title: Wall shear rate in supra-aortic vessels: a factor for different atherosclerotic pattern?
abstract: BACKGROUND
  Atherosclerotic lesions of the upper extremity arise three to five times more often at the origin of the left subclavian artery than on the right side. The aim of this study was to investigate, whether the hemodynamic forces (peak wall shear rate) in the large supra-aortic branches measured by MRI differ in healthy subjects.
  
  
  METHODS
  Peak wall shear rate (WSR) and blood flow was assessed in the left carotid, left subclavian and innominate artery in ten healthy volunteers (5 females, mean age of 35.2 +/- 9 years) using high resolution (pixel size 0.6 mm 2) magnetic resonance imaging (MRI) flow velocity measurements.
  
  
  RESULTS
  There is no difference between the maximum WSR of the three large supra-aortic vessels. Only within the proximal (327 +/- 132s-1) and distal wall (458 +/- 154s-1) of the innominate artery a significant difference (p = 0.011) of the WSR was found.
  
  
  CONCLUSIONS
  The results from this study indicate that WSR is not different in the supra-aortic vessels. Therefore the atherosclerotic pattern in the subclavian and innominate arteries may not be explained by differences in these hemodynamic forces.
authors.affiliation: Clinic of Angiology, Department of Medicine, University Hospital Zurich, Switzerland. roger.simon@usz.ch
authors.forename: R W
authors.initials: RW
authors.lastname: Simon
authors.forename: S
authors.initials: S
authors.lastname: Spring
authors.forename: R
authors.initials: R
authors.lastname: Luechinger
authors.forename: P
authors.initials: P
authors.lastname: Boesiger
authors.forename: B R
authors.initials: BR
authors.lastname: Amann-Vesti
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000503:physiopathology*; D001783:Blood Flow Velocity; D016122:Brachiocephalic Trunk / Q000502:physiology*; D002339:Carotid Arteries / Q000502:physiology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D012039:Regional Blood Flow; D013314:Stress, Mechanical; D013348:Subclavian Artery / Q000502:physiology*