Molecular imaging in cardiovascular magnetic resonance imaging: current perspective and future potential.
The development of novel imaging agents and techniques is allowing some biological events to be imaged in vivo with magnetic resonance imaging (MRI) at the cellular and subcellular level. In this paper, the use of novel gadolinium chelates and superparamagnetic iron oxide nanoparticles for molecular MRI of the cardiovascular system is extensively reviewed. The physical properties of these imaging agents and the pulse sequences best suited to their visualization are extensively discussed. The application of molecular MRI in diseases of the vasculature and myocardium is then reviewed. The clinical experience to date, as well as the promise and potential impact of molecular MRI, is extensively discussed.
Sosnovik
David E
DE
Department of Cardiology, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA. sosnovik@nmr.mgh.harvard.edu
D000818:Animals; D002318:Cardiovascular Diseases / Q000175:diagnosis*; D005290:Ferric Compounds; D005544:Forecasting; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000639:trends; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008967:Molecular Biology; D015336:Molecular Probe Techniques; D053758:Nanoparticles; D012680:Sensitivity and Specificity
D005290:Ferric Compounds; C000499:ferric oxide