Liver injury due to 3-amino-1-methyl-5h-pyrido [4,3-b] indole (Trp-P-2) and its prevention by miso.
Trp-P-2(3-amino-1-methyl-5H-pyrido [4,3-b] indole) ingestion for 42 d by C3H/HeJJcl mice caused elevation of serum alanine transaminase (ALT) activity and several signs of liver injury. These alterations were not observed in mice fed the diet supplemented with 10% miso. This suggests a preventive effect of miso as to Trp-P-2 induced liver injury.
Suzuki
Hiroyuki
H
Department of Human Life and Environmental Science, Niigata Women's College, Japan. h-suzuki@mishima.ac.jp
Sone
Hideyuki
H
Kawamura
Ken
K
Ishihara
Kazuo
K
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002243:Carbolines / Q000633:toxicity*; D008099:Liver / Q000293:injuries*; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D045730:Soy Foods
D002243:Carbolines; C019133:3-amino-1-methyl-5H-pyrido(4,3-b)indole