Mechanistic investigation of the gold-catalyzed aerobic oxidation of aldehydes: added insight from Hammett studies and isotopic labelling experiments.
The gold-catalyzed aerobic oxidation of aldehydes proceeds through development of a partial negative charge and has a significant kinetic isotope effect (kH/kD = 2.8-2.9), which illustrates that activation of the C-H bond takes place in the rate-determining step.
Fristrup
Peter
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Center for Sustainable and Green Chemistry, Technical University of Denmark, Kemitorvet, DK-2800 Lyngby, Denmark. pf@kemi.dtu.dk
Bahn Johansen
Louise
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Hviid Christensen
Claus
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