GSK-3beta is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity.
McCubrey
James A
JA
Department of Microbiology & Immunology, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27858, USA. mccubreyj@ecu.edu
Bäsecke
Jörg
J
Cervello
Melchiorre
M
Martelli
Alberto M
AM
Franklin
Richard A
RA
D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis; D044182:Benzylisoquinolines / Q000494:pharmacology*; D045744:Cell Line, Tumor; D019938:Cyclin D1 / Q000378:metabolism; D050760:Cyclin-Dependent Kinase Inhibitor p27; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005786:Gene Expression Regulation; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*
D000970:Antineoplastic Agents; D044182:Benzylisoquinolines; C436291:CDKN1B protein, human; D004791:Enzyme Inhibitors; D047908:Intracellular Signaling Peptides and Proteins; D019938:Cyclin D1; D050760:Cyclin-Dependent Kinase Inhibitor p27; C009438:tetrandrine; D019869:Phosphatidylinositol 3-Kinases; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3