title: Immunohistochemical expression of collagen type IV antibody in the articular disc of the temporomandibular joint of human fetuses.
abstract: The objective of this paper was to study the morphology of the articular disc and analyze the immunohistochemical expression of the marker of type IV collagen in the articular disc of the temporomandibular joint (TMJ) of human fetuses of different gestational ages. Twenty TMJ from human fetuses aging from 21 to 24 weeks of intrauterine life were studied. The TMJ were supplied by the Federal University of Uberaba. The ages of the fetuses were determined by measuring the crown-rump length (CRL). Macroscopically, the fetuses were fixed in a formalin solution at 10% and dissected by removing the skin and the subcutaneous tissue, exposing the deep structures. An immunohistochemical marker of type IV collagen was used in order to characterize the presence of blood vessels in the central region of the temporomandibular joint disc. Analysis of the immunohistochemical marker of type IV collagen showed the presence of blood vessels in the central region of the temporomandibular disc in human fetuses.
authors.affiliation: Disciplina de Anatomia Descritiva e Topográfica, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brasil. luisotavio27@yahoo.com.br
authors.forename: Luís Otávio Carvalho
authors.initials: LO
authors.lastname: de Moraes
authors.forename: Fábio Redivo
authors.initials: FR
authors.lastname: Lodi
authors.forename: Thiago Simão
authors.initials: TS
authors.lastname: Gomes
authors.forename: Sergio Ricardo
authors.initials: SR
authors.lastname: Marques
authors.forename: João Antão
authors.initials: JA
authors.lastname: Fernandes Junior
authors.forename: Celina Tizuko Fijiyama
authors.initials: CT
authors.lastname: Oshima
authors.forename: Luís Garcia
authors.initials: LG
authors.lastname: Alonso
mesh_terms: D000918:Antibody Specificity; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D001808:Blood Vessels / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D024141:Collagen Type IV / Q000032:analysis / Q000096:biosynthesis*; D005333:Fetus; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D018919:Neovascularization, Physiologic / Q000502:physiology*; D019224:Temporomandibular Joint Disc / Q000098:blood supply* / Q000196:embryology* / Q000378:metabolism
chemical_list: D015415:Biomarkers; D024141:Collagen Type IV