Genetic analysis of interleukin-1A C(-889)T polymorphism with Alzheimer disease.
Neuroinflammation has been implicated in the etiology of Alzheimer's disease (AD). Many studies have suggested that C(-889) T promoter polymorphism in one of the proinflammatory cytokine interleukin-1 (IL-1) encoding gene IL-1A may be associated with AD pathogenesis. To determine whether the polymorphism contributes to the risk for late-onset AD (LOAD) in Chinese, we carried out our investigation in 344 sporadic LOAD patients and 224 healthy controls. No statistical significant association was obtained between IL-1A C(-889) T polymorphism and LOAD and no statistical difference was found between cases and controls after stratification for apolipoprotein E allele 4 (APOE epsilon4) status. The results reveal that it is not likely that the IL-1A C(-889) T polymorphism is involved in AD pathogenesis in the Chinese population. Further studies of the associations between other IL-1A genetic polymorphisms and AD should be performed in a larger population and biologic functional analysis of IL-1A gene is required to verify the underlying roles of IL-IA in LOAD.
Hu
Ji-Liang
JL
Neurosurgery Department, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Neurosurgery Institute, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Li
Gang
G
Zhou
De-Xiang
DX
Zou
Yu-Xi
YX
Zhu
Zhi-Shan
ZS
Xu
Ru-Xiang
RX
Jiang
Xiao-Dan
XD
Zeng
Yan-Jun
YJ
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D053582:Interleukin-1alpha