The impact of enteral insulin-like growth factor 1 and nutrition on gut permeability and amino acid utilization.
The intestine serves numerous purposes. In addition to digestion and absorption, the intestine functions as an organ that provides specific and nonspecific protection against pathological bacteria and noxious agents. At birth, and certainly when birth occurs prematurely, these functions are not yet fully developed. This article addresses the specific needs of the neonatal gut to perform these functions adequately and describes efforts to modulate intestinal barrier function by preterm formula supplemented with insulin-like growth factor 1.
van Goudoever
Johannes B
JB
Division of Neonatology, Department of Pediatrics, Sophia Children's Hospital, Erasmus Medical Center, 3000 CB Rotterdam, The Netherlands. j.vangoudoever@erasmusmc.nl
Corpeleijn
Willemijn
W
Riedijk
Maaike
M
Schaart
Maaike
M
Renes
Ingrid
I
van der Schoor
Sophie
S
D000596:Amino Acids / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000254:growth & development* / Q000378:metabolism*; D006801:Humans; D007225:Infant Food; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology / Q000502:physiology*; D010539:Permeability; D014176:Protein Biosynthesis
D000596:Amino Acids; D007334:Insulin-Like Growth Factor I