[Study on the polymorphism of killer cell immunoglobulin like receptor (KIR) gene with systemic lupus erythematosus of North population in China].
OBJECTIVE
To investigate the polymorphism of KIR genes in systemic lupus erythematosus (SLE) patients, and to study the correlation between KIR genes and susceptibility of SLE.


METHODS
The polymorphism of KIR genes were detected by PCR-SSP technique in 62 patients with SLE and 61 healthy persons as controls from North of China.


RESULTS
The differences of KIR frequency between the SLE group and the control were tested by statistical analysis. The most frequent genotype was KIR 3DP1, 2DL1, 2DP1, 3DL1, 2DL3, 1D, followed by 2DS4, 2DL5, 3DS1, 2DS2, 2DS5 and 2DL2. KIR 2DS1, 2DS3 and 3DP1v were lower in frequency compared with others. The frequency of KIR 3DS1, 2DL2, 2DL5 and 2DL3 were significantly lower in SLE group than that in the control èP<0.01é.


CONCLUSIONS
There may be a association between the polymorphism of KIR genes with SLE in North of China should be investigated further.
Chen
A-Mei
AM
Bioengineering College, Dalian University, Dalian 116622, China. chenam01@163.com
Liu
Qing-Ping
QP
Cui
Xiao-Ying
XY
Cui
Ming-Yu
MY
Yan
Wen-Ying
WY
Xie
Song-Mei
SM
Zhu
Na
N
Wang
Xin-Dang
XD
D000328:Adult; D002681:China; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D054340:Receptors, KIR / Q000235:genetics*
D054340:Receptors, KIR