Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.
Host immune responses are known determinants of gastric cancer susceptibility. We previously reported an increased gastric cancer risk associated with common variants of several T helper type 1 (Th1) cytokine genes in a population-based case-control study in Warsaw, Poland. In the present study, we augmented our investigation to include additional Th1 genes as well as key genes in the Th2 and Th3 pathways. Analysis of 378 cases and 435 age- and sex-matched controls revealed associations for polymorphisms in the Th1 IL7R gene and one polymorphism in the Th2 IL5 gene. The odd ratios (ORs) for IL7R rs1494555 were 1.4 [95% confidence interval (CI), 1.0-1.9] for A/G and 1.5 (95% CI, 1.0-2.4) for G/G carriers relative to A/A carriers (P = 0.04). The ORs for IL5 rs2069812 were 0.9 (95% CI, 0.7-1.3) for C/T and 0.6 (95% CI, 0.3-1.0) T/T carriers compared with C/C carriers (P = 0.03). These results suggest that IL5 rs2069812 and IL7R rs1389832, rs1494556 and rs1494555 polymorphisms may contribute to gastric cancer etiology.
Mahajan
Rajeev
R
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
El-Omar
Emad M
EM
Lissowska
Jolanta
J
Grillo
Paolo
P
Rabkin
Charles S
CS
Baccarelli
Andrea
A
Yeager
Meredith
M
Sobin
Leslie H
LH
Zatonski
Witold
W
Channock
Stephen J
SJ
Chow
Wong-Ho
WH
Hou
Lifang
L
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000235:genetics*; D060908:CTLA-4 Antigen; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000276:immunology; D016480:Helicobacter pylori; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D016555:Matched-Pair Analysis; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D015291:Transforming Growth Factors / Q000235:genetics*; D044465:White People / Q000235:genetics
D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D007378:Interleukins; D015291:Transforming Growth Factors