Subthalamotomy in cervical dystonia: A case study of lesion location and clinical outcome.
Here we report a 63-year-old woman with primary cervical dystonia (CD) whose symptoms subsided for more than 30 years following a unilateral stereotactic subthalamotomy contralateral to the overactive left sternocleidomastoid muscle but then gradually recurred over a period of several months. The aim of the present study was to correlate the topography of the stereotactic lesion with the long lasting therapeutic effect. High-resolution magnetic resonance imaging and subsequent stereotactic analysis were performed to determine the anatomical localization of the lesion. The primary coagulation focus comprised the posterior subthalamic white matter in the prelemniscal radiation and field H of Forel. Neighboring structures were implicated to various extents. It is suggested that the posterior subthalamic area, with its abundance of interconnecting fibers and related nuclei, represents an effective target for the neurosurgical treatment of CD that may be explored further with deep brain stimulation.
Moll
Christian K E
CK
Department of Neurophysiology and Pathophysiology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. c.moll@uke.uni-hamburg.de
Hamel
Wolfgang
W
Ostertag
Christoph B
CB
Müller
Dieter
D
Finsterbusch
Jürgen
J
Engel
Andreas K
AK
Münchau
Alexander
A
D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009460:Neurologic Examination; D011184:Postoperative Period; D020530:Subthalamus / Q000601:surgery*; D014103:Torticollis / Q000473:pathology* / Q000601:surgery*