Antibacterial activity of halogenated sesquiterpenes from Malaysian Laurencia spp.
During our studies on Malaysian Laurencia species, brominated metabolites, tiomanene, acetylmajapolene B, and acetylmajapolene A were isolated from an unrecorded species collected at Pulau Tioman, Pahang along with known majapolene B and majapolene A. Acetylmajapolene A was a mixture of diastereomers as in the case of majapolene A. Tiomanene may be a plausible precursor for acetylmajapolenes B and A. In addition, three known halogenated sesquiterpenes and two known halogenated C(15) acetogenins were found from other two unrecorded species collected at Pulau Karah, Terengganu and Pulau Nyireh, Terengganu, respectively. Some of these halogenated metabolites showed moderate antibacterial activity against some marine bacteria.
Vairappan
Charles Santhanaraju
CS
Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Locked Bag 2073, 88999 Kota Kinabalu, Sabah, Malaysia. csv@ums.edu.my
Suzuki
Minoru
M
Ishii
Takahiro
T
Okino
Tatsufumi
T
Abe
Tsuyoshi
T
Masuda
Michio
M
D000107:Acetylation; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002861:Chromobacterium / Q000187:drug effects; D004885:Erwinia / Q000187:drug effects; D054879:Halogenation; D044722:Laurencia / Q000737:chemistry*; D008296:Malaysia; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011511:Proteus / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014733:Vibrio / Q000187:drug effects
D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes