[Gene expression changes during insulin resistance and "diabesity" in insulin-sensitive tissues and possibilities of their regulation].
Type 2 diabetes mellitus (T2DM) gains considerable and pandemic proportions and becomes noticeable problem in a social and economic sphere. In spite of all effort, exact mechanism of T2DM origin has not been elucidated yet. Studying of transcriptom is one possibility how to explain pathophysiological processes in insulin-sensitive tissues. Obtained data can serve as a base for predicting of new therapeutic targets of this disease. This overall review introduces crucial genes whose level of products changes during T2DM. The article gives notice to a diet composition, which is an important environmental factor, which is able to influence a disease outbreak. Not only the role of fats, but also influence of some plant compounds, which would be able to serve as an alternative to present prophylaxis or treatment of T2DM, have been discussed.
Hosek
J
J
Farmaceutická fakulta, Veterinárni a farmaceutická univerzita, Brno. hhosek@gmail.com
Bartos
M
M
D000273:Adipose Tissue / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D015870:Gene Expression; D007333:Insulin Resistance / Q000235:genetics*; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism