title: Huge thymoma: role of preoperative WHO histological classification.
abstract: A 57-year-old woman was admitted to our hospital with complaints of recent onset of dyspnea on exertion. A chest computed tomography revealed a large mediastinal mass which extrinsically compressed the heart and mediastinal structures, occupying one half of the hemithorax. A needle biopsy was performed to find a thymoma with type AB according to the WHO classification. Based on the radiological and histological finding a surgery for the tumor was achieved by exploratory VATS thoracotomy followed by thymectomy through a median sternotomy with tumor extirpation of 910 g in weight. A definite diagnosis of thymoma (Masaoka I) without capsular invasion was obtained from the pathologic findings, including positive immunohistochemical staining for CD1a and cytokeratin.
authors: Department of General Thoracic Surgery, Osaka General Medical Center, Osaka, Japan. stakeda@gh.pref.osaka.jp
authors: Shin-ichi
authors: S
authors: Takeda
authors: Masaru
authors: M
authors: Koma
authors: Hajime
authors: H
authors: Maeda
mesh_terms: D018949:Antigens, CD1 / Q000032:analysis; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012128:Respiratory Distress Syndrome / Q000209:etiology; D013249:Sternum / Q000601:surgery; D009626:Terminology as Topic; D020775:Thoracic Surgery, Video-Assisted; D013908:Thoracotomy; D013934:Thymectomy; D013945:Thymoma / Q000145:classification / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013953:Thymus Neoplasms / Q000145:classification / Q000150:complications / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014944:World Health Organization
chemical_list: D018949:Antigens, CD1; C419393:CD1a antigen; D007633:Keratins