title: Repressed ileal artery aneurysms in Churg-Strauss syndrome following combination treatment with glucocorticoid and cyclophosphamide.
abstract: Churg-Strauss syndrome (CSS) is a systemic small-vessel vasculitis characterized by asthma and eosinophilia. We report a case of CSS complicated by multiple aneurysms in the small intestine. A 57-year-old man was admitted to our hospital with fever and blood eosinophilila. During admission, aneurysms in his small intestine ruptured and partial resection of the small intestine was required. After combination therapy of glucocorticoid (GC) and cyclophosphamide (CYC) for 6 months, aneurysms in the small intestine disappeared. The gastrointestinal involvements usually result in poor prognosis in CSS. However, combination therapy of GC and CYC might be effective for remission of aneurysms caused by small vessel vasculitis.
authors.affiliation: Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, 36-1 Nishi-machi, Yonago, Tottori, 683-8504, Japan. yamasaki@grape.med.tottori-u.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Yamasaki
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Tomita
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Fujii
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Masanari
authors.initials: M
authors.lastname: Watanabe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sano
authors.forename: Ryota
authors.initials: R
authors.lastname: Okazaki
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Ouchi
authors.forename: Seiichi
authors.initials: S
authors.lastname: Nakamura
authors.forename: Eiji
authors.initials: E
authors.lastname: Shimizu
mesh_terms: D000783:Aneurysm / Q000188:drug therapy* / Q000209:etiology; D015267:Churg-Strauss Syndrome / Q000150:complications / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007082:Ileum / Q000098:blood supply; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008638:Mesenteric Arteries / Q000473:pathology; D008875:Middle Aged
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide