Antipsychotic drugs and cerebrovascular events in elderly patients with dementia: a systematic review.
Recently, Canadian, US and European health regulatory agencies issued warnings about an increased risk of stroke and death in elderly patients with dementia receiving atypical antipsychotics. Assessing both randomised and non-randomised evidence, this systematic review found conflicting findings, particularly for risperidone. More research is needed to better inform clinical practice.
Mazzucco
Sara
S
Department of Neurological Sciences and Vision, Section of Clinical Neurology, University of Verona, Piazzale L.A. Scuro, 10, 37134 Verona, Italy. sara.mazzucco@univr.it
Cipriani
Andrea
A
Barbui
Corrado
C
Monaco
Salvatore
S
D000368:Aged; D014150:Antipsychotic Agents / Q000737:chemistry / Q000627:therapeutic use*; D002561:Cerebrovascular Disorders / Q000150:complications*; D003704:Dementia / Q000150:complications* / Q000188:drug therapy*; D006801:Humans
D014150:Antipsychotic Agents