A study on the seroconversion in dogs vaccinated with cell culture rabies vaccine.
Seroconversion studies were conducted in dogs vaccinated with rabies vaccine, of different age group, sex and breed, with a single and booster doses of cell culture Rabies vaccine. The results of the present study revealed that (i) Maternal antibodies were detected in 40% to 80% of 60 selected pet dogs. However 20% to 60% of the pet dogs did not have protective levels of antibody (<0.5IU). (ii) A single dose of vaccine resulted in appreciable levels of protective antibody in 100% of pet dogs both in seronegetive and in dogs with low levels of antibody. (iii) When a booster dose was administered at twelve months period, considerable levels of antibody persisted upto twenty-four months. It can be concluded from the present study that a single dose of potent tissue culture vaccine resulted protective levels of antibody in the seronegetive dogs (<0.5IU). In an Rabies endemic country like INDIA, annual booster dose of vaccine would enhance the immune response and help in the persistence of protective levels of antibody in the immunized dogs.
Ramanna
B C
BC
Brilliant Industries Limited, Vaccine Division, Hyderabad. ID-bcramanna@rediffmail.com
Swain
Amit kumar
Ak
Wakankar
C C
CC
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D018929:Cell Culture Techniques; D004285:Dogs; D004334:Drug Administration Schedule / Q000662:veterinary; D005260:Female; D008297:Male; D011819:Rabies Vaccines / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary*
D000914:Antibodies, Viral; D011819:Rabies Vaccines