Sequential effects of daily arsenic trioxide treatment on essential and nonessential trace elements in tissues in mice.
Despite arsenic's (As) toxic potential, arsenic trioxide (As2O3) is used as a safe and effective treatment in acute promyelocytic leukaemia. However, it is unknown whether such therapy influences the balance of other trace elements in the body. In this study, mice were treated intraperitoneally daily with 1.0 mg As2O3/kg bw for 3, 5 or 7 days. As, and seven essential and nonessential trace elements with the potential to interact with As, were measured through inductively coupled plasma-mass spectrometry in serum, heart, lung, liver, pancreas, kidney, intestine and brain. As2O3 supplementation increased As in all target tissues on day 3, thereafter reaching an almost steady state. The major findings in other elements were a sequential decrease in serum zinc (on day 7 by 64%; P<0.001), and a decrease in selenium in the pancreas on day 3 (9%; P<0.05), in the intestine on day 3 (30%; P<0.001) and finally, in the brain on days 5 (12%; P<0.05) and 7 (15%; P<0.01). Changes in magnesium, iron, copper, cadmium and mercury were minor and inconsistent. This study suggests that supplementation with other trace elements may be beneficial when As2O3 treatment regimens are used in the clinic.
Molin
Ylva
Y
Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden. ylva.molin@medsci.uu.se
Frisk
Peter
P
Ilbäck
Nils-Gunnar
NG
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000494:pharmacology*; D005504:Food Analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D010087:Oxides / Q000494:pharmacology*; D014018:Tissue Distribution; D014131:Trace Elements / Q000378:metabolism*; D014881:Water Supply / Q000032:analysis
D000970:Antineoplastic Agents; D001152:Arsenicals; D010087:Oxides; D014131:Trace Elements; D000077237:Arsenic Trioxide