[Role of bile in rat gastric mucosal injury due to duodenogastric reflux].
OBJECTIVE
To explore the effect of bile in inducing gastric mucosal injury in rats.


METHODS
SD rats were divided into 4 groups, namely bile duct ligation group, duodenogastric reflux (DGR) group, DGR plus bile duct ligation group and normal control group. The pathological changes in the gastric mucosa and tight junction 3 months after gastrojejunostomy were observed and compared with the findings in the normal control rats.


RESULTS
Compared with the rats in DGR plus bile duct ligation group, the rats in DGR group showed obvious gastric mucosal hyperemia, foveolar hyperplasia and severely impaired tight junction between the gastric mucosal cells.


CONCLUSIONS
Bile plays an important role in gastric mucosal injury due to DGR.
Song
Yin-xue
YX
Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710004, China. songyinxue@126.com
Gong
Jun
J
Wu
Jian-tao
JT
Geng
Juan
J
D000818:Animals; D001646:Bile / Q000502:physiology*; D004383:Duodenogastric Reflux / Q000503:physiopathology*; D017629:Gap Junctions / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley