title: 111/121 diplotype of Calpain-10 is associated with the risk of polycystic ovary syndrome in Korean women.
abstract: We investigated whether the CAPN-10 polymorphism UCSNP-43, -19, and -63 contribute, either individually or as haplotype/diplotype, to the susceptibility of polycystic ovary syndrome (PCOS) or related quantitative traits in Korean women. Our data showed that 111 haplotype and 111/121 and 111/111 diplotypes in the CAPN-10 gene were associated with a significantly increased risk of PCOS, and 112 haplotype and 121/121 and 112/122 diplotypes were associated with decreased risk of PCOS in the Korean population.
authors.affiliation: Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Woon Jeong
authors.initials: WJ
authors.lastname: Lee
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Hur
authors.forename: Chul Min
authors.initials: CM
authors.lastname: Lee
authors.forename: Yeon-Ah
authors.initials: YA
authors.lastname: Sung
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Chung
mesh_terms: D000328:Adult; D002154:Calpain / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D015994:Incidence; D007723:Korea / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
chemical_list: D002154:Calpain; C415197:calpain 10