B-type natriuretic peptide is related to histological skeletal muscle abnormalities in patients with chronic heart failure.
This study examined the potential association between skeletal muscle histological findings and circulating levels of N-terminal Atrial natriuretic peptide (NT-proANP) and N-terminal B-type natriuretic peptide (NT-proBNP) at rest and during exercise in patients with moderate chronic heart failure. We report a significant correlation between muscle fibre roundness, defined as ratio of fibre perimeter squared to fibre area, and plasma levels of N-BNP. This finding suggests that the degree of intrafibrillar edema is related to the secretion of NT-proBNP.
Larsen
Alf Inge
AI
Department of Cardiology, Stavanger University Hospital, Norway. laai@sus.no
Skadberg
Øyvind
Ø
Aarsland
Torbjørn
T
Kvaløy
Jan Terje
JT
Lindal
Sigurd
S
Omland
Torbjørn
T
Dickstein
Kenneth
K
D000368:Aged; D002908:Chronic Disease; D006333:Heart Failure / Q000097:blood* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000473:pathology*; D020097:Natriuretic Peptide, Brain / Q000097:blood*
D020097:Natriuretic Peptide, Brain