title: Bovine dermis: a novel biologic substitute for autologous tissue in sling surgery.
abstract: Women at high risk for sling failure (advanced age, previous surgical failure, and intrinsic sphincter deficiency) underwent either bovine dermis (BOV) or autologous rectus fascia (ARF) pubovaginal sling at two hospitals. "Global cure" encompassed stress, emptying, anatomic, protection, and instability (SEAPI) composite = 0 and subjective satisfaction. Cure of stress urinary incontinence (SUI cure) equaled SEAPI (S) = 0 and negative cough-stress test. Eighty-five women (48 ARF, 37 BOV) completed a 12-month evaluation. Preoperative SEAPI and quality of life indices (QOL) were not statistically different (NS). "Global cure" for ARF and BOV was 60.4% and 54.1%, respectively (NS). "SUI cure" for ARF and BOV was 81.3% and 83.8%, respectively (NS). Postoperative SEAPI and QOL indices were significantly improved for each material; improvement was similar between ARF and BOV groups (NS). BOV is a promising substitute for ARF in women at high risk for surgical failure. Longer follow-up is needed before indications for this material are expanded.
authors.affiliation: Department of Urology, Louisiana State University Health Sciences Center, Shreveport 1501 Kings Highway, Shreveport, LA, 71130, USA.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Wilson
authors.forename: B Jill
authors.initials: BJ
authors.lastname: Williams
authors.forename: Seth
authors.initials: S
authors.lastname: Bilello
authors.forename: Alex
authors.initials: A
authors.lastname: Gomelsky
mesh_terms: D000368:Aged; D000818:Animals; D002417:Cattle; D020405:Dermis / Q000637:transplantation*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011474:Prosthesis Design; D053825:Suburethral Slings; D014183:Transplantation, Heterologous; D014550:Urinary Incontinence, Stress / Q000503:physiopathology / Q000601:surgery*; D014563:Urodynamics