title: A brief report: the use of high-frequency oscillatory ventilation for severe pulmonary contusion.
abstract: BACKGROUND
  Severe pulmonary contusions are a common cause of acute respiratory distress syndrome (ARDS) and are associated with significant morbidity. High frequency oscillatory ventilation (HFOV) is a ventilatory mode that employs a lung protective strategy consistent with the ARDSNet low tidal volume ventilation strategy and may result in reduced morbidity. The objective of this report is to examine the impact of HFOV on blunt trauma patients with severe pulmonary contusions who failed or were at a high risk of failing conventional mechanical ventilation.
  
  
  METHODS
  We undertook a retrospective chart review of all patients at our institution who received HFOV for severe pulmonary contusions. Patients were placed on HFOV when their mean airway pressure (mP(aw)) surpassed 30 cm H2O and their FIO2 was greater than 0.6. Baseline demographic data including injury severity score (ISS), length of time requiring HFOV, total ventilator days, and inhospital mortality were collected. Serial determinations of oxygenation index (OI) and the PaO2/FIO2 ratio (P/F) were made up to 72 hours after initiation of HFOV. A linear mixed model was used to analyze the slope (beta) of the regression line of P/F versus time and that of OI versus time.
  
  
  RESULTS
  Seventeen patients were identified who underwent HFOV for ARDS due primarily to pulmonary contusions. Mean ISS was 36.6, mean APACHE II score was 21.7, and the mean time before initiation of HFOV was 2.0 days. P/F increased significantly after HFOV was initiated (beta = 12.1; 95% confidence interval 7.9 to 16.4, p < 0.001). OI significantly decreased after HFOV implementation (beta = -1.8; 95% confidence interval -2.3 to -1.3, p < 0.001). Mortality rate was 17.6%.
  
  
  CONCLUSIONS
  The early use of HFOV appears to be safe and efficacious in blunt trauma patients sustaining pulmonary contusions, and results in a rapid improvement in OI and the P/F ratio.
authors.affiliation: Division of Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: Duane J
authors.initials: DJ
authors.lastname: Funk
authors.forename: Eugenio
authors.initials: E
authors.lastname: Lujan
authors.forename: Eugene W
authors.initials: EW
authors.lastname: Moretti
authors.forename: John
authors.initials: J
authors.lastname: Davies
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Young
authors.forename: Mayur B
authors.initials: MB
authors.lastname: Patel
authors.forename: Steven N
authors.initials: SN
authors.lastname: Vaslef
mesh_terms: D018806:APACHE; D000293:Adolescent; D000328:Adult; D000368:Aged; D035641:Chest Wall Oscillation; D003288:Contusions / Q000628:therapy*; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D055370:Lung Injury; D008297:Male; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D012189:Retrospective Studies; D014949:Wounds, Nonpenetrating / Q000628:therapy*