Predictive value of natriuretic peptides in dogs with mitral valve disease.
Natriuretic peptides are useful in diagnosing heart failure in dogs. However, their usefulness in detecting early stages of myxomatous mitral valve disease (MMVD) has been debated. This study evaluated N-terminal (NT) fragment pro-atrial natriuretic peptide (NT-proANP) and NT-pro-brain natriuretic peptide (NT-proBNP) in 39 Cavalier King Charles Spaniels (CKCS) with pre-clinical mitral valve regurgitation (MR), sixteen dogs with clinical signs of heart failure (HF) and thirteen healthy control dogs. Twenty seven CKCS and ten control dogs were re-examined 4 years after the initial examination and the status of the dogs 5 years after the initial examination was determined by telephone calls to the owner. All dogs were evaluated by clinical examination and echocardiography. CKCS with severe MR had higher NT-proANP and NT-proBNP compared to controls and CKCS with less severe MR. Dogs with clinical signs of HF had markedly elevated NT-proANP and NT-proBNP. Plasma concentrations of the natriuretic peptides measured at re-examination could predict progression in regurgitant jet size.
Tarnow
Inge
I
Department of Basic Animal and Veterinary Sciences, The Faculty of Life Sciences, University of Copenhagen, 7 Gronnegaardsvej, DK-1870 Frederiksberg C, Denmark. int@life.ku.dk
Olsen
Lisbeth H
LH
Kvart
Clarence
C
Hoglund
Katja
K
Moesgaard
Sophia G
SG
Kamstrup
Thea S
TS
Pedersen
Henrik D
HD
Häggström
Jens
J
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood*; D004283:Dog Diseases / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D008297:Male; D008944:Mitral Valve Insufficiency / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011237:Predictive Value of Tests
D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor