Histopathologic changes in guinea pig mastoid mucosa after topical mitomycin C application followed by mastoidectomy.
OBJECTIVE
This study was performed to investigate the histopathologic changes observed in mastoid cavity of guinea pigs after the application of mitomycin C after mastoidectomy.


METHODS
The study was performed on 50 guinea pigs. Unilateral (right ear) mastoidectomy was performed on all guinea pigs. Twenty-five guinea pigs were separated as study group and the remaining were separated as control group. A mitomycin C-soaked sponge was placed in the mastoid cavities of the study group and a dry sponge was placed in those of the control group. Their mastoid cavities were examined histopathologically for absorbable sponge waste, abscess formation, fibrosis, vascularization, polymorphonuclear leukocyte infiltration, edema, lymphoplasmacytic inflammatory infiltration, and granulation tissue.


RESULTS
Absorbable sponge waste, abscess formation, fibrosis, vascularization, edema, and lymphoplasmacytic inflammatory infiltration were not significantly different between the groups. However, polymorphonuclear leukocyte infiltration and granulation tissue were statistically different between the groups.


CONCLUSIONS
Mitomycin C can be used after mastoidectomy to decrease the granulation tissue formation in ear discharges and to prevent the discharge.
Ozturk
Levent
L
Department of Otorhinolaryngology, Kahramanmaraş Government Hospital, Kahramanmaraş, Turkey.
Kaygusuz
Irfan
I
Akpolat
Nusret
N
Keles
Erol
E
Karlidag
Turgut
T
Alpay
Hayrettin Cengiz
HC
Yalcin
Sinasi
S
D000287:Administration, Topical; D000818:Animals; D004195:Disease Models, Animal; D006097:Granulation Tissue / Q000473:pathology*; D006168:Guinea Pigs; D007150:Immunohistochemistry; D008416:Mastoid / Q000187:drug effects* / Q000473:pathology* / Q000601:surgery; D016685:Mitomycin / Q000008:administration & dosage* / Q000009:adverse effects*; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D020556:Neutrophil Infiltration; D011182:Postoperative Care / Q000379:methods; D011336:Probability; D011897:Random Allocation; D012016:Reference Values; D012680:Sensitivity and Specificity
D016685:Mitomycin