title: Medical implications of benzimidazole derivatives as drugs designed for targeting DNA and DNA associated processes.
abstract: Properties of benzimidazole and its derivatives have been studied for over hundred years; special interest of researchers triggered by the fact that 5,6-dimethylbenzimidazole is a component of naturally occurring vitamin B(12). Several antihelminthic, antacid and antibacterial drugs are known which have benzimidazole moiety as their essential constituent. Additionally, several bis- and tris-benzimidazole based systems are well-known for their interaction with DNA and interference with several DNA associated processes. This account gives an overview of the benzimidazole based systems and their relevance in medicinal chemistry.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India. sb@orgchem.iisc.ernet.in
authors.forename: Santanu
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: Padmaparna
authors.initials: P
authors.lastname: Chaudhuri
mesh_terms: D000477:Alkylating Agents / Q000138:chemical synthesis; D000890:Anti-Infective Agents / Q000138:chemical synthesis; D000998:Antiviral Agents / Q000138:chemical synthesis; D001562:Benzimidazoles / Q000737:chemistry*; D002621:Chemistry / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D015195:Drug Design; D006801:Humans; D008956:Models, Chemical; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D000477:Alkylating Agents; D000890:Anti-Infective Agents; D000998:Antiviral Agents; D001562:Benzimidazoles; D004247:DNA