title: Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population.
abstract: OBJECTIVE
  It has recently been shown that the neuronal sortilin-related receptor (SORL1) plays an important role in the pathogenesis of Alzheimer's disease (AD).
  
  
  METHODS
  To investigate whether variations around the SORL1 gene are associated with AD, 7 single-nucleotide polymorphisms (SNPs) were genotyped using TaqMan technology with 180 AD patients and 130 age-matched controls.
  
  
  RESULTS
  Our results confirmed the strong linkage disequilibrium among the 7 SNPs studied. However, our study failed to detect any association between the SNPs and AD. We could not confirm any synergetic interaction between the SNPs and apolipoprotein E in our AD patients either.
  
  
  CONCLUSIONS
  Further genetic studies are needed to clarify the relationship between the SORL1 gene and AD.
authors.affiliation: Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan. nobuto.shibata@nifty.ne.jp
authors.forename: Nobuto
authors.initials: N
authors.lastname: Shibata
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohnuma
authors.forename: Hajime
authors.initials: H
authors.lastname: Baba
authors.forename: Shinji
authors.initials: S
authors.lastname: Higashi
authors.forename: Kenya
authors.initials: K
authors.lastname: Nishioka
authors.forename: Heii
authors.initials: H
authors.lastname: Arai
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000208:ethnology* / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D044466:Asian People / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D026502:LDL-Receptor Related Proteins / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D053327:Apolipoprotein E4; D026502:LDL-Receptor Related Proteins; D026901:Membrane Transport Proteins; C102582:SORL1 protein, human