[Arterial media calcification in patients with type 2 diabetes mellitus].
Arterial calcification was previously viewed as an inevitable, passive, and degenerative process that occurred at the end stages of atherosclerosis. Recent studies, however, have demonstrated that calcification of arteries is a complex and regulated process. It may occur in conjunction with atherosclerosis or in an isolated form that is commonly associated with diabetes and renal failure. Higher artery calcium scores are associated with increased cardiovascular events, and some aspects of arterial calcification are similar to the biology of forming bone. Arterial calcification can thus be viewed as a distinct inflammatory arteriopathy, much like atherosclerosis and aneurysms, with its own contribution to cardiovascular morbidity and mortality. Current research involves efforts to define the complex interactions between cellular and molecular mediators of arterial calcification and, in particular, the role of endogenous calcification inhibitors. This review discusses the clinical relevance, cellular events, and suspected molecular pathways that control arterial calcification.
Belovici
Maria Isabela
MI
Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Facultatea de Medicină, Clinica a VIa Medicală.
Pandele
G I
GI
D001161:Arteriosclerosis / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D002114:Calcinosis / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism; D006946:Hyperinsulinism / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D043564:Inorganic Pyrophosphatase / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D017540:Tunica Media / Q000378:metabolism* / Q000473:pathology; D014812:Vitamin K / Q000378:metabolism; D000097568:Matrix Gla Protein
D002118:Calcium; D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D018836:Inflammation Mediators; D043564:Inorganic Pyrophosphatase; D020738:Leptin; D010758:Phosphorus; D014812:Vitamin K; D000097568:Matrix Gla Protein