title: Phosphine-free Cp*Ru(diamine) catalysts in the hydrogenation of imines.
abstract: We previously reported the phosphine-free Cp*Ru(diamine)-catalyzed hydrogenation of aryl methyl ketones. Herein we present the first report of ruthenium-diamine-catalyzed imine hydrogenation to form amines. The most effective catalyst, I/KOtBu, completely converted several imines to amines at room temperature. The effect of electron-donating and -withdrawing groups on the reaction was investigated using a suitable series of substrates. The asymmetric version of the reaction was studied for two substrates, and the chiral amine products could be obtained in moderate enantiomeric excess.
authors.affiliation: Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, Husargatan 3, BMC, 75123, Uppsala, Sweden.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Cheruku
authors.forename: Tamara L
authors.initials: TL
authors.lastname: Church
authors.forename: Pher G
authors.initials: PG
authors.lastname: Andersson
mesh_terms: D002384:Catalysis; D003959:Diamines / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry; D017975:Ruthenium Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
chemical_list: D003959:Diamines; D007097:Imines; D008024:Ligands; D010720:Phosphines; D017975:Ruthenium Compounds; D014867:Water; C044646:phosphine