title: Association of ADIPOR2 with liver function tests in type 2 diabetic subjects.
abstract: OBJECTIVE
  Adiponectin protects against liver dysfunction in insulin-resistant states such as obesity and type 2 diabetes (T2DM), but the role of adiponectin receptors in this disorder is largely unknown. We studied whether common single-nucleotide polymorphisms (SNPs) in ADIPOR1 and ADIPOR2 are associated with liver function tests (LFTs) in human subjects with various degrees of insulin resistance.
  
  
  METHODS
  Serum alanine (ALT) and aspartate (AST) aminotransferases, homeostasis model assessment of insulin resistance (HOMA-IR), -8503 G/A (rs6666089) and +5843 C/T (rs1342387) SNPs in ADIPOR1, -64,241 T/G (rs1029629) and +33447 C/T (rs1044471) SNPs in ADIPOR2 were assessed in 700 white subjects from a population-based study.
  
  
  RESULTS
  In nondiabetic subjects, the at-risk alleles for the common -64,241 T/G and +33447 C/T SNPs in ADIPOR2 were associated with increased circulating adiponectin (P < 0.05 to P < 0.005), but not with LFT. Conversely, in T2DM subjects (who are at risk for liver dysfunction), the same alleles were associated with increased serum ALT and AST (P < 0.05 to P < 0.0001), but not with circulating adiponectin. No significant associations with these parameters were evident for the common -8503 G/A and +5843 C/T SNPs in ADIPOR1. In a replication study, the -64,241 T/G and +33447 C/T SNPs in ADIPOR2 were associated with ALT and AST (P < 0.05 to P < 0.0001) in pooled obese and T2DM subjects.
  
  
  CONCLUSIONS
  Common SNPs in ADIPOR2 are associated with LFT in T2DM subjects, which suggests a possible role of this receptor in liver dysfunction associated with insulin resistance.
authors: Diabetes, Endocrinology and Nutrition Unit, Dr Josep Trueta Hospital, Girona, Spain. uden.alpoez@htrueta.scs.es
authors: Abel
authors: A
authors: López-Bermejo
authors: Patricia
authors: P
authors: Botas-Cervero
authors: Francisco
authors: F
authors: Ortega-Delgado
authors: Elías
authors: E
authors: Delgado
authors: Maria M
authors: MM
authors: García-Gil
authors: Tohru
authors: T
authors: Funahashi
authors: Wifredo
authors: W
authors: Ricart
authors: José M
authors: JM
authors: Fernández-Real
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D008099:Liver / Q000503:physiopathology*; D008107:Liver Diseases / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide; D054419:Receptors, Adiponectin / Q000235:genetics*; D013030:Spain
chemical_list: C499918:ADIPOQ protein, human; C475418:ADIPOR1 protein, human; C475420:ADIPOR2 protein, human; D052242:Adiponectin; D054419:Receptors, Adiponectin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase