[Changes of serum gastrin, plasma motilin, and gastric motility in gastric cancer patients after subtotal gastrectomy].
OBJECTIVE
To study the change of the serum gastrin (GAS) and plasma motilin (MTL) levels as well as the gastric motility in gastric cancer patients after subtotal gastrectomy.


METHODS
We used radioimmunoassay method to detect the levels of serum GAS and plasma MTL in 39 healthy volunteers (control group) and 39 gastric cancer patients before and after gastrectomy (gastric cancer group). Electrogastrography (EGG) was measured at the same time points.


RESULTS
The levels of serum GAS and plasma MTL in gastric cancer group before operation were significantly higher than those in control group (P = 0.000), and the levels of serum GAS and plasma MTL in gastric cancer stage II patients were also significantly higher than those in stage III patients (P <0.05). The levels of serum GAS and plasma MTL in gastric cancer group significantly decreased on the first post-operative day (P = 0.000), but returned to the pre-operative levels on the seventh post-operative day. The incidence of the abnormity of gastric motility in gastric cancer group on the seventh post-operative day was significantly higher than the pre-operation incidence (89.7% vs. 43.6%; chi2 = 18.692, P <0.01).


CONCLUSIONS
The levels of serum GAS and plasma MTL transiently decreased in gastric cancer patients. Subtotal gastrectomy could affect the gastric motility in gastric cancer patients.
Zhang
Qun
Q
Department of General Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Yu
Jian-Chun
JC
Kang
Wei-Ming
WM
Ke
Mei-Yun
MY
Qian
Jia-Ming
JM
D000328:Adult; D000368:Aged; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D005755:Gastrins / Q000097:blood*; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009037:Motilin / Q000097:blood*; D011863:Radioimmunoassay; D013274:Stomach Neoplasms / Q000097:blood* / Q000601:surgery*; D016896:Treatment Outcome
D005755:Gastrins; D009037:Motilin