[Influence of progesterone receptors deficit in early stage of development on formation of the reproduction functions of female rats].
The effects of 100 mg/kg mifepristone administration from 1 to 5 postnatal days on formation of the female reproduction functions were studied. It has been shown that neonatal blockade of progesterone receptors resulted in significant decline of morphometric parameters of the adult rat uterus, as well as disturbance sex steroids secretion and decrease density of uterus progesterone receptors in the oestrus. Neonatal administration of mifepristone did not change the rat ability to reproduction in favorable condition, but induced significant fetus resorption under the gestation pathology. These data suggest that violation of progesterone receptors mechanisms in neonatal period of life exert negative influence on the female reproduction functions in adult. We suggest, that neonatal treatment of mifepristone can been used as a model of progesterone receptors deficit in the adult rat uterus.
Ordian
N E
NE
Akulova
V K
VK
Mironova
V I
VI
Pivina
S G
SG
Rakitskaia
V V
VV
D000818:Animals; D005260:Female; D006727:Hormone Antagonists / Q000009:adverse effects* / Q000494:pharmacology; D015735:Mifepristone / Q000009:adverse effects* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011980:Receptors, Progesterone / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012098:Reproduction / Q000187:drug effects*; D014599:Uterus / Q000254:growth & development* / Q000473:pathology
D006727:Hormone Antagonists; D011980:Receptors, Progesterone; D015735:Mifepristone