Left ventricular systolic and diastolic function and carotid intima-media thickness in pediatric dialysis patients.
BACKGROUND
Cardiovascular complications are common in patients with end-stage renal disease (ESRD). We aimed to investigate left ventricular (LV) function and carotid intima-media thickness (cIMT) in children and adolescents with ESRD.


METHODS
This study included 38 ESRD patients (15 hemodialysis and 23 peritoneal dialysis) and 17 age- and sex-matched healthy subjects.


RESULTS
The ESRD patients had significantly lower mean mitral E/A ratio, and higher left ventricular mass index (LVMI) and cIMT than the control group. Compared with PD patients, HD patients had worse LV diastolic function. In stepwise linear regression analysis, LVMI (P = 0.043) and hemoglobin (P = 0.015) turned out to be independent variables for predicting diastolic dysfunction (reduced E/A ratio), and the only significant predictor of cIMT was indexed diastolic blood pressure (DBP) (P = 0.035).


CONCLUSIONS
Cardiovascular structure and function abnormalities are also common in pediatric dialysis patients, as in adults. Furthermore our data indicated that hemodialysis was disadvantageous for preserving LV diastolic function as compared with peritoneal dialysis.
Civilibal
Mahmut
M
Department of Pediatric Nephrology, Istanbul University Cerrahpasa Medical Faculty, Cerrahpasa, 34303 Istanbul, Turkey. drcivilibal@hotmail.com
Oflaz
Huseyin
H
Caliskan
Salim
S
Candan
Cengiz
C
Canpolat
Nur
N
Pehlivan
Gulseren
G
Sever
Lale
L
Kasapcopur
Ozgur
O
Arisoy
Nil
N
D000293:Adolescent; D002318:Cardiovascular Diseases / Q000209:etiology; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D006435:Renal Dialysis; D012307:Risk Factors; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000502:physiology*; D055815:Young Adult