In vitro antiprotozoal activity of some xanthones isolated from the roots of Andrographis paniculata.
Four xanthones isolated from the roots of Andrographis paniculata were tested in vitro for antiprotozoal activity against Trypanosoma brucei brucei, Trypanosoma cruzi and Leishmania infantum. Compound TDR13011 (1,2-dihydroxy-6,8-dimethoxy-xanthone) showed good activity against T. b. brucei and L. infantum with a 50% inhibitory concentration (IC50) of 4.6 microg/ml and 8 microg/ml respectively. Xanthones from the roots of Andrographis paniculata exhibited promising anti-protozoal activity and these compounds could be chemically modified to obtain a more potent product.
Dua
Virendra K
VK
National Institute of Malaria Research, Field Unit, Sector III, BHEL, Hardwar 249 403, India. vkdua51@gmail.com
Verma
Gaurav
G
Dash
A P
AP
D035685:Andrographis / Q000737:chemistry*; D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D018314:Leishmania infantum / Q000187:drug effects; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D018517:Plant Roots / Q000737:chemistry; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014349:Trypanosoma cruzi / Q000187:drug effects; D044004:Xanthones / Q000302:isolation & purification / Q000494:pharmacology*
C534994:2-dihydroxy-6,8-dimethoxy-xanthone; D000981:Antiprotozoal Agents; D044004:Xanthones