title: Clinical outcomes and therapeutic strategy in patients with acute myocardial infarction according to renal function: data from the Korean Acute Myocardial Infarction Registry.
abstract: BACKGROUND
  The aim of the present study was to evaluate the relationship between clinical outcomes after acute myocardial infarction (MI) and renal function by glomerular filtration rate (GFR) in patients with normal or mildly elevated serum creatinine concentrations.
  
  
  RESULTS
  As part of the Korean Acute Myocardial Infarction Registry (KAMIR), 6,834 acute MI patients with a serum creatinine concentration of <or=2.0 mg/dl were enrolled from November 2005 to December 2006. The renal function was stratified arbitrary to 5 groups: (1) normal function, >90.0; (2) preserved function, 75.0-89.9; (3) mild dysfunction, 60.0-74.9; (4) moderate dysfunction, 45.0-59.9; (5) severe dysfunction, <45 ml.min(-1). 1.73 m(-2). Clinical characteristics, mortality and adverse events were analyzed among each group. Although reperfusion and medical therapies were underused, the rates of mortality and adverse events were increased with declining renal function. After adjustment with confounders, severe and moderate renal dysfunctions were important risk predictors of in-hospital mortality, long-term mortality and adverse events.
  
  
  CONCLUSIONS
  The spectrum of renal function, when it was presented by GFR, is broad and is an important risk predictor for adverse outcomes after acute MI, even in patients with normal or mildly elevated serum creatinine concentrations. Furthermore, standard treatments were underused in any degree of renal dysfunction.
authors: Division of Cardiology, Yeungnam University Hospital, Daegu, Republic of Korea.
authors: Sang-Hee
authors: SH
authors: Lee
authors: Young-Jo
authors: YJ
authors: Kim
authors: Woong
authors: W
authors: Kim
authors: Jong-Seon
authors: JS
authors: Park
authors: Dong-Gu
authors: DG
authors: Shin
authors: Seung-Ho
authors: SH
authors: Hur
authors: Chong-Jin
authors: CJ
authors: Kim
authors: Myeong-Chan
authors: MC
authors: Cho
authors: Shung-Chull
authors: SC
authors: Chae
authors: Myung-Ho
authors: MH
authors: Jeong
authors: Taek-Jong
authors: TJ
authors: Hong
authors: Doo-Il
authors: DI
authors: Kim
authors: Kee-Sik
authors: KS
authors: Kim
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D007674:Kidney Diseases / Q000097:blood / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D012042:Registries
chemical_list: D003404:Creatinine