Characterization of TolC efflux pump proteins from Pasteurella multocida.
Two TolC homologs, PM0527 and PM1980, were identified for Pasteurella multocida. A pm0527 mutant displayed increased susceptibility to a range of chemicals, including rifampin (512-fold) and acridine orange (128-fold). A pm1980 mutant showed increased susceptibility to rifampin, ceftazidime, and vancomycin.
Hatfaludi
Tamas
T
Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, VIC 3800, Australia.
Al-Hasani
Keith
K
Dunstone
Michelle
M
Boyce
John
J
Adler
Ben
B
D000595:Amino Acid Sequence; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D026901:Membrane Transport Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D016979:Pasteurella multocida / Q000187:drug effects / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D010802:Phylogeny
D001425:Bacterial Outer Membrane Proteins; D026901:Membrane Transport Proteins