Hemostasis abnormalities in liver cirrhosis: myth or reality?
Chronic liver disease is characterized by a global hemostatic defect that includes platelet-vessel wall interaction (primary hemostasis), fibrinolysis and coagulation causing abnormalities of the relevant laboratory tests. The causal relationship between abnormal tests and bleeding has been widely accepted, despite the fact that abnormal tests are poorly associated with bleeding. Recent evidence from the literature disputes the above paradigm and open new directions for laboratory and clinical research in this field.
Tripodi
Armando
A
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University Medical School and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milano, Italy. armando.tripodi@unimi.it
D035843:Biomedical Research; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D002908:Chronic Disease; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000150:complications*; D008111:Liver Function Tests; D010974:Platelet Aggregation; D013917:Thrombin / Q000096:biosynthesis; D019851:Thrombophilia / Q000209:etiology
D013917:Thrombin