An ApoA-I mimetic peptide high-density-lipoprotein-based MRI contrast agent for atherosclerotic plaque composition detection.
Cardiovascular disease is one of the prime causes of mortality throughout the world and there is a need for targeted and effective contrast agents to allow noninvasive imaging of the cholesterol-rich atherosclerotic plaques in arteries. A new, fully synthetic, high-density lipoprotein (HDL)-mimicking MRI contrast agent is developed, which enhances macrophage-rich areas of plaque in a mouse model of atherosclerosis by 94%. Confirmation of the targeting of this nanoparticulate agent is achieved using confocal microscopy by tracking a fluorescent lipid incorporated into the nanoparticle.
Cormode
David P
DP
Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place Box 1234, New York, NY 10029, USA.
Briley-Saebo
Karen C
KC
Mulder
Willem J M
WJ
Aguinaldo
Juan Gilberto S
JG
Barazza
Alessandra
A
Ma
Yanqing
Y
Fisher
Edward A
EA
Fayad
Zahi A
ZA
D000818:Animals; D016632:Apolipoprotein A-I / Q000737:chemistry* / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D050197:Atherosclerosis / Q000175:diagnosis*; D040761:Biomimetic Materials / Q000737:chemistry*; D002460:Cell Line; D003287:Contrast Media / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D051379:Mice; D018345:Mice, Knockout; D046529:Microscopy, Electron, Transmission; D008954:Models, Biological; D008958:Models, Molecular; D015394:Molecular Structure; D008970:Molecular Weight; D010455:Peptides / Q000737:chemistry*
D016632:Apolipoprotein A-I; D003287:Contrast Media; D010455:Peptides