Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae).
The methanolic extract of the whole plant of Echium glomeratum Poir. (Boraginaceae) has afforded five pyrrolizidine alkaloids, three that were (7S, 8R)-petranine (1), (7S, 8S)-petranine (2), and (7R, 8R)-petranine (3a) or (7R, 8S)-petranine (3b), comprising a tricyclic pyrrolizidine alkaloids subclass; and two that were known but to the species: 7-angeloylretronecine (4) and 9-angeloylretronecine (5). All compounds were tested against a human tumor panel for cytotoxicity; no activity was observed (EC50 values>20microg/ml).
Alali
Feras Q
FQ
Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan. falali@just.edu.jo
Tahboub
Yahya R
YR
Ibrahim
Eyad S
ES
Qandil
Amjad M
AM
Tawaha
Khaled
K
Burgess
Jason P
JP
Sy
Arlene
A
Nakanishi
Yuka
Y
Kroll
David J
DJ
Oberlies
Nicholas H
NH
D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification; D036661:Echium / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry* / Q000302:isolation & purification*
D001688:Biological Products; D010936:Plant Extracts; D011763:Pyrrolizidine Alkaloids