title: Tubuloreticular structures in different types of myositis: implications for pathogenesis.
abstract: In dermatomyositis (DM) there is strong histopathological evidence of a microvascular pathogenesis, including endothelial microtubular inclusions. In nonspecific myositis, perimysial and perivascular infiltrates in the muscle biopsy similar to DM are found. Microtubular inclusions in endothelial cells were systematically searched for and found in 4 of the 20 muscle biopsies of nonspecific myositis patients (20%). Three had a CTD (SLE, scleroderma, and Sjogren syndrome). Ten patients with DM and 5 patients with sporadic inclusion body myositis served as positive and negative controls, respectively.
authors.affiliation: Department of Neurology, Flevoziekenhuis, Almere, The Netherlands.
authors.forename: Irene M
authors.initials: IM
authors.lastname: Bronner
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Hoogendijk
authors.forename: Henk
authors.initials: H
authors.lastname: Veldman
authors.forename: Marja
authors.initials: M
authors.lastname: Ramkema
authors.forename: Marius A
authors.initials: MA
authors.lastname: van den Bergh Weerman
authors.forename: Annemieke J M
authors.initials: AJ
authors.lastname: Rozemuller
authors.forename: Marianne
authors.initials: M
authors.lastname: de Visser
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000473:pathology; D001706:Biopsy; D002196:Capillaries / Q000648:ultrastructure; D003882:Dermatomyositis / Q000473:pathology*; D004730:Endothelium, Vascular / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008179:Lupus Erythematosus, Discoid / Q000473:pathology; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008870:Microtubules / Q000648:ultrastructure*; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000473:pathology; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000473:pathology; D012595:Scleroderma, Systemic / Q000473:pathology; D012859:Sjogren's Syndrome / Q000473:pathology