Dynamics of the mucosa-associated flora in ulcerative colitis patients during remission and clinical relapse.
The colonic mucosa-associated flora (MAF) in patients with active ulcerative colitis (UC) (n = 13) was investigated by examining 16S rRNA gene signatures during remission and relapse against levels for controls (n = 5). Baseline reduction, temporal instability, and decrease of bacterial richness toward relapse were observed for UC patients, whereas the MAF for controls was stable over time.
Ott
Stephan J
SJ
Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, Schittenhelmstr. 12, 24105 Kiel, Germany.
Plamondon
Sophie
S
Hart
Ailsa
A
Begun
Alexander
A
Rehman
Ateequr
A
Kamm
Michael A
MA
Schreiber
Stefan
S
D000328:Adult; D044822:Biodiversity; D003093:Colitis, Ulcerative / Q000382:microbiology* / Q000517:prevention & control; D003106:Colon / Q000382:microbiology*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012008:Recurrence; D017422:Sequence Analysis, DNA
D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S