Cerebral metabolic patterns in untreated postmenopausal women with major depressive disorder.
Cerebral metabolic rates were assessed using [(18)F]-fluorodeoxyglucose positron emission tomography in six naturally postmenopausal women with untreated unipolar depression and 11 matched controls. All subjects were hormone therapy-naive and medication-free. Findings include hypermetabolism in the middle frontal gyrus and Broca regions, and hypometabolism in the pons among depressed compared with non-depressed women.
Rasgon
Natalie L
NL
Stanford Center for Neuroscience in Women's Health, Department of Psychiatry and Behavioral Sciences, 401 Quarry Road, Stanford University School of Medicine, Stanford, CA, United States. nrasgon@stanford.edu
Kenna
Heather A
HA
Geist
Cheri
C
Small
Gary
G
Silverman
Daniel
D
D002540:Cerebral Cortex / Q000378:metabolism*; D003865:Major Depressive Disorder / Q000378:metabolism*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004967:Estrogens / Q000172:deficiency; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D011149:Pons / Q000378:metabolism; D017698:Postmenopause / Q000502:physiology*
D004967:Estrogens