title: Formulation study of intravesical oxybutynin instillation solution with enhanced retention in bladder.
abstract: A formulation study of intravesical oxybutynin (OB) preparations was carried out in order to improve the effectiveness in intravesical instillation therapy for spastic neurogenetic bladder. Sodium hyaluronate (HYA) was introduced to enhance the muco-adhesiveness of the instillation preparation, and the physicochemical properties of the OB formulation were evaluated in comparison with a conventional formulation containing hydroxypropylcellulose (HPC). The viscous properties and in vitro adhesiveness increased with the amount of the polymeric additives, and retention properties of OB in rabbit bladder were comparable after addition of 0.4% HYA and 1.0% HPC. HYA was able to enhance the intravesical retention properties of OB instillation solution to a lesser degree than HPC, it seemed to be a useful additive in the OB instillation due to its safety and mucosal-protective effect.
authors.affiliation: Department of Pharmacy, University Hospital, University of Yamanashi, Yamanashi, Japan. t-hanawa@yamanashi.ac.jp
authors.forename: Takehisa
authors.initials: T
authors.lastname: Hanawa
authors.forename: Chikako
authors.initials: C
authors.lastname: Tsuchiya
authors.forename: Naoko
authors.initials: N
authors.lastname: Endo
authors.forename: Kazumi
authors.initials: K
authors.lastname: Hanawa
authors.forename: Masahiko
authors.initials: M
authors.lastname: Suzuki
authors.forename: Taeko
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kiminori
authors.initials: K
authors.lastname: Mohri
authors.forename: Toshio
authors.initials: T
authors.lastname: Oguchi
mesh_terms: D000268:Adhesiveness; D000283:Administration, Intravesical; D000818:Animals; D006820:Hyaluronic Acid / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008297:Male; D008333:Mandelic Acids / Q000737:chemistry*; D011817:Rabbits; D012146:Rest / Q000502:physiology*; D012153:Retention, Psychology; D001743:Urinary Bladder / Q000378:metabolism; D014783:Viscosity
chemical_list: D008333:Mandelic Acids; D006820:Hyaluronic Acid; C005419:oxybutynin