title: Thrombolysis in patients with marked clinical fluctuations in neurologic status due to cerebral ischemia.
abstract: BACKGROUND
  It is unclear whether thrombolysis benefits patients with fluctuating neurologic symptoms.
  
  
  OBJECTIVE
  To evaluate the clinical course of patients with acute stroke who presented with marked fluctuations in neurologic status and received thrombolytic therapy.
  
  
  METHODS
  Prospective analysis.
  
  
  METHODS
  London Health Science Centre University Hospital, London. Patients We prospectively identified patients who were treated with intravenous or intra-arterial recombinant tissue plasminogen activator between January 1, 2004, and January 1, 2006. For this analysis, we chose patients who had marked fluctuation in neurologic status at presentation and who received thrombolytic therapy. Main Outcome Measure Fluctuation of neurologic deficits, defined as a 4-point or greater increase or decrease in the National Institutes of Health Stroke Scale (NIHSS) score.
  
  
  RESULTS
  Among 127 patients, 13 (10.2%) had clinical fluctuations. Patients with fluctuations presented with a lower NIHSS score (median, 7; interquartile range, 10-17) compared with patients without fluctuations (median, 12; interquartile range, 10-17) (P < .001). Fluctuation of symptoms or signs ceased after thrombolysis. At 24 hours after stroke, the median NIHSS score was 2 (range, 1-12). All patients had favorable neurologic and functional outcomes at 3 months after thrombolysis (modified Rankin scale score, 0-2).
  
  
  CONCLUSIONS
  Thrombolysis may benefit patients with fluctuating symptoms or signs due to cerebral ischemia.
authors.affiliation: Department of Neurological Sciences, London Health Science Centre, University of Western Ontario, London, Ontario,, Canada. ozcan_99@yahoo.com
authors.forename: Ozcan
authors.initials: O
authors.lastname: Ozdemir
authors.forename: Vadim
authors.initials: V
authors.lastname: Beletsky
authors.forename: Richard
authors.initials: R
authors.lastname: Chan
authors.forename: Vladimir
authors.initials: V
authors.lastname: Hachinski
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D003943:Diagnostic Techniques, Neurological / Q000639:trends; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D011446:Prospective Studies; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D010959:Tissue Plasminogen Activator