[Sirenomelia as a part of VACTERL association: a study of three cases].
Sirenomelia, characterized by a fusion of lower limb buds, is rare. Moreover, the coexistence of this malformation with a VACTERL sequence is exceptional. We report, here, three new observations associating these two diseases on fetuses from 14 to 26 weeks gestation. With these three new cases associating sirenomelia and VACTERL, observed in our unit and examined in light of data from the medical literature, we discuss the embryologic origin of such malformations and the nosologic frontiers between these two diseases.
Charlier
Philippe
P
Service d'anatomie et de cytologie pathologiques, CHRU de Lille, avenue Oscar-Lambret, Lille cedex, France. ph.charlier@yahoo.fr
Valat
Anne-Sylvie
AS
Boute
Odile
O
Petit
Stéphanie
S
Chafiotte
Caroline
C
Huynh-Charlier
Isabelle
I
Gosselin
Bernard
B
Devisme
Louise
L
D000015:Abnormalities, Multiple / Q000196:embryology / Q000473:pathology; D004452:Echocardiography; D004480:Ectromelia / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005333:Fetus / Q000002:abnormalities* / Q000473:pathology*; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D016216:Ultrasonography, Prenatal