Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics.
Mutation of the cj1461 predicted methyltransferase gene reduced the motility of Campylobacter jejuni 81-176. Electron microscopy revealed that the mutant strain had flagella but with aberrant structure. The Deltacj1461 mutant was sevenfold more adherent to but 50-fold less invasive of INT-407 human epithelial cells than the wild type.
Kim
Joo-Sung
JS
Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA.
Li
Jiaqi
J
Barnes
If H A
IH
Baltzegar
David A
DA
Pajaniappan
Mohanasundari
M
Cullen
Thomas W
TW
Trent
M Stephen
MS
Burns
Christopher M
CM
Thompson
Stuart A
SA
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D016123:Campylobacter jejuni / Q000201:enzymology* / Q000235:genetics / Q000472:pathogenicity; D002460:Cell Line; D015254:DNA Modification Methylases / Q000235:genetics / Q000378:metabolism*; D005407:Flagella / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D005816:Genetic Complementation Test; D006801:Humans; D046529:Microscopy, Electron, Transmission; D008957:Models, Genetic; D009154:Mutation; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins; D015254:DNA Modification Methylases