Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis.
The risk of thromboembolism is increased in inflammatory bowel disease and its symptoms may be overlooked. Furthermore, its treatment can be complex and is not without complications. We describe a case of an adolescent boy who developed a cerebral sinus venous thrombosis during a relapse of his ulcerative colitis and who, while on treatment with heparin, developed heparin-induced thrombocytopenia (HIT). The treatment was then switched to fondaparinux, a synthetic and selective inhibitor of activated factor X.
Thorsteinsson
Gudrun Scheving
GS
Division of Paediatric Gastroenterology, Hepatology & Nutrition, B57 Karolinska University Hospital Stockholm Se-141 86, Sweden.
Magnussson
Maria
M
Hallberg
Lena M
LM
Wahlgren
Nils Gunnar
NG
Lindgren
Fredrik
F
Malmborg
Petter
P
Casswall
Thomas H
TH
D000293:Adolescent; D003093:Colitis, Ulcerative / Q000150:complications*; D000077425:Fondaparinux; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D020767:Intracranial Thrombosis / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D011134:Polysaccharides / Q000627:therapeutic use; D012307:Risk Factors; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis; D020246:Venous Thrombosis / Q000188:drug therapy* / Q000453:epidemiology
D011134:Polysaccharides; D006493:Heparin; D000077425:Fondaparinux