title: Antroduodenojejunal motor activity in untreated and treated celiac disease patients.
abstract: OBJECTIVE
  Patients with celiac disease may present with abnormal upper gut motor activity. However, it is not known if these abnormalities persist after the introduction of a gluten-free diet. The present study aimed to compare antroduodenojejunal motor variables recorded in untreated celiac patients with those of celiac patients given a gluten-free diet and healthy volunteers.
  
  
  METHODS
  Eleven untreated celiac disease patients, 12 age- and sex-matched celiac patients on a gluten-free diet (at least 12 months), and 33 controls entered the study. Antroduodenojejunal motility was recorded for 6 h during fasting and for 3 h after a standard meal by means of a perfused, multiple lumen catheter.
  
  
  RESULTS
  More than 80% of untreated celiac patients had discrete motor abnormalities of the upper gut, in both fasting and fed recordings, compared to the other subjects. Patients on a gluten-free diet also showed motor abnormalities, albeit to a lesser extent. In these patients histological evaluation showed the persistence of mild mucosal abnormalities.
  
  
  CONCLUSIONS
  Upper gut motor abnormalities are frequent in patients with celiac disease, even in those on a gluten-free diet. In the latter group, these abnormalities may suggest an incomplete adherence to the dietary regimen.
authors.affiliation: Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: Gabrio
authors.initials: G
authors.lastname: Bassotti
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Villanacci
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mazzocchi
authors.forename: Marina
authors.initials: M
authors.lastname: Mariano
authors.forename: Paolo
authors.initials: P
authors.lastname: Incardona
authors.forename: Carlo
authors.initials: C
authors.lastname: Clerici
authors.forename: Antonio
authors.initials: A
authors.lastname: Morelli
mesh_terms: D000328:Adult; D000368:Aged; D002446:Celiac Disease / Q000178:diet therapy* / Q000473:pathology / Q000503:physiopathology; D018753:Diet, Protein-Restricted; D004384:Duodenoscopy; D004386:Duodenum / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D007583:Jejunum / Q000503:physiopathology*; D008297:Male; D008365:Manometry; D008875:Middle Aged; D019518:Postprandial Period; D011312:Pressure; D011706:Pyloric Antrum / Q000503:physiopathology*; D011795:Surveys and Questionnaires