[Linkage analysis of one family with autosomal dominant high myopia].
OBJECTIVE
To map the high myopia gene in a Chinese family with autosomal dominant high myopia.


METHODS
A family with autosomal dominant high myopia in three generations was collected. Eighteen short-tandem-repeat markers on previously reported loci linked to high myopia were chosen for genotyping and two-point linkage analysis was carried out.


RESULTS
The spherical equivalent of affected individuals ranges from -6.00D to -20.00D and the genetic pattern is autosomal dominant. The LOD score was less than -1 in all 18 microsatellite markers, indicating that there was no linkage between these markers and the high myopia related genes in this family.


CONCLUSIONS
A novel myopia locus for high-grade myopia may exist in the kindred. Genome-wide scan will be needed to determine this novel locus.
Chang
Jin-xia
JX
Department of Immunology, West China Medical Center, Sichuan University, Chengdu, Sichuan, 610041 People's Republic of China.
Zhang
Ding-ding
DD
Lin
Yin
Y
Liu
Bing
B
Lu
Fang
F
Tang
Xin
X
Yang
Yang
Y
Chen
Bin
B
Zhang
Chong-jie
CJ
Yang
Zheng-lin
ZL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009216:Myopia / Q000235:genetics*; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D012029:Refraction, Ocular / Q000502:physiology; D055815:Young Adult