Absence of association between a functional polymorphism of ALOX15 gene and infertility in endometriosis.
The aim of the present study, involving 463 women of reproductive age, was to evaluate for the first time the relationship between endometriosis, endometriosis-related infertility, and a recently described functional polymorphism in the ALOX15 gene, reported to be essential for implantation. In our study population, ALOX15 -292 C/T was not correlated either with the risk of developing an endometriosis or with the risk of infertility.
Borghese
Bruno
B
Service de Gynécologie-Obstétrique II et Médecine de la Reproduction, Université Paris Descartes, Assistance Publique-Hôpitaux de Paris, CHU Cochin - Saint Vincent de Paul, Paris, France. bruno.borghese@inserm.fr
Gayet
Vanessa
V
Chiche
Jean-Daniel
JD
Vernerey
Déwi
D
de Ziegler
Dominique
D
Bonaiti-Pellié
Catherine
C
Chapron
Charles
C
D001093:Arachidonate 15-Lipoxygenase / Q000235:genetics*; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007247:Infertility, Female / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
C515716:ALOX15 protein, human; D001093:Arachidonate 15-Lipoxygenase