title: Targeting subcapsular antigens for prevention of Klebsiella pneumoniae infections.
abstract: Vaccination strategies against Klebsiella pneumoniae have largely focussed on the polysaccharide capsule. However, the large number and high prevalence of individual capsular serotypes limits the widespread applicability of capsule-based vaccines. This study establishes that immunization with purified LPS can protect mice against lethal challenge with K. pneumoniae, and that subcapsular antibodies directed against purified LPS can be used to treat and/or prevent experimental K. pneumoniae infection in mice. This approach offers potential for prophylaxis and/or therapy against drug-resistant strains of K. pneumoniae.
authors: Department of Microbiology & Immunology, The University of Melbourne, Parkville, Vic. 3010, Australia. abigailc@unimelb.edu.au
authors: Abigail
authors: A
authors: Clements
authors: Adam W
authors: AW
authors: Jenney
authors: Jacinta L
authors: JL
authors: Farn
authors: Lorena E
authors: LE
authors: Brown
authors: Georgia
authors: G
authors: Deliyannis
authors: Elizabeth L
authors: EL
authors: Hartland
authors: Martin J
authors: MJ
authors: Pearse
authors: Margaret B
authors: MB
authors: Maloney
authors: Steven L
authors: SL
authors: Wesselingh
authors: Odilia L
authors: OL
authors: Wijburg
authors: Richard A
authors: RA
authors: Strugnell
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000097:blood / Q000276:immunology / Q000627:therapeutic use*; D000942:Antigens, Bacterial / Q000276:immunology; D016667:Bacterial Capsules / Q000276:immunology*; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D007710:Klebsiella Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D007711:Klebsiella pneumoniae / Q000145:classification / Q000276:immunology*; D008070:Lipopolysaccharides / Q000008:administration & dosage* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D019081:O Antigens / Q000276:immunology; D012703:Serotyping; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D008070:Lipopolysaccharides; D019081:O Antigens