[Human magno- and parvo-systems and selective disruptions in their function].
In psychophysical and electrophysiological investigations, we tested the hypothesis that in patients with multiple sclerosis at its early stage either phasic cells of the magnocellular pathway or tonic cells of the parvocellular pathway are disturbed. Healthy humans and patients with early stage of diseases have a contrast spatial-frequency sensitivity measure. The decrease in sensitivity at low, medium and high spatial frequency indicates changes in parvo- and magno-system activity. The data are separated into two clusters. Psychophysical data is in good accordance with electrophysiological data of visual evoked potentials (VEPs). First group of patients showed changes of the amplitude of positive wave P100 whereas in second group of patients changes of negative wave N80 dominated comparative to healthy subjects. According to some literature data these changes were specific for M-pathway and for P-pathway.
Murav'eva
S V
SV
Deshkovich
A A
AA
Shelepin
Iu E
IuE
D000293:Adolescent; D000328:Adult; D015350:Contrast Sensitivity; D005074:Evoked Potentials, Visual; D006801:Humans; D009103:Multiple Sclerosis / Q000503:physiopathology* / Q000523:psychology; D010775:Photic Stimulation; D014795:Visual Pathways