title: Arterial flow measurements during reactive hyperemia using NIRS.
abstract: Non-invasive evaluation of peripheral perfusion may be useful in many contexts including clinical research. We validated a novel non-invasive spectroscopy technique to quantify forearm arterial inflow. This method, which is based on the measurement of tissular total hemoglobin variations after an ischemic period, was compared to strain gauge plethysmography (SGP). The technique uses near-infrared spectroscopy (NIRS) to determine the rate of change of forearm tissue oxygenation during reactive hyperemia. In this study, 13 subjects were simultaneously evaluated with NIRS and SGP. Nine baseline flow measurements were performed to assess the reproducibility of each method. Twenty-seven serial measurements were then made to evaluate flow variation during forearm reactive hyperemia. SGP and NIRS methods showed excellent reproducibility with the same intra-class correlation coefficients (0.98). In conclusion, the NIRS technique appears well suited for non-invasive evaluation of quantitative arterial forearm flow.
authors.affiliation: Department of Nuclear Medicine of the Montreal Heart Institute, Montreal, Quebec, Canada. francois_harel@hotmail.com
authors.forename: François
authors.initials: F
authors.lastname: Harel
authors.forename: Nina
authors.initials: N
authors.lastname: Olamaei
authors.forename: Quam
authors.initials: Q
authors.lastname: Ngo
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Dupuis
authors.forename: Paul
authors.initials: P
authors.lastname: Khairy
mesh_terms: D000328:Adult; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010991:Plethysmography; D012039:Regional Blood Flow; D019265:Spectroscopy, Near-Infrared