Expanded adipose-derived stem cells for the treatment of complex perianal fistula including Crohn's disease.
BACKGROUND
Complex perianal fistulising disease is a distressing condition. In patients without Crohn's disease, surgery is the mainstay treatment but faecal incontinence and recurrence are high. Infliximab is used in Crohn's patients but not all respond to therapy.


OBJECTIVE
After an evaluation of the current treatment options, we discuss studies of adipose-derived stem cell (ASC) therapy, a novel approach for treating complex perianal fistulas.


METHODS
ASCs are obtained from a liposuction procedure and a subsequent expansion process. They are administered according to a strict protocol which involves infusion of the cells into the target lesion along with fibrin glue.


CONCLUSIONS
A Phase IIb study comparing ASC and fibrin glue therapy with fibrin glue therapy alone showed that ASCs were effective at inducing healing in complex perianal fistulas.
Garcia-Olmo
Damian
D
Hospital Universitario La Paz, Servicio de Cirugía General, Paseo de la Castellana 261, 28046 Madrid, Spain. damian.garcia@uam.es
Garcia-Arranz
Mariano
M
Herreros
Dolores
D
D000273:Adipose Tissue / Q000166:cytology*; D002986:Clinical Trials as Topic; D003424:Crohn Disease / Q000628:therapy*; D006801:Humans; D012003:Rectal Fistula / Q000628:therapy*; D013234:Stem Cells / Q000166:cytology*