Determination of sub-ppb cadmium in urine by solid-phase extraction and inductively coupled plasma-mass spectrometry.
In order to determine low levels of Cd in urine samples, we tried to remove Mo interference using ICP-MS with a dynamic reaction-cell technique, but failed due to the low sensitivity and the variance with the standards. We then performed solid-phase extraction (SPE) before the ICP-MS measurement. A commercially available chelating resin, NOBIAS PA-1, was used for SPE, and could effectively remove Mo from urine samples, permitting the accurate determination of Cd by ICP-MS. This SPE-ICP-MS method gave 0.012 microg Cd L(-1) as the method limit of quantification, and the mean recovery of Cd spiked with 0.0505 and 5.05 microg L(-1) was 93.1 and 97.6%, respectively.
Suzuki
Yoshihiro
Y
Research Center for Occupational Poisoning, Tokyo Rosai Hospital, Japan Labour Health and Welfare Organization, Ohta, Tokyo 143-0013, Japan.
Endo
Yoko
Y
Ogawa
Masanori
M
Matsuda
Michiko
M
Nakajima
Yoshiaki
Y
Onda
Nobuhiko
N
Iwasaki
Motoki
M
Tsugane
Shoichiro
S
D002104:Cadmium / Q000652:urine*; D013058:Mass Spectrometry / Q000379:methods*; D008982:Molybdenum / Q000737:chemistry / Q000302:isolation & purification; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D052616:Solid Phase Extraction / Q000379:methods*
D002104:Cadmium; D008982:Molybdenum