title: Aortic pressure augmentation as a marker of cardiovascular risk in obstructive sleep apnea syndrome.
abstract: Obstructive sleep apnea syndrome (OSAS) is associated with increases in cardiovascular morbidity and mortality. Vascular changes in individuals with OSAS have not been fully elucidated, however. The possible impact of OSAS on the extent of aortic pressure augmentation (AG), an indicator of cardiovascular risk, was investigated. Forty-five consecutive male patients aged 35 to 78 years (56.0+/-9.6 years) who were referred to the sleep clinic of Nagoya University Hospital for screening and treatment of OSAS and 71 age-matched healthy men were enrolled in the study. AG was derived from the pressure waveform measured at the radial artery by applanation tonometry. The number of apnea and hypopnea episodes per hour (apnea-hypopnea index [AHI]) was determined by standard polysomnography. AG was significantly greater in OSAS patients than in controls (9.0+/-4.1 vs. 6.4+/-3.4 mmHg, p<0.001), and it was significantly reduced in 19 OSAS patients treated with continuous positive airway pressure. AG was also significantly correlated with the AHI (r=0.562, p<0.001) and age (r=0.356, p=0.016) but not with the serum concentrations of low and high density lipoprotein-cholesterol, triglyceride, or glycosylated hemoglobin. Stepwise multiple regression analysis revealed that the AHI was the most significant contributing factor to the increased AG in OSAS patients (beta=0.109, r=0.530, p<0.001). OSAS may thus have an adverse effect on vascular function that can be ameliorated by appropriate treatment.
authors: Nagoya University School of Health Sciences, Higashi-kuNagoya, Japan. a-noda@met.nagoya-u.ac.jp
authors: Akiko
authors: A
authors: Noda
authors: Seiichi
authors: S
authors: Nakata
authors: Hiroshi
authors: H
authors: Fukatsu
authors: Yoshinari
authors: Y
authors: Yasuda
authors: Etsuko
authors: E
authors: Miyao
authors: Seiko
authors: S
authors: Miyata
authors: Fumihiko
authors: F
authors: Yasuma
authors: Toyoaki
authors: T
authors: Murohara
authors: Mitsuhiro
authors: M
authors: Yokota
authors: Yasuo
authors: Y
authors: Koike
mesh_terms: D000328:Adult; D000368:Aged; D001011:Aorta / Q000503:physiopathology*; D015415:Biomarkers; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology*; D045422:Continuous Positive Airway Pressure; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human