title: Acute sleep deprivation is associated with increased QT dispersion in healthy young adults.
abstract: BACKGROUND
  Sleep deprivation (SD) is known to be associated with worse cardiovascular outcome including mortality. We investigated the association between acute SD and electrocardiographic maximum QT interval (QTmax), QT, and corrected QT dispersion (QTd/cQTd), which are known to be among predictors of ventricular arrhythmias and sudden death.
  
  
  METHODS
  We obtained electrocardiograms of 37 healthy young volunteers (age: 28.45 +/- 7.97 years; 11 women) after a night with regular sleep and repeated after a night with sleep debt. We measured minimum QT interval (QTmin), QTmax, QTd, and cQTd in milliseconds.
  
  
  RESULTS
  Average sleep time of the subjects were 7.7 +/- 0.8 hours during regular sleep and 1.7 +/- 1.6 hours during a night with sleep debt (P < 0.001). Subjects had similar values of QTmin in milliseconds after a night of sleep debt when compared to after regular sleep (347.56 +/- 29.75 vs 344.59 +/- 20.89; P = 0.51), whereas they had significantly higher values of QTmax, QTd, and cQTd (396.48 +/- 30.11 vs 378.10 +/- 23.90; P = 0.001, 49.45 +/- 9.11 vs 33.51 +/- 10.05; P < 0.001 and 54.92 +/- 10.42 vs 37.23 +/- 10.81; P < 0.001, respectively). In Pearson's correlation analysis, QTmax, QTd, and cQTd were inversely correlated with sleep time (P = 0.012, r =-0.291; P < 0.001, r =-0.625 and P < 0.001, r =-0.616, respectively)
  
  
  CONCLUSIONS
  In conclusion, we clearly demonstrated that even one night of SD is associated with significant increase in QTmax, QTd, and cQTd in healthy young adults despite remaining within normal limits. These electrocardiographic changes in acute SD might contribute to development and/or recurrence of arrhythmias. This implication deserves further studies for clarifying the possible linkage between SD and arrhythmias.
authors.affiliation: Cardiology Department, School of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Ozer
authors.forename: Burcu
authors.initials: B
authors.lastname: Ozbala
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sari
authors.forename: Vedat
authors.initials: V
authors.lastname: Davutoglu
authors.forename: Emin
authors.initials: E
authors.lastname: Maden
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Baltaci
authors.forename: Sema
authors.initials: S
authors.lastname: Yavuz
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aksoy
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D012016:Reference Values; D012892:Sleep Deprivation / Q000150:complications* / Q000503:physiopathology*