title: Unusual production of glutathione in Actinobacteria.
abstract: Most Actinobacteria produce mycothiol as the major thiol. In addition to mycothiol Rhodococcus AD45 generates a substantial level of glutathione possibly using genes acquired in a lateral transfer. Instead of mycothiol, Rubrobacter radiotolerans and Rubrobacter xylanophilus produce glutathione, whose synthesis appears to involve enzymes substantially different from those in other organisms.
authors: Department of Biology, California State University-Fresno, Fresno, CA 93740, USA.
authors: Todd
authors: T
authors: Johnson
authors: Gerald L
authors: GL
authors: Newton
authors: Robert C
authors: RC
authors: Fahey
authors: Mamta
authors: M
authors: Rawat
mesh_terms: D039903:Actinobacteria / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D003545:Cysteine / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D006020:Glycopeptides / Q000378:metabolism; D007294:Inositol / Q000378:metabolism; D008969:Molecular Sequence Data; D016415:Sequence Alignment
chemical_list: D001426:Bacterial Proteins; D006020:Glycopeptides; C089265:mycothiol; D007294:Inositol; D005978:Glutathione; D003545:Cysteine