The chicken major histocompatibility complex and resistance to Rous sarcoma virus tumours.
Chickens from an Australorp line which had two major histocompatibility complex (MHC) alleles, B3A and B(9A) , segregating within the line, were inoculated with Rous sarcoma virus and the resulting tumours were monitored over time. In the majority of chickens possessing the B8A allele, the developing tumours regressed, while in all chickens without B8A allele (i.e. B 9A/9A homozygotes) the tumours progressed and eventually led to their death.
Loudovaris
T
T
CSIRO, Division of Animal Health, Animal Health Research Laboratory, Parkville, Vic., Australia.
Ignjatovic
J
J
Fahey
K J
KJ