title: [A case of ABO*Ael02/O04 genotype with typical phenotype O].
abstract: Ael is a rare blood type which has the least amount of A antigen among A subgroups. It can be detected by special tests performed to resolve the discrepancy between red cell and serum typing in routine serological typing. The presence of A antigen on Ael red cell is demonstrable only by adsorption and elution tests. An Ael individual does not secret A substance in the saliva and may have anti-A antibody in the serum which is usually less reactive with the reagent red cells than anti-B antibody. In Korea, Ael02 has been reported more frequently than other Ael alleles. We report a case of Ael02/O04 who presented as typical phenotype O with strong anti-A and anti-B antibodies and no A antigen detected even by adsorption and elution tests. The case has been proved to be Ael02/O04 by direct sequencing analysis. In individuals with history of discrepancies in the results of ABO phenotyping, ABO genotyping is needed for an accurate evaluation of their blood type.
authors: Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors: Shin-Young
authors: SY
authors: Joo
authors: Yeong Sook
authors: YS
authors: Shim
authors: Mi Jung
authors: MJ
authors: Kim
authors: Hye Lin
authors: HL
authors: Kwon
authors: Kyung
authors: K
authors: Lee
authors: Ho Eun
authors: HE
authors: Chang
authors: Sang Hoon
authors: SH
authors: Song
authors: Kyoung Un
authors: KU
authors: Park
authors: Junghan
authors: J
authors: Song
authors: Kyou Sup
authors: KS
authors: Han
mesh_terms: D000017:ABO Blood-Group System / Q000145:classification / Q000235:genetics*; D000483:Alleles; D002648:Child; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008297:Male; D010375:Pedigree; D010641:Phenotype; D017422:Sequence Analysis, DNA
chemical_list: D000017:ABO Blood-Group System