title: Biodegradable and radically polymerized elastomers with enhanced processing capabilities.
abstract: The development of biodegradable materials with elastomeric properties is beneficial for a variety of applications, including for use in the engineering of soft tissues. Although others have developed biodegradable elastomers, they are restricted by their processing at high temperatures and under vacuum, which limits their fabrication into complex scaffolds. To overcome this, we have modified precursors to a tough biodegradable elastomer, poly(glycerol sebacate) (PGS) with acrylates to impart control over the crosslinking process and allow for more processing options. The acrylated-PGS (Acr-PGS) macromers are capable of crosslinking through free radical initiation mechanisms (e.g., redox and photo-initiated polymerizations). Alterations in the molecular weight and % acrylation of the Acr-PGS led to changes in formed network mechanical properties. In general, Young's modulus increased with % acrylation and the % strain at break increased with molecular weight when the % acrylation was held constant. Based on the mechanical properties, one macromer was further investigated for in vitro and in vivo degradation and biocompatibility. A mild to moderate inflammatory response typical of implantable biodegradable polymers was observed, even when formed as an injectable system with redox initiation. Moreover, fibrous scaffolds of Acr-PGS and a carrier polymer, poly(ethylene oxide), were prepared via an electrospinning and photopolymerization technique and the fiber morphology was dependent on the ratio of these components. This system provides biodegradable polymers with tunable properties and enhanced processing capabilities towards the advancement of approaches in engineering soft tissues.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Jamie L
authors.initials: JL
authors.lastname: Ifkovits
authors.forename: Robert F
authors.initials: RF
authors.lastname: Padera
authors.forename: Jason A
authors.initials: JA
authors.lastname: Burdick
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D003651:Decanoates / Q000737:chemistry* / Q000494:pharmacology*; D004548:Elasticity; D020724:Elastomers / Q000737:chemistry / Q000494:pharmacology; D005990:Glycerol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008422:Materials Testing; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000166:cytology* / Q000187:drug effects*; D013314:Stress, Mechanical
chemical_list: D001672:Biocompatible Materials; D003651:Decanoates; D020724:Elastomers; D011108:Polymers; C469892:poly(glycerol-sebacate); D005990:Glycerol