Visualization of CYP2D6 genotype to phenotype correlation in Korean.
Cytochrome P450 2D6 (CYP2D6) shows high extent of genotypic and phenotypic polymorphism, which causes inter-individual variation in drug disposition of many therapeutic drugs. Genotype and phenotype of CYP2D6 were determined in 130 Koreans. To visualize the genotype-to-phenotype correlation at a glance, a colored map based on CYP2D6 phenotype was created using two cluster algorithms and annotated for CYP2D6 genotypes. The findings with those algorithms were similar to previous study,which suggests the possibility to use this information in individualizing therapy based on the genotype.
Kim
Eun-Young
EY
Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Korea.
Jung
Hyun-Ju
HJ
Lee
Sang-Seop
SS
Shon
Ji-Hong
JH
Shin
Sang-Goo
SG
Shin
Jae-Gook
JG
D000465:Algorithms; D016000:Cluster Analysis; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D003626:Data Display; D005838:Genotype; D006801:Humans; D007723:Korea; D010597:Pharmacogenetics; D010641:Phenotype
D019389:Cytochrome P-450 CYP2D6