title: [Treatment of advanced penile cancer. Do we need new methods for chemotherapy?].
abstract: Penile cancer is a squamous epithelial neoplasia with a very high mortality in advanced stages. Only few series with small patient numbers have addressed the systemic treatment of advanced penile carcinoma. Established regimens are characterized by high toxicity and poor efficacy. Due to the relative paucity of data, recommendations and guidelines on the treatment of metastatic penile carcinoma are vague. New approaches and large-scale studies that will allow better definition of adequate and more effective treatment options are needed. Encouraging results with newer chemotherapeutic agents are at present mainly anecdotal but are still encouraging.
authors.affiliation: Klinik und Poliklinik für Urologie, Universität Rostock, Rostock, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Protzel
authors.forename: H-J
authors.initials: HJ
authors.lastname: Klebingat
authors.forename: O W
authors.initials: OW
authors.lastname: Hakenberg
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D018450:Disease Progression; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects; D010166:Palliative Care; D010412:Penile Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D001761:Bleomycin; D003520:Cyclophosphamide; D016190:Carboplatin; D017239:Paclitaxel; D008727:Methotrexate