[Prevalence of nonalcoholic fatty liver disease in patients with polycystic ovary syndrome: a case-control study].
OBJECTIVE
To explore the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with polycystic ovary syndrome (PCOS).


METHODS
A case-control study employing 60 nonpregnant patients with PCOS and 60 non-pregnant patients without PCOS as control was conducted to compare the prevalence of NAFLD.


RESULTS
The aminotransferase (ALT), fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) levels were (29 +/- 15) U/L, (19 +/- 12) mU/L and 0.47 +/- 0.29 in PCOS group, which were significantly higher (P < 0.05) than corresponding parameters in control group [(15 +/- 13) U/L, (11 +/- 8) mU/L and 0.31 +/- 0.21)]. The occurrence of insulin resistance and NAFLD was63% (38/60) and 42% (25/60), higher than those in control group [35% (21/60) and 20% (12/60), P < 0.05]. The increment of ALT was 40% (24/60) in PCOS group, higher than that of 3% (2/60) in control group (P < 0.01). Compared with patients without NAFLD, patients with NAFLD had significantly increased body mass index (P < 0.01), waist-hip ratio, ALT, C-reaction protein, fasting insulin, insulin and HOMA-IR levels 2 hours after oral glucose tolerance test (P < 0. 05).


CONCLUSIONS
The increased prevalence of NAFLD in PCOS patients suggests an association between these two conditions and the necessity of hepatic screening among PCOS patients for potential NAFLD.
Zheng
Ruo-Heng
RH
Department of Reproduction, Zhejiang Integrated Traditional and Western Medicine Hospital, Hangzhou 310003, China.
Ding
Cai-Fei
CF
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D005234:Fatty Liver / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D049629:Waist-Hip Ratio; D055815:Young Adult
D007328:Insulin; D000410:Alanine Transaminase