title: Gender-related difference in left ventricular diastolic elastance during exercise in patients with diabetes mellitus.
abstract: BACKGROUND
  Because the ratio of mitral inflow and annular velocity to stroke volume has been reported as an index of diastolic elastance (Ed), the hypothesis tested in the present study was that Ed during exercise would be more abnormal in female than in male patients with type 2 diabetes.
  
  
  RESULTS
  Ed was measured at rest and during graded supine bicycle exercise (25W, 3-min increments) in 53 patients (27 males, mean age 53+/-14 years) with type 2 diabetes and 53 age- and gender-matched controls. The patients with diabetes were divided into 2 groups by gender. Ed was not significantly different at rest between men and women, but was significantly higher during exercise in women than in men (25 W, 0.15+/-0.04 vs 0.20+/-0.07, p=0.009; 50 W, 0.16+/-0.05 vs 0.21+/-0.08, p=0.0175).
  
  
  CONCLUSIONS
  Left ventricular (LV) diastolic elastance is abnormal during exercise, but not at rest, in patients with diabetes without overt heart disease. Female gender was associated with increased LV stiffness during exercise among patients with type 2 diabetes.
authors: Division of Cardiology, Yonsei University College of Medicine, Seoul, Republic of Korea. jwha@yuhs.ac
authors: Jong-Won
authors: JW
authors: Ha
authors: Hyun-Chul
authors: HC
authors: Lee
authors: Sungha
authors: S
authors: Park
authors: Eui-Young
authors: EY
authors: Choi
authors: Hye-Sun
authors: HS
authors: Seo
authors: Chi-Young
authors: CY
authors: Shim
authors: Jin-Mi
authors: JM
authors: Kim
authors: Jeong-Ah
authors: JA
authors: Ahn
authors: Se-Wha
authors: SW
authors: Lee
authors: Se-Joong
authors: SJ
authors: Rim
authors: Jae K
authors: JK
authors: Oh
authors: Namsik
authors: N
authors: Chung
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004548:Elasticity; D015444:Exercise; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000503:physiopathology*; D012727:Sex Characteristics; D012737:Sex Factors; D013318:Stroke Volume