title: Anxiety and depression after coronary artery bypass graft surgery: most get better, some get worse.
abstract: BACKGROUND
  To target interventions, patients at risk for poor outcomes after a cardiac event need to be identified. We investigated trajectories of anxiety and depression after coronary artery bypass graft surgery (CABGS) and identified patients at risk of persistent or worsening anxiety and depression.
  
  
  METHODS
  A consecutive sample of 184 patients on the waiting list for CABGS at The Royal Melbourne Hospital completed self-report questionnaires before surgery, and at 2 and 6 months postsurgery. Anxiety and depression were measured using the Hospital Anxiety and Depression Scale. Growth mixture modelling identified trajectories of anxiety and depression.
  
  
  RESULTS
  Two possible trajectories emerged for anxiety, whereas three trajectories emerged for depression. Most patients (92%) followed a trajectory of minor presurgical anxiety that remitted in 6 months after CABGS, with the remainder (8%) following a trajectory of major anxiety that remitted in the same period. Minor remitted depression was also common (72% patients). Two less common depression trajectories indicated worsening or unresolved depression. One trajectory began with major presurgical depression that partially remitted by 6 months (14% patients) and the other began with minor presurgical depression that worsened by 6 months (14% patients). Unpartnered patients, smokers, those with presurgical anxiety, high cholesterol, angina, more severe disease or having repeat CABGS were at increased risk for a poor depression trajectory.
  
  
  CONCLUSIONS
  Although initial anxiety and depression resolved or lessened for most patients, some patients experienced persistent or worsening depression after CABGS. Interventions can be targeted toward 'at risk' patients.
authors.affiliation: Heart Research Centre, The Royal Melbourne Hospital, Victoria, Australia. barbara.murphy@heartresearchcentre.org
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Murphy
authors.forename: Peter C
authors.initials: PC
authors.lastname: Elliott
authors.forename: Rosemary O
authors.initials: RO
authors.lastname: Higgins
authors.forename: Michael R
authors.initials: MR
authors.lastname: Le Grande
authors.forename: Marian U C
authors.initials: MU
authors.lastname: Worcester
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Goble
authors.forename: James
authors.initials: J
authors.lastname: Tatoulis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000209:etiology*; D001026:Coronary Artery Bypass / Q000523:psychology*; D003863:Depression / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008960:Models, Psychological; D011379:Prognosis; D012959:Socioeconomic Factors