Identification of a new HLA-Cw*07 allele, HLA-Cw*0743, from a Chinese hematopoietic stem cell donor.
A new allele of the human leukocyte antigen C (HLA-C) locus was identified during routine HLA typing of a Chinese hematopoietic stem cell donor in Beijing, China. Sequence analysis of exons 2 and 3 of the HLA-C gene revealed the novel polymorphism. The closest matched allele was HLA-Cw*0710. A comparison of the two alleles showed that HLA-Cw*0743 carried a nucleotide substitution of C to A at codon 99 in exon 3, resulting in an amino acid substitution of serine to tyrosine with no obvious change in protein structure.
Zhu
Haiyan
H
BMT Department, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Zhao
Dandan
D
BMT Department, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Han
Xiaoping
X
BMT Department, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Sun
Jingfen
J
BMT Department, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Da
Wanming
W
BMT Department, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Yu
Li
L
BMT Department, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Gao
Chunji
C
BMT Department, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. gaochunji@hotmail.com.
D000483:Alleles; D019943:Amino Acid Substitution; D044466:Asian People; D002681:China; D015236:HLA-C Antigens / Q000235:genetics*; D006412:Hematopoietic Stem Cells; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D019520:Living Donors; D011110:Polymorphism, Genetic; D017434:Protein Structure, Tertiary / Q000235:genetics; D017422:Sequence Analysis, DNA / Q000379:methods
D015236:HLA-C Antigens