Aggressive characteristics of myeloblasts expressing CD7 in myelodysplastic syndromes.
Clinical data suggest that CD7+ myeloblasts are linked with poor prognosis in myeloid malignancies including myelodysplastic syndromes (MDS). To explore the biology behind this, we compared cell characteristics between CD34+CD7+ and CD34+CD7- myeloblasts from an MDS cell line and fresh samples from MDS patients. Compared with CD34+CD7- myeloblasts, CD34+CD7+ myeloblasts showed greater proliferative capacity, more active cell cycling, and less apoptosis. In analyses of a cell line, CD34+CD7+ myeloblasts produced CD34+CD7- myeloblasts and showed lower expressions of interleukin-8 and chemokine (C-C motif) ligand 2 genes, suggesting immaturity of these cells. These findings might underlie the clinical aggressiveness in CD7+ MDS.
Satoh
Chikako
C
Division of Hematology, Department of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
Tamura
Hideto
H
Yamashita
Taishi
T
Tsuji
Takashi
T
Dan
Kazuo
K
Ogata
Kiyoyuki
K
D019011:Antigens, CD7; D017209:Apoptosis; D002453:Cell Cycle; D049109:Cell Proliferation; D019744:Chemokines, C / Q000032:analysis; D042381:Granulocyte Precursor Cells / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D016209:Interleukin-8 / Q000032:analysis; D009190:Myelodysplastic Syndromes / Q000473:pathology*; D014407:Tumor Cells, Cultured
D019011:Antigens, CD7; D019744:Chemokines, C; D016209:Interleukin-8; C490470:XCL2 protein, human