[Long-term results of treatment in patients with oligodendrogliomas and oligoastrocytomas of the cerebral hemispheres].
BACKGROUND
the current approach to treating patients with cerebral oligodendrogliomas and oligoastrocytomas involves surgical treatment with the maximum tumor resection in reasonable ranges, by taking into account the anatomic and physiological availability, followed by chemo- and radiotherapy. Nevertheless, it should be recognized that criteria for choosing the optimum regiment for the treatment of these tumors have not conclusively established.


METHODS
the long-term results of treatment were analyzed in 80 patients with oligoglial tumors (oligodendrogliomas and oligoastrocytomas in 31 and 49 patients, respectively) treated at the A.L. Polenov Russian Institute of Neurosurgery in 1990 to 2004. The patients' mean age was 18.9 years. 38.5% of tumors were located in the frontal lobe. In 67 (83.75%) patients, Karnoffsky score was 70-90. Radiotherapy was used in the treatment of 71 patients and postoperative chemotherapy in 52 (87,5%) patients.


RESULTS
After complex therapy, the mean survival was 80.6 months in patients with oligodendrogliomas, 63.3 months in those with anaplastic oligoastrocytomas, and 42 months in those with anaplastic oligodendrogliomas.
Iun'pén
Van
V
Oliushin
V E
VE
Ulitin
A Iu
AIu
Maslova
L N
LN
Petrov
A A
AA
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001254:Astrocytoma / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009837:Oligodendroglioma / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D011829:Radiation Dosage