A new constrained proline analogue with an 8-azabicyclo[3.2.1]octane skeleton.
A straightforward synthesis of 8-azabicyclo[3.2.1]octane-1-carboxylic acid, a new proline analogue with a bicyclic structure, is described. The procedure makes use of readily available starting materials and involves simple, high-yielding transformations.
Casabona
Diego
D
Departamento de Química Orgánica, Instituto de Ciencia de Materiales de Aragón, Universidad de Zaragoza-CSIC, 50009 Zaragoza, Spain.
Jiménez
Ana I
AI
Cativiela
Carlos
C