Acute generalized exanthematous pustulosis after pemetrexed, and recurrence after re-introduction.
Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous reaction, which in most cases, is related to medication. Pemetrexed is an antifolate drug, approved for treatment of metastatic non-small-cell lung cancer (NSCLC) and malignant pleural mesothelioma (MPM). We present a case of AGEP caused by pemetrexed, and a recurrence of this eruption after re-introduction of pemetrexed despite use of corticosteroids.
Bracke
A
A
University Hospital Antwerp, Antwerp, Belgium. annick.bracke@uza.be
Van Marck
E
E
Lambert
J
J
D000208:Acute Disease; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005076:Exanthema / Q000139:chemically induced* / Q000473:pathology; D005971:Glutamates / Q000009:adverse effects*; D006147:Guanine / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000068437:Pemetrexed; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology
D000964:Antimetabolites, Antineoplastic; D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine