Chemically-modified HA for therapy and regenerative medicine.
Hyaluronan (HA) is a very useful polymer, but its properties sometimes need to be altered or enhanced by chemical modification for biomedical applications. A wide variety of HA derivatives are currently used for eye surgery, joint viscoelastic supplementation, and anti-adhesion films. The future promises to deliver new classes of HA-based reagents as well as new polymers that can be used in situ with living cells or within the body.
Prestwich
Glenn D
GD
Department of Medicinal Chemistry and Center for Therapeutic Biomaterials, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108, USA. gprestwich@pharm.utah.edu
Kuo
Jing-Wen
JW
D002234:Carbodiimides / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D004952:Esters; D006820:Hyaluronic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use; D044968:Regenerative Medicine / Q000379:methods*
D002234:Carbodiimides; D003432:Cross-Linking Reagents; D004952:Esters; D011108:Polymers; D006820:Hyaluronic Acid