title: [Chronic bacterial infection and echocardiographic parameters indicative of pulmonary hypertension in patients with cystic fibrosis].
abstract: OBJECTIVE
  To examine the relationship between chronic bacterial infection and pulmonary hypertension, using Doppler echocardiography, in patients with cystic fibrosis (CF).
  
  
  METHODS
  A prospective cross-sectional study involving CF patients (>16 years of age) admitted to a program for adults with the disease. The study included 40 patients with a mean age of 23.7 +/- 6.3 years. Patients were submitted to clinical evaluation, Doppler echocardiography, pulmonary function tests, chest X-rays and sputum cultures of Pseudomonas aeruginosa and Burkholderia cepacia.
  
  
  RESULTS
  In terms of the following variables, no significant differences were found between P. aeruginosa-positive patients and P. aeruginosa-negative patients: clinical score (p = 0.472); forced expiratory volume in one second (FEV1; p = 0.693), radiological score (p = 0.760); tricuspid regurgitant jet velocity (TRV, p = 0.330); diameter of the right ventricle (DRV, p = 0.191); and right ventricular/pulmonary artery (RV/PA) systolic acceleration time (SAT, p = 0.330). B. cepacia-positive patients presented significantly lower FEV1 than did B. cepacia-negative patients (p = 0.011). No significant differences were found between B. cepacia-positive patients and B. cepacia-negative patients regarding the following variables: clinical score (p = 0.080); radiological score (p = 0.760); TRV (p = 0.613); DRV (p = 0.429); and RV/PA SAT (p = 0.149).
  
  
  CONCLUSIONS
  Chronic infection with P. aeruginosa or B. cepacia presented no association with pulmonary hypertension in adult CF patients. Pulmonary function was worse in B. cepacia-positive patients than in P. aeruginosa-positive patients.
authors.affiliation: Centro Universitário Metodista, Instituto Porto Alegre, Porto Alegre, RS, Brasil. larove_@hotmail.com
authors.forename: Paula Maria Eidt
authors.initials: PM
authors.lastname: Rovedder
authors.forename: Bruna
authors.initials: B
authors.lastname: Ziegler
authors.forename: Lilian Rech
authors.initials: LR
authors.lastname: Pasin
authors.forename: Antônio Fernando Furlan
authors.initials: AF
authors.lastname: Pinotti
authors.forename: Sérgio Saldanha Menna
authors.initials: SS
authors.lastname: Barreto
authors.forename: Paulo de Tarso Roth
authors.initials: Pde T
authors.lastname: Dalcin
mesh_terms: D000293:Adolescent; D000328:Adult; D019121:Burkholderia Infections / Q000000981:diagnostic imaging*; D016956:Burkholderia cepacia / Q000302:isolation & purification; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging* / Q000382:microbiology; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D018709:Statistics, Nonparametric; D055815:Young Adult