title: Alterations of cardiac and lymphocyte beta- adrenoceptors in rat with chronic heart failure.
abstract: The alterations of cardiac and lymphocyte beta-adrenoceptors were observed in the rats with chronic heart failure produced by constriction of both abdominal aorta and renal artery. The results showed that beta(1)-adrenoceptor density and mRNA levels were increased, whereas these levels remained unchanged for beta(2). The concentrationcontractile response curve for isoproterenol was shifted m the right in cardiac atrium, whereas the concentration-CAMP accumulation response curve for isoproterenol in myocardium was not changed. The number of beta-adrenoceptom in blood lymphocyte was markedly reduced. Thus in the heart-failure rats the density of cardiac beta-adrenoceptor was increased accompanying reduced beta-adrenoceptormediated positive inotropic response, suggesting a post adenylate cyclase dysfunction or impaired contractile components. In contrast, the alteration of beta-adrenoceptor in lymphocyte is consistent with the reduced beta-adrenoceptor-mediated inotropic response in heart.
authors: Institute of Vascular Medicine, Third Hospital, Beijing Medical University, 100083, Beijing, China.
authors: P
authors: P
authors: Zhang
authors: Q
authors: Q
authors: Han
authors: Y
authors: Y
authors: Zhang
authors: K
authors: K
authors: Xu
authors: B
authors: B
authors: Tian
authors: Z
authors: Z
authors: Lü
authors: J
authors: J
authors: Guo
authors: M
authors: M
authors: Chen