Aspirin intake suppresses MMC-induced genotoxicity in mice.
The genotoxicity induced by mitomycin C (MMC) was found to be decreased by aspirin on alkaline single cell gel electrophoresis (SCG) assay in multiple organs of mice. Aspirin at doses of 0.5, 5 and 50 mg/kg and MMC at 2 mg/kg were administered and then liver, lung, kidney, spleen, colon and bone marrow were sampled after 3 h. Significant protective effects of aspirin against MMC-induced genotoxicity was observed in all but the bone marrow, where no change was evident. The results suggest that the radical scavenging ability of aspirin prevents danage by MMC-induced reactive oxygen species (ROS) in multiple organs.
Niikawa
Miki
M
Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan. niikawam@tim.hi-ho.ne.jp
Okamura
Tetsunori
T
Sugiura
Katsunori
K
Nagase
Hisamitsu
H
D000477:Alkylating Agents / Q000633:toxicity*; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001853:Bone Marrow / Q000187:drug effects; D003106:Colon / Q000187:drug effects; D020552:Comet Assay; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004249:DNA Damage; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D016685:Mitomycin / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects
D000477:Alkylating Agents; D016861:Cyclooxygenase Inhibitors; D016685:Mitomycin; D001241:Aspirin