title: Synthesis and characterization of some new bishydrazones derived from isatin.
abstract: The scientific literature states that isatin and its derivatives exhibit antibacterial, antifungal, anticonvulsant, cytotoxic and anti-HIV activities. The aim of our study was to enlarge the number of isatin derivatives.
  
  
  METHODS
  We synthesized some new hydrazones and then, the corresponding bishydrazones using salicylaldehyde. By condensing isatin and its derivatives (methyl-, nitro-, brom-) with hydrazine, corresponding hydrazones were obtained. The bishydrazones were synthesized by refluxing the obtained hydrazones with salicylaldehyde in methanolic solution. The structure of new compounds was confirmed by elemental and spectral analysis. The lipophilicity of the synthesized derivatives was expressed by clog P values. The antibacterial and antifungal activities of the compounds were determined using disk-diffusion method against Gram positive, Gram negative bacteria, and Candida albicans.
  
  
  RESULTS
  New bishydrazines derived from isatin have been synthesized; their structures have been confirmed by elemental and spectral analysis.
authors.affiliation: Gr.T.Popa University of Medicine and Pharmacy Iaşi, School of Pharmacy.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Tătărîngă
authors.forename: Olivia
authors.initials: O
authors.lastname: Dorneanu
authors.forename: Eugenia
authors.initials: E
authors.lastname: Stefănescu
authors.forename: Maria
authors.initials: M
authors.lastname: Dorneanu
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology*; D007510:Isatin / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D008826:Microbial Sensitivity Tests; D013054:Spectrophotometry, Atomic
chemical_list: D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006835:Hydrazones; C013243:salicylaldehyde; D007510:Isatin