Synthesis of two persistent fluorinated tetrathiatriarylmethyl (TAM) radicals for biomedical EPR applications.
Tetrathiatriarylmethyl radicals are attractive spin probes extensively used in biomedical magnetic resonance applications. We report a straightforward synthesis of two original tetrathiatriarylmethyl radicals incorporating, respectively, 15 and 45 fluorine atoms, and thus possessing a high affinity to fluorous media. F15T-03 and F45T-03 exhibit a single sharp EPR spectrum and their EPR line broadening is highly sensitive to molecular oxygen. These spin probes are specially designed for assessment of tumor oxygenation using perfluorocarbon formulations.
Driesschaert
Benoît
B
Unité de Chimie Organique et Médicinale, Université catholique de Louvain, UCL, place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium.
Charlier
Nicolas
N
Gallez
Bernard
B
Marchand-Brynaert
Jacqueline
J
D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005609:Free Radicals / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism; D013440:Sulfides / Q000138:chemical synthesis* / Q000737:chemistry
C530570:F15T-03; C530571:F45T-03; D005609:Free Radicals; D006845:Hydrocarbons, Fluorinated; D013440:Sulfides; D010100:Oxygen