title: A novel method for estimating SBRT delivered dose with beam's-eye-view images.
abstract: Stereotactic body radiation therapy is predicated on a high degree of targeting accuracy. However, inaccurate patient setup as well as intra-fractional motion can hinder the delivery of high doses preferentially to the target. To ensure that the coverage delivered to the patient is as planned, an image-guided verification system has been created to estimate the delivered dose retrospectively. This will not only aid the assessment of treatment techniques, but will also allow for more accurate dose response analysis. Patients with limited hepatic metastases from solid tumors were treated with SBRT. Implanted gold markers were used as target surrogates and a body frame and compression plate provided stereotactic localization and target immobilization, respectively. During treatment, an electronic portal imaging device (EPID), operating in cine mode, collected the exit dose. The sequences of images for each field were processed off-line using in-house software for registration and seed localization. The beam's-eye-view seed positions in the treatment images were compared to those in the DRR's to determine the target shifts in the imaging plane. These target shifts were then imported into the treatment planning software. Each original field was multiplied by the number of images taken during treatment. The calculated shift from each image was then applied to each of the new subfields. Summing all of these subfields together gives the dose distribution that was actually delivered to the patient. The dose-volume histograms for the planned and delivered distributions for four patients' complete treatments are shown. For two of the patients, underdosing due to a setup error or intra-fractional drift was not wholly resolved by subsequent fractions. For one of these patients two alternative corrective strategies have been applied, retrospectively, and the prescribed target coverage recovered for both. The delivered dose can be estimated using the information contained in cine EPID images acquired during irradiation. Calculating the dose actually delivered to the target will allow us to assess treatment procedures as well as more accurately report clinical results.
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA. rberbeco@lroc.harvard.edu
authors.forename: Ross I
authors.initials: RI
authors.lastname: Berbeco
authors.forename: Fred
authors.initials: F
authors.lastname: Hacker
authors.forename: Chris
authors.initials: C
authors.lastname: Zatwarnicki
authors.forename: Sang-June
authors.initials: SJ
authors.lastname: Park
authors.forename: Dan
authors.initials: D
authors.lastname: Ionascu
authors.forename: Desmond
authors.initials: D
authors.lastname: O'Farrell
authors.forename: Harvey J
authors.initials: HJ
authors.lastname: Mamon
mesh_terms: D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D010315:Particle Accelerators; D019047:Phantoms, Imaging; D011874:Radiometry / Q000379:methods*; D011878:Radiotherapy / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D011881:Radiotherapy, Computer-Assisted / Q000379:methods; D015203:Reproducibility of Results; D013238:Stereotaxic Techniques; D016896:Treatment Outcome