title: Chiral peptide nucleic acid monomers (PNAM) with modified backbones.
abstract: Convenient high yielding syntheses of optically pure PNAMs comprising l- or d-serine, l-lysine and l-arginine units linked to thymine or Cbz-cytosine are described. Simple workup and inexpensive reagents are employed and free amino acids are used as coupling components.
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
authors.forename: Alan Roy
authors.initials: AR
authors.lastname: Katritzky
authors.forename: Tamari
authors.initials: T
authors.lastname: Narindoshvili
mesh_terms: D000215:Acylation; D000596:Amino Acids / Q000737:chemistry*; D001120:Arginine / Q000737:chemistry*; D003596:Cytosine / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008239:Lysine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D012694:Serine / Q000737:chemistry*; D013941:Thymine / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D020135:Peptide Nucleic Acids; D012694:Serine; D003596:Cytosine; D004247:DNA; D001120:Arginine; D008239:Lysine; D013941:Thymine