Gene therapy of arthritis and orthopaedic disorders: current experimental approaches in China and in Canada.
BACKGROUND
Gene therapy offers new possibilities for the clinical management of orthopaedic conditions that are difficult to treat by traditional surgical or medical means.


OBJECTIVE
This review discusses the different gene therapy strategies available today, the safety issues with which they may be associated, and the potential for cooperation between China and Canada.


CONCLUSIONS
In the last decade, extensive improvements have been made to optimize gene therapy and have been tested on several orthopaedic conditions. China is a pioneer in some fields of gene therapy; the first anticancer gene therapy drug has been licensed in China. Canada has a very active research establishment and a populace that embraces new scientific developments, especially in medical sciences.
Dai
Ke-Rong
KR
Shanghai Jiao Tong University, Insititue of Health Sciences, School of Medicine, Chinese Academy of Sciences, 225 South Chongqing Road, Shanghai 200025, China.
Zhang
Xiao-Ling
XL
Shi
Qin
Q
Fernandes
Julio C
JC
D001168:Arthritis / Q000628:therapy*; D002170:Canada; D002681:China; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D007592:Joint Diseases / Q000628:therapy*