title: [Primary diffuse large B-cell lymphoma of the uterine cervix--a case report].
abstract: Primary malignant lymphoma of the female genital tract is an extremely rare clinical entity. We report a case of primary non-Hodgkin lymphoma of the uterine cervix. A 68-year-old woman presented with abnormal genital bleeding in May 2002. A coloposcopic examination revealed a mass in the uterine cervix. Magnetic resonance imaging showed a bulky cervical tumor(7.5 x 8 cm)invading the right parametrium and adjacent levator ani muscle. Involvement of pelvic lymph nodes was also observed. The uterine lesion exhibited homogenous hypointensity on T1 weight image and isointense to hyperintense on T2-weight image. No other lesions were detected by the whole-body computed tomography, gallium scintigraphy, and bone marrow examination. Although cytology of the smear from the uterine cervix was nondiagnostic, the histologic examination of the punch biopsy material showed a diffuse proliferation of atypical lymphoid cells. Immunophenotypic studies revealed tumor cells were positive for CD19, CD20, CD30, and k-chain. A diagnosis of diffuse large B-cell lymphoma of the uterine cervix, clinical stage IIE was made. The patient was treated with 6 cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone(CHOP)chemotherapy followed by the involved field irradiation. She remains alive and free of disease more than 5 years after the diagnosis.
authors.affiliation: Dept. of Endocrinology and Metabolism, Internal Medicine, University of The Ryukyus School of Medicine.
authors.forename: Taeko
authors.initials: T
authors.lastname: Okudaira
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Nagasaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyagi
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Nakazato
authors.forename: Naoya
authors.initials: N
authors.lastname: Taira
authors.forename: Wataru
authors.initials: W
authors.lastname: Kudaka
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Maehama
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takasu
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy