Beyond genetics: surprising determinants of cell fate in antitumor drugs.
In this issue of Cancer Cell, Gascoigne and Taylor (2008) report their findings of following 10,000 single cells incubated with three classes of antimitotic drugs, including paclitaxel (taxol). This extensive analysis reveals a previously unappreciated complexity in response to such drugs and demonstrates that it is more than genetics that determines cell life or death.
Holland
Andrew J
AJ
Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0670, USA.
Cleveland
Don W
DW
D000970:Antineoplastic Agents / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D019070:Cell Lineage / Q000187:drug effects*; D043171:Chromosomal Instability / Q000187:drug effects; D005823:Genetics; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology; D008941:Spindle Apparatus / Q000187:drug effects / Q000378:metabolism
D000970:Antineoplastic Agents