title: Evaluation of postoperative drainage with application of platelet-rich and platelet-poor plasma following hemithyroidectomy: a randomized controlled clinical trial.
abstract: BACKGROUND
  Platelet-rich plasma (PRP) and platelet-poor plasma (PPP) have been used to improve hemostasis and wound healing after surgery; however, randomized controlled trials proving their efficacy are lacking.
  
  
  METHODS
  Hemithyroidectomy was performed on 52 patients. Autologous PRP and PPP were applied during wound closure in the treatment group, while saline was applied in the controls. Outcome measures were postoperative drainage, pain, analgesic use, and length of hospital stay.
  
  
  RESULTS
  The 24-hour cumulative drainage was reduced by 29.3% in the treatment group (44.9 mL vs 63.5 mL, p = .039). The treatment group required less analgesic medication despite similar pain scores; however, the difference was not significant. There was a trend toward decreased length of stay for the PRP/PPP group (p = .059).
  
  
  CONCLUSIONS
  Hemithyroidectomy served as a stringent test to evaluate the wound-healing capacity of platelet-rich and platelet-poor plasma. This study provides evidence that PRP and PPP reduced postoperative drainage in soft-tissue surgery.
authors.affiliation: London Health Sciences Center, University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada. John.Yoo@lhsc.on.ca
authors.forename: John
authors.initials: J
authors.lastname: Yoo
authors.forename: Kathryn
authors.initials: K
authors.lastname: Roth
authors.forename: Brian
authors.initials: B
authors.lastname: Hughes
authors.forename: Kevin
authors.initials: K
authors.lastname: Fung
authors.forename: Jason
authors.initials: J
authors.lastname: Franklin
authors.forename: Howard
authors.initials: H
authors.lastname: Lampe
authors.forename: William S
authors.initials: WS
authors.lastname: Pietrzak
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001804:Blood Transfusion, Autologous / Q000379:methods; D004322:Drainage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario; D017713:Platelet Transfusion; D053657:Platelet-Rich Plasma; D011184:Postoperative Period; D011446:Prospective Studies; D013965:Thyroidectomy / Q000379:methods*; D016896:Treatment Outcome