title: The lectin-like activity of human C1q and its implication in DNA and apoptotic cell recognition.
abstract: C1q, the binding subunit of the C1 complex of complement, is an archetypal pattern recognition molecule known for its striking ability to recognize a wide variety of targets, ranging from pathogenic non self to altered self. DNA is one of the C1q ligands, but the precise region of C1q and the DNA motifs that support interaction have not been characterized yet. Here, we report for the first time that the peripheral globular region of the C1q molecule displays a lectin-like activity, which contributes to DNA binding through interaction with its deoxy-d-ribose moiety and may participate in apoptotic cell recognition.
authors.affiliation: Institut de Biologie Structurale Jean-Pierre Ebel, F-38027 Grenoble Cedex 1, France.
authors.forename: Helena
authors.initials: H
authors.lastname: Païdassi
authors.forename: Pascale
authors.initials: P
authors.lastname: Tacnet-Delorme
authors.forename: Thomas
authors.initials: T
authors.lastname: Lunardi
authors.forename: Gérard J
authors.initials: GJ
authors.lastname: Arlaud
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Thielens
authors.forename: Philippe
authors.initials: P
authors.lastname: Frachet
mesh_terms: D017209:Apoptosis; D001665:Binding Sites; D015922:Complement C1q / Q000235:genetics / Q000378:metabolism*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D024202:Electrophoretic Mobility Shift Assay; D006601:Hexoses / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D010429:Pentoses / Q000737:chemistry / Q000378:metabolism
chemical_list: D006601:Hexoses; D037102:Lectins; D010429:Pentoses; D015922:Complement C1q; D004247:DNA