title: Intensive pharmacologic treatment in patients with acute non ST-segment elevation myocardial infarction who did not undergo percutaneous coronary intervention.
abstract: BACKGROUND
  The aim of this study was to assess the impact of more aggressive pharmacological treatment on short-term clinical outcomes in patients with acute non ST-segment elevation myocardial infarction (NSTEMI) who do not undergo percutaneous coronary intervention (PCI).
  
  
  RESULTS
  The 924 NSTEMI patients treated with early conservative strategy (69.2+/-12.5 years, 637 males) in 50 hospitals that were high-volume centers with facilities for primary PCI were recruited to the Korean Acute Myocardial Infarction Registry (KAMIR) from November 2005 to August 2007. For all patients, the pharmacotherapy index based on the use of drugs during hospital stay was assessed (range of points 0-10). Primary endpoint was the combined in-hospital mortality and morbidity and major adverse cardiac events during 1 month of clinical follow-up. Of the patients, data from 847 who were followed-up for 1 month after discharge were analyzed. The rate of the primary endpoint decreased with an increase of the pharmacotherapy index and this result was similar in the low- and high-risk groups. In the multivariate analysis, low pharmacotherapy index (<or=4 points) was an independent predictor of the primary endpoint.
  
  
  CONCLUSIONS
  More intensive pharmacological treatment may improve short-term clinical outcomes in acute NSETMI patients who do not undergo PCI.
authors: Heart Center of Chonnam National University Hospital, Gwangju, Republic of Korea.
authors: Hae Chang
authors: HC
authors: Jeong
authors: Young Keun
authors: YK
authors: Ahn
authors: Myung Ho
authors: MH
authors: Jeong
authors: Shung Chull
authors: SC
authors: Chae
authors: Jong Hyun
authors: JH
authors: Kim
authors: In Whan
authors: IW
authors: Seong
authors: Young Jo
authors: YJ
authors: Kim
authors: Seung Ho
authors: SH
authors: Hur
authors: Dong Hoon
authors: DH
authors: Choi
authors: Taek Jong
authors: TJ
authors: Hong
authors: Jung Han
authors: JH
authors: Yoon
authors: Jae Young
authors: JY
authors: Rhew
authors: Jei Keon
authors: JK
authors: Chae
authors: Doo Il
authors: DI
authors: Kim
authors: In Ho
authors: IH
authors: Chae
authors: Bon Kwon
authors: BK
authors: Koo
authors: Byung Ok
authors: BO
authors: Kim
authors: Nae Hee
authors: NH
authors: Lee
authors: Jin Yong
authors: JY
authors: Hwang
authors: Seok Kyu
authors: SK
authors: Oh
authors: Myeong Chan
authors: MC
authors: Cho
authors: Kee Sik
authors: KS
authors: Kim
authors: Kyoung Tae
authors: KT
authors: Jeong
authors: Myoung Yong
authors: MY
authors: Lee
authors: Chong Jin
authors: CJ
authors: Kim
authors: Wook Sung
authors: WS
authors: Chung
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006328:Cardiac Catheterization; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality*; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate