title: A history of preeclampsia identifies women who have underlying cardiovascular risk factors.
abstract: OBJECTIVE
  The objective of this study was to prospectively assess physical and biochemical cardiovascular risk markers in women who had developed preeclampsia (PE) at 1 year postpartum.
  
  
  METHODS
  Following an overnight fast, previously PE (n = 70) and normotensive women (n = 70) had weight and blood pressure recorded and levels of morning blood for insulin, glucose, C-reactive protein, lipids, cholesterol, and urine for microalbumin and creatinine measured. Body mass index, homeostatic model assessment index, and incidence of metabolic syndrome were determined.
  
  
  RESULTS
  At 1 year postpartum, markers of cardiovascular disease were different between the groups. There were also differences in the number of women with abnormal values. Mathematical modeling of cardiovascular event risk suggests that PE increases the risk by 2- to 3-fold; the risk was greatest for women with severe PE.
  
  
  CONCLUSIONS
  The development of PE is 1 of the earliest clinically identifiable markers of a woman's heightened risk of cardiovascular disease.
authors.affiliation: Queen's Perinatal Research Unit, Department of Obstetrics and Gynecology, Kingston General Hospital, Queen's University, Kingston, Canada. gns@queensu.ca
authors.forename: Graeme N
authors.initials: GN
authors.lastname: Smith
authors.forename: Mark C
authors.initials: MC
authors.lastname: Walker
authors.forename: Aizhong
authors.initials: A
authors.lastname: Liu
authors.forename: Shi Wu
authors.initials: SW
authors.lastname: Wen
authors.forename: Melissa
authors.initials: M
authors.lastname: Swansburg
authors.forename: Heather
authors.initials: H
authors.lastname: Ramshaw
authors.forename: Ruth Rennicks
authors.initials: RR
authors.lastname: White
authors.forename: Michelle
authors.initials: M
authors.lastname: Roddy
authors.forename: Michelle
authors.initials: M
authors.lastname: Hladunewich
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000097:blood / Q000652:urine; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000000981:diagnostic imaging; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008137:Longitudinal Studies; D024821:Metabolic Syndrome / Q000097:blood / Q000000981:diagnostic imaging; D015233:Models, Statistical; D011225:Pre-Eclampsia / Q000097:blood* / Q000000981:diagnostic imaging; D011247:Pregnancy; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood; D014463:Ultrasonography
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol; D003404:Creatinine