Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system.
Sphingolipids were once regarded as inert structural components of cell membranes. Now these metabolites are generally believed to be important bioactive molecules that control a wide repertoire of cellular processes such as proliferation and survival of cells. Along with these ubiquitous cell functions observed in many peripheral tissues sphingolipid metabolites, especially sphingosine 1-phosphate, exert important neuron-specific functions such as regulation of neurotransmitter release. This review summarizes physiological and pathological roles of sphingolipid metabolites emphasizing the role of sphingosine 1-phosphate in the central nervous system.
Okada
Taro
T
Division of Biochemistry, Department of Biochemistry/Molecular Biology, Kobe University Graduate School of Medicine, Kobe, 650-0017, Japan.
Kajimoto
Taketoshi
T
Jahangeer
Saleem
S
Nakamura
Shun-ichi
S
D000818:Animals; D017209:Apoptosis; D002470:Cell Survival / Q000502:physiology; D002490:Central Nervous System / Q000378:metabolism*; D005089:Exocytosis; D008246:Lysophospholipids / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism; D000099157:Sphingosine Kinase
D008246:Lysophospholipids; D018377:Neurotransmitter Agents; D017853:Phosphotransferases (Alcohol Group Acceptor); D013110:Sphingosine; D000099157:Sphingosine Kinase; C060506:sphingosine 1-phosphate