title: Caititu: a tool to graphically represent peptide sequence coverage and domain distribution.
abstract: Here we present Caititu, an easy-to-use proteomics software to graphically represent peptide sequence coverage and domain distribution for different correlated samples (e.g. originated from 2D gel spots) relatively to the full-sequence of the known protein they are related to. Although Caititu has a broad applicability, we exemplify its usefulness in Toxinology using snake venom as a model. For example, proteolytic processing may lead to inactivation or loss of domains. Therefore, our proposed graphic representation for peptides identified by two dimensional electrophoresis followed by mass spectrometric identification of excised spots can aid in inferring what kind of processing happened to the toxins, if any. Caititu is freely available to download at: http://pcarvalho.com/things/caititu.
authors.affiliation: Systems Engineering and Computer Science Program, COPPE, Federal University of Rio de Janeiro, Brazil.
authors.forename: Paulo C
authors.initials: PC
authors.lastname: Carvalho
authors.forename: Magno
authors.initials: M
authors.lastname: Junqueira
authors.forename: Richard H
authors.initials: RH
authors.lastname: Valente
authors.forename: Gilberto B
authors.initials: GB
authors.lastname: Domont
mesh_terms: D000595:Amino Acid Sequence; D011506:Proteins / Q000032:analysis* / Q000737:chemistry*; D012985:Software Design
chemical_list: D011506:Proteins