In vivo protein delivery to human liver-derived cells using hepatitis B virus envelope pre-S region.
Human hepatocyte-specific delivery of green fluorescent protein was succeeded in the mouse xenograft model by fusion with hepatitis B virus surface antigen pre-S regions (pre-S(1+2)), not with each pre-S region. The entire pre-S region would be useful for human liver-specific delivery of therapeutic proteins and bio-imaging fluoroproteins in biomedical field.
Kasuya
Takeshi
T
Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.
Yamada
Tadanori
T
Uyeda
Atsuko
A
Matsuzaki
Takashi
T
Okajima
Toshihide
T
Tatematsu
Kenji
K
Tanizawa
Katsuyuki
K
Kuroda
Shun'ichi
S
D002460:Cell Line; D002478:Cells, Cultured; D016503:Drug Delivery Systems / Q000379:methods*; D006515:Hepatitis B virus / Q000378:metabolism*; D022781:Hepatocytes / Q000378:metabolism*; D006801:Humans; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry*; D014759:Viral Envelope Proteins / Q000737:chemistry* / Q000493:pharmacokinetics*
D010455:Peptides; D014759:Viral Envelope Proteins