Tuberculosis associated hemophagocytic syndrome in infancy.
An infant presented with prolonged fever, generalized lymphadenopathy, splenohepatomegaly, anemia and seborrheic dermatitis. Investigations including bone marrow findings confirmed the diagnosis of hemo-phagocytic syndrome (HPS) and the infant succumbed. Liver biopsy features of epithelioid granuloma and positive AFB culture of gastric aspirate confirmed the diagnosis of tuberculosis (TB). This rare association of HPS and tuberculosis in infancy is reported.
Balasubramanian
S
S
Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India. sbsped53@sify.com
Kaarthigeyan
K
K
Aparna
V
V
Srinivas
S
S
D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000097:blood / Q000382:microbiology*; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000150:complications*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M