title: Altered pharmacology in the Intensive Care Unit patient.
abstract: Critically ill patients, not infrequently present alterations of physiological parameters that determine the success/failure of therapeutic interventions as well as the final outcome. Sepsis and polytrauma are two of the most common and complex syndromes occurring in Intensive Care Unit (ICU) and affect drug absorption, disposition, metabolism and elimination. Pharmacological management of ICU patients requires consideration of the unique pharmacokinetics associated with these clinical conditions and the likely occurrence of drug interaction. Rational adjustment in drug choice and dosing contributes to the appropriateness of treatment of those patients.
authors.affiliation: Department of Critical Care Medicine and Surgery, University of Florence and Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. giovanni.zagli@unifi.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Zagli
authors.forename: Francesca
authors.initials: F
authors.lastname: Tarantini
authors.forename: Manuela
authors.initials: M
authors.lastname: Bonizzoli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Di Filippo
authors.forename: Adriano
authors.initials: A
authors.lastname: Peris
authors.forename: Angelo Raffaele
authors.initials: AR
authors.lastname: De Gaudio
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Geppetti
mesh_terms: D016638:Critical Illness / Q000401:mortality / Q000628:therapy*; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D007362:Intensive Care Units / Q000639:trends; D009104:Multiple Trauma / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D018805:Sepsis / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality; D016896:Treatment Outcome
chemical_list: D004364:Pharmaceutical Preparations