Quantitative aspects of the early motor repertoire in preterm infants: do they predict minor neurological dysfunction at school age?
BACKGROUND
Qualitative aspects of the motor repertoire, at 11-16 weeks post-term are predictive for minor neurological dysfunction (MND) at 7 to 11 years of age. Predictive value of quantitative aspects is unknown so far.


OBJECTIVE
To investigate whether quantitative aspects of the motor repertoire between 6 and 24 weeks post-term also have predictive value for neurological outcome at 7 to 11 years of age.


METHODS
Prospective cohort study.


METHODS
Preterm infants from whom several quantitative aspects of the motor repertoire were assessed between 6 and 24 weeks post-term.


METHODS
Neurological outcome at 7-11 years of age was assessed according to Touwens' neurological examination. Children were classified as neurologically normal, or as having complex MND or cerebral palsy (CP).


RESULTS
Eighty-two children were included. At 7 to 11 years of age 15 children (18%) had developed CP, 49 (60%) were neurologically normal, and 18 (22%) had MND. Multiple logistic regression analysis showed that, when the qualitative aspects of the motor repertoire known to predict neurological outcome were taken into account, only the asymmetric tonic neck (ATN) posture provided additional predictive value. In case of normal fidgety movements (FMs) accompanied by an abnormal concurrent motor repertoire, the presence of an obligatory ATN increased the risk for developing complex MND to 75%; absence of an obligatory ATN reduced the risk to 15% (p<0.05).


CONCLUSIONS
Quantitative aspects of the motor repertoire at 11-16 weeks post-term, in particular the presence of an obligatory ATN posture, contribute to the prediction of neurological outcome at 7 to 11 years of age.
Bruggink
Janneke L M
JL
Department of Pediatrics, Division of Neonatology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, The Netherlands. j.l.m.bruggink@bkk.umcg.nl
Einspieler
Christa
C
Butcher
Phillipa R
PR
Stremmelaar
Elisabeth F
EF
Prechtl
Heinz F R
HF
Bos
Arend F
AF
D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000503:physiopathology*; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D009043:Motor Activity; D009420:Nervous System / Q000503:physiopathology*; D011187:Posture; D015203:Reproducibility of Results