title: A polygenic model with common variants may predict lung adenocarcinoma risk in humans.
abstract: Genome-wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single-nucleotide polymorphism (SNP) array, in a joint analysis of 2 Italian case-control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6-0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population.
authors: Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy.
authors: Antonella
authors: A
authors: Galvan
authors: Felicia S
authors: FS
authors: Falvella
authors: Monica
authors: M
authors: Spinola
authors: Elisa
authors: E
authors: Frullanti
authors: Vera P
authors: VP
authors: Leoni
authors: Sara
authors: S
authors: Noci
authors: Maria R
authors: MR
authors: Alonso
authors: Anna
authors: A
authors: Zolin
authors: Elena
authors: E
authors: Spada
authors: Silvano
authors: S
authors: Milani
authors: Ugo
authors: U
authors: Pastorino
authors: Matteo
authors: M
authors: Incarbone
authors: Luigi
authors: L
authors: Santambrogio
authors: Anna
authors: A
authors: Gonzalez Neira
authors: Tommaso A
authors: TA
authors: Dragani
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D002874:Chromosome Mapping; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012907:Smoking