title: [Linkage analysis of one family with autosomal dominant high myopia].
abstract: OBJECTIVE
  To map the high myopia gene in a Chinese family with autosomal dominant high myopia.
  
  
  METHODS
  A family with autosomal dominant high myopia in three generations was collected. Eighteen short-tandem-repeat markers on previously reported loci linked to high myopia were chosen for genotyping and two-point linkage analysis was carried out.
  
  
  RESULTS
  The spherical equivalent of affected individuals ranges from -6.00D to -20.00D and the genetic pattern is autosomal dominant. The LOD score was less than -1 in all 18 microsatellite markers, indicating that there was no linkage between these markers and the high myopia related genes in this family.
  
  
  CONCLUSIONS
  A novel myopia locus for high-grade myopia may exist in the kindred. Genome-wide scan will be needed to determine this novel locus.
authors.affiliation: Department of Immunology, West China Medical Center, Sichuan University, Chengdu, Sichuan, 610041 People's Republic of China.
authors.forename: Jin-xia
authors.initials: JX
authors.lastname: Chang
authors.forename: Ding-ding
authors.initials: DD
authors.lastname: Zhang
authors.forename: Yin
authors.initials: Y
authors.lastname: Lin
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Lu
authors.forename: Xin
authors.initials: X
authors.lastname: Tang
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.forename: Chong-jie
authors.initials: CJ
authors.lastname: Zhang
authors.forename: Zheng-lin
authors.initials: ZL
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009216:Myopia / Q000235:genetics*; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D012029:Refraction, Ocular / Q000502:physiology; D055815:Young Adult