title: [Treatment in cases of recurrent vaginal candida infection during pregnancy].
abstract: OBJECTIVE
  To study the therapeutic application of Gynazol in cases of recurrent vaginal Candida infections during the last trimester of pregnancy.
  
  
  METHODS
  28 pregnant women in third trimester with recurrent vaginal Candida infection were included in the study. All cases were treated with a single vaginal application of Gynazol (butoconazole nitrate 2%). Follow up of reported subjective complaints and control vaginal swab and culture 10-14 days after treatment was performed.
  
  
  CONCLUSIONS
  In 24 (85.72%) cases of recurrent vaginal Candida infection, Candida albicans was isolated. C. tropicalis and C. parapsilosis were found in 3 (10.71%) and 1 (3.57%) cases respectively. Single vaginal application of Gynazol led to alleviation of subjective symptoms 24-48 hours after initiation of treatment. Control vaginal swab and culture were performed in 24 patients. Negative cultures were found in 21 cases (87.5%) and single Candida colonies were isolated in 3 (12.5%) patients. According to our results, application of Gynazol is recommended in cases of recurrent vaginal Candida infection during third trimester of pregnancy.
authors.forename: A
authors.initials: A
authors.lastname: Nikolov
authors.forename: E
authors.initials: E
authors.lastname: Shopova
authors.forename: M
authors.initials: M
authors.lastname: Mikhova
authors.forename: A
authors.initials: A
authors.lastname: Dimitrov
mesh_terms: D000282:Administration, Intravaginal; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000517:prevention & control*; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D055502:Secondary Prevention; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; C017125:butoconazole