Macrolide-resistant Shigella sonnei.
Shigella sonnei UCN59, isolated during an outbreak of S. sonnei in January 2007, was resistant to azithromycin (MIC 64 mg/L). The isolate contained a plasmid-borne mph(A) gene encoding a macrolide 2 -phosphotransferase that inactivates macrolides. Emergence of the mph(A) gene in S. sonnei may limit usefulness of azithromycin for treatment of shigellosis.
Boumghar-Bourtchai
Leyla
L
Centre Hospitalier Universitaire Côte de Nacre, Caen, France.
Mariani-Kurkdjian
Patricia
P
Bingen
Edouard
E
Filliol
Ingrid
I
Dhalluin
Anne
A
Ifrane
Shadia Ait
SA
Weill
François-Xavier
FX
Leclercq
Roland
R
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002675:Child, Preschool; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial; D004405:Dysentery, Bacillary / Q000382:microbiology; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012764:Shigella sonnei / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D018942:Macrolides