Genetic screening in infertile Mexican men: chromosomal abnormalities, Y chromosome deletions, and androgen receptor CAG repeat length.
In our study, we analyzed chromosomal abnormalities, Y chromosome deletions, androgen receptor CAG repeat length and their association with defective spermatogenesis in infertile Mexican men. Eighty-two infertile patients and 40 controls were screened for karyotypic abnormalities, Y chromosome microdeletions, and CAG repeats. Nine infertile males (11%) carried chromosomal abnormalities and 10 (12.2%) presented Y chromosome microdeletions. The mean CAG repeat length was 21.6 and 20.88 base pairs in idiopathic infertile males and controls, respectively. Our results suggest that chromosomal aberrations and Y-chromosomal microdeletions are related to male infertility in Mexican men. In addition, expansion of the CAG repeat segments of the androgen receptor is not correlated with male idiopathic infertility.
Martínez-Garza
Sandra Guadalupe
SG
Instituto de Ciencias en Reproducción Humana Vida (Instituto Vida), Plaza Las Américas 115, Col Jardines del Moral, León, Guanajuato, México CP 37160. samartin30@yahoo.com
Gallegos-Rivas
Mayra Celina
MC
Vargas-Maciel
Marcos
M
Rubio-Rubio
Juan Manuel
JM
de Los Monteros-Rodríguez
Mario Espinosa
ME
González-Ortega
Claudia
C
Cancino-Villarreal
Patricia
P
de Lara
Luis G Vazquez
LG
Gutiérrez-Gutiérrez
Antonio Martín
AM
D000328:Adult; D002869:Chromosome Aberrations; D041322:Chromosomes, Human, Y / Q000235:genetics*; D020732:Cytogenetic Analysis; D005820:Genetic Testing; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008800:Mexico; D011944:Receptors, Androgen / Q000235:genetics*; D019680:Trinucleotide Repeat Expansion / Q000235:genetics*
D011944:Receptors, Androgen