title: Gynandroblastoma. Report of an unusual ovarian tumour and literature review.
abstract: Gynandroblastoma is a rare variant of ovarian sex cord stromal tumours that demonstrates morphological evidence of both male and female differentiation. We report a new case of gynandroblastoma in a 22-year-old nulliparous female with a history of menstrual disturbance. Physical examination disclosed a painless pelvic mass measuring 20 cm across with normal secondary sex characteristics, and no signs of virilisation. Histological examination of the surgically resected primary tumour revealed a predominant adult granulosa cell component admixed with a minor Sertoli cell component that did not exceed 20% of the tumour. Immunohistochemical analysis showed positive immunostaining of Sertoli cell areas with inhibin. The final diagnosis was gynandroblastoma. The post-operative course was uneventful and there was no evidence of recurrence during the 9-month follow-up period.
authors.affiliation: Department of Pathology, Mongi Slim Hospital, Sidi Daoued La Marsa (2046), Tunisia. fatenlimaiem@yahoo.fr
authors.forename: F
authors.initials: F
authors.lastname: Limaïem
authors.forename: A
authors.initials: A
authors.lastname: Lahmar
authors.forename: C
authors.initials: C
authors.lastname: Ben Fadhel
authors.forename: S
authors.initials: S
authors.lastname: Bouraoui
authors.forename: S
authors.initials: S
authors.lastname: M'zabi-Regaya
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology*; D018312:Sex Cord-Gonadal Stromal Tumors / Q000473:pathology*