Effects of continuous and triggered atrial overdrive pacing on paroxysmal atrial fibrillation in pacemaker patients.
BACKGROUND
The aim of the study was to compare the effects of different pacing strategies to prevent paroxysmal atrial fibrillation (AF): triggered atrial overdrive pacing versus the combination of triggered and continuous overdrive pacing.


METHODS
Patients with an indication for dual-chamber pacing (Selection 9000, Prevent AF; Vitatron B.V., Arnhem, the Netherlands) and a history of paroxysmal AF were randomized to triggered atrial pacing (three pacing functions, "triggered group": PAC Suppression, Post-PAC Response, and Post-Exercise Response) or to the combination of continuous (Pace Conditioning) and triggered atrial pacing (four pacing functions, "combined group"). After 3 months, there was a crossover to the other pacemaker setting.


RESULTS
In 171 enrolled patients, the median AF burden of the combined group was with 2.1% versus 0.1% in the triggered group (P = 0.014). Fewer AF episodes were observed in the triggered (median: 7) than in the combined group (median: 116; P = 0.016). The combined group had more frequent atrial pacing (median 97%) than the triggered group with 85% (P < 0.001), but ventricular pacing was not significantly different with 95% and 96% in the combined and triggered group, respectively. After the crossover, the AF burden increased in the triggered group to 0.3% and decreased in the combined group to 0.4%.


CONCLUSIONS
Triggered atrial pacing functions alone resulted in a low AF burden. The additional activation of continuous atrial overdrive pacing increased the percentage of atrial pacing, but had no beneficial effects on the prevention of paroxysmal AF.
Schuchert
Andreas
A
Medical Clinic, Friedrich-Ebert Hospital, Neumünster, Germany. andreas.schuchert@fek.de
Rebeski
Hans-Peter
HP
Peiffer
Thomas
T
Bub
Eberhard
E
Dietz
Armin
A
Mortensen
Kai
K
Aydin
Mohammed Ali
MA
Camm
John
J
Gazarek
Steffen
S
Meinertz
Thomas
T
D000368:Aged; D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000517:prevention & control*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D010138:Pacemaker, Artificial / Q000706:statistics & numerical data*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors