title: Dynamic HPLC of stereolabile iron(II) complexes on chiral stationary phases.
abstract: A series of chiral tris-(1,10)-phenanthroline iron(II) complexes have been resolved by HPLC on chiral stationary phases based on either cellulose tris-(3,5-dimethylphenylcarbamate) or teicoplanin. At sub ambient temperatures, baseline separation of the enantiomers was observed for five different iron(II) complexes featuring substituted phenanthroline ligands. Dynamic HPLC profiles were observed near or above room temperature, indicating on-column Delta/Lambda enantiomerization. Rate constants for the Delta/Lambda interconversion in free solution and during chromatography were obtained by thermal racemization experiments and by computer simulation of the HPLC dynamic plots, respectively.
authors.affiliation: Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università di Roma La Sapienza, 00185 Roma, Italy. claudio.villani@uniroma1.it
authors.forename: Claudio
authors.initials: C
authors.lastname: Villani
authors.forename: Francesco
authors.initials: F
authors.lastname: Gasparrini
authors.forename: Marco
authors.initials: M
authors.lastname: Pierini
authors.forename: Stefano Levi
authors.initials: SL
authors.lastname: Mortera
authors.forename: Ilaria
authors.initials: I
authors.lastname: D'Acquarica
authors.forename: Alessia
authors.initials: A
authors.lastname: Ciogli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Zappia