title: Genetic analysis of interleukin-1A C(-889)T polymorphism with Alzheimer disease.
abstract: Neuroinflammation has been implicated in the etiology of Alzheimer's disease (AD). Many studies have suggested that C(-889) T promoter polymorphism in one of the proinflammatory cytokine interleukin-1 (IL-1) encoding gene IL-1A may be associated with AD pathogenesis. To determine whether the polymorphism contributes to the risk for late-onset AD (LOAD) in Chinese, we carried out our investigation in 344 sporadic LOAD patients and 224 healthy controls. No statistical significant association was obtained between IL-1A C(-889) T polymorphism and LOAD and no statistical difference was found between cases and controls after stratification for apolipoprotein E allele 4 (APOE epsilon4) status. The results reveal that it is not likely that the IL-1A C(-889) T polymorphism is involved in AD pathogenesis in the Chinese population. Further studies of the associations between other IL-1A genetic polymorphisms and AD should be performed in a larger population and biologic functional analysis of IL-1A gene is required to verify the underlying roles of IL-IA in LOAD.
authors: Neurosurgery Department, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Neurosurgery Institute, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou, China.
authors: Ji-Liang
authors: JL
authors: Hu
authors: Gang
authors: G
authors: Li
authors: De-Xiang
authors: DX
authors: Zhou
authors: Yu-Xi
authors: YX
authors: Zou
authors: Zhi-Shan
authors: ZS
authors: Zhu
authors: Ru-Xiang
authors: RX
authors: Xu
authors: Xiao-Dan
authors: XD
authors: Jiang
authors: Yan-Jun
authors: YJ
authors: Zeng
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D053582:Interleukin-1alpha