An update on the relationship between the kidney, salt and hypertension.
The relationship between salt intake and blood pressure has been noteworthy for a long time. Nevertheless, the complex hemodynamic alterations associated with the salt-induced blood pressure changes have become clear only quite recently. Despite this knowledge, the concept of Guyton, which postulates that any increase in blood pressure should lead to a pressure natriuresis normalising blood pressure over the long term is still valid. As a conclusion, we have to remember that an elevation of arterial pressure can only be maintained if renal function as indicated by pressure natriuresis is impaired.
Mayer
Gert
G
Division of Nephrology and Hypertensiology, Department of Internal Medicine IV, Innsbruck, Austria. gert.mayer@i-med.ac.at
D000293:Adolescent; D000328:Adult; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002648:Child; D002908:Chronic Disease; D003198:Computer Simulation; D004195:Disease Models, Animal; D005260:Female; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D008297:Male; D008954:Models, Biological; D009154:Mutation; D009318:Natriuresis; D051381:Rats; D012079:Renal Circulation; D017673:Sodium Chloride, Dietary / Q000009:adverse effects*
D017673:Sodium Chloride, Dietary