title: [Lung disease and HIV infection in children at the Charles de Gaulle university pediatric hospital center in Ouagadougou (Burkina Faso)].
abstract: To compare the clinical and radiological aspects of lung diseases in HIV-positive and HIV-negative children, we conducted a retrospective case control study covering a 3-year period from January 2003 through December 2005 at Charles de Gaulle University Pediatric Hospital Center in Ouagadougou. HIV-positive patients hospitalised for lung disease were matched to HIV-negative patients controls, hospitalised for the same symptoms, by age and date of hospitalisation. The study included 186 patients (93 HIV-positive and 93 HIV-negative) and collected data on age, sex, clinical signs, radiological signs and short-term course. Of the 93 HIV-positive children suspected to have been contaminated by mother-to-child transmission, 92 had HIV1 and 1 had a double infection of HIV1 and 2. The mean age in both groups was 48 months. Clinically severe lung disease (44%) was more common in HIV-positive children. Radiology showed that interstitial syndrome was significantly more common in HIV-positive children (p=0001) with a sensitivity of 71% and a specificity of 60%. The case-fatality rate was 4.2% among HIV-positive children. This study allows us to remind paediatricians of the importance of lung disease in HIV-infected children. Moreover, the vertical transmission responsible for disease in all our patients shows the need to accelerate the scaling up of the program for prevention of mother-to-child HIV transmission in our country.
authors.affiliation: Unité de formation et de recherche en sciences de la santé (UFR/SDS), Université de Ouagadougou, Service de pédiatrie médicale du CHUP-CDG, BP 1198 BP 01, Ouagadougou 01 Burkina Faso. kouetafla@yahoo.com
authors.forename: Fla
authors.initials: F
authors.lastname: Kouéta
authors.forename: Diarra
authors.initials: D
authors.lastname: Yé
authors.forename: Lassina
authors.initials: L
authors.lastname: Dao
authors.forename: Alice
authors.initials: A
authors.lastname: Zoungrana-Kaboré
authors.forename: Sylvie Armelle P
authors.initials: SA
authors.lastname: Ouédraogo
authors.forename: M
authors.initials: M
authors.lastname: Napon
authors.forename: Alphonse
authors.initials: A
authors.lastname: Sawadogo
mesh_terms: D002050:Burkina Faso / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology* / Q000635:transmission; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications / Q000401:mortality; D015497:HIV-1; D015498:HIV-2; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008171:Lung Diseases / Q000453:epidemiology*; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology; D012189:Retrospective Studies