A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes.
We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module.
Andreeva
Antonina
A
MRC Centre for Protein Engineering, Cambridge, UK. tony@mrc-lmb.cam.ac.uk
Tidow
Henning
H
D001665:Binding Sites; D017124:Conserved Sequence; D006801:Humans; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D012343:RNA, Transfer / Q000737:chemistry / Q000235:genetics; D017411:Ribonucleoproteins, Small Nuclear / Q000737:chemistry*; D017381:Spliceosomes / Q000378:metabolism*; D016335:Zinc Fingers; D012359:tRNA Methyltransferases / Q000737:chemistry*
D017411:Ribonucleoproteins, Small Nuclear; C552126:U11-U12 small nuclear ribonucleoprotein; D012343:RNA, Transfer; D012359:tRNA Methyltransferases