title: Anaerobic exercise reduces tumor growth, cancer cachexia and increases macrophage and lymphocyte response in Walker 256 tumor-bearing rats.
abstract: Here, we investigated the effect of jump exercise on tumor growth, cancer cachexia, lymphocyte proliferation and macrophage function in Walker 256 tumor-bearing rats. Male Wistar rats (60 days) were divided into sedentary (C) and exercised (E) groups. Jump training consisted of six sets of 10 jumps in water with overload of 50% of body mass with 1 min of resting, four times per week for 8 weeks. After 6 weeks of training, half of each group was inoculated with 2 x 10(7) cells of Walker 256 tumor. Sedentary tumor-bearing and exercised tumor-bearing are referred to as T and TE, respectively. Tumor weight in the T group was 25 g. These animals display loss of weight, hypertriacylglycerolemia, hyperlacticidemia, depletion of glycogen stores and increase in PIF expression. Jump exercise (TE) induced a significant lower tumor weight, preserves liver glycogen stores, partly prevented the hypertriacylglycerolemia, hyperlacticidemia and, prevented the fall in body weight and reduced PIF expression. Lymphocyte was increased by tumor burden (T) and was higher by including exercise (TE). The same was observed regarding phagocytosis and lysosomal volume. Anaerobic exercise decreases tumor growth, cancer cachexia and increases innate and adaptative immune function.
authors.affiliation: Department of Physiology, Biological Science Building, Federal University of Paraná, Curitiba, PR, Brazil.
authors.forename: Carina
authors.initials: C
authors.lastname: de Lima
authors.forename: Luciana E
authors.initials: LE
authors.lastname: Alves
authors.forename: Fabíola
authors.initials: F
authors.lastname: Iagher
authors.forename: Andressa Franzoi
authors.initials: AF
authors.lastname: Machado
authors.forename: Sandro J
authors.initials: SJ
authors.lastname: Bonatto
authors.forename: Diogo
authors.initials: D
authors.lastname: Kuczera
authors.forename: Carine Ferreira
authors.initials: CF
authors.lastname: de Souza
authors.forename: Daniele Cristina
authors.initials: DC
authors.lastname: Pequito
authors.forename: Ana Lúcia
authors.initials: AL
authors.lastname: Muritiba
authors.forename: Everson Araújo
authors.initials: EA
authors.lastname: Nunes
authors.forename: Luiz Cláudio
authors.initials: LC
authors.lastname: Fernandes
mesh_terms: D000818:Animals; D001835:Body Weight / Q000502:physiology; D002100:Cachexia / Q000503:physiopathology*; D002279:Carcinoma 256, Walker / Q000473:pathology* / Q000503:physiopathology*; D049109:Cell Proliferation; D004195:Disease Models, Animal; D006003:Glycogen / Q000378:metabolism; D007773:Lactates / Q000097:blood; D008214:Lymphocytes / Q000473:pathology / Q000502:physiology*; D008264:Macrophages / Q000473:pathology / Q000502:physiology*; D008297:Male; D010587:Phagocytosis / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism; D015431:Weight Loss / Q000502:physiology
chemical_list: D007773:Lactates; D014280:Triglycerides; D006003:Glycogen