title: Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis.
abstract: The risk of thromboembolism is increased in inflammatory bowel disease and its symptoms may be overlooked. Furthermore, its treatment can be complex and is not without complications. We describe a case of an adolescent boy who developed a cerebral sinus venous thrombosis during a relapse of his ulcerative colitis and who, while on treatment with heparin, developed heparin-induced thrombocytopenia (HIT). The treatment was then switched to fondaparinux, a synthetic and selective inhibitor of activated factor X.
authors.affiliation: Division of Paediatric Gastroenterology, Hepatology & Nutrition, B57 Karolinska University Hospital Stockholm Se-141 86, Sweden.
authors.forename: Gudrun Scheving
authors.initials: GS
authors.lastname: Thorsteinsson
authors.forename: Maria
authors.initials: M
authors.lastname: Magnussson
authors.forename: Lena M
authors.initials: LM
authors.lastname: Hallberg
authors.forename: Nils Gunnar
authors.initials: NG
authors.lastname: Wahlgren
authors.forename: Fredrik
authors.initials: F
authors.lastname: Lindgren
authors.forename: Petter
authors.initials: P
authors.lastname: Malmborg
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Casswall
mesh_terms: D000293:Adolescent; D003093:Colitis, Ulcerative / Q000150:complications*; D000077425:Fondaparinux; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D020767:Intracranial Thrombosis / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D011134:Polysaccharides / Q000627:therapeutic use; D012307:Risk Factors; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis; D020246:Venous Thrombosis / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D011134:Polysaccharides; D006493:Heparin; D000077425:Fondaparinux