title: Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes.
abstract: An optimized noninvasive Raman microscope was used to evaluate tumor targeting and localization of single walled carbon nanotubes (SWNTs) in mice. Raman images were acquired in two groups of tumor-bearing mice. The control group received plain-SWNTs, whereas the experimental group received tumor targeting RGD-SWNTs intravenously. Raman imaging commenced over the next 72 h and revealed increased accumulation of RGD-SWNTs in tumor ( p < 0.05) as opposed to plain-SWNTs. These results support the development of a new preclinical Raman imager.
authors.affiliation: Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, 1201 Welch Road, Stanford, California 94305-5484, USA.
authors.forename: C
authors.initials: C
authors.lastname: Zavaleta
authors.forename: A
authors.initials: A
authors.lastname: de la Zerda
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Keren
authors.forename: Z
authors.initials: Z
authors.lastname: Cheng
authors.forename: M
authors.initials: M
authors.lastname: Schipper
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Dai
authors.forename: S S
authors.initials: SS
authors.lastname: Gambhir
mesh_terms: D000818:Animals; D051379:Mice; D037742:Nanotubes, Carbon; D009374:Neoplasms, Experimental / Q000628:therapy*; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D037742:Nanotubes, Carbon