title: A comparative study to screen dementia and APOE genotypes in an ageing East African population.
abstract: Previous studies have established cross-cultural methods to screen for ageing- related dementia and susceptibility genes, in particular Alzheimer's disease (AD) among the Canadian Cree, African Americans and Yoruba in Nigeria. We determined whether the Community Screening Interview for Dementia (CSID), translated into Kikuyu, a major language of Kenya, could be used to evaluate dementia of the Alzheimer type. Using two sets of coefficients of cognitive and informant scores, two discriminant function (DF) scores were calculated for each of 100 elderly (>65 years) Nyeri Kenyans. When the cut-off points were selected for 100% sensitivities, the specificities of the DF scores were remarkably similar (93.75%) in the Kenyan sample. We propose the adapted CSID can be utilised to detect dementia among East Africans. We also show that apolipoprotein E epsilon 4 allele frequencies were high (approximately 30%) and not different between normal subjects and those with probable AD. There was no evidence to suggest years of education or vascular factors were associated with dementia status.
authors.affiliation: Laboratory of Neurogeriatrics, Department of Neurology and Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Chien-Hsiun
authors.initials: CH
authors.lastname: Chen
authors.forename: Toshiki
authors.initials: T
authors.lastname: Mizuno
authors.forename: Robert
authors.initials: R
authors.lastname: Elston
authors.forename: Monica M
authors.initials: MM
authors.lastname: Kariuki
authors.forename: Kathleen
authors.initials: K
authors.lastname: Hall
authors.forename: Fred
authors.initials: F
authors.lastname: Unverzagt
authors.forename: Hugh
authors.initials: H
authors.lastname: Hendrie
authors.forename: Samuel
authors.initials: S
authors.lastname: Gatere
authors.forename: Paul
authors.initials: P
authors.lastname: Kioy
authors.forename: Nilesh B
authors.initials: NB
authors.lastname: Patel
authors.forename: Robert P
authors.initials: RP
authors.lastname: Friedland
authors.forename: Raj N
authors.initials: RN
authors.lastname: Kalaria
mesh_terms: D000351:Africa, Eastern; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D000483:Alleles; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D044383:Black People / Q000235:genetics; D003704:Dementia / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D005828:Genetics, Population; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010865:Pilot Projects; D018709:Statistics, Nonparametric; D001741:Black or African American
chemical_list: D001057:Apolipoproteins E