[A comparative analysis of distribution of glyprolines administered by various routes].
The distribution of the glyprolines Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selanc) was analyzed and compared in tissues of rat organs after different ways of their administration using the peptides uniformly labeled with tritium. Comparative data on changes in concentrations of the peptides in the rat organs after their intraperitoneal, intranasal, intragastric, and intravenous administration are given. The intranasal administration of both peptides was shown to be optimal for the delivery of glyproline molecules in the CNS. A high affinity of the studied glyprolines for gastric tissues was found for all the ways of their administration. We suggest that a high efficiency of action of glyprolines on homeostasis of the gastric mucous tunic was partially provided by accumulation of these peptides (to high concentrations) in gastric tissues.
Ashmarin
I P
IP
Baglikova
K E
KE
Edeeva
S E
SE
Zolotarev
Iu A
IuA
Kozik
V S
VS
Dadaian
A K
AK
Dorokhova
E M
EM
Alfeeva
L Iu
LIu
Andreeva
L A
LA
Kopylova
G N
GN
Pavlov
T S
TS
Vas'kovskiĭ
B V
BV
Meshavkin
V K
VK
Sokolov
O Iu
OIu
Kost
N V
NV
Zozulia
A A
AA
Samonina
G E
GE
Miasoedov
N F
NF
D000818:Animals; D004333:Drug Administration Routes; D005753:Gastric Mucosa / Q000378:metabolism; D009842:Oligopeptides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011392:Proline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D051381:Rats; D014018:Tissue Distribution
D009842:Oligopeptides; C113164:prolyl-glycyl-proline; D011392:Proline; C100827:TP 7