The FTO gene is associated with adulthood obesity in the Mexican population.
Common polymorphisms in the fat mass and obesity-associated gene (FTO) have shown strong association with obesity in several populations. In the present study, we explored the association of FTO gene polymorphisms with obesity and other biochemical parameters in the Mexican population. We also assessed FTO gene expression levels in adipose tissue of obese and nonobese individuals. The study comprised 788 unrelated Mexican-Mestizo individuals and 31 subcutaneous fat tissue biopsies from lean and obese women. FTO single-nucleotide polymorphisms (SNPs) rs9939609, rs1421085, and rs17817449 were associated with obesity, particularly with class III obesity, under both additive and dominant models (P = 0.0000004 and 0.000008, respectively). These associations remained significant after adjusting for admixture (P = 0.000003 and 0.00009, respectively). Moreover, risk alleles showed a nominal association with lower insulin levels and homeostasis model assessment of B-cell function (HOMA-B), and with higher homeostasis model assessment of insulin sensitivity (HOMA-S) only in nonobese individuals (P (dom) = 0.031, 0.023, and 0.049, respectively). FTO mRNA levels were significantly higher in subcutaneous fat tissue of class III obese individuals than in lean individuals (P = 0.043). Risk alleles were significantly associated with higher FTO expression in the class III obesity group (P = 0.047). In conclusion, FTO is a major risk factor for obesity (particularly class III) in the Mexican-Mestizo population, and is upregulated in subcutaneous fat tissue of obese individuals.
Villalobos-Comparán
Marisela
M
Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Instituto de Investigaciones Biomédicas de la Universidad Nacional Autónoma de México, Mexico City, Mexico.
Teresa Flores-Dorantes
M
M
Teresa Villarreal-Molina
M
M
Rodríguez-Cruz
Maricela
M
García-Ulloa
Ana C
AC
Robles
Lorena
L
Huertas-Vázquez
Adriana
A
Saucedo-Villarreal
Nubia
N
López-Alarcón
Mardia
M
Sánchez-Muñoz
Fausto
F
Domínguez-López
Aarón
A
Gutiérrez-Aguilar
Ruth
R
Menjivar
Marta
M
Coral-Vázquez
Ramón
R
Hernández-Stengele
Gabriel
G
Vital-Reyes
Victor S
VS
Acuña-Alonzo
Victor
V
Romero-Hidalgo
Sandra
S
Ruiz-Gómez
Doris G
DG
Riaño-Barros
Daniela
D
Herrera
Miguel F
MF
Gómez-Pérez
Francisco J
FJ
Froguel
Philippe
P
García-García
Eduardo
E
Teresa Tusié-Luna
M
M
Aguilar-Salinas
Carlos A
CA
Canizales-Quinteros
Samuel
S
D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000208:ethnology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D018570:Risk Assessment; D012307:Risk Factors; D050151:Subcutaneous Fat / Q000737:chemistry; D015854:Up-Regulation
D011506:Proteins; D012333:RNA, Messenger; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human