title: DrugBank and its relevance to pharmacogenomics.
abstract: DrugBank is a freely available web-enabled database that combines detailed drug data with comprehensive drug-target and drug-action information. It was specifically designed to facilitate in silico drug-target discovery, drug design, drug-metabolism prediction, drug-interaction prediction, and general pharmaceutical education. One of the most unique and useful components of the DrugBank database is the information it contains on drug metabolism, drug-metabolizing enzymes and drug-target polymorphisms. As pharmacogenomics is fundamentally concerned with the role of genes and genetic variation of how an individual responds to a drug, DrugBank is able to offer a convenient venue to explore pharmacogenomic questions in silico. This paper provides a brief overview on DrugBank and how it can facilitate pharmacogenomic research.
authors.affiliation: Departments of Computing Science & Biological Sciences, University of Alberta, Edmonton ABT6G2E8, Canada. david.wishart@ualberta.ca
authors.forename: David S
authors.initials: DS
authors.lastname: Wishart
mesh_terms: D030541:Databases, Genetic; D015195:Drug Design; D006801:Humans; D020407:Internet / Q000639:trends; D004364:Pharmaceutical Preparations; D010597:Pharmacogenetics / Q000379:methods / Q000639:trends*
chemical_list: D004364:Pharmaceutical Preparations