[Genetic analysis of premature ovarian failure: role of forkhead and TGF-beta genes].
Premature ovarian failure is a common pathology affecting 1% of women. Although multiple etiologies have been described the majority of cases are idiopathic. Forkhead transcription factors as FOXL2 and FOXO3A are of particular interest in the research of genetic factors related with the pathology as they are present in diverse developmental pathways and ovarian physiology. Similarly, some TGF-beta factors (i.e. BMP 15 and GDF-9) have been demonstrated to play a key role in the regulation, at ovarian level, of female reproduction. In recent years numerous studies have been performed in order to elucidate the implication of these factors in the ovarian physiopathology. The aim of this manuscript is to describe some of these advances in the context of premature ovarian failure.
Lakhal
B
B
Laboratoire de cytogénétique et de biologie de la reproduction, CHU Farhat-Hached, 4000 Sousse, Tunisie.
Laissue
P
P
Elghèzal
H
H
Fellous
M
M
D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics*; D006801:Humans; D009154:Mutation / Q000235:genetics*; D016649:Primary Ovarian Insufficiency / Q000235:genetics* / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000235:genetics*
D051858:Forkhead Transcription Factors; D016212:Transforming Growth Factor beta