title: Medical and surgical management of symptomatic carotid stenosis.
abstract: Carotid bifurcation stenosis is an important cause of ischaemic stroke, particularly in patients with recent transient ischaemic attack or minor stroke. Large randomized trials of endarterectomy have shown that surgery reduces the risk of stroke in patients with > or = 50% recently symptomatic carotid stenosis, and more recent research has gone some way to wards identifying which patients benefit the most. Individual risk modelling has been shown to be useful in selecting patients with the most to gain from endarterectomy for symptomatic stenosis, although timely surgery and optimal medical treatment are of equal importance.
authors.affiliation: Stroke Prevention Research Unit, University Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK. peter.rothwell@clneuro.ox.ac.uk
authors.forename: Peter M
authors.initials: PM
authors.lastname: Rothwell
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D016893:Carotid Stenosis / Q000628:therapy*; D002986:Clinical Trials as Topic; D006801:Humans; D019635:Neurosurgical Procedures; D014656:Vascular Surgical Procedures
chemical_list: D000925:Anticoagulants