Concise synthesis of bicyclic aminals and their evaluation as precursors to the sarain core.
A number of bicyclic aminals have been prepared in a stereospecific manner as potential precursors to the core structure of the sarain alkaloids. Rearrangement of these aminals to new diazabicyclic and diazatricyclic systems has been observed under various conditions.
Price Mortimer
Anne J
AJ
Department of Chemistry, University College London, Christopher Ingold Building, 20 Gordon Street, London, UKWC1H 0AJ.
Pang
Pui Shan
PS
Aliev
Abil E
AE
Tocher
Derek A
DA
Porter
Michael J
MJ
D000470:Alkaloids / Q000737:chemistry; D000586:Amination; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D000470:Alkaloids; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; C410431:sarain A