Medial temporal N-acetyl-aspartate in pediatric major depression.
The medial temporal cortex (MTC) has been implicated in the pathogenesis of pediatric major depressive disorder (MDD). Eleven MDD case-control pairs underwent proton magnetic resonance spectroscopic imaging. N-acetyl-aspartate was lower in the left MTC (27%) in MDD patients versus controls. Lower N-acetyl-aspartate concentrations in MDD patients may reflect reduced neuronal viability.
MacMaster
Frank P
FP
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Moore
Gregory J
GJ
Russell
Aileen
A
Mirza
Yousha
Y
Taormina
S Preeya
SP
Buhagiar
Christian
C
Rosenberg
David R
DR
D000293:Adolescent; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D002648:Child; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D003865:Major Depressive Disorder / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male
D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline