title: Relevance of ineffective esophageal motility with erosive and nonerosive gastroesophageal reflux disease.
abstract: BACKGROUND
  Ineffective esophageal motility (IEM) is a frequent finding in patients with gastroesophageal reflux disease (GERD). It is responsible for delayed acid clearance as it affects esophageal emptying and saliva transport. Since erosive GERD is a more severe disease than nonerosive GERD, it may be associated with IEM, which delays esophageal clearance. Objective : We investigated the role of IEM in patients with erosive and nonerosive GERD.
  
  
  METHODS
  We enrolled 100 patients with heartburn and a primary diagnosis of GERD referred to the GI motility department of RCGLD of Shahid Beheshti University between January 2002 and January 2005. Based on endoscopic findings, the patients were classified into two groups of erosive GERD and nonerosive GERD. Manometry and 24-hour ambulatory pH-metry was performed in all patients.
  
  
  RESULTS
  Seventy-seven patients completed the study: 31 (40.3%) with erosive GERD and 46 (59.7%) with nonerosive GERD. IEM was present in 38.7% of patients with erosive GERD and in 28.3% of those with nonerosive GERD (p=0.18). A low lower esophageal sphincter pressure was present in 45.2% of patients with erosive GERD, and in 45.7% of those with nonerosive GERD (p=0.97). Abnormal acid reflux was present in 32.3% and 41.3% of patients with erosive and nonerosive GERD, respectively (p=0.42).
  
  
  CONCLUSIONS
  There was no difference in the prevalence of IEM between patients with erosive and nonerosive GERD. IEM could be an integral part of GERD and may not always be associated with mucosal injury.
authors.affiliation: Department of Gastroenterology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. swt_f@yahoo.com
authors.forename: Mojgan
authors.initials: M
authors.lastname: Foroutan
authors.forename: Hadi Mohammad
authors.initials: HM
authors.lastname: Doust
authors.forename: Behzad
authors.initials: B
authors.lastname: Jodeiri
authors.forename: Faramarz
authors.initials: F
authors.lastname: Derakhshan
authors.forename: Hamid
authors.initials: H
authors.lastname: Mohaghegh
authors.forename: Hamideh
authors.initials: H
authors.lastname: Mousapour
authors.forename: Sara
authors.initials: S
authors.lastname: Poursaadati
authors.forename: Mohammad Yaser
authors.initials: MY
authors.lastname: Kiarudi
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Zali
mesh_terms: D000328:Adult; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008297:Male