title: Optimization studies on floating multiparticulate gastroretentive drug delivery system of famotidine.
abstract: The objective of this study was to optimize floating microballoons of famotidine by the emulsion solvent diffusion technique using central composite design. Formulations F1-F15 were prepared using three independent variables (pH of medium, drug: Eudragit S100 ratio and ethanol : dichloromethane ratio) and evaluated for dependent variables (shape, percentage buoyancy, and encapsulation). The optimized formulation F9 was fractionated and a polymer combination of (Eudragit S100 : Eudragit L100-55, 9.5:0.5) resulted in microballoons that exhibited zero order release (94.73%) with 84.20% buoyancy at the end of the eighth hour when studied in the mesh-designed modified USP type II apparatus.
authors.affiliation: Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, India.
authors.forename: Reshu
authors.initials: R
authors.lastname: Gupta
authors.forename: Kamla
authors.initials: K
authors.lastname: Pathak
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods* / Q000592:standards; D015738:Famotidine / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D005765:Gastrointestinal Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008863:Microspheres; D010316:Particle Size
chemical_list: D004337:Drug Carriers; D005765:Gastrointestinal Agents; D015738:Famotidine