Meta- and para-difunctionalization of arenes via a sulfoxide-magnesium exchange reaction.
The aryl sulfoxide moiety (ArSO) allows an expedient two-step meta-, para-difunctionalization of readily available diaryl sulfoxides. In the first step, the sulfoxide plays the role of a directing metalation group. In the second step, triggered by i-PrMgCl x LiCl, it becomes a leaving group and undergoes a regioselective sulfoxide-magnesium exchange.
Rauhut
Christian B
CB
Department Chemie und Biochemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377, München, Germany.
Melzig
Laurin
L
Knochel
Paul
P