The effect of donepezil on increased regional cerebral blood flow in the posterior cingulate cortex of a patient with Parkinson's disease dementia.
It has been reported that the cholinesterase inhibitor, donepezil, improves cognitive decline in patients with Parkinson's disease dementia (PDD). However, this improvement was dominant for frontal lobe dysfunction, and the increase in the Mini-Mental State Examination (MMSE) score was minimal. We report a PDD patient with a decline of regional cerebral blood flow (rCBF) in the posterior cingulate cortex, precunei, and bilateral parietotemporal association cortex, as determined by single-photon emission computed tomography (SPECT) using the easy Z-scores imaging system (e-ZIS). Upon administration of donepezil, both the rCBF and MMSE score increased. The effectiveness of donepezil may vary based on the rCBF pattern in PDD.
Imamura
Keiko
K
Department of Neurology, Institute of Neurological Sciences, Yonago, Japan. imamurakeiko@nifty.com
Wada-Isoe
Kenji
K
Kowa
Hisanori
H
Tanabe
Yoshio
Y
Nakashima
Kenji
K
D000368:Aged; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003704:Dementia / Q000188:drug therapy / Q000209:etiology; D000077265:Donepezil; D006179:Gyrus Cinguli / Q000098:blood supply* / Q000502:physiology; D006801:Humans; D007189:Indans / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000494:pharmacology / Q000627:therapeutic use; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects*; D016896:Treatment Outcome
D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D000077265:Donepezil