Superior temporal gyrus spectral abnormalities in schizophrenia.
Considerable evidence indicates early auditory stimulus processing abnormalities in schizophrenia, but the mechanisms are unclear. The present study examined oscillatory phenomena during a paired-click paradigm in the superior temporal gyrus (STG) as a possible core problem. The primary question addressed is whether first click and/or second click group differences in the time-domain evoked response in patients with schizophrenia are due to (1) group differences in the magnitude of poststimulus oscillatory activity, (2) group differences in poststimulus phase-locking, and/or (3) group differences in the magnitude of ongoing background oscillatory activity. Dense-array magnetoencephalography from 45 controls and 45 patients with schizophrenia produced left- and right-hemisphere STG 50- and 100-ms time-frequency evoked, phase-locking, and total power measures. Whereas first click 100-ms evoked theta and alpha abnormalities were observed bilaterally, evoked low beta-band differences were specific to the left hemisphere. Compared to controls, patients with schizophrenia showed more low-frequency phase variability, and the decreased 100-ms S1 evoked response observed in patients was best predicted by the STG phase-locking measure.
Edgar
J Christopher
JC
Department of Psychology, Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. edgarj@email.chop.edu
Hanlon
Faith M
FM
Huang
Ming-Xiong
MX
Weisend
Michael P
MP
Thoma
Robert J
RJ
Carpenter
Bruce
B
Hoechstetter
Karsten
K
Cañive
José M
JM
Miller
Gregory A
GA
D000328:Adult; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000473:pathology*; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000473:pathology*