[Progress in the study of the chemical synapse in glioma-associated epileptogenesis].
Seizures may be the first or sometimes the only manifestation of patients with glioma in clinics. The aim of operation is to eliminate epilepsy far beyond mere resection of tumor mass. The underlying mechanisms of glioma-associated epileptogenesis are poorly understood. Recently the theory of amino-acid like neurotransmitters in chemical synapse is gradually accepted. However, the molecular mechanisms remain to be further investigated on how glutamate release is regulated and how synaptic homeostasis in peripheral neurons is kept or disturbed. So detailed studies are needed to clarify specific molecular target and provide proper evidence for optimal antiepileptic drugs in glioma-associated epileptogenesis.
Sun
Hong-zan
HZ
Department of Radiology, Shengjing Hospital of China Medical University, Shengyang, China.
Fan
Guo-guang
GG
Wang
Gui-ling
GL
Guo
Qi-yong
QY
D001932:Brain Neoplasms / Q000150:complications* / Q000378:metabolism; D004827:Epilepsy / Q000209:etiology*; D005910:Glioma / Q000150:complications* / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism; D050479:Neurotransmitter Transport Proteins / Q000378:metabolism*; D013569:Synapses / Q000737:chemistry*
D018377:Neurotransmitter Agents; D050479:Neurotransmitter Transport Proteins; D018698:Glutamic Acid