Screening of anti-HIV-1 inophyllums by HPLC-DAD of Calophyllum inophyllum leaf extracts from French Polynesia Islands.
Various pyranocoumarins, calophyllolide, inophyllums B, C, G(1), G(2) and P, from Calophyllum inophyllum (Clusiaceae) leaves of French Polynesia (Austral, Marquesas, Society and Tuamotu archipelagos) have been determined in 136 leaf extracts using a high pressure liquid chromatography-UV-diode array detection (HPLC-UV-DAD) technique. Results show a wide range in chemical composition within trees growing on eighteen islands. The use of multivariate statistical analyses (PCA) shows geographical distribution of inophyllums and indicate those rich in HIV-1 active (+)-inophyllums. Inophyllum B and P contents (0.0-39.0 and 0.0-21.8 mg kg(-1), respectively) confirm the chemodiversity of this species within the large area of French Polynesia. The study suggests the presence of interesting chemotypes which could be used as plant source for anti-HIV-1 drugs.
Laure
Frédéric
F
Biodiversité Terrestre et Marine, Université de la Polynésie Française, BP 6570, 98702 Faa'a, Tahiti, French Polynesia.
Raharivelomanana
Phila
P
Butaud
Jean-François
JF
Bianchini
Jean-Pierre
JP
Gaydou
Emile M
EM
D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D029759:Calophyllum / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D015999:Multivariate Analysis; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D011114:Polynesia; D039681:Pyranocoumarins / Q000737:chemistry / Q000494:pharmacology; D014466:Ultraviolet Rays
D019380:Anti-HIV Agents; D003374:Coumarins; D010936:Plant Extracts; D039681:Pyranocoumarins; C086091:inophyllum B; C018859:calophyllolid