title: Novel nitrofurazone derivatives endowed with antimicrobial activity.
abstract: The N-alkylated derivatives from nitrofurazone were synthesised and evaluated in vitro for their efficacy as antimicrobial agents against representative strains, including methicillin-resistant Staphylococcus aureus (MRSA). The derivative 2a demonstrated greater activity than the prototype and was comparable to currently used antimicrobial drugs.
authors: LabSINFA - Laboratory for the Planning, Synthesis, and Evaluation of Pharmaceutical Products, Department of Pharmaceutical Science, Centre for Health Science, Federal University of Pernambuco, Recife, PE, Brazil.
authors: Dalci J
authors: DJ
authors: Brondani
authors: Nelly
authors: N
authors: Caetano
authors: Diogo R de M
authors: DR
authors: Moreira
authors: Rogério R
authors: RR
authors: Soares
authors: Vânia T
authors: VT
authors: Lima
authors: Janete M
authors: JM
authors: de Araújo
authors: Fabiane C
authors: FC
authors: de Abreu
authors: Boaz G
authors: BG
authors: de Oliveira
authors: Marcelo Z
authors: MZ
authors: Hernandes
authors: Ana C L
authors: AC
authors: Leite
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009583:Nitrofurazone / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009583:Nitrofurazone