title: Physiochemical drug properties associated with in vivo toxicological outcomes.
abstract: Relationships between physicochemical drug properties and toxicity were inferred from a data set consisting of animal in vivo toleration (IVT) studies on 245 preclinical Pfizer compounds; an increased likelihood of toxic events was found for less polar, more lipophilic compounds. This trend held across a wide range of types of toxicity and across a broad swath of chemical space.
authors.affiliation: Pfizer Research Technology Center, Cambridge, MA 02139, USA.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Hughes
authors.forename: Julian
authors.initials: J
authors.lastname: Blagg
authors.forename: David A
authors.initials: DA
authors.lastname: Price
authors.forename: Simon
authors.initials: S
authors.lastname: Bailey
authors.forename: Gary A
authors.initials: GA
authors.lastname: Decrescenzo
authors.forename: Rajesh V
authors.initials: RV
authors.lastname: Devraj
authors.forename: Edmund
authors.initials: E
authors.lastname: Ellsworth
authors.forename: Yvette M
authors.initials: YM
authors.lastname: Fobian
authors.forename: Michael E
authors.initials: ME
authors.lastname: Gibbs
authors.forename: Richard W
authors.initials: RW
authors.lastname: Gilles
authors.forename: Nigel
authors.initials: N
authors.lastname: Greene
authors.forename: Enoch
authors.initials: E
authors.lastname: Huang
authors.forename: Teresa
authors.initials: T
authors.lastname: Krieger-Burke
authors.forename: Jens
authors.initials: J
authors.lastname: Loesel
authors.forename: Travis
authors.initials: T
authors.lastname: Wager
authors.forename: Larry
authors.initials: L
authors.lastname: Whiteley
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D004364:Pharmaceutical Preparations