title: Ocular pulse amplitude in normal tension and primary open angle glaucoma.
abstract: OBJECTIVE
  (1) To investigate the relationship of ocular pulse amplitude (OPA) with intraocular pressure (IOP) and corneal thickness. (2) To evaluate OPA in patients with primary open angle and normal tension glaucoma (NTG).
  
  
  METHODS
  Patients with NTG (n=28), primary open angle glaucoma (POAG) (n=19), and age-matched healthy controls (n=22) underwent 2 consecutive Goldmann and dynamic contour tonometry measurements within 1 month. Central corneal thickness was also measured. A regression model was applied to compare OPA between the diagnostic groups.
  
  
  RESULTS
  OPA increased with rising IOP (slope 0.026/0.033 and P=0.002/<0.0001 for Goldmann/Dynamic tonometry), whereas corneal thickness did not influence pulse amplitude measurements (slope-0.0017/-0.0013 and P=0.11/0.21 after correction for Goldmann/Dynamic tonometry). In a multivariate model correcting for IOP and corneal thickness, OPA was reduced in patients with NTG (P=0.014/0.017 corrected for Goldmann/Dynamic tonometry) or POAG (P=0.015/0.014).
  
  
  CONCLUSIONS
  OPA is reduced in normal tension and POAG patients compared with healthy controls. OPA is influenced by IOP, but not by corneal thickness.
authors.affiliation: Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium. ingeborg.stalmans@uzleuven.be
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Stalmans
authors.forename: Alon
authors.initials: A
authors.lastname: Harris
authors.forename: Veerle
authors.initials: V
authors.lastname: Vanbellinghen
authors.forename: Thierry
authors.initials: T
authors.lastname: Zeyen
authors.forename: Brent
authors.initials: B
authors.lastname: Siesky
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D003315:Cornea / Q000033:anatomy & histology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D009798:Ocular Hypertension / Q000503:physiopathology; D012039:Regional Blood Flow; D014065:Tonometry, Ocular