title: A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes.
abstract: We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module.
authors.affiliation: MRC Centre for Protein Engineering, Cambridge, UK. tony@mrc-lmb.cam.ac.uk
authors.forename: Antonina
authors.initials: A
authors.lastname: Andreeva
authors.forename: Henning
authors.initials: H
authors.lastname: Tidow
mesh_terms: D001665:Binding Sites; D017124:Conserved Sequence; D006801:Humans; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D012343:RNA, Transfer / Q000737:chemistry / Q000235:genetics; D017411:Ribonucleoproteins, Small Nuclear / Q000737:chemistry*; D017381:Spliceosomes / Q000378:metabolism*; D016335:Zinc Fingers; D012359:tRNA Methyltransferases / Q000737:chemistry*
chemical_list: D017411:Ribonucleoproteins, Small Nuclear; C552126:U11-U12 small nuclear ribonucleoprotein; D012343:RNA, Transfer; D012359:tRNA Methyltransferases