Cmv1 and natural killer cell responses to murine cytomegalovirus infection.
The dissection of genetic resistance to murine cytomegalovirus infection in inbred laboratory mouse strains led to the identification of a natural killer cell activation receptor that recognizes a virus-encoded protein. Herein, we summarize the genetic approach and findings that have provided novel insights into innate immune control of virus infections.
Scalzo
A A
AA
Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Nedlands, Austaralia.
Yokoyama
W M
WM
D000818:Animals; D000950:Antigens, Ly / Q000235:genetics* / Q000502:physiology; D002874:Chromosome Mapping; D020022:Genetic Predisposition to Disease; D006566:Herpesviridae Infections / Q000235:genetics / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D037181:Lectins, C-Type / Q000235:genetics* / Q000502:physiology; D051379:Mice; D018146:Muromegalovirus; D055650:NK Cell Lectin-Like Receptor Subfamily A; D051920:NK Cell Lectin-Like Receptor Subfamily D / Q000502:physiology; D055630:Receptors, NK Cell Lectin-Like
D000950:Antigens, Ly; C527096:Klra8 protein, mouse; D037181:Lectins, C-Type; D055650:NK Cell Lectin-Like Receptor Subfamily A; D051920:NK Cell Lectin-Like Receptor Subfamily D; D055630:Receptors, NK Cell Lectin-Like