title: Determinants of kidney function in Swedish families: role of heritable factors.
abstract: The aim of this study was to evaluate the determinants of kidney function and the role of heritable factors in a sample of 249 siblings free from known cardiovascular disease and without antihypertensive drugs belonging to 110 families. Four different measures and estimates of kidney function were considered. Blood pressure was recorded during 24 h by ambulatory blood pressure monitoring. Heritability was estimated with and without adjustment for significant covariates.In multivariate analysis, in addition to age, sex, BMI, HDL-cholesterol, 24-h systolic and mean blood pressure, systolic nocturnal blood pressure dipping resulted independently related to serum creatinine, estimated Cockcroft-Gault-creatinine clearance and estimated by the modification of diet in renal disease-glomerular filtration rate. After full adjustment, the heritability values were 51% for the measured creatinine clearance (P < 0.01), 58% for the estimated Cockcroft-Gault-creatinine clearance (P < 0.001), 40% for the estimated by the modification of diet in renal disease-glomerular filtration rate (P < 0.001), but 8% (P = 0.34) for serum creatinine.Our data confirm that kidney function is partially under genetic control and that genetic variants of importance for this trait could be mapped. The association of the circadian rhythm of blood pressure with kidney function in this sample deserves further investigation.
authors.affiliation: Department of Clinical Sciences, Lund University, University Hospital of Malmö, Malmö, Sweden. cristiano.fava@med.lu.se
authors.forename: Cristiano
authors.initials: C
authors.lastname: Fava
authors.forename: Martina
authors.initials: M
authors.lastname: Montagnana
authors.forename: Philippe
authors.initials: P
authors.lastname: Burri
authors.forename: Peter
authors.initials: P
authors.lastname: Almgren
authors.forename: Pietro
authors.initials: P
authors.lastname: Minuz
authors.forename: U Lennart
authors.initials: UL
authors.lastname: Hulthén
authors.forename: Olle
authors.initials: O
authors.lastname: Melander
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002940:Circadian Rhythm; D003404:Creatinine / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005919:Glomerular Filtration Rate; D006801:Humans; D006977:Hypertension, Renal / Q000453:epidemiology* / Q000235:genetics* / Q000503:physiopathology; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010641:Phenotype; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology
chemical_list: D003404:Creatinine