Advanced microarray analysis highlights modified neuro-immune signaling in nucleated blood cells from Parkinson's disease patients.
Laboratory tests for Parkinson's disease (PD) were recently extended to microarray analyses of nucleated blood cells. Here, we report the use of statistical and gene ontology tools to re-examine these microarray data. Distribution plots and PCA mapping enabled removal of several outliers out of the 105 analyzed PD and control samples, which improved the discriminative power for PD blood cells compared to healthy and neurological disease controls. Combined with gene ontology tests, our findings point at neuro-immune signaling-related transcripts as distinctly expressed early in PD progress and call for exploiting microarray tests also for follow-up of PD treatment efficacy.
Soreq
Lilach
L
Department of Physiology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Israel
Zvi
Z
Bergman
Hagai
H
Soreq
Hermona
H
D004900:Erythroblasts / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D046228:Microarray Analysis / Q000379:methods*; D010300:Parkinson Disease / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology*; D015398:Signal Transduction / Q000235:genetics*