[Synthesis, characterization and antimicrobial activity of konjac glucomannan derivative with quaternary ammonium salts].
Methacryloxylethyl tetradecyl dimethyl ammonium bromide was grafted onto konjac glucomannan using ceric ammonium nitrate as an initiator, and the konjac glucomannan derivative with quaternary ammonium salts was obtained. The konjac glucomannan derivative was investigated by hydrogen nuclear magnetic resonance spectroscopy (1H NMR), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), and Zeta sizer nano series. The antimicrobial properties of the konjac glucomannan derivative against selected microorganisms were tested by the quantitative suspension method. The results revealed that (1) methacryloxylethyl tetradecyl dimethyl ammonium bromide can be grafted onto the surface of the konjac glucomannan, and the percentage grafting increases with increasing the amount of methacryloxylethyl tetradecyl dimethyl ammonium bromide. (2) The Zeta potential showed that the isoelectric point of the konjac glucomannan and the modified konjac glucomannan is pH 4. 5 and pH 9. 9, respectively. The shift of the isoelectric point is due to the quaternary ammonium groups. (3) The obtained konjac glucomannan derivative has significant inhibition effect on the growth of microorganisms, and the bactericidal rates in 15 min for E. coil (8099), S. aureus (ATCC 6538) and C. albicans (ATCC10231) were 99.99%, 99.99% and 98.13%, respectively.
Lei
Wan-Xue
WX
The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, China. lwxscu@163.com
Xu
Xia
X
Lin
Fang
F
Yang
Qin-Huan
QH
Li
Zhen-Jun
ZJ
Zhang
Ting-You
TY
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning; D004355:Drug Stability; D009682:Magnetic Resonance Spectroscopy; D008351:Mannans / Q000138:chemical synthesis*
D000890:Anti-Infective Agents; D008351:Mannans; C022901:(1-6)-alpha-glucomannan