Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety.
Crocus sativus L. is a plant cultivated in various parts of the world. Crocins are among the active components of Crocus sativus L. The present study was designed to investigate in the rat whether or not crocins possess anxiolytic properties. For this aim, the light/dark test was selected. Either crocins, at a dose which did not influence animals' motor activity (50mg/kg), or diazepam (1.5 mg/kg), significantly increased the latency to enter the dark compartment and prolonged the time spent in the lit chamber in the rats. Conversely, lower doses of crocins (15-30 mg/kg) did not substantially modify animals' behaviour. The present results indicate that treatment with these active constituents of Crocus sativus L. induce anxiolytic-like effects in the rat.
Pitsikas
N
N
Department of Pharmacology, School of Medicine, University of Thessaly, Larissa, Greece. npitsikas@med.uth.gr
Boultadakis
A
A
Georgiadou
G
G
Tarantilis
P A
PA
Sakellaridis
N
N
D000818:Animals; D014151:Anti-Anxiety Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy*; D002338:Carotenoids / Q000302:isolation & purification / Q000494:pharmacology*; D027622:Crocus / Q000737:chemistry*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D014151:Anti-Anxiety Agents; D010936:Plant Extracts; D002338:Carotenoids; C029036:crocin