N-methyl-D-aspartate receptors and amnesia in mice with depression-like state.
We studied the effect of activation (N-methyl-D-aspartic acid and D-cycloserine) and blockade (dizocilpine and 7-chlorokynurenic acid) of N-methyl-D-aspartate receptors on the development of amnesia in intact and depressive mice under conditions of conditioned passive avoidance response. Agonists and antagonists of N-methyl-D-aspartate receptors produce a strong antiamnesic effect in mice with behavioral despair. In intact animals, only N-methyl-D-aspartic acid and D-cycloserine improved passive avoidance performance.
Dubrovina
N I
NI
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. dubrov@iph.ma.nsc.ru
Zinovyev
D R
DR
Zinovyeva
D V
DV
D000647:Amnesia / Q000150:complications / Q000503:physiopathology* / Q000517:prevention & control; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D003523:Cycloserine / Q000494:pharmacology; D003863:Depression / Q000209:etiology / Q000503:physiopathology*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D007736:Kynurenic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016202:N-Methylaspartate / Q000494:pharmacology; D017459:Receptors, Amino Acid / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*
D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D017459:Receptors, Amino Acid; C031959:aspartic acid receptor; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; D003523:Cycloserine; D007736:Kynurenic Acid; C057013:7-chlorokynurenic acid