Pharmacokinetics and pharmacodynamics in the newborn.
Pharmacokinetics and pharmacodynamics in the newborn are multifaceted: maturation processes of the systems committed to absorption, distribution, metabolism, and excretion partially overlap, making the newborn an extremely dynamic system, especially if compared with adults. In this short note, some of the relevant variables able to regulate these processes are reviewed according to published literature data.
Eberini
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I
Dipartimento di Scienze Farmacologiche, Università di Milano, via Giuseppe Balzaretti 9, Milano 20133, Italy. ivano.eberini@unimi.it
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D007234:Infant, Premature / Q000378:metabolism; D007408:Intestinal Absorption; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D014018:Tissue Distribution
D004364:Pharmaceutical Preparations