title: [A multi-centers clinical study of different treatment outcomes of 332 patients with multiple myeloma].
abstract: OBJECTIVE
  To describe the demographic and clinical characteristics of patients with the diagnosis of multiple myeloma (MM) and to analyse the outcome of different regimens for the treatment of MM.
  
  
  METHODS
  The study reviewed 332 MM cases diagnosed within the period from January 1, 2002 to December 31, 2002. These patients were tracked via their records to a total period of three years.
  
  
  RESULTS
  First-line treatment: Totally 332 patients were included, among them 325 (97.9%) patients received chemotherapy and 7 (2.1%) patients received stem cell transplantation (SCT); Second-line treatment: 197 patients were included, among them 190 (96.5%) patients received chemotherapy and 7 (3.6%) patients received SCT; Third-line treatment: 92 patients were included,among them 88 (95.7%) patients received chemotherapy and 4 (4.4%) patients received SCT. Major adverse effects were follows: severe infection 19.3%, severe anaemia 19.3%, phlebothrombosis 1.2% , thrombocytopenia 16.9%, fever associated with neutropenia 18.1%.
  
  
  CONCLUSIONS
  Some curative effects can be achieved by using traditional treatment plans to treat patients suffering from MM, but new methods are expected to improve the prognosis.
authors.affiliation: Department of Hematology, Ruijin Hospital, being Affiliated to Shanghai Jiaotong University, Shanghai 200025, China. xuekaishanghai@126.com
authors.forename: Kai
authors.initials: K
authors.lastname: Xue
authors.forename: Lu-gui
authors.initials: LG
authors.lastname: Qiu
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Hou
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Xie-qun
authors.initials: XQ
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.forename: Jie
authors.initials: J
authors.lastname: Jin
authors.forename: De-pei
authors.initials: DP
authors.lastname: Wu
authors.forename: Yong-ji
authors.initials: YJ
authors.lastname: Wu
authors.forename: Fan-yi
authors.initials: FY
authors.lastname: Meng
authors.forename: Jian-yong
authors.initials: JY
authors.lastname: Li
authors.forename: Wen-ming
authors.initials: WM
authors.lastname: Chen
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Wang
authors.forename: Zi-lun
authors.initials: ZL
authors.lastname: Huang
authors.forename: Ping
authors.initials: P
authors.lastname: Zou
authors.forename: Shi-feng
authors.initials: SF
authors.lastname: Lou
authors.forename: Jian
authors.initials: J
authors.lastname: Ouyang
authors.forename: Fan
authors.initials: F
authors.lastname: Zhou
authors.forename: Xin
authors.initials: X
authors.lastname: Du
authors.forename: Zhi-xiang
authors.initials: ZX
authors.lastname: Shen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000209:etiology; D004358:Drug Therapy / Q000706:statistics & numerical data; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007239:Infections / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000706:statistics & numerical data; D016019:Survival Analysis; D013921:Thrombocytopenia / Q000209:etiology; D016896:Treatment Outcome