Pharmacogenomic importance of ABCG2.
The ATP-binding cassette transporter ABCG2 (BCRP, MXR and ABCP) is highly expressed in the gastrointestinal tract and liver, and governs absorption, distribution and excretion of a wide variety of clinically important drugs. Common germline polymorphisms in the ABCG2 gene have been described that can affect expression, cellular localization and/or substrate recognition of the encoded protein. Alteration of transporter function by either of these mechanisms contributes significantly to interindividual variability in drug disposition and treatment outcome with certain, but not all, substrates for ABCG2.
Cusatis
George
G
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
Sparreboom
Alex
A
D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics* / Q000502:physiology; D000818:Animals; D018432:Drug Resistance, Multiple / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D064420:Drug-Related Side Effects and Adverse Reactions; D014644:Genetic Variation / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics* / Q000502:physiology; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D010597:Pharmacogenetics / Q000379:methods / Q000639:trends*; D011110:Polymorphism, Genetic / Q000187:drug effects / Q000502:physiology
C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D009363:Neoplasm Proteins; D004364:Pharmaceutical Preparations