title: Individualising netilmicin dosing in neonates.
abstract: OBJECTIVE
  The aim of this study was develop an optimal dosing regimen for netilmicin in neonates.
  
  
  METHODS
  This was a population pharmacokinetic study in 97 neonates aged from 2 to 28 days after the due date who were being treated with netilmicin for suspected sepsis. The model was used to simulate dosing regimens.
  
  
  RESULTS
  The principle factors influencing netilmicin clearance (CL) were postmenstrual age (PMA) and current body weight (CWT), and the principal determinant of volume of distribution (V) was CWT. The final covariate model was CL = 0.192 x (CWT/2)(1.35) x (PMA/40)(1.03), V = 1.5 x (CWT/2)(0.3). The optimal dosing was 5 mg/kg ever 36 h, 5 mg/kg every 24 h, 6 mg/kg every 24 h and 7 mg/kg every 24 h for neonates < or =27, 28-30, 31-33 and > or =34 weeks PMA, respectively.
  
  
  CONCLUSIONS
  Individualisation of netilmicin dosing in neonates requires adjustment of dose by body weight, and dosing interval by both PMA and CWT.
authors.affiliation: Department of Women's and Child Health, Dunedin School of Medicine, University of Otago, P.O. Box 913, Dunedin, New Zealand. catherine.sherwin@stonebow.otago.ac.nz
authors.forename: Catherine M T
authors.initials: CM
authors.lastname: Sherwin
authors.forename: Roland S
authors.initials: RS
authors.lastname: Broadbent
authors.forename: Natalie J
authors.initials: NJ
authors.lastname: Medlicott
authors.forename: David M
authors.initials: DM
authors.lastname: Reith
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001034:Apgar Score; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D008499:Medical Records; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D009428:Netilmicin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D018805:Sepsis / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D009428:Netilmicin