Pelvic perfusion for advanced colorectal cancers.
Isolated pelvic perfusion (IPP) is a form of intra-arterial local-regional treatment of tumor-bearing organs. IPP using a simplified balloon occlusion technique has shown promise in palliation of resectability of advanced rectal cancer in patients not amenable to treatment with conventional chemoradiation. This article reviews technique criteria and the response to IPP from seven literature studies of isolated pelvic perfusion with colorectal cancer. Current efforts should be directed to improving anti-tumor responses by optimizing chemotherapeutic protocols and modifying perfusion parameters, so that hopefully, this will lead to a more standardized and improved procedure for the isolated pelvic perfusion technique.
Begossi
Giovanni
G
Roger Williams Medical Center, Boston University School of Medicine, 825 Chalkstone Avenue, Providence, RI 02908, USA.
Belliveau
James F
JF
Wanebo
Harold J
HJ
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000266:history; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000266:history / Q000379:methods*; D002986:Clinical Trials as Topic; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D049673:History, 20th Century; D006801:Humans; D010386:Pelvic Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents