title: Human bone marrow native mesenchymal stem cells.
abstract: The adult bone marrow (BM) has been generally considered to be composed of hematopoietic tissue and the associated supporting stroma. There is accumulating evidence that a subset of multipotential cells exists within the latter compartment, commonly referred to as mesenchymal stem cells (MSCs). These cells can be easily expanded ex vivo and induced to differentiate into skeletal connective tissues, thereby emerging as attractive candidates for various therapeutic applications. Despite the extensive in vitro characterization of MSCs, at present, little is known about their in vivo properties or anatomical location. Here we review the efficacy of the different surface markers used to isolate BM MSCs and highlight current data suggesting that BM MSCs in situ are associated with vascular sinus walls and probably belong to the family of vascular smooth muscle cells.
authors: Institut National de la Recherche et Santé Médicale (INSERM), Equipe ESPRI/EA-3855, University François Rabelais, Faculty of Medicine, Tours, France. pontikoglou@yahoo.com
authors: Charalampos
authors: C
authors: Pontikoglou
authors: Bruno
authors: B
authors: Delorme
authors: Pierre
authors: P
authors: Charbord
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001853:Bone Marrow / Q000473:pathology; D001854:Bone Marrow Cells / Q000166:cytology*; D002454:Cell Differentiation; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D051379:Mice; D008954:Models, Biological; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D010641:Phenotype; D051381:Rats; D044968:Regenerative Medicine / Q000379:methods; D013234:Stem Cells; D023822:Tissue Engineering / Q000379:methods
chemical_list: D015415:Biomarkers