title: Synthesis and antiprotozoal evaluation of new N4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones).
abstract: The synthesis and in-vitro antiprotozoal evaluation of novel N(4)-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thione) (bis-THTT) derivatives from N(4)-(benzyl)spermidine is disclosed. Several of the new bis-THTT have in-vitro activities against L. donovani and T. cruzi that are comparable or superior to those of currently employed protozoocidal agents.
authors: Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, Habana, Cuba.
authors: Julieta
authors: J
authors: Coro
authors: Susan
authors: S
authors: Little
authors: Vanessa
authors: V
authors: Yardley
authors: Margarita
authors: M
authors: Suárez
authors: Hortensia
authors: H
authors: Rodríguez
authors: Nazario
authors: N
authors: Martín
authors: Rolando
authors: R
authors: Perez-Pineiro
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D007893:Leishmania donovani / Q000187:drug effects; D013095:Spermidine / Q000737:chemistry; D013329:Structure-Activity Relationship; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D000981:Antiprotozoal Agents; D013871:Thiones; D013095:Spermidine