Signaling by death receptors in the nervous system.
Cell death plays an important role both in shaping the developing nervous system and in neurological disease and traumatic injury. In spite of their name, death receptors can trigger either cell death or survival and growth. Recent studies implicate five death receptors--Fas/CD95, TNFR1 (tumor necrosis factor receptor-1), p75NTR (p75 neurotrophin receptor), DR4, and DR5 (death receptors-4 and -5)--in different aspects of neural development or degeneration. Their roles may be neuroprotective in models of Parkinson's disease, or pro-apoptotic in ALS and stroke. Such different outcomes probably reflect the diversity of transcriptional and posttranslational signaling pathways downstream of death receptors in neurons and glia.
Haase
Georg
G
Developmental Biology Institute of Marseille-Luminy, IBDML, CNRS UMR 6216, Marseille Cedex 09, France.
Pettmann
Brigitte
B
Raoul
Cédric
C
Henderson
Christopher E
CE
D000818:Animals; D009424:Nervous System Physiological Phenomena; D053218:Receptors, Death Domain / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D053218:Receptors, Death Domain