title: Computer-based visual evaluation as a screening tool after intravitreal injections of vascular endothelial growth factor inhibitors.
abstract: OBJECTIVE
  To evaluate the visual acuity (VA) of patients following intravitreal (IVT) injections.
  
  
  METHODS
  15 patients received 3 anti-vascular-endothelial-growth-factor (VEGF) injections on a monthly basis. Prior to each injection as well as 2 months after, the patients received a standardized examination including Snellen VA and optical coherence tomography (OCT). During this time the patients were trained to evaluate their central VA by 3 computer-based tests: (a) VA was examined by the patient on a computer-based vision chart and (b) subjectively categorized as 'same', 'worse' or 'better'; (c) the edge of metamorphopsia was outlined on a digital Amsler grid.
  
  
  RESULTS
  VA improved during the 3 injections by >or=2 lines (13/15). The assessment demonstrated subjective improvement (13/15), i.e. a gain of 2 or more lines or decreased central metamorphopsia (12/15). Reevaluation 2 months later demonstrated a decline of >or=1 Snellen line or increased retinal thickness on OCT (8/15), and a decline of >or=1 line or an enlarged metamorphopsia in the computer-based tests (6/15).
  
  
  CONCLUSIONS
  Our pilot study demonstrated a good correlation between the professional examination and the computer-based assessment. Selected patients can define their visual impairment. A web-based VA evaluation may help to screen patients after IVT injections on a regular basis at home.
authors.affiliation: Department of Ophthalmology, Philipps-University, Marburg, Germany. meyer_eye@yahoo.com
authors.forename: Carsten H
authors.initials: CH
authors.lastname: Meyer
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Lapolice
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008268:Macular Degeneration / Q000175:diagnosis* / Q000188:drug therapy; D010865:Pilot Projects; D015203:Reproducibility of Results; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*; D015351:Vision Screening / Q000379:methods*; D014792:Visual Acuity / Q000187:drug effects / Q000502:physiology; D014822:Vitreous Body
chemical_list: D020533:Angiogenesis Inhibitors; D042461:Vascular Endothelial Growth Factor A