title: Visualization of CYP2D6 genotype to phenotype correlation in Korean.
abstract: Cytochrome P450 2D6 (CYP2D6) shows high extent of genotypic and phenotypic polymorphism, which causes inter-individual variation in drug disposition of many therapeutic drugs. Genotype and phenotype of CYP2D6 were determined in 130 Koreans. To visualize the genotype-to-phenotype correlation at a glance, a colored map based on CYP2D6 phenotype was created using two cluster algorithms and annotated for CYP2D6 genotypes. The findings with those algorithms were similar to previous study,which suggests the possibility to use this information in individualizing therapy based on the genotype.
authors.affiliation: Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Korea.
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Kim
authors.forename: Hyun-Ju
authors.initials: HJ
authors.lastname: Jung
authors.forename: Sang-Seop
authors.initials: SS
authors.lastname: Lee
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Shon
authors.forename: Sang-Goo
authors.initials: SG
authors.lastname: Shin
authors.forename: Jae-Gook
authors.initials: JG
authors.lastname: Shin
mesh_terms: D000465:Algorithms; D016000:Cluster Analysis; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D003626:Data Display; D005838:Genotype; D006801:Humans; D007723:Korea; D010597:Pharmacogenetics; D010641:Phenotype
chemical_list: D019389:Cytochrome P-450 CYP2D6