title: [Comparision study pharmacokinetics of different source cinnamon acid].
abstract: OBJECTIVE
  To study relatively pharmacological activities of cinnamon acid in blood serum of rabbit administered cinnamon acid, cinnamon and Jingui Shenqi pills.
  
  
  METHODS
  RP-HPLC determine and analysis blood serum sample from rabbits administered cinnamon acid, cinnamon and Jingui Shenqi pills. Condition of colour spectrum was Symmetry C18 (3.9 mm x 150 mm, 5 microm) chromato bar, mobile phase was methanol-1% glacial acetic acid water-solution (45:55), flow rate was 0.8 mL x min(-1), temperature of bar was 35 degrees C, detection wave length was 285 nm. The serum pharmacokinetic parameters were calculated with 3p87.
  
  
  RESULTS
  Linear range of cinnamon acid is from 0.06-15 microg x mL(-1) (r = 0.9997), the lowest detectability is 0.054 microg x mL(-1). Pharmacokinetic process of cinnamon acid in rabbit could be all fitted to two-compartment model.
  
  
  CONCLUSIONS
  Sensitive and exclusive HPLC that adopt can exactly detect serum concentration in rabbits administerd cinnamon acid. Pharmacokinetic parameters of three conditions can reveal pharmacokinetics regularity of cinnamon acid in rabbit.
authors: Center of Research on Life Sciences and Environmental Sciences, Harbin University of Commerce Harbin 150076, China. lwldzd@163.com
authors: Wen-Lan
authors: WL
authors: Li
authors: Xiao-Dong
authors: XD
authors: Whang
authors: Yu-Bin
authors: YB
authors: Ji
authors: Zheng-Ting
authors: ZT
authors: Hu
authors: Xiao-Lei
authors: XL
authors: Ren
authors: Jia
authors: J
authors: Whang
mesh_terms: D000818:Animals; D002935:Cinnamomum zeylanicum / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D011817:Rabbits; D044967:Serum / Q000737:chemistry / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal