A case report of propofol dependence in a physician.
Propofol is a widely used general anaesthetic with multisite mechanisms and especially ultrashort activation of certain central GABA-A receptors. Since its introduction into the market in the mid 1980s this is the seventh report on propofol dependence in the literature. The present case shows for the first time that craving for propofol can be quite intense and able to induce addictive behaviour.
Bonnet
Udo
U
Rhine Hospital of Essen, Department of Addictive Behaviour and Addiction Medicine, Essen, Germany. udo.bonnet@uni-due.de
Harkener
Jörg
J
Scherbaum
Norbert
N
D000328:Adult; D018686:Anesthetics, Intravenous / Q000009:adverse effects; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D009042:Motivation; D009293:Opioid-Related Disorders / Q000175:diagnosis* / Q000523:psychology / Q000534:rehabilitation; D010815:Physician Impairment / Q000523:psychology*; D015742:Propofol / Q000009:adverse effects; D012008:Recurrence; D016320:Substance Abuse Treatment Centers; D015819:Substance Abuse, Intravenous / Q000175:diagnosis* / Q000523:psychology / Q000534:rehabilitation; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000523:psychology
D018686:Anesthetics, Intravenous; D015742:Propofol