Immunohistochemical findings in rectal duplication mimicking rectal prolapse.
Alimentary tract duplications represent rare anomalies, with only 5 % occurring in the rectum. The variety in clinical presentation may lead to a delay in diagnosis or to incorrect and multiple surgical procedures. We report the clinical, histological and immunohistochemical characteristics of a rectal duplication occurring in a 3-month-old male with an unusual clinical presentation. Using routine histology and immunohistochemistry, the rectal duplication showed the diffuse presence of gastric mucosa with a characteristic immunophenotype (i.e., diffuse cytokeratin 7 positivity and scattered chromogranin immunoreactivity). As far as we know, this is the first report showing an immunohistochemical differentiation pattern of gastric lining in a rectal duplication. Our results, showing the presence of gastric mucosa, are suggestive of a possible origin from the embryonic foregut.
Cortese
M G
MG
Department of Pediatric Surgery, Regina Margherita Children's Hospital, Turin, Italy.
Pucci
A
A
Macchieraldo
R
R
Sacco Casamassima
M G
MG
Canavese
F
F
D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D053554:Keratin-20 / Q000378:metabolism; D053552:Keratin-7 / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D012005:Rectal Prolapse / Q000378:metabolism*; D012007:Rectum / Q000002:abnormalities*
D053554:Keratin-20; D053552:Keratin-7