The use of mesenchymal (skeletal) stem cells for treatment of degenerative diseases: current status and future perspectives.
Human bone marrow derived-mesenchymal (skeletal) stem (MSC) cells are a group of non-hematopoietic stem cells residing in the perivascular niches in bone marrow. These cells have the capacity to differentiate mainly into mesoderm-type cells such as osteoblasts, chondrocytes and adipocytes and possibly but not proven to non-mesodermal cell types. Recently, there has been an increased interest in understanding the biology of MSC due to their potential use in cell-based therapy for multiple degenerative diseases. Here, we will provide an update on the current status of these novel therapeutic opportunities. J. Cell. Physiol. 218: 9-12, 2009. (c) 2008 Wiley-Liss, Inc.
Abdallah
Basem M
BM
Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital & Medical Biotechnology Centre, University of Southern Denmark, Odense, Denmark. babdallah@health.sdu.dk
Kassem
Moustapha
M
D000818:Animals; D001847:Bone Diseases / Q000628:therapy; D001861:Bone Regeneration; D002318:Cardiovascular Diseases / Q000628:therapy; D002469:Cell Separation; D006086:Graft vs Host Disease / Q000517:prevention & control / Q000628:therapy; D006410:Hematopoiesis; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods* / Q000639:trends; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D039902:Multipotent Stem Cells / Q000166:cytology / Q000637:transplantation; D017154:Stromal Cells / Q000166:cytology / Q000637:transplantation; D023822:Tissue Engineering