title: Evaluation of porcine dermal collagen (Permacol) used in abdominal wall reconstruction.
abstract: Various methods have been employed to reconstruct complex abdominal wall defects. Structural prosthetic materials such as polypropylene mesh and ePTFE (expanded polytetrafluoroethylene) have been widely used to close these large fascial defects, however, complications with infection and adhesions have led to the recent use of more biocompatible implants. Permacol (acellular porcine dermis) is used as a dermal scaffold, which eventually becomes vascularised and remodelled to reconstruct the abdominal wall in these complex patients. A retrospective review was performed of all patients who underwent consecutive abdominal wall reconstruction with Permacol at our institution in the year 2006. Twenty-eight patients were identified and included in our study. Factors evaluated were: body mass index, relevant co-morbidities, aetiology of hernia, hernia defect size based on CT scan and intraoperative measurement, size of Permacol implant, length of hospital stay, and postoperative complications. Surgical technique was standardised among six surgeons and involved a single layer of acellular porcine dermis as a subfascial 'underlay' graft under moderate tension upon maximal hernia reduction. Tissue expanders were not required for skin closure. Out of 28 patients, 12 were male and 16 were female. Mean intraoperative hernia size was 150 cm(2) (range of 10 cm(2) to 600 cm(2)). Mean age was 55 years with an average body mass index (BMI) of 34 (largest BMI of 61.4). Defects were attributed to either a previous laparotomy incision or open abdomen. Mean hospital stay was 9.67 days. At a mean follow-up of sixteen months, there were three recurrent hernias (10.7%) based on physical examination and postoperative CT scan evaluation. One patient developed a superficial wound dehiscence which was successfully treated with local wound care and one patient developed a cellulitis which was successfully treated with antibiotic therapy. Four patients (14.3%) developed a chronic, non-infected fluid collection lasting >one month all of which resolved. No patient required removal of the implant due to infection. Permacol can be successfully used in the reconstruction of both small and large ventral hernias. This biodegradable matrix serves as a safe and useful alternative to both synthetic mesh and AlloDerm.
authors: Cooper University Hospital, University of Medicine and Dentistry New Jersey, Division of Plastic Surgery, Surgery Department, Three Cooper Plaza, Suite 411, Camden, NJ 08103, USA.
authors: Patrick W
authors: PW
authors: Hsu
authors: Christopher J
authors: CJ
authors: Salgado
authors: Kathryn
authors: K
authors: Kent
authors: Matthew
authors: M
authors: Finnegan
authors: Mark
authors: M
authors: Pello
authors: Robert
authors: R
authors: Simons
authors: Umur
authors: U
authors: Atabek
authors: Brian
authors: B
authors: Kann
mesh_terms: D034861:Abdominal Wall / Q000503:physiopathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D015992:Body Mass Index; D015331:Cohort Studies; D003094:Collagen / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006555:Hernia, Ventral / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000503:physiopathology; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies; D018570:Risk Assessment; D013529:Surgical Wound Dehiscence / Q000503:physiopathology; D013552:Swine; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology
chemical_list: C440568:Alloderm; D003094:Collagen