title: Immunologic and biochemical factors of coincident celiac disease and type 1 diabetes mellitus in children.
abstract: The objective of the study was to investigate whether immunologic and biochemical events occurring in the course of type 1 diabetes mellitus might play a role in the development of the celiac disease. The study was carried out on 223 children with long-standing diabetes mellitus type 1 (DM1). All the patients had TSH, fT4, fT3, urinary albumin secretion rate, IgA, level of antigliadin antibodies (AGA) IgA and IgG, antitissue transglutaminase IgA antibodies, antiendomysium (EmA) IgA and IgG antibodies and antitireoglobulin antibodies, antithyroid peroxidase antibodies evaluated. Serum TNF-alpha, IL-6, and IL-10 levels were also measured. The group of children with coincident DM1 and celiac disease and without autoimmune thyroiditis was characterized by significantly higher glycosylated hemoglobin, higher serum TNF-alpha, IL-6 but lower serum IL-10 in relation to the remaining diabetic patients. A statistically significant positive correlation was observed between IgA-anti-tTG and serum TNF-alpha (R = 0.28, p = 0.026); between IgG AGA and serum IL-6 (R = 0.31, p = 0.023); and between glycosylated hemoglobin and IgA-anti-tTG (R = 0.21, p = 0.001) and IgA antiendomysium (R = 0.22, p = 0.001). Poor metabolic control, persistent elevated levels of proinflammatory cytokines, and decreased level of antiinflammatory cytokines occurring in the course of type 1 diabetes mellitus might influence the incidence of celiac disease.
authors.affiliation: Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdańsk, 80-952 Gdańsk, Poland. mysliwiec@amg.gda.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Myśliwiec
authors.forename: Anna
authors.initials: A
authors.lastname: Balcerska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Zorena
authors.forename: Jolanta
authors.initials: J
authors.lastname: Myśliwska
authors.forename: Piotr
authors.initials: P
authors.lastname: Wiśniewski
mesh_terms: D000293:Adolescent; D002446:Celiac Disease / Q000097:blood* / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D002648:Child; D015897:Comorbidity; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology; D008297:Male; D012680:Sensitivity and Specificity; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000276:immunology
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10