title: Enhanced dissolution of ibuprofen using solid dispersion with polyethylene glycol 20000.
abstract: To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared in a relatively easy and simple manner, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR), and evaluated for solubility and in vitro drug release. Loss of individual surface properties during melting and re-solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting toward the lower melting temperature of the drug peak in SDs in DSC study indicated the possibilities of drug-polymer interactions. FTIR spectra showed the presence of drug crystalline in SDs. The effect of improved dissolution on the oral absorption of ibuprofen in rats was also studied. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C(max), and a significant decrease in T(max) over pure ibuprofen. Preliminary results from this study suggested that the preparation of fast dissolving ibuprofen SDs by low-temperature melting method using polyethylene glycol 20000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution, and absorption rate of ibuprofen.
authors.affiliation: College of Pharmacy, Yeungnam University, Kyungsan, Kyungbuk, South Korea.
authors.forename: Madhuri
authors.initials: M
authors.lastname: Newa
authors.forename: Krishna Hari
authors.initials: KH
authors.lastname: Bhandari
authors.forename: Dong Xun
authors.initials: DX
authors.lastname: Lee
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Sung
authors.forename: Jung Ae
authors.initials: JA
authors.lastname: Kim
authors.forename: Bong Kyu
authors.initials: BK
authors.lastname: Yoo
authors.forename: Jong Soo
authors.initials: JS
authors.lastname: Woo
authors.forename: Han Gon
authors.initials: HG
authors.lastname: Choi
authors.forename: Chul Soon
authors.initials: CS
authors.lastname: Yong
mesh_terms: D000818:Animals; D002152:Calorimetry, Differential Scanning; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D008297:Male; D008855:Microscopy, Electron, Scanning; D011092:Polyethylene Glycols / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D011092:Polyethylene Glycols; D007052:Ibuprofen