[Association of genetic polymorphism in plasminogen activator inhibitor-1 gene with endometrial hypoplasia in infertile women].
OBJECTIVE
To investigate the relationship between the plasminogen activator inhibitor (PAI-1) polymorphisms and endometrial hypoplasia in infertile women.


METHODS
The study was conducted in 105 primary infertile patients with endometrial hypoplasia diagnosed by pathology and the thickness of endometrium by B-mode ultrasound and 85 controls who were not pregnant and had normal fertility. The -675 4G/5G polymorphism in the PAI-1 gene was detected by polymerase chain reaction-restriction fragment length polymerphim analysis.


RESULTS
The frequencies of 4G/4G genotype and 4G allele of the PAI-1 gene were higher in the patient group (48.6% and 66.2%) than in the normal controls (22.4% and 47.1%) (P < 0.01). ThePAI-1 4G/4G genotype was significantly associated with endometrial hypoplasia in the infertile patients (OR=4.9, 95% CI: 2.10-10.12).


CONCLUSIONS
The present findings suggest that the 4G/5G polymorphism of the PAI-1 gene was associated with endometrial hypoplasia in infertile patients.
Sun
Jing-hua
JH
Department of Genetics,Weifang People's Hospital, Weifang, Shandong, 261041 People's Republic of China. sjhrmyy@sina.com.cn.
Guan
Li -xue
L-
Lin
Dong-ju
DJ
Dai
Pei-feng
PF
Pan
Li
L
Mu
Qian
Q
D000328:Adult; D005260:Female; D006801:Humans; D007246:Infertility / Q000235:genetics*; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D014591:Uterine Diseases / Q000235:genetics*; D016387:Women's Health
D017395:Plasminogen Activator Inhibitor 1