A comparative study to screen dementia and APOE genotypes in an ageing East African population.
Previous studies have established cross-cultural methods to screen for ageing- related dementia and susceptibility genes, in particular Alzheimer's disease (AD) among the Canadian Cree, African Americans and Yoruba in Nigeria. We determined whether the Community Screening Interview for Dementia (CSID), translated into Kikuyu, a major language of Kenya, could be used to evaluate dementia of the Alzheimer type. Using two sets of coefficients of cognitive and informant scores, two discriminant function (DF) scores were calculated for each of 100 elderly (>65 years) Nyeri Kenyans. When the cut-off points were selected for 100% sensitivities, the specificities of the DF scores were remarkably similar (93.75%) in the Kenyan sample. We propose the adapted CSID can be utilised to detect dementia among East Africans. We also show that apolipoprotein E epsilon 4 allele frequencies were high (approximately 30%) and not different between normal subjects and those with probable AD. There was no evidence to suggest years of education or vascular factors were associated with dementia status.
Chen
Chien-Hsiun
CH
Laboratory of Neurogeriatrics, Department of Neurology and Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Mizuno
Toshiki
T
Elston
Robert
R
Kariuki
Monica M
MM
Hall
Kathleen
K
Unverzagt
Fred
F
Hendrie
Hugh
H
Gatere
Samuel
S
Kioy
Paul
P
Patel
Nilesh B
NB
Friedland
Robert P
RP
Kalaria
Raj N
RN
D000351:Africa, Eastern; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D000483:Alleles; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D044383:Black People / Q000235:genetics; D003704:Dementia / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D005828:Genetics, Population; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010865:Pilot Projects; D018709:Statistics, Nonparametric; D001741:Black or African American
D001057:Apolipoproteins E