title: Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: application to pharmacokinetic studies.
abstract: Mulberry 1-deoxynojirimycin (DNJ) is a potent alpha-glucosidase inhibitor. Although it is useful for the treatment of diabetes, the human absorption and metabolism of DNJ have never been characterized. We developed a method using hydrophilic interaction chromatography coupled with ion trap tandem mass spectrometry, and found that orally administered DNJ was absorbed into the blood and then excreted into the urine.
authors.affiliation: Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan. nkgw@biochem.tohoku.ac.jp
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kubota
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tsuzuki
authors.forename: Jun
authors.initials: J
authors.lastname: Kariya
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kimura
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oikawa
authors.forename: Teruo
authors.initials: T
authors.lastname: Miyazawa
mesh_terms: D017485:1-Deoxynojirimycin / Q000097:blood* / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D007477:Ions / Q000737:chemistry; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D053719:Tandem Mass Spectrometry
chemical_list: D007477:Ions; D017485:1-Deoxynojirimycin