title: Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic beta-cell function in type 2 diabetic mice.
abstract: Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) was isolated from Artemisia princeps to investigate the dose-response effects on blood glucose regulation and pancreatic beta-cell function in type 2 diabetic mice. Db/db mice were divided into control (eupatilin-free, AIN-76 standard diet), low-Eupa (0.005g/100g diet) and high-Eupa (0.02g/100g diet) groups. The supplementation of eupatilin for 6 weeks significantly lowered fasting blood glucose concentration while it increased hepatic glycogen content. In particular, high-Eupa reduced hemoglobin A(1c) and plasma glucagon levels along with a simultaneous increase in plasma insulin and adiponectin levels. The supplementation of eupatilin significantly lowered hepatic glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities, while it increased glucokinase activity in the liver. The pancreatic insulin concentration was higher in the eupatilin-supplemented groups. Also the pancreatic insulin concentration of eupatilin groups was higher than the control group. These results suggest that eupatilin played the role of an antidiabetic functional component in A. princeps by enhancing hepatic and plasma glucose metabolism as well as by increasing insulin secretion in type 2 diabetic mice.
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Daegu 702-701, South Korea.
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Kang
authors.forename: Un Ju
authors.initials: UJ
authors.lastname: Jung
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Seon-Min
authors.initials: SM
authors.lastname: Jeon
authors.forename: Yong Bok
authors.initials: YB
authors.lastname: Park
authors.forename: Hae-Gon
authors.initials: HG
authors.lastname: Chung
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Kyung Tae
authors.initials: KT
authors.lastname: Lee
authors.forename: Tae-Sook
authors.initials: TS
authors.lastname: Jeong
authors.forename: Myung-Sook
authors.initials: MS
authors.lastname: Choi
mesh_terms: D000818:Animals; D019306:Artemisia / Q000737:chemistry*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004435:Eating / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D020799:Pancrelipase / Q000378:metabolism; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D005419:Flavonoids; D005947:Glucose; D005952:Glucose-6-Phosphatase; D006442:Glycated Hemoglobin; D007328:Insulin; D008112:Liver Glycogen; D020799:Pancrelipase; D010729:Phosphoenolpyruvate Carboxykinase (GTP); C045325:eupatilin