Pseudolymphomatous angiokeratoma: report of three cases and an immunohistological study.
BACKGROUND
Pseudolymphomatous angiokeratoma (PA), originally termed 'acral pseudolymphomatous angiokeratoma of children', is a disorder characterized clinically by development of red nodules on the extremities and histologically by a subepidermal dense lymphocyte infiltrate.


METHODS
We report three cases of PA, with characteristically dense, nodular infiltrate composed predominantly of small lymphocytes, and thick-walled vessels.


RESULTS
Immunohistochemical investigation revealed a dense accumulation of CD20+ cells with CD3+ cells in one case. Infiltrate in the other two cases was mainly composed of CD3+ cells and a mixture of CD4+ and CD8+ cells, with a few cells expressing CD20.


CONCLUSIONS
Our immunohistological results reveal a wide spectrum of cellular infiltrate compositions ranging from T-cell to B-cell predominance.
Okuyama
R
R
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan. rokuyama@mail.tains.tohoku.ac.jp
Masu
T
T
Mizuashi
M
M
Watanabe
M
M
Tagami
H
H
Aiba
S
S
D000328:Adult; D000794:Angiokeratoma / Q000276:immunology / Q000473:pathology*; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007150:Immunohistochemistry; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D055815:Young Adult