Phenytoin induced severe disabling osteomalacia in a young male with seizure disorder.
While the use of anti epileptic drugs (AEDs) for a long period is a known risk factor for bone loss and pathological fractures, yet the physicians are not yet sensitized to this possibility. It is now believed that the patients who have fractures due to long-term treatment with anticonvulsants have osteomalacia as the predominant lesion. This has been attributed to the alterations in the levels of circulating calcium and calcitropic hormones. Here we report a case of a young male who had been on anticonvulsants for 11 years and was admitted with us with severe bone pains, multiple pathological pseudo fractures and a severe degree of disability secondary to phenytoin induced osteomalacia.
Khaira
Ambar
A
Department of Medicine, University College of Medical Sciences and GT B Hospital, Delhi 110095.
Gupta
Ankur
A
Madhu
S V
SV
Khaira
Deepa Dash
DD
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D004185:Disability Evaluation; D004660:Encephalitis / Q000150:complications; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy*; D006801:Humans; D007194:India; D008134:Long-Term Care; D008297:Male; D010018:Osteomalacia / Q000139:chemically induced* / Q000175:diagnosis; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use
D000927:Anticonvulsants; D010672:Phenytoin