title: Diet and aging.
abstract: Interventions that extend life span by moderately reduced nutrient intake are often referred to as dietary or calorie restriction. Its efficacy in many species has led to the conclusion that a single, evolutionarily conserved, molecular mechanism operates in all cases to extend life. Here we discuss examples of diet/genotype interactions that show a more complex mechanistic view is required and that mild dietary modifications can dramatically change the interpretation of model organism aging studies.
authors.affiliation: UCL Institute of Healthy Ageing, University College London, London, WC1E 6BT, UK. m.piper@ucl.ac.uk
authors.forename: Matthew D W
authors.initials: MD
authors.lastname: Piper
authors.forename: Andrzej
authors.initials: A
authors.lastname: Bartke
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism; D031204:Caloric Restriction / Q000379:methods*; D004330:Drosophila / Q000378:metabolism; D002149:Energy Intake / Q000502:physiology*; D005508:Food Deprivation / Q000502:physiology*; D005526:Food, Formulated / Q000592:standards; D006801:Humans; D008136:Longevity / Q000235:genetics*; D023421:Models, Animal; D009154:Mutation / Q000235:genetics