Association between hypermutator phenotype, clinical variables, mucoid phenotype, and antimicrobial resistance in Pseudomonas aeruginosa.
The presence of hypermutator Pseudomonas aeruginosa was associated with poorer lung function in patients at the Adult West Midlands CF Unit. Mucoid isolates were more likely to be hypermutators. The presence of resistant mutant subpopulations was associated with hypermutator phenotype but was not good enough to be used as a test for this phenotype.
Waine
David J
DJ
Department of Biological Sciences, Warwick University, Coventry CV4 7AL, United Kingdom. djwaine@doctors.org.uk
Honeybourne
David
D
Smith
E Grace
EG
Whitehouse
Joanna L
JL
Dowson
Chris G
CG
D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis*; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D012372:ROC Curve; D012129:Respiratory Function Tests
D011135:Polysaccharides, Bacterial