Hyperhomocysteinemia in ankylosing spondylitis: prevalence and association with clinical variables.
We evaluated the prevalence and characteristics associated with hyperhomocysteinemia in ankylosing spondylitis (AS). Ninety-seven patients with AS were compared with 97 controls. The assessment included clinical characteristics, disease activity (BASDAI), functioning (BASFI), history of drugs, and erythrocyte sedimentation rate (ESR). Total serum homocysteine (tHcy) was determined by fluorescence polarization immunoassay. A higher frequency of hyperhomocysteinemia (>15 micromol/L) was observed in AS (12 vs. 1%, P = 0.002). In the multivariate analysis the risk for hyperhomocysteinemia was increased in patients with higher score of HAQ-S (OR = 5.27, 95% CI: 1.29-21.44) and higher ESR (OR = 1.09, 95% CI: 1.02-1.18). No statistical associations was observed between hyperhomocysteinemia with other variables including methotrexate or sulfasalazine utilization. In conclusion, this study found a significant prevalence of hyperhomocysteinemia in Mexican patients with AS mainly associated to a worst functional impairment. Further follow-up studies are required to evaluate the risk of cardiovascular disease in these patients.
Gonzalez-Lopez
Laura
L
Department of Internal Medicine-Rheumatology, Hospital General Regional 110, Instituto Mexicano del Seguro Social (IMSS), Mexico.
Sanchez-Hernandez
Julia D
JD
Aguilar-Chavez
Erika A G
EA
Cota-Sanchez
Adolfo R
AR
Lopez-Olivo
Maria A
MA
Villa-Manzano
Alberto I
AI
Ortega-Flores
Ricardo
R
Espinoza-Magaña
Genadia L
GL
Rojo-Contreras
Wendoline
W
Cardona-Muñoz
Ernesto G
EG
Gamez-Nava
Jorge I
JI
D000328:Adult; D001799:Blood Sedimentation; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications* / Q000453:epidemiology*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000453:epidemiology; D055815:Young Adult