title: Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-deficient mice.
abstract: PACAP is a neurotransmitter involved in the signal transduction of light stimulation in the suprachiasmatic nucleus (SCN). Light stimulation affects autonomic nerve activity via the SCN, and here we tested whether PACAP participates in light-induced regulation of sympatho-adrenal activity by using PACAP-deficient (Adcyap1(-/-)) mice. Light stimulation (100 lux, 30 min) significantly elevated both renal sympathetic nerve activity (RSNA), which was monitored on a digital oscilloscope, and plasma corticosterone levels in wild-type mice, but both responses were almost abolished in Adcyap1(-/-) mice. Although light-induced c-Fos expression in the SCN was observed in both genotypes, the numbers of c-Fos positive cells were significantly decreased in Adcyap1(-/-) mice. These data suggest that PACAP signaling pathway is involved in light-induced stimulation of RSNA and plasma corticosterone release through SCN of brain.
authors: Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
authors: Michiyoshi
authors: M
authors: Hatanaka
authors: Mamoru
authors: M
authors: Tanida
authors: Norihito
authors: N
authors: Shintani
authors: Yasushi
authors: Y
authors: Isojima
authors: Chihiro
authors: C
authors: Kawaguchi
authors: Hitoshi
authors: H
authors: Hashimoto
authors: Michiya
authors: M
authors: Kakuda
authors: Ryota
authors: R
authors: Haba
authors: Katsuya
authors: K
authors: Nagai
authors: Akemichi
authors: A
authors: Baba
mesh_terms: D000818:Animals; D001794:Blood Pressure; D003345:Corticosterone / Q000097:blood*; D007668:Kidney / Q000294:innervation*; D008027:Light; D051379:Mice; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D013493:Suprachiasmatic Nucleus / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000502:physiology*
chemical_list: C495402:Adcyap1 protein, mouse; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D016760:Proto-Oncogene Proteins c-fos; D003345:Corticosterone