Cyclopeptides with anti-inflammatory activity from seeds of Annona montana.
Four new cyclopeptides, cyclomontanins A-D (1- 4), annomuricatin C (5), and (+)-corytuberine were isolated from a methanol extract of Annona montana seeds. Their structures were elucidated by 2D NMR analysis, ESIMS/MS fragment evidence, and chemical means. The structure of 1 was confirmed by synthesis. Compounds 1, 3, and 4 exhibited anti-inflammatory activity in vitro using the J774.1 macrophage model.
Chuang
Pei-Hsuan
PH
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
Hsieh
Pei-Wen
PW
Yang
Yu-Liang
YL
Hua
Kuo-Feng
KF
Chang
Fang-Rong
FR
Shiea
Jentaie
J
Wu
Shih-Hsiung
SH
Wu
Yang-Chang
YC
D000818:Animals; D031041:Annona / Q000196:embryology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D010456:Peptides, Cyclic