title: GSK-3beta is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity.
authors.affiliation: Department of Microbiology & Immunology, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27858, USA. mccubreyj@ecu.edu
authors.forename: James A
authors.initials: JA
authors.lastname: McCubrey
authors.forename: Jörg
authors.initials: J
authors.lastname: Bäsecke
authors.forename: Melchiorre
authors.initials: M
authors.lastname: Cervello
authors.forename: Alberto M
authors.initials: AM
authors.lastname: Martelli
authors.forename: Richard A
authors.initials: RA
authors.lastname: Franklin
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis; D044182:Benzylisoquinolines / Q000494:pharmacology*; D045744:Cell Line, Tumor; D019938:Cyclin D1 / Q000378:metabolism; D050760:Cyclin-Dependent Kinase Inhibitor p27; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005786:Gene Expression Regulation; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D044182:Benzylisoquinolines; C436291:CDKN1B protein, human; D004791:Enzyme Inhibitors; D047908:Intracellular Signaling Peptides and Proteins; D019938:Cyclin D1; D050760:Cyclin-Dependent Kinase Inhibitor p27; C009438:tetrandrine; D019869:Phosphatidylinositol 3-Kinases; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3