title: [Coagulation management of severe surgical bleeding].
abstract: Severe intraoperative bleeding may endanger the patient's life, necessitate additional human resources and increase perioperative costs. The aetiology of perioperative coagulopathy is complex and consists of depletion, consumption and dilution of clotting factors and thrombocytes. Cofactors like hypothermia, acidosis and severe anaemia may aggravate coagulopathy. Previously healthy patients often show hypofibrinogenaemia as the primary trigger of coagulopathy, whereas thrombocytopenia rather is a late event during massive bleeding. Early and differentiated diagnosis is essential for initiating targeted therapy. Evaluation of the clinical bleeding situation and coagulation tests, in particular point-of-care testing like thrombelastography, should be used to guide and control the therapeutic strategy. Fresh frozen plasma, concentrates of clotting factors, platelet concentrates and antifibrinolytic drugs are available for therapy of perioperative coagulopathy. To obtain optimal benefit for the patient, these products should be applied based on a therapeutic algorithm.
authors.affiliation: Klinik für Anaesthesiologie, Klinikum der Ludwig Maximilians Universität, Nussbaumstrasse 20, 80336 München. Bernhard.Heindl@med.uni-muenchen.de
authors.forename: B
authors.initials: B
authors.lastname: Heindl
authors.forename: P
authors.initials: P
authors.lastname: Biberthaler
mesh_terms: D003029:Coagulants / Q000008:administration & dosage*; D006801:Humans; D010949:Plasma; D019106:Postoperative Hemorrhage / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D003029:Coagulants