Levels of adhesion molecules bear a relationship to triglyceride levels in type 2 diabetic subjects with proven silent ischemia.
OBJECTIVE
The aim of the study was to examine the levels of adhesion molecules, high-sensitivity C-reactive protein (hs-CRP) and lipid spectrum of type 2 diabetic subjects with proven silent myocardial ischemia.


METHODS
We included in the study 19 patients with ischemia (Group 1) and 16 patients without ischemia (Group 2). We documented silent ischemia by an exercise-myocardial single photon emission computed tomography. We examined the levels of total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, vascular cell adhesion molecule 1, intercellular adhesion molecule 1, E-selectin, HbA1c, microalbuminuria (MAU), hs-CRP and carotid intima-media thickness.


RESULTS
The differences among the values of lipids, adhesion molecules, HbA1c, hs-CRP, MAU between the groups were not statistically significant. E-selectin levels positively correlated with triglyceride levels in the group 1 (Spearman correlation, P<0.05). This correlation was not proven in the Group 2.


CONCLUSIONS
Statistically differences between the study groups were not significant. Levels of E-selectin positively correlated with high triglyceride levels in type 2 diabetic subjects with silent ischemia. This correlation documents a disturbance of the reverse cholesterol transport system.
Adamikova
A
A
Diabetes Center, WHO Collaborating Center, Bata Hospital, Zlin, Czech Republic. adamikova@bnzlin.cz
Kojecky
V
V
Rybka
J
J
Svacina
S
S
D000419:Albuminuria / Q000209:etiology; D002097:C-Reactive Protein / Q000378:metabolism; D002339:Carotid Arteries / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D007511:Ischemia / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D014280:Triglycerides / Q000097:blood*; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D002097:C-Reactive Protein; D019040:E-Selectin; D006442:Glycated Hemoglobin; D018799:Intercellular Adhesion Molecule-1; D014280:Triglycerides; D019010:Vascular Cell Adhesion Molecule-1; C517652:hemoglobin A1c protein, human