title: Association between hypermutator phenotype, clinical variables, mucoid phenotype, and antimicrobial resistance in Pseudomonas aeruginosa.
abstract: The presence of hypermutator Pseudomonas aeruginosa was associated with poorer lung function in patients at the Adult West Midlands CF Unit. Mucoid isolates were more likely to be hypermutators. The presence of resistant mutant subpopulations was associated with hypermutator phenotype but was not good enough to be used as a test for this phenotype.
authors.affiliation: Department of Biological Sciences, Warwick University, Coventry CV4 7AL, United Kingdom. djwaine@doctors.org.uk
authors.forename: David J
authors.initials: DJ
authors.lastname: Waine
authors.forename: David
authors.initials: D
authors.lastname: Honeybourne
authors.forename: E Grace
authors.initials: EG
authors.lastname: Smith
authors.forename: Joanna L
authors.initials: JL
authors.lastname: Whitehouse
authors.forename: Chris G
authors.initials: CG
authors.lastname: Dowson
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis*; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D012372:ROC Curve; D012129:Respiratory Function Tests
chemical_list: D011135:Polysaccharides, Bacterial