Synthesis of 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-hepatitis C virus (HCV) agents.
On the basis of potent anti-hepatitis C virus (HCV) activity of 2'-C-hydroxymethyladenosine, 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-HCV agents were designed and synthesized from D-xylose via stereoselective Grignard reaction and conversion of the vinyl into hydroxymethyl group as key steps.
Pei
Xiaojuan
X
Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul, Korea.
Choi
Won Jun
WJ
Kim
Yu Min
YM
Zhao
Long Xuan
LX
Jeong
Lak Shin
LS
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D016174:Hepacivirus / Q000187:drug effects*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*
D000998:Antiviral Agents; D007202:Indicators and Reagents; D011684:Purine Nucleosides; D011741:Pyrimidine Nucleosides