title: A color Doppler ultrasound-based comparative study between stavudine and non-stavudine regimens in the onset of vascular lesions in HIV-1-positive patients.
abstract: BACKGROUND
  The present study aimed to investigate the role of stavudine in the onset of premature vascular lesions using an ultrasound color Doppler evaluation of the carotid vessels.
  
  
  METHODS
  A total of 266 patients were evaluated: 149 were treated with stavudine (group I) and 117 without stavudine (group II).
  
  
  RESULTS
  Of the patients in group I, 41% exhibited vascular lesions vs. 26% in group II (p=0.0103). The two groups were further divided into subgroups Ia (stavudine and proteinase inhibitor, PI), Ib (stavudine and non-nucleotidic reverse transcriptase inhibitor, NNRTI), IIa (PI, without stavudine) and IIb (NNRTI without stavudine). A higher prevalence of lesions emerged in group Ia, while group IIa were at higher risk of developing vascular lesions than groups Ib and IIb.
  
  
  CONCLUSIONS
  Although stavudine per se does not seem to determine damage of the epiaortic vessels, the association of a PI with stavudine is related to a significantly higher rate of lesions.
authors: Clinica delle Malattie Infettive, Università di Bari, Italy. p_maggi@yahoo.com
authors: Paolo
authors: P
authors: Maggi
authors: Antonio
authors: A
authors: Chirianni
authors: Antonio
authors: A
authors: Lillo
authors: Francesco
authors: F
authors: Perilli
authors: Miriam
authors: M
authors: Gargiulo
authors: Vincenzo
authors: V
authors: Esposito
authors: Chiara
authors: C
authors: Bellacosa
authors: Giuseppe
authors: G
authors: Pastore
authors: Guido
authors: G
authors: Regina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006679:HIV Seropositivity; D006801:Humans; D008297:Male; D008875:Middle Aged; D018119:Stavudine / Q000627:therapeutic use*; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler / Q000379:methods*; D014652:Vascular Diseases / Q000150:complications* / Q000000981:diagnostic imaging* / Q000188:drug therapy*
chemical_list: D019380:Anti-HIV Agents; D018119:Stavudine