Control of massive bleeding in dengue hemorrhagic fever with severe thrombocytopenia by use of intravenous anti-D globulin.
Dengue hemorrhagic fever (DHF) is a potentially lethal complication of mosquito borne viral disease, Dengue Fever. Thrombocytopenia is a constant finding in DHF/Dengue Shock Syndrome (DSS). We report two cases that fulfilled the WHO criteria of DSS: high fever, positive tourniquet test, severe thrombocytopenia (<10,000/mm(3)), hemo-concentration (Hematocrit increase >20%), hypotension and bleeding refractory to routine therapeutic measures, who showed dramatic improvement after receiving Intravenous Anti-D globulin (IV anti-D).
Yadav
Satya P
SP
Pediatric Hematology and Oncology Unit, Department of Pediatrics, Center for Child Health, Sir Ganga Ram Hospital, New Delhi, India. satya_1026@hotmail.com
Sachdeva
Anupam
A
Gupta
Dhiren
D
Sharma
Sunil D
SD
Kharya
Gaurav
G
D000293:Adolescent; D002675:Child, Preschool; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008171:Lung Diseases / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D018029:Rho(D) Immune Globulin / Q000627:therapeutic use*; D019595:Severe Dengue / Q000150:complications*; D013921:Thrombocytopenia / Q000150:complications*
D007155:Immunologic Factors; D018029:Rho(D) Immune Globulin