[Structure and function of lipopolysaccharide lipid A in bacteria--a review].
Lipid A, the hydrophobic group of lipopolysaccharide, covers the surface of most Gram-negative bacteria. Lipopolysaccharide, known as endotoxin, can cause fatal disease like sepsis syndrome. Recent studies have shown that it is only the lipid A part of lipopolysaccharide that has the function of endotoxin. After entering the human body, lipid A on the surface of bacteria can stimulate the Toll-like-receptor 4 on the surface of host cells, cause a series of reaction, and produce different cytokines. Here we have discussed the structure, biosynthesis and pathogenesis of lipid A. The application of lipid A in vaccine development was proposed.
Li
Yanyan
Y
State Key Laboratory of Food Science and Technology, Key Laboratory of Industrial Biotechnology of the Ministry of Education, Jiangnan University, Wuxi, 214122. liyanyan1123@163.com
Shi
Feng
F
Li
Ye
Y
Wang
Xiaoyuan
X
D001419:Bacteria / Q000276:immunology / Q000378:metabolism*; D001428:Bacterial Vaccines; D001692:Biological Transport; D006801:Humans; D008070:Lipopolysaccharides / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction; D013045:Species Specificity
D001428:Bacterial Vaccines; D008070:Lipopolysaccharides; C082161:lipopolysaccharide A