title: Evidences for complex formation between L-dabPNA and aegPNA.
abstract: Continuing our research on the development of nucleopeptides as ODN analogs for biomedical and bioengineering applications, here we report the synthesis and the chemical-physical characterization of a homoadenine hexamer based on a l-diaminobutyric acid (l-DABA) backbone (dabPNA), and its binding studies with a complementary aegPNA. We demonstrated by CD and UV experiments that the l-dabPNA binds the aegPNA forming a complex with good thermal stability, that we identified as a left-handed triplex.
authors: Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, I-80134 Napoli, Italy.
authors: Giovanni N
authors: GN
authors: Roviello
authors: Domenica
authors: D
authors: Musumeci
authors: Enrico M
authors: EM
authors: Bucci
authors: Mariangela
authors: M
authors: Castiglione
authors: Annalisa
authors: A
authors: Cesarani
authors: Carlo
authors: C
authors: Pedone
authors: Gennaro
authors: G
authors: Piccialli
mesh_terms: D000227:Adenine Nucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D000613:Aminobutyrates / Q000737:chemistry* / Q000378:metabolism*; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D005998:Glycine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000227:Adenine Nucleotides; D000613:Aminobutyrates; D020135:Peptide Nucleic Acids; C527043:aminoethylglycyl PNA; C051802:triplex DNA; D004247:DNA; D005998:Glycine