Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones).
The synthesis and in-vitro antiprotozoal evaluation of novel N(4)-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thione) (bis-THTT) derivatives from N(4)-(benzyl)spermidine is disclosed. Several of the new bis-THTT have in-vitro activities against L. donovani and T. cruzi that are comparable or superior to those of currently employed protozoocidal agents.
Coro
Julieta
J
Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, Habana, Cuba.
Little
Susan
S
Yardley
Vanessa
V
Suárez
Margarita
M
Rodríguez
Hortensia
H
Martín
Nazario
N
Perez-Pineiro
Rolando
R
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D007893:Leishmania donovani / Q000187:drug effects; D013095:Spermidine / Q000737:chemistry; D013329:Structure-Activity Relationship; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
D000981:Antiprotozoal Agents; D013871:Thiones; D013095:Spermidine