Chiral peptide nucleic acid monomers (PNAM) with modified backbones.
Convenient high yielding syntheses of optically pure PNAMs comprising l- or d-serine, l-lysine and l-arginine units linked to thymine or Cbz-cytosine are described. Simple workup and inexpensive reagents are employed and free amino acids are used as coupling components.
Katritzky
Alan Roy
AR
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
Narindoshvili
Tamari
T
D000215:Acylation; D000596:Amino Acids / Q000737:chemistry*; D001120:Arginine / Q000737:chemistry*; D003596:Cytosine / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008239:Lysine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D012694:Serine / Q000737:chemistry*; D013941:Thymine / Q000737:chemistry*
D000596:Amino Acids; D020135:Peptide Nucleic Acids; D012694:Serine; D003596:Cytosine; D004247:DNA; D001120:Arginine; D008239:Lysine; D013941:Thymine