Highly enantioselective Friedel-Crafts reaction of indoles with 2-enoylpyridine 1-oxides catalyzed by chiral pyridine 2,6-bis(5',5'-diphenyloxazoline)-Cu(II) complexes.
The catalytic enantioselective Friedel-Crafts reaction of indoles with 2-enoylpyridine 1-oxides has been studied in the presence of chiral pyridine 2,6-bis(5',5'-diphenyloxazoline)-Cu(II) complexes. The reaction furnished alkylated indoles in excellent yields (up to 97%) and enantioselectivities (up to 99% ee).
Singh
Pradeep K
PK
Department of Chemistry, Indian Institute of Technology Kanpur, India 208 016.
Singh
Vinod K
VK