Study of bipathic effect of phenazepam.
Phenazepam in ultralow doses significantly potentiated anxiolytic and anticonvulsant effects of therapeutic doses of the same drug both after preliminary or simultaneous administration, which attests to bipathic action of phenazepam. The combination of ultralow and therapeutic doses of phenazepam prevented the development of its specific myorelaxant and sedative side effects.
Epstein
O I
OI
Materia Medica Holding Research-and-Production Company, Moscow.
Voronina
T A
TA
Molodavkin
G M
GM
Belopol'skaya
M V
MV
Kheyfets
I A
IA
Dugina
J L
JL
Sergeeva
S A
SA
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011897:Random Allocation; D051381:Rats
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; C017928:phenazepam