How chemokines invite leukocytes to dance.
A prominent activity of the chemokine system is the regulation of leukocyte trafficking. Here we summarize recent findings on the initial steps in chemokine receptor-induced signal transduction in leukocytes. In particular, we discuss the potential influences of the formation of oligomers of ligand and receptor and of coupling between chemokine signals and regulators of the cytoskeleton, such as small GTPases.
Thelen
Marcus
M
Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland. marcus.thelen@irb.unisi.ch
Stein
Jens V
JV
D000818:Animals; D018925:Chemokines / Q000276:immunology* / Q000378:metabolism*; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D008213:Lymphocyte Activation; D019707:Receptors, Chemokine / Q000378:metabolism; D015398:Signal Transduction
D018925:Chemokines; D019707:Receptors, Chemokine; D020558:GTP Phosphohydrolases