Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles.
The synthesis and SAR of a series of 60 substituted 2-phenoxy-5-nitrobenzonitriles (analogues of MDL-860) as inhibitors of enterovirus replication (in particular of coxsackievirus B3 (CVB 3)) are reported. Several of the analogues inhibited CVB 3 and other enteroviruses at low-micromolar concentrations.
Pürstinger
Gerhard
G
Institut für Pharmazie, Abteilung Pharmazeutische Chemie, Universität Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria. Gerhard.Puerstinger@uibk.ac.at
De Palma
Armando M
AM
Zimmerhofer
Günther
G
Huber
Simone
S
Ladurner
Sophie
S
Neyts
Johan
J
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D029822:Enterovirus B, Human / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D009570:Nitriles; C036426:2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile