title: Short- and long-term limbic abnormalities after experimental febrile seizures.
abstract: Experimental febrile seizures (FS) are known to promote hyperexcitability of the limbic system and increase the risk for eventual temporal lobe epilepsy (TLE). Early markers of accompanying microstructural and metabolic changes may be provided by in vivo serial MRI. FS were induced in 9-day old rats by hyperthermia. Quantitative multimodal MRI was applied 24 h and 8 weeks later, in rats with FS and age-matched controls, and comprised hippocampal volumetry and proton spectroscopy, and cerebral T2 relaxometry and diffusion tensor imaging (DTI). At 9 weeks histology was performed. Hippocampal T2 relaxation time elevations appeared to be transient. DTI abnormalities detected in the amygdala persisted up to 8 weeks. Hippocampal volumes were not affected. Histology showed increased fiber density and anisotropy in the hippocampus, and reduced neuronal surface area in the amygdala. Quantitative serial MRI is able to detect transient, and most importantly, long-term FS-induced changes that reflect microstructural alterations.
authors.affiliation: Department of Radiology, Maastricht University Hospital, Maastricht, The Netherlands.
authors.forename: Jacobus F A
authors.initials: JF
authors.lastname: Jansen
authors.forename: Evi M P
authors.initials: EM
authors.lastname: Lemmens
authors.forename: Gustav J
authors.initials: GJ
authors.lastname: Strijkers
authors.forename: Jeanine J
authors.initials: JJ
authors.lastname: Prompers
authors.forename: Olaf E M G
authors.initials: OE
authors.lastname: Schijns
authors.forename: M Eline
authors.initials: ME
authors.lastname: Kooi
authors.forename: Emile A M
authors.initials: EA
authors.lastname: Beuls
authors.forename: Klaas
authors.initials: K
authors.lastname: Nicolay
authors.forename: Walter H
authors.initials: WH
authors.lastname: Backes
authors.forename: Govert
authors.initials: G
authors.lastname: Hoogland
mesh_terms: D000818:Animals; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology*; D006979:Hyperthermia, Induced / Q000009:adverse effects; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy; D009434:Neural Pathways / Q000473:pathology; D011522:Protons; D051381:Rats; D017207:Rats, Sprague-Dawley; D003294:Seizures, Febrile / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D013997:Time Factors
chemical_list: D011522:Protons