Mineral supported facile synthesis of novel 4-hydroxybenzoxazin-2-thione N-nucleosides.
One-pot montmorillonite K-10 clay-supported reactions of substituted/unsubstituted salicylaldehyde and ribosyl/deoxyribosyl thioureas expeditiously yielded novel N-nucleosides, 4-hydroxy-3,4-dihydro-3-(beta-D-ribofuranosyl or beta-D-2'-deoxyribofuranosyl)-2''-benz[e]-1,3-oxazin-2-thione via cycloisomerization of aldehyde intermediate under solvent-free microwave irradiation conditions.
Siddiqui
Ibadur R
IR
Department of Chemistry, Laboratory of Green Technology-Synthesis Division, University of Allahabad, Allahabad, India. irsiddiquiau@rediffmail.com
Srivastava
Vishal
V
Singh
Pravin K
PK
D001546:Bentonite / Q000737:chemistry*; D048588:Benzoxazines / Q000138:chemical synthesis*; D002384:Catalysis; D008872:Microwaves; D009705:Nucleosides / Q000138:chemical synthesis*; D013890:Thiourea / Q000737:chemistry*
D048588:Benzoxazines; D009705:Nucleosides; C503188:montmorillonite K-10; D001546:Bentonite; D013890:Thiourea