title: Inflammatory myofibroblastic tumors of the genitourinary tract--single entity or continuum?
abstract: OBJECTIVE
  Inflammatory myofibroblastic tumor of the genitourinary tract is a spindled soft tissue lesion that is often mistaken for sarcoma. These tumors have been described in numerous sites in the body and have been assigned many names. The relationship between inflammatory myofibroblastic tumor and other morphologically similar entities has been a long-standing source of controversy. We investigated whether inflammatory myofibroblastic tumors in adults and children are the same entity, and whether inflammatory myofibroblastic tumor is part of a biological spectrum that includes benign and malignant entities at opposite ends.
  
  
  METHODS
  We performed an extensive review of the literature.
  
  
  RESULTS
  The literature suggests that with evidence of anaplastic lymphoma kinase rearrangement and expression, the lesion is neoplastic rather than reactive, differentiating it from previously described lesions.
  
  
  CONCLUSIONS
  Inflammatory myofibroblastic tumor of the genitourinary tract should be considered a neoplasm of uncertain malignant potential, and routine surveillance and close clinical followup are recommended. Aggressive therapy (radical cystectomy, radiation or chemotherapy) is unwarranted given the indolent and often benign clinical course for the majority of cases. To understand the diagnostic and prognostic implications future emphasis should be placed on the link between genetic abnormalities, and clinical course, therapeutic response and ultimate outcome.
authors: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. liang_cheng@yahoo.com
authors: Liang
authors: L
authors: Cheng
authors: Stephanie R
authors: SR
authors: Foster
authors: Gregory T
authors: GT
authors: MacLennan
authors: Antonio
authors: A
authors: Lopez-Beltran
authors: Shaobo
authors: S
authors: Zhang
authors: Rodolfo
authors: R
authors: Montironi
mesh_terms: D001707:Biopsy, Needle; D002277:Carcinoma / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D003937:Diagnosis, Differential; D006104:Granuloma, Plasma Cell / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D009367:Neoplasm Staging; D011379:Prognosis; D018570:Risk Assessment; D012509:Sarcoma / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D014516:Ureteral Neoplasms / Q000175:diagnosis / Q000473:pathology; D014523:Urethral Neoplasms / Q000175:diagnosis / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000473:pathology; D014565:Urogenital Neoplasms / Q000175:diagnosis / Q000473:pathology*