title: Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones.
abstract: Triazinane diones, readily generated by a recently reported multicomponent reaction, can be easily alkylated with various alkyl halides, allowing a wide variety of complexity-generating secondary reactions. Because of the high variability of the initial multicomponent reactions and the multiple possibilities for participation of substituents in the secondary reactions, a highly diverse set of complex products was obtained in short and efficient reaction sequences.
authors.affiliation: Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands.
authors.forename: Bas
authors.initials: B
authors.lastname: Groenendaal
authors.forename: Eelco
authors.initials: E
authors.lastname: Ruijter
authors.forename: Frans J J
authors.initials: FJ
authors.lastname: de Kanter
authors.forename: Martin
authors.initials: M
authors.lastname: Lutz
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Spek
authors.forename: Romano V A
authors.initials: RV
authors.lastname: Orru
mesh_terms: D000478:Alkylation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D003500:Cyclization; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D007659:Ketones; D014227:Triazines