title: Even cancers want commitment: lineage identity and medulloblastoma formation.
abstract: In this issue of Cancer Cell, Yang et al. (2008) and Schüller et al. (2008) show that Hedgehog activation in either multipotent neural stem cells or developmentally restricted progenitors causes only medulloblastomas to form. These data suggest that some stem cell-derived tumors must commit to a specific lineage in order to grow.
authors.affiliation: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ceberha@jhmi.edu
authors.forename: Charles G
authors.initials: CG
authors.lastname: Eberhart
mesh_terms: D000818:Animals; D019070:Cell Lineage; D054022:Cerebrum / Q000473:pathology; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D008527:Medulloblastoma / Q000473:pathology*; D051379:Mice; D009369:Neoplasms / Q000473:pathology*; D009474:Neurons / Q000473:pathology; D000072079:Patched Receptors; D011956:Receptors, Cell Surface / Q000235:genetics; D013234:Stem Cells / Q000473:pathology
chemical_list: D053823:Hedgehog Proteins; D000072079:Patched Receptors; D011956:Receptors, Cell Surface