[Primary natural killer/T cell lymphoma of the lung: two cases report and clinical analysis].
OBJECTIVE
To describe the clinical and pathological features of primary NK/T cell lymphoma of the lung.


METHODS
Two cases of primary NK/T cell lymphoma of the lung were reported, and the clinical, radiological and pathological characteristics of the disease were discussed with literature review of 3 cases.


RESULTS
Most patients presented with fever, cough and dyspnea, and antibiotics were ineffective. Radiographic findings included solitary or multiple nodules and consolidation, unilateral orbilateral pleural effusions (4/5), without hilar or mediastinal adenopathy. Ebstein-Barr virus was positive in cases patients (3/5). Histopathology revealed a great deal of abnormal lymphocyte infiltration, which were angio-centric with marked tissue putrescence and angio-destruction. Immunophenotyping showed CD56(+), CD3(+), perform (+), T-cell intracytoplasmic antigen-1(+) and/or GranB(+), but CD20(-). Most patients died of respiratory failure in half a year (4/5).


CONCLUSIONS
Primary NK/T cell lymphoma of the lung is rare, but should be considered when patients present with lung shadows and fever non-responsive to antibiotics, decreased WBC and increased LDH.
Cao
Meng-Shu
MS
Department of Respiratory Medicine, The Affiliated Drum Tower Hospital, Nanjing University Medical College, Nanjing 210008, China.
Cai
Hou-Rong
HR
Yin
Hong-Lin
HL
Zhang
De-Ping
DP
Xiao
Yong-Long
YL
Cao
Min
M
Dai
Ling-Juan
LJ
Hou
Jie
J
D000328:Adult; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology; D054391:Lymphoma, Extranodal NK-T-Cell / Q000276:immunology / Q000473:pathology; D055815:Young Adult