title: Progesterone receptor gene polymorphisms are not associated with preterm birth in a Hispanic population.
abstract: OBJECTIVE
  To determine whether increased frequency of mutant alleles of the progesterone receptor gene (PGR) was associated with preterm birth in a population of Hispanic women.
  
  
  METHODS
  Placental DNA from 64 patients who had preterm births and 54 control patients was genotyped for 4 progesterone receptor gene polymorphisms by polymerase chain reaction (PCR) restriction fragment length polymorphism. The chi(2) test and t test were used to calculate statistical significance. Linkage disequilibrium was calculated using the Linkage Disequilibrium Analyzer program.
  
  
  RESULTS
  The genotypic frequencies of the 4 polymorphisms were not significantly different between the study and control groups. In addition, there was complete linkage disequilibrium between V660L, H770H, and PROGINS polymorphisms, but not with +331G/A polymorphism.
  
  
  CONCLUSIONS
  The present study suggests that polymorphisms in the progesterone receptor gene are unlikely to be associated with an increased risk of preterm birth in a Hispanic population.
authors: Research Unit in Reproductive Medicine, UMAE en Ginecologia y Obstetricia, IMSS, Mexico.
authors: Laura
authors: L
authors: Diaz-Cueto
authors: Pablo
authors: P
authors: Dominguez-Lopez
authors: Julio
authors: J
authors: Cantillo-Cabarcas
authors: Gloria
authors: G
authors: Perez-Figueroa
authors: Miguel
authors: M
authors: Arechavaleta-Velasco
authors: Fabian
authors: F
authors: Arechavaleta-Velasco
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008800:Mexico; D010920:Placenta; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics*; D011980:Receptors, Progesterone / Q000235:genetics*
chemical_list: D011980:Receptors, Progesterone