The contribution of genes to osteoarthritis.
Osteoarthritis (OA) is the most prevalent form of arthritis in the elderly. A large body of evidence, including familial aggregation and classic twin studies, indicates that primary OA has a strong hereditary component that is likely polygenic in nature. Furthermore, traits related to OA, such as longitudinal changes in cartilage volume and progression of radiographic features, are also under genetic control. In recent years, several linkage analysis and candidate gene studies have been performed and have unveiled some of the specific genes involved in disease risk, such as FRZB and GDF5. The authors discuss the impact that future genome-wide association scans can have on our understanding of the pathogenesis of OA and on identifying individuals at high risk for developing severe OA.
Valdes
Ana M
AM
Twin Research & Genetic Epidemiology Unit, St. Thomas' Hospital Campus, Kings College London School of Medicine, London SE1 7EH, UK. ana.valdes@kcl.ac.uk
Spector
Timothy D
TD
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000235:genetics* / Q000503:physiopathology; D015207:Osteoarthritis, Hip / Q000235:genetics / Q000503:physiopathology; D020370:Osteoarthritis, Knee / Q000235:genetics / Q000503:physiopathology; D010375:Pedigree; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012737:Sex Factors
D019485:Bone Morphogenetic Proteins; D016326:Extracellular Matrix Proteins