Expression of PCNA and bcl-2 in basaloid squamous cell carcinoma of the larynx: a controlled study.
We investigated the difference in the biologic nature of typical squamous cell carcinoma (SCC) and basaloid SCC (BSCC) of the larynx by studying proliferation and antiapoptotic markers. We performed an immunohistochemical analysis of the expression of proliferating cell nuclear antigen (PCNA) and bcl-2 protein in 15 patients with laryngeal BSCC and 15 stage- and site-matched controls with typical laryngeal SCC. We found no significant difference between the two groups in the PCNA index or the frequency of bcl-2 overexpression, nor did we find any significant difference in survival. Our findings indicate that the biologic nature of typical laryngeal SCC and laryngeal BSCC is similar. In addition, our follow-up data suggest that the clinical course of laryngeal BSCC is no worse than that of typical laryngeal SCC.
Deniz
Kemal
K
Department of Pathology, Erciyes University Faculty of Medicine, 38039 Kayseri, Turkey. drkdeniz@yahoo.com
Yüce
Imdat
I
Cağli
Sedat
S
Okten
Turhan
T
Güney
Ercihan
E
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D002281:Carcinoma, Basosquamous / Q000276:immunology / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology*; D016022:Case-Control Studies; D019254:Genes, bcl-2; D006801:Humans; D007822:Laryngeal Neoplasms / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D018809:Proliferating Cell Nuclear Antigen