Structural mechanism of RNA recognition by the RIG-I-like receptors.
Cytoplasmic nonself RNA, such as that generated by invading viruses, is recognized by a family of sensory molecules termed RIG-I-like Receptors (RLRs). Here, we discuss the mechanism of the RLRs' sensing of nonself RNA. Our findings define three functional domains of RLRs and provide insights into how RLRs function as a molecular switch through interactions with virus-specific RNA ligands.
Yoneyama
Mitsutoshi
M
Laboratory of Molecular Genetics, Institute for Virus Research, and Laboratory of Molecular Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto, 606-8507, Japan.
Fujita
Takashi
T
D000818:Animals; D053468:CARD Signaling Adaptor Proteins / Q000276:immunology / Q000378:metabolism*; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D008024:Ligands; D051379:Mice; D017434:Protein Structure, Tertiary; D012330:RNA, Double-Stranded / Q000276:immunology / Q000378:metabolism*; D012367:RNA, Viral / Q000276:immunology / Q000378:metabolism*
D053468:CARD Signaling Adaptor Proteins; D008024:Ligands; D012330:RNA, Double-Stranded; D012367:RNA, Viral; C503356:Ddx58 protein, mouse; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases