title: Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer.
abstract: A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible "cage" that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.
authors.affiliation: Center for Chemical Dynamics and Nanomaterials Research, Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cheng
authors.forename: Anna
authors.initials: A
authors.lastname: C Samia
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Meyers
authors.forename: Irene
authors.initials: I
authors.lastname: Panagopoulos
authors.forename: Baowei
authors.initials: B
authors.lastname: Fei
authors.forename: Clemens
authors.initials: C
authors.lastname: Burda
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D006046:Gold / Q000737:chemistry*; D007211:Indoles / Q000008:administration & dosage* / Q000737:chemistry; D054833:Isoindoles; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D011092:Polyethylene Glycols / Q000737:chemistry; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry; D026082:Singlet Oxygen / Q000032:analysis; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D007211:Indoles; D054833:Isoindoles; D011838:Radiation-Sensitizing Agents; D026082:Singlet Oxygen; D011092:Polyethylene Glycols; D006046:Gold; C013647:phthalocyanine