[Functional genomics of nasopharyngeal carcinoma susceptibility/suppressor gene].
There is obvious allele disequilibrium in nasopharyngeal carcinoma at chromosome 3p, 9p, 6q, 11q, 13q and 14q. Nasopharyngeal carcinoma (NPC) susceptibility/suppressor gene candidates were obtained by molecular biology methods,such as cDNA representational difference ana-lysis. The functional research of NPC susceptibility/ suppressor gene candidates indicated: (1) The increased expression of Cx contributed to obstacles of gap junctional intercellular communication (GJIC), and resulted an aberration of GJIC; (2) BRD7, a transcript factor, was associated with cell cycle regulation; (3) NAG7,an estrogen receptor repressor, inhibited the invasive potential of human NPC cells by regulating ERalpha expression and the H-ras/p-c-Raf and JNK/AP-1/MMP1 signaling pathways; (4) NGX6, a metastasis-associated protein, can negative-regulate EGF/Ras/MAPK signaling transduction pathway, and interact with ezrin protein to inhibit invasion and metastasis of NPC cells; (5) SPLUNC1, a secreted protein, can inhibit the bacterium clone formation, and is an innate immune molecule. These data will lay an important foundation for the NPC mechanism.
Li
Xiao-Ling
XL
Cancer Research Institute, Central South University, Changsha 410078, China.
Wu
Ming-Hua
MH
Li
Gui-Yuan
GY
D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins / Q000235:genetics*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D023281:Genomics / Q000379:methods*; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010750:Phosphoproteins / Q000235:genetics*; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D014407:Tumor Cells, Cultured; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D000092468:Bromodomain Containing Proteins
D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D006023:Glycoproteins; D008565:Membrane Proteins; D010750:Phosphoproteins; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D025521:Tumor Suppressor Proteins; C485599:BPIFA1 protein, human; C485694:BRD7 protein, human; D000092468:Bromodomain Containing Proteins; C470228:LINC00312 long non-coding RNA, human; C477325:TMEM8B protein, human