Vanadium-vitamin B12 bioconjugates as potential therapeutics for treating diabetes.
The synthesis and blood glucose lowering properties of the first vanadium-vitamin B(12) bioconjugates are reported.
Mukherjee
Riya
R
Department of Chemistry, Kent State University, Kent, OH 44242, USA.
Donnay
Edward G
EG
Radomski
Michal A
MA
Miller
Catherine
C
Redfern
Duane A
DA
Gericke
Arne
A
Damron
Derek S
DS
Brasch
Nicola E
NE
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D004578:Electron Spin Resonance Spectroscopy; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use*; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D017968:Vanadium Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use*; D014805:Vitamin B 12 / Q000138:chemical synthesis* / Q000627:therapeutic use*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D017968:Vanadium Compounds; D014805:Vitamin B 12