Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection - an update (1998 - 2007).
The high number of citations of the previous review on anti-HIV compounds from plants published in 1998 in Planta Medica indicates the importance of natural products research in the battle against HIV. Therefore, we have decided to write an update of our previous review paper, this time covering the time span 1998 - 2007. The following antiviral chemical classes are discussed in detail: alkaloids, carbohydrates, coumarins, flavonoids, lignans, phenolics, proteins, quinones/xanthones, tannins and terpenes. If available, chemical structures, antiviral activity and selectivity, mechanism of action, and structure-activity relationship are presented.
Cos
Paul
P
Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Department of Pharmaceutical Sciences, University of Antwerp, Belgium. paul.cos@ua.ac.be
Maes
Louis
L
Vlietinck
Arnold
A
Pieters
Luc
L
D000470:Alkaloids / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000032:analysis / Q000627:therapeutic use*; D002241:Carbohydrates / Q000627:therapeutic use; D005419:Flavonoids / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D017705:Lignans / Q000627:therapeutic use; D010636:Phenols / Q000627:therapeutic use; D008517:Phytotherapy; D010940:Plant Proteins / Q000627:therapeutic use; D010944:Plants / Q000737:chemistry*; D013634:Tannins / Q000627:therapeutic use; D013729:Terpenes / Q000627:therapeutic use
D000470:Alkaloids; D019380:Anti-HIV Agents; D002241:Carbohydrates; D005419:Flavonoids; D017705:Lignans; D010636:Phenols; D010940:Plant Proteins; D013634:Tannins; D013729:Terpenes