title: Macrolide-resistant Shigella sonnei.
abstract: Shigella sonnei UCN59, isolated during an outbreak of S. sonnei in January 2007, was resistant to azithromycin (MIC 64 mg/L). The isolate contained a plasmid-borne mph(A) gene encoding a macrolide 2 -phosphotransferase that inactivates macrolides. Emergence of the mph(A) gene in S. sonnei may limit usefulness of azithromycin for treatment of shigellosis.
authors.affiliation: Centre Hospitalier Universitaire Côte de Nacre, Caen, France.
authors.forename: Leyla
authors.initials: L
authors.lastname: Boumghar-Bourtchai
authors.forename: Patricia
authors.initials: P
authors.lastname: Mariani-Kurkdjian
authors.forename: Edouard
authors.initials: E
authors.lastname: Bingen
authors.forename: Ingrid
authors.initials: I
authors.lastname: Filliol
authors.forename: Anne
authors.initials: A
authors.lastname: Dhalluin
authors.forename: Shadia Ait
authors.initials: SA
authors.lastname: Ifrane
authors.forename: François-Xavier
authors.initials: FX
authors.lastname: Weill
authors.forename: Roland
authors.initials: R
authors.lastname: Leclercq
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002675:Child, Preschool; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial; D004405:Dysentery, Bacillary / Q000382:microbiology; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012764:Shigella sonnei / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides