Diabetes mellitus, body size and bladder cancer risk in a prospective study of Swedish men.
Epidemiologic studies on diabetes and body size in relation to risk of bladder cancer have yielded inconsistent results. We examined prospectively the associations between a history of diabetes, height, weight, body mass index and waist circumference, and the incidence of bladder cancer in the Cohort of Swedish Men, a prospective study of 45,906 men aged 45-79 years at baseline. During follow-up from 1998 through December 2007, 414 incident cases of bladder cancer were ascertained. A history of diabetes was not associated with risk of bladder cancer (multivariate rate ratio=1.16; 95% confidence interval=0.81-1.64). Similarly, no associations were observed for height, weight, body mass index or waist circumference. These findings in men do not support a role for diabetes, height or excess body mass in the aetiology of bladder cancer.
Larsson
Susanna C
SC
Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.se
Andersson
Swen-Olof
SO
Johansson
Jan-Erik
JE
Wolk
Alicja
A
D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D049628:Body Size / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology; D004812:Epidemiologic Methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D012959:Socioeconomic Factors; D013548:Sweden / Q000453:epidemiology; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000209:etiology*