Liver diseases and metabolic syndrome.
Emerging attention has been paid to metabolic syndrome, which comprises several metabolic disorders including visceral obesity, diabetes mellitus, dyslipidemia, and hypertension. Whether the severity of each disease is mild to moderate, the comorbidity of these metabolic disorders has a serious impact on the development of atherosclerosis. Nonalcoholic fatty liver disease (NAFLD) is the major hepatic disorder in patients with metabolic syndrome, and indeed it is the most common cause of abnormal liver function tests in the working population in industrialized countries. In recent years, it has become recognized that NAFLD is no longer just a trivial disease, and a rather considerable proportion of the patients develop liver cirrhosis. Furthermore, chronic infection of hepatitis C virus also develops a pathological feature of steatohepatitis, and extended hepatic steatosis has a serious impact not only on the progression of hepatic fibrosis but also on the antiviral efficacy of interferon therapy. Emerging lines of studies indicated that insulin resistance, abnormal lipid metabolism, and dysregulation of cytokines/adipokines (e.g., tumor necrosis factor-alpha, adiponectin, and leptin) are profoundly involved in the pathogenesis of NAFLD. This review aims to integrate the reported evidence and to provide the current point of view for comprehensive understanding of the pathophysiology of steatohepatitis.
Watanabe
Sumio
S
Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Yaginuma
Reiko
R
Ikejima
Kenichi
K
Miyazaki
Akihisa
A
D050197:Atherosclerosis / Q000209:etiology; D018450:Disease Progression; D005234:Fatty Liver / Q000150:complications / Q000503:physiopathology; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008103:Liver Cirrhosis / Q000209:etiology; D008107:Liver Diseases / Q000150:complications* / Q000503:physiopathology; D008113:Liver Neoplasms / Q000209:etiology; D024821:Metabolic Syndrome / Q000150:complications* / Q000821:virology; D008930:Mitochondria, Liver / Q000502:physiology