AMIN domains have a predicted role in localization of diverse periplasmic protein complexes.
We describe AMIN (Amidase N-terminal domain), a novel protein domain found specifically in bacterial periplasmic proteins. AMIN domains are widely distributed among peptidoglycan hydrolases and transporter protein families. Based on experimental data, contextual information and phyletic profiles, we suggest that AMIN domains mediate the targeting of periplasmic or extracellular proteins to specific regions of the bacterial envelope.
de Souza
Robson Francisco
RF
Departamento de Bioquímica, Universidade de São Paulo, São Paulo, Brazil.
Anantharaman
Vivek
V
de Souza
Sandro José
SJ
Aravind
L
L
Gueiros-Filho
Frederico J
FJ
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000032:analysis / Q000737:chemistry*; D008957:Models, Genetic; D008969:Molecular Sequence Data; D033903:Periplasmic Proteins / Q000032:analysis / Q000737:chemistry*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment
D001426:Bacterial Proteins; D033903:Periplasmic Proteins