Medicinal organometallic chemistry: designing metal arene complexes as anticancer agents.
The field of medicinal inorganic chemistry is rapidly advancing. In particular organometallic complexes have much potential as therapeutic and diagnostic agents. The carbon-bound and other ligands allow the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. The establishment of structure-activity relationships and elucidation of the speciation of complexes under conditions relevant to drug testing and formulation are crucial for the further development of promising medicinal applications of organometallic complexes. Specific examples involving the design of ruthenium and osmium arene complexes as anticancer agents are discussed.
Peacock
Anna F A
AF
Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA.
Sadler
Peter J
PJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D020128:Inhibitory Concentration 50; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D017892:Osmium Compounds / Q000737:chemistry / Q000627:therapeutic use; D017671:Platinum Compounds / Q000737:chemistry / Q000627:therapeutic use; D017975:Ruthenium Compounds / Q000737:chemistry / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D017892:Osmium Compounds; D017671:Platinum Compounds; D017975:Ruthenium Compounds