Recent advances in the genetics of diabetes.
After many years of effort with only modest result, the last 5 years has seen a tremendous surge in our understanding of the genetics of diabetes. This review will focus on the therapeutic implications of diagnosing monogenic diabetes and the recent advances in type 1 and type 2 diabetes genetics following the development of Genome Wide Association studies.
Pearson
Ewan R
ER
Division of Medicine & Therapeutics, Ninewells Hospital & Medical School, Dundee DD19SY, United Kingdom. e.pearson@chs.dundee.ac.uk
D001786:Blood Glucose; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D024661:Potassium Channels, Inwardly Rectifying / Q000378:metabolism; D000099161:Kcnj11 Channel
D001786:Blood Glucose; D051538:Hepatocyte Nuclear Factor 1-alpha; D007004:Hypoglycemic Agents; D024661:Potassium Channels, Inwardly Rectifying; D000099161:Kcnj11 Channel; C496487:HNF1A protein, human