Relationship between free-radical lipid oxidation and efficiency of coronary angioplasty in coronary patients.
Low-dose (250 mg daily) oral probucol produces a significant antioxidant effect in coronary patients: increases activity of glutathione peroxidase (enzyme utilizing lipoperoxides) and reduces the content of free-radical oxidation products in the blood. Probucol therapy for 7 days before and for 6 months after coronary angioplasty significantly reduces the severity of coronary artery stenosis.
Kaminnyi
A I
AI
A. L. Myasnikov Institute of Cardiology, Russian Cardiological Center, Russian Ministry of Health, Moscow. akam67@rambler.tu
Lankin
V Z
VZ
Perepelitsa
E I
EI
Konovalova
G G
GG
Samko
A N
AN
Tikhaze
A K
AK
Kukharchuk
V V
VV
Belenkov
Yu N
YN
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy; D005609:Free Radicals / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011341:Probucol / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
D000975:Antioxidants; D005609:Free Radicals; D005979:Glutathione Peroxidase; D011341:Probucol