Rapid multistep synthesis of 1,2,4-oxadiazoles in a single continuous microreactor sequence.
A general method for the synthesis of bis-substituted 1,2,4-oxadiazoles from readily available arylnitriles and activated carbonyls in a single continuous microreactor sequence is described. The synthesis incorporates three sequential microreactors to produce 1,2,4-oxadiazoles in approximately 30 min in quantities (40-80 mg) sufficient for full characterization and rapid library supply.
Grant
Daniel
D
The San Diego Center for Chemical Genomics, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, Califoria 92037, USA.
Dahl
Russell
R
Cosford
Nicholas D P
ND
D003500:Cyclization; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods*; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries; D013237:Stereoisomerism
D010069:Oxadiazoles; D054852:Small Molecule Libraries