title: Early pathogenesis of experimental reovirus infection in chickens.
abstract: One-day-old specific-pathogen-free, light hybrid chickens were infected orally with an avian arthrotropic reovirus and examined at intervals from 2 h until 12 days after infection. Entry, primary replication and spread of virus were studied by infectivity assay, immunohistochemical study and electron microscopy in a wide range of tissues. These showed viral entry and primary replication in the epithelium of intestine and bursa of Fabricius within 12 h after oral infection. These were followed by a rapid and pantropic distribution of virus which reached most tissues within 24 to 48 h after infection.
authors.affiliation: Department of Veterinary Pathology, University of Liverpool, Neston, Wirral, England.
authors.forename: R C
authors.initials: RC
authors.lastname: Jones
authors.forename: M R
authors.initials: MR
authors.lastname: Islam
authors.forename: D F
authors.initials: DF
authors.lastname: Kelly