title: [Effectiveness of oral osmotic-methylphenidate in treatment of attention deficit hyperactivity disorder in children].
abstract: OBJECTIVE
  Methylphenidate is recommended as a first-line modality for treating attention deficit hyperactivity disorder (ADHD). In the past, immediate release methylphenidate (IR-MPH) was used for ADHD. Now oral osmotic-methylphenidate (OROS-MPH) is used for ADHD in China. This study was designed to investigate the efficacy and safety of OROS-MPH for treatment of ADHD in children.
  
  
  METHODS
  Ninety-nine children with ADHD were randomly administered with OROS-MPH (18 mg/time, once daily) and IR-MPH (5 mg/ time, twice or three times per day). After 6 weeks of treatment, the therapeutic effects were evaluated by the SNAP-IV and the IVA-CPT.
  
  
  RESULTS
  Fifty patients completed the 6-week treatment. The effective rate (83.3% vs 75%) and the complete remission rate (44% vs 25%) in the OROS-MPH treatment group were higher than that in the IR-MPH treatment group. There were statistically significant differences in the SNAP-IV and IVA-CPT scores before and after treatment in the two groups (P<0.01). The two groups had a similar incidence of side effects during treatment.
  
  
  CONCLUSIONS
  OROS-MPH for the treatment of ADHD is effective and safe in children, and its once-daily administration is more convenient.
authors.affiliation: Department of Developmental Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China.
authors.forename: Xue-Xia
authors.initials: XX
authors.lastname: Pan
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Ma
authors.forename: Bin
authors.initials: B
authors.lastname: Wan
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Dai
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D008774:Methylphenidate