title: The difference of contrast effects of myelography in normal dogs: comparison of iohexol (180 mgI/ml), iohexol (240 mgI/ml) and iotrolan (240 mgI/ml).
abstract: The contrast effects of three different contrast media preparations (iohexol 180 mgI/ml, iohexol 240 mgI/ml and iotrolan 240 mgI/ml) in conventional and CT myelography were compared. Three beagle dogs were used and the study employed a cross-over method (total of 9) for each contrast media. The result of CT myelography showed that the contrast effect of iohexol (180 mgI/ml), which had low viscosity, was highest in cranial sites, and the contrast effect of high-viscosity iotrolan (240 mgI/ml) was highest in caudal sites 5 min after injection of the contrast media preparations. This shows that the diffusion of contrast media preparations in the subarachnoid space is influenced by viscosity. The results of conventional myelography also showed that the diffusion of contrast media preparations is influenced by viscosity. Therefore, it is important to identify the location of spinal lesions in veterinary practice, and low viscosity contrast medium preparation with wide spread contrast effects is considered suitable for myelography.
authors.affiliation: Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
authors.forename: Junichiro
authors.initials: J
authors.lastname: Shimizu
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Yamada
authors.forename: Miori
authors.initials: M
authors.lastname: Kishimoto
authors.forename: Toshiroh
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Yoh-Ichi
authors.initials: Y
authors.lastname: Miyake
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage* / Q000737:chemistry; D018592:Cross-Over Studies; D004285:Dogs / Q000033:anatomy & histology* / Q000378:metabolism; D007472:Iohexol / Q000737:chemistry / Q000493:pharmacokinetics; D008297:Male; D009192:Myelography / Q000379:methods / Q000662:veterinary*; D013116:Spinal Cord / Q000000981:diagnostic imaging; D014283:Triiodobenzoic Acids / Q000737:chemistry / Q000493:pharmacokinetics; D014783:Viscosity
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C033300:iotrolan; D007472:Iohexol