title: Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
abstract: To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
authors: Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
authors: Manuel A R
authors: MA
authors: Ferreira
authors: Michael C
authors: MC
authors: O'Donovan
authors: Yan A
authors: YA
authors: Meng
authors: Ian R
authors: IR
authors: Jones
authors: Douglas M
authors: DM
authors: Ruderfer
authors: Lisa
authors: L
authors: Jones
authors: Jinbo
authors: J
authors: Fan
authors: George
authors: G
authors: Kirov
authors: Roy H
authors: RH
authors: Perlis
authors: Elaine K
authors: EK
authors: Green
authors: Jordan W
authors: JW
authors: Smoller
authors: Detelina
authors: D
authors: Grozeva
authors: Jennifer
authors: J
authors: Stone
authors: Ivan
authors: I
authors: Nikolov
authors: Kimberly
authors: K
authors: Chambert
authors: Marian L
authors: ML
authors: Hamshere
authors: Vishwajit L
authors: VL
authors: Nimgaonkar
authors: Valentina
authors: V
authors: Moskvina
authors: Michael E
authors: ME
authors: Thase
authors: Sian
authors: S
authors: Caesar
authors: Gary S
authors: GS
authors: Sachs
authors: Jennifer
authors: J
authors: Franklin
authors: Katherine
authors: K
authors: Gordon-Smith
authors: Kristin G
authors: KG
authors: Ardlie
authors: Stacey B
authors: SB
authors: Gabriel
authors: Christine
authors: C
authors: Fraser
authors: Brendan
authors: B
authors: Blumenstiel
authors: Matthew
authors: M
authors: Defelice
authors: Gerome
authors: G
authors: Breen
authors: Michael
authors: M
authors: Gill
authors: Derek W
authors: DW
authors: Morris
authors: Amanda
authors: A
authors: Elkin
authors: Walter J
authors: WJ
authors: Muir
authors: Kevin A
authors: KA
authors: McGhee
authors: Richard
authors: R
authors: Williamson
authors: Donald J
authors: DJ
authors: MacIntyre
authors: Alan W
authors: AW
authors: MacLean
authors: Clair David
authors: CD
authors: St
authors: Michelle
authors: M
authors: Robinson
authors: Margaret
authors: M
authors: Van Beck
authors: Ana C P
authors: AC
authors: Pereira
authors: Radhika
authors: R
authors: Kandaswamy
authors: Andrew
authors: A
authors: McQuillin
authors: David A
authors: DA
authors: Collier
authors: Nicholas J
authors: NJ
authors: Bass
authors: Allan H
authors: AH
authors: Young
authors: Jacob
authors: J
authors: Lawrence
authors: I Nicol
authors: IN
authors: Ferrier
authors: Adebayo
authors: A
authors: Anjorin
authors: Anne
authors: A
authors: Farmer
authors: David
authors: D
authors: Curtis
authors: Edward M
authors: EM
authors: Scolnick
authors: Peter
authors: P
authors: McGuffin
authors: Mark J
authors: MJ
authors: Daly
authors: Aiden P
authors: AP
authors: Corvin
authors: Peter A
authors: PA
authors: Holmans
authors: Douglas H
authors: DH
authors: Blackwood
authors: Hugh M
authors: HM
authors: Gurling
authors: Michael J
authors: MJ
authors: Owen
authors: Shaun M
authors: SM
authors: Purcell
authors: Pamela
authors: P
authors: Sklar
authors: Nick
authors: N
authors: Craddock
mesh_terms: D017487:Ankyrins / Q000235:genetics*; D001714:Bipolar Disorder / Q000235:genetics*; D020746:Calcium Channels, L-Type / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10; D002881:Chromosomes, Human, Pair 12; D002884:Chromosomes, Human, Pair 15; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D016015:Logistic Models; D020641:Polymorphism, Single Nucleotide
chemical_list: C490613:ANK3 protein, human; D017487:Ankyrins; C079146:CACNA1C protein, human; D020746:Calcium Channels, L-Type