Nickel-catalyzed cross-coupling reactions of benzylic zinc reagents with aromatic bromides, chlorides and tosylates.
Benzylic zinc reagents prepared by direct insertion of zinc to benzylic chlorides in the presence of LiCl undergo smooth cross-coupling reactions with aromatic chlorides, bromides and tosylates using Ni(acac)(2) and PPh(3) as a catalyst system.
Schade
Matthias A
MA
Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, Haus F, 81377 München, Germany.
Metzger
Albrecht
A
Hug
Stephan
S
Knochel
Paul
P
D001593:Benzyl Compounds / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D014105:Tosyl Compounds / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D001593:Benzyl Compounds; D001965:Bromides; D002712:Chlorides; D014105:Tosyl Compounds; D009532:Nickel; D015032:Zinc