Fatal intoxication using amantadine and pramipexole in a uremic patient.
We report a fatal intoxication in a 59-year-old woman who had uremia undergoing hemodialysis, and then took amantadine and pramipexole for Parkinsonian tremor. Toxic manifestation includes myoclonus, ataxia, confusion and sudden death. This report highlights the fact that using amantadine and pramipexole may be fatal in patients with uremia even undergoing hemodialysis.
Hong
Chien-Tai
CT
Department of Neurology, En Chu Kong Hospital, Taipei, Taiwan.
Sun
Yu
Y
Lu
Chien-Jung
CJ
D000547:Amantadine / Q000506:poisoning*; D000978:Antiparkinson Agents / Q000506:poisoning*; D052160:Benzothiazoles / Q000506:poisoning*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*; D000077487:Pramipexole; D014511:Uremia / Q000378:metabolism*
D000978:Antiparkinson Agents; D052160:Benzothiazoles; D000077487:Pramipexole; D000547:Amantadine