High dietary inorganic phosphate enhances cap-dependent protein translation, cell-cycle progression, and angiogenesis in the livers of young mice.
Inorganic phosphate (P(i)) plays a key role in diverse physiological functions. Recent studies have indicated that P(i) affects Akt signaling through the sodium-dependent phosphate cotransporter. Akt signaling, in turn, plays an important role in liver development; however, the effects of high dietary P(i) on the liver have not been investigated. Here, we examined the effects of high dietary phosphate on the liver in developing mice. We found that high dietary P(i) increased liver mass through enhancing Akt-related cap-dependent protein translation, cell cycle progression, and angiogenesis. Thus careful regulation of P(i) consumption may be important in maintaining normal development of the liver.
Xu
Cheng-Xiong
CX
Lab. of Toxicology, Coll. of Veterinary Med., Seoul National Univ., Seoul 151-742, Korea.
Jin
Hua
H
Lim
Hwang-Tae
HT
Kim
Ji-Eun
JE
Shin
Ji-Young
JY
Lee
Eun-Sun
ES
Chung
Youn-Sun
YS
Lee
Yeon-Sook
YS
Beck
George
G
Lee
Kee Ho
KH
Cho
Myung-Haing
MH
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects*; D018797:Cell Cycle Proteins; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004032:Diet; D039561:Eukaryotic Initiation Factor-4E / Q000378:metabolism; D039642:Eukaryotic Initiation Factors; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis; D008099:Liver / Q000098:blood supply / Q000187:drug effects / Q000254:growth & development*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis; D051379:Mice; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D010710:Phosphates / Q000008:administration & dosage*; D010750:Phosphoproteins / Q000378:metabolism; D014176:Protein Biosynthesis / Q000187:drug effects*; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; C499527:Eif4ebp1 protein, mouse; D039561:Eukaryotic Initiation Factor-4E; D039642:Eukaryotic Initiation Factors; D010710:Phosphates; D010750:Phosphoproteins; D042461:Vascular Endothelial Growth Factor A; C467480:vascular endothelial growth factor A, mouse; D016222:Fibroblast Growth Factor 2; D051057:Proto-Oncogene Proteins c-akt; D020778:Matrix Metalloproteinase 2; C522362:Mmp2 protein, mouse