Selenium supplementation in autoimmune thyroiditis female patient--effects on thyroid and ovarian functions (case study).
Recently published biochemical data suggest the significant role of selenium compounds as the adjuvants combined with L: -thyroxine therapy, which can reduce antithyroid peroxidase antibodies' (TPOAb) levels in patients with Hashimoto disease. The study was undertaken to document in a more detailed way the changes in parameters expressing the thyroid and ovarian function brought about by selenium supplementation (50-100 microg/day) in a woman undergoing autoimmune thyroiditis (AIT) therapy. This prospective observational case study lasted for 14 months plus additional 5 months as a follow-up period. Parameters reflecting selenium status, thyroid metabolism, and sex hormones secretion were determined at the onset and end of the study period, as well as in some of its middle points. During the supplementation trial, serum selenium (Se) increased by 45% and plasma glutathione peroxidase (GPX3) by 21%. TPOAb decreased by 76%. All other parameters also fluctuated during the supplementation period, but all results were always within normal physiological ranges. After withdrawal of the supplementation, the sharp fall of Se and GPX3 promptly occurred, and this phenomenon was accompanied with a marked increase in TPOAb. This report stresses the importance of selenium supplementation in AIT treatment. However, the efficiency and durability of the effect of Se supplementation on the TPOAb titer remain an open question. The clarification of mechanism(s) underlying Se interaction with autoimmune processes should throw new light on this issue.
Zagrodzki
Paweł
P
Department of Food Chemistry and Nutrition, Collegium Medicum Jagiellonian University, Medyczna 9, 30-688 Krakow, Poland. Pawel.Zagrodzki@ifj.edu.pl
Ratajczak
Ryszard
R
D000906:Antibodies / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D012643:Selenium / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use*; D013961:Thyroid Gland / Q000187:drug effects / Q000503:physiopathology; D013967:Thyroiditis, Autoimmune / Q000097:blood* / Q000188:drug therapy* / Q000276:immunology; D055815:Young Adult
D000906:Antibodies; D007453:Iodide Peroxidase; D005979:Glutathione Peroxidase; D012643:Selenium