Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?
The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to increased mean lifespans up to 15%. Furthermore, quercetin-treated daf-16(mgDf50) worms show an enhanced resistance to thermal and oxidative stress. Our data reveal that DAF-16 is not obligatorily required for quercetin-mediated longevity and stress resistance.
Saul
Nadine
N
Humboldt-Universität zu Berlin, Department of Biology, Arboretum, Spaethstr. 80/81, 12437 Berlin, Germany. nadines1976@aol.com
Pietsch
Kerstin
K
Menzel
Ralph
R
Steinberg
Christian E W
CE
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D051858:Forkhead Transcription Factors; D020869:Gene Expression Profiling; D008136:Longevity / Q000187:drug effects / Q000235:genetics*; D009154:Mutation; D018384:Oxidative Stress; D011794:Quercetin / Q000494:pharmacology*; D013696:Temperature; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology*
D000975:Antioxidants; D029742:Caenorhabditis elegans Proteins; D051858:Forkhead Transcription Factors; D014157:Transcription Factors; C108831:daf-16 protein, C elegans; D011794:Quercetin