The HPA axis in major depression: classical theories and new developments.
Studies over the last 40 years have demonstrated that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.
Pariante
Carmine M
CM
Institute of Psychiatry, King's College London, Division of Psychological Medicine and Psychiatry, Centre for the Cellular Basis of Behaviour, London, UK.
Lightman
Stafford L
SL
D003865:Major Depressive Disorder / Q000503:physiopathology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011965:Receptors, Glucocorticoid / Q000502:physiology*
D011965:Receptors, Glucocorticoid