title: Smoking and small, dense low-density lipoprotein particles: cross-sectional study.
abstract: All forms of tobacco cause cardiovascular disease, and tobacco-related disease is a leading cause of death worldwide. Smoking oxidizes low-density lipoprotein (LDL) particles, and oxidized LDL particles are thought to play an early and critical role in atherosclerogenesis. Hyper-low-density lipoproteinemia is one of the risk factors for cardiovascular disease, but small, dense LDL particles have been associated with an increased risk for cardiovascular disease. Small, dense LDL correlates with some cardiovascular risk factors such as diabetes mellitus, hypertriglyceridemia, hypo-high-density lipoproteinemia, and hypertension. Although smoking is also a major risk factor for cardiovascular disease, the relationship between smoking and small, dense LDL particles has not been described previously. Our cross-sectional study examined this relationship in a population of 18 healthy young adult men (9 smokers and 9 never-smokers, aged 21-24 years) from the same college. Concentrations of blood lipids and the LDL migration index (LDL-MI) were examined. Although concentrations of blood lipids did not differ between smokers and never-smokers, the LDL-MI had a strong tendency to be lower in smokers. The LDL-MI is larger in the presence of a greater proportion of small, dense LDL particles. These results indicate that tobacco smoking is associated with a decrease in the proportion of small, dense LDL particles. Regardless of these surprising results, we do not recommend smoking, given that it is a major cause of cardiovascular disease.
authors.affiliation: Medical Center for Student Health/Department of Biosignal Pathophysiology, Graduate School of Medicine, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Japan. urahama@med.kobe-u.ac.jp
authors.forename: Norinaga
authors.initials: N
authors.lastname: Urahama
authors.forename: Genzo
authors.initials: G
authors.lastname: Iguchi
authors.forename: Mitsue
authors.initials: M
authors.lastname: Shimizu
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Fujihira
authors.forename: Shunzo
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Baba
mesh_terms: D015415:Biomarkers / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D010084:Oxidation-Reduction; D012016:Reference Values; D012907:Smoking / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein