Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population.
BACKGROUND
Genetic factors, as well as a combination of environmental factors, contribute to the risk of prostate cancer (PC). Recently, genome-wide linkage studies found several independent single nucleotide polymorphisms (SNPs) that are strongly associated with PC on chromosome 8q24.


METHODS
We analyzed two of these SNPs, rs1447295 and rs6983267, to examine association with the risk of PC in Japanese men. These SNPs were examined by a mismatch PCR-RFLP method in 507 PC patients (286 aggressive and 221 non-aggressive) and in 511 non-PC patients (124 benign prostatic hyperplasia and 387 normal male controls) and the allele frequencies were then compared between groups.


RESULTS
The rs1447295 A allele was associated with susceptibility to PC (PC vs. non-PC: P = 0.041; OR, 1.28; 95%CI = 1.01-1.61), and was more significantly associated with disease in aggressive PC (aggressive PC vs. normal controls, P = 0.013; OR, 1.43; 95%CI = 1.08-1.90). The rs6983267 G allele did not show significant association with susceptibility to PC (PC vs. non-PC: P = 0.967; OR, 1.00; 95%CI = 0.83-1.21). However, it was associated with disease in non-aggressive PC (non-aggressive PC vs. normal controls: P = 0.0068; OR, 1.43; 95%CI = 1.10-1.85).


CONCLUSIONS
The two SNPs at 8q24 were associated with an increased risk of prostate cancer and contributed to tumor aggression in Japanese men.
Terada
Naoki
N
Department of Urology, Kyoto University, Graduate School of Medicine, Kyoto, Japan.
Tsuchiya
Norihiko
N
Ma
Zhiyong
Z
Shimizu
Yosuke
Y
Kobayashi
Takashi
T
Nakamura
Eijiro
E
Kamoto
Toshiyuki
T
Habuchi
Tomonori
T
Ogawa
Osamu
O
D044466:Asian People / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8; D018450:Disease Progression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011470:Prostatic Hyperplasia / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology