title: Prioritizing Disease Genes by Analysis of Common Elements (PDG-ACE).
abstract: Complex diseases are characterized by multiple genetic and environmental influences on disease susceptibility. Since the multiple genetic influences converge on a single phenotype, some commonality may be evident among genes that influence the disease. We exploit this potential commonality among candidate disease genes to prioritize genes for further analysis and to pose novel, statistically significant, biologically plausible hypotheses on disease etiology.
authors.affiliation: University of Mich., Ann Arbor, MI, USA.
authors.forename: Richard C
authors.initials: RC
authors.lastname: McEachin
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Keller
authors.forename: Peter P
authors.initials: PP
authors.lastname: Zandi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Almani
authors.forename: Melvin G
authors.initials: MG
authors.lastname: McInnis
mesh_terms: D000465:Algorithms; D001714:Bipolar Disorder / Q000235:genetics*; D030541:Databases, Genetic; D020022:Genetic Predisposition to Disease; D006801:Humans; D010641:Phenotype; D013358:Subject Headings; D018875:Vocabulary, Controlled