title: Perforating necrobiosis lipoidica in a girl with type 1 diabetes mellitus: a new case reported.
abstract: Necrobiosis lipoidica is an idiopathic dermatological condition that is strongly associated with diabetes mellitus. It is more commonly seen in women than men. The average age of onset is 30-40 years. Necrobiosis Lipoidica diabeticorum is an extremely rare finding in childhood diabetes. We describe the case of a 13-year-old girl who has had type 1 diabetes mellitus since she was 8 years old. The patient presented with 2 well-defined, persistent plaques with a depressed central area and elevated purple peripheral ring, one on the right thigh and the other over the lateral left leg. Histopathologic evaluation of the patient's biopsy confirmed the diagnosis of necrobiosis lipoidica with transfollicular elimination. Our patient is the second pediatric case described with perforating necrobiosis lipoidica. We review the literature and discuss clinical features, several complications, and the most recent treatment options for necrobiosis lipoidica in diabetic children.
authors: Dermatology Department, Military Hospital of Tunis, Tunis, Tunisia.
authors: Houda
authors: H
authors: Hammami
authors: Soumaya
authors: S
authors: Youssef
authors: Kahena
authors: K
authors: Jaber
authors: Mohamed Raouf
authors: MR
authors: Dhaoui
authors: Nejib
authors: N
authors: Doss
mesh_terms: D000293:Adolescent; D001707:Biopsy, Needle; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007328:Insulin / Q000627:therapeutic use; D035002:Lower Extremity; D009335:Necrobiosis Lipoidica / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D007328:Insulin