title: Antileishmanial activity of aldonamides and N-acyl-diamine derivatives.
abstract: A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC50 against L. chagasi below 5 microM.
authors.affiliation: Departamento de Parasitologia, Microbiologia e Imunologia, Instituto de CiênciasBiológicas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900, Juiz de Fora, MG, Brazil. elaine.coimbra@ufjf.edu.br
authors.forename: Elaine S
authors.initials: ES
authors.lastname: Coimbra
authors.forename: Camila G
authors.initials: CG
authors.lastname: Almeida
authors.forename: Wilson V
authors.initials: WV
authors.lastname: Júnior
authors.forename: Roberta C N
authors.initials: RC
authors.lastname: Dos Reis
authors.forename: Ana C F
authors.initials: AC
authors.lastname: De Almeida
authors.forename: Luana S M
authors.initials: LS
authors.lastname: Forezi
authors.forename: Mauro V
authors.initials: MV
authors.lastname: De Almeida
authors.forename: Mireille
authors.initials: M
authors.lastname: Le Hyaric
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D003959:Diamines / Q000737:chemistry / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000577:Amides; D003959:Diamines; D014344:Trypanocidal Agents