title: Adiponectin is associated with lipid profile and insulin sensitivity in French adolescents.
abstract: OBJECTIVE
  The favourable relationship of adiponectin with the metabolic profile demonstrated in adults has been less studied in youths. The aim of this study was to examine cross-sectional and longitudinal associations between adiponectin and various metabolic risk factors in 12-year-old adolescents.
  
  
  METHODS
  Subjects were participants in a randomized controlled study to promote physical activity (PA). Cross-sectional associations were assessed at entry in 2002 among 647 PA-exposed and control first-level students (49% male, 11.6+/-0.6 years of age). Longitudinal analyses involved 288 control students surveyed in 2002 and 2004. Baseline measurements included fasting serum adiponectin and anthropometric indices (body mass, waist size, body fat [BF] by bioimpedance), insulin concentration, homeostasis model assessment (HOMA), high-density lipoprotein (HDL) cholesterol, triglycerides (TG), soluble TNF-alpha receptor 1 (sTNF-alpha R1) and high-sensitivity C-reactive protein. Analyses were performed with generalized linear mixed-effects models, taking into account correlations among adolescents in the same school.
  
  
  RESULTS
  Cross-sectionally, plasma adiponectin was inversely associated with obesity indices, especially waist size (P<10(-2)), HOMA (P<0.03), insulin (P<0.04), TG (P<10(-2)) and sTNF-alpha R1 (P<0.05), and positively related to HDL cholesterol (P<10(-4)), after adjusting for age, gender, sexual maturity, sports participation and adiposity when relevant. Longitudinally, a higher baseline adiponectin level was associated with a more favourable two-year change in TG (P<0.05), even after accounting for baseline TG, and two-year BF and insulin changes.
  
  
  CONCLUSIONS
  The findings of this study suggest a favourable relationship between adiponectin and both metabolic profile and subsequent changes in TG level in young adolescents.
authors.affiliation: Louis Pasteur University of Strasbourg, Medical Faculty, EA 1801, 67000 cedex Strasbourg, France.
authors.forename: A
authors.initials: A
authors.lastname: Wagner
authors.forename: C
authors.initials: C
authors.lastname: Simon
authors.forename: M
authors.initials: M
authors.lastname: Oujaa
authors.forename: C
authors.initials: C
authors.lastname: Platat
authors.forename: B
authors.initials: B
authors.lastname: Schweitzer
authors.forename: D
authors.initials: D
authors.lastname: Arveiler
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000273:Adipose Tissue / Q000033:anatomy & histology; D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008019:Life Style; D008137:Longitudinal Studies; D008297:Male; D012741:Sexual Maturation; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D008076:Cholesterol, HDL; D007328:Insulin; D020738:Leptin; D014280:Triglycerides