title: Treatment of esophageal spirocercosis with milbemycin oxime.
abstract: Six medium sized mixed breed dogs treated with milbemycin oxime (11.5mg on days 0, 7 and 28 and then monthly) stopped shedding Spirocerca lupi ova after 3-44 days. There was no evidence of subsequent shedding in repeated tests (about 5/dog) carried out from 31 to 133 days after initiation of treatment. Esophageal nodules disappeared in all dogs within 95-186 days and radiographic signs resolved within 85-127 days in the five dogs that were studied. This preliminary data shows milbemycin oxime deserves further evaluation for the treatment of spirocercosis.
authors.affiliation: Ross University School of Veterinary Medicine, P.O. Box 334, Basseterre, St Kitts and Nevis, West Indies.
authors.forename: P J
authors.initials: PJ
authors.lastname: Kelly
authors.forename: M
authors.initials: M
authors.lastname: Fisher
authors.forename: H
authors.initials: H
authors.lastname: Lucas
authors.forename: R C
authors.initials: RC
authors.lastname: Krecek
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004334:Drug Administration Schedule; D004935:Esophageal Diseases / Q000469:parasitology / Q000662:veterinary*; D018942:Macrolides / Q000008:administration & dosage / Q000627:therapeutic use*; D017205:Spirurida Infections / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000871:Anthelmintics; D018942:Macrolides; C078973:milbemycin oxime