title: Cytomegalovirus prostatitis: a series of 4 cases.
abstract: Cytomegalovirus (CMV) prostatitis is very rare with only 1 report of biopsy-proven CMV prostatitis in the literature. The authors report 4 cases, 3 detected on needle biopsy and 1 detected on transurethral resection. Patients were 36, 41, 48, and 71 years old. All patients were immunosuppressed, including 1 with AIDS and 3 undergoing immunosuppressive therapy following organ transplantation. CMV inclusions were seen in secretory cells of the prostatic glands, endothelial cells of small vessels, and prostatic stromal cells associated with a dense lymphoid inflammation. Only very rarely is CMV prostatitis detected on clinical specimens, typically in immunosuppressed hosts undergoing immunosuppressive therapy following organ transplantation. Patients with CMV prostatitis may harbor multiple infections or have other serious medical conditions adversely affecting their prognosis.
authors.affiliation: Department of Pathology, the Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
authors.forename: Ghil-Suk
authors.initials: GS
authors.lastname: Yoon
authors.forename: Michael S
authors.initials: MS
authors.lastname: Nagar
authors.forename: Fabio
authors.initials: F
authors.lastname: Tavora
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Epstein
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D004730:Endothelium, Vascular / Q000473:pathology / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects / Q000473:pathology; D011183:Postoperative Complications / Q000276:immunology / Q000473:pathology / Q000821:virology; D011467:Prostate / Q000473:pathology / Q000821:virology; D011472:Prostatitis / Q000276:immunology / Q000473:pathology / Q000821:virology*; D020728:Transurethral Resection of Prostate