title: Furan oligomers and beta-carbolines from terrestrial streptomycetes.
abstract: 2,5-Bis(hydroxymethyl)furan monoacetate (3) and 2,5-bis(hydroxymethyl)furan diacetate (4) were obtained as new natural products from an ethyl acetate extract of the terrestrial Streptomyces sp. isolate GW11/1695. Another Streptomyces isolate, GW21/1313, delivered a dimer (6) and a trimer (7) of (hydroxymethyl)furfural. The latter strain also produced 4-hydroxy-2-(5-(hydroxymethyl)furan-2-ylmethylene)-5-methylfuran-3-one (5), perlolyrin (8), and two new beta-carboline derivatives, 9 and 10. 2,5-Bis(hydroxymethyl)furan diacetate (4) exhibited weak cytotoxic activity against brine shrimp larvae.
authors: Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
authors: Serge
authors: S
authors: Fotso
authors: Rajendra P
authors: RP
authors: Maskey
authors: Dirk
authors: D
authors: Schröder
authors: Anna S
authors: AS
authors: Ferrer
authors: Iris
authors: I
authors: Grün-Wollny
authors: Hartmut
authors: H
authors: Laatsch
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D005663:Furans