title: [The advances in research on phosphorylation of polyglutamine disease].
abstract: Polyglutamine (polyQ) diseases are a group of hereditary neurodegenerative disorders caused by expansion of a glutamine repeat in responsible gene products. To date, the pathogenesis of polyQ diseases is still not very clear, but many researches suggest that phosphorylation of mutant proteins plays a critical role on the process of Huntington's disease, dentatorubral-pallidoluysian atrophy, spinal bulbar muscular atrophy, spinocerebellar ataxia1 and spinocerebellar ataxia 3/Machado-Joseph disease.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 People's Republic of China.
authors.forename: Ya-fang
authors.initials: YF
authors.lastname: Zhou
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Jian-guang
authors.initials: JG
authors.lastname: Tang
authors.forename: Bei-sha
authors.initials: BS
authors.lastname: Tang
mesh_terms: D020271:Heredodegenerative Disorders, Nervous System / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000378:metabolism; D017827:Machado-Joseph Disease / Q000235:genetics / Q000378:metabolism; D009134:Muscular Atrophy, Spinal; D010455:Peptides / Q000235:genetics* / Q000378:metabolism*; D010766:Phosphorylation / Q000502:physiology*; D013132:Spinocerebellar Degenerations / Q000235:genetics / Q000378:metabolism; D019680:Trinucleotide Repeat Expansion / Q000235:genetics* / Q000502:physiology; D018911:Trinucleotide Repeats / Q000235:genetics
chemical_list: D010455:Peptides; C097188:polyglutamine