title: Photoswitched DNA-binding of a photochromic spiropyran.
abstract: The dramatically different DNA-binding properties of the two isomeric forms of a photochromic spiropyran have been demonstrated, enabling photoswitched DNA binding. The closed, UV-absorbing form shows no signs of interaction with DNA. Upon UV exposure the spiropyran is isomerized to the open form that binds to DNA by intercalation. The process is fully reversible as the corresponding dissociation process is induced by visible light.
authors.affiliation: Department of Chemical and Biological Engineering, Physical Chemistry, Chalmers University of Technology, SE-412 96 Göteborg, Sweden.
authors.forename: Johanna
authors.initials: J
authors.lastname: Andersson
authors.forename: Shiming
authors.initials: S
authors.lastname: Li
authors.forename: Per
authors.initials: P
authors.lastname: Lincoln
authors.forename: Joakim
authors.initials: J
authors.lastname: Andréasson
mesh_terms: D001578:Benzopyrans / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D004247:DNA / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D007211:Indoles / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D009574:Nitro Compounds / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D010777:Photochemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001578:Benzopyrans; D007211:Indoles; D009574:Nitro Compounds; C088184:spiropyran; D004247:DNA; C427203:calf thymus DNA