title: Dioxins in adipose tissue of women in Southern Spain.
abstract: Seventeen polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) were quantified in adipose tissue samples of non-occupationally exposed women living in Southern Spain. Geometric mean levels of sum of congeners and WHO(PCDD/F)-TEQ(2005) were 410 and 17.9pgg(-1) fat, respectively. Among PCDDs, octachlorodibenzo-p-dioxin (OCDD) showed the highest concentration with a mean value of 265pgg(-1) fat, followed by 1,2,3,6,7,8-HxCDD (49.3pgg(-1) fat) and 1,2,3,4,6,7,8-HpCDD (45.2pgg(-1) fat). These three congeners were responsible for around 90% of the sum of all PCDD/F congeners in adipose tissue. The geometric mean 2,3,7,8-TCDD value was 1.87pgg(-1) fat. 2,3,4,7,8-PeCDF (8.43pgg(-1) fat) showed the highest concentration among the PCDFs, followed by 1,2,3,4,7,8-HxCDF (4.17pgg(-1) fat) and 1,2,3,6,7,8-HxCDF (3.28pgg(-1) fat), and these three congeners were responsible for 4% of the sum of all studied PCDD/F congeners in adipose tissue and 76% of the sum of ten PCDFs. 1,2,3,7,8,9-HxCDF was the only congener not quantified in any sample, while 1,2,3,4,7,8,9-HpCDF, 1,2,3,7,8-PeCDF, OCDF and 2,3,7,8-TCDF were found in 5, 16, 16 and 19 samples, respectively. All other congeners were quantifiable in all 20 samples. Congeners contributing most to the WHO(PCDD/F)-TEQ(2005) were 1,2,3,7,8-PeCDD (31.6%), 1,2,3,6,7,8-HxCDD (28.3%) and 2,3,4,7,8-PeCDF (14.6%). The body burden of log-transformed WHO(PCDD/F)-TEQ(2005) levels increased with age (B=0.02; 95% CI=0.01, 0.03; p=0.02). Although these adipose tissue PCDD/F levels are similar to previously published findings in Spain and other European countries, further research is needed to determine trends in the exposure of women to these chemical residues.
authors.affiliation: Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, 18071 Granada, CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Lopez-Espinosa
authors.forename: H
authors.initials: H
authors.lastname: Kiviranta
authors.forename: P
authors.initials: P
authors.lastname: Araque
authors.forename: P
authors.initials: P
authors.lastname: Ruokojärvi
authors.forename: J M
authors.initials: JM
authors.lastname: Molina-Molina
authors.forename: M F
authors.initials: MF
authors.lastname: Fernandez
authors.forename: T
authors.initials: T
authors.lastname: Vartiainen
authors.forename: N
authors.initials: N
authors.lastname: Olea
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D000328:Adult; D000368:Aged; D004147:Dioxins / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013030:Spain
chemical_list: D004147:Dioxins