title: Long-term results of guided tissue regeneration therapy with non-resorbable and bioabsorbable barriers. IV. A case series of infrabony defects after 10 years.
abstract: BACKGROUND
  A 10-year follow-up study was conducted to clinically evaluate the long-term results after guided tissue regeneration (GTR) therapy of infrabony defects using non-resorbable and bioabsorbable barriers.
  
  
  METHODS
  Twelve pairs of contralateral infrabony defects were treated in 12 subjects with advanced periodontitis. Within each subject, one defect received a non-resorbable barrier and the other received a bioabsorbable barrier by random assignment. Clinical parameters were obtained at baseline and at 12 and 120+/-6 months after surgery.
  
  
  RESULTS
  Eight of 12 subjects were available for the examination at 120+/-6 months. Twelve and 120+/-6 months after GTR therapy statistically significant (P<0.05) vertical clinical attachment level (CAL-V) gain was observed in both groups (3.4+/-1.0 mm and 1.5+/-1.2 mm for the control group at 12 and 120 months, respectively, and 3.3+/-1.6 mm and 3.5+/-2.5 mm for the test group at 12 and 120 months, respectively). However, 120+/-6 months after GTR therapy, three infrabony defects (two controls and one test) had lost >2 mm of the attachment that had been gained 12 months after GTR therapy, and a statistically significant mean CAL-V loss of 1.7+/-1.3 mm was observed from 12 to 120+/-6 months in the control group. One tooth in the control group was lost between 60 and 120+/-6 months. The case series failed to show statistically significant differences between test and control regarding CAL-V gain 120+/-6 months after surgery.
  
  
  CONCLUSIONS
  CAL-V gain achieved 12 months after GTR therapy in infrabony defects using non-resorbable and bioabsorbable barriers was stable after 10 years in 12 of 16 defects.
authors.affiliation: Section of Periodontology, Department of Conservative Dentistry, Clinic for Oral, Dental, and Maxillofacial Diseases, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Pretzl
authors.forename: Ti-Sun
authors.initials: TS
authors.lastname: Kim
authors.forename: Rolf
authors.initials: R
authors.lastname: Holle
authors.forename: Peter
authors.initials: P
authors.lastname: Eickholz
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery*; D001672:Biocompatible Materials; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery; D010518:Periodontitis / Q000601:surgery; D011098:Polyglactin 910; D011138:Polytetrafluoroethylene; D012008:Recurrence; D016388:Tooth Loss / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011098:Polyglactin 910; D011138:Polytetrafluoroethylene