title: Continuous glucose monitoring time series and hypo/hyperglycemia prevention: requirements, methods, open problems.
abstract: A clinically important task in diabetes management is the prevention of hypo/hyperglycemic events. The availability of continuous glucose monitoring (CGM) devices allow to develop new strategies, but new problems have also emerged. In this contribution, we discuss three major challenges which, in practical real time CGM applications, should be dealt with: filtering to enhance the signal-to-noise ratio, ahead-of-time prediction of glucose concentration, and generation of hypo/hyper-alerts. For all these challenges, some techniques, with a different degree of sophistication, have been proposed recently in the literature, but several issues remain open.
authors.affiliation: Department of Information Engineering, University of Padova, Italy, Via G. Gradenigo 6/B 35131, Padova, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sparacino
authors.forename: Andrea
authors.initials: A
authors.lastname: Facchinetti
authors.forename: Alberto
authors.initials: A
authors.lastname: Maran
authors.forename: Claudio
authors.initials: C
authors.lastname: Cobelli
mesh_terms: D001331:Automation; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D004867:Equipment Design; D006801:Humans; D007700:Kinetics; D018670:Monitoring, Ambulatory / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D008991:Monitoring, Physiologic / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D001786:Blood Glucose