Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells.
What is the relationship between stem cell aging and organismal aging? Does stem cell aging cause organismal aging or vice versa? Will stem cell aging aggravate age-related diseases? And what is stem cell aging? As suggested herein, hyperstimulation of signal transduction pathways can render cells compensatorily irresponsive. And the hallmark of stem cell aging is poor responsiveness to activating stimuli. On the basis of the hypothesis that insensitivity to stimuli is in part due to hyperactivation of the target of rapamycin (TOR), this article suggests a means of pharmacologic rejuvenation of stem cells and wound-healing cells.
Blagosklonny
Mikhail V
MV
Cancer Center, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA. blagosklonny@oncotarget.com
D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D016922:Cellular Senescence / Q000187:drug effects / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology; D025461:Feedback, Physiological / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D011494:Protein Kinases / Q000502:physiology*; D012060:Rejuvenation / Q000502:physiology*; D020123:Sirolimus / Q000494:pharmacology / Q000627:therapeutic use*; D013234:Stem Cells / Q000187:drug effects / Q000502:physiology*; D058570:TOR Serine-Threonine Kinases; D014945:Wound Healing / Q000502:physiology
D011494:Protein Kinases; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus