[The evidence of matrix metalloproteinases and its tissue inhibitors in children's affected gingiva].
Matrix metalloproteinases (MMP) and its tissue inhibitors (TIMP) were studied in 14 affected and 11 "control" samples from children in cases of dental extraction. Cytokeratin 14 coexpression also was analyzed in this materials by immunohistochemical study. Total RNA was extracted and the transcript levels for MMP-19 and TIMP-4 were determined by semi-quantitative real-time reverse transcription-polymerase Chain reaction (RT-PCR). The results demonstrated direct correlation between increased MMP/TIMP ration and inflamed gingival tissue breakdown.
Gogiashvili
L E
LE
Kipiani
G E
GE
Khimshiashvili
N B
NB
Tsagareli
Z G
ZG
D002648:Child; D005881:Gingiva / Q000378:metabolism*; D006801:Humans; D053504:Matrix Metalloproteinases, Membrane-Associated / Q000378:metabolism*; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism*
D019714:Tissue Inhibitor of Metalloproteinases; D053504:Matrix Metalloproteinases, Membrane-Associated