Monodisperse hyaluronan polymers: synthesis and potential applications.
In many cases, the cellular response to hyaluronan (HA) depends on the molecular weight (MW) of the polymer chain. Most HA preparations from Nature or its derivatives possess wide size distributions called polydisperse. New chemoenzymatic synthesis technology allows the production of very narrow size distribution polymers called monodisperse. The use of stoichiometrically controlled and synchronized polymerization reactions allows an assortment of new HA reagents in the range of 10 kDa to 2,500 kDa for answering HA biology questions or potentially treating disease.
DeAngelis
Paul L
PL
Dept. of Biochemistry and Molecular Biology, Oklahoma Center for Medical Glycobiology, Univ. of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd, Oklahoma City, OK 73126, USA. paul-deangelis@ouhsc.edu
D001709:Biotechnology / Q000379:methods*; D002384:Catalysis; D014453:Glucuronosyltransferase / Q000737:chemistry; D000076002:Hyaluronan Synthases; D006820:Hyaluronic Acid / Q000138:chemical synthesis / Q000627:therapeutic use; D008970:Molecular Weight; D010316:Particle Size; D010325:Pasteurella / Q000201:enzymology; D011108:Polymers / Q000138:chemical synthesis / Q000627:therapeutic use
D011108:Polymers; D006820:Hyaluronic Acid; D014453:Glucuronosyltransferase; D000076002:Hyaluronan Synthases