title: Using expression profiles of Caenorhabditis elegans neurons to identify genes that mediate synaptic connectivity.
abstract: Synaptic wiring of neurons in Caenorhabditis elegans is largely invariable between animals. It has been suggested that this feature stems from genetically encoded molecular markers that guide the neurons in the final stage of synaptic formation. Identifying these markers and unraveling the logic by which they direct synapse formation is a key challenge. Here, we address this task by constructing a probabilistic model that attempts to explain the neuronal connectivity diagram of C. elegans as a function of the expression patterns of its neurons. By only considering neuron pairs that are known to be connected by chemical or electrical synapses, we focus on the final stage of synapse formation, in which neurons identify their designated partners. Our results show that for many neurons the neuronal expression map of C. elegans can be used to accurately predict the subset of adjacent neurons that will be chosen as its postsynaptic partners. Notably, these predictions can be achieved using the expression patterns of only a small number of specific genes that interact in a combinatorial fashion.
authors: Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
authors: Leehod
authors: L
authors: Baruch
authors: Shalev
authors: S
authors: Itzkovitz
authors: Michal
authors: M
authors: Golan-Mashiach
authors: Ehud
authors: E
authors: Shapiro
authors: Eran
authors: E
authors: Segal
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology*; D020869:Gene Expression Profiling; D009474:Neurons / Q000378:metabolism*; D009435:Synaptic Transmission