Prioritizing Disease Genes by Analysis of Common Elements (PDG-ACE).
Complex diseases are characterized by multiple genetic and environmental influences on disease susceptibility. Since the multiple genetic influences converge on a single phenotype, some commonality may be evident among genes that influence the disease. We exploit this potential commonality among candidate disease genes to prioritize genes for further analysis and to pose novel, statistically significant, biologically plausible hypotheses on disease etiology.
McEachin
Richard C
RC
University of Mich., Ann Arbor, MI, USA.
Keller
Benjamin J
BJ
Zandi
Peter P
PP
Almani
Mohsen
M
McInnis
Melvin G
MG
D000465:Algorithms; D001714:Bipolar Disorder / Q000235:genetics*; D030541:Databases, Genetic; D020022:Genetic Predisposition to Disease; D006801:Humans; D010641:Phenotype; D013358:Subject Headings; D018875:Vocabulary, Controlled