title: Some translations in vascular neurology. The Johann Jacob Wepfer Award 2008.
abstract: 'Translation' in medicine immediately suggests 'translational research', but there are many other varieties of 'translation'. I have selected 4 translations in the field of vascular neurology in which I have been involved in different respects: (1) the translation of results from men to women, taking the example of aspirin which, in primary prevention, decreases the risk of myocardial infarction in men and the risk of cerebral infarction in women, the reason for this sex difference being so far unknown; (2) the 'inverse translational research', from bedside to bench, taking the example of the disease we have identified--CADASIL--and showing how the study of one patient and his family led to the identification of a gene, Notch3, so far unknown in humans and to the discovery of its key role in the physiology of vascular smooth muscle cells; (3) the translation from individual case reports to multidisciplinary trials taking the example of hemicraniectomy in malignant cerebral infarction and emphasizing the interest in such rare and severe conditions of pooling and reporting the results of randomized clinical trials before the results of individual trials, and (4) the translation from research to practice, emphasizing not the well-known 'evidence to practice gap' but the slippery slope of 'lack of evidence to overpractice', taking the example of patent foramen ovale closure in migraine.
authors: Hôpital Lariboisière AP-HP, Université Paris Diderot, Paris, France. mg.bousser@lrb.aphp.fr
authors: Marie-Germaine
authors: MG
authors: Bousser
mesh_terms: D001241:Aspirin / Q000627:therapeutic use; D001363:Awards and Prizes; D035843:Biomedical Research / Q000639:trends; D046589:CADASIL / Q000235:genetics; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000235:genetics / Q000517:prevention & control / Q000628:therapy*; D002544:Cerebral Infarction / Q000517:prevention & control / Q000601:surgery; D003399:Craniotomy; D019317:Evidence-Based Medicine; D005260:Female; D054092:Foramen Ovale, Patent / Q000150:complications / Q000601:surgery; D006801:Humans; D008297:Male; D008499:Medical Records; D008881:Migraine Disorders / Q000209:etiology / Q000517:prevention & control; D009203:Myocardial Infarction / Q000517:prevention & control; D009462:Neurology / Q000639:trends; D016032:Randomized Controlled Trials as Topic; D000071656:Receptor, Notch3; D051880:Receptors, Notch / Q000235:genetics; D012737:Sex Factors; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents; C499374:NOTCH3 protein, human; D000071656:Receptor, Notch3; D051880:Receptors, Notch; D001241:Aspirin