Collagen type 3 alpha 1 polymorphism and risk of pelvic organ prolapse.
OBJECTIVE
To investigate whether pelvic organ prolapse (POP) is associated with collagen 3 alpha 1 (COL3A1) polymorphisms and other factors.


METHODS
A case-control association study was conducted with 84 women affected with POP and 147 controls. The genotypes of nucleotides COL3A1 rs1800255 and COL3A1 rs1801184 polymorphisms were ascertained by polymerase chain reaction and restriction fragment length polymorphism analysis.


RESULTS
The distribution of the COL3A1 rs1800255 genotypes was significantly different among affected women and controls. Older age and incidence of COL3A1 rs1800255 genotype AA were significantly associated with risk of POP.


CONCLUSIONS
There may be an association between COL3A1 genotype and risk of POP.
Chen
Huey-Yi
HY
Graduate Institute of Integrated Medicine, China Medical University Hospital, Taichung, Taiwan.
Chung
Ya-Wen
YW
Lin
Wei-Yong
WY
Wang
Jiunn-Chin
JC
Tsai
Fuu-Jen
FJ
Tsai
Chang-Hai
CH
D000328:Adult; D000367:Age Factors; D001483:Base Sequence; D016022:Case-Control Studies; D024061:Collagen Type III / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014596:Uterine Prolapse / Q000235:genetics* / Q000503:physiopathology
C439971:COL3A1 protein, human; D024061:Collagen Type III