The molecular mechanism of mitochondrial fusion.
This review is focused on mitochondrial membrane fusion, which is a highly conserved process from yeast to human cells. We present observations from both yeast and mammalian cells that have provided insights into the mechanism of mitochondrial fusion and speculate on how the key players, which are dynamin-related GTPases do the work of membrane tethering and fusion.
Hoppins
Suzanne
S
Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA.
Nunnari
Jodi
J
D000818:Animals; D034281:Dynamins / Q000378:metabolism; D006801:Humans; D008561:Membrane Fusion / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism; D008954:Models, Biological; D054875:Ubiquitination / Q000502:physiology
D024101:Mitochondrial Proteins; D034281:Dynamins