title: Functional neuroimaging in stroke recovery and neurorehabilitation: conceptual issues and perspectives.
abstract: BACKGROUND
  In stroke, functional neuroimaging has become a potent diagnostic tool; opened new insights into the pathophysiology of ischaemic damage in the human brain; and made possible the assessment of functional-structural relationships in postlesion recovery.
  
  
  CONCLUSIONS
  of review Here, we give a critical account on the potential and limitation of functional neuroimaging and discuss concepts related to the use of neuroimaging for exploring the neurobiological and neuroanatomical mechanisms of poststroke recovery and neurorehabilitation. We identify and provide evidence for five hypotheses that functional neuroimaging can provide new insights into: 1. adaptation occurs at the level of functional brain systems; 2. the brain-behaviour relationship varies with recovery and over time; 3. functional neuroimaging can improve our ability to predict recovery and select individuals for rehabilitation; 4. mechanisms of recovery reflect different pathophysiological phases; and 5. brain adaptation may be modulated by experience and specific rehabilitation.
authors.affiliation: National Stroke Research Institute, Neurosciences Building, Heidelberg Heights, Victoria, Australia. lcarey@nsri.org.au
authors.forename: Leeanne M
authors.initials: LM
authors.lastname: Carey
authors.forename: Rüdiger J
authors.initials: RJ
authors.lastname: Seitz
mesh_terms: D001921:Brain / Q000378:metabolism / Q000473:pathology*; D001925:Brain Damage, Chronic / Q000209:etiology / Q000473:pathology / Q000534:rehabilitation; D003289:Convalescence; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D009473:Neuronal Plasticity; D010101:Oxygen Consumption; D018579:Patient Selection; D011379:Prognosis; D020521:Stroke / Q000150:complications / Q000473:pathology*; D000071939:Stroke Rehabilitation