Cerebral amyloid angiopathy-related hemorrhages.
Cerebral amyloid angiopathy (CAA) is defined by the accumulation of amyloid in the walls of small-and medium-sized cerebral arteries. One of the most recognized complications of CAA is spontaneous, often recurrent, intracerebral hemorrhage, usually involving the cortex and/or subcortical white matter ("lobar hemorrhage"). Several useful animal and in vitro models as well as specific neuroimaging techniques have been recently developed, which are expected to provide detailed insight into the pathogenesis of CAA and contribute to the development of targeted antiamyloid therapies.
Pezzini
Alessandro
A
Dipartimento di Scienze Mediche e Chirurgiche, Clinica Neurologica Università degli Studi di Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy. ale_pezzini@hotmail.com
Padovani
Alessandro
A
D000367:Age Factors; D000368:Aged; D000375:Aging / Q000378:metabolism / Q000473:pathology; D000682:Amyloid / Q000378:metabolism; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D002536:Cerebral Arteries / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism; D017510:Protein Folding
D000682:Amyloid; D009419:Nerve Tissue Proteins