Oxidative and antioxidant changes during formation of unstable atherosclerotic plaque.
Oxidative and antioxidant parameters (content of LPO products and oxidized proteins, initial level of paraoxonase, content of alpha-tocopherol, retinol, and beta-carotene) were studied at different stages of atherosclerotic foci development in coronary arteries: intact intima, lipid spot, stable young plaque, unstable plaque, stable plaque with fibrosis/ calcinosis, and in various types of unstable plaques. The most typical sign of unstable plaques is high level of LPO products and low retinol content.
Ragino
Yu I
YI
Institute of Therapy, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. ragino@online.nsk.su
Chernyavski
A M
AM
Polonskaya
Ya V
YV
Volkov
A M
AM
Semaeva
E V
EV
Voevoda
M I
MI
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000378:metabolism; D050197:Atherosclerosis / Q000378:metabolism* / Q000473:pathology; D003331:Coronary Vessels / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D016877:Oxidants / Q000378:metabolism*; D010084:Oxidation-Reduction; D013050:Spectrometry, Fluorescence; D014801:Vitamin A / Q000378:metabolism; D024502:alpha-Tocopherol / Q000378:metabolism; D019207:beta Carotene / Q000378:metabolism
D000975:Antioxidants; D016877:Oxidants; D019207:beta Carotene; D014801:Vitamin A; D008315:Malondialdehyde; D043303:Aryldialkylphosphatase; D024502:alpha-Tocopherol