title: Design, synthesis and DNA-cleaving efficiency of photoswitchable dimeric azobenzene-based C2-symmetric enediynes.
abstract: Designed azobenzene-based enediyne-amino acid C(2)-symmetric hybrids have been synthesized and the role of amino acid linker in stabilizing the Z form has been demonstrated; DNA-binding and cleavage studies have established higher reactivity of the Z-isomers.
authors.affiliation: Bioorganic Laboratory, Department of Chemistry, Indian Institute of Technology, Kharagpur, India. absk@chem.iitkgp.ernet.in
authors.forename: Amit
authors.initials: A
authors.lastname: Basak
authors.forename: Debarati
authors.initials: D
authors.lastname: Mitra
authors.forename: Moumita
authors.initials: M
authors.lastname: Kar
authors.forename: Kumar
authors.initials: K
authors.lastname: Biradha
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D053281:Enediynes / Q000737:chemistry / Q000494:pharmacology*; D009690:Nucleic Acid Conformation / Q000187:drug effects
chemical_list: D001391:Azo Compounds; D053281:Enediynes; D004247:DNA; C009850:azobenzene