HIV-1 infection: going nuclear with TNPO3/Transportin-SR2 and integrase.
Factors necessary for HIV-1 nuclear import have been sought for many years. Recent reports suggest that TNPO3/Transportin-SR2 binds to HIV-1 integrase and is required for HIV-1 infection of interphase cells.
Luban
Jeremy
J
Department of Microbiology and Molecular Medicine, University of Geneva, CH-1211 Geneva 4, Switzerland. jeremy.luban@unige.ch
D002467:Cell Nucleus / Q000378:metabolism / Q000821:virology*; D019427:HIV Integrase / Q000378:metabolism*; D015497:HIV-1 / Q000378:metabolism* / Q000502:physiology; D014779:Virus Replication; D028961:beta Karyopherins / Q000378:metabolism*
D028961:beta Karyopherins; C424165:transportin SR2; D019427:HIV Integrase; C514801:p31 integrase protein, Human immunodeficiency virus 1