title: Urodynamic characterization of obese women with urinary incontinence undergoing a weight loss program: the Program to Reduce Incontinence by Diet and Exercise (PRIDE) trial.
abstract: The purpose of this study was to describe urodynamic characteristics of overweight or obese women with urinary incontinence and explore the relationship between urodynamic parameters, body mass index (BMI), and abdominal circumference (AC). One hundred ten women underwent a standardized cough stress test and urodynamic study. Eighty-six percent of women had urodynamic stress incontinence and 15% detrusor overactivity. Intra-abdominal pressure (Pabd) at maximum cystometric capacity (MCC) increased 0.4 cm H(2)O per kg/m(2) unit of BMI (95% confidence interval [CI] = 0.0,0.7, p = 0.04) and 0.4 cm H(2)O per 2 cm increase in AC (CI = 0.2, 0.7, p < 0.01). Intravesical pressure (Pves) at MCC increased 0.4 cm H(2)O per 2 cm increase in AC (CI = 0.0, 0.8, p = 0.05) but was not associated with BMI (p = 0.18). BMI and AC had a stronger association with Pabd than with Pves, suggesting a possible mechanism for the association between obesity and urinary incontinence.
authors.affiliation: Women's Pelvic Medicine and Reconstructive Surgery, University of Alabama at Birmingham, 618 20th Street South, NHB 219, Birmingham, AL, 35233-7333, USA. hrichter@uabmc.edu
authors.forename: Holly E
authors.initials: HE
authors.lastname: Richter
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Creasman
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Myers
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Wheeler
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Burgio
authors.forename: Leslee L
authors.initials: LL
authors.lastname: Subak
mesh_terms: D000368:Aged; D015992:Body Mass Index; D015897:Comorbidity; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology* / Q000503:physiopathology* / Q000628:therapy; D014549:Urinary Incontinence / Q000453:epidemiology* / Q000503:physiopathology* / Q000517:prevention & control; D014563:Urodynamics; D055105:Waist Circumference / Q000502:physiology; D015431:Weight Loss