title: [A case of left urothelial carcinoma with multiple bone metastasis, liver metastasis and right adrenal metastasis successfully treated with combination chemotherapy of gemcitabine and carboplatin].
abstract: The patient was a 53-year-old male. He had been admitted to another hospital with a complaint of left sciatica. He was referred to our hospital for further examination and therapy. He was diagnosed as left urothelial carcinoma with multiple bone metastasis, liver metastasis and right adrenal metastasis. He was treated with combination chemotherapy of gemcitabine and carboplatin (1,000 mg/m2 day 1 and AUC 2 day 1, respectively) biweekly. After the ninth course, a significant tumor reduction was obtained, and has been maintained. He has been treated on an outpatient basis because of no grade 3 or severer adverse reactions. We report an effective case of biweekly chemotherapy with gemcitabine and carboplatin in the treatment of advanced urothelial carcinoma.
authors.affiliation: Dept. of Pharmacy, Houju Memorial Hospital.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Kiba
authors.forename: Mitsue
authors.initials: M
authors.lastname: Mori
authors.forename: Kengou
authors.initials: K
authors.lastname: Hokkoku
authors.forename: Yuri
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Mika
authors.initials: M
authors.lastname: Oikawa
authors.forename: Kimiko
authors.initials: K
authors.lastname: Shintaku
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Mizuno
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshimitsu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakuma
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueda
authors.forename: Masuo
authors.initials: M
authors.lastname: Nakai
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D016190:Carboplatin / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014523:Urethral Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D016190:Carboplatin; D000093542:Gemcitabine