title: Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection.
abstract: 2-(2-Methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, a novel anilidoquinoline derivative, was synthesised and evaluated for its therapeutic efficacy in treating Japanese encephalitis. The compound showed significant antiviral and antiapoptotic effects in vitro. Significant decreases in viral load (P<0.01) combined with an increase in survival was observed in Japanese encephalitis virus-infected mice treated with 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide.
authors.affiliation: National Brain Research Centre, Manesar, Haryana, India.
authors.forename: Joydeep
authors.initials: J
authors.lastname: Ghosh
authors.forename: Vivek
authors.initials: V
authors.lastname: Swarup
authors.forename: Amit
authors.initials: A
authors.lastname: Saxena
authors.forename: Sulagna
authors.initials: S
authors.lastname: Das
authors.forename: Abhijit
authors.initials: A
authors.lastname: Hazra
authors.forename: Priyankar
authors.initials: P
authors.lastname: Paira
authors.forename: Sukdeb
authors.initials: S
authors.lastname: Banerjee
authors.forename: Nirup B
authors.initials: NB
authors.lastname: Mondal
authors.forename: Anirban
authors.initials: A
authors.lastname: Basu
mesh_terms: D000081:Acetamides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D000083:Acetanilides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000634:Aminoquinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D004664:Encephalitis Virus, Japanese / Q000187:drug effects / Q000472:pathogenicity*; D004672:Encephalitis, Japanese / Q000188:drug therapy* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: C533850:2-(2-methylquinolin-4-ylamino)-N-(2-chlorophenyl)acetamide; D000081:Acetamides; D000083:Acetanilides; D000634:Aminoquinolines; D000998:Antiviral Agents; D018696:Neuroprotective Agents; D011804:Quinolines; C030686:acetamide; C037219:quinoline