title: TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype.
abstract: Presence of TP53 mutations has been associated with poor prognosis in diffuse large B-cell lymphoma (DLBCL), although this has remained controversial. The TP53 codon 72 polymorphism has shown negative impact on cancer survival, but this has not been analyzed in DLBCL. Furthermore, the MDM2 SNP309 has been associated with earlier age of onset in DLBCL. Here, we investigated the clinical impact of TP53 mutations, MDM2 SNP309 and TP53 codon 72 polymorphisms on survival in DLBCL of germinal center (GC) and non-GC subtypes. Thirteen of the 102 (12.7%) patients displayed TP53 mutations. Overall, TP53 mutations had a significant effect on lymphoma-specific survival (LSS, P=0.009) and progression-free survival (PFS, P=0.028). In particular, inferior survival was observed in TP53-mutated DLBCLs of GC subtype (LSS, P=0.002 and PFS, P=0.006). Neither MDM2 SNP309 nor the TP53 codon 72 polymorphism had an impact on age of onset or survival. Altogether, our data suggests that TP53 mutations are associated with poor outcome in GC-DLBCL patients.
authors.affiliation: Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden.
authors.forename: Norafiza
authors.initials: N
authors.lastname: Zainuddin
authors.forename: Mattias
authors.initials: M
authors.lastname: Berglund
authors.forename: Alkwin
authors.initials: A
authors.lastname: Wanders
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Ren
authors.forename: Rose-Marie
authors.initials: RM
authors.lastname: Amini
authors.forename: Monica
authors.initials: M
authors.lastname: Lindell
authors.forename: Meena
authors.initials: M
authors.lastname: Kanduri
authors.forename: Göran
authors.initials: G
authors.lastname: Roos
authors.forename: Richard
authors.initials: R
authors.lastname: Rosenquist
authors.forename: Gunilla
authors.initials: G
authors.lastname: Enblad
mesh_terms: D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D009154:Mutation; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53