title: Antifungal resistance mechanisms of Aspergillus.
abstract: The incidence of invasive aspergillosis (IA) , which is commonly caused by Aspergillus fumigatus, has increased recently in immunocompromised patients and has become the common cause of death in these patients. Antifungal resistance is one of the reasons for treatment failure. Since the first itraconazole-resistant A. fumigatus was reported in 1997, the reports on clinical strains of triazole-resistant A. fumigatus have increased, as well as studies on the resistant mechanisms. In this paper, the known molecular mechanisms of antifungal resistance in Aspergillus, especially in A. fumigatus, are reviewed.
authors.affiliation: Peking University First Hospital, Research Center for Medical Mycology, Peking University, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Qiao
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Ruoyu
authors.initials: R
authors.lastname: Li
mesh_terms: D001232:Aspergillus fumigatus / Q000187:drug effects*; D025141:Drug Resistance, Fungal; D014230:Triazoles / Q000494:pharmacology
chemical_list: D014230:Triazoles