title: Mesenchymal stem cells and cardiac repair.
abstract: Accumulating clinical and experimental evidence indicates that mesenchymal stem cells (MSCs) are promising cell types in the treatment of cardiac dysfunction. They may trigger production of reparative growth factors, replace damaged cells and create an environment that favours endogenous cardiac repair. However, identifying mechanisms which regulate the role of MSCs in cardiac repair is still at work. To achieve the maximal clinical benefits, ex vivo manipulation can further enhance MSC therapeutic potential. This review focuses on the mechanism of MSCs in cardiac repair, with emphasis on ex vivo manipulation.
authors.affiliation: Department of Cardiac Surgery, University of Rostock, Germany.
authors.forename: Catharina
authors.initials: C
authors.lastname: Nesselmann
authors.forename: Nan
authors.initials: N
authors.lastname: Ma
authors.forename: Karen
authors.initials: K
authors.lastname: Bieback
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wagner
authors.forename: Anthony
authors.initials: A
authors.lastname: Ho
authors.forename: Yrjö T
authors.initials: YT
authors.lastname: Konttinen
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Mihail E
authors.initials: ME
authors.lastname: Hinescu
authors.forename: Gustav
authors.initials: G
authors.lastname: Steinhoff
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000235:genetics; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D005109:Extracellular Matrix / Q000502:physiology; D005818:Genetic Engineering; D006331:Heart Diseases / Q000628:therapy*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D009206:Myocardium / Q000166:cytology*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D018919:Neovascularization, Physiologic
chemical_list: D019485:Bone Morphogenetic Proteins; D036341:Intercellular Signaling Peptides and Proteins