title: Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: a Children's Oncology Group phase I study.
abstract: The purpose of this study was to determine the dose-limiting toxicities, maximum tolerated dose, pharmacokinetics, and intratumor and brain distribution of motexafin gadolinium (MGd) with involved field radiation therapy in children with newly diagnosed intrinsic pontine gliomas. MGd was administered as a 5-min intravenous bolus 2-5 h prior to standard radiation. The starting dose was 1.7 mg/kg. After first establishing that 5 doses/week for 6 weeks was tolerable, the dose of MGd was escalated until dose-limiting toxicity was reached. Radiation therapy was administered to 54 Gy in 30 once-daily fractions. Forty-four children received MGd at doses of 1.7 to 9.2 mg/kg daily prior to radiation therapy for 6 weeks. The maximum tolerated dose was 4.4 mg/kg. The primary dose-limiting toxicities were grade 3 and 4 hypertension and elevations in serum transaminases. Median elimination half-life and clearance values were 6.6 h and 25.4 ml/kg/h, respectively. The estimated median survival was 313 days (95% confidence interval, 248-389 days). The maximum tolerated dose of MGd and the recommended phase II dose was 4.4 mg/kg when administered as a daily intravenous bolus in conjunction with 6 weeks of involved field radiation therapy for pediatric intrinsic pontine gliomas.
authors: University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
authors: Kristin A
authors: KA
authors: Bradley
authors: Ian F
authors: IF
authors: Pollack
authors: Joel M
authors: JM
authors: Reid
authors: Peter C
authors: PC
authors: Adamson
authors: Matthew M
authors: MM
authors: Ames
authors: Gilbert
authors: G
authors: Vezina
authors: Susan
authors: S
authors: Blaney
authors: Percy
authors: P
authors: Ivy
authors: Tianni
authors: T
authors: Zhou
authors: Mark
authors: M
authors: Krailo
authors: Gregory
authors: G
authors: Reaman
authors: Minesh P
authors: MP
authors: Mehta
mesh_terms: D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D020295:Brain Stem Neoplasms / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005910:Glioma / Q000628:therapy*; D006207:Half-Life; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020714:Maximum Tolerated Dose; D008665:Metalloporphyrins / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D011149:Pons / Q000473:pathology*; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D011878:Radiotherapy
chemical_list: D008665:Metalloporphyrins; D011838:Radiation-Sensitizing Agents; C437683:motexafin gadolinium