Monocyte chemoattractant protein-1 in acute coronary syndromes: complex vicious interaction.
Monocyte chemoattractant protein-1 (MCP-1) plays a crucial role both in the initiation and progression of atherosclerosis. MCP-1 is a unique cytokine produced by macrophages, smooth muscle cells and endothelial cells within atherosclerotic plaques and seems to be a reliable indicator of atherosclerotic plaque burden. Higher levels of MCP-1 have been associated with a poor prognosis and increased risk for death independent of other risk factors in patients with acute coronary syndromes. In this paper, we discussed the role of MCP-1 in the pathogenesis of acute coronary syndromes.
Amasyali
Basri
B
Gulhane Military Medical School, Department of Cardiology, Etlik/Ankara, Turkey. dramasyali@yahoo.com
Kose
Sedat
S
Kursaklioglu
Hurkan
H
Barcin
Cem
C
Kilic
Ayhan
A
D054058:Acute Coronary Syndrome / Q000453:epidemiology* / Q000276:immunology*; D050197:Atherosclerosis / Q000453:epidemiology* / Q000276:immunology*; D018932:Chemokine CCL2 / Q000097:blood / Q000276:immunology*; D006801:Humans; D012307:Risk Factors
D018932:Chemokine CCL2