title: Impact of complete revascularization with percutaneous coronary intervention on survival in patients with at least one chronic total occlusion.
abstract: OBJECTIVE
  This study sought to determine the impact on survival of successful drug-eluting stent-supported percutaneous coronary intervention (PCI) for chronic total occlusion (CTO).
  
  
  RESULTS
  Comparison of long-term cardiac survival of consecutive patients who underwent PCI for at least one CTO and who were stratified into successful and failure procedures. From 2003 to 2006, 486 patients underwent PCI for 527 CTO. CTO-PCI was successful in 344 patients (71%) and 361 lesions (68%). Multivessel PCI was performed in 62% in the CTO-PCI failure group and in 71% in the CTO-PCI success group (P = 0.062). Cardiac survival rate was higher in the CTO-PCI success group compared with CTO-PCI failure group (91.6 +/- 2.0 vs. 87.4 +/- 2.9%; P = 0.025), in patients with multivessel disease and CTO-PCI success compared with CTO-PCI failure (91.4 +/- 2.2 vs. 86.6 +/- 3.1%; P = 0.021), and in patients with complete revascularization when compared to patients with incomplete revascularization (94.0 +/- 1.7 vs. 83.8 +/- 3.6%; P < 0.001).
  
  
  CONCLUSIONS
  Successful CTO-PCI confers a long-term survival benefit. Improvement in survival is driven by the differences in the outcome of patients with multivessel disease and who were completely revascularized.
authors.affiliation: Division of Cardiology, Careggi Hospital, Viale Pieraccini, I-50134 Florence, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Valenti
authors.forename: Angela
authors.initials: A
authors.lastname: Migliorini
authors.forename: Umberto
authors.initials: U
authors.lastname: Signorini
authors.forename: Ruben
authors.initials: R
authors.lastname: Vergara
authors.forename: Guido
authors.initials: G
authors.lastname: Parodi
authors.forename: Nazario
authors.initials: N
authors.lastname: Carrabba
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Cerisano
authors.forename: David
authors.initials: D
authors.lastname: Antoniucci
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods* / Q000401:mortality; D002908:Chronic Disease; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000401:mortality / Q000628:therapy*; D054059:Coronary Occlusion / Q000401:mortality / Q000628:therapy*; D054855:Drug-Eluting Stents; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects