Preparation of highly photosensitizing liposomes with fullerene-doped lipid bilayer using dispersion-controllable molecular exchange reactions.
Fullerene-containing liposomes with high photosensitization ability were prepared. Disaggregated fullerenes were efficiently injected into the bilayer of liposomes by a phototriggered molecular exchange reaction. These liposomes showed far higher photoreactivity than liposomes thermally produced by heating and microwave irradiation. This result indicates that control of self-aggregation of fullerene leads to a high quantum yield for the photoreaction because of the suppression of self-quenching of photoexcited fullerenes.
Ikeda
Atsushi
A
Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma 630-0192, Japan. aikeda@ms.naist.jp
Sue
Tatsuya
T
Akiyama
Motofusa
M
Fujioka
Katsuyoshi
K
Shigematsu
Tamami
T
Doi
Yuki
Y
Kikuchi
Jun-ichi
J
Konishi
Toshifumi
T
Nakajima
Riichiro
R
D003505:Cyclodextrins / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D037741:Fullerenes / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008081:Liposomes / Q000138:chemical synthesis* / Q000737:chemistry; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry
D003505:Cyclodextrins; D004337:Drug Carriers; D037741:Fullerenes; D008051:Lipid Bilayers; D008081:Liposomes; D017319:Photosensitizing Agents; C069837:fullerene C60