title: Scanning 17 candidate genes for association with primary cataracts in the wire-haired Dachshund.
abstract: Primary cataracts are breed-related eye diseases and are common in many dog breeds. In this study, 17 genes (BFSP2, EYA1, FOXE3, FTL, GCNT2, GJA3, GJA8, HSF4, MAF, MIP, PAX6, PITX3, SIX5, SORD, SOX1, SPARC, TRNT1) were evaluated as candidates for primary non-congenital cataracts (CAT) in the Dachshund using microsatellites adjacent to the candidate genes. Linkage and association with CAT was tested in 15 affected and six unaffected wire-haired Dachshunds. Non-parametric linkage analysis and association tests did not reveal significant linkage or association for the candidate gene flanking microsatellites tested. Thus, it is unlikely that the 17 investigated candidate genes harbour a causative mutation for CAT in these Dachshunds.
authors.affiliation: Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p, 30559 Hannover, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Müller
authors.forename: Ottmar
authors.initials: O
authors.lastname: Distl
mesh_terms: D000818:Animals; D002386:Cataract / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D002874:Chromosome Mapping / Q000662:veterinary; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004283:Dog Diseases / Q000235:genetics* / Q000473:pathology*; D004285:Dogs; D020869:Gene Expression Profiling / Q000379:methods / Q000662:veterinary*; D018895:Microsatellite Repeats / Q000235:genetics; D016133:Polymerase Chain Reaction / Q000662:veterinary
chemical_list: D004247:DNA