Plasmid-mediated quinolone resistance determinants qnrA, qnrB, and qnrS among clinical isolates of Enterobacteriaceae in a Korean hospital.
Screening of 368 consecutive nonreplicate clinical isolates of Enterobacteriaceae resistant to nalidixic acid and at least one extended-spectrum beta-lactam revealed the presence of qnrA, qnrB, and qnrS determinants, and identified novel qnrB variants, in Citrobacter freundii isolates. This study also revealed, for the first time, the linkage of qnrB, armA, and extended-spectrum and/or AmpC-type beta-lactamase genes on large conjugative plasmids.
Tamang
Migma Dorji
MD
Department of Microbiology, Kyungpook National University School of Medicine, Jung-gu, Daegu, Republic of Korea.
Seol
Sung Yong
SY
Oh
Jae-Young
JY
Kang
Hee Young
HY
Lee
Je Chul
JC
Lee
Yoo Chul
YC
Cho
Dong Taek
DT
Kim
Jungmin
J
D000595:Amino Acid Sequence; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000382:microbiology; D005798:Genes, Bacterial; D006785:Hospitals, University; D006801:Humans; D007723:Korea; D008969:Molecular Sequence Data; D015363:Quinolones / Q000494:pharmacology*; D011815:R Factors / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics
D017931:DNA Primers; D004269:DNA, Bacterial; D015363:Quinolones; D001618:beta-Lactamases