The circulation of subgenogroups B5 and C5 of enterovirus 71 in Taiwan from 2006 to 2007.
Enteroviruses (EVs) are among the most common pathogens in humans. EV71 infections have caused devastating enterovirus-associated outcomes in children globally. In this study, eleven EV71 isolates in Taiwan during 2006-2007 were selected for N-terminal VP1 gene analysis. A fragment of 403 bp on VP1 gene was sequenced and a phylogenetic analysis was performed. In addition, the full-length genome sequencing was carried out on two selected isolates. The results showed that subgenogroups of B5 and C5 had circulated and become predominant in Taiwan over the specified 2 years. Moreover, glutamic acid and threonine are found conservative at positions 43 and 58 on VP1 for genogroup B; however they are replaced by lysine and alanine, respectively, for genogroup C. To our knowledge, this is the first report describing the circulation of these two EV71 subgenogroups in Taiwan.
Huang
Yuan-Pin
YP
Research and Diagnostic Center, Centers for Disease Control, Department of Health, Taipei, Taiwan.
Lin
Tsuey-Li
TL
Kuo
Chuan-Yi
CY
Lin
Miao-Wen
MW
Yao
Ching-Yuan
CY
Liao
Hui-Wen
HW
Hsu
Li-Ching
LC
Yang
Chen-Fu
CF
Yang
Jyh-Yuan
JY
Chen
Pei-Jer
PJ
Wu
Ho-Sheng
HS
D002648:Child; D002675:Child, Preschool; D004770:Enterovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000453:epidemiology / Q000821:virology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D016415:Sequence Alignment; D013624:Taiwan / Q000453:epidemiology; D014764:Viral Proteins / Q000235:genetics
D014764:Viral Proteins