Catalytic enantioselective aldol additions of alpha-isothiocyanato imides to aldehydes.
Highly enantioselective organocatalytic aldol additions of alpha-isothiocyanato imides to aldehydes are reported. These reactions provide convenient access to enantiomerically enriched and protected beta-hydroxy-alpha-amino acids with catalyst loadings as low as 1 mol%.
Li
Le
L
Department of Chemistry and Chemical Biology, Rutgers, State University of New Jersey, Piscataway, New Jersey 08854, USA.
Klauber
Eric G
EG
Seidel
Daniel
D
D000447:Aldehydes / Q000138:chemical synthesis*; D000596:Amino Acids / Q000138:chemical synthesis; D002384:Catalysis; D007094:Imides / Q000737:chemistry*; D017879:Isothiocyanates / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D000596:Amino Acids; D007094:Imides; D017879:Isothiocyanates