Differential expression of dysadherin in papillary thyroid carcinoma and microcarcinoma: correlation with E-cadherin.
Dysadherin is a novel glycoprotein, with an anti-cell-cell adhesion function. The aim of the present study was to examine the expression of dysadherin in thyroid papillary microcarcinoma (PMC), to associate it with the expression of E-cadherin and to investigate whether there are differences with papillary carcinoma (PC). A statistically significant difference in dysadherin and E-cadherin expression between PC and PMC and a negative correlation between E-cadherin and dysadherin expression regardless of tumor size were noted. Based on these findings it is hypothesized that retained cell-cell adhesion, through maintenance of the E-cadherin adhesion system, in PMC prevents neoplastic cells from dissociating easily from each other and metastasizing. Increased dysadherin expression is possibly one of the post-transcriptional mechanisms responsible for E-cadherin downregulation in thyroid papillary neoplasia.
Batistatou
Anna
A
Department of Pathology, University of Ioannina Medical School, University Campus, P.O. Box 1186, 451 10, Ioannina, Greece. abatista@cc.uoi.gr
Charalabopoulos
Konstantinos
K
Nakanishi
Yukihiro
Y
Vagianos
Constantine
C
Hirohashi
Setsuo
S
Agnantis
Niki J
NJ
Scopa
Chrissoula D
CD
D015820:Cadherins / Q000378:metabolism*; D018265:Carcinoma, Papillary, Follicular / Q000378:metabolism* / Q000473:pathology*; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D007473:Ion Channels; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D008840:Microfilament Proteins; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology*
D015820:Cadherins; C451410:FXYD5 protein, human; D007473:Ion Channels; D008562:Membrane Glycoproteins; D008840:Microfilament Proteins; D009363:Neoplasm Proteins