title: Skin problems associated with pegylated liposomal doxorubicin-more than palmoplantar erythrodysesthesia syndrome.
abstract: Liposomal pegylated doxorubicin is an encapsulation form of doxorubicin, with an improved pharmacokinetic profile and the ability to selectively accumulate into tumor tissue. As a result, the tolerated dose of the drug can be increased, followed by a reduced incidence of neutropenia and cardiotoxicity in comparison to doxorubucin treatment. However, a common adverse dose-schedule limiting effect of the treatment is palmoplantar erythrodysesthesia syndrome. In this retrospective study we included six patients hospitalised in the University Hospital of Zurich during the last 2 years, in connection with side effects caused by pegylated liposomal doxorubicin. These patients received this chemotherapeutic agent for treatment of various malignancies such as breast cancer, ovarian cancer, mycosis fungoides and cutaneous B-cell lymphoma. Three of six patients in this study developed classical palmoplantar erythrodysesthesia, one developed palmoplantar erythrodysesthesia associated with extensive bullous disease, one developed eruption of lymphocyte recovery syndrome and one developed intertrigo like dermatitis with stomatitis. Pegylated liposomal doxorubicin induces various skin reactions including palmoplantar erythrodysesthesia syndrome. However, the exact clinical presentation might depend on pre-existing skin diseases.
authors.affiliation: Department of Dermatology,University Hospital of Zurich, Gloriastrasse 31, Zurich, Switzerland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Mangana
authors.forename: Marie C
authors.initials: MC
authors.lastname: Zipser
authors.forename: Curdin
authors.initials: C
authors.lastname: Conrad
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Oberholzer
authors.forename: Antonio
authors.initials: A
authors.lastname: Cozzio
authors.forename: Alexander
authors.initials: A
authors.lastname: Knuth
authors.forename: Lars E
authors.initials: LE
authors.lastname: French
authors.forename: Reinhard
authors.initials: R
authors.lastname: Dummer
mesh_terms: D000328:Adult; D000368:Aged; D004317:Doxorubicin / Q000009:adverse effects / Q000031:analogs & derivatives*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D005533:Foot Dermatoses / Q000139:chemically induced*; D006229:Hand Dermatoses / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D010292:Paresthesia / Q000139:chemically induced*; D011092:Polyethylene Glycols / Q000009:adverse effects*; D012189:Retrospective Studies; D013577:Syndrome; D055815:Young Adult
chemical_list: C506643:liposomal doxorubicin; D011092:Polyethylene Glycols; D004317:Doxorubicin