title: Simultaneous Doppler tracing of the mitral inflow and annular motion provides a useful means of evaluating left ventricular diastolic function.
abstract: BACKGROUND
  In this study, we evaluated the feasibility and clinical usefulness of TS(E-E(') ), the time interval between the onsets of early diastolic mitral inflow velocity (E) and mitral annular velocity (E'), obtained by simultaneously tracing E and E', in terms of evaluating diastolic function.
  
  
  METHODS
  By the diastolic functional status, 105 patients were allocated to abnormal relaxation, pseudonormal filling (PN), or normal diastolic function groups (n = 30, 43, and 32, respectively). The TS(E-E(') ) was measured in the same cardiac cycle by the pulsed-wave Doppler (PWD) tracing of mitral inflow near the septal annulus with appropriate filter and gain settings.
  
  
  RESULTS
  TS(E-E(') ) was prolonged in the PN group versus the normal group (34.1 +/- 12.2 msec versus 12.1 +/- 8.5 msec, p< or =0.001). The area under the receiver operating characteristic curve of TS(E-E(') ) for the detection of PN was 0.91 (95% confidence interval [CI]; 0.85 approximately 0.97, p<0.001), and 24.0 msec was determined to be the optimal cut-off value (specificity 83.7%, sensitivity 90.3%).
  
  
  CONCLUSIONS
  Simultaneous measurement of TS(E-E(') ) is feasible and clinically applicable for the grading of diastolic dysfunction (DD).
authors: Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Jin-Oh
authors: JO
authors: Choi
authors: Seung Woo
authors: SW
authors: Park
authors: Dae-Hee
authors: DH
authors: Shin
authors: Hyejin
authors: H
authors: Han
authors: Sungwon
authors: S
authors: Cho
authors: Jun Hyung
authors: JH
authors: Kim
authors: Young Bin
authors: YB
authors: Song
authors: Sang-Chol
authors: SC
authors: Lee
mesh_terms: D003971:Diastole / Q000502:physiology*; D004452:Echocardiography; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging*; D012680:Sensitivity and Specificity; D016277:Ventricular Function, Left / Q000502:physiology*