Uncapping the potential of renal stem cells.
In this issue of Cell Stem Cell, McMahon and coworkers (Kobayashi et al., 2008) characterize a subset of progenitor cells in the developing kidney. six2-expressing mesenchymal cells exhibit hallmark stem cell traits, in that they appear to self-renew and are clonally multipotent for a range of nephron epithelial cell types.
Quaggin
Susan E
SE
Samuel Lunenfeld Research Institute, 881-600 University Avenue, Toronto, Ontario M5G 1X5, Canada. quaggin@mshri.on.ca
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000166:cytology* / Q000196:embryology / Q000254:growth & development; D007674:Kidney Diseases / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D051379:Mice; D009399:Nephrons / Q000166:cytology* / Q000196:embryology / Q000254:growth & development; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D038081:Organogenesis / Q000502:physiology
D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; C484762:SIX2 protein, human