title: Rapid multistep synthesis of 1,2,4-oxadiazoles in a single continuous microreactor sequence.
abstract: A general method for the synthesis of bis-substituted 1,2,4-oxadiazoles from readily available arylnitriles and activated carbonyls in a single continuous microreactor sequence is described. The synthesis incorporates three sequential microreactors to produce 1,2,4-oxadiazoles in approximately 30 min in quantities (40-80 mg) sufficient for full characterization and rapid library supply.
authors.affiliation: The San Diego Center for Chemical Genomics, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, Califoria 92037, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Grant
authors.forename: Russell
authors.initials: R
authors.lastname: Dahl
authors.forename: Nicholas D P
authors.initials: ND
authors.lastname: Cosford
mesh_terms: D003500:Cyclization; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods*; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries; D013237:Stereoisomerism
chemical_list: D010069:Oxadiazoles; D054852:Small Molecule Libraries