title: Synthesis, chiral separation, and absolute configuration of bis-(N-aryl) atropisomeric triads: 1,2-bis-[4-methyl-2-(thi)oxo-2,3-dihydrothiazol-3-yl]-benzene.
abstract: In this work, a series of 1,2-bis-[4-methyl-2-(thi)oxo-2,3-dihydrothiazol-3-yl]-benzene has been prepared. These atropisomeric molecular triads were exclusively found to exist in the anti-form. They were separated into enantiomers by liquid chromatography on a chiral support. The absolute configurations of the enantiomers were determined using a chemical correlation method together with chiral chromatography. The barriers to interconversion of the enantiomers were determined.
authors.affiliation: Laboratoire de Stéréochimie Dynamique et Chiralité, Chirosciences UMR 6263, Université Paul Cézanne, Aix-Marseille III, Marseille, France. christian.roussel@univ-cezanne.fr
authors.forename: Christian
authors.initials: C
authors.lastname: Roussel
authors.forename: Radia
authors.initials: R
authors.lastname: Kaid-Slimane
authors.forename: Federico
authors.initials: F
authors.lastname: Andreoli
authors.forename: Mailis
authors.initials: M
authors.lastname: Renaudin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Vanthuyne