Macroautophagy: a mechanism for mediating cell death or for promoting cell survival?
Macroautophagy is a ubiquitous mechanism for the bulk removal of macromolecules and cell organelles from the cell. Periyasamy-Thandavan and colleagues report that cisplatin activates autophagy in renal tubular cells and that autophagy plays a role in decreasing apoptosis of tubular cells induced by cisplatin. This finding provides novel evidence that autophagy may play a role in ameliorating the effects of acute injury on the kidney.
Lieberthal
Wilfred
W
Stony Brook University Hospital, Department of Medicine, Stony Brook, New York, USA. wlieberthal@notes.cc.sunysb.edu
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity; D001343:Autophagy / Q000187:drug effects / Q000502:physiology*; D016923:Cell Death / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology*; D002945:Cisplatin / Q000633:toxicity; D006801:Humans; D007668:Kidney / Q000293:injuries / Q000473:pathology; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology
D000970:Antineoplastic Agents; D002945:Cisplatin