Beta1 integrin in tissue remodelling and repair: from phenomena to concepts.
There is substantial molecular evidence for the involvement of beta1 integrin in tissue organisation and remodelling, which confers a key role in cell growth, differentiation, migration, and survival. This role has been, in part, highlighted using the transgenic approach which does little to define the more subtle functions such as those controlled by avidity regulation. Upon activation integrins in general, including beta1 integrin, are known to exhibit global structural rearrangement and exposure of ligand binding sites. Recent evidence has revealed a role of beta1 integrin modulation in tissue repair and regeneration. The anomalies and phenomena describing the roles of beta1 integrin in tissue remodelling are reviewed, as well as the tools which have been used to define the functions of beta1 integrin and its impact on our understanding of the diverse roles of beta1 integrin in remodelling. This eclectic mix of phenomena is conceptualised to form a unified hypothesis of a novel understanding of both tissue injury and repair.
Al-Jamal
Rehab
R
Division of Pathology, Breakthrough Breast Cancer Research Unit, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, United Kingdom. raljamal@staffmail.ed.ac.uk
Harrison
David J
DJ
D000494:Allosteric Regulation; D000818:Animals; D001665:Binding Sites; D002468:Cell Physiological Phenomena / Q000502:physiology; D006801:Humans; D019012:Integrin beta1 / Q000378:metabolism*; D008024:Ligands; D012038:Regeneration / Q000502:physiology*
D019012:Integrin beta1; D008024:Ligands