Evaluation of chitosan gel as antibiotic and photosensitizer delivery.
This work suggests the use of chitosan gel imbued with the photosensitizer Photogem and with the antibiotic Tetraclin as a possible drug delivery system. The results reveal a decrease in the photosensitizer level of toxicity. Besides, the interaction between Photogem and chitosan gel causes a red shift in the photosensitizer spectrum, increasing its absorption in the therapeutic window (600-700 nm). These characteristics indicate this compound as a promising natural polymer-based photosensitizer carrier for photodynamic therapy. In summary, our results show that pure and doped chitosan gel may have potential application for antimicrobial action, being an excellent alternative when local control of the drug administration, provided by the gel, is required.
Fontana
Carla Raquel
CR
Department of Periodontology, School of Dentistry at Araraquara, UNESP Araraquara, SP, Brazil. cfontana@if.sc.usp.br
dos Santos
David Sotero
DS
Bosco
Joseane Maria
JM
Spolidorio
Denise M
DM
Chiérici Marcantonio
Rosemary Adriana
RA
D000277:Adjuvants, Pharmaceutic / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D016503:Drug Delivery Systems; D004357:Drug Synergism; D005782:Gels; D006490:Hemostatics / Q000737:chemistry / Q000494:pharmacology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D013752:Tetracycline / Q000008:administration & dosage*
D000277:Adjuvants, Pharmaceutic; D000900:Anti-Bacterial Agents; D005782:Gels; D006490:Hemostatics; D017319:Photosensitizing Agents; D048271:Chitosan; D013752:Tetracycline