title: Moderate physical training increases brain insulin concentrations in experimental diabetic rats.
abstract: Insulin is an important modulator of growth and metabolic function in the central nervous system. The aim of this study was to investigate the influence of swimming physical training (at 32 degrees +/- 1 degree C, 1 hr/day, 5 days/week, with an overload equivalent to 5% of the body weight, for 4 weeks) on brain insulin concentrations in alloxan induced type 1 diabetic rats. Training attenuated hyperglycemia but had no effect on insulinemia in diabetic rats. Hematocrit and blood albumin values remained without changes. Brain insulin did not change in diabetic rats. However, physical training increased the concentration in both control and diabetic rats. It is concluded that in the present experimental conditions, diabetes had no influence on brain insulin, however moderate physical training increased the hormone in both control and diabetic animals.
authors.affiliation: Department of Physical Education, São Paulo State University, Bela Vista, CEP 13506-900, Rio Claro, São Paulo, Brazil. zecuriacos@terra.com.br
authors.forename: José Alexandre Curiacos de Almeida
authors.initials: JA
authors.lastname: Leme
authors.forename: Ricardo José
authors.initials: RJ
authors.lastname: Gomes
authors.forename: Maria Alice Rostom
authors.initials: MA
authors.lastname: de Mello
authors.forename: Eliete
authors.initials: E
authors.lastname: Luciano
mesh_terms: D000818:Animals; D001786:Blood Glucose; D001921:Brain / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007328:Insulin; D006003:Glycogen