title: Reduced interleukin-5 production by peripheral CD4+ T cells in common variable immunodeficiency patients.
abstract: We evaluated the capacity of peripheral CD4+ T helper cells in four Common Variable Immunodeficiency (CVI) patients to secrete interleukin-4 (IL-4) and IL-5. While in control CD4+ T cells, stimulated via CD3 and cultured in presence of IL-2 or IL-15, a 10 fold increased production of IL-5 (146 +/- 30; 142 +/- 25 pg/ml) was found, a 4 fold increment of this cytokine was, instead, detected in 3 out of 4 CVI patients (34 +/- 13; 39 +/- 12 pg/ml) (p < 0.05). In conclusion, the reduction of IL-5, involved in the late regulation of B cell differentiation into Ig-secreting plasma cells, may contribute to the defective antibody production in CVI patients.
authors.affiliation: Department of Biomedicine of the Development Age, University of Bari, Bari, Italy.
authors.forename: Giovanni Carlo
authors.initials: GC
authors.lastname: Del Vecchio
authors.forename: Baldassarre
authors.initials: B
authors.lastname: Martire
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lassandro
authors.forename: Valerio
authors.initials: V
authors.lastname: Cecinati
authors.forename: Delia
authors.initials: D
authors.lastname: De Mattia
authors.forename: Maria
authors.initials: M
authors.lastname: Ciccarelli
authors.forename: Laura
authors.initials: L
authors.lastname: Piacente
authors.forename: Paola
authors.initials: P
authors.lastname: Giordano
mesh_terms: D000293:Adolescent; D000328:Adult; D000921:Antibody-Producing Cells / Q000378:metabolism / Q000473:pathology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D002478:Cells, Cultured; D002648:Child; D017074:Common Variable Immunodeficiency / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D015536:Down-Regulation / Q000276:immunology*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis / Q000172:deficiency; D015848:Interleukin-5 / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D008297:Male; D010950:Plasma Cells / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
chemical_list: C508599:IL5 protein, human; D007136:Immunoglobulins; D015848:Interleukin-5