The use of capsaicin in loin pain-haematuria syndrome.
OBJECTIVE
To highlight the implications of the use of capsaicin in managing loin pain-haematuria syndrome (LPHS).


METHODS
Between February 2002 and February 2007, three patients (one male and two females; mean age 31.7 years) with LPHS were managed with capsaicin and followed up for a period of 8-48 months. All were diagnosed with LPHS after negative urological investigations including urine culture, urine cytology, renal tract ultrasonography, intravenous urography and flexible cystoscopy; and nephrological work-ups including normal blood pressure measurements, creatinine clearance, urinary protein estimation and serum urea/creatinine. Five original papers were reviewed in detail for this article. Including our own experience, a total of 52 (including five bilateral) cases of LPHS treated with capsaicin are reviewed.


RESULTS
Our patients received a total of four capsaicin instillations producing an average duration of pain relief per instillation of 17 weeks. There was evidence of renal deterioration in one, while another had worsened symptoms. The third patient continued his pain management within the pain clinic. The former two patients eventually underwent nephrectomy for poor function and extreme symptoms.


CONCLUSIONS
Intrarenal capsaicin at best produces only short-term pain relief in more than half of patients with LPHS. It produces significant side-effects, i.e. UTI, bladder pain, and in up to half of patients, deteriorating symptoms. Further loss of functional renal tissue and a nephrectomy rate of 20-67% should be weighed against the benefits. We have therefore abandoned its use in treating LPHS or renal pain, and recommend that patients should be adequately counselled on its potential side-effects, including nephrotoxicity and increased nephrectomy rate.
Uzoh
Christopher C
CC
Department of Urology, Bristol Royal Infirmary, Bristol, UK. chrisc_uzoh@yahoo.com
Kumar
Vivekanandan
V
Timoney
Anthony G
AG
D000328:Adult; D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use*; D002211:Capsaicin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006417:Hematuria / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D009392:Nephrectomy / Q000379:methods*; D017699:Pelvic Pain / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D012189:Retrospective Studies; D016896:Treatment Outcome; D014463:Ultrasonography; D055815:Young Adult
D000700:Analgesics; D002211:Capsaicin