title: Advanced glycation end product (AGE)-induced proliferation of HEL cells via receptor for AGE-related signal pathways.
abstract: This study investigated whether advanced glycation end products (AGE) and RAGE (receptor for AGE) are involved in the proliferation of leukemia cells. AGE strongly induced the proliferation of primary acute myeloid leukemia (AML) cells and cell lines. MAP kinase, PI3K and JAK/STAT pathways were involved in cellular proliferation of HEL cells by AGE. RAGE antisense S-ODN effectively inhibited cell growth, induced apoptosis and reversed AGE-induced expression of targeting molecules in HEL cells. The study demonstrated for the first time that AGE directly induced human AML cell proliferation via the MAPK, PI3K and JAK/STAT pathways.
authors.affiliation: Cancer Research Institute, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Hyun Ki
authors.initials: HK
authors.lastname: Park
authors.forename: Jin Sun
authors.initials: JS
authors.lastname: Yoon
authors.forename: Seo Ju
authors.initials: SJ
authors.lastname: Kim
authors.forename: Eun Shil
authors.initials: ES
authors.lastname: Kim
authors.forename: Kwang Sung
authors.initials: KS
authors.lastname: Ahn
authors.forename: Dong-Sun
authors.initials: DS
authors.lastname: Kim
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Yoon
authors.forename: Byoung Kook
authors.initials: BK
authors.lastname: Kim
authors.forename: Young Yiul
authors.initials: YY
authors.lastname: Lee
mesh_terms: D015153:Blotting, Western; D049109:Cell Proliferation; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D005434:Flow Cytometry; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D047468:Immunoprecipitation; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050791:STAT Transcription Factors / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014407:Tumor Cells, Cultured
chemical_list: D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D050791:STAT Transcription Factors; D019869:Phosphatidylinositol 3-Kinases; D048049:Extracellular Signal-Regulated MAP Kinases