title: Placental calcification in pseudoxanthoma elasticum.
abstract: BACKGROUND
  Pseudoxanthoma elasticum (PXE) is an inherited multisystem disorder of the elastic tissue and the objective of this case report is to correlate ultrasonographic and histological appearances of placental calcification in PXE.
  
  
  METHODS
  We report a case of a 37-year-old white woman with PXE, whose antenatal imaging showed a markedly echogenic placenta due to extensive calcification confirmed on postpartum placental histology.
  
  
  RESULTS
  There were no maternal or fetal complications in the antenatal period. A healthy baby of appropriate maturity and weight was delivered via Caesarean section and remained well at 6 months.
  
  
  CONCLUSIONS
  The majority of cases of PXE is caused by mutations in the ABCC6 gene. Serious complications in pregnancy can include gastrointestinal haemorrhage, congestive heart failure and cardiac arrhythmia but has not been shown to be associated with markedly increased fetal loss or adverse reproductive outcomes as reported in previous literature. Apart from the cosmetic deterioration of the abdominal skin, there were few serious complications and most have normal pregnancies. Obstetric prognosis is dependent on the vascular damage caused by the illness. There is no basis for advising women with PXE to avoid becoming pregnant, and most pregnancies in PXE are uncomplicated.
authors.affiliation: Department of Obsterics and Gynaecology, Singapore General Hospital, Singapore. aileen_tan2000@yahoo.com.sg
authors.forename: Wei Ching
authors.initials: WC
authors.lastname: Tan
authors.forename: Charles H
authors.initials: CH
authors.lastname: Rodeck
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000175:diagnosis / Q000209:etiology*; D002585:Cesarean Section; D005260:Female; D006801:Humans; D010922:Placenta Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011561:Pseudoxanthoma Elasticum / Q000150:complications* / Q000175:diagnosis; D012307:Risk Factors