[Comprehensive study on the risk factors of hepatitis B virus intrauterine infection].
OBJECTIVE
To study the risk factors of hepatitis B virus (HBV) intrauterine infection.


METHODS
Risk factors of HBV intrauterine infection were analyzed by nested case control study.


RESULTS
Data from univariate analysis revealed that risk factors of HBV intrauterine infection were positive results on HLA-DR3 (OR = 4.71, 1.62-13.66), HBV DNA (OR = 6.59, 2.72-15.97) and HBeAg (OR = 4.53, 1.93-10.64) in pregnant women, HLA-DR3 (OR = 3.91, 1.18-12.94) in newborn, HLA-I) R3 (OR = 5.96, 1.14-31.15) both in pregnant women and her newborns and HBV infection in placentas (OR = 2.51,1.12-5.60). Results from Multivariate unconditional logistics regression analysis showed that the risk factors of HBV intrauterine infection were positive in both HLA-DR3 (OR = 4.65, 1.44-15.05) and HBV DNA (OR = 6.56, 2.65-16.23) in pregnant women. However, there was no interaction between the two factors. The exposure rate of other factors did not reveal the difference in the two groups. With the increase of HBV DNA in pregnant women, the risk of HBV intrauterine infection was rising (chi2 = 16.74, P < 0.05).


CONCLUSIONS
Risk factors of HBV intrauterine infection were HLA-DR3 positive and HBV DNA positive in pregnant women but there was no interaction between the two factors. The risk of HBV intrauterine infection was increased along with the increase of HBV DNA in pregnant women.
Feng
Yong-Liang
YL
Department of Epidemiology, Shanxi Medical University, Taiyuan 030001, China.
Wang
Su-Ping
SP
Wei
Jun-Ni
JN
Shi
Xiao-Hong
XH
Zhang
Jun-Bin
JB
Guo
Qiong
Q
Wu
Xu-Biao
XB
Fan
Hua
H
Wang
Xiao-Fang
XF
D000328:Adult; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D015803:HLA-DR3 Antigen / Q000378:metabolism; D006509:Hepatitis B / Q000821:virology*; D006515:Hepatitis B virus / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D016015:Logistic Models; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D012307:Risk Factors
D004279:DNA, Viral; D015803:HLA-DR3 Antigen