Moisturizing effect of oleogel/hydrogel mixtures.
The aim of this study was to obtain new vehicles for topical formulations based on the mixture of hydrogels (aqueous systems) with oleogels (lipophilic systems). Several formulations were prepared using different oleogels mixed with polyacrylic acid hydrogel without addition of other ingredients. The moisturizing effect of the bigels was assessed along with the hydrogel and oleogels used in their preparation by carrying out an in vivo study with 14 healthy volunteers. Corneometer measurements were taken each hour during a five-hour period after product's application. Stability tests (storage at 20 and 40 degrees C for six months) and mechanical characterization were also carried out. Stability tests showed no modifications of the textural properties and appearance over a six-month period at 20 degrees C. At accelerated conditions, modifications of colour and textural properties were detected after six months' storage. While retaining the mechanical and sensory properties of the hydrogel, the bigels showed simultaneously an enhanced moisturizing effect, making them promising candidates for topical formulations.
Almeida
I F
IF
Department of Pharmaceutical Technology, Faculty of Pharmacy, Oporto University, Porto, Portugal.
Fernandes
A R
AR
Fernandes
L
L
Pena Ferreira
M R
MR
Costa
P C
PC
Bahia
M F
MF
D000179:Acrylates / Q000737:chemistry; D000268:Adhesiveness; D000279:Administration, Cutaneous; D000328:Adult; D002784:Cholesterol / Q000737:chemistry; D004355:Drug Stability; D025802:Electric Capacitance; D004983:Ethanolamines / Q000737:chemistry; D005260:Female; D006601:Hexoses / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008899:Mineral Oil / Q000737:chemistry; D009930:Organic Chemicals / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D014677:Pharmaceutical Vehicles / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry; D012824:Silicic Acid / Q000737:chemistry; D012867:Skin / Q000187:drug effects*; D012879:Skin Physiological Phenomena / Q000187:drug effects; D013229:Stearic Acids / Q000737:chemistry; D014867:Water / Q000737:chemistry; D055815:Young Adult
D000179:Acrylates; D004983:Ethanolamines; D006601:Hexoses; D020100:Hydrogels; D009930:Organic Chemicals; D014677:Pharmaceutical Vehicles; D010938:Plant Oils; D013229:Stearic Acids; C016021:oleogels; D014867:Water; D012824:Silicic Acid; C031183:stearic acid; C068582:almond oil; D008899:Mineral Oil; D002784:Cholesterol; C009546:triethanolamine; C453622:carbopol 934P; C009298:sorbitan monostearate