title: Simultaneous MR/PET imaging of the human brain: feasibility study.
abstract: The purpose of this study was to apply a magnetic resonance (MR) imaging-compatible positron emission tomographic (PET) detector technology for simultaneous MR/PET imaging of the human brain and skull base. The PET detector ring consists of lutetium oxyorthosilicate (LSO) scintillation crystals in combination with avalanche photodiodes (APDs) mounted in a clinical 3-T MR imager with use of the birdcage transmit/receive head coil. Following phantom studies, two patients were simultaneously examined by using fluorine 18 fluorodeoxyglucose (FDG) PET and MR imaging and spectroscopy. MR/PET data enabled accurate coregistration of morphologic and multifunctional information. Simultaneous MR/PET imaging is feasible in humans, opening up new possibilities for the emerging field of molecular imaging.
authors: Department of Diagnostic Radiology, University Hospital Tübingen, Hoppe-Seyler-Strasse 3, D-72076 Tübingen, Germany. heinz-peter.schlemmer@med.uni-tuebingen.de
authors: Heinz-Peter W
authors: HP
authors: Schlemmer
authors: Bernd J
authors: BJ
authors: Pichler
authors: Matthias
authors: M
authors: Schmand
authors: Ziad
authors: Z
authors: Burbar
authors: Christian
authors: C
authors: Michel
authors: Ralf
authors: R
authors: Ladebeck
authors: Kirstin
authors: K
authors: Jattke
authors: David
authors: D
authors: Townsend
authors: Claude
authors: C
authors: Nahmias
authors: Pradeep K
authors: PK
authors: Jacob
authors: Wolf-Dieter
authors: WD
authors: Heiss
authors: Claus D
authors: CD
authors: Claussen
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D005240:Feasibility Studies; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011859:Radiography; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18