Pathological laughter in a patient with multiple sclerosis.
Pseudobulbar affect-such as pathological laughter or crying-is associated with several different neurologic diseases and is most frequently seen in patients with Alzheimer disease. However, many physicians do not recognize it as a symptom associated with multiple sclerosis. The present report describes a case of pathological laughter in a 56-year-old man who was diagnosed as having multiple sclerosis 20 years earlier.
Hoegerl
Carl
C
Geisinger Medical Center, 100 N Academy Ave 14-05, Danville, PA 17822-0001, USA. hoegerl@yahoo.com
Zboray
Sharon
S
D001931:Brain Mapping / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D007845:Laughter / Q000523:psychology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D012307:Risk Factors; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed
D011241:Prednisone