title: Concurrence of Danish dementia and cataract: insights from the interactions of dementia associated peptides with eye lens alpha-crystallin.
abstract: Familial Danish Dementia (FDD) is an autosomal disease, which is distinguished by gradual loss of vision, deafness, progressive ataxia and dementia. Cataract is the first manifestation of the disease. In this article, we demonstrate a specific correlation between the poisoning of the chaperone activity of the rat eye lens alpha-crystallins, loss of lens transparency in organ culture by the pathogenic form of the Danish dementia peptide, i.e. the reduced Danish dementia peptide (redADan peptide), by a combination of ex vivo, in vitro, biophysical and biochemical techniques. The interaction of redADan peptide and lens crystallins are very specific when compared with another chaperone, HSP-70, underscoring the specificity of the pathogenic form of Danish dementia peptide, redADan, for the early onset of cataract in this disease.
authors.affiliation: Department of Biochemistry, South Campus, Delhi University, New Delhi, India. surolia@nii.res.in
authors.forename: Ira
authors.initials: I
authors.lastname: Surolia
authors.forename: Sharmistha
authors.initials: S
authors.lastname: Sinha
authors.forename: Debi Prasad
authors.initials: DP
authors.lastname: Sarkar
authors.forename: P Yadagiri
authors.initials: PY
authors.lastname: Reddy
authors.forename: G Bhanuprakash
authors.initials: GB
authors.lastname: Reddy
authors.forename: Avadhesha
authors.initials: A
authors.lastname: Surolia
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000375:Aging; D016229:Amyloid beta-Peptides / Q000633:toxicity; D000818:Animals; D001259:Ataxia / Q000150:complications; D002386:Cataract / Q000150:complications*; D003704:Dementia / Q000150:complications*; D004195:Disease Models, Animal; D006801:Humans; D007908:Lens, Crystalline / Q000473:pathology*; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000633:toxicity; D018832:Molecular Chaperones / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000453:epidemiology; D051381:Rats; D014786:Vision Disorders / Q000150:complications; D038201:alpha-Crystallins / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D016229:Amyloid beta-Peptides; C120083:ITM2B protein, human; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D018832:Molecular Chaperones; D038201:alpha-Crystallins