Psychopathological features of obsessive-compulsive disorder in an Italian family with Gilles de la Tourette syndrome not linked to the SLITRK1 gene.
We report the psychopathological features in a large Italian family with Gilles de la Tourette syndrome not linked to the SLITRK1 gene. Of the 23 living family members, 14 were evaluated using the Structured Clinical Interview for DSM-IV, the Yale-Brown Obsessive-Compulsive Scale, the Clinical Global Impression and the Global Assessment of Functioning scale. Ten patients were found to have obsessive-compulsive disorder in which tic-like compulsions predominated. The distinctive feature of this family is the high frequency of obsessive-compulsive disorder with various clinical phenotypes.
Pasquini
Massimo
M
Department of Psychiatric Science and Psychological Medicine, Sapienza University of Rome, Rome, Italy. massimo.pasquini@uniroma1.it
Fabbrini
Giovanni
G
Berardelli
Isabella
I
Bonifati
Vincenzo
V
Biondi
Massimo
M
Berardelli
Alfredo
A
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007558:Italy; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*; D010552:Personality Assessment / Q000706:statistics & numerical data; D010641:Phenotype; D011594:Psychometrics; D011599:Psychopathology; D005879:Tourette Syndrome / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*; D055815:Young Adult
D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C505093:SLITRK1 protein, human