title: Absolute stereochemistry of amphidinolide Q.
abstract: The absolute configurations at five chiral centers in amphidinolide Q (1), a cytotoxic 12-membered macrolide isolated from a marine dinoflagellate Amphidinium sp., were elucidated to be 4R, 7R, 9S, 11R, and 13R on the basis of NMR analyses and a modified Mosher's method.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kubota
authors.forename: Eri
authors.initials: E
authors.lastname: Fukushi
authors.forename: Jun
authors.initials: J
authors.lastname: Kawabata
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry; D018942:Macrolides / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D013237:Stereoisomerism; D000097442:Amphidinolides
chemical_list: D018942:Macrolides; C532855:amphidinolide Q; D000097442:Amphidinolides