title: Aminoguanidine ameliorates radiation-induced oxidative lung damage in rats.
abstract: OBJECTIVE
  To investigate the possible protective effects of aminoguanidine (AG ) on lung damage in whole body irradiated rats.
  
  
  METHODS
  To evaluate the biological damage of radiation on rat lung tissue, lipid peroxidation products were measured using biochemical parameters. Thirty Wistar albino rats were divided into three subgroups: control (C) , irradiation alone (RT), and RT + AG combined. After sacrificing the rats, antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) activities and malondiadehyde (MDA), nitric oxide (NO) levels were evaluated in lung tissue.
  
  
  RESULTS
  Administration of AG resulted in an increase in the activities of CAT, SOD and GSHPx in the lungs. All were reduced after radiation. In addition, AG administration resulted in a decrease in both NO and MDA levels in lung compared with the irradiated group.
  
  
  CONCLUSIONS
  Amnoguanidine increased the endogenous antioxidant defence mechanism in rats and protected the animals from radiation-induced lung toxicity. Moreover, AG may protect against ionizing radiation-induced lung damage because of its antioxidant effect.
authors.affiliation: Department of Radiation Oncology, Erciyes University, Kayseri, Turkey.
authors.forename: Celalettin
authors.initials: C
authors.lastname: Eroglu
authors.forename: Oguz Galip
authors.initials: OG
authors.lastname: Yildiz
authors.forename: Recep
authors.initials: R
authors.lastname: Saraymen
authors.forename: Serdar
authors.initials: S
authors.lastname: Soyuer
authors.forename: Eser
authors.initials: E
authors.lastname: Kilic
authors.forename: Servet
authors.initials: S
authors.lastname: Ozcan
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects* / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000517:prevention & control*; D011839:Radiation, Ionizing; D051381:Rats; D017208:Rats, Wistar; D012128:Respiratory Distress Syndrome / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism; D014916:Whole-Body Irradiation / Q000009:adverse effects / Q000662:veterinary
chemical_list: D004791:Enzyme Inhibitors; D006146:Guanidines; D009569:Nitric Oxide; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C004479:pimagedine