[Beyond dyssynchrony: what are the factors determining the response to cardiac resynchronization therapy?].
Although cardiac resynchronization therapy is currently used for treatment of refractory heart failure in patients with low ejection fraction and cardiac dyssynchrony, there is a substantial number of non-responders. This indicates that, in addition to cardiac dyssynchrony, there are other factors affecting response to cardiac resynchronization therapy. Pre-implant identification of these factors appears of crucial importance in order to finalize the resynchronization treatment to those patients who have the highest probability of a positive response. In this review the main non-dyssynchrony determinants of response to cardiac resynchronization therapy are presented and discussed.
Mele
Donato
D
UO di Cardiologia, Azienda Ospedaliera Universitaria, Ferrara. donatomele@libero.it
Toselli
Tiziano
T
Dal Monte
Alessandro
A
Guardigli
Gabriele
G
Ceconi
Claudio
C
Ferrari
Roberto
R
D000368:Aged; D003663:Decision Trees; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial