title: [Drug-induced liver injury caused by an herbal medicine, bofu-tsu-sho-san].
abstract: A 37-year-old woman was admitted to a hospital with jaundice. Within a couple of weeks, her liver function improved with only symptomatic therapy. About 30 to 60 days before admission, she had taken a herbal medicine, bofu-tsu-sho-san. A diagnosis of drug-induced liver injury was made according to the diagnostic scale proposed at the Digestive Disease Week-Japan 2004. A drug-lymphocyte stimulation test for each ingredient of bofu-tsu-sho-san; the results were positive for Cnidii Rhizoma, Angelicae Radix and Menthae Herba. The liver biopsy specimen revealed features of acute hepatitis. Physicians should be aware that bofu-tsu-sho-san can cause liver injury, as this drug is commonly used as an over-the-counter medicine.
authors.affiliation: Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Motoyama
authors.forename: Masaru
authors.initials: M
authors.lastname: Enomoto
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yasuda
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujii
authors.forename: Sawako
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Shuji
authors.initials: S
authors.lastname: Iwai
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Morikawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Takeda
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tamori
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sakaguchi
authors.forename: Norifumi
authors.initials: N
authors.lastname: Kawada
mesh_terms: D000208:Acute Disease; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D004366:Nonprescription Drugs / Q000009:adverse effects*; D009765:Obesity / Q000188:drug therapy*; D008517:Phytotherapy / Q000009:adverse effects*; D012651:Self Medication / Q000009:adverse effects*
chemical_list: D004365:Drugs, Chinese Herbal; D004366:Nonprescription Drugs; C098310:bofu-tsusho-san