Current antioxidant molecular therapies for oxidative stress-related ailments.
Oxidative cell damage is a natural occurring phenomenon due to the aerobic conditions where cells are embedded; however, such injury can efficiently be controlled and repaired by the inherent antioxidants of the cell. When the oxidant/antioxidant balance is disrupted towards the former by any chemical, biological or physical insult a pathological state could be developed, therefore, an extensive list of compounds with proved or assumed antioxidants properties has largely been used for improving or restoring the health status. Pharmacological therapies as well as dietary or complementary therapies are continuously being investigated for the counteracting of the harmful or damaging effects of oxidation in cells or tissues. However, critical antioxidant levels are not always achieved at the target damaged cells by these approaches; on the other side, the expression of recombinant antioxidant genes specifically directed to the afflicted cell by gene delivery has shown remarkable results. In this review we summarize the literature focused on some of the current antioxidant molecular pharmacological strategies with particular emphasis to the gene transfer protocols involved in the treatment of oxidative stress-related disorders.
Ramos-Márquez
Martha E
ME
Instituto de Enfermedades Crónico Degeneratives, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara. Guadalajara, Jal., Mexico.
Siller-López
Fernando
F
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy*; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species; D015427:Reperfusion Injury / Q000188:drug therapy*
D000975:Antioxidants; D017382:Reactive Oxygen Species