title: Durable complete response to frontline docetaxel in an advanced prostate cancer patient with favourable CYP1B1 isoforms: suggestion for changing paradigms?
abstract: Docetaxel is currently indicated for androgen-independent, metastatic prostate cancer; there is also evidence demonstrating the role of CYP1B1 in modulating the activity of the drug. We present the case of a man with residual disease after radical prostatectomy treated successfully with docetaxel chemotherapy. After only two cycles of therapy, a complete remission was obtained and then consolidated with additional cycles of docetaxel and radiotherapy. Prospective genetic analysis had shown that the patient had a favourable CYP1B1 genotype. He has been disease free since August 2006. Prospective trials investigating this strategy are warranted.
authors.affiliation: Institute of Haematology and Medical Oncology L. e A. Seràgnoli, Policlinico Sant'Orsola Malpighi, University of Bologna, Via Massarenti 9, Bologna, Italy. giovanni.brandi@unibo.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Brandi
authors.forename: Francesco
authors.initials: F
authors.lastname: de Rosa
authors.forename: Romano
authors.initials: R
authors.lastname: Danesi
authors.forename: Gian Carlo
authors.initials: GC
authors.lastname: Montini
authors.forename: Guido
authors.initials: G
authors.lastname: Biasco
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D065633:Cytochrome P-450 CYP1B1; D018450:Disease Progression; D000077143:Docetaxel; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D012074:Remission Induction; D043823:Taxoids / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D007527:Isoenzymes; D043823:Taxoids; D000077143:Docetaxel; D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1