Altered T and B lymphocyte signaling pathways in lupus.
Systemic lupus erythematosus (SLE) has long been recognized to be characterized by dysregulated signaling pathways in T and B lymphocytes, beginning with observations of cellular hyperactivity and hyperresponsiveness, and evolving to recent studies focused upon the genetic and molecular bases of such phenomena. This review focuses on recently elucidated signaling abnormalities currently thought to be intrinsic to T and/or B cells in human SLE.
Peng
Stanford L
SL
Clinical Research and Exploratory Development, 3431 Hillview Ave., M/S A2-259, Palo Alto, CA 94304, USA. stanford.peng@roche.com
D017398:Alternative Splicing / Q000276:immunology; D000818:Animals; D015703:Antigens, CD / Q000276:immunology* / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D017252:CD3 Complex / Q000276:immunology* / Q000378:metabolism; D019175:DNA Methylation / Q000235:genetics / Q000276:immunology; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000378:metabolism*; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology*; D021962:Membrane Microdomains / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
D015703:Antigens, CD; D017252:CD3 Complex; C121704:CD3 antigen, zeta chain; D004268:DNA-Binding Proteins; D020662:Guanine Nucleotide Exchange Factors; D007376:Interleukin-2; C491790:RASGRP1 protein, human; D011948:Receptors, Antigen, T-Cell