title: The implications of stochastic synthesis for the conjugation of functional groups to nanoparticles.
abstract: Stochastic synthesis of a ligand coupled to a nanoparticle results in a distribution of populations with different numbers of ligands per nanoparticle. This distribution was resolved and quantified using HPLC and is in excellent agreement with the ligand/nanoparticle average measured by 1H NMR, gel permeation chromatography (GPC), and potentiometric titration, and yet significantly more disperse than commonly held perceptions of monodispersity. Two statistical models were employed to confirm that the observed heterogeneity is consistent with theoretical expectations.
authors: Program in Macromolecular Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors: Douglas G
authors: DG
authors: Mullen
authors: Ankur M
authors: AM
authors: Desai
authors: Jack N
authors: JN
authors: Waddell
authors: Xue-Min
authors: XM
authors: Cheng
authors: Christopher V
authors: CV
authors: Kelly
authors: Daniel Q
authors: DQ
authors: McNerny
authors: István J
authors: IJ
authors: Majoros
authors: James R
authors: JR
authors: Baker
authors: Leonard M
authors: LM
authors: Sander
authors: Bradford G
authors: BG
authors: Orr
authors: Mark M
authors: MM
authors: Banaszak Holl
mesh_terms: D000107:Acetylation; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D050091:Dendrimers / Q000138:chemical synthesis*; D004563:Electrochemistry; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011073:Polyamines / Q000138:chemical synthesis*; D013269:Stochastic Processes
chemical_list: D050091:Dendrimers; D008024:Ligands; D011073:Polyamines