Enteral nutrition in adult Crohn's disease: present status and perspectives.
Enteral nutrition has long been a therapeutic alternative often used in adult Crohn's disease patients to obtain remission or clinical response, especially in those not responding to conventional therapy such as corticosteroids. However, the increasing use of immunosuppressors (6-mercaptopurine and azathioprine, methotrexate, etc.), and the advent of biotherapies (especially anti-tumor necrosis factor-alpha (TNF-alpha) antibodies), decreased its use in adult Crohn's disease. Nevertheless, enteral nutrition remains of interest in patients presenting concomitant malnutrition (in particular in nonobstructed patients needing surgery), or in those intolerant or who failed to other therapeutics. In addition, recent studies provide data indicating its potential interest in maintenance therapy in selected patients groups. Finally, future research (in particular in the field of immuno- or pharmaconutrition) could lead to enteral formula's improvement, with better tolerance and acceptability, as well as increased efficacy.
Dupont
Benoît
B
Service d'Hépato-Gastro-Entérologie et Nutrition, Pôle Reins-Digestif-Nutrition, Centre Hospitalier Universitaire de Caen, Hôpital Côte de Nacre, Caen Cedex, France.
Dupont
Claire
C
Justum
Anne-Marie
AM
Piquet
Marie-Astrid
MA
Reimund
Jean-Marie
JM
D000328:Adult; D003424:Crohn Disease / Q000150:complications / Q000628:therapy*; D004750:Enteral Nutrition / Q000379:methods*; D005973:Glutamine / Q000008:administration & dosage; D006801:Humans; D008055:Lipids / Q000008:administration & dosage; D053781:Transforming Growth Factor beta2 / Q000008:administration & dosage
D008055:Lipids; D053781:Transforming Growth Factor beta2; D005973:Glutamine