Hemodynamic improvement as an additional parameter to evaluate the safety and tolerability of the molecular adsorbent recirculating system in liver failure patients.
BACKGROUND
The molecular adsorbent recirculating system (MARS) is an extracorporeal acute liver failure (ALF) support system method using albumin-enriched dialysate to remove albumin-bound toxins.


METHODS
Since 1999 we performed 2027 MARS treatments in 191 patients: 39 fulminant hepatic failure (FHF), 16 primary nonfunction (PNF), 21 delayed function (DF), 94 acute-on-chronic liver failure (AoCHF), 7 post-hepatic resection, and 14 intractable pruritus.


RESULTS
We divided the complications by the AoCHF versus the ALF populations. Among 83 ALF patients, we observed worsening of hemodynamic parameters in 16 patients: 3 with PNF, 2 with DF without retransplantation, 9 with FHF, and 2 after hepatic resection. Among 94 AoCHF patients, 42 showed hemodynamic instability requiring intensive care unit support. Our study did not note significant adverse effects (1.8%), except for infections and hemorrhage from the central venous catheter not due to MARS treatment. The thrombocytopenia was controlled through administration of platelets before the start of treatment when a patient showed a level under 30,000 mm(3).


CONCLUSIONS
Our results confirmed that nonbiological hepatic support by MARS was safe and tolerable.
Pugliese
F
F
Scienze Anestesiologiche, Medicina Critica e Terapia del Dolore, La Sapienza Università di Roma, Rome, Italy.
Novelli
G
G
Poli
L
L
Levi Sandri
G B
GB
Di Folco
G
G
Ferretti
S
S
Morabito
V
V
Ruberto
F
F
Berloco
P B
PB
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D017093:Liver Failure / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy*; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D012189:Retrospective Studies; D012449:Safety; D016060:Sorption Detoxification / Q000379:methods*; D014655:Vascular Resistance
D009638:Norepinephrine