Can exercise mimetics substitute for exercise?
Exercise leads to changes in muscle phenotype with important implications for exercise performance and health. A recent paper in Cell by Narkar et al. (2008) shows that many of the adaptations in muscle phenotype elicited by exercise can be mimicked by genetic manipulation and drug treatment in mice.
Richter
Erik A
EA
Molecular Physiology Group, Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark. erichter@ifi.ku.dk
Kiens
Bente
B
Wojtaszewski
Jørgen F P
JF
D055372:AMP-Activated Protein Kinases; D000222:Adaptation, Physiological / Q000502:physiology*; D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects / Q000235:genetics*; D051379:Mice; D009097:Multienzyme Complexes / Q000187:drug effects / Q000378:metabolism; D018485:Muscle Fibers, Skeletal / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects / Q000235:genetics; D047492:Peroxisome Proliferator-Activated Receptors / Q000187:drug effects / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000187:drug effects / Q000378:metabolism; D012265:Ribonucleotides / Q000494:pharmacology / Q000627:therapeutic use
D009097:Multienzyme Complexes; D047492:Peroxisome Proliferator-Activated Receptors; D012265:Ribonucleotides; D000620:Aminoimidazole Carboxamide; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases; C031143:AICA ribonucleotide