title: Ten-year recurrence rates in young women with breast cancer by locoregional treatment approach.
abstract: OBJECTIVE
  Young women with breast cancer have higher locoregional recurrence (LRR) rates than older patients. The goal of this study is to determine the impact of locoregional treatment strategy, breast-conserving therapy (BCT), mastectomy alone (M), or mastectomy with adjuvant radiation (MXRT), on LRR for patients 35 years or younger.
  
  
  METHODS
  Data for 668 breast cancers in 652 young patients with breast cancer were retrospectively reviewed; 197 patients were treated with BCT, 237 with M, and 234 with MXRT.
  
  
  RESULTS
  Median follow-up for all living patients was 114 months. In the entire cohort, 10-year actuarial LRR rates varied by locoregional treatment: 19.8% for BCT, 24.1% for M, and 15.1% for MXRT (p = 0.05). In patients with Stage II disease, 10-year actuarial LRR rates by locoregional treatment strategy were 17.7% for BCT, 22.8% for M, and 5.7% for MXRT (p = 0.02). On multivariate analysis, M (hazard ratio, 4.45) and Grade III disease (hazard ratio, 2.24) predicted for increased LRR. In patients with Stage I disease, there was no difference in LRR rates based on locoregional treatment (18.0% for BCT, 19.8% for M; p = 0.56), but chemotherapy use had a statistically significant LRR benefit (13.5% for chemotherapy, 27.9% for none; p = 0.04).
  
  
  CONCLUSIONS
  Young women have high rates of LRR after breast cancer treatment. For patients with Stage II disease, the best locoregional control rates were achieved with MXRT. For patients with Stage I disease, similar outcomes were achieved with BCT and mastectomy; however, chemotherapy provided a significant benefit to either approach.
authors: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors: Beth M
authors: BM
authors: Beadle
authors: Wendy A
authors: WA
authors: Woodward
authors: Susan L
authors: SL
authors: Tucker
authors: Elesyia D
authors: ED
authors: Outlaw
authors: Pamela K
authors: PK
authors: Allen
authors: Julia L
authors: JL
authors: Oh
authors: Eric A
authors: EA
authors: Strom
authors: George H
authors: GH
authors: Perkins
authors: Welela
authors: W
authors: Tereffe
authors: Tse-Kuan
authors: TK
authors: Yu
authors: Funda
authors: F
authors: Meric-Bernstam
authors: Jennifer K
authors: JK
authors: Litton
authors: Thomas A
authors: TA
authors: Buchholz
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D018275:Carcinoma, Lobular / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008408:Mastectomy / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D055815:Young Adult