Total synthesis of the originally proposed and revised structures of scleritodermin A.
The first total synthesis of the originally proposed and revised structure of scleritodermin A, along with an isomer, were achieved by the use of an alpha-azido carboxyl group serving as the key alpha-ketoamide precursor, thus leading to a revision of the structure originally proposed for natural scleritodermin A.
Liu
Sheng
S
Chinese National Center for Drug Screening, State Key Laboratory of Drug Research Shanghai Institute of Materia Medica, Chinese Academy of Sciences 189 Guoshoujing Road, Zhangjiang Hi-Tech Park, Shanghai 201203,China.
Cui
Yong-Mei
YM
Nan
Fa-Jun
FJ
D000577:Amides / Q000737:chemistry; D007536:Isomerism; D007659:Ketones / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
D000577:Amides; D007659:Ketones; D010456:Peptides, Cyclic; C484931:scleritodermin A