Simple obesity is associated with reduced breast arterial calcification and increased plasma osteopontin level.
BACKGROUND
We undertook this study to evaluate whether simple obesity is associated with breast arterial calcifications.


METHODS
Mammograms and patient records of 1309 women who underwent screening or diagnostic mammography were reviewed retrospectively. Patients were divided into two groups according to body mass index. Mammograms were evaluated for the presence of arterial calcification and results were coded. Plasma osteopontin levels were measured.


RESULTS
The prevalence of breast arterial calcification of patients classified with simple obesity was lower than the non-obese group. Obese group exhibited significantly increased circulating osteopontin concentrations as compared with non-obese group. Plasma osteopontin level is an independent protective factor for the presence of breast arterial calcification.


CONCLUSIONS
Simple obesity is associated with reduced breast arterial calcification. Our study indicates the use of breast artery calcification as an indicator of cardiovascular disease or arterial status should be reconsidered.
Xue
Song
S
Department of Cardiovascular Surgery, RenJi Hospital of Shanghai Jiaotong University, Shanghai, People's Republic of China.
Shen
Dafu
D
Gao
Hua
H
Wang
Yongyi
Y
D001158:Arteries / Q000473:pathology*; D001940:Breast / Q000098:blood supply*; D002114:Calcinosis; D005260:Female; D006801:Humans; D009765:Obesity / Q000473:pathology*; D053495:Osteopontin / Q000097:blood*; D012189:Retrospective Studies
D053495:Osteopontin