title: In situ quantitative measurement of concentration profiles in a microreactor with submicron resolution using multiplex CARS microscopy.
abstract: In situ quantitative imaging of concentration profiles of reactants and products inside a microfluidic reactor is achieved, with submicron spatial resolution with mM sensitivity and on ms time scales, for a given position. The label-free approach relies on quantitative vibrational spectroscopy, using Coherent Anti-Stokes Raman scattering microscopy in a spectrally resolved fashion, and is demonstrated on an elementary acid-base reaction.
authors.affiliation: Department of Physics, Colorado School of Mines, 1523 Illinois Street, Golden, Colorado 80401, USA.
authors.forename: Dawn
authors.initials: D
authors.lastname: Schafer
authors.forename: Jeff A
authors.initials: JA
authors.lastname: Squier
authors.forename: Jan
authors.initials: J
authors.lastname: van Maarseveen
authors.forename: Daniel
authors.initials: D
authors.lastname: Bonn
authors.forename: Mischa
authors.initials: M
authors.lastname: Bonn
authors.forename: Michiel
authors.initials: M
authors.lastname: Müller
mesh_terms: D019342:Acetic Acid / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D011759:Pyrrolidines / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D011759:Pyrrolidines; C032519:pyrrolidine; D019342:Acetic Acid