Circulating endothelial cells and circulating endothelial progenitors in kidney disease--victims, witnesses, or accomplices?
Nephrologists deal with a host of pathologic conditions involving renal and systemic endothelium. Both in native and transplanted kidneys, often the insult to the renal endothelium initiates the pathogenic process ultimately leading to the loss of organ function. Also, systemic atherosclerosis is accelerated in patients with renal dysfunction. In this review we would like to cover the possible role of CECs and their counterparts--circulating EPCs in the pathogenesis of endothelial dysfunction associated with chronic renal failure, ANCA-associated vasculitis, and progression of chronic renal disease.
Závada
J
J
Department of Nephrology, First Faculty of Medicine and General Teaching Hospital, Charles University in Prague, Prague, Czech Republic. jzavada@centrum.cz
Kideryová
L
L
Pytlík
R
R
Tesar
V
V
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood / Q000276:immunology; D015415:Biomarkers; D002452:Cell Count; D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology*; D016030:Kidney Transplantation / Q000473:pathology; D013234:Stem Cells / Q000502:physiology*; D014657:Vasculitis / Q000209:etiology / Q000473:pathology
D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers