title: Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population.
abstract: BACKGROUND
  Genetic factors, as well as a combination of environmental factors, contribute to the risk of prostate cancer (PC). Recently, genome-wide linkage studies found several independent single nucleotide polymorphisms (SNPs) that are strongly associated with PC on chromosome 8q24.
  
  
  METHODS
  We analyzed two of these SNPs, rs1447295 and rs6983267, to examine association with the risk of PC in Japanese men. These SNPs were examined by a mismatch PCR-RFLP method in 507 PC patients (286 aggressive and 221 non-aggressive) and in 511 non-PC patients (124 benign prostatic hyperplasia and 387 normal male controls) and the allele frequencies were then compared between groups.
  
  
  RESULTS
  The rs1447295 A allele was associated with susceptibility to PC (PC vs. non-PC: P = 0.041; OR, 1.28; 95%CI = 1.01-1.61), and was more significantly associated with disease in aggressive PC (aggressive PC vs. normal controls, P = 0.013; OR, 1.43; 95%CI = 1.08-1.90). The rs6983267 G allele did not show significant association with susceptibility to PC (PC vs. non-PC: P = 0.967; OR, 1.00; 95%CI = 0.83-1.21). However, it was associated with disease in non-aggressive PC (non-aggressive PC vs. normal controls: P = 0.0068; OR, 1.43; 95%CI = 1.10-1.85).
  
  
  CONCLUSIONS
  The two SNPs at 8q24 were associated with an increased risk of prostate cancer and contributed to tumor aggression in Japanese men.
authors: Department of Urology, Kyoto University, Graduate School of Medicine, Kyoto, Japan.
authors: Naoki
authors: N
authors: Terada
authors: Norihiko
authors: N
authors: Tsuchiya
authors: Zhiyong
authors: Z
authors: Ma
authors: Yosuke
authors: Y
authors: Shimizu
authors: Takashi
authors: T
authors: Kobayashi
authors: Eijiro
authors: E
authors: Nakamura
authors: Toshiyuki
authors: T
authors: Kamoto
authors: Tomonori
authors: T
authors: Habuchi
authors: Osamu
authors: O
authors: Ogawa
mesh_terms: D044466:Asian People / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8; D018450:Disease Progression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011470:Prostatic Hyperplasia / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology