Moving toward individualized cancer therapies.
In vivo analysis of the gene expression profiles of cancer cells before and after treatment in patients may define mechanisms of sensitivity and resistance to specific drugs and ultimately allow for the selection of optimal individualized therapy to improve outcome in cancer.
Tonon
Giovanni
G
Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Anderson
Kenneth C
KC
D017209:Apoptosis; D019008:Drug Resistance, Neoplasm; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007700:Kinetics; D008495:Medical Oncology / Q000379:methods; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy*; D010597:Pharmacogenetics / Q000379:methods*; D012680:Sensitivity and Specificity; D016896:Treatment Outcome