Cardioprotective effect of aqueous extract of Embelia ribes Burm fruits against isoproterenol-induced myocardial infarction in albino rats.
In the present study, cardioprotective effect of aqueous extract of fruits of Embelia ribes Burm (ER) was evaluated in a rat model having acute myocardial infarction, induced by isoproterenol (5.25 and 8.5 mg/kg, sc, for two consecutive days). Aqueous ER extract (100 mg/kg) pretreatment orally for 40 days in isoproterenol (ISO)-treated rats significantly decreased the heart rate, systolic blood pressure, increased levels of serum lactate dehydrogenase, serum creatine kinase and myocardial lipid peroxides and significantly increased the myocardial endogenous antioxidants (glutathione, superoxide dismutase and catalase) levels. The results of biochemical observations in serum and heart tissues were supplemented by histopathological examination of rat's heart sections to confirm the myocardial injury. The results were comparable to that of gliclazide treated group. The present results provide evidence for the first time, that aqueous ER extract pretreatment ameliorated myocardial injury and enhanced the antioxidant defense against ISO-induced myocardial infarction in rats and exhibited cardioprotective property.
Bhandari
Uma
U
Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi 110 062, India. uma_bora@hotmail.com
Ansari
M Nazam
MN
Islam
F
F
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001794:Blood Pressure; D031645:Embelia / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry; D005978:Glutathione / Q000378:metabolism; D006439:Hemodynamics; D007545:Isoproterenol / Q000494:pharmacology*; D008055:Lipids / Q000737:chemistry; D008954:Models, Biological; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control*; D009206:Myocardium / Q000473:pathology*; D010636:Phenols / Q000737:chemistry; D010936:Plant Extracts / Q000378:metabolism*; D059808:Polyphenols; D051381:Rats; D013481:Superoxides / Q000378:metabolism
D000975:Antioxidants; D005419:Flavonoids; D008055:Lipids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D013481:Superoxides; D005978:Glutathione; D007545:Isoproterenol