title: Pseudolymphomatous angiokeratoma: report of three cases and an immunohistological study.
abstract: BACKGROUND
  Pseudolymphomatous angiokeratoma (PA), originally termed 'acral pseudolymphomatous angiokeratoma of children', is a disorder characterized clinically by development of red nodules on the extremities and histologically by a subepidermal dense lymphocyte infiltrate.
  
  
  METHODS
  We report three cases of PA, with characteristically dense, nodular infiltrate composed predominantly of small lymphocytes, and thick-walled vessels.
  
  
  RESULTS
  Immunohistochemical investigation revealed a dense accumulation of CD20+ cells with CD3+ cells in one case. Infiltrate in the other two cases was mainly composed of CD3+ cells and a mixture of CD4+ and CD8+ cells, with a few cells expressing CD20.
  
  
  CONCLUSIONS
  Our immunohistological results reveal a wide spectrum of cellular infiltrate compositions ranging from T-cell to B-cell predominance.
authors.affiliation: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan. rokuyama@mail.tains.tohoku.ac.jp
authors.forename: R
authors.initials: R
authors.lastname: Okuyama
authors.forename: T
authors.initials: T
authors.lastname: Masu
authors.forename: M
authors.initials: M
authors.lastname: Mizuashi
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Tagami
authors.forename: S
authors.initials: S
authors.lastname: Aiba
mesh_terms: D000328:Adult; D000794:Angiokeratoma / Q000276:immunology / Q000473:pathology*; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007150:Immunohistochemistry; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D055815:Young Adult