Effect of 17beta-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats.
The present study evaluated 17beta-estradiol (17betaE(2)) (2.5 mg/kg sc) effects on bilateral OBX-induced behavioral changes and oxidative stress. OBX in male Wistar rats produced an increase in lipid peroxidation products and a decline in reduced glutathione (GSH) content and glutathione peroxidase (GSH-Px) activity, together with an increase in caspase-3 activity. Additionally, OBX triggered changes of behavior such as an enhancement of immobility time in the forced swim test and hyperactivity in the open field test. These changes were reversed by treatment with 17betaE(2) (14 days). Our results reveled that 17betaE(2) has a protective effect against oxidative stress, cell damage and behavioral changes induced by OBX, and present antidepressant and antianxiety properties.
Tasset
Inmaculada
I
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba Córdoba, Spain.
Peña
José
J
Jimena
Ignacio
I
Feijóo
Montserrat
M
Del Carmen Muñoz
María
M
Montilla
Pedro
P
Túnez
Isaac
I