A longitudinal study of comparison of the Kato-Katz technique and indirect hemagglutination assay (IHA) for the detection of schistosomiasis japonica in China, 2001-2006.
From 2001 to 2006, about one-third of the residents aged 5-65 years were selected as the subjects in a schistosome-endemic village located in Jiangxi Province, China. Every 1 year, all participants were analyzed by the Kato-Katz parasitologic examination and indirect hemagglutination assay (IHA). Statistical analysis of the results showed the k indices ranged from 0.250 to 0.347 between the two methods. Assuming the Kato-Katz results as the gold standard reference, the specificity of the IHA was from 60% to 77%, the positive predictive value of this method was from 19% to 30%, and its sensitivity and negative predictive value were more than 97%. The IHA method is unsuitable for individual screening in endemic community with relatively high prevalence (e.g. with >10% or more prevalence). A search for a better diagnostic test that can be applied in field situations in China is essential and should be given high priority.
Zhou
Yi-Biao
YB
Department of Epidemiology, School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China. z yibiao@hotmail.com
Yang
Mei-Xia
MX
Tao
Po
P
Jiang
Qiu-Lin
QL
Zhao
Gen-Ming
GM
Wei
Jian-Guo
JG
Jiang
Qing-Wu
QW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D006386:Hemagglutination Tests / Q000379:methods; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D010274:Parasitology / Q000379:methods; D011237:Predictive Value of Tests; D012549:Schistosoma japonicum / Q000302:isolation & purification*; D012554:Schistosomiasis japonica / Q000175:diagnosis* / Q000453:epidemiology; D012680:Sensitivity and Specificity