title: Transplant-associated Ochroconis gallopava infections.
abstract: BACKGROUND
  Ochroconis gallopava is a neurotropic dematiaceous mold that causes respiratory and central nervous system (CNS) infection in domestic poultry and in immunocompromised patients. We recently treated 3 solid organ transplant (SOT) recipients for pulmonary Ochroconis infections with successful outcome, prompting us to review the literature on this unique pathogen.
  
  
  METHODS
  We reviewed all published cases of O. gallopava infections in SOT recipients and analyzed the impact of CNS infection on the outcome.
  
  
  RESULTS
  In addition to the 3 new cases reported here, 9 published cases of Ochroconis infection were analyzed. The disease involved the lungs only in 5/12 (42%) of patients, brain in 6/12 (50%) patients, and lung and skin in 1 patient. Survival was significantly reduced with brain infection (33% vs. 100%; P<0.03; Fisher's exact test).
  
  
  CONCLUSIONS
  O. gallopava may infect SOT recipients with a particular tropism for the CNS. Early recognition of O. gallopava pulmonary infection is important, as the prognosis is excellent before dissemination to the brain.
authors.affiliation: Section of Infectious Diseases, Washington Hospital Center, Washington, District of Columbia 20010, USA. Shmuel.Shoham@medstar.net
authors.forename: S
authors.initials: S
authors.lastname: Shoham
authors.forename: L
authors.initials: L
authors.lastname: Pic-Aluas
authors.forename: J
authors.initials: J
authors.lastname: Taylor
authors.forename: K
authors.initials: K
authors.lastname: Cortez
authors.forename: M G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: Y
authors.initials: Y
authors.lastname: Shea
authors.forename: T J
authors.initials: TJ
authors.lastname: Walsh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000494:pharmacology; D001203:Ascomycota / Q000187:drug effects / Q000302:isolation & purification*; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D020314:Central Nervous System Fungal Infections / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D002681:China / Q000453:epidemiology; D003881:Dermatomycoses / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009181:Mycoses / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D016377:Organ Transplantation / Q000009:adverse effects*; D011014:Pneumonia / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D011859:Radiography; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000935:Antifungal Agents