title: Interval double transfer improves treatment success in patients with repeated IVF/ET failures.
abstract: OBJECTIVE
  To examine whether double transfer of embryos on day 2-3 and on day 5 after ovum pick-up (OPU) improves IVF/ET success rates in patients with multiple consecutive IVF failures
  
  
  METHODS
  Consecutive IVF failures patients (7.6 +/- 0.5) undergoing IVF/ET cycles were treated with interval double transfer on day 2-3 and on day 5 after OPU. Matched patients, that had embryos transferred only once on day 2 or 3 served as controls.
  
  
  RESULTS
  Baseline and cycle characteristics were similar in the study group and controls. The total pregnancy rate was 44.6% in the study group and 24.2% in the controls (p = 0.001), and the clinical pregnancy rates were 38.5% and 19.6%, respectively (p = 0.001).
  
  
  CONCLUSIONS
  Patients with multiple consecutive IVF/ET failures, treated with the interval double transfer approach had significantly improved cycle success rates compared with regular day 2 or 3 embryo transfer protocol.
authors.affiliation: Sarah Racine IVF Unit, Lis Maternity Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel. bennyalm@post.tau.ac.il
authors.forename: B
authors.initials: B
authors.lastname: Almog
authors.forename: I
authors.initials: I
authors.lastname: Levin
authors.forename: I
authors.initials: I
authors.lastname: Wagman
authors.forename: R
authors.initials: R
authors.lastname: Kapustiansky
authors.forename: T
authors.initials: T
authors.lastname: Schwartz
authors.forename: N
authors.initials: N
authors.lastname: Mey-Raz
authors.forename: A
authors.initials: A
authors.lastname: Amit
authors.forename: F
authors.initials: F
authors.lastname: Azem
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D015233:Models, Statistical; D009865:Oocytes / Q000166:cytology; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D016896:Treatment Outcome