title: [Impact of mild hypertension on the risks of cardiovascular disease: the Hisayama Study].
abstract: In a long-term epidemiological study of cerebro-cardiovascular diseases (CVD) in the town of Hisayama, the prevalence of mild hypertension (140-159/90-99 mmHg) significantly increased from 1961 to 1988, while that of moderate to severe hypertension (> or = 160/100 mmHg) decreased during this period due to the popularization of antihypertensive management. A 32-year follow-up study of Hisayama elderly residents revealed that the risk of CVD rose progressively with elevating blood pressure levels, and mild hypertension was a significant risk factor for CVD occurrence. This association was observed in age groups of 60s to 70s years and in both subjects with and without target organ damages or glucose intolerance. Effective treatment strategies are necessary for mild hypertension as well as moderate-severe hypertension.
authors.affiliation: Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University.
authors.forename: Hisatomi
authors.initials: H
authors.lastname: Arima
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kiyohara
mesh_terms: D000367:Age Factors; D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012306:Risk; D012720:Severity of Illness Index; D020521:Stroke / Q000453:epidemiology / Q000209:etiology; D013997:Time Factors