title: Catalytic enantioselective Reformatsky reaction with ortho-substituted diarylketones.
abstract: The catalytic enantioselective Reformatsky reaction with ortho-substituted diarylketones with good enantioselectivities and moderate to good yields is reported. A readily available BINOL derivative is used as a chiral catalyst, and the reactions are performed with ethyl iodoacetate as a nucleophile and Me2Zn as the zinc source. The presence of air was found to be crucial to achieve an effective C-C bond formation pointing to a radical mechanism.
authors: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
authors: M Angeles
authors: MA
authors: Fernández-Ibáñez
authors: Beatriz
authors: B
authors: Maciá
authors: Adriaan J
authors: AJ
authors: Minnaard
authors: Ben L
authors: BL
authors: Feringa
mesh_terms: D000438:Alcohols / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000438:Alcohols; D007659:Ketones