title: [Case of serious renal failure induced by ingesting large volume of MAKIRON].
abstract: A 23-year-old male patient ingested 150 mL of MAKIRON in a suicide attempt and was transferred to the hospital emergency room approximately 30 hours after ingestion. Upon admission, components of MAKIRON, including naphazoline (1.4 microg/mL), chlorpheniramine (0.81 microg/mL), dibucaine (3.2 microg/mL) and benzethonium (5.5 microg/mL) were detected in the patient's plasma. Direct hemoperfusion and hemodiafiltration enforcement were carried out and the chemical components of MAKIRON were not detected the following day. At the time of hospitalization, the patient presented with serious hepatopathy, pneumonia and acute renal failure. The hepatopathy and pneumonia resolved several days later; however, the patient required continuation of dialysis three times per week for seventeen days due to persistence of anuria. Few case reports on renal failure induced by MAKIRON have been published, whereas there are occasional reports of MAKIRON poisoning. Serious renal dysfunction in this case is thought to be due to both the large volume of MAKIRON ingested and the time delay between ingestion and treatment.
authors: Department of Pharmacy, Toho University Omori Medical Center.
authors: Itsuka
authors: I
authors: Hanji
authors: Kazuhiro
authors: K
authors: Matsuo
authors: Itsuki
authors: I
authors: Kimura
authors: Takayoshi
authors: T
authors: Kosugi
authors: Mirei
authors: M
authors: Saito
authors: Katsunori
authors: K
authors: Yoshihara
authors: Noriko
authors: N
authors: Suga
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000328:Adult; D004202:Disinfectants / Q000097:blood / Q000737:chemistry / Q000506:poisoning*; D017583:Hemodiafiltration; D015312:Hemodialysis Solutions; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D017236:Suicide, Assisted; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D004202:Disinfectants; D015312:Hemodialysis Solutions