Intracytoplasmic sperm injection (ICSI) using cryopreserved sperm from men with malignant neoplasm yields high pregnancy rates.
OBJECTIVE
To investigate the efficacy of IVF-intracytoplasmic sperm injection (ICSI) in patients who cryobanked semen before cancer treatment.


METHODS
Retrospective consecutive study.


METHODS
University-based IVF unit.


METHODS
One hundred eighteen couples undergoing IVF-ICSI using pretreatment frozen sperm.


METHODS
Treatment follow-up.


METHODS
Semen parameters and clinical pregnancy rates.


RESULTS
One hundred eighteen couples underwent 169 IVF cycles using pretreatment cryopreserved sperm; the average sperm count was 66.5 x 10(6)/mL, and the average motility was 45.6%. Post-thaw sperm average density was 40.9 x 10(6)/mL with 14.2% motility. The clinical pregnancy rate was 56.8% per retrieval; 96 pregnancies were achieved, resulting in 126 children born and 11 spontaneous abortions. Patients with prostate cancer had the worst semen parameters before sperm banking and the lowest clinical pregnancy rates.


CONCLUSIONS
IVF-ICSI is the recommended treatment for most couples with cryopreserved sperm for male cancer. High pregnancy and delivery rates after IVF-ICSI using cryopreserved sperm from patients with cancer should encourage all reproductive-age males to cryobank semen immediately after diagnosis; physicians should discuss this and advise freezing multiple samples before treatment.
Hourvitz
Ariel
A
IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Goldschlag
Dan E
DE
Davis
Owen K
OK
Gosden
Lucinda Veeck
LV
Palermo
Gianpiero D
GD
Rosenwaks
Zev
Z
D000328:Adult; D015897:Comorbidity; D015925:Cryopreservation / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007246:Infertility / Q000453:epidemiology* / Q000628:therapy*; D007557:Israel / Q000453:epidemiology; D008297:Male; D009369:Neoplasms / Q000453:epidemiology*; D011247:Pregnancy; D018873:Pregnancy Rate; D013076:Sperm Count / Q000706:statistics & numerical data*; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data*; D016896:Treatment Outcome