Substitution behaviour of amine-bridged dinuclear Pt(II) complexes with bio-relevant nucleophiles.
Complexes of the type [Pt2(N,N,N',N'-tetrakis(2-pyridylmethyl)diamine(HO)2]4+ and [Pt2(N,N,N',N'-tetrakis(2-pyridylmethyl)diamine(Cl)2]2+ were used to study their reactions with a series of bio-relevant nucleophiles, viz. thiourea, L-methionine and guanosine-5'-monophosphate (5'-GMP2-) as a function of nucleophile concentration and temperature. The reactions with the sulfur containing nucleophiles (thiourea and L-methionine) were followed under pseudo-first-order conditions by stopped-flow and UV-Vis spectrophotometry. The reaction with 5'-GMP2- was carried out under second order conditions and studied by NMR spectroscopy. The results indicate that the bridged dinuclear complexes remain intact after coordination of the studied nucleophiles for an extended period of time, which differs significantly from that reported for other multinuclear platinum complexes in the literature.
Ertürk
Hakan
H
Inorganic Chemistry, Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Egerlandstr. 1, 91058 Erlangen, Germany.
Maigut
Joachim
J
Puchta
Ralph
R
van Eldik
Rudi
R
D000588:Amines / Q000737:chemistry*; D002413:Cations, Divalent; D006157:Guanosine Monophosphate / Q000737:chemistry; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008715:Methionine / Q000737:chemistry; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D013890:Thiourea / Q000737:chemistry
D000588:Amines; D002413:Cations, Divalent; D009944:Organoplatinum Compounds; D010984:Platinum; D006157:Guanosine Monophosphate; D008715:Methionine; D013890:Thiourea