The role of bone in osteoarthritis pathogenesis.
This article focuses on the specific skeletal features of osteoarthritis and the putative mechanisms involved in their pathogenesis. In addition, the relationship of these changes to the alterations in articular cartilage and the other tissues comprising the diarthrodial joint are reviewed.
Goldring
Steven R
SR
The Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA. goldrings@hss.edu
D000818:Animals; D015519:Bone Density; D016723:Bone Remodeling / Q000502:physiology; D001862:Bone Resorption; D001842:Bone and Bones / Q000473:pathology* / Q000503:physiopathology; D002358:Cartilage, Articular / Q000473:pathology* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D010003:Osteoarthritis / Q000473:pathology* / Q000503:physiopathology; D015207:Osteoarthritis, Hip / Q000473:pathology / Q000503:physiopathology; D020370:Osteoarthritis, Knee / Q000473:pathology / Q000503:physiopathology; D011379:Prognosis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013583:Synovial Membrane / Q000473:pathology* / Q000503:physiopathology