title: [Role of bile in rat gastric mucosal injury due to duodenogastric reflux].
abstract: OBJECTIVE
  To explore the effect of bile in inducing gastric mucosal injury in rats.
  
  
  METHODS
  SD rats were divided into 4 groups, namely bile duct ligation group, duodenogastric reflux (DGR) group, DGR plus bile duct ligation group and normal control group. The pathological changes in the gastric mucosa and tight junction 3 months after gastrojejunostomy were observed and compared with the findings in the normal control rats.
  
  
  RESULTS
  Compared with the rats in DGR plus bile duct ligation group, the rats in DGR group showed obvious gastric mucosal hyperemia, foveolar hyperplasia and severely impaired tight junction between the gastric mucosal cells.
  
  
  CONCLUSIONS
  Bile plays an important role in gastric mucosal injury due to DGR.
authors.affiliation: Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710004, China. songyinxue@126.com
authors.forename: Yin-xue
authors.initials: YX
authors.lastname: Song
authors.forename: Jun
authors.initials: J
authors.lastname: Gong
authors.forename: Jian-tao
authors.initials: JT
authors.lastname: Wu
authors.forename: Juan
authors.initials: J
authors.lastname: Geng
mesh_terms: D000818:Animals; D001646:Bile / Q000502:physiology*; D004383:Duodenogastric Reflux / Q000503:physiopathology*; D017629:Gap Junctions / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley