title: [A case of advanced gastric cancer responding to paclitaxel/CDDP neoadjuvant chemotherapy leading to pathologically complete response].
abstract: A 74-year-old male with advanced gastric cancer(cT3N1M0H0P0CY0, cStage III A)was treated with paclitaxel/ CDDP as neoadjuvant chemotherapy. Paclitaxel (80 mg/m(2)) and CDDP (25 mg/m(2)) were administered on days 1, 8 and 15 as one cycle. After the second course, a significant tumor reduction was obtained. Total gastrectomy, splenectomy, and D2 type nodal dissection were performed. The histological diagnosis revealed complete disappearance of cancer cells in the stomach and all of the lymph nodes, a so-called pathologically complete response. The patient has now been in good health without any recurrence for 9 months after surgery. This case suggests that neoadjuvant chemotherapy with paclitaxel/CDDP is a potential regimen for advanced gastric cancer.
authors.affiliation: Dept. of Surgery, Nagano Municipal Hospital.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sakon
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sekino
authors.forename: Kouichi
authors.initials: K
authors.lastname: Okita
authors.forename: Kei
authors.initials: K
authors.lastname: Kusama
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Seki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Munakata
authors.forename: Noriko
authors.initials: N
authors.lastname: Hosaka
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Mikami
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D020776:Endoscopes, Gastrointestinal; D005743:Gastrectomy; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D017239:Paclitaxel; D002945:Cisplatin