title: Histopathologic changes in guinea pig mastoid mucosa after topical mitomycin C application followed by mastoidectomy.
abstract: OBJECTIVE
  This study was performed to investigate the histopathologic changes observed in mastoid cavity of guinea pigs after the application of mitomycin C after mastoidectomy.
  
  
  METHODS
  The study was performed on 50 guinea pigs. Unilateral (right ear) mastoidectomy was performed on all guinea pigs. Twenty-five guinea pigs were separated as study group and the remaining were separated as control group. A mitomycin C-soaked sponge was placed in the mastoid cavities of the study group and a dry sponge was placed in those of the control group. Their mastoid cavities were examined histopathologically for absorbable sponge waste, abscess formation, fibrosis, vascularization, polymorphonuclear leukocyte infiltration, edema, lymphoplasmacytic inflammatory infiltration, and granulation tissue.
  
  
  RESULTS
  Absorbable sponge waste, abscess formation, fibrosis, vascularization, edema, and lymphoplasmacytic inflammatory infiltration were not significantly different between the groups. However, polymorphonuclear leukocyte infiltration and granulation tissue were statistically different between the groups.
  
  
  CONCLUSIONS
  Mitomycin C can be used after mastoidectomy to decrease the granulation tissue formation in ear discharges and to prevent the discharge.
authors: Department of Otorhinolaryngology, Kahramanmaraş Government Hospital, Kahramanmaraş, Turkey.
authors: Levent
authors: L
authors: Ozturk
authors: Irfan
authors: I
authors: Kaygusuz
authors: Nusret
authors: N
authors: Akpolat
authors: Erol
authors: E
authors: Keles
authors: Turgut
authors: T
authors: Karlidag
authors: Hayrettin Cengiz
authors: HC
authors: Alpay
authors: Sinasi
authors: S
authors: Yalcin
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004195:Disease Models, Animal; D006097:Granulation Tissue / Q000473:pathology*; D006168:Guinea Pigs; D007150:Immunohistochemistry; D008416:Mastoid / Q000187:drug effects* / Q000473:pathology* / Q000601:surgery; D016685:Mitomycin / Q000008:administration & dosage* / Q000009:adverse effects*; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D020556:Neutrophil Infiltration; D011182:Postoperative Care / Q000379:methods; D011336:Probability; D011897:Random Allocation; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D016685:Mitomycin