Two new triterpenoid saponins from Gymnema sylvestre.
Two new oleanane-type triterpenoid saponins, gymnemoside-W1 and W2, together with seven known compounds were isolated from the leaves of Gymnema sylvestre R. Br. By means of spectral and chemical analysis, the structures of the new compounds were elucidated as 16 beta-hydroxyl olean-12-en-3-O-[beta-D-glucopyranosyl (1-->6)-beta-D-glucopyranosyl]-28-O-beta-D-glucopyranoside(1) and 16 beta,21 beta,28-trihydroxyl-olean-12-ene-3-O-glucoronopyranoside (2). The EtOH/H(2)O extracts of this plant were shown to be able to inhibit glucose absorption in rats.
Zhu
Xu-Min
XM
Chengdu Institute of Biology, the Chinese Academy of Sciences, Chengdu 610041, China.
Xie
Ping
P
Di
Ying-Tong
YT
Peng
Shu-Lin
SL
Ding
Li-Sheng
LS
Wang
Ming-Kui
MK
D000818:Animals; D031104:Gymnema sylvestre / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D012503:Saponins; D014315:Triterpenes