title: Occurrence of trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a patient with B-cell chronic lymphocytic leukemia.
abstract: Trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) were found in a 59-year-old man with B-cell chronic lymphocytic leukemia (CLL). While trisomy 12 is one of the most common cytogenetic abnormalities in chronic lymphocytic leukemia, the t(14;18) rearrangement has a strong association with follicular lymphoma and the t(8;14) is associated with T-cell neoplasia. Occurrence of these three abnormalities in CLL are rare, and the significance of this finding is unclear. Further studies of similar cases may shed additional insight into this finding.
authors: Department of Pathology, Singapore General Hospital, Outram Road, Singapore. lau.lai.ching@sgh.com.sg
authors: Lai-Ching
authors: LC
authors: Lau
authors: Ping
authors: P
authors: Lim
authors: Yik-Chen
authors: YC
authors: Lim
authors: Li-Min
authors: LM
authors: Teng
authors: Tse-Hui
authors: TH
authors: Lim
authors: Lay-Cheng
authors: LC
authors: Lim
authors: Soo-Yong
authors: SY
authors: Tan
authors: Soon-Tiong
authors: ST
authors: Lim
authors: Warren G
authors: WG
authors: Sanger
authors: Sim-Leng
authors: SL
authors: Tien
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005434:Flow Cytometry; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic; D014314:Trisomy