Catalytic asymmetric nitroaldol (Henry) reaction with a zinc-Fam catalyst.
Ferrocenyl-substituted aziridinylmethanol (Fam-1) was used as a catalyst with zinc for the asymmetric nitroaldol (Henry) reaction. This catalyst worked with a variety of aldehydes (aromatic, aliphatic, alpha,beta-unsaturated, and heteroaromatic) and alpha-ketoesters to give the nitroaldol product in up to 97% yield and 91% ee. The chiral ligand can be recovered and recycled without losing its activity.
Bulut
Adnan
A
Department of Chemistry, Kirikkale University, 71450, Kirikkale, Turkey
Aslan
Ayhan
A
Dogan
Ozdemir
O
D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D005296:Ferrous Compounds / Q000737:chemistry*; D015394:Molecular Structure; D009566:Nitrates / Q000737:chemistry; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
D000447:Aldehydes; D005296:Ferrous Compounds; D009566:Nitrates; D009574:Nitro Compounds; D009942:Organometallic Compounds; D015032:Zinc; C421036:methyl nitrate