Potential clinical applications of quantum dots.
The use of luminescent colloidal quantum dots in biological investigations has increased dramatically over the past several years due to their unique size-dependent optical properties and recent advances in biofunctionalization. In this review, we describe the methods for generating high-quality nanocrystals and report on current and potential uses of these versatile materials. Numerous examples are provided in several key areas including cell labeling, biosensing, in vivo imaging, bimodal magnetic-luminescent imaging, and diagnostics. We also explore toxicity issues surrounding these materials and speculate about the future uses of quantum dots in a clinical setting.
Medintz
Igor L
IL
Center for Bio/Molecular Science and Engineering, Code 6900, US Naval Research Laboratory,Washington, DC, USA. imedintz@cbmse.nrl.navy.mil
Mattoussi
Hedi
H
Clapp
Aaron R
AR
D015374:Biosensing Techniques / Q000379:methods* / Q000639:trends; D031541:Fluorescence Resonance Energy Transfer / Q000379:methods* / Q000639:trends; D007089:Image Enhancement / Q000379:methods*; D007118:Immunoassay / Q000379:methods* / Q000639:trends; D008856:Microscopy, Fluorescence / Q000379:methods* / Q000639:trends; D045663:Quantum Dots