Controllable one-step synthesis of spirocycles, polycycles, and di- and tetrahydronaphthalenes from aryl-substituted propargylic alcohols.
A novel, convenient, and efficient method has been developed for selective synthesis of spirocycle, polycycle, and di- and tetrahydronaphthalene systems from aryl-substituted propargylic alcohols by FeCl3- or TsOH-catalyzed multiple activations of unsaturated C-C bonds and C-H bonds.
Huang
Wen
W
Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, People's Republic of China.
Zheng
Pengzhi
P
Zhang
Zhengxing
Z
Liu
Ruiting
R
Chen
Zhenxia
Z
Zhou
Xigeng
X
D000480:Alkynes / Q000737:chemistry*; D001557:Benzenesulfonates / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D002712:Chlorides; D003500:Cyclization; D005290:Ferric Compounds / Q000737:chemistry; D008956:Models, Chemical; D009281:Naphthalenes / Q000138:chemical synthesis*; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D020005:Propanols / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis
D000480:Alkynes; D001557:Benzenesulfonates; D002712:Chlorides; D005290:Ferric Compounds; D009281:Naphthalenes; D011083:Polycyclic Compounds; D020005:Propanols; D013141:Spiro Compounds; D013764:Tetrahydronaphthalenes; C032365:benzenesulfonic acid; D002244:Carbon; C028255:propargyl alcohol; C024555:ferric chloride