Integrin-linked kinase: a potential therapeutic target for the treatment of glioma.
The diffuse infiltrative nature of cerebral glioma is a primary reason for failure of current treatment regimes. An improved understanding of the molecular determinants of tumour invasion is imperative in order to achieve therapeutic advances. Integrin-linked kinase has been shown to be key in the regulation of cell migration, as well as proliferation and apoptosis. The involvement of integrin-linked kinase in glioma biology, and its potential as a possible therapeutic target, is discussed.
D'Abaco
Giovanna M
GM
Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, Victoria, Australia. Giovanna.Dabaco@mh.org.au
Kaye
Andrew H
AH
D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005910:Glioma / Q000188:drug therapy / Q000201:enzymology*; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship; D000099200:Scaffold Protein ILK
D000964:Antimetabolites, Antineoplastic; D004791:Enzyme Inhibitors; D017346:Protein Serine-Threonine Kinases; D000099200:Scaffold Protein ILK