title: Rapid carvedilol up-titration in hospitalized patients with systolic heart failure.
abstract: To determine whether carvedilol can be safely up-titrated before hospital discharge, we studied 372 consecutive patients with systolic heart failure who were being treated with carvedilol. Carvedilol was initiated a median of 3 days after admission, with a mean starting dose of 12 mg. Up-titration was performed in 67% of patients, with a mean increase of 16 mg and a mean discharge daily dose of 23 +/- 17 mg. Mean daily dose at the end of follow-up was 35.3 +/- 25.3 mg and it increased with higher discharge dose.
authors.affiliation: Division of Cardiology, Hospital Universitario Gregorio Marañón, Madrid, Spain. mmselles@secardiologia.es
authors.forename: Manuel
authors.initials: M
authors.lastname: Martínez-Sellés
authors.forename: Tomás
authors.initials: T
authors.lastname: Datino
authors.forename: Marta
authors.initials: M
authors.lastname: Alhama
authors.forename: Nelida
authors.initials: N
authors.lastname: Barrueco
authors.forename: Isabel
authors.initials: I
authors.lastname: Castillo
authors.forename: Francisco
authors.initials: F
authors.lastname: Fernández-Avilés
mesh_terms: D000368:Aged; D002227:Carbazoles / Q000627:therapeutic use*; D000077261:Carvedilol; D004305:Dose-Response Relationship, Drug; D005260:Female; D054143:Heart Failure, Systolic / Q000188:drug therapy*; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use*; D012189:Retrospective Studies; D013997:Time Factors; D017186:Titrimetry; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D002227:Carbazoles; D011412:Propanolamines; D014665:Vasodilator Agents; D000077261:Carvedilol