title: Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus.
abstract: Stevens-Johnson syndrome (SJS) is a serious and potentially life-threatening disease. Vanishing bile duct syndrome (VBDS) is a rare cause of progressive cholestasis. Both syndromes are mostly related with drugs. We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature. It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus. This case reminds physicians of the importance of drug reactions, their severity, techniques for diagnosis and methods of management.
authors.affiliation: Gastroenterohepatology Department, Acibadem Bakirkoy Hospital, Istanbul, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Okan
authors.forename: Serpil
authors.initials: S
authors.lastname: Yaylaci
authors.forename: Onder
authors.initials: O
authors.lastname: Peker
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Kaymakoglu
authors.forename: Murat
authors.initials: M
authors.lastname: Saruc
mesh_terms: D000328:Adult; D001649:Bile Duct Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D002939:Ciprofloxacin / Q000009:adverse effects* / Q000627:therapeutic use; D003680:Deglutition Disorders / Q000188:drug therapy; D053159:Dysuria / Q000188:drug therapy; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D016559:Tacrolimus / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D002939:Ciprofloxacin; D016559:Tacrolimus