title: The effect of sterilization processes on the bioadhesive properties and surface chemistry of a plasma-polymerized polyethylene glycol film: XPS characterization and L929 cell proliferation tests.
abstract: The influence of several sterilization processes (autoclaving, gamma-ray irradiation, ethylene oxide exposure and Ar/H(2) low pressure plasma treatment) on the surface chemistry and the bioadhesive properties of thin films (thickness approximately 20 nm) of plasma-polymerized diethylene glycol dimethyl ether has been studied. X-ray photoelectron spectroscopy (XPS) analysis and cell proliferation tests were used to characterize the surfaces. The XPS results revealed in all cases a change in the surface chemistry of the layer after sterilization, whereas the conservation of non-bioadhesive properties of the coating depends on the type of sterilization process. In particular, the low pressure plasma-based sterilization technique leads to a loss of the non-bioadhesive properties of the plasma coating, whereas the coatings are resistant to the other standard decontamination techniques. This property makes them suitable for biomedical applications, provided that an appropriate sterilization process is selected.
authors.affiliation: European Commission Joint Research Centre, Institute for Health and Consumer Protection, Via Fermi 1, 21027 Ispra (VA), Italy.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Brétagnol
authors.forename: Hubert
authors.initials: H
authors.lastname: Rauscher
authors.forename: Marina
authors.initials: M
authors.lastname: Hasiwa
authors.forename: Ondrej
authors.initials: O
authors.lastname: Kylián
authors.forename: Giaccomo
authors.initials: G
authors.lastname: Ceccone
authors.forename: Len
authors.initials: L
authors.lastname: Hazell
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Paul
authors.forename: Olivier
authors.initials: O
authors.lastname: Lefranc
authors.forename: François
authors.initials: F
authors.lastname: Rossi
mesh_terms: D000268:Adhesiveness; D000269:Adhesives / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation; D005027:Ethylene Oxide / Q000737:chemistry; D005347:Fibroblasts / Q000378:metabolism; D005720:Gamma Rays; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry*; D011312:Pressure; D013242:Sterilization / Q000379:methods*; D013499:Surface Properties; D014965:X-Rays
chemical_list: D000269:Adhesives; D001672:Biocompatible Materials; D011092:Polyethylene Glycols; D005027:Ethylene Oxide