title: Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer.
abstract: The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics.
authors: Department of Medical Biology, Marmara University, School of Medicine, 34668 Istanbul, Turkey. akkiprik@yahoo.com
authors: Mustafa
authors: M
authors: Akkiprik
authors: Yumei
authors: Y
authors: Feng
authors: Huamin
authors: H
authors: Wang
authors: Kexin
authors: K
authors: Chen
authors: Limei
authors: L
authors: Hu
authors: Aysegul
authors: A
authors: Sahin
authors: Savitri
authors: S
authors: Krishnamurthy
authors: Ayse
authors: A
authors: Ozer
authors: Xishan
authors: X
authors: Hao
authors: Wei
authors: W
authors: Zhang
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D049109:Cell Proliferation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018975:Insulin-Like Growth Factor Binding Protein 5 / Q000378:metabolism*; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism; D008495:Medical Oncology / Q000379:methods; D051379:Mice; D011379:Prognosis; D017434:Protein Structure, Tertiary; D014158:Transcription, Genetic
chemical_list: D018975:Insulin-Like Growth Factor Binding Protein 5; D018969:Insulin-Like Growth Factor Binding Proteins