Carcinoma-associated retinopathy-an electrophysiological and immunohistochemical correlation.
OBJECTIVE
To correlate the clinical, electrophysiological, and immunohistochemical findings in patients suffering from carcinoma-associated retinopathy.


METHODS
Four patients with visual loss were included in this retrospective, observational consecutive case series. Electrophysiology and immunohistochemical analysis were performed to confirm the diagnosis of carcinoma-associated retinopathy.


RESULTS
Immunohistochemistry revealed a marked interindividual variability of antibody reactions against different retinal cell layers of individual patients. The electrophysiological changes corresponded to the respective immunohistochemical findings.


CONCLUSIONS
Carcinoma-associated retinopathy is a heterogeneous disease, caused by different antiretinal antibodies and leading to different electrophysiological abnormalities. Diagnosis should not be delayed as undetected and thus untreated malignancy can be the cause.
Link
Barbara
B
Department of Ophthalmology, University of Erlangen-Nuernberg, Erlangen, Germany. barbara.link@uk-erlangen.de
Schlötzer-Schrehardt
Ursula
U
Jünemann
Anselm
A
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D004585:Electrooculography; D004594:Electrophysiology; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000276:immunology; D012160:Retina / Q000276:immunology; D012164:Retinal Diseases / Q000175:diagnosis* / Q000276:immunology; D012189:Retrospective Studies
D001323:Autoantibodies