title: Rational design and synthesis of 2,2-bisheterocycle tandem derivatives as non-nucleoside hepatitis B virus inhibitors.
authors.affiliation: Chinese National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, 189 Guo Shou Jing Road, Shanghai 201203, China. fjnan@mail.shcnc.ac.cn
authors.forename: Hai-Jun
authors.initials: HJ
authors.lastname: Chen
authors.forename: Wen-Long
authors.initials: WL
authors.lastname: Wang
authors.forename: Gui-Feng
authors.initials: GF
authors.lastname: Wang
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Shi
authors.forename: Min
authors.initials: M
authors.lastname: Gu
authors.forename: Yu-Dan
authors.initials: YD
authors.lastname: Ren
authors.forename: Li-Fei
authors.initials: LF
authors.lastname: Hou
authors.forename: Pei-Lan
authors.initials: PL
authors.lastname: He
authors.forename: Feng-Hua
authors.initials: FH
authors.lastname: Zhu
authors.forename: Xian-Gen
authors.initials: XG
authors.lastname: Zhong
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Zuo
authors.forename: Fa-Jun
authors.initials: FJ
authors.lastname: Nan
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006515:Hepatitis B virus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D054852:Small Molecule Libraries; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017361:Viral Nonstructural Proteins / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D054852:Small Molecule Libraries; D013844:Thiazoles; D017361:Viral Nonstructural Proteins