title: Should inspection of the laryngopharyngeal area be part of routine upper gastrointestinal endoscopy? A prospective study.
abstract: BACKGROUND
  Examination of the laryngopharyngeal area is not always performed during routine upper gastrointestinal (UGI) endoscopy although initial studies reported pathological findings in 0.9-3.5% of cases. The aim of this study was to prospectively evaluate the accuracy of screening the laryngopharyngeal area during routine UGI endoscopy, before insertion of endoscope into the oesophagus, to avoid a misinterpretation of trauma-related hyperaemia or erythema as signs of laryngitis.
  
  
  METHODS
  The study included 1297 patients undergoing elective UGI endoscopy, asymptomatic in the laryngopharyngeal area, who underwent a carefully structured examination of the laryngopharyngeal area, videotaped for later blinded review. If pathological findings were suspected, patients were referred to otorhinolaryngologists for additional evaluation. In all cases the DVDs were reviewed by two ear, nose, and throat (ENT) specialists blinded to the endoscopic findings.
  
  
  RESULTS
  In 1130 (87.12%) patients the examination was performed successfully before insertion of the endoscope into the oesophagus. Gastro-oesophageal reflux disease (GORD) symptoms were present in 254 (22.5%) patients, and erosive oesophagitis was documented in 89 (7.9%) patients. In 44 (3.89%) patients the pathology was suspected by the endoscopist and confirmed by the otorhinolaryngologists. Moreover, 8 (0.71%) patients were found to have laryngeal pathology in the DVDs reviewed by the ENT specialists, further confirmed by laryngoscopy. Sensitivity, specificity, positive, and negative predictive values were 84.61%, 100%, 100%, and 99.26%, respectively, for detecting laryngeal abnormalities by the endoscopist. The most important findings were leukoplakia (n=4), posterior laryngitis (n=16), Reinke's oedema (n=2), and hyperkeratosis of arytenoid folds (n=2). A strict correlation emerged between GORD and posterior laryngitis (75%) and between GORD and Reinke's oedema (100%), documented by pHmetry. A significant association was also observed between heavy smoking and leukoplakia (75%), and hypertrophy of pharyngeal tonsils (100%), respectively. All other findings were lesions without clinical significance.
  
  
  CONCLUSIONS
  Screening examination of the laryngopharyngeal area should be part of each UGI endoscopy revealing important laryngeal pathology.
authors.affiliation: Department of Endoscopy and Motility Unit, Central Hospital, Thessaloniki, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Katsinelos
authors.forename: J
authors.initials: J
authors.lastname: Kountouras
authors.forename: G
authors.initials: G
authors.lastname: Chatzimavroudis
authors.forename: C
authors.initials: C
authors.lastname: Zavos
authors.forename: A
authors.initials: A
authors.lastname: Beltsis
authors.forename: G
authors.initials: G
authors.lastname: Paroutoglou
authors.forename: N
authors.initials: N
authors.lastname: Kamarianis
authors.forename: A
authors.initials: A
authors.lastname: Pournaras
authors.forename: I
authors.initials: I
authors.lastname: Pilpilidis
mesh_terms: D000328:Adult; D000368:Aged; D003951:Diagnostic Errors / Q000517:prevention & control*; D016145:Endoscopy, Digestive System / Q000009:adverse effects / Q000379:methods*; D004942:Esophagitis, Peptic / Q000175:diagnosis*; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000175:diagnosis; D007013:Hypopharynx / Q000293:injuries / Q000473:pathology; D007827:Laryngitis / Q000175:diagnosis; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results