title: Cembrane diterpenes from the gorgonian Leptogorgia laxa.
abstract: The new cembrane diterpenes leptodienone A (2) and leptodienone B (3) and the known compounds lopholide, lophodiol B, lophodione, and lophotoxin (1) have been isolated from the gorgonian Leptogorgia laxa collected in the Gulf of California. The structures of the new metabolites have been established by spectroscopic techniques. The in vitro cytotoxicity of the new compounds has been tested against three human tumor cell lines.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias del Mar y Ambientales, Universidad de Cádiz, Apartado 40, 11510-Puerto Real (Cádiz), Spain.
authors.forename: María J
authors.initials: MJ
authors.lastname: Ortega
authors.forename: Eva
authors.initials: E
authors.lastname: Zubía
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Sánchez
authors.forename: J Luis
authors.initials: JL
authors.lastname: Carballo
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002140:California; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D013729:Terpenes; C532730:leptodienone A; C532731:leptodienone B; C030303:lophotoxin