Fusing time series expression data through hybrid aggregation and hierarchical merge.
CONCLUSIONS
A novel integration approach targeting the combination of multi-experiment time series expression data is proposed. A recursive hybrid aggregation algorithm is initially employed to extract a set of genes, which are eventually of interest for the biological phenomenon under study. Next, a hierarchical merge procedure is specifically developed for the purpose of fusing together the multiple-experiment expression pro.les of the selected genes. This employs dynamic time warping alignment techniques in order to account adequately for the potential phase shift between the different experiments. We subsequently demonstrate that the resulting gene expression pro.les consistently re.ect the behavior of the original expression pro.les in the different experiments.


BACKGROUND
Supplementary data are available athttp://www.tu-plovdiv.bg/Container/bi/DataIntegration/
Tsiporkova
Elena
E
Innovation Center, East Flanders, House of Economy, Seminariestraat and 2, B-9000 Ghent, Belgium.
Boeva
Veselka
V
D000465:Algorithms; D001426:Bacterial Proteins / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000378:metabolism; D030541:Databases, Genetic; D020869:Gene Expression Profiling / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012440:Saccharomyces / Q000166:cytology / Q000378:metabolism; D013997:Time Factors
D001426:Bacterial Proteins; D018797:Cell Cycle Proteins