[The influence of postradiation chemical signals of mice on the humoral immune response in recipients in different time relative to antigenic stimulus].
The influence of volatile urine chemosignals of irradiated (4 Gy) mice on the primary humoral immune response to sheep red blood cells in intact recipients was investigated. It was demonstrated that the direction of immunomodulatory effect is dependent upon the time at which the postradiation chemosignals was initially applied. The antibody response to antigen was markedly suppressed in mice that were exposed before antigen injection. When chemosignals applied immediately following inoculation of antigen the antibody response was unaffected. The immune response was increased when chemosignals was loadeded for 1-10 days after immunization. The possible mechanisms of immunomodulation are considered.
Sharetskiĭ
A N
AN
Surinov
B P
BP
Abramova
M R
MR
Karpova
N A
NA
D000818:Animals; D000906:Antibodies / Q000097:blood; D000917:Antibody Formation / Q000528:radiation effects*; D000921:Antibody-Producing Cells / Q000276:immunology / Q000528:radiation effects; D000941:Antigens / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D005720:Gamma Rays; D007108:Immune Tolerance / Q000187:drug effects; D007114:Immunization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000276:immunology* / Q000652:urine*; D012756:Sheep; D012903:Smell / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology*; D013997:Time Factors; D014835:Volatilization
D000906:Antibodies; D000941:Antigens