title: Collagen type 3 alpha 1 polymorphism and risk of pelvic organ prolapse.
abstract: OBJECTIVE
  To investigate whether pelvic organ prolapse (POP) is associated with collagen 3 alpha 1 (COL3A1) polymorphisms and other factors.
  
  
  METHODS
  A case-control association study was conducted with 84 women affected with POP and 147 controls. The genotypes of nucleotides COL3A1 rs1800255 and COL3A1 rs1801184 polymorphisms were ascertained by polymerase chain reaction and restriction fragment length polymorphism analysis.
  
  
  RESULTS
  The distribution of the COL3A1 rs1800255 genotypes was significantly different among affected women and controls. Older age and incidence of COL3A1 rs1800255 genotype AA were significantly associated with risk of POP.
  
  
  CONCLUSIONS
  There may be an association between COL3A1 genotype and risk of POP.
authors: Graduate Institute of Integrated Medicine, China Medical University Hospital, Taichung, Taiwan.
authors: Huey-Yi
authors: HY
authors: Chen
authors: Ya-Wen
authors: YW
authors: Chung
authors: Wei-Yong
authors: WY
authors: Lin
authors: Jiunn-Chin
authors: JC
authors: Wang
authors: Fuu-Jen
authors: FJ
authors: Tsai
authors: Chang-Hai
authors: CH
authors: Tsai
mesh_terms: D000328:Adult; D000367:Age Factors; D001483:Base Sequence; D016022:Case-Control Studies; D024061:Collagen Type III / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014596:Uterine Prolapse / Q000235:genetics* / Q000503:physiopathology
chemical_list: C439971:COL3A1 protein, human; D024061:Collagen Type III