title: Squalamine: an appropriate strategy against the emergence of multidrug resistant gram-negative bacteria?
abstract: We reported that squalamine is a membrane-active molecule that targets the membrane integrity as demonstrated by the ATP release and dye entry. In this context, its activity may depend on the membrane lipid composition. This molecule shows a preserved activity against bacterial pathogens presenting a noticeable multi-resistance phenotype against antibiotics such as polymyxin B. In this context and because of its structure, action and its relative insensitivity to efflux resistance mechanisms, we have demonstrated that squalamine appears as an alternate way to combat MDR pathogens and by pass the gap regarding the failure of new active antibacterial molecules.
authors.affiliation: UMR-MD1, Facultés de Médecine et de Pharmacie, Marseille, France.
authors.forename: Chanaz
authors.initials: C
authors.lastname: Salmi
authors.forename: Celine
authors.initials: C
authors.lastname: Loncle
authors.forename: Nicolas
authors.initials: N
authors.lastname: Vidal
authors.forename: Yves
authors.initials: Y
authors.lastname: Letourneux
authors.forename: Jacques
authors.initials: J
authors.lastname: Fantini
authors.forename: Marc
authors.initials: M
authors.lastname: Maresca
authors.forename: Nadira
authors.initials: N
authors.lastname: Taïeb
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Pagès
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Brunel
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D002777:Cholestanols / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple; D004926:Escherichia coli / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D008055:Lipids / Q000737:chemistry; D008856:Microscopy, Fluorescence / Q000379:methods; D008954:Models, Biological; D008956:Models, Chemical; D010539:Permeability; D010641:Phenotype; D011112:Polymyxin B / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002777:Cholestanols; D008055:Lipids; D000255:Adenosine Triphosphate; C079655:squalamine; D011112:Polymyxin B