title: Comparing folic acid pharmacokinetics among women of childbearing age: single dose ingestion of 1.1 versus 5 MG folic acid.
abstract: BACKGROUND
  A 2001 study suggested that supplementation with 5 mg folic acid, among women of childbearing age, is needed to render maximum protection against neural tube defects (NTD). No human study is presently available which examined the pharmacokinetics of 5 mg folic acid.
  
  
  OBJECTIVE
  To compare the pharmacokinetics of ingesting a single dose of 5 mg versus 1.1 mg folic acid contained in 2 prenatal multivitamins (PregVit and PregVit-Folic 5), and to estimate its contribution to steady-state folate levels.
  
  
  METHODS
  The pharmacokinetics of 1.1 mg folic acid was determined in a previously published study. The method was replicated among 6 healthy, non-pregnant women who were given 5 mg folic acid to ingest. Blood samples were drawn and serum folate concentrations were measured at various time points during 10 hours post-ingestion. Standard pharmacokinetic parameters were determined and compared with Student's t-test, when appropriate.
  
  
  RESULTS
  The mean area under the curve (AUC) of 1.1 mg and 5 mg folic acid were 147.6 +/- 52.8 (ng/mL) x hr and 997.5 +/- 271.9 (ng/mL) x hr, respectively (p<0.0002). An approximate 5-fold difference was detected in the peak concentrations (Cmax) between the 2 groups (p<0.0005), alongside a slight difference in the times to peak (Tmax) (p=0.02). The estimated steady-state serum folate concentrations produced by 1.1 mg and 5 mg folic acid were 6.2 +/- 2.2 ng/mL and 41.6 +/- 11.3 ng/mL, respectively (p<0.0002), prior to its summation with initial (baseline) steady-state levels.
  
  
  CONCLUSIONS
  Single dose administration between 1.1 mg and 5 mg folic acid demonstrated linear pharmacokinetics, with approximately a 5-fold difference between the 2 doses in serum folate contribution to steady-state levels, under ideal adherence.
authors: Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Canada.
authors: Patricia
authors: P
authors: Nguyen
authors: Rada
authors: R
authors: Boskovic
authors: Parvaneh
authors: P
authors: Yazdani
authors: Bhushan
authors: B
authors: Kapur
authors: Hilde
authors: H
authors: Vandenberghe
authors: Gideon
authors: G
authors: Koren
mesh_terms: D000328:Adult; D019540:Area Under Curve; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D014803:Vitamin B Complex; D005492:Folic Acid