ANCA-negative glomerulonephritis associated with nonasthmatic Churg-Strauss syndrome.
BACKGROUND
A 36-year-old white male with a history of allergic rhinitis and sinusitis presented to the emergency room with abdominal pain and diarrhea. Physical examination revealed fever, hypoxemia and a maculopapular rash. Laboratory tests showed proteinuria, hematuria, leukocytosis, eosinophilia and an elevated erythrocyte sedimentation rate.


METHODS
Physical examination, urine and blood analysis and culture, chest radiography, chest and abdominal CT, esophagogastroduodenoscopy, skin and kidney biopsy, serology and renal ultrasound.


METHODS
Pauci-immune focal necrotizing glomerulonephritis with crescents and interstitial eosinophilia, consistent with Churg-Strauss syndrome.


RESULTS
The patient was treated with methylprednisolone 1 g/day intravenously for 3 days. He also received oral clotrimazole and combined oral sulfamethoxazole and trimethoprim for prophylaxis against candidiasis and pneumonia, respectively. He left the hospital against medical advice and was lost to follow-up.
Chemmalakuzhy
Asha J
AJ
Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75216-7167, USA.
Zhou
Xin J
XJ
Hedayati
S Susan
SS
D000328:Adult; D015267:Churg-Strauss Syndrome / Q000150:complications*; D003937:Diagnosis, Differential; D005923:Glomerulosclerosis, Focal Segmental / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D008297:Male