title: Atypical adenomatous hyperplasia (adenosis) of the prostate: a case report with review of the literature.
abstract: A 62-year-old male presented with symptoms of urinary obstruction and elevated serum prostate-specific antigen level of 3.61 ng/mL. Prostate needle biopsies showed benign prostatic tissue with a focus of crowded glands with minimal cytological atypia, fairly well-circumscribed with infiltrative appearance of glands at the edges. This focus had both small and larger glands with similar histological features. This focus was strongly positive for alpha-methylacyl-coenzyme A-racemase (AMACR), but showed scattered patchy staining with basal cell markers (p63 and CK903/34betaE12). Hence, the final histologic diagnosis was benign prostatic tissue with a focus of florid adenosis. Two subsequent follow-up prostate needle biopsies performed six and 12 months later both showed benign prostatic tissue with atrophic changes. This case highlights the utility of these three immunostains (AMACR, p63 and CK903/34betaE12) in the accurate diagnosis of adenosis of the prostate on needle biopsy, and avoiding its misinterpretation as prostate adenocarcinoma.
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA. armahh2@upmc.edu
authors.forename: Henry B
authors.initials: HB
authors.lastname: Armah
authors.forename: Anil V
authors.initials: AV
authors.lastname: Parwani