Magnetic nanoparticles for gene and drug delivery.
Investigations of magnetic micro- and nanoparticles for targeted drug delivery began over 30 years ago. Since that time, major progress has been made in particle design and synthesis techniques, however, very few clinical trials have taken place. Here we review advances in magnetic nanoparticle design, in vitro and animal experiments with magnetic nanoparticle-based drug and gene delivery, and clinical trials of drug targeting.
McBain
Stuart C
SC
Institute for Science & Technology in Medicine, Keele University, Thornburrow Drive, Harsthill, Stoke-on-Trent, UK.
Yiu
Humphrey H P
HH
Dobson
Jon
J
D004247:DNA / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D018390:Gene Targeting / Q000379:methods*; D008280:Magnetics / Q000627:therapeutic use*; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000627:therapeutic use*; D014162:Transfection / Q000379:methods*
D004247:DNA