title: Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny.
abstract: Effects of selank on learning, memory, and attention to sensory stimuli of different modality were studied in adult Wistar rats treated with 6-hydroxydopamine (neurotoxin selectively damaging catecholaminergic neurons and their terminals) during the first 3 days of life. Selank (300 microg/kg) restored cognitive processes disordered by chronic artificial inhibition of the cerebral catecholaminergic system.
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino.
authors.forename: T P
authors.initials: TP
authors.lastname: Semenova
authors.forename: M M
authors.initials: MM
authors.lastname: Kozlovskaya
authors.forename: N M
authors.initials: NM
authors.lastname: Zakharova
authors.forename: I I
authors.initials: II
authors.lastname: Kozlovskii
authors.forename: A V
authors.initials: AV
authors.lastname: Zuikov
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001288:Attention / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D002395:Catecholamines / Q000378:metabolism*; D005106:Exploratory Behavior / Q000187:drug effects; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000633:toxicity; D007274:Injections, Intraperitoneal; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009498:Neurotoxins / Q000008:administration & dosage / Q000633:toxicity; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D002395:Catecholamines; D006892:Hydroxydopamines; D009498:Neurotoxins; D009842:Oligopeptides; C100827:TP 7