title: Immunohistochemical expression of somatostatin type 2A receptor in neuroendocrine carcinoma of uterine cervix.
abstract: BACKGROUND
  Somatostatin and its analogues inhibit the growth of various kinds of endocrine and exocrine cells via the somatostatin receptor (SSTR). Expression of SSTR2A has been reported in many well-differentiated neuroendocrine tumors and small numbers of poorly differentiated neuroendocrine carcinomas. SSTR2A-positive neuroendocrine tumors may be treatable by SS analogues. Uterine cervical neuroendocrine carcinoma is generally associated with poor prognosis.
  
  
  METHODS
  We examined the expression of SSTR2A and other neuroendocrine markers [neural cell adhesion molecule (NCAM), chromogranin A, and synaptophysin] by immunohistochemical methods in seven neuroendocrine tumors of the uterine cervix: five small cell carcinomas and two large cell neuroendocrine carcinomas.
  
  
  RESULTS
  SSTR2A was expressed in one small cell carcinoma and two neuroendocrine large cell carcinomas. The cell membrane of cells in these carcinomas showed strong immunohistochemical reactivity for SSTR2A. SSTR2A-positive cases are also frequently positive for the expression of chromogranin A. Treatment with SSTR2A may be effective for endocrine tumors. The results indicate the usefulness of SSTR2A analogs for the treatment of some uterine neuroendocrine carcinomas.
authors: Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. h-kaji@is.icc.u-tokai.ac.jp
authors: Hiroshi
authors: H
authors: Kajiwara
authors: Kenichi
authors: K
authors: Hirabayashi
authors: Masaki
authors: M
authors: Miyazawa
authors: Naoya
authors: N
authors: Nakamura
authors: Takeshi
authors: T
authors: Hirasawa
authors: Toshinari
authors: T
authors: Muramatsu
authors: Mikio
authors: M
authors: Mikami
authors: Masanori
authors: M
authors: Yasuda
authors: R Y
authors: RY
authors: Osamura
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism*; D053379:Chromogranin A; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism; D017481:Receptors, Somatostatin / Q000096:biosynthesis*; D016708:Synaptophysin / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D053379:Chromogranin A; D019006:Neural Cell Adhesion Molecules; D017481:Receptors, Somatostatin; D016708:Synaptophysin; C093733:somatostatin receptor 2