Cdc14B and APC/C tackle DNA damage.
Mitotic exit in budding yeast is regulated by the proteins Cdc14, APC/C(Cdh1), and Plk1. In this issue, Bassermann and colleagues (2008) show that this network of proteins has been rewired in human cells to control the cell cycle in response to DNA damage.
De Wulf
Peter
P
Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, Via Adamello 16, 20139 Milan, Italy.
Visintin
Rosella
R
D064173:Anaphase-Promoting Complex-Cyclosome; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism*; D004249:DNA Damage; D054637:Dual-Specificity Phosphatases / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*
D018797:Cell Cycle Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; C474200:CDC14B protein, human; D054637:Dual-Specificity Phosphatases