Identification of loci associated with schizophrenia by genome-wide association and follow-up.
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).
O'Donovan
Michael C
MC
Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK. wpcmod@cf.ac.uk
Craddock
Nicholas
N
Norton
Nadine
N
Williams
Hywel
H
Peirce
Timothy
T
Moskvina
Valentina
V
Nikolov
Ivan
I
Hamshere
Marian
M
Carroll
Liam
L
Georgieva
Lyudmila
L
Dwyer
Sarah
S
Holmans
Peter
P
Marchini
Jonathan L
JL
Spencer
Chris C A
CC
Howie
Bryan
B
Leung
Hin-Tak
HT
Hartmann
Annette M
AM
Möller
Hans-Jürgen
HJ
Morris
Derek W
DW
Shi
Yongyong
Y
Feng
GuoYin
G
Hoffmann
Per
P
Propping
Peter
P
Vasilescu
Catalina
C
Maier
Wolfgang
W
Rietschel
Marcella
M
Zammit
Stanley
S
Schumacher
Johannes
J
Quinn
Emma M
EM
Schulze
Thomas G
TG
Williams
Nigel M
NM
Giegling
Ina
I
Iwata
Nakao
N
Ikeda
Masashi
M
Darvasi
Ariel
A
Shifman
Sagiv
S
He
Lin
L
Duan
Jubao
J
Sanders
Alan R
AR
Levinson
Douglas F
DF
Gejman
Pablo V
PV
Cichon
Sven
S
Nöthen
Markus M
MM
Gill
Michael
M
Corvin
Aiden
A
Rujescu
Dan
D
Kirov
George
G
Owen
Michael J
MJ
Buccola
Nancy G
NG
Mowry
Bryan J
BJ
Freedman
Robert
R
Amin
Farooq
F
Black
Donald W
DW
Silverman
Jeremy M
JM
Byerley
William F
WF
Cloninger
C Robert
CR
D001714:Bipolar Disorder / Q000235:genetics; D016022:Case-Control Studies; D002874:Chromosome Mapping; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
D051741:Kruppel-Like Transcription Factors; C540527:ZNF804A protein, human