title: Successful long-term monotherapy with rituximab in a patient with chronic lymphocytic leukemia of the B-cell-lineage: a case report.
abstract: BACKGROUND
  Treatment of chronic lymphocytic leukemia of the B-cell-lineage is strongly based upon clinical staging because of the heterogeneous clinical course of this disease.
  
  
  METHODS
  We describe a 62-year-old patient with newly diagnosed chronic lymphocytic leukemia of the B-cell-lineage who did not respond to several chemotherapy regimens including chlorambucil, fludarabine and cyclophosphamide, developing a marked neutropenia and thrombocytopenia with life-threatening infections. Further chemotherapy appeared not feasible because of bone marrow toxicity. The patient was treated with 600 mg/m2 rituximab weekly followed by eight courses of biweekly therapy and then by long-term maintenance therapy, achieving almost complete remission of the symptoms and disease control.
  
  
  CONCLUSIONS
  After resistance to standard chemotherapy with chlorambucil and fludarabine, a patient with chronic lymphocytic leukemia of the B-cell-lineage was successfully treated with rituximab.
authors.affiliation: Department of Hematology and Oncology, Charité Campus Virchow-Klinikum, Berlin, Germany. isrid.sturm@charite.de
authors.forename: Isrid
authors.initials: I
authors.lastname: Sturm
authors.forename: Joachim
authors.initials: J
authors.lastname: Oertel
authors.forename: Stephan
authors.initials: S
authors.lastname: Oertel
authors.forename: Jörg
authors.initials: J
authors.lastname: Westermann
authors.forename: Antonio
authors.initials: A
authors.lastname: Pezzutto