title: Development of a new questionnaire to assess patient perceptions of cancer-related fatigue: item generation and item reduction.
abstract: OBJECTIVE
  Existing instruments that measure the impact of cancer-related fatigue on health-related quality of life do not usually incorporate the attitudes, beliefs and perspectives of patients. This study aimed to develop an instrument to measure the impact of cancer-related fatigue on the health-related quality of life of cancer patients.
  
  
  METHODS
  Items were generated from a literature review, focus groups of cancer patients and meetings with oncologists. Potential items were administered to cancer patients to facilitate item reduction, which was based on clinimetric and psychometric analyses and qualitative criteria. A preliminary assessment of feasibility, reliability and validity of the retained items was performed.
  
  
  RESULTS
  An initial pool of 75 items was administered to 238 cancer patients. Fifty items were eliminated after statistical analysis and 13 in response to expert opinion, resulting in a provisional instrument with 12 items in 3 dimensions. These displayed acceptable internal consistency (Cronbach's alpha, 0.78-0.92) and their overall score was associated with fatigue intensity, extent of disease, intention of treatment and need of caregivers.
  
  
  CONCLUSIONS
  The newly developed questionnaire, which measures the impact of cancer-related fatigue on oncology patients, has shown satisfactory feasibility, reliability and validity.
authors.affiliation: 3D Health Research, Barcelona, Spain. ebaro@3d-hr.com
authors.forename: Eva
authors.initials: E
authors.lastname: Baró
authors.forename: Joan
authors.initials: J
authors.lastname: Carulla
authors.forename: Javier
authors.initials: J
authors.lastname: Cassinello
authors.forename: Ramón
authors.initials: R
authors.lastname: Colomer
authors.forename: Jesús García
authors.initials: JG
authors.lastname: Mata
authors.forename: Pere
authors.initials: P
authors.lastname: Gascón
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Gasquet
authors.forename: Michael
authors.initials: M
authors.lastname: Herdman
authors.forename: César A
authors.initials: CA
authors.lastname: Rodríguez
authors.forename: Jordi
authors.initials: J
authors.lastname: Sánchez
authors.forename: Vicente
authors.initials: V
authors.lastname: Valentín
mesh_terms: D001294:Attitude to Health; D005221:Fatigue / Q000150:complications / Q000209:etiology / Q000523:psychology*; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000523:psychology*; D011788:Quality of Life; D011795:Surveys and Questionnaires