title: Immunohistochemical profiles of brain metastases from breast cancer.
abstract: The aim of present study is to explore the immunohistochemical profiles of brain metastases from breast cancer. We retrospectively performed immunohistochemical staining for estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor type 2 (HER2/neu), and cytokeratin (CK) 5/6 in 29 patients with resected tumor specimens of brain metastases. Immunohistochemical staining for ER, PgR and HER2/neu was performed in 24 patients with primary tumors. The positive frequency of immunohistochemical profiles of ER, PgR, HER2/neu, and CK5/6, in the brain metastases were 13.8%, 6.9%, 37.9%, and 24.1%, respectively. The immunohistochemical profiles including ER, PgR, and HER2/neu of the primary tumor and the brain metastasis differed in seven patients (29.2%, N = 7/24). Interestingly, the biological characteristics of brain metastasis sometimes changed which were represented by immunohistochemical staining. Therefore, the changes in the biological features of breast cancer should be taken into account when developing treatment strategies, including new molecular-targeted drugs, for brain metastases.
authors.affiliation: Breast and Medical Oncology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. yonemori-kan@pmda.go.jp
authors.forename: Kan
authors.initials: K
authors.lastname: Yonemori
authors.forename: Koji
authors.initials: K
authors.lastname: Tsuta
authors.forename: Chikako
authors.initials: C
authors.lastname: Shimizu
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hatanaka
authors.forename: Kaoru
authors.initials: K
authors.lastname: Hashizume
authors.forename: Makiko
authors.initials: M
authors.lastname: Ono
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Miyakita
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Narita
authors.forename: Soichiro
authors.initials: S
authors.lastname: Shibui
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fujiwara
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism* / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology*; D016009:Chi-Square Distribution; D004815:Epidermal Growth Factor / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007633:Keratins / Q000378:metabolism*; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D012189:Retrospective Studies
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D004815:Epidermal Growth Factor; D007633:Keratins