title: Preparation of highly photosensitizing liposomes with fullerene-doped lipid bilayer using dispersion-controllable molecular exchange reactions.
abstract: Fullerene-containing liposomes with high photosensitization ability were prepared. Disaggregated fullerenes were efficiently injected into the bilayer of liposomes by a phototriggered molecular exchange reaction. These liposomes showed far higher photoreactivity than liposomes thermally produced by heating and microwave irradiation. This result indicates that control of self-aggregation of fullerene leads to a high quantum yield for the photoreaction because of the suppression of self-quenching of photoexcited fullerenes.
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma 630-0192, Japan. aikeda@ms.naist.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ikeda
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Sue
authors.forename: Motofusa
authors.initials: M
authors.lastname: Akiyama
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Fujioka
authors.forename: Tamami
authors.initials: T
authors.lastname: Shigematsu
authors.forename: Yuki
authors.initials: Y
authors.lastname: Doi
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kikuchi
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Konishi
authors.forename: Riichiro
authors.initials: R
authors.lastname: Nakajima
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D037741:Fullerenes / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008081:Liposomes / Q000138:chemical synthesis* / Q000737:chemistry; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003505:Cyclodextrins; D004337:Drug Carriers; D037741:Fullerenes; D008051:Lipid Bilayers; D008081:Liposomes; D017319:Photosensitizing Agents; C069837:fullerene C60