Regulation and pathological role of p53 in cisplatin nephrotoxicity.
Cisplatin is one of the most potent chemotherapy drugs widely used for cancer treatment. However, its use is limited by side effects in normal tissues, particularly the kidneys. Recent studies, using both in vitro and in vivo experimental models, have suggested a critical role for p53 in cisplatin nephrotoxicity. The signaling pathways upstream and downstream of p53 are being investigated and related to renal cell injury and death. Along with the mechanistic studies, renoprotective approaches targeting p53 have been suggested. Further research may integrate p53 signaling with other nephrotoxic signaling pathways, providing a comprehensive understanding of cisplatin nephrotoxicity and leading to the development of effective renoprotective strategies during cancer therapy.
Jiang
Man
M
Department of Cellular Biology and Anatomy, Medical College of Georgia, 1459 Laney Walker Blvd., Augusta, GA 30912, USA.
Dong
Zheng
Z
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D051017:Apoptosis Regulatory Proteins / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D020169:Caspases / Q000502:physiology; D002945:Cisplatin / Q000633:toxicity*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000502:physiology; D004249:DNA Damage; D053418:Death Domain Receptor Signaling Adaptor Proteins; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008928:Mitochondria / Q000378:metabolism; D021381:Protein Transport; D011518:Proto-Oncogene Proteins / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
D000970:Antineoplastic Agents; D051017:Apoptosis Regulatory Proteins; C438378:BBC3 protein, human; C493956:CDKN1A protein, human; D002352:Carrier Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; D053418:Death Domain Receptor Signaling Adaptor Proteins; C485896:PIDD1 protein, human; D011518:Proto-Oncogene Proteins; D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53; D020169:Caspases; D002945:Cisplatin