title: The unresolved issues with risk stratification and management of patients with coronary artery disease undergoing major vascular surgery.
abstract: OBJECTIVE
  The purpose of this article, with a specific focus on patients undergoing vascular surgery, is to review controversial issues related to mechanisms of perioperative myocardial infarction (MI), coronary artery disease detection, and strategies to reduce perioperative complications. We propose explanations for the many conflicting results that have recently emerged in the literature.Source documents: We searched MEDLINE and reviewed all relevant manuscripts and scientific statements regarding management of patients undergoing non-cardiac surgery.
  
  
  RESULTS
  Identification and prevention of ischemia in patients undergoing vascular surgery remains controversial. While the identification of preoperative ischemia is a marker of a higher perioperative risk, the value of identifying such ischemia has been questioned. We believe this may be, at least in part, due to our limited understanding of perioperative MI. Appropriate management of patients, based on the results of such testing, is likely the key to improving outcomes, and deserves further investigation. Efforts aimed at reducing the ischemic consequences of severe coronary plaques (by revascularization or beta-blocker therapy) have yielded conflicting results. The use of high doses of preoperative beta-blocker therapy may be harmful. Some studies suggest a promising role for statin therapy. Benefits of acetylsalicylic acid must be weighted against the risk of bleeding.
  
  
  CONCLUSIONS
  Many questions remain unanswered about the impact of detecting inducible ischemia, and the role of revascularization or beta-blockers in patients undergoing vascular surgery. A better understanding of the pathophysiology of perioperative MI is critical, in order to identify the best approach to improve cardiac outcomes in these patients.
authors.affiliation: Division of Cardiology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), 3850 Saint-Urbain, Montreal, Quebec H2W 1T7, Canada.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Parent
authors.forename: Stéphane
authors.initials: S
authors.lastname: Rinfret
mesh_terms: D003324:Coronary Artery Disease / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D016343:Monitoring, Intraoperative / Q000379:methods; D017202:Myocardial Ischemia / Q000517:prevention & control*; D019990:Perioperative Care / Q000379:methods; D018570:Risk Assessment; D014656:Vascular Surgical Procedures / Q000009:adverse effects*