title: Anesthetic management of an obstetric patient with MELAS syndrome: case report and literature review.
abstract: Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS syndrome) is a mitochondrial disorder associated with neurologic, cardiac, neuromuscular, hepatic, metabolic and gastrointestinal dysfunction and potential anesthetic and obstetric complications. The case of a parturient with MELAS syndrome requiring labor analgesia is presented. A Medline literature search limited to the English language was undertaken to review cases of MELAS syndrome. Based on our experience and literature review, parturients with MELAS syndrome appear to benefit from neuraxial analgesia and anesthesia, which blunt excessive oxygen consumption and acidosis.
authors.affiliation: Department of General Anesthesiology and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. maurtum@ccf.org
authors.forename: M
authors.initials: M
authors.lastname: Maurtua
authors.forename: A
authors.initials: A
authors.lastname: Torres
authors.forename: V
authors.initials: V
authors.lastname: Ibarra
authors.forename: G
authors.initials: G
authors.lastname: DeBoer
authors.forename: J
authors.initials: J
authors.lastname: Dolak
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical / Q000379:methods*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D017241:MELAS Syndrome / Q000150:complications* / Q000503:physiopathology; D010101:Oxygen Consumption; D011247:Pregnancy; D011248:Pregnancy Complications; D015742:Propofol / Q000494:pharmacology
chemical_list: D015742:Propofol