title: Commensal bacteria and "oncologic surveillance": suggestions from an experimental model.
abstract: The relationship between resident intestinal flora and colon cancer development are not yet clear. Apoptosis induction could represent a mechanism by which commensal and/or probiotic bacteria could prevent proliferation of dysplastic cells. In the present study, the in vivo and in vitro proapoptotic effect of resident bacteria was evaluated in mouse colon mucosa. Preliminary results suggest that colonic apoptosis induction, by commensal bacteria, could possibly represent a physiologic "oncologic surveillance" mechanism for colonic proliferative disease prevention.
authors.affiliation: II School of Medicine, University of Rome La Sapienza, Rome, Italy. cristiano.pagnini@uniroma1.it
authors.forename: Cristiano
authors.initials: C
authors.lastname: Pagnini
authors.forename: Vito D
authors.initials: VD
authors.lastname: Corleto
authors.forename: Sharon B
authors.initials: SB
authors.lastname: Hoang
authors.forename: Rubina
authors.initials: R
authors.lastname: Saeed
authors.forename: Fabio
authors.initials: F
authors.lastname: Cominelli
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Delle Fave
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology; D017209:Apoptosis; D053148:Caspase 3 / Q000378:metabolism; D053453:Caspase 9 / Q000378:metabolism; D003106:Colon / Q000187:drug effects / Q000382:microbiology*; D003110:Colonic Neoplasms / Q000382:microbiology* / Q000517:prevention & control*; D015169:Colony Count, Microbial; D004269:DNA, Bacterial / Q000032:analysis; D004195:Disease Models, Animal; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology*; D051379:Mice; D008806:Mice, Inbred AKR; D009924:Organ Culture Techniques / Q000379:methods; D019936:Probiotics
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D053148:Caspase 3; D053453:Caspase 9