title: Sensory neural hearing loss in beta-thalassemia major patients treated with deferoxamine.
abstract: This study evaluated the incidence of sensory neural hearing loss (SNHL) in beta-thalassemia major patients treated with deferoxamine in Mofid Children's Hospital. Based on the patients' file review, this descriptive and cross-sectional study was performed in all thalassemia patients older than 5 years old who were treated with regular blood transfusion and deferoxamine pump injection during the year 2006. The first visit with the otolaryngologist was performed in all patients to demarcate the presence of cerumen, otitis, and congenital abnormalities of ears. Then pure tone audiometery in frequency ranges of 250-8000 Hz was performed. Data statistical analysis was done by Mann-Whitney, chi square, and Fisher tests. There were 67 patients over 5 years old in our study. Five patients (7.4%), including 2 boys and 3 girls, in the age range of 7-24 years (mean:17.8 +/- 6.6 years) had SNHL. Their hearing loss was bilateral and in the frequency range of 2000-4000 Hz, with a mean of 3200 +/- 836.66 Hz. There were no significant differences between SNHL and non-SNHL patients in age, sex, serum ferritin level, age of the first transfusion, starting age of deferoxamine infusion, or duration and dosage of deferoxamine therapy. It seems that SNHL is not directly related to the serum ferritin level or deferoxamine dosage and other factors, including genetic or constitutional characteristics, may be also related. On the other hand, this complication may occur with doses lower than 50 mg/kg/day of deferoxamine, so no dosage can be considered safe for this drug. Despite the results of this study, hearing evaluation of beta-thalassemia major patients by audiometry is recommended because of the importance of this complication and the consequent disabilities.
authors: Department of Hematology-Oncology, Mofid Children's Hospital, Tehran, Iran. shamsianb@yahoo.com
authors: Bibi Shahin
authors: BS
authors: Shamsian
authors: Ali
authors: A
authors: Aminasnafi
authors: Habiballah
authors: H
authors: Moghadassian
authors: Latif
authors: L
authors: Gachkar
authors: M Taghi
authors: MT
authors: Arzanian
authors: Samin
authors: S
authors: Alavi
authors: Hossein
authors: H
authors: Esfehani
authors: Farnoush
authors: F
authors: Garallahi
authors: Reyhaneh
authors: R
authors: Amini
mesh_terms: D000293:Adolescent; D001301:Audiometry, Pure-Tone; D003430:Cross-Sectional Studies; D003676:Deferoxamine / Q000008:administration & dosage*; D005260:Female; D005293:Ferritins / Q000097:blood; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D008297:Male; D017262:Siderophores / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult; D017086:beta-Thalassemia / Q000150:complications / Q000188:drug therapy*
chemical_list: D017262:Siderophores; D005293:Ferritins; D003676:Deferoxamine