Effect of weight loss through laparoscopic gastric banding on blood pressure, plasma renin activity and aldosterone levels in morbid obesity.
OBJECTIVE
Several mechanisms are probably involved in obesity-related hypertension. This study was aimed to investigate the effect of significant weight loss on blood pressure and plasma renin activity (PRA) and aldosterone levels, other then on metabolic profile, in normotensive and hypertensive obese subjects.


RESULTS
Forty hypertensive and 55 normotensive obese subjects were studied under basal conditions and again 1 year after significant weight loss obtained through laparoscopic adjustable gastric banding (LAGB). Weight, waist circumference, blood glucose, insulin, electrolytes (Na and K), lipids and supine and upright PRA and aldosterone were evaluated. All parameters evaluated improved, except for total cholesterol, and electrolytes that did not change. Blood pressure decreased in hypertensive subjects, with a concordant decrease in PRA and supine aldosterone levels, not observed in normotensive patients.


CONCLUSIONS
Weight loss is associated with reduction of blood pressure and of PRA and aldosterone levels in obese hypertensive subjects.
Dall'Asta
C
C
Dipartimento di Medicina, Chirurgia e Odontoiatria, Università degli Studi di Milano, Ospedale San Paolo, Via A. Di Rudinì 8, 20142 Milano, Italy. chiara.dallasta@unimi.it
Vedani
P
P
Manunta
P
P
Pizzocri
P
P
Marchi
M
M
Paganelli
M
M
Folli
F
F
Pontiroli
A E
AE
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D050110:Bariatric Surgery / Q000379:methods*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015536:Down-Regulation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D010535:Laparoscopy; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D011188:Potassium / Q000097:blood; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System; D012964:Sodium / Q000097:blood; D013997:Time Factors; D016896:Treatment Outcome; D055105:Waist Circumference; D015431:Weight Loss
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D011188:Potassium