title: Early results of magnetic resonance-guided focused ultrasound surgery of adenomyosis: analysis of 20 cases.
abstract: OBJECTIVE
  To evaluate the thermal ablative effects of magnetic resonance-(MR) guided focused ultrasound surgery (MRgFUS) on adenomyosis and to assess improvement in clinical parameters.
  
  
  METHODS
  Twenty patients with adenomyosis were treated with MRgFUS. Extensive adenomyosis (6 cases) was treated with 2 applications. Uterine volume was evaluated by MR imaging before and immediately after MRgFUS. Ablation of adenomyosis and the architecture of nonperfused areas were evaluated immediately after MRgFUS. Improvement in patient symptoms was assessed through the symptom severity score questionnaire (Canadian Task Force classification II-3).
  
  
  METHODS
  Department of gynecology at a Japanese general hospital.
  
  
  METHODS
  Premenopausal women at least 18 years of age with symptomatic adenomyosis.
  
  
  METHODS
  Thermal ablation by MRgFUS.
  
  
  RESULTS
  We classified the nonperfused lesions on contrast-enhanced MR images immediately after MRgFUS into 3 types: lesions with round margins (type R), serrated margins (type S), and honeycomb architecture (type H). Type R was the most common (16/20 patients). Most adenomyosis lesions could be sufficiently ablated close to the serosal surface or to the endometrium by MRgFUS. The mean uterine volume 6 months after therapy was decreased by 12.7%. Symptom severity score improved significantly during 6 months of follow-up. No serious complications were observed.
  
  
  CONCLUSIONS
  These early results indicate the safe and effective ablation of adenomyosis tissue by MRgFUS. The procedure also resulted in the improvement in clinical symptoms during the 6 months of follow-up.
authors.affiliation: Department of Gynecology, Shinsuma General Hospital, and Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan. fukunish@iris.eonet.ne.jp
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Fukunishi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Funaki
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Sawada
authors.forename: Kayo
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Maeda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kaji
mesh_terms: D018194:Adenomyoma / Q000000981:diagnostic imaging / Q000628:therapy*; D000328:Adult; D004715:Endometriosis / Q000000981:diagnostic imaging / Q000628:therapy; D005260:Female; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D012720:Severity of Illness Index; D014464:Ultrasonic Therapy / Q000379:methods*; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*