Dietary resistant starch reduces levels of glucose-dependent insulinotropic polypeptide mRNA along the jejunum-ileum in both normal and type 2 diabetic rats.
It has been reported that the circulating glucose-dependent insulinotropic polypeptide (GIP) levels were reduced by an intake of some foods/drugs capable of delaying carbohydrate digestion/absorption. In this study, we revealed that feeding rats with dietary resistant starch reduced the GIP mRNA levels along the entire length of the jejunoileum in both Wistar and type 2 diabetic GK rats.
Shimada
Masaya
M
Laboratory of Nutritional Physiology, Graduate School of Nutritional and Environmental Sciences, Global COE Program, University of Shizuoka, Japan.
Mochizuki
Kazuki
K
Goda
Toshinao
T
D000821:Animal Feed; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology* / Q000235:genetics; D005749:Gastric Inhibitory Polypeptide / Q000031:analogs & derivatives* / Q000235:genetics / Q000378:metabolism*; D007082:Ileum / Q000201:enzymology*; D007583:Jejunum / Q000201:enzymology*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D013213:Starch / Q000494:pharmacology*
D012333:RNA, Messenger; D005749:Gastric Inhibitory Polypeptide; D013213:Starch