title: Combined line-cross and half-sib QTL analysis in Duroc-Pietrain population.
abstract: A Duroc-Pietrain resource population was built to detect quantitative trait loci (QTL) that affect growth, carcass composition, and pork quality. The data were analyzed by applying three least-squares Mendelian models: a line-cross (LC) model, a half-sib (HS) model, and a combined LC and HS model (CB), which enabled the detection of QTL that had fixed, equal, and different allele frequencies for alternate breed alleles, respectively. Permutation tests were performed to determine 5% chromosome-wide and 5% genome-wide threshold values. A total of 40 (137) QTL were detected at the 5% genome-wide (chromosome-wide) level for the 35 traits analyzed. Of the 137 QTL detected, 62 were classified as the LC type (LC-QTL), 47 as the HS type (HS-QTL), and 28 as the CB type (CB-QTL). The results indicate that implementation of a series of model-based framework is not only beneficial to detect QTL, but also provides us with a new and more robust interpretation from which further methodology could be developed.
authors: Animal Breeding and Husbandry Group, Institute of Animal Science, University of Bonn, Endenicher Allee 15, 53115 Bonn, Germany.
authors: Guisheng
authors: G
authors: Liu
authors: Jong Joo
authors: JJ
authors: Kim
authors: Elisebeth
authors: E
authors: Jonas
authors: Klaus
authors: K
authors: Wimmers
authors: Siriluck
authors: S
authors: Ponsuksili
authors: Eduard
authors: E
authors: Murani
authors: Chirawath
authors: C
authors: Phatsara
authors: Ernst
authors: E
authors: Tholen
authors: Heinz
authors: H
authors: Juengst
authors: Dawit
authors: D
authors: Tesfaye
authors: Ji Lan
authors: JL
authors: Chen
authors: Karl
authors: K
authors: Schellander
mesh_terms: D000818:Animals; D033481:Chromosomes, Mammalian / Q000235:genetics; D003433:Crosses, Genetic; D005260:Female; D016678:Genome / Q000235:genetics; D006863:Hydrogen-Ion Concentration; D008297:Male; D008460:Meat / Q000592:standards; D008957:Models, Genetic; D040641:Quantitative Trait Loci / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D013552:Swine / Q000145:classification* / Q000235:genetics* / Q000254:growth & development