Comparative effects of atorvastatin and simvastatin on the plasma total homocysteine levels in women with polycystic ovary syndrome: a prospective randomized study.
OBJECTIVE
To test the hypothesis that statins improve hyperhomocysteinemia in women with polycystic ovary syndrome (PCOS).


METHODS
A prospective randomized study.


METHODS
University Hospital.


METHODS
Fifty-two women with PCOS and 52 women matched for age and body mass index as controls.


METHODS
Patients were randomly divided into two groups for treatment: group 1, atorvastatin, 20 mg daily (n = 26), and group 2, simvastatin, 20 mg daily (n = 26). Blood samples were obtained before and after treatment.


METHODS
Serum homocysteine levels.


RESULTS
After 12 weeks of treatment, serum homocysteine levels in group 1 had decreased from 14.3 +/- 2.9 to 10.6 +/- 1.7 micromol/L; in group 2, the levels decreased from 13.6 +/- 2.1 to 11.1 +/- 1.9 micromol/L. Both two groups, free testosterone and total testosterone declined statistically significantly (38.3% and 36.5%; and 40.6% and 46.0%, respectively). In group 1, vitamin B(12) increased from 362.1 +/- 107 to 478.7 +/- 267 pg/mL; in group 2, it increased from 391.3 +/- 107 to 466 +/- 211 pg/mL, but the change did not reach statistical significance. There was a considerable decline in the homeostatic model assessment index in group 1 (40.0% to 32.1%).


CONCLUSIONS
Treatment with statins in women with PCOS leads to decreases in serum homocysteine levels.
Kaya
Cemil
C
Department of Obstetrics and Gynecology, Ufuk University, Ankara, Turkey. kayacemil000@yahoo.com
Cengiz
Sevim Dinçer
SD
Berker
Bülent
B
Demirtaş
Selda
S
Cesur
Mustafa
M
Erdoğan
Gürbüz
G
D000328:Adult; D000924:Anticholesteremic Agents / Q000008:administration & dosage; D000069059:Atorvastatin; D005260:Female; D006538:Heptanoic Acids / Q000008:administration & dosage*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D008657:Metabolic Clearance Rate / Q000187:drug effects; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D011758:Pyrroles / Q000008:administration & dosage*; D012189:Retrospective Studies; D019821:Simvastatin / Q000008:administration & dosage*; D016896:Treatment Outcome
D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D011758:Pyrroles; D006710:Homocysteine; D000069059:Atorvastatin; D019821:Simvastatin