title: MHC class I assembly: out and about.
abstract: The assembly of major histocompatibility complex (MHC) class I molecules with peptides is orchestrated by several assembly factors including the transporter associated with antigen processing (TAP) and tapasin, the endoplasmic reticulum (ER) oxido-reductases ERp57 and protein disulfide isomerase (PDI), the lectin chaperones calnexin and calreticulin, and the ER aminopeptidase (ERAAP). Typically, MHC class I molecules present endogenous antigens to cytotoxic T lymphocytes (CTLs). However, the initiation of CD8(+) T-cell responses against many pathogens and tumors also requires the presentation of exogenous antigens by MHC class I molecules. We discuss recent developments relating to interactions and mechanisms of function of the various assembly factors and pathways by which exogenous antigens access MHC class I molecules.
authors.affiliation: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA. malinir@umich.edu
authors.forename: Malini
authors.initials: M
authors.lastname: Raghavan
authors.forename: Natasha
authors.initials: N
authors.lastname: Del Cid
authors.forename: Syed Monem
authors.initials: SM
authors.lastname: Rizvi
authors.forename: Larry Robert
authors.initials: LR
authors.lastname: Peters
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000276:immunology / Q000378:metabolism; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D045142:Cross-Priming / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007931:Leucyl Aminopeptidase / Q000276:immunology / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000276:immunology / Q000378:metabolism; D018448:Models, Immunological; D010455:Peptides / Q000276:immunology / Q000378:metabolism
chemical_list: D018528:ATP-Binding Cassette Transporters; D015395:Histocompatibility Antigens Class I; D026901:Membrane Transport Proteins; D010455:Peptides; C107762:tapasin; C477327:transporter associated with antigen processing (TAP); D007931:Leucyl Aminopeptidase; C456799:puromycin-insensitive leucyl-specific aminopeptidase