title: No association between epidermal growth factor and epidermal growth factor receptor polymorphisms and nasopharyngeal carcinoma.
abstract: Numerous candidate genes have been proposed as susceptibility factors for the development of nasopharyngeal carcinoma (NPC). Epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) interaction plays a pivotal role in cell proliferation, differentiation, and tumourigenesis of epithelial tissues. To our knowledge, however, no study has examined the relationship between the EGF/EGFR and NPC. The aim of this study is to investigate the potential association between single-nucleotide polymorphisms of EGF +61 G/A and EGFR +2073 A/T and NPC. A total of 173 patients with NPC and 206 age- and sex-matched controls were the participants. Genotypes were determined using a polymerase chain reaction-restriction fragment length polymorphism strategy and DNA sequencing. There were no significant differences in the genotype and allele frequencies of EGF +61 G/A and EGFR +2073 A/T polymorphisms between the group of patients with NPC and the control group in a Chinese population (for EGF +61 G/A: OR=1.29, 95% CI: 0.95-1.74; for EGFR +2073 A/T: OR=0.91, 95% CI: 0.67-1.23). Further studies are still needed to explore the complicated interaction between environmental factors and EGF +61 G/A and EGFR +2073 A/T polymorphisms in the risk of NPC, particularly in ethnically different populations.
authors: Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
authors: Lin-Bo
authors: LB
authors: Gao
authors: Ye-Sheng
authors: YS
authors: Wei
authors: Bin
authors: B
authors: Zhou
authors: Yan-Yun
authors: YY
authors: Wang
authors: Wei-Bo
authors: WB
authors: Liang
authors: Cui
authors: C
authors: Li
authors: Yi
authors: Y
authors: Li
authors: Peng
authors: P
authors: Bai
authors: Wen-Liang
authors: WL
authors: Fang
authors: Hui
authors: H
authors: Xue
authors: Lin
authors: L
authors: Zhang
mesh_terms: D000328:Adult; D000483:Alleles; D001483:Base Sequence; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D017931:DNA Primers; D004815:Epidermal Growth Factor / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D017931:DNA Primers; D004815:Epidermal Growth Factor; D066246:ErbB Receptors