title: Paclitaxel- and platinum-based postoperative chemotherapy for primary fallopian tube carcinoma: a single institution experience.
abstract: BACKGROUND
  Primary fallopian tube carcinoma (PFTC) is a rare gynecologic malignancy with very few data existing on the activity of the combination of paclitaxel with a platinum analogue as adjuvant chemotherapy.
  
  
  METHODS
  We retrospectively analyzed 41 consecutive patients with PFTC who were treated postoperatively with paclitaxel- and platinum-containing chemotherapy regimens.
  
  
  RESULTS
  We observed 12 (63.2%) complete and 6 (31.6%) partial responses among 19 patients with measurable disease. The median time to disease progression (TTP) for all patients was 68 months. The median overall survival (OS) for all patients has not been reached yet. The median TTP was 84 months for patients with stage I/II disease and 34 months for patients with advanced disease (p = 0.017). Median OS has not been reached yet for patients with stage I/II PFTC, while it was 63.8 months for patients with stage III/IV disease (p = 0.002). Furthermore, OS has not been reached yet for patients with optimally debulked tumors, while it was 34.1 months for patients with residual disease >2 cm (p < 0.0001).
  
  
  CONCLUSIONS
  Adjuvant platinum- and paclitaxel-based chemotherapy should be regarded as the standard treatment in patients with PFTC. Early stage disease and optimal debulking are associated with improved TTP and OS.
authors: Department of Clinical Therapeutics, Alexandra Hospital, Athens, Greece. chr_papadim@yahoo.gr
authors: Christos A
authors: CA
authors: Papadimitriou
authors: Panagiotis
authors: P
authors: Peitsidis
authors: George
authors: G
authors: Bozas
authors: Irene
authors: I
authors: Grimani
authors: George
authors: G
authors: Vlahos
authors: Alexandros
authors: A
authors: Rodolakis
authors: Evangelos
authors: E
authors: Lianos
authors: Aristotelis
authors: A
authors: Bamias
authors: George
authors: G
authors: Lainakis
authors: Meletios-A
authors: MA
authors: Dimopoulos
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D005185:Fallopian Tube Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D017671:Platinum Compounds / Q000008:administration & dosage; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D017671:Platinum Compounds; D017239:Paclitaxel