title: De novo synthesis of (+)-isofregenedol.
abstract: An efficient enantioselective synthesis of (+)-isofregenedol was achieved in 13 steps from commercially available cyclohexene oxide without the use of protecting groups. The tetrahydronaphthalenic core of isofregenedol was obtained via a gold(I)-catalyzed benzannulation recently developed in our laboratory.
authors.affiliation: Department of Chemistry, 10 Marie Curie, University of Ottawa, Ottawa, Canada K1N 6N5.
authors.forename: Maxime
authors.initials: M
authors.lastname: Riou
authors.forename: Louis
authors.initials: L
authors.lastname: Barriault
mesh_terms: D002384:Catalysis; D053138:Cyclohexenes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D053138:Cyclohexenes; D009281:Naphthalenes; C532795:isofregenedol; C007193:cyclohexene oxide; D006046:Gold