Controlling cell length.
Control of cell dimensions is an important but poorly understood aspect of morphogenesis. In this review, our primary focus is on control of cell length in different types of cells and cytoskeletal regulation of this parameter. Cell length is not a constant characteristic of certain cell type but of cells of fibroblastic morphology. Since cytoskeleton organization can change during different processes of morphogenesis changes in length control during cell spreading, epithelio-mesenchymal transformation and also in neoplastic transformation are discussed.
Kharitonova
Margarita A
MA
Institute of Carcinogenesis, Cancer Research Center of Russian Federation, Kashirskoye shosse 24, 115478 Moscow, Russian Federation. ritasarc@mail.ru
Vasiliev
Jury M
JM
D000818:Animals; D048430:Cell Shape; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000378:metabolism*; D005347:Fibroblasts / Q000166:cytology*; D009024:Morphogenesis