title: Cyclin and protamine as prognostic molecular marker for testicular sperm extraction in patients with azoospermia.
abstract: The CCNA1, CCNB1, CCNB2, PRM1, and PRM2 messenger RNA transcript ratios were significantly decreased in patients with spermatogenic disorders. These messenger RNA transcript ratios in patients with successful sperm retrieval were higher than in patients with failed sperm retrieval.
authors.affiliation: Department of Organs Therapeutics, Division of Urology, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Haraguchi
authors.forename: Tomomoto
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Kohei
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Masato
authors.initials: M
authors.lastname: Fujisawa
mesh_terms: D053713:Azoospermia / Q000175:diagnosis / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D019925:Cyclin A / Q000378:metabolism; D056750:Cyclin A1; D019926:Cyclin B / Q000378:metabolism; D056744:Cyclin B1; D056765:Cyclin B2; D016213:Cyclins / Q000378:metabolism*; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000378:metabolism; D008297:Male; D011379:Prognosis; D011479:Protamines / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D053625:Sperm Retrieval; D013737:Testis / Q000473:pathology
chemical_list: D015415:Biomarkers; C503745:CCNA1 protein, human; C534699:CCNB1 protein, human; C503758:CCNB2 protein, human; D019925:Cyclin A; D056750:Cyclin A1; D019926:Cyclin B; D056744:Cyclin B1; D056765:Cyclin B2; D016213:Cyclins; C082073:PRM1 protein, human; D011479:Protamines; D012333:RNA, Messenger; C068621:protamine 2