Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity.
Hydroxycitric acid (HCA), the main compound of Garcinia cambogia extract, is a competitive blocker of ATP-citrate-lyase, presenting a potential inhibition of fatty acid biosynthesis. Glucomannan fibers, abundant in Amorphophallus konjac, seem to reduce the absorption kinetics of dietary fat. Therefore, the aim of this double-blind randomized study was to evaluate the pharmacotherapeutic efficacy of standardized extracts of G. cambogia (52.4% HCA) plus A. konjac (94.9% glucomannan) in the treatment of obesity. Fifty-eight obese subjects (BMI 30.0-39.9 kg/m(2)) were assigned to the placebo group (n = 26) or the treatment group (n = 32); no dietary restrictions were applied. Over a 12-week period, subjects were given daily doses of either Garcinia (2.4 g) plus Konjac (1.5 g) or placebo prior to their main meals (3 times/day). Before the start of treatment, and every 4 weeks thereafter, the following were recorded: height, weight, circumferences and body composition, resting energy expenditure (REE), lipid profile and glucose levels. The treatment had no significant effect on anthropometric parameters, REE, triglycerides or glucose levels. However, a significant reduction was observed in total cholesterol (-32.0 +/- 35.1 mg/dL) and LDL-c levels (-28.7 +/- 32.7 mg/dL) in the treated group, the final levels being significantly lower than those of the placebo group (p = 0.008 and p = 0.020, respectively). The results obtained suggest that the treatment had a significant hypocholesterolemic effect, without influencing the anthropometric or calorimetric parameters tested.
Vasques
Carlos A R
CA
Instituto de Ciências da Saúde, Ciências Farmacêuticas, Centro Universitário Feevale, RS-239, 2755, 93352-000 Novo Hamburgo-RS, Brazil. carlosrv@feevale.br
Rossetto
Simone
S
Halmenschlager
Graziele
G
Linden
Rafael
R
Heckler
Eliane
E
Fernandez
Maria S Poblador
MS
Alonso
José L Lancho
JL
D000328:Adult; D031056:Amorphophallus / Q000737:chemistry*; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D004311:Double-Blind Method; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism; D029761:Garcinia cambogia / Q000737:chemistry*; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D010919:Placebos; D010936:Plant Extracts / Q000627:therapeutic use*; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D010919:Placebos; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol