Clinical significance of micrometastases detection in lymph nodes from head and neck squamous cell carcinoma.
OBJECTIVE
Study the clinical relevance of micrometastases in head and neck squamous cell carcinoma (HNSCC).


METHODS
We reviewed the outcome of 31 patients who underwent neck dissection for HNSCC with lymph node analysis by cytokeratin 19 real-time Taqman polymerase chain reaction (CK19RT-PCR) for detection of micrometastasis. Fifteen patients were N+ on histopathology (group 1) and 16 were N-; nine of these 16 patients were CK19RT-PCR positive (group 2), whereas seven were negative (group 3). Local and neck recurrences, metastases, and other tumour sites were recorded during follow-up.


RESULTS
Five patients in group 1, eight patients in group 2, and one patient in group 3 experienced a tumor-related event. N- patients in groups 2 and 3 had a different outcome (P<0.01).


CONCLUSIONS
It is suggested that CK19RTPCR detection of micrometastasis in lymph nodes could be of significant prognostic value in HNSCC, because more aggressive treatment could be indicated in these patients.
Xu
Yanan
Y
Service d'ORL et Chirurgie Cervico-Faciale, Hôpital Tenon, Paris, France.
Lefèvre
Marine
M
Périé
Sophie
S
Tao
Lei
L
Callard
Patrice
P
Bernaudin
Jean-François
JF
St Guily
Jean Lacau
JL
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D053539:Keratin-19 / Q000378:metabolism; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D053539:Keratin-19