title: Hepatic metastases: in vivo assessment of perfusion parameters at dynamic contrast-enhanced MR imaging with dual-input two-compartment tracer kinetics model.
abstract: This study was institutional review board approved, with waived patient consent for retrospective analysis of the data. The hepatic perfusion at dynamic contrast material-enhanced magnetic resonance (MR) imaging was commonly described and assessed by using a dual-input one-compartment tracer kinetics model. Although the tracer kinetics in normal liver parenchyma can be described by using a single compartment, functional changes in the tumor microenvironment can result in distinctly different tracer behavior that entails a second tissue compartment. A dual-input two-compartment model is proposed to describe the tracer behavior in hepatic metastases. The authors applied this model to the dynamic MR imaging data obtained in three patients. Perfusion parameter maps and region-of-interest analysis revealed that tracer behavior in hepatic metastases-in contrast to that in surrounding normal liver tissue, which effectively involves one compartment-can be described by using two compartments.
authors.affiliation: School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore.
authors.forename: Tong San
authors.initials: TS
authors.lastname: Koh
authors.forename: Choon Hua
authors.initials: CH
authors.lastname: Thng
authors.forename: Puor Sherng
authors.initials: PS
authors.lastname: Lee
authors.forename: Septian
authors.initials: S
authors.lastname: Hartono
authors.forename: Helmut
authors.initials: H
authors.lastname: Rumpel
authors.forename: Boon Cher
authors.initials: BC
authors.lastname: Goh
authors.forename: Sotirios
authors.initials: S
authors.lastname: Bisdas
mesh_terms: D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply* / Q000556:secondary*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D008962:Models, Theoretical; D012189:Retrospective Studies