title: Survivin and epidermal growth factor receptor expression in surgically treated oropharyngeal squamous cell carcinoma.
abstract: BACKGROUND
  The epidermal growth factor receptor (EGFR) and the inhibitor of apoptosis protein survivin play important roles in the regulation of cellular proliferation and survival in squamous cell carcinomas. Their correlation in oropharyngeal squamous cell carcinoma (OSCC) has not been evaluated yet.
  
  
  METHODS
  In this multicenter study, we analyzed the expression of survivin and EGFR in tissue specimens from 73 selected patients with OSCC using immunohistochemistry.
  
  
  RESULTS
  Higher cytoplasmic survivin scores were significantly correlated with high scores of EGFR expression (p=.013). Nuclear survivin expression was associated with a poor overall survival rate with an estimated 3-year overall survival probability of 17.3% versus 87.4% for non-nuclear expression of survivin (p<.001). Multivariate analysis revealed that nuclear survivin expression was an independent negative prognostic factor (p=.008).
  
  
  CONCLUSIONS
  Considering the strong impact of nuclear survivin expression on survival, the survivin expression should be prospectively evaluated to select patients with an increased risk for disease recurrence.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Cologne, Cologne, Germany. simon.preuss@uni-kohln.de
authors.forename: Simon Florian
authors.initials: SF
authors.lastname: Preuss
authors.forename: Antje
authors.initials: A
authors.lastname: Weinell
authors.forename: Markus
authors.initials: M
authors.lastname: Molitor
authors.forename: Robert
authors.initials: R
authors.lastname: Semrau
authors.forename: Markus
authors.initials: M
authors.lastname: Stenner
authors.forename: Uta
authors.initials: U
authors.lastname: Drebber
authors.forename: Inga
authors.initials: I
authors.lastname: Wedemeyer
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Hoffmann
authors.forename: Orlando
authors.initials: O
authors.lastname: Guntinas-Lichius
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Klussmann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000601:surgery; D015853:Cysteine Proteinase Inhibitors / Q000032:analysis*; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins; D008297:Male; D008869:Microtubule-Associated Proteins / Q000032:analysis*; D008875:Middle Aged; D015999:Multivariate Analysis; D009363:Neoplasm Proteins / Q000032:analysis*; D009959:Oropharyngeal Neoplasms / Q000737:chemistry* / Q000601:surgery; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D015853:Cysteine Proteinase Inhibitors; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin; D066246:ErbB Receptors