Comparison of protocols efficacy in poor responders: differences in oocytes/embryos competence with different protocols, a retrospective study.
At present, there is no agreement on poor ovarian response definition, and no definitive evidence that this prognosis can be changed by a specific protocol. Our data suggest that a flare-up protocol with a depot gonadotropin-releasing hormone (GnRH) agonist formulation gives higher total pregnancy and implantation rates than a GnRH antagonist, possibly by improving oocyte/embryo competence.
Manno
Massimo
M
Maternal-Pediatric Department, Pordenone Hospital, Pathophysiology Unit of Human Reproduction and Sperm Bank, Pordenone, Italy. massimo.manno@aopn.fvg.it
Tomei
Francesco
F
Cervi
Marta
M
Favretti
Cristina
C
Adamo
Valter
V
D000328:Adult; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D002985:Clinical Protocols; D004305:Dose-Response Relationship, Drug; D004624:Embryo Transfer; D047108:Embryonic Development / Q000502:physiology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000037:antagonists & inhibitors*; D006801:Humans; D008186:Luteolytic Agents / Q000494:pharmacology; D009865:Oocytes / Q000187:drug effects / Q000502:physiology*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D017329:Triptorelin Pamoate / Q000494:pharmacology
D006063:Chorionic Gonadotropin; D008186:Luteolytic Agents; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone