Progression of a sessile serrated adenoma to an early invasive cancer within 8 months.
Recent studies suggest that serrated polyps, including hyperplastic polyps, traditional serrated adenomas, and sessile serrated adenomas, may be morphologically and genetically distinct and linked to microsatellite unstable colorectal cancers, and thus the concept of a hyperplastic polyp-serrate adenoma-carcinoma pathway has been suggested. Furthermore, it has been suggested that transformation from serrated polyps to invasive cancers can be rapid and occurs when the lesions are small; however, direct evidence for this issue is scant. We herein describe a case of a sessile serrated adenoma showing rapid transformation into a submucosal invasive carcinoma with remarkable morphological change in a short period of 8 months. This case is unique and suggestive, as it provided information about the natural history of a sessile serrated adenoma.
Oono
Yasuhiro
Y
Department of Gastroenterology, Tokyo Metropolitan Tama Cancer Detection Center, Tokyo, Japan.
Fu
Kuangi
K
Nakamura
Hisashi
H
Iriguchi
Yosuke
Y
Yamamura
Akihiko
A
Tomino
Yasuhiro
Y
Oda
Johji
J
Mizutani
Masaru
M
Takayanagi
Satoshi
S
Kishi
Daisuke
D
Shinohara
Tomoaki
T
Yamada
Kozo
K
Matumoto
Jun
J
Imamura
Kazuhiro
K
D000236:Adenoma / Q000473:pathology*; D000368:Aged; D002277:Carcinoma / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D008297:Male; D013997:Time Factors