Synthesis and biological evaluation of novel 3'-N-tert-butylsulfonyl analogues of docetaxel.
Novel 3'-N-tert-butylsulfonyl analogues 10a-c of docetaxel were synthesized and their biological evaluation in cytotoxicity in vitro against several human tumor cell lines were presented. The biologically tested results showed that N-oxide pyridyl substituted10b-c had potent cytotoxicities against human tumor cell lines Eca-109, SKOV3, SMMC-7721, HCT-8, PC3, MCF-7, HeLa and KB.
Ke
Bowen
B
Department of Chemistry of Medicinal Natural Products, Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
Qin
Yong
Y
Zhao
Fengyan
F
Qu
Yi
Y
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D000077143:Docetaxel; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology; D013451:Sulfonic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D043823:Taxoids / Q000138:chemical synthesis* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D013451:Sulfonic Acids; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel