Occurrence of trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a patient with B-cell chronic lymphocytic leukemia.
Trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) were found in a 59-year-old man with B-cell chronic lymphocytic leukemia (CLL). While trisomy 12 is one of the most common cytogenetic abnormalities in chronic lymphocytic leukemia, the t(14;18) rearrangement has a strong association with follicular lymphoma and the t(8;14) is associated with T-cell neoplasia. Occurrence of these three abnormalities in CLL are rare, and the significance of this finding is unclear. Further studies of similar cases may shed additional insight into this finding.
Lau
Lai-Ching
LC
Department of Pathology, Singapore General Hospital, Outram Road, Singapore. lau.lai.ching@sgh.com.sg
Lim
Ping
P
Lim
Yik-Chen
YC
Teng
Li-Min
LM
Lim
Tse-Hui
TH
Lim
Lay-Cheng
LC
Tan
Soo-Yong
SY
Lim
Soon-Tiong
ST
Sanger
Warren G
WG
Tien
Sim-Leng
SL
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005434:Flow Cytometry; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic; D014314:Trisomy