title: Assessment of biochemical recurrence rate in patients with pathologically confirmed insignificant prostate cancer.
abstract: OBJECTIVE
  To examine the rate of biochemical recurrence (BCR) in patients with pathologically confirmed insignificant prostate cancer (PIPCa).
  
  
  METHODS
  A total of 1358 patients underwent open retropubic radical prostatectomy at the University Medical Center Eppendorf in Hamburg, Germany, and their specimens were whole-mounted, step-sectioned, and subjected to computer-based three-dimensional reconstruction. We identified patients who fulfilled the Epstein criteria for definition of PIPCa (tumor volume <or=0.5 mL, Gleason score <or=6, organ-confined disease) and we compared the BCR-free rates between the PIPCa and non-PIPCa groups.
  
  
  RESULTS
  Pathologically confirmed insignificant prostate cancer was found in 69 patients (5%). At 1, 2, 5, and 10 years, the BCR-free rate for PIPCa patients was 100% vs, respectively, 97%, 91%, 74%, and 38% for other patients (log-rank P <.0001).
  
  
  CONCLUSIONS
  In patients with PIPCa, radical prostatectomy results in perfect biochemical recurrence rates, which confirms the validity of the PIPCa definition.
authors.affiliation: Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, QC, Canada.
authors.forename: Umberto
authors.initials: U
authors.lastname: Capitanio
authors.forename: Sasha
authors.initials: S
authors.lastname: Ahyai
authors.forename: Markus
authors.initials: M
authors.lastname: Graefen
authors.forename: Claudio
authors.initials: C
authors.lastname: Jeldres
authors.forename: Shahrokh F
authors.initials: SF
authors.lastname: Shariat
authors.forename: Andreas
authors.initials: A
authors.lastname: Erbersdobler
authors.forename: Thorsten
authors.initials: T
authors.lastname: Schlomm
authors.forename: Alexander
authors.initials: A
authors.lastname: Haese
authors.forename: Thomas
authors.initials: T
authors.lastname: Steuber
authors.forename: Hans
authors.initials: H
authors.lastname: Heinzer
authors.forename: Paul
authors.initials: P
authors.lastname: Perrotte
authors.forename: François
authors.initials: F
authors.lastname: Péloquin
authors.forename: Daniel
authors.initials: D
authors.lastname: Pharand
authors.forename: Philippe
authors.initials: P
authors.lastname: Arjane
authors.forename: Hartwig
authors.initials: H
authors.lastname: Huland
authors.forename: Pierre I
authors.initials: PI
authors.lastname: Karakiewicz
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D015331:Cohort Studies; D018572:Disease-Free Survival; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D011467:Prostate / Q000473:pathology / Q000601:surgery; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D012008:Recurrence; D016896:Treatment Outcome