Granulomatous myositis mimicking slowly progressive lower motor neuron disease.
Here we illustrate a 74-year-old patient presenting with clinical signs of slowly progressive motor neuron disease. After electromyography demonstrated myopathic changes, a skeletal muscle biopsy was performed showing histological signs of granulomatous myositis. In extensive diagnostic workup underlying primary granulomas forming diseases were excluded and corticoid therapy was initiated, but without clinical effect. We want to point out that granulomatous myositis should be considered in the differential diagnosis of slowly progressive motor neuron diseases, especially in atypical clinical presentations.
Gdynia
Hans-Jürgen
HJ
Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany. hans-juergen.gdynia@uni-ulm.de
Osterfeld
N
N
Dorst
J
J
Ludolph
A C
AC
von Arnim
C A
CA
Sperfeld
A-D
AD
D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006099:Granuloma / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D016472:Motor Neuron Disease / Q000175:diagnosis / Q000473:pathology; D018482:Muscle, Skeletal / Q000473:pathology; D009220:Myositis / Q000175:diagnosis* / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D012507:Sarcoidosis / Q000175:diagnosis