title: High incidence of thrombotic complications early after liver transplantation for familial amyloidotic polyneuropathy.
abstract: Early thrombotic complications are critical causes of in-hospital morbidity after orthotopic liver transplantation (OLT), potentially culminating in graft loss. The aim of this study was to retrospectively analyse these complications, trying to identify associated independent risk factors. This retrospective analysis included 223 OLTs performed on 213 patients, in a 30-month period. Eighty-six OLTs were performed on familial amyloidotic polyneuropathy (FAP) patients. Preoperative details (primary diagnosis and Child-Turcotte-Pugh classification, when applicable), surgical features (including type of arterial reconstruction), postoperative variables and outcome were analysed. The observation period ended 30 days post-OLT, until discharge or in-hospital death. Early thrombotic complications were diagnosed in 16 cases (7.2%), affecting mainly FAP patients (n = 12). Hepatic artery thrombosis (HAT) was the most frequent early thrombotic event (n = 12): incidence in FAP patients 11.6% (n = 10) versus incidence in non FAP patients 1.5% (n = 2), P = 0.001. By logistic regression analysis, FAP turned out to be an independent risk factor for early thrombotic complications, and specifically for HAT. The type of arterial reconstruction and other analysed surgical and medical factors did not influence early HAT occurrence. In conclusion, FAP was identified in this study as an independent risk factor for early HAT, a new datum not yet described in the literature.
authors.affiliation: Intensive-Care Unit, Curry Cabral Hospital, Lisbon, Portugal. gastregas@hegasmoniz.min-saude.pt
authors.forename: Miguel
authors.initials: M
authors.lastname: Bispo
authors.forename: Paulo
authors.initials: P
authors.lastname: Marcelino
authors.forename: António
authors.initials: A
authors.lastname: Freire
authors.forename: Américo
authors.initials: A
authors.lastname: Martins
authors.forename: Luís
authors.initials: L
authors.lastname: Mourão
authors.forename: Eduardo
authors.initials: E
authors.lastname: Barroso
mesh_terms: D000328:Adult; D000368:Aged; D028227:Amyloid Neuropathies, Familial / Q000150:complications*; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D015994:Incidence; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013927:Thrombosis / Q000453:epidemiology* / Q000209:etiology; D055815:Young Adult