title: An ungracious host for an unwelcome guest.
abstract: Persistence of latently infected CD4(+) T cell "reservoirs" presents a major obstacle for current HIV-1 antiretroviral therapies. In Cell Host & Microbe, two separate studies use model systems of latent infection to dissect the influence of host genes on HIV-1 transcription, yielding intriguing, though partially contradictory, conclusions.
authors.affiliation: Sir William Dunn School of Pathology, South Parks Road, University of Oxford OX1 3RE, UK. kelly.perkins@path.ox.ac.uk
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Perkins
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Proudfoot
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D015658:HIV Infections / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D014158:Transcription, Genetic; D017735:Virus Latency