Hepatitis G virus.
A number of new hepatitis viruses (G, TT, SEN) were discovered late in the past century. We review the data available in the literature and our own findings suggesting that the new hepatitis G virus (HGV), disclosed in the late 1990s, has been rather well studied. Analysis of many studies dealing with HGV mainly suggests the lymphotropicity of this virus. HGV or GBV-C has been ascertained to influence course and prognosis in the HIV-infected patient. Until now, the frequent presence of GBV-C in coinfections, hematological diseases, and biliary pathology gives no grounds to determine it as an "accidental tourist" that is of no significance. The similarity in properties of GBV-C and hepatitis C virus (HCV) offers the possibility of using HGV, and its induced experimental infection, as a model to study hepatitis C and to develop a hepatitis C vaccine.
Reshetnyak
Vasiliy Ivanovich
VI
Scientific Research Institute of General Reanimatology, Russia Academy of Medical Sciences, Moscow 107031, Russia. v_reshetnyak@yahoo.com
Karlovich
Tatiana Igorevna
TI
Ilchenko
Ljudmila Urievna
LU
D029407:GB virus C / Q000145:classification / Q000235:genetics / Q000254:growth & development / Q000276:immunology / Q000302:isolation & purification; D016679:Genome, Viral; D005838:Genotype; D006508:Hepatitis Antibodies / Q000097:blood; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000453:epidemiology / Q000266:history / Q000821:virology; D049673:History, 20th Century; D006801:Humans; D008099:Liver / Q000473:pathology / Q000821:virology; D012367:RNA, Viral / Q000097:blood; D018523:Tropism; D019562:Viral Load; D014779:Virus Replication
D006508:Hepatitis Antibodies; D012367:RNA, Viral