title: Disseminated intravascular coagulation following induction of labour with misoprostol: a case report.
abstract: BACKGROUND
  Disseminated Intravascular coagulopathy (DIC) has been reported following use of Misoprostol which is an old drug with new indications in Obstetrics and Gynecology. Its effectiveness, low cost, stability in tropical conditions and ease of administration as well as side effects like gastrointestinal effect, uterine rupture and post partum haemorrhage (PPH) have been documented.
  
  
  METHODS
  This is to report a case of disseminated intravascular coagulopathy (DIC) associated with use of misoprostol for induction of labour and to call for extra vigilance in its use.
  
  
  RESULTS
  This was a case of 22-year old gravida 2 para 1 at 42 weeks gestation that was induced with 100 microg of misoprostol and delivered a live female baby with good Apgar score. She subsequently developed PPH and epistaxis simultaneously, then conjunctival haemorrhage 30 minutes later. She was managed with fresh whole blood and had a satisfactory recovery.
  
  
  CONCLUSIONS
  Life threatening complication could result from use of Misoprostol. More research and high index of suspicion are needed to establish the association of prostaglandins with DIC.
authors.affiliation: Federal Medical Centre, Azare. unibrahim2000@yahoo.co.uk
authors.forename: N I
authors.initials: NI
authors.lastname: Umar
authors.forename: M A
authors.initials: MA
authors.lastname: Abdul
authors.forename: T A
authors.initials: TA
authors.lastname: Jido
authors.forename: J
authors.initials: J
authors.lastname: Tukur
authors.forename: L M
authors.initials: LM
authors.lastname: Dattijo
mesh_terms: D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000209:etiology*; D005130:Eye Hemorrhage / Q000209:etiology; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000009:adverse effects*; D016595:Misoprostol; D010120:Oxytocics; D006473:Postpartum Hemorrhage / Q000209:etiology
chemical_list: D010120:Oxytocics; D016595:Misoprostol