title: Primary malignant peripheral nerve sheath tumor with eosinophilic cytoplasmic globules arising from the greater omentum in a dog.
abstract: A 10-year-old Golden Retriever dog had a solitary tumor mass arising from the greater omentum. Histologically, the tumor showed varying cellularity and patterns of cellular arrangement. In dense cellular areas, spindle-shaped cells were arranged in interlacing bundles. The sparse cellular area was characterized by loosely arranged fusiform cells. The neoplastic cells frequently contained PAS-positive eosinophilic globules in the cytoplasm, and mitotic figures were frequently observed. The tumor cells were positive to vimentin, S-100 protein, glial fibrillary acidic protein, myelin basic protein, neuron-specific enolase and myoglobin. The present tumor was diagnosed as a malignant peripheral nerve sheath tumor (MPNST) with eosinophilic cytoplasmic globules arising from the greater omentum. To our knowledge, this may be the first case of primary omental MPNST in domestic animals.
authors.affiliation: Department of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Minami 4-101, Koyama-cho, Tottori, Japan. sugiyama@muses.tottori-u.ac.jp
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sugiyama
authors.forename: Takehito
authors.initials: T
authors.lastname: Morita
authors.forename: Akinori
authors.initials: A
authors.lastname: Shimada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsuka
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D018317:Nerve Sheath Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D009852:Omentum / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*