title: Illuminating the black box of TNF action in tuberculous granulomas.
abstract: TNF clearly contributes to immunity to intracellular pathogens, but how it does so is incompletely understood. In this issue of Immunity, Clay et al. (2008) provide unique insights, using intravital microscopy and the zebrafish-embryo model of tuberculosis.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Miller
authors.forename: Joel D
authors.initials: JD
authors.lastname: Ernst
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D004625:Embryo, Nonmammalian; D006099:Granuloma / Q000276:immunology* / Q000378:metabolism; D018398:Homeodomain Proteins / Q000276:immunology / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D009165:Mycobacterium Infections, Nontuberculous / Q000276:immunology* / Q000382:microbiology; D019910:Mycobacterium marinum / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000378:metabolism*; D015027:Zebrafish / Q000196:embryology / Q000276:immunology / Q000378:metabolism / Q000382:microbiology
chemical_list: D018398:Homeodomain Proteins; D014409:Tumor Necrosis Factor-alpha