Targeted radionuclide therapy.
Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake, in percent-injected dose per gram of malignant tissue, is used to evaluate the specificity of the targeting vehicle. Lymphoma (B-cell) has been the primary clinical application. Extension to solid tumors will require raising the macroscopic absorbed dose by several-fold over values found in present technology. Methods that may effect such changes include multistep targeting, simultaneous chemotherapy, and external sequestration of the agent. Toxicity has primarily involved red marrow so that marrow replacement can also be used to enhance future TRT treatments. Correlation of toxicities and treatment efficiency has been limited by relatively poor absorbed dose estimates partly because of using standard (phantom) organ sizes. These associations will be improved in the future by obtaining patient-specific organ size and activity data with hybrid SPECT/CT and PET/CT scanners.
Williams
Lawrence E
LE
Radiology Division, City of Hope National Medical Center, Duarte, California 91010, USA. lwilliams@coh.org
DeNardo
Gerald L
GL
Meredith
Ruby F
RF
D001853:Bone Marrow / Q000378:metabolism / Q000528:radiation effects; D015902:Gamma Cameras; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008495:Medical Oncology / Q000379:methods; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000379:methods; D018787:Radiation Oncology / Q000379:methods*; D016499:Radioimmunotherapy / Q000379:methods*; D011868:Radioisotopes / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D015021:Yttrium Radioisotopes / Q000627:therapeutic use
D007457:Iodine Radioisotopes; D011868:Radioisotopes; D015021:Yttrium Radioisotopes