title: Levels of bisphenol A in canned liquid infant formula products in Canada and dietary intake estimates.
abstract: A sensitive, efficient, and reproducible method, based on solid phase extraction and derivatization with acetic anhydride followed by gas chromatography-mass spectrometry in selected-ion monitoring mode, was developed for the determination of bisphenol A (BPA) in liquid infant formula. The method quantification limit was 0.5 ng g(-1). Extraction recoveries were 85-94% over the concentration range of 2.5-20 ng g(-1). Good reproducibility of the method was observed at levels of 0.54 and 10.4 ng g(-1) with relative standard deviations of 5.0 and 2.8%, respectively. The method was used to analyze samples of 21 canned liquid infant formula products for BPA. BPA was detected in all samples at levels ranging from as low as 2.27 ng g(-1) to as high as 10.2 ng g(-1). The probable daily intakes of BPA due to consumption of canned liquid infant formula were estimated for infants from premature to 12-18 months of age. The maximum probable daily intake of BPA was 1.35 microg kg(-1) of body weight day(-1) for 0-1-month-old infants with the maximum formula intake, which is below the provisional tolerable daily intake for BPA established by Health Canada, 25 microg kg(-1) of body weight day(-1).
authors.affiliation: Food Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, 251 Frederick Banting Driveway, AL: 2203D, Ottawa, Ontario, Canada K1A 0L2. xu-liang_cao@hc-sc.gc.ca
authors.forename: Xu-Liang
authors.initials: XL
authors.lastname: Cao
authors.forename: Guy
authors.initials: G
authors.lastname: Dufresne
authors.forename: Stephane
authors.initials: S
authors.lastname: Belisle
authors.forename: Genevieve
authors.initials: G
authors.lastname: Clement
authors.forename: Mirka
authors.initials: M
authors.lastname: Falicki
authors.forename: Franca
authors.initials: F
authors.lastname: Beraldin
authors.forename: Anastase
authors.initials: A
authors.lastname: Rulibikiye
mesh_terms: D001559:Benzhydryl Compounds; D002170:Canada; D004032:Diet; D005506:Food Contamination / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000737:chemistry*; D007231:Infant, Newborn; D007234:Infant, Premature; D010636:Phenols / Q000032:analysis*; D011786:Quality Control; D015203:Reproducibility of Results; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds