title: Validation of radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas: Japanese Orthopaedic Association Committee on Musculoskeletal Tumors Cooperative Study.
abstract: BACKGROUND
  The radiographic evaluation of the response to preoperative chemotherapy for bone and soft tissue sarcomas is based mostly on the change in primary tumor size before and after chemotherapy, as is done for many solid cancers. Its prognostic correlation, however, has hardly been validated.
  
  
  METHODS
  We conducted a retrospective validation study of the Japanese Orthopaedic Association (JOA) radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas as a JOA Committee on Musculoskeletal Tumors cooperative study. A total of 125 consecutive patients with high-grade bone (n = 77) and soft tissue (n = 48) sarcomas treated with neoadjuvant chemotherapy and definitive surgery in 25 tertiary referral hospitals were selected for the study. We investigated the correlation between the tumor size-based radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas provided by the JOA Committee on Musculoskeletal Tumors (hereafter called the JOA criteria) and the patients' overall survival using the Kaplan-Meier method and the log-rank test.
  
  
  RESULTS
  The JOA criteria correlated relatively well with survival for malignant bone tumors (mostly comprising osteosarcoma and Ewing's sarcoma) but not for soft tissue sarcomas, suggesting that the tumor size-based radiographic evaluation criteria for the response to preoperative chemotherapy in patients with soft tissue sarcomas is invalid.
  
  
  CONCLUSIONS
  The JOA criteria, based on the change in primary tumor size, is valid for malignant bone tumors but invalid for soft tissue sarcomas. Other new evaluation modalities of the response to preoperative chemotherapy using innovative functional imaging techniques are needed for soft tissue sarcomas.
authors.affiliation: Department of Orthopaedic Surgery, Osaka National Hospital, Kinki-Block Comprehensive Cancer Center, 2-1-14 Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ueda
authors.forename: Norifumi
authors.initials: N
authors.lastname: Naka
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Araki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishii
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsuchiya
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Mochizuki
authors.forename: Tadao
authors.initials: T
authors.lastname: Tsuboyama
authors.forename: Junya
authors.initials: J
authors.lastname: Toguchida
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Ozaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Murata
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kudawara
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yukihide
authors.initials: Y
authors.lastname: Iwamoto
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yazawa
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kushida
authors.forename: Takanobu
authors.initials: T
authors.lastname: Otsuka
authors.forename: Keiji
authors.initials: K
authors.lastname: Sato
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D011859:Radiography; D012189:Retrospective Studies; D012509:Sarcoma / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D018906:Antineoplastic Agents, Alkylating