In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile.
Agar dilution antimicrobial susceptibility testing (CLSI, M11-A7, 2007) performed for 208 toxin-producing clinical isolates of Clostridium difficile resulted in OPT-80 MICs ranging from 0.06 to 1 microg/ml, with 90% of the isolates inhibited by a concentration of 0.5 microg/ml. The in vitro activity of OPT-80 was independent of the susceptibilities of isolates to nine other antimicrobial agents.
Karlowsky
James A
JA
Department of Clinical Microbiology, Health Sciences Centre, MS673C, 820 Sherbrook Street, Winnipeg, Manitoba, Canada. jkarlowsky@hsc.mb.ca
Laing
Nancy M
NM
Zhanel
George G
GG
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000096:biosynthesis; D016360:Clostridioides difficile / Q000187:drug effects* / Q000302:isolation & purification / Q000378:metabolism; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy / Q000382:microbiology; D006027:Glycosides / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D006027:Glycosides; C487655:OPT 80