Evaluation of protective effect of bee pollen against propoxur toxicity in rat.
In this study, 28 Wistar female rats (200-250g) were used and divided into four equal groups. Group 1 was allocated as the control group. Groups 2-4 were administered 100mg/kg/bw/day bee pollen, 20mg/kg/bw/day propoxur, and 100mg/kg/bw/day bee pollen plus 20mg/kg/bw/day propoxur by gavage for 14 days, respectively. At the end of the 14th day, blood and tissues (the liver, kidney, brain, and heart) were collected from all animals. Oxidative stress markers (MDA, CAT, SOD, GSH-Px) and some other biochemical parameters (total protein, albumin, glucose, cholesterol, triglyceride, BUN, creatinine, uric acid, magnesium, sodium, potassium, chloride, total bilirubin, GGT, LDH, AST, ALT, and ALP) were analyzed. According to the data obtained, propoxur was determined to lead to negative changes in most of the biochemical parameters investigated and the administration of bee pollen was determined to alleviate these effects.
Eraslan
Gökhan
G
Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, University of Erciyes, Kayseri, Turkey.
Kanbur
Murat
M
Silici
Sibel
S
Cem Liman
Bilal
B
Altinordulu
Sule
S
Soyer Sarica
Zeynep
Z
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001516:Bees / Q000502:physiology; D015415:Biomarkers / Q000378:metabolism; D001774:Blood Chemical Analysis; D004336:Drug Antagonism; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010088:Oxidoreductases / Q000378:metabolism; D011429:Propolis / Q000494:pharmacology*; D001074:Propoxur / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D000890:Anti-Infective Agents; D015415:Biomarkers; D007306:Insecticides; D008315:Malondialdehyde; D011429:Propolis; D001074:Propoxur; D010088:Oxidoreductases