Negative motivational control of saccadic eye movement by the lateral habenula.
Reward is crucial for survival of animals and influences animal behaviours. For example, an approaching behaviour to reward is more frequently and quickly elicited when a big reward is expected than when a small reward is expected. Midbrain dopamine neurons are thought to be crucial for such reward-based control of motor behaviour. Indeed, dopamine neurons are excited by cues predicting reward and inhibited by cues predicting no-reward. These excitatory and inhibitory signals would then be used for enhancing and depressing sensorimotor processing, respectively, in the brain areas targeted by dopamine neurons (e.g., striatum). However, it was unknown which parts of the brain provide dopamine neurons with reward-related signals necessary for their responses. We recently showed evidence that the lateral habenula transmits reward-related signals to dopamine neurons, especially to inhibit dopamine neurons. This recent study suggested that the lateral habenula suppresses less rewarding saccadic eye movements by inhibiting dopamine neurons. In the present review, we first summarize anatomical and functional aspects of the lateral habenula. We will then describe our own study. Finally, we will discuss how the lateral habenula, as well as dopamine neurons, contributes to the reward-based control of saccadic eye movements.
Matsumoto
Masayuki
M
Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Hikosaka
Okihide
O
D000818:Animals; D004298:Dopamine / Q000378:metabolism; D019262:Habenula / Q000033:anatomy & histology / Q000502:physiology; D000882:Haplorhini; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D009474:Neurons / Q000378:metabolism; D012201:Reward; D012438:Saccades / Q000502:physiology*
D004298:Dopamine