title: Two-dimensional chromatography of complex polymers 6. Method development for (meth)acrylate-based copolymers.
abstract: The free-radical copolymerisation of various acrylates and methacrylates resulting in complex copolymers for cosmetic applications were investigated using different chromatographic techniques including HPLC and on-line coupled two-dimensional (2D) liquid chromatography. The complete separation of all polymerisation products was achieved by gradient HPLC. A computated optimisation procedure, using the Polymer Chromatographic Model allowed us to design a step mobile phase gradient to improve resolution of homopolymer chromatographic separation. By combining gradient HPLC and SEC (Size Exclusion Chromatography) in a fully automated two-dimensional chromatography setup, the complex distributions of chemical composition and molar mass could be simultaneously described and fingerprinted.
authors.affiliation: German Institute for Polymers, Schlossgartenstrasse 6, 64289 Darmstadt, Germany.
authors.forename: Jacques-Antoine
authors.initials: JA
authors.lastname: Raust
authors.forename: Adele
authors.initials: A
authors.lastname: Brüll
authors.forename: Claudine
authors.initials: C
authors.lastname: Moire
authors.forename: Céline
authors.initials: C
authors.lastname: Farcet
authors.forename: Harald
authors.initials: H
authors.lastname: Pasch
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002853:Chromatography, Liquid / Q000379:methods*; D011109:Polymethacrylic Acids / Q000737:chemistry*
chemical_list: D011109:Polymethacrylic Acids