Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy.
The biomedical applications of carbon nanotubes (CNTs) have attracted deep interest in recent years. Antitumor immunotherapy has the potential to improve the prognosis of cancer treatment but the efficacy of current immunotherapy generally needs further improvement. Multi-walled CNTs conjugated to tumor lysate protein are investigated as to whether they would enhance the efficacy of an immunotherapy employing a tumor-cell vaccine in a mouse model bearing the H22 liver cancer. The tumor cure rate is found to be markedly improved by CNTs conjugated to tumor lysate protein. The cellular antitumor immune reaction is also enhanced. Moreover, the observed antitumor immune response is relatively specific against the tumor intended for treatment. These findings suggest that CNTs may have a prospective role in the development of new antitumor immunotherapies.
Meng
Jie
J
Department of Biomedical Engineering Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College 5 Dong Dan San Tiao, Beijing 100005, PR China.
Meng
Jie
J
Duan
Jinhong
J
Kong
Hua
H
Li
Li
L
Wang
Chen
C
Xie
Sishen
S
Chen
Shuchang
S
Gu
Ning
N
Xu
Haiyan
H
Yang
Xian-Da
XD
D000818:Animals; D045744:Cell Line, Tumor; D007167:Immunotherapy; D051379:Mice; D008854:Microscopy, Electron; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy*
D037742:Nanotubes, Carbon