title: [Synthesis of diethyl N-[p-(methylamino)benzoyl]-L-glutamate].
abstract: OBJECTIVE
  To find a best synthesis method of diethyl N-[p-(methylamino)benzoyl]-L-glutamate(1).
  
  
  METHODS
  Using diethyl N-(p- aminobenzoyl)-L-glutamate (2) as a starting material via a one-pot process of benzylation and methylation, the diethyl N-[p-(methylamino)benzoyl ]-L-glutamate (3) is prepared in high yield. Then compound 1 was conveniently obtained from debenzylation of compound 3 by Pd/C.
  
  
  RESULTS
  The target compound was obtained through 2-step reaction in 88% overall yield in only 6 h, and its structure was identified by 1HNMR and MS.
  
  
  CONCLUSIONS
  It is a convenient and efficient method of preparation of diethyl N-[p-(methylamino)benzoyl]-L-glutamate.
authors.affiliation: Department of Chemical Biology, Peking University School of Pharmaceutical Sciences, Beijing 100083, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Tian
authors.forename: Shou-xin
authors.initials: SX
authors.lastname: Zhou
authors.forename: Biao
authors.initials: B
authors.lastname: Wang
authors.forename: Xi-ling
authors.initials: XL
authors.lastname: Deng
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
authors.forename: Zhi-li
authors.initials: ZL
authors.lastname: Zhang
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Wang
authors.forename: Jun-yi
authors.initials: JY
authors.lastname: Liu
mesh_terms: D005971:Glutamates / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D005971:Glutamates; C550018:diethyl N-(p-(methylamino)benzoyl)-L-glutamate; C011829:glutamic acid diethyl ester