title: Proton magnetic resonance spectroscopy and biochemical investigation of type 2 diabetes mellitus in Asian Indians: observation of high muscle lipids and C-reactive protein levels.
abstract: We report the determination of intramyocellular lipids (IMCLs) of the soleus muscle of patients with type 2 diabetes mellitus (T2DM) using proton magnetic resonance spectroscopy. In addition, the various anthropometric and biochemical profiles of these patients were determined, including estimation of C-reactive protein (CRP), an inflammatory marker of coronary heart disease, and insulin resistance [Homeostasis Model Assessment (HOMA-IR)]. The estimated CRP level and the IMCL content in these patients were correlated with body mass index, percentage of body fat, other measures of abdominal obesity, serum lipoproteins, fasting and post-oral glucose load serum insulin levels and other surrogate markers of insulin resistance. The IMCL content (P=.04), CRP (P=.008) and insulin resistance (P=.0007) were significantly higher in T2DM patients compared to healthy controls. However, IMCL content did not correlate with values of fasting insulin, HOMA-IR or CRP in either group. These findings have strong implications of increased cardiovascular risk in Asian Indians with T2DM. The absence of relationship between CRP and IMCL needs to be explored further in a study using a large sample size.
authors.affiliation: Department of Medicine, All India Institute of Medical Sciences, New Delhi-110 029, India.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Sinha
authors.forename: Anoop
authors.initials: A
authors.lastname: Misra
authors.forename: Manish
authors.initials: M
authors.lastname: Rathi
authors.forename: Virendra
authors.initials: V
authors.lastname: Kumar
authors.forename: Ravindra M
authors.initials: RM
authors.lastname: Pandey
authors.forename: Kalpana
authors.initials: K
authors.lastname: Luthra
authors.forename: Naranamangalam R
authors.initials: NR
authors.lastname: Jagannathan
mesh_terms: D000328:Adult; D044466:Asian People; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007194:India; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D016014:Linear Models; D050356:Lipid Metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D011522:Protons; D018709:Statistics, Nonparametric
chemical_list: D007328:Insulin; D011522:Protons; D002097:C-Reactive Protein