title: Response to pneumococcal (PNCRM7) and haemophilus influenzae conjugate vaccines (HIB) in pediatric and adult recipients of an allogeneic hematopoietic cell transplantation (alloHCT).
abstract: Young children and allogeneic hematopoietic cell transplantation (HCT) recipients respond poorly to polysaccharide antigens, rendering them susceptible to severe infections because of encapsulated bacteria. This study evaluated the responses of 127 HCT patients, median age 23.0 years, vaccinated with PNCRM7 and Haemophilus influenzae (HIB) conjugate, 2 conjugate vaccines highly immunogenic in healthy children. Median time to vaccination was 1.1 years after HCT. Sixty-two percent of patients responded to PNCRM7 (45 of 51 children, 34 of 76 adults, P < .001). Overall response to HIB was 86%, including 77% of PNCRM7 nonresponders. Although PNCRM7 response was adversely affected by older age (P < .001), individuals > or =50 years old responded significantly better if vaccinated following acquisition of specific minimal milestones of immune competence, CD4 >200/microL, IgG >500 mg/dL, PHA within 60% lower limit of normal (11 of 19 versus 0 of 8, P < .006). A similar trend was observed in patients with limited chronic graft-versus-host disease (cGVHD). In all patients, higher levels of circulating CD4(+)CD45RA cells correlated with improved PNCRM7 response. These data demonstrate that PNCRM7 is immunogenic in allogeneic HCT patients, including older adults, but suggest that vaccination at fixed intervals after HCT, irrespective of immune competence, may limit its effectiveness. Prospective, multicenter trials assessing the best strategy to administer this vaccine and its impact on pneumococcal infections following transplantation are warranted.
authors: Memorial Sloan Kettering, New York, New York.
authors: Mary
authors: M
authors: Pao
authors: Memorial Sloan Kettering, New York, New York.
authors: Esperanza B
authors: EB
authors: Papadopoulos
authors: Memorial Sloan Kettering, New York, New York.
authors: Joanne
authors: J
authors: Chou
authors: Memorial Sloan Kettering, New York, New York.
authors: Heller
authors: H
authors: Glenn
authors: Memorial Sloan Kettering, New York, New York.
authors: Hugo
authors: H
authors: Castro-Malaspina
authors: Memorial Sloan Kettering, New York, New York.
authors: Ann A
authors: AA
authors: Jakubowski
authors: Memorial Sloan Kettering, New York, New York.
authors: Nancy A
authors: NA
authors: Kernan
authors: Memorial Sloan Kettering, New York, New York.
authors: Miguel A
authors: MA
authors: Perales
authors: Memorial Sloan Kettering, New York, New York.
authors: Susan
authors: S
authors: Prokop
authors: Memorial Sloan Kettering, New York, New York.
authors: Andromachi
authors: A
authors: Scaradavou
authors: Memorial Sloan Kettering, New York, New York.
authors: Marcel R
authors: MR
authors: vanDenBrink
authors: Memorial Sloan Kettering, New York, New York.
authors: James W
authors: JW
authors: Young
authors: Memorial Sloan Kettering, New York, New York.
authors: Richard J
authors: RJ
authors: O'Reilly
authors: Memorial Sloan Kettering, New York, New York. Electronic address: small@MSKCC.ORG.
authors: Trudy N
authors: TN
authors: Small
mesh_terms: D000293:Adolescent; D000328:Adult; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology / Q000401:mortality; D018073:Haemophilus Vaccines / Q000008:administration & dosage* / Q000276:immunology; D019337:Hematologic Neoplasms / Q000276:immunology / Q000401:mortality / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D008297:Male; D022401:Meningococcal Vaccines / Q000008:administration & dosage* / Q000276:immunology; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011008:Pneumococcal Infections / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000276:immunology; D011446:Prospective Studies; D020127:Recovery of Function / Q000187:drug effects* / Q000276:immunology; D012189:Retrospective Studies; D014184:Transplantation, Homologous; D014611:Vaccination
chemical_list: D018073:Haemophilus Vaccines; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines