title: Successful therapy with ABLC, surgery and posaconazole for Rhizopus microsporus var. rhizopodiformis liver eumycetoma in a child with acute leukaemia.
abstract: Invasive fungal infection negatively influences the morbidity and mortality in heavily immuno-incompetent patients. Diagnosis of non-Aspergillus mould infections remains challenging despite application of a wide spectrum of non-culture-based microbiological techniques. Invasive diagnostic procedures are often essential. In this article, we present the case of a 15-month-old boy diagnosed with Rhizopus microsporus var. rhizopodiformis liver mycetoma during induction chemotherapy for acute promyelocytic leukaemia. Following surgery, he was effectively treated with a combination of ABLC and posaconazole during ongoing intensive chemotherapy. Posaconazole was also used as long-term secondary prophylaxis.
authors.forename: Petr
authors.initials: P
authors.lastname: Sedlacek
authors.forename: Vladimir
authors.initials: V
authors.lastname: Vavra
authors.forename: Ivana
authors.initials: I
authors.lastname: Masova
authors.forename: Daniel
authors.initials: D
authors.lastname: Codl
authors.forename: Tana
authors.initials: T
authors.lastname: Laznickova
authors.forename: Ludmila
authors.initials: L
authors.lastname: Malaskova
authors.forename: Otakar
authors.initials: O
authors.lastname: Nyc
authors.forename: Jan
authors.initials: J
authors.lastname: Stary
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D008099:Liver / Q000382:microbiology / Q000601:surgery; D008107:Liver Diseases / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery / Q000628:therapy*; D008297:Male; D008271:Mycetoma / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery / Q000628:therapy*; D012233:Rhizopus / Q000302:isolation & purification*; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C068538:liposomal amphotericin B; C101425:posaconazole; D000666:Amphotericin B