title: Negative effect of leptin on bone mass in type 1 diabetes.
abstract: Studies investigating the effect of leptin on bone mass were inconsistent and some related it to the effect of insulin. We intend in this cross-sectional study to investigate the effect of leptin on bone mass in type 1 diabetic patients. We recruited 42 patients with type 1 diabetes for which we determined weight, height, HbA1c, microalbuminuria, serum leptin, bone mineral content (BMC) and density (BMD), and body composition. The patients had an average age of 20.1 +/- 0.6 years, an average body mass index (BMI) of 23.6 +/- 0.5 kg/cm(2) and an average duration of diabetes of 9.1 +/- 1.0 years. The Z-score was not correlated with HbA1c or duration of the disease, and the average Z-score was not different in patients with microalbuminuria as compared to patients with no reported microalbuminuria. On the other hand, Z-score and BMC correlated negatively with leptin (r = -0.31; p = 0.04 and -0.60, p < 0.01, respectively). These correlations persisted after adjustment for fat mass. We conclude that not metabolic control of diabetes, but serum leptin has a negative effect on bone density in young patients with type 1 diabetes. This negative effect of leptin on bone density maybe, in part, due to deficiency of endogenous insulin secretion in these patients.
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon.
authors.forename: Hania S
authors.initials: HS
authors.lastname: Kassem
authors.forename: Asma
authors.initials: A
authors.lastname: Arabi
authors.forename: Mira S
authors.initials: MS
authors.lastname: Zantout
authors.forename: Sami T
authors.initials: ST
authors.lastname: Azar
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D017668:Age of Onset; D015992:Body Mass Index; D015519:Bone Density / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D020738:Leptin / Q000097:blood / Q000502:physiology*; D008297:Male; D055815:Young Adult
chemical_list: D006442:Glycated Hemoglobin; D007328:Insulin; D020738:Leptin