Huxley's revenge: cell-cycle entry, positive feedback, and the G1 cyclins.
In a recent issue of Nature, Skotheim et al. (2008) show that a transcriptional positive feedback loop plays a key role in the commitment to enter the yeast cell cycle.
Carey
Lucas B
LB
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5222, USA.
Leatherwood
Janet K
JK
Futcher
Bruce
B
D002453:Cell Cycle; D056746:Cyclin G; D056766:Cyclin G1; D016213:Cyclins / Q000378:metabolism*; D025461:Feedback, Physiological; D006801:Humans; D011401:Promoter Regions, Genetic / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
C534702:CCNG1 protein, human; D056746:Cyclin G; D056766:Cyclin G1; D016213:Cyclins; D014157:Transcription Factors