title: [Levels of amino acids in cerebral spinal fluid in children with cerebral palsy].
abstract: OBJECTIVE
  To study the changes of amino acids in cerebral spinal fluid (CSF) in children with spastic or athetotic cerebral palsy (CP) by examining CSF levels of glutamic acid (Glu), gamma-aminobutyric acid (GABA) and aspartate (ASP).
  
  
  METHODS
  CSF samples were obtained from 13 children with spastic CP, from 14 children with athetotic CP, and from 10 children without central nervous system and infectious diseases (control group). CSF levels of Glu, GABA and ASP were determined by high-performance liquid chromatography.
  
  
  RESULTS
  CSF levels of GABA, ASP and Glu in the control group were 13.04+/-2.19, 10.21+/-0.45 and 8.41+/-2.26 micromol/L, respectively. Compared with the control group, CSF GABA levels in the spastic and the athetotic CP groups (8.02+/-2.03 and 10.01+/-2.68 micromol/L respectively) significantly decreased (P<0.01), whereas CSF levels of Glu (20.99+/-8.15 and 28.77+/-17.62 micromol/L respectively) and Asp (13.53+/-3.93 and 14.02+/-2.88 micromol/L respectively) in the spastic and the athetotic CP groups significantly increased (P<0.01). There were statistical differences in the GABA level between the spastic and the athetotic CP groups (P<0.05). In children with spastic CPCSF Glu level was positively correlated to muscle tension.
  
  
  CONCLUSIONS
  CSF excitatory amino acid levels increased, while CSF inhibitory amino acid levels decreased in children with CP. There were differences for CSF amino acid levels in different types of CP. The changes of amino acid levels may contribute to the pathogenesis of CP.
authors.affiliation: Center of Cerebral Palsy, First Hospital of Xiangtan, Nanhua University, Xiangtan, Hunan 411101, China.
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Yuan
authors.forename: Lian-Ying
authors.initials: LY
authors.lastname: Cheng
authors.forename: Fei
authors.initials: F
authors.lastname: Yin
authors.forename: Guo-Xun
authors.initials: GX
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Peng
authors.forename: Ming-Xiu
authors.initials: MX
authors.lastname: Kang
authors.forename: You-Ming
authors.initials: YM
authors.lastname: Xu
authors.forename: Ruo-Lan
authors.initials: RL
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Wang
mesh_terms: D000596:Amino Acids / Q000134:cerebrospinal fluid*; D002547:Cerebral Palsy / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D009129:Muscle Tonus
chemical_list: D000596:Amino Acids