title: "HIT on Trousseau" double trouble: acquired coagulopathy with femoral artery thrombosis.
abstract: Trousseau Syndrome is a paraneoplastic procoagulant phenomenon. Heparin-induced thrombocytopenia (HIT) is a rare complication of anticoagulation with heparin. To our knowledge, the coincidence of the two has not been reported so far. We report a case of an acute thrombosis of the left femoral artery and distal leg arteries in a patient with an otherwise normal cardiovascular status. Endovascular revascularization attempts using mechanical rotational thrombectomy catheter, aspiration and local thrombolysis were unsuccessful. Progressive coagulation along the intra-arterial catheter was seen. Surgical thrombectomy of the femoral-pedal axis was successful, but the patient developed an immune-mediated HIT postoperatively. An adenocarcinoma of the colon was the likely cause for the initial arterial thrombosis, and probably adversely affected endovascular revascularization attempts. Subsequent HIT with microvascular thrombosis worsened ischemic damage leading to a below knee-amputation, despite patent large vessels. Compared to venous thrombosis, arterial thrombosis is a rare manifestation of Trousseau syndrome. The coincidence of it with HIT is even rarer. There may be a causal relationship between the two.
authors.affiliation: Division of Angiology and Vascular Surgery, Cardiovascular Department, Inselspital Bern, University Hospital and University of Bern, Switzerland. cornelius.warncke@insel.ch
authors.forename: C
authors.initials: C
authors.lastname: Warncke
authors.forename: L
authors.initials: L
authors.lastname: Alberio
authors.forename: H
authors.initials: H
authors.lastname: Savolainen
authors.forename: R
authors.initials: R
authors.lastname: von Allmen
authors.forename: I
authors.initials: I
authors.lastname: Baumgartner
authors.forename: M
authors.initials: M
authors.lastname: Husmann
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000671:Amputation, Surgical; D000925:Anticoagulants / Q000009:adverse effects*; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D003082:Colectomy; D003110:Colonic Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D003113:Colonoscopy; D017128:Embolectomy; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000601:surgery; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D011859:Radiography; D013396:Suction; D017131:Thrombectomy; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000628:therapy; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006493:Heparin