Differential contributions of spinal and cortical motoneurons to input-output properties of human small hand muscle.
OBJECTIVE
It is not fully understood how the stimulus/response curves obtained by transcranial magnetic stimulation (TMS) reflect the function of the cortico-motoneuronal (CM) and spinal motoneuronal (SM) systems in healthy subjects. To understand these response functions, we studied patients with amyotrophic lateral sclerosis (ALS) whose upper but not lower motor neurons were affected.


METHODS
First, we determined the effects of voluntary muscle contraction and intensity of TMS on the motor evoked potentials (MEPs) of the first dorsal interossei (FDI) muscle in ten healthy control subjects (mean age: 35.1 +/- 6.7 years) and two older female subjects (60 and 64 years old). Second, we investigated whether this relationship was altered in two ALS patients (60-year-old woman and 69-year-old man). The MEPs were recorded at different degrees of voluntary contraction by threshold stimulus intensities (TSIs) or at different levels of TMS with the muscle at rest.


RESULTS
In the controls, the MEP amplitudes of the FDI muscle elicited by TSI increased linearly with muscle contraction (right: Y = 0.068X + 0.754; left: Y = 0.0670X + 0.807), whereas the MEP amplitudes elicited by different TMS intensities increased sigmoidally with a flexion point at 1.10-1.15 TSI: right: Amp = 2.21/[1 + exp[(S50-Stim)/K]], S50 = 10.73, K = 4.70; left: Amp = 2.90/[1 + exp[(S(50)-Stim)/K]], S50 = 13.64, K = 5.98. The latter was abnormal only on one side of each ALS patient.


CONCLUSIONS
From these results, we suggest that the sigmoidal TMS intensity-size curves reflect mainly CM activities, while the linear contraction-size curves reflect SM activities.
Oishi
Ayame
A
Department of Neurology, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan. daichan@suo.bbiq.jp
Tobimatsu
Shozo
S
Ogata
Katsuya
K
Taniwaki
Takayuki
T
Kinukawa
Naoko
N
Toyoshiba
Hiroyoshi
H
Kira
Jun-Ichi
J
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology / Q000503:physiopathology; D000704:Analysis of Variance; D002540:Cerebral Cortex / Q000473:pathology*; D004558:Electric Stimulation; D004576:Electromyography; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006225:Hand; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology / Q000528:radiation effects; D018482:Muscle, Skeletal / Q000294:innervation*; D013116:Spinal Cord / Q000473:pathology*; D050781:Transcranial Magnetic Stimulation