title: Highly purified HMG versus recombinant FSH for ovarian stimulation in IVF cycles.
abstract: The objective of this study was to compare the live birth rates resulting from ovarian stimulation with highly purified human menopausal gonadotrophin (HP-HMG), which combines FSH and human chorionic gonadotrophin-driven LH activities, or recombinant FSH (rFSH) alone in women undergoing IVF cycles. An integrated analysis was performed of the raw data from two randomized controlled trials that were highly comparable in terms of eligibility criteria and post-randomization treatment regimens with either HP-HMG or rFSH for ovarian stimulation in IVF, following a long down-regulation protocol. All randomized subjects who received at least one dose of gonadotrophin in an IVF cycle (HP-HMG, n = 491; rFSH, n = 495) were included in the analysis. Subjects who underwent intracytoplasmic sperm injection cycles were excluded. The superiority of one gonadotrophin preparation over the other was tested using the likelihood ratio test in a logistic regression analysis. The live birth rate per cycle initiated was 26.5% (130/491) with HP-HMG and 20.8% (103/495) with rFSH (P = 0.041). The odds ratio in favour of HP-HMG was 1.36 (95% confidence interval: 1.01-1.83). Thus, the findings of this integrated analysis demonstrate that ovarian stimulation with HP-HMG, following a long down-regulation protocol, in IVF cycles results in significantly more live births than stimulation with rFSH alone.
authors.affiliation: Centre for Reproductive Medicine, Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium. peterplatteau@telenet.be
authors.forename: Peter
authors.initials: P
authors.lastname: Platteau
authors.forename: Anders
authors.initials: A
authors.lastname: Nyboe Andersen
authors.forename: Anne
authors.initials: A
authors.lastname: Loft
authors.forename: Johan
authors.initials: J
authors.lastname: Smitz
authors.forename: Pascal
authors.initials: P
authors.lastname: Danglas
authors.forename: Paul
authors.initials: P
authors.lastname: Devroey
mesh_terms: D000293:Adolescent; D000328:Adult; D010064:Embryo Implantation; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008596:Menotropins / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D016032:Randomized Controlled Trials as Topic; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D008596:Menotropins; D005640:Follicle Stimulating Hormone