title: Sneddon-Wilkinson disease treated with etanercept: report of two cases.
abstract: Sneddon-Wilkinson disease (SWD), also known as subcorneal pustular dermatosis, is a rare, chronic eruption that is often difficult to treat, particularly in patients who do not respond to or cannot tolerate dapsone. Few case reports exist of patients with SWD treated with antitumour necrosis factor-alpha therapy. We report two patients with SWD refractory to numerous treatments, who responded to etanercept (in combination with low-dose acitretin in one case).
authors.affiliation: Department of Internal Medicine, Division of Dermatology, Washington University School of Medicine, St Louis, MO 63110, USA. dberk@im.wustl.edu
authors.forename: D R
authors.initials: DR
authors.lastname: Berk
authors.forename: M A
authors.initials: MA
authors.lastname: Hurt
authors.forename: C
authors.initials: C
authors.lastname: Mann
authors.forename: D
authors.initials: D
authors.lastname: Sheinbein
mesh_terms: D000328:Adult; D000368:Aged; D003879:Dermatologic Agents / Q000627:therapeutic use*; D000068800:Etanercept; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D003879:Dermatologic Agents; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D000068800:Etanercept