Trends in lung cancer incidence by histological type in Osaka, Japan.
BACKGROUND
In Japan, an increase in age-adjusted incidence rates of lung adenocarcinoma (ADC) and a decrease in lung squamous cell carcinoma (SQCC) have been reported.


METHODS
The number of lung cancer incidence, age-adjusted rates, and age-specific rates by birth-cohort according to histological type were examined using the data from Osaka Cancer Registry.


RESULTS
The numbers of lung cancer incidence among men and women have increased, particularly in ADC. The age-adjusted incidence rates of ADC among men and women have continuously increased, while those of SQCC and small cell carcinoma (SMCC) turned to decrease since 1990s. A trough of lung cancer incidence rates was observed among men in 1935-39 birth-cohorts. The declining trend appeared in 1955-59 birth-cohorts. Lung cancer incidence rates among women have increased since 1895-99 birth-cohorts, but those rates leveled off or decreased in 1950s birth-cohorts. Trends of ADC by birth-cohort were almost the same as those of all histological types. The SQCC among men peaked in 1915-19 birth-cohorts, and decreased in the subsequent birth-cohorts. The SMCC among men peaked in 1920s birth-cohorts, and decreased or leveled off in the subsequent birth-cohorts.


CONCLUSIONS
Lung cancer incidence rates by birth-cohorts were almost parallel to the smoking prevalence. However, those for ADC among young women in 1950s birth-cohorts were not parallel to the smoking prevalence, which requires careful monitoring to confirm such findings.
Toyoda
Yasuhiro
Y
Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Disease, Higashinari-ku, Osaka 537-8511, Japan.
Nakayama
Tomio
T
Ioka
Akiko
A
Tsukuma
Hideaki
H
D000230:Adenocarcinoma / Q000453:epidemiology* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018288:Carcinoma, Small Cell / Q000453:epidemiology* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012907:Smoking; D013997:Time Factors