title: APOE epsilon4 is associated with postictal confusion in patients with medically refractory temporal lobe epilepsy.
abstract: This study examined the relationship between the APOE epsilon4 allele and postictal confusion in patients with medically intractable temporal lobe epilepsy (TLE). Patients with at least one epsilon4 allele (n=22) were three times more likely to exhibit postictal confusion (68%) than the 63 patients without epsilon4 (43%). These preliminary results demonstrate that APOE epsilon4 is associated with an increased risk of postictal confusion in patients with medically intractable TLE, suggesting possible dysfunction in neuronal recovery mechanisms.
authors.affiliation: Epilepsy Center, Department of Psychiatry and Psychology, Neurological Institute, Cleveland Clinic P57, 9500 Euclid Avenue, Cleveland, OH 44195, United States. smerzj@ccf.org
authors.forename: Jessica S
authors.initials: JS
authors.lastname: Chapin
authors.forename: Robyn M
authors.initials: RM
authors.lastname: Busch
authors.forename: Damir
authors.initials: D
authors.lastname: Janigro
authors.forename: Michelle
authors.initials: M
authors.lastname: Dougherty
authors.forename: Cristiane Q
authors.initials: CQ
authors.lastname: Tilelli
authors.forename: Tara T
authors.initials: TT
authors.lastname: Lineweaver
authors.forename: Richard I
authors.initials: RI
authors.lastname: Naugle
authors.forename: Ramon
authors.initials: R
authors.lastname: Diaz-Arrastia
authors.forename: Imad M
authors.initials: IM
authors.lastname: Najm
mesh_terms: D000328:Adult; D053327:Apolipoprotein E4 / Q000235:genetics*; D016009:Chi-Square Distribution; D003221:Confusion / Q000150:complications* / Q000235:genetics*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D053327:Apolipoprotein E4