title: [Interrelation between the pathways of isoprenoid biosynthesis and carbon source catabolism in anaerobic and facultatively anaerobic bacteria].
abstract: Data on the interrelation between the pathways of the carbon source catabolism and isoprenoid biosynthesis in anaerobic and facultatively anaerobic bacteria were obtained. Two pathways of isoprenoid biosynthesis (nonmevalonate and mevalonate) were revealed in the representatives of the genus Clostridium. The non-mevalonate pathway of isoprenoid biosynthesis and the glycolytic pathway of substrate oxidation are typical of glucose-grown bacteria, whereas the pentose phosphate cycle operates in xylose-grown bacteria. The mevalonate pathway of isoprenoid biosynthesis was revealed in strain Clostridium thermosaccharolyticum DSM 571 grown in the presence of mevinolin, as well as in a number of lactic acid bacteria. Mevinolin is known to react with the lactate dehydrogenase complex, preventing reduction of pyruvate. The nonmevalonate pathway of isoprenoid biosynthesis was revealed in Bifidobacterium bifidum. The role of different metabolic pathways in isoprenoid biosynthesis is discussed.
authors.forename: S M
authors.initials: SM
authors.lastname: Trutko
authors.forename: V A
authors.initials: VA
authors.lastname: Shcherbakova
authors.forename: I V
authors.initials: IV
authors.lastname: Ivanova
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Lysanskaia
authors.forename: O V
authors.initials: OV
authors.lastname: Arkhipova
authors.forename: N A
authors.initials: NA
authors.lastname: Chuvil'skaia
authors.forename: B P
authors.initials: BP
authors.lastname: Baskunov
authors.forename: D N
authors.initials: DN
authors.lastname: Ostrovskiĭ
authors.forename: V K
authors.initials: VK
authors.lastname: Akimenko
mesh_terms: D001421:Bacteria, Anaerobic / Q000254:growth & development / Q000378:metabolism*; D002244:Carbon / Q000378:metabolism; D003013:Clostridium / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D007778:Lactobacillus / Q000378:metabolism; D008798:Mevalonic Acid / Q000378:metabolism; D010427:Pentose Phosphate Pathway; D013379:Substrate Specificity; D013729:Terpenes / Q000378:metabolism*; D014994:Xylose / Q000378:metabolism*
chemical_list: D013729:Terpenes; D002244:Carbon; D014994:Xylose; D005947:Glucose; D008798:Mevalonic Acid