title: Current topics of organic and biological chemistry of annonaceous acetogenins and their synthetic mimics.
abstract: Annonaceous acetogenins are a large family of natural polyketides. So far, more than 430 compounds have been isolated. Biologically, they are among the most potent of the known inhibitors of complex I (NADH-ubiquinone oxidoreductase) in mitochondrial electron transfer system. Herein, we would like to conduct an overview on the progress of the total synthesis, structural revisions, structure activity relationship for the inhibition of complex I, and action mechanism.
authors.affiliation: Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, 8304 Minami-minowa, Kami-ina, Nagano, 399-4598, Japan. makabeh@shinshu-u.ac.jp
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Makabe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Konno
authors.forename: Hideto
authors.initials: H
authors.lastname: Miyoshi
mesh_terms: D054378:Acetogenins / Q000138:chemical synthesis / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D042967:Electron Transport Complex I / Q000037:antagonists & inhibitors; D018716:Molecular Mimicry; D013329:Structure-Activity Relationship
chemical_list: D054378:Acetogenins; D000970:Antineoplastic Agents; D042967:Electron Transport Complex I