Syndecan 1 (CD138) serum levels: a novel biomarker in predicting liver fibrosis stage in patients with hepatitis C.
OBJECTIVE
Syndecan 1 (CD 138) is a cell surface proteoglycan shed by cells in several pathological conditions, including wound healing. The aim of this study was to test whether CD138 could serve as a non-invasive marker for detection of liver fibrosis and thereby reduce the need for liver biopsy.


METHODS
An estimation set of 134 patients and a validation set of 67 patients with chronic hepatitis C were studied. There were 80 normal healthy volunteers. Patients were staged according to liver biopsies (Metavir fibrosis staging, stage F0, n=35; F1, n=40; F2, n=37, F3, n=39; F4, n=51). Serum CD138 levels were retrospectively measured by enzyme-linked immunoabsorbent assay the same day of the liver biopsy. The primary endpoints were the diagnostic values of CD138 for F2-F4, F3-F4 and F4.


RESULTS
Respective areas under receiver operating characteristic curve of CD138 for F2-F4, F3-F4 and F4 diagnosis were 0.82, 0.76 and 0.81. CD138 had a positive predictive value of 82% for F2-F4 diagnosis and a high negative predictive value (86%) and specificity (84%) for exclusion of F4.


CONCLUSIONS
CD138 is a new simple non-invasive marker for predicting liver fibrosis in patients with chronic hepatitis C. The relevance of this marker in combination with other fibrosis markers should be explored.
Zvibel
Isabel
I
Gastroenterology Institute and Liver Unit, Tel Aviv Sourasky Medical Center, Weizmann 6, Tel Aviv, Israel. isab@tasmc.health.gov.il
Halfon
Phillipe
P
Fishman
Sigal
S
Penaranda
Guillaume
G
Leshno
Moshe
M
Or
Anat Bet
AB
Halpern
Zamir
Z
Oren
Ran
R
D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood*; D001706:Biopsy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005602:France; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007557:Israel; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D053668:Syndecan-1 / Q000097:blood*
D015415:Biomarkers; C508241:SDC1 protein, human; D053668:Syndecan-1