Gene expression, dose-response, and phenotypic anchoring: applications for toxicogenomics in risk assessment.
Daston
George P
GP
Central Product Safety, Procter & Gamble, Cincinnati, Ohio 45253, USA. daston.gp@pg.com
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde / Q000633:toxicity*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects*; D005838:Genotype; D006801:Humans; D009297:Nasal Mucosa / Q000187:drug effects* / Q000473:pathology; D010597:Pharmacogenetics; D010641:Phenotype; D012107:Research Design; D018570:Risk Assessment; D013997:Time Factors; D018675:Toxicity Tests; D014116:Toxicology / Q000379:methods*; D014158:Transcription, Genetic / Q000187:drug effects*
D005557:Formaldehyde