title: Mechanisms of vestibulo-ocular reflex (VOR) cancellation in spinocerebellar ataxia type 3 (SCA-3) and episodic ataxia type 2 (EA-2).
abstract: The vestibulo-ocular reflex (VOR) mechanism triggers eye movements as a result of head motion in order to keep gaze stationary relative to the world. However, in order to shift the direction of the gaze along with head motion, the VOR mechanism must be overridden ("cancelled"). Two mechanisms have been proposed to explain this cancellation: a reduction of the VOR gain or activation of smooth pursuit (SP) eye movements in the opposite direction. We studied VOR cancellation using the magnetic search coil in six spinocerebellar ataxia type 3 (SCA-3) and four episodic ataxia type 2 (EA-2) patients, conditions that are known to have degraded SP but different degrees of VOR impairment. Abnormal VOR was found in two of the four EA-2 patients and all of the SCA-3 patients. All subjects possessed residual VOR, although when tested using head thrusts it was almost negligible in the SCA-3 patients. The EA-2 patients showed essentially no SP and the SCA-3 patients had poor SP. However, for all patients, the gain during VOR cancellation was comparable to normals. These results provide additional evidence that SP cancellation of the VOR cannot be the sole mechanism utilized in overriding the VOR in these patients.
authors: Department of Neurology, Meir Medical Center, Kfar Saba, Israel. cgordon@post.tau.ac.il
authors: Carlos R
authors: CR
authors: Gordon
authors: Avi
authors: A
authors: Caspi
authors: Ronen
authors: R
authors: Levite
authors: Ari Z
authors: AZ
authors: Zivotofsky
mesh_terms: D000818:Animals; D001259:Ataxia / Q000503:physiopathology*; D006801:Humans; D017827:Machado-Joseph Disease / Q000503:physiopathology*; D008297:Male; D011698:Pursuit, Smooth / Q000502:physiology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*