title: Cell swelling-induced peptide hormone secretion.
abstract: Cell volume changes induced in various ways (anisosmotic environment, hormones, oxidative stress, substrate uptake) are an integral part of a signal transduction network regulating cell function. Cell swelling has received increasing attention as a stimulus for a variety of intracellular phenomena. One of the most remarkable effects of cell swelling is its powerful effect in inducing exocytosis of material in intracellular secretory vesicles. Secretion of essentially all so-packaged hormones including those from hypothalamus (thyrotropin-releasing hormone, TRH; gonadotropin-releasing hormone, GnRH), pituitary (LH, FSH, ACTH, MSH, TSH, prolactin, beta endorphin), pancreas (insulin, somatostatin, glucagon), heart (atrial natriuretic hormone) and kidney (renin) are stimulated in a concentration-related manner by medium hyposmolarity or isosmolar medium containing permeant molecules such as ethanol or urea (reviewed in Ref. 21). Cell swelling-induced exocytosis is not restricted to endocrine cells and hormones; medium hyposmolarity also induces secretion of exocrine pancreatic enzymes and myeloperoxidase from human polymorphonuclear leukocytes.
authors: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava 83306, Slovakia. vladimir.strbak@savba.sk
authors: Vladimir
authors: V
authors: Strbák
authors: Julius
authors: J
authors: Benicky
authors: Susan E
authors: SE
authors: Greer
authors: Zuzana
authors: Z
authors: Bacova
authors: Miroslava
authors: M
authors: Najvirtova
authors: Monte A
authors: MA
authors: Greer
mesh_terms: D000818:Animals; D048429:Cell Size; D010121:Oxytocin / Q000378:metabolism; D036361:Peptide Hormones / Q000378:metabolism*; D010902:Pituitary Gland / Q000166:cytology / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism
chemical_list: D036361:Peptide Hormones; D010121:Oxytocin; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin