Safety of a novel treatment to improve sperm motility in men with spinal cord injury.
Seminal plasma of men with spinal cord injury (SCI) contains high concentrations of cytokines. Neutralizing these target cytokines did not damage sperm DNA or sperm viability, indicating that this method may hold promise as a safe therapy for improving sperm motility in men with SCI.
Ibrahim
Emad
E
Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida 33136, USA. e.ibrahim@miami.edu
Brackett
Nancy L
NL
Aballa
Teodoro C
TC
Lynne
Charles M
CM
D000911:Antibodies, Monoclonal / Q000494:pharmacology; D002470:Cell Survival / Q000502:physiology; D016207:Cytokines / Q000276:immunology; D053938:DNA Fragmentation / Q000187:drug effects; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000628:therapy*; D008297:Male; D018121:Receptors, Cytokine / Q000037:antagonists & inhibitors; D027724:Reproductive Techniques, Assisted; D012965:Sodium Chloride / Q000494:pharmacology; D013081:Sperm Motility / Q000187:drug effects / Q000502:physiology*; D013094:Spermatozoa / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000150:complications / Q000503:physiopathology*
D000911:Antibodies, Monoclonal; D016207:Cytokines; D018121:Receptors, Cytokine; D012965:Sodium Chloride