title: Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study).
abstract: We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7%). The independent factors which specified cardiovascular events were age (hazard ratio (HR)=1.13; 95% confidence interval (CI): 1.10-1.16; p<0.0001) and sex (HR=2.18; 95%CI: 1.23-3.85; p=0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR=1.11; 95%CI: 0.61-2.02; p=0.731).
authors.affiliation: Division of Cardiology, Department of Medicine, Kohka Public Hospital, Rokushin, Kohka-City, Shiga, Japan. shitamaki-circ@umin.ac.jp
authors.forename: Shinji
authors.initials: S
authors.lastname: Tamaki
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tabara
authors.forename: Tomonori
authors.initials: T
authors.lastname: Okamura
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kanda
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Kita
authors.forename: Takashi
authors.initials: T
authors.lastname: Kadowaki
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Tsujita
authors.forename: Tanvir
authors.initials: T
authors.lastname: Chowdhury Turin
authors.forename: Minoru
authors.initials: M
authors.lastname: Horie
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miki
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ueshima
mesh_terms: D044466:Asian People / Q000706:statistics & numerical data*; D002318:Cardiovascular Diseases / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*
chemical_list: C544065:AGTR1 protein, human; D044140:Receptor, Angiotensin, Type 1