Fibrillary glomerulonephritis with hepatitis C viral infection and hypocomplementemia.
Fibrillary glomerulonephritis (FGN) is a relatively rare cause of renal disease, found in only 0.6-1.5% of native renal biopsies. The pathogenesis of FGN is not well described, and very few associations with disease processes other than hepatitis C virus (HCV) have been made. We describe a case that provides evidence in support of the FGN-HCV association, as well as introduces the association of FGN-HCV and hypocomplementemia. The case is a 53-year-old African-American female demonstrating a classical presentation of FGN complicated by a concomitant HCV infection. Treating an HCV infection with alpha-interferon has been shown to result in subsequent improvement in the nephrotic syndrome and renal function. However, this patient is unique in that she is complicated with hypocomplementemia, creating a complex treatment situation.
Ray
Susan
S
Department of Medicine, Akron General Medical Center, Akron, Ohio 44307, USA.
Rouse
Kelly
K
Appis
Andrew
A
Novak
Robert
R
Haller
Nairmeen Awad
NA
D001707:Biopsy, Needle; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000150:complications* / Q000473:pathology* / Q000628:therapy; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007105:Immune Complex Diseases / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D007074:Immunoglobulin G / Q000032:analysis; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods; D018570:Risk Assessment
D007074:Immunoglobulin G