Maxillary osteosarcoma associated with a dental implant: report of a case and review of the literature regarding implant-related sarcomas.
BACKGROUND
The development of malignant neoplasms has been reported as a rare complication of the use of implanted biomaterials. The majority of these cases have been sarcomas related to orthopedic hardware. The authors present the first reported case of a sarcoma arising in association with a dental implant.


METHODS
A 38-year-old woman developed a low-grade chondroblastic osteosarcoma of the right maxilla 11 months after receiving a titanium dental implant. She was treated with systemic chemotherapy and then a maxillary resection. As of this publication, 47 months later, she is alive and disease-free.


CONCLUSIONS
The use of endosseous implants has been associated with a low risk for the development of cancer. As the use of dental implants continues to expand, dentists need to be aware of this rare but devastating complication.
McGuff
H Stan
HS
Department of Pathology, Graduate School of Biomedical Sciences, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. mcguff@uthscsa.edu
Heim-Hall
Josefine
J
Holsinger
F Christopher
FC
Jones
Archie A
AA
O'Dell
Daniel S
DS
Hafemeister
Adam C
AC
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D019250:Dental Implants, Single-Tooth / Q000009:adverse effects*; D003764:Dental Materials / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008437:Maxilla / Q000601:surgery; D008441:Maxillary Neoplasms / Q000209:etiology* / Q000473:pathology; D020360:Neoadjuvant Therapy; D012516:Osteosarcoma / Q000209:etiology* / Q000473:pathology; D021362:Palate, Hard / Q000601:surgery; D014025:Titanium / Q000009:adverse effects
D003764:Dental Materials; D014025:Titanium