Cell survival and chromosomal aberrations in CHO-K1 cells irradiated by carbon ions.
Chinese hamster ovary CHO-K1 cells were exposed to high LET (12)C-beam (LET: 830 keV/microm) in the dose range of 0-6 Gy and to (60)Co irradiation and the RBE value was obtained. Effects of (12)C-beam exposure on cell survival and chromosomal aberrations were calculated. The chromosomal aberration data were fitted with linear equation. The distribution of aberration in cells was examined with a standard u-test and used to evaluate the data according to Poisson probabilities. The variance to the mean ratio sigma(2)/Y and the dispersion index (u) were determined. Overdispersion was significant (p<0.05) when the value of u exceeded 1.96.
Czub
J
J
Institute of Physics, Swietokrzyska Academy, ul. Swietokrzyska 15, 25-406 Kielce, Poland.
Banaś
D
D
Błaszczyk
A
A
Braziewicz
J
J
Buraczewska
I
I
Choiński
J
J
Górak
U
U
Jaskóła
M
M
Korman
A
A
Lankoff
A
A
Lisowska
H
H
Łukaszek
A
A
Szefliński
Z
Z
Wójcik
A
A
D000818:Animals; D016466:CHO Cells / Q000528:radiation effects; D002250:Carbon Radioisotopes; D002470:Cell Survival / Q000528:radiation effects*; D002869:Chromosome Aberrations / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D007477:Ions; D016012:Poisson Distribution; D011827:Radiation
D002250:Carbon Radioisotopes; D007477:Ions