title: Recombinant activated factor VII in critical bleeding after orthotopic liver transplantation.
abstract: Critical bleeding throughout the intraoperative phase of orthotopic liver transplantation (OLT) strongly increases patient mortality and intensive care unit (ICU) stay. The aim of this study was to report our experience on the use of recombinant activated factor VII (rFVIIa) in postoperative critical bleeding after OLT. In 7 patients with persistent severe bleeding after application of a standard transfusion protocol, we administered a 90 microg/kg bolus of rFVIIa and if necessary eventually repeated it after 3 hours. We recorded the blood loss and the need for transfusions before and after the rFVIIa therapy. Blood losses and need for platelets significantly decreased after rFVIIa administration; a nonsignificant decrease in red blood cells and fresh frozen plasma transfusions also occurred. In 6 patients treatment with rFVIIa was effective; only 1 patient died because of hemorrhagic shock and no thromboses were detected among the treated patients. Awaiting stronger evidence from randomized controlled trials, we suggest that in some challenging cases of massive bleeding rFVIIa should be considered a useful option to control bleeding.
authors.affiliation: Cattedra e Servizio di Anestesia e Rianimazione, Policlinico di Modena, Modena, Italy. stefanobusani@tin.it
authors.forename: S
authors.initials: S
authors.lastname: Busani
authors.forename: G
authors.initials: G
authors.lastname: Semeraro
authors.forename: C
authors.initials: C
authors.lastname: Cantaroni
authors.forename: M
authors.initials: M
authors.lastname: Masetti
authors.forename: M
authors.initials: M
authors.lastname: Marietta
authors.forename: M
authors.initials: M
authors.lastname: Girardis
mesh_terms: D000328:Adult; D000368:Aged; D016063:Blood Loss, Surgical; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy; D019106:Postoperative Hemorrhage / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa