title: Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system.
abstract: Sphingolipids were once regarded as inert structural components of cell membranes. Now these metabolites are generally believed to be important bioactive molecules that control a wide repertoire of cellular processes such as proliferation and survival of cells. Along with these ubiquitous cell functions observed in many peripheral tissues sphingolipid metabolites, especially sphingosine 1-phosphate, exert important neuron-specific functions such as regulation of neurotransmitter release. This review summarizes physiological and pathological roles of sphingolipid metabolites emphasizing the role of sphingosine 1-phosphate in the central nervous system.
authors.affiliation: Division of Biochemistry, Department of Biochemistry/Molecular Biology, Kobe University Graduate School of Medicine, Kobe, 650-0017, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Okada
authors.forename: Taketoshi
authors.initials: T
authors.lastname: Kajimoto
authors.forename: Saleem
authors.initials: S
authors.lastname: Jahangeer
authors.forename: Shun-ichi
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D017209:Apoptosis; D002470:Cell Survival / Q000502:physiology; D002490:Central Nervous System / Q000378:metabolism*; D005089:Exocytosis; D008246:Lysophospholipids / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism; D000099157:Sphingosine Kinase
chemical_list: D008246:Lysophospholipids; D018377:Neurotransmitter Agents; D017853:Phosphotransferases (Alcohol Group Acceptor); D013110:Sphingosine; D000099157:Sphingosine Kinase; C060506:sphingosine 1-phosphate