Assessment of biochemical recurrence rate in patients with pathologically confirmed insignificant prostate cancer.
OBJECTIVE
To examine the rate of biochemical recurrence (BCR) in patients with pathologically confirmed insignificant prostate cancer (PIPCa).


METHODS
A total of 1358 patients underwent open retropubic radical prostatectomy at the University Medical Center Eppendorf in Hamburg, Germany, and their specimens were whole-mounted, step-sectioned, and subjected to computer-based three-dimensional reconstruction. We identified patients who fulfilled the Epstein criteria for definition of PIPCa (tumor volume <or=0.5 mL, Gleason score <or=6, organ-confined disease) and we compared the BCR-free rates between the PIPCa and non-PIPCa groups.


RESULTS
Pathologically confirmed insignificant prostate cancer was found in 69 patients (5%). At 1, 2, 5, and 10 years, the BCR-free rate for PIPCa patients was 100% vs, respectively, 97%, 91%, 74%, and 38% for other patients (log-rank P <.0001).


CONCLUSIONS
In patients with PIPCa, radical prostatectomy results in perfect biochemical recurrence rates, which confirms the validity of the PIPCa definition.
Capitanio
Umberto
U
Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, QC, Canada.
Ahyai
Sasha
S
Graefen
Markus
M
Jeldres
Claudio
C
Shariat
Shahrokh F
SF
Erbersdobler
Andreas
A
Schlomm
Thorsten
T
Haese
Alexander
A
Steuber
Thomas
T
Heinzer
Hans
H
Perrotte
Paul
P
Péloquin
François
F
Pharand
Daniel
D
Arjane
Philippe
P
Huland
Hartwig
H
Karakiewicz
Pierre I
PI
D000328:Adult; D000368:Aged; D001706:Biopsy; D015331:Cohort Studies; D018572:Disease-Free Survival; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D011467:Prostate / Q000473:pathology / Q000601:surgery; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D012008:Recurrence; D016896:Treatment Outcome