The HTLV-1 Tax interactome.
The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.
Boxus
Mathieu
M
University Academia Wallonie-Europe, Molecular and Cellular Biology at FUSAGx, Gembloux, Belgium. boxus.m@fsagx.ac.be
Twizere
Jean-Claude
JC
Legros
Sébastien
S
Dewulf
Jean-François
JF
Kettmann
Richard
R
Willems
Luc
L
D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D016356:Gene Products, tax / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015490:HTLV-I Infections / Q000378:metabolism* / Q000503:physiopathology / Q000821:virology; D054884:Host-Pathogen Interactions; D015368:Human T-lymphotropic virus 1 / Q000737:chemistry / Q000201:enzymology* / Q000235:genetics; D006801:Humans; D028861:Nuclear Pore Complex Proteins / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation
D018797:Cell Cycle Proteins; D016356:Gene Products, tax; D028861:Nuclear Pore Complex Proteins; D014157:Transcription Factors