title: A role for mannose-binding lectin, a component of the innate immune system in pre-eclampsia.
abstract: OBJECTIVE
  Mannose-binding lectin (MBL) is a pattern-recognition receptor that activates complement and modulates inflammation. Homozygosity for the most common allele of the MBL2 gene that is associated with high MBL serum concentrations is more prevalent among patients with pre-eclampsia. The objective of this study was to determine maternal plasma MBL concentrations in normal pregnant women and patients with pre-eclampsia.
  
  
  METHODS
  This cross-sectional study included normal pregnant women (n = 187) and patients with pre-eclampsia (n = 99). Maternal plasma MBL concentrations were determined by ELISA.
  
  
  RESULTS
  Women with pre-eclampsia had a higher median maternal plasma MBL concentration than normal pregnant women. MBL concentration distribution curves were three-modal, the subintervals in normal pregnancy were low (< 143.7), intermediate (143.7-1898.9) and high (> 1898.9 ng/mL). The proportion of normal pregnant women was larger in the low subinterval, while the proportion of patients with preeclampsia was larger in the high subinterval (P = 0.02). Normal pregnant women in the high subinterval had a larger rate of placental underperfusion than those in the low and intermediate subintervals (P = 0.02).
  
  
  CONCLUSIONS
  The median maternal plasma MBL concentration is elevated in patients with pre-eclampsia and a larger proportion of these patients are in the high subinterval than normal pregnant women, suggesting that this component of the innate immune system is involved in the mechanisms of disease in pre-eclampsia.
authors: Perinatology Research Branch, NICHD/NIH/DHHS, Wayne State University/Hutzel Women's Hospital, 3990 John R, Box 4, Detroit, MI 48201, USA. nthan@med.wayne.edu
authors: Nandor Gabor
authors: NG
authors: Than
authors: Roberto
authors: R
authors: Romero
authors: Offer
authors: O
authors: Erez
authors: Juan Pedro
authors: JP
authors: Kusanovic
authors: Adi L
authors: AL
authors: Tarca
authors: Samuel S
authors: SS
authors: Edwin
authors: Jung-Sun
authors: JS
authors: Kim
authors: Sonia S
authors: SS
authors: Hassan
authors: Jimmy
authors: J
authors: Espinoza
authors: Pooja
authors: P
authors: Mittal
authors: Shali
authors: S
authors: Mazaki-Tovi
authors: Lara
authors: L
authors: Friel
authors: Francesca
authors: F
authors: Gotsch
authors: Edi
authors: E
authors: Vaisbuch
authors: Natalia
authors: N
authors: Camacho
authors: Zoltan
authors: Z
authors: Papp
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate; D037601:Mannose-Binding Lectin / Q000097:blood / Q000235:genetics / Q000276:immunology*; D011225:Pre-Eclampsia / Q000097:blood / Q000235:genetics / Q000276:immunology*; D011247:Pregnancy
chemical_list: C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin