[Drug-induced liver injury caused by an herbal medicine, bofu-tsu-sho-san].
A 37-year-old woman was admitted to a hospital with jaundice. Within a couple of weeks, her liver function improved with only symptomatic therapy. About 30 to 60 days before admission, she had taken a herbal medicine, bofu-tsu-sho-san. A diagnosis of drug-induced liver injury was made according to the diagnostic scale proposed at the Digestive Disease Week-Japan 2004. A drug-lymphocyte stimulation test for each ingredient of bofu-tsu-sho-san; the results were positive for Cnidii Rhizoma, Angelicae Radix and Menthae Herba. The liver biopsy specimen revealed features of acute hepatitis. Physicians should be aware that bofu-tsu-sho-san can cause liver injury, as this drug is commonly used as an over-the-counter medicine.
Motoyama
Hiroyuki
H
Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan.
Enomoto
Masaru
M
Yasuda
Takahiro
T
Fujii
Hideki
H
Kobayashi
Sawako
S
Iwai
Shuji
S
Morikawa
Hiroyasu
H
Takeda
Tadashi
T
Tamori
Akihiro
A
Sakaguchi
Hiroki
H
Kawada
Norifumi
N
D000208:Acute Disease; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D004366:Nonprescription Drugs / Q000009:adverse effects*; D009765:Obesity / Q000188:drug therapy*; D008517:Phytotherapy / Q000009:adverse effects*; D012651:Self Medication / Q000009:adverse effects*
D004365:Drugs, Chinese Herbal; D004366:Nonprescription Drugs; C098310:bofu-tsusho-san