Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials.
An efficient synthesis of two new N-acetyl-4'-arylphenylalanines is described together with their incorporation into a number of cationic peptoid antibacterial agents, one of which had an MIC of 7.8 microg/mL against Staphylococcus aureus.
Boyle
Timothy P
TP
School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
Bremner
John B
JB
Coates
Jonathan A
JA
Deadman
John
J
Keller
Paul A
PA
Pyne
Stephen G
SG
Somphol
Kittiya
K
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010649:Phenylalanine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D010649:Phenylalanine