[Peculiarities of leukotrienes metabolism in vitamin E deficiency in rats].
Some changes take place in the spectrum of fatty acid, cholesterol and individual phospholipids' composition in the rat liver, under E-hypovitaminosis, that can play a considerable role in the cell damage. The level of cysteinyl leucotriene decreases in the blood and liver under E-hypovitaminosis and it rises to the control level under vitamin E correction. This demonstrates the influence of tocopherol on 5-LO pathway arachidonic acid.
Silonov
S B
SB
Donchenko
H V
HV
Morozova
R P
RP
D000818:Animals; D015289:Leukotrienes / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D024505:Tocopherols / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome; D014811:Vitamin E Deficiency / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*
D015289:Leukotrienes; D024505:Tocopherols