Formulations for intermittent release of parathyroid hormone (1-34) and local enhancement of osteoblast activities.
The objective of these studies was to develop simple, implantable devices that intermittently release PTH(1-34) and thus could be used for locally stimulating bone formation. The formulations were based on the association polymer system of cellulose acetate phthalate and Pluronic F-127. Release profiles for intermittent devices showed five discrete peaks, whereas sustained devices exhibited zero-order kinetics. Osteoblastic activity was greater for cells intermittently treated with PTH(1-34) compared to sustained exposure. These controlled release devices delivering PTH(1-34) in an intermittent manner may be useful for affecting osteoblast activities in a localized area.
Jeon
J H
JH
Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506-0070, USA.
Puleo
D A
DA
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001682:Biological Availability; D002460:Cell Line; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D000242:Cyclic AMP / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000737:chemistry; D005079:Excipients / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D051379:Mice; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015675:Osteocalcin / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects*; D010281:Parathyroid Hormone / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D020442:Poloxamer / Q000737:chemistry
D003692:Delayed-Action Preparations; D005079:Excipients; D010281:Parathyroid Hormone; D015675:Osteocalcin; D020442:Poloxamer; D002482:Cellulose; C011708:cellulose acetate phthalate; D000242:Cyclic AMP; D000469:Alkaline Phosphatase