Platelet gel for the surgical treatment of onychocryptosis.
BACKGROUND
The growth factors derived from platelets contained in platelet-rich plasma comprise a series of molecules that favor the production of collagen with the proliferation of fibroblasts and new blood vessels. These substances exert their effect on the cells, acting in all the stages of cicatrization, especially in hemostasis and early fibroplasia.


METHODS
Thirty-five patients (70 feet) were selected, operated on both sides for ingrown hallux nails, and subjected to two different experimental conditions in a crossover clinical trial with positive control of treatment. Two main variables were analyzed: on one side, the bleeding, according to three preestablished categories, and on the other, the mean time of cicatrization in days.


RESULTS
Significant differences (P < .001) were found between the two groups for bleeding. We observed that cicatrization time did not differ significantly between the two treatments.


CONCLUSIONS
The use of platelet gel for the treatment of onychocryptosis by single nonincisional matricectomy can guarantee good hemostasis, with a significant reduction in bleeding, but does not produce a clinically significant reduction in cicatrization time.
Córdoba-Fernandez
Antonio
A
Department of Podiatry, Seville University, Seville, Spain. acordoba@us.es
Rayo-Rosado
Rafael
R
Juarez-Jiménez
José María
JM
D000328:Adult; D001792:Blood Platelets; D049109:Cell Proliferation; D002921:Cicatrix; D018592:Cross-Over Studies; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005782:Gels; D006133:Growth Substances; D006214:Hallux; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009263:Nails, Ingrown / Q000601:surgery*; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage*; D053657:Platelet-Rich Plasma; D016037:Single-Blind Method
D005782:Gels; D006133:Growth Substances; D010982:Platelet-Derived Growth Factor