The ever-lengthening arm of p53.
p53 is a pivotal bulwark against cancer, but exactly how it suppresses tumors remains elusive, in part because it modulates such diverse biological processes via so many downstream pathways. In a recent issue of Cell, Godar et al. (2008) now identify another string to p53's anticancer bow-repression of the CD44 cell-surface glycoproteins that coordinate many attributes of tumor progression.
Evan
Gerard I
GI
Department of Pathology, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94143-0875, USA. gevan@cc.ucsf.edu
D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000378:metabolism*
D018960:Hyaluronan Receptors; D016159:Tumor Suppressor Protein p53