Catalytic asymmetric addition of alcohols to imines: enantioselective preparation of chiral N,O-aminals.
The enantioselective addition of alcohols to imine electrophiles has been shown to proceed in the presence of a catalytic amount of a chiral phosphoric acid catalyst. The reaction allows for the formation of the respective chiral N,O-aminals in excellent yield and enantioselectivity. A total of 11 different alcohols and 11 different imines were successfully used as a clear demonstration of the reaction generality.
Li
Guilong
G
Department of Chemistry, University of South Florida, 4202 East Fowler Avenue CHE205A, Tampa, Florida 33620, USA.
Fronczek
Frank R
FR
Antilla
Jon C
JC