title: Progression of a sessile serrated adenoma to an early invasive cancer within 8 months.
abstract: Recent studies suggest that serrated polyps, including hyperplastic polyps, traditional serrated adenomas, and sessile serrated adenomas, may be morphologically and genetically distinct and linked to microsatellite unstable colorectal cancers, and thus the concept of a hyperplastic polyp-serrate adenoma-carcinoma pathway has been suggested. Furthermore, it has been suggested that transformation from serrated polyps to invasive cancers can be rapid and occurs when the lesions are small; however, direct evidence for this issue is scant. We herein describe a case of a sessile serrated adenoma showing rapid transformation into a submucosal invasive carcinoma with remarkable morphological change in a short period of 8 months. This case is unique and suggestive, as it provided information about the natural history of a sessile serrated adenoma.
authors.affiliation: Department of Gastroenterology, Tokyo Metropolitan Tama Cancer Detection Center, Tokyo, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Oono
authors.forename: Kuangi
authors.initials: K
authors.lastname: Fu
authors.forename: Hisashi
authors.initials: H
authors.lastname: Nakamura
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Iriguchi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yamamura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tomino
authors.forename: Johji
authors.initials: J
authors.lastname: Oda
authors.forename: Masaru
authors.initials: M
authors.lastname: Mizutani
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takayanagi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kishi
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Shinohara
authors.forename: Kozo
authors.initials: K
authors.lastname: Yamada
authors.forename: Jun
authors.initials: J
authors.lastname: Matumoto
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Imamura
mesh_terms: D000236:Adenoma / Q000473:pathology*; D000368:Aged; D002277:Carcinoma / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D008297:Male; D013997:Time Factors