GSTM1 polymorphism along with PM10 exposure contributes to the risk of preterm delivery.
We investigated the association between the risk of preterm delivery and each metabolic gene of glutathione S-transferases micro 1 (GSTM1), theta 1 (GSTT1) and cytochrome P450IA1 (CYP1A1) along with exposure to particulate matter<10 microm (PM10). This study was assumed to identify gene-environment interaction that increases the risk of preterm delivery. A case-control study was carried out on 117 women with preterm deliveries and 118 women with term deliveries in Seoul, Korea. Logistic regression analyses were performed to explore the impact of each gene, PM10 exposure and their interaction on the risk of preterm birth. The risk of preterm birth was associated with the GSTM1 null genotype only. Exposure to high levels of PM10 (>or=75th percentile) during the third trimester of pregnancy was associated with an increased risk of preterm birth when compared to low-level exposure to PM10 (<75th percentile). We found that exposure to high levels of PM10 during the third trimester in the presence of the GSTM1 null genotype is significantly associated with the risk of preterm delivery. This finding is biologically plausible and provides evidence for a gene-environment interaction that increases the risk of preterm birth.
Suh
Young-Ju
YJ
Center for Genome Research, Samsung Biomedical Research Institute, Seoul, Republic of Korea.
Ha
Eun-Hee
EH
Park
Hyesook
H
Kim
Young-Ju
YJ
Kim
Ho
H
Hong
Yun-Chul
YC
D000328:Adult; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics; D004781:Environmental Exposure; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007723:Korea / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D010316:Particle Size; D052638:Particulate Matter / Q000633:toxicity*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011264:Pregnancy Trimesters; D047928:Premature Birth / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors
D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase; D052638:Particulate Matter; C413545:glutathione S-transferase T1