Facile synthesis of structurally diverse 3,3'-disubstituted 1,1'-binaphthyl-2,2'-diamines in optically pure forms.
A new synthetic route to 3,3'-dihalo BINAMs based on the direct halogenation of H8-BINAM and subsequent rearomatization to the binaphthyl core has been developed. The combination of this new procedure and Pd-catalyzed coupling reactions enabled us to synthesize various 3,3'-disubstituted BINAMs in only three steps starting from H8-BINAM.
Kano
Taichi
T
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
Tanaka
Youhei
Y
Osawa
Kenta
K
Yurino
Taiga
T
Maruoka
Keiji
K
D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
C500338:1,1'-binaphthyl-2,2'-diamine; D003959:Diamines; D009281:Naphthalenes