[The advances in research on phosphorylation of polyglutamine disease].
Polyglutamine (polyQ) diseases are a group of hereditary neurodegenerative disorders caused by expansion of a glutamine repeat in responsible gene products. To date, the pathogenesis of polyQ diseases is still not very clear, but many researches suggest that phosphorylation of mutant proteins plays a critical role on the process of Huntington's disease, dentatorubral-pallidoluysian atrophy, spinal bulbar muscular atrophy, spinocerebellar ataxia1 and spinocerebellar ataxia 3/Machado-Joseph disease.
Zhou
Ya-fang
YF
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 People's Republic of China.
Jiang
Hong
H
Tang
Jian-guang
JG
Tang
Bei-sha
BS
D020271:Heredodegenerative Disorders, Nervous System / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000378:metabolism; D017827:Machado-Joseph Disease / Q000235:genetics / Q000378:metabolism; D009134:Muscular Atrophy, Spinal; D010455:Peptides / Q000235:genetics* / Q000378:metabolism*; D010766:Phosphorylation / Q000502:physiology*; D013132:Spinocerebellar Degenerations / Q000235:genetics / Q000378:metabolism; D019680:Trinucleotide Repeat Expansion / Q000235:genetics* / Q000502:physiology; D018911:Trinucleotide Repeats / Q000235:genetics
D010455:Peptides; C097188:polyglutamine