Roles of the Werner syndrome RecQ helicase in DNA replication.
Congenital deficiency in the WRN protein, a member of the human RecQ helicase family, gives rise to Werner syndrome, a genetic instability and cancer predisposition disorder with features of premature aging. Cellular roles of WRN are not fully elucidated. WRN has been implicated in telomere maintenance, homologous recombination, DNA repair, and other processes. Here I review the available data that directly address the role of WRN in preserving DNA integrity during replication and propose that WRN can function in coordinating replication fork progression with replication stress-induced fork remodeling. I further discuss this role of WRN within the contexts of damage tolerance group of regulatory pathways, and redundancy and cooperation with other RecQ helicases.
Sidorova
Julia M
JM
Department of Pathology, University of Washington, Seattle, WA 98195-7705, USA. julias@u.washington.edu
D000375:Aging; D000818:Animals; D002453:Cell Cycle; D004260:DNA Repair; D004261:DNA Replication; D005090:Exodeoxyribonucleases / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D008957:Models, Genetic; D053484:RecQ Helicases / Q000737:chemistry / Q000502:physiology*; D016196:S Phase; D016615:Telomere / Q000648:ultrastructure; D014898:Werner Syndrome / Q000235:genetics; D000071657:Werner Syndrome Helicase
D005090:Exodeoxyribonucleases; D053484:RecQ Helicases; C098785:WRN protein, human; D000071657:Werner Syndrome Helicase