title: Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma.
abstract: Autotaxin (ATX) is a tumour cell motility-stimulating factor originally isolated from melanoma cell supernatants. ATX is identical to lysophospholipase D, which produces a bioactive lipid mediator, lysophosphatidic acid (LPA), from lysophosphatidylcholine. ATX is overexpressed in various malignancies, including Hodgkin lymphoma, and ATX may stimulate tumour progression via LPA production. The present study measured the serum ATX antigen levels in patients with haematological malignancies using a recently developed automated enzyme immunoassay. The serum ATX antigen levels in patients with B-cell neoplasms, especially follicular lymphoma (FL), were higher than those in healthy subjects. Serum ATX antigen levels in FL patients were associated with tumour burden and changed in parallel with the patients' clinical courses. The serum ATX antigen levels were little affected by inflammation, unlike the soluble interleukin-2 receptor and beta2-microglobulin levels. As expected, the plasma LPA levels in FL patients were correlated with the serum ATX antigen levels. Given that leukaemic tumour cells from FL patients expressed ATX, the shedding of ATX from lymphoma cells probably leads to the elevation of serum ATX antigen levels. Our results suggest that the serum ATX antigen level may be a promising and novel marker for FL.
authors: Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors: Akiko
authors: A
authors: Masuda
authors: Kazuhiro
authors: K
authors: Nakamura
authors: Koji
authors: K
authors: Izutsu
authors: Koji
authors: K
authors: Igarashi
authors: Ryunosuke
authors: R
authors: Ohkawa
authors: Masahiro
authors: M
authors: Jona
authors: Katsumi
authors: K
authors: Higashi
authors: Hiromitsu
authors: H
authors: Yokota
authors: Shinichi
authors: S
authors: Okudaira
authors: Tatsuya
authors: T
authors: Kishimoto
authors: Takuro
authors: T
authors: Watanabe
authors: Yukako
authors: Y
authors: Koike
authors: Hitoshi
authors: H
authors: Ikeda
authors: Yasushi
authors: Y
authors: Kozai
authors: Mineo
authors: M
authors: Kurokawa
authors: Junken
authors: J
authors: Aoki
authors: Yutaka
authors: Y
authors: Yatomi
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry; D008224:Lymphoma, Follicular / Q000097:blood*; D008245:Lysophospholipase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009097:Multienzyme Complexes / Q000032:analysis / Q000097:blood*; D043264:Phosphodiesterase I / Q000032:analysis / Q000097:blood*; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases / Q000032:analysis / Q000097:blood*; D018709:Statistics, Nonparametric; D000099189:Lysophospholipase D
chemical_list: D014408:Biomarkers, Tumor; D008245:Lysophospholipase; D009097:Multienzyme Complexes; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases; D000099189:Lysophospholipase D