title: Antifungal saponins from Paris polyphylla Smith.
abstract: Three steroidal saponins, including one new and two known compounds, were isolated from the rhizomes of Paris polyphylla Smith. One- and two-dimensional NMR, LC-MS, and interpretation of hydrolytic cleavage experiments led to the identification of the structure of the new saponin as ( 25R)-spirost-5-ene-3 beta,17 alpha-diol (pennogenin) 3- O-{ O- alpha- L-rhamnopyranosyl-(1-->2)- O-[ O- beta-xylopyranosyl-(1-->5)- alpha- L-arabinofuranosyl-(1-->4)]- beta- D-glucopyranoside}. The isolated saponins were evaluated for their antifungal activity against Cladosporium cladosporioides and Candida species and showed comparable activity to chemicals used in some commercial products.
authors: HortResearch, Ruakura Research Centre, Hamilton, New Zealand. ddeng@hortresearch.co.nz
authors: Dawei
authors: D
authors: Deng
authors: Denis R
authors: DR
authors: Lauren
authors: Janine M
authors: JM
authors: Cooney
authors: Dwayne J
authors: DJ
authors: Jensen
authors: Kirstin V
authors: KV
authors: Wurms
authors: Jenine E
authors: JE
authors: Upritchard
authors: Richard D
authors: RD
authors: Cannon
authors: Ming Zhong
authors: MZ
authors: Wang
authors: Ming Zhang
authors: MZ
authors: Li
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D019668:Liliaceae / Q000737:chemistry*; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D004365:Drugs, Chinese Herbal; D012503:Saponins