The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir.
The HLA-B 5701 allele is predictive of hypersensitivity reaction to abacavir, a response herein termed "ABC-HSR." This study of 1,103 individuals infected with human immunodeficiency virus assessed the usefulness of genotyping a HCP5 single-nucleotide polymorphism (SNP), rs2395029, in relation to ABC-HSR. In populations with European ancestry, rs2395029 is in linkage disequilibrium with HLA-B 5701. The HCP5 SNP was present in all 98 HLA-B 5701-positive individuals and was absent in 999 of 1005 HLA-B 5701-negative individuals. rs2395029 was overrepresented in 25 individuals with clinically likely ABC-HSR, compared with its frequency in 175 ABC-tolerant individuals (80% vs. 2%, respectively; P < .0001). Therefore, HCP5 genotyping could serve as a simple screening tool for ABC-HSR, particularly in settings where sequence-based HLA typing is not available.
Colombo
Sara
S
Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland.
Rauch
Andri
A
Rotger
Margalida
M
Fellay
Jacques
J
Martinez
Raquel
R
Fux
Christoph
C
Thurnheer
Christine
C
Günthard
Huldrych F
HF
Goldstein
David B
DB
Furrer
Hansjakob
H
Telenti
Amalio
A
D019380:Anti-HIV Agents / Q000009:adverse effects*; D002353:Carrier State; D015331:Cohort Studies; D015224:Dideoxynucleosides / Q000009:adverse effects*; D005838:Genotype; D015235:HLA-B Antigens / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D000099227:Abacavir
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D015235:HLA-B Antigens; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D000099227:Abacavir; C080521:HCP5 long noncoding RNA, human