Comparative rates of freeze-drying for lactose and sucrose solutions as measured by photographic recording, product temperature, and heat flux transducer.
Sublimation from lactose and sucrose solutions has been monitored by temperature measurement, visual observation, heat flux sensing and manometric measurements. Estimates of energy transfer rates to the subliming mass made from visual observations and heat flux measurements are in broad agreement, demonstrating for the first time that heat flux sensors can be used to monitor the progress of lyophilization in individual vials with low sample volumes. Furthermore, it is shown that under identical lyophilization conditions the initial rate of drying for lactose solutions is low with little water sublimation for up to 150 minutes, which contrasts markedly with the much faster initial rate of drying for sucrose solutions. Measurement of the initial heat flux between shelf and vial indicated a lower flux to a 10% lactose solution than to a 10% sucrose solution.
Chen
Rongjun
R
Department of Chemical Engineering, University of Cambridge, Cambridge, UK.
Slater
Nigel K H
NK
Gatlin
Larry A
LA
Kramer
Tony
T
Shalaev
Evgenyi Y
EY
D002626:Chemistry, Pharmaceutical / Q000379:methods; D005612:Freeze Drying; D006358:Hot Temperature; D007785:Lactose / Q000737:chemistry*; D019999:Pharmaceutical Solutions; D010781:Photography / Q000379:methods; D013395:Sucrose / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors; D014159:Transducers; D014867:Water / Q000737:chemistry
D019999:Pharmaceutical Solutions; D014867:Water; D013395:Sucrose; D007785:Lactose