title: Influence of antegrade pulmonary blood flow on the hemodynamic performance of bidirectional cavopulmonary anastomosis: a numerical study.
abstract: The role and effect of preserved antegrade pulmonary blood flow (APBF) at the time of bidirectional cavopulmonary anastomosis (BCPA) in the management of single-ventricle physiology is controversial. We investigated the influence of APBF on the fluid dynamics of BCPA connection using computational fluid dynamics (CFD). Patient-specific, three-dimensional geometry of a BCPA connection with native pulmonary artery (PA) trunk was reconstructed and transient CFD simulations were done at four predetermined mean flow rates of PA trunk (0.5L/min, 1L/min, 1.5L/min and 2L/min). During a cardiac cycle, the flow ratio of left pulmonary artery (LPA)/right pulmonary artery (RPA) increased from 1.91 to 2.50, and average control volume power loss increased from 0.76 mW to 18.05 mW when the mean flow rate of PA trunk changed from 0.5L/min to 2L/min. The pulsatility of pressures in LPA, RPA and superior vena cava became more prominent as the amount of APBF increased. Local fluid structures in the connection area at four levels of APBF differed from each other.
authors: Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Children's Medical Center, Dongfang Road, Shanghai, China.
authors: Qi
authors: Q
authors: Sun
authors: Dawei
authors: D
authors: Wan
authors: Jinfen
authors: J
authors: Liu
authors: Yingzheng
authors: Y
authors: Liu
authors: Ming
authors: M
authors: Zhu
authors: Haifa
authors: H
authors: Hong
authors: Yanjun
authors: Y
authors: Sun
authors: Qian
authors: Q
authors: Wang
mesh_terms: D001783:Blood Flow Velocity; D003198:Computer Simulation; D018610:Heart Bypass, Right; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D011652:Pulmonary Circulation / Q000502:physiology*; D014683:Vena Cava, Superior / Q000502:physiology