title: Cefuroxime prophylaxis is effective in noninstrumented spine surgery: a double-blind, placebo-controlled study.
abstract: METHODS
  Double-blind, placebo-controlled randomized clinical trial.
  
  
  OBJECTIVE
  To assess the efficacy of 1 preoperative 1.5 g dose of cefuroxime in preventing surgical site infection after surgery for herniated disc.
  
  
  BACKGROUND
  Antibiotic prophylaxis was only tested in nonconclusive trials in this setting.
  
  
  METHODS
  The study was conducted in 2 university hospitals in Switzerland. Patients were assessed for occurrence of surgical site infection (defined by the criteria of the Centers for Diseases Control and Prevention), other infections, or adverse events up to 6 months after surgery. Outcome measures were compared in a univariate, per-protocol analysis.
  
  
  RESULTS
  Baseline characteristics were similar in patients allocated to cefuroxime (n = 613) or placebo (n = 624). Eight (1.3%) patients in the cefuroxime group and 18 patients (2.8%) in the placebo group developed a surgical site infection (P = 0.073). A diagnosis of spondylodiscitis or epidural abscess was made in 9 patients in the placebo group, but none in the cefuroxime group (P < 0.01), which corresponded to a number necessary to treat of 69 patients to prevent one of these infections. There were no significant adverse events attributed to either cefuroxime or placebo.
  
  
  CONCLUSIONS
  A single, preoperative dose of cefuroxime significantly reduces the risk of organ-space infection, most notably spondylodiscitis, after surgery for herniated disc.
authors: Service of Hospital Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
authors: Christiane
authors: C
authors: Petignat
authors: Patrick
authors: P
authors: Francioli
authors: Stephan
authors: S
authors: Harbarth
authors: Luca
authors: L
authors: Regli
authors: François
authors: F
authors: Porchet
authors: Alain
authors: A
authors: Reverdin
authors: Benedict
authors: B
authors: Rilliet
authors: Nicolas
authors: N
authors: de Tribolet
authors: André
authors: A
authors: Pannatier
authors: Didier
authors: D
authors: Pittet
authors: Giorgio
authors: G
authors: Zanetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019072:Antibiotic Prophylaxis / Q000379:methods*; D002444:Cefuroxime / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000188:drug therapy / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000379:methods*; D013530:Surgical Wound Infection / Q000517:prevention & control
chemical_list: D002444:Cefuroxime