title: Early pulse pressure and low-grade proteinuria as independent long-term risk factors for new-onset diabetes mellitus after kidney transplantation.
abstract: Risk factors for new-onset diabetes after transplantation (NODAT) need to be assessed in large cohorts. We retrospectively evaluated the impact of early (3 and 6 months after transplantation) proteinuria, urinary albumin excretion (UAE) and arterial pressure on NODAT in 828 Caucasian renal transplant recipients (median follow-up: 5.3 years; 5832 patient-years). The 10- and 20-year incidence of NODAT was 15.0% and 22.0%, respectively. Low-grade (<1 g/day) (HR: 2.04 [1.25-3.33], p = 0.0042) and very low-grade (<0.3 g/day) (HR: 2.21 [1.32-3.70], p = 0.0025) proteinuria were independent risk factors for NODAT. There was a dose-dependent relationship across UAE categories (increasing risk from normoalbuminuria to macroalbuminuria) with NODAT. Tacrolimus, sirolimus and beta-blockers (HR: 1.86 [1.07-3.22], p = 0.0277) were significantly associated with NODAT even after multiple adjustments, but not diuretics, angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers. Systolic arterial pressure (HR per 10 mmHg: 1.16 [1.03-1.29], p = 0.0126) and pulse pressure (HR: 1.26 [1.12-1.43], p = 0.0002) were associated with NODAT. Only pulse pressure remained significant after adjustments. Patients at highest risks had early proteinuria and pulse pressure >60 mmHg. Early low-grade proteinuria and pulse pressure (in addition to beta-blockers) constitute independent risk factors for NODAT; they may be markers of the metabolic syndrome and/or vascular damage in renal transplant recipients.
authors.affiliation: Service de Néphrologie-Immunologie Clinique, Hôpital Bretonneau, CHRU Tours, Tours, France.
authors.forename: M
authors.initials: M
authors.lastname: Roland
authors.forename: P
authors.initials: P
authors.lastname: Gatault
authors.forename: A
authors.initials: A
authors.lastname: Al-Najjar
authors.forename: C
authors.initials: C
authors.lastname: Doute
authors.forename: C
authors.initials: C
authors.lastname: Barbet
authors.forename: V
authors.initials: V
authors.lastname: Chatelet
authors.forename: I
authors.initials: I
authors.lastname: Laouad
authors.forename: J-F
authors.initials: JF
authors.lastname: Marlière
authors.forename: H
authors.initials: H
authors.lastname: Nivet
authors.forename: M
authors.initials: M
authors.lastname: Büchler
authors.forename: Y
authors.initials: Y
authors.lastname: Lebranchu
authors.forename: J-M
authors.initials: JM
authors.lastname: Halimi
mesh_terms: D000328:Adult; D015415:Biomarkers; D001794:Blood Pressure; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000503:physiopathology*; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers