[Age peculiarities in changes of free radical oxidation processes in the brain of rats with hypothyroidism].
The objective of the present experiment was to study age peculiarities of free radical protein oxidation and lipid peroxidation in brain of 1.5-month-old and 12-month-old rats with drug-induced hypothyroidism. It has been shown that hypothyroidism in both 1.5-month and 12-month old rat is accompanied by the oxidative stress in the brain. It manifests by an increase of content of lipid peroxidation products and protein carbonyls in mitochondrial and microsomal fractions. Hypothyroidism decreases the prooxidant effect of exercises on the brain mitochondria.
Ali
Khaddad Aĭkham
KA
Davydov
V V
VV
D000375:Aging / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D004195:Disease Models, Animal; D005609:Free Radicals / Q000378:metabolism*; D007037:Hypothyroidism / Q000097:blood / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D008861:Microsomes / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D050050:Protein Carbonylation; D051381:Rats; D017208:Rats, Wistar; D013963:Thyroid Hormones / Q000097:blood / Q000378:metabolism
D005609:Free Radicals; D013963:Thyroid Hormones; D002374:Catalase