title: An adolescent with rhabdomyosarcoma during pregnancy.
abstract: We report the case of a 15-year-old girl with a large gluteal and perineal rhabdomyosarcoma diagnosed at 24 weeks of pregnancy, whose management posed a great clinical dilemma for us. The patient refused to consider a therapeutic abortion, so we opted for a customized treatment with mild doses of chemotherapy administered weekly to control tumor growth while minimizing fetal and perinatal complications. After the delivery of a healthy female, we adopted a more intensive chemotherapy regimen plus irradiation. Despite an initially good response, the disease unfortunately progressed and the patient died of her disease.
authors.affiliation: Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. cristina.meazza@istitutotumori.mi.it
authors.forename: Cristina
authors.initials: C
authors.lastname: Meazza
authors.forename: Michela
authors.initials: M
authors.lastname: Casanova
authors.forename: Elena
authors.initials: E
authors.lastname: Zaffignani
authors.forename: Carlo Alfredo
authors.initials: CA
authors.lastname: Clerici
authors.forename: Francesca
authors.initials: F
authors.lastname: Favini
authors.forename: Roberto
authors.initials: R
authors.lastname: Vasquez
authors.forename: Andrea
authors.initials: A
authors.lastname: Ferrari
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002081:Buttocks; D017024:Chemotherapy, Adjuvant; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D010502:Perineum; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy / Q000532:radiotherapy; D018714:Radiotherapy, Adjuvant; D012208:Rhabdomyosarcoma / Q000188:drug therapy / Q000532:radiotherapy