title: Sodium butyrate enhances the cytotoxic effect of antineoplastic drugs in human lymphoblastic T-cells.
abstract: Sodium butyrate (NaB), a potent histone deacetylase inhibitor, induces cell cycle arrest and apoptosis in malignant cells. We investigated the effects on cellular proliferation in vitro when combining NaB with antineoplastic drugs commonly used to treat leukemias. Our results demonstrate that NaB increases the cytotoxic effects of cytarabine and etoposide, but not of bleomycin, doxorubicin, vincristine or methotrexate. These data suggest that NaB is a promising adjuvant therapeutic agent for the treatment of lymphoblastic leukemias, and provides a basis for further studies in this field.
authors.affiliation: Cancer Research Laboratory, Academic Hospital Research Center, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil.
authors.forename: M P
authors.initials: MP
authors.lastname: dos Santos
authors.forename: G
authors.initials: G
authors.lastname: Schwartsmann
authors.forename: R
authors.initials: R
authors.lastname: Roesler
authors.forename: A L
authors.initials: AL
authors.lastname: Brunetto
authors.forename: A L
authors.initials: AL
authors.lastname: Abujamra
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001761:Bleomycin; D002087:Butyrates / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D003561:Cytarabine; D004317:Doxorubicin; D004357:Drug Synergism; D005047:Etoposide; D006801:Humans; D019169:Jurkat Cells; D015458:Leukemia, T-Cell / Q000188:drug therapy* / Q000473:pathology; D008727:Methotrexate; D013601:T-Lymphocytes / Q000187:drug effects* / Q000473:pathology; D014750:Vincristine
chemical_list: D000970:Antineoplastic Agents; D002087:Butyrates; D003561:Cytarabine; D001761:Bleomycin; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D008727:Methotrexate