title: [Study on biocompatibility of hydroxyapatite/high density polyethylene (HA/HDPE) nano-composites artificial ossicle].
abstract: This study was aimed to evaluate the biocompatibility of Hydroxyapatite/High density polyethylene (HA/ HDPE) nano-composites artificial ossicle. The percentage of S-period cells were detected by flow cytometry after L929 cells being incubated with extraction of the HA/HDPE nano-composites; the titanium materials for clinical application served as the contrast. In addition, both materials were implanted in animals and the histopathological evaluations were conducted. There were no statistically significant differences between the two groups (P >0.05). The results demonstrated that the HA/HDPE nano-composite artificial ossicle made by our laboratory is of a good biocompatibility and clinical application outlook.
authors.affiliation: Transplantation Medical Academy, Third XiangYa Hospital, Central South University, Changsha 410013, China.
authors.forename: Guohui
authors.initials: G
authors.lastname: Wang
authors.forename: Shaihong
authors.initials: S
authors.lastname: Zhu
authors.forename: Guolin
authors.initials: G
authors.lastname: Tan
authors.forename: Kechao
authors.initials: K
authors.lastname: Zhou
authors.forename: Suping
authors.initials: S
authors.lastname: Huang
authors.forename: Yanzhong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Zhiyou
authors.initials: Z
authors.lastname: Li
authors.forename: Boyun
authors.initials: B
authors.lastname: Huang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D004429:Ear Ossicles; D005260:Female; D020007:Implants, Experimental; D008297:Male; D008422:Materials Testing; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry; D020959:Polyethylene / Q000737:chemistry*; D013552:Swine
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D020959:Polyethylene; D017886:Durapatite