title: Controlled release solid dosage forms using combinations of (meth)acrylate copolymers.
abstract: Controlled release solid oral dosage forms have been widely used for decades, enabling drugs to be administered more comfortably while at the same time providing a sustained and reproducible method of release. (Meth)acrylate copolymers are one of the options available when considering a sustained release solid form. Due to their different functionalities it is possible to achieve various different release profiles. The electrical character of these copolymers and their pH-dependent solubility can result in new and modified patterns when these polymers are combined. This review sheds light on various studies involving combinations of (meth)acrylate copolymers for use in multi-unit systems and matrix tablets, and also on several analytical methods that help to identify possible interactions between these polymers.
authors: EVONIK Industries, Pharma Polymers, Kirschenallee, Darmstadt, Germany. diego.gallardo@evonik.com
authors: Diego
authors: D
authors: Gallardo
authors: Brigitte
authors: B
authors: Skalsky
authors: Peter
authors: P
authors: Kleinebudde
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012995:Solubility; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer