The effect of Interceed for reducing adhesion as a middle ear packing agent: an experimental study.
OBJECTIVE
Interceed (oxidized regenerated cellulose) has been used to prevent postoperative abdominal adhesion. However, the efficacy and safety of using Interceed in middle ear surgery have not been thoroughly studied.


METHODS
The animals were divided into two groups: the Interceed group and the Gelfoam (Gelatin sponge) group. In every group, the study was performed on five guinea pigs (ten ears). Under the aseptic condition, the middle ear mucosa was abraded using a pick through a myringotomy incision. Interceed and Gelfoam were then packed into the guinea pigs' middle ear cavities. The auditory brainstem responses (ABRs) were assessed preoperatively and at 3 weeks after the operation with the animals under general anesthesia. Histopathologic study was performed 3 weeks after the operation.


RESULTS
The ABR results on postoperative week 3 showed no statistically significant difference for myringotomy and postpacking. The fibrosis, middle ear mucosa thickening and adhesion formation appeared to be less in the Interceed group compared with the Gelfoam group. Any foreign body reaction was not observed in the Interceed group.


CONCLUSIONS
Our results show that Interceed is nonototoxic and biocompatible with the guinea pig's middle ear cavity. Therefore, these results suggest that Interceed could be used safely in the middle ear as a middle ear packing agent during otosurgery.
Jang
Chul Ho
CH
Department of Otolaryngology, Chonnam National University Medical School, South Korea. chulsavio@hanmail.net
Park
Haekyun
H
Cho
Yong Bum
YB
Choi
Chel Hee
CH
D000818:Animals; D002483:Cellulose, Oxidized / Q000627:therapeutic use*; D004432:Ear, Middle / Q000503:physiopathology / Q000601:surgery*; D016057:Evoked Potentials, Auditory, Brain Stem; D005781:Gelatin Sponge, Absorbable / Q000627:therapeutic use; D006168:Guinea Pigs; D006314:Hearing Loss, Conductive / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D006490:Hemostatics / Q000627:therapeutic use; D008297:Male; D009092:Mucous Membrane / Q000601:surgery; D013506:Otologic Surgical Procedures / Q000009:adverse effects* / Q000379:methods*; D000267:Tissue Adhesions / Q000209:etiology* / Q000517:prevention & control*; D014945:Wound Healing
D002483:Cellulose, Oxidized; D006490:Hemostatics; C060002:INTERCEED