25-Hydroxyvitamin D-1 alpha-hydroxylase (CYP27B1) is a new class of tumor suppressor in the prostate.
The active form of vitamin D, 1alpha,25-dihydroxyvitamin D (1alpha,25(OH)2D), inhibits proliferation and induces the differentiation of prostate cells in culture, attenuates tumor growth in animal models, and decreases prostate specific antigen (PSA) levels in prostate cancer patients. The enzymes that are responsible for the activation of vitamin D to 1alpha,25(OH)2D include vitamin D-25-hydroxylase (25-OHase) and 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-OHase or CYP27BJ) and are present in cultured prostate cells. The demonstration that a differential expression of 1alpha-OHase between noncarcinogenic and carcinogenic prostate cells and the ability of epidermal growth factor (EGF) to up-regulate 1alpha-OHase promoter activity in the noncarcinogenic, not the carcinogenic prostate cells suggested that a dysregulation of 1alpha-OHase in cancer cells may lead to the aberrant growth of prostate cancer cells. Thus, the 1alpha-OHase gene is a tumor suppressor gene responsible for the normal regulation of prostate cell growth.
Chen
Tai C
TC
Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA. taichen@bu.edu
D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000096:biosynthesis* / Q000235:genetics; D015870:Gene Expression; D016147:Genes, Tumor Suppressor; D006801:Humans; D020935:MAP Kinase Signaling System; D008297:Male; D011467:Prostate / Q000201:enzymology* / Q000473:pathology / Q000502:physiology; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology
D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase