Effect of permethrin plus antioxidants on locomotor activity and striatum in adolescent rats.
Pyrethroids are important insecticides used largely because of their high activity as an insecticide and their low mammalian toxicity. Some studies have demonstrated that these products show neurotoxic effects on the mammalian central nervous system. The aim of the present study was to investigate the propensity of permethrin to induce oxidative stress in adolescent rats and its possible attenuation by Vitamin E alone or+Coenzyme Q(10). Data indicated that adolescent rats exposed to permethrin exhibited alteration in the locomotor activity and plasma membrane fluidity of striatum. Vitamin E+Q(10) and Vitamin E alone supplementation reversed the negative effect on central nervous system. Permethrin alteration of striatum plasma membrane fluidity was restored by Vitamin E+Q(10). Data obtained from red blood cells showed that permethrin did not induce any modification of plasma membrane fluidity in adolescent rats, whereas antioxidants supplementation induced pro-oxidant effect. In summary some differences between antioxidant treatments were observed at striatum level: Coenzyme Q(10)+Vitamin E maintains plasma membrane fluidity, while Vitamin E is more effective to preserve GSH level.
Nasuti
Cinzia
C
Department of Experimental Medicine and Public Health, University of Camerino, Via Madonna delle Carceri, Camerino, Italy. cinzia.nasuti@unicam.it
Falcioni
Maria Letizia
ML
Nwankwo
Innocent Ejike
IE
Cantalamessa
Franco
F
Gabbianelli
Rosita
R
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects*; D020258:Neurotoxicity Syndromes / Q000209:etiology / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects; D026023:Permethrin / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D007306:Insecticides; D014451:Ubiquinone; D014810:Vitamin E; D026023:Permethrin; C024989:coenzyme Q10