title: let-7 microRNAs in development, stem cells and cancer.
abstract: MicroRNAs (miRNAs) are small noncoding RNAs, approximately 22 nucleotides in length, that repress target messenger RNAs (mRNAs) through an antisense mechanism. The let-7 miRNA was originally discovered in the nematode Caenorhabditis elegans, where it regulates cell proliferation and differentiation, but subsequent work has shown that both its sequence and its function are highly conserved in mammals. Recent results have now linked decreased let-7 expression to increased tumorigenicity and poor patient prognosis. Moreover, during normal development, accumulation of let-7 can be prevented by LIN28, a promoter of pluripotency. Based on these findings, we propose that let-7 regulates 'stemness' by repressing self-renewal and promoting differentiation in both normal development and cancer. A more complete understanding of its function will thus provide insights into these processes and might yield diagnostic and therapeutic advances for cancer treatment.
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, P.O. Box 2543, CH-4002 Basel, Switzerland.
authors.forename: Ingo
authors.initials: I
authors.lastname: Büssing
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Slack
authors.forename: Helge
authors.initials: H
authors.lastname: Grosshans
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000196:embryology / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D009857:Oncogenes; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology; D014158:Transcription, Genetic
chemical_list: D035683:MicroRNAs; C474488:let-7 microRNA, C elegans