The role of the cerebellum in the pathophysiology and treatment of neuropsychiatric disorders: a review.
The cerebellum has traditionally been looked upon as a brain area primarily involved in motor behaviour. The last decade has however heralded the cerebellum as a brain region of renewed interest for neuropsychiatric disorders. This renewed interest is fuelled by new insights obtained from neuroanatomical research, modern functional neuroimaging and transcranial magnetic stimulation studies. In this review, evidence in support of cerebellar involvement in neuropsychiatric disorders will be presented. In addition, transcranial magnetic stimulation will be introduced as a novel way to study cerebellar contributions to the pathophysiology of psychiatric disorders. In conclusion, a new functional concept of the cerebellum as more than simply a brain area regulating motor control appears mandatory and the involvement of the cerebellum should be considered when studying the neurological basis of neuropsychiatric disorders.
Hoppenbrouwers
Sylco S
SS
Department of Experimental Psychology, Utrecht University, The Netherlands.
Schutter
Dennis J L G
DJ
Fitzgerald
Paul B
PB
Chen
Robert
R
Daskalakis
Zafiris J
ZJ
D000818:Animals; D002531:Cerebellum / Q000002:abnormalities / Q000503:physiopathology*; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology*; D006801:Humans; D001523:Mental Disorders / Q000150:complications / Q000473:pathology* / Q000628:therapy*