title: Exploring evolution in Ceboidea (Platyrrhini, primates) by Williams-Beuren probe (HSA 7q11.23) chromosome mapping.
abstract: The ancestral platyrrhine karyotype was characterised by a syntenic association of human 5 and a small segment of human 7 orthologues. This large syntenic association has undergone numerous rearrangements in various phylogenetic lines. We used a locus-specific molecular cytogenetic approach to study the chromosomal evolution of the human 7q11.23 orthologous sequences (William-Beuren syndrome, WS) in various Ceboidea (Platyrrhini) species. The fluorescent in situ hybridisation of the WS probe revealed a two-way pattern of chromosomal organisation that suggests various evolutionary scenarios. The first pattern (seen in Callimico and Saimiri) includes a fairly simple disruption of the 7/5 syntenic association by a chromosome fission. The second pattern (seen in Atelinae, Alouattinae and in Callicebus) is characterised by an increasing complexity in the 7/5 association as a consequence of a series of inversions and translocations resulting in different syntenic associations. These data support recent proposals for phylogenomic groupings of New World monkeys. The study also illustrates how single-locus probe hybridisations can reveal intrachromosomal rearrangements.
authors.affiliation: Dipartimento di Biologia animale G Reverberi, Università degli Studi di Palermo, Palermo, Italia.
authors.forename: Barbara
authors.initials: B
authors.lastname: Picone
authors.forename: Francesca
authors.initials: F
authors.lastname: Dumas
authors.forename: Roscoe
authors.initials: R
authors.lastname: Stanyon
authors.forename: Antonella
authors.initials: A
authors.lastname: Lannino
authors.forename: Francesca
authors.initials: F
authors.lastname: Bigoni
authors.forename: Orsola
authors.initials: O
authors.lastname: Privitera
authors.forename: Luca
authors.initials: L
authors.lastname: Sineo
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002427:Cebidae / Q000145:classification / Q000235:genetics*; D002874:Chromosome Mapping