Possible relationship between the risk of Japanese bladder cancer cases and the CYP4B1 genotype.
Cytochrome P450 4B1 (CYP4B1) is involved in the metabolism of several xenobiotics, such as 2-aminofluorene, 2-naphthylamine and benzidine. CYP4B1 allelic variants CYP4B1*1-*7 were recently identified. We thus hypothesized that CYP4B1 genotypes may modify bladder cancer risk. We examined the CYP4B1 genotypes in 169 bladder cancer cases and 190 hospital controls using a hybridization probe assay. Among the CYP4B1 genotypes observed, the most frequent genotypes in both the groups were CYP4B1*1/*1, *1/*2, *1/*3 and *2/*2. Logistic regression analysis revealed that the subjects carrying the CYP4B1*1/*2 or *2/*2 genotypes had a 1.75-fold increased risk of bladder cancer (95% CI=1.03-2.95, P = 0.038) compared with the subjects carrying the CYP4B1*1/*1 genotype. We demonstrated the first genetic study regarding the association of CYP4B1 with bladder cancer. Our results suggest that CYP4B1 genotypes might have an effect on the risk of bladder cancer.
Sasaki
Takamitsu
T
Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
Horikawa
Miho
M
Orikasa
Kazuhiko
K
Sato
Makoto
M
Arai
Yoichi
Y
Mitachi
Yoshitaka
Y
Mizugaki
Michinao
M
Ishikawa
Masaaki
M
Hiratsuka
Masahiro
M
D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D011110:Polymorphism, Genetic; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology* / Q000235:genetics*
D001189:Aryl Hydrocarbon Hydroxylases; C095029:cytochrome P-450 CYP4B1