title: Nationwide surveillance of antimicrobial resistance among Enterobacteriaceae in intensive care units in Taiwan.
abstract: To determine the antimicrobial resistance profiles among clinical isolates of Enterobacteriaceae in Taiwanese intensive care units (ICUs), a national surveillance of antibiotic resistance among important Enterobacteriaceae was conducted from September 2005 through November 2005 at the ICUs of ten major teaching hospitals in Taiwan. A total of 574 Enterobacteriaceae isolates recovered from various clinical samples of our ICU patients were submitted for in vitro test. Minimum inhibitory concentrations (MICs) of these isolates to 18 antimicrobial agents were determined by the broth microdilution method. The prevalences of Enterobacteriaceae isolates with phenotypic extended-spectrum beta-lactamase (ESBL) production were 26% in Klebsiella pneumoniae, 16% in Serratia marcescens, 14% in Escherichia coli, and 13% in Proteus mirabilis, in which a significantly rising prevalence of ESBL production among K. pneumoniae was noted (p = 0.002) when compared with a previous Taiwanese survey in 2000. Heterogeneous resistance to various fluoroquinolones was found among our Enterobacteriaceae isolates, except for Enterobacter cloacae. Emergence of ertapenem-resistant isolates of E. coli, K. pneumoniae, E. cloacae, and S. marcescens was noted. Gradually increasing rates of drug-resistant Enterobacteriaceae were noted in Taiwanese ICUs. Periodic surveillance of the evolutionary trend of antimicrobial resistance among ICU isolates is crucial for starting appropriately empirical antimicrobial therapy in the future.
authors: Department of Intensive Care Units, Min-Sheng General Hospital, Taoyuan County, Taiwan.
authors: S-S
authors: SS
authors: Jean
authors: P-R
authors: PR
authors: Hsueh
authors: W-S
authors: WS
authors: Lee
authors: H-T
authors: HT
authors: Chang
authors: M-Y
authors: MY
authors: Chou
authors: I-S
authors: IS
authors: Chen
authors: J-H
authors: JH
authors: Wang
authors: C-F
authors: CF
authors: Lin
authors: J-M
authors: JM
authors: Shyr
authors: W-C
authors: WC
authors: Ko
authors: J-J
authors: JJ
authors: Wu
authors: Y-C
authors: YC
authors: Liu
authors: W-K
authors: WK
authors: Huang
authors: L-J
authors: LJ
authors: Teng
authors: C-Y
authors: CY
authors: Liu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D007362:Intensive Care Units; D008826:Microbial Sensitivity Tests; D013624:Taiwan
chemical_list: D000900:Anti-Bacterial Agents