Prostaglandin D2 receptors DP and CRTH2 in the pathogenesis of asthma.
Prostaglandin D2 (PGD2) is a major prostanoid produced mainly by mast cells in allergic diseases, including bronchial asthma. However, its role in the pathogenesis of asthma remains unclear. PGD2-induced vasodilatation and increased permeability are well-known classical effects that may facilitate transendothelial migration of inflammatory cells, such as eosinophils, mast cells, lymphocytes, and monocytes in allergic inflammation. These effects are initiated via a PGD2 receptor, D prostanoid receptor (DP), and are referred to as DP-mediated vasodilation-extravasation. Recently, novel functions of DP have been identified. Furthermore, a novel and different receptor of PGD2, CRTH2, has been discovered. To date, DP and CRTH2 have been shown to be major PGD(2)-related receptors that have pivotal roles in mediating allergic diseases by effects such as directly regulating the migration of inflammatory cells and controlling the production of cytokines and lipid mediators. Available evidence suggests that CRTH2 and DP may collaborate in allergic inflammation. This review focuses on the novel roles of DP and CRTH2 in the initiation and maintenance of allergy.
Arima
Masafumi
M
Department of Developmental Genetics (H2), Graduate School of Medicine, Chiba University, Japan.
Fukuda
Takeshi
T
D000818:Animals; D001249:Asthma / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D015230:Prostaglandin D2 / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000502:physiology*; D011982:Receptors, Prostaglandin / Q000502:physiology*
D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; D015230:Prostaglandin D2; C036293:prostaglandin D2 receptor