Effects of protein versus simple sugar intake on weight loss in polycystic ovary syndrome (according to the National Institutes of Health criteria).
OBJECTIVE
To compare the effects of protein vs. simple sugars on weight loss, body composition, and metabolic and endocrine parameters in polycystic ovary syndrome (PCOS).


METHODS
A 2-month, free-living, randomized, single-blinded study.


METHODS
University PCOS clinic.


METHODS
Thirty-three patients with PCOS.


METHODS
To achieve a final energy reduction of 450 kcal/day, first the daily energy intake was reduced by 700 kcal; then a 240-kcal supplement containing either whey protein or simple sugars was added.


METHODS
Changes in weight, fat mass, fasting glucose and insulin, plasma lipoproteins, and sex steroids.


RESULTS
Twenty-four subjects (13 in the simple sugars group and 11 in the protein group) completed the study. The protein group lost more weight (-3.3 +/- 0.8 kg vs. -1.1 +/- 0.6 kg) and more fat mass (-3.1 +/- 0.9 kg vs. -0.5 +/- 0.6 kg) and had larger decreases in serum cholesterol (-33.0 +/- 8.4 mg/dL vs. -2.3 +/- 6.8 mg/dL), high-density lipoprotein cholesterol (-4.5 +/- 1.3 mg/dL vs. -0.4 +/- 1.3 mg/dL), and apoprotein B (-20 +/- 5 mg/dL vs. 3 +/- 5 mg/dL).


CONCLUSIONS
In patients with PCOS, a hypocaloric diet supplemented with protein reduced body weight, fat mass, serum cholesterol, and apoprotein B more than the diet supplemented with simple sugars.
Kasim-Karakas
Sidika E
SE
Division of Endocrinology, Clinical Nutrition and Vascular Medicine, Department of Internal Medicine, The University of California-Davis, 4150 V Street, Sacramento, CA 95817, USA. sekarakas@ucdavis.edu
Almario
Rogelio U
RU
Cunningham
Wendy
W
D000293:Adolescent; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D002151:Calorimetry; D004038:Diet, Reducing; D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D019422:Dietary Sucrose; D002149:Energy Intake; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D009316:National Institutes of Health (U.S.); D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000503:physiopathology*; D016037:Single-Blind Method; D014481:United States; D015431:Weight Loss; D055815:Young Adult
D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D019422:Dietary Sucrose; D020738:Leptin