Diagnosis and treatment of congenital hemophilia with inhibitors a Latin American perspective.
The Committee of Latin America on the Therapeutics of Inhibitor Groups (CLOTTING) is composed of a number of hemophilia specialists from Latin America. The group aims to encourage the adoption of a good standard of care for Latin American patients with hemophilia. The occurrence of inhibitors in patients with hemophilia poses clinical challenges, and it is estimated that between 1000 and 3000 patients in Latin America are affected by hemophilia with inhibitors. There is an urgent need to establish a regional consensus and clinical guidelines for the diagnosis and treatment of these patients. We present an extensive review based on best current clinical practice and published literature, as seen from a Latin American perspective, taking into account the variable nature of hemophilia care available in the various countries in this Region.
Pérez Bianco
Raúl
R
lnstituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Fundación Nacional de Hemofilia, Buenos Aires, Argentina. perezbianco@hematologia.anm.edu.ar
Ozelo
Margareth Castro
MC
Villaça
Paula Ribeiro
PR
Solano
Maria Helena
MH
Jimenez Cruze
Guillermo
G
Martinez Murillo
Carlos
C
Garcia Chavez
Jaime
J
Mendoza
Saul
S
Rodriguez Grecco
Ismael
I
Ruiz-Saez
Arlette
A
D000328:Adult; D001779:Blood Coagulation Factors / Q000008:administration & dosage; D002648:Child; D003029:Coagulants / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005164:Factor IX / Q000008:administration & dosage*; D005169:Factor VIII / Q000008:administration & dosage*; D006467:Hemophilia A / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy*; D002836:Hemophilia B / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007843:Latin America; D017410:Practice Guidelines as Topic; D012720:Severity of Illness Index
D001779:Blood Coagulation Factors; D003029:Coagulants; C025667:prothrombin complex concentrates; D005169:Factor VIII; D005164:Factor IX; C065655:anti-inhibitor coagulant complex