title: Morbid obesity is associated with lower clinical pregnancy rates after in vitro fertilization in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To determine whether morbid obesity is associated with decreased pregnancy and live birth rates after IVF in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  University-based fertility center.
  
  
  METHODS
  Seventy-two women with PCOS who completed their first IVF cycle between 2001 and 2006.
  
  
  METHODS
  Outcomes of IVF were compared between women with a body mass index (BMI) of <40 kg/m(2) vs. those with a BMI of > or =40 kg/m(2).
  
  
  METHODS
  Clinical pregnancy rate, live birth rate.
  
  
  RESULTS
  Morbidly obese women with PCOS (n = 19) had significantly lower clinical pregnancy rates after IVF than patients with PCOS who were not morbidly obese (n = 53) (32% vs. 72%, relative risk 0.44, 95% confidence interval 0.22-0.87). Their live birth rates were lower too, although this difference was not statistically significant (32% vs. 60%, relative risk 0.52, 95% confidence interval 0.26-1.05).
  
  
  CONCLUSIONS
  Morbid obesity is associated with lower pregnancy rates in women with PCOS after IVF, raising the question of whether weight loss may improve IVF success rates for morbidly obese PCOS patients.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Washington University in Saint Louis, Saint Louis, MO 63108, USA. jungheime@wustl.edu
authors.forename: Emily S
authors.initials: ES
authors.lastname: Jungheim
authors.forename: Susan E
authors.initials: SE
authors.lastname: Lanzendorf
authors.forename: Randall R
authors.initials: RR
authors.lastname: Odem
authors.forename: Kelle H
authors.initials: KH
authors.lastname: Moley
authors.forename: Aimee S
authors.initials: AS
authors.lastname: Chang
authors.forename: Valerie S
authors.initials: VS
authors.lastname: Ratts
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth / Q000453:epidemiology*; D009767:Obesity, Morbid / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D018873:Pregnancy Rate; D012016:Reference Values; D012189:Retrospective Studies; D012306:Risk