An enzyme kinetic model of blood island formation.
Blood islands are conglomerations of prevascular stem cells that form during vasculogenesis, a function critical to early vascular and hematopoietic development. In this paper, a model of blood island formation is proposed employing the approach of classical enzyme kinetics. Deterministic simulations of the model show the formation of blood island-like structures. These are compared to murine blood islands.
Matteson
Andrew
A
Department of Mathematics, Mailstop 3368, Texas A & M University, College Station, TX 77843-3368, USA. drew.matteson@gmail.com
D000818:Animals; D001808:Blood Vessels / Q000166:cytology / Q000196:embryology*; D053595:Embryonic Stem Cells / Q000166:cytology*; D004798:Enzymes / Q000378:metabolism; D050989:GATA2 Transcription Factor / Q000502:physiology; D006410:Hematopoiesis; D007700:Kinetics; D008433:Mathematics; D008648:Mesoderm / Q000166:cytology / Q000196:embryology; D051379:Mice; D008954:Models, Biological; D039904:Pluripotent Stem Cells / Q000166:cytology; D053773:Transforming Growth Factor beta1 / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D004798:Enzymes; D050989:GATA2 Transcription Factor; C494712:Gata2 protein, mouse; D053773:Transforming Growth Factor beta1; D042461:Vascular Endothelial Growth Factor A; C467480:vascular endothelial growth factor A, mouse