title: Impact of obesity in mechanically ventilated patients: a prospective study.
abstract: OBJECTIVE
  To analyze the influence of severe obesity on mortality and morbidity in mechanically ventilated intensive care unit (ICU) patients.
  
  
  METHODS
  Prospective, multi-center exposed/unexposed matched epidemiologic study.
  
  
  METHODS
  Hospital setting.
  
  
  METHODS
  Severely obese patients (body mass index (BMI) >or= 35 kg/m(2)), mechanically ventilated for at least 2 days were matched with unexposed nonobese patients (BMI < 30 kg/m(2)) for center, gender, age (+/-5 years), and the simplified acute physiology (SAPS) II score (+/-5 points). We recorded tracheal intubation, catheter placement, nosocomial infections, development of pressure ulcers, ICU and hospital outcome.
  
  
  RESULTS
  Eighty-two severely obese patients (mean BMI, 42 +/- 6 kg/m(2)) were compared to 124 nonobese patients (mean BMI, 24 +/- 4 kg/m(2)). The ICU course was similar in both the groups, except for the difficulties during tracheal intubation (15 vs. 6%) and post-extubation stridor (15% vs. 3%), which were significantly more frequent in obese patients (P < 0.05). The ICU mortality rate did not differ between obese and nonobese patients (24 and 25%, respectively); nor did the risk-adjusted hospital mortality rate (0.76, 95% confidence interval 0.41-1.16 in obese patients versus 0.82, 95% confidence interval 0.54-1.13 in nonobese patients). Conditional logistic regression confirmed that mortality was not associated with obesity.
  
  
  CONCLUSIONS
  The only difference in morbidity of obese patients who were mechanically ventilated was increased difficulty with tracheal intubation and a higher frequency of post-extubation stridor. Obesity was not associated either with increased ICU mortality or with hospital mortality.
authors.affiliation: Medical ICU, CHU Poitiers, Poitiers, France. j.p.frat@chu-poitiers.fr
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Frat
authors.forename: Valérie
authors.initials: V
authors.lastname: Gissot
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Ragot
authors.forename: Arnaud
authors.initials: A
authors.lastname: Desachy
authors.forename: Isabelle
authors.initials: I
authors.lastname: Runge
authors.forename: Christine
authors.initials: C
authors.lastname: Lebert
authors.forename: René
authors.initials: R
authors.lastname: Robert
mesh_terms: D000368:Aged; D015992:Body Mass Index; D016009:Chi-Square Distribution; D016638:Critical Illness; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007442:Intubation, Intratracheal; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000401:mortality / Q000503:physiopathology; D011379:Prognosis; D011446:Prospective Studies; D012121:Respiration, Artificial; D012307:Risk Factors; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric