Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study).
We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7%). The independent factors which specified cardiovascular events were age (hazard ratio (HR)=1.13; 95% confidence interval (CI): 1.10-1.16; p<0.0001) and sex (HR=2.18; 95%CI: 1.23-3.85; p=0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR=1.11; 95%CI: 0.61-2.02; p=0.731).
Tamaki
Shinji
S
Division of Cardiology, Department of Medicine, Kohka Public Hospital, Rokushin, Kohka-City, Shiga, Japan. shitamaki-circ@umin.ac.jp
Nakamura
Yasuyuki
Y
Tabara
Yasuharu
Y
Okamura
Tomonori
T
Kanda
Hideyuki
H
Kita
Yoshikuni
Y
Kadowaki
Takashi
T
Tsujita
Yasuyuki
Y
Chowdhury Turin
Tanvir
T
Horie
Minoru
M
Miki
Tetsuro
T
Ueshima
Hirotsugu
H
D044466:Asian People / Q000706:statistics & numerical data*; D002318:Cardiovascular Diseases / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*
C544065:AGTR1 protein, human; D044140:Receptor, Angiotensin, Type 1