title: Warfarin-associated intracerebral hemorrhage.
abstract: Intracerebral hemorrhage (ICH) is the most serious complication of oral anticoagulant therapy (OAT), with mortality in excess of 50%. Major risk factors are advanced patient age, elevated systolic blood pressure, intensity of anticoagulation, and previous cerebral ischemia. A number of acute treatments are available, but all have significant side effects and no randomized clinical trials assessing clinical outcome have been performed. Future trials will have to address choice and dose of agent, the timing of its administration, and the risk of side effects.
authors.affiliation: UC Malattie Cerebrovascolari/Stroke Unit IRCCS Fondazione Istituto Neurologico C. Mondino, Via Mondino 2, 27100, Pavia, Italy. anna.cavallini@mondino.it
authors.forename: Anna
authors.initials: A
authors.lastname: Cavallini
authors.forename: Simona
authors.initials: S
authors.lastname: Fanucchi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Persico
mesh_terms: D000367:Age Factors; D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D002536:Cerebral Arteries / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology*; D003029:Coagulants / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D042241:Early Diagnosis; D006801:Humans; D012307:Risk Factors; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D003029:Coagulants; D014859:Warfarin