The metalloproteinase-disintegrin ADAM10 is exclusively expressed by type I muscle fibers.
ADAM10 (Kuzbanian) is a member of a recently discovered family of membrane-anchored metalloproteinases with a complex and conserved domain structure. In part, these metalloproteinases have been implicated in muscle formation. Herein the expression pattern of ADAM10 in human skeletal muscle was studied. ADAM10 was found to be present in human myoblasts and to be exclusively expressed in type I fibers, suggesting that it may be critical in muscle fiber differentiation.
Dehmel
Thomas
T
Department of Neurology, Heinrich Heine University, Moorenstrasse 5, Düsseldorf, Germany.
Goebel
Hans Hilmar
HH
Hartung
Hans-Peter
HP
Lehmann
Helmar
H
Wiendl
Heinz
H
Kieseier
Bernd C
BC
D051722:ADAM Proteins / Q000378:metabolism*; D000072197:ADAM10 Protein; D000251:Adenosine Triphosphatases / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D018657:Muscle Fibers, Slow-Twitch / Q000378:metabolism*; D018995:Myosin Heavy Chains / Q000378:metabolism
D008565:Membrane Proteins; D053829:Amyloid Precursor Protein Secretases; D051722:ADAM Proteins; D000072197:ADAM10 Protein; C491236:ADAM10 protein, human; D000251:Adenosine Triphosphatases; D018995:Myosin Heavy Chains