Evolution of maxillofacial brown tumors after parathyroidectomy in primary hyperparathyroidism.
BACKGROUND
Brown tumor occasionally affects the facial bones. Clinically, these lesions can be mistaken for a neoplasm. Opinions are divided on the course of management of the bony lesions once parathyroidectomy has been carried out.


METHODS
We treated 22 patients with primary hyperparathyroidism and osteitis fibrosa cystica and observed their clinical and biochemical recovery.


RESULTS
Fifteen patients (68.2%) had brown tumors in mandible, and 7 (31.8%) in maxilla. After parathyroidectomy, 21 patients had normal total serum calcium values. All brown tumors presented a spontaneous progressive regression; in 18 cases, regression was total, with a mean time period of 10 months. Two patients had partial regression after nearly 2 years. Another 2 patients were lost to follow-up.


CONCLUSIONS
After successful parathyroid surgery, the bony lesions tended to regress spontaneously, either partially or completely. However, if the lesion is disfiguring or symptomatic, surgical excision may be indicated.
Reséndiz-Colosia
Jaime Alonso
JA
Department of Head and Neck Surgery, Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico. jaimearc@cablevision.net.mex
Rodríguez-Cuevas
Sergio Arturo
SA
Flores-Díaz
Rutilio
R
Juan
Martín Hernández-San
MH
Gallegos-Hernández
José Francisco
JF
Barroso-Bravo
Sinhué
S
Gómez-Acosta
Fernando
F
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000150:complications / Q000534:rehabilitation* / Q000601:surgery*; D008297:Male; D008334:Mandible / Q000473:pathology; D008437:Maxilla / Q000473:pathology; D008875:Middle Aged; D010002:Osteitis Fibrosa Cystica / Q000097:blood / Q000209:etiology / Q000534:rehabilitation*; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D010758:Phosphorus / Q000097:blood; D020127:Recovery of Function; D012189:Retrospective Studies; D016896:Treatment Outcome
D015415:Biomarkers; D010281:Parathyroid Hormone; D010758:Phosphorus; D002118:Calcium