title: Bipleiophylline, an unprecedented cytotoxic bisindole alkaloid constituted from the bridging of two indole moieties by an aromatic spacer unit.
abstract: A cytotoxic bisindole alkaloid possessing an unprecedented structure in which two indole moieties are bridged by an aromatic spacer unit has been isolated from Alstonia angustifolia. The structure was established by analysis of the spectroscopic data and confirmed by X-ray diffraction analysis. A possible biogenetic pathway from pyrocatechuic acid and pleiocarpamine is presented.
authors.affiliation: Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. tskam@um.edu.my
authors.forename: Toh-Seok
authors.initials: TS
authors.lastname: Kam
authors.forename: Shin-Jowl
authors.initials: SJ
authors.lastname: Tan
authors.forename: Seik-Weng
authors.initials: SW
authors.lastname: Ng
authors.forename: Kanki
authors.initials: K
authors.lastname: Komiyama
mesh_terms: D031051:Alstonia / Q000737:chemistry*; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019169:Jurkat Cells; D007624:KB Cells; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
chemical_list: D026121:Indole Alkaloids