title: Tumorigenic effect of some commonly used moisturizing creams when applied topically to UVB-pretreated high-risk mice.
abstract: Irradiation of SKH-1 mice with UVB (30 mJ cm(-2)) twice a week for 20 weeks resulted in mice with a high risk of developing skin tumors over the next several months in the absence of further irradiation with UVB (high-risk mice). Topical applications of 100 mg of Dermabase, Dermovan, Eucerin Original Moisturizing Cream (Eucerin), or Vanicream once a day, 5 days a week for 17 weeks to these high-risk mice increased significantly the rate of formation of tumors and the rate of increase in tumor size per mouse. Additional studies indicated that treatment of high-risk mice with Dermabase, Dermovan, Eucerin, or Vanicream for 17 weeks increased the total number of histologically characterized tumors by 69% (average of two experiments; P<0.0001 in each experiment), 95% (P<0.0001), 24% (P<0.01), and 58% (P<0.0001), respectively. Topical applications of a specially designed Custom Blend cream to high-risk mice was not tumorigenic. The results indicate that several commercially available moisturizing creams increase the rate of formation and number of tumors when applied topically to UVB-pretreated high-risk mice. Further studies are needed to determine the effects of topical applications of moisturizing creams on sunlight-induced skin cancer in humans.
authors.affiliation: Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8020, USA.
authors.forename: Yao-Ping
authors.initials: YP
authors.lastname: Lu
authors.forename: You-Rong
authors.initials: YR
authors.lastname: Lou
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Xie
authors.forename: Qingyun
authors.initials: Q
authors.lastname: Peng
authors.forename: Weichung J
authors.initials: WJ
authors.lastname: Shih
authors.forename: Yong
authors.initials: Y
authors.lastname: Lin
authors.forename: Allan H
authors.initials: AH
authors.lastname: Conney
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004643:Emollients / Q000494:pharmacology*; D005260:Female; D008055:Lipids / Q000494:pharmacology; D051379:Mice; D008812:Mice, Hairless; D015995:Prevalence; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology*; D013472:Sunlight / Q000009:adverse effects; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014867:Water / Q000494:pharmacology
chemical_list: D004643:Emollients; D008055:Lipids; D014867:Water; C039909:eucerin