New PMMA-co-EHA glass-filled composites for biomedical applications: Mechanical properties and bioactivity.
A bioactive glass of the 3CaO.P(2)O(5)-MgO-SiO(2) system was incorporated as a filler into poly(methylmethacrylate)-co-(ethylhexylacrylate) (PMMA-co-EHA) copolymer. The effect of filler proportion (0, 30, 40 and 50wt.%) on the bending properties was evaluated and a maximum flexural strength of 29MPa coupled with an elastic modulus of 1.1GPa was obtained at an intermediate filler concentration (30wt.%). These values are slightly higher than those usually reported for human cancellous bone. The in vitro bioactivity was assessed by determining the changes in surface morphology and composition after soaking in simulated body fluid (SBF, Kokubo solution). Inductively coupled plasma was used to trace the evolution of ionic concentrations in the SBF solution, namely Ca and P. X-ray diffraction and scanning electron microscopy confirmed the growth of spherical calcium phosphate aggregates on the surface of composites, indicating that the composites are potentially bioactive.
Lopes
Poliana
P
CICECO, Department of Glass and Ceramic Engineering, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal. polianap@ua.pt
Corbellini
Marcelo
M
Ferreira
Bárbara Leite
BL
Almeida
Nuno
N
Fredel
Márcio
M
Fernandes
Maria Helena
MH
Correia
Rui
R
D000179:Acrylates / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids / Q000737:chemistry; D001842:Bone and Bones / Q000378:metabolism; D002130:Calcium Phosphates / Q000737:chemistry; D005898:Glass / Q000737:chemistry*; D006801:Humans; D008768:Methylmethacrylates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010758:Phosphorus / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D011312:Pressure; D013314:Stress, Mechanical; D013499:Surface Properties; D014961:X-Ray Diffraction
D000179:Acrylates; D001672:Biocompatible Materials; D002130:Calcium Phosphates; D008768:Methylmethacrylates; D011108:Polymers; C539373:poly(methylmethacrylate)-co-(ethylhexylacrylate); D010758:Phosphorus; D019904:Polymethyl Methacrylate; C020243:calcium phosphate