title: Study of wound healing in rats treated with topical and injected mitomycin-C.
abstract: Experimental study in animals.
  
  
  BACKGROUND
  Mitomycin C has been used as a fibroblasts inhibitor, thus reducing the scaring process in surgical wounds.
  
  
  OBJECTIVE
  This paper aims at assessing the use of Mitomycin C to reduce the scaring process through its topical use and later injected reinforcements.
  
  
  METHODS
  We used a model of a creating a wound in the dorsum of rats, removing a circular piece of skin and letting it heal by itself. We used 18 rats, divided in three groups. The first group - Control, the second with topical use, and a third group with injected mitomycin C reinforcement, monthly for 2 months. After 3 months the animals were slaughtered and the scars were surgically removed and sent for histology study.
  
  
  RESULTS
  We noticed, under different criteria, that healing with topical mitomycin is less intense; however, when it was injected, the parameters were again comparable to those from the control group.
  
  
  CONCLUSIONS
  We believe that injected mitomycin C in the scar, since it is highly toxic, it destroys tissue and brings about scar neoformation.
  
  
  CONCLUSIONS
  Mitomycin C reduces the scaring process when used topically; however, it increases scar tissue formation when injected in these wounds.
authors.affiliation: Otorhinolaryngology Department, Faculdade de Ciências Médicas, Santa Casa de São Paulo, Brazil.
authors.forename: Fernando de Andrade
authors.initials: Fde A
authors.lastname: Quintanilha Ribeiro
authors.forename: Janaína de Pádua
authors.initials: Jde P
authors.lastname: Borges
authors.forename: Lusiele
authors.initials: L
authors.lastname: Guaraldo
authors.forename: Maria Regina
authors.initials: MR
authors.lastname: Vianna
mesh_terms: D000287:Administration, Topical; D000477:Alkylating Agents / Q000008:administration & dosage*; D000818:Animals; D005347:Fibroblasts / Q000187:drug effects*; D005355:Fibrosis / Q000517:prevention & control; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin