title: Effect of admission hypertriglyceridemia on the episodes of severe acute pancreatitis.
abstract: OBJECTIVE
  To investigate the effect of admission hypertriglyceridemia (HTG) on the episodes of severe acute pancreatitis (SAP).
  
  
  METHODS
  One hundred and seventy-six patients with SAP were divided into HTG group (n = 45) and control group (n = 131) according to admission triglyceride (TG) > or = 5.65 mmol/L and < 5.65 mmol/L, respectively. Demographics, etiology, underlying diseases, biochemical parameters, Ranson' s score, acute physiology and chronic heath evaluation II (APACHE II) score, Balthazar's computed tomography (CT) score, complications and mortality were compared. Correlation between admission TG and 24-h APACHE II score was analyzed.
  
  
  RESULTS
  SAP patients with HTG were younger (40.8 +/- 9.3 years vs 52.6 +/- 13.4 years, P < 0.05) with higher etiology rate of overeating, high-fat diet (40.0% vs 14.5%, P < 0.05) and alcohol abuse (46.7% vs 23.7%, P < 0.01), incidence rate of hypocalcemia (86.7% vs 63.4%, P < 0.01) and hypoalbuminemia (84.4% vs 60.3%, P < 0.01), 24-h APACHE II score (13.6 +/- 5.7 vs 10.7 +/- 4.6, P < 0.01) and admission serum glucose (17.7 +/- 7.7 vs 13.4 +/- 6.1, P < 0.01), complication rate of renal failure (51.1% vs 16.8%, P < 0.01), shock (37.9% vs 14.5%, P < 0.01) and infection (37.4% vs 18.3%, P < 0.01) and mortality (13.1% vs 9.1%, P < 0.01). Logistic regression analysis showed a positive correlation between admission TG and 24-h APACHE II score (r = 0 .509, P = 0.004).
  
  
  CONCLUSIONS
  The clinical features of SAP patients with HTG are largely consistent with previous studies. HTG aggravates the episodes of SAP.
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Li-Hui
authors.initials: LH
authors.lastname: Deng
authors.forename: Ping
authors.initials: P
authors.lastname: Xue
authors.forename: Qing
authors.initials: Q
authors.lastname: Xia
authors.forename: Xiao-Nan
authors.initials: XN
authors.lastname: Yang
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Wan
mesh_terms: D018806:APACHE; D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003955:Diagnostic Tests, Routine; D005260:Female; D006505:Hepatitis / Q000150:complications; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications* / Q000000981:diagnostic imaging / Q000401:mortality; D051437:Renal Insufficiency / Q000150:complications; D012769:Shock / Q000150:complications; D014057:Tomography, X-Ray Computed; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides