title: The impact of gene location in the nucleus on transcriptional regulation.
abstract: Localization of genes to different parts of the nucleus has the potential to promote activation or silencing of transcription. Current evidence suggests that these effects are mediated by specific molecular interactions between genes and nuclear structures rather than by partitioning of the nucleus into discrete compartments. A growing body of data identifies the nuclear envelope as a major organizer of location-specific interactions for both silent and active genes.
authors.affiliation: Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12ONN, UK. niall.dillon@csc.mrc.ac.uk <niall.dillon@csc.mrc.ac.uk>
authors.forename: Niall
authors.initials: N
authors.lastname: Dillon
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics*; D002843:Chromatin / Q000378:metabolism; D002875:Chromosomes / Q000235:genetics; D004330:Drosophila; D005786:Gene Expression Regulation; D023061:Gene Order; D006801:Humans; D034881:Nuclear Lamina / Q000378:metabolism; D022022:Nuclear Pore / Q000378:metabolism; D013269:Stochastic Processes; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin