title: Synthesis and structure-activity relationship studies of theophylline analogs on population responses in the rat hippocampus in vitro.
abstract: We synthesized several theophylline analogs and tested the hypothesis that these compounds may be nootropic or cognitive enhancers by examining their effects on evoked population spikes recorded extracellularly in the CA1 region of the rat hippocampus. Whereas the length of the carbon chain on N7 had no effect, different size of the terminal lactam ring strongly influenced neuroactivity. Our results suggest that hexahydroazepin-2-one analogs have potential for further development as cognitive enhancers.
authors.affiliation: Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait.
authors.forename: Kethireddy V V
authors.initials: KV
authors.lastname: Ananthalakshmi
authors.forename: Tomás
authors.initials: T
authors.lastname: Bartl
authors.forename: Mohammed H
authors.initials: MH
authors.lastname: Aziza
authors.forename: Ladislav
authors.initials: L
authors.lastname: Novotný
authors.forename: Radek
authors.initials: R
authors.lastname: Marek
authors.forename: Ludek
authors.initials: L
authors.lastname: Benes
authors.forename: Samuel B
authors.initials: SB
authors.lastname: Kombian
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004566:Electrodes; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D008297:Male; D015394:Molecular Structure; D009474:Neurons / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D018697:Nootropic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013806:Theophylline / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D018697:Nootropic Agents; D013806:Theophylline