title: The role of hepatitis B virus x gene in development of primary hepatocellular carcinoma.
abstract: Primary hepatocellular carcinoma (HCC) is one of the most common cancers occurring in human, and there is strong epidemiological evidence suggesting that persistent hepatitis B virus (HBV) infection is the most important risk factor for its development.HBx gene was found to be a transactivator recently. Its continuous expression in hepatocytes may transactivate cellular genes which can play a certain role in development of HCC. TheHBx gene fragment was used to construct a recombinant eukaryotic expression vector pCEP4 and introduced into HepG2 cells. The effect ofHBx gene on HCC cells growth and its molecular mechanism in HCC cells regulation were investigated.
authors: The first Affiliated Hospital, Chongqing University of Medical Sciences, 400016, Chongqing, China, taoxiaohong@163.net.
authors: X
authors: X
authors: Tao
authors: D
authors: D
authors: Shen
authors: H
authors: H
authors: Ren
authors: X
authors: X
authors: Zhang
authors: D
authors: D
authors: Zhang
authors: B
authors: B
authors: Gu
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authors: J
authors: Ye