[Synthesis of diethyl N-[p-(methylamino)benzoyl]-L-glutamate].
OBJECTIVE
To find a best synthesis method of diethyl N-[p-(methylamino)benzoyl]-L-glutamate(1).


METHODS
Using diethyl N-(p- aminobenzoyl)-L-glutamate (2) as a starting material via a one-pot process of benzylation and methylation, the diethyl N-[p-(methylamino)benzoyl ]-L-glutamate (3) is prepared in high yield. Then compound 1 was conveniently obtained from debenzylation of compound 3 by Pd/C.


RESULTS
The target compound was obtained through 2-step reaction in 88% overall yield in only 6 h, and its structure was identified by 1HNMR and MS.


CONCLUSIONS
It is a convenient and efficient method of preparation of diethyl N-[p-(methylamino)benzoyl]-L-glutamate.
Tian
Chao
C
Department of Chemical Biology, Peking University School of Pharmaceutical Sciences, Beijing 100083, China.
Zhou
Shou-xin
SX
Wang
Biao
B
Deng
Xi-ling
XL
Guo
Ying
Y
Zhang
Zhi-li
ZL
Wang
Xiao-wei
XW
Liu
Jun-yi
JY
D005971:Glutamates / Q000138:chemical synthesis* / Q000737:chemistry*
D005971:Glutamates; C550018:diethyl N-(p-(methylamino)benzoyl)-L-glutamate; C011829:glutamic acid diethyl ester