Molecular and clinical investigations in patients with low-renin hypertension.
Interactions between the renin-angiotensin-aldosterone system and other mechanisms determining sodium balance are important in the pathophysiology of hypertension. Low-renin hypertension is a common type of resistant hypertension and is often associated with increased sodium retention. The importance of investigation, factors determining renin and aldosterone levels, and drug therapies in low-renin hypertension are reviewed.
Mackenzie
Isla S
IS
Hypertension Research Centre, Ninewells Hospital, University of Dundee, Level 7, Dundee, DD1 9SY, UK. I.S.Mackenzie@dundee.ac.uk
Brown
Morris J
MJ
D000450:Aldosterone / Q000097:blood; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000627:therapeutic use; D015536:Down-Regulation; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects / Q000294:innervation / Q000378:metabolism*; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System / Q000187:drug effects; D012964:Sodium / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000503:physiopathology; D016896:Treatment Outcome; D014882:Water-Electrolyte Balance
D000959:Antihypertensive Agents; D004232:Diuretics; D000450:Aldosterone; D012964:Sodium; D012083:Renin