Endoscope images of Schönlein-Henoch purpura.
OBJECTIVE
Schönlein-Henoch purpura (SHP) is a systemic condition characterized by purpura associated with leukocytoclastic vasculitis. SHP diagnosis is more difficult in infrequent cases where gastrointestinal (GI) symptoms precede purpura. This report examines 11 cases of SHP at our hospital with specific regard to the incidences and details of GI symptoms.


METHODS
The clinical manifestations and endoscopic findings were investigated for their utility in SHP diagnosis.


RESULTS
Among the 11 cases, 3 showed GI symptoms prior to other manifestations. In terms of GI symptoms, abdominal pain was reported in all 11 cases, diarrhea in 4 cases, and bloody stools in 3 cases. Endoscopic findings were seen in the stomach in 7/10 cases, in the small intestine including the duodenum in 10/11 cases, and in the large intestine in 6/10 cases. The frequency of ulcer formation was significantly higher in the small intestine (including the duodenum) than in the stomach. Multiple specific erythematosus lesions were observed in the stomach and large intestine.


CONCLUSIONS
Familiarity with characteristic endoscopic findings and careful observation of all GI findings are essential for diagnosing SHP in cases in which GI tract symptoms precede cutaneous findings.
Nishiyama
Ryu
R
Division of Gastroenterology and Hepatology, Nihon University School of Medicine, Tokyo, Japan. ryuwest@mb.infoweb.ne.jp
Nakajima
Noriko
N
Ogihara
Akifumi
A
Oota
Souichirou
S
Kobayashi
Shun
S
Yokoyama
Kiyoshi
K
Oonishi
Masahiko
M
Miyamoto
Shunpachi
S
Akai
Yuuichi
Y
Watanabe
Toshikazu
T
Uno
Akitake
A
Mizuno
Shigeaki
S
Ootani
Takeshi
T
Tanaka
Naohide
N
Moriyama
Mituhiko
M
D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D000368:Aged; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D066298:In Vitro Techniques; D007592:Joint Diseases / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000209:etiology*