A New TRADDition in intracellular antiviral signaling.
To effectively defeat viral infection, a mammalian host must detect the presence of viruses and activate a robust antiviral response, which is mediated by cytokines known as type I interferons (IFNs). Much excitement has been generated by the discovery of the retinoic acid-induced gene 1-like helicase (RLH) pathway, which detects RNA-containing viruses in the cytoplasm and activates the type I IFN response. A study now describes a role for the tumor necrosis factor receptor (TNFR)-associated death domain (TRADD) in the antiviral response and sheds new light on how the RLH signaling complex is organized upon viral infection.
Pietras
Eric M
EM
Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.
Cheng
Genhong
G
D000818:Animals; D006801:Humans; D012328:RNA Viruses / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D053199:TNF Receptor-Associated Death Domain Protein / Q000502:physiology*; D014777:Virus Diseases / Q000517:prevention & control*
D053199:TNF Receptor-Associated Death Domain Protein