title: Essential oil from leaves of Cinnamomum osmophloeum acts as a xanthine oxidase inhibitor and reduces the serum uric acid levels in oxonate-induced mice.
abstract: The xanthine oxidase (XOD) inhibitory activity and anti-hyperuricemia effect in mice of Cinnamomum osmophloeum, which is an endemic tree in Taiwan, were evaluated in this study. The results demonstrated that the essential oil of C. osmophloeum leaves presented the strongest XOD inhibition activity (IC(50)=16.3 μg/ml); however, no significant XOD inhibition activities were found in ethanolic and hot water extracts. Furthermore, among the main compounds of essential oil, the cinnamaldehyde exhibited the potent XOD inhibition activity with an IC(50)=8.4 μg/ml. Besides, the reducing serum uric acid levels in oxonate-induced mice by cinnamaldehyde were further investigated. The hyperuricemic mice were oral administrated cinnamaldehyde at a dosage of 150 mg/kg, the uric acid value in serum was reduced from 5.25±0.63 to 2.10±0.04 mg/dl, the levels of serum uric acid in mice was lowered down by 84.48% as compared to the hyperuricemic control group. Based on the results obtained in this study, cinnamaldehyde may be a potential lead compound for developing the pharmaceutic for anti-hyperuricemia agent.
authors.affiliation: Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan. taiwanfir@dragon.nchu.edu.tw
authors.forename: S Y
authors.initials: SY
authors.lastname: Wang
authors.forename: C W
authors.initials: CW
authors.lastname: Yang
authors.forename: J W
authors.initials: JW
authors.lastname: Liao
authors.forename: W W
authors.initials: WW
authors.lastname: Zhen
authors.forename: F H
authors.initials: FH
authors.lastname: Chu
authors.forename: S T
authors.initials: ST
authors.lastname: Chang
mesh_terms: D000171:Acrolein / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D000284:Administration, Oral; D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D027424:Cinnamomum / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006074:Gout Suppressants / Q000494:pharmacology; D033461:Hyperuricemia / Q000139:chemically induced / Q000188:drug therapy*; D020128:Inhibitory Concentration 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010094:Oxonic Acid / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D013624:Taiwan; D014527:Uric Acid / Q000097:blood*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D006074:Gout Suppressants; D009822:Oils, Volatile; D010936:Plant Extracts; D010938:Plant Oils; D014527:Uric Acid; C489337:potassium oxonate; D010094:Oxonic Acid; D000493:Allopurinol; D000171:Acrolein; D014969:Xanthine Oxidase; C012843:cinnamaldehyde