title: Argatroban in short-term percutaneous ventricular assist subsequent to heparin-induced thrombocytopenia.
abstract: Heparin-induced thrombocytopenia paradoxically is a transient pro-thrombotic disorder triggered by heparin exposure. If not treated appropriately, it can be life threatening because of its related thromboembolic complications. In particular, it presents a unique challenge in patients needing extracorporeal life support, because anticoagulation is essential for safe management. This case report describes the safe, efficacious use of Argatroban during short-term support of a patient with a percutaneously inserted left ventricular assist TandemHeart device.
authors.affiliation: Vanderbilt Heart Institute, Division of Perfusion Services, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. david.webb@vanderbilt.edu
authors.forename: David P
authors.initials: DP
authors.lastname: Webb
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Warhoover
authors.forename: Susan S
authors.initials: SS
authors.lastname: Eagle
authors.forename: James P
authors.initials: JP
authors.lastname: Greelish
authors.forename: David X
authors.initials: DX
authors.lastname: Zhao
authors.forename: John G
authors.initials: JG
authors.lastname: Byrne
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006353:Heart-Assist Devices; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010875:Pipecolic Acids / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010976:Platelet Count; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy*
chemical_list: D005343:Fibrinolytic Agents; D010875:Pipecolic Acids; D010975:Platelet Aggregation Inhibitors; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban