A novel cell subset: interferon-producing killer dendritic cells.
Recent reports introduce a novel cell subset of DCs with antigenic phenotypes shared by both NK cells and B cells, but without surface markers of pDCs and T cells, appearing to be a chimera of NK cells and DCs, namely interferon-producing killer dendritic cells (IKDCs). IKDCs not only secret type I and type II interferons to recognize and kill tumor cells effectively, but also express MHC-II molecules to present antigens. Thus, IKDCs are considered as important immunosurveilance cells for tumors, providing a link between innate and adaptive immunity.
Wang
Jiongkun
J
Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China.
Xing
Feiyue
F
D000818:Animals; D048430:Cell Shape; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D005802:Genes, MHC Class II; D006801:Humans; D007372:Interferons / Q000276:immunology*; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype
D007372:Interferons