Effect of Lidan Granule on bile lithogenesis in patients with choledocholithiasis combined with cholecystolithiasis.
OBJECTIVE
To observe the effect of Lidan Granule (, LDG) on bile lithogenic tendency and biliary 33.5 kd vesicular protein (VP) and to explore its mechanism.


METHODS
Sixty patients with choledocholithiasis combined with cholecystolithiasis were randomly assigned to the LDG treated group, the sodium cholate treated group for positive control, and the untreated control group, 20 patients in each group. The 4 bile lithogenic trend indexes, including lithogenic index (LI), unconjugated bilirubin percent (UCB%), unconjugated bilirubin saturation index (BSI) and Z-value, were determined before and after treatment. The content of VP in bile was determined as well.


RESULTS
Before treatment, the LI, UCB%, BSI and Z-value in the LDG treated group were 1.298+/- 0.265, 34.72+/-2.96, 0.353+/-0.093 and 0.556+/-0.499, respectively, which was decreased after the 2-week treatment to 0.926+/-0.208, 8.93+/-1.19, 0.154+/-0.056 and 0.257+/-0.211, respectively (all P<0.05). Meantime, the content of VP was also lowered from 0.050+/-0.005 g/L to 0.032+/-0.005 g/L. However, no significant change in any of the above-mentioned indexes was found in the other two groups.


CONCLUSIONS
LDG could effectively suppress bile lithogenic trend and reduce 33.5 kd VP in bile.
Xiang
Yang
Y
Department of General Surgery, Huashan Hospital of Fudan University, Shanghai, China.
Chen
Jin-hong
JH
Cai
Duan
D
Ma
Bao-jin
BJ
D000368:Aged; D001646:Bile / Q000378:metabolism*; D041761:Cholecystolithiasis / Q000150:complications* / Q000188:drug therapy*; D042883:Choledocholithiasis / Q000150:complications* / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D004365:Drugs, Chinese Herbal; C531143:lidan