title: [Results of a prospective standardized study of 30 patients with chronic neurological and cognitive disorders after tick bites].
abstract: OBJECTIVE
  Patients with chronic neurological disorders and cognitive impairment after tick bites are difficult to manage despite standard antibiotic therapy for Lyme disease. We wanted to correctly assess the disorders.
  
  
  METHODS
  Thirty patients were hospitalized for a standardized evaluation of their disorders: clinical examination, biological and serological studies, cerebral MRI, CSF study, neurophysiological exams, and neuropsychological evaluation of cognitive functions.
  
  
  RESULTS
  Clinical and biological results were non informative. We observed significant CSF abnormalities (64%), MRI Flair pictures (41%), neurophysiological exams (47%), and cognitive evaluation (100%).
  
  
  CONCLUSIONS
  A large and standardized evaluation should be made for each patient to improve the management and probably the treatment of these complex chronic symptoms observed after tick bites.
authors: Unité de Maladies Infectieuses, Inserm U657, CHU Raymond-Poincaré, Assistance publique-Hôpitaux de Paris, Université de Versailles Saint-Quentin-en-Yvelines, 104, boulevard Raymond-Poincaré, 92380 Garches, France
authors: M O
authors: MO
authors: Roche Lanquetot
authors: F
authors: F
authors: Ader
authors: M C
authors: MC
authors: Durand
authors: R
authors: R
authors: Carlier
authors: H
authors: H
authors: Defferriere
authors: A
authors: A
authors: Dinh
authors: J L
authors: JL
authors: Herrmann
authors: D
authors: D
authors: Guillemot
authors: C
authors: C
authors: Perronne
authors: J
authors: J
authors: Salomon
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001096:Arachnid Vectors / Q000382:microbiology; D020274:Autoimmune Diseases of the Nervous System / Q000453:epidemiology / Q000209:etiology; D001733:Bites and Stings / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D003072:Cognition Disorders / Q000453:epidemiology* / Q000209:etiology; D004569:Electroencephalography; D005071:Evoked Potentials; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D020852:Lyme Neuroborreliosis / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000453:epidemiology* / Q000209:etiology; D009483:Neuropsychological Tests; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D013987:Ticks / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D002556:Cerebrospinal Fluid Proteins