title: Interaction of human serum albumin and its clinically relevant modification with oligoribonucleotides.
abstract: Human serum albumin (HSA) was shown to mediate oligoribonucleotide cleavage. Nonenzymatic glycation of HSA decreased the ribonuclease-like activity of the protein. According to (31)P NMR data, both native and glycated albumins induced hydrolysis of RNA molecule through 2',3'-cyclophosphate intermediates. A feasible mechanism of RNA hydrolysis by native albumin and its clinically relevant modification was discussed.
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 8 Lavrentyev Ave., 630090 Novosibirsk, Russia.
authors.forename: Yuliya V
authors.initials: YV
authors.lastname: Gerasimova
authors.forename: Irina A
authors.initials: IA
authors.lastname: Erchenko
authors.forename: Makhmut M
authors.initials: MM
authors.lastname: Shakirov
authors.forename: Tatyana S
authors.initials: TS
authors.lastname: Godovikova
mesh_terms: D001671:Biochemistry / Q000379:methods; D002852:Chromatography, Ion Exchange / Q000379:methods; D006801:Humans; D006868:Hydrolysis; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D009696:Nucleic Acids / Q000737:chemistry; D009843:Oligoribonucleotides / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry; D011485:Protein Binding; D012313:RNA / Q000737:chemistry; D012709:Serum Albumin / Q000737:chemistry* / Q000378:metabolism
chemical_list: D008024:Ligands; D009696:Nucleic Acids; D009843:Oligoribonucleotides; D010710:Phosphates; D012709:Serum Albumin; D012313:RNA