A comparative study of histologic response to different pulp capping materials and a novel endodontic cement.
OBJECTIVE
The aim of this study was to compare dogs' pulp response to capping with calcium hydroxide cement (Dycal), mineral trioxide aggregate (MTA), and a novel endodontic cement (NEC).


METHODS
Twenty-four canine teeth in 6 beagle dogs were buccocervically exposed and capped with MTA, Dycal, or NEC. Eight weeks later, retrieved samples were observed by optical microscope to grade inflammation, formation of dentinal bridge, calcification, necrosis, and presence of odontoblast cells.


RESULTS
No inflammation was observed in MTA and NEC groups, and in 75% of each, dentinal bridge was completely formed. In the Dycal group, inflammation and incomplete dentinal bridge were detected in all cases. Although MTA and NEC groups had no significant difference between them in each measure, the difference between all 3 groups was significant (P < .001).


CONCLUSIONS
MTA and NEC showed similar favorable biologic response in pulp cap treatment, better than Dycal, especially in inducing the formation of dentinal bridge.
Asgary
Saeed
S
Iranian Center for Endodontic Research, Dental Research Center, Shahid Beheshti University M.C., Tehran, Iran.
Eghbal
Mohammad Jafar
MJ
Parirokh
Masoud
M
Ghanavati
Farzin
F
Rahimi
Hessam
H
D017607:Aluminum Compounds / Q000494:pharmacology; D000818:Animals; D017610:Calcium Compounds / Q000494:pharmacology; D002126:Calcium Hydroxide / Q000494:pharmacology; D003738:Dental Cements / Q000494:pharmacology*; D003782:Dental Pulp / Q000187:drug effects*; D003785:Dental Pulp Capping / Q000379:methods*; D003809:Dentin, Secondary / Q000378:metabolism; D004285:Dogs; D004338:Drug Combinations; D008297:Male; D008903:Minerals / Q000494:pharmacology; D010087:Oxides / Q000494:pharmacology; D011446:Prospective Studies; D011897:Random Allocation; D012387:Root Canal Filling Materials / Q000494:pharmacology*; D017640:Silicates / Q000494:pharmacology
D017607:Aluminum Compounds; D017610:Calcium Compounds; D003738:Dental Cements; D004338:Drug Combinations; D008903:Minerals; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; C025702:Dycal; D002126:Calcium Hydroxide