[Statins and their pleiotropic effects].
Statins are well-established and effective drugs in the treatment of hyperlipidemias and coronary heart disease. However the effects of statins extend beyond their lipid-lowering actions, due to their capacity to inhibit prenylation of some intracellular regulatory proteins. Recent studies have shown that statins could modulate inflammantory response, improve endothelial function, exert antiarrhytmic properties, have beneficial effects on renal function and bone tissue. Statins may exert effect in the treament and prevention of dementia and some autoimmune disorders. Although statins therapy is generally well-tolerated, sometimes they lead to objective adverse effects, mainly in muscular system. Combination therapy with fibrates, coenzyme Q and other substances may increase and even extend therapeutic effects of statins. Further studies will help to clarify the clinical role of statins.
Galus
Ryszard
R
Warszawski Uniwrsytet Medyczny, Katedra i Zakład Histologii i Embriologii Centrum Biostruktury. rgalus@ib.amwaw.edu.pl
Zandecki
Łukasz
Ł
Jóźwiak
Jarosław
J
Włodarski
Krzysztof
K
D001327:Autoimmune Diseases / Q000517:prevention & control; D003327:Coronary Disease / Q000188:drug therapy*; D003704:Dementia / Q000517:prevention & control; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000188:drug therapy*; D009140:Musculoskeletal Diseases / Q000139:chemically induced
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors