A polygenic model with common variants may predict lung adenocarcinoma risk in humans.
Genome-wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single-nucleotide polymorphism (SNP) array, in a joint analysis of 2 Italian case-control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6-0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population.
Galvan
Antonella
A
Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy.
Falvella
Felicia S
FS
Spinola
Monica
M
Frullanti
Elisa
E
Leoni
Vera P
VP
Noci
Sara
S
Alonso
Maria R
MR
Zolin
Anna
A
Spada
Elena
E
Milani
Silvano
S
Pastorino
Ugo
U
Incarbone
Matteo
M
Santambrogio
Luigi
L
Gonzalez Neira
Anna
A
Dragani
Tommaso A
TA
D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D002874:Chromosome Mapping; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012907:Smoking