Transplantation of olfactory mucosa following spinal cord injury promotes recovery in rats.
Several recent studies have demonstrated the potential therapeutic role of olfactory ensheathing cells in spinal cord injury. The aim of this study was to elucidate whether grafts of nasal olfactory mucosa containing olfactory ensheathing cells can repair the injured rat spinal cord as compared with the nasal respiratory mucosa containing no olfactory ensheathing cells. These grafts were then transplanted into the partially removed rat spinal cord. Compared with the respiratory mucosa-transplanted rats, the olfactory mucosa-transplanted rats partially recovered the movement of their hindlimbs and joints. Corticospinal tracing indicated that olfactory mucosa transplantation restored the severed tract. Therefore, olfactory mucosa has potential value in the repair of spinal cord injury.
Iwatsuki
Koichi
K
aDepartment of Neurosurgery, Osaka University Medical School, Suita, Osaka, Japan.
Yoshimine
Toshiki
T
Kishima
Haruhiko
H
Aoki
Masanori
M
Yoshimura
Kazuhiro
K
Ishihara
Masahiro
M
Ohnishi
Yuichiro
Y
Lima
Carlos
C
D000818:Animals; D005260:Female; D006614:Hindlimb / Q000294:innervation / Q000502:physiology; D009043:Motor Activity / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology; D009831:Olfactory Mucosa / Q000637:transplantation*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000502:physiology*; D020545:Respiratory Mucosa / Q000637:transplantation*; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000601:surgery*; D016378:Tissue Transplantation / Q000379:methods; D014182:Transplantation, Autologous; D016896:Treatment Outcome