Nitric oxide signaling and the regulation of myocardial function.
Nitric oxide, which is produced endogenously within cardiac myocytes by three distinct isoforms of nitric oxide synthase, is a key regulator of myocardial function. This review will focus on the regulation of myocardial function by each nitric oxide synthase isoform during health and disease, with a specific emphasis on the proposed end-targets and signaling pathways.
Ziolo
Mark T
MT
Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA. ziolo.1@osu.edu
Kohr
Mark J
MJ
Wang
Honglan
H
D000818:Animals; D002135:Calcium-Binding Proteins / Q000737:chemistry; D006152:Cyclic GMP / Q000378:metabolism; D006321:Heart / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000737:chemistry*; D052248:Nitric Oxide Synthase Type I / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D020033:Protein Isoforms; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism; D015398:Signal Transduction; D000099211:Phospholamban
D002135:Calcium-Binding Proteins; D006152:Cyclic GMP; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; D020033:Protein Isoforms; D019837:Ryanodine Receptor Calcium Release Channel; D000099211:Phospholamban; C496320:NOS1 protein, human; C496319:NOS2 protein, human