title: Alpha,beta-D-CNA induced rigidity within oligonucleotides.
abstract: Introduction of alpha,beta-D-CNA featuring canonical values of the torsional angles alpha and beta within oligonucleotides leads to an overall stabilization and improved rigidity of the duplex DNA as demonstrated by UV experiments, circular dichroism and corroborated by molecular dynamics simulations.
authors.affiliation: Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique UMR 5068 CNRS, Université Paul Sabatier, 31062, Toulouse Cedex 9, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Dupouy
authors.forename: Nathalie
authors.initials: N
authors.lastname: Iché-Tarrat
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Durrieu
authors.forename: Alain
authors.initials: A
authors.lastname: Vigroux
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Escudier
mesh_terms: D008958:Models, Molecular; D009696:Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D009696:Nucleic Acids; D009841:Oligonucleotides