Glycopeptide insensitive Staphylococcus aureus subdural empyema treated with linezolid and rifampicin.
A 4-year-old boy had surgical debulking of a cerebral astrocytoma followed by chemotherapy. He developed a subdural empyema with a teicoplanin and methicillin resistant Staphylococcus aureus. He was successfully treated with surgical drainage and 6 weeks of antibiotic therapy which included linezolid, rifampicin and metronidazole. Linezolid may be successful in treating other CNS infections caused by antibiotic resistant gram-positive organisms.
Gallagher
R M
RM
Department of Infectious Diseases, Royal Liverpool Children's Hospital, Liverpool, L12 2AP, UK.
Pizer
B
B
Ellison
J A
JA
Riordan
F A I
FA
D000081:Acetamides / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D004322:Drainage; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D013354:Empyema, Subdural / Q000382:microbiology* / Q000628:therapy*; D006801:Humans; D000069349:Linezolid; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000627:therapeutic use*; D012293:Rifampin / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy*; D017334:Teicoplanin / Q000627:therapeutic use
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D017334:Teicoplanin; D000069349:Linezolid; D012293:Rifampin