title: Discrete-Event Models of Mixed-Phenotype Plasmodium falciparum Malaria.
abstract: We extend our basic discrete-event model of Plasmodium falciparum malaria to encompass circumstances in which multiple phenotypic variants of the parasite circulate within interacting human and mosquito populations, and we compare a version in which variants behave independently to one in which they interact through shared host immune responses. Relative to the standard hypothesis of statistical independence, frequencies of mixed-phenotype infection in humans were as expected in the independent-immunity version and much less than expected in the cross-immunity version; in both versions, however, such frequencies in mosquitoes were much greater than expected.
authors.affiliation: Department of Organismic and Evolutionary Biology, and Division of Applied Sciences, Harvard University, Cambridge, Massachusetts, USA, E-mail:  infdis@deas.harvard.edu.
authors.forename: F Ellis
authors.initials: FE
authors.lastname: McKenzie
authors.forename: Roger C
authors.initials: RC
authors.lastname: Wong
authors.forename: William H
authors.initials: WH
authors.lastname: Bossert