title: Cytotoxic lanostanoid triterpenes from Ganoderma lucidum.
abstract: Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic acid (1), and 12beta-acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8-25 microm.
authors.affiliation: Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Shanghai Research Center for TCM Modernization, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Guan
authors.forename: Jia-Meng
authors.initials: JM
authors.lastname: Xia
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Wang
authors.forename: Xuan
authors.initials: X
authors.lastname: Liu
authors.forename: De-An
authors.initials: DA
authors.lastname: Guo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D020940:Reishi / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: C532704:12beta-acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20E-diene-26-oic acid; C532703:23S-hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic acid; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes