title: Cannabis use in Spanish patients with multiple sclerosis: fulfilment of patients' expectations?
abstract: OBJECTIVE
  Medicinal use of cannabis in chronic neurological diseases is a controversial topic of medical research and the subject of intense public debate. The aim of the study was to evaluate the prevalence of cannabis use, related factors, and degree of satisfaction in Spanish patients with multiple sclerosis (MS) prior to the establishment of medically supervised use.
  
  
  METHODS
  Cross-sectional, questionnaire-based survey provided during routine medical visits to consecutive patients in two university-based neurology clinics.
  
  
  RESULTS
  The questionnaire was returned by 175 MS patients (94.1% response rate). The prevalence of ever-use and medicinal cannabis use were 43% and 17.1%, respectively. At the time of the survey, cannabis was being used by 12.5% (5/45) of recreational and 56.7% (17/30) of medical users (p<0.001). First cannabis consumption was after MS onset in 15 (50%) medicinal users. Clinical improvement was reported by 14 (46.7%) medicinal users. Smoking use, awareness of cannabis potential benefits, pain, higher disability, and lower age were independently associated with the medicinal use of cannabis. Most patients would support a future legalisation of cannabis for the control of their symptoms and were willing to receive cannabis under medical control once legalised (83.4% of never-users, 94.5% of ever-users, p<0.05).
  
  
  CONCLUSIONS
  Almost half of our MS patients had tried cannabis at some time. However, medicinal use was low and clinical improvement after cannabis use was only reported by a subset of patients. Overall, MS patients were highly motivated for a future medically controlled use.
authors.affiliation: Neurology Service, Hospital del Mar, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain. 33029jmr@comb.es
authors.forename: Jose E
authors.initials: JE
authors.lastname: Martínez-Rodríguez
authors.forename: Elvira
authors.initials: E
authors.lastname: Munteis
authors.forename: Mar
authors.initials: M
authors.lastname: Carreño
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Blanco
authors.forename: Jaume
authors.initials: J
authors.lastname: Roquer
authors.forename: Sergio
authors.initials: S
authors.lastname: Abanades
authors.forename: Francesc
authors.initials: F
authors.lastname: Graus
authors.forename: Albert
authors.initials: A
authors.lastname: Saiz
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008385:Marijuana Smoking / Q000453:epidemiology* / Q000523:psychology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000523:psychology*; D015999:Multivariate Analysis; D016017:Odds Ratio; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology