title: Micelles as containers for self-assembled nanodevices: a fluorescent sensor for lipophilicity.
abstract: Potentiometric titrations, fluorescence versus pH titrations, dynamic light scattering and fluorescence polarization anisotropy studies demonstrate that inside the nanodimensioned Triton X-100 micelles, 1-pyrenecarboxylic acid, PCOO(-), forms an apical complex with the Zn(2+) cation encircled by a lipophilic cyclen ligand and hugely increasing its fluorescence. The ability of the Zn(2+)-cyclen-PCOO(-) complex plus its micellar container to act as a fluorescent sensor to evaluate the lipophilicity of molecular species is demonstrated on the fatty acid series CH(3)(CH(2))(x)COOH (x=0-16). At pH 7.4 a decrease in fluorescence is observed on the addition of fatty acids that is directly related to their chain length, that is, to their tendency to enter the micellar containers, where they dislocate PCOO(-) from the Zn(2+) centre. The independent determination of fatty acid pK(a) values in the presence of Triton X-100 micelles confirms that our fluorescent micellar device is capable of sensing their lipophilicity.
authors.affiliation: Dipartimento di Fisica G. Occhialini, Università Milano Bicocca, Piazza della Scienza 3, 20126 Milano, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Chirico
authors.forename: Maddalena
authors.initials: M
authors.lastname: Collini
authors.forename: Laura
authors.initials: L
authors.lastname: D'Alfonso
authors.forename: Franck
authors.initials: F
authors.lastname: Denat
authors.forename: Yuri A
authors.initials: YA
authors.lastname: Diaz-Fernandez
authors.forename: Luca
authors.initials: L
authors.lastname: Pasotti
authors.forename: Yoann
authors.initials: Y
authors.lastname: Rousselin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Sok
authors.forename: Piersandro
authors.initials: P
authors.lastname: Pallavicini