National evaluation of policies on individual financial conflicts of interest in Canadian academic health science centers.
BACKGROUND
Conflicts of interest (COI) in research are an important emerging topic of investigation and are frequently cited as a serious threat to the integrity of human participant research.


OBJECTIVE
To study financial conflicts of interest (FCOI) policies for individual investigators working in Canadian academic health centers.


METHODS
Survey instrument containing 61 items related to FCOI.


METHODS
All Canadian academic health science centers (universities with faculties of medicine, faculties of medicine and teaching hospitals) were requested to provide their three primary FCOI policies.


METHODS
Number of all centers and teaching hospitals with policies addressing each of the 61 items related to FCOI.


RESULTS
Only one item was addressed by all 74 centers. Thirteen items were present in fewer than 25% of centers. Fewer than one-quarter of hospitals required researchers to disclose FCOI to research participants. The role of research ethics boards (REBs) in hospitals was marginal.


CONCLUSIONS
Asking centers to identify only three policies may not have inclusively identified all FCOI policies in use. Additionally, policies at other levels might apply. For instance, all institutions receiving federal grant money must comply with the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans.


CONCLUSIONS
Canadian centers within the same level (for instance, teaching hospitals) differ significantly in the areas that their policies address and these policies differ widely in their coverage. Presently, no single policy in any Canadian center informs researchers about the broad range of individual FCOI issues. Canadian investigators need to understand the environment surrounding FCOI, be able to access and follow the relevant policies and be confident that they can avoid entering into a FCOI.
Lexchin
Joel
J
School of Health Policy and Management, York University, Toronto, ON, Canada. jlexchin@yorku.ca
Sekeres
Melanie
M
Gold
Jennifer
J
Ferris
Lorraine E
LE
Kalkar
Sunila R
SR
Wu
Wei
W
Van Laethem
Marleen
M
Chan
An-Wen
AW
Moher
David
D
Maskalyk
M James
MJ
Taback
Nathan
N
Rochon
Paula A
PA
D000046:Academic Medical Centers / Q000592:standards*; D002170:Canada; D016265:Conflict of Interest / Q000191:economics*; D003625:Data Collection; D030881:Disclosure / Q000592:standards*; D006801:Humans; D012106:Research / Q000191:economics / Q000592:standards