The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival.
Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL.
Wang
Xiao
X
Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden.
Asplund
A Charlotta
AC
Porwit
Anna
A
Flygare
Jenny
J
Smith
C I Edvard
CI
Christensson
Birger
B
Sander
Birgitta
B
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002467:Cell Nucleus / Q000737:chemistry; D019938:Cyclin D1 / Q000235:genetics; D003593:Cytoplasm / Q000737:chemistry; D005260:Female; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D020522:Lymphoma, Mantle-Cell / Q000145:classification / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D055751:SOXC Transcription Factors / Q000235:genetics*; D015996:Survival Rate
D014408:Biomarkers, Tumor; C097473:SOX11 protein, human; D055751:SOXC Transcription Factors; D019938:Cyclin D1