Effect of inhibitors of arachidonic acid conversion in platelets on thrombin-fibrinogen interaction and thrombin tolerance.
Experiments on 200 rats showed that inhibitors of arachidonic acid conversion capable of reducing coagulation activity of platelets decrease the content of markers for thrombin--fibrinogen interaction in the plasma and, therefore, decelerate intravascular blood coagulation and increase thrombin tolerance.
Shapovalova
E M
EM
Department of Biochemistry, Tyumen Medical Academy, Russian Ministry of Health. biochem@tgma.info
Rudzevich
A J
AJ
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005340:Fibrinogen / Q000737:chemistry / Q000378:metabolism*; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011796:Quinacrine / Q000494:pharmacology; D051381:Rats; D013917:Thrombin / Q000737:chemistry / Q000378:metabolism*
D007093:Imidazoles; C029166:dazoxiben; D016718:Arachidonic Acid; D005340:Fibrinogen; D013917:Thrombin; D011796:Quinacrine; D001241:Aspirin