title: NMO-IgG positive neuromyelitis optica in a patient with myasthenia gravis but no thymectomy.
abstract: Here we report on a 44-year old woman presenting with both myasthenia gravis (MG) and neuromyelitis optica (NMO). MRI showed transverse myelitis extending from C2 to T4, multifocal demyelinating lesions in the supratentorial white matter, and left optic neuritis. Serological analysis demonstrated antibodies to acetylcholine receptors as well as NMO-IgG. To our knowledge, this is the first case of NMO-IgG positive NMO in a patient with MG but no history of thymectomy or immunosuppression.
authors.affiliation: Division of Neurology, Department of Internal Medicine, Universidade Federal do Paraná, Curitiba, Brazil.
authors.forename: Cláudia S K
authors.initials: CS
authors.lastname: Kay
authors.forename: Rosana H
authors.initials: RH
authors.lastname: Scola
authors.forename: Paulo J
authors.initials: PJ
authors.lastname: Lorenzoni
authors.forename: Sven
authors.initials: S
authors.lastname: Jarius
authors.forename: Walter O
authors.initials: WO
authors.lastname: Arruda
authors.forename: Lineu C
authors.initials: LC
authors.lastname: Werneck
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods; D009157:Myasthenia Gravis / Q000150:complications*; D009471:Neuromyelitis Optica / Q000209:etiology* / Q000276:immunology* / Q000473:pathology; D013934:Thymectomy / Q000379:methods
chemical_list: D007074:Immunoglobulin G