title: Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors.
abstract: Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma.
authors.affiliation: Radiation Oncology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain. plara@dcc.ulpgc.es
authors.forename: Pedro Carlos
authors.initials: PC
authors.lastname: Lara
authors.forename: Marta
authors.initials: M
authors.lastname: Lloret
authors.forename: Bernardino
authors.initials: B
authors.lastname: Clavo
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Apolinario
authors.forename: Elisa
authors.initials: E
authors.lastname: Bordón
authors.forename: Agustin
authors.initials: A
authors.lastname: Rey
authors.forename: Orlando
authors.initials: O
authors.lastname: Falcón
authors.forename: Ana Ruiz
authors.initials: AR
authors.lastname: Alonso
authors.forename: Claus
authors.initials: C
authors.lastname: Belka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D034961:Antigens, Nuclear / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D015536:Down-Regulation; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000235:genetics*; D007124:Immunoenzyme Techniques; D000072200:Ku Autoantigen; D008875:Middle Aged; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000532:radiotherapy
chemical_list: D034961:Antigens, Nuclear; D004268:DNA-Binding Proteins; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen