title: Tau aggregates and tau pathology.
abstract: There is controversy in some neurodegenerative disorders whether the presence of aberrant aggregates in a neuron could have a toxic or a protective effect. In some disorders like in encephalopathies (prion disease), protein aggregates are toxic for the neuron. In other disorders, like Huntington disease, a protective role has been suggested for the aggregates of huntingtin. In this paper, we review the role of tau aggregation and hypothesize that tau aggregates could have an insufficient protective role in damaged neurons.
authors.affiliation: Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Madrid, Spain.
authors.forename: Félix
authors.initials: F
authors.lastname: Hernández
authors.forename: Jesús
authors.initials: J
authors.lastname: Avila
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology; D000818:Animals; D006801:Humans; D019636:Neurodegenerative Diseases / Q000473:pathology*; D016874:Neurofibrillary Tangles / Q000473:pathology; D016875:tau Proteins / Q000737:chemistry* / Q000502:physiology / Q000633:toxicity*
chemical_list: D016875:tau Proteins