PI3-K and GSK-3: Akt-ing together with microtubules.
Phosphoinositide-3-Kinase (PI3-K) and the downstream kinases Akt and Glycogen Synthase Kinase-3 (GSK-3) have recently been implicated in regulating both microtubule (MT) dynamics and organization. Here we review the role of this signalling pathway in controlling MTs, and explore ways in which the kinases and their substrates may co-operate to spatially regulate MTs in different contexts.
Buttrick
Graham J
GJ
Department of Zoology, University of Oxford, Oxford, United Kingdom.
Wakefield
James G
JG
D000818:Animals; D016764:Cell Polarity; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism*; D006801:Humans; D008870:Microtubules / Q000201:enzymology / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D015398:Signal Transduction
D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3