title: Possible relationship between the risk of Japanese bladder cancer cases and the CYP4B1 genotype.
abstract: Cytochrome P450 4B1 (CYP4B1) is involved in the metabolism of several xenobiotics, such as 2-aminofluorene, 2-naphthylamine and benzidine. CYP4B1 allelic variants CYP4B1*1-*7 were recently identified. We thus hypothesized that CYP4B1 genotypes may modify bladder cancer risk. We examined the CYP4B1 genotypes in 169 bladder cancer cases and 190 hospital controls using a hybridization probe assay. Among the CYP4B1 genotypes observed, the most frequent genotypes in both the groups were CYP4B1*1/*1, *1/*2, *1/*3 and *2/*2. Logistic regression analysis revealed that the subjects carrying the CYP4B1*1/*2 or *2/*2 genotypes had a 1.75-fold increased risk of bladder cancer (95% CI=1.03-2.95, P = 0.038) compared with the subjects carrying the CYP4B1*1/*1 genotype. We demonstrated the first genetic study regarding the association of CYP4B1 with bladder cancer. Our results suggest that CYP4B1 genotypes might have an effect on the risk of bladder cancer.
authors: Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
authors: Takamitsu
authors: T
authors: Sasaki
authors: Miho
authors: M
authors: Horikawa
authors: Kazuhiko
authors: K
authors: Orikasa
authors: Makoto
authors: M
authors: Sato
authors: Yoichi
authors: Y
authors: Arai
authors: Yoshitaka
authors: Y
authors: Mitachi
authors: Michinao
authors: M
authors: Mizugaki
authors: Masaaki
authors: M
authors: Ishikawa
authors: Masahiro
authors: M
authors: Hiratsuka
mesh_terms: D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D011110:Polymorphism, Genetic; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; C095029:cytochrome P-450 CYP4B1