title: Primary hepatic neuroendocrine carcinoma in a baboon (Papio sp.).
abstract: BACKGROUND
  Primary neuroendocrine carcinomas of the liver have rarely been reported in humans and domestic animals, but not in non-human primates.
  
  
  METHODS
  We describe the morphologic and immunohistochemical features of a primary hepatic neuroendocrine carcinoma found in a 29-year-old female baboon.
  
  
  CONCLUSIONS
  The neoplasm was characterized by multiple solid nodules that were multifocally distributed in the liver. Metastases were not observed. Histologically, the neoplasm was composed of cords and nests of epithelial cells arranged in a neuroendocrine pattern, occasionally forming glandular and rosette-like structures. On immunohistochemical evaluation, the neoplastic cells were immunopositive for pancytokeratin, chromogranin A, neuron-specific endolase, and synaptophysin and were negative for vimentin, S100 protein, glucagon, and insulin.
authors: Department of Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX, USA.
authors: Fabio
authors: F
authors: Aloisio
authors: Edward J
authors: EJ
authors: Dick
authors: Gene B
authors: GB
authors: Hubbard
mesh_terms: D000818:Animals; D018278:Carcinoma, Neuroendocrine / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology / Q000662:veterinary*; D008992:Monkey Diseases / Q000473:pathology*; D010215:Papio