title: Chemokine decoy receptors: new players in reproductive immunology.
abstract: Chemokines are multifunctional molecules with roles in leukocyte trafficking and developmental processes. Both fetal and maternal components of the placenta produce chemokines, which control leukocyte trafficking observed in the placenta. Thus, chemokines play roles in the balance between protection of the developing embryo/fetus and tolerance of its hemiallogeneic tissues. Recently, a group of chemokine receptors, which include D6, DARC, and CCX-CKR, have been described as "silent" receptors by virtue of their inability to activate signal transduction events leading to cell chemoattraction. Here we review in vitro and in vivo evidence indicating that chemokine "silent" receptors regulate innate and adaptive immunity behaving as decoy receptors that support internalization and degradation of chemotactic factors, and discuss available information on their potential role in reproductive immunology.
authors: Istituto Clinico Humanitas IRCCS, Rozzano, Italy.
authors: Elena Monica
authors: EM
authors: Borroni
authors: Raffaella
authors: R
authors: Bonecchi
authors: Chiara
authors: C
authors: Buracchi
authors: Benedetta
authors: B
authors: Savino
authors: Alberto
authors: A
authors: Mantovani
authors: Massimo
authors: M
authors: Locati
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D018925:Chemokines / Q000819:agonists / Q000276:immunology / Q000378:metabolism; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D004375:Duffy Blood-Group System / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000276:immunology* / Q000378:metabolism; D010920:Placenta / Q000276:immunology / Q000378:metabolism; D021041:Placental Circulation / Q000276:immunology*; D011247:Pregnancy / Q000276:immunology*; D054447:Receptors, CCR10 / Q000819:agonists / Q000276:immunology* / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000819:agonists / Q000276:immunology* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000276:immunology* / Q000378:metabolism; D018456:Reproductive Medicine; D015398:Signal Transduction / Q000276:immunology; D000097628:Chemokine Receptor D6
chemical_list: D018925:Chemokines; D004375:Duffy Blood-Group System; D054447:Receptors, CCR10; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D000097628:Chemokine Receptor D6; C473745:ACKR1 protein, human; C091671:XCR1 protein, human