Gemmacin B: bringing diversity back into focus.
Through the synthesis of a focused library and SAR investigations, a more potent analogue of gemmacin (discovered in a previous diversity-oriented synthesis (DOS) campaign), gemmacin B, was discovered.
Robinson
Anna
A
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.
Thomas
Gemma L
GL
Spandl
Richard J
RJ
Welch
Martin
M
Spring
David R
DR
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000737:chemistry* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D013440:Sulfides; C532654:gemmacin B