title: Systemic antibiotics and tooth loss in periodontal disease.
abstract: Systemic antibiotics have been recommended for the treatment of destructive periodontal disease. Our goal was to relate antibiotic use for medical or dental reasons to subsequent tooth loss in a cohort of 12,631 persons with destructive periodontal disease. After adjustment for age, smoking, and other confounders, the dispensing of antibiotics for 1-13 days, 14-20 days, or 21 or more days was not associated with reduced tooth loss [Adjusted rate ratio (RR) = 1.0; 95% Confidence Interval (CI) = 0.8-1.1; RR = 1.2; 95% CI = 0.9-1.4, and RR =1.2, 95% CI =1.0-1.3, respectively]. Numerous subgroup analyses were consistent with these overall null findings, with two exceptions: Longer courses of tetracyclines were associated with reduced tooth loss among persons receiving periodontal care, and penicillin was associated with reduced tooth loss among persons with more severe disease. Long-term, larger randomized trials are needed to provide evidence that antibiotics reduce tooth loss when used in the management of destructive periodontal disease.
authors: University of Washington, Dental Public Health Sciences, B509, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195-7475, USA. silvajcc@u.washington.edu
authors: J
authors: J
authors: Cunha-Cruz
authors: P P
authors: PP
authors: Hujoel
authors: G
authors: G
authors: Maupome
authors: B
authors: B
authors: Saver
mesh_terms: D000900:Anti-Bacterial Agents / Q000145:classification / Q000627:therapeutic use*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015331:Cohort Studies; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013812:Therapeutics; D016388:Tooth Loss / Q000150:complications* / Q000276:immunology / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents