Clarithromycin inhibits fibroblast migration.
The aim of the current study was to investigate the effect of 14-membered ring macrolide clarithromycin (CAM) on migration induced by human plasma fibronectin (HFn) or on contraction of human fetal lung fibroblasts (HFL-1).


RESULTS
Using the blindwell chamber technique, CAM (10(-5) M) inhibited the migration of HFL-1 60.2+/-4.0% (p<0.05). Other antibiotics, such as ampicillin, minocycline or azithromycin had no effects on HFL-1 migration. The effect of CAM was concentration dependent. HFL-1 migration, stimulated by TXA(2) analog was also inhibited by CAM. Clarithromycin had no effect on HFL-1 mediated gel contraction that was another function of fibroblast at the wound area.


CONCLUSIONS
Clarithromycin may contribute to the regulation of the wound healing response following injury by inhibiting fibroblast migration. These results could represent the therapeutic benefits of CAM.
Kohyama
Tadashi
T
Department of Respiratory Medicine, The University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8655, Japan. koyama-tky@umin.ac.jp
Yamauchi
Yasuhiro
Y
Takizawa
Hajime
H
Itakura
Susumu
S
Kamitani
Sumiko
S
Kato
Jun
J
Nagase
Takahide
T
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects*; D017291:Clarithromycin / Q000494:pharmacology*; D003094:Collagen / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects* / Q000502:physiology; D005353:Fibronectins / Q000494:pharmacology; D005782:Gels; D006801:Humans; D008168:Lung / Q000166:cytology
D000900:Anti-Bacterial Agents; D005353:Fibronectins; D005782:Gels; D003094:Collagen; D017291:Clarithromycin