title: Adenosinergic modulation of respiratory activity: developmental plasticity induced by perinatal caffeine administration.
abstract: Caffeine is an adenosine receptor antagonist that is commonly used in the clinic as a respiratory stimulant to treat apnea of prematurity. A recent clinical study showed that newborns treated with caffeine present no neuro-developmental disabilities at 2 years of age in comparison to placebo-treated children [Schmidt, B., Roberts, R.S., Davis, P., Doyle, L.W., Barrington, K.J., Ohlsson, A., Solimano, A., Tin, W., 2007. Long-term effects of caffeine therapy for apnea of prematurity. N. Engl. J. Med. 357, 1893-1902]. Although neonatal caffeine administration in this population is associated with clear short- and long-term health improvements, the consequences of this treatment on basic homeostatic functions such as respiratory regulation are unknown. This article reviews evidence indicating that neonatal caffeine treatment modifies respiratory control development and that these changes persist until adulthood. The mechanisms contributing to this form of developmental plasticity are unknown but current data indicate that caffeine treatment, especially during the perinatal period, alters adenosinergic neuromodulation of the respiratory control system. While human data show that neonatal caffeine treatment is relatively safe for some aspects of neural development, the results obtained in animal studies raise important questions pertaining to the potential long-term effects of this treatment on the respiratory control system.
authors.affiliation: Department of Physiology, University of Toronto, Laboratory for Sleep and Respiratory Neurobiology, Medical Sciences Building, Room 7308, 1, King's College Circle, Toronto, ON M5S 1A8, Canada. gaspard.montandon@utoronto.ca
authors.forename: Gaspard
authors.initials: G
authors.lastname: Montandon
authors.forename: Richard
authors.initials: R
authors.lastname: Kinkead
authors.forename: Aida
authors.initials: A
authors.lastname: Bairam
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002110:Caffeine / Q000008:administration & dosage*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects*; D018047:Receptors, Purinergic P1 / Q000502:physiology*; D012137:Respiratory System / Q000187:drug effects*
chemical_list: D000697:Central Nervous System Stimulants; D018047:Receptors, Purinergic P1; D002110:Caffeine