title: Interstitial granulomatous dermatitis: a misdiagnosed cutaneous form of systemic lupus erythematosus?
abstract: Interstitial granulomatous dermatitis (IGD) is a recently described, rare dermatological entity. The clinical features are diverse and the precise aetiology is unknown. We present a rare and atypical case of IGD in a patient with systemic lupus erythematosus (SLE). A 26-year-old woman had been diagnosed with SLE when she was 15 years old. The diagnosis was based on cutaneous, articular, pulmonary, haematological and immunological features. The patient presented with a cutaneous diffuse macular eruption on the limbs, appearing in a cockade (rosette) pattern with a violaceous centre and erythematous surround. The face and trunk were spared. The cutaneous histological features led us to consider a diagnosis of IGD. The lesions disappeared after 15 days of systemic steroid therapy. This case is a new clinical form of IGD with an atypical location and clinical presentation. IGD has usually been associated with drug-related adverse reactions and autoimmune diseases. Reports in the literature of IGD in patients with SLE are rare.
authors.affiliation: Department of Vascular Medicine, Grenoble University Hospital, Grenoble, France. sblaise@chu-grenoble.fr
authors.forename: S
authors.initials: S
authors.lastname: Blaise
authors.forename: D
authors.initials: D
authors.lastname: Salameire
authors.forename: P H
authors.initials: PH
authors.lastname: Carpentier
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D003872:Dermatitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D012867:Skin / Q000473:pathology*; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D014859:Warfarin; D011239:Prednisolone; D001379:Azathioprine