Signal transducers and activators of transcription as targets for small organic molecules.
Signal transducers and activators of transcription (STATs) are a family of transcription factors that are of central importance for cellular signaling and have therefore emerged as attractive target proteins for cell-permeable small molecules. This review outlines the basic concept of STAT signaling, the relevance of individual members of the STAT family for cellular signaling and human disease, and generally applicable approaches taken to the identification of small-molecule inhibitors of STATs.
Berg
Thorsten
T
Max Planck Institute of Biochemistry, Department of Molecular Biology, Am Klopferspitz 18, 82152 Martinsried, Germany. berg@biochem.mpg.de
D000595:Amino Acid Sequence; D004247:DNA / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D009930:Organic Chemicals / Q000737:chemistry* / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D017434:Protein Structure, Tertiary; D050791:STAT Transcription Factors / Q000037:antagonists & inhibitors* / Q000737:chemistry; D015398:Signal Transduction / Q000187:drug effects
D009930:Organic Chemicals; D010455:Peptides; D050791:STAT Transcription Factors; D004247:DNA