Neurodegeneration: RNA turns number one suspect in polyglutamine diseases.
Polyglutamine expansion diseases are triggered by the accumulation of toxic proteins. A new study reports that RNA molecules containing long CAG repeats can also be toxic to neurons and may play a significant role in pathogenesis.
Birman
Serge
S
Developmental Biology Institute of Marseille, CNRS UMR 6216, Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 9, France. birman@ibdml.univ-mrs.fr
D000818:Animals; D001483:Base Sequence; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D005973:Glutamine / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D010455:Peptides / Q000235:genetics / Q000378:metabolism*; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D019680:Trinucleotide Repeat Expansion
D029721:Drosophila Proteins; D009687:Nuclear Proteins; D010455:Peptides; C109271:mbl protein, Drosophila; D005973:Glutamine; C097188:polyglutamine; D012313:RNA