Factor VIIa binding to endothelial cell protein C receptor.
Recent studies have shown that factor VIIa (FVIIa) binds specifically to endothelial protein C receptor (EPCR), a known cellular receptor for protein C and activated protein C, on the endothelium. The formation of FVIIa:EPCR complexes neither supports the activation of coagulation nor modulates tissue factor-initiated coagulation. However, FVIIa interaction with EPCR, particularly at pharmacological concentrations of FVIIa, may impair EPCR-dependent protein C activation and activated protein C-mediated cell signaling by competing directly with them for binding to EPCR. FVIIa binding to EPCR may also contribute to FVIIa clearance. This review summarizes recent data on FVIIa interaction with EPCR and discusses potential physiological significance and consequences of the interaction.
Rao
L Vijaya Mohan
LV
Center for Biomedical Research, The University of Texas Health Science Center, Tyler, TX, USA. vijay.rao@uthct.edu
Pendurthi
Usha R
UR
D000925:Anticoagulants / Q000378:metabolism; D001779:Blood Coagulation Factors / Q000502:physiology*; D002478:Cells, Cultured; D003029:Coagulants / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D015942:Factor VIIa / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D011486:Protein C / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology*; D014471:Umbilical Veins / Q000166:cytology
D000925:Anticoagulants; D001779:Blood Coagulation Factors; D003029:Coagulants; D011486:Protein C; D011956:Receptors, Cell Surface; C091963:activated protein C receptor; D015942:Factor VIIa