Nickel-catalyzed highly regioselective multicomponent coupling of ynamides, aldehydes, and silane: a new access to functionalized enamides.
A new method for preparation of functionalized enamides by a nickel-catalyzed multicomponent coupling of ynamides, aldehydes, and silane has been developed. The coupling reaction proceeded in the presence of a nickel-IMes catalyst to give the corresponding gamma-silyloxyenamide derivative, which has an allylic alcohol moiety in the molecule, in a highly stereoselective manner.
Saito
Nozomi
N
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Katayama
Tomoyuki
T
Sato
Yoshihiro
Y
D000447:Aldehydes / Q000737:chemistry*; D000475:Alkenes / Q000138:chemical synthesis*; D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis*; D002384:Catalysis; D008958:Models, Molecular; D009532:Nickel / Q000737:chemistry; D023303:Oxazolidinones / Q000737:chemistry; D012821:Silanes / Q000737:chemistry*
D000447:Aldehydes; D000475:Alkenes; D000480:Alkynes; D000577:Amides; D023303:Oxazolidinones; D012821:Silanes; D009532:Nickel