Generation of multilayered structures for biomedical applications using a novel tri-needle coaxial device and electrohydrodynamic flow.
In this short communication, we describe the scope and flexibility of using a novel device containing three coaxially arranged needles to form a variety of novel morphologies. Different combinations of materials are subjected to controlled flow through the device under the influence of an applied electric field. The resulting electrohydrodynamic flow allows us to prepare double-layered bubbles, porous encapsulated threads and nanocapsules containing three layers. The ability to process such multilayered structures is very significant for biomedical engineering applications, for example, generating capsules for drug delivery, which can provide multistage controlled release.
Ahmad
Z
Z
Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK. ucemzah@ucl.ac.uk
Zhang
H B
HB
Farook
U
U
Edirisinghe
M
M
Stride
E
E
Colombo
P
P
D001698:Biomedical Engineering / Q000295:instrumentation*; D016503:Drug Delivery Systems / Q000379:methods*; D004553:Electric Conductivity; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D011140:Polyurethanes / Q000737:chemistry*; D013500:Surface Tension; D014783:Viscosity
D011140:Polyurethanes