title: Antiinfective properties of human milk.
abstract: The unfavorable effects of neonatal immunodeficiency are limited by some naturally occurring compensatory mechanisms, such as the introduction of protective and immunological components of human milk in the infant. Breast-feeding maintains the maternal-fetal immunological link after birth, may favor the transmission of immunocompetence from the mother to her infant, and is considered an important contributory factor to the neonatal immune defense system during a delicate and crucial period for immune development. Several studies have reported that breast-feeding, because of the antimicrobial activity against several viruses, bacteria, and protozoa, may reduce the incidence of infection in infants. The protection from infections may be ensured either passively by factors with antiinfective, hormonal, enzymatic, trophic, and bioactive activity present in breast milk, or through a modulator effect on the neonatal immune system exerted by cells, cytokines, and other immune agents in human milk.
authors: Department of Neonatology and Neonatal Intensive Care, Spedali Civili, 25123 Brescia, Italy. gaechirico@alice.it
authors: Gaetano
authors: G
authors: Chirico
authors: Roberto
authors: R
authors: Marzollo
authors: Sheila
authors: S
authors: Cortinovis
authors: Chiara
authors: C
authors: Fonte
authors: Antonella
authors: A
authors: Gasparoni
mesh_terms: D001942:Breast Feeding; D003141:Communicable Diseases / Q000276:immunology*; D005260:Female; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007112:Immunity, Maternally-Acquired / Q000276:immunology*; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D008895:Milk, Human / Q000276:immunology* / Q000382:microbiology / Q000821:virology