Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats.
Osthole (1), an active constituent isolated from Cnidium monnieri (L.) Cusson, has been used in the treatment of diseases for many years in clinical. The aim of this present study was to determine the effect of 1 on protein expression of PPARalpha/gamma and related target molecules such as CYP7A and DGAT protein expression in the liver of hyperlipidemic fatty liver (HFL) rats, and to investigate the possible mechanism of treating HFL.
Zhang
Yan
Y
Department of Pharmacology, Medical School of Soochow University, Suzhou, China.
Xie
Mei-Lin
ML
Xue
Jie
J
Gu
Zhen-Lun
ZL
D000818:Animals; D002790:Cholesterol 7-alpha-Hydroxylase / Q000235:genetics / Q000378:metabolism*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D051048:Diacylglycerol O-Acyltransferase / Q000235:genetics / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005234:Fatty Liver / Q000150:complications / Q000378:metabolism*; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008892:Milk; D015394:Molecular Structure; D047493:PPAR alpha / Q000378:metabolism*; D047495:PPAR gamma / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D003374:Coumarins; D000960:Hypolipidemic Agents; D047493:PPAR alpha; D047495:PPAR gamma; C532838:CYP7A1 protein, rat; D002790:Cholesterol 7-alpha-Hydroxylase; C522579:Dgat2 protein, rat; D051048:Diacylglycerol O-Acyltransferase; C046627:osthol