title: Electron tomography shows molecular anchoring within a layer-by-layer film.
abstract: The layer-by-layer self-assembly of thin films consisting of alternating layers of DNA and bis-urea nanoribbons prevents diffusion of the components within the film and allows the anchoring of biotinylated molecules through molecular recognition in a predetermined layer of the film. Electron tomography demonstrates with nanometer precision the location of gold-labeled streptavidin bound to the incorporated biotinylated molecules.
authors: Soft Matter Cryo-TEM Research Unit, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
authors: Matthijn R J
authors: MR
authors: Vos
authors: Monica
authors: M
authors: Breurken
authors: Philippe E L G
authors: PE
authors: Leclère
authors: Paul H H
authors: PH
authors: Bomans
authors: Felix
authors: F
authors: de Haas
authors: Peter M
authors: PM
authors: Frederik
authors: John A
authors: JA
authors: Jansen
authors: Roeland J M
authors: RJ
authors: Nolte
authors: Nico A J M
authors: NA
authors: Sommerdijk
mesh_terms: D001710:Biotin / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D055032:Electron Microscope Tomography / Q000379:methods; D049329:Nanostructures / Q000737:chemistry*; D019809:Streptavidin / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D014508:Urea / Q000737:chemistry*
chemical_list: D013501:Surface-Active Agents; D001710:Biotin; D014508:Urea; D004247:DNA; D019809:Streptavidin