Role of polyglycine repeats in the regulation of glycogen synthase kinase activity.
Glycogen synthase kinase (GSK3) activity present in one cell is the consequence of the sum of the activities of two different proteins called GSK3alpha and GSK3beta. These isoenzymes are coded by two different genes and share an almost identical sequence at their catalytic domain, but differ in the sequence of putative regulatory regions. In this review, we propose that glycine repeats present only in GSK3alpha may result in the different cleavage of both isoenzymes by the protease calpain, a cleavage that modifies GSK3 activity.
Hernández
Felix
F
Centro de Biología Molecular "Severo Ochoa" CSIC/UAM, Fac. Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Gómez-Ramos
Alberto
A
Goñi-Oliver
Paloma
P
Avila
Jesús
J
Villanueva
Nieves
N
D002154:Calpain / Q000378:metabolism; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism*; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D010455:Peptides / Q000235:genetics / Q000502:physiology*; D020449:Repetitive Sequences, Amino Acid / Q000235:genetics
D007527:Isoenzymes; D010455:Peptides; C011080:polyglycine; D038362:Glycogen Synthase Kinase 3; D002154:Calpain