Alterations of cardiac and lymphocyte beta- adrenoceptors in rat with chronic heart failure.
The alterations of cardiac and lymphocyte beta-adrenoceptors were observed in the rats with chronic heart failure produced by constriction of both abdominal aorta and renal artery. The results showed that beta(1)-adrenoceptor density and mRNA levels were increased, whereas these levels remained unchanged for beta(2). The concentrationcontractile response curve for isoproterenol was shifted m the right in cardiac atrium, whereas the concentration-CAMP accumulation response curve for isoproterenol in myocardium was not changed. The number of beta-adrenoceptom in blood lymphocyte was markedly reduced. Thus in the heart-failure rats the density of cardiac beta-adrenoceptor was increased accompanying reduced beta-adrenoceptormediated positive inotropic response, suggesting a post adenylate cyclase dysfunction or impaired contractile components. In contrast, the alteration of beta-adrenoceptor in lymphocyte is consistent with the reduced beta-adrenoceptor-mediated inotropic response in heart.
Zhang
P
P
Institute of Vascular Medicine, Third Hospital, Beijing Medical University, 100083, Beijing, China.
Han
Q
Q
Zhang
Y
Y
Xu
K
K
Tian
B
B
Lü
Z
Z
Guo
J
J
Chen
M
M