title: Can neonatal myasthenia gravis be predicted?
abstract: OBJECTIVE
  To determine any association between history of mothers with myasthenia gravis (MG) and the occurrence of neonatal myasthenia gravis (NMG).
  
  
  METHODS
  The prospective study involved pregnant women with MG and their newborns delivered in our center throughout the nine-year period. The study included 16 newborns with NMG and 33 healthy newborns without symptoms of NMG. Their outcome was evaluated in relation to the duration of the illness (<5, 5-10, >10 years) and maternal therapy (no therapy, mestinon, corticosteroid, or combination of the two).
  
  
  RESULTS
  The duration of maternal illness and type of therapy were not predictive of neonatal outcomes (P=0.159, and P=0.578, respectively).
  
  
  CONCLUSIONS
  The duration of illness and therapy of women with MG do not correlate with manifestation of NMG and do not predict which pregnancies would result in an affected child. Because of possible severe, unpredictable, and life threatening NMG, these births should be carried out in a tertiary birth center.
authors.affiliation: NICU, Department of Perinatology, University Hospital for Obstetrics and Gynecology, Clinical Hospital Center Zagreb, University Medical School, Zagreb, Croatia. snjezana1@hi.t-com.hr
authors.forename: Snjezana
authors.initials: S
authors.lastname: Gveric-Ahmetasevic
authors.forename: Ana
authors.initials: A
authors.lastname: Colić
authors.forename: Vesna
authors.initials: V
authors.lastname: Elvedji-Gasparović
authors.forename: Tugomir
authors.initials: T
authors.lastname: Gverić
authors.forename: Vesna
authors.initials: V
authors.lastname: Vukelić
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis*; D020941:Myasthenia Gravis, Neonatal / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011446:Prospective Studies; D018570:Risk Assessment