title: Genetic screening in infertile Mexican men: chromosomal abnormalities, Y chromosome deletions, and androgen receptor CAG repeat length.
abstract: In our study, we analyzed chromosomal abnormalities, Y chromosome deletions, androgen receptor CAG repeat length and their association with defective spermatogenesis in infertile Mexican men. Eighty-two infertile patients and 40 controls were screened for karyotypic abnormalities, Y chromosome microdeletions, and CAG repeats. Nine infertile males (11%) carried chromosomal abnormalities and 10 (12.2%) presented Y chromosome microdeletions. The mean CAG repeat length was 21.6 and 20.88 base pairs in idiopathic infertile males and controls, respectively. Our results suggest that chromosomal aberrations and Y-chromosomal microdeletions are related to male infertility in Mexican men. In addition, expansion of the CAG repeat segments of the androgen receptor is not correlated with male idiopathic infertility.
authors.affiliation: Instituto de Ciencias en Reproducción Humana Vida (Instituto Vida), Plaza Las Américas 115, Col Jardines del Moral, León, Guanajuato, México CP 37160. samartin30@yahoo.com
authors.forename: Sandra Guadalupe
authors.initials: SG
authors.lastname: Martínez-Garza
authors.forename: Mayra Celina
authors.initials: MC
authors.lastname: Gallegos-Rivas
authors.forename: Marcos
authors.initials: M
authors.lastname: Vargas-Maciel
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Rubio-Rubio
authors.forename: Mario Espinosa
authors.initials: ME
authors.lastname: de Los Monteros-Rodríguez
authors.forename: Claudia
authors.initials: C
authors.lastname: González-Ortega
authors.forename: Patricia
authors.initials: P
authors.lastname: Cancino-Villarreal
authors.forename: Luis G Vazquez
authors.initials: LG
authors.lastname: de Lara
authors.forename: Antonio Martín
authors.initials: AM
authors.lastname: Gutiérrez-Gutiérrez
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D041322:Chromosomes, Human, Y / Q000235:genetics*; D020732:Cytogenetic Analysis; D005820:Genetic Testing; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008800:Mexico; D011944:Receptors, Androgen / Q000235:genetics*; D019680:Trinucleotide Repeat Expansion / Q000235:genetics*
chemical_list: D011944:Receptors, Androgen