Analyses of subjects with hypokalemic metabolic alkolosis, Gitelman's and Bartter's syndrome.
The two most common forms of inherited normotensive hypokalemic metabolic alkalosis are Bartter's and Gitelman's syndromes. Bartter's is mostly seen in children, while Gittelman's is mostly seen in adolescents and adults. We analyze three subjects of adult-onset Gitelman's and Bartter's syndrome. The patients applied to our hospital due to severe hypokalemia with little clinical expression (paresthesia, cramp, polyuria, polydipsia, and/or weakness). All had normal blood pressure, hypokalemia, hyperreninemic hyperaldosteronism, and a decrease in the fractional chloride reabsorption. Key elements in differential diagnosis of chronic hypokalemia are blood pressure assessment, acid base equilibrium, serum calcium concentration, and 24-hour urine potassium and calcium excretion.
Onem
Yalcin
Y
GATA Haydarpasa Teaching Hospital, Department of Internal Medicine, Istanbul, Turkey. yalonem@yahoo.com
Kucukardali
Yasar
Y
Sahan
Burak
B
Atasoyu
Enes Murat
EM
Ipcioğlu
Osman
O
Terekeci
Hakan
H
Solmazgul
Emrullah
E
Top
Cihan
C
Oktenli
Cagatay
C
D000293:Adolescent; D000328:Adult; D000471:Alkalosis / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D001477:Bartter Syndrome / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D005500:Follow-Up Studies; D053579:Gitelman Syndrome / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D007008:Hypokalemia / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D007213:Indomethacin / Q000008:administration & dosage; D007677:Kidney Function Tests; D008278:Magnesium Sulfate / Q000008:administration & dosage; D008297:Male; D011188:Potassium / Q000378:metabolism / Q000652:urine*; D011189:Potassium Chloride / Q000008:administration & dosage; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D016482:Urinalysis
D011189:Potassium Chloride; D008278:Magnesium Sulfate; D011188:Potassium; D007213:Indomethacin