title: Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats.
abstract: Osthole (1), an active constituent isolated from Cnidium monnieri (L.) Cusson, has been used in the treatment of diseases for many years in clinical. The aim of this present study was to determine the effect of 1 on protein expression of PPARalpha/gamma and related target molecules such as CYP7A and DGAT protein expression in the liver of hyperlipidemic fatty liver (HFL) rats, and to investigate the possible mechanism of treating HFL.
authors.affiliation: Department of Pharmacology, Medical School of Soochow University, Suzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Mei-Lin
authors.initials: ML
authors.lastname: Xie
authors.forename: Jie
authors.initials: J
authors.lastname: Xue
authors.forename: Zhen-Lun
authors.initials: ZL
authors.lastname: Gu
mesh_terms: D000818:Animals; D002790:Cholesterol 7-alpha-Hydroxylase / Q000235:genetics / Q000378:metabolism*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D051048:Diacylglycerol O-Acyltransferase / Q000235:genetics / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005234:Fatty Liver / Q000150:complications / Q000378:metabolism*; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008892:Milk; D015394:Molecular Structure; D047493:PPAR alpha / Q000378:metabolism*; D047495:PPAR gamma / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003374:Coumarins; D000960:Hypolipidemic Agents; D047493:PPAR alpha; D047495:PPAR gamma; C532838:CYP7A1 protein, rat; D002790:Cholesterol 7-alpha-Hydroxylase; C522579:Dgat2 protein, rat; D051048:Diacylglycerol O-Acyltransferase; C046627:osthol