Repellency property of long chain aliphatic methyl ketones against Anopheles gambiae s.s.
Long chain aliphatic methyl ketone series of C7-C15 were tested for repellency activity against the malaria transmitting mosquito Anopheles gambiae s.s. All methyl ketones produced a dose dependent (P < 0.001) repellency response with 2-tridecanone giving comparable protection efficacy to DEET at 10% and 1% concentrations. Aliphatic methyl ketones of C7-C10 had lower activity than those of C11-C15. However, within this range compounds with odd carbon atoms (2-undecanone, 2-tridecanone and 2-pentadecanone) were more effective than compounds with even carbon atoms (2-decanone and 2- dodecanone). Comparable repellency activity of 2-tridecanone to DEET show that, it may save as Anopheles gambiae s.s. mosquito repellent.
Innocent
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Muhimbili University of Health & Allied Sciences, Institute of Traditional Medicine, P.O. Box 65001, Dar es Salaam, Tanzania. innocent@chem.udsm.ac.tz
Gikonyo
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Nkunya
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MH
D000818:Animals; D000852:Anopheles / Q000187:drug effects*; D003671:DEET / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007302:Insect Repellents / Q000494:pharmacology*; D007303:Insect Vectors / Q000187:drug effects*; D007659:Ketones / Q000737:chemistry / Q000494:pharmacology*
D007302:Insect Repellents; D007659:Ketones; D003671:DEET