title: Apatite formation abilities and mechanical properties of hydroxyethylmethacrylate-based organic-inorganic hybrids incorporated with sulfonic groups and calcium ions.
abstract: Apatite formation in the living body is an essential requirement for artificial materials to exhibit bone-bonding bioactivity. It has been recently revealed that sulfonic groups trigger apatite nucleation in a body environment. Organic-inorganic hybrids consisting of organic polymers and the sulfonic groups are therefore expected to be useful for preparation of novel bone-repairing materials exhibiting flexibility as well as bioactivity. In the present study, organic-inorganic hybrids were prepared from hydroxyethylmethacrylate (HEMA) in the presence of vinylsulfonic acid sodium salt (VSAS) and calcium chloride (CaCl(2)). The bioactivities of the hybrids were assessed in vitro by examining the apatite formation in simulated body fluid (SBF, Kokubo solution). The hybrids deposited on the apatite after soaking in SBF within 7 days. Tensile strength measurements showed a tendency to increase with increases in VSAS and CaCl(2) content. It was assumed that this phenomenon was attributed to the formation of cross-linking in the hybrids.
authors.affiliation: Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu-shi, Fukuoka, 808-0196, Japan. tmiya@life.kyutech.ac.jp
authors.forename: Toshiki
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Moriyoshi
authors.initials: M
authors.lastname: Imamura
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ishida
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ashizuka
authors.forename: Chikara
authors.initials: C
authors.lastname: Ohtsuki
mesh_terms: D001031:Apatites / Q000737:chemistry*; D001696:Biomechanical Phenomena; D018786:Bone Substitutes / Q000138:chemical synthesis / Q000737:chemistry*; D002122:Calcium Chloride / Q000737:chemistry; D005030:Ethylenes / Q000737:chemistry; D066298:In Vitro Techniques; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D013451:Sulfonic Acids / Q000737:chemistry; D013499:Surface Properties; D013718:Tensile Strength; D014961:X-Ray Diffraction
chemical_list: D001031:Apatites; D018786:Bone Substitutes; D005030:Ethylenes; D008689:Methacrylates; D013451:Sulfonic Acids; C005044:hydroxyethyl methacrylate; C085726:ethylenesulfonic acid; D002122:Calcium Chloride