Synthesis, antibacterial and antifungal activities of some N-nitroso-2,6-diarylpiperidin-4-one semicarbazones and QSAR analysis.
A series of N-nitroso-2,6-diarylpiperidin-4-one semicarbazones and thiosemicarbazones were synthesized, characterized by IR, NMR and elemental analysis. All the compounds were screened for their antibacterial activity against Gram-positive bacteria Bacillus subtilis, Staphylococcus aureus and Gram-negative bacteria Escherichia coli and fungi Candida albicans. These compounds have showed moderate and very good antibacterial activity. Quantitative Structure Activity Relationship (QSAR) analysis was performed for these compounds by the application of Semiempirical calculations and molecular modeling. Different logP values were also evaluated to further the analysis.
Hemalatha
T
T
Department of Chemistry, Annamalai University, Annamalainagar, Chidambram, Tamil Nadu 608002, India.
Imran
P K M
PK
Gnanamani
A
A
Nagarajan
S
S
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D016014:Linear Models; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D021281:Quantitative Structure-Activity Relationship; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D012664:Semicarbazones