Expression of integrin-linked kinase and its binding partners in chondrosarcoma: association with prognostic significance.
Integrin-linked kinase (ILK) and its binding partners alpha-parvin, beta-parvin, Mig-2 and Migfilin are important components of the cell-matrix adhesions implicated in cell motility, growth, survival and ultimately carcinogenesis. Herein, we investigated immunohistochemically the expression of these molecules in cartilaginous neoplasms and explored their involvement in chondrosarcoma pathobiology and behaviour. Our analyses revealed that ILK, alpha-parvin, beta-parvin and Mig-2 are expressed in the majority of chondrosarcomas but in a small proportion of enchondromas, implying that these proteins might have a role in the development and progression of chondrogenic neoplasms. Moreover, our findings highlight the possibilities that ILK might serve as biological marker that could accurately predict a high-grade tumour and that Mig-2 may function as a promising prognostic indicator of high-risk patients.
Papachristou
Dionysios J
DJ
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Gkretsi
Vassiliki
V
Rao
Uma N M
UN
Papachristou
Georgios I
GI
Papaefthymiou
Odysseas A
OA
Basdra
Efthimia K
EK
Wu
Chuanyue
C
Papavassiliou
Athanasios G
AG
D000185:Actinin / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000201:enzymology* / Q000401:mortality; D015815:Cell Adhesion Molecules; D002813:Chondrosarcoma / Q000201:enzymology* / Q000401:mortality; D003598:Cytoskeletal Proteins; D005260:Female; D006801:Humans; D051457:Hyaline Cartilage / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008840:Microfilament Proteins; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D016019:Survival Analysis; D000099200:Scaffold Protein ILK; D000096985:Calponins
D000185:Actinin; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D009363:Neoplasm Proteins; D017346:Protein Serine-Threonine Kinases; D000099200:Scaffold Protein ILK; C473794:FBLIM1 protein, human; C477322:FERMT3 protein, human; C486590:PARVA protein, human; D000096985:Calponins; C486591:PARVB protein, human