Apoptotic sensitivity of murine IAP-deficient cells.
Although numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli.
Rumble
Julie M
JM
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Bertrand
Mathieu J M
MJ
Csomos
Rebecca A
RA
Wright
Casey W
CW
Albert
Lori
L
Mak
Tak W
TW
Barker
Philip A
PA
Duckett
Colin S
CS
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051034:Inhibitor of Apoptosis Proteins / Q000172:deficiency*; D008297:Male; D051379:Mice; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000172:deficiency
D051034:Inhibitor of Apoptosis Proteins; D051636:X-Linked Inhibitor of Apoptosis Protein