Alpha,beta-D-CNA induced rigidity within oligonucleotides.
Introduction of alpha,beta-D-CNA featuring canonical values of the torsional angles alpha and beta within oligonucleotides leads to an overall stabilization and improved rigidity of the duplex DNA as demonstrated by UV experiments, circular dichroism and corroborated by molecular dynamics simulations.
Dupouy
Christelle
C
Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique UMR 5068 CNRS, Université Paul Sabatier, 31062, Toulouse Cedex 9, France.
Iché-Tarrat
Nathalie
N
Durrieu
Marie-Pierre
MP
Vigroux
Alain
A
Escudier
Jean-Marc
JM
D008958:Models, Molecular; D009696:Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D013237:Stereoisomerism
D009696:Nucleic Acids; D009841:Oligonucleotides