title: Effect of adeno-associated virus-mediated transfer of low density lipoprotein receptor gene on treatment of hypercholesterolemia.
abstract: Low density lipoprotein receptor (LDL-R) plays an important role in removing LDL from plasma and preventing prbducing atherosclerosis. To test hepatic reconstitution of LDLR expression is sufficient for metabolic correction of subjects with hypercholesterolemia; a recombinant adeno-associated virus (rAAV) carrying the human LDL receptor cDNA (AAV/LDL-R) was constructed. Using adenosome, a complex of ademviral capsid protein and lipsome, to transfer the rAAV into livers of rabbits with experimental hypercholesterolemia could elicit the production of LDL-R and lower plasma cholesterol level. These results demonstrate that AAV-mediated transfer of LDL-R gene may provide an alternative means to gene therapy of hypercholesterolemia.
authors: Institute of Cardiovascular Research, Beijing Medical University, 100083, Beijing, China.
authors: G
authors: G
authors: Chen
authors: L
authors: L
authors: Song
authors: X
authors: X
authors: Zhu
authors: X
authors: X
authors: Zhang
authors: C
authors: C
authors: Zhang
authors: T
authors: T
authors: Wang
authors: J
authors: J
authors: Tang