Exploiting cross-amyloid interactions to inhibit protein aggregation but not function: nanomolar affinity inhibition of insulin aggregation by an IAPP mimic.
Velkova
Aleksandra
A
Laboratory of Peptide Biochemistry, Center for Integrated Protein Science München, Technische Universität München, An der Saatzucht 5, 85350 Freising-Weihenstephan, Germany.
Tatarek-Nossol
Marianna
M
Andreetto
Erika
E
Kapurniotu
Aphrodite
A
D000595:Amino Acid Sequence; D000682:Amyloid / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D045744:Cell Line, Tumor; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D018716:Molecular Mimicry; D008969:Molecular Sequence Data
C509234:(N-Me)G24, (N-Me)I26-IAPP; D000682:Amyloid; D007328:Insulin