Does gestrinone antagonize the effects of estrogen on endometrial implants upon the peritoneum of rats?
OBJECTIVE
To evaluate the effects of estrogen treatment in combination with gestrinone on an experimental rat model of endometriosis.


METHODS
Uterine transplants were attached to the peritoneum of female Wistar rats via a surgical autotransplantation technique. The implanted area was measured during the proestrus phase and after hormonal treatment. We performed morphometric analysis and examined the macroscopic and morphometric alterations of endometrial implants after hormonal treatment in ovariectomized rats.


RESULTS
The high dose of estrogen caused macroscopic increases in the endometrial implant group compared with other groups, which were similar to increases in the proestrus phase. The low dose showed morphometric development of implants, such as an increase in number of endometrial glands, leukocyte infiltration and mitosis. Gestrinone antagonized both doses of estrogen.


CONCLUSIONS
Our findings suggest that gestrinone antagonizes estrogen's effects on rat peritoneal endometrial implants.
Lobo
Vera Lúcia Rodrigues
VL
Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Soares
José Maria
JM
de Jesus Simões
Manuel
M
Simões
Ricardo dos Santos
Rdos S
de Lima
Geraldo Rodrigues
GR
Baracat
Edmund C
EC
D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004715:Endometriosis / Q000188:drug therapy* / Q000473:pathology; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D004967:Estrogens / Q000627:therapeutic use*; D005260:Female; D005867:Gestrinone / Q000627:therapeutic use*; D010052:Ovariectomy; D011372:Progestins / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D004965:Estrogen Antagonists; D004967:Estrogens; D011372:Progestins; D005867:Gestrinone