title: A distributed lag model with first order auto-regressive error term for hemoglobin response to erythropoietin in dialysis patients.
abstract: There is an urgent need to devise an erythropoietin dosing protocol which can help regulate hemoglobin levels within the range recommended by the Kidney Disease Outcomes Quality Initiative(KDOQI). The objective of this analysis was to mathematically model the dose response relationship between Hemoglobin(Hb) and Erythropoietin(EPO). Such a model may be used to predict a patient's EPO requirements and guide dosing accordingly. A dynamic regression model with a distributed lag structure was used with good results.
authors.affiliation: Michigan State University, East Lansing, MI, USA.
authors.forename: Ashwani K
authors.initials: AK
authors.lastname: Gupta
authors.forename: Anatole
authors.initials: A
authors.lastname: Besarab
mesh_terms: D004305:Dose-Response Relationship, Drug; D004921:Erythropoietin / Q000008:administration & dosage*; D006454:Hemoglobins / Q000187:drug effects*; D006801:Humans; D008954:Models, Biological; D012044:Regression Analysis; D006435:Renal Dialysis
chemical_list: D006454:Hemoglobins; D004921:Erythropoietin