title: Recent research on changes in genomic regulation and protein expression in intracerebral haemorrhage.
abstract: Intracerebral haemorrhage (ICH) is a devastating form of stroke that accounts for roughly 10% of all strokes and the effects on those that survive are often debilitating. To date, no suitable therapy exists. Recent work has examined alterations in gene and protein expression after ICH. The focus of this review is to outline the current knowledge of changes in genetic and protein expression after ICH and how those changes may affect the course of brain injury. Both animal and human data are reviewed.
authors.affiliation: Department of Neurology, Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15260, USA. cannonjr@upmc.edu
authors.forename: Jason R
authors.initials: JR
authors.lastname: Cannon
authors.forename: Guohua
authors.initials: G
authors.lastname: Xi
authors.forename: Richard F
authors.initials: RF
authors.lastname: Keep
mesh_terms: D000818:Animals; D001925:Brain Damage, Chronic / Q000209:etiology / Q000235:genetics; D002543:Cerebral Hemorrhage / Q000150:complications / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D004195:Disease Models, Animal; D004790:Enzyme Induction; D005544:Forecasting; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006360:Heat-Shock Proteins / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007473:Ion Channels / Q000096:biosynthesis / Q000235:genetics; D051379:Mice; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics*; D018377:Neurotransmitter Agents / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D013312:Stress, Physiological / Q000209:etiology / Q000235:genetics
chemical_list: D006360:Heat-Shock Proteins; D007473:Ion Channels; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents