title: [Study of the correlation between moderately and severely chronic periodontitis and coronary heart disease].
abstract: OBJECTIVE
  To investigate the correlation between moderately and severely chronic periodontitis and coronary heart disease, as well as the role of fibrinogen in the mechanisms responsible for the correlation between periodontitis and coronary heart disease.
  
  
  METHODS
  95 subjects who were systemic health or patients of coronary heart disease with or without periodontitis were enrolled. All the subjects were placed into 4 groups based on their periodontal status and cardiovascular health. The 4 groups were healthy control group (HC), moderately and severely chronic periodontitis group (MSP), coronary heart disease group(CHD), and MSP coexisted with CHD group (MSP+CHD). Clinical periodontal index were examined, at the same time, plasma fibrinogen levels and serological changes used in diagnosing of cardiovascular disease routinely were determined. ANOVA and ANCOVA were used in the statistical analysis.
  
  
  RESULTS
  Fibrinogen levels of HC, MSP, CHD, and MSP+CHD group were (2.36+/-0.37), (3.63+/-0.73), (4.08+/-0.84), and (4.14+/-0.96) g/L, respectively. Fibrinogen levels of MSP and MSP+CHD group were significantly higher than that of healthy controls (P<0.01). The patients with moderately to severely chronic periodontitis were more likely to have coronary heart disease as compared to periodontally healthy controls (OR=2.527, P=0.047) after adjusted for blood pressure and body mass index.
  
  
  CONCLUSIONS
  Moderately and severely chronic periodontitis maybe a risk factor of coronary heart disease and fibrinogen could be one of the biological basis which links periodontitis with coronary heart disease.
authors.affiliation: Department of Periodontology, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: Song
authors.initials: S
authors.lastname: Ge
authors.forename: Ya-Fei
authors.initials: YF
authors.lastname: Wu
authors.forename: Tian-Jia
authors.initials: TJ
authors.lastname: Liu
authors.forename: Shu
authors.initials: S
authors.lastname: Meng
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
mesh_terms: D055113:Chronic Periodontitis; D003327:Coronary Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010518:Periodontitis; D012307:Risk Factors