Recoverable, soluble polymer-supported organic catalysts.
Enantioselective organic catalysis is currently the subject of an intense research activity aimed to develop 'metal-free' alternatives to established 'metal-based' catalytic processes. In the case of chiral catalysts, which are often expensive, or obtained after a complex synthesis, the immobilization on solid support represents an attractive methodology that allows the recovery and possibly the recycling of the catalytic species. Among the different solid matrixes employed, soluble polymers recently emerged as very convenient supports for the synthesis of a variety of small organic molecules, ligands and catalysts. This chapter highlights the more recent results obtained by our group in the field of poly(ethylene glycol) (PEG)-supported chiral and achiral organic catalysts. A few considerations on the methodologies, the future and the problems related to the immobilization of chiral organic catalysts are also briefly discussed.
Benaglia
M
M
Dipartimento di Chimica Organica e Industriale, Universita' degli Studi di Milano, Milan, Italy. maurizio.benaglia@unimi.it
D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D008956:Models, Chemical; D009930:Organic Chemicals / Q000138:chemical synthesis*; D009942:Organometallic Compounds / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011392:Proline / Q000737:chemistry; D012995:Solubility; D012997:Solvents / Q000737:chemistry
D009930:Organic Chemicals; D009942:Organometallic Compounds; D011108:Polymers; D012997:Solvents; D011392:Proline; D010100:Oxygen