Insulin-related metabolism following hematopoietic stem cell transplantation in childhood.
OBJECTIVE
To assess insulin-related metabolism following hematopoietic stem cell transplantation (HSCT) in childhood.


METHODS
Thirty-four patients who underwent HSCT were compared with 21 patients with similar diseases who were not transplanted. Median follow-up was 3.6 yr after HSCT. Anthropometric parameters, fasting plasma glucose and insulin levels, hemoglobin A(1c) (HbA(1c)) and lipid profile were measured and compared.


RESULTS
HbA(1c) was significantly higher (p = 0.001) in the study group. Two (5.8%) patients in the study group developed type 2 diabetes mellitus. Among thalassemic patients, significantly lower insulin resistance indices (p = 0.05) and fasting plasma insulin levels (p = 0.033) were found in the study group compared with the control group.


CONCLUSIONS
Attentive follow-up of insulin-related metabolism following HSCT in children is needed. The significance of the higher HbA1c values in the study group remains to be evaluated in a larger cohort of patients.
Elhasid
Ronit
R
Department of Pediatric Hemato-Oncology, Rambam Health Care Campus, Haifa, Israel. r_elhasid@rambam.health.gov.il
Leshem
Yael A
YA
Ben Arush
Myriam Weyl
MW
Rowe
Jacob M
JM
Shehadeh
Naim
N
D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008297:Male; D019172:Transplantation Conditioning / Q000009:adverse effects*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D055815:Young Adult
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; C517652:hemoglobin A1c protein, human