Occupational exposures and non-Hodgkin's lymphoma: Canadian case-control study.
BACKGROUND
The objective was to study the association between Non-Hodgkin's Lymphoma (NHL) and occupational exposures related to long held occupations among males in six provinces of Canada.


METHODS
A population based case-control study was conducted from 1991 to 1994. Males with newly diagnosed NHL (ICD-10) were stratified by province of residence and age group. A total of 513 incident cases and 1506 population based controls were included in the analysis. Conditional logistic regression was conducted to fit statistical models.


RESULTS
Based on conditional logistic regression modeling, the following factors independently increased the risk of NHL: farmer and machinist as long held occupations; constant exposure to diesel exhaust fumes; constant exposure to ionizing radiation (radium); and personal history of another cancer. Men who had worked for 20 years or more as farmer and machinist were the most likely to develop NHL.


CONCLUSIONS
An increased risk of developing NHL is associated with the following: long held occupations of faer and machinist; exposure to diesel fumes; and exposure to ionizing radiation (radium). The risk of NHL increased with the duration of employment as a farmer or machinist.
Karunanayake
Chandima P
CP
Canadian Centre for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, SK, Canada. cpk646@mail.usask.ca
McDuffie
Helen H
HH
Dosman
James A
JA
Spinelli
John J
JJ
Pahwa
Punam
P
D000328:Adult; D000368:Aged; D000383:Agriculture; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D015386:Hazardous Substances / Q000506:poisoning; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology; D009784:Occupational Diseases / Q000453:epidemiology* / Q000209:etiology; D016273:Occupational Exposure / Q000009:adverse effects*; D011839:Radiation, Ionizing; D011795:Surveys and Questionnaires; D001335:Vehicle Emissions / Q000506:poisoning
D015386:Hazardous Substances; D001335:Vehicle Emissions