title: The role of preoperative antibiotics in the prevention of wound infection after day case surgery for inguinal hernia in children in Ile Ife, Nigeria.
abstract: OBJECTIVE
  Day case surgery for inguinal hernia had been an established practice of the Paediatric Surgery Unit, OAUTHC, Ile Ife for about two decades. In a retrospective review of the practice from the same center, a high incidence of postoperative wound infection was noted, which was attributed to the poor personal hygiene of the patients. This prospective study, therefore, was performed to evaluate the role of a single dose of preoperative antibiotic (using gentamicin) in the prevention of these wound infections after day case surgery for inguinal hernia in children.
  
  
  METHODS
  This was a prospective study carried out over a period of 8 months from 11 April 2004 to 20 December 2004. During this period, 88 children aged from birth to 15 years were randomized into two groups of equal numbers to undergo elective inguinal herniotomy. The children in the test group received prophylactic intravenous gentamicin, 30 min before a groin crease incision was made, while those in the control group did not. All patients were subsequently followed up for 32 days for any evidence of a wound infection.
  
  
  RESULTS
  There were 104 wounds in the ratio of 50:54 in the control and test groups, respectively. All 54 wounds of the children who received prophylactic gentamicin healed primarily and without complication. Five cases of wound infections occurred in the control group, giving an infection rate of 4.8% (P < 0.041). Staphylococcus aureus was the single pathogen isolated from the infected postherniotomy wounds and this organism was wholly sensitive to gentamicin.
  
  
  CONCLUSIONS
  From the findings in this study, administration of preoperative gentamicin has a role in the prevention of wound infection after day case surgery for inguinal hernias in susceptible children. Preoperative intravenous gentamicin is therefore recommended as a prophylactic measure against wound infection after day case surgery for inguinal hernias in those children at risk of wound infection.
authors: Paediatric Surgery Unit, Department of Surgery, University of Calabar Teaching Hospital, Calabar, Nigeria. usangue@yahoo.co.uk
authors: U E
authors: UE
authors: Usang
authors: O A
authors: OA
authors: Sowande
authors: O
authors: O
authors: Adejuyigbe
authors: T I B
authors: TI
authors: Bakare
authors: O A
authors: OA
authors: Ademuyiwa
mesh_terms: D000293:Adolescent; D000556:Ambulatory Surgical Procedures; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D002648:Child; D002675:Child, Preschool; D005839:Gentamicins / Q000627:therapeutic use*; D006552:Hernia, Inguinal / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D009549:Nigeria / Q000453:epidemiology; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000453:epidemiology; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins