title: Stemina biomarker discovery.
abstract: Stemina Biomarker Discovery was established in 2006 to commercialize technology developed by Dr Gabriela Cezar at the University of Wisconsin (WI, USA). Stemina's cell-based assays arise from the strategic convergence of two cutting edge technologies: metabolomics and human embryonic stem (hES) cells. Stemina analyzes the small molecules secreted by hES cells and differentiated cell types such as neural and heart cells derived from hES cells by liquid chromatography mass spectrometry at its state-of-the-art facilities in Madison, WI, USA. Stemina's first technology platform has identified a dynamic set of small molecules in the extracellular secretome of hES cells secreted in response to exposure to a library of known teratogens. Alterations to small molecules in the biochemical pathway(s) of hES cells are mapped in silico to identify biomarkers of toxicity for drug screening and development in an all human system. These small human molecules may then be translated in vivo as biomarkers of toxic response and disease.
authors: Department of Animal Science at the University of Wisconsin, WI, USA. ggcezar@wisc.edu
authors: Gabriela G
authors: GG
authors: Cezar
authors: Elizabeth L R
authors: EL
authors: Donley
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001709:Biotechnology / Q000191:economics* / Q000639:trends*; D002454:Cell Differentiation; D002460:Cell Line; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation; D053595:Embryonic Stem Cells / Q000166:cytology*; D006801:Humans; D008660:Metabolism; D009206:Myocardium / Q000166:cytology; D009474:Neurons / Q000378:metabolism; D044968:Regenerative Medicine / Q000191:economics* / Q000639:trends*; D013678:Technology, Pharmaceutical / Q000639:trends; D013723:Teratogens / Q000494:pharmacology
chemical_list: D015415:Biomarkers; D013723:Teratogens