[Occurrence and influencing factors of paranasal sinusitis in nasopharyngeal carcinoma patients after radiotherapy].
OBJECTIVE
Radiation usually results in paranasal sinusitis in nasopharyngeal carcinoma (NPC) patients, which influences patients' quality of life. This study was to explore the occurrence and influencing factors of paranasal sinusitis in NPC patients before and after radiotherapy.


METHODS
Clinical data of 381 NPC patients, treated in Cancer Center of Sun Yat-sen University from Jan. 1998 to Jul. 2000, were reviewed. CT images before and after radiotherapy were compared. The occurrence and influencing factors of paranasal sinusitis were analyzed.


RESULTS
Of the 381 NPC patients, 176 (46.2%) suffered from paranasal sinusitis before radiotherapy. Among the 205 NPC patients without paranasal sinusitis before radiotherapy, 103 (50.2%) developed paranasal sinusitis after radiotherapy; the occurrence rates of paranasal sinusitis at 1 month, 3 months, 6 months, and 1 year after radiotherapy were 21.0%, 33.7%, 41.5% and 29.3%, respectively (Chi(2)=20.92, P<0.001). Logistic analysis showed that T stage was related to the occurrence rate of paranasal sinusitis.


CONCLUSIONS
The incidence of paranasal sinusitis in NPC patients after radiotherapy is high and related to T stage.
Yuan
Tai-Ze
TZ
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, P. R. China.
Guo
Xiang
X
Zheng
Lie
L
Cao
Su-Mei
SM
Li
Ning-Wei
NW
Xiang
Yan-Qun
YQ
D000293:Adolescent; D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects; D003037:Cobalt Radioisotopes / Q000009:adverse effects; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D009367:Neoplasm Staging; D010315:Particle Accelerators; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000009:adverse effects*; D012852:Sinusitis / Q000209:etiology*; D055815:Young Adult
D003037:Cobalt Radioisotopes