title: Molecular imprinting in sol-gel matrix.
abstract: Molecular imprinting is a newly developed methodology which provides molecular assemblies of desired structures and properties and is being increasingly used for several applications such as in separation processes, microreactors, immunoassays and antibody mimics, catalysis, artificial enzymes, biosensor recognition elements and bio- and chemo-sensors. The ambient processing conditions and versatility of the sol-gel process makes sol-gel glassy matrix suitable for molecular imprinting. The progress of sol-gel based molecular imprinted polymers (MIPs) for various applications can be seen from the growing number of publications. The main focus of the review is molecular imprinting in sol-gel matrix and applications of molecular imprinted sol-gel derived materials for the development of sensors. Combining sol-gel process with molecular imprinting enables to procure the sensors with greater sensitivity and selectivity necessary for sensing applications. The merits, problems, challenges and factors affecting molecular imprinting in sol-gel matrix have been discussed. Considerable attention has been drawn on recent developments like use of organically modified silane precursors (ORMOSILS) for the synthesis of hybrid molecular imprinted polymers (HMIPs) and applying surface sol-gel process for molecular imprinting. The development of molecular imprinted sol-gel nanotubes for biochemical separation and bio-imprinting is a new advancement and is under progress. Templated xerogels and molecularly imprinted sol-gel films provide a good platform for various sensor applications.
authors.affiliation: Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, 208016-Kanpur, India.
authors.forename: Radha
authors.initials: R
authors.lastname: Gupta
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
mesh_terms: D001704:Biopolymers / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods*; D001709:Biotechnology / Q000379:methods; D005782:Gels; D054802:Molecular Imprinting / Q000379:methods*; D012997:Solvents
chemical_list: D001704:Biopolymers; D005782:Gels; D012997:Solvents