title: Corneal biomechanics, thickness and optic disc morphology in children with optic disc tilt.
abstract: OBJECTIVE
  To determine the associations between corneal biomechanical parameters as measured by the Reichert Ocular Response Analyser (ORA) and disc morphology and retinal nerve fibre layer thickness (RNFL) measured by the Heidelberg Retinal Tomograph (HRT) II in Singaporean children.
  
  
  METHODS
  This is a cross-sectional study conducted on a subset of children enrolled in the Singapore Cohort Study of the Risk Factors of Myopia (SCORM). Corneal hysteresis (CH), corneal resistance factor (CRF) and central corneal thickness (CCT) were measured with the ORA. Optic disc morphology and RNFL thickness were assessed by the HRT II. Cycloplegic refraction and ultrasound A-scans were also performed, and disc tilt was assayed from stereo photographs.
  
  
  RESULTS
  102 subjects (mean age 12.01 (SD 0.57) years; range 11-14 years) were included in the study. The mean CH was 12.00 (1.40) mm Hg, the mean CRF was 11.99 (1.65) mm Hg, and the mean CCT was 581.12 (33.53) mum. Eyes with tilted discs had significantly longer axial lengths and more myopic refraction than eyes without tilted discs. There were no significant correlations between CH, CRF or CCT and the HRT II parameters, after the application of the Bonferroni correction. When stratified for disc tilt, however, the global disc area was significantly correlated with CCT (r = -0.49, p = 0.001).
  
  
  CONCLUSIONS
  Corneal biomechanical properties as measured with the ORA do not vary with optic disc parameters or RNFL. Central corneal thickness is correlated with disc area in Singaporean schoolchildren with tilted discs. This relationship may influence glaucoma risk in myopic subjects.
authors.affiliation: Singapore Eye Research Institute, Singapore.
authors.forename: L
authors.initials: L
authors.lastname: Lim
authors.forename: G
authors.initials: G
authors.lastname: Gazzard
authors.forename: Y-H
authors.initials: YH
authors.lastname: Chan
authors.forename: A
authors.initials: A
authors.lastname: Fong
authors.forename: A
authors.initials: A
authors.lastname: Kotecha
authors.forename: E-L
authors.initials: EL
authors.lastname: Sim
authors.forename: D
authors.initials: D
authors.lastname: Tan
authors.forename: L
authors.initials: L
authors.lastname: Tong
authors.forename: S-M
authors.initials: SM
authors.lastname: Saw
mesh_terms: D000293:Adolescent; D001696:Biomechanical Phenomena; D002648:Child; D003315:Cornea / Q000002:abnormalities / Q000473:pathology* / Q000503:physiopathology*; D003316:Corneal Diseases / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation; D005260:Female; D005901:Glaucoma / Q000517:prevention & control; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D009216:Myopia / Q000503:physiopathology; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000002:abnormalities / Q000473:pathology* / Q000502:physiology; D012030:Refractive Errors / Q000503:physiopathology*; D012846:Singapore; D014212:Tretinoin
chemical_list: D014212:Tretinoin