title: Impact of wide-angle, high-definition endoscopy in the diagnosis of colorectal neoplasia: a randomized controlled trial.
abstract: OBJECTIVE
  It is essential to optimize standard colonoscopy technique to be able to increase polyp detection. We sought to compare the performance of colonoscopy using a high-definition, wide-angle endoscope (HDE) versus a standard colonoscope (SC) for the detection of colorectal neoplasia.
  
  
  METHODS
  All consecutive consenting adult patients referred from primary care centers were included and randomly assigned at a 1:1 ratio to undergo HDE or SC. Times to reach and withdraw from the cecum were measured. Morphology, size, location, and pathologic diagnosis of each polyp were recorded. Sample size calculation resulted in a total of 682 patients needed.
  
  
  RESULTS
  A total of 693 consecutive patients fulfilled all inclusion criteria (73 excluded owing to insufficient bowel preparation). Each arm included 310 patients with no baseline characteristic differences. Time to reach the cecum was slightly superior for SC (8.9 +/- 4.8 minutes vs 8.2 +/- 4.5 minutes; P = .055). Pathology examination was feasible in 418 lesions (272 adenomas, 109 hyperplastic polyps, and 37 inflammatory lesions). Both techniques detected a similar number and type of lesions, and there were no differences in the distribution along the colon, in the degree of dysplasia, or morphology of adenomas. The per-patient basis analyses demonstrated that there were no differences between the 2 arms of the study in the detection rates of polyps (SC, 0.84 +/- 1.59; HDE, 0.83 +/- 1.30), adenomas (0.45 +/- 1.07 vs 0.43 +/- 0.87), small adenomas (0.22 +/- 0.71 vs 0.28 +/- 0.78), flat adenomas (0.30 +/- 0.91 vs 0.21 +/- 0.63), or hyperplastic polyps (0.16 +/- 0.50 vs 0.18 +/- 0.54).
  
  
  CONCLUSIONS
  HDE did not detect significantly more colorectal neoplasia than SC.
authors: Gastroenterology Department, Endoscopy Unit, Institut de Malalties Digestives i Metabòliques, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Spain. mpellise@clinic.ub.es
authors: Maria
authors: M
authors: Pellisé
authors: Glòria
authors: G
authors: Fernández-Esparrach
authors: Andrés
authors: A
authors: Cárdenas
authors: Oriol
authors: O
authors: Sendino
authors: Elena
authors: E
authors: Ricart
authors: Eva
authors: E
authors: Vaquero
authors: Antonio Z
authors: AZ
authors: Gimeno-García
authors: Cristina Rodríguez
authors: CR
authors: de Miguel
authors: Michel
authors: M
authors: Zabalza
authors: Angels
authors: A
authors: Ginès
authors: Josep M
authors: JM
authors: Piqué
authors: Josep
authors: J
authors: Llach
authors: Antoni
authors: A
authors: Castells
mesh_terms: D000236:Adenoma / Q000473:pathology; D018256:Adenomatous Polyps / Q000473:pathology*; D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D020776:Endoscopes, Gastrointestinal; D016099:Endoscopy, Gastrointestinal / Q000379:methods* / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D015203:Reproducibility of Results