No association found between the insertion/deletion of a 287-bp alu repeat sequence within intron 16 of the angiotensin-I-converting enzyme (ACE) gene in Mexican patients and binary restenosis after coronary stenting.
BACKGROUND
It has been suggested that the incidence of coronary restenosis after a percutaneous coronary intervention is much higher in patients with a 287-bp alu repeat sequence within intron 16 of the angiotensin-I-converting enzyme (ACE) gene (deletion allele) than in others, but published studies are conflicting.


METHODS
The presence (insertion) or absence (deletion) of a 287-bp alu repeat sequence within intron 16 of the ACE gene (I/D polymorphism) was analyzed by polymerase chain reaction in a group of 168 patients with coronary artery disease who underwent coronary artery stenting. Basal and procedure coronary angiographies were analyzed searching for angiographic predictors of restenosis and follow-up angiography was analyzed looking for binary restenosis.


RESULTS
Distribution of angiotensin converting enzyme I/D polymorphisms was similar in patients with and without restenosis. Similar results were observed when the analysis was made considering the type of stent implanted. On the other hand, the whole group of coronary artery disease patients showed increased frequencies of the D allele (p=0.00001, OR=2.17, 95% CI=1.49-3.16) and ID genotype (p=0.0002, OR=2.58, 95%CI=1.49-4.47) when compared to healthy controls.


CONCLUSIONS
Genetic variations of the ACE gene could be a genetic factor related to coronary artery disease in the Mexican mixed racial ancestry individuals, but do not support its role as a risk factor for developing restenosis after coronary stenting.
Martínez-Ríos
Marco Antonio
MA
Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Peña-Duque
Marco Antonio
MA
Fragoso
José Manuel
JM
Delgadillo-Rodríguez
Hilda
H
Pérez-Hernández
Nonanzit
N
Miranda-Malpica
Emma
E
Rodríguez-Pérez
José Manuel
JM
González-Quesada
Carlos
C
Vargas-Alarcón
Gilberto
G
D000368:Aged; D000483:Alleles; D020087:Alu Elements / Q000235:genetics*; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006321:Heart; D006801:Humans; D054643:INDEL Mutation; D007438:Introns / Q000235:genetics; D008297:Male; D008800:Mexico; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A