[A multi-centers clinical study of different treatment outcomes of 332 patients with multiple myeloma].
OBJECTIVE
To describe the demographic and clinical characteristics of patients with the diagnosis of multiple myeloma (MM) and to analyse the outcome of different regimens for the treatment of MM.


METHODS
The study reviewed 332 MM cases diagnosed within the period from January 1, 2002 to December 31, 2002. These patients were tracked via their records to a total period of three years.


RESULTS
First-line treatment: Totally 332 patients were included, among them 325 (97.9%) patients received chemotherapy and 7 (2.1%) patients received stem cell transplantation (SCT); Second-line treatment: 197 patients were included, among them 190 (96.5%) patients received chemotherapy and 7 (3.6%) patients received SCT; Third-line treatment: 92 patients were included,among them 88 (95.7%) patients received chemotherapy and 4 (4.4%) patients received SCT. Major adverse effects were follows: severe infection 19.3%, severe anaemia 19.3%, phlebothrombosis 1.2% , thrombocytopenia 16.9%, fever associated with neutropenia 18.1%.


CONCLUSIONS
Some curative effects can be achieved by using traditional treatment plans to treat patients suffering from MM, but new methods are expected to improve the prognosis.
Xue
Kai
K
Department of Hematology, Ruijin Hospital, being Affiliated to Shanghai Jiaotong University, Shanghai 200025, China. xuekaishanghai@126.com
Qiu
Lu-gui
LG
Liu
Ting
T
Hou
Jian
J
Huang
Xiao-jun
XJ
Ma
Jun
J
Chen
Xie-qun
XQ
Yu
Li
L
Jin
Jie
J
Wu
De-pei
DP
Wu
Yong-ji
YJ
Meng
Fan-yi
FY
Li
Jian-yong
JY
Chen
Wen-ming
WM
Wang
Chun
C
Wang
Jian-min
JM
Huang
Zi-lun
ZL
Zou
Ping
P
Lou
Shi-feng
SF
Ouyang
Jian
J
Zhou
Fan
F
Du
Xin
X
Shen
Zhi-xiang
ZX
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000209:etiology; D004358:Drug Therapy / Q000706:statistics & numerical data; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007239:Infections / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000706:statistics & numerical data; D016019:Survival Analysis; D013921:Thrombocytopenia / Q000209:etiology; D016896:Treatment Outcome