title: [A study on toxicity of aquaculture drugs to luminescent bacteria].
abstract: OBJECTIVE
  To study the dose-response relation of the fish drugs and their joint toxicity on the luminescent bacteria.
  
  
  METHODS
  The single and joint toxicity of four kinds of fish drugs were inspected and evaluated by applying luminescent bacteria toxicity test. RESULTS; Four chemical componds were negatively correlated with luminescence and all correlation coefficient were greater than 0.99. From the dose response curve 50% effective concentration calculated for luminescent bacteria were 0.61 mg/L for Pb2+, 0.79 mg/L for Cu2+, 0.81 mg/L for furazolidone and 489.2 mg/L for chloramphenicol. K value of joint toxicity were 1.65 between Pb2+ and furazolidone, 1.09 between Pb2+ and chLoramphenicol and 1.58 between furazolidone and chloramphenicol.
  
  
  CONCLUSIONS
  Pb2+, Cu2+, furazolidone and chLoramphenicol inhibited bacterial luminescence under certain concentration. Pb2+ and furazolidone, Pb2+ and chloramphenicol, furazolidone and chloramphenicol showed an addition effect to luminescent bacteria.
authors.affiliation: MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.forename: Changhua
authors.initials: C
authors.lastname: Shi
authors.forename: Shuying
authors.initials: S
authors.lastname: Wu
authors.forename: Hongyan
authors.initials: H
authors.lastname: Liu
mesh_terms: D000818:Animals; D017756:Aquaculture / Q000379:methods*; D002701:Chloramphenicol / Q000494:pharmacology / Q000633:toxicity; D003300:Copper / Q000494:pharmacology / Q000633:toxicity; D005664:Furazolidone / Q000494:pharmacology / Q000633:toxicity; D007854:Lead / Q000494:pharmacology / Q000633:toxicity*; D049449:Luminescence; D010776:Photobacterium / Q000187:drug effects* / Q000254:growth & development; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical; D007854:Lead; D005664:Furazolidone; D002701:Chloramphenicol; D003300:Copper