title: Protection studies against Marek's disease using baculovirus-expressed glycoproteins B and C of Marek's disease virus type 1.
abstract: Glycoproteins B (MDV1-gB) and C (MDV1-gC) of Marek's disease virus type 1 (MDV 1) expressed by baculovirus recombinants [rAcNPV(s)] were investigated for their ability to confer protective immunity in chickens against virulent MDV1 challenge. Immunization of chickens with rAcNPV-expressed MDV1-gB induced antibody against MDV1 and resulted in strong protection against the lethal challenge with MDV1. In contrast, immunization of chickens with rAcNPV-expressed MDV1-gC induced antibody against MDV1, but failed to protect against challenge with the virulent MDV1. Co-immunization with both rAcNPV-expressed MDV1-gB and MDV1-gC seemed to show no synergistic effect.
authors.affiliation: Department of Veterinary Microbiology, Faculty of Agriculture, University of Tokyo, Tokyo, 113, Japan.
authors.forename: H K
authors.initials: HK
authors.lastname: Jang
authors.forename: T
authors.initials: T
authors.lastname: Kitazawa
authors.forename: M
authors.initials: M
authors.lastname: Ono
authors.forename: Y
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: K
authors.initials: K
authors.lastname: Maeda
authors.forename: N
authors.initials: N
authors.lastname: Yokoyama
authors.forename: Y
authors.initials: Y
authors.lastname: Tohya
authors.forename: M
authors.initials: M
authors.lastname: Niikura
authors.forename: T
authors.initials: T
authors.lastname: Mikami