Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection.
2-(2-Methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, a novel anilidoquinoline derivative, was synthesised and evaluated for its therapeutic efficacy in treating Japanese encephalitis. The compound showed significant antiviral and antiapoptotic effects in vitro. Significant decreases in viral load (P<0.01) combined with an increase in survival was observed in Japanese encephalitis virus-infected mice treated with 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide.
Ghosh
Joydeep
J
National Brain Research Centre, Manesar, Haryana, India.
Swarup
Vivek
V
Saxena
Amit
A
Das
Sulagna
S
Hazra
Abhijit
A
Paira
Priyankar
P
Banerjee
Sukdeb
S
Mondal
Nirup B
NB
Basu
Anirban
A
D000081:Acetamides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D000083:Acetanilides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000634:Aminoquinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D004664:Encephalitis Virus, Japanese / Q000187:drug effects / Q000472:pathogenicity*; D004672:Encephalitis, Japanese / Q000188:drug therapy* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
C533850:2-(2-methylquinolin-4-ylamino)-N-(2-chlorophenyl)acetamide; D000081:Acetamides; D000083:Acetanilides; D000634:Aminoquinolines; D000998:Antiviral Agents; D018696:Neuroprotective Agents; D011804:Quinolines; C030686:acetamide; C037219:quinoline