title: Subgingival triclosan-polydimethylsiloxane gel as an adjunct to scaling and root planing.
abstract: OBJECTIVE
  To evaluate the influence of a triclosan-polydimethylsiloxane-containing gel when used as an adjunct to scaling and root planing on the treatment of chronic periodontal disease.
  
  
  METHODS
  A 3-month, double-blind, randomized parallel design clinical trial was performed in 20 subjects with chronic periodontitis. The subjects, presenting at least three anterior sites with probing depth (PD) +/- 5 mm and bleeding on probing (BoP), were randomly assigned to two experimental groups: Group SRP-T: scaling/root planing plus test gel application (triclosan 1% + polydimethylsiloxane 13%) or Group SRP: scaling/root planing plus control gel application (polydimethylsiloxane 13%). Immediately following mechanical therapy, each assigned gel was applied to the selected sites and once a week during the following 3 weeks. Re-examinations were carried out on days 45 and 90 after the last irrigation.
  
  
  RESULTS
  Significant reductions in PD and clinical attachment level (CAL) were observed for both groups in both periods (P < 0.05). However, SRP-T showed lower means of PD than SRP at Day 45 (3.60 +/- 0.87 versus 4.77 +/- 1.38, respectively, P = 0.035) and CAL at both 45 days (4.63 +/- 1.17 versus 6.07 +/- 1.43, P = 0.023) and 90 days (4.45 +/- 1.19 versus 5.91 +/- 1.37, P = 0.021). No differences were found for bleeding on probing, plaque index and gingival recession (P > 0.05) between groups.
authors.affiliation: Department of Periodontology, School of Dentistry, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Giovana
authors.initials: G
authors.lastname: Lecio
authors.forename: Luciana M
authors.initials: LM
authors.lastname: Shaddox
authors.forename: Marcelo
authors.initials: M
authors.lastname: Diniz Carvalho
authors.forename: Poliana Mendes
authors.initials: PM
authors.lastname: Duarte
authors.forename: Roberto
authors.initials: R
authors.lastname: Santos Tunes
authors.forename: Getulio Rocha
authors.initials: GR
authors.lastname: Nogueira-Filho
authors.forename: Enilson Antonio
authors.initials: EA
authors.lastname: Sallum
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003774:Dental Plaque Index; D012534:Dental Scaling; D004129:Dimethylpolysiloxanes / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000188:drug therapy / Q000628:therapy; D005889:Gingival Recession / Q000188:drug therapy / Q000628:therapy; D006801:Humans; D008297:Male; D017622:Periodontal Attachment Loss / Q000188:drug therapy / Q000628:therapy; D010514:Periodontal Pocket / Q000188:drug therapy / Q000628:therapy; D010518:Periodontitis / Q000188:drug therapy / Q000628:therapy*; D016745:Root Planing; D014260:Triclosan / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D004129:Dimethylpolysiloxanes; D014260:Triclosan; C013830:baysilon