The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation.
A cassette of cytoplasmic Drosophila tumor suppressors, including the kinases Hippo and Warts, has recently been linked to the transmembrane tumor suppressor Fat. These proteins act within interconnected signaling pathways, the principal functions of which are to control the growth and polarity of developing tissues. Recent studies have enhanced our understanding of the basis for signal transduction by Fat and Warts pathways, including the identification of a DNA-binding protein at the end of the pathway, have established the conservation of Fat and Warts signaling from flies to mammals, and have given us new insights into their regulation and biological functions.
Reddy
B V V G
BV
Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA.
Irvine
Kenneth D
KD
D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D017124:Conserved Sequence; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000201:enzymology; D008322:Mammals / Q000378:metabolism; D009369:Neoplasms / Q000201:enzymology; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction
D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; C472307:ft protein, Drosophila; D011494:Protein Kinases; C093503:wts protein, Drosophila