title: Risk of complex and atypical endometrial hyperplasia in relation to anthropometric measures and reproductive history.
abstract: The authors sought to test the hypothesis that characteristics and exposures which influence the balance of estrogen and progesterone bear on the incidence of endometrial hyperplasia (EH), a noninvasive proliferation of the lining of the uterus. Cases included all female members of Group Health (Washington State) who were diagnosed with complex EH or EH with atypia during the period 1985-2003 and whose diagnoses were confirmed in a pathology review (n = 446). Controls were selected randomly from Group Health membership files and were matched to the cases by age and enrollment status at the reference date. An increased risk of EH was associated with increasing body mass index and nulliparity. There was a suggestion of a decreased risk of EH with atypia among current smokers. No association with diabetes or hypertension was found. The risk factors observed to be associated with EH in this study are similar to those associated with endometrial cancer. Whether these risk factors predispose women to cancer simply by increasing EH incidence or continue to augment cancer risk even after EH is present is currently unknown.
authors.affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. mepplein@crch.hawaii.edu
authors.forename: Meira
authors.initials: M
authors.lastname: Epplein
authors.forename: Susan D
authors.initials: SD
authors.lastname: Reed
authors.forename: Lynda F
authors.initials: LF
authors.lastname: Voigt
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Newton
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Holt
authors.forename: Noel S
authors.initials: NS
authors.lastname: Weiss
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D016001:Confidence Intervals; D004714:Endometrial Hyperplasia / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000209:etiology; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D006801:Humans; D015994:Incidence; D016347:Medical Records Systems, Computerized; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D010298:Parity; D011247:Pregnancy; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects; D014861:Washington / Q000453:epidemiology
chemical_list: D004967:Estrogens; D011960:Receptors, Estrogen