Hemostatic safety of the bolus intravenous injection of a novel medium-chain triglyceride:fish oil emulsion.
The bolus intravenous injection of a novel 8:2 medium-chain triglyceride:fish oil emulsion was recently found to increase within 60 min and for the subsequent 24-48 h the long-chain polyunsaturated omega3 fatty acid content of both leucocyte and platelet phospholipids in 12 normal subjects. The aim of the present report is to document the hemostatic safety of such a procedure in the same 12 subjects. No adverse effect was found when comparing the results obtained after administration of either the fish oil-containing emulsion or a control 5:5 medium-chain triglyceride:soybean triglyceride emulsion, whether in terms of the occlusion time in either an ADP or epinephrine test or in terms of the [CD]42b, [CD]62p, fibrinogen and PAC-1 response to ADP, collagen or thrombin receptor analog peptide 6 in platelets examined by fluorescence activated cell sorting. In conclusion, this novel procedure for the rapid enrichment of cell phospholipid in long-chain polyunsaturated omega3 fatty acids presents the required safety in a hemostatic perspective.
Pradier
Olivier
O
Hematology Laboratory, Erasmus Hospital, B-1070 Brussels, Belgium.
Portois
Laurence
L
Malaisse
Willy J
WJ
Carpentier
Yvon A
YA
D000328:Adult; D015415:Biomarkers / Q000097:blood; D004655:Emulsions; D005395:Fish Oils / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D014280:Triglycerides / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*
D015415:Biomarkers; D004655:Emulsions; D005395:Fish Oils; D014280:Triglycerides