Preventive effect of aminoguanidine compared to vitamin E and C on cisplatin-induced nephrotoxicity in rats.
In this study, the antioxidant effect of aminoguanidine on nephrotoxicity of a single dose of cisplatin is investigated and compared with the effects of well-known antioxidants vitamin C and E combination. Tubular damage and perivascular inflammation were observed in kidney samples of the cisplatin-administered groups. Aminoguanidine and vitamin C-E combination are found to be capable of preventing these effects of cisplatin. Liver tissues of all groups were intact. Cisplatin-induced oxidative stress was evidenced by significant decrease in glutathione and significant increase in malondialdehyde levels in kidney samples. Antioxidants with cisplatin decreased malondialdehyde levels. Antioxidants with cisplatin prevented the decrease in liver glutathione levels. The nephrotoxicity was confirmed biochemically by significant elevation of serum urea and creatinine levels. Both vitamin C-E combination and aminoguanidine prevented the increase in serum urea levels according to the cisplatin group.
Atasayar
S
S
Department of Toxicology, Hacettepe University, Sihhiye, Ankara, Turkey.
Gürer-Orhan
H
H
Orhan
H
H
Gürel
B
B
Girgin
G
G
Ozgüneş
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D002945:Cisplatin / Q000633:toxicity*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005978:Glutathione / Q000187:drug effects; D006146:Guanidines / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014508:Urea / Q000097:blood; D014810:Vitamin E / Q000627:therapeutic use
D000970:Antineoplastic Agents; D000975:Antioxidants; D004791:Enzyme Inhibitors; D006146:Guanidines; D014810:Vitamin E; D008315:Malondialdehyde; D014508:Urea; D005978:Glutathione; D001205:Ascorbic Acid; D002945:Cisplatin; C004479:pimagedine