title: [High-titer idiopathic acquired factor V inhibitor patient showing decreased activities of multiple coagulation factors].
abstract: A 72-year-old male presented with oral bleeding resulting from acquired factor V (FV) inhibitor. We observed abnormalities in prothrombin time (PT) (8%) and activated partial thromboplastin time (APTT) (>200 seconds). FV activity was less than 3%, and a mixing test did not correlate with PT. FV inhibitor assay demonstrated 240 Bethesda units/ml. The patient also showed markedly decreased activity of Factors II (13%) and X (14%). Oral bleeding disappeared and coagulation abnormalities improved with prednisolone therapy. High titer FV inhibitor might affect coagulation assays even in a patient with normal factor activity.
authors.affiliation: Department of Hematology, Nagano Red Cross Hospital.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Shimizu
authors.forename: Naoaki
authors.initials: N
authors.lastname: Ichikawa
authors.forename: Mihoko
authors.initials: M
authors.lastname: Yotsumoto
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sumi
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ueno
authors.forename: Hikaru
authors.initials: H
authors.lastname: Kobayashi
mesh_terms: D000368:Aged; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D005165:Factor V / Q000037:antagonists & inhibitors*; D006470:Hemorrhage / Q000097:blood* / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D009059:Mouth Diseases / Q000097:blood* / Q000188:drug therapy* / Q000209:etiology; D009061:Mouth Mucosa; D011239:Prednisolone / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D019774:Blood Coagulation Factor Inhibitors; D005165:Factor V; D011239:Prednisolone