title: Antibacterial activity of halogenated sesquiterpenes from Malaysian Laurencia spp.
abstract: During our studies on Malaysian Laurencia species, brominated metabolites, tiomanene, acetylmajapolene B, and acetylmajapolene A were isolated from an unrecorded species collected at Pulau Tioman, Pahang along with known majapolene B and majapolene A. Acetylmajapolene A was a mixture of diastereomers as in the case of majapolene A. Tiomanene may be a plausible precursor for acetylmajapolenes B and A. In addition, three known halogenated sesquiterpenes and two known halogenated C(15) acetogenins were found from other two unrecorded species collected at Pulau Karah, Terengganu and Pulau Nyireh, Terengganu, respectively. Some of these halogenated metabolites showed moderate antibacterial activity against some marine bacteria.
authors: Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Locked Bag 2073, 88999 Kota Kinabalu, Sabah, Malaysia. csv@ums.edu.my
authors: Charles Santhanaraju
authors: CS
authors: Vairappan
authors: Minoru
authors: M
authors: Suzuki
authors: Takahiro
authors: T
authors: Ishii
authors: Tatsufumi
authors: T
authors: Okino
authors: Tsuyoshi
authors: T
authors: Abe
authors: Michio
authors: M
authors: Masuda
mesh_terms: D000107:Acetylation; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002861:Chromobacterium / Q000187:drug effects; D004885:Erwinia / Q000187:drug effects; D054879:Halogenation; D044722:Laurencia / Q000737:chemistry*; D008296:Malaysia; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011511:Proteus / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014733:Vibrio / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes