title: A longitudinal study of comparison of the Kato-Katz technique and indirect hemagglutination assay (IHA) for the detection of schistosomiasis japonica in China, 2001-2006.
abstract: From 2001 to 2006, about one-third of the residents aged 5-65 years were selected as the subjects in a schistosome-endemic village located in Jiangxi Province, China. Every 1 year, all participants were analyzed by the Kato-Katz parasitologic examination and indirect hemagglutination assay (IHA). Statistical analysis of the results showed the k indices ranged from 0.250 to 0.347 between the two methods. Assuming the Kato-Katz results as the gold standard reference, the specificity of the IHA was from 60% to 77%, the positive predictive value of this method was from 19% to 30%, and its sensitivity and negative predictive value were more than 97%. The IHA method is unsuitable for individual screening in endemic community with relatively high prevalence (e.g. with >10% or more prevalence). A search for a better diagnostic test that can be applied in field situations in China is essential and should be given high priority.
authors.affiliation: Department of Epidemiology, School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China. z yibiao@hotmail.com
authors.forename: Yi-Biao
authors.initials: YB
authors.lastname: Zhou
authors.forename: Mei-Xia
authors.initials: MX
authors.lastname: Yang
authors.forename: Po
authors.initials: P
authors.lastname: Tao
authors.forename: Qiu-Lin
authors.initials: QL
authors.lastname: Jiang
authors.forename: Gen-Ming
authors.initials: GM
authors.lastname: Zhao
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Wei
authors.forename: Qing-Wu
authors.initials: QW
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D006386:Hemagglutination Tests / Q000379:methods; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D010274:Parasitology / Q000379:methods; D011237:Predictive Value of Tests; D012549:Schistosoma japonicum / Q000302:isolation & purification*; D012554:Schistosomiasis japonica / Q000175:diagnosis* / Q000453:epidemiology; D012680:Sensitivity and Specificity