title: [Three cases of stomatitis caused by chemotherapy for gastrointestinal cancer that responded well to lafutidine].
abstract: We described 3 cases of stomatitis caused by chemotherapy with the fluoropyrimidine preparation S-1, alone or combined with other anticancer drugs. The stomatitis did not respond to conventional oral mucosal treatment such as triamcinolone acetonide(Kenalog)or allopurinol, but improved after treatment with the histamine H2-receptor antagonist lafutidine. The concurrent use of lafutidine allowed these 3 patients to continue chemotherapy with no recurrence of stomatitis. We concluded that lafutidine may be a viable treatment option for chemotherapy-induced stomatitis, allowing treatment to be continued.
authors.affiliation: Dept. of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Uchida
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hayashi
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Kuramochi
authors.forename: Go
authors.initials: G
authors.lastname: Nakajima
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D013280:Stomatitis / Q000150:complications* / Q000188:drug therapy*
chemical_list: D000081:Acetamides; D010880:Piperidines; D011725:Pyridines; C076948:lafutidine