Patient-reported outcomes from a multicenter, randomized, vehicle-controlled clinical study of MAS063DP (Atopiclair) in the management of mild-to-moderate atopic dermatitis in adults.
BACKGROUND
MAS063DP (Atopiclair) is a topical cream approved for symptomatic relief in the treatment of atopic and contact dermatitis.


METHODS
This was a multicenter, randomized, double-blind, vehicle-controlled study in adults with mild-moderate atopic dermatitis. Patients were given MAS063DP or vehicle (2:1) three times per day to areas affected by atopic dermatitis for up to 50 days. A patient global assessment change from baseline was determined at days 8, 22, 36, and 50. Patient total body pruritus (visual analog scale) and patient opinion on treatment acceptability were also assessed.


RESULTS
A total of 218 patients (active: n = 145, vehicle: n = 73) were enrolled. At Day 22, 77% of patients on MAS063DP had a patient global assessment of good improvement or better versus 21% on vehicle (p<0.0001, chi-squared test). Similarly, more patients had improvement in itch over their total body on MAS063DP than on vehicle (p<0.0001).


CONCLUSIONS
MAS063DP treatment results in patient-perceived improvements in mild-moderate atopic dermatitis.
Abramovits
William
W
Department of Dermatology, Baylor University Medical Center and University of Texas Southwestern School of Medicine, Dallas, TX, USA. DrA@DermCenter.us
Hebert
Adelaide A
AA
Boguniewicz
Mark
M
Kempers
Steven E
SE
Tschen
Eduardo
E
Jarratt
Michael T
MT
Lucky
Anne W
AW
Cornelison
Raymond L
RL
Swinyer
Leonard J
LJ
Jones
Terry M
TM
D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000473:pathology; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006034:Glycyrrhetinic Acid / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D010936:Plant Extracts / Q000008:administration & dosage*; D012720:Severity of Illness Index; D013781:Texas; D016896:Treatment Outcome
D003879:Dermatologic Agents; D004041:Dietary Fats; C530270:MAS063DP; D009824:Ointments; D010936:Plant Extracts; D006034:Glycyrrhetinic Acid