title: Left ventricular systolic and diastolic function and carotid intima-media thickness in pediatric dialysis patients.
abstract: BACKGROUND
  Cardiovascular complications are common in patients with end-stage renal disease (ESRD). We aimed to investigate left ventricular (LV) function and carotid intima-media thickness (cIMT) in children and adolescents with ESRD.
  
  
  METHODS
  This study included 38 ESRD patients (15 hemodialysis and 23 peritoneal dialysis) and 17 age- and sex-matched healthy subjects.
  
  
  RESULTS
  The ESRD patients had significantly lower mean mitral E/A ratio, and higher left ventricular mass index (LVMI) and cIMT than the control group. Compared with PD patients, HD patients had worse LV diastolic function. In stepwise linear regression analysis, LVMI (P = 0.043) and hemoglobin (P = 0.015) turned out to be independent variables for predicting diastolic dysfunction (reduced E/A ratio), and the only significant predictor of cIMT was indexed diastolic blood pressure (DBP) (P = 0.035).
  
  
  CONCLUSIONS
  Cardiovascular structure and function abnormalities are also common in pediatric dialysis patients, as in adults. Furthermore our data indicated that hemodialysis was disadvantageous for preserving LV diastolic function as compared with peritoneal dialysis.
authors.affiliation: Department of Pediatric Nephrology, Istanbul University Cerrahpasa Medical Faculty, Cerrahpasa, 34303 Istanbul, Turkey. drcivilibal@hotmail.com
authors.forename: Mahmut
authors.initials: M
authors.lastname: Civilibal
authors.forename: Huseyin
authors.initials: H
authors.lastname: Oflaz
authors.forename: Salim
authors.initials: S
authors.lastname: Caliskan
authors.forename: Cengiz
authors.initials: C
authors.lastname: Candan
authors.forename: Nur
authors.initials: N
authors.lastname: Canpolat
authors.forename: Gulseren
authors.initials: G
authors.lastname: Pehlivan
authors.forename: Lale
authors.initials: L
authors.lastname: Sever
authors.forename: Ozgur
authors.initials: O
authors.lastname: Kasapcopur
authors.forename: Nil
authors.initials: N
authors.lastname: Arisoy
mesh_terms: D000293:Adolescent; D002318:Cardiovascular Diseases / Q000209:etiology; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D006435:Renal Dialysis; D012307:Risk Factors; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000502:physiology*; D055815:Young Adult