title: A comparison of the effects of botulinum toxin A and steroid injection on nasal allergy.
abstract: OBJECTIVE
  To compare the effects of botulinum toxin A (BTX-A) with intranasal steroid injections on nasal symptoms in patients with allergic rhinitis (AR).
  
  
  METHODS
  A randomized, placebo-controlled, single-blinded clinical trial (patients were blinded).
  
  
  METHODS
  Thirty-nine patients were included in the study. AR was diagnosed by means of history, clinical examination, and skin prick test. Patients were randomly divided into three subgroups as follows: in group A, 25 units of BTX-A were injected into each inferior turbinate (total 50 units); in group B, 1 cc (20 mg/mL) of triamcinolone was injected into each inferior turbinate; and in group C, 1 cc of isotonic saline was injected as placebo. The symptoms of AR were scored by the patient on a six-point scale.
  
  
  RESULTS
  At all time points, group A was significantly better than group C. In the nasal obstruction and rhinorrhea scores, group A was significantly better than group B after 8 weeks.
  
  
  CONCLUSIONS
  BTX-A may provide better AR symptom relief in terms of duration and degree than a steroid injection.
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Inha University, College of Medicine, Jung-Gu, Incheon, Korea. mansatong2@naver.com
authors: Tae Yong
authors: TY
authors: Yang
authors: Yoon Gun
authors: YG
authors: Jung
authors: Young Hyo
authors: YH
authors: Kim
authors: Tae Young
authors: TY
authors: Jang
mesh_terms: D000293:Adolescent; D000328:Adult; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
chemical_list: D005938:Glucocorticoids; D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A; D014222:Triamcinolone Acetonide