title: Double dissociation of pharmacologically induced deficits in visual recognition and visual discrimination learning.
abstract: Monkeys trained in either one-trial recognition at 8- to 10-min delays or multi-trial discrimination habits with 24-h intertrial intervals received systemic cholinergic and dopaminergic antagonists, scopolamine and haloperidol, respectively, in separate sessions. Recognition memory was impaired markedly by scopolamine but not at all by haloperidol, whereas habit formation was impaired markedly by haloperidol but only minimally by scopolamine. These differential drug effects point to differences in synaptic modification induced by the two neuromodulators that parallel the contrasting properties of the two types of learning, namely, fast acquisition but weak retention of memories versus slow acquisition but durable retention of habits.
authors.affiliation: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, USA. turchij@mail.nih.gov
authors.forename: Janita
authors.initials: J
authors.lastname: Turchi
authors.forename: Deanne
authors.initials: D
authors.lastname: Buffalari
authors.forename: Mortimer
authors.initials: M
authors.lastname: Mishkin
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D018680:Cholinergic Antagonists / Q000494:pharmacology; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008253:Macaca mulatta; D008297:Male; D021641:Recognition, Psychology / Q000187:drug effects / Q000502:physiology*; D012601:Scopolamine / Q000494:pharmacology; D014796:Visual Perception / Q000187:drug effects / Q000502:physiology*
chemical_list: D018680:Cholinergic Antagonists; D018492:Dopamine Antagonists; D012601:Scopolamine; D006220:Haloperidol