New insights into the mechanism of precursor protein insertion into the mitochondrial membranes.
Mitochondria are surrounded by a double membrane system that forms four intra-organelle compartments: the outer membrane, inner membrane, intermembrane space, and matrix. Each of the two membranes contains a unique set of proteins defining specific functions of that membrane. The vast majority of mitochondrial proteins including those of the mitochondrial membranes are nuclear encoded and synthesized as precursor proteins in the cytosol. Subsequently, they are targeted to the mitochondria and become sorted to the correct submitochondrial destination. A small portion of the mitochondrial inner membrane proteins is encoded by the mitochondrial genome. These proteins are synthesized on mitochondrial ribosomes and are inserted by dedicated machinery into the inner membrane. This chapter summarizes our current knowledge of the signals that target mitochondrial membrane proteins to their correct intracellular location, and describes the mechanisms by which mitochondrial translocation machineries recognize precursor proteins and mediate their insertion into mitochondrial membranes.
Hildenbeutel
Markus
M
Cell Biology, University of Kaiserslautern, 67663 Kaiserslautern, Germany.
Habib
Shukry J
SJ
Herrmann
Johannes M
JM
Rapaport
Doron
D
D033681:Mitochondrial Membrane Transport Proteins / Q000737:chemistry / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D008958:Models, Molecular; D046912:Multiprotein Complexes; D011498:Protein Precursors / Q000737:chemistry / Q000378:metabolism*; D021381:Protein Transport; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism
D033681:Mitochondrial Membrane Transport Proteins; D024101:Mitochondrial Proteins; D046912:Multiprotein Complexes; D011498:Protein Precursors; D029701:Saccharomyces cerevisiae Proteins