111/121 diplotype of Calpain-10 is associated with the risk of polycystic ovary syndrome in Korean women.
We investigated whether the CAPN-10 polymorphism UCSNP-43, -19, and -63 contribute, either individually or as haplotype/diplotype, to the susceptibility of polycystic ovary syndrome (PCOS) or related quantitative traits in Korean women. Our data showed that 111 haplotype and 111/121 and 111/111 diplotypes in the CAPN-10 gene were associated with a significantly increased risk of PCOS, and 112 haplotype and 121/121 and 112/122 diplotypes were associated with decreased risk of PCOS in the Korean population.
Lee
Ji Young
JY
Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Korea.
Lee
Woon Jeong
WJ
Hur
Sung Eun
SE
Lee
Chul Min
CM
Sung
Yeon-Ah
YA
Chung
Hye Won
HW
D000328:Adult; D002154:Calpain / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D015994:Incidence; D007723:Korea / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
D002154:Calpain; C415197:calpain 10