title: Activated, type I collagen (CellerateRx) and its effectiveness in healing recalcitrant diabetic wounds: a case presentation.
abstract: OBJECTIVE
  To review the authors' experience with activated type I collagen in the treatment of recalcitrant wounds in the diabetic population resulting from minor trauma and/or venous stasis disease. With regard to activated collagen, CellerateRx's patented activated collagen fragments are a fraction of the size of the native collagen molecules and particles found in other products, delivering the benefits of collagen to the body immediately.
  
  
  METHODS
  A 2-case presentation wherein patients were treated with CellerateRx (activated, fragmented, and nonintact type I collagen) in a gel and powder form.
  
  
  METHODS
  Two middle-aged diabetic male patients with lower extremity wounds refractory to conservative wound care.
  
  
  RESULTS
  Complete resolution of recalcitrant wounds in 6 to 7 weeks.
  
  
  CONCLUSIONS
  Wound resolution was evident when using the authors' practice protocol, which includes the application of activated collagen. The inherent properties of type I collagen may contribute to a more rapid healing process.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Cleveland Clinic Florida, Weston, FL, USA.
authors.forename: Martin I
authors.initials: MI
authors.lastname: Newman
authors.forename: Larry G
authors.initials: LG
authors.lastname: Baratta
authors.forename: Kimberly
authors.initials: K
authors.lastname: Swartz
mesh_terms: D000368:Aged; D024042:Collagen Type I / Q000627:therapeutic use*; D048909:Diabetes Complications / Q000188:drug therapy*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011347:Procollagen / Q000627:therapeutic use*; D012008:Recurrence; D012883:Skin Ulcer / Q000188:drug therapy* / Q000209:etiology; D017211:Treatment Failure; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D024042:Collagen Type I; D011347:Procollagen