Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture.
After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell, which was prepared by i.v. of EPS (100 mug/mouse), significantly augmented 2 days after EPS treatment. When NK cells were depleted by rabbit anti-asialo GM1 serum, even the EPS group totally abolished the inhibitory effect on lung metastasis of colon 26-M3.1 cells. EPS can stimulate innate immune system to inhibit tumor metastasis, and its anti-tumor metastasis is associated with macrophage and NK cell activation.
Yoon
Taek Joon
TJ
Department of Food and Nutrition, Yuhan College, Bucheon, South Korea.
Yu
Kwang-Won
KW
Shin
Kwang-Soon
KS
Suh
Hyung Joo
HJ
D000818:Animals; D045744:Cell Line, Tumor; D032661:Cordyceps / Q000276:immunology* / Q000378:metabolism*; D005260:Female; D007113:Immunity, Innate / Q000187:drug effects*; D007155:Immunologic Factors / Q000302:isolation & purification* / Q000378:metabolism* / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000276:immunology; D047589:Leukocyte Reduction Procedures; D051379:Mice; D008807:Mice, Inbred BALB C; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009369:Neoplasms / Q000276:immunology; D011108:Polymers / Q000302:isolation & purification* / Q000378:metabolism* / Q000494:pharmacology
D007155:Immunologic Factors; D011108:Polymers