[Effects of 5-fluorouracil on tendon adhesion formation after flexor tendon repair].
OBJECTIVE
To evaluate the effect of 5-fluorouracil (5-FU) applied topically on preventing adhesion and promoting functional recovery after tendon repair.


METHODS
From August 2003 to June 2007, 48 patients with flexor tendon rupture of the fingers by sharp instrument were treated and randomly divided into two groups. In 5-FU group, 39 fingers of 26 patients included 17 males and 9 females, aged (29.3 +/- 9.8) years; the locations were zone I in 19 fingers and zone II in 20 fingers; single finger was involved in 12 cases and more than 2 fingers were involved in 14 cases; and the time from injury to operation was (2.4 +/- 1.6) hours. In control group, 36 fingers of 22 patients included 14 males and 8 females; aged (26.1 +/- 8.7) years; the locations were zone I in 16 fingers and zone II in 20 fingers; single finger was involved in 10 cases and more than 2 fingers were involved in 12 cases; and the time from injury to operation was (2.1 +/- 1.8) hours. No statistically significant difference was found in constituent ratio of age, gender, injured fingers and their zones, between two groups (P > 0.05). The repair site in 5-FU group was given 5-FU at a concentration of 25 mg/mL with a soaked sponge, and the synovial sheath of the repaired site was wrapped with the 5-FU-soaked sponge for 1 minute for 4 times after the tendons were repaired; normal saline was used in the control group.


RESULTS
Wound healed by first intention and no infection and tendon rupture occurred in two groups. The patients were followed up for 3-8 months (mean 4.1 months) and 3-8 months (mean 3.9 months) in 5-FU group and in control group respectively. The functional recovery degrees of the fingers were evaluated with total active movement (TAM) evaluation system. In 5-FU group, the results were excellent in 22 fingers, good in 13 fingers, fair in 3 fingers and poor in 1 finger; the excellent and good rate was 89.7%. In control group, the results were excellent in 11 fingers, good in 15 fingers, fair in 9 fingers and poor in 1 finger; the excellent and good rate was 72.2%. There was statistically significant difference in the functional recovery degrees of fingers between two groups (P < 0.05). The 2 fingers which had a poor result in 5-FU group and control group were served with tenolysis was performed in 2 cases having poor results after 6 months of operation and had an excellent result at last.


CONCLUSIONS
5-FU applied topically can reduce tendon adhesions after the ruptured tendon repair.
Guo
Mingke
M
Department of Orthopedics, the 260th Hospital of PLA, Shijiazhuang Hebei, 050041, PR China.
Zhang
Jingqi
J
Tian
Dehu
D
Zhang
Yingze
Y
Peng
Xiuqing
X
Wang
Zhou
Z
Wu
Jun
J
Duan
Yafei
Y
Dou
Zhip
Z
Wang
Cuihua
C
D000328:Adult; D005260:Female; D005383:Finger Injuries / Q000601:surgery*; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D019651:Plastic Surgery Procedures / Q000379:methods; D013708:Tendon Injuries / Q000601:surgery*; D013710:Tendons / Q000473:pathology / Q000601:surgery; D000267:Tissue Adhesions / Q000517:prevention & control*; D014945:Wound Healing
D005472:Fluorouracil