title: Repeated measurements of respiratory mechanics in developing rats utilizing a forced oscillation technique.
abstract: The ability to successfully intubate the trachea of rats repeatedly over time, recover them, and perform repeated measures of changes in respiratory mechanics is important. The authors performed experiments utilizing 2 groups of rats at various ages in their development. Rats in the single-measurement group were studied at 1 age only. Rats in the repeated-measurement group were studied at each age point over time. Measurements of respiratory mechanics were made utilizing a forced-oscillation technique. We found no differences in respiratory mechanics between the 2 groups. Our results demonstrate that developing rats can be studied longitudinally to illustrate maturational changes in respiratory mechanics.
authors: Section of Critical Care Medicine, Department of Pediatrics, Physiology and Biophysics, University of Arkansas for Medical Sciences College of Medicine, Little Rock, Arkansas, USA. heulittmarkj@uams.edu
authors: Mark J
authors: MJ
authors: Heulitt
authors: Stacie M
authors: SM
authors: Jones
authors: Shirley J
authors: SJ
authors: Holt
authors: Tracy L
authors: TL
authors: Thurman
authors: Chan-Hee
authors: CH
authors: Jo
authors: Pippa M
authors: PM
authors: Simpson
mesh_terms: D000367:Age Factors; D000375:Aging; D000818:Animals; D003198:Computer Simulation; D007442:Intubation, Intratracheal; D008168:Lung / Q000254:growth & development*; D008297:Male; D008954:Models, Biological; D009991:Oscillometry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics