title: Edwards syndrome with double trisomy.
abstract: Double trisomy is rare and the only case reported in the literature died soon after birth. We present another case of double trisomy (48XYY, +18) in a male neonate, who was born to a 28-year-old gravida three parity one mother at 35 weeks of gestation. The baby had features of trisomy 18. Karyotype of the patient showed 48, XYY, +18, Ish (DYZ3*2), (D18Z1*3), nuc ish (DYZ3*2), (D18Z1*3) . The patient had clinical features of trisomy 18. There was no family history of diabetes mellitus and no exposure to chemicals. It has been suggested that the rarity of Y-chromosome involvement in trisomy 18 may be due to discrepancy between the sexes.
authors.affiliation: Neonatal Intensive Care Unit, The Townsville Hospital, Douglas, QLD 4814, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Tennakoon
authors.forename: Y
authors.initials: Y
authors.lastname: Kandasamy
authors.forename: G
authors.initials: G
authors.lastname: Alcock
authors.forename: T H
authors.initials: TH
authors.lastname: Koh
mesh_terms: D002869:Chromosome Aberrations; D002887:Chromosomes, Human, Pair 18; D041322:Chromosomes, Human, Y; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D013577:Syndrome; D014314:Trisomy