title: Subclinical idiopathic pulmonary fibrosis is also a risk factor of postoperative acute respiratory distress syndrome following thoracic surgery.
abstract: OBJECTIVE
  Postoperative acute interstitial pneumonia is a subset of post-surgical acute respiratory distress syndrome (ARDS) and is responsible for one third of in-hospital deaths following lung resection in patients with primary lung cancer. We evaluated the usefulness of computed tomography (CT) for detection of interstitial pneumonia (IP) as a risk factor of postoperative ARDS.
  
  
  METHODS
  Preoperative chest CT of patients who underwent thoracotomy for primary lung cancer was reviewed retrospectively and IP findings in the chest CT were detected.
  
  
  RESULTS
  A total of 1148 patients with primary lung cancer underwent thoracotomy. Fifteen patients (1.3%) developed postoperative ARDS. Eleven of these 15 patients died of ARDS. Three of 41 patients who received induction therapy developed postoperative ARDS. Induction therapy was a risk factor of postoperative ARDS (p<0.01). Eleven out of the 15 patients who developed postoperative ARDS had IP findings (10: localized, 1: diffuse) in their chest CT. Two of three patients who had postoperative ARDS after induction therapy also had IP findings. Chest CTs of 834 patients were retrospectively analyzed; 91 patients (10.9%) had IP-findings (diffuse 1.8%, localized 9.1%). Postoperative ARDS occurred in 8.8% of IP-positive patients, and in 0.4% of IP-negative patients (p<0.001).
  
  
  CONCLUSIONS
  Detection of IP by chest CT is useful for the selection of high-risk patients who may have postoperative ARDS following thoracotomy.
authors: Department of Chest Surgery, Clinical Chest Center, Ohta-Nishinouchi Hospital, 2-5-20 Nishinouchi, Koriyama, Fukushima 963-8558, Japan. chida-ths@umin.ac.jp
authors: Masayuki
authors: M
authors: Chida
authors: Shuichi
authors: S
authors: Ono
authors: Yasushi
authors: Y
authors: Hoshikawa
authors: Takashi
authors: T
authors: Kondo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012128:Respiratory Distress Syndrome / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D013908:Thoracotomy / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed