title: Synthesis of 3,4-benzo-7-hydroxy-2,9-diazabicyclo[3.3.1]non-7-enes by cyclization of 1,3-bis(silyl enol ethers) with quinazolines.
abstract: A variety of functionalized 3,4-benzo-7-hydroxy-2,9-diazabicyclo[3.3.1]non-7-enes were prepared by one-pot cyclizations of 1,3-bis(silyl enol ethers) with quinazolines. The mechanism of the cyclization was studied by B3LYP/6-31G(d) density functional theory computations. The products could be functionalized by Suzuki cross-coupling reactions. The reaction of 1,3-bis(silyl enol ethers) with phthalazine afforded open-chain rather than cyclization products.
authors.affiliation: Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany.
authors.forename: Vahuni
authors.initials: V
authors.lastname: Karapetyan
authors.forename: Satenik
authors.initials: S
authors.lastname: Mkrtchyan
authors.forename: Andreas
authors.initials: A
authors.lastname: Schmidt
authors.forename: Jörg-Peter
authors.initials: JP
authors.lastname: Gütlein
authors.forename: Alexander
authors.initials: A
authors.lastname: Villinger
authors.forename: Helmut
authors.initials: H
authors.lastname: Reinke
authors.forename: Haijun
authors.initials: H
authors.lastname: Jiao
authors.forename: Christine
authors.initials: C
authors.lastname: Fischer
authors.forename: Peter
authors.initials: P
authors.lastname: Langer