title: Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy.
abstract: The biomedical applications of carbon nanotubes (CNTs) have attracted deep interest in recent years. Antitumor immunotherapy has the potential to improve the prognosis of cancer treatment but the efficacy of current immunotherapy generally needs further improvement. Multi-walled CNTs conjugated to tumor lysate protein are investigated as to whether they would enhance the efficacy of an immunotherapy employing a tumor-cell vaccine in a mouse model bearing the H22 liver cancer. The tumor cure rate is found to be markedly improved by CNTs conjugated to tumor lysate protein. The cellular antitumor immune reaction is also enhanced. Moreover, the observed antitumor immune response is relatively specific against the tumor intended for treatment. These findings suggest that CNTs may have a prospective role in the development of new antitumor immunotherapies.
authors: Department of Biomedical Engineering Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College 5 Dong Dan San Tiao, Beijing 100005, PR China.
authors: Jie
authors: J
authors: Meng
authors: Jie
authors: J
authors: Meng
authors: Jinhong
authors: J
authors: Duan
authors: Hua
authors: H
authors: Kong
authors: Li
authors: L
authors: Li
authors: Chen
authors: C
authors: Wang
authors: Sishen
authors: S
authors: Xie
authors: Shuchang
authors: S
authors: Chen
authors: Ning
authors: N
authors: Gu
authors: Haiyan
authors: H
authors: Xu
authors: Xian-Da
authors: XD
authors: Yang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D007167:Immunotherapy; D051379:Mice; D008854:Microscopy, Electron; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy*
chemical_list: D037742:Nanotubes, Carbon