title: One-step chromoendoscopy and structure enhancement using balsamic vinegar for screening of Barrett's esophagus.
abstract: OBJECTIVE
  Screening for specialized columnar epithelium (SCE) within columnar lined esophagus (CLE) with standard video endoscopes is not reliable enough. Several methods to improve accuracy of predicting presence of SCE like chromoendoscopy with vital stains or structure enhancement with acetic acid have been introduced but data up to now remains controversial. The present prospective study was conducted to evaluate a combination of chromoendoscopy and acetic acid structure enhancement using the naturally brownish coloured balsamic vinegar during routine upper endoscopy.
  
  
  METHODS
  Between March and July 2006 20 patients with macroscopic suspicion for SCE during routine endoscopy were included prospectively. Saline diluted balsamic vinegar (3%) was administered with a spraying catheter at the distal esophagus. After 1 minute the distal esophagus was evaluated for the presence of SCE according to the mucosal surface pattern (pattern I-II: round pits/circular pattern predicting gastric epithelium; pattern III-IV: ridged/villous pattern predicting Barrett's epithelium). Only HR-videoendoscopes without magnification were used. After presence or absence of SCE was defined by the endoscopist targeted biopsies of the CLE were performed. Histological results were compared with endoscopic findings.
  
  
  RESULTS
  In 9 of 20 patients (13 male, 7 female; mean age 60.0 +/- 12.8 years) biopsy specimen revealed SCE within CLE on histology. Prediction of BM after balsamic vinegar staining was possible in all cases. Surface pattern I-II was found in 9 patients and pattern III-IV in 11 patients. Accuracy, sensitivity and specificity for BV staining predicting SCE were 90%, 100% and 82%, respectively.
  
  
  CONCLUSIONS
  Chromoendoscopy with balsamic vinegar combines the advantages of chromoendoscopy and structure enhancement by acetic acid for detection of SCE. The reliability in predicting the presence of SCE was high in this prospective feasibility study.
authors: Department of Medicine II, HSK Wiesbaden, Teaching Hospital of the University of Mainz, Germany. oliver.pech@t-online.de
authors: Oliver
authors: O
authors: Pech
authors: Maria C
authors: MC
authors: Petrone
authors: Hendrik
authors: H
authors: Manner
authors: Thomas
authors: T
authors: Rabenstein
authors: Andrea
authors: A
authors: May
authors: Jürgen
authors: J
authors: Pohl
authors: Christian
authors: C
authors: Ell
mesh_terms: D019342:Acetic Acid / Q000008:administration & dosage; D001471:Barrett Esophagus / Q000175:diagnosis*; D001706:Biopsy; D003937:Diagnosis, Differential; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007202:Indicators and Reagents / Q000008:administration & dosage*; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D007202:Indicators and Reagents; D019342:Acetic Acid