title: Impact of the introduction of pneumococcal conjugate vaccine on rates of community acquired pneumonia in children and adults.
abstract: Pneumococcal conjugate vaccine use among young children has led to significant declines in invasive pneumococcal disease in the United States, but the impact on community-acquired pneumonia is unknown. We conducted population-based pneumonia surveillance among 794,282 Group Health members before and after infant vaccine introduction in 2000. We presumptively identified pneumonia episodes using diagnosis codes assigned to medical encounters and confirmed 17,513 outpatient and 6318 hospitalized events by reviewing chest radiograph reports or hospitalization records. There was evidence for a decline in rates of both outpatient and hospitalized pneumonia in children less than 1 year of age following vaccine introduction but there were no consistent reductions in pneumonia rates among older children and adults.
authors.affiliation: Group Health Center for Health Studies, Seattle, WA, United States. nelson.jl@ghc.org
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Nelson
authors.forename: Michael
authors.initials: M
authors.lastname: Jackson
authors.forename: Onchee
authors.initials: O
authors.lastname: Yu
authors.forename: Cynthia G
authors.initials: CG
authors.lastname: Whitney
authors.forename: Lora
authors.initials: L
authors.lastname: Bounds
authors.forename: Rachel
authors.initials: R
authors.lastname: Bittner
authors.forename: Ann
authors.initials: A
authors.lastname: Zavitkovsky
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Jackson
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*; D003710:Demography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines; D011014:Pneumonia / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*; D011159:Population Surveillance; D015995:Prevalence; D012189:Retrospective Studies; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D018074:Vaccines, Conjugate
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate