[The morphofunctional characteristics of proteins of nucleolar organizers in uterine smooth muscle tumors].
The authors have shown the activity of argyrophylic nucleolar organizer region proteins (Ag-NOR-proteins) in the uterine leiomyomas of varying histological structure and determined their relationship to the growth rate, size, and site of a node and endometrial pathology. The investigation indicat yomas with significant sclerosis, 4.32 +/- 0.1 in simple leiomyomas, and 6.2 +/- 0.2 in cell leiomyomas (r = 0.58). In menopause, myomas with significant sclerosis and hyalinosis were characterized with a small number of Ag-NOR (1.44 +/- 0.04). Thus, the organizers numbered 12.1 +/- 0.5 and 21.7 +/- 1.0 in high- and low-grade sarcomas, respectively, which may be used in the differential diagnosis of cellular, bizarre, mitotically active leiomyomas and leiomyosarcomas.
Bobrov
I P
IP
Avdalian
A M
AM
Lazarev
A F
AF
Klimachev
V V
VV
Klimacheva
T B
TB
Mishchenko
E V
EV
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005498:Follicular Phase / Q000378:metabolism; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism* / Q000473:pathology*; D007890:Leiomyosarcoma / Q000378:metabolism* / Q000473:pathology*; D008183:Luteal Phase / Q000378:metabolism; D008593:Menopause / Q000378:metabolism; D008875:Middle Aged; D009214:Myoma / Q000378:metabolism / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D009697:Nucleolus Organizer Region / Q000378:metabolism* / Q000473:pathology; D012598:Sclerosis; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000473:pathology*
D009363:Neoplasm Proteins; D009687:Nuclear Proteins