title: Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.
abstract: Genome-wide association studies are discovering relationships between single-nucleotide polymorphisms and breast cancer, but the functions of these single-nucleotide polymorphisms are unknown and environmental exposures are likely to be important. We assessed whether breast cancer risk single-nucleotide polymorphisms interacted with ionizing radiation, a known breast carcinogen, among 859 cases and 1,083 controls nested in the U.S. Radiologic Technologists cohort. Among 11 Breast Cancer Association Consortium risk single-nucleotide polymorphisms, we found that the genotype-associated breast cancer risk varied significantly by radiation dose for rs2107425 in the H19 gene (P(interaction) = 0.001). H19 is a maternally expressed imprinted mRNA that is closely involved in regulating the IGF2 gene and could exert its influence by this or by some other radiation-related pathway.
authors: Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892-7238, USA. bhattip@mail.NIH.gov
authors: Parveen
authors: P
authors: Bhatti
authors: Michele M
authors: MM
authors: Doody
authors: Bruce H
authors: BH
authors: Alexander
authors: Jeff
authors: J
authors: Yuenger
authors: Steven L
authors: SL
authors: Simon
authors: Robert M
authors: RM
authors: Weinstock
authors: Marvin
authors: M
authors: Rosenstein
authors: Marilyn
authors: M
authors: Stovall
authors: Michael
authors: M
authors: Abend
authors: Dale L
authors: DL
authors: Preston
authors: Paul
authors: P
authors: Pharoah
authors: Jeffery P
authors: JP
authors: Struewing
authors: Alice J
authors: AJ
authors: Sigurdson
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics* / Q000401:mortality; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000235:genetics* / Q000401:mortality; D016273:Occupational Exposure / Q000009:adverse effects*; D020641:Polymorphism, Single Nucleotide; D011839:Radiation, Ionizing; D014481:United States