The effect of gold nanorods on cell-mediated collagen remodeling.
Cardiac fibroblasts, the noncontractile cells of the heart, contribute to myocardial maintenance through the deposition, degradation, and organization of collagen. Adding polyelectrolyte-coated gold nanorods to three-dimensional constructs composed of collagen and cardiac fibroblasts reduced contraction and altered the expression of mRNAs encoding beta-actin, alpha-smooth muscle actin, and collagen type I. These data show that nanomaterials can modulate cell-mediated matrix remodeling and suggest that the targeted delivery of nanomaterials can be applied for antifibrotic therapies.
Sisco
Patrick N
PN
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, USA.
Wilson
Christopher G
CG
Mironova
Ekaterina
E
Baxter
Sarah C
SC
Murphy
Catherine J
CJ
Goldsmith
Edie C
EC
D000199:Actins / Q000737:chemistry; D000818:Animals; D002450:Cell Communication; D003094:Collagen / Q000737:chemistry*; D024042:Collagen Type I / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005347:Fibroblasts / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D009130:Muscle, Smooth / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry; D051381:Rats
D000199:Actins; D024042:Collagen Type I; D004337:Drug Carriers; D006046:Gold; D003094:Collagen