The major histocompatibility complex and genetic control of antibody response to sheep red blood cells in chickens.
The genetic association of the B-F/B-L region of the chicken major histocompatibility complex (MHC) with the antibody response to sheep red blood cells (SRBC) was investigated using three inbred lines of White Leghorn chickens. Two out of the three inbred lines of chickens. J1 and N1, were found to be a low responder to SRBC. Planned matings between the three inbred lines of chickens showed that the genetic regulation of the magnitude of the antibody response to SRBC was associated with the MHC. The low antibody response to SRBC was inherited as a recessive trait linked to the B15 MHC phenotype of the M1 inbred line.
Loudovaris
T
T
Division of Animal Health, Animal Health Research Laboratory, CSIRO, Parkville, Victoria, Australia.
Brandon
M R
MR
Fahey
K J
KJ