title: Noncovalent interaction of 5,10,15,20-tetrakis(4-N-methylpyridyl)porphyrin with Cucurbit[7]uril: a supramolecular architecture.
abstract: Noncovalent interaction of two water-soluble synthetic macromolecules, Cucurbit[7]uril (CB7) and 5,10,15,20-tetrakis(4- N-methylpyridyl)porphyrin (TMPyP), has been studied from the viewpoint of organizing them through supramolecular interactions and thereby modulating their functional activities. Steady-state and time-resolved fluorescence measurements along with NMR results establish that CB7 crowns the N-methylpyridyl group of the TMPyP in a 1:4 stoichiometry. The overall binding constant was evaluated to be approximately 4.5 x 10 (19) M (-4). The high binding affinity, promoting a stable and extendable molecular assembly in aqueous solution, could open new frontiers in the design and synthesis of higher-order supramolecular structures with photofunctional moieties and project their utility in therapeutic applications.
authors.affiliation: Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Mumbai 400085, India. jyotim@barc.gov.in
authors.forename: Jyotirmayee
authors.initials: J
authors.lastname: Mohanty
authors.forename: Achikanath C
authors.initials: AC
authors.lastname: Bhasikuttan
authors.forename: Sharmistha Dutta
authors.initials: SD
authors.lastname: Choudhury
authors.forename: Haridas
authors.initials: H
authors.lastname: Pal