title: The in vitro anti-osteoporotic activity of some diarylheptanoids and lignans from the rhizomes of Dioscorea spongiosa.
abstract: Three diarylheptanoids and three lignans from the 90 % ethanol fraction of the rhizomes of DIOSCOREA SPONGIOSA were isolated and subjected to IN VITRO experiments to investigate their activity on osteoblasts and osteoclasts. Diarylheptanoid 1 and furofuran lignan 6 were found to significantly stimulate the proliferation of primary osteoblasts and 6 also mildly stimulated osteoblast mineralization by mouse calvaria osteoblastic cells. All diarylheptanoids and lignans at a concentration of 200 muM completely inhibited the formation of osteoclast-like cells. These results demonstrate that the isolated diarylheptanoids and lignans in the 90 % ethanol fraction have significant anti-osteoporotic activities.
authors.affiliation: Department of Pharmacognosy, Shenyang Pharmaceutical University, Shenyang, PR China. yinjun2002@yahoo.com
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.forename: Na
authors.initials: N
authors.lastname: Han
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Liu
authors.forename: Xinyang
authors.initials: X
authors.lastname: Xu
authors.forename: Baoyan
authors.initials: B
authors.lastname: Zhang
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Kadota
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D036381:Diarylheptanoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D027742:Dioscorea / Q000737:chemistry*; D005260:Female; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D010006:Osteoblasts / Q000187:drug effects*; D010010:Osteoclasts / Q000187:drug effects*; D027343:Rhizome / Q000737:chemistry*
chemical_list: D036381:Diarylheptanoids; D017705:Lignans