title: [Quantum pharmacology: state of scientific research].
abstract: In the article literature data and own investigations are summarized. Quantum pharmacology is defined as science which uses methods of theoretical chemistry and quantum mechanics as well as a computer modeling for studying drug molecular structure, mechanisms of drug interactions to understand primary pharmacological reactions. Main investigations in quantum pharmacology have been carried out in these arias: 1. Study of drug molecular structure. 2. Quantitative structure-activity relationship study (QSAR). 3. Investigations of mechanisms of drugs action. 4. Pharmacophores study. 5. De novo drug design. 6. Study of protein-ligand interactions for description of reactions between drugs and biomolecules of organism. 7. Investigations of primary mechanisms of drugs action. Study of quantum-pharmacological properties of captopril-inhibitor of angiotensineconverting enzyme showed that its molecule belongs to group of soft reagents, that's why this substance will interact with soft alkaline substances-amino acids, unsaturated and aromatic compounds. Quantum-pharmacological investigations will favour the discovery of new effective drugs for treatment of different diseases.
authors: I S
authors: IS
authors: Chekman
mesh_terms: D035843:Biomedical Research / Q000639:trends*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D010600:Pharmacology / Q000639:trends*; D021281:Quantitative Structure-Activity Relationship; D011789:Quantum Theory
chemical_list: D004364:Pharmaceutical Preparations