Preimplantation aneuploidy testing for infertile patients of advanced maternal age: a randomized prospective trial.
OBJECTIVE
To assess the potential benefit of preimplantation aneuploidy testing on the outcome of in vitro fertilization (IVF) for women of advanced maternal age (AMA).


METHODS
Prospective randomized clinical trial.


METHODS
Private IVF clinic.


METHODS
Sixty-two infertile AMA couples undergoing fertility treatment.


METHODS
Fluorescent in situ hybridization (FISH) for chromosomes X, Y, 13, 15, 16, 17, 18, 21, and 22.


METHODS
Preimplantation aneuploidy testing of biopsied blastomeres on day 3 of development.


RESULTS
Fertilization and blastocyst developmental rates were similar for the test and control groups: 80% versus 77.4% and 49% versus 48.2%, respectively. The average number of embryos transferred was comparable at 2.2 for the test group and 2.7 for the control group. Implantation rates were also equivalent across the two groups: 37.3% in the control group versus 36.5% in the test group. Nevertheless, the spontaneous abortion rate was observed to be lower for the test group: 25.9% versus 32.26% in the control group. This resulted in an observed increase in delivery rates for the test group: 78% versus 67.74% in the control group.


CONCLUSIONS
Preimplantation aneuploidy testing does not appear to statistically significantly improve outcome parameters in infertile AMA patients; however, a trend toward a decrease in the spontaneous abortion rate with a subsequent higher delivery rate was observed.
Schoolcraft
William B
WB
Colorado Center for Reproductive Medicine, 10290 RidgeGate Circle, Lone Tree, CO 80124, USA. wschoolcraft@colocrm.com
Katz-Jaffe
Mandy G
MG
Stevens
John
J
Rawlins
Mary
M
Munne
Santiago
S
D000328:Adult; D000782:Aneuploidy; D001706:Biopsy; D001757:Blastomeres / Q000166:cytology / Q000502:physiology*; D002877:Chromosomes, Human; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008423:Maternal Age; D009865:Oocytes / Q000166:cytology / Q000502:physiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D019836:Preimplantation Diagnosis; D011446:Prospective Studies