Variants in the ATM gene associated with a reduced risk of contralateral breast cancer.
Between 5% and 10% of women who survive a first primary breast cancer will subsequently develop a second primary cancer in the contralateral breast. The Women's Environment, Cancer, and Radiation Epidemiology Study was designed to identify genetic and environmental determinants of contralateral breast cancer (CBC). In this study, 708 women with asynchronous CBC served as cases and 1,397 women with unilateral breast cancer served as controls. ATM, a serine-threonine kinase, controls the cellular response to DNA double-strand breaks, and has been implicated in breast cancer risk. Complete mutation screening of the ATM gene in all 2,105 study participants identified 240 distinct sequence variants; only 15 were observed in >1% of subjects. Among the rare variants, deleterious alleles resulting in loss of ATM function were associated with a nonsignificant increase in risk of CBC. In contrast, carriers of common variants had a statistically significant reduction in risk of CBC. Four of these 15 variants were individually associated with a significantly decreased risk of second primary breast cancer [c.1899-55T>G, rate ratio (RR), 0.5; 95% confidence interval (CI), 0.3-0.8; c.3161C>G, RR, 0.5; 95% CI, 0.3-0.9; c.5558A>T, RR, 0.2; 95% CI, 0.1-0.6; c.6348-54T>C RR, 0.2; 95% CI, 0.1-0.8]. These data suggest that some alleles of ATM may exert an antineoplastic effect, perhaps by altering the activity of ATM as an initiator of DNA damage responses or a regulator of p53.
Concannon
Patrick
P
Department of Biochemistry and Molecular Genetics and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908-0733, USA. patcon@virginia.edu
Haile
Robert W
RW
Børresen-Dale
Anne-Lise
AL
Rosenstein
Barry S
BS
Gatti
Richard A
RA
Teraoka
Sharon N
SN
Diep
T Anh
TA
Jansen
Laila
L
Atencio
David P
DP
Langholz
Bryan
B
Capanu
Marinela
M
Liang
Xiaolin
X
Begg
Colin B
CB
Thomas
Duncan C
DC
Bernstein
Leslie
L
Olsen
Jørgen H
JH
Malone
Kathleen E
KE
Lynch
Charles F
CF
Anton-Culver
Hoda
H
Bernstein
Jonine L
JL
D064007:Ataxia Telangiectasia Mutated Proteins; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics*; D004252:DNA Mutational Analysis; D004268:DNA-Binding Proteins / Q000235:genetics*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D016609:Neoplasms, Second Primary / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012307:Risk Factors; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D014481:United States / Q000453:epidemiology
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D025521:Tumor Suppressor Proteins; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D017346:Protein Serine-Threonine Kinases