title: Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas aeruginosa.
abstract: The pvc gene cluster from Pseudomonas aeruginosa has been linked to the biosynthesis of both the pyoverdine chromophore and pseudoverdine. Our reinvestigation of the role this gene cluster plays in P. aeruginosa secondary metabolite biosynthesis shows that its major product is actually paerucumarin, a novel isonitrile functionalized cumarin.
authors.affiliation: Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Clarke-Pearson
authors.forename: Sean F
authors.initials: SF
authors.lastname: Brady
mesh_terms: D003374:Coumarins / Q000378:metabolism*; D005798:Genes, Bacterial; D013058:Mass Spectrometry; D053858:Metabolic Networks and Pathways / Q000235:genetics; D005810:Multigene Family; D009842:Oligopeptides / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000378:metabolism*; D014468:Umbelliferones / Q000378:metabolism
chemical_list: D003374:Coumarins; D009842:Oligopeptides; D014468:Umbelliferones; C083007:pseudoverdin; C042453:pyoverdin