title: Hypothyroidism induces selective oxidative stress in amygdala and hippocampus of rat.
abstract: The effects of hypothyroidism on lipid peroxidation (LP), reactive oxygen species (ROS), and nitric oxide synthase (NOS), levels and expression, in rat brain were examined. Hypothyroidism was induced by administering methimazole in drinking water (60 mg/kg/day). In striatum, motor cortex and cerebellum of hypothyroid rats LP was not modified, whereas LP and ROS increased in amygdala and hippocampus of hypothyroid rats at the third week of treatment with methimazole as compared to euthyroid group values. Regarding NOS participation, only hippocampal constitutive-NOS activity was increased, accompanied by an augmentation in nNOS expression. Results show that hypothyroidism induces selective oxidative stress in both the hippocampus and amygdala, where the nitrergic system is involved.
authors.affiliation: Departamento de Fisiología "Mauricio Russek", Escuela Nacional de Ciencias Biológicas, IPN, Prol. Carpio y Plan de Ayala, s/n, cp. 11340 Mexico City, Mexico.
authors.forename: Edgar
authors.initials: E
authors.lastname: Cano-Europa
authors.forename: Francisca
authors.initials: F
authors.lastname: Pérez-Severiano
authors.forename: Paula
authors.initials: P
authors.lastname: Vergara
authors.forename: Rocío
authors.initials: R
authors.lastname: Ortiz-Butrón
authors.forename: Camilo
authors.initials: C
authors.lastname: Ríos
authors.forename: José
authors.initials: J
authors.lastname: Segovia
authors.forename: Jorge
authors.initials: J
authors.lastname: Pacheco-Rosado
mesh_terms: D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D013956:Antithyroid Agents; D001831:Body Temperature / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism*; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008713:Methimazole; D052248:Nitric Oxide Synthase Type I / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D013956:Antithyroid Agents; D017382:Reactive Oxygen Species; D008713:Methimazole; D052248:Nitric Oxide Synthase Type I; D052250:Nitric Oxide Synthase Type III