title: Intracytoplasmic sperm injection (ICSI) using cryopreserved sperm from men with malignant neoplasm yields high pregnancy rates.
abstract: OBJECTIVE
  To investigate the efficacy of IVF-intracytoplasmic sperm injection (ICSI) in patients who cryobanked semen before cancer treatment.
  
  
  METHODS
  Retrospective consecutive study.
  
  
  METHODS
  University-based IVF unit.
  
  
  METHODS
  One hundred eighteen couples undergoing IVF-ICSI using pretreatment frozen sperm.
  
  
  METHODS
  Treatment follow-up.
  
  
  METHODS
  Semen parameters and clinical pregnancy rates.
  
  
  RESULTS
  One hundred eighteen couples underwent 169 IVF cycles using pretreatment cryopreserved sperm; the average sperm count was 66.5 x 10(6)/mL, and the average motility was 45.6%. Post-thaw sperm average density was 40.9 x 10(6)/mL with 14.2% motility. The clinical pregnancy rate was 56.8% per retrieval; 96 pregnancies were achieved, resulting in 126 children born and 11 spontaneous abortions. Patients with prostate cancer had the worst semen parameters before sperm banking and the lowest clinical pregnancy rates.
  
  
  CONCLUSIONS
  IVF-ICSI is the recommended treatment for most couples with cryopreserved sperm for male cancer. High pregnancy and delivery rates after IVF-ICSI using cryopreserved sperm from patients with cancer should encourage all reproductive-age males to cryobank semen immediately after diagnosis; physicians should discuss this and advise freezing multiple samples before treatment.
authors.affiliation: IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Ariel
authors.initials: A
authors.lastname: Hourvitz
authors.forename: Dan E
authors.initials: DE
authors.lastname: Goldschlag
authors.forename: Owen K
authors.initials: OK
authors.lastname: Davis
authors.forename: Lucinda Veeck
authors.initials: LV
authors.lastname: Gosden
authors.forename: Gianpiero D
authors.initials: GD
authors.lastname: Palermo
authors.forename: Zev
authors.initials: Z
authors.lastname: Rosenwaks
mesh_terms: D000328:Adult; D015897:Comorbidity; D015925:Cryopreservation / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007246:Infertility / Q000453:epidemiology* / Q000628:therapy*; D007557:Israel / Q000453:epidemiology; D008297:Male; D009369:Neoplasms / Q000453:epidemiology*; D011247:Pregnancy; D018873:Pregnancy Rate; D013076:Sperm Count / Q000706:statistics & numerical data*; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data*; D016896:Treatment Outcome