Comparison of two treatment approaches for prostate cancer: intensity-modulated radiation therapy combined with 125I seed-implant brachytherapy or 125I seed-implant brachytherapy alone.
The purpose of the present study was to assess the results of two different treatment approaches for clinically localized prostate cancer: intensity-modulated radiation therapy (IMRT) followed by 125I seed-implant brachytherapy and 125I seed-implant brachytherapy alone. We studied our 30 most recent consecutive patients. The sample population consisted of 15 cases treated with IMRT (50.4 Gy) followed by 125I seed-implant boost (95 Gy), and 15 cases treated with 125I seed implant only (144 Gy). We analyzed established dosimetric indices and various clinical parameters. In addition, we also evaluated and compared the acute urinary morbidities of the two treatment approaches, as assessed by the international prostate symptom score (IPSS). In our series, acute urinary morbidity was slightly increased with IMRT followed by 125I seed-implant brachytherapy as compared with 125I seed-implant brachytherapy alone. In addition, we observed no statistically significant correlation between the IPSS and the maximum or mean urethral dose. The combination of IMRT and seed-implant brachytherapy presents an alternative opportunity to treat clinically localized prostate cancer. The full potential of the procedure needs to be further investigated.
Song
Yulin
Y
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, Dover, New Jersey, U.S.A.
Chan
Maria F
MF
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, Dover, New Jersey, U.S.A.
Burman
Chandra
C
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, Dover, New Jersey, U.S.A.
Cann
Donald
D
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, Dover, New Jersey, U.S.A.
D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D003131:Combined Modality Therapy / Q000379:methods; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D011877:Radionuclide Imaging; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*
D007457:Iodine Radioisotopes