title: Enantioselective synthesis of the fully functionalized ABC ring of zoanthenol.
abstract: Zoanthenol, isolated from Zoanthus sp., possesses an extremely complex architecture including contiguous quaternary carbons. An enantioselective synthesis of the fully functionalized ABC-ring of zoanthenol has been achieved and is described herein. The key features of the synthesis are the enzymatic kinetic optical resolution and the Mizoroki-Heck/Simmons-Smith reaction strategy used to construct the congested asymmetric quaternary carbons.
authors: Department of Chemistry, Graduate School of Science, Tohoku University, Aramaki-aza Aoba, Aoba-ku, Sendai, Miyagi, Japan.
authors: Naoki
authors: N
authors: Sugano
authors: Yuuki
authors: Y
authors: Koizumi
authors: Go
authors: G
authors: Hirai
authors: Hiroki
authors: H
authors: Oguri
authors: Shoji
authors: S
authors: Kobayashi
authors: Shuji
authors: S
authors: Yamashita
authors: Masahiro
authors: M
authors: Hirama
mesh_terms: D000470:Alkaloids / Q000737:chemistry; D006572:Heterocyclic Compounds, Bridged-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D006572:Heterocyclic Compounds, Bridged-Ring; C457061:zoanthenol