[Resistance to antiplatelet drugs in patients with non ST elevation acute coronary syndrome].
Rate of resistance to aspirin and clopidogrel was assessed in 44 patients with non ST elevation acute coronary syndrome. Platelet aggregation was studied by method of Born. Criterion of resistance to aspirin was arachidonic acid induced aggregation > or =20%. Patients with lowering of ADP induced aggregation < 10%, 10 - 29% and 30% relative to initial level were considered resistant, partially resistant, and sensitive to therapy with clopidogrel, respectively. It was shown that rate of resistance to aspirin, clopidogrel, and both drugs reached 25.7, 17.1, and 5.7%, respectively.
Aĭnetdinova
D Kh
DKh
Udovichenko
A E
AE
Sulimov
V A
VA
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000627:therapeutic use; D000077144:Clopidogrel; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004351:Drug Resistance; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013577:Syndrome; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D016896:Treatment Outcome
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin