Chromatographic NMR in NMR solvents.
Recently, it was demonstrated that pseudo-chromatographic NMR experiments could be performed using typical chromatographic solids and solvents. This first setup yielded improved separation of the spectral components of the NMR spectra of mixtures using PFG self-diffusion measurements. The method (dubbed Chromatographic NMR) was successively shown to possess, in favorable cases, superior resolving power on non-functionalized silica, compared to its LC counterpart. To further investigate the applicability of the method, we studied here the feasibility of Chromatographic NMR in common deuterated solvents. Two examples are provided, using deuterated chloroform and water, for homologous compounds soluble in these solvents, namely aromatic molecules and alcohols, respectively.
Carrara
Caroline
C
ISm2 UMR 6263, Aix Marseille Université, Campus Saint Jérôme, 13013 Marseille, France.
Viel
Stéphane
S
Delaurent
Corinne
C
Ziarelli
Fabio
F
Excoffier
Grégory
G
Caldarelli
Stefano
S
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012822:Silicon Dioxide / Q000737:chemistry*; D012996:Solutions; D012997:Solvents / Q000737:chemistry*; D013048:Specimen Handling / Q000379:methods*
D012996:Solutions; D012997:Solvents; D012822:Silicon Dioxide