[Effect of diet overloaded by fats on the enzyme systems of metabolism in rats].
The feeding of rats with high-fat diet (a part of fats was 50% of energy value of ration against 20% in control) during 4 weeks increased the level of cytochrome P-450 in the liver and enhanced aniline- and p-nitrophenol hydroxylase activity of CYP2E1 as well as erythromycin N-demethylase activity of CYP3A; the activity of aldehyde dehydrogenase class 3, UDP-glucuronosyl transferase, glutathione-S-transferase and N-acetyl transferase. At the same time, the moderate decrease of indomethacin-O-demethylase of CYP2C both phenolsulfotransferase activity were fixed. The changes of enzymatic activity correlated with activating of processes of gluconeogenesis, glycogenolysis and, especially, ketogenesis. A high-fat diet enhanced reactions of biotransformation of amidopyrine, acetanilide, toluene, sulfadimezine, were catalyzed with CYP2E1, CYP3A and enzymes of conjugation, simultaneously it increased the hepatotoxicity of paracetamol.
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D000082:Acetaminophen / Q000493:pharmacokinetics / Q000633:toxicity; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051381:Rats; D015262:Xenobiotics / Q000493:pharmacokinetics / Q000633:toxicity
D004041:Dietary Fats; D015262:Xenobiotics; D000082:Acetaminophen