title: Assessment of cardiac output in liver transplantation recipients.
abstract: BACKGROUND
  Liver cirrhosis causes peculiar systemic hemodynamics, and accurate evaluation of systemic hemodynamic state is important for cirrhotic recipients who underwent living donor liver transplantation (LDLT). We investigated the clinical advantages of a novel non-invasive method for measuring systemic hemodynamic parameters using indocyanine green (ICG).
  
  
  METHODS
  Twenty-eight LDLT recipients were evaluated. Simultaneous measurements of cardiac output (CO) using Swan-Ganz catheters and pulse dye densitometry (PDD) were performed every 12 hours after LDLT. A total of 155 sets of simultaneous CO measurements were obtained.
  
  
  RESULTS
  The CO values obtained by PDD correlated well with those obtained by the invasive catheter technique. In addition, none of the recipients developed any side-effects, and we verified the safety of repeated ICG injections. ICG is safe, even for repeated use over time in the same recipient. Moreover, PDD can measure the blood volume (BV).
  
  
  CONCLUSIONS
  Since the cirrhotic systemic hemodynamics characterized by high CO and large BV remains, even after LDLT, the ability to measure CO and BV in a non-invasive, simple and real-time manner using PDD has advantages for cirrhotic LDLT recipients.
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery and Transplantation, Kyoto University Hospital, Sakyo-ku, Kyoto, 606-8507, Japan. horit@kuhp.kyoto-u.ac.jp
authors.forename: Tomohide
authors.initials: T
authors.lastname: Hori
authors.forename: Chiduru
authors.initials: C
authors.lastname: Yamamoto
authors.forename: Shintaro
authors.initials: S
authors.lastname: Yagi
authors.forename: Taku
authors.initials: T
authors.lastname: Iida
authors.forename: Kentaro
authors.initials: K
authors.lastname: Taniguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yamakado
authors.forename: Yukinobu
authors.initials: Y
authors.lastname: Hori
authors.forename: Kan
authors.initials: K
authors.lastname: Takeda
authors.forename: Kazuo
authors.initials: K
authors.lastname: Maruyama
authors.forename: Shinji
authors.initials: S
authors.lastname: Uemoto
mesh_terms: D000328:Adult; D001810:Blood Volume; D002302:Cardiac Output; D002407:Catheterization, Swan-Ganz; D004396:Coloring Agents / Q000008:administration & dosage; D003720:Densitometry; D004395:Dye Dilution Technique; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage; D007275:Injections, Intravenous; D008103:Liver Cirrhosis / Q000503:physiopathology / Q000601:surgery*; D016031:Liver Transplantation; D019520:Living Donors; D011237:Predictive Value of Tests; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green