Pinacol macrocyclization-based route to the polyfused medium-sized CDE ring system of lancifodilactone G.
The polyfused medium-sized CDE ring system of lancifodilactone G is assembled via B-alkyl Suzuki-Miyaura cross-coupling and SmI 2-mediated pinacol macrocyclization as the key strategic steps.
Paquette
Leo A
LA
Evans Chemical Laboratories, The Ohio State University, Columbus, Ohio 43210, USA. paquette@chemistry.ohio-state.edu
Wah Lai
Kwong
K
D034242:Cyclooctanes / Q000138:chemical synthesis; D007454:Iodides / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012493:Samarium / Q000737:chemistry; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry
D034242:Cyclooctanes; D007454:Iodides; D047028:Macrocyclic Compounds; D014315:Triterpenes; C507939:lancifodilactone G; D012493:Samarium; C409809:samarium diiodide