Proteomics joins the search for microRNA targets.
Two recent studies published in Nature (Baek et al. 2008; Selbach et al., 2008) analyze changes in the proteome in response to individual microRNAs (miRNAs). This approach is a powerful means to identify miRNA targets and to quantify the contribution of translational repression to posttranscriptional gene silencing by miRNAs.
Grosshans
Helge
H
Friedrich Miescher Institute for Biomedical Research, CH-4002 Basel, Switzerland. helge.grosshans@fmi.ch
Filipowicz
Witold
W
D000818:Animals; D019295:Computational Biology; D006367:HeLa Cells; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D011506:Proteins / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*
D035683:MicroRNAs; D011506:Proteins