title: In vivo protein delivery to human liver-derived cells using hepatitis B virus envelope pre-S region.
abstract: Human hepatocyte-specific delivery of green fluorescent protein was succeeded in the mouse xenograft model by fusion with hepatitis B virus surface antigen pre-S regions (pre-S(1+2)), not with each pre-S region. The entire pre-S region would be useful for human liver-specific delivery of therapeutic proteins and bio-imaging fluoroproteins in biomedical field.
authors.affiliation: Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kasuya
authors.forename: Tadanori
authors.initials: T
authors.lastname: Yamada
authors.forename: Atsuko
authors.initials: A
authors.lastname: Uyeda
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Toshihide
authors.initials: T
authors.lastname: Okajima
authors.forename: Kenji
authors.initials: K
authors.lastname: Tatematsu
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Tanizawa
authors.forename: Shun'ichi
authors.initials: S
authors.lastname: Kuroda
mesh_terms: D002460:Cell Line; D002478:Cells, Cultured; D016503:Drug Delivery Systems / Q000379:methods*; D006515:Hepatitis B virus / Q000378:metabolism*; D022781:Hepatocytes / Q000378:metabolism*; D006801:Humans; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry*; D014759:Viral Envelope Proteins / Q000737:chemistry* / Q000493:pharmacokinetics*
chemical_list: D010455:Peptides; D014759:Viral Envelope Proteins