Role of tissue factor disulfides and lipid rafts in signaling.
Tissue factor (TF) is a cellular receptor for coagulation factor VIIa (FVIIa), and the assembly of TF:FVIIa complexes on cell surfaces not only triggers the coagulation cascade but also transduces cell signaling via activation of protease-activated receptors. This brief review summarizes recent controversial data on the importance of protein disulfide isomerase-mediated disulfide bond switching in extracellular domain of TF in regulating its coagulant and cell-signaling activities. The review also discusses the importance of TF localization in lipid rafts and caveolae in maintaining its coagulant and signaling functions.
Pendurthi
Usha R
UR
Center for Biomedical Research, The University of Texas Health Science Center, Tyler, TX 75708, USA. usha.pendurthi@uthct.edu
Rao
L Vijaya Mohan
LV
D001777:Blood Coagulation / Q000502:physiology; D021941:Caveolae / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D004220:Disulfides / Q000378:metabolism*; D005544:Forecasting; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism*; D019704:Protein Disulfide-Isomerases / Q000378:metabolism; D015398:Signal Transduction; D013925:Thromboplastin / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology
D004220:Disulfides; D013925:Thromboplastin; D019704:Protein Disulfide-Isomerases