Siderophores in fungal physiology and virulence.
Maintaining the appropriate balance of iron between deficiency and toxicity requires fine-tuned control of systems for iron uptake and storage. Both among fungal species and within a single species, different systems for acquisition, storage, and regulation of iron are present. Here we discuss the most recent findings on the mechanisms involved in maintaining iron homeostasis with a focus on siderophores, low-molecular-mass iron chelators, employed for iron uptake and storage. Recently siderophores have been found to be crucial for pathogenicity of animal, as well as plant-pathogenic fungi and for maintenance of plant-fungal symbioses.
Haas
Hubertus
H
Division of Molecular Biology/Biocenter, Innsbruck Medical University, A-6020 Innsbruck, Austria. hubertus.haas@i-med.ac.at
Eisendle
Martin
M
Turgeon
B Gillian
BG
D005656:Fungal Proteins / Q000378:metabolism; D005658:Fungi / Q000472:pathogenicity* / Q000502:physiology*; D007501:Iron / Q000378:metabolism; D010935:Plant Diseases / Q000382:microbiology*; D017262:Siderophores / Q000502:physiology*
D005656:Fungal Proteins; D017262:Siderophores; D007501:Iron