title: General effect on high-risk persons when general practitioners are trained in intensive treatment of type 2 diabetes.
abstract: OBJECTIVE
  Within the frame of a randomized clinical trial to examine whether training of general practitioners (the intervention group) in intensive lifestyle modification and pharmacological treatment of patients with type 2 diabetes has a spillover effect on individuals with impaired fasting glycaemia (IFG) or impaired glucose tolerance (IGT).
  
  
  METHODS
  A high-risk screening study for type 2 diabetes with an intervention programme, where general practices were randomized to provide standard treatment versus intensive lifestyle modification and pharmacological treatment to newly diagnosed diabetic patients.
  
  
  METHODS
  General practices in Denmark.
  
  
  METHODS
  Of 1821 individuals identified with IFG or IGT, results from oral glucose tolerance tests after one and three years were available in 1510 individuals.
  
  
  METHODS
  Progression rates from IFG and IGT to diabetes and effect of intervention were estimated in a regression model using interval censoring.
  
  
  RESULTS
  A total of 442 persons developed diabetes. There was no significant overall effect of intervention on progression rates. For risk factors, no difference in rate of change was found between randomization groups, but a difference was found between general practices within the same randomization groups.
  
  
  CONCLUSIONS
  General practitioners identify a high number of incident diabetes cases in individuals with IFG or IGT found by high-risk screening. Intervention at the general practitioner's level in intensive treatment type 2 diabetes does not have a significant spillover effect reducing the risk of diabetes from pre-diabetic conditions. This could indicate that intervention strategies should be specifically targeted at individuals with IFG or IGT, either by training general practitioners or directly at the individual level.
authors.affiliation: Steno Diabetes Center, Gentofte, Denmark. SSSR@steno.dk
authors.forename: Signe S
authors.initials: SS
authors.lastname: Rasmussen
authors.forename: Charlotte
authors.initials: C
authors.lastname: Glümer
authors.forename: Annelli
authors.initials: A
authors.lastname: Sandbaek
authors.forename: Torsten
authors.initials: T
authors.lastname: Lauritzen
authors.forename: Knut
authors.initials: K
authors.lastname: Borch-Johnsen
mesh_terms: D000368:Aged; D003718:Denmark; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy; D004502:Education, Medical, Continuing; D005194:Family Practice; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D008019:Life Style; D008403:Mass Screening; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010821:Physicians, Family / Q000193:education; D012307:Risk Factors