title: Involvement of an essential gene, mviN, in murein synthesis in Escherichia coli.
abstract: We isolated a temperature-sensitive mutant with a mutation in mviN, an essential gene in Escherichia coli. At the nonpermissive temperature, mviN mutant cells swelled and burst. An intermediate in murein synthesis, polyprenyl diphosphate-N-acetylmuramic acid-(pentapeptide)-N-acetyl-glucosamine, accumulated in mutant cells. These results indicated that MviN is involved in murein synthesis.
authors: Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Minamiohsawa, Hachioji, Tokyo 192-0397, Japan.
authors: Azusa
authors: A
authors: Inoue
authors: Yoshimitsu
authors: Y
authors: Murata
authors: Hiroshi
authors: H
authors: Takahashi
authors: Naoko
authors: N
authors: Tsuji
authors: Shingo
authors: S
authors: Fujisaki
authors: Jun-ichi
authors: J
authors: Kato
mesh_terms: D001483:Base Sequence; D002250:Carbon Radioisotopes; D003960:Diaminopimelic Acid / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D020043:Genes, Essential / Q000235:genetics; D045782:Hemiterpenes / Q000378:metabolism; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009154:Mutation; D009943:Organophosphorus Compounds / Q000378:metabolism; D010457:Peptidoglycan / Q000096:biosynthesis*; D013696:Temperature
chemical_list: D002250:Carbon Radioisotopes; D029968:Escherichia coli Proteins; D045782:Hemiterpenes; D009943:Organophosphorus Compounds; D010457:Peptidoglycan; C004809:isopentenyl pyrophosphate; D003960:Diaminopimelic Acid