title: Acute superior oblique palsy in the monkey: effects of viewing conditions on ocular alignment and modelling of the ocular motor plant.
abstract: We investigated the immediate and long-term changes in static eye alignment with acute superior oblique palsy (SOP) in the monkey. When the paretic eye was patched immediately after the lesion for 6-9 days, vertical alignment slowly improved. When the patch was removed and binocular viewing was allowed, alignment slowly worsened. In contrast when a monkey was not patched immediately after the lesion vertical alignment did not improve. We also show that a model of the eye plant can reproduce the observed acute deficit induced by SOP, but only by abandoning Robinson's symmetric simplification of the reciprocal innervation relationship within pairs of agonist-antagonist muscles. The model also demonstrated that physiologic variability in orbital geometry can have a large impact on SOP deficits.
authors: Laboratory of Sensorimotor Research, National Eye, Institute, Bethesda, MD, USA.
authors: Christian
authors: C
authors: Quaia
authors: Xiaoyan
authors: X
authors: Shan
authors: Jing
authors: J
authors: Tian
authors: Howard
authors: H
authors: Ying
authors: Lance M
authors: LM
authors: Optican
authors: Mark
authors: M
authors: Walker
authors: Rafael
authors: R
authors: Tamargo
authors: David S
authors: DS
authors: Zee
mesh_terms: D000818:Animals; D003290:Convergence, Ocular / Q000502:physiology; D005133:Eye Movements / Q000502:physiology*; D005403:Fixation, Ocular / Q000502:physiology; D000882:Haplorhini; D006801:Humans; D008954:Models, Biological; D013285:Strabismus / Q000503:physiopathology*; D020432:Trochlear Nerve Diseases / Q000503:physiopathology*; D015348:Vision, Binocular / Q000502:physiology*