Multiple effects of HMG-CoA reductase inhibitors (statins) besides their lipid-lowering function.
The paper by Sharyo et al. shows that statins reduce the severity in a model of renal-ischemia reperfusion injury and raises the therapeutic possibility of using statins as pharmacological intervention against acute kidney injury. This, together with previous studies, indicates that statins exert a wide spectrum of anti-inflammatory, immunomodulatory, and protective effects besides their lipid-lowering function.
Haslinger-Löffler
Bettina
B
Institute of Medical Microbiology, University Hospital of Münster, Münster, Germany. bettina.loeffler@web.de
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology; D007249:Inflammation / Q000517:prevention & control; D015850:Interleukin-6 / Q000097:blood; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000293:injuries* / Q000503:physiopathology; D051379:Mice; D017035:Pravastatin / Q000494:pharmacology; D015427:Reperfusion Injury / Q000517:prevention & control*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D015850:Interleukin-6; D002784:Cholesterol; D017035:Pravastatin