title: VEGF and M-CSF levels in periodontal tissue during tooth movement.
abstract: It has been reported that both vascular endothelial growth factor (VEGF) and macrophage colonystimulating factor (M-CSF) can induce osteoclast recruitment. Thus, VEGF and M-CSF are considered to be closely involved in the bone remodeling process. The purpose of this study was to evaluate changes in VEGF and M-CSF expression during orthodontic treatment. The expression of VEGF and M-CSF mRNA in osteoblasts and fibroblasts was detected by in situ hybridization during experimental tooth movement in mice. Furthermore, the canine retraction side and the control side of orthodontic patients were compared, revealing a statistically significant increase in both VEGF and M-CSF concentrations in gingival crevicular fluid. These results suggest that orthodontic tooth movement causes an increase in VEGF and M-CSF levels. These factors may induce bone remodeling via osteoclastic bone resorption.
authors: Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan. mkaku@hiroshima-u.ac.jp
authors: Masato
authors: M
authors: Kaku
authors: Masahide
authors: M
authors: Motokawa
authors: Yuiko
authors: Y
authors: Tohma
authors: Natsumi
authors: N
authors: Tsuka
authors: Hiroyuki
authors: H
authors: Koseki
authors: Hiroko
authors: H
authors: Sunagawa
authors: Rene
authors: R
authors: Arturo Marquez Hernandes
authors: Junji
authors: J
authors: Ohtani
authors: Tadashi
authors: T
authors: Fujita
authors: Toshitsugu
authors: T
authors: Kawata
authors: Kazuo
authors: K
authors: Tanne
mesh_terms: D000293:Adolescent; D000818:Animals; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D006801:Humans; D017403:In Situ Hybridization; D016173:Macrophage Colony-Stimulating Factor / Q000235:genetics / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D010519:Periodontium / Q000166:cytology / Q000378:metabolism*; D014087:Tooth Movement Techniques; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*
chemical_list: D042461:Vascular Endothelial Growth Factor A; D016173:Macrophage Colony-Stimulating Factor