Cytomegalovirus infection with lissencephaly.
Lissencephaly is a malformation of the brain in which the brain surface is smooth, rather than convoluted. Among the various causes of lissencephaly, infection by a virus during pregnancy plays an important role. Cytomegalovirus (CMV) is an important pathogen causing this anomaly. We present this case of a young female with 24-week-gestation diagnosed on ultrasound as carrying an anomalous fetus with lissencephalic features. At autopsy, there were multiple intra-nuclear CMV inclusions in the brain and the kidneys. This case is presented for its rarity and for the documentation of the tissue localization of CMV inclusions at autopsy.
Joseph
Leena Dennis
LD
Department of Pathology, Sri Ramachandra University, Chennai, Tamil Nadu, India.
Pushpalatha
Kuruvilla
Sarah
S
D037881:Aborted Fetus / Q000473:pathology* / Q000821:virology*; D001921:Brain / Q000473:pathology / Q000821:virology; D002467:Cell Nucleus / Q000821:virology; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D045586:Intranuclear Inclusion Bodies; D007668:Kidney / Q000473:pathology / Q000821:virology; D054082:Lissencephaly / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology* / Q000821:virology; D011247:Pregnancy; D014463:Ultrasonography; D055815:Young Adult