Current treatment concepts for neuromas-in-continuity.
A neuroma-in-continuity is a neuroma that results from failure of the regenerating nerve growth cone to reach peripheral targets. It occurs within an intact nerve in response to internally damaged fascicles, resulting in a distal portion of the nerve that no longer functions properly. Management of neuromas-in-continuity is challenging. Chemical methods, and microsurgical techniques including fascicular ligation, and burying into muscle and bone have been reported to prevent neuroma-in-continuity formation. The purpose of this article is to present novel techniques for neuroma-in-continuity management, and to discuss the related literature.
Mavrogenis
Andreas F
AF
First Department of Orthopaedics, Athens University Medical School, Athens, Greece. andreasfmavrogenis@yahoo.gr
Pavlakis
Kitty
K
Stamatoukou
Anna
A
Papagelopoulos
Panayiotis J
PJ
Theoharis
Stamatios
S
Zoubos
Aristidis B
AB
Zhang
Zijie
Z
Soucacos
Panayotis N
PN
D000818:Animals; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use; D008866:Microsurgery / Q000379:methods; D009463:Neuroma / Q000209:etiology / Q000628:therapy*; D019635:Neurosurgical Procedures / Q000379:methods; D009498:Neurotoxins / Q000627:therapeutic use; D059348:Peripheral Nerve Injuries; D010524:Peripheral Nervous System Neoplasms / Q000209:etiology / Q000628:therapy*
D000922:Immunotoxins; D009498:Neurotoxins