Palladium-catalyzed direct C-2 arylation of indoles with potassium aryltrifluoroborate salts.
Mild conditions have been developed to achieve Pd(OAc)2-catalyzed regioselective cross-coupling between indoles and potassium aryltrifluoroarylborates in the presence of Cu(OAc)2 in acetic acid at room temperature. A variety of potassium aryltrifluoroborates selectively undergo the direct arylation across indoles and afford 2-aryl indoles in moderate to good yields.
Zhao
Jinlong
J
Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
Zhang
Yuhong
Y
Cheng
Kai
K
D001881:Borates / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011188:Potassium / Q000737:chemistry*; D012492:Salts / Q000737:chemistry; D013237:Stereoisomerism
D001881:Borates; D007211:Indoles; D009942:Organometallic Compounds; D012492:Salts; C015092:cupric acetate; D010165:Palladium; D011188:Potassium