Chicken breast attenuates high-intensity-exercise-induced decrease in rat sarcoplasmic reticulum Ca2+ handling.
This study was conducted to determine whether dietary chicken-breast extract (CBEX), a rich source of histidine-containing dipeptides, could modify exercise-induced changes in sarcoplasmic reticulum (SR) function. After 5 weeks of dietary CBEX, SR Ca2+-handling ability was examined in the vastus lateralis muscles of rats subjected to high-intensity running for 2.5 min. Dietary CBEX caused an approximately 15% and 45% increase (p<.01) in muscle carnosine and anserine concentrations, respectively. In resting muscles, depressions in SR Ca2+-ATPase activity were evoked by dietary CBEX without concomitant changes in SR Ca2+ uptake and release rates. The data confirm that high-intensity exercise depresses SR Ca2+ handling. In spite of the same run time, SR Ca2+ handling was reduced to a lesser degree in muscles of CBEX-containing-chow-fed rats than in standard-chow-fed rats (p<.05). These results suggest that dietary CBEX might attenuate deteriorations in SR Ca2+-handling ability that occur with high-intensity exercise.
Mishima
Takaaki
T
Preschool Education Department, Hachinohe Junior College, Hachinohe, Japan.
Yamada
Takashi
T
Sakamoto
Makoto
M
Sugiyama
Minako
M
Matsunaga
Satoshi
S
Maemura
Hirohiko
H
Shimizu
Muneshige
M
Takahata
Yoshihisa
Y
Morimatsu
Fimiki
F
Wada
Masanobu
M
D000818:Animals; D000861:Anserine / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002336:Carnosine / Q000378:metabolism; D002645:Chickens; D006639:Histidine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008460:Meat / Q000032:analysis*; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012420:Running; D012519:Sarcoplasmic Reticulum / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000378:metabolism
D006639:Histidine; D002336:Carnosine; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D000252:Calcium-Transporting ATPases; D000861:Anserine; D002118:Calcium