title: Generation of breast cancer stem cells through epithelial-mesenchymal transition.
abstract: Recently, two novel concepts have emerged in cancer biology: the role of so-called "cancer stem cells" in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial cancer cells. Using a mammary tumor progression model, we show that cells possessing both stem and tumorigenic characteristics of "cancer stem cells" can be derived from human mammary epithelial cells following the activation of the Ras-MAPK pathway. The acquisition of these stem and tumorigenic characters is driven by EMT induction.
authors.affiliation: Centre Léon Bérard, Lyon, France.
authors.forename: Anne-Pierre
authors.initials: AP
authors.lastname: Morel
authors.forename: Marjory
authors.initials: M
authors.lastname: Lièvre
authors.forename: Clémence
authors.initials: C
authors.lastname: Thomas
authors.forename: George
authors.initials: G
authors.lastname: Hinkal
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ansieau
authors.forename: Alain
authors.initials: A
authors.lastname: Puisieux
mesh_terms: D001940:Breast / Q000166:cytology; D001943:Breast Neoplasms / Q000473:pathology* / Q000821:virology; D051927:CD24 Antigen / Q000032:analysis / Q000235:genetics; D002455:Cell Division; D003114:Colony-Forming Units Assay; D004847:Epithelial Cells / Q000166:cytology / Q000473:pathology* / Q000821:virology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis; D008648:Mesoderm / Q000473:pathology*; D009362:Neoplasm Metastasis; D012190:Retroviridae; D013234:Stem Cells / Q000166:cytology / Q000473:pathology* / Q000821:virology; D014407:Tumor Cells, Cultured
chemical_list: D051927:CD24 Antigen; D018960:Hyaluronan Receptors