Synthesis of Prolinal Dithioacetals as Catalysts for the Highly Stereoselective Michael Addition of Ketones and Aldehydes to beta-Nitrostyrenes.
Catalytic highly enantioselective (up to >99% ee) and diastereoselective (up to 99% de) direct Michael addition of ketones and aldehydes to beta-nitrostyrenes have been achieved with readily accessible and highly tunable prolinal dithioacetal catalysts.
Mandal
Tanmay
T
Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX78249, USA.
Zhao
Cong-Gui
CG