Photoswitched DNA-binding of a photochromic spiropyran.
The dramatically different DNA-binding properties of the two isomeric forms of a photochromic spiropyran have been demonstrated, enabling photoswitched DNA binding. The closed, UV-absorbing form shows no signs of interaction with DNA. Upon UV exposure the spiropyran is isomerized to the open form that binds to DNA by intercalation. The process is fully reversible as the corresponding dissociation process is induced by visible light.
Andersson
Johanna
J
Department of Chemical and Biological Engineering, Physical Chemistry, Chalmers University of Technology, SE-412 96 Göteborg, Sweden.
Li
Shiming
S
Lincoln
Per
P
Andréasson
Joakim
J
D001578:Benzopyrans / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D004247:DNA / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D007211:Indoles / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D009574:Nitro Compounds / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D010777:Photochemistry; D013056:Spectrophotometry, Ultraviolet
D001578:Benzopyrans; D007211:Indoles; D009574:Nitro Compounds; C088184:spiropyran; D004247:DNA; C427203:calf thymus DNA