Two-vial, LC-MS identification of ephedrine receptors from a solution-phase dynamic combinatorial library of over 9000 components.
Reports on dynamic combinatorial chemistry have almost exclusively involved small libraries of 10-100 compounds. We now show how more than 9000 compounds can be screened in a single LC-MS analysis to reveal a series of new receptors that bind ephedrine in water. These results demonstrate the feasibility of screening DCLs that are substantially larger than the solution-phase libraries reported thus far.
Ludlow
R Frederick
RF
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Otto
Sijbren
S
D002151:Calorimetry / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004809:Ephedrine / Q000737:chemistry* / Q000378:metabolism; D013058:Mass Spectrometry; D011955:Receptors, Drug / Q000737:chemistry* / Q000378:metabolism; D012996:Solutions; D013816:Thermodynamics
D011955:Receptors, Drug; D012996:Solutions; D004809:Ephedrine