title: Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans.
abstract: Our aim was to investigate the effects of an oral supplementation of quercetin at 3 different doses on plasma concentrations of quercetin, parameters of oxidant/antioxidant status, inflammation, and metabolism. To this end, 35 healthy volunteers were randomly assigned to take 50, 100, or 150 mg/d (group Q50-Q150) quercetin for 2 wk. Fasting blood samples were collected at the beginning and end of the supplementation period. Compared with baseline, quercetin supplementation significantly increased plasma concentrations of quercetin by 178% (Q50), 359% (Q100), and 570% (Q150; P < 0.01 for all). High interindividual variation was found for plasma quercetin concentrations (36-57%). Quercetin did not affect concentrations of serum uric acid or plasma alpha- and gamma-tocopherols, oxidized LDL, and tumor necrosis factor-alpha, or plasma antioxidative capacity as assessed by the ferric-reducing antioxidant potential and oxygen radical absorbance capacity assays. In addition, serum lipids and lipoproteins, body composition, and resting energy expenditure did not significantly change during quercetin supplementation. Pharmacokinetics of quercetin were investigated in a subgroup of 15 volunteers. The areas under the plasma concentration-time curves ranged from 76.1 mumol.min.L(-1) to 305.8 mumol.min.L(-1) (50- and 150-mg dosages, respectively). Median maximum plasma concentrations of quercetin (431 nmol/L) were observed 360 min after intake of 150 mg quercetin. In conclusion, daily supplementation of healthy humans with graded concentrations of quercetin for 2 wk dose-dependently increased plasma quercetin concentrations but did not affect antioxidant status, oxidized LDL, inflammation, or metabolism.
authors: Institute of Human Nutrition and Food Science and 4Institute of Animal Nutrition, Physiology and Metabolism, Christian-Albrechts-University Kiel, 24105 Kiel, Germany.
authors: Sarah
authors: S
authors: Egert
authors: Siegfried
authors: S
authors: Wolffram
authors: Anja
authors: A
authors: Bosy-Westphal
authors: Christine
authors: C
authors: Boesch-Saadatmandi
authors: Anika Eva
authors: AE
authors: Wagner
authors: Jan
authors: J
authors: Frank
authors: Gerald
authors: G
authors: Rimbach
authors: Manfred James
authors: MJ
authors: Mueller
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019587:Dietary Supplements; D004187:Disaccharides / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004734:Energy Metabolism; D005260:Female; D044948:Flavonols / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D009747:Nutritional Physiological Phenomena; D018384:Oxidative Stress / Q000502:physiology; D011794:Quercetin / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D000975:Antioxidants; D004187:Disaccharides; D044948:Flavonols; C047368:3-methylquercetin; C508967:tamarixetin; D011794:Quercetin