Lung transplantation for cystic fibrosis: ten years of experience.
Lung transplantation represents the only therapeutic option for patients affected by end-stage cystic fibrosis (CF). We performed 76 lung transplantations in 73 patients from 1996-2007. The mean time on the waiting list was 10+/-6 months. The median follow-up after the transplantation was 69.3 months. Twenty-one transplants (27.6%) were performed under cardiopulmonary bypass. Perioperative mortality, excluding retransplants, was 16.4% (12 patients) and the causes of death were sepsis, primary graft failure, and myocardial infarction. The overall survival was 74.5%+/-5%, 62.9%+/-5%, 54.1%+/-6%, and 43.4%+/-6% at 1, 3, 5, and 10 years, respectively. The accurate selection of potential recipients and the correct timing of referral and transplantation are factors that play crucial roles to obtain satisfactory results in term of improvement of quality of life and long-term survival.
Aratari
M T
MT
Department of Thoracic Surgery, University of Rome La Sapienza, Rome, Italy. aratarim@libero.it
Venuta
F
F
De Giacomo
T
T
Rendina
E A
EA
Anile
M
M
Diso
D
D
Francioni
F
F
Quattrucci
S
S
Rolla
M
M
Pugliese
F
F
Liparulo
V
V
Di Stasio
M
M
Ricella
C
C
Tsagkaropoulos
S
S
Ferretti
G
G
Coloni
G F
GF
D000293:Adolescent; D000328:Adult; D002648:Child; D003550:Cystic Fibrosis / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006085:Graft Survival; D006801:Humans; D016040:Lung Transplantation / Q000401:mortality / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D016019:Survival Analysis; D014850:Waiting Lists