title: Medial temporal N-acetyl-aspartate in pediatric major depression.
abstract: The medial temporal cortex (MTC) has been implicated in the pathogenesis of pediatric major depressive disorder (MDD). Eleven MDD case-control pairs underwent proton magnetic resonance spectroscopic imaging. N-acetyl-aspartate was lower in the left MTC (27%) in MDD patients versus controls. Lower N-acetyl-aspartate concentrations in MDD patients may reflect reduced neuronal viability.
authors.affiliation: Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
authors.forename: Frank P
authors.initials: FP
authors.lastname: MacMaster
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Moore
authors.forename: Aileen
authors.initials: A
authors.lastname: Russell
authors.forename: Yousha
authors.initials: Y
authors.lastname: Mirza
authors.forename: S Preeya
authors.initials: SP
authors.lastname: Taormina
authors.forename: Christian
authors.initials: C
authors.lastname: Buhagiar
authors.forename: David R
authors.initials: DR
authors.lastname: Rosenberg
mesh_terms: D000293:Adolescent; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D002648:Child; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D003865:Major Depressive Disorder / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline