title: Predicting coronary artery disease using different artificial neural network models.
abstract: OBJECTIVE
  Eight different learning algorithms used for creating artificial neural network (ANN) models and the different ANN models in the prediction of coronary artery disease (CAD) are introduced.
  
  
  METHODS
  This work was carried out as a retrospective case-control study. Overall, 124 consecutive patients who had been diagnosed with CAD by coronary angiography (at least 1 coronary stenosis > 50% in major epicardial arteries) were enrolled in the work. Angiographically, the 113 people (group 2) with normal coronary arteries were taken as control subjects. Multi-layered perceptrons ANN architecture were applied. The ANN models trained with different learning algorithms were performed in 237 records, divided into training (n=171) and testing (n=66) data sets. The performance of prediction was evaluated by sensitivity, specificity and accuracy values based on standard definitions.
  
  
  RESULTS
  The results have demonstrated that ANN models trained with eight different learning algorithms are promising because of high (greater than 71%) sensitivity, specificity and accuracy values in the prediction of CAD. Accuracy, sensitivity and specificity values varied between 83.63%-100%, 86.46%-100% and 74.67%-100% for training, respectively. For testing, the values were more than 71% for sensitivity, 76% for specificity and 81% for accuracy.
  
  
  CONCLUSIONS
  It may be proposed that the use of different learning algorithms other than backpropagation and larger sample sizes can improve the performance of prediction. The proposed ANN models trained with these learning algorithms could be used a promising approach for predicting CAD without the need for invasive diagnostic methods and could help in the prognostic clinical decision.
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine University of Firat, Elaziğ, Turkey. cemilcolak@yahoo.com
authors.forename: M Cengiz
authors.initials: MC
authors.lastname: Colak
authors.forename: Cemil
authors.initials: C
authors.lastname: Colak
authors.forename: Hasan
authors.initials: H
authors.lastname: Kocatürk
authors.forename: Seref
authors.initials: S
authors.lastname: Sağiroğlu
authors.forename: Irfan
authors.initials: I
authors.lastname: Barutçu
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016571:Neural Networks, Computer; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity