Antileishmanial activity of aldonamides and N-acyl-diamine derivatives.
A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC50 against L. chagasi below 5 microM.
Coimbra
Elaine S
ES
Departamento de Parasitologia, Microbiologia e Imunologia, Instituto de CiênciasBiológicas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900, Juiz de Fora, MG, Brazil. elaine.coimbra@ufjf.edu.br
Almeida
Camila G
CG
Júnior
Wilson V
WV
Dos Reis
Roberta C N
RC
De Almeida
Ana C F
AC
Forezi
Luana S M
LS
De Almeida
Mauro V
MV
Le Hyaric
Mireille
M
D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D003959:Diamines / Q000737:chemistry / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology*
D000577:Amides; D003959:Diamines; D014344:Trypanocidal Agents