Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor.
The phosphopantetheinyl transferase genes SCO5883 (redU) and SCO6673 were disrupted in Streptomyces coelicolor. The redU mutants did not synthesize undecylprodigiosin, while SCO6673 mutants failed to produce calcium-dependent antibiotic. Neither gene was essential for actinorhodin production or morphological development in S. coelicolor, although their mutation could influence these processes.
Lu
Ya-Wen
YW
Department of Chemistry, Williams College, 47 Lab Campus Dr., Williamstown, MA 01267, USA.
San Roman
Adrianna K
AK
Gehring
Amy M
AM
D000880:Anthraquinones / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D017353:Gene Deletion; D016254:Mutagenesis, Insertional; D010455:Peptides / Q000378:metabolism*; D011353:Prodigiosin / Q000031:analogs & derivatives / Q000096:biosynthesis; D048372:Streptomyces coelicolor / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D017855:Transferases (Other Substituted Phosphate Groups) / Q000235:genetics / Q000378:metabolism*; D000095622:Benzoisochromanequinones
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D010455:Peptides; D011353:Prodigiosin; D017855:Transferases (Other Substituted Phosphate Groups); C040487:CDA antibiotic; C082662:phosphopantetheinyl transferase; C047347:undecylprodigiosin; C013390:actinorhodin; D000095622:Benzoisochromanequinones