title: Population dynamics in vasopressin cells.
abstract: Most neurons sense and code change, and when presented with a constant stimulus they adapt, so as to be able to detect a fresh change. However, for some things it is important to know their absolute level; to encode such information, neurons must sustain their response to an unchanging stimulus while remaining able to respond to a change in that stimulus. One system that encodes the absolute level of a stimulus is the vasopressin system, which generates a hormonal signal that is proportional to plasma osmolality. Vasopressin cells sense plasma osmolality and secrete appropriate levels of vasopressin from the neurohypophysis as needed to control water excretion; this requires sustained secretion under basal conditions and the ability to increase (or decrease) secretion should plasma osmolality change. Here we explore the mechanisms that enable vasopressin cells to fulfill this function, and consider how coordination between the cells might distribute the secretory load across the population of vasopressin cells.
authors.affiliation: Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK. gareth.leng@ed.ac.uk
authors.forename: Gareth
authors.initials: G
authors.lastname: Leng
authors.forename: Colin
authors.initials: C
authors.lastname: Brown
authors.forename: Nancy
authors.initials: N
authors.lastname: Sabatier
authors.forename: Victoria
authors.initials: V
authors.lastname: Scott
mesh_terms: D000818:Animals; D019898:Autocrine Communication / Q000502:physiology; D002477:Cells / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism* / Q000502:physiology*; D009994:Osmolar Concentration; D019899:Paracrine Communication / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014667:Vasopressins / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D014667:Vasopressins