MS07116 sodium selenosulfate synthesis and demonstration of its in vitro cytotoxic activity against HepG2, Caco2, and three kinds of leukemia cells.
The biological profile of sodium selenosulfate, Na(2)SeSO(3), is still largely unknown. The present study found that sodium sulfite reacted with elemental selenium at nanoparticle size already at 37 degrees C to yield sodium selenosulfate. Additionally, selenosulfate was obtained by mixing sodium selenite, glutathione, and sodium sulfite at room temperature. In vitro, sodium selenosulfate killed HepG2 or Caco2 cells, in a dose-dependent fashion, and 12.5 microM fully suppressed their proliferation. In addition, sodium selenosulfate showed a consistent cytotoxic effect when added to three kinds of leukemia cell lines (HL60, T lymph adenoma, and Daudi).
Zhang
Jinsong
J
School of Chemistry and Material Science, University of Science and Technology of China, Anhui, People's Republic of China. zjszyzzc@mail.hf.ah.cn
Lu
Hongjuan
H
Wang
Xufang
X
D000818:Animals; D045744:Cell Line, Tumor / Q000187:drug effects*; D003603:Cytotoxins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D053938:DNA Fragmentation; D006801:Humans; D007938:Leukemia; D015394:Molecular Structure; D010316:Particle Size; D012643:Selenium / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D018036:Selenium Compounds / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D013431:Sulfates / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*
D003603:Cytotoxins; D018036:Selenium Compounds; D013431:Sulfates; D012643:Selenium; C519925:sodium selenosulfate