title: [Combined squamous cell carcinoma and malignant melanoma of the eyelid].
abstract: We present a case report of co-existent components of squamous cell carcinoma and malignant melanoma within a solid eyelid tumour in a 74-year-old male. The particular composite of these two malignancies in ocular adnexa is to the best of our knowledge reported for the first time. The histological findings exhibited a solid anterior lid tumour infiltrating the skin and surrounding conjunctiva, as well as the orbicular muscles. The hyper- and parakeratotic keratin-rich squamous cell carcinoma was cytokeratin AE1/AE3 positive, had a slight atypia but an obvious invasion in the depth. Between the squamous cell carcinoma cells were islands of HMB45 and Melan-A positive melanoma cells with slight pigmentation, which demonstrated not only subcutaneous but also intraepithelial invasion.
authors: Universitätsaugenklinik Freiburg. jing.hua@bristol.ac.uk
authors: J
authors: J
authors: Hua
authors: C
authors: C
authors: Auw-Hädrich
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis*; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*