Synthesis and cytotoxic activity of some novel polycyclic gamma-butyrolactones.
Baeyer-Villiger oxidation of 5-aryl-7,11,11-trimethyltricyclo[5.4.0.0(3,6)]-undec-1-en-4-ones 4a-h by H(2)O(2) and formic acid in methanol yields mixtures of 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro-1H-indeno-[1,2-c]furan-1-ones 8a-h and 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro-1H-indeno-[1,2-c]furan-2-ones 9a-h in high yields. The obtained butyrolactones 8a-h display cytotoxic activity against a number of human cancer cells.
Ishar
M P S
MP
Bio-Organic and Photochemistry Laboratory, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143 005, India.
Raj
Tilak
T
Agrawal
Satyam Kumar
SK
Saxena
A K
AK
Singh
Lakhwinder
L
Singh
Rajinder
R
Bhella
Surinderjit Singh
SS
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000633:toxicity*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000633:toxicity; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006131:Growth Inhibitors / Q000138:chemical synthesis* / Q000633:toxicity; D006801:Humans; D008297:Male; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000633:toxicity*
D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D011083:Polycyclic Compounds; D015107:4-Butyrolactone