Malaria vaccines: immunity, models and monoclonal antibodies.
Although experts in the field have agreed on the malaria vaccine technology roadmap that should be followed (http://www.malariavaccineroadmap.net/), the path towards an effective malaria vaccine remains littered with intellectual and practical pot-holes. The animal models that are currently available are problematic, and current understanding of the exact mechanisms and targets of protective immune responses is incomplete. However, recent technological advances might help overcome some of these hurdles.
Hviid
Lars
L
Centre for Medical Parasitology at the Department for International Health, Immunology, and Microbiology (ISIM), University of Copenhagen, 1014 Copenhagen K, Denmark. lhcmp@rh.dk
Barfod
Lea
L
D000818:Animals; D000911:Antibodies, Monoclonal; D004195:Disease Models, Animal; D000882:Haplorhini; D006801:Humans; D017780:Malaria Vaccines / Q000276:immunology*; D016778:Malaria, Falciparum / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000276:immunology; D051381:Rats
D000911:Antibodies, Monoclonal; D017780:Malaria Vaccines