title: Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials.
abstract: An efficient synthesis of two new N-acetyl-4'-arylphenylalanines is described together with their incorporation into a number of cationic peptoid antibacterial agents, one of which had an MIC of 7.8 microg/mL against Staphylococcus aureus.
authors.affiliation: School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Boyle
authors.forename: John B
authors.initials: JB
authors.lastname: Bremner
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Coates
authors.forename: John
authors.initials: J
authors.lastname: Deadman
authors.forename: Paul A
authors.initials: PA
authors.lastname: Keller
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Pyne
authors.forename: Kittiya
authors.initials: K
authors.lastname: Somphol
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010649:Phenylalanine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D010649:Phenylalanine