APOE epsilon4 is associated with postictal confusion in patients with medically refractory temporal lobe epilepsy.
This study examined the relationship between the APOE epsilon4 allele and postictal confusion in patients with medically intractable temporal lobe epilepsy (TLE). Patients with at least one epsilon4 allele (n=22) were three times more likely to exhibit postictal confusion (68%) than the 63 patients without epsilon4 (43%). These preliminary results demonstrate that APOE epsilon4 is associated with an increased risk of postictal confusion in patients with medically intractable TLE, suggesting possible dysfunction in neuronal recovery mechanisms.
Chapin
Jessica S
JS
Epilepsy Center, Department of Psychiatry and Psychology, Neurological Institute, Cleveland Clinic P57, 9500 Euclid Avenue, Cleveland, OH 44195, United States. smerzj@ccf.org
Busch
Robyn M
RM
Janigro
Damir
D
Dougherty
Michelle
M
Tilelli
Cristiane Q
CQ
Lineweaver
Tara T
TT
Naugle
Richard I
RI
Diaz-Arrastia
Ramon
R
Najm
Imad M
IM
D000328:Adult; D053327:Apolipoprotein E4 / Q000235:genetics*; D016009:Chi-Square Distribution; D003221:Confusion / Q000150:complications* / Q000235:genetics*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D053327:Apolipoprotein E4