title: Association of estrogen receptor alpha and interleukin-10 gene polymorphisms with endometriosis in a Chinese population.
abstract: OBJECTIVE
  To determine whether polymorphisms of the estrogen receptor alpha (ERalpha) and interleukin-10 (IL-10) genes are associated with endometriosis in a Chinese population.
  
  
  METHODS
  Association study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Chinese women diagnosed with endometriosis by laparotomy or laparoscopy.
  
  
  METHODS
  Determination of polymorphisms of the ERalpha and IL-10 genes was performed by polymerase chain reaction and restriction fragment length polymorphism analysis in 214 affected women and 160 controls.
  
  
  METHODS
  Frequency and distribution of PvuII and XbaI polymorphisms of ERalpha and of BslI, SspI, and RsaI polymorphisms of IL-10.
  
  
  RESULTS
  There was no significant difference between the endometriosis patients and the control groups in the genotype frequency of ERalpha-PvuII and promoter of IL-10 gene polymorphisms in the position of -1082. However, the frequency of ERalpha-XbaI and -592 or -819C alleles of IL-10 in the endometriosis group was significantly higher than that of controls, and further analysis showed that the X allele of ERalpha-XbaI was associated with endometriosis.
  
  
  CONCLUSIONS
  The X allele of ERalpha-XbaI and the -592 or -819 C allele of IL-10 are associated with endometriosis.
authors.affiliation: Central Laboratory of Nanjing First Hospital affiliated to Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Jingyan
authors.initials: J
authors.lastname: Xie
authors.forename: Shukui
authors.initials: S
authors.lastname: Wang
authors.forename: Bangshun
authors.initials: B
authors.lastname: He
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Pan
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Li
authors.forename: Qingdi
authors.initials: Q
authors.lastname: Zeng
authors.forename: Huaxin
authors.initials: H
authors.lastname: Jiang
authors.forename: Jialiang
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D002681:China; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D017931:DNA Primers; D004715:Endometriosis / Q000235:genetics* / Q000601:surgery*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D010535:Laparoscopy; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012016:Reference Values; D055815:Young Adult
chemical_list: D017931:DNA Primers; D047628:Estrogen Receptor alpha; D016753:Interleukin-10; D004247:DNA