Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic beta-cell function in type 2 diabetic mice.
Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) was isolated from Artemisia princeps to investigate the dose-response effects on blood glucose regulation and pancreatic beta-cell function in type 2 diabetic mice. Db/db mice were divided into control (eupatilin-free, AIN-76 standard diet), low-Eupa (0.005g/100g diet) and high-Eupa (0.02g/100g diet) groups. The supplementation of eupatilin for 6 weeks significantly lowered fasting blood glucose concentration while it increased hepatic glycogen content. In particular, high-Eupa reduced hemoglobin A(1c) and plasma glucagon levels along with a simultaneous increase in plasma insulin and adiponectin levels. The supplementation of eupatilin significantly lowered hepatic glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities, while it increased glucokinase activity in the liver. The pancreatic insulin concentration was higher in the eupatilin-supplemented groups. Also the pancreatic insulin concentration of eupatilin groups was higher than the control group. These results suggest that eupatilin played the role of an antidiabetic functional component in A. princeps by enhancing hepatic and plasma glucose metabolism as well as by increasing insulin secretion in type 2 diabetic mice.
Kang
Young-Jin
YJ
Department of Food Science and Nutrition, Kyungpook National University, Daegu 702-701, South Korea.
Jung
Un Ju
UJ
Lee
Mi-Kyung
MK
Kim
Hye-Jin
HJ
Jeon
Seon-Min
SM
Park
Yong Bok
YB
Chung
Hae-Gon
HG
Baek
Nam-In
NI
Lee
Kyung Tae
KT
Jeong
Tae-Sook
TS
Choi
Myung-Sook
MS
D000818:Animals; D019306:Artemisia / Q000737:chemistry*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004435:Eating / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D020799:Pancrelipase / Q000378:metabolism; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism
D001786:Blood Glucose; D005419:Flavonoids; D005947:Glucose; D005952:Glucose-6-Phosphatase; D006442:Glycated Hemoglobin; D007328:Insulin; D008112:Liver Glycogen; D020799:Pancrelipase; D010729:Phosphoenolpyruvate Carboxykinase (GTP); C045325:eupatilin