No relationship between plasma desacyl-ghrelin levels and rabeprazole-related delay in gastric emptying : controlled study in healthy volunteers.
OBJECTIVE
Recent studies have indicated that rabeprazole, a proton pump inhibitor, delays gastric emptying. However, the mechanism of action remains unclear. We conducted this study to clarify whether desacyl-ghrelin (the inactive form of the endogenous growth hormone secretagogue receptor ghrelin) is involved in rabeprazole-induced changes in gastric motor function.


METHODS
Twelve healthy males underwent (13)C-acetate breath tests to evaluate gastric emptying of a liquid meal twice after administration of rabeprazole 20 mg/day for 3 days or no medication (control). Gastric emptying was evaluated by two parameters: half-emptying time and time to peak (13)CO(2) excretion. Plasma desacyl-ghrelin levels were measured in blood samples collected at three time points: immediately pre-test and 1 and 2 hours after ingestion of the test meal.


RESULTS
Rabeprazole significantly delayed gastric emptying of the liquid meal. However, plasma desacyl-ghrelin levels after ingestion of the liquid meal showed little difference before or after rabeprazole administration.


CONCLUSIONS
The results indicate that desacyl-ghrelin was not associated with changes in gastric emptying caused by rabeprazole.
Yamamoto
Takatsugu
T
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan. ymmt@med.teikyo-u.ac.jp
Sanaka
Masaki
M
Anjiki
Hajime
H
Hattori
Kengo
K
Ishii
Taro
T
Kuyama
Yasushi
Y
D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000328:Adult; D001944:Breath Tests / Q000379:methods; D002245:Carbon Dioxide / Q000032:analysis / Q000378:metabolism; D002247:Carbon Isotopes; D005746:Gastric Emptying / Q000187:drug effects* / Q000502:physiology; D005755:Gastrins / Q000097:blood / Q000737:chemistry; D054439:Ghrelin / Q000097:blood* / Q000737:chemistry; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D064750:Rabeprazole; D018709:Statistics, Nonparametric
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D002247:Carbon Isotopes; D005755:Gastrins; D054439:Ghrelin; D054328:Proton Pump Inhibitors; C422650:ghrelin, des-n-octanoyl; D002245:Carbon Dioxide; D064750:Rabeprazole