title: The non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) impairs late reconsolidation of passive avoidance learning in the day-old chick.
abstract: Both NMDA and non-NMDA receptors participate in the consolidation of passive avoidance learning (PAL) in the day-old chick. NMDA antagonists have also been implicated in reconsolidation processes following reminder-trials. In this study, we examined the effect of administering 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a non-NMDA receptor antagonist, on reconsolidation following memory reactivation. New Hampshire x White leghorn cockerels were trained using a modified version of the PAL task. When CNQX was administered 20 min following a reminder trial, a retention deficit was detected at 90 min, but this had resolved by 24 h following the reminder. The parameters of the reconsolidation deficit were similar to those induced by CNQX injections post-training with the exception of their transience. This finding suggests that the action of non-NMDA receptors may perform a similar role in both consolidation and reconsolidation processes.
authors.affiliation: School of Psychological Science, La Trobe University, Bundoora 3086, Australia.
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Sherry
authors.forename: Simon F
authors.initials: SF
authors.lastname: Crowe
mesh_terms: D018750:6-Cyano-7-nitroquinoxaline-2,3-dione / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002645:Chickens; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D018091:Receptors, AMPA / Q000378:metabolism*
chemical_list: D018691:Excitatory Amino Acid Antagonists; D018091:Receptors, AMPA; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione