Interactomics in the human intestine: Lactobacilli and Bifidobacteria make a difference.
Scientific evidence that supports a correlation between our intestinal microbiota and health status has caused significant interest in microbe-host interaction studies. It has generated a paradigm shift from analyzing pathogens to that involving commensal and probiotic bacteria. This review summarizes the interaction mechanisms described for Lactobacilli and Bifidobacteria based on recent omics-based developments. This information is expected to provide new avenues for further unravelling the set of interactions that includes the interactome of microbial and host cells.
Boesten
Rolf J
RJ
Microbiology Department, TNO Quality of Life, Zeist, The Netherlands. rolf.boesten@wur.nl
de Vos
Willem M
WM
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001644:Bifidobacterium / Q000235:genetics / Q000378:metabolism*; D003106:Colon / Q000378:metabolism / Q000382:microbiology*; D020869:Gene Expression Profiling; D006801:Humans; D007082:Ileum / Q000378:metabolism / Q000382:microbiology*; D007778:Lactobacillus / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D011506:Proteins / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; D011506:Proteins