title: Palladium-catalyzed direct (hetero)arylation of ethyl oxazole-4-carboxylate: an efficient access to (hetero)aryloxazoles.
abstract: A straightforward route toward 2-(hetero)arylated and 2,5-di(hetero)arylated oxazoles through regiocontrolled palladium-catalyzed direct (hetero)arylation of ethyl oxazole-4-carboxylate with iodo-, bromo-, and chloro(hetero)aromatics followed by a two-step hydrolysis/decarboxylation sequence was described. The method was applied here to a neat synthesis of two 2,5-di(hetero)aryloxazole natural products, balsoxin and texaline.
authors.affiliation: Institut de Chimie Organique Fine (IRCOF) associé au CNRS (UMR 6014), INSA et Université de Rouen, BP08 76131 Mont Saint Aignan, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Verrier
authors.forename: Thibaut
authors.initials: T
authors.lastname: Martin
authors.forename: Christophe
authors.initials: C
authors.lastname: Hoarau
authors.forename: Francis
authors.initials: F
authors.lastname: Marsais
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002264:Carboxylic Acids; D010080:Oxazoles; D010165:Palladium