Aplastic anaemia in association with coeliac disease: a series of three cases.
We report a series of three patients in whom the diagnoses of aplastic anaemia (AA) and coeliac disease were made concurrently. Haematological manifestations of coeliac disease are well described but this is the first report to suggest an association with aplastic anaemia. 'Silent/atypical coeliac disease', in the absence of gastrointestinal symptoms, is increasingly recognised and patients may present with generalised symptoms, such as malaise and fatigue, which are easily attributable to AA. Immunosuppressive therapy for AA could modulate the course of celiac disease. We recommend clinicians should be vigilant for signs of coeliac disease in patients with AA.
Grey-Davies
E
E
Department of Haematology, St George's Hospital, London, UK. lizgreydavies@doctors.net.uk
Hows
J M
JM
Marsh
J C W
JC
D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood / Q000150:complications* / Q000601:surgery; D016026:Bone Marrow Transplantation; D002446:Celiac Disease / Q000097:blood / Q000150:complications* / Q000601:surgery; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000627:therapeutic use; D005221:Fatigue / Q000209:etiology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D055815:Young Adult
D007166:Immunosuppressive Agents; D016572:Cyclosporine