title: [Comprehensive study on the risk factors of hepatitis B virus intrauterine infection].
abstract: OBJECTIVE
  To study the risk factors of hepatitis B virus (HBV) intrauterine infection.
  
  
  METHODS
  Risk factors of HBV intrauterine infection were analyzed by nested case control study.
  
  
  RESULTS
  Data from univariate analysis revealed that risk factors of HBV intrauterine infection were positive results on HLA-DR3 (OR = 4.71, 1.62-13.66), HBV DNA (OR = 6.59, 2.72-15.97) and HBeAg (OR = 4.53, 1.93-10.64) in pregnant women, HLA-DR3 (OR = 3.91, 1.18-12.94) in newborn, HLA-I) R3 (OR = 5.96, 1.14-31.15) both in pregnant women and her newborns and HBV infection in placentas (OR = 2.51,1.12-5.60). Results from Multivariate unconditional logistics regression analysis showed that the risk factors of HBV intrauterine infection were positive in both HLA-DR3 (OR = 4.65, 1.44-15.05) and HBV DNA (OR = 6.56, 2.65-16.23) in pregnant women. However, there was no interaction between the two factors. The exposure rate of other factors did not reveal the difference in the two groups. With the increase of HBV DNA in pregnant women, the risk of HBV intrauterine infection was rising (chi2 = 16.74, P < 0.05).
  
  
  CONCLUSIONS
  Risk factors of HBV intrauterine infection were HLA-DR3 positive and HBV DNA positive in pregnant women but there was no interaction between the two factors. The risk of HBV intrauterine infection was increased along with the increase of HBV DNA in pregnant women.
authors.affiliation: Department of Epidemiology, Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Yong-Liang
authors.initials: YL
authors.lastname: Feng
authors.forename: Su-Ping
authors.initials: SP
authors.lastname: Wang
authors.forename: Jun-Ni
authors.initials: JN
authors.lastname: Wei
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Shi
authors.forename: Jun-Bin
authors.initials: JB
authors.lastname: Zhang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Guo
authors.forename: Xu-Biao
authors.initials: XB
authors.lastname: Wu
authors.forename: Hua
authors.initials: H
authors.lastname: Fan
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Wang
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D015803:HLA-DR3 Antigen / Q000378:metabolism; D006509:Hepatitis B / Q000821:virology*; D006515:Hepatitis B virus / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D016015:Logistic Models; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D012307:Risk Factors
chemical_list: D004279:DNA, Viral; D015803:HLA-DR3 Antigen