Myocardial infarction and arterial thrombosis in identical newborn twins with homozygosity for the PAI-1 4 G/5 G polymorphism.
Myocardial infarction in the perinatal period, in the absence of congenital heart disease or coronary artery lesions, is rare. The most common etiology described are the thromboembolism and perinatal asphyxia. We report a case of monozygotic twins who developed, after birth, acute vascular events and both had PAI-1 4G/4G homozygosity.
De Lucia
Vittoria
V
Andreassi
Maria Grazia
MG
Sabatini
Laura
L
Ait-Ali
Lamia
L
Spadoni
Isabella
I
Giusti
Sandra
S
D000328:Adult; D004200:Diseases in Twins / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006720:Homozygote; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000235:genetics*; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D013927:Thrombosis / Q000175:diagnosis / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*
D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human