title: [Prenatal diagnostics of selected types of birth defects in the Czech Republic in 1994 - 2006 period].
abstract: OBJECTIVE
  To analyze an efficiency of prenatal diagnostics of selected types of birth defects in the Czech Republic in 1994 - 2006 period.
  
  
  METHODS
  A retrospective epidemiological study and a prenatal diagnostics efficiency analysis.
  
  
  METHODS
  Department of Medical Genetics, Thomayer's University Hospital, Prague. Chair of Medical Genetics, Postgraduate Medical Institute, Prague, Czech Republic.
  
  
  METHODS
  Data were collected from National Birth Defects Register (Institute of Health Information and Statistics). Incidences of selected types of birth defects were analyzed.
  
  
  RESULTS
  In 1994 - 2006, totally 1 132 567 children were born in the Czech Republic, out of which more than 42 000 with a birth defect. A mean incidence was 339 per 10 000 live births with a maximum of 414.58 per 10 000 in 2003. In the same time period, 6113 cases of birth defect prenatal diagnostics (493 per 10 000 live biths) were reported.
  
  
  CONCLUSIONS
  In a comparison of 1980 - 1993 and 1994 - 2006 periods, a significant increase of prenatal diagnostics efficiency was recorded.
authors.affiliation: Oddĕlení lékarské genetiky, Fakultní Thomayerova nemocnice, Praha. vladimir.gregor@ftn.cz
authors.forename: V
authors.initials: V
authors.lastname: Gregor
authors.forename: A
authors.initials: A
authors.lastname: Sípek
authors.forename: J
authors.initials: J
authors.lastname: Horácek
authors.forename: A
authors.initials: A
authors.lastname: Sípek
authors.forename: P
authors.initials: P
authors.lastname: Langhammer
mesh_terms: D000013:Congenital Abnormalities / Q000175:diagnosis* / Q000453:epidemiology; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D011247:Pregnancy; D011296:Prenatal Diagnosis