title: Carbimazole embryopathy-bilateral choanal atresia and patent vitello-intestinal duct: a case report and review of literature.
abstract: BACKGROUND
  In utero exposure to carbimazole for maternal hyperthyroidism has been reported to cause choanal atresia. There are case reports of patent vitello-intestinal duct and Meckel's diverticulum in similar association.
  
  
  METHODS
  We report another such instance of an infant who was exposed to carbimazole in utero, presenting with bilateral choanal atresia and patent vitello-intestinal duct.
  
  
  CONCLUSIONS
  As there seems to be no reports of a possible association between propylthiouracil and congenital malformations, it may be safer to use propylthiouracil instead of carbimazole.
authors.affiliation: Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Lakshminarayanan
authors.initials: L
authors.lastname: Kannan
authors.forename: Satish
authors.initials: S
authors.lastname: Mishra
authors.forename: Ramesh
authors.initials: R
authors.lastname: Agarwal
authors.forename: Venkat
authors.initials: V
authors.lastname: Kartikeyan
authors.forename: Neerja
authors.initials: N
authors.lastname: Gupta
authors.forename: Madhulika
authors.initials: M
authors.lastname: Kabra
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000196:embryology*; D013956:Antithyroid Agents / Q000009:adverse effects*; D002231:Carbimazole / Q000009:adverse effects*; D002754:Choanal Atresia / Q000139:chemically induced* / Q000196:embryology* / Q000601:surgery; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011247:Pregnancy; D014816:Vitelline Duct / Q000002:abnormalities* / Q000196:embryology
chemical_list: D013956:Antithyroid Agents; D002231:Carbimazole