title: B-type natriuretic peptide is related to histological skeletal muscle abnormalities in patients with chronic heart failure.
abstract: This study examined the potential association between skeletal muscle histological findings and circulating levels of N-terminal Atrial natriuretic peptide (NT-proANP) and N-terminal B-type natriuretic peptide (NT-proBNP) at rest and during exercise in patients with moderate chronic heart failure. We report a significant correlation between muscle fibre roundness, defined as ratio of fibre perimeter squared to fibre area, and plasma levels of N-BNP. This finding suggests that the degree of intrafibrillar edema is related to the secretion of NT-proBNP.
authors.affiliation: Department of Cardiology, Stavanger University Hospital, Norway. laai@sus.no
authors.forename: Alf Inge
authors.initials: AI
authors.lastname: Larsen
authors.forename: Øyvind
authors.initials: Ø
authors.lastname: Skadberg
authors.forename: Torbjørn
authors.initials: T
authors.lastname: Aarsland
authors.forename: Jan Terje
authors.initials: JT
authors.lastname: Kvaløy
authors.forename: Sigurd
authors.initials: S
authors.lastname: Lindal
authors.forename: Torbjørn
authors.initials: T
authors.lastname: Omland
authors.forename: Kenneth
authors.initials: K
authors.lastname: Dickstein
mesh_terms: D000368:Aged; D002908:Chronic Disease; D006333:Heart Failure / Q000097:blood* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000473:pathology*; D020097:Natriuretic Peptide, Brain / Q000097:blood*
chemical_list: D020097:Natriuretic Peptide, Brain