title: A live attenuated turkey rhinotracheitis virus vaccine. 2. The use of the attenuated strain as an experimental vaccine.
abstract: An attenuated turkey rhinotracheitis (TRT) vaccine strain, when given either by eye drop or by aerosol, has been shown to be effective in protecting 1- to 11-day-old turkey poults against an experimental challenge with TRTV up to 14 weeks later. TRT antibody-free poults and poults hatched from TRT-immune dams were both equally well protected, although a high proportion of the latter did not respond serologically to the vaccine. As little as 1 CD50 of vaccine was found to be effective in protecting poults against challenge. Immunity developed within about 6 days of vaccination of 7-day-old TRT antibody-free poults and humoral antibody persisted for at least 14 weeks after a single vaccination at 4 weeks of age.
authors.affiliation: AFRC Institute for Animal Health, Houghton Laboratory, Houghton, Huntingdon, Cambridgeshire, England.
authors.forename: J K
authors.initials: JK
authors.lastname: Cook
authors.forename: H C
authors.initials: HC
authors.lastname: Holmes
authors.forename: P M
authors.initials: PM
authors.lastname: Finney
authors.forename: C A
authors.initials: CA
authors.lastname: Dolby
authors.forename: M M
authors.initials: MM
authors.lastname: Ellis
authors.forename: M B
authors.initials: MB
authors.lastname: Huggins