[Proteinuria and renal transplantation].
The occurrence of proteinuria in transplant patients is a marker of poor prognosis. The augmentation of proteinuria is associated with an increased risk of patient death and graft loss. Even a low-level urinary protein excretion (0.5 g/d) has a highly significant negative impact on graft survival whether it is observed 1 or 3 months after transplantation. Urinary albumin excretion rate has also a major effect on risks of graft loss and death with functional kidney, macro-albuminuria increasing the risks of respectively 16.4 and 4.12 times comparatively to micro-albuminuria, which itself multiplies the risks by 14.2 and 5.5 respectively, compared to normo-albuminuria. In terms of factors causing proteinuria apparition, the role of proliferation signal inhibitors has been recently observed. Sirolimus, especially at high dose, in particular can induce the occurrence of proteinuria, which is reversible with treatment discontinuation, but only with a partial recovery of the renal function. Proteinuria may be explained by a direct glomerular impact of sirolimus on several podocyte markers.
Legendre
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Service de néphrologie A1-Transplantation adultes, Hôpital Necker-Enfants malades, 149, rue de Sèvres, 75743 Paris cedex 15, France. christophe.legendre@nck.ap-hop-paris.fr
D006131:Growth Inhibitors / Q000009:adverse effects; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D011507:Proteinuria / Q000209:etiology*
D006131:Growth Inhibitors