title: The relationship between early life stress and microstructural integrity of the corpus callosum in a non-clinical population.
abstract: BACKGROUND
  Previous studies have examined the impact of early life stress (ELS) on the gross morphometry of brain regions, including the corpus callosum. However, studies have not examined the relationship between ELS and the microstructural integrity of the brain.
  
  
  METHODS
  In the present study we evaluated this relationship in healthy non-clinical participants using diffusion tensor imaging (DTI) and self-reported history of ELS.
  
  
  RESULTS
  Regression analyses revealed significant reductions in fractional anisotropy (FA) within the genu of the corpus callosum among those exposed to the greatest number of early life stressors, suggesting reduced microstructural integrity associated with increased ELS. These effects were most pronounced in the genu of the corpus callosum compared to the body and splenium, and were evident for females rather than males despite no differences in total ELS exposure between the sexes. In addition, a further comparison of those participants who were exposed to no ELS vs. three or more ELS events revealed lower FA in the genu of the corpus callosum among the ELS-exposed group, with trends of FA reduction in the body and the whole corpus callosum. By contrast, there were no relationships between ELS and volumetric analysis of the CC regions. The two group did not differ significantly on measures of current depression, stress or anxiety.
  
  
  CONCLUSIONS
  Our results reveal that greater exposure to ELS is associated with microstructural alterations in the white matter in the absence of significant volumetric changes. Importantly, our results indicate that exposure to ELS is associated with abnormalities on DTI despite the absence of clinically significant psychiatric symptoms. Future studies are needed to determine whether specific types of ELS are more likely to impact brain structure and function.
authors: University of Missouri St. Louis, St. Louis, MO, USA.
authors: Robert
authors: R
authors: Paul
authors: Lorrie
authors: L
authors: Henry
authors: Stuart M
authors: SM
authors: Grieve
authors: Thomas J
authors: TJ
authors: Guilmette
authors: Raymond
authors: R
authors: Niaura
authors: Richard
authors: R
authors: Bryant
authors: Steven
authors: S
authors: Bruce
authors: Leanne M
authors: LM
authors: Williams
authors: Clark C
authors: CC
authors: Richard
authors: Ronald A
authors: RA
authors: Cohen
authors: Evian
authors: E
authors: Gordon