Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia.
Schizophrenia is a common psychiatric disorder with a strong genetic contribution. Disease-associated chromosomal abnormalities in this condition may provide important clues, such as DISC1. In this study, 59 schizophrenia patients were analyzed by microarray comparative genomic hybridization (CGH) using custom bacterial artificial chromosome (BAC) microarray (4,219 BACs with 0.7-Mb resolution). Chromosomal abnormalities were found in six patients (10%): 46,XY,der(13)t(12;13)(p12.1; p11).ish del(5)(p11p12); 46,XY, ish del(17)(p12p12); 46,XX.ish dup(11)(p13p13); and 46,X,idic(Y)(q11.2); and in two cases, mos 45,X/46XX. Autosomal abnormalities in three cases are likely to be pathogenic, and sex chromosome abnormalities in three follow previous findings. It is noteworthy that 10% of patients with schizophrenia have (sub)microscopic chromosomal abnormalities, indicating that genome-wide copy number survey should be considered in genetic studies of schizophrenia.
Mizuguchi
Takeshi
T
Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan.
Hashimoto
Ryota
R
Department of Mental Disorder Research, National Center of Neurology and Psychiatry, Kodaira, Japan.|Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan.
Itokawa
Masanari
M
Schizophrenia Research Team, Schizophrenia Project, Tokyo Institute of Psychiatry, Tokyo, Japan.
Sano
Akira
A
Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Shimokawa
Osamu
O
Department of Molecular Cytogenetics, Kyushu Medical Science, Inc., Nagasaki, Japan.
Yoshimura
Yukiko
Y
Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan.
Harada
Naoki
N
Department of Molecular Cytogenetics, Kyushu Medical Science, Inc., Nagasaki, Japan.
Miyake
Noriko
N
Department of Medicine (Genetics), Children's Hospital Boston, Boston, MA, USA.|Department of Neurology, Harvard Medical School, Boston, MA, USA.
Nishimura
Akira
A
Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan.
Saitsu
Hirotomo
H
Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan.
Sosonkina
Nadiya
N
The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido, Tobetsu-cho, Ishikari-gun, Japan.
Niikawa
Norio
N
The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido, Tobetsu-cho, Ishikari-gun, Japan.
Kunugi
Hiroshi
H
Department of Mental Disorder Research, National Center of Neurology and Psychiatry, Kodaira, Japan.
Matsumoto
Naomichi
N
Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, 236-0004, Japan. naomat@yokohama-cu.ac.jp.
D002869:Chromosome Aberrations; D022202:Chromosomes, Artificial, Bacterial; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D009693:Nucleic Acid Hybridization / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012559:Schizophrenia / Q000235:genetics*