Colonic adenoma with squamous metaplasia.
Squamous metaplasia arising within colon adenomas is a rare occurrence, with a 0.4% incidence noted predominantly in elderly males. A case of squamous metaplasia arising in a tubulovillous adenoma of the cecum, associated with adenocarcinoma, is described. Squamous metaplasia was immunoreactive for beta-catenin, but negative for cytokeratin 20, CDX2, p63, estrogen receptor, progesterone receptor, p16, and human papilloma virus. Squamous differentiation may serve as a precursor lesion for squamous neoplasia of the colorectum.
Pantanowitz
Liron
L
Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, Massachusetts 01199, USA. Liron.pantanowitz@bhs.org
D000230:Adenocarcinoma / Q000473:pathology; D000236:Adenoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D003082:Colectomy; D003110:Colonic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008679:Metaplasia / Q000473:pathology / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology; D051176:beta Catenin / Q000032:analysis
D014408:Biomarkers, Tumor; D051176:beta Catenin