Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors.
Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma.
Lara
Pedro Carlos
PC
Radiation Oncology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain. plara@dcc.ulpgc.es
Lloret
Marta
M
Clavo
Bernardino
B
Apolinario
Rosa Maria
RM
Bordón
Elisa
E
Rey
Agustin
A
Falcón
Orlando
O
Alonso
Ana Ruiz
AR
Belka
Claus
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D034961:Antigens, Nuclear / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D015536:Down-Regulation; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000235:genetics*; D007124:Immunoenzyme Techniques; D000072200:Ku Autoantigen; D008875:Middle Aged; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000532:radiotherapy
D034961:Antigens, Nuclear; D004268:DNA-Binding Proteins; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen