title: Respiratory syncytial virus infections in children with acute myeloid leukemia: a report from the Children's Oncology Group.
abstract: BACKGROUND
  Morbidity and mortality related to respiratory syncytial virus (RSV) in pediatric acute myeloid leukemia (AML) is not known.
  
  
  METHODS
  We combined data from three Children's Oncology Group AML studies and determined the prevalence of RSV infection and RSV-related mortality in children treated for de novo AML.
  
  
  RESULTS
  We found that the prevalence of RSV infection ranged from 0% to 1% in induction and between 0.3 and 2.2% in consolidation. Four children died from RSV resulting in RSV-specific mortality of 0.2% among all children. However, the risk of RSV-related mortality among RSV infection episodes was high (4/40, 10%).
  
  
  CONCLUSIONS
  RSV infections and deaths are rare in pediatric AML.
authors.affiliation: Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8. lillian.sung@sickkids.ca
authors.forename: Lillian
authors.initials: L
authors.lastname: Sung
authors.forename: Todd A
authors.initials: TA
authors.lastname: Alonzo
authors.forename: Robert B
authors.initials: RB
authors.lastname: Gerbing
authors.forename: Richard
authors.initials: R
authors.lastname: Aplenc
authors.forename: Beverly J
authors.initials: BJ
authors.lastname: Lange
authors.forename: William G
authors.initials: WG
authors.lastname: Woods
authors.forename: James
authors.initials: J
authors.lastname: Feusner
authors.forename: Janet
authors.initials: J
authors.lastname: Franklin
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Patterson
authors.forename: Alan S
authors.initials: AS
authors.lastname: Gamis
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000628:therapy / Q000821:virology*; D008297:Male; D015995:Prevalence; D011379:Prognosis; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000628:therapy; D012136:Respiratory Syncytial Viruses / Q000472:pathogenicity; D012189:Retrospective Studies; D012307:Risk Factors; D033581:Stem Cell Transplantation; D015996:Survival Rate; D014184:Transplantation, Homologous