title: Evolution of maxillofacial brown tumors after parathyroidectomy in primary hyperparathyroidism.
abstract: BACKGROUND
  Brown tumor occasionally affects the facial bones. Clinically, these lesions can be mistaken for a neoplasm. Opinions are divided on the course of management of the bony lesions once parathyroidectomy has been carried out.
  
  
  METHODS
  We treated 22 patients with primary hyperparathyroidism and osteitis fibrosa cystica and observed their clinical and biochemical recovery.
  
  
  RESULTS
  Fifteen patients (68.2%) had brown tumors in mandible, and 7 (31.8%) in maxilla. After parathyroidectomy, 21 patients had normal total serum calcium values. All brown tumors presented a spontaneous progressive regression; in 18 cases, regression was total, with a mean time period of 10 months. Two patients had partial regression after nearly 2 years. Another 2 patients were lost to follow-up.
  
  
  CONCLUSIONS
  After successful parathyroid surgery, the bony lesions tended to regress spontaneously, either partially or completely. However, if the lesion is disfiguring or symptomatic, surgical excision may be indicated.
authors.affiliation: Department of Head and Neck Surgery, Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico. jaimearc@cablevision.net.mex
authors.forename: Jaime Alonso
authors.initials: JA
authors.lastname: Reséndiz-Colosia
authors.forename: Sergio Arturo
authors.initials: SA
authors.lastname: Rodríguez-Cuevas
authors.forename: Rutilio
authors.initials: R
authors.lastname: Flores-Díaz
authors.forename: Martín Hernández-San
authors.initials: MH
authors.lastname: Juan
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Gallegos-Hernández
authors.forename: Sinhué
authors.initials: S
authors.lastname: Barroso-Bravo
authors.forename: Fernando
authors.initials: F
authors.lastname: Gómez-Acosta
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000150:complications / Q000534:rehabilitation* / Q000601:surgery*; D008297:Male; D008334:Mandible / Q000473:pathology; D008437:Maxilla / Q000473:pathology; D008875:Middle Aged; D010002:Osteitis Fibrosa Cystica / Q000097:blood / Q000209:etiology / Q000534:rehabilitation*; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D010758:Phosphorus / Q000097:blood; D020127:Recovery of Function; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D010758:Phosphorus; D002118:Calcium