title: Synthesis of amides of 2,4-dioxothiazolidin-5-yl acetic acid with 1,2,4-triazole substituents.
abstract: In the reaction of (2,4-dioxothiazolidin-5-yl)acetyl chloride with 1,2,4-triazole, 4-phenyl-1,2,4-triazolin-5-one and 4-phenyl-1,2,4-triazolin-5-thione, the new corresponding amides (2-4) were obtained. For compounds 2 and 4 effects on central nervous system (CNS) of mice were studied.
authors.affiliation: Department of Organic Chemistry, Medical University, 6 Staszica Str., 20-081 Lublin, Poland. nazar.trotsko@am.lublin.pl
authors.forename: Nazar
authors.initials: N
authors.lastname: Trotsko
authors.forename: Maria
authors.initials: M
authors.lastname: Dobosz
authors.forename: Anna
authors.initials: A
authors.lastname: Chodkowska
authors.forename: Ewa
authors.initials: E
authors.lastname: Jagiełło-Wójtowicz
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D053778:Thiazolidines / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000577:Amides; D002491:Central Nervous System Agents; D053778:Thiazolidines; D014230:Triazoles