title: Apoptotic sensitivity of murine IAP-deficient cells.
abstract: Although numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli.
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Julie M
authors.initials: JM
authors.lastname: Rumble
authors.forename: Mathieu J M
authors.initials: MJ
authors.lastname: Bertrand
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Csomos
authors.forename: Casey W
authors.initials: CW
authors.lastname: Wright
authors.forename: Lori
authors.initials: L
authors.lastname: Albert
authors.forename: Tak W
authors.initials: TW
authors.lastname: Mak
authors.forename: Philip A
authors.initials: PA
authors.lastname: Barker
authors.forename: Colin S
authors.initials: CS
authors.lastname: Duckett
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051034:Inhibitor of Apoptosis Proteins / Q000172:deficiency*; D008297:Male; D051379:Mice; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000172:deficiency
chemical_list: D051034:Inhibitor of Apoptosis Proteins; D051636:X-Linked Inhibitor of Apoptosis Protein