[Three cases of stomatitis caused by chemotherapy for gastrointestinal cancer that responded well to lafutidine].
We described 3 cases of stomatitis caused by chemotherapy with the fluoropyrimidine preparation S-1, alone or combined with other anticancer drugs. The stomatitis did not respond to conventional oral mucosal treatment such as triamcinolone acetonide(Kenalog)or allopurinol, but improved after treatment with the histamine H2-receptor antagonist lafutidine. The concurrent use of lafutidine allowed these 3 patients to continue chemotherapy with no recurrence of stomatitis. We concluded that lafutidine may be a viable treatment option for chemotherapy-induced stomatitis, allowing treatment to be continued.
Uchida
Kazumi
K
Dept. of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University.
Hayashi
Kazuhiko
K
Kuramochi
Hidekazu
H
Nakajima
Go
G
Yamamoto
Masakazu
M
D000081:Acetamides / Q000627:therapeutic use*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D013280:Stomatitis / Q000150:complications* / Q000188:drug therapy*
D000081:Acetamides; D010880:Piperidines; D011725:Pyridines; C076948:lafutidine