SARS coronavirus and apoptosis.
1. The adenovirus-mediated overexpression of SARS coronavirus (SARS-CoV) spike protein (S) and its C-terminal domain (S2) induce apoptosis in Vero E6 cells. 2. Such apoptosis in Vero E6 cells is time- and dose-dependent. 3. The adenovirus-mediated overexpression of SARS-CoV N-terminal domain (S1) and other structural proteins, including E,M and N protein, do not induce apoptosis.
Chow
K Y
KY
Department of Zoology, The University of Hong Kong, Pokfulam, Hong Kong.
Yeung
Y S
YS
Hon
C C
CC
Zeng
F
F
Law
K M
KM
Leung
F C
FC
D000256:Adenoviridae / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis / Q000235:genetics* / Q000502:physiology; D016923:Cell Death / Q000235:genetics; D049109:Cell Proliferation; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D015967:Gene Expression Regulation, Viral; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D011336:Probability; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics* / Q000502:physiology; D012680:Sensitivity and Specificity; D045169:Severe Acute Respiratory Syndrome / Q000235:genetics / Q000821:virology*; D064370:Spike Glycoprotein, Coronavirus; D014161:Transduction, Genetic; D014709:Vero Cells / Q000166:cytology; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism; D015678:Viral Structural Proteins / Q000235:genetics / Q000378:metabolism
D008562:Membrane Glycoproteins; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins; D015678:Viral Structural Proteins; C578557:spike glycoprotein, SARS-CoV