TGFbeta and SMADs talk to NANOG in human embryonic stem cells.
The TGFbeta/activin signaling pathway is important for the maintenance of human embryonic stem cells. In this issue of Cell Stem Cell, Xu et al. (2008) show that this pathway upregulates the expression of a key pluripotency gene NANOG through SMAD2/3.
Jiang
Jianming
J
Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672, Republic of Singapore.
Ng
Huck-Hui
HH
D001549:Benzamides / Q000494:pharmacology; D001665:Binding Sites / Q000235:genetics; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics; D049109:Cell Proliferation / Q000187:drug effects; D004149:Dioxoles / Q000494:pharmacology; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics* / Q000494:pharmacology; D009154:Mutation; D000071317:Nanog Homeobox Protein; D011401:Promoter Regions, Genetic; D011485:Protein Binding / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D051899:Smad2 Protein / Q000037:antagonists & inhibitors / Q000235:genetics*; D051900:Smad3 Protein / Q000037:antagonists & inhibitors / Q000235:genetics*; D015533:Transcriptional Activation / Q000187:drug effects / Q000235:genetics
C459179:4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide; D001549:Benzamides; D004149:Dioxoles; D018398:Homeodomain Proteins; D008233:Lymphotoxin-alpha; C486780:NANOG protein, human; D000071317:Nanog Homeobox Protein; D051899:Smad2 Protein; D051900:Smad3 Protein