title: Activated recombinant protein C in septic shock early after liver transplantation: a case report.
abstract: Severe infectious diseases after liver transplant are associated with high risk of multiorgan failure and mortality. Septic shock is difficult to manage in this setting since it is often unresponsive to conventional aggressive therapy. Adjuvant therapies have been proposed in association with full combination treatment to sustain the failing organs and improve outcomes in severe sepsis. Recombinant human activated protein C drotrecogin alfa, Xigris) has been occasionally administered to treat posttransplant sepsis to modulate and downregulate the complex network of inflammatory and coagulopathic processes. Herein we have reported on a patient who was given drotrecogin alfa 15 days following liver transplant for acute septic shock originating from a nosocomially acquired pneumonia. Recombinant activated drotrecogin alfa, associated with conventional aggressive treatment, was efficacious to revert the life-threatening "slippery slope" of vasoplegia and uncontrolled diffuse inflammation.
authors.affiliation: Department of Pharmacology and Anesthesiology, University Hospital of Padova, Padova, Italy. paolofeltracco@inwind.it
authors.forename: P
authors.initials: P
authors.lastname: Feltracco
authors.forename: A
authors.initials: A
authors.lastname: Bortolato
authors.forename: S
authors.initials: S
authors.lastname: Rizzi
authors.forename: S
authors.initials: S
authors.lastname: Barbieri
authors.forename: M
authors.initials: M
authors.lastname: Furnari
authors.forename: E
authors.initials: E
authors.lastname: Serra
authors.forename: M
authors.initials: M
authors.lastname: Milevoj
authors.forename: C
authors.initials: C
authors.lastname: Ori
mesh_terms: D003428:Cross Infection / Q000139:chemically induced; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000150:complications; D011183:Postoperative Complications / Q000188:drug therapy; D011486:Protein C / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012772:Shock, Septic / Q000188:drug therapy*
chemical_list: D005343:Fibrinolytic Agents; D011486:Protein C; D011994:Recombinant Proteins; C421124:drotrecogin alfa activated