PCR-like cascade reactions in the context of an allosteric enzyme mimic.
A supramolecular allosteric catalyst that exhibits a PCR-like cascade reaction is reported. The complex is triggered by a reaction with an acetate ion, which turns on a catalytic cascade that exponentially increases acetate ion concentration through an acyl transfer reaction.
Yoon
Hyo Jae
HJ
Department of Chemistry and the International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
Mirkin
Chad A
CA
D000085:Acetates / Q000737:chemistry; D040761:Biomimetic Materials / Q000737:chemistry*; D002384:Catalysis; D004247:DNA / Q000032:analysis / Q000737:chemistry; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D017553:Phosphorus Compounds / Q000737:chemistry; D016133:Polymerase Chain Reaction; D012238:Rhodium / Q000737:chemistry; D013457:Sulfur Compounds / Q000737:chemistry
D000085:Acetates; D017553:Phosphorus Compounds; D013457:Sulfur Compounds; D004247:DNA; D012238:Rhodium; D004259:DNA-Directed DNA Polymerase