title: Is there a need for dietary measures to further reduce LDL cholesterol in patients with type II diabetes mellitus on statin therapy?
abstract: OBJECTIVE
  To study the need for dietary measures to further reduce LDL cholesterol in patients with type 2 diabetes mellitus on statin therapy.
  
  
  METHODS
  A Pubmed, Embase, CINAHL and Cochrane library search was performed to identify relevant articles. After critical appraisal six articles were ranked according to relevance, validation and level of evidence.
  
  
  RESULTS
  There were no studies performed among type II diabetics. Among patients with hypercholesterolaemia, diet led to an additional LDL reduction from 0.20 to 0.88 mmol/l, translating into 23% reduction in vascular risk.
  
  
  CONCLUSIONS
  We recommend a low-fat diet on top of statin therapy in patients with type 2 diabetes mellitus assuming that effects found in hypercholesterolaemic patients also apply to type 2 diabetics.
authors.affiliation: Julius Center for Health Sciences and Primary Care, Str. 6.131, Heidelberglaan 100, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Winters
authors.forename: Hannah
authors.initials: H
authors.lastname: Visser
authors.forename: Anke H M
authors.initials: AH
authors.lastname: Steerneman
authors.forename: Gregory
authors.initials: G
authors.lastname: Thomas
authors.forename: Michiel L
authors.initials: ML
authors.lastname: Bots
authors.forename: Geert J
authors.initials: GJ
authors.lastname: van der Heijden
mesh_terms: D008078:Cholesterol, LDL / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000188:drug therapy; D018752:Diet, Fat-Restricted; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000178:diet therapy* / Q000188:drug therapy; D008297:Male; D016896:Treatment Outcome
chemical_list: D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors