Tubuloreticular structures in different types of myositis: implications for pathogenesis.
In dermatomyositis (DM) there is strong histopathological evidence of a microvascular pathogenesis, including endothelial microtubular inclusions. In nonspecific myositis, perimysial and perivascular infiltrates in the muscle biopsy similar to DM are found. Microtubular inclusions in endothelial cells were systematically searched for and found in 4 of the 20 muscle biopsies of nonspecific myositis patients (20%). Three had a CTD (SLE, scleroderma, and Sjogren syndrome). Ten patients with DM and 5 patients with sporadic inclusion body myositis served as positive and negative controls, respectively.
Bronner
Irene M
IM
Department of Neurology, Flevoziekenhuis, Almere, The Netherlands.
Hoogendijk
Jessica E
JE
Veldman
Henk
H
Ramkema
Marja
M
van den Bergh Weerman
Marius A
MA
Rozemuller
Annemieke J M
AJ
de Visser
Marianne
M
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000473:pathology; D001706:Biopsy; D002196:Capillaries / Q000648:ultrastructure; D003882:Dermatomyositis / Q000473:pathology*; D004730:Endothelium, Vascular / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008179:Lupus Erythematosus, Discoid / Q000473:pathology; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008870:Microtubules / Q000648:ultrastructure*; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000473:pathology; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000473:pathology; D012595:Scleroderma, Systemic / Q000473:pathology; D012859:Sjogren's Syndrome / Q000473:pathology