Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimer's research consortium study.
BACKGROUND
The Clinical Dementia Rating Scale Sum of Boxes (CDR-SOB) score is commonly used, although the utility regarding this score in staging dementia severity is not well established.


OBJECTIVE
To investigate the effectiveness of CDR-SOB scores in staging dementia severity compared with the global CDR score.


METHODS
Retrospective study.


METHODS
Texas Alzheimer's Research Consortium minimum data set cohort.


METHODS
A total of 1577 participants (110 controls, 202 patients with mild cognitive impairment, and 1265 patients with probable Alzheimer disease) were available for analysis.


METHODS
Receiver operating characteristic curves were generated from a derivation sample to determine optimal cutoff scores and ranges, which were then applied to the validation sample.


RESULTS
Optimal ranges of CDR-SOB scores corresponding to the global CDR scores were 0.5 to 4.0 for a global score of 0.5, 4.5 to 9.0 for a global score of 1.0, 9.5 to 15.5 for a global score of 2.0, and 16.0 to 18.0 for a global score of 3.0. When applied to the validation sample, kappa scores ranged from 0.86 to 0.94 (P < .001 for all), with 93.0% of the participants falling within the new staging categories.


CONCLUSIONS
The CDR-SOB score compares well with the global CDR score for dementia staging. Owing to the increased range of values, the CDR-SOB score offers several advantages over the global score, including increased utility in tracking changes within and between stages of dementia severity. Interpretive guidelines for CDR-SOB scores are provided.
O'Bryant
Sid E
SE
Department of Neuropsychiatry and Behavioral Science, Texas Tech University Health Sciences Center, 3601 4th St, STOP 8321, Lubbock, TX 79430, USA. sid.obryant@ttuhsc.edu
Waring
Stephen C
SC
Cullum
C Munro
CM
Hall
James
J
Lacritz
Laura
L
Massman
Paul J
PJ
Lupo
Philip J
PJ
Reisch
Joan S
JS
Doody
Rachelle
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000145:classification* / Q000175:diagnosis / Q000523:psychology*; D003072:Cognition Disorders / Q000145:classification / Q000175:diagnosis / Q000523:psychology; D015331:Cohort Studies; D003704:Dementia / Q000145:classification* / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013781:Texas