[Clinical analysis of childhood acute generalized exanthematous pustulosis].
OBJECTIVE
To describe the etiology, clinical features and treatment of childhood acute generalized exanthematous pustulosis (AGEP).


METHODS
Clinical data from 20 cases of childhood acute generalized exanthematous pustulosis from 1990 to 2008 were retrospectively reviewed.


RESULTS
Eighteen cases had a history of medication, including the use of penicillin (n=6), cephalosporins (n=3), sulphonamides (n=2), algopyrin (n=2), vaccines (n=2 ) and anti-cold drugs (n=3). Fever and generalized erythematous pustules were observed in all 20 cases. Histopathologic examination revealed spongiform superficial pustules and papillary edema. The patients were asked to stop taking suspected sensitizing drugs and received glucocorticoid treatment (1-2 mg/kg daily). After 3-5 days of the treatment, symptoms were improved and the dosage of glucocorticoid was gradually reduced. All patients were healed within 20 days after treatment.


CONCLUSIONS
The cause of AGEP is mainly attributed to the use of antibiotics, sulphonamides, antipyretic analgesics and vaccines in children. AGEP is characterized by fever and widespread pustular eruption of the skin. Removal of sensitizing factors and glucocorticoid administration is important in the treatment of AGEP in children.
Zhang
Jiang-Lin
JL
Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China. jianglin_zhang@yahoo.com
Chen
Xiang
X
Li
Ji
J
Xie
Hong-Fu
HF
D002648:Child; D002675:Child, Preschool; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005076:Exanthema / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy