Mechanical and biological properties of nanoporous carbon membranes.
Implantable blood glucose sensors have inadequate membrane-tissue interfaces for long term use. Biofouling and inflammation processes restrict biosensor membrane stability. An ideal biosensor membrane material must prevent protein adsorption and exhibit cell compatibility. In addition, a membrane must exhibit high porosity and low thickness in order to allow the biosensor to respond to analyte fluctuations. In this study, the structural, mechanical and biological properties of nanoporous alumina membranes coated with diamond-like carbon thin films were examined using scanning probe microscopy, nanoindentation and MTT viability assay. We anticipate that this novel membrane material could find use in immunoisolation devices, kidney dialysis membranes and other medical devices encountering biocompatibility issues that limit in vivo function.
Narayan
Roger J
RJ
Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599-7575, USA. roger narayan@unc.edu
Aggarwal
Ravi
R
Wei
Wei
W
Jin
Chunming
C
Monteiro-Riviere
Nancy A
NA
Crombez
Rene
R
Shen
Weidian
W
D002244:Carbon / Q000008:administration & dosage* / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004548:Elasticity; D006244:Hardness; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000187:drug effects*; D008422:Materials Testing; D008567:Membranes, Artificial; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D016062:Porosity; D013314:Stress, Mechanical; D013718:Tensile Strength
D008567:Membranes, Artificial; D002244:Carbon