title: Evaluation of methods for rapid detection of resistance to isoniazid and rifampin in Mycobacterium tuberculosis isolates collected in the Caribbean.
abstract: The rapid identification of drug-resistant strains of Mycobacterium tuberculosis is crucial for the timely initiation of appropriate antituberculosis therapy. The performance of the Genotype MTBDRplus assay was compared with that of the Bactec 460 TB system, a "gold standard" culture-based method. The Genotype MTBDRplus assay was quicker and more cost-effective for the detection of rifampin resistance, but it was not as good for the detection of isoniazid-resistant strains in our setting.
authors.affiliation: Department of Para-Clinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad & Tobago. Patrick.Akpaka@sta.uwi.edu
authors.forename: Patrick Eberechi
authors.initials: PE
authors.lastname: Akpaka
authors.forename: Shirematee
authors.initials: S
authors.lastname: Baboolal
authors.forename: Denise
authors.initials: D
authors.lastname: Clarke
authors.forename: Lorraine
authors.initials: L
authors.lastname: Francis
authors.forename: Nalin
authors.initials: N
authors.lastname: Rastogi
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D017691:Caribbean Region; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000191:economics / Q000379:methods; D025202:Molecular Diagnostic Techniques / Q000191:economics / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D012293:Rifampin / Q000494:pharmacology*; D013997:Time Factors; D014376:Tuberculosis / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents; D004269:DNA, Bacterial; D007538:Isoniazid; D012293:Rifampin