title: Alkali metal reductions of organic molecules: why mediated electron transfer from lithium is faster than direct reduction.
abstract: Lithium metal reductions are widely employed in organic synthesis, where it is common to employ a "mediator" to speed up the electron transfer kinetics. We present experimental data for the electrode kinetics of the reduction of the most common mediator, 4,4'-di-tert-butyl-1,1'-biphenyl (DBB) in tetrahydrofuran (THF) over a range of temperatures. Using corresponding data for the oxidation of lithium we present quantitative estimates of the kinetic advantage for the use of DBB as a mediator in lithium reductions, over, in particular, direct reduction using lithium metal.
authors: Department of Chemistry, Physical and Theoretical Chemistry Laboratory, Oxford University, South Parks Road, Oxford, OX1 3QZ, UK.
authors: Neil V
authors: NV
authors: Rees
authors: Ronan
authors: R
authors: Baron
authors: Neil M
authors: NM
authors: Kershaw
authors: Timothy J
authors: TJ
authors: Donohoe
authors: Richard G
authors: RG
authors: Compton