Larrea divaricata Cav (Jarilla): production of superoxide anion, hydrogen peroxide and expression of zymosan receptors.
Larrea divaricata is a plant widely used in folk medicine in Argentina. This work aimed to study the mechanisms of decoction activity on the release of oxygen reactive species. Decoction increased the binding of zymosan-FITC and superoxide production. Cadmium decreased the superoxide production as well as malonate and barbital. Decoction decreased the release of hydrogen peroxide. Decoction increased the reduction of MTT but not when malonate and barbital were included. Together, decoction increased the expression of dectin-1 leading to increased superoxide production. It is possible that decoction increases the activity of peroxidase, and decreases the Cu, Zn-superoxide dismutase.
Davicino
Roberto
R
Department of Biochemistry and Biological Sciences, Microbiology Area, Faculty Chemistry, Biochemistry and Pharmacy, National University of San Luis, Chacabuco and Pedernera, San Luis, Argentine.
Martinez
Carolina
C
Mattar
M Aída
MA
Casali
Yolanda
Y
Correa
Silvia G
SG
Aragon
Leslie
L
Saidman
Elbio Antonio
EA
Messina
German
G
Micalizzi
Blas
B
D000818:Animals; D001462:Barbital / Q000494:pharmacology; D019256:Cadmium Chloride / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005260:Female; D006861:Hydrogen Peroxide / Q000378:metabolism*; D032442:Larrea / Q000737:chemistry; D037181:Lectins, C-Type; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008314:Malonates / Q000494:pharmacology; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000494:pharmacology*; D011951:Receptors, Complement / Q000187:drug effects* / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*; D015054:Zymosan / Q000378:metabolism; D000099181:Dectin-1
D001462:Barbital; D019256:Cadmium Chloride; D006861:Hydrogen Peroxide; D037181:Lectins, C-Type; D008314:Malonates; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D010936:Plant Extracts; D011951:Receptors, Complement; D013481:Superoxides; D015054:Zymosan; D000099181:Dectin-1; C048084:zymosan receptor; C030290:malonic acid