title: Task complexity enhances response inhibition deficits in childhood and adolescent attention-deficit/hyperactivity disorder: a meta-regression analysis.
abstract: BACKGROUND
  The ability to inhibit motor responses, as assessed by the stop-signal reaction time (SSRT), is impaired in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). However, the between-study variation in effect sizes is large. The aim of this study was to investigate whether this variability can be explained by between-study variation in Go task complexity.
  
  
  METHODS
  Forty-one studies comparing children or adolescents diagnosed with ADHD to normal control subjects were incorporated in a random-effects meta-regression analysis. The independent variables were a global index of Go task complexity (i.e., mean reaction time in control subjects [RTc]) and a more specific index (i.e., spatial compatibility of the stimulus-response mapping). The dependent variable was the SSRT difference between ADHD and control subjects.
  
  
  RESULTS
  The SSRT difference increased significantly with increasing RTc. Moreover, the SSRT difference was significantly increased in studies that employed a noncompatible, that is, arbitrary, mapping compared with studies that incorporated a spatially compatible stimulus-response mapping.
  
  
  CONCLUSIONS
  These results indicate that inhibitory dysfunction in children and adolescents with ADHD varies with task complexity: inhibitory dysfunction in ADHD is most pronounced for spatially noncompatible responses. Explanations in terms of inhibition and working memory deficits and a tentative neurobiological explanation are briefly discussed.
authors: Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands. h.m.huizenga@uva.nl
authors: Hilde M
authors: HM
authors: Huizenga
authors: Bianca M C W
authors: BM
authors: van Bers
authors: Jacqueline
authors: J
authors: Plat
authors: Wery P M
authors: WP
authors: van den Wildenberg
authors: Maurits W
authors: MW
authors: van der Molen
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D002648:Child; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008569:Memory Disorders; D009048:Motor Skills; D011930:Reaction Time / Q000502:physiology*; D012044:Regression Analysis; D013647:Task Performance and Analysis