title: [Influence of different copper and zinc supply on their concentrations in blood serum, liver and hair of dairy cows].
abstract: In a feeding trial at the Institute of Animal Nutrition of the Federal Research Institute of Animal Health (FLI) over 12 weeks with 20 cows of the German Holstein Breed the influence of different copper and zinc contents in the ration on their concentration in blood serum, liver and hair was tested. All animals received a diet based on maize- and grass silage ad libitum. The animals were divided in two groups with 10 cows each; group A received a concentrate according to their milk yield with a copper and zinc content as recommended (GfE 2001), whereas group B was offered a concentrate with roughly the double amount of copper and zinc. At the beginning and at the end of the trial a sample of blood, pigmented hair and a liver bioptate was taken from all animals to evaluate the incorporation of copper and zinc in these tissues. In serum and pigmented hair the copper concentrations did not differ between the two groups [13.4 for Group A and 12.5 micromol/L for Group B in serum respectively 6.8 (Group A) and 7.4 mg/kg DM (Group B) in pigmented hair]. Only the copper concentration in the liver was influenced by the different feeding. The higher copper content for group B resulted in a significantly higher copper concentration in the liver (506 mg/kg DM compared to 383 mg/kg DM). The liver is the best indicator organ for a sufficient copper supply. An increase in the zinc content in the ration resulted neither in higher zinc concentrations in serum (15.1 in Group B in comparison to 13.4 micromol/L for Group A) nor in higher zinc concentrations in liver (140 for Group B and 112 mg/kg DM for Group A) and pigmented hair (130 in Group A and 123 mg/kg DM in Group B). There is a significant correlation between copper intake and copper concentration in the liver (r = 0.46), whereas the correlation between zinc intake and zinc concentration in the liver is only tendencially (r = 0.23). The three tested samples serum, liver and cow hair are not qualified to reflect exactly a sufficient zinc supply.
authors: Institut für Tierernährung, Friedrich-Loeffler-Institut (FLI) - Bundesforschungsinstitut für Tiergesundheit, Braunschweig. markus.spolders@fli.bund.de
authors: Markus
authors: M
authors: Spolders
authors: Haidong
authors: H
authors: Sun
authors: Martin
authors: M
authors: Wähner
authors: Manfred
authors: M
authors: Grün
authors: Jürgen
authors: J
authors: Rehage
authors: Gerhard
authors: G
authors: Flachowsky
mesh_terms: D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002417:Cattle; D003300:Copper / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005260:Female; D006197:Hair / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D011897:Random Allocation; D015032:Zinc / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism*
chemical_list: D003300:Copper; D015032:Zinc