The efficacy of Biobon and Ostim within metaphyseal defects using the Göttinger Minipig.
BACKGROUND
To compare bio, osteocompatibility, rate of resorption and remodeling dynamics of two clinically used bone substitutes.


METHODS
In a randomized fashion Biobon and Ostim were implanted bilaterally into the proximal metaphyseal tibiae of 18 Göttinger Minipigs in a direct right versus left "intra-individual" comparison. Fluorescent labelling was used. Microradiographic, histological and morphometric evaluation was carried out at 6, 12 and 52 weeks.


RESULTS
Both bone substitutes showed good biocompatibility, bioactivity and osteoconductivity. The degradation dynamics of both materials differed. Degradation of Ostim stopped after 6 weeks postoperatively, whereas Biobon was degraded slowly but evenly over the time intervals. Only at 6 weeks a significant (P < 0.05) difference in resorption rate was detected. Both Biobon and Ostim showed incomplete resorption after a year.


CONCLUSIONS
After 1 year no "restitutio ad integrum" could be observed in either group. Similar to ceramics, a thorough osseous incorporation seemed to inhibit further degradation of both bone substitute materials.
Spies
Christian K G
CK
Klinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Aachen, Pauwelsstr. 30, 52074, Aachen, Germany. christianspies1@gmx.net
Schnürer
Stefan
S
Gotterbarm
Tobias
T
Breusch
Steffen
S
D000818:Animals; D018786:Bone Substitutes; D008422:Materials Testing; D016348:Osseointegration; D013552:Swine; D013556:Swine, Miniature
D018786:Bone Substitutes