Effect of an orally active Th2 cytokine inhibitor, suplatast on "atopic cough" tosilate.
BACKGROUND
"Atopic cough" is a new clinical entity that presents with isolated chronic bronchodilator-resistant cough accepted in the Japanese Respiratory Society Guidelines for Management of Cough. The essential features are eosinophilic tracheobronchitis, increased cough reflex sensitivity and an atopic constitution. It has been suggested that activated helper T lymphocytes and the cytokines which are produced by these cells are involved in the pathogenesis, but the relationship between helper T cell-derived cytokines and the airway cough reflex sensitivity remains unknown.


METHODS
The effect of an orally active Th2 cytokine inhibitor, suplatast tosilate (CAS 94055-76-2, IPD; 300 mg/day), on the cough response to inhaled capsaicin (CAS 404-86-4) was examined in ten patients with atopic cough. The capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough reflex sensitivity. The serum total immunoglobulin E (IgE) level and the peripheral blood eosinophil count were also determined after treatment with suplatast tosilate.


RESULTS
The cough threshold measured after four weeks of treatment with suplatast tosilate was significantly increased compared to the value obtained with placebo, along with a decrease of the serum IgE level and peripheral eosinophil count.


CONCLUSIONS
Th2 cytokines may increase the airway cough reflex sensitivity in patients with atopic cough. Oral administration of suplatast tosilate may be a novel therapy for atopic cough.
Ishiura
Yoshihisa
Y
Department of Respiratory Medicine, Toyama City Hospital, Toyama, Japan. ishiura-@p2322.nsk.ne.jp
Fujimura
Masaki
M
Yamamoto
Hiroki
H
Nobata
Kouichi
K
Ishiguro
Takashi
T
Ogawa
Haruhiko
H
Myou
Shigeharu
S
D000328:Adult; D000368:Aged; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D001190:Arylsulfonates / Q000627:therapeutic use*; D001980:Bronchi / Q000187:drug effects; D001993:Bronchodilator Agents / Q000494:pharmacology; D002211:Capsaicin; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy*; D016207:Cytokines / Q000096:biosynthesis*; D004351:Drug Resistance; D004804:Eosinophils; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D012018:Reflex / Q000187:drug effects; D012129:Respiratory Function Tests; D013452:Sulfonium Compounds / Q000627:therapeutic use*; D018418:Th2 Cells / Q000187:drug effects* / Q000378:metabolism*; D014797:Vital Capacity / Q000187:drug effects
D018926:Anti-Allergic Agents; D001190:Arylsulfonates; D001993:Bronchodilator Agents; D016207:Cytokines; D007074:Immunoglobulin G; D013452:Sulfonium Compounds; C073028:suplatast tosilate; D002211:Capsaicin