Aminoguanidine ameliorates radiation-induced oxidative lung damage in rats.
OBJECTIVE
To investigate the possible protective effects of aminoguanidine (AG ) on lung damage in whole body irradiated rats.


METHODS
To evaluate the biological damage of radiation on rat lung tissue, lipid peroxidation products were measured using biochemical parameters. Thirty Wistar albino rats were divided into three subgroups: control (C) , irradiation alone (RT), and RT + AG combined. After sacrificing the rats, antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) activities and malondiadehyde (MDA), nitric oxide (NO) levels were evaluated in lung tissue.


RESULTS
Administration of AG resulted in an increase in the activities of CAT, SOD and GSHPx in the lungs. All were reduced after radiation. In addition, AG administration resulted in a decrease in both NO and MDA levels in lung compared with the irradiated group.


CONCLUSIONS
Amnoguanidine increased the endogenous antioxidant defence mechanism in rats and protected the animals from radiation-induced lung toxicity. Moreover, AG may protect against ionizing radiation-induced lung damage because of its antioxidant effect.
Eroglu
Celalettin
C
Department of Radiation Oncology, Erciyes University, Kayseri, Turkey.
Yildiz
Oguz Galip
OG
Saraymen
Recep
R
Soyuer
Serdar
S
Kilic
Eser
E
Ozcan
Servet
S
D000818:Animals; D002374:Catalase / Q000378:metabolism; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects* / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000517:prevention & control*; D011839:Radiation, Ionizing; D051381:Rats; D017208:Rats, Wistar; D012128:Respiratory Distress Syndrome / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism; D014916:Whole-Body Irradiation / Q000009:adverse effects / Q000662:veterinary
D004791:Enzyme Inhibitors; D006146:Guanidines; D009569:Nitric Oxide; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C004479:pimagedine