Inhibition of mitochondrial fragmentation during sake brewing causes high malate production in sake yeast.
We previously demonstrated the presence and fragmentation of mitochondria during alcohol fermentation. Here, we show that Fis1p induces mitochondrial fragmentation, and inhibition of mitochondrial fragmentation causes higher malate production during sake brewing. These findings indicate that mitochondrial morphology affects the metabolism of constituents, providing a breeding strategy for high-malate-producing yeasts.
Kitagaki
Hiroshi
H
National Research Institute of Brewing, Higashi-hiroshima City, Hiroshima, Japan. kitagaki@nrib.go.jp
Kato
Taku
T
Isogai
Atsuko
A
Mikami
Shigeaki
S
Shimoi
Hitoshi
H
D008293:Malates / Q000378:metabolism*; D008928:Mitochondria / Q000502:physiology* / Q000648:ultrastructure*; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D014920:Wine / Q000032:analysis* / Q000382:microbiology*
D008293:Malates; C030298:malic acid