FOXA transcription factors determine the amplitude of glucocorticoid induction of tyrosine aminotransferase in mice.
o-Aminoazotoluene was more potent than 3'-methyl-4-dimethylaminoazobenzene in modulating glucocorticoid induction of tyrosine aminotransferase and DNA-binding activity of FOXA (HNF3) in 12-day-old ICR mice. In adult animals, induction of tyrosine aminotransferase and FOXA activity were modulated by o-aminoazotoluene, while 3'-methyl-4-dimethylaminoazobenzene was ineffective. Our results suggest that FOXA proteins determine glucocorticoid induction of tyrosine aminotransferase in mice (similarly to rats).
Bryzgalov
L O
LO
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk. leon_l@ngs.ru
Ershov
N I
NI
Ilnitskaya
S I
SI
D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D005938:Glucocorticoids / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D008749:Methyldimethylaminoazobenzene; D051379:Mice; D008813:Mice, Inbred ICR; D011485:Protein Binding / Q000187:drug effects; D013997:Time Factors; D014444:Tyrosine Transaminase / Q000378:metabolism*; D009762:o-Aminoazotoluene
D051858:Forkhead Transcription Factors; D005938:Glucocorticoids; D008749:Methyldimethylaminoazobenzene; D014444:Tyrosine Transaminase; D009762:o-Aminoazotoluene