Oxidized low-density lipoprotein and oxidative stress in the development of glomerulosclerosis.
Glomerulosclerosis frequently complicates most renal diseases and is characterized by mesangial matrix accumulation. Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the pathogenetic mechanisms of lipid-mediated glomerulosclerosis, emphasizing the fibrogenic signaling cascades triggered by Ox-LDL. In addition, therapeutic strategies to prevent the development of Ox-LDL-mediated glomerulosclerosis will be discussed.
Lee
Hyun Soon
HS
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea. hyunsoon@plaza.snu.ac.kr
Song
Chi Young
CY
D000975:Antioxidants / Q000378:metabolism; D004789:Enzyme Activation; D005921:Glomerulonephritis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D050527:Mesangial Cells / Q000378:metabolism / Q000473:pathology; D019255:NADPH Oxidases / Q000378:metabolism; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D012084:Renin-Angiotensin System; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism
D000975:Antioxidants; D008077:Lipoproteins, LDL; D016212:Transforming Growth Factor beta; C099252:oxidized low density lipoprotein; D019255:NADPH Oxidases; D011493:Protein Kinase C; D010100:Oxygen