title: Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture.
abstract: BACKGROUND
  Selective and non-selective cyclo-oxygenase (COX) inhibitors impair bone healing by inhibiting prostaglandin synthesis. The purpose of this study was to evaluate the long-term effect of parecoxib, a selective COX-2 inhibitor, on bone healing in rats, when it is applied in a pattern similar to clinical treatment patterns, that is, in a high dose and for a short period after bone fracture.
  
  
  METHODS
  Closed non-displaced mid-diaphyseal fractures in the middle of the left femoral shaft were generated in each animal. In the study group, parecoxib sodium (1.06 mg/kg) was administered intra-peritoneally every day for 7 days. In the control group, normal saline was administered intra-peritoneally every day for 7 days. In both groups fracture healing (bone union and callus formation) was evaluated with X-rays 28 and 42 days after surgery.
  
  
  RESULTS
  Bone healing was lower in the study group (60 vs. 80% in the control group 28 days after fracture and 80 vs. 90% 42 days after fracture) but this difference was not statistically significant (P > 0.05).
  
  
  CONCLUSIONS
  Parecoxib does not have a significant long-term effect on bone healing in rats, when it is administered in a high dose and for a short period after bone fracture.
authors.affiliation: Department of Pharmacology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Akritopoulos
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Papaioannidou
authors.forename: Ippokratis
authors.initials: I
authors.lastname: Hatzokos
authors.forename: Afroditi
authors.initials: A
authors.lastname: Haritanti
authors.forename: Eirini
authors.initials: E
authors.lastname: Iosifidou
authors.forename: Maria
authors.initials: M
authors.lastname: Kotoula
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Mirtsou-Fidani
mesh_terms: D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D005264:Femoral Fractures / Q000000981:diagnostic imaging / Q000601:surgery*; D005594:Fracture Fixation, Intramedullary; D017102:Fracture Healing / Q000187:drug effects*; D007555:Isoxazoles / Q000494:pharmacology*; D008297:Male; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016861:Cyclooxygenase Inhibitors; D007555:Isoxazoles; C409945:parecoxib