Bilateral infiltrative disease of the extraocular muscles: a rare clinical presentation of early stage chronic lymphocytic leukemia.
Orbital involvement in chronic lymphocytic leukemia (CLL) is highly unusual and most commonly involves hemorrhage or soft tissue infiltration in advanced disease. We report a case of rapid onset bilateral orbital muscle infiltration as the presenting feature of early stage CLL. In addition, we demonstrate clinico-pathological correlation with an identical chronic B-cell lymphocytic infiltrate in both orbit and bone marrow, with good response of the orbital disease to local radiotherapy.
Ramkissoon
Yashin D
YD
Moorfields Eye Hospital, London, United Kingdom.
Lee
Richard W J
RW
Malik
Rizwan
R
Hsuan
James D
JD
Potts
Mike J
MJ
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D003131:Combined Modality Therapy; D007839:Functional Laterality; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D017254:Leukemic Infiltration / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009801:Oculomotor Muscles / Q000187:drug effects / Q000473:pathology*; D009918:Orbital Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D011878:Radiotherapy
D015703:Antigens, CD; D005938:Glucocorticoids; D008775:Methylprednisolone