title: Initially obscure hepatotoxicity attributed to sildenafil.
abstract: We describe a patient with a hepatotoxic reaction, presenting with general malaise, severe jaundice, and pruritus. This turned out to be caused by the, at first unrevealed, use of sildenafil. The injury seems to be hepatocanalicular, characterized by a hepatocellular liver test pattern, combined with extensive cholestasis on liver biopsy. One should bare in mind that the use of sildenafil may not be readily disclosed by the patient nor his doctor.
authors.affiliation: Department of Gastroenterology, Albert Schweitzer Hospital, Dordrecht, Rotterdam, The Netherlands. frankwolfhagen@gmail.com
authors.forename: Frank H J
authors.initials: FH
authors.lastname: Wolfhagen
authors.forename: Hestia G
authors.initials: HG
authors.lastname: Vermeulen
authors.forename: Rob A
authors.initials: RA
authors.lastname: de Man
authors.forename: Wilco
authors.initials: W
authors.lastname: Lesterhuis
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects*; D010879:Piperazines / Q000009:adverse effects*; D011537:Pruritus / Q000139:chemically induced; D011687:Purines / Q000009:adverse effects; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000009:adverse effects*; D014342:Truth Disclosure
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate