title: [Sirenomelia as a part of VACTERL association: a study of three cases].
abstract: Sirenomelia, characterized by a fusion of lower limb buds, is rare. Moreover, the coexistence of this malformation with a VACTERL sequence is exceptional. We report, here, three new observations associating these two diseases on fetuses from 14 to 26 weeks gestation. With these three new cases associating sirenomelia and VACTERL, observed in our unit and examined in light of data from the medical literature, we discuss the embryologic origin of such malformations and the nosologic frontiers between these two diseases.
authors.affiliation: Service d'anatomie et de cytologie pathologiques, CHRU de Lille, avenue Oscar-Lambret, Lille cedex, France. ph.charlier@yahoo.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Charlier
authors.forename: Anne-Sylvie
authors.initials: AS
authors.lastname: Valat
authors.forename: Odile
authors.initials: O
authors.lastname: Boute
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Petit
authors.forename: Caroline
authors.initials: C
authors.lastname: Chafiotte
authors.forename: Isabelle
authors.initials: I
authors.lastname: Huynh-Charlier
authors.forename: Bernard
authors.initials: B
authors.lastname: Gosselin
authors.forename: Louise
authors.initials: L
authors.lastname: Devisme
mesh_terms: D000015:Abnormalities, Multiple / Q000196:embryology / Q000473:pathology; D004452:Echocardiography; D004480:Ectromelia / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005333:Fetus / Q000002:abnormalities* / Q000473:pathology*; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D016216:Ultrasonography, Prenatal