The hunt for cyclin.
It is 25 years since Tim Hunt discovered cyclin, the oscillating protein that drives activation of cyclin-dependent kinases and entry into mitosis (Evans et al., 1983).
Jackson
Peter K
PK
Genentech, Inc., Department of Cell Regulation, South San Francisco, CA 94080, USA. pjackson@gene.com
D000818:Animals; D001671:Biochemistry / Q000266:history; D002453:Cell Cycle; D018797:Cell Cycle Proteins; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D016213:Cyclins / Q000235:genetics / Q000378:metabolism*; D049673:History, 20th Century; D016200:Maturation-Promoting Factor / Q000378:metabolism; D008938:Mitosis; D008967:Molecular Biology / Q000266:history; D012617:Sea Urchins
D018797:Cell Cycle Proteins; D016213:Cyclins; D018844:Cyclin-Dependent Kinases; D016200:Maturation-Promoting Factor