title: Anti-diarrhoea and analgesic activities of the methanol extract and its fractions of Jasminum amplexicaule Buch.-Ham. (Oleaceae).
abstract: Jasminum amplexicaule Buch.-Ham. (Oleaceae) has been commonly used in the traditional medicine in dysentery, diarrhoea and bellyache in China. In the present work, the methanol extract of Jasminum amplexicaule and different fractions of this extract were studied for anti-diarrhoea and analgesic activities. The anti-diarrhoea activities were investigated using castor oil-induced, magnesium sulphate-induced diarrhoea models, antienteropooling assay and gastrointestinal motility models in mice. The analgesic activities were studied using hot-plate, writhing and formalin models in mice. At the doses of 100, 200 and 400mg/kg, the methanol extract (ME) showed significant and dose-dependent anti-diarrhoea and analgesic activity in these models. The chloroform fraction (CHF), ethyl acetate fraction (EAF) and the residual methanol fraction (RMF) exhibited similar activity using a dose of 200mg/kg in these models. The pharmacological activities of the n-butanol fraction (BUF) were lesser than the ME extract and other fractions. These results may support the fact that this plant is traditionally used to cure diarrhoea and pain.
authors.affiliation: School of Life Science, Sun Yat-Sen University, Guangzhou 510275, PR China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Jia
authors.forename: Weiwei
authors.initials: W
authors.lastname: Su
authors.forename: Wei
authors.initials: W
authors.lastname: Peng
authors.forename: Peibo
authors.initials: P
authors.lastname: Li
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D003967:Diarrhea / Q000188:drug therapy; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D031660:Jasminum / Q000737:chemistry*; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D012997:Solvents / Q000737:chemistry
chemical_list: D000700:Analgesics; D000930:Antidiarrheals; D010936:Plant Extracts; D012997:Solvents