title: Age-related clinical, serological, and histopathological features of celiac disease.
abstract: BACKGROUND
  Celiac disease (CD) is a common disorder in children and adults. However, limited data are available when comparing differences between both populations.
  
  
  OBJECTIVE
  To prospectively evaluate and compare the clinical and histological features present at diagnosis in a cohort of celiac children and adults.
  
  
  METHODS
  Consecutive new cases diagnosed between 2000 and 2006 were prospectively included (66 children and 54 adults). The clinical spectrum was categorized in two groups: (a) typical (malabsorption, chronic diarrhea, or failure to thrive) and (b) oligosymptomatic (abdominal pain, anemia, hypertransaminasemia, or screening in risk groups or in relatives). The histological results were divided into mild (i.e., Marsh I, II, and IIIA) and severe (i.e., Marsh IIIB, IIIC). In all cases, the human antitissue transglutaminase IgA antibodies (TTGA) were determined.
  
  
  RESULTS
  Overall, a female/male ratio (2.6:1) was observed. This ratio was significantly higher in adults (5.7:1) than in children (1.6:1) (P= 0.009). Typical symptoms were present in 62.5% children versus 31% adults (P= 0.01). The average time to diagnosis after the appearance of symptoms was 7.6 months for children and 90 months for adults (P < 0.001). TTGA levels were higher in children and correlated with age (P < 0.001) and with the degree of villous atrophy (P < 0.001). Histological analysis revealed a marked atrophy in 86% children versus 52% adults (P < 0.001). The degree of villous atrophy was inversely correlated with age (P < 0.001). Classic symptoms were also associated with more severe villous atrophy.
  
  
  CONCLUSIONS
  At initial diagnosis, CD shows age-related differences, which consist of more evident clinical and histological features in children. Furthermore, IgA TTGA levels correlate both with the degree of villous atrophy and with the patient's age.
authors.affiliation: Department of Gastroenterology, Instituto de Biomedicina, University of León, León, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Vivas
authors.forename: Jose M
authors.initials: JM
authors.lastname: Ruiz de Morales
authors.forename: Marisa
authors.initials: M
authors.lastname: Fernandez
authors.forename: Mercedes
authors.initials: M
authors.lastname: Hernando
authors.forename: Blanca
authors.initials: B
authors.lastname: Herrero
authors.forename: Javier
authors.initials: J
authors.lastname: Casqueiro
authors.forename: Santiago
authors.initials: S
authors.lastname: Gutierrez
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D002446:Celiac Disease / Q000097:blood / Q000145:classification* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D011503:Transglutaminases / Q000097:blood
chemical_list: D015415:Biomarkers; D011503:Transglutaminases