Potentiation of the anticoccidial effect of salinomycin with dihydroquinoline-type antioxidants.
The potentiating efficacy was determined on day 8 after infection with Eimeria tenella on the basis of oocyst counts and gross caecal lesions. The prototype of dihydroquinoline-type antioxidants (6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline) had no potentiating effect. When two molecules of the prototype were linked with an alkyl group (methylidene, ethylidene, or propylidene), the anticoccidial efficacy of salinomycin was increased such that a dose of 15 mg/kg was as effective as the standard 60 mg/kg given alone. The potentiating effect was lost if the molecule were acetylated or sulphonated. A similar potentiating effect was also demonstrable for monensin but was lacking for lasalocid.
Prohaszka
L
L
Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest, Hungary.
Rozsnyai
T
T