title: Intravenous immunoglobulin therapy in dermatologic disorders.
abstract: Intravenous immunoglobulin (IVIG) is sterilized and purified human plasma which contains supra-physiologic levels of immunoglobulin G. IVIG is currently used in the treatment of immunodeficiency syndromes, inflammatory disorders and infectious diseases. Although numerous immunomodulatory mechanisms have been suggested, the exact mechanisms of action are poorly understood. There is also accumulating evidence that high-dose IVIG is efficacious in the treatment of some skin diseases, despite the lack of evidence from randomized, double-blind, placebo-controlled trials. Though in most cases, IVIG is only effective in combination with other immunomodulating strategies, it offers new hope for the treatment of many severe dermatologic conditions. This article focuses on the efficacy and safety of IVIG therapy in skin diseases.
authors.affiliation: Turan Güneş Bulvari 71, Sokak 18/8 Yildiz, Cankaya, Ankara, Turkey. seraycakmak@yahoo.com
authors.forename: Seray Külcü
authors.initials: SK
authors.lastname: Cakmak
authors.forename: Ulker
authors.initials: U
authors.lastname: Gül
authors.forename: Müzeyyen
authors.initials: M
authors.lastname: Gönül
authors.forename: Arzu
authors.initials: A
authors.lastname: Kiliç
authors.forename: Seçil
authors.initials: S
authors.lastname: Soylu
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D004333:Drug Administration Routes; D006801:Humans; D007116:Immunization, Passive; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D012871:Skin Diseases / Q000276:immunology* / Q000628:therapy*
chemical_list: D016756:Immunoglobulins, Intravenous