Physiochemical drug properties associated with in vivo toxicological outcomes.
Relationships between physicochemical drug properties and toxicity were inferred from a data set consisting of animal in vivo toleration (IVT) studies on 245 preclinical Pfizer compounds; an increased likelihood of toxic events was found for less polar, more lipophilic compounds. This trend held across a wide range of types of toxicity and across a broad swath of chemical space.
Hughes
Jason D
JD
Pfizer Research Technology Center, Cambridge, MA 02139, USA.
Blagg
Julian
J
Price
David A
DA
Bailey
Simon
S
Decrescenzo
Gary A
GA
Devraj
Rajesh V
RV
Ellsworth
Edmund
E
Fobian
Yvette M
YM
Gibbs
Michael E
ME
Gilles
Richard W
RW
Greene
Nigel
N
Huang
Enoch
E
Krieger-Burke
Teresa
T
Loesel
Jens
J
Wager
Travis
T
Whiteley
Larry
L
Zhang
Yao
Y
D000818:Animals; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D051381:Rats; D013329:Structure-Activity Relationship
D004364:Pharmaceutical Preparations