title: Platelet gel for the surgical treatment of onychocryptosis.
abstract: BACKGROUND
  The growth factors derived from platelets contained in platelet-rich plasma comprise a series of molecules that favor the production of collagen with the proliferation of fibroblasts and new blood vessels. These substances exert their effect on the cells, acting in all the stages of cicatrization, especially in hemostasis and early fibroplasia.
  
  
  METHODS
  Thirty-five patients (70 feet) were selected, operated on both sides for ingrown hallux nails, and subjected to two different experimental conditions in a crossover clinical trial with positive control of treatment. Two main variables were analyzed: on one side, the bleeding, according to three preestablished categories, and on the other, the mean time of cicatrization in days.
  
  
  RESULTS
  Significant differences (P < .001) were found between the two groups for bleeding. We observed that cicatrization time did not differ significantly between the two treatments.
  
  
  CONCLUSIONS
  The use of platelet gel for the treatment of onychocryptosis by single nonincisional matricectomy can guarantee good hemostasis, with a significant reduction in bleeding, but does not produce a clinically significant reduction in cicatrization time.
authors.affiliation: Department of Podiatry, Seville University, Seville, Spain. acordoba@us.es
authors.forename: Antonio
authors.initials: A
authors.lastname: Córdoba-Fernandez
authors.forename: Rafael
authors.initials: R
authors.lastname: Rayo-Rosado
authors.forename: José María
authors.initials: JM
authors.lastname: Juarez-Jiménez
mesh_terms: D000328:Adult; D001792:Blood Platelets; D049109:Cell Proliferation; D002921:Cicatrix; D018592:Cross-Over Studies; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005782:Gels; D006133:Growth Substances; D006214:Hallux; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009263:Nails, Ingrown / Q000601:surgery*; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage*; D053657:Platelet-Rich Plasma; D016037:Single-Blind Method
chemical_list: D005782:Gels; D006133:Growth Substances; D010982:Platelet-Derived Growth Factor