Diet and aging.
Interventions that extend life span by moderately reduced nutrient intake are often referred to as dietary or calorie restriction. Its efficacy in many species has led to the conclusion that a single, evolutionarily conserved, molecular mechanism operates in all cases to extend life. Here we discuss examples of diet/genotype interactions that show a more complex mechanistic view is required and that mild dietary modifications can dramatically change the interpretation of model organism aging studies.
Piper
Matthew D W
MD
UCL Institute of Healthy Ageing, University College London, London, WC1E 6BT, UK. m.piper@ucl.ac.uk
Bartke
Andrzej
A
D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism; D031204:Caloric Restriction / Q000379:methods*; D004330:Drosophila / Q000378:metabolism; D002149:Energy Intake / Q000502:physiology*; D005508:Food Deprivation / Q000502:physiology*; D005526:Food, Formulated / Q000592:standards; D006801:Humans; D008136:Longevity / Q000235:genetics*; D023421:Models, Animal; D009154:Mutation / Q000235:genetics