title: Posaconazole combined with amphotericin B, an effective therapy for a murine disseminated infection caused by Rhizopus oryzae.
abstract: In a murine model of disseminated zygomycosis, low doses of amphotericin B (0.3 mg/kg body weight/day) combined with posaconazole (40 mg/kg/day) prolonged survival and reduced tissue burden with respect to that of controls and that of both drugs administered alone. Results were similar to those obtained with amphotericin B given alone at 0.8 mg/kg/day.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: M Mar
authors.initials: MM
authors.lastname: Rodríguez
authors.forename: Carolina
authors.initials: C
authors.lastname: Serena
authors.forename: Marçal
authors.initials: M
authors.lastname: Mariné
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Pastor
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage*; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D051379:Mice; D009091:Mucormycosis / Q000188:drug therapy* / Q000382:microbiology; D012233:Rhizopus / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity; D014230:Triazoles / Q000008:administration & dosage*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B