Role of ion channel modifiers in reversal of morphine-induced gastrointestinal inertia by prokinetic agents in mice.
Prokinetic drugs like mosapride, domperidone etc, are used to treat gastrointestinal delay. Though the receptor-mediated actions of these agents have been studied, involvement of ion channels in reversing morphine-induced gastrointestinal inertia by prokinetic agents has not been explored. Charcoal meal test was used to measure small intestinal transit (SIT) in adult male Swiss albino mice. Animals were given ion channel modifiers and prokinetic drugs intragastrically. Reversal of morphine-induced gastrointestinal delay by mosapride was decreased significantly by CaCl2, minoxidil and glibenclamide. Similarly, domperidone's effect on morphine was decreased by CaCl2, nifedipine, minoxidil and glibenclamide significantly. The results reveal that ion channel modifiers counteract the prokinetic effects of mosapride or domperidone.
Sandhiya
Selvarajan
S
Department of Pharmacology, JIPMER, Puducherry 605006, India. sandhiyaselvarajan@yahoo.com
Dkhar
Steven Aibor
SA
Krishna
Peddy Reddy Murali
PR
Ramaswamy
Subramanian
S
D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D015220:Calcium Channels / Q000378:metabolism; D004294:Domperidone / Q000494:pharmacology; D041981:Gastrointestinal Tract / Q000378:metabolism*; D005905:Glyburide / Q000494:pharmacology; D007421:Intestine, Small / Q000187:drug effects; D007473:Ion Channels / Q000378:metabolism; D007700:Kinetics; D051379:Mice; D008914:Minoxidil / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology*; D009025:Morpholines / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology; D013997:Time Factors
D000701:Analgesics, Opioid; D001549:Benzamides; D015220:Calcium Channels; D007473:Ion Channels; D009025:Morpholines; D004294:Domperidone; D008914:Minoxidil; D009020:Morphine; C062720:mosapride; D009543:Nifedipine; D005905:Glyburide