Moderate physical training increases brain insulin concentrations in experimental diabetic rats.
Insulin is an important modulator of growth and metabolic function in the central nervous system. The aim of this study was to investigate the influence of swimming physical training (at 32 degrees +/- 1 degree C, 1 hr/day, 5 days/week, with an overload equivalent to 5% of the body weight, for 4 weeks) on brain insulin concentrations in alloxan induced type 1 diabetic rats. Training attenuated hyperglycemia but had no effect on insulinemia in diabetic rats. Hematocrit and blood albumin values remained without changes. Brain insulin did not change in diabetic rats. However, physical training increased the concentration in both control and diabetic rats. It is concluded that in the present experimental conditions, diabetes had no influence on brain insulin, however moderate physical training increased the hormone in both control and diabetic animals.
Leme
José Alexandre Curiacos de Almeida
JA
Department of Physical Education, São Paulo State University, Bela Vista, CEP 13506-900, Rio Claro, São Paulo, Brazil. zecuriacos@terra.com.br
Gomes
Ricardo José
RJ
de Mello
Maria Alice Rostom
MA
Luciano
Eliete
E
D000818:Animals; D001786:Blood Glucose; D001921:Brain / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D007328:Insulin; D006003:Glycogen