Cardiac findings in fetal and pediatric autopsies: a five-year retrospective review.
This review aims to determine the spectrum of cardiac findings in our fetal and pediatric postmortem population and provide an analysis of associated extracardiac malformations and genetic abnormalities. Pediatric autopsy reports from 2003 to 2007 inclusive were reviewed and cases with cardiac pathology selected for analysis. Over the 5-year period, 119 cases (10.8%) with abnormal cardiac findings were identified from a total of 1102 postmortem examinations. Of these cardiac cases, 42% were after termination of pregnancy for fetal anomaly, 29% after fetal demise, 14% after neonatal unit death, 3% after hospital inpatient death, and 11% after sudden unexpected death. Structural abnormality cases numbered 107 (90%), with ventricular septal defect as the most common individual defect. Nonstructural abnormality cases, such as myocarditis, numbered 12 (10%). Extracardiac malformations were identified in 78%. Chromosome or gene aberrations were detected in 37%. This review highlights the potential benefit of introducing routine fetal anomaly scanning, the need for cardiac pathology training for pediatric pathologists, and the importance of examination of the heart and associated vessels in all cases to provide parents with as much information as possible and aid identification of the etiology and associations of cardiac pathology.
Grant
Elena K
EK
Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, UK.
Evans
Margaret J
MJ
D000025:Abortion, Eugenic; D000328:Adult; D001344:Autopsy; D009202:Cardiomyopathies / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology / Q000473:pathology*; D006345:Heart Septal Defects, Ventricular / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult