title: Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics.
abstract: Mutation of the cj1461 predicted methyltransferase gene reduced the motility of Campylobacter jejuni 81-176. Electron microscopy revealed that the mutant strain had flagella but with aberrant structure. The Deltacj1461 mutant was sevenfold more adherent to but 50-fold less invasive of INT-407 human epithelial cells than the wild type.
authors.affiliation: Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA.
authors.forename: Joo-Sung
authors.initials: JS
authors.lastname: Kim
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Li
authors.forename: If H A
authors.initials: IH
authors.lastname: Barnes
authors.forename: David A
authors.initials: DA
authors.lastname: Baltzegar
authors.forename: Mohanasundari
authors.initials: M
authors.lastname: Pajaniappan
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Cullen
authors.forename: M Stephen
authors.initials: MS
authors.lastname: Trent
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Burns
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Thompson
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D016123:Campylobacter jejuni / Q000201:enzymology* / Q000235:genetics / Q000472:pathogenicity; D002460:Cell Line; D015254:DNA Modification Methylases / Q000235:genetics / Q000378:metabolism*; D005407:Flagella / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D005816:Genetic Complementation Test; D006801:Humans; D046529:Microscopy, Electron, Transmission; D008957:Models, Genetic; D009154:Mutation; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D015254:DNA Modification Methylases