A practical and efficient route for the highly enantioselective synthesis of mexiletine analogues and novel beta-thiophenoxy and pyridyl ethers.
A practical and efficient procedure for the enantioselective synthesis of mexiletine analogues with use of 10% of spiroborate ester 6 as chirality transfer agent is presented. A variety of mexiletine analogues were prepared in good yield with excellent enantioselectivities (91-97% ee) from readily available starting materials. The developed methodology was also successfully applied for the synthesis of novel beta-amino ethers containing thiophenyl and pyridyl fragments.
Huang
Kun
K
Department of Chemistry, University of Puerto Rico-Humacao, CUH Station, Humacao, Puerto Rico.
Ortiz-Marciales
Margarita
M
Stepanenko
Viatcheslav
V
De Jesús
Melvin
M
Correa
Wildeliz
W
D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D001880:Boranes / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D004987:Ethers / Q000138:chemical synthesis*; D008801:Mexiletine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D008956:Models, Chemical; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism; D013876:Thiophenes / Q000737:chemistry*
D000889:Anti-Arrhythmia Agents; D001880:Boranes; D004952:Esters; D004987:Ethers; D011725:Pyridines; D013876:Thiophenes; D008801:Mexiletine