title: Chromofluorescent indicator for intracellular Zn2+/Hg2+ dynamic exchange.
abstract: The fluorescence of NABQ increases remarkably in the presence of Zn(2+) and is quenched by Hg(2+). As shown by confocal imaging, NABQ-Zn(2+) can penetrate cells, where the bound Zn(2+) is exchanged for Hg(2+). This results in the concomitant export of Hg(2+) from the cells, showing that NABQ can act as a Zn(2+) carrier and as a Hg(2+) extracting agent in living cells.
authors.affiliation: Department of Chemistry, Korea University, Seoul 136-701, Korea.
authors.forename: Jeong Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Hyo Sung
authors.initials: HS
authors.lastname: Jung
authors.forename: Pil Seung
authors.initials: PS
authors.lastname: Kwon
authors.forename: Jong Wan
authors.initials: JW
authors.lastname: Kim
authors.forename: Richard A
authors.initials: RA
authors.lastname: Bartsch
authors.forename: Youngmee
authors.initials: Y
authors.lastname: Kim
authors.forename: Sung-Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000818:Animals; D002413:Cations, Divalent / Q000737:chemistry; D002460:Cell Line; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D008628:Mercury / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D011798:Quinaldines / Q000138:chemical synthesis / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry; D015032:Zinc / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D000096926:Benzenesulfonamides
chemical_list: D002413:Cations, Divalent; D005456:Fluorescent Dyes; D008628:Mercury; D011798:Quinaldines; D013449:Sulfonamides; D015032:Zinc; D000096926:Benzenesulfonamides