Cyclin and protamine as prognostic molecular marker for testicular sperm extraction in patients with azoospermia.
The CCNA1, CCNB1, CCNB2, PRM1, and PRM2 messenger RNA transcript ratios were significantly decreased in patients with spermatogenic disorders. These messenger RNA transcript ratios in patients with successful sperm retrieval were higher than in patients with failed sperm retrieval.
Haraguchi
Takahiro
T
Department of Organs Therapeutics, Division of Urology, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Ishikawa
Tomomoto
T
Yamaguchi
Kohei
K
Fujisawa
Masato
M
D053713:Azoospermia / Q000175:diagnosis / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D019925:Cyclin A / Q000378:metabolism; D056750:Cyclin A1; D019926:Cyclin B / Q000378:metabolism; D056744:Cyclin B1; D056765:Cyclin B2; D016213:Cyclins / Q000378:metabolism*; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000378:metabolism; D008297:Male; D011379:Prognosis; D011479:Protamines / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D053625:Sperm Retrieval; D013737:Testis / Q000473:pathology
D015415:Biomarkers; C503745:CCNA1 protein, human; C534699:CCNB1 protein, human; C503758:CCNB2 protein, human; D019925:Cyclin A; D056750:Cyclin A1; D019926:Cyclin B; D056744:Cyclin B1; D056765:Cyclin B2; D016213:Cyclins; C082073:PRM1 protein, human; D011479:Protamines; D012333:RNA, Messenger; C068621:protamine 2