[Molecular medicine in thyroid surgery].
Cancer originates from a single cell which, through the acquisition of mutations in genes for key growth and survival factors, undergoes clonal expansion. Study of the genome allowed the detection of genes whose mutation is involved in tumour formation. In detail, in most thyroid neoplasms we are now able to identify the genes which cause cancer initiation. Moreover, correlations between mutations and clinico-pathological features of the tumours have been revealed. Thus, the genetic study of tumours is not anymore only a scientific curiosity, but a useful tool for the formulation of the more efficacious therapeutic and follow-up strategies. In this review we will summarize the more recent molecular medicine acquisitions in the thyroid cancer field and will describe their present and eventually future impact on the activity of the endocrine surgeon.
Moretti
Sonia
S
Dipartimento di Medicina Interna, Centro di Riferimento Regionale per l'Endocrinochirurgia, Università degli Studi di Perugia, Perugia.
Barbi
Flavia
F
Tavano
Maria
M
Calzolari
Filippo
F
Misso
Claudia
C
Lucchini
Roberta
R
Monacelli
Massimo
M
D'Ajello
Michele
M
Puxeddu
Efisio
E
Avenia
Nicola
N
D018276:Carcinoma, Medullary / Q000235:genetics / Q000601:surgery; D002291:Carcinoma, Papillary / Q000235:genetics; D006801:Humans; D018813:Multiple Endocrine Neoplasia Type 2a / Q000235:genetics; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000601:surgery*
D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf