Selective chemical rescue of a thyroid-hormone-receptor mutant, TRbeta(H435Y), identified in pituitary carcinoma and resistance to thyroid hormone.
Hassan
A Quamrul
AQ
Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
Koh
John T
JT
D020816:Amino Acid Motifs; D019943:Amino Acid Substitution; D002277:Carcinoma / Q000235:genetics* / Q000378:metabolism; D006639:Histidine / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008024:Ligands; D008956:Models, Chemical; D009154:Mutation; D010911:Pituitary Neoplasms / Q000235:genetics* / Q000378:metabolism; D011487:Protein Conformation; D037042:Thyroid Hormone Receptors beta / Q000819:agonists / Q000737:chemistry* / Q000235:genetics*; D014284:Triiodothyronine / Q000378:metabolism* / Q000494:pharmacology; D014443:Tyrosine / Q000737:chemistry / Q000235:genetics
D008024:Ligands; D037042:Thyroid Hormone Receptors beta; D014284:Triiodothyronine; D014443:Tyrosine; D006639:Histidine