title: Association analysis of thyroglobulin gene variants with carcass and meat quality traits in beef cattle.
abstract: Thyroid hormones play an important role in regulating the metabolism and can affect the homeostasis of fat deposition. The gene encoding thyroglobulin (TG), producing the precursor for thyroid hormones, has been proposed as a positional and functional candidate gene for a QTL with an effect on fat deposition. In the present study, we identified 6 novel SNPs at the 3' flanking region of the TG gene. The SNP marker association analysis indicated that the SNP markers G133C, G156A, C220T and A506C were significantly associated with marbling score (P<0.05, N=271). Animals with the new homozygote genotype had higher marbling scores than those with the other genotypes. Besides, the linkage disequilibrium analysis indicated that these 4 SNPs were completely linked (r2 = 1). Results of this study suggest that the TG-gene-specific SNP may be a useful marker for meat quality traits in future marker-assisted selection programmes in beef cattle.
authors.affiliation: College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, China.
authors.forename: Qian-Fu
authors.initials: QF
authors.lastname: Gan
authors.forename: Lu-Pei
authors.initials: LP
authors.lastname: Zhang
authors.forename: Jun-Ya
authors.initials: JY
authors.lastname: Li
authors.forename: Guan-Yu
authors.initials: GY
authors.lastname: Hou
authors.forename: Heng-De
authors.initials: HD
authors.lastname: Li
authors.forename: Xue
authors.initials: X
authors.lastname: Gao
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Ren
authors.forename: Jin-Bao
authors.initials: JB
authors.lastname: Chen
authors.forename: Shang-Zhong
authors.initials: SZ
authors.lastname: Xu
mesh_terms: D000273:Adipose Tissue / Q000502:physiology*; D000818:Animals; D001823:Body Composition / Q000502:physiology*; D002417:Cattle / Q000033:anatomy & histology / Q000235:genetics* / Q000254:growth & development; D002874:Chromosome Mapping; D005260:Female; D005819:Genetic Markers; D015810:Linkage Disequilibrium; D008297:Male; D008460:Meat / Q000592:standards*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D040641:Quantitative Trait Loci; D013954:Thyroglobulin / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D013954:Thyroglobulin