title: Primary malignant melanoma of the cervix: report of a case.
abstract: BACKGROUND
  To present a case of primary malignant melanoma of the cervix.
  
  
  METHODS
  The patient was admitted with the complaint of vaginal bleeding. Gynecological examination revealed a dark, papillary mass on the posterior lip of the cervix. Histopathology showed a malignant neoplasm with increased vascularity, indicating the possibility of a primary uterine cervical melanoma. Diagnosis of malignant melanoma was confirmed with immunohistochemistry, which showed diffuse positive reactions for S-100 protein and HBM-45, with no reaction for epithelial markers, namely cytokeratin AE1/AE3 and epithelial membrane antigen. An extensive search for a melanotic lesion in skin and in uveal tract was performed to verify the distinct site of melanoma. The tumor was stage IB1 according to the International Federation of Gynecology and Obstetrics classification.The patient underwent radical Wertheim-Meigs hysterectomy, bilateral salpingo-oopherectomy, and retroperitoneal pelvic lympadenectomy. Radiotherapy or chemotherapy was not performed in the postoperative period. She is now free of the disease 10 months after the operation.
  
  
  CONCLUSIONS
  Primary malignant melanoma of the cervix is a rare cervical malignancy.
authors: Department of Obstetrics and Gynecology, School of Medicine, Kocaeli University, Kocaeli, Turkey. gulserene@superonline.com
authors: Gülseren
authors: G
authors: Yücesoy
authors: Evrim
authors: E
authors: Kus
authors: Yigit
authors: Y
authors: Cakiroglu
authors: Bahar
authors: B
authors: Muezzinoglu
authors: Kursat
authors: K
authors: Yildiz
authors: Izzet
authors: I
authors: Yucesoy
mesh_terms: D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery