[Effects of Yiqi Sanju Formula on non-alcoholic fatty liver disease: a randomized controlled trial].
OBJECTIVE
To observe the therapeutic effects of Yiqi Sanju Formula (YQSJF), a compound traditional Chinese herbal medicine, in treatment of non-alcoholic fatty liver disease (NAFLD).


METHODS
Sixty-seven patients diagnosed with NAFLD were randomly divided into two groups: YQSJF-treated group (39 cases) and placebo group (28 cases). The NAFLD patients in the two groups were treated with YQSJF and placebo respectively for 3 months. Clinical symptoms, the CT ratio of liver-spleen, body mass index (BMI), waist circumference, homeostatic model assessment for insulin resistance (HOMA2-IR) and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-alpha (TNF-alpha), high sensitivity C-reactive protein (hs-CRP), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were evaluated before and after treatment.


RESULTS
After treatment, the clinical symptoms were improved and the levels of BMI, waist circumference, HOMA2-IR, ALT, AST, TG and TC were decreased significantly in the YQSJF-treated group (P<0.05). The CT ratio of liver-spleen in the YQSJF-treated group was increased significantly as compared with the placebo group (P<0.01).
Lou
Shao-ying
SY
Institution of Chinese Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Liu
Yi
Y
Ma
Yu-ying
YY
Chen
Hai-ying
HY
Chen
Wei-hua
WH
Ying
Jian
J
He
Yan-ming
YM
Wang
Wen-jian
WJ
D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005234:Fatty Liver / Q000188:drug therapy*; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; C528001:Yiqi Sanju formula; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase