Nanofibrous glass tailored with apatite-fibronectin interface for bone cell stimulation.
Exploring a material with smart and biomimetic interface has great potential in the biomaterials and tissue engineering field. This paper reports a novel nanofibrous bone matrix that was developed to retain a cell-stimulating and bone-mimetic biointerface. The bone mineral, apatite, and the cell adhesive protein, fibronectin (FN), were hybridized on the interface of a bioactive glass nanofibrous mesh, through the dissolution-and-reprecipitation process. The hybridized nanofibrous mesh showed significant improvement in the initial responses of the bone-derived cells. It is believed that this biomimetic and cell-stimulating nanofibrous mesh can be used as a potential bone regeneration matrix.
Kim
Hae-Won
HW
Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan, 330-714, Korea.
Lee
Hae-Hyoung
HH
Knowles
Jonathan C
JC
D001031:Apatites / Q000737:chemistry*; D001842:Bone and Bones / Q000166:cytology*; D005353:Fibronectins / Q000737:chemistry*; D005898:Glass; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures
D001031:Apatites; D005353:Fibronectins