Interrelations of mitochondrial fragmentation and cell death under ischemia/reoxygenation and UV-irradiation: protective effects of SkQ1, lithium ions and insulin.
Mitochondria-targeted antioxidant 10-(6-plastoquinonyl)decyltriphenyl-phosphonium (SkQ1) as well as insulin and the inhibitor of glycogen-synthase kinase, Li(+) are shown to (i) protect renal tubular cells from an apoptotic death and (ii) diminish mitochondrial fission (the thread-grain transition) induced by ischemia/reoxygenation. However, SkQ1 and LiCl protected the mitochondrial reticulum of skin fibroblasts from ultraviolet-induced fission but were ineffective in preventing a further cell death. This means that mitochondrial fission is not essential for apoptotic cascade progression.
Plotnikov
E Y
EY
A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia.
Vasileva
A K
AK
Arkhangelskaya
A A
AA
Pevzner
I B
IB
Skulachev
V P
VP
Zorov
D B
DB
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D019610:Cytoprotection; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004848:Epithelium / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D005347:Fibroblasts / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D038341:Glycogen Synthase Kinases / Q000037:antagonists & inhibitors; D007328:Insulin / Q000494:pharmacology*; D007684:Kidney Tubules / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D018021:Lithium Chloride / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure*; D010100:Oxygen / Q000378:metabolism; D010971:Plastoquinone / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D014466:Ultraviolet Rays
C532038:10-(6'-plastoquinonyl)decyltriphenylphosphonium; D000975:Antioxidants; D004791:Enzyme Inhibitors; D007328:Insulin; D038341:Glycogen Synthase Kinases; D018021:Lithium Chloride; D010971:Plastoquinone; D010100:Oxygen