title: The use of microbeams to investigate radiation damage in living cells.
abstract: The micro-irradiation technique continues to be highly relevant to a number of radiobiological studies in vitro. In particular, studies of the bystander effect show that direct damage to cells is not the only trigger for radiation-induced effects, but that unirradiated cells can also respond to signals from irradiated neighbours. Furthermore, the bystander response can be initiated even when no energy is deposited in the genomic DNA of the irradiated cell (i.e. by targeting just the cytoplasm).
authors: Gray Cancer Institute, University of Oxford, PO Box 100, Mount Vernon Hospital, Northwood HA6 2JR, UK. folkard@gci.ac.uk
authors: Melvyn
authors: M
authors: Folkard
authors: Kevin M
authors: KM
authors: Prise
authors: Geoff
authors: G
authors: Grime
authors: Karen
authors: K
authors: Kirkby
authors: Borivoj
authors: B
authors: Vojnovic
mesh_terms: D000818:Animals; D024201:Bystander Effect / Q000528:radiation effects*; D002477:Cells / Q000528:radiation effects*; D003593:Cytoplasm / Q000528:radiation effects; D004247:DNA / Q000528:radiation effects; D016678:Genome; D006801:Humans
chemical_list: D004247:DNA