Chronic anterior uveitis following bacille Calmette-Guérin vaccination: molecular mimicry in action?
A 13-year-old girl developed bilateral chronic anterior uveitis following bacille Calmette-Guérin (BCG) vaccination. HLA testing was negative for B27 but positive for DRB1 *0404, a variant of DR4 often associated with rheumatoid arthritis. The authors propose her HLA repertoire allowed for a BCG-induced abnormal autoimmune response by the mechanism of molecular mimicry.
Spratt
Alexander
A
Department of Ophthalmology, West Suffolk Hospital NHS Trust, Bury St. Edmunds, UK.
Key
Tim
T
Vivian
Anthony J
AJ
D000293:Adolescent; D000483:Alleles; D001500:BCG Vaccine / Q000009:adverse effects*; D002908:Chronic Disease; D005260:Female; D007839:Functional Laterality; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D018716:Molecular Mimicry / Q000235:genetics*; D016133:Polymerase Chain Reaction; D014376:Tuberculosis / Q000517:prevention & control; D014606:Uveitis, Anterior / Q000209:etiology* / Q000235:genetics; D014611:Vaccination
D001500:BCG Vaccine; C488436:HLA DRB1*04:04 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains