title: Insulin glargine has a long duration of effect following administration either once daily or twice daily in divided doses in healthy cats.
abstract: The pharmacological effects of glargine administered once or twice daily were compared in six healthy cats. A two-way crossover study was performed with insulin and glucose concentrations measured following subcutaneous administration of glargine once daily (0.5 U/kg) or twice daily (0.25 U/kg, repeated after 12h). Nadir glucose concentration and mean daily glucose concentration did not differ significantly following insulin administration once daily or twice daily in divided doses. Time to reach last glucose nadir differed, with longer intervals occurring following twice daily dosing. Blood glucose failed to return to baseline concentration by 24h in three of six cats in each treatment group. Insulin variables were not significantly different following once or twice daily dosing. This study in healthy cats demonstrates that glargine has a long duration of action with carry-over effects to the next day likely, regardless of dosing regimen. A study in diabetic cats is required to determine the best dosing regimen.
authors.affiliation: Centre for Companion Animal Health, School of Veterinary Science, The University of Queensland, 4072 Brisbane, Australia.
authors.forename: Rhett D
authors.initials: RD
authors.lastname: Marshall
authors.forename: Jacquie S
authors.initials: JS
authors.lastname: Rand
authors.forename: John M
authors.initials: JM
authors.lastname: Morton
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D002415:Cats / Q000097:blood* / Q000378:metabolism; D018592:Cross-Over Studies; D004334:Drug Administration Schedule / Q000662:veterinary; D005260:Female; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007279:Injections, Subcutaneous / Q000662:veterinary; D007328:Insulin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000069036:Insulin Glargine; D049528:Insulin, Long-Acting; D008297:Male; D011897:Random Allocation; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D049528:Insulin, Long-Acting; D000069036:Insulin Glargine