title: MS07116 sodium selenosulfate synthesis and demonstration of its in vitro cytotoxic activity against HepG2, Caco2, and three kinds of leukemia cells.
abstract: The biological profile of sodium selenosulfate, Na(2)SeSO(3), is still largely unknown. The present study found that sodium sulfite reacted with elemental selenium at nanoparticle size already at 37 degrees C to yield sodium selenosulfate. Additionally, selenosulfate was obtained by mixing sodium selenite, glutathione, and sodium sulfite at room temperature. In vitro, sodium selenosulfate killed HepG2 or Caco2 cells, in a dose-dependent fashion, and 12.5 microM fully suppressed their proliferation. In addition, sodium selenosulfate showed a consistent cytotoxic effect when added to three kinds of leukemia cell lines (HL60, T lymph adenoma, and Daudi).
authors.affiliation: School of Chemistry and Material Science, University of Science and Technology of China, Anhui, People's Republic of China. zjszyzzc@mail.hf.ah.cn
authors.forename: Jinsong
authors.initials: J
authors.lastname: Zhang
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Lu
authors.forename: Xufang
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor / Q000187:drug effects*; D003603:Cytotoxins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D053938:DNA Fragmentation; D006801:Humans; D007938:Leukemia; D015394:Molecular Structure; D010316:Particle Size; D012643:Selenium / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D018036:Selenium Compounds / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D013431:Sulfates / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: D003603:Cytotoxins; D018036:Selenium Compounds; D013431:Sulfates; D012643:Selenium; C519925:sodium selenosulfate