title: Not just for Eukarya anymore: protein glycosylation in Bacteria and Archaea.
abstract: Of the many post-translational modifications proteins can undergo, glycosylation is the most prevalent and the most diverse. Today, it is clear that both N-glycosylation and O-glycosylation, once believed to be restricted to eukaryotes, also transpire in Bacteria and Archaea. Indeed, prokaryotic glycoproteins rely on a wider variety of monosaccharide constituents than do those of eukaryotes. In recent years, substantial progress in describing the enzymes involved in bacterial and archaeal glycosylation pathways has been made. It is becoming clear that enhanced knowledge of bacterial glycosylation enzymes may be of therapeutic value, while the demonstrated ability to introduce bacterial glycosylation genes into Escherichia coli represents a major step forward in glyco-engineering. A better understanding of archaeal protein glycosylation provides insight into this post-translational modification across evolution as well as protein processing under extreme conditions. Here, we discuss new structural and biosynthetic findings related to prokaryotic protein glycosylation, until recently a neglected topic.
authors.affiliation: Department of Life Sciences, Ben Gurion University, Beersheva 84105, Israel.
authors.forename: Mehtap
authors.initials: M
authors.lastname: Abu-Qarn
authors.forename: Jerry
authors.initials: J
authors.lastname: Eichler
authors.forename: Nathan
authors.initials: N
authors.lastname: Sharon
mesh_terms: D001105:Archaea / Q000737:chemistry / Q000378:metabolism*; D019843:Archaeal Proteins / Q000378:metabolism*; D001419:Bacteria / Q000737:chemistry / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D016123:Campylobacter jejuni / Q000378:metabolism; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006031:Glycosylation; D019622:Haloferax volcanii / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009344:Neisseria gonorrhoeae / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry* / Q000378:metabolism*; D011487:Protein Conformation
chemical_list: D019843:Archaeal Proteins; D001426:Bacterial Proteins; D011134:Polysaccharides