title: Mechanical and biological properties of nanoporous carbon membranes.
abstract: Implantable blood glucose sensors have inadequate membrane-tissue interfaces for long term use. Biofouling and inflammation processes restrict biosensor membrane stability. An ideal biosensor membrane material must prevent protein adsorption and exhibit cell compatibility. In addition, a membrane must exhibit high porosity and low thickness in order to allow the biosensor to respond to analyte fluctuations. In this study, the structural, mechanical and biological properties of nanoporous alumina membranes coated with diamond-like carbon thin films were examined using scanning probe microscopy, nanoindentation and MTT viability assay. We anticipate that this novel membrane material could find use in immunoisolation devices, kidney dialysis membranes and other medical devices encountering biocompatibility issues that limit in vivo function.
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599-7575, USA. roger narayan@unc.edu
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Narayan
authors.forename: Ravi
authors.initials: R
authors.lastname: Aggarwal
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Chunming
authors.initials: C
authors.lastname: Jin
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Monteiro-Riviere
authors.forename: Rene
authors.initials: R
authors.lastname: Crombez
authors.forename: Weidian
authors.initials: W
authors.lastname: Shen
mesh_terms: D002244:Carbon / Q000008:administration & dosage* / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004548:Elasticity; D006244:Hardness; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000187:drug effects*; D008422:Materials Testing; D008567:Membranes, Artificial; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D016062:Porosity; D013314:Stress, Mechanical; D013718:Tensile Strength
chemical_list: D008567:Membranes, Artificial; D002244:Carbon