[Level of circulating interleukin-16 during preclinical stage of type I diabetes mellitus development in children].
The content of IL16 in blood serum of children with type I diabetes mellitus and healthy normoglycemic children with genetic burden of diabetes mellitus and positive to autoantibodies against the islets of Langerhans (GADA and IAA) was determined by the immunoenzyme method ELISA. Healthy normoglycemic children with genetic burden but negative to GADA and IAA and healthy normoglycemic children without genetic burden but negative to GADA and IAA have been observed. The conducted examinations established that a statistically significant increase in the content of IL-16 and its decrease in developed diabetes mellitus patients have been noted to have place among children with genetic burden to diabetes, positive to GADA and IAA in comparison with control groups.
Popova
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D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000235:genetics / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D019410:Interleukin-16 / Q000097:blood*; D008297:Male; D010375:Pedigree
D001323:Autoantibodies; D019410:Interleukin-16