The significance of apolipoprotein-B (Apo-B) in the elderly as a predictive factor of cardio-cerebrovascular complications.
In an elderly pool of 3288 subjects (65-84 years of age), taking part in the Italian Longitudinal Studies on Aging (ILSA). We evaluated the prevalence of acute myocardial infarction (AMI), the stroke, the non-fatal AMI+stroke cases in relation to the larger or smaller values of the apolipoprotein-B (Apo-B) level considered as cutoff point of normality (150 mg/100 ml). In addition, during the follow-up of 3 years, we observed the prevalence of all these pathologies (AMI, stroke, non-fatal AMI+stroke) in the subjects who had none of these syndromes at the start of the study period. At last, we studied the percentual occurrence of the parameters indicated by the IDF as signs of the metabolic syndrome (MS), and compared them between the subjects displaying higher or lower values of Apo-B of the normal level. Our results revealed that the Apo-B value may be considered as a predictive factor of lipidemic, atherogenic alterations, and it merits in this sense to be included in the diagnostic criteria of MS. However, it cannot be considered as an independent factor of preventive diagnosis of the non-fatal cardio-cerebrovascular complications.
Motta
Massimo
M
Department of Longevity Sciences, Urology and Neurology, University of Catania, Cannizzaro Hospital, Via Messina 829, I-95124 Catania, Italy. lmotta@unict.it
Bennati
Ettore
E
Cardillo
Elisabeth
E
Ferlito
Laura
L
Passamonte
Michela
M
Malaguarnera
Mariano
M
D000368:Aged; D000369:Aged, 80 and over; D001055:Apolipoproteins B / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000235:genetics*; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics; D050171:Dyslipidemias / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics; D011237:Predictive Value of Tests; D011446:Prospective Studies; D020521:Stroke / Q000453:epidemiology / Q000235:genetics
D001055:Apolipoproteins B