Information theory provides a comprehensive framework for the evaluation of protein structure predictions.
Protein structure prediction has a number of important ad hoc similarity measures for evaluating predictions, but would benefit from a measure that is able to provide a common framework for a broad range of comparisons. Here we show that a mutual information-like measure can provide a comprehensive framework for evaluating protein structure prediction of all types. We discuss the concept of information, its application to secondary structure, and the obstacle to applying it to 3D structure. On the basis of the insights from the secondary structure case, we present an approach to work around the 3D difficulties, and develop a method to measure the mutual information provided by a 3D structure prediction. We integrate the evaluation of all types of protein structure prediction into a single framework, and compare the amount of information provided by various prediction methods, including secondary structure prediction. Within this broadened framework, the idea that structure is better preserved than sequence during evolution is evaluated quantitatively for the globin family. A nearly perfect sequence match in the globin family corresponds to about 300 bits of information, whereas a nearly perfect structural match for the same two proteins corresponds to about 2500 bits of information, where bits of information describes the probability of obtaining a match of similar closeness by chance. Mutual information provides both a theoretical basis for evaluating structure similarity and an explanatory surround for existing similarity measures.
Swanson
Rosemarie
R
Department of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, Texas 77843, USA. rosmar@tamu.edu
Vannucci
Marina
M
Tsai
Jerry W
JW
D030562:Databases, Protein; D019277:Entropy; D007257:Information Theory; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry; D020539:Sequence Analysis, Protein; D013329:Structure-Activity Relationship
D011506:Proteins