title: The treatment of fatigue.
abstract: Fatigue is a psychophysiological state that acts on the subject's motivation to engage in and/or to continue strenuous physical or cognitive activities. In various pathological conditions fatigue seems to lose this homeostatic function and presents itself as a symptom. The pathophysiology of fatigue is complex and includes neurological (central and peripheral) dysfunction, and altered neurotransmitter, cytokine, and hormonal settings. Treatment interventions are generally based on a sequential approach including treatment of comorbid factors, nonpharmacological treatments, and drugs.
authors.affiliation: Laboratorio Potenziali Evocati, Istituto Neurologico C. Mondino, Via Mondino 2, 27100, Pavia, Italy. alfredo.romani@mondino.it
authors.forename: Alfredo
authors.initials: A
authors.lastname: Romani
mesh_terms: D002490:Central Nervous System / Q000276:immunology / Q000503:physiopathology*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D015928:Cognitive Behavioral Therapy / Q000592:standards; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D003937:Diagnosis, Differential; D005081:Exercise Therapy / Q000592:standards; D015673:Fatigue Syndrome, Chronic / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy*; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D018377:Neurotransmitter Agents / Q000276:immunology / Q000378:metabolism
chemical_list: D000697:Central Nervous System Stimulants; D016207:Cytokines; D018377:Neurotransmitter Agents