title: Absence of association between a functional polymorphism of ALOX15 gene and infertility in endometriosis.
abstract: The aim of the present study, involving 463 women of reproductive age, was to evaluate for the first time the relationship between endometriosis, endometriosis-related infertility, and a recently described functional polymorphism in the ALOX15 gene, reported to be essential for implantation. In our study population, ALOX15 -292 C/T was not correlated either with the risk of developing an endometriosis or with the risk of infertility.
authors.affiliation: Service de Gynécologie-Obstétrique II et Médecine de la Reproduction, Université Paris Descartes, Assistance Publique-Hôpitaux de Paris, CHU Cochin - Saint Vincent de Paul, Paris, France. bruno.borghese@inserm.fr
authors.forename: Bruno
authors.initials: B
authors.lastname: Borghese
authors.forename: Vanessa
authors.initials: V
authors.lastname: Gayet
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Chiche
authors.forename: Déwi
authors.initials: D
authors.lastname: Vernerey
authors.forename: Dominique
authors.initials: D
authors.lastname: de Ziegler
authors.forename: Catherine
authors.initials: C
authors.lastname: Bonaiti-Pellié
authors.forename: Charles
authors.initials: C
authors.lastname: Chapron
mesh_terms: D001093:Arachidonate 15-Lipoxygenase / Q000235:genetics*; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007247:Infertility, Female / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: C515716:ALOX15 protein, human; D001093:Arachidonate 15-Lipoxygenase