title: Surviving sepsis campaign: a critical reappraisal.
abstract: In 2002, the declaration of Barcelona launched a worldwide campaign that proposed to decrease in sepsis-related mortality by the introduction of evidence-based medicine into the management of sepsis. This paved the way for the publication of a wide selection of recommendations entitled the Surviving Sepsis Campaign (SSC) Guidelines. Whereas most of the medical community received the guidelines with enthusiasm, dissonant voices were made public just after its publication, and in recent years, the SSC guidelines were a source of intense debate, resulting in a recent revision of the guidelines. In the midst of a large controversy, it is evident that a critical reappraisal of the SSC guidelines is timely. In our opinion, whereas many relevant aspects of the SSC guidelines have been discussed, there are three major limitations that deserve a closer look, and they are sepsis as a public health issue, the weight of the evidence behind the recommendations, and the absence of recommendations related to the prevention of sepsis. In conclusion, although we recognize that the SSC is a valuable initiative, many of its present aspects must be revised to provide a clear message for clinicians taking care of sepsis patients at bedside. New guidelines should be based on solid evidence, have no interference from the pharmaceutical or medical equipment industry, and should have a stronger preventive and public health approach.
authors.forename: Jorge I F
authors.initials: JI
authors.lastname: Salluh
authors.forename: Patrícia T
authors.initials: PT
authors.lastname: Bozza
authors.forename: Fernando A
authors.initials: FA
authors.lastname: Bozza
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D009102:Multiple Organ Failure / Q000628:therapy; D017410:Practice Guidelines as Topic; D011634:Public Health / Q000379:methods; D018805:Sepsis / Q000453:epidemiology / Q000401:mortality / Q000628:therapy*; D013030:Spain; D016896:Treatment Outcome