title: [Development of anti-malarial vaccines and need for clinical trials in accordance with international standards in South Africa].
abstract: In the 20th century malaria remains a major problem of public health in sub-Saharan Africa. This haemosporidium discovered in Africa by Laveran in 1880, kills one child every 30 seconds which amounts to three "tsunami" flowing each year into the African continent. The current international solidarity raises new hopes as regards the possibility to suppress the morbidity effects on the population's health condition. In order to be efficient, today's strategies (impregnated mosquito nets, intermittent preventive treatments, artemisinin based combination therapy) should reach at least 80% of the targeted population (pregnant women and children). By 2025, the uncontrolled urbanization of the African population and the social disorders will make a new population a target for malaria. The new data of functional genomics and proteonics open new avenues of research for new mechanisms, new therapeutics and vaccine targets and new tools of diagnosis and prognosis. The current candidate vaccines of the first generation have allowed the development of African competences in clinical trials of international standard. Although they represent scientific advances they will not resolve the problem of public health. Research on candidate vaccines of 2nd and 3rd generation remains a challenge for the international scientific community. Africa should play a determining role in this process. Scientific information on the field remains essential for these generations of new anti-malarial vaccines. The ethical aspects regarding those clinical trials and actions of public health and research remain an universal necessity Deontology and ethics are two complementary approaches for the good practice of medicine and research of a good practitioner. For the protection and advantages of the patient and/or volunteer of the research are the cornerstones of the ethical approach. The scientific quality of a research protocol submitted to an independent research ethics committee and the volunteer 's informed consent are universal ethical obligations. For the quality of ethics observance in a country reflects best the quality of the efficiency of its research system and its democracy.
authors.affiliation: Malaria Research and Training Center, Département d'epidémiologie des affections parasitaires, Faculté de médecine, de pharmacie et d'odonto-stomatologie du Mali, Université de Bamako, BP 1805, Bamako, Mali.
authors.forename: O K
authors.initials: OK
authors.lastname: Doumbo
authors.forename: A A
authors.initials: AA
authors.lastname: Djimdé
authors.forename: M A
authors.initials: MA
authors.lastname: Théra
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D000818:Animals; D002986:Clinical Trials as Topic / Q000941:ethics / Q000592:standards*; D006801:Humans; D008288:Malaria / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*; D017780:Malaria Vaccines; D010961:Plasmodium / Q000737:chemistry / Q000235:genetics / Q000276:immunology
chemical_list: D017780:Malaria Vaccines