Efficient ytterbium triflate catalyzed microwave-assisted synthesis of 3-acylacrylic acid building blocks.
The derivatives of 4-(hetero)aryl-4-oxobut-2-enoic acid are useful as building blocks in the synthesis of biologically active compounds. An efficient general protocol for the synthesis of these building blocks was developed. This method combines microwave assistance and ytterbium triflate catalyst and allows the fast preparation of the target acids starting from different (hetero)aromatic ketones and glyoxylic acid monohydrate giving pure products in 52-75% isolated yields.
Tolstoluzhsky
Nikita V
NV
Department of Organic Chemistry, V. N. Karazin Kharkiv National University, Svobody Square, 4, Kharkiv 61077, Ukraine.
Gorobets
Nikolay Yu
NY
Kolos
Nadezhda N
NN
Desenko
Sergey M
SM
D000179:Acrylates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D008698:Mesylates; D008872:Microwaves; D015018:Ytterbium
D000179:Acrylates; D008698:Mesylates; C012077:trifluoromethanesulfonic acid; D015018:Ytterbium