The eldest of older adults living with HIV: response and adherence to highly active antiretroviral therapy.
OBJECTIVE
The study objective was to analyze the characteristics and the response to therapy in the eldest of the older adults living with human immunodeficiency virus.


METHODS
The study included a cohort of patients with human immunodeficiency virus aged 55 years or more on initiating highly active antiretroviral therapy (HAART). Immunologic and virologic response, morbidity, and mortality were assessed. Patients were categorized as aged less than 65 years and 65 years or more.


RESULTS
A total of 112 patients were included (82 patients aged<65 years and 30 patients aged> or =65 years). There were no differences between the age groups in baseline characteristics, survival, and virologic response. There was a trend toward better adherence and a lower CD4+ cell increase after HAART in the older group.


CONCLUSIONS
A relationship was found between lower CD4+ cell increase after HAART and advanced age. We found the best adherence to treatment in the eldest of the older adults, and this has been shown to be the only protective independent factor related to virologic failure.
Brañas
Fátima
F
Department of Geriatric Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain. fbranas@hotmail.com
Berenguer
Juan
J
Sánchez-Conde
Matilde
M
López-Bernaldo de Quirós
Juan Carlos
JC
Miralles
Pilar
P
Cosín
Jaime
J
Serra
José Antonio
JA
D000367:Age Factors; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D016009:Chi-Square Distribution; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D018709:Statistics, Nonparametric; D015996:Survival Rate