G-quadruplex recognition by bis-indole carboxamides.
Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.
Dash
Jyotirmayee
J
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Shirude
Pravin S
PS
Balasubramanian
Shankar
S
D000577:Amides / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D008024:Ligands; D011401:Promoter Regions, Genetic; D019009:Proto-Oncogene Proteins c-kit / Q000737:chemistry / Q000235:genetics; D016271:Proto-Oncogene Proteins c-myc / Q000737:chemistry / Q000235:genetics
D000577:Amides; D007211:Indoles; D008024:Ligands; D016271:Proto-Oncogene Proteins c-myc; D019009:Proto-Oncogene Proteins c-kit