Engineering design principles for organelle size control systems.
Organelle size is an important determinant of organelle function, and for this reason cells have evolved mechanisms to control and adjust organelle size in the face of intrinsic biological fluctuations. Size control systems have been found that employ a variety of distinct mechanisms, which fall into a small number of classes. Each class represents a design principle by which artificial size controllers could be developed for synthetic biology applications.
Marshall
Wallace F
WF
Department of Biochemistry and Biophysics, University of California San Francisco, United States. wmarshall@biochem.ucsf.edu
D000818:Animals; D002477:Cells / Q000648:ultrastructure*; D006801:Humans; D053141:Organelle Size; D015388:Organelles / Q000648:ultrastructure*; D015202:Protein Engineering