title: The effects of body mass index on graft survival in adult recipients transplanted with single pediatric kidneys.
abstract: BACKGROUND
  There is insufficient data on the impact of recipient body mass index (BMI) on the long-term graft survival of adult patients transplanted with single pediatric kidneys.
  
  
  METHODS
  We performed a retrospective analysis of adult patients transplanted with single pediatric kidneys at our center. The recipients were classified into 2 groups: group 1 (BMI > or =30) and group 2 (BMI <30). Donor/recipient demographics, postoperative outcomes and survival rates were compared between the 2 groups.
  
  
  RESULTS
  There was no significant difference in donor/recipient demographics between the 2 groups. In group 1, the death-censored graft survival (DCGS) at 1, 3 and 5 years was 90% at all 3 time points, and in group 2 it was 86, 68 and 60%, respectively (p = 0.05). The mean glomerular filtration rate (with standard deviation in parentheses) at 1, 3 and 5 years was, respectively, 55 (15), 59 (19) and 55 (28) ml/min for group 1, compared to 65 (28), 69 (23) and 67 (20) ml/min in group 2 (p = NS). Multivariate analysis revealed a hazard ratio of 5.12 (95% confidence interval 1.06-24.7; p = 0.04) for graft loss in nonobese patients when compared to obese patients. Obese patients had an increased risk for acute rejections within the first month of transplant (p = 0.02).
  
  
  CONCLUSIONS
  Patients with a BMI > or =30 transplanted with single pediatric kidneys have better DCGS rates when compared to nonobese patients.
authors.affiliation: Tulane Abdominal Transplant Institute, Tulane University Health Sciences Center, 1430 Tulane Avenue SL-45, New Orleans, LA 70112, USA. sbalamut@tulane.edu
authors.forename: Saravanan
authors.initials: S
authors.lastname: Balamuthusamy
authors.forename: Anil
authors.initials: A
authors.lastname: Paramesh
authors.forename: Rubin
authors.initials: R
authors.lastname: Zhang
authors.forename: Sander
authors.initials: S
authors.lastname: Florman
authors.forename: Rajesh
authors.initials: R
authors.lastname: Shenava
authors.forename: Tareq
authors.initials: T
authors.lastname: Islam
authors.forename: Janis
authors.initials: J
authors.lastname: Wagner
authors.forename: Mary
authors.initials: M
authors.lastname: Killackey
authors.forename: Brent
authors.initials: B
authors.lastname: Alper
authors.forename: Eric E
authors.initials: EE
authors.lastname: Simon
authors.forename: Douglas
authors.initials: D
authors.lastname: Slakey
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D051799:Delayed Graft Function / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000188:drug therapy / Q000453:epidemiology*; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D011183:Postoperative Complications / Q000453:epidemiology; D016016:Proportional Hazards Models; D011507:Proteinuria / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D007166:Immunosuppressive Agents