FCER1A   gene proximal promoter polymorphisms in Caucasians and   East Asians.
Two FCER1A gene proximal promoter polymorphisms, -344C > T and -95T > C, both associated with total serum IgE and/or allergic disorders in Caucasians and East Asians, were shown to influence the gene expression in additive manner. In face of the rarity of other proximal promoter variants in Caucasians or their lack in East Asians, future investigations of the FCER1A locus in these ethnic groups should probably focus on three common haplotypes of the common -344C > T and -95T > C polymorphisms.
Potaczek
D P
DP
Department of Medicine, Jagiellonian University School of Medicine, Cracow, Poland.
Sanak
M
M
Nishiyama
C
C
Okumura
K
K
Ogawa
H
H
Szczeklik
A
A
D044466:Asian People / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D017455:Receptors, IgE / Q000235:genetics*; D044465:White People / Q000235:genetics*
C475664:FCER1A protein, human; D017455:Receptors, IgE