title: [Expression of TGF-beta receptors in CD8+ T cells of oral lichen planus].
abstract: OBJECTIVE
  To investigate the expression of TGF-beta receptors in CD8+ T cells of oral lichen planus (OLP).
  
  
  METHODS
  Immunohistochemical double labeling technique was used to examine the expression of TGF-betaR I and TGF-betaR II in CD8+ T cells of 28 OLP patients and in 10 controls. The results were compared between the two groups.
  
  
  RESULTS
  The double labeled cells were negative in controls. The positive rates of double labeled cells of CD8+/TGF-betaR I and CD8+/TGF-betaR II in OLP were (8.82 +/- 9.98)% and (1.11 +/- 2.94)% respectively.
  
  
  CONCLUSIONS
  The expression level of TGF-betaR II in CD8+ T cells of OLP did not increase compared with the controls, but the expression of TGF-betaR I increased. The results indicate the abnormal TGF-beta signal transduction in CD8+ T cells of OLP, which may contribute to the persistence of the chronic inflammation in OLP.
authors.affiliation: Department of Stomatology, First Affiliated Hospital, Jinan University, Guangzhou 510630, China. tleil@jnu.edu.cn
authors.forename: Lei
authors.initials: L
authors.lastname: Lei
authors.forename: Miao
authors.initials: M
authors.lastname: Yu
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Gao
authors.forename: Xu-Long
authors.initials: XL
authors.lastname: Zhou
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Zhan
mesh_terms: D000328:Adult; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II