title: IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver.
abstract: IL-17A is originally identified as a proinflammatory cytokine that induces neutrophils. Although IL-17A production by CD4(+) Th17 T cells is well documented, it is not clear whether IL-17A is produced and participates in the innate immune response against infections. In the present report, we demonstrate that IL-17A is expressed in the liver of mice infected with Listeria monocytogenes from an early stage of infection. IL-17A is important in protective immunity at an early stage of listerial infection in the liver because IL-17A-deficient mice showed aggravation of the protective response. The major IL-17A-producing cells at the early stage were TCR gammadelta T cells expressing TCR Vgamma4 or Vgamma6. Interestingly, TCR gammadelta T cells expressing both IFN-gamma and IL-17A were hardly detected, indicating that the IL-17A-producing TCR gammadelta T cells are distinct from IFN-gamma-producing gammadelta T cells, similar to the distinction between Th17 and Th1 in CD4(+) T cells. All the results suggest that IL-17A is a newly discovered effector molecule produced by TCR gammadelta T cells, which is important in innate immunity in the liver.
authors: Molecular Microbiology Group, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
authors: Satoru
authors: S
authors: Hamada
authors: Masayuki
authors: M
authors: Umemura
authors: Takeru
authors: T
authors: Shiono
authors: Kensho
authors: K
authors: Tanaka
authors: Ayano
authors: A
authors: Yahagi
authors: M Dilara
authors: MD
authors: Begum
authors: Kiyotetsu
authors: K
authors: Oshiro
authors: Yuko
authors: Y
authors: Okamoto
authors: Hisami
authors: H
authors: Watanabe
authors: Kazuyoshi
authors: K
authors: Kawakami
authors: Christina
authors: C
authors: Roark
authors: Willi K
authors: WK
authors: Born
authors: Rebecca
authors: R
authors: O'Brien
authors: Koichi
authors: K
authors: Ikuta
authors: Hiromichi
authors: H
authors: Ishikawa
authors: Susumu
authors: S
authors: Nakae
authors: Yoichiro
authors: Y
authors: Iwakura
authors: Takao
authors: T
authors: Ohta
authors: Goro
authors: G
authors: Matsuzaki
mesh_terms: D000818:Animals; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000096:biosynthesis; D020381:Interleukin-17 / Q000096:biosynthesis / Q000276:immunology*; D008089:Listeria monocytogenes; D008088:Listeriosis / Q000276:immunology*; D008107:Liver Diseases / Q000382:microbiology*; D051379:Mice; D018345:Mice, Knockout; D016692:Receptors, Antigen, T-Cell, gamma-delta; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D020381:Interleukin-17; D016692:Receptors, Antigen, T-Cell, gamma-delta; D007371:Interferon-gamma