The discovery of pyrano[3,4-b]indole-based allosteric inhibitors of HCV NS5B polymerase with in vivo activity.
Laporte
Matthew G
MG
TetraLogic Pharmaceuticals, 343 Phoenixville Pike, Malvern, PA 19355, USA. mlaporte@tetralogicpharma.com
Jackson
Randy W
RW
Draper
Tandy L
TL
Gaboury
Janet A
JA
Galie
Kristin
K
Herbertz
Torsten
T
Hussey
Alison R
AR
Rippin
Susan R
SR
Benetatos
Christopher A
CA
Chunduru
Srinivas K
SK
Christensen
Joel S
JS
Coburn
Glen A
GA
Rizzo
Christopher J
CJ
Rhodes
Gerry
G
O'Connell
John
J
Howe
Anita Y M
AY
Mansour
Tarek S
TS
Collett
Marc S
MS
Pevear
Daniel C
DC
Young
Dorothy C
DC
Gao
Tiejun
T
Tyrrell
D Lorne J
DL
Kneteman
Norman M
NM
Burns
Christopher J
CJ
Condon
Stephen M
SM
D000494:Allosteric Regulation; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016174:Hepacivirus / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D051379:Mice; D016513:Mice, SCID; D008822:Mice, Transgenic; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012367:RNA, Viral / Q000097:blood / Q000302:isolation & purification; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000998:Antiviral Agents; D007211:Indoles; D011714:Pyrans; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase