title: [Preoperative intra-arterial chemotherapy for progressive lower rectal cancer].
abstract: OBJECTIVE
  To evaluate the therapeutic effect of preoperative regional intra-arterial chemotherapy (PRAC) on progressive lower rectal cancer.
  
  
  METHODS
  Forty-five patients with progressive lower rectal cancer were divided into groups A (23 cases) and B (22 cases) for treatment with PRAC 1 to 2 weeks prior to surgical tumor resection or with surgical resection only, respectively.
  
  
  RESULTS
  PRAC caused obvious tissue degeneration and necrosis of rectal cancer with a total effective rate of 95.65%. The rates of radical resection in groups A and B were 91.3% and 72.27%, respectively. The 1-year postoperative survival rates of the two groups were 95.65% and 86.36%, with 3-year survival of 89.96% and 68.18%, and 3-year postoperative recurrence rates of 8.69% and 27.27%, respectively. The anal preservation rates of the two groups were 78.26% and 59.09%.
  
  
  CONCLUSIONS
  PRAC can increase radical resection rates, promote the postoperative survival and anal preservation rate, and lower the recurrence rate in patients with lower rectal cancer.
authors.affiliation: Second Department of Abdominal Surgery, Affiliated Tumor Hospital of Guangzhou Medical College, Guangzhou 510095, China. tyq084@yahoo.com.cn
authors.forename: Yun-qiang
authors.initials: YQ
authors.lastname: Tang
authors.forename: Zhi-ming
authors.initials: ZM
authors.lastname: Tan
authors.forename: Jia-kang
authors.initials: JK
authors.lastname: Wang
authors.forename: Ri-jie
authors.initials: RJ
authors.lastname: Tang
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Hong-yu
authors.initials: HY
authors.lastname: Zhao
authors.forename: Cong
authors.initials: C
authors.lastname: Mai
authors.forename: Xiang-liang
authors.initials: XL
authors.lastname: Zhang
authors.forename: Shu-zhong
authors.initials: SZ
authors.lastname: Cui
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D015996:Survival Rate