title: Early morphological changes and functional abnormalities in group 2A idiopathic juxtafoveolar retinal telangiectasis using spectral domain optical coherence tomography and microperimetry.
abstract: OBJECTIVE
  To report early morphological changes and functional abnormalities in group 2A idiopathic juxtafoveolar retinal telangiectasis (IJRT) using spectral domain optical coherence tomography (SD-OCT) and microperimetry.
  
  
  METHODS
  Six eyes (three patients; average age, 64 years) with group 2A IJRT were examined using SD-OCT and microperimetry.
  
  
  RESULTS
  On SD-OCT, breaks in the highly reflective line, considered the boundary between the photoreceptor inner and outer segments, at the temporal to the fovea and corresponding to the telangiectasis lesions were observed in all eyes. Highly reflective tissue was observed in the outer retinal layer in five eyes. In three eyes with a right-angle venule, the outer retinal layer was replaced by the highly reflective tissue and was contiguous to the inner retinal layer. Microperimetry showed the reduction in the retinal sensitivity thresholds at the temporal to the fovea in five eyes.
  
  
  CONCLUSIONS
  Early morphological alterations in group 2A IJRT in SD-OCT were observed. These finding might be visualisation of Müller cell abnormality on SD-OCT. At the same time, the disorder of photoreceptors occurs at the telangiectasis lesions from MP-1. Detailed observation of these abnormalities provides an understanding of the morphological and functional features of group 2A IJRT.
authors.affiliation: Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Maruko
authors.forename: T
authors.initials: T
authors.lastname: Iida
authors.forename: T
authors.initials: T
authors.lastname: Sekiryu
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
mesh_terms: D000368:Aged; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods; D005584:Fovea Centralis / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology*; D012164:Retinal Diseases / Q000473:pathology*; D013684:Telangiectasis / Q000473:pathology* / Q000503:physiopathology; D041623:Tomography, Optical Coherence / Q000379:methods*; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests / Q000379:methods