title: [A case of long survival with unresectable duodenal papilla cancer treated with oral chemotherapy using combination UFT and cyclophosphamide].
abstract: A 69-year-old female patient underwent a choledochojejunostomy for unresectable duodenal papilla cancer with para-aortic lymph node metastases. Both tegafur-uracil(UFT) and cyclophosphamide were given orally every day after surgery. Twenty-eight months from the initiation of the chemotherapy the tumor had remarkably reduced and the objective response was evaluated as a PR. The patient is now doing well. Lymph node metastasis is considered an important prognostic factor of papilla Vater carcinoma, and especially with para-aortic lymph node metastases the long-term prognosis is poor. Combination chemotherapy using UFT and cyclophosphamide would be a therapeutic option for elderly or high-risk patients.
authors.affiliation: Dept. of Surgery, Kitakyushu Municipal Medical Center.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Mikami
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Nishihara
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Matsunaga
authors.forename: Yuji
authors.initials: Y
authors.lastname: Abe
authors.forename: Shoshu
authors.initials: S
authors.lastname: Mitsuyama
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Nasu
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yamamoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Toyoshima
authors.forename: Makoto
authors.initials: M
authors.lastname: Motooka
mesh_terms: D000236:Adenoma / Q000188:drug therapy* / Q000473:pathology; D000284:Administration, Oral; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D004379:Duodenal Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D004384:Duodenoscopy; D005260:Female; D006801:Humans; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014498:Uracil / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014408:Biomarkers, Tumor; D005641:Tegafur; D014498:Uracil; D003520:Cyclophosphamide