Antifungal saponins from Paris polyphylla Smith.
Three steroidal saponins, including one new and two known compounds, were isolated from the rhizomes of Paris polyphylla Smith. One- and two-dimensional NMR, LC-MS, and interpretation of hydrolytic cleavage experiments led to the identification of the structure of the new saponin as ( 25R)-spirost-5-ene-3 beta,17 alpha-diol (pennogenin) 3- O-{ O- alpha- L-rhamnopyranosyl-(1-->2)- O-[ O- beta-xylopyranosyl-(1-->5)- alpha- L-arabinofuranosyl-(1-->4)]- beta- D-glucopyranoside}. The isolated saponins were evaluated for their antifungal activity against Cladosporium cladosporioides and Candida species and showed comparable activity to chemicals used in some commercial products.
Deng
Dawei
D
HortResearch, Ruakura Research Centre, Hamilton, New Zealand. ddeng@hortresearch.co.nz
Lauren
Denis R
DR
Cooney
Janine M
JM
Jensen
Dwayne J
DJ
Wurms
Kirstin V
KV
Upritchard
Jenine E
JE
Cannon
Richard D
RD
Wang
Ming Zhong
MZ
Li
Ming Zhang
MZ
D000935:Antifungal Agents / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D019668:Liliaceae / Q000737:chemistry*; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*
D000935:Antifungal Agents; D004365:Drugs, Chinese Herbal; D012503:Saponins