Carcinogenic effect of an antitumor drug etoposide in laboratory animals.
Intravenous injection of antitumor drug etoposide in the maximum tolerated dose was followed by the development of breast cancer in 38.1% female Wistar rats and 6.7% female outbred mice.
Fomina
T I
TI
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences. toxicology_lab@mail.ru
Perelmuter
V M
VM
Vtorushin
S V
SV
Zavjalova
M V
MV
Borovskaja
T G
TG
Timina
E A
EA
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D001943:Breast Neoplasms / Q000139:chemically induced / Q000473:pathology*; D005047:Etoposide / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D007275:Injections, Intravenous; D051379:Mice; D051381:Rats; D017208:Rats, Wistar
D000970:Antineoplastic Agents; D005047:Etoposide