[Late-onset vaccination-induced subcutaneous pseudolymphoma].
Persistent subcutaneous nodules arise on rare occasions at sites of injection of aluminium hydroxide-adsorbed vaccine. We report a case following a diphtheria, tetanus and pertussis vaccination. The late onset of the lesion, four years after the injection, led to an uncertain preoperative diagnosis. Histopathologic examination showed features of a subcutaneous pseudolymphoma. The demonstration of aluminium by Morin staining and atomic absorption spectrometry on a paraffin-embedded tissue probe supported the diagnosis of a vaccination-induced pseudolymphoma.
Croce
Sabrina
S
Département de pathologie, CHU de Strasbourg, hôpital de Hautepierre, 1, avenue Molière, 67098 Strasbourg cedex, France.
Lhermitte
Benoît
B
Tomasetto
Catherine
C
Guillard
Olivier
O
Bellocq
Jean-Pierre
JP
Chenard
Marie-Pierre
MP
D000535:Aluminum; D004396:Coloring Agents; D003937:Diagnosis, Differential; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D019310:Pseudolymphoma / Q000139:chemically induced* / Q000473:pathology*; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology
D004396:Coloring Agents; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D000535:Aluminum