WHAMMing into the Golgi.
A new paper from Campellone et al. in a recent issue of Cell identifies WHAMM, a multifunctional protein that stimulates Arp2/3-mediated actin polymerization, binds and organizes microtubules, and influences the structure and efficiency of the Golgi complex. WHAMM's membrane localization at the entry face of the Golgi complex is novel for an actin nucleation-promoting factor, and highlights the importance of the cytoskeleton in organizing the secretory pathway.
Hayes
Garret L
GL
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307, USA.
Pfeffer
Suzanne R
SR
D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism; D000199:Actins / Q000378:metabolism*; D000818:Animals; D006056:Golgi Apparatus / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*
D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D011506:Proteins