Modes of evolution in a parasite-host interaction: dis-entangling factors determining the evolution of regulated fimbriation in E. coli.
Escherichia coli expresses type-I fimbriae; these are protrusions from the outer cell wall and have been identified as a virulence factor. They are also expressed by commensal strains of E. coli although (at any one time) only by a small proportion of the population. The orthodox interpretation of this is that fimbriation is regulated so as (i) to trigger a host-based release of nutrients in the form of inflammation signals by slightly activating host defenses and (ii) while avoiding a full scale inflammatory response. This article presents a number of computer simulations of the evolution of fimbriae to scrutinize the evolutionary plausibility of this orthodox view. It turns out that these simulations suggest a revised interpretation of the fimbriae mediated parasite-host interaction. Rather than being a passive victim the host is actively providing a niche that evolutionary favors less virulent parasites. The article closes with a number of testable predictions of this model.
Chu
Dominique
D
Computing Laboratory, University of Kent, CT2 7NF Canterbury, UK.
D005075:Biological Evolution; D004926:Escherichia coli / Q000472:pathogenicity / Q000502:physiology*; D010861:Fimbriae, Bacterial; D006790:Host-Parasite Interactions; D008954:Models, Biological; D014774:Virulence