A specific blend of intact protein rich in aspartate has strong postprandial glucose attenuating properties in rats.
Three studies were carried out to help define an optimal protein blend for use in a nutritional product for diabetic patients. To this end, we tested the effects of coinfusions of combinations of different types of carbohydrates and proteins on the postprandial glycemic plasma response in healthy rats. Expt. 1 compared the effects of administering different forms of soy protein (intact protein, its hydrolysate, or an equivalent amount of the same amino acids), all in combination with a fixed amount of glucose (Glu), on postprandial Glu and insulin plasma concentrations. Intact soy protein (SI) had stronger insulinogenic properties compared with its hydrolysate but was equally potent in reducing the postprandial Glu response. In Expt. 2, we compared the effect of replacing 50% of the SI with the whey-derived protein alpha-lactalbumin when coingested with maltodextrin as the carbohydrate source. Only the specific aspartate-rich blend of SI and alpha-lactalbumin significantly improved the postprandial Glu response. In Expt. 3, we studied the effect of using the blend of SI and alpha-lactalbumin combined with a slowly digestible carbohydrate. The protein blend was still capable of significantly decreasing the postprandial Glu response even when a slow-release carbohydrate source was included. Combining this aspartate-rich protein blend with a slow-release carbohydrate might therefore lead to a low-glycemic nutritional product beneficial for dietary management in diabetic patients.
Hageman
Robert
R
Danone Research Centre for Specialised Nutrition, 6700 CA Wageningen, The Netherlands.
Severijnen
Chantal
C
van de Heijning
Bert J M
BJ
Bouritius
Hetty
H
van Wijk
Nick
N
van Laere
Katrien
K
van der Beek
Eline M
EM
D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects*; D004044:Dietary Proteins / Q000494:pharmacology*; D019587:Dietary Supplements; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism; D008297:Male; D019518:Postprandial Period / Q000187:drug effects* / Q000502:physiology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D030262:Soybean Proteins
D001786:Blood Glucose; D004044:Dietary Proteins; D030262:Soybean Proteins; D001224:Aspartic Acid; D005947:Glucose