Mechanisms of synaptic depression triggered by metabotropic glutamate receptors.
Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.
Bellone
C
C
Dept. of Basic Neurosciences, Medical Faculty, University of Geneva, 1211 Geneva, Switzerland.
Lüscher
C
C
Mameli
M
M
D000818:Animals; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D006801:Humans; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D020033:Protein Isoforms / Q000378:metabolism; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
D020033:Protein Isoforms; D018094:Receptors, Metabotropic Glutamate