Cannabis use in Spanish patients with multiple sclerosis: fulfilment of patients' expectations?
OBJECTIVE
Medicinal use of cannabis in chronic neurological diseases is a controversial topic of medical research and the subject of intense public debate. The aim of the study was to evaluate the prevalence of cannabis use, related factors, and degree of satisfaction in Spanish patients with multiple sclerosis (MS) prior to the establishment of medically supervised use.


METHODS
Cross-sectional, questionnaire-based survey provided during routine medical visits to consecutive patients in two university-based neurology clinics.


RESULTS
The questionnaire was returned by 175 MS patients (94.1% response rate). The prevalence of ever-use and medicinal cannabis use were 43% and 17.1%, respectively. At the time of the survey, cannabis was being used by 12.5% (5/45) of recreational and 56.7% (17/30) of medical users (p<0.001). First cannabis consumption was after MS onset in 15 (50%) medicinal users. Clinical improvement was reported by 14 (46.7%) medicinal users. Smoking use, awareness of cannabis potential benefits, pain, higher disability, and lower age were independently associated with the medicinal use of cannabis. Most patients would support a future legalisation of cannabis for the control of their symptoms and were willing to receive cannabis under medical control once legalised (83.4% of never-users, 94.5% of ever-users, p<0.05).


CONCLUSIONS
Almost half of our MS patients had tried cannabis at some time. However, medicinal use was low and clinical improvement after cannabis use was only reported by a subset of patients. Overall, MS patients were highly motivated for a future medically controlled use.
Martínez-Rodríguez
Jose E
JE
Neurology Service, Hospital del Mar, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain. 33029jmr@comb.es
Munteis
Elvira
E
Carreño
Mar
M
Blanco
Yolanda
Y
Roquer
Jaume
J
Abanades
Sergio
S
Graus
Francesc
F
Saiz
Albert
A
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008385:Marijuana Smoking / Q000453:epidemiology* / Q000523:psychology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000523:psychology*; D015999:Multivariate Analysis; D016017:Odds Ratio; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology