title: Frequency and topographic distribution of brain lesions in pediatric cerebral venous thrombosis.
abstract: OBJECTIVE
  Cerebral sinovenous thrombosis (CSVT) is increasingly encountered in children, including neonates. The purpose of this study was to assess the frequency and topographic distribution of parenchymal brain lesions associated with CSVT in children and to compare these with the known anatomic venous drainage pathways.
  
  
  METHODS
  Brain CT/CT venograms and/or MR imaging/MR venograms of 71 consecutive patients with CSVT were reviewed retrospectively. The patients were grouped into neonates, infants, and older children. The site of CSVT, the location and size of the brain lesions, and the presence of hemorrhage were documented. The frequency of the brain lesions was calculated.
  
  
  RESULTS
  There were 34 neonates, 10 infants, and 27 older children with CSVT who were included. The most common sites of CSVT were the transverse sinuses, the superior sagittal sinus, and the straight sinus. Overall, 37 of 71 children with CSVT had parenchymal brain lesions. There were 21 of 34 neonates, 4 of 10 infants, and 12 of 27 older children who had brain lesions. The most common locations were in the frontal and parietal lobes. The topographic distribution of lesions correlated with the corresponding venous drainage territory in 16 of 21 neonates, all infants, and all older children. The neonates had smaller-sized lesions. Brain lesions were hemorrhagic in 76% of neonates, 75% of infants, and 33% of older children.
  
  
  CONCLUSIONS
  The topographic distribution of brain lesions associated with CSVT correlates with the known drainage territories of the dural venous sinus in children.
authors.affiliation: Department of Radiology, Fatih University Medical School, Ankara, Turkey. mteksam@fatih.edu.tr
authors.forename: M
authors.initials: M
authors.lastname: Teksam
authors.forename: M
authors.initials: M
authors.lastname: Moharir
authors.forename: G
authors.initials: G
authors.lastname: Deveber
authors.forename: M
authors.initials: M
authors.lastname: Shroff
mesh_terms: D000293:Adolescent; D002550:Cerebral Veins / Q000000981:diagnostic imaging* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D009864:Ontario / Q000453:epidemiology; D010690:Phlebography / Q000706:statistics & numerical data; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000453:epidemiology*