title: Recurrence of intrahepatic cholangiocarcinoma nine years after surgical resection.
abstract: This paper reports a rare case of intrahepatic cholangiocarcinoma (ICC) which recurred nine years after surgical resection. The patient underwent right hepatic trisegmentectomy with lymph node dissection and biliary tract reconstruction for a tumor in the right lobe of the liver. The patient was diagnosed with ICC, intraductal growth (IG) type. Nine years after the operation a rise of tumor markers and a recurrent lesion in the remnant liver were recognized and the patient underwent S2 subsegmentectomy with tumor thrombectomy and biliary tract reconstruction. The resected specimen showed well differentiated adenocarcinoma, which consisted of chiefly intraductal growth component. The patient is still alive 26 months after the second operation without recurrence. It is important to observe the patient carefully cosidering that it is possible for an IG type cholangiocarcinoma to recur a long time after surgical treatment, and surgical treatment for the recurrent tumor should be tried for long survival.
authors.affiliation: Department of Surgery and Medical Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. kitagawa@surg2.med.kyushu-u.ac.jp
authors.forename: Dai
authors.initials: D
authors.lastname: Kitagawa
authors.forename: Akinobu
authors.initials: A
authors.lastname: Taketomi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Aishima
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Gion
authors.forename: Ken
authors.initials: K
authors.lastname: Shirabe
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Shimada
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood; D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology / Q000601:surgery*; D014408:Biomarkers, Tumor / Q000097:blood; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D008111:Liver Function Tests; D008197:Lymph Node Excision; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D012086:Reoperation; D014057:Tomography, X-Ray Computed
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C042317:DU-PAN-2 antigen, human; C059729:pancreatic associated antigen, SPan-1