PNA/DNA interstrand cross-links from a modified PNA base upon photolysis or oxidative conditions.
PNA/DNA interstrand cross-links (ICLs) were observed when peptide nucleic acids (PNAs) containing modified thymine derivatives were hybridized with the complementary or one-base mismatched DNA upon photolysis or treatments of oxidative agent. PNA/DNA ICL formation provides a useful method for biological applications such as antisense technologies or PNA chips.
Kim
Yongtae
Y
Department of Chemistry, College of Natural Science, Kongju National University, 182 Shinkwan-dong, Kongju, Chungnam 314-701, Republic of Korea.
Hong
In Seok
IS
D003432:Cross-Linking Reagents; D004247:DNA / Q000378:metabolism*; D016373:DNA, Antisense / Q000032:analysis; D015394:Molecular Structure; D010084:Oxidation-Reduction; D020135:Peptide Nucleic Acids / Q000378:metabolism*; D010782:Photolysis; D013941:Thymine / Q000031:analogs & derivatives / Q000737:chemistry
D003432:Cross-Linking Reagents; D016373:DNA, Antisense; D020135:Peptide Nucleic Acids; D004247:DNA; D013941:Thymine