[Etanercept as a possible trigger of fatal pulmonary fibrosis].
Pulmonary fibrosis can be caused by external agents, including certain drugs. For some time now, tumor necrosis factor antagonists such as etanercept have been used to treat certain autoimmune diseases. Fibrosis caused by medication responds to withdrawal of the drug and treatment with corticosteroids. Very rarely, fibrosis is irreversible. We present the case of a patient who developed pulmonary fibrosis after initiating treatment with etanercept. The clinical course was fulminant despite withdrawal of the drug and high doses of corticosteroids.
Díez Piña
Juan M
JM
Servicio de Neumología, Hospital de Móstoles, Móstoles, Madrid, Spain. jmdpas@hotmail.com
Vázquez Gómez
Oscar
O
Mayoralas Alises
Sagrario
S
García Jiménez
José D
JD
Alvaro Alvarez
Dolores
D
Rodríguez Bolado
M Paz
MP
D000328:Adult; D000068800:Etanercept; D017809:Fatal Outcome; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects*; D008297:Male; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D000068800:Etanercept