title: Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population.
abstract: Alzheimer's disease (AD) is the most common neurodegenerative disorders in the elderly. Low-density lipoprotein receptor-related protein (LRP), as a receptor of apolipoprotein E (APOE), APP, and alpha2 macroglobulin (alpha2-M), keeps the balance between degeneration and production of beta-amyloid protein (Abeta) clearance. Its gene had been defined as a candidate gene for AD, but the results were not universal. Total 496 AD patients and 478 controls were recruited in Chinese Han population and real-time PCR was used to detect the polymorphism of LRP C766T. Multiple logistic regression, Chi-square test and survival analysis were performed to explore the association. The distribution of LRP genotypes and alleles was significantly different between cases and controls, and T allele could reduce the risk for developing AD (OR of CT genotype: 0.57; 95% CI: 0.38-0.85, rho=0.003; OR of T allele: 0.57; 95% CI: 0.39-0.83, rho=0.003). TT genotype carriers had 5 years later for developing AD compared with CC genotype carriers, but survival analysis did not conform this (LRP TT vs. CT and CC log rank chi(2)=2.71, rho=0.26). The distribution of LRP C766T genotypes and alleles was different among different severity stratified by MMSE yet (rho=0.26). Our data suggested that the polymorphism of LRP C766T was strongly associated with AD and T allele might be a protective factor for AD in Chinese Han population.
authors.affiliation: Department of Neurology and Neurobiology, Key Laboratory of Neurodegenerative Diseases for Ministry of Education, Beijing Institute of Geriatrics and Xuanwu Hospital of Capital University of Medical Sciences, 100053 Beijing, China.
authors.forename: Yong-Tao
authors.initials: YT
authors.lastname: Zhou
authors.forename: Zhen-Xin
authors.initials: ZX
authors.lastname: Zhang
authors.forename: Piu
authors.initials: P
authors.lastname: Chan
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: He
authors.forename: Mou-Ni
authors.initials: MN
authors.lastname: Tang
authors.forename: Cheng-Bin
authors.initials: CB
authors.lastname: Wu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D044466:Asian People / Q000208:ethnology; D016001:Confidence Intervals; D018572:Disease-Free Survival; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D026503:Low Density Lipoprotein Receptor-Related Protein-1