title: The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb1 by heat processing.
abstract: The chemical and hydroxyl radical (*OH) scavenging activity changes of ginsenoside Rb(1) (Rb(1)) by heat processing were investigated in this study. Rb(1) was changed into 20(S)-Rg(3), 20(R)-Rg(3), Rk(1), and Rg(5) by heat processing through glucosyl elimination and epimerization of carbon-20 by SN1 reaction. The glucosyl moiety, separated from Rb(1), made Maillard reaction product (MRPs) with glycine. The generations of 20(S)-Rg(3) and MRPs were related to the increased OH scavenging activity of Rb(1) by heat processing.
authors.affiliation: Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Shillim-Dong San 56-1, Seoul 151-742, Republic of Korea.
authors.forename: Yong Jae
authors.initials: YJ
authors.lastname: Lee
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Kim
authors.forename: Ki Sung
authors.initials: KS
authors.lastname: Kang
authors.forename: Jin Gyun
authors.initials: JG
authors.lastname: Lee
authors.forename: Takako
authors.initials: T
authors.lastname: Yokozawa
authors.forename: Jeong Hill
authors.initials: JH
authors.lastname: Park
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000494:pharmacology; D036145:Ginsenosides / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry; D005998:Glycine / Q000737:chemistry; D006358:Hot Temperature; D017665:Hydroxyl Radical; D008027:Light; D015416:Maillard Reaction; D008956:Models, Chemical; D005894:Panax / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D013481:Superoxides
chemical_list: D016166:Free Radical Scavengers; D036145:Ginsenosides; D010936:Plant Extracts; D013481:Superoxides; D017665:Hydroxyl Radical; C442759:ginsenoside Rb1; D005947:Glucose; D005998:Glycine