Novel route of infection in experimental model of hydatid disease.
Viable protoscolices of Echinococcus granulosus injected into Swiss-albino mice by two different routes, viz. intraperitoneal and subcutaneous and in two different concentrations of 2000 and 1000 scolices, to observe the development of cysts have shown that subcutaneous route of infecting a mouse model is superior because of its low infecting dose and longer survival period of mouse. This finding should be helpful in experiments to observe the effect of drugs for the treatment of hydatidosis, in vivo, without the need of killing the mouse.
Kakru
Dalip K
DK
Department of Microbiology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India. dkkakru@yahoo.co.in
Sofi
Bashir A
BA
Assadullah
S
S
D000818:Animals; D004195:Disease Models, Animal; D004443:Echinococcosis / Q000469:parasitology*; D048209:Echinococcus granulosus / Q000472:pathogenicity*; D006801:Humans; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D051379:Mice; D016019:Survival Analysis; D013997:Time Factors