title: Predictive value of natriuretic peptides in dogs with mitral valve disease.
abstract: Natriuretic peptides are useful in diagnosing heart failure in dogs. However, their usefulness in detecting early stages of myxomatous mitral valve disease (MMVD) has been debated. This study evaluated N-terminal (NT) fragment pro-atrial natriuretic peptide (NT-proANP) and NT-pro-brain natriuretic peptide (NT-proBNP) in 39 Cavalier King Charles Spaniels (CKCS) with pre-clinical mitral valve regurgitation (MR), sixteen dogs with clinical signs of heart failure (HF) and thirteen healthy control dogs. Twenty seven CKCS and ten control dogs were re-examined 4 years after the initial examination and the status of the dogs 5 years after the initial examination was determined by telephone calls to the owner. All dogs were evaluated by clinical examination and echocardiography. CKCS with severe MR had higher NT-proANP and NT-proBNP compared to controls and CKCS with less severe MR. Dogs with clinical signs of HF had markedly elevated NT-proANP and NT-proBNP. Plasma concentrations of the natriuretic peptides measured at re-examination could predict progression in regurgitant jet size.
authors.affiliation: Department of Basic Animal and Veterinary Sciences, The Faculty of Life Sciences, University of Copenhagen, 7 Gronnegaardsvej, DK-1870 Frederiksberg C, Denmark. int@life.ku.dk
authors.forename: Inge
authors.initials: I
authors.lastname: Tarnow
authors.forename: Lisbeth H
authors.initials: LH
authors.lastname: Olsen
authors.forename: Clarence
authors.initials: C
authors.lastname: Kvart
authors.forename: Katja
authors.initials: K
authors.lastname: Hoglund
authors.forename: Sophia G
authors.initials: SG
authors.lastname: Moesgaard
authors.forename: Thea S
authors.initials: TS
authors.lastname: Kamstrup
authors.forename: Henrik D
authors.initials: HD
authors.lastname: Pedersen
authors.forename: Jens
authors.initials: J
authors.lastname: Häggström
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood*; D004283:Dog Diseases / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D008297:Male; D008944:Mitral Valve Insufficiency / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011237:Predictive Value of Tests
chemical_list: D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor