title: Yttrium-90 ibritumomab tiuxetan radioimmunotherapy in primary cutaneous B-cell lymphomas: first results of a prospective, monocentre study.
abstract: Radioimmunotherapy with Yttrium-90 ((90)Y) ibritumomab tiuxetan (IT) has been shown to be effective in systemic B-cell lymphomas. We conducted a pilot study to evaluate the outcome and assess complications of (90)Y IT therapy in patients with primary cutaneous B-cell lymphomas (PCBCL). Ten patients, all but one, with relapsed PCBCL were included and treated with rituximab (250 mg m(-2)/body surface) on days 1 and 8 followed by a single dose of (90)Y IT (11-15 MBq kg(-1)). The overall response rate was 100%. The complete response rate was 100%. The median time to relapse was 12 months. Ongoing remissions were achieved in four patients (median follow-up 19 months). Transient and reversible myelosuppression (grade 3-4) was the most frequent adverse event. Radioimmunotherapy with (90)Y IT is an effective treatment in relapsed primary cutaneous follicle centre lymphomas and diffuse large B-cell lymphoma leg-type. Further investigations in controlled randomised clinical trials evaluating the role of (90)Y IT versus rituximab in PCBCL are needed.
authors.affiliation: Clinic for Nuclear Medicine, Charite-Universitatsmedizin Berlin, Berlin, Germany.
authors.forename: Sofiane
authors.initials: S
authors.lastname: Maza
authors.forename: Sylke
authors.initials: S
authors.lastname: Gellrich
authors.forename: Chalid
authors.initials: C
authors.lastname: Assaf
authors.forename: Marc
authors.initials: M
authors.lastname: Beyer
authors.forename: Laura
authors.initials: L
authors.lastname: Spilker
authors.forename: Helmut
authors.initials: H
authors.lastname: Orawa
authors.forename: Dieter L
authors.initials: DL
authors.lastname: Munz
authors.forename: Wolfram
authors.initials: W
authors.lastname: Sterry
authors.forename: Matthias
authors.initials: M
authors.lastname: Steinhoff
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D016499:Radioimmunotherapy / Q000009:adverse effects / Q000379:methods*; D012074:Remission Induction; D016879:Salvage Therapy; D012878:Skin Neoplasms / Q000532:radiotherapy*; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000627:therapeutic use* / Q000633:toxicity
chemical_list: D000911:Antibodies, Monoclonal; D015021:Yttrium Radioisotopes; C422802:ibritumomab tiuxetan