Effect of beta-adrenoblockers on heart rate variability in awake and narcotized rats.
In narcotized rats, beta-adrenoceptor blockers changed all parameters of heart rate variability indicating up-regulation of parasympathetic activity and down-regulation of the sympathetic one. In immobilized awake rats, the temporal and geometrical parameters varied similarly, while spectral analysis indicated possible activation of other neurohumoral mechanisms against the background of beta-blocker treatment.
Sal'nikov
E V
EV
Department of Biology, Yaroslavl State Medical Academy.
Fateev
M M
MM
Sidorov
A V
AV
Fedorov
V N
VN
Grigor'eva
M V
MV
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001262:Atenolol / Q000494:pharmacology; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D014851:Wakefulness
D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D011433:Propranolol