Ground-glass opacities showing an adenoma-to-carcinoma sequence in the lung.
We encountered a patient with three left lower lobe pulmonary tumors evident as discrete ground-glass opacities by computed tomography. Pathological diagnoses of the resected lesions included a focus of atypical adenomatous hyperplasia (AAH) and two localized noninvasive bronchioloalveolar carcinomas (BACs) of types A and C according to Noguchi's classification. This case supports the hypothesis of an adenoma-to-carcinoma sequence in the lung, as the coexisting lesions represented sequential adenocarcinoma progression from a precancerous lesion, AAH, to very early-stage adenocarcinoma, noninvasive BAC.
Nakamura
Haruhiko
H
Department of Chest Surgery, 13-1 Higashikaigan-cho, Atami Shizuoka 413-0012, Japan. h.nakamura@iuhw.ac.jp
Hirata
Takeshi
T
Taguchi
Masahiko
M
Kitamura
Hajime
H
D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000000981:diagnostic imaging / Q000473:pathology*; D000236:Adenoma / Q000000981:diagnostic imaging / Q000473:pathology; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging / Q000473:pathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D011230:Precancerous Conditions / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed