SIRT1 is a circadian deacetylase for core clock components.
The transcriptional activator CLOCK is a histone acetyltransferase that is required for the circadian expression of many genes. Asher et al. (2008) and Nakahata et al. (2008) now demonstrate that the NAD(+)-dependent enzyme SIRT1 functions as a histone deacetylase that counteracts the activity of CLOCK. These results broaden our understanding of the impact of cellular metabolism on the circadian system.
Belden
William J
WJ
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA.
Dunlap
Jay C
JC
D000107:Acetylation; D000818:Animals; D056926:CLOCK Proteins; D002940:Circadian Rhythm; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D037761:Sirtuins / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*
D015534:Trans-Activators; D056926:CLOCK Proteins; C538943:CLOCK protein, human; D037761:Sirtuins; D006655:Histone Deacetylases