title: Nociceptin/orphanin FQ peptide receptor as a therapeutic target for obesity.
abstract: Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a candidate target for novel therapeutics for a range of conditions, including obesity. This article reviews recent advances in understanding of N/OFQ's involvement in the regulation of food intake and appraises current developments in the rational design of antagonists aimed at the NOP receptor.
authors.affiliation: Department of Pharmacology, Tennis Court Road, University of Cambridge, Cambridge, CB2 1PD UK.
authors.forename: Magdalena J
authors.initials: MJ
authors.lastname: Przydzial
authors.forename: Lora K
authors.initials: LK
authors.lastname: Heisler
mesh_terms: D000818:Animals; D015195:Drug Design; D005502:Food; D006801:Humans; D008024:Ligands; D009292:Narcotic Antagonists; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D000094942:Nociceptin Receptor
chemical_list: D008024:Ligands; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D000094942:Nociceptin Receptor; C000722283:OPRL1 protein, human