow; D012212:Rheology / Q000379:methods