Polymorphisms of the Z protein protease inhibitor and risk of venous thromboembolism: a meta-analysis.
Two nonsense polymorphisms of Z-dependent protease inhibitor (ZPI; Serpina10) have been identified. To assess the risk of venous thromboembolism (VTE) associated with W303x and R67X Serpina10 mutations, we performed a meta-analysis of studies comparing the prevalence of these two mutations in VTE patients and in controls Odds Ratios (ORs) and 95% confidence intervals (CIs) were calculated for each trial and pooled using a random-effects model. Five studies involving 5000 patients were included. R67X and W303X mutations of Serpina10 were not associated with increased VTE risk (OR 1.63; 95% CI 0.84, 3.16 and OR 1.21; 95% CI 0.29, 4.98 respectively).
Dentali
Francesco
F
Department of Clinical Medicine, Insubria University, Varese, Italy. fdentali@libero.it
Gianni
Monica
M
Lussana
Federico
F
Squizzato
Alessandro
A
Cattaneo
Marco
M
Ageno
Walter
W
D016022:Case-Control Studies; D016001:Confidence Intervals; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D015995:Prevalence; D012306:Risk; D015843:Serpins / Q000235:genetics*; D054556:Venous Thromboembolism / Q000235:genetics*
C416370:SERPINA10 protein, human; D015843:Serpins