title: Short-term clinical exposure evaluation of a third-generation electrically heated cigarette smoking system (EHCSS) in adult smokers.
abstract: This randomized, controlled, forced-switching, open-label, parallel-group, single-center study in 100 male and female adult smokers evaluated 12 biomarkers of tobacco smoke exposure. We measured exposure to the following smoke constituents: nicotine, pyrene, tobacco-specific nitrosamines, three aromatic amines, carbon monoxide, benzene, acrolein, crotonaldehyde, and 1,3-butadiene. After baseline exposure determination, adult smokers of a conventional cigarette (CC) were switched to an electrically heated cigarette smoking system (EHCSS, Series K), continued smoking the CC, or stopped smoking (No-smoking) for 8 days in a controlled, confined, clinical setting. In the EHCSS group, the mean decrease from Baseline to Day 8 in the biomarkers of exposure ranged from 16% to 77% at Day 8 compared to Baseline. After adjusting for the residual effect (carryover effects due to long elimination half-life and non-tobacco confounding sources of exposure), the mean percent decrease from Baseline for all 12 biomarkers ranged from 47% to 90%. In conclusion, switching for 8 days from a conventional cigarette to the EHCSS substantially reduced exposure of adult smokers to several constituents of both the particulate and gas phases of cigarette smoke.
authors.affiliation: Philip Morris USA, Research Center, Clinical Evaluation, 4201 Commerce Road, Richmond, VA 23224, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Frost-Pineda
authors.forename: Barbara K
authors.initials: BK
authors.lastname: Zedler
authors.forename: Douglas
authors.initials: D
authors.lastname: Oliveri
authors.forename: Shixia
authors.initials: S
authors.lastname: Feng
authors.forename: Qiwei
authors.initials: Q
authors.lastname: Liang
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Roethig
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D004560:Electricity; D005260:Female; D006207:Half-Life; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008875:Middle Aged; D052638:Particulate Matter / Q000737:chemistry*; D012907:Smoking / Q000378:metabolism*; D013997:Time Factors; D014028:Tobacco Smoke Pollution / Q000032:analysis*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D052638:Particulate Matter; D014028:Tobacco Smoke Pollution