title: [Effect of pentosan polysulphate (SP-54) on the level of prion physiological form in rat tissues].
abstract: It is established that except for already known influence of pentosan polysulphate (SP-54) on the expression of pathological prion, this preparation has an inhibiting effect in respect of physiological prion. Moreover, the reduction of concentration of physiologycal prion is registered in the central and peripheral organs of the prion-replicating system. It was also shown that inhibition of the studied protein leads to the growth in copper and zinc concentration in the proper organs and tissues, but at the same time activity of Cu/Zn-dependent superoxide dismutase does not change.
authors: V V
authors: VV
authors: Vlizlo
authors: V V
authors: VV
authors: Stadnyk
authors: Kh Ia
authors: KhIa
authors: Maĭor
authors: M V
authors: MV
authors: Kinakh
authors: P I
authors: PI
authors: Verbytskyĭ
authors: M M
authors: MM
authors: Kozak
mesh_terms: D000818:Animals; D053938:DNA Fragmentation / Q000187:drug effects; D015151:Immunoblotting; D008297:Male; D009928:Organ Specificity; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology*; D018621:PrPC Proteins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D018621:PrPC Proteins; D010426:Pentosan Sulfuric Polyester; D013482:Superoxide Dismutase