title: Accuracy of quantitative reconstructions in SPECT/CT imaging.
abstract: The goal of this study was to determine the quantitative accuracy of our OSEM-APDI reconstruction method based on SPECT/CT imaging for Tc-99m, In-111, I-123, and I-131 isotopes. Phantom studies were performed on a SPECT/low-dose multislice CT system (Infinia-Hawkeye-4 slice, GE Healthcare) using clinical acquisition protocols. Two radioactive sources were centrally and peripherally placed inside an anthropometric Thorax phantom filled with non-radioactive water. Corrections for attenuation, scatter, collimator blurring and collimator septal penetration were applied and their contribution to the overall accuracy of the reconstruction was evaluated. Reconstruction with the most comprehensive set of corrections resulted in activity estimation with error levels of 3-5% for all the isotopes.
authors.affiliation: Department of Radiology, University of British Columbia, 366-828 West 10th Avenue, Vancouver BC, V5Z 1L8, Canada. shcher2@interchange.ubc.ca
authors.forename: S
authors.initials: S
authors.lastname: Shcherbinin
authors.forename: A
authors.initials: A
authors.lastname: Celler
authors.forename: T
authors.initials: T
authors.lastname: Belhocine
authors.forename: R
authors.initials: R
authors.lastname: Vanderwerf
authors.forename: A
authors.initials: A
authors.lastname: Driedger
mesh_terms: D000465:Algorithms; D000886:Anthropometry; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007205:Indium Radioisotopes / Q000494:pharmacology; D007457:Iodine Radioisotopes / Q000494:pharmacology; D015233:Models, Statistical; D019047:Phantoms, Imaging; D017785:Photons; D049268:Positron-Emission Tomography / Q000379:methods; D015203:Reproducibility of Results; D013667:Technetium / Q000494:pharmacology; D013909:Thorax / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D013667:Technetium