title: SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.
abstract: We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 2 diabetes. We detected consistent association of a SNP in KCNQ1 (rs2283228) with the disease in several independent case-control studies (additive model P = 3.1 x 10(-12); OR = 1.26, 95% CI = 1.18-1.34). Several other SNPs in the same linkage disequilibrium (LD) block were strongly associated with type 2 diabetes (additive model: rs2237895, P = 7.3 x 10(-9); OR = 1.32, 95% CI = 1.20-1.45, rs2237897, P = 6.8 x 10(-13); OR = 1.41, 95% CI = 1.29-1.55). The association of these SNPs with type 2 diabetes was replicated in samples from Singaporean (additive model: rs2237895, P = 8.5 x 10(-3); OR = 1.14, rs2237897, P = 2.4 x 10(-4); OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 x 10(-11); OR = 1.24, rs2237897, P = 1.2 x 10(-4); OR = 1.36).
authors: Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa 230-0045, Japan.
authors: Hiroyuki
authors: H
authors: Unoki
authors: Atsushi
authors: A
authors: Takahashi
authors: Takahisa
authors: T
authors: Kawaguchi
authors: Kazuo
authors: K
authors: Hara
authors: Momoko
authors: M
authors: Horikoshi
authors: Gitte
authors: G
authors: Andersen
authors: Daniel P K
authors: DP
authors: Ng
authors: Johan
authors: J
authors: Holmkvist
authors: Knut
authors: K
authors: Borch-Johnsen
authors: Torben
authors: T
authors: Jørgensen
authors: Annelli
authors: A
authors: Sandbaek
authors: Torsten
authors: T
authors: Lauritzen
authors: Torben
authors: T
authors: Hansen
authors: Siti
authors: S
authors: Nurbaya
authors: Tatsuhiko
authors: T
authors: Tsunoda
authors: Michiaki
authors: M
authors: Kubo
authors: Tetsuya
authors: T
authors: Babazono
authors: Hiroshi
authors: H
authors: Hirose
authors: Matsuhiko
authors: M
authors: Hayashi
authors: Yasuhiko
authors: Y
authors: Iwamoto
authors: Atsunori
authors: A
authors: Kashiwagi
authors: Kohei
authors: K
authors: Kaku
authors: Ryuzo
authors: R
authors: Kawamori
authors: E Shyong
authors: ES
authors: Tai
authors: Oluf
authors: O
authors: Pedersen
authors: Naoyuki
authors: N
authors: Kamatani
authors: Takashi
authors: T
authors: Kadowaki
authors: Ryuichi
authors: R
authors: Kikkawa
authors: Yusuke
authors: Y
authors: Nakamura
authors: Shiro
authors: S
authors: Maeda
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D051657:KCNQ1 Potassium Channel / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012846:Singapore; D044465:White People / Q000235:genetics*
chemical_list: D051657:KCNQ1 Potassium Channel; C496909:KCNQ1 protein, human