The Na-K-ATPase and calcium-signaling microdomains.
The Na-K-ATPase is an energy-transducing ion pump that converts the free energy of ATP into transmembrane ion gradients. It also serves as a functional receptor for cardiotonic steroids such as ouabain and digoxin. Binding of ouabain to the Na-K-ATPase can activate calcium signaling in a cell-specific manner. The exquisite calcium modulation via the Na-K-ATPase is achieved by the ability of the pump to integrate signals from numerous protein and non-protein molecules, including ion transporters, channels, protein kinases/phosphatases, as well as cellular Na+. This review focuses on the unique properties of the Na-K-ATPase and its role in the formation of different calcium-signaling microdomains.
Tian
Jiang
J
Department of Physiology and Pharmacology, University of Toledo Health Science Campus, Toledo, Ohio, USA.
Xie
Zi-jian
ZJ
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D002451:Cell Compartmentation / Q000502:physiology*; D004847:Epithelial Cells / Q000201:enzymology*; D006801:Humans; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D000254:Sodium-Potassium-Exchanging ATPase