Centrosomes: keeping tumors in check.
Centrosomal abnormalities have been observed in a wide range of tumors, but it is not clear whether these abnormalities alone can induce cancer formation or whether they are a consequence of cancer progression. Recent work in Drosophila suggests that centrosome defects in asymmetrically dividing cells can induce tumors at a higher frequency than other conditions known to cause genomic instability.
Pelletier
Laurence
L
Samuel Lunenfeld Research Institute, Toronto, Ontario M5G 1X5, Canada.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D018385:Centrosome / Q000473:pathology*; D004330:Drosophila; D042822:Genomic Instability; D009369:Neoplasms / Q000473:pathology*