title: Clarithromycin inhibits fibroblast migration.
abstract: The aim of the current study was to investigate the effect of 14-membered ring macrolide clarithromycin (CAM) on migration induced by human plasma fibronectin (HFn) or on contraction of human fetal lung fibroblasts (HFL-1).
  
  
  RESULTS
  Using the blindwell chamber technique, CAM (10(-5) M) inhibited the migration of HFL-1 60.2+/-4.0% (p<0.05). Other antibiotics, such as ampicillin, minocycline or azithromycin had no effects on HFL-1 migration. The effect of CAM was concentration dependent. HFL-1 migration, stimulated by TXA(2) analog was also inhibited by CAM. Clarithromycin had no effect on HFL-1 mediated gel contraction that was another function of fibroblast at the wound area.
  
  
  CONCLUSIONS
  Clarithromycin may contribute to the regulation of the wound healing response following injury by inhibiting fibroblast migration. These results could represent the therapeutic benefits of CAM.
authors.affiliation: Department of Respiratory Medicine, The University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8655, Japan. koyama-tky@umin.ac.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kohyama
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamauchi
authors.forename: Hajime
authors.initials: H
authors.lastname: Takizawa
authors.forename: Susumu
authors.initials: S
authors.lastname: Itakura
authors.forename: Sumiko
authors.initials: S
authors.lastname: Kamitani
authors.forename: Jun
authors.initials: J
authors.lastname: Kato
authors.forename: Takahide
authors.initials: T
authors.lastname: Nagase
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects*; D017291:Clarithromycin / Q000494:pharmacology*; D003094:Collagen / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects* / Q000502:physiology; D005353:Fibronectins / Q000494:pharmacology; D005782:Gels; D006801:Humans; D008168:Lung / Q000166:cytology
chemical_list: D000900:Anti-Bacterial Agents; D005353:Fibronectins; D005782:Gels; D003094:Collagen; D017291:Clarithromycin