Identification and characterization of Rhox13, a novel X-linked mouse homeobox gene.
Homeobox genes encode transcription factors whose expression organizes programs of development. A number of homeobox genes expressed in reproductive tissues have been identified recently, including a colinear cluster on the X chromosome in mice. This has led to an increased interest in understanding the role(s) of homeobox genes in regulating development of reproductive tissues including the testis, ovary, and placenta. Here we report the identification and characterization of a novel homeobox gene of the paired-like class on the X chromosome distal to the reproductive homeobox (Rhox) cluster in mice. Transcripts are found in the testis and ovary as early as 13.5 days post coitum (dpc). Transcription ceases in the ovary by 3 days post partum (dpp), but continues in the testis through adulthood. The Rhox13 gene encodes a 25.3 kDa protein expressed in the adult testis in germ cells at the basal aspect of the seminiferous epithelium.
Geyer
Christopher B
CB
Gamete Biology Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS Research Triangle Park, NC 27709, USA.
Eddy
Edward M
EM
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018507:Gene Expression Regulation, Developmental; D050172:Genes, X-Linked; D016678:Genome / Q000235:genetics; D018398:Homeodomain Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D015151:Immunoblotting; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D012313:RNA / Q000378:metabolism; D017422:Sequence Analysis, DNA; D013737:Testis / Q000166:cytology
D018398:Homeodomain Proteins; D012313:RNA