title: Implementation of evidence-based practices for surgical site infection prophylaxis: results of a pre- and postintervention study.
abstract: BACKGROUND
  Although evidence-based guidelines for best practices pertaining to surgical site infection (SSI) prophylaxis exist, the feasibility of implementing such practices remains to be demonstrated outside of a controlled clinical trial. This study was designed to assess the safety and feasibility of implementing evidence-based care practices to prevent SSIs.
  
  
  METHODS
  A prospective, double-cohort (pre- and postintervention) trial in elective, general surgery patients was conducted. All patients undergoing elective, major colorectal or hepatobiliary operations were enrolled. Postintervention cohort patients were exposed to new strategies to improve antibiotic administration times, perioperative normothermia rates, and perioperative glucose control. They were compared with the preintervention cohort, which received standard practice at the time. Outcomes evaluated include timing of antibiotic administration, perioperative temperatures, and postoperative glucose levels. SSI rates between cohorts were also compared.
  
  
  RESULTS
  A total of 208 patients were enrolled. The proportion of patients receiving their preoperative antibiotics within 60 minutes improved from 5.9% to 92.6% (p < 0.001); perioperative normothermia rates improved from 60.5% to 97.6% (p < 0.001) between cohorts. There was no improvement in rates of hyperglycemia. SSI rates improved but did not reach statistical significance (14.3% versus 8.7%; p = 0.21).
  
  
  CONCLUSIONS
  Implementation of evidence-based care practices to prevent SSI is both safe and practical outside the setting of a randomized, controlled trial. Sustained compliance remains to be demonstrated, although practice audits at our institution suggest ongoing success is possible.
authors: Department of Surgery, Division of General Surgery, McMaster University, Hamilton, Ontario, Canada.
authors: Shawn S
authors: SS
authors: Forbes
authors: Wesley J
authors: WJ
authors: Stephen
authors: William L
authors: WL
authors: Harper
authors: Mark
authors: M
authors: Loeb
authors: Rhonda
authors: R
authors: Smith
authors: Emily P
authors: EP
authors: Christoffersen
authors: Richard F
authors: RF
authors: McLean
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D019072:Antibiotic Prophylaxis; D001786:Blood Glucose / Q000378:metabolism; D001831:Body Temperature; D015331:Cohort Studies; D003082:Colectomy; D004334:Drug Administration Schedule; D019317:Evidence-Based Medicine; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010043:Outcome and Process Assessment, Health Care; D011182:Postoperative Care; D011300:Preoperative Care; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D001786:Blood Glucose