Time series analysis of treatment adherence patterns in individuals with obstructive sleep apnea.
BACKGROUND
Adherence to medical recommendations is often suboptimal, making examination of adherence data an important scientific concern. Studies that attempt to predict or modify adherence often face the problem that adherence as a dependent variable is complex and non-normally distributed. Traditional statistical approaches to adherence data may mask individual variability that may guide clinician and researcher's development of adherence interventions. In this study, we employ time series analysis to examine adherence patterns objectively in patients with obstructive sleep apnea (OSA). Although treatment adherence is poor in OSA, state-of-the-art adherence monitoring allows a comprehensive examination of objective data.


OBJECTIVE
The purpose of the study is to determine the number and types of adherence patterns seen in a sample of patients with OSA receiving positive airway pressure (PAP).


METHODS
Seventy-one moderate to severe OSA participants with 365 days of treatment data were studied.


RESULTS
Adherence patterns could be classified into seven categories: (1) Good Users (24%), (2) Slow Improvers (13%), (3) Slow Decliners (14%), (4) Variable Users (17%), (5) Occasional Attempters (8%), (6) Early Drop-outs (13%), and (7) Non-Users (11%).


CONCLUSIONS
Time series analysis provides a useful method for examining adherence while maintaining a focus on individual differences. Implications for future research are discussed.
Aloia
Mark S
MS
Brown Medical School, Providence, RI, USA. aloiam@njc.org
Goodwin
Matthew S
MS
Velicer
Wayne F
WF
Arnedt
J Todd
JT
Zimmerman
Molly
M
Skrekas
Jaime
J
Harris
Sarah
S
Millman
Richard P
RP
D000328:Adult; D001519:Behavior; D005260:Female; D006184:Habits; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000523:psychology*; D010363:Pattern Recognition, Automated; D017286:Polysomnography; D011175:Positive-Pressure Respiration; D020181:Sleep Apnea, Obstructive / Q000523:psychology / Q000628:therapy*; D013997:Time Factors