title: Chinese herbal medicine for Mild Cognitive Impairment and Age Associated Memory Impairment: a review of randomised controlled trials.
abstract: This review assesses the effectiveness and safety of Chinese herbal medicines (CHM) for Mild Cognitive Impairment (MCI) and Age Associated Memory Impairment (AAMI). Electronic searches of English and Chinese databases and hand searches of Chinese journal holdings were conducted. Randomised controlled trials comparing orally administered CHM with placebo, no intervention or other therapy were considered. Ginkgo biloba was excluded. Ten trials met inclusion criteria. Eight different CHM were investigated. Methodological quality was assessed using the Jadad scale and five studies scored three or above. Two studies compared CHM with placebo and eight with another intervention. This review found an overall benefit on some outcome measures for the eight CHMs involved in the 10 RCTs but methodological and data reporting issues were evident. Meta-analysis of three studies found the effects of the CHMs were at least equivalent to piracetam on Mini-Mental State Examination (MMSE) scores. No severe adverse events were reported.
authors: WHO Collaborating Centre for Traditional Medicine, Division of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, VIC, 3083, Australia.
authors: Brian H
authors: BH
authors: May
authors: Angela W H
authors: AW
authors: Yang
authors: Anthony L
authors: AL
authors: Zhang
authors: Michael D
authors: MD
authors: Owens
authors: Louise
authors: L
authors: Bennett
authors: Richard
authors: R
authors: Head
authors: Lynne
authors: L
authors: Cobiac
authors: Chun Guang
authors: CG
authors: Li
authors: Helmut
authors: H
authors: Hugel
authors: David F
authors: DF
authors: Story
authors: Charlie C L
authors: CC
authors: Xue
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000523:psychology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000188:drug therapy* / Q000523:psychology; D008609:Mental Status Schedule; D008875:Middle Aged; D018697:Nootropic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D018697:Nootropic Agents