Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling.
Post-translational protein modifications are involved in all functions of living cells. This includes the ability of cells to recognize pathogens and regulate genes involved in their clearance, a concept known as innate immunity. While phosphorylation mechanisms play essential roles in regulating different aspects of the innate immune response, ubiquitination is now recognized as another post-translational modification that works in parallel with phosphorylation to orchestrate the final proper innate immune response against invading pathogens. More precisely, this review will discuss the most recent advances that address the role of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling.
Bibeau-Poirier
Annie
A
Faculté de Pharmacie, Université de Montréal, CP 6128, succursale Centre-Ville, Montréal, Québec, Canada.
Servant
Marc J
MJ
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D000818:Animals; D004268:DNA-Binding Proteins; D000074749:Deubiquitinating Enzyme CYLD; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology; D011499:Protein Processing, Post-Translational / Q000502:physiology; D053633:Receptor, Interferon alpha-beta / Q000502:physiology*; D051192:Receptors, Pattern Recognition / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Q000502:physiology; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3; D025521:Tumor Suppressor Proteins / Q000502:physiology; D044767:Ubiquitin-Protein Ligases / Q000502:physiology; D054875:Ubiquitination / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D051192:Receptors, Pattern Recognition; C114030:TRAT1 protein, human; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; D025521:Tumor Suppressor Proteins; D053633:Receptor, Interferon alpha-beta; C458527:RNF216 protein, human; D044767:Ubiquitin-Protein Ligases; C409984:CYLD protein, human; D000074749:Deubiquitinating Enzyme CYLD; C076529:TNFAIP3 protein, human; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3