title: Serum leptin levels are associated with cognitive function in older adults.
abstract: Recent work suggests that leptin, a circulating adipokinine hormone, might contribute to age-related cognitive decline. The present study investigated the relationship between serum leptin levels and cognitive function in older adults. Thirty-five older adults (73.69+/-6.62 years of age) without significant neurologic or psychiatric history completed a fasting blood draw and a brief neuropsychological test battery. Partial correlations adjusting for demographic and medical conditions showed that higher leptin levels were associated with poorer performance on Trail Making Test B (r = .46, p = .01). These findings indicate that serum leptin levels are negatively associated with speeded executive function in older adults without significant neurological or psychiatric conditions. The mechanisms for this relationship are unknown and require further examination. Such studies may provide key insight into the mechanisms of age-related cognitive decline and identify possible interventions.
authors.affiliation: Department of Psychology, Kent State University, Kent, OH 44242, USA. jgunstad@kent.edu
authors.forename: John
authors.initials: J
authors.lastname: Gunstad
authors.forename: Mary Beth
authors.initials: MB
authors.lastname: Spitznagel
authors.forename: Therese A
authors.initials: TA
authors.lastname: Keary
authors.forename: Ellen
authors.initials: E
authors.lastname: Glickman
authors.forename: Thomas
authors.initials: T
authors.lastname: Alexander
authors.forename: Jessica
authors.initials: J
authors.lastname: Karrer
authors.forename: Kelly
authors.initials: K
authors.lastname: Stanek
authors.forename: Lynn
authors.initials: L
authors.lastname: Reese
authors.forename: Judi
authors.initials: J
authors.lastname: Juvancic-Heltzel
mesh_terms: D000368:Aged / Q000502:physiology* / Q000523:psychology*; D003071:Cognition / Q000502:physiology*; D003627:Data Interpretation, Statistical; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D014706:Verbal Learning / Q000502:physiology
chemical_list: D007328:Insulin; D020738:Leptin