[Effect of taurine and thioctacide on carbohydrate metabolism and the antioxydant system in rats with experimental diabetes].
Peroral administration of taurine and thioctacide in rats with alloxan-induced diabetes (i) decreased the levels of glucose, fructosamine and MDA, (ii) increased the levels of glycogen, insulin, and C-peptide in the liver, and (iii) increased the levels of enzymes of the antioxidant system of catalase and paraoxonase as compared to the control group of animals. These effects show that taurine and thioctacide possess hypoglycemic and antioxidant properties.
Gavrovskaia
L K
LK
Ryzhova
O V
OV
Safonova
A F
AF
Aleksandrova
I Ia
IIa
Sapronov
N S
NS
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D043303:Aryldialkylphosphatase / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D050260:Carbohydrate Metabolism / Q000187:drug effects*; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D019270:Fructosamine / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000097:blood; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood / Q000134:cerebrospinal fluid; D051381:Rats; D013654:Taurine / Q000627:therapeutic use*; D008063:Thioctic Acid / Q000627:therapeutic use*
D000975:Antioxidants; D002096:C-Peptide; D007004:Hypoglycemic Agents; D007328:Insulin; D013654:Taurine; D019270:Fructosamine; D008063:Thioctic Acid; D006003:Glycogen; D002374:Catalase; D043303:Aryldialkylphosphatase; D005947:Glucose