Triazole-linked host compounds for chiral-discrimination toward amino acid ester guests.
The chiral-discriminating abilities of new triazole-linked host compounds (6, 7) toward amino acid esters were evaluated by the FABMS/EL-guest method. Two types of host appending saccharide derivatives were synthesized by the copper-catalyzed Huisgen-1,3-dipolar cycloaddition (CuAAC). Host compounds binding constants and chiral-discriminating abilities toward the enantiomeric alanine esters were evaluated by UV method in chloroform. The structural requirements of triazole-linked hosts were determined by their chiral-discriminating behaviors.
Sato
Hirofumi
H
Department of Biochemistry, Osaka Municipal Technical Research Institute, Japan. hsato@omtri.city.osaka.jp
Shizuma
Motohiro
M
D000409:Alanine / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D001665:Binding Sites; D002725:Chloroform / Q000737:chemistry; D004952:Esters / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry*
D000596:Amino Acids; D004952:Esters; D014230:Triazoles; D002725:Chloroform; D000409:Alanine