title: FOXA transcription factors determine the amplitude of glucocorticoid induction of tyrosine aminotransferase in mice.
abstract: o-Aminoazotoluene was more potent than 3'-methyl-4-dimethylaminoazobenzene in modulating glucocorticoid induction of tyrosine aminotransferase and DNA-binding activity of FOXA (HNF3) in 12-day-old ICR mice. In adult animals, induction of tyrosine aminotransferase and FOXA activity were modulated by o-aminoazotoluene, while 3'-methyl-4-dimethylaminoazobenzene was ineffective. Our results suggest that FOXA proteins determine glucocorticoid induction of tyrosine aminotransferase in mice (similarly to rats).
authors.affiliation: Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk. leon_l@ngs.ru
authors.forename: L O
authors.initials: LO
authors.lastname: Bryzgalov
authors.forename: N I
authors.initials: NI
authors.lastname: Ershov
authors.forename: S I
authors.initials: SI
authors.lastname: Ilnitskaya
mesh_terms: D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D005938:Glucocorticoids / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D008749:Methyldimethylaminoazobenzene; D051379:Mice; D008813:Mice, Inbred ICR; D011485:Protein Binding / Q000187:drug effects; D013997:Time Factors; D014444:Tyrosine Transaminase / Q000378:metabolism*; D009762:o-Aminoazotoluene
chemical_list: D051858:Forkhead Transcription Factors; D005938:Glucocorticoids; D008749:Methyldimethylaminoazobenzene; D014444:Tyrosine Transaminase; D009762:o-Aminoazotoluene