The CorA Mg2+ channel is required for the virulence of Salmonella enterica serovar typhimurium.
CorA is the primary Mg(2+) channel in Salmonella enterica serovar Typhimurium. A corA mutant is attenuated in mice and defective for invasion of and replication within epithelial cells. Microarray studies show that several virulence effectors are repressed in a corA mutant strain, which ultimately manifests itself as a decrease in virulence.
Papp-Wallace
Krisztina M
KM
Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4965, USA. kmp12@po.cwru.edu
Nartea
Margaret
M
Kehres
David G
DG
Porwollik
Steffen
S
McClelland
Michael
M
Libby
Stephen J
SJ
Fang
Ferric C
FC
Maguire
Michael E
ME
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D015153:Blotting, Western; D018938:Caco-2 Cells; D027682:Cation Transport Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008274:Magnesium / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D020411:Oligonucleotide Array Sequence Analysis; D012481:Salmonella Infections, Animal / Q000382:microbiology; D012486:Salmonella typhimurium / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins; D027682:Cation Transport Proteins; C072716:CorA protein, Salmonella; D008274:Magnesium