title: Radiotherapy for small-cell lung cancer-Where are we heading?
abstract: Radiotherapy has an established role in the management of limited-disease small-cell lung cancer. However, essential questions related to the optimisation of thoracic radiotherapy remain unanswered including (i) optimal total dose, (ii) fractionation, (iii) timing and sequencing of radiation, (iv) volume of irradiation, and (v) concurrent chemotherapy combinations. The role of thoracic radiotherapy for extensive-disease small-cell lung cancer is more poorly understood but evidence suggests radiotherapy may have an important role in this setting. This review highlights the need for well-designed multi-national trials aimed at the optimisation and standardisation of radiotherapy for SCLC.
authors.affiliation: Department of Clinical Oncology, Christie Hospital NHS Foundation Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK.
authors.forename: N A
authors.initials: NA
authors.lastname: Bayman
authors.forename: H
authors.initials: H
authors.lastname: Sheikh
authors.forename: B
authors.initials: B
authors.lastname: Kularatne
authors.forename: P
authors.initials: P
authors.lastname: Lorigan
authors.forename: F
authors.initials: F
authors.lastname: Blackhall
authors.forename: N
authors.initials: N
authors.lastname: Thatcher
authors.forename: C
authors.initials: C
authors.lastname: Faivre-Finn
mesh_terms: D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011829:Radiation Dosage; D055752:Small Cell Lung Carcinoma / Q000473:pathology / Q000532:radiotherapy*; D016896:Treatment Outcome