title: Cyclic adenosine 5'-monophosphate in synovial fluid of rheumatoid arthritis and osteoarthritis patients.
abstract: The relationship between synovial fluid (SF) cAMP level and IL-18 and PGE2 SF levels in rheumatoid arthritis (RA) and osteoarthritis (OA) patients, and between SF cAMP level and disease as well as inflammatory activity in RA were investigated in 17 RA and 19 OA patients. Erythrocyte sedimentation rate (ESR), serum (S) C-reactive protein (CRP) level and SF IL-18 level were higher in RA than in OA patients. SF PGE2 level was similar in both groups. SF cAMP level was higher in OA than in RA patients. In RA patients, SF cAMP level showed negative correlation with Disease Activity Score including a 28-joint count and S CRP, ESR and SF IL-18 level. The results suggest that cAMP promotes anti-inflammatory response in RA and OA patients, which is higher in the latter. Promotion of anti-inflammatory response by cAMP elevating agents might be useful in the treatment of RA.
authors.affiliation: Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Dubrava University Hospital, and Department of Pathophysiology, Medical School University of Zagreb, Av. G. Suska 6, Zagreb, 10040, Croatia. jmorovic@kbd.hr
authors.forename: Jadranka
authors.initials: J
authors.lastname: Morovic-Vergles
authors.forename: Melanie Ivana
authors.initials: MI
authors.lastname: Culo
authors.forename: Stjepan
authors.initials: S
authors.lastname: Gamulin
authors.forename: Filip
authors.initials: F
authors.lastname: Culo
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D015415:Biomarkers / Q000378:metabolism; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D000242:Cyclic AMP / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism; D005260:Female; D006304:Health Status; D006801:Humans; D020382:Interleukin-18 / Q000378:metabolism; D007596:Joints / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D020382:Interleukin-18; D002097:C-Reactive Protein; D000242:Cyclic AMP; D015232:Dinoprostone