title: Distal pancreatectomy is not associated with increased perioperative morbidity when performed as part of a multivisceral resection.
abstract: OBJECTIVE
  To evaluate the indications for and the outcomes from distal pancreatectomy.
  
  
  METHODS
  Retrospective chart review of 171 patients who underwent distal pancreatectomy at Brigham and Women's Hospital between January 1996 and August 2005.
  
  
  RESULTS
  Nearly one-third of distal pancreatectomies were performed as part of an en bloc resection for a contiguous or metastatic tumor. Fifty-six percent of the patients underwent a standard distal pancreatectomy +/- splenectomy (group 1), whereas 44% of distal pancreatic resections included additional organs or contiguous intraperitoneal or retroperitoneal tumor (group 2). The overall post-operative complication rate was 37%; the most common complication was pancreatic duct leak (23%). When compared to patients undergoing standard distal pancreatectomy, those with a more extensive resection including multiple viscera and/or metastatic or contiguous tumor resection had no significant difference in overall complication rate (35% v. 39%, p = 0.75), leak rate (25% v. 20%, p = 0.47), new-onset insulin-dependent diabetes mellitus (3% v. 4%, p = 1.0), and mortality (2% v. 4%, p = 0.656).
  
  
  CONCLUSIONS
  This series includes a large number of patients in whom distal pancreatectomy was performed as part of a multivisceral resection or with en bloc resection of contiguous tumor. Complications were no different in these patients when compared to patients undergoing straightforward distal pancreatectomy.
authors.affiliation: Brigham and Women's Hospital, Department of Surgery, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Irani
authors.forename: Stanley W
authors.initials: SW
authors.lastname: Ashley
authors.forename: David C
authors.initials: DC
authors.lastname: Brooks
authors.forename: Robert T
authors.initials: RT
authors.lastname: Osteen
authors.forename: Chandrajit P
authors.initials: CP
authors.lastname: Raut
authors.forename: Sara
authors.initials: S
authors.lastname: Russell
authors.forename: Richard S
authors.initials: RS
authors.lastname: Swanson
authors.forename: Edward E
authors.initials: EE
authors.lastname: Whang
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Zinner
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Clancy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods*; D010182:Pancreatic Diseases / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications; D012189:Retrospective Studies; D016896:Treatment Outcome