title: Diverse contexts of zoonotic transmission of simian foamy viruses in Asia.
abstract: In Asia, contact between persons and nonhuman primates is widespread in multiple occupational and nonoccupational contexts. Simian foamy viruses (SFVs) are retroviruses that are prevalent in all species of nonhuman primates. To determine SFV prevalence in humans, we tested 305 persons who lived or worked around nonhuman primates in several South and Southeast Asian countries; 8 (2.6%) were confirmed SFV positive by Western blot and, for some, by PCR. The interspecies interactions that likely resulted in virus transmission were diverse; 5 macaque taxa were implicated as a potential source of infection. Phylogenetic analysis showed that SFV from 3 infected persons was similar to that from the nonhuman primate populations with which the infected persons reported contact. Thus, SFV infections are likely to be prevalent among persons who live or work near nonhuman primates in Asia.
authors.affiliation: Division of International Programs, National Primate Research Center, University of Washington, Seattle, Washington 98195, USA. jonesengel@bart.rprc.washington.edu
authors.forename: Lisa
authors.initials: L
authors.lastname: Jones-Engel
authors.forename: Cynthia C
authors.initials: CC
authors.lastname: May
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Engel
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Steinkraus
authors.forename: Michael A
authors.initials: MA
authors.lastname: Schillaci
authors.forename: Agustin
authors.initials: A
authors.lastname: Fuentes
authors.forename: Aida
authors.initials: A
authors.lastname: Rompis
authors.forename: Mukesh K
authors.initials: MK
authors.lastname: Chalise
authors.forename: Nantiya
authors.initials: N
authors.lastname: Aggimarangsee
authors.forename: Mohammed M
authors.initials: MM
authors.lastname: Feeroz
authors.forename: Richard
authors.initials: R
authors.lastname: Grant
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Allan
authors.forename: Arta
authors.initials: A
authors.lastname: Putra
authors.forename: I Nengah
authors.initials: IN
authors.lastname: Wandia
authors.forename: Robin
authors.initials: R
authors.lastname: Watanabe
authors.forename: LaRene
authors.initials: L
authors.lastname: Kuller
authors.forename: Satawat
authors.initials: S
authors.lastname: Thongsawat
authors.forename: Romanee
authors.initials: R
authors.lastname: Chaiwarith
authors.forename: Randall C
authors.initials: RC
authors.lastname: Kyes
authors.forename: Maxine L
authors.initials: ML
authors.lastname: Linial
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D018420:Ape Diseases / Q000635:transmission / Q000821:virology; D001208:Asia / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D010802:Phylogeny; D012192:Retroviridae Infections / Q000453:epidemiology / Q000635:transmission*; D053150:Simian foamy virus; D015047:Zoonoses / Q000635:transmission*
chemical_list: D004279:DNA, Viral