Ocular neuromyotonia in a 15-year-old girl after radiation therapy.
A 15-year-old girl, previously treated with radiation, chemotherapy, and surgery for a posterior fossa medulloblastoma and parasellar metastasis at age 8, presented with a 10-month history of episodic horizontal diplopia. She was diagnosed with ocular neuromyotonia and successfully treated with oral carbamazepine. Given the strong association between peripheral neuromyotonia and the presence of autoimmune antivoltage-gated potassium channels, the patient's blood was tested and found negative for these autoantibodies. This is the first time this has been verified in a person with ocular neuromyotonia.
de Saint Sardos
Alexandre
A
Department of Pediatric Ophthalmology, Le Centre Hospitalier Universitaire Mère-Enfant Sainte-Justine, University of Montreal, Montreal, Canada.
Vincent
Angela
A
Aroichane
Maryam
M
Ospina
Luis H
LH
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D002220:Carbamazepine / Q000627:therapeutic use; D002528:Cerebellar Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D003388:Cranial Fossa, Posterior; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020386:Isaacs Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D008527:Medulloblastoma / Q000532:radiotherapy* / Q000556:secondary; D015835:Ocular Motility Disorders / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D010911:Pituitary Neoplasms / Q000532:radiotherapy; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology; D011832:Radiation Injuries / Q000150:complications*; D012658:Sella Turcica
D001323:Autoantibodies; D024642:Potassium Channels, Voltage-Gated; D002220:Carbamazepine