title: Radiation-induced intra- and extra-cranial high-grade myxofibrosarcoma with tumor bleeding.
abstract: Radiation-induced secondary malignant neoplasms in central nervous system tumor survivors have become a problem of increasing concern over the last 20 years because of rare but serious and potentially fatal complications. Herein, we report the case of a 28-year-old man who presented with a left fronto-temporal intra- and extra-cranial tumor with intra-tumor bleeding at the site of previous radiotherapy in May 1991. He underwent craniotomy with gross total removal of the tumor and surrounding hematoma in August 2005. The tumor was a high-grade malignant myxofibrosarcoma (Fédération Nationale des Centres de Lutte Contre le Cancer Grade III [out of III]). Radiation-induced malignant myxofibrosarcoma with tumor bleeding is an infrequent complication of radiotherapy. Although rare, it should always be kept in mind with regards to the differential diagnosis of a lesion that develops several years after radiation therapy. Also, follow-up of patients that have undergone radiation therapy should be long-term.
authors.affiliation: Department of Neurosurgery, Chi-Mei Medical Center, #901 Chung Hwa Road, Yung Kang City, Tainan, Taiwan 710.
authors.forename: Jinn-Rung
authors.initials: JR
authors.lastname: Kuo
authors.forename: Chung-Ching
authors.initials: CC
authors.lastname: Chio
authors.forename: Che-Chuan
authors.initials: CC
authors.lastname: Wang
authors.forename: Yueh-Hsin
authors.initials: YH
authors.lastname: Chu
authors.forename: Kao-Chang
authors.initials: KC
authors.lastname: Lin
authors.forename: Shin-Sung
authors.initials: SS
authors.lastname: Chuang
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000473:pathology / Q000601:surgery; D001932:Brain Neoplasms / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D002543:Cerebral Hemorrhage / Q000150:complications / Q000601:surgery; D005354:Fibrosarcoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D018237:Germinoma / Q000150:complications / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008297:Male; D009236:Myxosarcoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D009381:Neoplasms, Radiation-Induced / Q000150:complications / Q000473:pathology* / Q000601:surgery; D011878:Radiotherapy / Q000009:adverse effects; D016896:Treatment Outcome