SCART scavenger receptors identify a novel subset of adult gammadelta T cells.
Although there has been great progress in the characterization of alphabeta T cell differentiation, selection, and function, gammadelta T cells have remained poorly understood. One of the main reasons for this is the lack of gammadelta T cell-specific surface markers other than the TCR chains themselves. In this study we describe two novel surface receptors, SCART1 and SCART2. SCARTs are related to CD5, CD6, and CD163 scavenger receptors but, unlike them, are found primarily on developing and mature gammadelta T cells. Characterization of SCART2 positive immature and peripheral gammadelta T cells suggests that they undergo lineage specification in the thymus and belong to a new IL-17-producing subset with distinct homing capabilities.
Kisielow
Jan
J
Molecular Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology (ETH), Zürich-Schlieren, Switzerland. jan.kisielow@env.ethz.ch
Kopf
Manfred
M
Karjalainen
Klaus
K
D000375:Aging / Q000276:immunology*; D000595:Amino Acid Sequence; D000818:Animals; D019070:Cell Lineage / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D002477:Cells / Q000276:immunology*; D002478:Cells, Cultured; D020405:Dermis / Q000166:cytology / Q000276:immunology; D015536:Down-Regulation; D020381:Interleukin-17 / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D010802:Phylogeny; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000145:classification / Q000276:immunology* / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D016415:Sequence Alignment; D015398:Signal Transduction / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D020381:Interleukin-17; D016692:Receptors, Antigen, T-Cell, gamma-delta; D011956:Receptors, Cell Surface; C530761:SCART1 protein, mouse; C530762:SCART2 protein, mouse