[Insulin-like growth factor 1 (IGF-1) and growth hormone (hGH) as the markers of osteoarthritis].
OBJECTIVE
The aim of study was evaluation of diagnostic usefulness of IGF-1 and hGH serum level in osteoarthritis.


METHODS
IGF-1 and hGH concentration were measured in serum collected from 25 patients with coxarthrosis and 16 healthy persons. IGF-1 and hGH serum level were assayed by ELISA.


RESULTS
There was no statistics difference in growth hormone serum level between osteoarthritis patients and healthy persons. The ROC curve for hGH concentration confirmed low discriminatory value of this test. There was no significant correlation between hGH and IGF-1 in serum. IGF-1 concentration in patients serum was significant lower then in control grupe. The ROC curve for serum level of IGF-1 confirmed significant usefulness this test in laboratory diagnostic of osteoarthritis.


CONCLUSIONS
Serum concentration of IGF-1 seems to be usefull laboratory marker of osteoarthritis.
Lis
Kinga
K
Katedra i Zaklad Diagnostyki Laboratoryjnej Uniwersytet Mikołaja Kopernika w Toruniu Collegium Medicum w Bydgoszczy. kzlis@gazeta.pl
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000276:immunology*; D012372:ROC Curve
D015415:Biomarkers; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I