title: Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?
abstract: The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to increased mean lifespans up to 15%. Furthermore, quercetin-treated daf-16(mgDf50) worms show an enhanced resistance to thermal and oxidative stress. Our data reveal that DAF-16 is not obligatorily required for quercetin-mediated longevity and stress resistance.
authors.affiliation: Humboldt-Universität zu Berlin, Department of Biology, Arboretum, Spaethstr. 80/81, 12437 Berlin, Germany. nadines1976@aol.com
authors.forename: Nadine
authors.initials: N
authors.lastname: Saul
authors.forename: Kerstin
authors.initials: K
authors.lastname: Pietsch
authors.forename: Ralph
authors.initials: R
authors.lastname: Menzel
authors.forename: Christian E W
authors.initials: CE
authors.lastname: Steinberg
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D051858:Forkhead Transcription Factors; D020869:Gene Expression Profiling; D008136:Longevity / Q000187:drug effects / Q000235:genetics*; D009154:Mutation; D018384:Oxidative Stress; D011794:Quercetin / Q000494:pharmacology*; D013696:Temperature; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology*
chemical_list: D000975:Antioxidants; D029742:Caenorhabditis elegans Proteins; D051858:Forkhead Transcription Factors; D014157:Transcription Factors; C108831:daf-16 protein, C elegans; D011794:Quercetin