title: Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631.
abstract: Five chicken lines were experimentally infected with a HPAI H7N1 virus, to examine the variation in susceptibility to infection. Three lines showed high susceptibility to the virus, while two showed some resistance, with 7 out of 20, and 11 out of 15 birds, respectively, remaining healthy and surviving the experimental infection. Genotyping for the G/A polymorphism at position 2032 of Mx cDNA showed that one line was fixed for the G allele, and two were segregating for A and G alleles. Birds in the other two lines were selected to be fixed for the A allele. Statistical analyses indicated that the Mx genotype did not affect the clinical status or the time course of infection after viral inoculation.
authors: Parco Tecnologico Padano, CERSA, Polo Universitario, Lodi, Italy.
authors: Laura
authors: L
authors: Sironi
authors: John L
authors: JL
authors: Williams
authors: Ana M
authors: AM
authors: Moreno-Martin
authors: Paola
authors: P
authors: Ramelli
authors: Alessandra
authors: A
authors: Stella
authors: Han
authors: H
authors: Jianlin
authors: Steffen
authors: S
authors: Weigend
authors: Guerino
authors: G
authors: Lombardi
authors: Paolo
authors: P
authors: Cordioli
authors: Paola
authors: P
authors: Mariani
mesh_terms: D000596:Amino Acids / Q000235:genetics; D000818:Animals; D002645:Chickens / Q000276:immunology* / Q000821:virology; D004198:Disease Susceptibility; D019204:GTP-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D053126:Influenza A Virus, H7N7 Subtype / Q000235:genetics*; D005585:Influenza in Birds / Q000235:genetics / Q000821:virology; D009976:Orthomyxoviridae Infections / Q000235:genetics; D011110:Polymorphism, Genetic; D011201:Poultry Diseases / Q000235:genetics
chemical_list: D000596:Amino Acids; D019204:GTP-Binding Proteins