title: Old and new targets for innovative antimalarial compounds: the different strategies of the Italian Malaria Network.
abstract: Clinical treatment-failures to affordable drugs encouraged new investigation for discovery and development of new prophylactic and therapeutic interventions against malaria. The Drug Discovery Cluster (DDcl) of the Italian Malaria Network gathers several highly integrated and complementary laboratories from different Italian Institutions to identify, synthesise, screen in vitro and in vivo new antimalarial molecules directed against the intraerythrocytic stage of P. falciparum parasites and/or with transmission blocking activity to select lead compounds for further development. Complementary research activities, both in vitro and in the clinics, aim at investigating the pathogenetic mechanisms of severe malaria anaemia and the different manifestations of the disease in malaria-HIV co-infected patients to identify new therapies and improve survival.
authors.affiliation: Dipartimento Salute Pubblica-Microbiologia-Virologia, Università di Milano, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Basilico
authors.forename: E
authors.initials: E
authors.lastname: Bosisio
authors.forename: F
authors.initials: F
authors.lastname: Buelli
authors.forename: G
authors.initials: G
authors.lastname: Campiani
authors.forename: M
authors.initials: M
authors.lastname: Casagrande
authors.forename: F
authors.initials: F
authors.lastname: Castelli
authors.forename: P
authors.initials: P
authors.lastname: Coghi
authors.forename: Y
authors.initials: Y
authors.lastname: Corbett
authors.forename: L
authors.initials: L
authors.lastname: Cortelezzi
authors.forename: S
authors.initials: S
authors.lastname: D'Alessandro
authors.forename: M
authors.initials: M
authors.lastname: Dell'Agli
authors.forename: F
authors.initials: F
authors.lastname: Esposito
authors.forename: C
authors.initials: C
authors.lastname: Fattorusso
authors.forename: E
authors.initials: E
authors.lastname: Fattorusso
authors.forename: S
authors.initials: S
authors.lastname: Finaurini
authors.forename: G V
authors.initials: GV
authors.lastname: Galli
authors.forename: S
authors.initials: S
authors.lastname: Gemma
authors.forename: A
authors.initials: A
authors.lastname: Habluetzel
authors.forename: L
authors.initials: L
authors.lastname: Lucantoni
authors.forename: S
authors.initials: S
authors.lastname: Melato
authors.forename: D
authors.initials: D
authors.lastname: Monti
authors.forename: P
authors.initials: P
authors.lastname: Olliaro
authors.forename: F
authors.initials: F
authors.lastname: Omodeo-Salè
authors.forename: S
authors.initials: S
authors.lastname: Parapini
authors.forename: M
authors.initials: M
authors.lastname: Persico
authors.forename: M
authors.initials: M
authors.lastname: Rizzi
authors.forename: S
authors.initials: S
authors.lastname: Romeo
authors.forename: F
authors.initials: F
authors.lastname: Rossi
authors.forename: C
authors.initials: C
authors.lastname: Rusconi
authors.forename: A
authors.initials: A
authors.lastname: Sparatore
authors.forename: O Taglialatela
authors.initials: OT
authors.lastname: Scafati
authors.forename: E
authors.initials: E
authors.lastname: van den Bogaart
authors.forename: D
authors.initials: D
authors.lastname: Taramelli
authors.forename: N
authors.initials: N
authors.lastname: Vaiana
authors.forename: S
authors.initials: S
authors.lastname: Yerbanga
mesh_terms: D000818:Animals; D000852:Anopheles / Q000187:drug effects / Q000378:metabolism / Q000469:parasitology; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use; D016503:Drug Delivery Systems; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D006801:Humans; D007303:Insect Vectors / Q000187:drug effects / Q000378:metabolism / Q000469:parasitology; D007306:Insecticides / Q000494:pharmacology* / Q000627:therapeutic use; D007558:Italy; D007737:Kynurenine / Q000378:metabolism; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology / Q000635:transmission; D051379:Mice; D008807:Mice, Inbred BALB C; D021261:Parasitic Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects; D012958:Societies, Scientific / Q000458:organization & administration*
chemical_list: D000962:Antimalarials; D001688:Biological Products; D007306:Insecticides; D010936:Plant Extracts; D007737:Kynurenine