Pregnancy following gastric bypass for morbid obesity: effect of surgery-to-conception interval on maternal and neonatal outcomes.
BACKGROUND
Conception is discouraged during the period of maximal weight loss following Roux-en-Y gastric bypass (RYGB) because of speculative maternal and fetal concerns. We therefore performed a retrospective cohort study of obstetrical and neonatal outcomes by surgery-to-conception interval.


METHODS
Women with RYGB were stratified into two groups by surgery-to-conception interval of <or=18 or >18 months. Pregnancy and newborn outcomes excluding miscarriages were compared using the chi-square or unpaired t-test for dichotomous and continuous variables, respectively.


RESULTS
Twenty subjects conceived <or=18 months (11.4+/-5.0) and 32 conceived >18 months (47.5+/-41) after RYGB, p< .05. Maternal age, parity, body mass index, and weight gain were similar by group. There were no statistically significant differences in adverse obstetrical outcomes (preterm premature membrane rupture, gestational diabetes, oligohydramnios, intrauterine growth restriction, preterm or post-term delivery) or adverse newborn outcomes (5-min Apgar score <7, intensive care admission, or birth defect).


CONCLUSIONS
Obstetrical and neonatal outcomes are similar in women conceiving during or after the period of maximal weight loss following RYGB.
Wax
Joseph R
JR
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, ME 04102, USA. waxj@mmc.org
Cartin
Angelina
A
Wolff
Renee
R
Lepich
Sharon
S
Pinette
Michael G
MG
Blackstone
Jacquelyn
J
D000328:Adult; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D009767:Obesity, Morbid / Q000601:surgery; D011184:Postoperative Period; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D013997:Time Factors; D015431:Weight Loss