title: The effectors responsible for gastrointestinal nematode parasites, Trichinella spiralis, expulsion in rats.
abstract: Helper T (Th2) cells type 2 have a central role in host protective responses to gastrointestinal nematode parasite, Trichinella spiralis infection, but the actual effector mechanisms involved in parasite expulsion are still uncertain. Recent evidences suggest that mast cell recruitment and activation may associate with parasite elimination from host intestines in mice. On the other hand, IgE production may induce defensive responses to primary infection with the helminth in rats. The differences of host effector mechanisms to the same experimental infections might disturb our understanding of the host protective mechanisms to gastrointestinal nematode parasite infection. In order to redefine these differences, we investigated in detail the relationship between intestinal immune responses and worm expulsion following T. spiralis infection among several rat strains including mutants. As a result, there were significant correlations of parasite expulsion with mast cell hyperplasia in addition to serum IgE level. Moreover, mast cell-deficient and dysfunction rats showed delayed worm elimination from their gut. Therefore, the present study suggests that mast cells should also be one of the prominent effector cells involved in T. spiralis parasite expulsion in rats as well as mice.
authors.affiliation: Department of Infectious Diseases, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan. tohrus@hama-med.ac.jp
authors.forename: Tohru
authors.initials: T
authors.lastname: Suzuki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sasaki
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Takagi
authors.forename: Kohji
authors.initials: K
authors.lastname: Sato
authors.forename: Keiji
authors.initials: K
authors.lastname: Ueda
mesh_terms: D000818:Animals; D007073:Immunoglobulin E / Q000097:blood; D007411:Intestinal Diseases, Parasitic / Q000276:immunology* / Q000469:parasitology; D007422:Intestines / Q000276:immunology / Q000469:parasitology; D008407:Mast Cells / Q000276:immunology*; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D013045:Species Specificity; D017160:Trichinella spiralis / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D014235:Trichinellosis / Q000276:immunology* / Q000469:parasitology
chemical_list: D007073:Immunoglobulin E