Role of complexes formation between drugs and penetration enhancers in transdermal delivery.
The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects.
Drakulić
Branko J
BJ
Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, University of Belgrade, Belgrade, Serbia.
Juranić
Ivan O
IO
Erić
Slavica
S
Zloh
Mire
M
D000279:Administration, Cutaneous; D002626:Chemistry, Pharmaceutical; D003198:Computer Simulation; D004008:Diclofenac / Q000008:administration & dosage / Q000737:chemistry; D004339:Drug Compounding; D004958:Estradiol / Q000008:administration & dosage / Q000737:chemistry; D005472:Fluorouracil / Q000008:administration & dosage / Q000737:chemistry; D006854:Hydrocortisone / Q000008:administration & dosage / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D014677:Pharmaceutical Vehicles; D012869:Skin Absorption; D013729:Terpenes / Q000737:chemistry*
D004364:Pharmaceutical Preparations; D014677:Pharmaceutical Vehicles; D013729:Terpenes; D004008:Diclofenac; D004958:Estradiol; D005472:Fluorouracil; D006854:Hydrocortisone