title: Cost effectiveness of chest pain unit care in the NHS.
abstract: BACKGROUND
  Acute chest pain is responsible for approximately 700,000 patient attendances per year at emergency departments in England and Wales. A single centre study of selected patients suggested that chest pain unit (CPU) care could be less costly and more effective than routine care for these patients, although a more recent multi-centre study cast doubt on the generalisability of these findings.
  
  
  METHODS
  Our economic evaluation involved modelling data from the ESCAPE multi-centre trial along with data from other sources to estimate the comparative costs and effects of CPU versus routine care. Cost effectiveness ratios (cost per QALY) were generated from our model.
  
  
  RESULTS
  We found that CPU compared to routine care resulted in a non-significant increase in effectiveness of 0.0075 QALYs per patient and a non-significant cost decrease of 32 pounds sterling per patient and thus a negative incremental cost effectiveness ratio. If we are willing to pay 20,000 pounds sterling for an additional QALY then there is a 70% probability that CPU care will be considered cost-effective.
  
  
  CONCLUSIONS
  Our analysis shows that CPU care is likely to be slightly more effective and less expensive than routine care, however, these estimates are surrounded by a substantial amount of uncertainty. We cannot reliably conclude that establishing CPU care will represent a cost-effective use of health service resources given the substantial amount of investment it would require.
authors.affiliation: Health Economics and Decision Science (HEDS), School of health and related research, University of Sheffield, 30 Regent Street,Sheffield, UK. y.oluboyede@leeds.ac.uk
authors.forename: Yemi
authors.initials: Y
authors.lastname: Oluboyede
authors.forename: Steve
authors.initials: S
authors.lastname: Goodacre
authors.forename: Allan
authors.initials: A
authors.lastname: Wailoo
mesh_terms: D002637:Chest Pain / Q000191:economics* / Q000628:therapy; D003362:Cost-Benefit Analysis; D003663:Decision Trees; D003955:Diagnostic Tests, Routine / Q000191:economics; D004636:Emergency Service, Hospital / Q000191:economics* / Q000458:organization & administration; D017048:Health Care Costs; D006757:Hospital Units / Q000191:economics*; D006801:Humans; D018803:Models, Economic; D009203:Myocardial Infarction / Q000191:economics / Q000628:therapy*; D017064:Process Assessment, Health Care; D011785:Quality Assurance, Health Care; D019057:Quality-Adjusted Life Years; D013222:State Medicine / Q000191:economics*; D006113:United Kingdom