Variants in the nestin gene and coronary heart disease.
BACKGROUND
The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported.


RESULTS
The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02).


CONCLUSIONS
Nestin gene variants are associated with early-onset CHD. Further research on nestin's role in atherosclerosis is required.
Meng
Weihua
W
Department of Medicine, Institute of Clinical Science, Queen's University Belfast, Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast, Northern Ireland, UK.
Patterson
Chris C
CC
Belton
Christine
C
Hughes
Anne
A
McKeown
Pascal P
PP
D000328:Adult; D017668:Age of Onset; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics*; D007494:Ireland; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D064231:Nestin; D020641:Polymorphism, Single Nucleotide
D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; D064231:Nestin