title: No evidence for object alternation impairment in obsessive-compulsive disorder (OCD).
abstract: Recent neuroimaging studies have consistently ascribed the orbito-frontal cortex (OFC) a pivotal role in the pathogenesis of obsessive-compulsive disorder (OCD). Cognitive tests presumed sensitive to this region, such as the Object Alternation Task (OAT), are considered important tools to verify this assumption and to investigate the impact of cortical dysfunction on behavior. The aim of the present study was to assess if patients with OCD show enhanced perseveration errors on the OAT relative to healthy controls taking into account several potential moderators, especially comorbid depression and OCD subtype. Thirty-five OCD patients and 18 healthy controls underwent the OAT as well as the Trail-Making Tests (TMT) A and B. In line with prior studies, OCD patients were slowed on both TMT tasks. In contrast, samples performed similarly on the OAT. While the latter finding does not invalidate the assumption that the OFC is affected in OCD, dysfunctions involving this region may be more subtle than often claimed and likely encompass only a small subset of functional domains hosted in the OFC.
authors: University Medical Center Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Martinistrasse 52, 20246 Hamburg, Germany. moritz@uke.uni-hamburg.de
authors: Steffen
authors: S
authors: Moritz
authors: Lena
authors: L
authors: Jelinek
authors: Birgit
authors: B
authors: Hottenrott
authors: Ruth
authors: R
authors: Klinge
authors: Sarah
authors: S
authors: Randjbar
mesh_terms: D000328:Adult; D003071:Cognition; D003863:Depression / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000523:psychology*; D014145:Trail Making Test