Scaffold-hopping cascade yields potent inhibitors of 5-lipoxygenase.
Hofmann
Bettina
B
Institute of Organic Chemistry and Chemical Biology, ZAFES/CMP, Johann Wolfgang Goethe-University, Siesmayerstr. 70, 60323 Frankfurt am Main, Germany.
Franke
Lutz
L
Proschak
Ewgenij
E
Tanrikulu
Yusuf
Y
Schneider
Petra
P
Steinhilber
Dieter
D
Schneider
Gisbert
G
D018927:Anti-Asthmatic Agents / Q000737:chemistry* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D002478:Cells, Cultured; D015195:Drug Design; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D007093:Imidazoles; D016859:Lipoxygenase Inhibitors