title: Stimulatory constituents of Eclipta prostrata on mouse osteoblast differentiation.
abstract: One flavonoid, diosmetin (1), and two isoflavonoids, 3'-hydroxybiochanin A (2) and 3'-O-methylorobol (3), were isolated from the methanol extract of Eclipta prostrata L. by a bioactivity-guided fractionation technique using primary cultures of mouse osteoblasts as an in vitro assay system. All three compounds significantly increased osteoblast differentiation as assessed by the alkaline phosphatase activity..
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Korea.
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
authors.forename: Na Ry
authors.initials: NR
authors.lastname: Ha
authors.forename: Hyekyung
authors.initials: H
authors.lastname: Yang
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Sung
authors.forename: Young Choong
authors.initials: YC
authors.lastname: Kim
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D036601:Eclipta / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D010006:Osteoblasts / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry
chemical_list: C534996:3'-O-methylorobol; C534995:3'-hydroxybiochanin A; D005419:Flavonoids; D007529:Isoflavones; D010936:Plant Extracts; C039602:diosmetin