Is beta-glucuronidase a clinical useful biomarker for an acute organophosphorus poisoning?
beta-glucuronidase is considered a sensitive biomarker for acute organophosphorus poisoning. In this well-documented study, multiple plasma samples over time were collected. A decrease in plasma concentration of beta-glucuronidase was surprisingly observed, even within normal range. These findings do not support the hypothesis that beta-glucuronidase is a useful biomarker for acute organophosphorus poisoning in humans.
Sabbe
M B
MB
Department of Emergency Medicine, University Hospitals Leuven, Leuven, Belgium. Marc.Sabbe@uzleuven.be
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D000110:Acetylcholinesterase / Q000097:blood; D001285:Atropine / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood*; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D004359:Drug Therapy, Combination; D005440:Fluid Therapy; D005966:Glucuronidase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009768:Obidoxime Chloride / Q000627:therapeutic use; D010278:Parathion / Q000506:poisoning*; D011041:Poisoning / Q000097:blood* / Q000188:drug therapy / Q000201:enzymology; D015742:Propofol / Q000627:therapeutic use; D013406:Suicide, Attempted; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
D015415:Biomarkers; D002800:Cholinesterase Inhibitors; D014662:Vasoconstrictor Agents; D009768:Obidoxime Chloride; D010278:Parathion; D001285:Atropine; D000110:Acetylcholinesterase; D005966:Glucuronidase; D015742:Propofol