title: Scaffold-hopping cascade yields potent inhibitors of 5-lipoxygenase.
authors.affiliation: Institute of Organic Chemistry and Chemical Biology, ZAFES/CMP, Johann Wolfgang Goethe-University, Siesmayerstr. 70, 60323 Frankfurt am Main, Germany.
authors.forename: Bettina
authors.initials: B
authors.lastname: Hofmann
authors.forename: Lutz
authors.initials: L
authors.lastname: Franke
authors.forename: Ewgenij
authors.initials: E
authors.lastname: Proschak
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Tanrikulu
authors.forename: Petra
authors.initials: P
authors.lastname: Schneider
authors.forename: Dieter
authors.initials: D
authors.lastname: Steinhilber
authors.forename: Gisbert
authors.initials: G
authors.lastname: Schneider
mesh_terms: D018927:Anti-Asthmatic Agents / Q000737:chemistry* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D002478:Cells, Cultured; D015195:Drug Design; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D007093:Imidazoles; D016859:Lipoxygenase Inhibitors