Comparative study of pharmacological activity of afala on the model of hormone-induced prostatitis in rats.
Afala (ultralow-dose antibodies to prostate-specific antigen) injected for 60 days to rats with hormone-induced prostatitis caused by sulpiride prevented the development of prostatic hyperplasia and reduced the severity of histological changes. The effect of Afala was superior to that of the reference drug (Serenoa repens extract).
Savelieva
K V
KV
Materia Medical Holding, Moscow. savelievakv@materiamedica.ru
Borovskaya
T G
TG
Kheyfets
I A
IA
Dugina
J L
JL
Sergeeva
S A
SA
Epstein
O I
OI
D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D004195:Disease Models, Animal; D007124:Immunoenzyme Techniques; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D011388:Prolactin / Q000097:blood; D011467:Prostate / Q000187:drug effects / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000276:immunology*; D011470:Prostatic Hyperplasia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D011472:Prostatitis / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D028024:Serenoa / Q000737:chemistry; D013469:Sulpiride
D000906:Antibodies; D010936:Plant Extracts; C533336:afala; D013469:Sulpiride; D011388:Prolactin; D017430:Prostate-Specific Antigen