title: The actin propulsive machinery: the proteome of Listeria monocytogenes tails.
abstract: Actin-based comet tails produced by Listeria monocytogenes are considered as representative models for cellular force-producing machineries crucial for cell migration. We here present a proteomic picture of these tails formed in extracts from brain and platelets. This provides a comprehensive view, revealing high molecular complexity and novel host cell proteins as tail components, and suggests the participation of specific multicomponent regulatory complexes. This work forms a new basis to expand current models of cellular protrusion.
authors.affiliation: Department of Medical Protein Research, VIB, B-9000 Ghent, Belgium.
authors.forename: Marleen
authors.initials: M
authors.lastname: Van Troys
authors.forename: Anja
authors.initials: A
authors.lastname: Lambrechts
authors.forename: Violaine
authors.initials: V
authors.lastname: David
authors.forename: Hans
authors.initials: H
authors.lastname: Demol
authors.forename: Magda
authors.initials: M
authors.lastname: Puype
authors.forename: Javier
authors.initials: J
authors.lastname: Pizarro-Cerda
authors.forename: Kris
authors.initials: K
authors.lastname: Gevaert
authors.forename: Pascale
authors.initials: P
authors.lastname: Cossart
authors.forename: Joël
authors.initials: J
authors.lastname: Vandekerckhove
mesh_terms: D000199:Actins / Q000378:metabolism*; D001792:Blood Platelets / Q000382:microbiology; D001921:Brain / Q000382:microbiology; D002148:Calmodulin-Binding Proteins / Q000378:metabolism; D002465:Cell Movement; D006367:HeLa Cells; D006801:Humans; D008089:Listeria monocytogenes / Q000502:physiology*; D008088:Listeriosis / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism; D020543:Proteome
chemical_list: D000199:Actins; D002148:Calmodulin-Binding Proteins; D009479:Neuropeptides; D020543:Proteome; C053386:drebrins