Complexation study on no-carrier-added astatine with insulin: a candidate radiopharmaceutical.
No-carrier-added astatine radionuclides produced in the (7)Li-irradiated lead matrix were separated from bulk lead nitrate target by complexing At with insulin, followed by dialysis. The method offers simultaneous separation of At from lead as well as its complexation with insulin. The At-insulin complex might be a potential radiopharmaceutical in the treatment of hepatocellular carcinoma. The stability of At-insulin complex was checked by dialysis against deionized water and Ringer lactate (RL) solution. It has been found that the half-life of At-insulin complex is about approximately 12h, when dialyzed against deionized water and is only 6h, when dialyzed against RL solution having the same composition as blood serum. The 6h half-life of this Insulin-At complex is perfect for killing cancer cells from external cell surfaces as the half-life of internalization of insulin molecule inside the cell is 7-12h.
Lahiri
Susanta
S
Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700 064, India. susanta.lahiri@saha.ac.in
Roy
Kamalika
K
Sen
Souvik
S
D001246:Astatine / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D007328:Insulin / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
D004337:Drug Carriers; D007328:Insulin; D019275:Radiopharmaceuticals; D001246:Astatine