title: [Effect of several penetration enharcers on transdermal permeation and skin accumulation of artemether].
abstract: OBJECTIVE
  To investigate penetration characteristics of artemether and the effect of different permeation enhancer on transdermal permeation of artemether through rat skin.
  
  
  METHODS
  The permeation experiments were performed using rat skin on modified Franz diffusion cells in vitro. The concentrations of artemether in receptor compartment at specified time points were determined by HPLC.
  
  
  RESULTS
  The permeating ratio through human skin of artemether solution was Js (2.78 +/- 0.78) microg x cm(-2) x h(-1), the quantity of drug penetrated through and accumulated in the skin by the end of the experiment were (69.07 +/- 3.01) microg x cm(-2), (58.93 +/- 3.56) microg x cm(-2) respectively. Four different permeation enhancers can improve the transdermal permeation of artemether.
  
  
  CONCLUSIONS
  Artemether have the potential to be developed to new transdermal preparation.
authors: West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors: Jun-Yao
authors: JY
authors: He
authors: Shi-Xiang
authors: SX
authors: Hou
authors: Zheng
authors: Z
authors: Cai
authors: Dan-Dan
authors: DD
authors: Guo
authors: Rong-Li
authors: RL
authors: Zhao
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000737:chemistry*; D000818:Animals; D000077549:Artemether; D037621:Artemisinins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D008297:Male; D010539:Permeability / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects / Q000378:metabolism*
chemical_list: D000277:Adjuvants, Pharmaceutic; D037621:Artemisinins; D004365:Drugs, Chinese Herbal; D000077549:Artemether