[Process of platelets activation by streptokinase].
This study concerns the influence of streptokinase and antistreptokinase antibodies on rabbits platelets in blood plasma depleted of plasminogen. The immune complex streptokinase-antibody causes platelets activation, whereas other investigated immune complexes didnot express such activity. Platelets aggregation wasnot detected in any case. It was determined that streptokinase induces platelets activation in the rabbit plasma with high titre of antistreptokinase antibodies in absence of plasminogen.
Burlova-Vasyl'ieva
N K
NK
Krasnobryzha
Ie M
IeM
Savchuk
O M
OM
Volkov
H L
HL
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D000936:Antigen-Antibody Complex / Q000276:immunology; D002478:Cells, Cultured; D010958:Plasminogen / Q000378:metabolism; D015539:Platelet Activation / Q000187:drug effects* / Q000276:immunology; D010974:Platelet Aggregation / Q000187:drug effects / Q000276:immunology; D011817:Rabbits; D013300:Streptokinase / Q000276:immunology / Q000494:pharmacology*
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D010958:Plasminogen; D013300:Streptokinase