Preparation and evaluation of piroxicam-HPMCAS solid dispersions for ocular use.
The aim of the study was in vitro evaluation of piroxicam solid dispersions containing hydroxypropyl methylcellulose acetate succinate (HPMCAS-LF, -HF) as a carrier. Binary (piroxicam-HPMCAS) and ternary (piroxicam-HPMCAS-Carbopol 940) solid dispersions were prepared by spray-drying method. The morphological characteristics were investigated by scanning electron microscopy. X-ray diffraction and differential scanning calorimetry were employed to study physical and chemical properties. In vitro release was studied using a flow-through cell technique. Studies of dissolution rate of piroxicam from solid dispersions were carried out in comparison with corresponding physical mixtures and drug alone. The dissolution profiles depend on the presence of Carbopol 940 in solid dispersions.
Jachowicz
Renata
R
Department of Pharmaceutical Technology and Biopharmaceutics Jagiellonian University, Medical Collage Faculty of Pharmacyin Cracow, Poland.
Czech
Anna
A
D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000493:pharmacokinetics; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D005123:Eye / Q000378:metabolism*; D005128:Eye Diseases / Q000188:drug therapy; D006801:Humans; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D009883:Ophthalmic Solutions / Q000737:chemistry; D010316:Particle Size; D010894:Piroxicam / Q000737:chemistry / Q000493:pharmacokinetics*; D013499:Surface Properties; D044366:Transition Temperature; D014961:X-Ray Diffraction
D000180:Acrylic Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D005079:Excipients; D009883:Ophthalmic Solutions; D010894:Piroxicam; C006903:carbopol 940; C048331:hydroxypropylmethylcellulose acetate succinate; D008747:Methylcellulose