title: The H19 locus acts in vivo as a tumor suppressor.
abstract: The H19 locus belongs to a cluster of imprinted genes that is linked to the human Beckwith-Wiedemann syndrome. The expression of H19 and its closely associated IGF2 gene is frequently deregulated in some human tumors, such as Wilms' tumors. In these cases, biallelic IGF2 expression and lack of expression of H19 are associated with hypermethylation of the imprinting center of this locus. These observations and others have suggested a potential tumor suppressor effect of the H19 locus. Some studies have also suggested that H19 is an oncogene, based on tissue culture systems. We show, using in vivo murine models of tumorigenesis, that the H19 locus controls the size of experimental teratocarcinomas, the number of polyps in the Apc murine model of colorectal cancer and the timing of appearance of SV40-induced hepatocarcinomas. The H19 locus thus clearly displays a tumor suppressor effect in mice.
authors: Department of Genetics and Development, Institut Cochin, University Paris Descartes, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Institut National de la Santé et de la Recherche Médicale U567, Paris 75014, France.
authors: Tomomi
authors: T
authors: Yoshimizu
authors: Audrey
authors: A
authors: Miroglio
authors: Marie-Anne
authors: MA
authors: Ripoche
authors: Anne
authors: A
authors: Gabory
authors: Maria
authors: M
authors: Vernucci
authors: Andrea
authors: A
authors: Riccio
authors: Sabine
authors: S
authors: Colnot
authors: Cécile
authors: C
authors: Godard
authors: Benoit
authors: B
authors: Terris
authors: Hélène
authors: H
authors: Jammes
authors: Luisa
authors: L
authors: Dandolo
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D015179:Colorectal Neoplasms / Q000473:pathology; D004195:Disease Models, Animal; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D007335:Insulin-Like Growth Factor II; D051379:Mice; D008817:Mice, Mutant Strains; D005810:Multigene Family; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000145:classification / Q000502:physiology*; D013724:Teratoma / Q000473:pathology
chemical_list: C094335:H19 long non-coding RNA; C513121:IGF2 protein, mouse; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D007335:Insulin-Like Growth Factor II