IMVAMUNE, an attenuated modified vaccinia Ankara virus vaccine for smallpox infection.
Bavarian Nordic is developing IMVAMUNE, which is based on a live attenuated modified vaccinia Ankara virus, for the potential prevention of smallpox infection, particularly in those patients contraindicated to traditional smallpox vaccines, such as the immunocompromised and those with eczema or dermatitis. In phase I and II clinical trials, IMVAMUNE was highly immunogenic and safe with no unexpected side effects or serious adverse effects reported in either healthy volunteers, those immunocompromised by HIV infection or in volunteers with atopic dermatitis. Additional phase II trials were ongoing in these groups at the time of publication and phase III trials were planned for 2009.
Jones
Taff
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MedImmune Inc, 297 N Bernardo Ave, Mountain View, CA 94043, USA. JonesD@MedImmune.com
D000818:Animals; D002986:Clinical Trials as Topic; D003876:Dermatitis, Atopic / Q000276:immunology; D015658:HIV Infections / Q000276:immunology; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D006801:Humans; D012899:Smallpox / Q000266:history / Q000276:immunology / Q000517:prevention & control*; D012900:Smallpox Vaccine / Q000266:history / Q000276:immunology* / Q000627:therapeutic use; D014613:Vaccines, Attenuated / Q000276:immunology / Q000627:therapeutic use*; D014616:Vaccinia virus / Q000235:genetics / Q000276:immunology
D012900:Smallpox Vaccine; D014613:Vaccines, Attenuated