Reduced interleukin-5 production by peripheral CD4+ T cells in common variable immunodeficiency patients.
We evaluated the capacity of peripheral CD4+ T helper cells in four Common Variable Immunodeficiency (CVI) patients to secrete interleukin-4 (IL-4) and IL-5. While in control CD4+ T cells, stimulated via CD3 and cultured in presence of IL-2 or IL-15, a 10 fold increased production of IL-5 (146 +/- 30; 142 +/- 25 pg/ml) was found, a 4 fold increment of this cytokine was, instead, detected in 3 out of 4 CVI patients (34 +/- 13; 39 +/- 12 pg/ml) (p < 0.05). In conclusion, the reduction of IL-5, involved in the late regulation of B cell differentiation into Ig-secreting plasma cells, may contribute to the defective antibody production in CVI patients.
Del Vecchio
Giovanni Carlo
GC
Department of Biomedicine of the Development Age, University of Bari, Bari, Italy.
Martire
Baldassarre
B
Lassandro
Giuseppe
G
Cecinati
Valerio
V
De Mattia
Delia
D
Ciccarelli
Maria
M
Piacente
Laura
L
Giordano
Paola
P
D000293:Adolescent; D000328:Adult; D000921:Antibody-Producing Cells / Q000378:metabolism / Q000473:pathology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D002478:Cells, Cultured; D002648:Child; D017074:Common Variable Immunodeficiency / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D015536:Down-Regulation / Q000276:immunology*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis / Q000172:deficiency; D015848:Interleukin-5 / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D008297:Male; D010950:Plasma Cells / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
C508599:IL5 protein, human; D007136:Immunoglobulins; D015848:Interleukin-5