Population structure analysis of the Mycobacterium tuberculosis Beijing family indicates an association between certain sublineages and multidrug resistance.
Our population-based study of the Mycobacterium tuberculosis Beijing family examined the frequency of occurrence of each sublineage of this family, classified by using 10 synonymous single-nucleotide polymorphisms. The results revealed the overabundance of two evolutionary sublineages in a population of multidrug-resistant and extensively drug-resistant tuberculosis bacteria.
Iwamoto
Tomotada
T
Department of Microbiology, Kobe Institute of Health, Kobe 650-0046, Japan. kx2t-iwmt@asahi-net.or.jp
Yoshida
Shiomi
S
Suzuki
Katsuhiro
K
Wada
Takayuki
T
D000328:Adult; D000368:Aged; D015373:Bacterial Typing Techniques; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D020641:Polymorphism, Single Nucleotide; D013045:Species Specificity; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology