Pestalachlorides A-C, antifungal metabolites from the plant endophytic fungus Pestalotiopsis adusta.
Pestalachlorides A-C (1-3), three new chlorinated benzophenone derivatives, have been isolated from cultures of an isolate of the plant endophytic fungus Pestalotiopsis adusta. The structures of these compounds were determined mainly by NMR spectroscopy, and the structures of 1 and 3 were further confirmed by X-ray crystallography. Pestalachloride A (1) was obtained as a mixture of two inseparable atropisomers (1a and 1b), whereas pestalachloride C (3) was found to be a racemic mixture. Compounds 1 and 2 displayed significant antifungal activities against three plant pathogens.
Li
Erwei
E
Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, No. 13 Beiyitiao, Zhongguancum, Beijing 100080, People's Republic of China.
Jiang
Lihua
L
Guo
Liangdong
L
Zhang
Hua
H
Che
Yongsheng
Y
D000840:Anisoles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001584:Benzoxepins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D005670:Fusarium / Q000187:drug effects*; D005874:Gibberella / Q000187:drug effects*; D007189:Indans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D054833:Isoindoles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D012015:Reference Standards; D012118:Resorcinols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013237:Stereoisomerism; D020172:Verticillium / Q000187:drug effects*
D000840:Anisoles; D000935:Antifungal Agents; D001572:Benzofurans; D001584:Benzoxepins; D007189:Indans; D054833:Isoindoles; D012118:Resorcinols; C532658:pestalachloride A; C532659:pestalachloride B; C532660:pestalachloride C