Effect of Shengmai Injection on cardiac function and inflammatory reaction in patients with acute coronary syndrome.
OBJECTIVE
To confirm the effect of Shengmai Injection (, SMI) in improving cardiac function in patients with acute coronary syndrome (ACS) and to explore its influence on inflammatory reaction in patients.


METHODS
Ninety ACS patients were randomized into two groups, the control group treated with conventional therapy and the SMI group treated with SMI. The patients' cardiac function was noted and the content of high sensitive C-reactive protein (hs-CRP) in venous blood was measured before treatment and 1 week and 3 weeks after treatment, so as to observe and compare their changes between the two groups.


RESULTS
The cardiac output, stroke volume and ejection fraction in the SMI group after 3 weeks of treatment were all higher than those in the control group (P<0.05). The serum content of hs-CRP was reduced in both groups (P<0.05), but the reduction in the SMI group was more significant than that in the control group (P<0.05).


CONCLUSIONS
SMI could improve the cardiac function and further inhibit the inflammatory reaction in patients with ACS.
Zhang
Ya-chen
YC
Department of Internal Cardiology, Xinhua Hospital affiliated to Shanghai Jiaotong Medical University School of Medicine, Shanghai, China. zhangyachen65@yahoo.com.cn
Chen
Rui-ming
RM
Lu
Bao-jing
BJ
Rong
Ye-zhi
YZ
D054058:Acute Coronary Syndrome / Q000188:drug therapy* / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000032:analysis; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D006334:Heart Function Tests / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D007267:Injections; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000187:drug effects
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C009252:fructus schizandrae, radix ginseng, radix ophiopogonis drug combination; D002097:C-Reactive Protein