[Light-absorbing and antiradical properties of a product with lutein and zeaxanthin in vitro and kinetics of carotinoids at single oral administration on rats].
Light-absorbing and antiradical properties of the new product on a basis of lutein and zeaxanthin for correction of eye diseases in model system of initiated oxidation of isopropylbenzene were investigated. It is shown, that the product is the effective light-absorbing agent and inhibitor of free-radical oxidation in vitro. In experiments on animals (rat) the pharmacokinetics of the product was investigated at single oral administration. A simple, specific and sensitive RP-HPLC method for the determination of lutein in rat plasma was developed, which was applied to pharmacokinetic investigation in rats after oral administration of lutein at dose 20 mg/kg. It was established, that the peak plasma levels was achieved to 2 hour and the mean elimination half life was 2,4 hours.
Karlina
M V
MV
Pozharitskaia
O N
ON
Kosman
V M
VM
Shikov
A N
AN
Makarov
V G
VG
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004195:Disease Models, Animal; D005128:Eye Diseases / Q000097:blood / Q000188:drug therapy; D005609:Free Radicals / Q000037:antagonists & inhibitors* / Q000097:blood; D014975:Lutein / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013053:Spectrophotometry / Q000379:methods; D024341:Xanthophylls / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use; D065146:Zeaxanthins
D000975:Antioxidants; D005609:Free Radicals; D024341:Xanthophylls; D065146:Zeaxanthins; D014975:Lutein