Low-dose aspirin and omega-3 fatty acids improve uterine artery blood flow velocity in women with recurrent miscarriage due to impaired uterine perfusion.
OBJECTIVE
To determine the effect of different therapeutic approaches on uterine artery blood flow in women with recurrent miscarriage (RM) and impaired uterine perfusion.


METHODS
Prospective, randomized study.


METHODS
Department of Obstetrics and Gynecology, University of Rome "Tor Vergata," Italy.


METHODS
Sixty women with unexplained RM and impaired uterine perfusion.


METHODS
Patients were randomly assigned to three different therapeutic regimens: 20 patients received a daily dose of 100 mg of aspirin (LDA); 20 patients were treated with omega-3 fatty acids (Omega(3)), 4 g daily; and 20 patients received LDA plus Omega(3).


METHODS
Doppler measurement of uterine artery pulsatility index (PI) was performed, in the midluteal phase of the cycle, before and after 2 months of therapy.


RESULTS
All therapeutic regimens induced an improvement in uterine perfusion with a significant reduction of uterine artery PI values. LDA alone or in combination with Omega(3) was found to achieve the highest improvement of uterine blood flow. Omega-3 supplementation was less effective, as reflected by the lower PI values.


CONCLUSIONS
LDA and Omega(3) are effective in improving uterine artery blood flow velocity in women with RM due to abnormal uterine perfusion. Further studies are needed to determine whether the improvement of uterine perfusion may lead to a better pregnancy outcome.
Lazzarin
Natalia
N
Department of Obstetrics and Gynecology, Ospedale Fatebenefratelli Isola Tiberina, University of Rome Tor Vergata, Lungotevere degli Angullara 12, Rome. Italy. nlazzarin@tiscali.it
Vaquero
Elena
E
Exacoustos
Caterina
C
Bertonotti
Elena
E
Romanini
Maria Elisabetta
ME
Arduini
Domenico
D
D000026:Abortion, Habitual / Q000517:prevention & control*; D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000517:prevention & control; D000328:Adult; D001158:Arteries / Q000000981:diagnostic imaging; D001241:Aspirin / Q000627:therapeutic use*; D001783:Blood Flow Velocity / Q000187:drug effects*; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010477:Perfusion; D011247:Pregnancy; D011446:Prospective Studies; D011674:Pulse; D014463:Ultrasonography; D014599:Uterus / Q000098:blood supply* / Q000187:drug effects
D016861:Cyclooxygenase Inhibitors; D015525:Fatty Acids, Omega-3; D001241:Aspirin