Effect of restraint stress duration on humoral immune response in albino rats: modulation by chlordiazepoxide.
We evaluated the effect of restraint stress (1 hr/day) for 6, 10, 14 and 21 days on antibody response against sheep RBC (SRBC) and modulation by chlordiazepoxide (CDP) pretreatment (10 mg/kg/day) in albino rats. Anti-SRBC titer was significantly decreased with increase in number of days of restraint stress exposure. CDP pretreatment significantly reversed the effects of 6, 10 and 14 (but not of 21) days of restraint stress. CDP treatment for 21 days per se suppressed immune response, but no additive effect was observed. CDP was not effective in chronic stress (i.e., 21 days of stress). Hence, the rationale behind benzodiazepines therapy in chronic stress needs to be evaluated.
Suresh
Padmanaban S
PS
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Doureradjou
Peroumal
P
Nandakumar
Dalavikodihalli Nanjaiah
DN
Koner
Bidhan Chandra
BC
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002707:Chlordiazepoxide / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D056724:Immunity, Humoral / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000187:drug effects* / Q000276:immunology*
D014151:Anti-Anxiety Agents; D002707:Chlordiazepoxide