title: Simultaneous vaccination with Prevenar and multicomponent vaccines for children: interference or no interference?
abstract: Multicomponent vaccines against as many as six infectious diseases are often given simultaneously with monovalent or multivalent vaccines against meningococcus and pneumococcus. Detailed analysis of simultaneous vaccinations, which can lead to suboptimal induced immune responses, should precede their combined use in national immunization programmes. By combining the results of the only two published studies evaluating simultaneous vaccinations with Infanrix hexa and Prevanar in a random-effect meta-analysis, we show that the one-sided 95% confidence interval of the HBV seroconversion rate includes the 95% limit that should be reached in universal programs. We advocate better assessment of potential interferences in immune responses after simultaneous vaccinations. Registration of new vaccines should include this assessment.
authors.affiliation: Laboratory for Infectious Diseases and Perinatal Screening, Centre for Infectious Diseases Control Netherlands, National Institute for Public Health and the Environment, RIVM, Bilthoven, The Netherlands. Hein.Boot@RIVM.NL
authors.forename: Hein J
authors.initials: HJ
authors.lastname: Boot
authors.forename: C Maarten A
authors.initials: CM
authors.lastname: Schipper
mesh_terms: D002648:Child; D002986:Clinical Trials as Topic; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000276:immunology*; D004347:Drug Interactions; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D008589:Meningococcal Infections / Q000517:prevention & control; D011008:Pneumococcal Infections / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000276:immunology*; D017778:Vaccines, Combined / Q000276:immunology
chemical_list: D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines; D017778:Vaccines, Combined