Preparation of biodegradable polycaprolactone/poly (ethylene glycol)/polycaprolactone (PCEC) nanoparticles.
Biodegradable polyetherester copolymer (PCL/PEG/PCL, PCEC) was synthesized by ring-opening polymerization of epsilon-caprolactone initiated by poly(ethylene glycol) (PEG). The PCEC nanoparticles were prepared by solvent diffusion method or w/o/w double emulsion method. The obtained particles' morphology was observed on scanning electron microscopy, and the particle size distribution was determined using Malvern laser particle sizer. Bovine serum albumin was used as the model water-soluble protein drug, which was successfully encapsulated in PCEC nanoparticles, the drug release behavior was studied in detail. The hydrolytic degradation behavior of the PCEC nanoparticles was also studied.
Jia
Wenjuan
W
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.
Gu
YingChun
Y
Gou
MaLing
M
Dai
Mei
M
Li
XingYi
X
Kan
Bing
B
Yang
JinLiang
J
Song
QiFang
Q
Wei
YuQuan
Y
Qian
ZhiYong
Z
D000818:Animals; D002417:Cattle; D016503:Drug Delivery Systems; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D011091:Polyesters / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry
D011091:Polyesters; C016240:polycaprolactone; D011092:Polyethylene Glycols