Primary malignant peripheral nerve sheath tumor with eosinophilic cytoplasmic globules arising from the greater omentum in a dog.
A 10-year-old Golden Retriever dog had a solitary tumor mass arising from the greater omentum. Histologically, the tumor showed varying cellularity and patterns of cellular arrangement. In dense cellular areas, spindle-shaped cells were arranged in interlacing bundles. The sparse cellular area was characterized by loosely arranged fusiform cells. The neoplastic cells frequently contained PAS-positive eosinophilic globules in the cytoplasm, and mitotic figures were frequently observed. The tumor cells were positive to vimentin, S-100 protein, glial fibrillary acidic protein, myelin basic protein, neuron-specific enolase and myoglobin. The present tumor was diagnosed as a malignant peripheral nerve sheath tumor (MPNST) with eosinophilic cytoplasmic globules arising from the greater omentum. To our knowledge, this may be the first case of primary omental MPNST in domestic animals.
Sugiyama
Akihiko
A
Department of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Minami 4-101, Koyama-cho, Tottori, Japan. sugiyama@muses.tottori-u.ac.jp
Morita
Takehito
T
Shimada
Akinori
A
Tsuka
Takeshi
T
Okamoto
Yoshiharu
Y
Takeuchi
Takashi
T
D000818:Animals; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D018317:Nerve Sheath Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D009852:Omentum / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*