[Alginate-chitosan microspheres for the specific sorption of antibodies].
Potentially hemocompatible alginate-chitiosan microparticles and microcapsules coated with a semipermeable membrane with incorporated glycoconjugates were synthesized. The membrane acts as a barrier, which keeps the incorporated glycoconjugate from going outside but permits antibodies to penetrate inside and specifically bind to antigens, high-molecular polysaccharide conjugates. The carriers obtained are highly competitive in sorption capacity with Sepharose modified by the same oligosaccharides.
Selina
O E
OE
Chinarev
A A
AA
Obukhova
P S
PS
Bartkowiak
A
A
Bovin
N V
NV
Markvicheva
E A
EA
D000327:Adsorption; D000464:Alginates; D000818:Animals; D001323:Autoantibodies / Q000302:isolation & purification*; D048271:Chitosan; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006801:Humans; D008567:Membranes, Artificial; D051379:Mice; D008863:Microspheres; D009844:Oligosaccharides / Q000276:immunology
D000464:Alginates; D001323:Autoantibodies; D006603:Hexuronic Acids; D008567:Membranes, Artificial; D009844:Oligosaccharides; D020723:Glucuronic Acid; D048271:Chitosan