The effect of insulin-like growth factor-I, relaxin and luteinizing hormone on vascular endothelial growth factor secretion by cultured endometrial stromal cells on different days of early pregnancy in pigs.
The effect of insulin-like growth factor-I (IGF-I), relaxin (RLX) and luteinizing hormone (LH) on vascular endothelial growth factor (VEGF) in vitro secretion by endometrial stromal cells in pigs was investigated on days 10-12 and 20-22 of gestation. LH-stimulated stromal cell secretion of VEGF did not differ among tested days of early pregnancy. However, IGF-I- and RLX-mediated release of VEGF depended on the day of pregnancy. It seems that IGF-I and RLX may be considered as potent activators of VEGF-mediated angiogenesis in porcine endometrium, and their action may be more pronounced during maternal recognition of pregnancy.
Kaczmarek
Monika M
MM
Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, Poland. moka@pan.olsztyn.pl
Blitek
Agnieszka
A
Schams
Dieter
D
Ziecik
Adam J
AJ
D000818:Animals; D002478:Cells, Cultured; D004717:Endometrium / Q000166:cytology*; D005260:Female; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000494:pharmacology*; D018919:Neovascularization, Physiologic / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D012065:Relaxin / Q000494:pharmacology*; D017154:Stromal Cells / Q000378:metabolism; D013552:Swine; D013997:Time Factors; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D042461:Vascular Endothelial Growth Factor A; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone; D012065:Relaxin