title: Titanium allergy in dental implant patients: a clinical study on 1500 consecutive patients.
abstract: BACKGROUND
  In dentistry, allergic reactions to Ti implants have not been studied, nor considered by professionals. Placing permanent metal dental implants in allergic patients can provoke type IV or I reactions. Several symptoms have been described, from skin rashes and implant failure, to non-specific immune suppression.
  
  
  OBJECTIVE
  Our objective was to evaluate the presence of titanium allergy by the anamnesis and examination of patients, together with the selective use of cutaneous and epicutaneous testing, in patients treated with or intending to receive dental implants of such material.
  
  
  METHODS
  Thirty-five subjects out of 1500 implant patients treated and/or examined (2002-2004) were selected for Ti allergy analysis. Sixteen presented allergic symptoms after implant placement or unexplained implant failures [allergy compatible response group (ACRG)], while 19 had a history of other allergies, or were heavily Ti exposed during implant surgeries or had explained implant failures [predisposing factors group (PFG)]. Thirty-five controls were randomly selected (CG) in the Allergy Centre. Cutaneous and epicutaneous tests were carried out.
  
  
  RESULTS
  Nine out of the 1500 patients displayed positive (+) reactions to Ti allergy tests (0.6%): eight in the ACRG (50%), one in the PFG (5.3%)(P=0.009) and zero in the control group. Five positives were unexplained implant failures (five out of eight).
  
  
  CONCLUSIONS
  Ti allergy can be detected in dental implant patients, even though its estimated prevalence is low (0.6%). A significantly higher risk of positive allergic reaction was found in patients showing post-op allergy compatible response (ACRG), in which cases allergy tests could be recommended.
authors.affiliation: Clinica Sicilia, Oviedo, Spain. asicilia@clinicasicilia.com
authors.forename: Alberto
authors.initials: A
authors.lastname: Sicilia
authors.forename: Susana
authors.initials: S
authors.lastname: Cuesta
authors.forename: Gerardo
authors.initials: G
authors.lastname: Coma
authors.forename: Ignacio
authors.initials: I
authors.lastname: Arregui
authors.forename: Cristina
authors.initials: C
authors.lastname: Guisasola
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ruiz
authors.forename: Antonio
authors.initials: A
authors.lastname: Maestro
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003722:Dental Alloys / Q000009:adverse effects*; D003758:Dental Implantation, Endosseous / Q000009:adverse effects; D015921:Dental Implants / Q000009:adverse effects*; D019232:Dental Restoration Failure; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014025:Titanium / Q000009:adverse effects / Q000276:immunology*
chemical_list: D003722:Dental Alloys; D015921:Dental Implants; D014025:Titanium