[Premature ovarian failure: which protocols?].
This review shows the results of the various studies concerning the protocols applied to the women presenting a premature ovarian failure. Will be thus analyzed the natural cycles (or semi-natural), the increase in the dose of gonadotrophins, the clomiphene citrate and the anti-aromatases, the protocols with GnRH agonists long, short, stop or microdoses, the protocols with GnRH antagonists and the adjuvant treatments: aspirin, nitric oxyde, recombinant LH recombining, growth hormone and androgens. The interest of several protocols is to collect a sufficient number of oocytes (and thus of embryos to be transferred), making it possible to obtain reasonable rates of pregnancy. However, it arises that the rates of pregnancy observed among these women depend not only on their ovarian reserve and their age, but are also function of the type of infertility, of the cycle number and the uterus.
Merviel
P
P
Service de gynécologie obstétrique et médecine de la reproduction, centre d'Assistance médicale à la procréation (AMP), CHU d'Amiens, 124, rue Camille-Desmoulins, 80054 Amiens cedex 1, France. Merviel.Philippe@chu-amiens.fr
Lourdel
E
E
Boulard
V
V
Cabry
R
R
Claeys
C
C
Oliéric
M-F
MF
Sanguinet
P
P
Brasseur
F
F
Henri
I
I
Copin
H
H
D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D006062:Gonadotropins / Q000502:physiology* / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D016649:Primary Ovarian Insufficiency / Q000150:complications* / Q000628:therapy
D006062:Gonadotropins; D007987:Gonadotropin-Releasing Hormone