title: Community-associated methicillin-resistant Staphylococcus aureus infective endocarditis with Panton-Valentine leukocidin gene in an injection drug user with HIV infection.
abstract: Reports of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates carrying Panton-Valentine leukocidin (PVL) gene that causes infective endocarditis in injection drug users (IDUs) with human immunodeficiency virus (HIV) infection are rare in the English language literature. We present a case of CA-MRSA infective endocarditis with bilateral septic lung emboli in a previously healthy 45-year-old IDU. This case suggests that PVL gene-positive CA-MRSA should be considered as a potential pathogen in IDUs with infective endocarditis.
authors.affiliation: Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China.
authors.forename: Hung-Chin
authors.initials: HC
authors.lastname: Tsai
authors.forename: Pei-Jiuan
authors.initials: PJ
authors.lastname: Chao
authors.forename: Cheng-Len
authors.initials: CL
authors.lastname: Sy
authors.forename: Susan Shin-Jung
authors.initials: SS
authors.lastname: Lee
authors.forename: Yao-Shen
authors.initials: YS
authors.lastname: Chen
authors.forename: Shue-Ren
authors.initials: SR
authors.lastname: Wann
authors.forename: Yung-Ching
authors.initials: YC
authors.lastname: Liu
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000235:genetics*; D017714:Community-Acquired Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000209:etiology* / Q000382:microbiology; D005098:Exotoxins / Q000235:genetics*; D015658:HIV Infections; D006801:Humans; D007956:Leukocidins / Q000235:genetics*; D008297:Male; D008712:Methicillin / Q000627:therapeutic use; D016106:Methicillin Resistance; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity; D015819:Substance Abuse, Intravenous
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D008712:Methicillin