Apoptosis in atherosclerosis: a mini-review.
Apoptosis in atherosclerotic lesions is triggered by inflammatory processes, both via cell-cell contact and by cytokines and oxidized lipids. The role of apoptosis in atherogenesis is dual, depending on the stage of the plaque: In early stages, apoptotic death of smooth muscle--and inflammatory cells, such as lymphocytes and macrophages--may delay atherosclerotic process. However, once the plaque is formed, apoptosis may lead to plaque rupture and thrombosis.
Karaflou
Maria
M
2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, 27 Themistokleous Street, Dionysos, Athens, Greece. ilambrinoudaki@hotmail.com
Lambrinoudaki
Irene
I
Christodoulakos
George
G
D000818:Animals; D017209:Apoptosis; D050197:Atherosclerosis / Q000276:immunology / Q000473:pathology*; D002450:Cell Communication; D002467:Cell Nucleus / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D008264:Macrophages / Q000378:metabolism; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism; D017382:Reactive Oxygen Species; D013927:Thrombosis / Q000378:metabolism
D016207:Cytokines; D008055:Lipids; D017382:Reactive Oxygen Species; D010100:Oxygen