title: Tetracycline gel as an adjunct to surgical root debridement.
abstract: OBJECTIVE
  To evaluate the influence of tetracycline gel, brushed on tooth surfaces, on periodontal clinical parameters following root debridement.
  
  
  METHODS
  20 subjects diagnosed with chronic periodontitis and presenting a minimum of two proximal sites on anterior teeth (maxillary or mandibular) with probing depth +/- 5 mm, were selected. Following oral hygiene instructions and ultrasonic supragingival instrumentation, subjects were assigned to one of the following groups: RDS--root debridement with Gracey curettes and root brushing with saline solution; and RDT--root debridement with Gracey curettes and root brushing with 40% tetracycline gel. Full-thickness flaps were reflected and instrumentation was performed using a clinical microscope to optimize calculus detection. Probing depth (PD), relative gingival margin level (RGML) and relative attachment level (RAL) measures were registered at five visits: baseline and days 30, 60, 90 and 120 postoperative.
  
  
  RESULTS
  Both approaches were able to markedly reduce the PD values from baseline in all periods (P < 0.0001). No differences were found for RAL values in any of the groups. No differences were found between groups. In conclusion, the application of tetracycline gel does not seem to provide any additional improvement on clinical periodontal parameters after root debridement.
authors.affiliation: Division of Prosthodontics and Periodontics, School of Dentistry at Piracicaba, São Paulo, Brazil. periodontia@fop.unicamp.br
authors.forename: Antonio Wilson
authors.initials: AW
authors.lastname: Sallum
authors.forename: Renato
authors.initials: R
authors.lastname: Vasconcelos Alves
authors.forename: Lúcio Flávio
authors.initials: LF
authors.lastname: Teixeira Damis
authors.forename: Patricia Fernanda
authors.initials: PF
authors.lastname: Roesler Bertolini
authors.forename: Francisco Humberto
authors.initials: FH
authors.lastname: Nociti Junior
authors.forename: Enilson Antonio
authors.initials: EA
authors.lastname: Sallum
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D012534:Dental Scaling; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D005889:Gingival Recession / Q000188:drug therapy / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009910:Oral Hygiene; D017622:Periodontal Attachment Loss / Q000188:drug therapy / Q000628:therapy; D010514:Periodontal Pocket / Q000188:drug therapy / Q000628:therapy; D010518:Periodontitis / Q000188:drug therapy / Q000628:therapy*; D016745:Root Planing; D013357:Subgingival Curettage; D013524:Surgical Flaps; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D014092:Tooth Root / Q000187:drug effects / Q000473:pathology; D014464:Ultrasonic Therapy
chemical_list: D000900:Anti-Bacterial Agents; D005782:Gels; D013752:Tetracycline