title: Functional capacity assessment in children and adolescents with post-infectious bronchiolitis obliterans.
abstract: OBJECTIVE
  To assess functional capacity during exercise in children and adolescents with post-infectious bronchiolitis obliterans (PIBO).
  
  
  METHODS
  20 children with PIBO, aged 8-16 years old, and in follow-up at an outpatient clinic carried out cardiopulmonary exercise testing (CPET), a 6-minute walk test (6MWT) and pulmonary function tests (PFT), according to American Thoracic Society (ATS), European Respiratory Society (ERS) and American College of Chest Physicians (ACCP) guidelines. Results were expressed as percentages of predicted reference values: Armstrong's for CPET, Geiger's for 6MWT, Knudson's for spirometry, and Zapletal's for plethysmography.
  
  
  RESULTS
  Mean age (+/- SD) was 11.4+/-2.2 years; 70% were boys; mean weight: 36.8+/-12.3 kg; mean height: 143.8+/-15.2 cm. When compared to reference values, PFT detected lower airflows (spirometry) and higher volumes (plethysmography). Eleven patients had reduced peak VO2 values in CPET (< 84% predicted). The mean distance walked (6MWT) was 77.0+/-15.7% of predicted (512+/-102 m). Peak VO2 was not correlated with 6MWT, but it was correlated with FVC (L) (r = 0.90/p = 0.00), with FEV1 (L) (r = 0.86/p = 0.00) and with RV/TLC, both in absolute values (r = -0.71/p = 0.02) and as percentages of predicted values (r = -0.63/p = 0.00).
  
  
  CONCLUSIONS
  The majority of these post-infectious bronchiolitis obliterans patients exhibited reduced functional capacity, exhibited during both CPET and the 6MWT. Due to its greater feasibility, 6MWT could be an alternative where CPET is not available.
authors.affiliation: Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. rimattiello@hotmail.com
authors.forename: Rita
authors.initials: R
authors.lastname: Mattiello
authors.forename: Edgar E
authors.initials: EE
authors.lastname: Sarria
authors.forename: Ricardo
authors.initials: R
authors.lastname: Stein
authors.forename: Gilberto Bueno
authors.initials: GB
authors.lastname: Fischer
authors.forename: Helena Teresinha
authors.initials: HT
authors.lastname: Mocelin
authors.forename: Sergio Saldanha Menna
authors.initials: SS
authors.lastname: Barreto
authors.forename: João Antônio Bonfadini
authors.initials: JA
authors.lastname: Lima
authors.forename: Diego
authors.initials: D
authors.lastname: Brandenburg
mesh_terms: D000293:Adolescent; D000554:Ambulatory Care Facilities; D001989:Bronchiolitis Obliterans / Q000503:physiopathology*; D002648:Child; D002908:Chronic Disease; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D010101:Oxygen Consumption; D012129:Respiratory Function Tests; D013147:Spirometry; D016138:Walking / Q000502:physiology