title: Cellular functions of cardiolipin in yeast.
abstract: Cardiolipin (CL), the signature lipid of mitochondria, plays a critical role in mitochondrial function and biogenesis. The availability of yeast mutants blocked in CL synthesis has facilitated studies of the biological role of this lipid. Perturbation of CL synthesis leads to growth defects not only during respiratory growth but also under conditions in which respiration is not essential. CL was shown to play a role in mitochondrial protein import, cell wall biogenesis, aging and apoptosis, ceramide synthesis, and translation of electron transport chain components. The genetic disorder Barth syndrome (BTHS) is caused by mutations in the tafazzin gene resulting in decreased total CL levels, accumulation of monolysocardiolipin (MLCL), and decreased unsaturated fatty acyl species of CL. The variation in clinical presentation of BTHS indicates that other physiological factors play a significant role in modifying the phenotype resulting from tafazzin deficiency. Elucidating the functions of CL is expected to shed light on the role of this important lipid in BTHS and other disorders of mitochondrial dysfunction.
authors: Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA.
authors: Amit S
authors: AS
authors: Joshi
authors: Jingming
authors: J
authors: Zhou
authors: Vishal M
authors: VM
authors: Gohil
authors: Shuliang
authors: S
authors: Chen
authors: Miriam L
authors: ML
authors: Greenberg
mesh_terms: D000217:Acyltransferases; D017209:Apoptosis; D002308:Cardiolipins / Q000378:metabolism*; D016922:Cellular Senescence; D004579:Electron Transport / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism; D028361:Mitochondrial Diseases / Q000378:metabolism; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D002308:Cardiolipins; D014157:Transcription Factors; D000217:Acyltransferases; C108675:TAFAZZIN protein, human