title: Management of incomplete remission and treatment resistance in first-episode psychosis.
abstract: BACKGROUND
  Incomplete remission and treatment resistance are common even in first-episode psychosis patients.
  
  
  OBJECTIVE
  The aim of this review was to provide an overview of the available interventions and treatment pathways for the management of incomplete remission and treatment resistance in first-episode psychosis.
  
  
  METHODS
  The review undertook a computerized and manual literature search for relevant articles published within recent years.
  
  
  RESULTS
  Standard therapy has to be optimized in order to prevent treatment non-response. The early detection strategies of incomplete remission and treatment resistance include re-evaluation of the diagnosis and optimization of pharmacological and non-pharmacological interventions including the treatment of co-morbid disorders. If partial or non-response is confirmed, pharmacological and psychosocial treatment adaptations should be applied stepwise as presented in the current review. Interventions have to be offered in a timely manner because early adaptation of treatment is associated with a greater probability of remission.
authors.affiliation: University Medical Centre Hamburg-Eppendorf, Psychosis Early Detection and Intervention Centre, Centre for Psychosocial Medicine, Department of Psychiatry and Psychotherapy, Martinistreet 52, D-20246 Hamburg, Germany. lambert@uke.uni-hamburg.de
authors.forename: Martin
authors.initials: M
authors.lastname: Lambert
authors.forename: Dieter
authors.initials: D
authors.lastname: Naber
authors.forename: Christian G
authors.initials: CG
authors.lastname: Huber
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D004351:Drug Resistance; D004565:Electroconvulsive Therapy; D006801:Humans; D011613:Psychotherapy; D011618:Psychotic Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology / Q000628:therapy; D012008:Recurrence; D012074:Remission Induction; D050781:Transcranial Magnetic Stimulation; D017211:Treatment Failure
chemical_list: D014150:Antipsychotic Agents