title: Gene therapy of arthritis and orthopaedic disorders: current experimental approaches in China and in Canada.
abstract: BACKGROUND
  Gene therapy offers new possibilities for the clinical management of orthopaedic conditions that are difficult to treat by traditional surgical or medical means.
  
  
  OBJECTIVE
  This review discusses the different gene therapy strategies available today, the safety issues with which they may be associated, and the potential for cooperation between China and Canada.
  
  
  CONCLUSIONS
  In the last decade, extensive improvements have been made to optimize gene therapy and have been tested on several orthopaedic conditions. China is a pioneer in some fields of gene therapy; the first anticancer gene therapy drug has been licensed in China. Canada has a very active research establishment and a populace that embraces new scientific developments, especially in medical sciences.
authors.affiliation: Shanghai Jiao Tong University, Insititue of Health Sciences, School of Medicine, Chinese Academy of Sciences, 225 South Chongqing Road, Shanghai 200025, China.
authors.forename: Ke-Rong
authors.initials: KR
authors.lastname: Dai
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Zhang
authors.forename: Qin
authors.initials: Q
authors.lastname: Shi
authors.forename: Julio C
authors.initials: JC
authors.lastname: Fernandes
mesh_terms: D001168:Arthritis / Q000628:therapy*; D002170:Canada; D002681:China; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D007592:Joint Diseases / Q000628:therapy*