[Comparision study pharmacokinetics of different source cinnamon acid].
OBJECTIVE
To study relatively pharmacological activities of cinnamon acid in blood serum of rabbit administered cinnamon acid, cinnamon and Jingui Shenqi pills.


METHODS
RP-HPLC determine and analysis blood serum sample from rabbits administered cinnamon acid, cinnamon and Jingui Shenqi pills. Condition of colour spectrum was Symmetry C18 (3.9 mm x 150 mm, 5 microm) chromato bar, mobile phase was methanol-1% glacial acetic acid water-solution (45:55), flow rate was 0.8 mL x min(-1), temperature of bar was 35 degrees C, detection wave length was 285 nm. The serum pharmacokinetic parameters were calculated with 3p87.


RESULTS
Linear range of cinnamon acid is from 0.06-15 microg x mL(-1) (r = 0.9997), the lowest detectability is 0.054 microg x mL(-1). Pharmacokinetic process of cinnamon acid in rabbit could be all fitted to two-compartment model.


CONCLUSIONS
Sensitive and exclusive HPLC that adopt can exactly detect serum concentration in rabbits administerd cinnamon acid. Pharmacokinetic parameters of three conditions can reveal pharmacokinetics regularity of cinnamon acid in rabbit.
Li
Wen-Lan
WL
Center of Research on Life Sciences and Environmental Sciences, Harbin University of Commerce Harbin 150076, China. lwldzd@163.com
Whang
Xiao-Dong
XD
Ji
Yu-Bin
YB
Hu
Zheng-Ting
ZT
Ren
Xiao-Lei
XL
Whang
Jia
J
D000818:Animals; D002935:Cinnamomum zeylanicum / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D011817:Rabbits; D044967:Serum / Q000737:chemistry / Q000187:drug effects
D004365:Drugs, Chinese Herbal