title: Ocular motor anatomy in a case of interrupted saccades.
abstract: Saccades normally place the eye on target with one smooth movement. In late-onset Tay-Sachs (LOTS), intrasaccadic transient decelerations occur that may result from (1) premature omnipause neuron (OPN) re-activation due to malfunction of the latch circuit that inhibits OPNs for the duration of the saccade or (2) premature inhibitory burst neuron (IBN) activation due to fastigial nucleus (FN) dysregulation by the dorsal cerebellar vermis. Neuroanatomic analysis of a LOTS brain was performed. Purkinje cells were absent and gliosis of the granular cell layer was present in the dorsal cerebellar vermis. Deep cerebellar nuclei contained large inclusions. IBNs were present with small inclusions. The sample did not contain the complete OPN region; however, neurons in the OPN region contained massive inclusions. Pathologic findings suggest that premature OPN re-activation and/or inappropriate firing of IBNs may be responsible for interrupted saccades in LOTS. Cerebellar clinical dysfunction, lack of saccadic slowing, and significant loss of cerebellar cells suggest that the second cause is more likely.
authors: Rush Medical Center, Chicago, IL, USA. janet_rucker@rush.edu
authors: Janet C
authors: JC
authors: Rucker
authors: R John
authors: RJ
authors: Leigh
authors: Lance M
authors: LM
authors: Optican
authors: Edward L
authors: EL
authors: Keller
authors: Jean A
authors: JA
authors: Bu Ttner-Ennever
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000033:anatomy & histology / Q000473:pathology* / Q000502:physiology / Q000503:physiopathology*; D009474:Neurons / Q000502:physiology*; D009801:Oculomotor Muscles / Q000502:physiology; D012438:Saccades / Q000502:physiology*; D013661:Tay-Sachs Disease / Q000473:pathology / Q000503:physiopathology; D014795:Visual Pathways / Q000502:physiology