title: Comparison of breath-hold and free-breathing positions of an external fiducial by analysis of respiratory traces.
abstract: An internal target volume (ITV) accounting for respiratory-induced tumor motion is best obtained using 4DCT. However, when 4DCT is not available, inspiratory/expiratory breath-hold (BH insp, BH exp) CT images have been suggested as an alternative. In such cases, an external fiducial on the abdomen can be used as a substitute for tumor motion and CT images are acquired when the marker position matches - as judged by the therapist/physicist - its positions at previously determined free-breathing (FB) respiratory extrema (FB insp, FB exp). In this study we retrospectively determined the accuracy of these matches. Free breathing 4DCT images were acquired, followed by BH insp and BH exp CT images for 25 patients with non-small-cell lung cancer. Respiration was monitored using a commercial external fiducial system, which generates positional information while CT studies are conducted. Software was written for statistically analyzing the displacement of the external fiducial during BH insp and BH exp CT acquisition and comparing these displacements with corresponding mean FB extrema positions (FB insp and FB exp, respectively) using a Student's t-test. In 72% of patients, mean positions at BH insp differed significantly from mean positions at FB insp (p < 0.05: 0.13 - 1.40 cm). In 92% of patients, mean positions at BH exp differed significantly from mean positions at FB exp (p < 0.05: 0.03 - 0.70 cm), although this difference was smaller than 0.5 cm in many cases (median = 0.34 cm). Our findings indicate that relying solely on abdominal external markers for accurate BH CT imaging in order to accurately estimate FB extrema positions may be subject to significant error.
authors: Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
authors: Sandeep
authors: S
authors: Hunjan
authors: Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
authors: George
authors: G
authors: Starkschall
authors: Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
authors: Isaac
authors: I
authors: Rosen
authors: Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
authors: Karl
authors: K
authors: Prado
authors: Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
authors: Naresh
authors: N
authors: Tolani
authors: Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
authors: Peter
authors: P
authors: Balter
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D009068:Movement; D011859:Radiography; D012119:Respiration