title: Effect of 17beta-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats.
abstract: The present study evaluated 17beta-estradiol (17betaE(2)) (2.5 mg/kg sc) effects on bilateral OBX-induced behavioral changes and oxidative stress. OBX in male Wistar rats produced an increase in lipid peroxidation products and a decline in reduced glutathione (GSH) content and glutathione peroxidase (GSH-Px) activity, together with an increase in caspase-3 activity. Additionally, OBX triggered changes of behavior such as an enhancement of immobility time in the forced swim test and hyperactivity in the open field test. These changes were reversed by treatment with 17betaE(2) (14 days). Our results reveled that 17betaE(2) has a protective effect against oxidative stress, cell damage and behavioral changes induced by OBX, and present antidepressant and antianxiety properties.
authors: Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba Córdoba, Spain.
authors: Inmaculada
authors: I
authors: Tasset
authors: José
authors: J
authors: Peña
authors: Ignacio
authors: I
authors: Jimena
authors: Montserrat
authors: M
authors: Feijóo
authors: María
authors: M
authors: Del Carmen Muñoz
authors: Pedro
authors: P
authors: Montilla
authors: Isaac
authors: I
authors: Túnez