title: Intra-arterial chemotherapy for head and neck cancer: experiences from three continents.
abstract: Intra-arterial infusion of chemotherapy agents for cancer of the head and neck has been used for several decades. This article provides the rationale, historical background, and current state of investigations for patients treated in this manner. The experience with this route of drug delivery comes from three geographic regions: Europe, Japan, and North America. While the results of the trials have yet to establish the approach as being superior to intravenous infusions, continued research is warranted.
authors: SimmonsCooper Cancer Institute at SIU, Division of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794-9677, USA. trobbins@siumed.edu
authors: K Thomas
authors: KT
authors: Robbins
authors: Akihiro
authors: A
authors: Homma
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D010478:Chemotherapy, Cancer, Regional Perfusion; D002986:Clinical Trials as Topic; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000401:mortality; D006801:Humans
chemical_list: D000970:Antineoplastic Agents