Changes in regulation of cell-cell adhesion during tumor transformation.
Cadherin-mediated cell-cell adhesion defines the integrity of most tissues. Cell-cell adherens junctions are dynamic structures whose functional state is regulated by interactions of cadherin with beta-catenin, p120, and actin cytoskeleton structures. Small GTPases of the Rho family and GTPase Rap1 play the central role in the formation and maintenance of cell-cell adhesion. Aberrant activation of signaling pathways, transcriptional repression of the E-cadherin gene, ectopic expression of N-cadherin, and disturbances in regulation of adhesive and transcriptional functions of beta-catenin stimulate tumor progression.
Gloushankova
N A
NA
Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia. natglu@hotmail.com.
D022005:Adherens Junctions / Q000201:enzymology / Q000378:metabolism*; D015820:Cadherins / Q000502:physiology; D051177:Catenins; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D010750:Phosphoproteins / Q000502:physiology; D051176:beta Catenin / Q000378:metabolism; D020827:rap1 GTP-Binding Proteins / Q000502:physiology; D020741:rho GTP-Binding Proteins / Q000502:physiology; D000095002:Delta Catenin
D015820:Cadherins; D051177:Catenins; D015815:Cell Adhesion Molecules; D010750:Phosphoproteins; D051176:beta Catenin; D020827:rap1 GTP-Binding Proteins; D020741:rho GTP-Binding Proteins; D000095002:Delta Catenin