title: Effectiveness and morbidity associated with reirradiation in conservative salvage management of recurrent soft-tissue sarcoma.
abstract: OBJECTIVE
  The management of isolated local recurrence of soft-tissue sarcoma is therapeutically complex, and functional conservative management is preferable to radical or amputative salvage surgery. This study reviews the University of Florida experience using conservative resection and reirradiation to manage isolated local recurrences of soft-tissue sarcoma.
  
  
  METHODS
  Between 1976 and 2005, a total of 14 patients who underwent primary conservative resection and irradiation developed isolated local recurrence and were managed with salvage conservative resection and reirradiation. Of the patients treated, 3 had tumors of the distal extremity, 8 had tumors of the proximal extremity, and 3 had tumors of the trunk. At the time of recurrence, 64% of tumors were greater than 5 cm and 79% were high grade. In combination with gross total resection, 13 of 14 patients received external beam radiotherapy with or without brachytherapy, and 1 patient was treated with brachytherapy alone. Two patients received chemotherapy.
  
  
  RESULTS
  The median follow-up was 30 months, and no living patients were lost during follow-up. From retreatment, the 5-year actuarial overall survival, cause-specific survival, and local control rates were 40%, 40%, and 18% respectively. There was a 50% incidence of serious complication requiring either reoperation or leading to permanent functional impairment. Of the 14 patients, only 1 has remained disease free and without significant complications. No treatment factors, including achieving wide surgical margins or delivering higher radiation dosages, seemed to confer an advantage in local control.
  
  
  CONCLUSIONS
  Salvage therapy for management of locally recurrent soft-tissue sarcoma is challenging, and the effects of reoperation and reirradiation can be severe.
authors: Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA.
authors: Daniel J
authors: DJ
authors: Indelicato
authors: Kenyon
authors: K
authors: Meadows
authors: Charles P
authors: CP
authors: Gibbs
authors: Christopher G
authors: CG
authors: Morris
authors: Mark T
authors: MT
authors: Scarborough
authors: Robert A
authors: RA
authors: Zlotecki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000532:radiotherapy* / Q000601:surgery*; D013534:Survival; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult