Detection of HLA-antibodies prior to renal transplantation: prospects and limitations of new assays.
Donor-specific HLA antibodies are responsible for most early renal allograft rejections and allograft losses. Therefore, detection of HLA antibodies prior to transplantation is an important step in the evaluation of renal allograft recipients. In this mini-review we will describe recent advances in the techniques used to detect donor-specific HLA antibodies with emphasis on their potential application for patient management and their current limitations.
Amico
Patrizia
P
Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.
Hönger
Gideon
G
Mayr
Michael
M
Schaub
Stefan
S
D005434:Flow Cytometry; D006084:Graft Rejection / Q000517:prevention & control*; D006680:HLA Antigens / Q000097:blood*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*
D006680:HLA Antigens