title: Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release.
abstract: Investigation of the roots of Myrica nana afforded five new cyclic diarylheptanoids, myricananins A-E (1-5), two new artifacts of myricananins A and B (6-7), and four known compounds, 12-hydroxymyricanone (8), alnusonol (9), myricatomentogenin (10), and actinidione (11). The structures of these new compounds were established by detailed spectroscopic methods. The stereochemistry of compounds 1 and 2 were determined by single-crystal X-ray diffraction. In exception of compounds 2, 6 and 10, all the other compounds were examined for their inhibitory effects on nitric oxide production in lipopolysaccharides-activated macrophages. Compounds 1, 3, 7, 8 and 9 inhibited the release of nitric oxide with IC(50) values of 45.32, 63.51, 52.81, 30.19 and 46.18muM, respectively. Furthermore, compound 1 was found to inhibit the expression of inducible nitric oxide synthase.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming, Institute of Botany, Chinese Academy of Sciences, Lanhei Road 134, Kunming, 650204 Yunnan, People's Republic of China.
authors: Junfeng
authors: J
authors: Wang
authors: Shasha
authors: S
authors: Dong
authors: Yuehu
authors: Y
authors: Wang
authors: Qing
authors: Q
authors: Lu
authors: Huimin
authors: H
authors: Zhong
authors: Guanhua
authors: G
authors: Du
authors: Li
authors: L
authors: Zhang
authors: Yongxian
authors: Y
authors: Cheng
mesh_terms: D036381:Diarylheptanoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides; D008262:Macrophage Activation / Q000187:drug effects* / Q000502:physiology; D031641:Myrica / Q000737:chemistry*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors / Q000378:metabolism; D013057:Spectrum Analysis; D014961:X-Ray Diffraction
chemical_list: D036381:Diarylheptanoids; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II