Toxicokinetics of fumonisin B1 in turkey poults and tissue persistence after exposure to a diet containing the maximum European tolerance for fumonisins in avian feeds.
The kinetic of fumonisin B1 (FB1) after a single IV and oral dose, and FB1 persistence in tissue were investigated in turkey poults by HPLC after purification of samples on columns. After IV administration (single-dose: 10mg FB1/kg bw), serum concentration-time curves were best described by a three-compartment open model. Elimination half-life and mean residence time of FB1 were 85 and 52min, respectively. After oral administration (single-dose: 100mg FB1/kg bw) bioavailability was 3.2%; elimination half-life and mean residence time were 214 and 408min, respectively. Clearance of FB1 was 7.6 and 7.5ml/min/kg for IV and oral administration, respectively. Twenty-four hours after the administration of FB1 by the intravenous route, liver and kidney contained the highest levels of FB1 in tissues, level in muscle was low or below the limit of detection (LD, 13microg/kg). The persistence of FB1 in tissue was also studied after administration for 9 weeks of a feed that contained 5, 10 and 20mg FB1+FB2/kg diet. Eight hours after the last intake of 20mg FB1+FB2/kg feed (maximum recommended concentration of fumonisins established by the EU for avian feed), hepatic and renal FB1 concentrations were 119 and 22microg/kg, level in muscles was below the LD.
Tardieu
Didier
D
ENVT, Mycotoxicology Unit, 31076 Toulouse Cedex 3, France.
Bailly
Jean-Denis
JD
Skiba
Fabien
F
Grosjean
François
F
Guerre
Philippe
P
D000821:Animal Feed / Q000032:analysis* / Q000592:standards; D000818:Animals; D019540:Area Under Curve; D002274:Carcinogens, Environmental / Q000493:pharmacokinetics* / Q000633:toxicity*; D002851:Chromatography, High Pressure Liquid; D003627:Data Interpretation, Statistical; D004032:Diet; D005062:European Union; D037341:Fumonisins / Q000493:pharmacokinetics* / Q000633:toxicity*; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D014018:Tissue Distribution; D014422:Turkeys / Q000502:physiology*
D002274:Carcinogens, Environmental; D037341:Fumonisins; C056933:fumonisin B1