Absolute stereochemistry of amphidinolide Q.
The absolute configurations at five chiral centers in amphidinolide Q (1), a cytotoxic 12-membered macrolide isolated from a marine dinoflagellate Amphidinium sp., were elucidated to be 4R, 7R, 9S, 11R, and 13R on the basis of NMR analyses and a modified Mosher's method.
Takahashi
Yohei
Y
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Kubota
Takaaki
T
Fukushi
Eri
E
Kawabata
Jun
J
Kobayashi
Jun'ichi
J
D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry; D018942:Macrolides / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D013237:Stereoisomerism; D000097442:Amphidinolides
D018942:Macrolides; C532855:amphidinolide Q; D000097442:Amphidinolides