B and T lymphocyte attenuator regulates T cell survival in the lung.
The initiation, intensity, and duration of T cell-directed inflammatory responses are dependent upon the coordination of both activating and inhibitory signals mediated by specific receptors on the T lymphocyte. The recently described receptor, B and T lymphocyte attenuator (BTLA), has been demonstrated to have an important role in limiting the duration of inflammation in a murine model of allergic asthma. In this study, we have examined the role of BTLA on the proliferation, recruitment, and survival of T cells in response to inhaled allergen. We find that there is decreased cell death in T cells from BTLA-deficient mice, whereas proliferation and recruitment to the lungs are unchanged. Thus, the regulation of cell death through BTLA signaling is a key determinant of the inflammatory response in the lung.
Deppong
Christine
C
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Degnan
Jessica M
JM
Murphy
Theresa L
TL
Murphy
Kenneth M
KM
Green
Jonathan M
JM
D000485:Allergens / Q000008:administration & dosage / Q000276:immunology; D000818:Animals; D016923:Cell Death; D002465:Cell Movement / Q000276:immunology; D049109:Cell Proliferation; D002470:Cell Survival; D006967:Hypersensitivity / Q000276:immunology; D007249:Inflammation / Q000276:immunology*; D008168:Lung / Q000276:immunology* / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D011971:Receptors, Immunologic / Q000172:deficiency / Q000502:physiology*; D013601:T-Lymphocytes
D000485:Allergens; C488868:BTLA protein, mouse; D011971:Receptors, Immunologic