title: Circulating interleukin-18 concentrations and a loss-of-function P2X7 polymorphism in heart failure.
abstract: We examined if a loss-of-function polymorphism in the P2X(7) receptor (1513C) corresponded with circulating interleukin(IL)-18 concentrations in heart failure (HF) patients. IL-18 values were significantly elevated in HF subjects compared to healthy control subjects. No association was seen between the polymorphism and IL-18 concentrations in HF patients. In HF patients, IL-18 values had an inverse relationship with ejection fraction, mean arterial pressure and body mass index, while high IL-18 concentrations were associated with increased mortality.
authors.forename: Guy D
authors.initials: GD
authors.lastname: Eslick
authors.forename: Binu V
authors.initials: BV
authors.lastname: Thampan
authors.forename: Marek
authors.initials: M
authors.lastname: Nalos
authors.forename: Anthony S
authors.initials: AS
authors.lastname: McLean
authors.forename: Ronald
authors.initials: R
authors.lastname: Sluyter
mesh_terms: D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000235:genetics*; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011110:Polymorphism, Genetic / Q000235:genetics*; D018048:Receptors, Purinergic P2 / Q000235:genetics*; D058486:Receptors, Purinergic P2X7
chemical_list: D020382:Interleukin-18; C546468:P2RX7 protein, human; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7