Expression of forkhead transcription factors in human granulosa cells.
Members of the forkhead box O1 (FOXO) family of transcription factors are expressed in granulosa cells during various stages of follicle development, and evidence from rodent and other model systems suggests that they may be involved in regulating follicular activation and oocyte maturation. In this report, we show that FOXO1, FOXO3, and FOXO4 are expressed in human luteinized mural granulosa cells, which may suggest that these transcription factors are also involved in human folliculogenesis and luteinization.
Pisarska
Margareta D
MD
Division of REI, Center for Fertility and Reproductive Medicine, University of California, Los Angeles, California 90048, USA. pisarskam@cshs.org
Kuo
Fang-Ting
FT
Tang
Dahai
D
Zarrini
Parham
P
Khan
Salma
S
Ketefian
Aline
A
D018797:Cell Cycle Proteins; D005260:Female; D005307:Fertilization in Vitro; D000071161:Forkhead Box Protein O1; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006107:Granulosa Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D034461:Luteinization / Q000502:physiology; D010060:Ovulation / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism*
D018797:Cell Cycle Proteins; C085126:FOXO1 protein, human; C499517:FOXO3 protein, human; C108803:FOXO4 protein, human; D000071161:Forkhead Box Protein O1; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors; D014157:Transcription Factors