title: Bordetella pertussis filamentous hemagglutinin delivered by mucosal routes enhances immunoglobulin levels in serum and mucosal fluids.
abstract: Free Bordetella pertussis filamentous hemagglutinin (FHA) can act as an adjuvant for mucosally administrated antigens. Here, we show that independently of the adjuvant properties of FHA toward an unrelated antigen, total IgG or IgA concentrations in serum and mucosal fluids are enhanced by the administration of FHA. Oral administration of FHA increases both total IgG concentrations in serum and total immunoglobulin concentrations in intestinal lavages. Nasal administration of FHA increases total IgA concentrations in broncho-alveolar lavages. FHA induces Langerhans cell recruitment and MIP-3alpha mRNA expression within hours after administration. These observations shed a new light on the potential molecular mechanisms of FHA-induced adjuvanticity.
authors.affiliation: INSERM U547, Lille, Cedex, France. odile.poulain@good.ibl.fr
authors.forename: Odile
authors.initials: O
authors.lastname: Poulain-Godefroy
authors.forename: Catherine
authors.initials: C
authors.lastname: Vendeville
authors.forename: Camille
authors.initials: C
authors.lastname: Locht
authors.forename: Gilles
authors.initials: G
authors.lastname: Riveau
mesh_terms: D018829:Adhesins, Bacterial / Q000008:administration & dosage* / Q000276:immunology*; D000276:Adjuvants, Immunologic; D000281:Administration, Intranasal; D000818:Animals; D021461:Animals, Outbred Strains; D000907:Antibodies, Bacterial / Q000032:analysis / Q000097:blood; D001826:Body Fluids / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology*; D005260:Female; D007070:Immunoglobulin A / Q000032:analysis / Q000097:blood; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood; D051379:Mice; D009092:Mucous Membrane / Q000276:immunology*; D010566:Virulence Factors, Bordetella / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D018829:Adhesins, Bacterial; D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D010566:Virulence Factors, Bordetella; C065273:filamentous hemagglutinin adhesin, Bordetella pertussis