Characterization of folate-graft-chitosan as a scaffold for nitric oxide release.
The preparation and characterization of nitric oxide (NO)-releasing chitosan-folate conjugates were reported. The secondary amine chitosan-folate conjugates exhibited a high storage capacity for NO (up to 84.3 nmol NO/mg) (when the graft rate of folate was 12.5%), greatly increasing the "payload" of released NO with the graft rate of folate increasing. The NO release durations (12h) observed for secondary amine the chitosan-folate conjugates with the high graft rate (12.5%) were largerly shorter compared to O2-protected diazeniumliolates with BrCH2CH3 (24 h), thus illustrating a macromolecular effect on NO release kinetics.
Wan
Ajun
A
School of Chemistry & Chemical Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China. wanajun@sjtu.edu.cn
Sun
Yan
Y
Li
Huili
H
D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry*; D006801:Humans; D009569:Nitric Oxide / Q000737:chemistry / Q000493:pharmacokinetics*; D020030:Nitric Oxide Donors / Q000138:chemical synthesis; D033561:Penaeidae / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D054457:Tissue Scaffolds / Q000737:chemistry*; D019737:Transplants
D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D048271:Chitosan; D005492:Folic Acid