Matrix metalloproteinase-2 gene polymorphisms in nasal polyps.
OBJECTIVE
To systematically investigate the role of matrix metalloproteinase-2 (MMP2) tagging single nucleotide polymorphisms (SNPs) and promoter functional polymorphism in the development of nasal polyps in a Chinese population in Taiwan.


METHODS
We conducted a case-control study in 136 cases of chronic rhinosinusitis with bilateral nasal polyps and 136 controls. Seventeen SNPs were selected, including 16 tagging SNPs and 1 promoter functional SNP. The genotypes were determined by TaqMan technology. Hardy-Weinberg equilibrium was tested for each SNP, and genetic effects were evaluated according to 3 modes of inheritance. Subset analysis based on the recurrence of nasal polyps was also performed.


METHODS
Medical university center hospital.


RESULTS
All 17 SNPs were in Hardy-Weinberg equilibrium. When comparing the patients with recurrent nasal polyps and controls, none of the SNPs reached the significant level of P < .05 except rs857403. The AT genotype of rs857403 had an adjusted odds ratio of 2.07 (95% confidence interval, 1.09-3.95) (P = .03). However, the result became nonsignificant after including an additional 691 controls. Therefore, we considered that the initial significance was a false-positive finding. Neither haplotype analysis nor subset analysis yielded any significant result.


CONCLUSIONS
The MMP2 gene does not play a crucial role in conferring risk for nasal polyps in a Taiwanese population.
Wang
Ling-Feng
LF
Department of Otolaryngology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chien
Chen-Yu
CY
Kuo
Wen-Rei
WR
Tai
Chin-Feng
CF
Juo
Suh-Hang Hank
SH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002648:Child; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D008875:Middle Aged; D009298:Nasal Polyps / Q000235:genetics* / Q000601:surgery; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012008:Recurrence; D012220:Rhinitis / Q000235:genetics* / Q000601:surgery; D012852:Sinusitis / Q000235:genetics* / Q000601:surgery; D013624:Taiwan
C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2