[The remote effects of neonatal injections of caffeine and piracetam on audiogenic seizure susceptibility in mice of three genotypes].
Neonatal DBA/2J, 101/HY and CBA/Lac/Sto mice (2-7-day-old) were subcutaneously injected with caffeine (200 mg/kg), piracetam (50 mg/kg) or distilled water. At the age of 1 month, they were tested for audiogenic seizure susceptibility (SS). The neonatal injections changed SS in 1-month-old mice in a genotype-dependent manner. Distilled water (control of neonatal pain stimulation) slightly reduced the audiogenic fit severity (arbitrary scores) the effect being most distinct in DBA/2J, less strong in 101/HY strain and absent in CBA. Caffeine neonatal injections induced slight changes in DBA/2J, no changes in CBA and increased SS in 101/HY mice. Piracetam reduced fit intensity in DBA/2J mice but increased it in CBA and, especially, in 101/HY strain. Genotype-dependent differences in physiological mechanisms of audiogenic seizures may be responsible for different remote effects of early treatment.
Markina
N V
NV
Perepelkina
O V
OV
Poletaeva
I I
II
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D004198:Disease Susceptibility; D020195:Epilepsy, Reflex / Q000503:physiopathology*; D005838:Genotype; D051379:Mice; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D010889:Piracetam / Q000008:administration & dosage / Q000494:pharmacology*; D012640:Seizures / Q000503:physiopathology*; D013045:Species Specificity
D002110:Caffeine; D010889:Piracetam