[Significance of Forkhead Box m1b (Foxm1b) gene in cell proliferation and carcinogenesis].
Forkhead Box m1b (Foxm1b) is a subtype of the Fox transcription factor family. It is detected in all proliferative cells, but disappears when cells enter into their terminal differentiation phase. Foxm1b is closely related to hepatocellular growth, mainly through inhibiting cyclin-dependent kinase (CDK) inhibitors to influence cell proliferation. It also participates in growth hormone (GH) mediated cell multiplication, but does not induce tumors. The expression of Foxm1b has been observed in many tumor cell lines and malignant tumors, indicating that it might be an essential proto-oncogene in carcinogenesis. Furthermore, Foxm1b may take part in liver regeneration after hepatectomy, hepatic failure and liver transplantation. Foxm1b is a new potential target for the treatment human hepatic cell carcinoma (HCC).
Tang
Shuang-Yi
SY
Department of Pharmacy, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, P. R. China. tshy369@sina.com
Jiao
Yang
Y
Li
Le-Qun
LQ
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism; D000072278:Forkhead Box Protein M1; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism*; D022781:Hepatocytes / Q000378:metabolism; D019382:Human Growth Hormone / Q000494:pharmacology; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology*; D008115:Liver Regeneration / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D000090063:Proto-Oncogene Mas; D020687:cdc25 Phosphatases / Q000378:metabolism
C107585:FOXM1 protein, human; D000072278:Forkhead Box Protein M1; D051858:Forkhead Transcription Factors; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D019382:Human Growth Hormone; D050760:Cyclin-Dependent Kinase Inhibitor p27; C517008:CDC25B protein, human; D020687:cdc25 Phosphatases