Factors responsible for elevation of 1-h postchallenge plasma glucose levels in Japanese men.
The 1-h postchallenge plasma glucose (1-h PG) level is considered to be a good index of the development of glucose intolerance and type 2 diabetes as well as of diabetic complications. In some cases, in Japanese, 1-h PG is elevated despite normal fasting glucose during oral glucose tolerance test (OGTT), but the factors responsible remain unclear. In the present study, subjects with normal glucose tolerance (NGT), isolated impaired fasting glucose (IFG), and isolated impaired glucose tolerance (IGT) were divided into subgroups at 1-h PG of 10.0mM, and the four indices of insulin secretion and insulin sensitivity were compared. In all three categories, the insulinogenic index in subjects with elevated 1-h PG was remarkably lower than in those without elevated 1-h PG. In addition, the insulinogenic index was the strongest factor in elevated 1-h PG according to the multiple regression analysis. Interestingly, one third of the NGT subjects enrolled in this study had elevated 1-h PG. These subjects showed significantly elevated area under the curve of glucose (G-AUC) compared to NGT subjects without 1-h PG elevation. Thus, elevated 1-h PG in Japanese subjects indicates mildly impaired glucose tolerance due to decreased early-phase insulin secretion.
Harada
Norio
N
Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Fukushima
Mitsuo
M
Toyoda
Kentaro
K
Mitsui
Rie
R
Izuka
Tomoyo
T
Taniguchi
Ataru
A
Nakai
Yoshikatsu
Y
Yamada
Yuichiro
Y
Seino
Yutaka
Y
Inagaki
Nobuya
N
D001786:Blood Glucose / Q000235:genetics*; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism / Q000494:pharmacology; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism; D007564:Japan; D008055:Lipids / Q000097:blood; D008297:Male; D012044:Regression Analysis
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids