Controlled release solid dosage forms using combinations of (meth)acrylate copolymers.
Controlled release solid oral dosage forms have been widely used for decades, enabling drugs to be administered more comfortably while at the same time providing a sustained and reproducible method of release. (Meth)acrylate copolymers are one of the options available when considering a sustained release solid form. Due to their different functionalities it is possible to achieve various different release profiles. The electrical character of these copolymers and their pH-dependent solubility can result in new and modified patterns when these polymers are combined. This review sheds light on various studies involving combinations of (meth)acrylate copolymers for use in multi-unit systems and matrix tablets, and also on several analytical methods that help to identify possible interactions between these polymers.
Gallardo
Diego
D
EVONIK Industries, Pharma Polymers, Kirschenallee, Darmstadt, Germany. diego.gallardo@evonik.com
Skalsky
Brigitte
B
Kleinebudde
Peter
P
D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012995:Solubility; D013607:Tablets
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer