Medical implications of benzimidazole derivatives as drugs designed for targeting DNA and DNA associated processes.
Properties of benzimidazole and its derivatives have been studied for over hundred years; special interest of researchers triggered by the fact that 5,6-dimethylbenzimidazole is a component of naturally occurring vitamin B(12). Several antihelminthic, antacid and antibacterial drugs are known which have benzimidazole moiety as their essential constituent. Additionally, several bis- and tris-benzimidazole based systems are well-known for their interaction with DNA and interference with several DNA associated processes. This account gives an overview of the benzimidazole based systems and their relevance in medicinal chemistry.
Bhattacharya
Santanu
S
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India. sb@orgchem.iisc.ernet.in
Chaudhuri
Padmaparna
P
D000477:Alkylating Agents / Q000138:chemical synthesis; D000890:Anti-Infective Agents / Q000138:chemical synthesis; D000998:Antiviral Agents / Q000138:chemical synthesis; D001562:Benzimidazoles / Q000737:chemistry*; D002621:Chemistry / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D015195:Drug Design; D006801:Humans; D008956:Models, Chemical; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D013678:Technology, Pharmaceutical / Q000379:methods*
D000477:Alkylating Agents; D000890:Anti-Infective Agents; D000998:Antiviral Agents; D001562:Benzimidazoles; D004247:DNA