title: Malignant lymphoma without lymphadenopathy.
abstract: Hepatosplenic T-Cell lymphoma (HSTCL) is a rare form of extra-nodal post-thymic T-cell non-Hodgkin's lymphoma that primarily involves liver and spleen with B symptoms, with a characteristic absence of lymphadenopathy. We report such an entity in a 65-year-old man who was diagnosed to have multiple myeloma and treated for the same for two years. A clinical diagnosis of secondary myelofibrosis was suspected and was investigated, when he developed pancytopenia and massive hepatosplenomegaly at one of his follow-up visits. The patient underwent therapeutic splenectomy with a simultaneous wedge biopsy of the liver and with their corresponding histopathological and immunohistochemical features, the diagnosis of HSTCL was clinched.
authors.affiliation: Department of Pathology, St. John's Medical College and Hospital, Bangalore 560 034.
authors.forename: Usha
authors.initials: U
authors.lastname: Kini
authors.forename: Betty
authors.initials: B
authors.lastname: Alexander
authors.forename: Marjorie
authors.initials: M
authors.lastname: Correa
mesh_terms: D000368:Aged; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008297:Male; D009101:Multiple Myeloma / Q000175:diagnosis / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D013154:Spleen / Q000473:pathology; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery