title: Percutaneous pelvic perfusion with extracorporeal chemofiltration for advanced uterine cervical carcinoma.
abstract: This review was focused on a new intra-arterial infusion system with an extracorporeal chemofiltration circuit. After inferior vena cava isolation was percutaneously achieved by balloon catheter technique, cisplatin (140-240 mg/m(2)) was administered by intrauterine arterial infusion, with inferior and superior gluteal arterial embolization. The platinum-containing blood was pumped through an extracorporeal charcoal chemofiltration circuit. The percutaneous pelvic perfusion with extracorporeal chemofiltration (PPPEC) achieved a super high-dose cisplatin perfusion with the minimal adverse effects, allowing cisplatin dose escalation with further augmented tumor response. The results obtained in 23 patients who received neoadjuvant chemotherapy under PPPEC demonstrate that PPPEC has a better therapeutic advantage because of prompt tumor down-staging of locally advanced uterine cervical carcinoma with minimal adverse effects.
authors: Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kusunoki-cho, 7-Chome, Chuo-ku, Kobe, Japan. maruo@kobe-u.ac.jp
authors: Takeshi
authors: T
authors: Maruo
authors: Satoru
authors: S
authors: Motoyama
authors: Shinya
authors: S
authors: Hamana
authors: Shigeki
authors: S
authors: Yoshida
authors: Noriyuki
authors: N
authors: Ohara
authors: Mineo
authors: M
authors: Yamasaki
authors: Yonson
authors: Y
authors: Ku
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000009:adverse effects / Q000379:methods*; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000188:drug therapy* / Q000401:mortality; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000401:mortality
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin