Hypothalamic-pituitary-adrenal system and enzymes of the glutathione-dependent antioxidant system during stress and aging.
Activity of glutathione-dependent antioxidant enzymes (glutathione peroxidase, glutathione reductase, and glutathione transferase) in blood erythrocytes from female Macaca mulatta (6-8 and 20-26 years) was measured during activation of the hypothalamic-pituitary-adrenal system under conditions of acute psychoemotional stress (2-h restraint stress). Glutathione reductase activity increased during stress, depended on the time of day, and strongly correlated with blood corticosteroid level. Circadian variations in stress reactivity of glutathione reductase during aging were accompanied by similar changes in stress reactivity of the hypothalamic-pituitary-adrenal system.
Goncharova
N D
ND
Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi. ndgoncharova@mail.ru
Shmaliy
A V
AV
Marenin
V Yu
VY
Smelkova
S A
SA
D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002940:Circadian Rhythm; D005260:Female; D005978:Glutathione / Q000097:blood / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D000882:Haplorhini; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D012149:Restraint, Physical / Q000009:adverse effects; D013312:Stress, Physiological / Q000209:etiology / Q000503:physiopathology*
D000975:Antioxidants; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione; D006854:Hydrocortisone