title: Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis.
abstract: Metronidazole, which is used for the treatment of infections caused by anaerobic organisms, was evaluated in Mycobacterium tuberculosis-infected guinea pigs. M. tuberculosis can adapt to hypoxia, which is present in the primary lesions of infected guinea pigs. Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation.
authors.affiliation: Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.
authors.forename: Donald R
authors.initials: DR
authors.lastname: Hoff
authors.forename: Megan L
authors.initials: ML
authors.lastname: Caraway
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Brooks
authors.forename: Emily R
authors.initials: ER
authors.lastname: Driver
authors.forename: Gavin J
authors.initials: GJ
authors.lastname: Ryan
authors.forename: Charles A
authors.initials: CA
authors.lastname: Peloquin
authors.forename: Ian M
authors.initials: IM
authors.lastname: Orme
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Basaraba
authors.forename: Anne J
authors.initials: AJ
authors.lastname: Lenaerts
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D005260:Female; D006168:Guinea Pigs; D007538:Isoniazid / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D008795:Metronidazole / Q000494:pharmacology*; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification; D011718:Pyrazinamide / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
chemical_list: D000995:Antitubercular Agents; D008795:Metronidazole; D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin