title: In vitro permeation studies of nanoemulsions containing ketoprofen as a model drug.
abstract: We prepared a nanoemulsion system with benzyl alcohol/ ethanol/Solutol/smash(R) HS 15 /water. Ketoprofen was used as a model drug in this study. The nanoemulsions of this system evidenced a high degree of stability. The droplet diameter did not change over a period of at least 3 months. The nanoemulsion containing 4% benzyl alcohol evidenced a permeation rate higher than was observed with the 1% and 2% nanoemulsions. Also the nanoemulsion containing 1% Solutol(R) HS 15 provided a permeation rate higher than was seen with the 2% and 4% nanoemulsions. All ketoprofen-loaded nanoemulsions enhanced the in vitro permeation rate through mouse skins as compared to the control.
authors: Laboratory of Enzyme Technology, College of Natural Science, Chonju, Republic of Korea.
authors: Beom Su
authors: BS
authors: Kim
authors: Myoung
authors: M
authors: Won
authors: Kang Min
authors: KM
authors: Lee
authors: Cheo Sang
authors: CS
authors: Kim
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D019905:Benzyl Alcohol / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D004355:Drug Stability; D004655:Emulsions; D000431:Ethanol / Q000737:chemistry; D066298:In Vitro Techniques; D007660:Ketoprofen / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D051379:Mice; D053758:Nanoparticles; D010316:Particle Size; D010539:Permeability; D011092:Polyethylene Glycols / Q000737:chemistry; D012867:Skin / Q000378:metabolism*; D013229:Stearic Acids / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D004655:Emulsions; D013229:Stearic Acids; D014867:Water; D000431:Ethanol; D011092:Polyethylene Glycols; C067028:Solutol HS 15; D007660:Ketoprofen; D019905:Benzyl Alcohol