G-Quadruplex formation interferes with P1 helix formation in the RNA component of telomerase hTERC.
Gros
Julien
J
INSERM, U565, Muséum National d'Histoire Naturelle (MNHN), USM 503-CNRS UMR 5153, "Acides Nucleiques: Dynamique, Ciblage et Fonctions Biologiques", 57 rue Cuvier, Case Postale 26, 75231 Paris cedex 05, France.
Guédin
Aurore
A
Mergny
Jean-Louis
JL
Lacroix
Laurent
L
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D054856:G-Quadruplexes; D006147:Guanine / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D009154:Mutation; D009690:Nucleic Acid Conformation / Q000187:drug effects; D009691:Nucleic Acid Denaturation; D009843:Oligoribonucleotides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011725:Pyridines / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D013379:Substrate Specificity; D019098:Telomerase / Q000737:chemistry* / Q000235:genetics*; D044366:Transition Temperature
C502660:2,6-N,N'-methyl-quinolinio-3-yl-pyridine dicarboxamide; D008024:Ligands; D009843:Oligoribonucleotides; D011725:Pyridines; D011804:Quinolines; D006147:Guanine; D012313:RNA; D019098:Telomerase