The relationship between coronary artery disease and uric acid levels in young patients with acute myocardial infarction.
BACKGROUND
Serum uric acid concentrations are higher in patients with established coronary artery disease than in healthy controls. This study aimed to determine the role of uric acid in predetermining coronary artery disease in young patients with acute myocardial infarction (AMI).


METHODS
This study included 80 of 1612 patients who applied our hospital between January 2000 and December 2005. All of the patients were under 35 years old, diagnosed with AMI by clinical and laboratory findings, and had coronary angiography. The study population was divided into two groups, the first having critical coronary artery disease (group I) and the second having normal coronary arteries (group II). Then we compared these groups with age, body mass index, risk factors, serum protein C, protein S, antithrombin III, creatinine and uric acid levels.


RESULTS
Myocardial infarction was located in 65% anterior, 15% inferior, 15% inferiolateral and 5% high lateral, respectively. Forty five % of patients had critical coronary artery disease (group I, n = 36) and 55% had normal coronary arteries (group II, n = 44). There were no differences in the two groups with regard to body mass index, family history, hypertension, smoking, cholesterol level, triglyceride level and creatinine level, lack of protein C, lack of protein S or lack of antithrombin III. Serum uric acid levels were found to be higher in group I (7.0 +/- 1.4 mg/dL) than in group II (4.9 +/- 1.1 mg/dL; p = 0.003).


CONCLUSIONS
This study showed that high serum uric acid levels were associated with critical coronary artery disease in young patients (< 35 years) with AMI.
Tatli
Ersan
E
Department of Cardiology, Trakya University School of Medicine, Edirne, Turkey. ersantatli@yahoo.com
Aktoz
Meryem
M
Buyuklu
Mutlu
M
Altun
Armagan
A
D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D015992:Body Mass Index; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000032:analysis; D014527:Uric Acid / Q000097:blood*
D011486:Protein C; D017293:Protein S; D014527:Uric Acid; D000990:Antithrombin III; D003404:Creatinine