In situ quantitative measurement of concentration profiles in a microreactor with submicron resolution using multiplex CARS microscopy.
In situ quantitative imaging of concentration profiles of reactants and products inside a microfluidic reactor is achieved, with submicron spatial resolution with mM sensitivity and on ms time scales, for a given position. The label-free approach relies on quantitative vibrational spectroscopy, using Coherent Anti-Stokes Raman scattering microscopy in a spectrally resolved fashion, and is demonstrated on an elementary acid-base reaction.
Schafer
Dawn
D
Department of Physics, Colorado School of Mines, 1523 Illinois Street, Golden, Colorado 80401, USA.
Squier
Jeff A
JA
van Maarseveen
Jan
J
Bonn
Daniel
D
Bonn
Mischa
M
Müller
Michiel
M
D019342:Acetic Acid / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D011759:Pyrrolidines / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods*
D011759:Pyrrolidines; C032519:pyrrolidine; D019342:Acetic Acid