title: The effect of high-dose topical corticosteroid therapy on prevention of recurrent nasal polyps after revision endoscopic sinus surgery.
abstract: BACKGROUND
  Topical corticosteroid spray is widely used after endoscopic sinus surgery (ESS) to reduce the recurrence of polyposis. However, it has not always shown satisfactory results in clinical practice. We compared the effects of topical spray and high-dose topical steroid gauze packing on the prevention of recurrent nasal polyps after ESS.
  
  
  METHODS
  We selected 32 patients with recurrent nasal polyps after ESS. In group 1, 18 patients were treated with topical steroid spray and in group 2, 14 patients were treated with triamcinolone acetonide-soaked (40 mg) gauze packing once a week for 2 months after revision ESS. We observed the recurrence of polyps between the two groups for 12 months.
  
  
  RESULTS
  Polyps recurred in 8 of 18 patients in group 1 compared with 1 of 14 patients in group 2 (p = 0.044).
  
  
  CONCLUSIONS
  High-dose topical corticosteroid therapy may be more effective than low-dose topical therapy in preventing recurrent nasal polyps.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Gachon, University Gil Medical Center, Incheon, Korea.
authors.forename: Il Gyu
authors.initials: IG
authors.lastname: Kang
authors.forename: Byung Ki
authors.initials: BK
authors.lastname: Yoon
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Jung
authors.forename: Heung Eog
authors.initials: HE
authors.lastname: Cha
authors.forename: Seon Tae
authors.initials: ST
authors.lastname: Kim
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000188:drug therapy* / Q000601:surgery; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D011182:Postoperative Care / Q000379:methods*; D012189:Retrospective Studies; D055502:Secondary Prevention; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
chemical_list: D005938:Glucocorticoids; D014222:Triamcinolone Acetonide