Role of spiramycin/cotrimoxazole association in the mother-to-child transmission of toxoplasmosis infection in pregnancy.
The purpose of this report is to evaluate the efficacy and safety of spiramycin/cotrimoxazole in the mother-to-child transmission of Toxoplasma gondii infection. We retrospectively analysed 76 infants born to mothers with toxoplasmosis during pregnancy and estimated the risk of mother-to-child transmission considering the gestational age at the time of infection. Seventy-six mothers were given spiramycin, cotrimoxazole and folinic acid; only two babies (2.6%) were infected by Toxoplasma and none of them showed signs or symptoms of congenital infection or interference of sulphamid on tetrahydrofolate reductase (THFR) either at birth or during follow-up. Treatment did not need to be stopped in any mother because of adverse drug effects. Our results seem to encourage the use of spiramycin/cotrimoxazole in women with toxoplasmosis during pregnancy.
Valentini
P
P
Department of Pediatrics, Pediatric Infectious Diseases Unit, Catholic University of the Sacred Heart, L.go A. Gemelli, 8, 00168 Rome, Italy. pvalentini@rm.unicatt.it
Annunziata
M L
ML
Angelone
D F
DF
Masini
L
L
De Santis
M
M
Testa
A
A
Grillo
R L
RL
Speziale
D
D
Ranno
O
O
D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D002955:Leucovorin / Q000009:adverse effects / Q000627:therapeutic use; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000517:prevention & control*; D012189:Retrospective Studies; D015572:Spiramycin / Q000009:adverse effects / Q000627:therapeutic use*; D014122:Toxoplasma / Q000187:drug effects; D014123:Toxoplasmosis / Q000188:drug therapy* / Q000635:transmission*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects / Q000627:therapeutic use*
D000890:Anti-Infective Agents; D015572:Spiramycin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002955:Leucovorin