title: Glycopeptide insensitive Staphylococcus aureus subdural empyema treated with linezolid and rifampicin.
abstract: A 4-year-old boy had surgical debulking of a cerebral astrocytoma followed by chemotherapy. He developed a subdural empyema with a teicoplanin and methicillin resistant Staphylococcus aureus. He was successfully treated with surgical drainage and 6 weeks of antibiotic therapy which included linezolid, rifampicin and metronidazole. Linezolid may be successful in treating other CNS infections caused by antibiotic resistant gram-positive organisms.
authors.affiliation: Department of Infectious Diseases, Royal Liverpool Children's Hospital, Liverpool, L12 2AP, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: Gallagher
authors.forename: B
authors.initials: B
authors.lastname: Pizer
authors.forename: J A
authors.initials: JA
authors.lastname: Ellison
authors.forename: F A I
authors.initials: FA
authors.lastname: Riordan
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D004322:Drainage; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D013354:Empyema, Subdural / Q000382:microbiology* / Q000628:therapy*; D006801:Humans; D000069349:Linezolid; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000627:therapeutic use*; D012293:Rifampin / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy*; D017334:Teicoplanin / Q000627:therapeutic use
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D017334:Teicoplanin; D000069349:Linezolid; D012293:Rifampin