title: Extensive transmission of Mycobacterium tuberculosis among children on a school bus.
abstract: We report a tuberculosis outbreak in school children caused by exposure to a sputum-smear positive school bus driver. Exposed children were assessed using 2 versions of interferon-gamma release assays. Fifty-five percent (18/34) had a positive interferon-gamma release assays and 4 children developed tuberculosis. This suggests that transmission may be very efficient in this setting and highlights the need for early diagnosis.
authors.affiliation: Hampshire and Isle of Wight Health Protection Agency, Hampshire, UK. edmundo.neira@ports.nhs.uk
authors.forename: Edmundo
authors.initials: E
authors.lastname: Neira-Munoz
authors.forename: Janette
authors.initials: J
authors.lastname: Smith
authors.forename: Paul
authors.initials: P
authors.lastname: Cockcroft
authors.forename: Damian
authors.initials: D
authors.lastname: Basher
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Abubakar
mesh_terms: D000293:Adolescent; D002648:Child; D004196:Disease Outbreaks; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D013183:Sputum / Q000382:microbiology; D013334:Students; D014195:Travel; D014376:Tuberculosis / Q000453:epidemiology* / Q000635:transmission*
chemical_list: D007371:Interferon-gamma