title: Successful multimodal therapies for a primary atypical teratoid/rhabdoid tumor in the cervical spine.
abstract: Atypical teratoid/rhabdoid tumor (AT/RT) occurring in the central nervous system is a high-grade malignant tumor, and its prognosis is poor for patients younger than 3 years of age. In this article, we present a case of infant AT/RT in the cervical spine and its successful treatment by intensive chemotherapy. The patient, a 1.75-year-old girl, developed an acute, progressive tetraparesis. MRI revealed a large, intradural mass in the cervical spine.Total surgical resection was performed, and the specimen was diagnosed as AT/RT. Continuously, she received intensive chemotherapy using thiotepa with autologous bone marrow transplantation. At the age of nearly 3 years, she received radiation therapy to the local tumor bed and craniospinal axis. She is now 4 years old and has been maintained in complete remission with a good clinical course and no neurological deficit. The success of this treatment for the patient was that we could prevent tumor recurrence until she was able to receive radiotherapy.
authors.affiliation: Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. syano@med.hokudai.ac.jp
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Yano
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Hida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Iwasaki
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002574:Cervical Vertebrae / Q000473:pathology*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D018335:Rhabdoid Tumor / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy; D013724:Teratoma / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy
chemical_list: D000970:Antineoplastic Agents