Comment on "Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain".
Manganas et al. (Reports, 9 November 2007, p. 980) used a metabolic biomarker identified in vitro to characterize the existence of neural progenitor cells in vivo. Although their detailed experiments and general approach are laudable, aspects of their magnetic resonance spectroscopy data and analyses raise questions about their results.
Friedman
Seth D
SD
Department of Radiology, University of Washington, 1959 Northeast Pacific Street, Seattle, WA 98195, USA. sethf@u.washington.edu
D000465:Algorithms; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D015415:Biomarkers / Q000032:analysis*; D001921:Brain / Q000166:cytology*; D006801:Humans; D008055:Lipids / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009474:Neurons / Q000737:chemistry / Q000166:cytology*; D013234:Stem Cells / Q000737:chemistry / Q000166:cytology*
D015415:Biomarkers; D008055:Lipids; D001224:Aspartic Acid; C000179:N-acetylaspartate