title: [Adult onset Still's disease].
abstract: Adult onset Still's disease is a rare, febrile, multisystem rheumatic disease with unknown etiology, which runs an intermittent course and can either go into remission after months to years or progress to a chronic course with substantial joint destruction. The prevalence of this disease has been increasing in the last decade presumably caused by better diagnostic tools but also by a higher awareness among physicians taking care of patients with "fever of unknown origin". This review is intended to augment this trend, since research on the role of proinflammatory cytokines in this disease has led to an improved diagnostic and therapeutic repertoire over the last few years. Ferritin and interleukin-18 serum levels are valuable diagnostic parameters and blockade of interleukin-1, interleukin-6, and tumor-necrosis-factor alpha can effectively control the inflammatory activity of this disease in most cases and also in life-threatening conditions.
authors.affiliation: Medizinische Klinik III, Klinikum der Friedrich-Alexander-Universität, Krankenhausstr. 12, 91054, Erlangen, Deutschland. bernhard.manger@uk-erlangen.de
authors.forename: B
authors.initials: B
authors.lastname: Manger
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use; D002908:Chronic Disease; D016207:Cytokines / Q000097:blood; D003937:Diagnosis, Differential; D005335:Fever of Unknown Origin / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D011379:Prognosis; D016706:Still's Disease, Adult-Onset / Q000145:classification / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology
chemical_list: D018501:Antirheumatic Agents; D016207:Cytokines; D007166:Immunosuppressive Agents