title: Small molecules targeting p53 to improve antitumor therapy.
abstract: Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.
authors.affiliation: Department of Experimental Oncology and Laboratories, Fondazione IRCCS, Istituto Nazionale Tumori, Via Venezian 1, Milan, Italy. giovanni.beretta@istitutotumori.mi.it
authors.forename: G L
authors.initials: GL
authors.lastname: Beretta
authors.forename: L
authors.initials: L
authors.lastname: Gatti
authors.forename: V
authors.initials: V
authors.lastname: Benedetti
authors.forename: P
authors.initials: P
authors.lastname: Perego
authors.forename: F
authors.initials: F
authors.lastname: Zunino
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D017209:Apoptosis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008954:Models, Biological; D008956:Models, Chemical; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D009687:Nuclear Proteins / Q000737:chemistry; D011485:Protein Binding; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D009687:Nuclear Proteins; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2