[The indices of pro- and antioxidant state of the gastro-esophageal junction tissues in experimental gastroesophageal reflux disease].
Experimental investigation on studying of pro- and antioxidant state in esophageal tissues was performed. It was established, that accumulation of products of the proteins and lipids oxidation during inflammatory process course coincides with significant lowering of the antioxidant enzymes activity. The data obtained trusts the various diagnostic significance of diienic conjugates and malonic dialdehyde (MDA) levels. The increase of MDA concentration as well as of products of the oxidational modifications proteins, owing basic character, was revealed as a typical biochemical marker of acid-peptic injury of esophageal tissues.
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D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D004195:Disease Models, Animal; D004942:Esophagitis, Peptic / Q000201:enzymology / Q000378:metabolism*; D004943:Esophagogastric Junction / Q000201:enzymology / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides