Short synthesis of (-)-cephalotaxine using a radical cascade.
The short total synthesis of (-)-cephalotaxine is described. The concise construction of the pentacyclic core of this alkaloid was achieved by a radical cascade involving 7-endo and 5-endo cyclizations.
Taniguchi
Tsuyoshi
T
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
Ishibashi
Hiroyuki
H
D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry*; D006248:Harringtonines / Q000138:chemical synthesis* / Q000737:chemistry; D000077863:Homoharringtonine; D013237:Stereoisomerism
D005609:Free Radicals; D006248:Harringtonines; D000077863:Homoharringtonine