Solvation parameter model of comprehensive two-dimensional gas chromatography separations.
A solvation parameter model was used to generate comprehensive two-dimensional gas chromatography (GC x GC) retention diagrams for 54 solutes on four different stationary phase combinations. Retention diagrams are plots used to predict the relative position of solutes in GC x GC chromatograms. In this study, retention diagrams were based entirely on solute and stationary phase descriptors taken from the literature. The temperature-averaged values of the stationary phase descriptors were used to further simplify the model. The relative positions of the solutes in the retention diagrams were compared with experimentally obtained GC x GC chromatograms. Excellent agreement was observed for each column combination. The model was found to generate primary retention time predictions with standard errors that were approximately 1% of the range of the experimental values and secondary retention time predictions with standard errors that were approximately 5% of the range of the experimental values. It is concluded that the GC x GC solvation parameter model is sufficiently accurate to aid in the identification of optimal column combinations.
Seeley
John V
JV
Oakland University, Department of Chemistry, Rochester, MI 48309, USA. seeley@oakland.edu
Libby
Elise M
EM
Edwards
Kimberly A Hill
KA
Seeley
Stacy K
SK
D002849:Chromatography, Gas / Q000379:methods*; D004867:Equipment Design; D016014:Linear Models; D008956:Models, Chemical; D009930:Organic Chemicals / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D013696:Temperature
D009930:Organic Chemicals; D012997:Solvents