Immune response in Wistar rats with high and low level of situational anxiety.
A large sample of Wistar rats was divided into 2 groups of high-anxiety and low-anxiety animals by the time spent in the open arms of the elevated plus-maze. This selection was based on the criterion of time (low-anxiety animals, not less than 10 sec; high-anxiety animals, not more than 2 sec). Immunization with T-dependent antigen was performed on the day of behavioral testing. The number of rosette-forming cells in high-anxiety rats significantly decreased on day 5 after immunization. A genetically determined relationship probably exists between low activity of the immune response and high level of reactive anxiety.
Loskutova
L V
LV
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. loskutova@iph.ma.nsc.ru
Idova
G V
GV
Gevorgyan
M M
MM
D000704:Analysis of Variance; D000818:Animals; D000955:Antigens, T-Independent / Q000276:immunology; D001007:Anxiety / Q000276:immunology* / Q000503:physiopathology* / Q000523:psychology; D005106:Exploratory Behavior / Q000502:physiology*; D007114:Immunization; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
D000955:Antigens, T-Independent