Cognitive memory control in borderline personality disorder patients.
BACKGROUND
It has been demonstrated that the mechanism of cognitive memory control in humans is sustained by the hippocampus and prefrontal cortices, which have been found to be structurally and functionally abnormal in borderline personality disorder (BPD). We investigated whether the memory control mechanism is affected in BPD.


METHODS
Nineteen Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV BPD patients and 19 matched healthy controls (HC) performed a specific think/no-think paradigm exploring the capacity of remembering and suppressing pair of words previously learned. After the think-no think phase, the second member of each word pair has to be remembered either when subjects are presented with the cue word showed at the beginning of the test (Same Probe Test; SPT) or when they are presented with an extra-list categorical word (Independent Probe Test; IPT). We evaluated the effect of suppression and of retrieval activity on later retention of words.


RESULTS
Both on the SPT and on the IPT, HC showed the expected improvement of memory retrieval on to-be-remembered words, unlike BPD patients. On the SPT, HC, but not BPD patients, correctly recalled significantly more words among remembered words (RW) than among suppressed words (SW). Similarly to HC, subjects with BPD without a history of childhood abuse showed a significantly higher percentage of correctly recalled words among RW than among SW.


CONCLUSIONS
The mechanism of active retrieval of memories and of improvement through repetition is impaired in BPD, particularly in those who experienced traumatic experiences. This impairment might play an important role, possibly resulting in the emergence of unwanted memories and dissociative symptoms.
Sala
M
M
Department of Physiological, Pharmacological and Cellular Sciences, University of Pavia, Pavia, Italy. michelasalacap@yahoo.it
Caverzasi
E
E
Marraffini
E
E
De Vidovich
G
G
Lazzaretti
M
M
d'Allio
G
G
Isola
M
M
Balestrieri
M
M
D'Angelo
E
E
Thyrion
F Zappoli
FZ
Scagnelli
P
P
Barale
F
F
Brambilla
P
P
D000293:Adolescent; D000328:Adult; D001883:Borderline Personality Disorder / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D002649:Child Abuse / Q000523:psychology; D004644:Emotions; D005260:Female; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology; D009415:Nerve Net / Q000503:physiopathology; D009483:Neuropsychological Tests; D010153:Paired-Associate Learning / Q000502:physiology; D010555:Personality Inventory; D011214:Practice, Psychological; D017397:Prefrontal Cortex / Q000503:physiopathology; D012094:Repression, Psychology; D055815:Young Adult