title: [Primary natural killer/T cell lymphoma of the lung: two cases report and clinical analysis].
abstract: OBJECTIVE
  To describe the clinical and pathological features of primary NK/T cell lymphoma of the lung.
  
  
  METHODS
  Two cases of primary NK/T cell lymphoma of the lung were reported, and the clinical, radiological and pathological characteristics of the disease were discussed with literature review of 3 cases.
  
  
  RESULTS
  Most patients presented with fever, cough and dyspnea, and antibiotics were ineffective. Radiographic findings included solitary or multiple nodules and consolidation, unilateral orbilateral pleural effusions (4/5), without hilar or mediastinal adenopathy. Ebstein-Barr virus was positive in cases patients (3/5). Histopathology revealed a great deal of abnormal lymphocyte infiltration, which were angio-centric with marked tissue putrescence and angio-destruction. Immunophenotyping showed CD56(+), CD3(+), perform (+), T-cell intracytoplasmic antigen-1(+) and/or GranB(+), but CD20(-). Most patients died of respiratory failure in half a year (4/5).
  
  
  CONCLUSIONS
  Primary NK/T cell lymphoma of the lung is rare, but should be considered when patients present with lung shadows and fever non-responsive to antibiotics, decreased WBC and increased LDH.
authors.affiliation: Department of Respiratory Medicine, The Affiliated Drum Tower Hospital, Nanjing University Medical College, Nanjing 210008, China.
authors.forename: Meng-Shu
authors.initials: MS
authors.lastname: Cao
authors.forename: Hou-Rong
authors.initials: HR
authors.lastname: Cai
authors.forename: Hong-Lin
authors.initials: HL
authors.lastname: Yin
authors.forename: De-Ping
authors.initials: DP
authors.lastname: Zhang
authors.forename: Yong-Long
authors.initials: YL
authors.lastname: Xiao
authors.forename: Min
authors.initials: M
authors.lastname: Cao
authors.forename: Ling-Juan
authors.initials: LJ
authors.lastname: Dai
authors.forename: Jie
authors.initials: J
authors.lastname: Hou
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology; D054391:Lymphoma, Extranodal NK-T-Cell / Q000276:immunology / Q000473:pathology; D055815:Young Adult