title: Mother-to-daughter occurrence of biliary atresia: a case report.
abstract: We herein report a case of mother-to-daughter occurrence of biliary atresia (BA). The mother underwent a Kasai hepatic portoenterostomy at the age of 64 days with a diagnosis of type III BA. Her postoperative course was uneventful, with a good bile discharge, and she became pregnant at the age of 20 years. At 21 weeks of gestational age, fetal ultrasonographic examination of the baby revealed a cystic mass at the hepatic hilum. The baby was born via vaginal delivery at 41 weeks of gestation with a birth weight of 3269 g. Because of an increasing direct bilirubin level and the absence of bile excretion, a laparotomy was performed at the age of 29 days. Intraoperative cholangiography revealed the diagnosis of BA I-cyst, and a hepaticojejunostomy was performed with a good bile discharge. To our knowledge, these patients are the first occurrence of BA in a transmission pattern of mother to daughter.
authors.affiliation: Department of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences 1-757, Asahimachi-Dori, Niigata 951-8510, Japan. kumikumi@xa3.so-net.ne.jp
authors.forename: Kumiko
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kubota
authors.forename: Naoki
authors.initials: N
authors.lastname: Okuyama
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hirayama
authors.forename: Mami
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kanako
authors.initials: K
authors.lastname: Sato
mesh_terms: D000714:Anastomosis, Surgical; D001656:Biliary Atresia / Q000000981:diagnostic imaging / Q000235:genetics* / Q000601:surgery*; D001662:Biliary Tract Surgical Procedures / Q000379:methods*; D002758:Cholangiography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D009035:Mothers; D009679:Nuclear Family; D010375:Pedigree; D035583:Rare Diseases; D018570:Risk Assessment; D014463:Ultrasonography