[Study on effect of demethoxycurcumin in Curcuma long on stability of curcumin].
OBJECTIVE
To investigate effect of demethoxycurcumin on stability of curcumin.


METHODS
To add the demethoxycurcumin to pure curcumin, the change of curcumin was determined by HPLC and the dynamics of curcumin degradation was investigated.


RESULTS
The stability both obtained from alcohol and demethoxycurcumin improved the stabilization of curcumin, the demi-period of curcumin prolonged with the addition of demethoxycurcumin.


CONCLUSIONS
The commixture of curcumin and demethoxycurcumin are more stable than pure curcumin at the same conditions. Stability of curcumin is improved by demethoxycurcumin,it is crude stabilizing agent.
Han
Gang
G
Tangshan Key Laboratory of New Drug Research, Pharmaceutical Department of North China Coal Medical College, Tangshan 063000, China. tsyxhg@163.com
Bi
Rui
R
Le
Quan
Q
Zhao
Lin-Lin
LL
Dong
Yue
Y
Lin
Qing-Hui
QH
D002851:Chromatography, High Pressure Liquid; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification* / Q000378:metabolism; D036381:Diarylheptanoids; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification; D000431:Ethanol / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
D036381:Diarylheptanoids; D004365:Drugs, Chinese Herbal; D000431:Ethanol; D003474:Curcumin; C050229:demethoxycurcumin