title: In vitro antiprotozoal activity of some xanthones isolated from the roots of Andrographis paniculata.
abstract: Four xanthones isolated from the roots of Andrographis paniculata were tested in vitro for antiprotozoal activity against Trypanosoma brucei brucei, Trypanosoma cruzi and Leishmania infantum. Compound TDR13011 (1,2-dihydroxy-6,8-dimethoxy-xanthone) showed good activity against T. b. brucei and L. infantum with a 50% inhibitory concentration (IC50) of 4.6 microg/ml and 8 microg/ml respectively. Xanthones from the roots of Andrographis paniculata exhibited promising anti-protozoal activity and these compounds could be chemically modified to obtain a more potent product.
authors.affiliation: National Institute of Malaria Research, Field Unit, Sector III, BHEL, Hardwar 249 403, India. vkdua51@gmail.com
authors.forename: Virendra K
authors.initials: VK
authors.lastname: Dua
authors.forename: Gaurav
authors.initials: G
authors.lastname: Verma
authors.forename: A P
authors.initials: AP
authors.lastname: Dash
mesh_terms: D035685:Andrographis / Q000737:chemistry*; D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D018314:Leishmania infantum / Q000187:drug effects; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D018517:Plant Roots / Q000737:chemistry; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014349:Trypanosoma cruzi / Q000187:drug effects; D044004:Xanthones / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C534994:2-dihydroxy-6,8-dimethoxy-xanthone; D000981:Antiprotozoal Agents; D044004:Xanthones