Studies on hydrazone derivatives as antifungal agents.
The increasing clinical importance of drug-resistant fungal pathogens has urged additional need to fungal research and new antifungal compound development. For this purpose, some N-(1-benzyl-2-phenylethylidene)-N'-[4-(aryl)thiazol-2-yl]hydrazone (1a-e) and N-(1-phenylbutylidene)-N'-[4-(aryl)thiazol-2-yl]hydrazone (2a-e) derivatives were synthesised and evaluated for antifungal activity. Their antifungal activities against standard and clinical strands of Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, Candida zeylanoides, and Candida parapsilosis were investigated. A significant level of activity was observed.
Ozdemir
Ahmet
A
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Eskisehir, Turkey. ahmeto@anadolu.edu.tr
Turan-Zitouni
Gulhan
G
Kaplancikli
Zafer Asim
ZA
Demirci
Fatih
F
Iscan
Gokalp
G
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D025141:Drug Resistance, Fungal; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology*
D000935:Antifungal Agents; D006835:Hydrazones