A study on microwave-induced melt granulation in a single pot high shear processor.
Microwave-induced high shear melt granulation was compared with conventional melt granulation performed in the same processor. Admixtures of lactose 200M and anhydrous dicalcium phosphate were granulated with polyethylene glycol 3350. Different heating mechanisms in the two processes necessitated the use of different parameters for process monitoring and control. Mixer power consumption was suitable for monitoring agglomerate growth under microwave-induced heating. Product temperature was a better indicator of agglomeration propensity in conventional melt granulation. These were attributed to the disparities in heat acquisition rates and heating uniformities of the powders as well as variation in baseline mixer power consumption between the two processes.
Liew
C V
CV
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.
Loh
Z H
ZH
Heng
P W S
PW
Lee
C C
CC
D002130:Calcium Phosphates / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D005079:Excipients / Q000737:chemistry*; D006358:Hot Temperature; D007785:Lactose / Q000737:chemistry; D008872:Microwaves; D011092:Polyethylene Glycols / Q000737:chemistry; D011208:Powders; D013678:Technology, Pharmaceutical / Q000379:methods*
D002130:Calcium Phosphates; D005079:Excipients; D011208:Powders; D011092:Polyethylene Glycols; D007785:Lactose; C485829:calcium phosphate, dibasic, anhydrous