Signaling by synaptogenic molecules.
Multiple signaling pathways initiate and specify the formation of synapses in the central nervous system. General principles that organize nascent synapses have emerged from the studies in multiple model organisms. These include the synapse-organizing roles of dedicated synaptic adhesion molecules, synaptic signaling following receptor-ligand interactions, and the regulation of synapse formation by secreted molecules. Intracellularly, a range of effectors subsequently regulates signaling steps and cytoskeletal changes. Together, a blueprint of synapse formation is emerging into which these distinct signaling steps will need to be integrated temporally and spatially.
Biederer
Thomas
T
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. thomas.biederer@yale.edu
Stagi
Massimiliano
M
D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
D015815:Cell Adhesion Molecules