title: Descriptive epidemiology of childhood central nervous system tumours in Tunisia. experience of a single institution over a 15-year period (1990-2004).
abstract: BACKGROUND
  Central nervous system tumours represent 20% of all childhood cancers, and are the second most common group of neoplasms after leukaemias.
  
  
  OBJECTIVE
  To describe epidemiological characteristics of central nervous system tumours in a paediatric Tunisian population.
  
  
  METHODS
  A retrospective study of 492 childhood central nervous system tumours operated between 1990 and 2004 was undertaken. We investigated the age-related location, gender distribution and the histology of all tumours, and adopted the latest WHO classification (2007) in grouping all the tumours.
  
  
  RESULTS
  There were 488 primary and 4 secondary tumours; 426 (86.6%) were intracranial and 66 (13.4%) were intraspinal. Of the 426 intracranial tumours, 214 (50.24%) were supratentorial and 212 (49.76%) were infratentorial. The median age at diagnosis was 8 years, with a male:female ratio of 1.14:1. Low-grade tumours (WHO I/II) constituted 67.3% of all lesions and the rest (32.7%) were high-grade tumours (WHO III/IV). The most common tumour found in our series was astrocytoma (38%), followed by medulloblastoma (16.2%), then ependymoma (6.9%), cystic tumours (6.3%) and craniopharyngioma (5.3%). The overall 5-year survival rate was 45% with a mean follow-up period of 36 months.
  
  
  CONCLUSIONS
  In our patient population, the incidence and distribution of central nervous system tumours were similar to those reported in literature. Overall survival rates varied according to tumour location and histopathology.
authors.affiliation: Department of Pathology, Hospital La Rabta, Tunis, Tunisia.
authors.forename: Salma
authors.initials: S
authors.lastname: Bellil
authors.forename: Faten
authors.initials: F
authors.lastname: Limaiem
authors.forename: Houaïda
authors.initials: H
authors.lastname: Mahfoudhi
authors.forename: Khadija
authors.initials: K
authors.lastname: Bellil
authors.forename: Inès
authors.initials: I
authors.lastname: Chelly
authors.forename: Amina
authors.initials: A
authors.lastname: Mekni
authors.forename: Hafedh
authors.initials: H
authors.lastname: Jemel
authors.forename: Moncef
authors.initials: M
authors.lastname: Khaldi
authors.forename: Slim
authors.initials: S
authors.lastname: Haouet
authors.forename: Moncef
authors.initials: M
authors.lastname: Zitouna
authors.forename: Nidhameddine
authors.initials: N
authors.lastname: Kchir
mesh_terms: D000293:Adolescent; D000367:Age Factors; D016543:Central Nervous System Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D014416:Tunisia / Q000453:epidemiology