A lufenuron pre-treatment may enhance the effects of enilconazole or griseofulvin in feline dermatophytosis?
The effectiveness of enilconazole (4 weekly rinses with a 0.2% solution) or griseofulvin (50mg/kg twice daily for 40 days) following a pre-treatment with oral lufenuron (100mg/kg by-weekly for 8 weeks) was tested on 25 (11+14) Microsporum canis infected cats. Control animals were treated with lufenuron, griseofulvin and enilconazole alone. At day 150 pre-treated animals were culturally negative and clinically cured. While lufenuron alone was found to be ineffective against M canis infection, an immunomodulatory effect of the drug can be suggested, as reported in literature. Its use could be reserved to long-lasting infections, unsuccessfully treated with conventional drugs. Further studies are required to clearly establish the possible adjuvant effect of this molecule when used prior to enilconazole or griseofulvin.
Mancianti
Francesca
F
Dipartimento di Patologia Animale, Profilassi ed Igiene degli Alimenti, University of Pisa, Viale delle Piagge 2, I 56124 Pisa, Italy. manciant@vet.unipi.it
Dabizzi
Sara
S
Nardoni
Simona
S
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use; D002371:Cat Diseases / Q000188:drug therapy* / Q000382:microbiology; D002415:Cats; D003881:Dermatomycoses / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D004359:Drug Therapy, Combination; D005260:Female; D005659:Fungicides, Industrial / Q000627:therapeutic use*; D006118:Griseofulvin / Q000627:therapeutic use; D007093:Imidazoles / Q000627:therapeutic use; D007306:Insecticides / Q000627:therapeutic use*; D008297:Male; D008864:Microsporum / Q000187:drug effects / Q000302:isolation & purification; D005466:Fluorocarbons
D000935:Antifungal Agents; D001549:Benzamides; D005659:Fungicides, Industrial; D006118:Griseofulvin; D007093:Imidazoles; D007306:Insecticides; C070364:fluphenacur; D005466:Fluorocarbons; C017435:enilconazole