title: Urinary isoprostanes in Friedreich ataxia: lack of correlation with disease features.
abstract: To assess the utility of urinary isoprostanes as markers of oxidative injury in Friedreich ataxia (FA), we compared levels of urinary F(2)-isoprostanes in patients with FA and healthy control subjects. Levels of urinary F(2)-isoprostanes in FA patients were not different from controls and were not significantly associated with age, GAA repeat length, disability level, or the use of antioxidants. Thus, urinary F(2)-isoprostanes are not a useful biomarker in FA.
authors.affiliation: Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Myers
authors.forename: David R
authors.initials: DR
authors.lastname: Lynch
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Farmer
authors.forename: Lisa S
authors.initials: LS
authors.lastname: Friedman
authors.forename: John A
authors.initials: JA
authors.lastname: Lawson
authors.forename: Robert B
authors.initials: RB
authors.lastname: Wilson
mesh_terms: D000328:Adult; D005260:Female; D005621:Friedreich Ataxia / Q000652:urine*; D006801:Humans; D028421:Isoprostanes / Q000652:urine*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D028421:Isoprostanes