title: Liver transplantation using donors older than 80 years: a single-center experience.
abstract: OBJECTIVE
  The shortage of organs for orthotopic liver transplantation (OLT) has forced transplantation centers to expand the donor pool by using donors traditionally labeled as "extended criteria donors." One such example is OLT using a donor with advanced age.
  
  
  METHODS
  We retrospectively evaluated 10 patients who received a liver graft from cadaveric donors older than 80 years. We analyzed pretransplantation donor and recipient characteristics, as well as the evolution of the recipients.
  
  
  RESULTS
  All 10 donors were older than 80 years (median age, 83.5; range, 80-93). No steatosis (>30%) was accepted in the older donor group. Medium follow-up was 19.5 months. The most frequent cause for OLT was hepatitis C virus (HCV) cirrhosis (8/10 patients). We had 1 case of primary nonfunction, 1 patient died immediately after surgery because of extrahepatic complications (cardiac arrest), and 2 other patients had a severe HCV recurrence and died after 1 and 2 years from OLT, respectively. Five patients had HCV recurrence and biliary complications were present in 60% of the patients. No cases of acute or chronic rejection were described. Overall survival rates after 1 and 3 years were 80% and 40%, respectively.
  
  
  CONCLUSIONS
  Old donor age is not an absolute contraindication to OLT. Liver grafts from donors older than 80 years can be used knowing that there is a high risk of postoperative complications. Furthermore, the increased risk of developing severe HCV recurrence, related to older donor age, suggests that such livers should be used in HCV-negative recipients.
authors.affiliation: Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Petridis
authors.forename: S
authors.initials: S
authors.lastname: Gruttadauria
authors.forename: S
authors.initials: S
authors.lastname: Nadalin
authors.forename: J
authors.initials: J
authors.lastname: Viganò
authors.forename: F
authors.initials: F
authors.lastname: di Francesco
authors.forename: G
authors.initials: G
authors.lastname: Pietrosi
authors.forename: D
authors.initials: D
authors.lastname: Fili'
authors.forename: M
authors.initials: M
authors.lastname: Montalbano
authors.forename: A
authors.initials: A
authors.lastname: D'Antoni
authors.forename: R
authors.initials: R
authors.lastname: Volpes
authors.forename: A
authors.initials: A
authors.lastname: Arcadipane
authors.forename: G
authors.initials: G
authors.lastname: Vizzini
authors.forename: B
authors.initials: B
authors.lastname: Gridelli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000601:surgery* / Q000821:virology; D005260:Female; D006085:Graft Survival; D006509:Hepatitis B / Q000601:surgery; D006526:Hepatitis C / Q000601:surgery; D003699:Hepatitis D / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery* / Q000821:virology; D016031:Liver Transplantation / Q000401:mortality* / Q000706:statistics & numerical data*; D019520:Living Donors / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors