Infectious bursal disease virus type 1-induced suppression of chicken lymphocyte response to mitogen.
Infectious bursal disease type 1 (IBDV-1) caused severe suppression of the proliferative response of normal chicken peripheral blood lymphocytes (PBL) to concanavalin A (Con A). The factors capable of such suppression were not associated with virus particles and were stable at 56 degrees C for 1 h. Their molecular weight ranged from under 100 kDa to over 300 kDa. They were not prostaglandin-like material, and their suppression of PBL was not due to interference with the Con A action.
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Department of Epidemiology and Preventive Medicine, School of Veterinary Medicine, University of California, Davis, California, USA.