title: 2008: A MyD88 O, DC.
abstract: In this issue of Immunity, Hou et al. (2008) describe the generation of mice that selectively lack the adaptor protein MyD88 in dendritic cells (DCs). These mice demonstrate that the requirement for Toll-like receptor (TLR) signaling in DCs is dependent on the physical form of the TLR ligand.
authors.affiliation: Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA. bpulend@rmy.emory.edu.
authors.forename: Bali
authors.initials: B
authors.lastname: Pulendran
authors.forename: Weiping
authors.initials: W
authors.lastname: Cao
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood*; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology; D008024:Ligands; D051379:Mice; D008817:Mice, Mutant Strains; D053594:Myeloid Differentiation Factor 88 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism*
chemical_list: D016207:Cytokines; D005229:Fatty Acids, Monounsaturated; D008024:Ligands; C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88; D009838:Oligodeoxyribonucleotides; D000644:Quaternary Ammonium Compounds; D051193:Toll-Like Receptors; C070046:1,2-dioleoyloxy-3-(trimethylammonium)propane