[Alcohol dehydrogenase and aldehyde dehydrogenase in malignant diseases--part I].
Chronic alcohol consumption is a risk factor for many cancers, e.g. upper digestive tract, liver, pancreas, colorectum and breast. The main role in carcinogenesis plays toxic and carcinogenic acetaldehyde. Formation and degradation of acetaldehyde in the body is modified by activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). They are polymorphic enzymes localized in different organs and catalyzing many others biochemical reactions.
Orywal
Karolina
K
Uniwersytet Medyczny w Białymstoku, Zakład Diagnostyki Biochemicznej. orywalk@amb.edu.pl
Jelski
Wojciech
W
Szmitkowski
Maciej
M
D000079:Acetaldehyde / Q000378:metabolism; D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000437:Alcoholism / Q000201:enzymology* / Q000453:epidemiology*; D000444:Aldehyde Dehydrogenase / Q000378:metabolism*; D015984:Causality; D015897:Comorbidity; D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000453:epidemiology*
D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde