title: The pathophysiological effects of water and feed restriction in chickens.
abstract: Three-to-five days of water restriction in 5-week-old chickens produced mild dilatation of tubules in distal nephron segments and epithelial necrosis. Most dilated tubules were empty or contained proteinaceous casts. The histopathological changes were more frequent in the left kidney. Combined feed and water restriction decreased the incidence and severity of kidney changes. No histopathological changes were identified in kidneys of feed-restricted chickens. The nephrosis produced by water restriction has features consistent with both prerenal and intrarenal pathophysiological mechanisms. Tubular transport of organic anions was increased by feed and water restriction.
authors.affiliation: Department of Veterinary Pathobiology, Ohio State University, Columbus, Ohio, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Swayne
authors.forename: M J
authors.initials: MJ
authors.lastname: Radin