Which treatment for nonalcoholic fatty liver disease?
Subjects with nonalcoholic fatty liver disease are at risk of progressive liver failure. Lifestyle changes including weight-loss strategies and increased physical activity remain the first-line approach, but a few pharmacological treatments have also been successfully tested. Several drugs improve biochemistry, only a few improve histology; in all cases, the results were not sustained after treatment stop. Pharmacological treatment is not so far indicated outside controlled clinical trials with histological outcomes.
Moscatiello
S
S
Unit of Clinical Dietetics, "Alma Mater Studiorum" University of Bologna, Policlinico S. Orsola, Via Massarenti, 9, I-40138 Bologna, Italy.
Marzocchi
R
R
Villanova
N
N
Bugianesi
E
E
Marchesini
G
G
D000438:Alcohols / Q000009:adverse effects; D000818:Animals; D005234:Fatty Liver / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D024821:Metabolic Syndrome / Q000188:drug therapy; D015431:Weight Loss / Q000187:drug effects
D000438:Alcohols