title: Identification of loci associated with schizophrenia by genome-wide association and follow-up.
abstract: We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).
authors.affiliation: Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK. wpcmod@cf.ac.uk
authors.forename: Michael C
authors.initials: MC
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authors.lastname: Duan
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authors.lastname: Sanders
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authors.lastname: Levinson
authors.forename: Pablo V
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authors.lastname: Gejman
authors.forename: Sven
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authors.lastname: Cichon
authors.forename: Markus M
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authors.lastname: Nöthen
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authors.lastname: Corvin
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authors.lastname: Kirov
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authors.forename: Nancy G
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authors.lastname: Buccola
authors.forename: Bryan J
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authors.lastname: Mowry
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authors.lastname: Freedman
authors.forename: Farooq
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authors.lastname: Amin
authors.forename: Donald W
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authors.lastname: Black
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authors.lastname: Silverman
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mesh_terms: D001714:Bipolar Disorder / Q000235:genetics; D016022:Case-Control Studies; D002874:Chromosome Mapping; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D051741:Kruppel-Like Transcription Factors; C540527:ZNF804A protein, human