The effect of coenzyme Q10 on the pharmacokinetic parameters of theophylline.
Interaction of a drug with other drugs and dietary supplements is becoming an emerging issue for patients and health insurance authorities due to awareness of adverse drug event. In this study, we examined the effects of coenzyme Q10 (CoQ10), one of the most popular dietary supplements, on the pharmacokinetic parameters of theophylline in rats. The pharmacokinetic parameters of theophylline changed significantly when the drug was administered after five consecutive days of pretreatment with CoQ10. Time to reach maximum plasma concentration of theophylline delayed when the drug was administered after the pretreatment with CoQ10. Maximum plasma concentration and area under the curve of theophylline were about two-fold increased and other pharmacokinetic parameters such as half-life and volume of distribution were also changed significantly. Therefore, although CoQ10 is generally considered a safe dietary supplement, it appears that patients on theophylline therapy should use caution when they take CoQ10.
Baskaran
Rengarajan
R
College of Pharmacy, Yeungnam University, Kyungbuk, Korea.
Shanmugam
Srinivasan
S
Nagayya-Sriraman
Santhoshkumar
S
Kim
Ju Hyun
JH
Jeong
Tae Chun
TC
Yong
Chul Soon
CS
Choi
Han-Gon
HG
Yoo
Bong Kyu
BK
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001993:Bronchodilator Agents / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism; D004347:Drug Interactions; D008297:Male; D011485:Protein Binding; D051381:Rats; D017207:Rats, Sprague-Dawley; D013056:Spectrophotometry, Ultraviolet; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
D000975:Antioxidants; D001993:Bronchodilator Agents; D014451:Ubiquinone; D013806:Theophylline; D019363:Cytochrome P-450 CYP1A1; D019388:Cytochrome P-450 CYP1A2; C024989:coenzyme Q10