Commensal bacteria and "oncologic surveillance": suggestions from an experimental model.
The relationship between resident intestinal flora and colon cancer development are not yet clear. Apoptosis induction could represent a mechanism by which commensal and/or probiotic bacteria could prevent proliferation of dysplastic cells. In the present study, the in vivo and in vitro proapoptotic effect of resident bacteria was evaluated in mouse colon mucosa. Preliminary results suggest that colonic apoptosis induction, by commensal bacteria, could possibly represent a physiologic "oncologic surveillance" mechanism for colonic proliferative disease prevention.
Pagnini
Cristiano
C
II School of Medicine, University of Rome La Sapienza, Rome, Italy. cristiano.pagnini@uniroma1.it
Corleto
Vito D
VD
Hoang
Sharon B
SB
Saeed
Rubina
R
Cominelli
Fabio
F
Delle Fave
Gianfranco
G
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology; D017209:Apoptosis; D053148:Caspase 3 / Q000378:metabolism; D053453:Caspase 9 / Q000378:metabolism; D003106:Colon / Q000187:drug effects / Q000382:microbiology*; D003110:Colonic Neoplasms / Q000382:microbiology* / Q000517:prevention & control*; D015169:Colony Count, Microbial; D004269:DNA, Bacterial / Q000032:analysis; D004195:Disease Models, Animal; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology*; D051379:Mice; D008806:Mice, Inbred AKR; D009924:Organ Culture Techniques / Q000379:methods; D019936:Probiotics
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D053148:Caspase 3; D053453:Caspase 9