Smoking status as a potential confound in the BOLD response of patients with schizophrenia.
BACKGROUND
Functional magnetic resonance imaging (FMRI) studies comparing schizophrenia patients and controls may have been confounded by the vascular effects of heavier long-term cigarette use in patients.


METHODS
The blood oxygen level dependent (BOLD) response to a simple sensorimotor task was compared between schizophrenia patient with a smoking history (mean 17 pack years) and carefully matched patient non-smokers and control non-smokers.


RESULTS
Group differences in activation magnitude and spatial extent were non-significant.


CONCLUSIONS
Typical smoking histories in schizophrenia patients do not significantly confound FMRI results in simple sensorimotor tasks when patient demographics are carefully controlled.
Leyba
Leonard
L
The Mind Research Network, Pete & Nancy Domenici Hall, 1101 Yale Blvd. NE, Albuquerque, NM 87131, United States. lleyba@salud.unm.edu
Mayer
Andrew R
AR
Gollub
Randy L
RL
Andreasen
Nancy C
NC
Clark
Vincent P
VP
D000328:Adult; D001921:Brain / Q000098:blood supply*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D015995:Prevalence; D011596:Psychomotor Disorders / Q000175:diagnosis / Q000453:epidemiology; D012559:Schizophrenia / Q000453:epidemiology*; D012907:Smoking / Q000453:epidemiology*; D055815:Young Adult
D010100:Oxygen