Synthesis and hypnotic activities of N-Cbz-alpha-aminoglutarimidooxy carboxylate derivatives.
Typical hypnotic drugs, such as barbitals and glutethimide, have a cyclic imide (-CO-NH-CO-) moiety. The N-Cbz-alpha-aminoglutarimidooxy carboxylate derivatives, which we previously showed exhibit moderate anticonvulsant activities, also have a cyclic imide (-CO-N-CO-) moiety. This structural similarity prompted us to examine the hypnotic activities of the N-Cbz-alpha-aminoglutarimidooxy carboxylate derivatives, and we describe their moderate hypnotic activities here.
Byun
Aesun
A
College of Pharmacy, Kyungsung University, Busan, Korea.
Park
Jin Yup
JY
Moon
Kyung Hee
KH
Park
Min Soo
MS
D000616:Aminoglutethimide / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D002697:Chloral Hydrate / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012890:Sleep / Q000187:drug effects; D013055:Spectrophotometry, Infrared
D006993:Hypnotics and Sedatives; D007202:Indicators and Reagents; D000616:Aminoglutethimide; D002697:Chloral Hydrate