title: Eradication of Barrett esophagus with early neoplasia by radiofrequency ablation, with or without endoscopic resection.
abstract: BACKGROUND
  Radiofrequency ablation is safe and effective for complete eradication of nondysplastic Barrett esophagus (BE). The aim was to report the combined results of two published and two ongoing studies on radiofrequency ablation of BE with early neoplasia, as presented at SSAT presidential plenary session DDW 2008.
  
  
  METHODS
  Enrolled patients had BE < or = 12 cm with early neoplasia. Visible lesions were endoscopically resected. A balloon-based catheter was used for circumferential ablation and an endoscope-based catheter for focal ablation. Ablation was repeated every 2 months until the entire Barrett epithelium was endoscopically and histologically eradicated.
  
  
  RESULTS
  Forty-four patients were included (35 men, median age 68 years, median BE 7 cm). Thirty-one patients first underwent endoscopic resection [early cancer (n = 16), high-grade dysplasia (n = 12), low-grade dysplasia (n = 3)]. Worst histology remaining after resection was high-grade (n = 32), low-grade (n = 10), or no (n = 2) dysplasia. After ablation, complete histological eradication of all dysplasia and intestinal metaplasia was achieved in 43 patients (98%). Complications following ablation were mucosal laceration at resection site (n = 3) and transient dysphagia (n = 4). After 21 months of follow-up (interquartile range 10-27), no dysplasia had recurred.
  
  
  CONCLUSIONS
  Radiofrequency ablation, with or without prior endoscopic resection for visible abnormalities, is effective and safe in eradicating BE and associated neoplasia.
authors.affiliation: Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
authors.forename: Roos E
authors.initials: RE
authors.lastname: Pouw
authors.forename: Joep J
authors.initials: JJ
authors.lastname: Gondrie
authors.forename: Carine M
authors.initials: CM
authors.lastname: Sondermeijer
authors.forename: Fiebo J
authors.initials: FJ
authors.lastname: ten Kate
authors.forename: Thomas M
authors.initials: TM
authors.lastname: van Gulik
authors.forename: Kausilia K
authors.initials: KK
authors.lastname: Krishnadath
authors.forename: Paul
authors.initials: P
authors.lastname: Fockens
authors.forename: Bas L
authors.initials: BL
authors.lastname: Weusten
authors.forename: Jacques J
authors.initials: JJ
authors.lastname: Bergman
mesh_terms: D000368:Aged; D001471:Barrett Esophagus / Q000150:complications / Q000473:pathology / Q000628:therapy*; D017115:Catheter Ablation; D004938:Esophageal Neoplasms / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged