title: Enhanced resistance of restraint-stressed mice to sepsis.
abstract: Sepsis remains a major health concern across the world. The effects of stress on host resistance to sepsis are still not very clear. To explore the effects of chronic stress on sepsis(') we examined the impact of restraint stress on the resistance of mice to sepsis. Interestingly, it was found that restraint stress enhanced the antisepsis resistance of mice and the concentrations of the proinflammatory cytokines IL-1, IL-6, IL-12, and TNF-alpha in the blood of stressed mice were dramatically reduced post Escherichia coli infection or LPS treatment as compared with that of controls (p < 0.05). In addition, the mRNA expressions of glucocorticoid-induced leucine zipper (GILZ) were up-regulated in the spleen and peritoneal macrophages of mice receiving restraint stress or dexamethasone treatment. These results demonstrate that restraint stress enhances the resistance of mice to sepsis, supporting corticotherapy for sepsis and proposing restraint-stressed mouse as an animal model to elucidate mechanisms of stress-associated, antisepsis resistance.
authors: College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.
authors: Yu
authors: Y
authors: Wang
authors: Ying
authors: Y
authors: Lu
authors: Duo
authors: D
authors: Yu
authors: Yongqiang
authors: Y
authors: Wang
authors: Fuyong
authors: F
authors: Chen
authors: Hanchun
authors: H
authors: Yang
authors: Shijun J
authors: SJ
authors: Zheng
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood; D004927:Escherichia coli Infections; D005786:Gene Expression Regulation; D007109:Immunity; D008070:Lipopolysaccharides / Q000494:pharmacology; D017737:Macrophages, Peritoneal; D051379:Mice; D012149:Restraint, Physical; D018805:Sepsis / Q000276:immunology*; D013154:Spleen; D013312:Stress, Physiological / Q000276:immunology*; D014157:Transcription Factors / Q000235:genetics
chemical_list: D016207:Cytokines; C498608:Dsip1 protein, mouse; D008070:Lipopolysaccharides; D014157:Transcription Factors