Frequency-specific coupling in the cortico-cerebellar auditory system.
Induced oscillatory activity in the auditory cortex peaks at around 40 Hz in humans. Using regional cerebral blood flow and positron emission tomography we previously confirmed frequency-selective cortical responses to 40-Hz tones in auditory primary cortices and concomitant bilateral activation of the cerebellar hemispheres. In this study, using functional magnetic resonance imaging (fMRI) we estimated the influence of 40-Hz auditory stimulation on the coupling between auditory cortex and superior temporal sulcus (STS) and Crus II, using a dynamic causal model of the interactions between medial geniculate nuclei, auditory superior temporal gyrus (STG)/STS, and the cerebellar Crus II auditory region. Specifically, we tested the hypothesis that 40-Hz-selective responses in the cerebellar Crus II auditory region could be explained by frequency-specific enabling of interactions in the auditory cortico-cerebellar-thalamic loop. Our model comparison results suggest that input from auditory STG/STS to cerebellum is enhanced selectively at gamma-band frequencies around 40 Hz.
Pastor
M A
MA
Centre for Applied Medical Research, Department of the Neurosciences, University of Navarra School of Medicine, CUN, 31080 Pamplona, Spain. mapastor@unav.es
Vidaurre
C
C
Fernández-Seara
M A
MA
Villanueva
A
A
Friston
K J
KJ
D000161:Acoustic Stimulation; D000328:Adult; D000465:Algorithms; D001303:Auditory Cortex / Q000502:physiology*; D001306:Auditory Pathways / Q000502:physiology; D002531:Cerebellum / Q000502:physiology*; D003627:Data Interpretation, Statistical; D017352:Echo-Planar Imaging; D006309:Hearing / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008959:Models, Neurological; D013788:Thalamus / Q000502:physiology