[Effect of pentosan polysulphate (SP-54) on the level of prion physiological form in rat tissues].
It is established that except for already known influence of pentosan polysulphate (SP-54) on the expression of pathological prion, this preparation has an inhibiting effect in respect of physiological prion. Moreover, the reduction of concentration of physiologycal prion is registered in the central and peripheral organs of the prion-replicating system. It was also shown that inhibition of the studied protein leads to the growth in copper and zinc concentration in the proper organs and tissues, but at the same time activity of Cu/Zn-dependent superoxide dismutase does not change.
Vlizlo
V V
VV
Stadnyk
V V
VV
Maĭor
Kh Ia
KhIa
Kinakh
M V
MV
Verbytskyĭ
P I
PI
Kozak
M M
MM
D000818:Animals; D053938:DNA Fragmentation / Q000187:drug effects; D015151:Immunoblotting; D008297:Male; D009928:Organ Specificity; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology*; D018621:PrPC Proteins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
D018621:PrPC Proteins; D010426:Pentosan Sulfuric Polyester; D013482:Superoxide Dismutase