title: Apolipoprotein E-epsilon 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV.
abstract: Apolipoprotein E (APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes. We investigated the potential association between the APOE-epsilon 4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-epsilon 4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95% CI 2.4 to 28.5). To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-epsilon 4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV.
authors: Department of Genito-Urinary Medicine, Hawthorn House, Heartlands Hospital, Bordsley Green East, Birmingham B9 5SS, UK. ashini@doctors.net.uk
authors: A N
authors: AN
authors: Jayasuriya
authors: R F
authors: RF
authors: Itzhaki
authors: M A
authors: MA
authors: Wozniak
authors: R
authors: R
authors: Patel
authors: E J
authors: EJ
authors: Smit
authors: R
authors: R
authors: Noone
authors: G
authors: G
authors: Gilleran
authors: S
authors: S
authors: Taylor
authors: D J
authors: DJ
authors: White
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications*; D000483:Alleles; D053327:Apolipoprotein E4 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006558:Herpes Genitalis / Q000150:complications*; D018258:Herpesvirus 2, Human / Q000235:genetics*; D006801:Humans; D008297:Male
chemical_list: D053327:Apolipoprotein E4