[Synthesis and antitumor activities of triazacyclodecane and its platinum (II) complex].
To search for potential antitumor drugs with potent efficiency and low toxicity, a novel 1,4,7-triazacyclodecane and its platinum (II) complex were synthesized. These compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, MS spectra, thermoanalysis and conductivity measurement. Antitumor activity study indicated these compounds had strong antitumor activity in vitro to some extent. Inhibition of human liver tumor of CA was examined by antitumor rate and growth rate, complex C showed inhibition activity on transplanting-tumor growth of CA, 12 mg x kg(-1) was as potent as cisplatin, its ID50 was 853.6 mg x kg(-1).
Zhou
Shuang-Sheng
SS
School of Pharmacy, Anhui College of Traditional Chinese Medicine Hefei 230031, China. zshuangsheng@126.com
Zhang
Qun-Ying
QY
Qin
Kei
K
Lu
Chuan-Hua
CH
Xie
Fu-Xing
FX
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011897:Random Allocation
C543510:(1,4,7-triazacyclodecane)platinum(II); D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds