title: Circulating CD34-positive cells have prognostic value for neurologic function in patients with past cerebral infarction.
abstract: Increasing evidence points to a role for circulating endothelial progenitors, including populations of CD34-positive (CD34(+)) cells present in peripheral blood, in vascular homeostasis and neovascularization. In this report, circulating CD34(+) cells in individuals with a history of cerebral infarction were correlated with changes in neurologic function over a period of 1 year. Patients with decreased levels of CD34(+) cells displayed significant worsening in neurologic function, evaluated by the Barthel Index and Clinical Dementia Rating. These results support the hypothesis that levels of circulating CD34(+) cells have prognostic value for neural function, consistent with their potential role in maintaining cerebral circulation.
authors.affiliation: Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan. taguchi@ri.ncvc.go.jp
authors.forename: Akihiko
authors.initials: A
authors.lastname: Taguchi
authors.forename: Nami
authors.initials: N
authors.lastname: Nakagomi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Akie
authors.initials: A
authors.lastname: Kikuchi-Taura
authors.forename: Hiroo
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kasahara
authors.forename: Haruka
authors.initials: H
authors.lastname: Hirose
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Moriwaki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakagomi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Soma
authors.forename: David M
authors.initials: DM
authors.lastname: Stern
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Naritomi
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism*; D002465:Cell Movement; D002490:Central Nervous System / Q000166:cytology* / Q000378:metabolism*; D002544:Cerebral Infarction / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011379:Prognosis
chemical_list: D018952:Antigens, CD34