title: Bovine pericardium in treating large corneal perforation secondary to alkali injury: a case report.
abstract: To describe use of a locally processed bovine pericardium (BP) to cover a large central corneal perforation following alkali injury and discuss postoperative outcome. A 27-year-old Malay male patient presented two weeks after alkali splashed in his left eye while working. A clinical diagnosis of left central corneal ulcer with limbal ischemia following alkali injury with secondary infection was made. After failed medical therapy, we performed a Gunderson conjunctival flap under local anesthesia that retracted after one week and resulted in a large central corneal perforation with surrounding stromal thinning. The perforation was covered with a locally processed BP xenograft (Lyolemb) supplied by the National Tissue Bank, University Sains Malaysia. Nine months follow-up showed a well-taken graft without any exposure/dehiscence and minimal inflammation. Amniotic membrane transplantation when used as a patch graft needs an urgent tectonic graft to promote corneal stability in patients with severe corneal thinning. The use of processed BP can be a viable option in treating such cases.
authors: Department of Ophthalmology, School of Medical Sciences, University Sains Malaysia, Malaysia. nidhirajeshkhanna@yahoo.com
authors: Rajesh K
authors: RK
authors: Khanna
authors: Ezanee
authors: E
authors: Mokhtar
mesh_terms: D000328:Adult; D000468:Alkalies / Q000009:adverse effects*; D000818:Animals; D002057:Burns, Chemical / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D002417:Cattle; D003315:Cornea / Q000187:drug effects / Q000601:surgery; D065306:Corneal Injuries; D005126:Eye Burns / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D010496:Pericardium / Q000637:transplantation*; D012421:Rupture; D014183:Transplantation, Heterologous; D015599:Trauma Severity Indices
chemical_list: D000468:Alkalies