Circulating CD34-positive cells have prognostic value for neurologic function in patients with past cerebral infarction.
Increasing evidence points to a role for circulating endothelial progenitors, including populations of CD34-positive (CD34(+)) cells present in peripheral blood, in vascular homeostasis and neovascularization. In this report, circulating CD34(+) cells in individuals with a history of cerebral infarction were correlated with changes in neurologic function over a period of 1 year. Patients with decreased levels of CD34(+) cells displayed significant worsening in neurologic function, evaluated by the Barthel Index and Clinical Dementia Rating. These results support the hypothesis that levels of circulating CD34(+) cells have prognostic value for neural function, consistent with their potential role in maintaining cerebral circulation.
Taguchi
Akihiko
A
Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan. taguchi@ri.ncvc.go.jp
Nakagomi
Nami
N
Matsuyama
Tomohiro
T
Kikuchi-Taura
Akie
A
Yoshikawa
Hiroo
H
Kasahara
Yukiko
Y
Hirose
Haruka
H
Moriwaki
Hiroshi
H
Nakagomi
Takayuki
T
Soma
Toshihiro
T
Stern
David M
DM
Naritomi
Hiroaki
H
D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism*; D002465:Cell Movement; D002490:Central Nervous System / Q000166:cytology* / Q000378:metabolism*; D002544:Cerebral Infarction / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011379:Prognosis
D018952:Antigens, CD34