title: A systematic review of silver-releasing dressings in the management of infected chronic wounds.
abstract: OBJECTIVE
  This paper is a systematic review with the objective of determining the effectiveness of silver-releasing dressing in the management of infected chronic wounds.
  
  
  BACKGROUND
  Chronic wounds exhibit increased bacterial burdens which not only result in a negative physical impact on patients, impairing their quality of life, but also increase treatment costs. Silver dressings are wound products designed to control and inhibit infection and provide a wound environment conducive to healing. However, there is limited evidence on their effectiveness in doing so.
  
  
  METHODS
  A systematic review of literature from 1950-May 2007 was conducted using the PubMed, CINAHL, Cochrane, MEDLINE, British Nursing Index, EBSCO Host, OCLC, Proquest and PsychInfo databases. The review included randomised or non-randomised control trials, published in English or non-English, of silver-releasing dressings in infected chronic wounds.
  
  
  RESULTS
  Of the over 1957 potentially releasing studies examined, 14 pertinent articles involving 1285 participants were identified. Almost all the participants reported one or more statistically significant outcomes. The main points to emerge from this review of studies are that silver-releasing dressings show positive effects on infected chronic wounds. The quality of the trials was limited by the potential for bias associated with inadequate concealment, no detailed description of the outcome measurement and no reported intention-to-treat analysis. Moreover, problems existed in some studies with confounding factors.
  
  
  CONCLUSIONS
  The review clearly highlights the need for well-designed, methodologically standardised outcome measurement research into the effectiveness of silver-releasing dressings. It also points to the need for a comprehensive assessment of wound bed status in further studies.
  
  
  CONCLUSIONS
  This review strengthens the case for the use of silver dressings when managing infected chronic wounds. They appear more effective and are tolerated well by patients. However, their use should be accompanied by a comprehensive wound assessment.
authors.affiliation: Department of Nursing, Tzu Chi College of Technology, Buddhist Tzu Chi General Hospital and School and Graduate Institute of Nursing, National Taiwan University, Taipei, Taiwan. d92426003@yahoo.com.tw
authors.forename: Shu-Fen
authors.initials: SF
authors.lastname: Lo
authors.forename: Mark
authors.initials: M
authors.lastname: Hayter
authors.forename: Chee-Jen
authors.initials: CJ
authors.lastname: Chang
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Hu
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Lee
mesh_terms: D001458:Bandages / Q000592:standards*; D015982:Bias; D002908:Chronic Disease; D015400:Clinical Nursing Research; D018849:Controlled Clinical Trials as Topic; D003362:Cost-Benefit Analysis; D019317:Evidence-Based Medicine; D005122:Exudates and Transudates; D006801:Humans; D017053:Infection Control; D009812:Odorants; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D018030:Silver Compounds / Q000627:therapeutic use*; D017592:Skin Care / Q000191:economics / Q000295:instrumentation* / Q000451:nursing; D016896:Treatment Outcome; D014945:Wound Healing; D014946:Wound Infection / Q000628:therapy*
chemical_list: D018030:Silver Compounds