Linezolid activity against disseminated Listeria monocytogenes meningitis and central nervous system abscesses: focus on early drug myelotoxicity.
A very infrequent report of Listeria monocytogenes meningitis and multiple subtentorial abscesses (cerebellar, bulbar, and pontine in location), occurred in an immunocompetent man, and is described and discussed on the ground of the most recent literature evidences regarding the frequency, presentation, and outcome of this disease. The possibility to resort to combination linezolid therapy in patients who appear to be not responsive to first-line treatment of cerebral abscess of definite origin, and the appearance of anemia as an early untoward event of this novel oxazolidinone antibiotic, are also debated.
Manfredi
Roberto
R
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy. Roberto.manfredi@unibo.it
D000081:Acetamides / Q000009:adverse effects* / Q000627:therapeutic use*; D000740:Anemia / Q000139:chemically induced; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D001922:Brain Abscess / Q000188:drug therapy* / Q000382:microbiology; D001933:Brain Stem / Q000000981:diagnostic imaging / Q000382:microbiology; D002526:Cerebellar Diseases / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007121:Immunocompetence; D000069349:Linezolid; D008279:Magnetic Resonance Imaging; D008297:Male; D008584:Meningitis, Listeria / Q000188:drug therapy* / Q000382:microbiology; D000077731:Meropenem; D008875:Middle Aged; D023303:Oxazolidinones / Q000009:adverse effects* / Q000627:therapeutic use*; D013845:Thienamycins / Q000009:adverse effects / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D013845:Thienamycins; D000077731:Meropenem; D000069349:Linezolid