title: ECMO for cardiac rescue in a neonate with accidental amiodarone overdose.
abstract: Intravenous (IV) amiodarone hydrochloride has proven to be a very effective antiarrhythmic treatment option for a variety of ventricular and supraventricular arrhythmias in adults and paediatric patients. Amiodarone is known to have significant side effects and these especially include profound hypotension in animals and adults, vasodilatation, negative inotropic effects, and significant bradycardia especially when administered intravenously. Special caution is warranted in patients with decreased contractility and end-stage heart failure. We present a case of accidental amiodarone overdose in a newborn treated for atrial flutter resulting in cardiovascular collapse. The patient could be rescued by rapid initiation of VA-ECMO treatment. The patient survived without neurological damage.
authors: Dept. of Congenital Heart Defects Heart and Diabetes Center, North-Rhine Westphalia, Georgstrasse 11, 32545, Bad Oeynhausen, Germany. nikhaas@hdz-nrw.de
authors: Nikolaus Alexander
authors: NA
authors: Haas
authors: Christine
authors: C
authors: Wegendt
authors: Rainer
authors: R
authors: Schäffler
authors: Günther
authors: G
authors: Kirchner
authors: Eva
authors: E
authors: Welisch
authors: Katharina
authors: K
authors: Kind
authors: Ute
authors: U
authors: Blanz
authors: Deniz
authors: D
authors: Kececioglu
mesh_terms: D000638:Amiodarone / Q000506:poisoning* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000506:poisoning* / Q000627:therapeutic use; D001282:Atrial Flutter / Q000188:drug therapy; D062787:Drug Overdose; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone