Synthesis and biological evaluation of novel selenonucleosides.
A series of novel selenonucleoside analogues with 1,4-oxaselenane as the carbohydrate fragment has been synthesized from their corresponding dimesylated seconucleosides treated with NaHSe solution and subsequent deprotection. The synthesized selenonucleoside analogues were evaluated as potential antitumor agents.
Chen
Yao
Y
School of Pharmacy, Shanghai Jiaotong University, Shanghai, PR China.
Peng
Yingdan
Y
Zhang
Jiancun
J
Fu
Lei
L
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis*; D016566:Organoselenium Compounds / Q000138:chemical synthesis*
D000970:Antineoplastic Agents; D009705:Nucleosides; D016566:Organoselenium Compounds