Interferon gamma receptor 1 gene polymorphism in patients with tuberculosis in China.
The aim of the study was to examine the influence of the CA microsatellite polymorphisms of interferon gamma receptor 1 on patients with tuberculosis (TB) in the south-eastern Chinese population. Genomic DNA from patients with TB (n = 155) and ethnically matched controls (n = 89) were genotyped by short tandem repeat-PCR method. The allele frequency of (CA)(25) was 1.70-fold higher among patients than that among controls (95% CI 1.07-2.70) (P = 0.025). Compared with the non-(CA)(25)/non-(CA)(25) reference group, the risk to TB of the carriers of (CA)(25)/(CA)(25) genotypes were 6.46-fold (95% CI 1.40-29.74) (P = 0.0017) higher. On the contrary, the allele frequency of (CA)(26) was 0.29-fold lower in patients than that in controls (95% CI 0.11-0.76) (P = 0.012). Genotypes with (CA)(26) allele were at 0.35-fold (95% CI 0.13-0.98) (P = 0.045) lower to the risk of TB, compared with that of the non-(CA)(26)/non-(CA)(26) in the reference group. The above results indicated that the allele (CA)(25) appeared to be susceptible to TB, while the allele (CA)(26) to be protective towards TB. Our data also suggest that the CA repeat was a highly polymorphic marker and could be used for linkage and association analysis.
Ding
S
S
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang Province, China.
Li
F
F
Wang
J
J
Xu
K
K
Li
L
L
D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017471:Receptors, Interferon / Q000235:genetics*; D014376:Tuberculosis / Q000235:genetics*; D000096743:Interferon gamma Receptor
D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor