title: Inhibition of thioredoxin reductase by curcumin analogs.
abstract: Curcumin analogs were first investigated for their inhibitory effects on thioredoxin reductase (TrxR). Most of them were more potent TrxR inhibitors than natural curcumin. The structure-activity relationship was summarized, and the curcumin analog was found to inhibit TrxR irreversibly in a time-dependent manner. The action was caused by covalent modification of the redox-active residues Cys(497) and Sec(498) in TrxR.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Liu
authors.forename: Zhi-Yun
authors.initials: ZY
authors.lastname: Du
authors.forename: Zhi-Shu
authors.initials: ZS
authors.lastname: Huang
authors.forename: Kin-Sing
authors.initials: KS
authors.lastname: Lee
authors.forename: Lian-Quan
authors.initials: LQ
authors.lastname: Gu
mesh_terms: D003474:Curcumin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D013880:Thioredoxin-Disulfide Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D013880:Thioredoxin-Disulfide Reductase; D003474:Curcumin