Epigenetics? Mediator does that too!
Adding to the concept that Mediator acts as an "integrative hub,"Ding et al. (2008) report in this issue of Molecular Cell that, by facilitating the recruitment of the G9a methyl transferase, Mediator can also promote epigenetic silencing of selected genes.
Malik
Sohail
S
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. maliks@rockefeller.edu
Roeder
Robert G
RG
D044127:Epigenesis, Genetic; D006367:HeLa Cells; D006649:Histocompatibility Antigens / Q000378:metabolism; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism; D006801:Humans; D056892:Mediator Complex; D038901:X-Linked Intellectual Disability / Q000235:genetics; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D011988:Receptors, Thyroid Hormone / Q000378:metabolism*; D012097:Repressor Proteins / Q000737:chemistry / Q000378:metabolism; D037941:Silencer Elements, Transcriptional / Q000235:genetics; D000099229:RE1-Silencing Transcription Factor
D006649:Histocompatibility Antigens; D011495:Histone-Lysine N-Methyltransferase; D056892:Mediator Complex; D011988:Receptors, Thyroid Hormone; D012097:Repressor Proteins; D000099229:RE1-Silencing Transcription Factor; C460107:MED12 protein, human; C445405:EHMT2 protein, human