title: A practical and efficient route for the highly enantioselective synthesis of mexiletine analogues and novel beta-thiophenoxy and pyridyl ethers.
abstract: A practical and efficient procedure for the enantioselective synthesis of mexiletine analogues with use of 10% of spiroborate ester 6 as chirality transfer agent is presented. A variety of mexiletine analogues were prepared in good yield with excellent enantioselectivities (91-97% ee) from readily available starting materials. The developed methodology was also successfully applied for the synthesis of novel beta-amino ethers containing thiophenyl and pyridyl fragments.
authors.affiliation: Department of Chemistry, University of Puerto Rico-Humacao, CUH Station, Humacao, Puerto Rico.
authors.forename: Kun
authors.initials: K
authors.lastname: Huang
authors.forename: Margarita
authors.initials: M
authors.lastname: Ortiz-Marciales
authors.forename: Viatcheslav
authors.initials: V
authors.lastname: Stepanenko
authors.forename: Melvin
authors.initials: M
authors.lastname: De Jesús
authors.forename: Wildeliz
authors.initials: W
authors.lastname: Correa
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D001880:Boranes / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D004987:Ethers / Q000138:chemical synthesis*; D008801:Mexiletine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D008956:Models, Chemical; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D000889:Anti-Arrhythmia Agents; D001880:Boranes; D004952:Esters; D004987:Ethers; D011725:Pyridines; D013876:Thiophenes; D008801:Mexiletine