Progesterone receptor gene polymorphisms are not associated with preterm birth in a Hispanic population.
OBJECTIVE
To determine whether increased frequency of mutant alleles of the progesterone receptor gene (PGR) was associated with preterm birth in a population of Hispanic women.


METHODS
Placental DNA from 64 patients who had preterm births and 54 control patients was genotyped for 4 progesterone receptor gene polymorphisms by polymerase chain reaction (PCR) restriction fragment length polymorphism. The chi(2) test and t test were used to calculate statistical significance. Linkage disequilibrium was calculated using the Linkage Disequilibrium Analyzer program.


RESULTS
The genotypic frequencies of the 4 polymorphisms were not significantly different between the study and control groups. In addition, there was complete linkage disequilibrium between V660L, H770H, and PROGINS polymorphisms, but not with +331G/A polymorphism.


CONCLUSIONS
The present study suggests that polymorphisms in the progesterone receptor gene are unlikely to be associated with an increased risk of preterm birth in a Hispanic population.
Diaz-Cueto
Laura
L
Research Unit in Reproductive Medicine, UMAE en Ginecologia y Obstetricia, IMSS, Mexico.
Dominguez-Lopez
Pablo
P
Cantillo-Cabarcas
Julio
J
Perez-Figueroa
Gloria
G
Arechavaleta-Velasco
Miguel
M
Arechavaleta-Velasco
Fabian
F
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008800:Mexico; D010920:Placenta; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics*; D011980:Receptors, Progesterone / Q000235:genetics*
D011980:Receptors, Progesterone