title: Urinary mercury and biomarkers of early renal dysfunction in environmentally and occupationally exposed adults: a three-country study.
abstract: We conducted a cross-sectional study in Sweden, Italy and Poland to assess environmental and occupational exposure to mercury from chloralkali (CA) plants and the potential association with biomarkers of early renal dysfunction. Questionnaire data and first-morning urine samples were collected from 757 eligible subjects. Urine samples were analysed for mercury corrected for creatinine (U-HgC), alpha-1-microglobulin (A1M), N-acetyl-beta-glucosaminidase (NAG) and albumin. Determinants of urinary mercury excretion were examined. Levels of kidney markers were compared in three U-HgC categories, and differences were tested taking age and other covariates into account. In the general population, the median U-HgC was higher in Italian (1.2 microg/gC) than in Polish (0.22 microg/gC) or Swedish (0.21 microg/gC) subjects, and no effect of living close to CA plants could be shown. Dental amalgam, chewing on amalgam, and fish consumption were positively associated with U-HgC. In subjects from the general population, no effects on the kidney markers could be detected, while in men, including workers occupationally exposed to mercury, U-HgC was positively associated with the kidney markers, especially with NAG, but to some extent also with A1M and albumin. Differences in urinary mercury and kidney markers in the general population between three studied countries could possibly be due to dietary factors, increased susceptibility to mercury at low selenium intake or co-exposure to other nephrotoxic metals.
authors.affiliation: Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland. dorota.jarosinska@eea.europa.eu
authors.forename: Dorota
authors.initials: D
authors.lastname: Jarosińska
authors.forename: Milena
authors.initials: M
authors.lastname: Horvat
authors.forename: Gerd
authors.initials: G
authors.lastname: Sällsten
authors.forename: Barbara
authors.initials: B
authors.lastname: Mazzolai
authors.forename: Beata
authors.initials: B
authors.lastname: Dabkowska
authors.forename: Adam
authors.initials: A
authors.lastname: Prokopowicz
authors.forename: Marek
authors.initials: M
authors.lastname: Biesiada
authors.forename: Lars
authors.initials: L
authors.lastname: Barregård
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis*; D004785:Environmental Pollutants / Q000633:toxicity / Q000652:urine*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007674:Kidney Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000652:urine*; D008628:Mercury / Q000633:toxicity / Q000652:urine*; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000652:urine*; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D008628:Mercury