Thymus and Myasthenia Gravis: what can we learn from DNA microarrays?
This review is dedicated to John Newsom-Davis, who was an exceptional colleague and friend, always exchanging ideas with respect and consideration. We shall not forget his involvement and passion in search for the truth on the role of thymectomy in the management of Myasthenia Gravis (MG). In this short review, we shall summarize what we learnt from DNA microarrays applied to MG thymus. We shall focus on three main comparisons of the thymic transcriptomes: 1) highly hyperplastic MG patients versus non-MG adults; 2) corticosteroid-treated versus untreated seropositive MG patients; and 3) seronegative versus seropositive MG patients.
Cizeron-Clairac
Géraldine
G
CNRS UMR 8162, Université Paris-Sud, Hôpital Marie Lannelongue, 92350 Le Plessis-Robinson and Université Paris-Sud, 91405 Orsay, France.
Le Panse
Rozen
R
Frenkian-Cuvelier
Mélinée
M
Meraouna
Amel
A
Truffault
Frédérique
F
Bismuth
Jacky
J
Mussot
Sacha
S
Kerlero de Rosbo
Nicole
N
Berrih-Aknin
Sonia
S
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics / Q000378:metabolism; D007372:Interferons / Q000494:pharmacology; D008297:Male; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism; D009157:Myasthenia Gravis / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D013949:Thymus Extracts / Q000235:genetics / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*
D007136:Immunoglobulins; D009124:Muscle Proteins; D013949:Thymus Extracts; D007372:Interferons