Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones.
Triazinane diones, readily generated by a recently reported multicomponent reaction, can be easily alkylated with various alkyl halides, allowing a wide variety of complexity-generating secondary reactions. Because of the high variability of the initial multicomponent reactions and the multiple possibilities for participation of substituents in the secondary reactions, a highly diverse set of complex products was obtained in short and efficient reaction sequences.
Groenendaal
Bas
B
Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands.
Ruijter
Eelco
E
de Kanter
Frans J J
FJ
Lutz
Martin
M
Spek
Anthony L
AL
Orru
Romano V A
RV
D000478:Alkylation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D003500:Cyclization; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry*
D007659:Ketones; D014227:Triazines