Neuron and gliocyte death induced by photodynamic treatment: signal processes and neuron-glial interactions.
The mechanisms of photodynamic (PD) damage to neurons and gliocytes are discussed. The spike reactions of neurons are described, with stimulation at high concentrations of photosensitizer and inhibition at low concentrations, accompanying necrosis. Glial cells developed both necrosis and apoptosis. Local laser inactivation of neurons increased light-induced apoptosis of gliocytes, i.e., neurons maintained gliocyte survival. Inter-and intracellular signaling plays an important role in the photolesioning of these cells. Studies using inhibitors and activators of signal proteins demonstrated the involvement of the Ca(2+)-dependent, adenylate cyclase, and tyrosine kinase pathways in the responses of neurons and gliocytes to PD treatment. Pharmacological modulation may alter the selectivity of PD neuron and gliocyte damage and the efficacy of PD treatment.
Uzdenskii
A B
AB
A. B. Kogan institute of Neurocybernetics, Southern Federal University, Rostov-on-Don, Russia. auzd@yandex.ru
Kolosov
M S
MS
Lobanov
A V
AV
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D002450:Cell Communication / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D016923:Cell Death / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D004553:Electric Conductivity; D006801:Humans; D008027:Light; D009457:Neuroglia / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D010778:Photochemotherapy / Q000009:adverse effects*; D017319:Photosensitizing Agents / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects
D017319:Photosensitizing Agents