Vaccination of dogs against Echinococcus granulosus: a means to control hydatid disease?
Hydatid disease continues to be a substantial cause of morbidity and mortality worldwide. Elimination is difficult with current control options, but reducing egg production by Echinococcus granulosus (Eg) in canines might help to reduce transmission in areas where the parasite is endemic. Recently obtained data using recombinant protein-based and live attenuated Salmonella vaccines are preliminary but encouraging and auger well for the future development of an effective dog vaccine against Eg, although much additional work is required before this becomes a reality. New approaches to control and for the prevention of hydatidosis have been described recently, and important additional gains should be expected if the efficacy of the dog vaccines is confirmed and leads to their incorporation into future control options.
Zhang
Wenbao
W
Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, QLD 4006, Australia.
McManus
Donald P
DP
D000818:Animals; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D004443:Echinococcosis / Q000517:prevention & control / Q000662:veterinary*; D048209:Echinococcus granulosus / Q000276:immunology*; D006801:Humans; D015800:Protozoan Proteins / Q000276:immunology; D016052:Protozoan Vaccines / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology; D012475:Salmonella; D014613:Vaccines, Attenuated / Q000276:immunology
D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D011994:Recombinant Proteins; D014613:Vaccines, Attenuated