Cytokines as a key component of cancer-related inflammation.
Inflammatory conditions in some tissues increase the risk of cancer. Cytokines and chemokines are components of an intensive dialog promoting angiogenesis, metastasis, subversion of adaptive immunity and changing response to hormones and to chemotherapeutic agents. Cytokines involved in cancer-related inflammation represent a target for innovative diagnostic and therapeutic strategies, and a future challenge for scientists and clinicians.
Germano
Giovanni
G
Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, Milan, Italy.
Allavena
Paola
P
Mantovani
Alberto
A
D018925:Chemokines / Q000502:physiology; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D007375:Interleukin-1 / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D009369:Neoplasms / Q000503:physiopathology*; D009389:Neovascularization, Pathologic; D017472:Receptors, Interleukin-1 / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D018925:Chemokines; D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D017472:Receptors, Interleukin-1; D014409:Tumor Necrosis Factor-alpha