title: D-ribose aids advanced ischemic heart failure patients.
abstract: Patients with advanced heart failure are exercise intolerant. Low cellular energy levels in the failing heart have been proposed. Energy enhancing substrates have revealed mixed results. Ribose, a pentose monosaccharide, has shown to replenish low myocardial energy levels, improving cardiac dysfunction following ischemia, and improving ventilation efficiency in patients with heart failure. As current pharmaceuticals do not address cellular energy levels, this study was designed to investigate the role of ribose on ventilation at anaerobic threshold in congestive heart failure patients. d-ribose (5 gms/dose, tid) was assessed in 16 NYHA class III-IV, heart failure patients with VO(2), tidal volume/VCO(2), heart rate/tidal volume evaluated at 8 weeks. All patients had a significant improvement in ventilatory parameters at anaerobic threshold, along with a 44% Weber class improvement. Ribose improved the ventilatory exercise status in advanced heart failure patients.
authors.forename: Dean
authors.initials: D
authors.lastname: MacCarter
authors.forename: Nampalli
authors.initials: N
authors.lastname: Vijay
authors.forename: Melinda
authors.initials: M
authors.lastname: Washam
authors.forename: Linda
authors.initials: L
authors.lastname: Shecterle
authors.forename: Helen
authors.initials: H
authors.lastname: Sierminski
authors.forename: J A
authors.initials: JA
authors.lastname: St Cyr
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D012266:Ribose / Q000627:therapeutic use*
chemical_list: D012266:Ribose