Hypothyroidism induces selective oxidative stress in amygdala and hippocampus of rat.
The effects of hypothyroidism on lipid peroxidation (LP), reactive oxygen species (ROS), and nitric oxide synthase (NOS), levels and expression, in rat brain were examined. Hypothyroidism was induced by administering methimazole in drinking water (60 mg/kg/day). In striatum, motor cortex and cerebellum of hypothyroid rats LP was not modified, whereas LP and ROS increased in amygdala and hippocampus of hypothyroid rats at the third week of treatment with methimazole as compared to euthyroid group values. Regarding NOS participation, only hippocampal constitutive-NOS activity was increased, accompanied by an augmentation in nNOS expression. Results show that hypothyroidism induces selective oxidative stress in both the hippocampus and amygdala, where the nitrergic system is involved.
Cano-Europa
Edgar
E
Departamento de Fisiología "Mauricio Russek", Escuela Nacional de Ciencias Biológicas, IPN, Prol. Carpio y Plan de Ayala, s/n, cp. 11340 Mexico City, Mexico.
Pérez-Severiano
Francisca
F
Vergara
Paula
P
Ortiz-Butrón
Rocío
R
Ríos
Camilo
C
Segovia
José
J
Pacheco-Rosado
Jorge
J
D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D013956:Antithyroid Agents; D001831:Body Temperature / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism*; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008713:Methimazole; D052248:Nitric Oxide Synthase Type I / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism
D013956:Antithyroid Agents; D017382:Reactive Oxygen Species; D008713:Methimazole; D052248:Nitric Oxide Synthase Type I; D052250:Nitric Oxide Synthase Type III