title: Niacin for dairy cattle: a review.
abstract: Due to the incorporation of niacin into the coenzymes NAD and NADP, niacin is of great importance for the metabolism of man and animals. Apart from niacin in feed and endogenous formation, microbial niacin synthesis in the rumen is an important source for dairy cows. But the amount synthesised seems to differ greatly, which might be influenced by the ration fed. Many studies revealed a positive impact of a niacin supplementation on rumen protozoa, but microbial protein synthesis or volatile fatty acid production in the rumen showed inconsistent reactions to supplemental niacin. The amount of niacin reaching the duodenum is usually higher when niacin is fed. However, not the whole quantity supplemented reaches the duodenum, indicating degradation or absorption before the duodenal cannula. Furthermore, supplementation of niacin did not always lead to a higher niacin concentration in blood. Effects on other blood parameters have been inconsistent, but might be more obvious when cows are in a tense metabolic situation, for example, ketosis or if high amounts are infused post-ruminally, since ruminal degradation appears to be substantial. The same is valid for milk parameters. In the few studies where blood niacin and milk parameters have been investigated, enhanced niacin concentrations in blood did not necessarily affect milk production or composition. These results are discussed in the present review, gaps of knowledge of niacin's mode of action on the metabolism of dairy cows are identified and directions for future research are suggested.
authors.affiliation: Institute of Animal Nutrition, Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Bundesallee 50, 38116 Braunschweig, Germany. inka.niehoff@fli.bund.de
authors.forename: Inka-Donata
authors.initials: ID
authors.lastname: Niehoff
authors.forename: Liane
authors.initials: L
authors.lastname: Hüther
authors.forename: Peter
authors.initials: P
authors.lastname: Lebzien
mesh_terms: D000824:Animal Nutritional Physiological Phenomena / Q000187:drug effects*; D000818:Animals; D002417:Cattle / Q000378:metabolism*; D019587:Dietary Supplements; D004386:Duodenum / Q000378:metabolism; D008892:Milk / Q000737:chemistry; D009525:Niacin / Q000493:pharmacokinetics / Q000494:pharmacology*; D012417:Rumen / Q000378:metabolism
chemical_list: D009525:Niacin