title: [Cutaneous lupus induced by etanercept in rheumatoid arthritis].
abstract: Therapy with anti-TNFalpha in rheumatoid arthritis may induce autoimmune disorders. Induction of autoantibodies is frequently observed, but lupus-like syndrome is rare and few cases only have been reported. We report a 41-year-old female, treated with etanercept for a rheumatoid arthritis, who developed a cutaneous lupus induced without any other organ involvement, associated with high ANA and DNA antibody titres. The skin biopsy and the histological analysis with immunofluorescence confirmed the diagnosis. The anti-TNFalpha treatment was stopped. Corticosteroids were increased and hydroxychloroquine administered because skin lesions persist after three months.
authors.affiliation: Service de rhumatologie, hôpital El-Ayachi, CHU de Rabat-Salé, 10000 Rabat-Salé, Maroc. abourazakf@yahoo.fr
authors.forename: F E
authors.initials: FE
authors.lastname: Abourazzak
authors.forename: P
authors.initials: P
authors.lastname: Guggenbuhl
authors.forename: A
authors.initials: A
authors.lastname: Perdriger
authors.forename: J
authors.initials: J
authors.lastname: Meadeb
authors.forename: N
authors.initials: N
authors.lastname: Gando-Cocley
authors.forename: J
authors.initials: J
authors.lastname: Chevrant-Breton
authors.forename: N
authors.initials: N
authors.lastname: Hajjaj-Hassouni
authors.forename: G
authors.initials: G
authors.lastname: Chalès
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D000068800:Etanercept; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects*; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced*; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D018501:Antirheumatic Agents; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D000068800:Etanercept