title: Solitary peripheral ciliated glandular papillomas of the lung: a report of 3 cases.
abstract: We report 3 cases of solitary papillomas located in peripheral regions of the lung that are extremely rare in the literature. The patients were 75-year-old and 72-year-old men and a 53-year-old woman. One patient complained of recurrent hemoptysis. The other 2 had no symptoms, but abnormal nodular shadows were revealed by chest radiographs during a health check. The maximum diameters of the tumors were 1.0, 1.4, and 1.1 cm, respectively. The 3 tumors gave almost the same histologic findings. Papillomatous fronds lined by a stratified columnar epithelium were seen in the lumens of peripheral bronchi, bronchioles, or alveoli. The stratified columnar epithelium consisted of ciliated, mucous, and basal cells. The neoplastic epithelium extended to the alveolar region and showed a similar appearance to bronchioloalveolar or papillary type adenocarcinomas. For differential diagnosis, it is noteworthy that endobronchiolar papillomatous fronds constantly exist and spreading along alveolar walls is limited in adjacent alveoli in peripheral papillomas. The presence of ciliated cells and basal cells is considered an important finding to suggest benign character of the lesion.
authors: Department of Laboratory Medicine, National Defense Medical College Hospital, Tokorozawa, Saitama, Japan. aidas@ndmc.ac.jp
authors: Shinsuke
authors: S
authors: Aida
authors: Ichiyo
authors: I
authors: Ohara
authors: Hideyuki
authors: H
authors: Shimazaki
authors: Yuichi
authors: Y
authors: Dai
authors: Sho
authors: S
authors: Ogata
authors: Yuichi
authors: Y
authors: Ozeki
authors: Seiichi
authors: S
authors: Tamai
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000473:pathology*; D000368:Aged; D001980:Bronchi / Q000473:pathology; D001984:Bronchial Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D002923:Cilia / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology* / Q000648:ultrastructure; D010212:Papilloma / Q000473:pathology* / Q000648:ultrastructure; D011650:Pulmonary Alveoli / Q000473:pathology; D020545:Respiratory Mucosa / Q000473:pathology; D003074:Solitary Pulmonary Nodule / Q000473:pathology* / Q000648:ultrastructure