Mechanistically inspired catalysts for enantioselective desymmetrizations by olefin metathesis.
In asymmetric olefin metathesis reactions, the addition of halide additives is often required to augment enantioselectivities, despite the fact that the additives result in catalysts with diminished reactivities. The preparation of new chiral Ru-based catalysts was accomplished by exploiting previously reported mechanistic studies. The catalysts possess a high level of reactivity and successfully induce high levels of asymmetry in desymmetrization reactions without the use of halide additives.
Fournier
Pierre-André
PA
Department of Chemistry, Université de Montréal, Station Downtown, Montréal, PQ, Canada.
Savoie
Jolaine
J
Stenne
Brice
B
Bédard
Marion
M
Grandbois
Alain
A
Collins
Shawn K
SK
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D013237:Stereoisomerism
D000475:Alkenes