Expedient total syntheses of WIN 64745 and WIN 64821.
Bispyrrolidinoindoline diketopiperazine alkaloids were synthesized from a common intermediate in seven steps from commercially available amino acids. This versatile synthetic strategy has led to the accomplishment of the first total synthesis of heterodimeric WIN 64745 and a novel approach to homodimeric WIN 64821.
Pérez-Balado
Carlos
C
Departamento de Química Orgánica, Facultade de Química, Universidade de Vigo, As Lagoas-Marcosende, 36310 Vigo, Spain.
de Lera
Angel R
AR
D026121:Indole Alkaloids / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis; D010649:Phenylalanine / Q000737:chemistry; D010879:Piperazines / Q000138:chemical synthesis; D011759:Pyrrolidines / Q000138:chemical synthesis; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014364:Tryptophan / Q000737:chemistry
D026121:Indole Alkaloids; D007211:Indoles; D010879:Piperazines; D011759:Pyrrolidines; D011763:Pyrrolizidine Alkaloids; D010649:Phenylalanine; D014364:Tryptophan