Intriguing extracellular regulation of BMP signaling.
Extracellular components of the BMP signaling pathway bind specific partners with high affinity, implying regulation by dedicated protein-protein interactions. In this and other recent issues of Developmental Cell, new results by Ambrosio et al. (and others) suggest, however, that these factors interact in more complex ways to regulate BMP signaling on a fine scale.
Bier
Ethan
E
Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0349, USA. ebier@ucsd.edu
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D045726:Metalloproteases / Q000378:metabolism; D051379:Mice; D015398:Signal Transduction; D055394:Tolloid-Like Metalloproteinases; D014981:Xenopus / Q000196:embryology; D029867:Xenopus Proteins / Q000378:metabolism
D019485:Bone Morphogenetic Proteins; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D029867:Xenopus Proteins; C054234:chordin; D045726:Metalloproteases; D055394:Tolloid-Like Metalloproteinases