title: Transhiatal esophagectomy in a high volume institution.
abstract: BACKGROUND
  The optimal operative approach for carcinoma at the lower esophagus and esophagogastric junction remains controversial. The aim of this study was to assess a single unit experience of transhiatal esophagectomy in an era when the use of systemic oncological therapies has increased dramatically.
  
  
  METHODS
  Between January 2000 and November 2006, 215 consecutive patients (182 males, 33 females, median age = 65 years) underwent transhiatal esophagectomy; invasive malignancy was detected preoperatively in 188 patients. 90 patients (42%) received neoadjuvant chemotherapy. Prospective data was obtained for these patients and cross-referenced with cancer registry survival data.
  
  
  RESULTS
  There were 2 in-hospital deaths (0.9%). Major complications included: respiratory complications in 65 patients (30%), cardiovascular complications in 31 patients (14%) and clinically apparent anastomotic leak in 12 patients (6%). Median length of hospital stay was 14 days. The radicality of resection was inversely related to T stage: an R0 resection was achieved in 98-100% of T0/1 tumors and only 14% of T4 tumors. With a median follow up of 26 months, one and five year survival rates were estimated at 81% and 48% respectively.
  
  
  CONCLUSIONS
  Transhiatal esophagectomy is an effective operative approach for tumors of the infracarinal esophagus and the esophagogastric junction. It is associated with low mortality and morbidity and a five survival rate of nearly 50% when combined with neoadjuvant chemotherapy.
authors: Department of general surgery, St Thomas' Hospital, Guy's and St Thomas', NHS foundation Trust, Lambeth Palace Road, London, UK. ardavies22@hotmail.com
authors: Andrew R
authors: AR
authors: Davies
authors: Matthew J
authors: MJ
authors: Forshaw
authors: Aadil A
authors: AA
authors: Khan
authors: Alia S
authors: AS
authors: Noorani
authors: Vanash M
authors: VM
authors: Patel
authors: Dirk C
authors: DC
authors: Strauss
authors: Robert C
authors: RC
authors: Mason
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000401:mortality / Q000601:surgery*; D016629:Esophagectomy / Q000379:methods* / Q000401:mortality / Q000706:statistics & numerical data*; D004943:Esophagogastric Junction; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D012042:Registries; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents