The MAO-A genotype does not modulate resting brain metabolism in adults.
Variation in the monoamine-oxidase-A (MAO-A) gene has been associated with volumetric changes in corticolimbic regions with differences in their response to relevant emotional tasks. Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype.
Alia-Klein
Nelly
N
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States. nellyklein@bnl.gov
Kriplani
Aarti
A
Pradhan
Kith
K
Ma
Jim Yeming
JY
Logan
Jean
J
Williams
Benjamin
B
Craig
Ian W
IW
Telang
Frank
F
Tomasi
Dardo
D
Goldstein
Rita Z
RZ
Wang
Gene-Jack
GJ
Volkow
Nora D
ND
Fowler
Joanna S
JS
D000328:Adult; D001921:Brain / Q000033:anatomy & histology* / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D005838:Genotype; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008032:Limbic System / Q000378:metabolism; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D049268:Positron-Emission Tomography
D008995:Monoamine Oxidase; D005947:Glucose