title: Diffuse reflectance spectroscopy with a self-calibrating fiber optic probe.
abstract: Calibration of the diffuse reflectance spectrum for instrument response and time-dependent fluctuation as well as interdevice variations is complicated, time consuming, and potentially inaccurate. We describe a novel fiber optic probe with a real-time self-calibration capability that can be used for tissue optical spectroscopy. The probe was tested in a number of liquid phantoms over a relevant range of tissue optical properties. Absorption and scattering coefficients are extracted with an average absolute error and standard deviation of 6.9%+/-7.2% and 3.5%+/-1.5%, respectively.
authors: Department of Biomedical Engineering, Duke University, Durham, NC 27705, USA. bing.yu@duke.edu
authors: Bing
authors: B
authors: Yu
authors: Henry
authors: H
authors: Fu
authors: Torre
authors: T
authors: Bydlon
authors: Janelle E
authors: JE
authors: Bender
authors: Nirmala
authors: N
authors: Ramanujam
mesh_terms: D002138:Calibration; D004867:Equipment Design; D005336:Fiber Optic Technology / Q000295:instrumentation* / Q000379:methods*; D009010:Monte Carlo Method; D055100:Optical Fibers; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D013057:Spectrum Analysis / Q000295:instrumentation* / Q000379:methods*; D014466:Ultraviolet Rays