Morphometric analysis of the inferior olivary complex in infants and adults.
In the literature, few studies detailed morphometric parameters of the inferior olivary complex, and mainly applying biased methods based on counting in a two-dimensional plane. In the present work, the unbiased quantitative method of the optic disector was applied in order to analyse neuronal densities, nuclear volumes and total neuron numbers of the principal (PION), medial (MION) and dorsal (DION) nuclei of the inferior olivary complex in adults (16 male, 6 female; mean age: 37 years) and infants (5 male, 5 female; mean age: 5 months). In both adult and infant series, statistically significant differences were not found in neuronal densities between the various inferior olivary nuclei. All the nuclei showed higher volumes and lower neuronal densities in adults than infants, without statistically significant differences in total neuron numbers, thus suggesting postnatal development of the neuropil.
Porzionato
Andrea
A
Section of Anatomy, Department of Human Anatomy and Physiology, University of Padova, Via A Gabelli 65, 35121 Padova, Italy.
Macchi
Veronica
V
Stecco
Carla
C
Vigato
Enrico
E
Tiengo
Cesare
C
Parenti
Anna
A
De Caro
Raffaele
R
D000328:Adult; D000375:Aging; D002452:Cell Count / Q000379:methods / Q000592:standards; D005260:Female; D006801:Humans; D019044:Image Cytometry / Q000379:methods / Q000592:standards; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008526:Medulla Oblongata / Q000033:anatomy & histology* / Q000166:cytology / Q000254:growth & development; D008875:Middle Aged; D009474:Neurons / Q000166:cytology*; D019581:Neuropil / Q000166:cytology; D009847:Olivary Nucleus / Q000033:anatomy & histology* / Q000166:cytology / Q000254:growth & development