title: Pediatric kidney transplantation: a snapshot 10 years later.
abstract: Herein we report the outcomes of pediatric kidney recipients who underwent transplantation at least 10 years prior. A cohort of 36 patients (mean age, 26.4+/-6 years) with a mean follow-up time of 14.2+/-4 years was selected for the study. Immunosuppression consisted of cyclosporine and steroids. Actuarial patient and graft survivals 15 years after the transplantation were 97% and 86%, respectively. Only 1 patient died due to a complicated sclerosant peritonitis. Graft function was good with a mean serum creatinine of this selected cohort of 1.5+/-0.6 mg/dL. Eighteen percent were class 1, 33% class 2, and 49% chronic kidney disease. Hypertension was treated in almost 80% of the patients. The majority of patients were smaller than the average population with a final height (between 0 and -2) standard deviation score (HSDS) but only 27% had a severe growth impairment (HSDS>-2). Regarding nutritional status, fewer than 30% were overweight and only 1 patient was obese with a body mass index (BMI) >30. The majority of patients, except 2 mentally retarded individuals, are or have been attending normal school and achieved full-time employment. In conclusion, long-term survivors of a kidney transplant received during childhood reached a high degree of rehabilitation despite a long period of immunosuppression.
authors.affiliation: Division of General Surgery and Kidney Tansplant, Mangiagalli and Regina Elena Foundation, IRCCS, Milan, Italy. mariano.ferraresso@unimi.it
authors.forename: M
authors.initials: M
authors.lastname: Ferraresso
authors.forename: L
authors.initials: L
authors.lastname: Ghio
authors.forename: M
authors.initials: M
authors.lastname: Raiteri
authors.forename: M
authors.initials: M
authors.lastname: Belingheri
authors.forename: C
authors.initials: C
authors.lastname: Beretta
authors.forename: V
authors.initials: V
authors.lastname: Martina
authors.forename: A
authors.initials: A
authors.lastname: Edefonti
authors.forename: L
authors.initials: L
authors.lastname: Berardinelli
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D006128:Growth; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D016030:Kidney Transplantation / Q000639:trends*; D016393:Lymphoma, B-Cell / Q000453:epidemiology; D008297:Male; D011183:Postoperative Complications; D012189:Retrospective Studies; D012959:Socioeconomic Factors; D013997:Time Factors