Silencing HIV-1 In Vivo.
RNA interference holds great promise for antiviral therapy, but delivering effective quantities of small interfering RNAs (siRNAs) into the right target cells in vivo represents a major challenge. Kumar et al. (2008) now report a technique to target siRNAs specifically to T cells to suppress viral infection in a humanized mouse model of HIV/AIDS.
Kirchhoff
Frank
F
Institute of Virology, University of Ulm, 89081 Ulm, Germany. frank.kirchhoff@uniklinik-ulm.de
D000818:Animals; D015658:HIV Infections / Q000235:genetics* / Q000628:therapy*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism*
D034741:RNA, Small Interfering