[Survival prediction and related risk factors of amyotrophic lateral sclerosis:analysis of 65 cases].
OBJECTIVE
To investigate the mean survival time and risk factors of amyotrophic lateral sclerosis (ALS).


METHODS
Sixty-five ALS patients were followed up, and the clinical data of 33 of them who died were retrospectively analyzed. The survival time and related risk factors were analysed with the statistic tools such as Kaplan-Meier survival curve, t test, and variance analysis.


RESULTS
The mean survival time of the 33 patients was (35 +/- 19) months from onset of symptom. The mean survival time for the patients <60 years old was (39 +/- 19) months; not significantly different from that of the patients aged > or =60 years [(30 +/- 18) months, P > 0.05]. The mean survival time from confirmed diagnosis was (22 +/- 17) months. The risk factors influencing the survival time of ALS patients were age, site of onset, severity of disease, and interval between symptom onset and diagnosis.


CONCLUSIONS
The prognosis of the ALS patients with elder age, bulbar onset, more severe symptoms and signs, and shorter confirmation time is poorer.
Qiao
Lei
L
Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhang
Jun
J
Fan
Dong-Sheng
DS
D000328:Adult; D000367:Age Factors; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate