Multitalented E2A: a new role in lymphoid-lineage priming.
How do hematopoietic stem cells choose to be lymphocytes? In this issue of Immunity, Dias et al. (2008) uncover the requirement for E2A during lymphoid-lineage priming in the multipotent progenitor population.
Kondo
Motonari
M
Department of Immunology, Duke University Medical Center, 101 Jones Building, DUMC Box 3010, Research Drive, Durham, NC 27710, USA. motonari.kondo@duke.edu.
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D002454:Cell Differentiation; D019070:Cell Lineage; D005786:Gene Expression Regulation; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism*; D051740:Ikaros Transcription Factor / Q000378:metabolism; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism*; D054503:Lymphoid Progenitor Cells / Q000166:cytology / Q000378:metabolism*; D038041:Lymphopoiesis; D051379:Mice; D039902:Multipotent Stem Cells / Q000166:cytology / Q000378:metabolism*; D023461:Myeloid Progenitor Cells / Q000166:cytology / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism; D000099232:Proto-Oncogene Protein Spi-1
D051792:Basic Helix-Loop-Helix Proteins; D051740:Ikaros Transcription Factor; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D000099232:Proto-Oncogene Protein Spi-1; C075668:Tcf3 protein, mouse; C497238:Zfpn1a1 protein, mouse