Platelet-monocyte interactions--a dangerous liaison linking thrombosis, inflammation and atherosclerosis.
Atherosclerosis is an inflammatory disease. Monocyte-platelet interactions may play a key role in this process by various pathways. They "inflame" each other as well as adjacent cell types at the vascular wall by direct physical interactions, autocrine and paracrine activation processes. These processes promote monocyte recruitment (in)to the vascular wall--a key mechanism in atherogenesis. This article highlights the molecular basis and the inflammatory pathways initiated by platelet-monocyte interactions.
Seizer
Peter
P
Medizinische Klinik III, Eberhard Karls Universität Tübingen, Otfried-Müller Strasse 10, Tübingen, Germany.
Gawaz
Meinrad
M
May
Andreas E
AE
D050197:Atherosclerosis / Q000097:blood* / Q000209:etiology* / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism*; D001808:Blood Vessels / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000378:metabolism; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism; D016177:Macrophage-1 Antigen / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism*; D019899:Paracrine Communication; D015398:Signal Transduction; D013927:Thrombosis / Q000097:blood* / Q000209:etiology* / Q000378:metabolism
D016169:Lymphocyte Function-Associated Antigen-1; D016177:Macrophage-1 Antigen; D008562:Membrane Glycoproteins; C084882:P-selectin ligand protein