Comparative genome hybridization array analysis for sporadic Parkinson's disease.
Parkinson disease (PD) is a common neurodegenerative disorder, characterized by the loss of midbrain dopamine neurons and Lewy body inclusions. We investigated array CGH to analyze gain or loss of genetic material from 30 patients with PD. We identified the frequent copy number variations in PD; gains in 1p21.1, 4p15.31, 5p15.33, 6q24.1, 7q35, 8q24.3, 10q26.3, 11p15.5-15.4, 12q21.2, 16p13.3, 18q12.3 and 22q13.31, and losses in 1p36.33, and 5q13.2. These findings enable a better description of genetic variations in PD, and could provide a foundation for understanding the critical regions of the genome that may be involved in the development of PD.
Kim
Joong-Seok
JS
Department of Neurology, The Catholic University of Korea, Seoul, Republic of Korea. neuronet@catholic.ac.kr
Yoo
Ji-Yeon
JY
Lee
Kwang-Soo
KS
Kim
Hye Sung
HS
Choi
Jin Soo
JS
Rha
Hyoung Kyun
HK
Yim
Sung-Vin
SV
Lee
Kweon-Haeng
KH
D000368:Aged; D000369:Aged, 80 and over; D002874:Chromosome Mapping / Q000379:methods*; D055028:Comparative Genomic Hybridization / Q000379:methods; D005260:Female; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics*