title: The MAO-A genotype does not modulate resting brain metabolism in adults.
abstract: Variation in the monoamine-oxidase-A (MAO-A) gene has been associated with volumetric changes in corticolimbic regions with differences in their response to relevant emotional tasks. Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype.
authors.affiliation: Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States. nellyklein@bnl.gov
authors.forename: Nelly
authors.initials: N
authors.lastname: Alia-Klein
authors.forename: Aarti
authors.initials: A
authors.lastname: Kriplani
authors.forename: Kith
authors.initials: K
authors.lastname: Pradhan
authors.forename: Jim Yeming
authors.initials: JY
authors.lastname: Ma
authors.forename: Jean
authors.initials: J
authors.lastname: Logan
authors.forename: Benjamin
authors.initials: B
authors.lastname: Williams
authors.forename: Ian W
authors.initials: IW
authors.lastname: Craig
authors.forename: Frank
authors.initials: F
authors.lastname: Telang
authors.forename: Dardo
authors.initials: D
authors.lastname: Tomasi
authors.forename: Rita Z
authors.initials: RZ
authors.lastname: Goldstein
authors.forename: Gene-Jack
authors.initials: GJ
authors.lastname: Wang
authors.forename: Nora D
authors.initials: ND
authors.lastname: Volkow
authors.forename: Joanna S
authors.initials: JS
authors.lastname: Fowler
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology* / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D005838:Genotype; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008032:Limbic System / Q000378:metabolism; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D049268:Positron-Emission Tomography
chemical_list: D008995:Monoamine Oxidase; D005947:Glucose