title: [Incidence of seroresistance of syphilis and its relevant factors].
abstract: OBJECTIVE
  To investigate the incidence of seroresistance of syphilis and analyze its relevant factors.
  
  
  METHODS
  The clinical data of 131 patients with syphilis were retrospectively analyzed. The incidence of seroresistance was investigated and the correlation between seroresistance and factors including age, gender, original titer, disease course, and medications were analyzed.
  
  
  RESULTS
  The incidence of seroresistance was not significantly different among patients with different ages and genders, but was significantly different among patients with different disease courses, antibody titers, and medications. Patients with a baseline serum rapid plasma reagin (RPR) titer of greater than 1: 8, a latent course, or a macrolide therapy history had higher incidences of seroresistance (i. e., 61%, 45.6%, and 72.7% respectively) than those who had a lower RPR titer, a primary course, or a benzathine penicillin therapy history.
  
  
  CONCLUSIONS
  Syphilis patients with a high baseline RPR titer, a latent course, and a macrolides therapy are prone to be seroresistant.
authors.affiliation: Department of Dermatology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Lin-Na
authors.initials: LN
authors.lastname: Wang
authors.forename: Ya-Gang
authors.initials: YG
authors.lastname: Zuo
authors.forename: Yong-Xin
authors.initials: YX
authors.lastname: Liu
authors.forename: Xiu-Rong
authors.initials: XR
authors.lastname: Liu
authors.forename: He-Yi
authors.initials: HY
authors.lastname: Zheng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D018942:Macrolides / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011935:Reagins / Q000097:blood; D013587:Syphilis / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D013588:Syphilis Serodiagnosis / Q000379:methods; D055815:Young Adult
chemical_list: D018942:Macrolides; D011935:Reagins