Cytotoxic lanostanoid triterpenes from Ganoderma lucidum.
Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic acid (1), and 12beta-acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8-25 microm.
Guan
Shu-Hong
SH
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Shanghai Research Center for TCM Modernization, Chinese Academy of Sciences, Shanghai, China.
Xia
Jia-Meng
JM
Yang
Min
M
Wang
Xiao-Ming
XM
Liu
Xuan
X
Guo
De-An
DA
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D020940:Reishi / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
C532704:12beta-acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20E-diene-26-oic acid; C532703:23S-hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic acid; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes