title: Catalytic enantioselective aldol additions of alpha-isothiocyanato imides to aldehydes.
abstract: Highly enantioselective organocatalytic aldol additions of alpha-isothiocyanato imides to aldehydes are reported. These reactions provide convenient access to enantiomerically enriched and protected beta-hydroxy-alpha-amino acids with catalyst loadings as low as 1 mol%.
authors: Department of Chemistry and Chemical Biology, Rutgers, State University of New Jersey, Piscataway, New Jersey 08854, USA.
authors: Le
authors: L
authors: Li
authors: Eric G
authors: EG
authors: Klauber
authors: Daniel
authors: D
authors: Seidel
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis*; D000596:Amino Acids / Q000138:chemical synthesis; D002384:Catalysis; D007094:Imides / Q000737:chemistry*; D017879:Isothiocyanates / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000596:Amino Acids; D007094:Imides; D017879:Isothiocyanates