title: Pt/TiO2 brain biocompatible nanoparticles: GBM treatment using the C6 model in Wistar rats.
abstract: In the present work we synthesized inorganic oxide nanoparticle carriers of platinum compounds and tested their therapeutic effect on animal models in which C6 glioma cells have been inoculated. TiO(2)-containing Pt(NH(3))(4)Cl(2) complexes were synthesized using sol-gel methods. The platinum species are chemically bonded to the TiO(2) carrier, as shown by Fourier transform infrared spectroscopy of probe molecules. Treatment with TiO(2)-Pt nanoparticles reduces tumour growth rate by up to 56%, showing that a synergistic effect exists between the TiO(2) carrier and the platinum drug.
authors.affiliation: Universidad Autónoma Metropolitana-Xochimilco, Health Department, Calzada del Hueso 1100, México DF 04960, México.
authors.forename: T
authors.initials: T
authors.lastname: López
authors.forename: S
authors.initials: S
authors.lastname: Recillas
authors.forename: P
authors.initials: P
authors.lastname: Guevara
authors.forename: J
authors.initials: J
authors.lastname: Sotelo
authors.forename: M
authors.initials: M
authors.lastname: Alvarez
authors.forename: J A
authors.initials: JA
authors.lastname: Odriozola
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001932:Brain Neoplasms / Q000628:therapy*; D045744:Cell Line, Tumor; D004337:Drug Carriers; D005909:Glioblastoma / Q000628:therapy*; D008297:Male; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry; D044367:Phase Transition; D010984:Platinum / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D014025:Titanium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D008823:Micelles; C009495:titanium dioxide; D010984:Platinum; D014025:Titanium