[Distribution and drug resistance of pathogens in lower respiratory tract infection in neonates].
OBJECTIVE
To investigate the epidemiological characteristics of pathogens and their antimicrobial susceptibility in neonates with lower respiratory tract infection (LRTI).


METHODS
Sputum specimens for bacterial cultures were collected from 1173 neonates with LRTL between January 2005 and December 2006. Antibiotic susceptibility tests were performed after bacteria had been identified.


RESULTS
A total of 707 pathogenic strains (60.3%) were identified, including 521 (73.7%) Gram-negative bacilli, 106 (15.0%) Gram-positive bacilli, and 80 (11.3%) fungi. E Coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and enteric bacilli were common cultured Gram-negative bacilli. Most strains of Gram-negative bacilli were susceptible to meropenem, piperacillin/tazobactam, the fourth generation cephalosporin, cebfoperazone/sulbactam and amikacin. Staphylococcus aureus and coagula-negative staphylococci (CNS) were common in the cultured Gram-positive bacilli. Staphylococcus aureus and CNS were susceptible to vancomycin, ciprofloxacin and piperacillin/tazobactam but were resistant to Penicillin.


CONCLUSIONS
Gram-negative bacilli predominate the pathogens of LRTI in neonates. E Coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa are major pathogens.
Yang
Yu-Xia
YX
Department of Pediatrics, Third Hospital Affiliated to Zhengzhou University, Zhengzhou 450052, China. yyx6873@sina.com.cn
Qiao
Jun-Ying
JY
Cheng
Xiu-Yong
XY
Wang
Xin-Xia
XX
D001419:Bacteria / Q000302:isolation & purification*; D024881:Drug Resistance, Bacterial; D025141:Drug Resistance, Fungal; D005658:Fungi / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology*