Dynamic and structural properties of the skeleton in hypoparathyroidism.
Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of the skeleton in hypoparathyroidism. Thirty-three subjects with hypoparathyroidism and 33 age- and sex-matched control subjects with no known metabolic diseases underwent percutaneous iliac crest bone biopsies after double-labeling with tetracycline. The main outcome was histomorphometric assessment of structural and dynamic skeletal parameters. Subjects with hypoparathyroidism had greater cancellous bone volume (mean +/- SD; BV/TV: 23.5 +/- 8 versus 19.7 +/- 5%, p = 0.02), trabecular width (Tb.Wi: 136.1 +/- 37 versus 119.3 +/- 21 microm, p = 0.03), and cortical width (Ct.Wi: 923.4 +/- 420 versus 753.5 +/- 246 microm, p = 0.05) than control subjects. Dynamic skeletal indices, including mineralizing surface (MS: 0.85 +/- 1.58 versus 4.27 +/- 3.32%, p < 0.0001) and bone formation rate (BFR/BS: 0.006 +/- 0.014 versus 0.032 +/- 0.028 microm(3)/microm(2)/d, p < 0.0001), were profoundly suppressed in the hypoparathyroid subjects. We conclude that hypoparathyroidism is characterized by markedly unusual structural and dynamic properties of bone.
Rubin
Mishaela R
MR
College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Dempster
David W
DW
Zhou
Hua
H
Shane
Elizabeth
E
Nickolas
Thomas
T
Sliney
James
J
Silverberg
Shonni J
SJ
Bilezikian
John P
JP
D000328:Adult; D000818:Animals; D001706:Biopsy; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D015331:Cohort Studies; D003720:Densitometry / Q000379:methods; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause