Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny.
Effects of selank on learning, memory, and attention to sensory stimuli of different modality were studied in adult Wistar rats treated with 6-hydroxydopamine (neurotoxin selectively damaging catecholaminergic neurons and their terminals) during the first 3 days of life. Selank (300 microg/kg) restored cognitive processes disordered by chronic artificial inhibition of the cerebral catecholaminergic system.
Semenova
T P
TP
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino.
Kozlovskaya
M M
MM
Zakharova
N M
NM
Kozlovskii
I I
II
Zuikov
A V
AV
D000818:Animals; D000831:Animals, Newborn; D001288:Attention / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D002395:Catecholamines / Q000378:metabolism*; D005106:Exploratory Behavior / Q000187:drug effects; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000633:toxicity; D007274:Injections, Intraperitoneal; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009498:Neurotoxins / Q000008:administration & dosage / Q000633:toxicity; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D002395:Catecholamines; D006892:Hydroxydopamines; D009498:Neurotoxins; D009842:Oligopeptides; C100827:TP 7