[Effect of Qingxin Kaiqiao fang on learning and memory ability and morphology of hippocampal nerve cells in AD mice].
OBJECTIVE
To study the effect of the Qingxin Kaiqiao fang on learning and memory ability and shape hippocampal nerve cells in Alzheimer disease (AD).


METHODS
One handred and fifty mice were divid into five groups: blank group, model group, two groups of treatment by Qingxin Kaiqiao fang (14.82, 7.41 g x kg(-1)), piracetan comparison group (0.42 g x kg(-1)). The model group was orally given AlCl3 (200 mg x kg(-1)) every day. For Qingxin Kaiqiaofang and piracetan groups, AlCl3 treatment was given for 6 days at the beginning, followed by giving orally AlCl3 in the morning and drug in the afternoon for 8 weeks. Then, learning and memory aility, the contents of nitric oxide (NO), NO synthase (NOS) and acetylcholinesterase (AchE) in brain, and morphology of hippocampal nerve cells were investigated.


RESULTS
Learning and memory ability of Qingxin Kaiqiaofang groups was improved, compared with comparison group; the difference was significant (P < 0.05, P < 0.01). The drug could prevent hippocampal nerve cells from damaged obviously. The contents of NO, NOS and AchE in mice of treatment groups were lower than those of comparison group; the difference was significant (P < 0.05, P < 0.01).


CONCLUSIONS
Qingxin Kaiqiaofang can improve learning and memory ability of AD mice, prote chippocampal nerve cells, and treat Alzheimer disease.
Hu
Hai-Yan
HY
Wenzhou Medical College Second Clinical College, Wenzhou 325000, China.
Meng
Qiong
Q
Jiang
Zhe
Z
Zhu
Wei-Ming
WM
Eang
Wen-Hua
WH
Zhang
Xiao-Yan
XY
D000110:Acetylcholinesterase / Q000378:metabolism; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006624:Hippocampus / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D009474:Neurons / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D011897:Random Allocation
D004365:Drugs, Chinese Herbal; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D000110:Acetylcholinesterase