Heat shock proteins and neurodegenerative disorders.
Heat shock proteins (HSPs) are evolutionarily conserved molecules and play important roles in fundamental cellular processes. They serve as molecular chaperones and hence provide a protective function in ensuring cell survival and repair of cellular damage after a stressful stimulus. This paper summarizes the current knowledge about the different roles of HSPs in aging and disease, focusing on the neurodegenerative disorders of Alzheimer's marks disease, Parkinson's disease, Huntington's marks disease, and prion disease.
Soo
Eliza Ting-Li
ET
Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Ng
Yee-Kong
YK
Bay
Boon-Huat
BH
Yip
George Wai-Cheong
GW
D000375:Aging / Q000502:physiology; D000818:Animals; D006360:Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000503:physiopathology*
D006360:Heat-Shock Proteins