title: [Assessment of systane in severe dry eye].
abstract: The study proposes the evaluation of the Systane effect on people that have severe dry eye sensation, with cornea or conjunctive complications. In order to do this, a study protocol has been adopted which meant comparing the values of lacrimal film break-up time, before and after Systane treatment, comparing cornea and conjunctive staining, comparing the crystallization test before and after treatment, comparing the conjunctival impression before and after treatment, and the general acceptability of Systane. The study results have shown that in severe dry eye cases, Systane increases lacrimal film break-up time by 2-3 seconds than the initial value, as well as considerable reduction in cornea/conjunctival staining and in conjunctival hyperemia in Sicca keratoconjunctivitis. After treatment, conjunctival impression have shown the proliferation of conjunctival and goblet cells, with normal morphologic aspect of the new-formed cells. In every case, the regenerating effect on epithelia of Systane was obvious, which is determined by the direct action of the HP-guar, forming a protective layer with lubrication effect, helpful to the initiation of tissue repairing processes.
authors: Clinica de Oftalmologie Craiova.
authors: Carmen
authors: C
authors: Mocanu
authors: Doina
authors: D
authors: Bărăscu
authors: Flori
authors: F
authors: Bîrjovanu
authors: Rodica
authors: R
authors: Mănescu
authors: Felicia
authors: F
authors: Iliuşi
mesh_terms: D000368:Aged; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007638:Keratoconjunctivitis Sicca / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage* / Q000737:chemistry; D014677:Pharmaceutical Vehicles / Q000008:administration & dosage; D011092:Polyethylene Glycols / Q000008:administration & dosage; D019946:Propylene Glycol / Q000008:administration & dosage; D012383:Romania; D013501:Surface-Active Agents / Q000008:administration & dosage; D011795:Surveys and Questionnaires; D013666:Tears / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; D019946:Propylene Glycol