title: A new dihydroagarofuranoid sesquiterpene and antituberculosis constituents from the root of Microtropis japonica.
abstract: A new dihydroagarofuran-based sesquiterpene, 15-acetoxyorbiculin A, was isolated from the root of Microtropis japonica, together with 13 known compounds. Their structures were determined through in-depth spectroscopic and mass-spectrometric analyses. Among the isolated compounds, celahin C and salasol A exhibited potent in vitro antituberculosis activity, both with an MIC value of 15.0 microg/ml against Mycobacterium tuberculosis H(37)Rv.
authors.affiliation: Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Tsung-Hsien
authors.initials: TH
authors.lastname: Chou
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Chien-Fang
authors.initials: CF
authors.lastname: Peng
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D029753:Celastraceae / Q000737:chemistry*; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C531477:15-acetoxyorbiculin A; D000995:Antitubercular Agents; D012717:Sesquiterpenes