title: Neurally induced umbilical cord blood cells modestly repair injured spinal cords.
abstract: Umbilical cord blood (UCB) is known to have stem/progenitor cells. We earlier showed that novel progenitors could be isolated from cryopreserved human UCB with high efficiency. The multipotent progenitor cells were induced to differentiate into neural-lineage cells under the appropriate condition. In this study, we confirmed these neurally induced progenitor cells (NPCs), containing higher quantities of nerve growth factor, promoted functional recovery in rats with spinal cord injury (SCI). Sprague-Dawley rats with SCI achieved a modest improvement in locomotor rating scale until 10 weeks after transplantation of the NPCs. SCI rats treated with NPCs also showed somatosensory-evoked potentials were recovered, and grafted cells especially exhibited oligodendrocytic phenotype around the necrotic cavity. These findings suggest that UCB-NPCs might be a therapeutic resource to repair damaged spinal cords.
authors.affiliation: Department and Research Institute of Rehabilitation Medicine, Brain Research Institute and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. srcho918@yumc.yonsei.ac.kr
authors.forename: Sung-Rae
authors.initials: SR
authors.lastname: Cho
authors.forename: Mal Sook
authors.initials: MS
authors.lastname: Yang
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Yim
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Park
authors.forename: Jong Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: Young-Woo
authors.initials: YW
authors.lastname: Eom
authors.forename: In Keun
authors.initials: IK
authors.lastname: Jang
authors.forename: Hyo Eun
authors.initials: HE
authors.lastname: Kim
authors.forename: Joon Seong
authors.initials: JS
authors.lastname: Park
authors.forename: Hyun Ok
authors.initials: HO
authors.lastname: Kim
authors.forename: Bae Hwan
authors.initials: BH
authors.lastname: Lee
authors.forename: Chang-Il
authors.initials: CI
authors.lastname: Park
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002454:Cell Differentiation; D002478:Cells, Cultured; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D004594:Electrophysiology / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005904:Glial Fibrillary Acidic Protein / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009043:Motor Activity / Q000502:physiology; D004676:Myelin Basic Protein / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000601:surgery*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*
chemical_list: D005904:Glial Fibrillary Acidic Protein; D004676:Myelin Basic Protein