title: [Two cases of radiation-induced sarcoma after radiation therapy in nasopharyngeal carcinoma].
abstract: We report two cases of radiation-induced sarcoma after chemoradiation therapy in nasopharyngeal carcinoma. Case 1: A 40-year-old man developed a malignant peripheral nerve sheath tumor (MPNST) in the posterior floor of the nasal cavity 10 years after treatment for nasopharyngeal cancer. Case 2: A 64 year-old man developed a malignant fibrous histiocytoma (MFH) of the lower gum 10 years after treatment of nasopharyngeal cancer. Despite radical surgery, the man with MPNST had a recurrent tumor and died of the disease.
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Tohoku University Hospital, Sendai.
authors.forename: Akira
authors.initials: A
authors.lastname: Okoshi
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Shiga
authors.forename: Kazuha
authors.initials: K
authors.lastname: Sasaki
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Asada
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Mika
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005472:Fluorouracil / Q000008:administration & dosage; D051677:Histiocytoma, Malignant Fibrous / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D018317:Nerve Sheath Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin; D005472:Fluorouracil