title: An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy.
abstract: The renin-angiotensin system in the brain acts to regulate a number of physiological processes. Evidence suggests that angiotensin peptides may act as neurotransmitters, although their biosynthetic pathways are poorly understood. We review evidence for neuronal production of angiotensin peptides and hypothesize that angiotensin may be synthesized intracellularly in neurons.
authors.affiliation: Department of Internal Medicine, Center on Functional Genomics of Hypertension, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
authors.forename: Justin L
authors.initials: JL
authors.lastname: Grobe
authors.forename: Di
authors.initials: D
authors.lastname: Xu
authors.forename: Curt D
authors.initials: CD
authors.lastname: Sigmund
mesh_terms: D000809:Angiotensins / Q000378:metabolism*; D000818:Animals; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D009490:Neurosecretory Systems / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D012084:Renin-Angiotensin System / Q000502:physiology*
chemical_list: D000809:Angiotensins; D018377:Neurotransmitter Agents