title: Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease.
abstract: Veno-occlusive disease (VOD) of the liver is a severe complication of high-dose chemotherapy and allogeneic or autologous stem cell transplantation with potential fatal outcome. We report a case of severe VOD in a patient with a high-grade B-cell lymphoma. Liver-venule occlusion was confirmed by liver biopsy. Supportive care, fibrinolytic treatment with recombinant tissue plasminogen activator and defibrotide maintenance therapy led to complete resolution of VOD demonstrated at liver biopsy and with a follow-up of 44 months after autologous peripheral blood stem cell transplantation. The literature on VOD has been reviewed.
authors: Department of Hematology, Catholic University of Sacred Heart, Faculty of Medicine, Rome, Italy.
authors: Mariangela
authors: M
authors: Palladino
authors: Luca
authors: L
authors: Miele
authors: Maurizio
authors: M
authors: Pompili
authors: Alessandra
authors: A
authors: Forgione
authors: Valerio
authors: V
authors: Vellone
authors: Fabio M
authors: FM
authors: Vecchio
authors: Patrizia
authors: P
authors: Chiusolo
authors: Luca
authors: L
authors: Laurenti
authors: Giovanni
authors: G
authors: Gasbarrini
authors: Simona
authors: S
authors: Sica
authors: Antonio
authors: A
authors: Grieco
mesh_terms: D000328:Adult; D052157:Aptamers, Nucleotide / Q000627:therapeutic use; D001706:Biopsy; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006504:Hepatic Veno-Occlusive Disease / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000628:therapy*; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D011089:Polydeoxyribonucleotides / Q000627:therapeutic use; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D014182:Transplantation, Autologous
chemical_list: D052157:Aptamers, Nucleotide; D005343:Fibrinolytic Agents; D011089:Polydeoxyribonucleotides; C036901:defibrotide; D010959:Tissue Plasminogen Activator