title: Molecular structural characteristics of estrogen receptor modulators as determinants of estrogen receptor selectivity.
abstract: This review will discuss the structural determinants and requirements necessary for estrogen receptors alpha and beta selectivity and ligand-receptor binding affinity. In addition, strategies likely to result in the development of a pharmacophore model that account for the differences in estrogenic effects between different ligands will be discussed.
authors.affiliation: School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Agatonovic-Kustrin
authors.forename: J V
authors.initials: JV
authors.lastname: Turner
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D020847:Estrogen Receptor Modulators / Q000494:pharmacology*; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D004967:Estrogens / Q000737:chemistry; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D011487:Protein Conformation; D011725:Pyridines / Q000737:chemistry; D011960:Receptors, Estrogen / Q000378:metabolism*; D012984:Software; D013329:Structure-Activity Relationship; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: C506487:ESR1 protein, human; D020847:Estrogen Receptor Modulators; D047628:Estrogen Receptor alpha; D004967:Estrogens; D008024:Ligands; D011725:Pyridines; D011960:Receptors, Estrogen