title: Famciclovir substitution for patients with acyclovir-associated renal toxicity.
abstract: Acyclovir-induced nephrotoxicity is well known, but published literature lacks information on the safety of substitution with other antiviral agents. We describe four patients with acyclovir-induced renal toxicity that were subsequently managed with hydration and famciclovir. All four patients subsequently had improvements in their symptoms with full recovery of their baseline renal function.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Southern Illinois University School of Medicine, Springfield, P.O. Box-19636, IL 62794-9636, USA.
authors.forename: Tin Han
authors.initials: TH
authors.lastname: Htwe
authors.forename: Scott
authors.initials: S
authors.lastname: Bergman
authors.forename: Janak
authors.initials: J
authors.lastname: Koirala
mesh_terms: D015075:2-Aminopurine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000212:Acyclovir / Q000008:administration & dosage / Q000633:toxicity*; D000368:Aged; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000627:therapeutic use* / Q000633:toxicity*; D000077595:Famciclovir; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy*; D006562:Herpes Zoster / Q000188:drug therapy*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged
chemical_list: D000998:Antiviral Agents; D015075:2-Aminopurine; D000077595:Famciclovir; D000212:Acyclovir