Overexpression of thymic stromal lymphopoietin in allergic rhinitis.
CONCLUSIONS
Thymic stromal lymphopoietin (TSLP) played an important role in the pathogenesis of allergic rhinitis (AR) and can be regarded a potential therapeutic target for the management of AR.


OBJECTIVE
To evaluate the possible role of TSLP in the pathogenesis of AR.


METHODS
We enrolled 16 patients of AR to investigate the expression of TSLP in nasal mucosa and evaluate the link of TSLP and interleukin-4 (IL-4). Expression of TSLP was detected by immunohistochemical analysis and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), and concentrations of TSLP and IL-4 were measured by enzyme-linked immunosorbent assay (ELISA).


RESULTS
TSLP was detected in all samples and the mRNA and protein expression of TSLP is increased significantly in AR nasal mucosa compared with normal control (P<0.05). TSLP production is tightly correlated with IL-4 and severity of AR (P<0.05).
Mou
Zhonglin
Z
Department of Otolaryngology, Hainan Provincial People's Hospital, HaiKou, China.
Xia
Jiahong
J
Tan
Yenong
Y
Wang
Xiangdong
X
Zhang
Yuan
Y
Zhou
Bing
B
Li
Huabin
H
Han
Demin
D
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007150:Immunohistochemistry; D015847:Interleukin-4 / Q000378:metabolism; D009297:Nasal Mucosa / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*; D006255:Rhinitis, Allergic, Seasonal / Q000378:metabolism*; D012720:Severity of Illness Index; D000094632:Thymic Stromal Lymphopoietin
D016207:Cytokines; D012333:RNA, Messenger; D015847:Interleukin-4; D000094632:Thymic Stromal Lymphopoietin