title: Memory impairment correlates with increased S100B serum concentrations in patients with chronic schizophrenia.
abstract: Astrocyte activation indicated by increased S100B is considered a potential pathogenic factor for schizophrenia. To investigate the relationship between astrocyte activation and cognitive performance, S100B serum concentration, memory performance, and psychopathology were assessed in 40 first-episode and 35 chronic schizophrenia patients upon admission and after four weeks of treatment. Chronic schizophrenia patients with high S100B were impaired concerning verbal memory performance (AVLT, Auditory Verbal Learning Test) compared to chronic and first-episode patients with low S100B levels. The findings support the hypothesis that astrocyte activation might contribute to the development of cognitive dysfunction in schizophrenia.
authors: University Medical Faculty, Department of Psychiatry, 48149 Münster, Germany. Anya.Pedersen@ukmuenster.de
authors: Anya
authors: A
authors: Pedersen
authors: Markus
authors: M
authors: Diedrich
authors: Florian
authors: F
authors: Kaestner
authors: Katja
authors: K
authors: Koelkebeck
authors: Patricia
authors: P
authors: Ohrmann
authors: Gerald
authors: G
authors: Ponath
authors: Frank
authors: F
authors: Kipp
authors: Simone
authors: S
authors: Abel
authors: Ansgar
authors: A
authors: Siegmund
authors: Thomas
authors: T
authors: Suslow
authors: Christof
authors: C
authors: von Eiff
authors: Volker
authors: V
authors: Arolt
authors: Matthias
authors: M
authors: Rothermundt
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000097:blood* / Q000209:etiology*; D009414:Nerve Growth Factors / Q000097:blood*; D009483:Neuropsychological Tests; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D012559:Schizophrenia / Q000097:blood / Q000150:complications*; D014706:Verbal Learning / Q000502:physiology; D055815:Young Adult
chemical_list: D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human