title: Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae).
abstract: The methanolic extract of the whole plant of Echium glomeratum Poir. (Boraginaceae) has afforded five pyrrolizidine alkaloids, three that were (7S, 8R)-petranine (1), (7S, 8S)-petranine (2), and (7R, 8R)-petranine (3a) or (7R, 8S)-petranine (3b), comprising a tricyclic pyrrolizidine alkaloids subclass; and two that were known but to the species: 7-angeloylretronecine (4) and 9-angeloylretronecine (5). All compounds were tested against a human tumor panel for cytotoxicity; no activity was observed (EC50 values>20microg/ml).
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan. falali@just.edu.jo
authors.forename: Feras Q
authors.initials: FQ
authors.lastname: Alali
authors.forename: Yahya R
authors.initials: YR
authors.lastname: Tahboub
authors.forename: Eyad S
authors.initials: ES
authors.lastname: Ibrahim
authors.forename: Amjad M
authors.initials: AM
authors.lastname: Qandil
authors.forename: Khaled
authors.initials: K
authors.lastname: Tawaha
authors.forename: Jason P
authors.initials: JP
authors.lastname: Burgess
authors.forename: Arlene
authors.initials: A
authors.lastname: Sy
authors.forename: Yuka
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: David J
authors.initials: DJ
authors.lastname: Kroll
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: Oberlies
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification; D036661:Echium / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D001688:Biological Products; D010936:Plant Extracts; D011763:Pyrrolizidine Alkaloids