title: Enantiomeric separation of chiral ruthenium(II) complexes using capillary electrophoresis.
abstract: Capillary zone electrophoresis (CZE) and micellar capillary electrophoresis (MCE) were applied for the enantiomeric separation of nine mononuclear tris(diimine)ruthenium(II) complexes as well as the separation of all stereoisomers of a dinuclear tris(diimine)ruthenium(II) complex. Nine cyclodextrin (CD) based chiral selectors were examined as run buffer additives to evaluate their effectiveness in the enantiomeric separation of tris(diimine)ruthenium(II) complexes. Seven showed enantioselectivity. Sulfated gamma-cyclodextrin (SGC), with four baseline and three partial separations, was found to be the most useful chiral selector. In CZE mode, the derivatized gamma-CDs were more effective than beta-CDs while sulfated CDs work better than carboxymethyl CDs. In MCE mode, hydroxypropyl beta-CD separated the greatest number of tris(diimine) ruthenium(II) complexes. The effects of chiral selector concentration, run buffer pH and concentration, the concentration ratio between chiral selector and other factors were investigated.
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas, USA.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Jiang
authors.forename: Man-Yung
authors.initials: MY
authors.lastname: Tong
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Armstrong
authors.forename: Sirantha
authors.initials: S
authors.lastname: Perera
authors.forename: Ye
authors.initials: Y
authors.lastname: Bao
authors.forename: Frederick M
authors.initials: FM
authors.lastname: Macdonnell
mesh_terms: D002021:Buffers; D003505:Cyclodextrins / Q000737:chemistry; D019075:Electrophoresis, Capillary; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D009942:Organometallic Compounds / Q000737:chemistry* / Q000302:isolation & purification*; D012428:Ruthenium / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002021:Buffers; D003505:Cyclodextrins; D008823:Micelles; D009942:Organometallic Compounds; D012967:Sodium Dodecyl Sulfate; D012428:Ruthenium