title: Dry coating of soft gelatin capsules with HPMCAS.
abstract: Dry coating is an innovative powder-layering technique that enables the formation of coatings on solid dosage forms with no need for using water or organic solvents. This technique envisages the distribution of polymer powder blends onto substrate cores and the concurrent or alternate nebulization of liquid plasticizers. In this work, a dry coating process based on hydroxypropyl methylcellulose acetate succinate (HPMCAS) was set up in a rotary fluid bed equipment to prepare enteric-coated soft gelatin capsules. Promising results were obtained in terms of process feasibility and product characteristics, thus suggesting the possibility of advantageous applications for the investigated technique when dealing with gelatin capsule substrates.
authors: Istituto di Chimica Farmaceutica e Tossicologica "P. Pratesi", Universita degli Studi di Milano, Milan, Italy. matteo.cerea@unimi.it
authors: Matteo
authors: M
authors: Cerea
authors: Anastasia
authors: A
authors: Foppoli
authors: Alessandra
authors: A
authors: Maroni
authors: Luca
authors: L
authors: Palugan
authors: Lucia
authors: L
authors: Zema
authors: Maria Edvige
authors: ME
authors: Sangalli
mesh_terms: D002214:Capsules; D005079:Excipients / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D005780:Gelatin / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D011208:Powders; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D002214:Capsules; D005079:Excipients; D011208:Powders; C048331:hydroxypropylmethylcellulose acetate succinate; D005780:Gelatin; D008747:Methylcellulose