title: [Hemodynamic factors associated with the development of hypertension].
abstract: Recent studies have focused on the prevention of hypertension among high-risk, nonhypertensive individuals. In this review, we present that the deficiency of renal sodium excretion, small artery remodeling, and arterial stiffening might be potent mechanisms underlying the development of hypertension. The changes of these hemodynamic factors cause to increase blood pressure, and increasing blood pressure would accelerate those changes again. To break the vicious circle, not only the management of risk factors such as diabetes, obesity, or smoking, but also the intervention with antihypertensive agents is considered as a useful and effective procedure.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Shimizu
authors.forename: Kazuomi
authors.initials: K
authors.lastname: Kario
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D003920:Diabetes Mellitus; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D007668:Kidney / Q000378:metabolism; D009765:Obesity; D012306:Risk; D012307:Risk Factors; D012907:Smoking; D012964:Sodium / Q000378:metabolism
chemical_list: D000959:Antihypertensive Agents; D012964:Sodium