title: Role of polyglycine repeats in the regulation of glycogen synthase kinase activity.
abstract: Glycogen synthase kinase (GSK3) activity present in one cell is the consequence of the sum of the activities of two different proteins called GSK3alpha and GSK3beta. These isoenzymes are coded by two different genes and share an almost identical sequence at their catalytic domain, but differ in the sequence of putative regulatory regions. In this review, we propose that glycine repeats present only in GSK3alpha may result in the different cleavage of both isoenzymes by the protease calpain, a cleavage that modifies GSK3 activity.
authors.affiliation: Centro de Biología Molecular "Severo Ochoa" CSIC/UAM, Fac. Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Felix
authors.initials: F
authors.lastname: Hernández
authors.forename: Alberto
authors.initials: A
authors.lastname: Gómez-Ramos
authors.forename: Paloma
authors.initials: P
authors.lastname: Goñi-Oliver
authors.forename: Jesús
authors.initials: J
authors.lastname: Avila
authors.forename: Nieves
authors.initials: N
authors.lastname: Villanueva
mesh_terms: D002154:Calpain / Q000378:metabolism; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism*; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D010455:Peptides / Q000235:genetics / Q000502:physiology*; D020449:Repetitive Sequences, Amino Acid / Q000235:genetics
chemical_list: D007527:Isoenzymes; D010455:Peptides; C011080:polyglycine; D038362:Glycogen Synthase Kinase 3; D002154:Calpain