Cytologic characteristics of intracytoplasmic refractile eosinophilic granular bodies in anaplastic oligodendroglioma: a case report.
BACKGROUND
Oligodendrogliomas, which have a relatively better prognosis than tumors of the astrocytic lineage, have few morphologic clues for diagnosis.


METHODS
To address this problem, eosinophilic refractile inclusions were examined cytologically in the tumor of a 59-year-old man, using surgical materials for rapid diagnosis. Cytologic, histologic, and immunohistochemical findings were compatible with the refractile eosinophilic inclusions found in oligodendroglial tumors. The tumor cells presented a sheet-like epithelial pattern, forming no overlapping cell clusters, with an ill-defined cytoplasmic membrane, and nuclei that appeared to be naked, approximately 2 times the size of a red blood cell (approximately 7 microm) in diameter. It was easier to examine the cells and inclusions by cytologic preparations than by histology.


CONCLUSIONS
The inclusions were thought to be a diagnostic clue for oligodendrogliomas, especially on cytology, and cytology was more useful than histology.
Kojima
Hideaki
H
Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan. hkojima-path@umin.net
Mori
Kazuma
K
Fukudome
Nobuyuki
N
Iseki
Masachika
M
Shimizu
Seichiro
S
D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D003594:Cytoplasmic Granules / Q000473:pathology*; D004804:Eosinophils / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009778:Occipital Lobe / Q000473:pathology*; D009837:Oligodendroglioma / Q000473:pathology* / Q000628:therapy