Increased prevalence of migraine in Marfan syndrome.
OBJECTIVE
A high prevalence of migraine has been described in various forms of congenital heart disease, with and without shunt. In this study we investigated the prevalence of migraine in patients with Marfan syndrome (MFS).


METHODS
All 457 adult patients with MFS from the participating centres and 194 controls received a validated questionnaire about headache. Migraine was diagnosed according to the International Headache Society criteria, by three independent neurologists, blinded to patient files.


RESULTS
Response rate was 68% and 56% in Marfan patients and controls, respectively. Forty percent of the 309 responding MFS patients (mean age 40+/-14 years; 51% females) and 28% of the 102 controls (mean age 43+/-15 years; 58% females), suffered from migraine (p=0.03). The prevalence of migraine with aura (MA) was 22% in MFS patients and 14% in controls (p=0.06). We found MFS to be an independent risk factor for having overall migraine (OR 1.7; 95%CI 1.1-2.8), also after adjustment for age and gender (OR 1.9; 95%CI 1.1-3.1; p=0.02) and for MA after adjustment for gender (OR 2.0; 95%CI 1.1-3.7; p=0.04). In patient with MFS, previous aortic root surgery appeared to be an independent risk factor for having MA (OR 2.2; 95%CI; 1.2.-4.0, p=0.01) adjusted for gender.


CONCLUSIONS
MFS is an independent risk factor for having overall migraine and MA. Moreover, we found that a history of aortic root surgery seems to be associated with an increased risk of MA.
Vis
Jeroen C
JC
Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands.
Timmermans
Janneke
J
Post
Martijn C
MC
Budts
Werner
W
Schepens
Marc A A M
MA
Thijs
Vincent
V
Schonewille
Wouter J
WJ
de Bie
Rob M A
RM
Plokker
Herbert W M
HW
Tijssen
Jan G P
JG
Mulder
Barbara J M
BJ
D000328:Adult; D001018:Aortic Diseases / Q000453:epidemiology / Q000601:surgery; D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology / Q000601:surgery; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D020325:Migraine with Aura / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires