title: cneViewer: a database of conserved non-coding elements for studies of tissue-specific gene regulation.
abstract: There are thousands of strongly conserved non-coding elements (CNEs) in vertebrate genomes, and their functions remain largely unknown. However, without biologically relevant criteria for prioritizing them, selecting a particular CNE sequences to study can be haphazard. To address this problem, we present cneViewer-a database and webtool that systematizes information on conserved non-coding DNA elements in zebrafish. A key feature here is the ability to search for CNEs that may be relevant to tissue-specific gene regulation, based on known developmental expression patterns of nearby genes. cneViewer provides this and other organizing features that significantly facilitate experimental design and CNE analysis.
authors: Department of Biology, Boston College, Chestnut Hill, MA 02467, USA.
authors: Jason
authors: J
authors: Persampieri
authors: Deborah I
authors: DI
authors: Ritter
authors: Daniel
authors: D
authors: Lees
authors: Jessica
authors: J
authors: Lehoczky
authors: Qiang
authors: Q
authors: Li
authors: Su
authors: S
authors: Guo
authors: Jeffrey H
authors: JH
authors: Chuang
mesh_terms: D000818:Animals; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D017124:Conserved Sequence; D004247:DNA / Q000737:chemistry; D030541:Databases, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D020407:Internet; D008969:Molecular Sequence Data; D012045:Regulatory Sequences, Nucleic Acid; D012984:Software; D015027:Zebrafish / Q000235:genetics*
chemical_list: D004247:DNA