title: Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome following spontaneous rupture of a gouty tophus.
abstract: A 70-year-old man with a 30-year history of gout presented with a ruptured gouty tophus over the right lateral malleolus. After the debridement of the tophus, bilateral arthralgia and pitting edema were observed in his extremities. Treatments with antibiotics and nonsteroidal antiinflammatory drugs were ineffective. However, prednisolone therapy was highly effective, and the patient's symptoms were rapidly ameliorated. Thus, we presume that rupture of a gouty tophus or its surgical treatment might contribute to the occurrence of RS3PE syndrome; however, in our case, the etiology of the syndrome remained unknown.
authors.affiliation: Division of Rheumatology, Jusendo General Hospital, 1-8-16 Ekimae, Koriyama, Fukushima, 963-8585, Japan. kota_sugisaki@mbc.nifty.com
authors.forename: Kota
authors.initials: K
authors.lastname: Sugisaki
authors.forename: Taro
authors.initials: T
authors.lastname: Hirose
mesh_terms: D000368:Aged; D004487:Edema / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D016523:Foot Ulcer / Q000150:complications / Q000473:pathology* / Q000601:surgery; D005938:Glucocorticoids / Q000627:therapeutic use; D006073:Gout / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012422:Rupture, Spontaneous / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D013577:Syndrome; D013585:Synovitis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone