[Expression and its significance of eosinophil major basic protein in chronic rhinosinusitis].
OBJECTIVE
To evaluate the expression of eosinophil major basic protein (MBP) in chronic rhinosinusitis (CRS) and discuss the role of MBP in the pathogenesis in CRS.


METHODS
Thirty-eight nasal mucus obtained from CRS patients were used to detect the expression of MBP by Elisa assay. Thirty nasal mucus samples from health people were used as control.


RESULTS
The expression of MBP of nasal mucus obtained from CRS patients was obviously higher than that of nasal mucus obtained from control. There was significant statistical difference (P < 0.01).


CONCLUSIONS
MBP was involved in the formation of CRS.
Hou
Jing
J
Department of Otorhinolaryngology Head and Neck Surgery, Tongren Hospital, Capital University of Medical Science, Beijing 100073, China.
Zhou
Bing
B
Zhang
Luo
L
Li
Yunchuan
Y
Liu
Ming
M
Wei
Yongxiang
Y
Huang
Qian
Q
Wang
Yang
Y
D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000378:metabolism*; D016022:Case-Control Studies; D002908:Chronic Disease; D047093:Eosinophil Major Basic Protein; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism; D011509:Proteoglycans / Q000378:metabolism*; D012852:Sinusitis / Q000378:metabolism* / Q000473:pathology
D001798:Blood Proteins; D011509:Proteoglycans; C074129:PRG2 protein, human; D047093:Eosinophil Major Basic Protein