Effect of intragastric acid stability of fat emulsions on gastric emptying, plasma lipid profile and postprandial satiety.
Fat is often included in common foods as an emulsion of dispersed oil droplets to enhance the organoleptic quality and stability. The intragastric acid stability of emulsified fat may impact on gastric emptying, satiety and plasma lipid absorption. The aim of the present study was to investigate whether, compared with an acid-unstable emulsion, an acid-stable fat emulsion would empty from the stomach more slowly, cause more rapid plasma lipid absorption and cause greater satiety. Eleven healthy male volunteers received on two separate occasions 500 ml of 15 % (w/w) [13C]palmitate-enriched olive oil-in-water emulsion meals which were either stable or unstable in the acid gastric environment. MRI was used to measure gastric emptying and the intragastric oil fraction of the meals. Blood sampling was used to measure plasma lipids and visual analogue scales were used to assess satiety. The acid-unstable fat emulsion broke and rapidly layered in the stomach. Gastric emptying of meal volume was slower for the acid-stable fat emulsion (P < 0.0001; two-way ANOVA). The rate of energy delivery of fat from the stomach to the duodenum was not different up to t = 110 min. The acid-stable emulsion induced increased fullness (P < 0.05), decreased hunger (P < 0.0002), decreased appetite (P < 0.0001) and increased the concentration of palmitic acid tracer in the chylomicron fraction (P < 0.04). This shows that it is possible to delay gastric emptying and increase satiety by stabilising the intragastric distribution of fat emulsions against the gastric acid environment. This could have implications for the design of novel foods.
Marciani
Luca
L
Wolfson Digestive Diseases Centre, Queen's Medical Centre, Nottingham University Hospitals, University of Nottingham, Nottingham NG7 2UH, UK.
Faulks
Richard
R
Wickham
Martin S J
MS
Bush
Debbie
D
Pick
Barbara
B
Wright
Jeff
J
Cox
Eleanor F
EF
Fillery-Travis
Annette
A
Gowland
Penny A
PA
Spiller
Robin C
RC
D000328:Adult; D000704:Analysis of Variance; D002914:Chylomicrons / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D017352:Echo-Planar Imaging; D004655:Emulsions; D005744:Gastric Acid / Q000378:metabolism*; D005746:Gastric Emptying; D005766:Gastrointestinal Contents; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000097:blood*; D008297:Male; D019518:Postprandial Period; D012527:Satiation / Q000502:physiology*; D055815:Young Adult
D002914:Chylomicrons; D004042:Dietary Fats, Unsaturated; D004655:Emulsions; D008055:Lipids