title: Gated myocardial perfusion SPECT asynchrony measurements in patients with left bundle branch block.
abstract: OBJECTIVE
  This investigation sought to determine which newly available asynchrony parameter derived from gated myocardial perfusion SPECT (GMPS) systolic wall thickening data best distinguishes patients with left bundle branch block (LBBB) from normal subjects.
  
  
  METHODS
  Emory Cardiac Toolbox (ECTb) algorithms were used to compute left ventricular (LV) global and regional function and perfusion indices with regional contraction phases for 20 patients with LBBB, and in 9 control (CTL) subjects who had no function or perfusion abnormalities. Histogram plots of phase frequencies versus R-R interval times included phase standard deviation (SD), bandwidth (BW), skewness and kurtosis. Z-score asynchrony measures were derived for phases sampled using the conventional 17-segment model.
  
  
  RESULTS
  In CTLs contraction occurred nearly simultaneously in all segments, while LBBBs exhibited a wide variety of heterogeneous contraction patterns. Global parameters that differed between LBBBs versus CTLs included EF, end-systolic volume and end-diastolic volume, and asynchrony measures that were different included BW, phase SD and z-scores. Z-scores most strongly discriminated LBBBs from CTLs (93% of cases correctly predicted, logistic regression chi(2) = 29.7, P < 0.0001). Z-scores, phase SD and lateral-septal wall timing were highly reproducible (r = 0.99, 0.99 and r = 0.87, respectively), with no significant inter-observer differences.
  
  
  CONCLUSIONS
  While traditional global function parameters were different in LBBBs and CTLs, asynchrony parameters characterized LBBB most strongly.
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, North Shore-Long Island Jewish Health System, 270-05 76th Avenue, New Hyde Park, NY 11040, USA. knichols@lij.edu
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Nichols
authors.forename: Andrew
authors.initials: A
authors.lastname: Van Tosh
authors.forename: Saadi
authors.initials: S
authors.lastname: Siddiqi
authors.forename: Ji
authors.initials: J
authors.lastname: Chen
authors.forename: Ernest V
authors.initials: EV
authors.lastname: Garcia
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Palestro
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Reichek
mesh_terms: D000368:Aged; D000465:Algorithms; D002037:Bundle-Branch Block / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi