title: Aldose reductase inhibitors from Viola hondoensis W. Becker et H Boss.
abstract: The isolation and characterization of rat lens aldose reductase inhibitors from the Viola hondoensis W. Becker et H Boss were conducted. The extracts and organic fractions from V. hondoensis were tested. The MeOH extract and EtOAc fraction were found to exhibit potent rat lens aldose reductase inhibition in vitro, their IC(50) being 1.2 and 0.6 microg/ml, respectively. One major isoflavonoid glycoside was isolated from the ethyl acetate soluble fraction of V. hondoensis. Kakkalide was found to be the potential rat lens aldose reductase inhibitor (IC(50) = 0.34 microg/ml), and may be useful for the prevention and/or treatment of diabetic complications.
authors: Department of Applied Life Science, Kon Kuk University, Seoul, 143-701, South Korea.
authors: Ill-Min
authors: IM
authors: Chung
authors: Min-Young
authors: MY
authors: Kim
authors: Won-Hwan
authors: WH
authors: Park
authors: Hyung-In
authors: HI
authors: Moon
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D007529:Isoflavones / Q000737:chemistry / Q000494:pharmacology; D007908:Lens, Crystalline / Q000187:drug effects / Q000201:enzymology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D032413:Viola / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D006027:Glycosides; D007529:Isoflavones; D010936:Plant Extracts; C108698:kakkalide; D000449:Aldehyde Reductase