title: Transplantation of olfactory mucosa following spinal cord injury promotes recovery in rats.
abstract: Several recent studies have demonstrated the potential therapeutic role of olfactory ensheathing cells in spinal cord injury. The aim of this study was to elucidate whether grafts of nasal olfactory mucosa containing olfactory ensheathing cells can repair the injured rat spinal cord as compared with the nasal respiratory mucosa containing no olfactory ensheathing cells. These grafts were then transplanted into the partially removed rat spinal cord. Compared with the respiratory mucosa-transplanted rats, the olfactory mucosa-transplanted rats partially recovered the movement of their hindlimbs and joints. Corticospinal tracing indicated that olfactory mucosa transplantation restored the severed tract. Therefore, olfactory mucosa has potential value in the repair of spinal cord injury.
authors.affiliation: aDepartment of Neurosurgery, Osaka University Medical School, Suita, Osaka, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Iwatsuki
authors.forename: Toshiki
authors.initials: T
authors.lastname: Yoshimine
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Kishima
authors.forename: Masanori
authors.initials: M
authors.lastname: Aoki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ishihara
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ohnishi
authors.forename: Carlos
authors.initials: C
authors.lastname: Lima
mesh_terms: D000818:Animals; D005260:Female; D006614:Hindlimb / Q000294:innervation / Q000502:physiology; D009043:Motor Activity / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology; D009831:Olfactory Mucosa / Q000637:transplantation*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000502:physiology*; D020545:Respiratory Mucosa / Q000637:transplantation*; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000601:surgery*; D016378:Tissue Transplantation / Q000379:methods; D014182:Transplantation, Autologous; D016896:Treatment Outcome