title: Regression of hepatic fibrosis after intestinal transplantation in total parenteral nutrition liver disease.
abstract: OBJECTIVE
  Hepatic fibrosis may occur in patients with intestinal failure requiring total parenteral nutrition, leading to liver dysfunction necessitating combined intestinal and liver transplantation. The decision to perform combined transplantation as opposed to an isolated intestinal transplant is based on the presence of hyperbilirubinemia, portal hypertension, and advanced hepatic fibrosis.
  
  
  METHODS
  We identified 4 patients who underwent isolated intestinal transplantation having significant liver fibrosis. A novel image analysis technique was applied to serial liver biopsies to more precisely quantitate posttransplantation fibrosis regression separately within both portal and centrilobular areas.
  
  
  RESULTS
  All patients were found to have significant portal and centrilobular fibrosis regression, which occurred more rapidly in the former. Two patients had improvement in fibrosis despite infections and continuation of total parenteral nutrition, suggesting that hepatic fibrosis associated with intestinal failure may in part be related to adequate anatomic and functional bowel length.
  
  
  CONCLUSIONS
  Significant hepatic fibrosis and liver dysfunction may regress after intestinal transplantation and fibrosis regresses more rapidly in portal areas. This suggests that some patients with intestinal failure and associated liver disease may safely undergo isolated intestinal transplant without the need for concurrent liver transplantation and its attendant higher morbidity and mortality.
authors.affiliation: The Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA. mariaisabel.fiel@mountsinai.org
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Fiel
authors.forename: Bernhard
authors.initials: B
authors.lastname: Sauter
authors.forename: Hai-Shan
authors.initials: HS
authors.lastname: Wu
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Rodriguez-Laiz
authors.forename: Gabriel
authors.initials: G
authors.lastname: Gondolesi
authors.forename: Kishore
authors.initials: K
authors.lastname: Iyer
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Schiano
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007410:Intestinal Diseases / Q000628:therapy*; D008103:Liver Cirrhosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D012720:Severity of Illness Index