Anti-inflammatory activity of licochalcone A isolated from Glycyrrhiza inflata.
Licochalcone A was isolated from the roots of Glycyrrhiza inflata and evaluated for its anti-inflammatory activity in xylene-induced mice ear edema and carrageenan-induced paw edema tests. At the same time, the inhibition of prostaglandin biosynthesis by licochalcone A was also studied in lipopolysaccharide (LPS)-induced mouse macrophage cells. At 5 mg/ ear, licochalcone A showed remarkable effects against acute inflammation induced by xylene, and at the doses of 2.5, 5, 10 mg/kg (p.o.), licochalcone A reduced significantly paw edema induced by carrageenan compared to the control at the fourth hour. Both COX-2 activity and expression were significantly inhibited by licochalcone A at all the test doses. Therefore, licochalcone A could be a useful compound for the development of new anti-inflammatory agents.
Cui
Yongming
Y
College of Life Science and Technology, Institute of Resource Biology and Biotechnology, Huazhong University of Science & Technology, Wuhan 430074, China.
Ao
Mingzhang
M
Li
Wei
W
Hu
Jing
J
Yu
Longjiang
L
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology; D047188:Chalcones / Q000302:isolation & purification* / Q000494:pharmacology; D051546:Cyclooxygenase 2 / Q000187:drug effects / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D006035:Glycyrrhiza / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D008815:Mice, Inbred Strains; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D047188:Chalcones; D008070:Lipopolysaccharides; D051546:Cyclooxygenase 2; D015232:Dinoprostone