title: Highly pathogenic avian influenza virus (H5N1) in experimentally infected adult mute swans.
abstract: Adult, healthy mute swans were experimentally infected with highly pathogenic avian influenza virus A/Cygnus cygnus/Germany/R65/2006 subtype H5N1. Immunologically naive birds died, whereas animals with preexisting, naturally acquired avian influenza virus-specific antibodies became infected asymptomatically and shed virus. Adult mute swans are highly susceptible, excrete virus, and can be clinically protected by preexposure immunity.
authors.affiliation: Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
authors.forename: Donata
authors.initials: D
authors.lastname: Kalthoff
authors.forename: Angele
authors.initials: A
authors.lastname: Breithaupt
authors.forename: Jens P
authors.initials: JP
authors.lastname: Teifke
authors.forename: Anja
authors.initials: A
authors.lastname: Globig
authors.forename: Timm
authors.initials: T
authors.lastname: Harder
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Mettenleiter
authors.forename: Martin
authors.initials: M
authors.lastname: Beer
mesh_terms: D000818:Animals; D046090:Anseriformes / Q000821:virology*; D000914:Antibodies, Viral / Q000276:immunology; D001921:Brain / Q000821:virology; D005123:Eye / Q000821:virology; D005260:Female; D053124:Influenza A Virus, H5N1 Subtype / Q000502:physiology*; D005585:Influenza in Birds / Q000276:immunology / Q000401:mortality / Q000821:virology*; D008099:Liver / Q000821:virology; D008297:Male; D012367:RNA, Viral / Q000302:isolation & purification; D012867:Skin / Q000821:virology; D013997:Time Factors; D019562:Viral Load; D014779:Virus Replication; D017201:Virus Shedding
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral