Radioprotective effects of fucoidan in mice treated with total body irradiation.
The effects of fucoidan on the survival rate of mice treated with total body irradiation were examined. BALB/c mice were pretreated with various doses of fucoidan prior to total-body irradiation and were monitored for 30 days. A significant improvement of survival was observed by pretreatment with fucoidan at 100 mg/kg body weight. Using this optimal dosage, survival was examined by radiation dose reduction analysis and a dose reduction factor (DRF) of 1.20 was determined at 30 days post-irradiation. Mice pretreated with fucoidan also exhibited dose-dependent increases in the number of bone marrow cells and endogenous spleen cell colonies at day 9 post-irradiation. It is concluded that the increased survival of whole-body irradiated mice pretreated with fucoidan may be attributable to the radioprotective effects of fucoidan on hematopoietic cell viability, proliferation and/or mobility, possibly through antioxidation or antiinflammatory mechanisms.
Lee
Jeeyoung
J
Department of Veterinary Medicine, College of Veterinary Medicine, Cheju National University, Jeju 690-756, South Korea.
Kim
Jeongtae
J
Moon
Changjong
C
Kim
Sung-Ho
SH
Hyun
Jin Won
JW
Park
Jae Woo
JW
Shin
Taekyun
T
D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005720:Gamma Rays; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D008807:Mice, Inbred BALB C; D000459:Phaeophyceae / Q000737:chemistry; D011134:Polysaccharides / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D015996:Survival Rate; D014916:Whole-Body Irradiation
D011134:Polysaccharides; D011837:Radiation-Protective Agents; C007789:fucoidan