title: Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor.
abstract: The phosphopantetheinyl transferase genes SCO5883 (redU) and SCO6673 were disrupted in Streptomyces coelicolor. The redU mutants did not synthesize undecylprodigiosin, while SCO6673 mutants failed to produce calcium-dependent antibiotic. Neither gene was essential for actinorhodin production or morphological development in S. coelicolor, although their mutation could influence these processes.
authors.affiliation: Department of Chemistry, Williams College, 47 Lab Campus Dr., Williamstown, MA 01267, USA.
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Lu
authors.forename: Adrianna K
authors.initials: AK
authors.lastname: San Roman
authors.forename: Amy M
authors.initials: AM
authors.lastname: Gehring
mesh_terms: D000880:Anthraquinones / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D017353:Gene Deletion; D016254:Mutagenesis, Insertional; D010455:Peptides / Q000378:metabolism*; D011353:Prodigiosin / Q000031:analogs & derivatives / Q000096:biosynthesis; D048372:Streptomyces coelicolor / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D017855:Transferases (Other Substituted Phosphate Groups) / Q000235:genetics / Q000378:metabolism*; D000095622:Benzoisochromanequinones
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D010455:Peptides; D011353:Prodigiosin; D017855:Transferases (Other Substituted Phosphate Groups); C040487:CDA antibiotic; C082662:phosphopantetheinyl transferase; C047347:undecylprodigiosin; C013390:actinorhodin; D000095622:Benzoisochromanequinones