title: Relationship between free-radical lipid oxidation and efficiency of coronary angioplasty in coronary patients.
abstract: Low-dose (250 mg daily) oral probucol produces a significant antioxidant effect in coronary patients: increases activity of glutathione peroxidase (enzyme utilizing lipoperoxides) and reduces the content of free-radical oxidation products in the blood. Probucol therapy for 7 days before and for 6 months after coronary angioplasty significantly reduces the severity of coronary artery stenosis.
authors.affiliation: A. L. Myasnikov Institute of Cardiology, Russian Cardiological Center, Russian Ministry of Health, Moscow. akam67@rambler.tu
authors.forename: A I
authors.initials: AI
authors.lastname: Kaminnyi
authors.forename: V Z
authors.initials: VZ
authors.lastname: Lankin
authors.forename: E I
authors.initials: EI
authors.lastname: Perepelitsa
authors.forename: G G
authors.initials: GG
authors.lastname: Konovalova
authors.forename: A N
authors.initials: AN
authors.lastname: Samko
authors.forename: A K
authors.initials: AK
authors.lastname: Tikhaze
authors.forename: V V
authors.initials: VV
authors.lastname: Kukharchuk
authors.forename: Yu N
authors.initials: YN
authors.lastname: Belenkov
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy; D005609:Free Radicals / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011341:Probucol / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D005979:Glutathione Peroxidase; D011341:Probucol