title: Antiviral, antibacterial and vitamin C-synergized radical-scavenging activity of Sasa senanensis Rehder extract.
abstract: Sasa senanensis Rehder extract (SE) showed slightly higher cytotoxicity against human squamous cell carcinoma cell lines and human glioblastoma cell lines, as compared with human oral normal cells (gingival fibroblast, pulp cell, periodontal ligament fibroblast), and was more cytotoxic to human myelogenous and T-cell leukemia cell lines. SE showed a bacteriostatic effect on Fusobacterium nucleatum and Prevotella intermedia, but almost completely eliminated hydrogen sulfide (H2S) and methyl mercaptan (CH3SH) produced by these bacteria. SE protected human T-cell leukemia MT-4 cells from the cytopathic effect of human immunodeficiency virus (HIV) infection, and its anti-HIV activity was much higher than that of tannins and flavonoids, comparable with that of natural and synthetic lignins. SE also protected the MDCK cells from the cytopathic effect of influenza virus infection. SE synergistically enhanced the superoxide anion and hydroxyl radical-scavenging activity of vitamin C. The present study suggests the functionality of SE as a complementary alternative medicine.
authors: Meikai Pharmaco-Medical Laboratory, Meikai University School of Dentistry, Sakado, Saitama, Japan. sakagami@dent.meikai.ac.jp
authors: Hiroshi
authors: H
authors: Sakagami
authors: Shigeru
authors: S
authors: Amano
authors: Hirotaka
authors: H
authors: Kikuchi
authors: Yukio
authors: Y
authors: Nakamura
authors: Reina
authors: R
authors: Kuroshita
authors: Shigeru
authors: S
authors: Watanabe
authors: Kazue
authors: K
authors: Satoh
authors: Hideo
authors: H
authors: Hasegawa
authors: Akiko
authors: A
authors: Nomura
authors: Taisei
authors: T
authors: Kanamoto
authors: Shigemi
authors: S
authors: Terakubo
authors: Hideki
authors: H
authors: Nakashima
authors: Sumiko
authors: S
authors: Taniguchi
authors: Takaaki
authors: T
authors: Oizumi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019380:Anti-HIV Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism* / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D004285:Dogs; D004357:Drug Synergism; D005347:Fibroblasts / Q000378:metabolism; D016166:Free Radical Scavengers / Q000494:pharmacology; D015658:HIV Infections / Q000517:prevention & control; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D031787:Sasa / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D000998:Antiviral Agents; D016166:Free Radical Scavengers; D010936:Plant Extracts; D001205:Ascorbic Acid