title: Older Americans' risk-benefit preferences for modifying the course of Alzheimer disease.
abstract: Alzheimer disease (AD) is a progressive, ultimately fatal neurodegenerative illness affecting millions of patients, families, and caregivers. Effective disease-modifying therapies for AD are desperately needed, but none currently exist on the market. Thus, accelerating the discovery, development, and approval of new disease-modifying drugs for AD is a high priority for individuals, physicians, and medical decision makers. Potentially disease-modifying drugs likely will have significant therapeutic benefits but also may have treatment-related risks. We quantified older Americans' treatment-related risk tolerance by eliciting their willingness to accept the risk of treatment-related death or permanent severe disability in exchange for modifying the course of AD. A stated-choice survey instrument was administered to 2146 American residents 60 years of age and older. On average, subjects were willing to accept a 1-year risk of treatment-related death or permanent severe disability from stroke of over 30% for a treatment that prevents AD from progressing beyond the mild stage. Thus, most people in this age cohort are willing to accept considerable risks in return for disease-modifying benefits of new AD drugs. These results are consistent with other studies indicating that individuals view AD as a serious, life threatening illness that imposes heavy burdens on both patients and caregivers.
authors: RTI International, RTI HealthSolutions, 3040 Cornwallis Road, PO Box 12194, Research Triangle Park, NC 27709-2194, USA. abhauber@rti.org
authors: A Brett
authors: AB
authors: Hauber
authors: F Reed
authors: FR
authors: Johnson
authors: Howard
authors: H
authors: Fillit
authors: Ateesha F
authors: AF
authors: Mohamed
authors: Christopher
authors: C
authors: Leibman
authors: H Michael
authors: HM
authors: Arrighi
authors: Michael
authors: M
authors: Grundman
authors: Raymond J
authors: RJ
authors: Townsend
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D003625:Data Collection; D006801:Humans; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000009:adverse effects*; D018570:Risk Assessment; D012309:Risk-Taking; D014481:United States
chemical_list: D018696:Neuroprotective Agents