[Allergy and neurotoxicity induced by bee sting. Case report and literature review].
Under the heading of this subject we deal with stings by arthropods, making of bees, commenting on the composition of the poisons and the different local and general reactions that are differences that exist between the stings The venom contains many biologically active components such as melitin, phospholipase A2, apamin, mast cell degranulation peptide, hyaluronidase, histamine, and dopamine. That neurotoxic venom secretory phospholipases A2 (sPLA2) have specific receptors in brain membranes called N-type receptors that are likely to play a role in the molecular events leading to neurotoxicity of these proteins. The sPLA2 found in honeybee venom is neurotoxic and binds to this receptor with high affinity. Poneratoxin is small neuropeptide found in the venom of arthropod (bee). It is stored in the venom reservoir as a inactive 25 residue peptide. Here we describe both chemically synthesized poneratoxin, insect larvae were paralyzed by injection of either of the purified toxins. These toxins are used in research as molecular probes, targeting with high affinity selected ion channel subtypes. As such, they are very useful for understanding the mechanism of synaptic transmission. Poneratoxin affects the voltage-dependent sodium channels and blocks the synaptic transmission in the insect central nervous system in a concentration-dependent manner; we think that in the human this is same.
Valencia Zavala
Martha Patricia
MP
Servicio de Alergia e Inmunología Clínica, Hospital General de México. mipsins@hotmail.com
Sánchez Olivas
Jesús Alberto
JA
Sánchez Olivas
Manuel Anastasio
MA
Montes Montes
José
J
Duarte Díaz
Rosa Janet
RJ
León Oviedo
Cristóbal
C
D000707:Anaphylaxis / Q000139:chemically induced*; D000818:Animals; D001514:Bee Venoms / Q000009:adverse effects*; D001516:Bees; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D007299:Insect Bites and Stings / Q000150:complications*; D008297:Male; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000175:diagnosis* / Q000209:etiology*
D001514:Bee Venoms