A case control study of statin and magnesium administration in patients after aneurysmal subarachnoid hemorrhage: incidence of delayed cerebral ischemia and mortality.
OBJECTIVE
To analyse the effect of the implementation of statin and magnesium treatment on delayed cerebral ischemia (DCI) and 14 day mortality in patients with subarachnoid hemorrhage (SAH).


METHODS
Retrospective, single-center, observational case control study. One hundred SAH patients received either simvastatin and magnesium, solely statin or no treatment.


RESULTS
Eighteen percent (n=5) of patients receiving statin and magnesium treatment developed a DCI whereas 24% (n=5) in the statin group and 16% (n=8) in the control group had DCI. Dead by day 14 was registered in 18% (n=5) of patients in the statin and magnesium group, in 10% (n=2) in the statin group and in 27% (n=14) in the control group. None of the results reached a statistical significance level of 0.05.


CONCLUSIONS
A trend towards a lower mortality within 14 days in patients receiving solely simvastatin and those receiving statin and magnesium as compared with the control group was found. A higher incidence for DCI was found in the statin group, whereas patients without statin and magnesium tended to have less often DCI. None of the results was statistically significant.
Kerz
Thomas
T
Department of Neurosurgery, Johannes Gutenberg-University Hospital Medical School, Mainz, Germany. kerz@uni-mainz.de
Victor
Anja
A
Beyer
Christian
C
Trapp
Inka
I
Heid
Florian
F
Reisch
Robert
R
D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002545:Brain Ischemia / Q000453:epidemiology / Q000209:etiology / Q000401:mortality; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008274:Magnesium / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D019821:Simvastatin / Q000009:adverse effects / Q000627:therapeutic use*; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000188:drug therapy*; D015996:Survival Rate; D016896:Treatment Outcome
D000924:Anticholesteremic Agents; D019821:Simvastatin; D008274:Magnesium