Hemispheric asymmetry of speed-dependent intercerebellar connectivity.
The coordinated and timed movements of human limbs require interactive cerebellar functions. We investigated the function of intercerebellar connectivity in controlling the movement speed of both hands with functional MRI experiments. Nine healthy, right-handed subjects performed finger movements at lower and higher speeds, as instructed. With finger movements at a higher speed, regional responses in the bilateral cerebellum were increased in both hands. However, the contribution of the ipsilateral cerebellum to the contralateral cerebellum, which was assessed by psychophysiological interaction analysis, was increased only in the dominant hand. Results of this study indicated that there is a speed-dependent modulation of intercerebellar connectivity for finger movement and this modulation has hemispheric asymmetry.
Park
Chang-hyun
CH
Department of Physical Medicine and Rehabilitation, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Kim
Soo Yong
SY
Ohn
Suk Hoon
SH
Lee
Bo-Hyun
BH
Kim
Sung Tae
ST
Kim
Yun-Hee
YH
D000328:Adult; D001931:Brain Mapping; D002531:Cerebellum / Q000098:blood supply / Q000502:physiology*; D005260:Female; D005385:Fingers / Q000294:innervation; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D009415:Nerve Net / Q000098:blood supply / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D011597:Psychomotor Performance / Q000502:physiology; D011601:Psychophysics
D010100:Oxygen