[Immunohistochemical evaluation of the distribution of vascular endothelial growth factor in the placenta, placental bed in normal pregnancy and in women with preeclampsia].
VEGF expression was immunohistochemically studied in 35 placental fragments and 15 placental bed biopsy specimens in a control group and in 34 placental fragments and 16 biopsy specimens in women with preeclampsia. The female serum concentrations of VEGF and sFlt-I were measured in both groups. There was a drastic reduction in VEGF expression in the placenta (syncytiotrophoblast, free symplasts, syncytial kidneys); the placental bed biopsy specimens showed the impaired rearrangement of maternal-placental arteries with the lower VEGF expression in the cytotrophoblastic cells from women with preeclampsia. The blood displayed a 10-fold reduction in VEGF along with a 3.5-fold increase in SFlt-1 concentrations. Deficiency of free (circulating) VEGF-A that is so essential for normal endothelial function is likely to cause its structural changes that are united under the term "endotheliosis" as one of the leading mechanisms of the pathogenesis of gestosis.
Milovanov
A P
AP
Sidorova
I S
IS
Solonitsyn
A N
AN
Borovkova
E I
EI
D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D011225:Pre-Eclampsia / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D014327:Trophoblasts / Q000378:metabolism* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000096:biosynthesis
D015415:Biomarkers; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1