title: A randomized clinical trial with two enteral diabetes-specific supplements in patients with diabetes mellitus type 2: metabolic effects.
abstract: The aim of this study was to investigate whether two specific diabetes enteral formulas could improve nutritional as well as metabolic parameters in elderly patients with diabetes mellitus type 2. A population of 30 elderly patients with diabetes mellitus type 2 with recent weight loss was recruited. At basal time diabetic patients were asked to consume randomly two cans per day of two different specially designed high monounsaturated fatty acid diabetes-specific supplement: one with 49.95% of calories provided by fats (I), the second with a 34% of calories provided by fats (II), for a ten week period. A significative decrease of glucose (119.8 +/- 42 vs 95.1 +/- 16.8 mg/dl: p < 0.05) and Hbalc (8.2 +/- 2.8 vs 5.8 +/- 0.7%: p < 0.05) levels was observed in group I with a significant increase in serum albumin levels (3.1 +/- 0.8 vs 3.5 +/- 0.5 g/dl: p < 0.05). A significant increase of serum albumin (3.1 +/- 0.4 vs 3.7 +/- 0.6 g/dl: p < 0.05) and total proteins (6.3 +/- 0.5 vs 6.9 +/- 0.3 g/dl: p < 0.05) was observed in group II. Patients of group II had a significant improvement in weight (56.5 +/- 16 vs 58.3 +/- 15 kg: p < 0.05), body mass index (21.8 +/- 5.6 vs 22.5 +/- 5.3 kg/m2: p < 0.05) and fat mass (15.7 +/- 6.4 vs 16.9 +/- 6.2 kg: p < 0.05). In conclusion, high monounsaturated fatty acid diabetes-specific enteral supplement improved glucose, HbAlc and albumin levels. A diabetes-specific supplement with lower fat percentage than the first improved weight and protein levels without significative metabolic effects.
authors: Institute of Endocrinology and Nutrition, Medicine School, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es
authors: D A
authors: DA
authors: de Luis
authors: O
authors: O
authors: Izaola
authors: R
authors: R
authors: Aller
authors: L
authors: L
authors: Cuellar
authors: M C
authors: MC
authors: Terroba
authors: T
authors: T
authors: Martin
authors: G
authors: G
authors: Cabezas
authors: S
authors: S
authors: Rojo
authors: M
authors: M
authors: Domingo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy*; D004041:Dietary Fats / Q000008:administration & dosage*; D004750:Enteral Nutrition; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012709:Serum Albumin / Q000378:metabolism; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D005229:Fatty Acids, Monounsaturated; D006442:Glycated Hemoglobin; D012709:Serum Albumin