title: [Characterization of immunity status in exposed residents of the Techa riverside villages 50 years after the onset of radiation exposure].
abstract: The goal of the study was to assess the state of immunity in exposed residents of the Techa riverside villages 50 years, or more, after the onset of radiation exposure. 127 chronically exposed persons and 55 unexposed persons were studied. The mean dose to red bone marrow (RBM) was 0.69 Sv in exposed subjects, the mean dose to soft tissue was 0.07 Sv, the mean dose rate amounted to 0.10 Sv/yr to RBM and 0.02 Sv/yr to soft tissues in 1950. The state of the basic links of the immunity system (cellular, humoral, mononuclear phagocyte system, cytokine spectrum, etc.) was assessed using conventional methods. Exposed persons manifested a significant reduction in the absolute counts of CD3+, CD4+, CD 11b+, CD16+ lymphocytes in the peripheral blood, as well as an increase in the relative counts of CD8+. The group comprised of the Techa riverside residents demonstrated an increased immunoregulatory index (exposed individuals: 1.47; controls: 1.71, p = 0.001). An increased production of Immunoglobulin A and increased proportions of CD25+ lymphocytes were revealed in exposed individuals. Changes in the phagocytic activity of neutrophils and monocytes were insignificant, and were primarily associated with changes in the proportions of pagocytes in the peripheral blood stream. The state of the immunity in chronically exposed individuals at late time after the begin of exposure is characterized by a number of specific features reflected primarily on the cellular immunity. No relationship between immunity changes and accumulated exposure dose and dose rate were noted over the period of maximum radiation exposures (1950).
authors.forename: A V
authors.initials: AV
authors.lastname: Akleev
authors.forename: E A
authors.initials: EA
authors.lastname: Ovcharova
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007107:Immune System / Q000528:radiation effects*; D007070:Immunoglobulin A / Q000097:blood; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology / Q000528:radiation effects; D009504:Neutrophils / Q000276:immunology / Q000528:radiation effects; D010587:Phagocytosis / Q000528:radiation effects; D011832:Radiation Injuries / Q000097:blood / Q000276:immunology*; D045483:Rivers / Q000737:chemistry; D012424:Rural Population; D012800:Siberia; D013326:Strontium Radioisotopes / Q000633:toxicity*; D013997:Time Factors; D014875:Water Pollutants, Radioactive / Q000633:toxicity*
chemical_list: D015703:Antigens, CD; D007070:Immunoglobulin A; D013326:Strontium Radioisotopes; D014875:Water Pollutants, Radioactive