title: Basal metabolic rate is decreased in women with polycystic ovary syndrome and biochemical hyperandrogenemia and is associated with insulin resistance.
abstract: OBJECTIVE
  To evaluate basal metabolic rate (BMR) in women with PCOS and to determine its association with insulin resistance (IR).
  
  
  METHODS
  Prospective assessment of BMR in women with PCOS.
  
  
  METHODS
  Outpatient clinic of the Division of Reproductive Endocrinology.
  
  
  METHODS
  The study included 91 Greek women with PCOS and biochemical hyperandrogenemia, with mean age 24.03 +/- 0.55 years and mean body mass index (BMI) 26.67 +/- 0.69 kg/m(2), and 48 matched regularly menstruating women, with mean age 26.33 +/- 0.93 years and mean BMI 23.35 +/- 0.85 kg/m(2), as control subjects.
  
  
  METHODS
  Assessment of BMR by indirect calorimetry, IR by HOMA and QUICKI indices, fasting insulin, and fasting glucose/insulin ratio.
  
  
  METHODS
  Reduced BMR in PCOS with or without IR.
  
  
  RESULTS
  Adjusted BMR was 1,868 +/- 41 kcal/day in the control group, 1,445.57 +/- 76 in all PCOS women, 1,590 +/- 130 in PCOS women without IR and 1,116 +/- 106 in PCOS women with IR. Adjusted BMR showed a statistically significant difference between women with PCOS and control subjects, with lowest values in the group of PCOS women with IR, even after adjusting all groups for age and BMI.
  
  
  CONCLUSIONS
  Women with PCOS, particularly those with IR, present a significantly decreased BMR.
authors.affiliation: Division of Reproductive Endocrinology, University of Patras Medical School, University Hospital, Patras, Greece. neoklisg@hol.gr
authors.forename: Neoklis A
authors.initials: NA
authors.lastname: Georgopoulos
authors.forename: Alexandros D
authors.initials: AD
authors.lastname: Saltamavros
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Vervita
authors.forename: Kyriakos
authors.initials: K
authors.lastname: Karkoulias
authors.forename: George
authors.initials: G
authors.lastname: Adonakis
authors.forename: George
authors.initials: G
authors.lastname: Decavalas
authors.forename: George
authors.initials: G
authors.lastname: Kourounis
authors.forename: Kostas B
authors.initials: KB
authors.lastname: Markou
authors.forename: Venetsana
authors.initials: V
authors.lastname: Kyriazopoulou
mesh_terms: D000328:Adult; D001481:Basal Metabolism / Q000502:physiology*; D001823:Body Composition; D005260:Female; D006115:Greece; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications / Q000503:physiopathology*; D007333:Insulin Resistance / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D011446:Prospective Studies; D012016:Reference Values; D055815:Young Adult