TIM-1 and TIM-3 proteins in immune regulation.
Over the last several years, there has been increasing interest in the role of proteins of the TIM (T cell immunoglobulin and mucin domain) family in regulating immune responses. Despite what the name suggests, proteins of this family function in a much more widespread manner than just on T cells, as we will discuss in this review. We therefore propose that the definition of TIM be adjusted to "transmembrane immunoglobulin and mucin".
Su
Ee Wern
EW
Department of Immunology, University of Pittsburgh, 200 Lothrop street, BST E-1056, Pittsburgh, PA 15261, USA.
Lin
Jean Y
JY
Kane
Lawrence P
LP
D000818:Animals; D006084:Graft Rejection / Q000503:physiopathology / Q000517:prevention & control; D000072596:Hepatitis A Virus Cellular Receptor 1; D000072597:Hepatitis A Virus Cellular Receptor 2; D006801:Humans; D007109:Immunity / Q000502:physiology*; D008213:Lymphocyte Activation / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D008407:Mast Cells / Q000502:physiology; D008562:Membrane Glycoproteins / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D011956:Receptors, Cell Surface / Q000502:physiology; D011991:Receptors, Virus / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology
C491143:HAVCR1 protein, human; C448908:HAVCR2 protein, human; C442240:Havcr1 protein, mouse; D000072596:Hepatitis A Virus Cellular Receptor 1; D000072597:Hepatitis A Virus Cellular Receptor 2; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; C500399:TIM-4 protein, mouse; C408123:phosphatidylserine receptor