title: Effects of a casein hydrolysate prepared from Aspergillus oryzae protease on adjuvant arthritis in rats.
abstract: We evaluated the effects of a casein hydrolysate (CH) prepared from Aspergillus oryzae protease on rat adjuvant arthritis, a model of human rheumatoid arthritis. CH was administered orally once a day to the animals for 22 d after the adjuvant injection. CH suppressed swelling in the adjuvant-uninjected hind paws, and a higher dose of CH suppressed the increase in arthritic score and swelling of the adjuvant-injected hind paws. A histopathological examination revealed evidence that the higher dose of CH suppressed the articular changes in the rats. In addition, CH suppressed the production of nitric oxide and prostaglandin E(2) in the plasma of the rats. These results suggest that CH had a suppressive effect on adjuvant arthritis by inhibiting the acute and chronic inflammatory reactions.
authors.affiliation: R and D Center, Calpis Co., Ltd., Sagamihara-shi, Kanagawa, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Hatori
authors.forename: Kohji
authors.initials: K
authors.lastname: Ohki
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Hirano
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Yang
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kuboki
authors.forename: Chiyuki
authors.initials: C
authors.lastname: Abe
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D001236:Aspergillus oryzae / Q000235:genetics / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002364:Caseins / Q000096:biosynthesis / Q000235:genetics / Q000627:therapeutic use; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D007052:Ibuprofen / Q000627:therapeutic use; D009569:Nitric Oxide / Q000096:biosynthesis; D051381:Rats
chemical_list: D002364:Caseins; D009569:Nitric Oxide; C475729:casein hydrolysate; D015232:Dinoprostone; D007052:Ibuprofen