Regulation of flagellar length in Chlamydomonas.
Chlamydomonas reinhardtii has two apically localized flagella that are maintained at an equal and appropriate length. Assembly and maintenance of flagella requires a microtubule-based transport system known as intraflagellar transport (IFT). During IFT, proteins destined for incorporation into or removal from a flagellum are carried along doublet microtubules via IFT particles. Regulation of IFT activity therefore is pivotal in determining the length of a flagellum. Reviewed is our current understanding of the role of IFT and signal transduction pathways in the regulation of flagellar length.
Wilson
Nedra F
NF
Department of Anatomy and Cell Biology, Oklahoma State University Center for Health Sciences, Tulsa, OK 74107, United States. nedra.wilson@okstate.edu
Iyer
Janaki Kannan
JK
Buchheim
Julie A
JA
Meek
William
W
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D016825:Chlamydomonas reinhardtii / Q000166:cytology* / Q000235:genetics; D005407:Flagella / Q000648:ultrastructure*; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism
D015800:Protozoan Proteins