Preparation and in vitro evaluation of controlled release hydrophilic matrix tablets of ketorolac tromethamine using factorial design.
Controlled release matrix tablets of ketorolac tromethamine (KT) were prepared by direct compression technique using cellulose derivatives as hydroxypropylmethyl cellulose (HPMC), hydroxyethyl cellulose (HEC), and carboxymethyl cellulose (CMC) in different concentrations (10-20%). The effect of polymer type and concentration was investigated on drug release by 2(3) factorial design. For the quality control of matrix tablets, weight deviation, hardness, friability, diameter-height ratio, content uniformity of KT, and in vitro dissolution technique were performed. UV Spectrophotometric method was used to detection of KT in matrix tablets. This method was validated. Dissolution profiles of the formulations were plotted and evaluated kinetically. An increase in polymer content resulted with a slow release rate of drug as was expected. According to the dissolution results, tablets prepared with HPMC + HEC + CMC (F1 and F8) were found to be the most suitable formulation for KT. About 99.27% KT was released from F8 in 7 h.
Genç
Lütfi
L
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eskisehir, Turkey. lgenc@anadolu.edu.tr
Jalvand
Esmaeil
E
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D065347:Hypromellose Derivatives; D020911:Ketorolac Tromethamine / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D013607:Tablets
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D013607:Tablets; D065347:Hypromellose Derivatives; D020911:Ketorolac Tromethamine; D002482:Cellulose; D008747:Methylcellulose; D002266:Carboxymethylcellulose Sodium