Revisiting the host as a growth medium.
The ability of the human body to play host to bacterial pathogens has been studied for more than 200 years. Successful pathogenesis relies on the ability to acquire the nutrients that are necessary for growth and survival, yet relatively little is understood about the in vivo physiology and metabolism of most human pathogens. This Review discusses how in vivo carbon sources can affect disease and highlights the concept that carbon metabolic pathways provide viable targets for antibiotic development.
Brown
Stacie A
SA
Section of Molecular Genetics and Microbiology, The University of Texas at Austin, Austin, Texas 78712, USA.
Palmer
Kelli L
KL
Whiteley
Marvin
M
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000188:drug therapy / Q000378:metabolism / Q000382:microbiology*; D050260:Carbohydrate Metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D008954:Models, Biological; D014774:Virulence
D000900:Anti-Bacterial Agents