Illuminating the black box of TNF action in tuberculous granulomas.
TNF clearly contributes to immunity to intracellular pathogens, but how it does so is incompletely understood. In this issue of Immunity, Clay et al. (2008) provide unique insights, using intravital microscopy and the zebrafish-embryo model of tuberculosis.
Miller
Elizabeth A
EA
Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.
Ernst
Joel D
JD
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D004625:Embryo, Nonmammalian; D006099:Granuloma / Q000276:immunology* / Q000378:metabolism; D018398:Homeodomain Proteins / Q000276:immunology / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D009165:Mycobacterium Infections, Nontuberculous / Q000276:immunology* / Q000382:microbiology; D019910:Mycobacterium marinum / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000378:metabolism*; D015027:Zebrafish / Q000196:embryology / Q000276:immunology / Q000378:metabolism / Q000382:microbiology
D018398:Homeodomain Proteins; D014409:Tumor Necrosis Factor-alpha