title: Reconstruction of the perineum following anorectal cancer excision.
abstract: OBJECTIVE
  Most patients with anal cancer receive chemoradiotherapy as first-line treatment. Persistent/recurrent tumours will subsequently require an abdomino-perineal resection (APR). A proportion of the 20,000 new cases of rectal carcinoma diagnosed in the UK each year receive neo-adjuvant chemoradiation and then an APR. Healing of the irradiated perineal bed is compromised, resulting in high morbidity. Reconstruction of the perineam with well-vasularised tissue is thought to enhance healing. This study investigates a series of 18 patients who underwent APR for anorectal cancer with flap reconstruction of their perineum.
  
  
  METHODS
  A retrospective analysis of all anorectal cancers requiring an APR and flap reconstruction was performed. Casenotes were reviewed and documentation made of risk factors putting them at increased risk of wound complications. Length of stay, morbidity and outcome variables including primary flap healing were recorded.
  
  
  RESULTS
  Between November 2000 and October 2007, 18 cases were performed (M/F = 7:11), six for anal cancer and 12 for low rectal tumours. Pre-operative treatment was chemoradiotherapy in 14 (78%), radiotherapy alone in two (11%) and none in two (11%). Perineal reconstruction consisted of 14 vertical rectus abdominis myocutaneous flaps, three free latissimus dorsi flap and one transverse rectus abdominis myocutaneous flap. Mean hospital stay was 21.8 days (10-54 days). Complete healing was noted in 16 cases with the remaining two continuing to improve under current follow-up. There were no flap losses.
  
  
  CONCLUSIONS
  Despite most patients being treated with pre-operative radiotherapy, we have had significant success in obtaining primary healing of the perineal defect after APR.
authors.affiliation: Salisbury NHS Foundation Trust, Salisbury, Wiltshire, SP28BJ, UK.
authors.forename: Nicola
authors.initials: N
authors.lastname: Petrie
authors.forename: Graham
authors.initials: G
authors.lastname: Branagan
authors.forename: Caroline
authors.initials: C
authors.lastname: McGuiness
authors.forename: Shaun
authors.initials: S
authors.lastname: McGee
authors.forename: Clare
authors.initials: C
authors.lastname: Fuller
authors.forename: Helen
authors.initials: H
authors.lastname: Chave
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010502:Perineum / Q000601:surgery*; D011183:Postoperative Complications; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000628:therapy*; D012189:Retrospective Studies; D013524:Surgical Flaps; D014945:Wound Healing