Disposition kinetics and urinary excretion of ciprofloxacin in goats following single intravenous administration.
We evaluated the pharmacokinetics of ciprofloxacin in serum (n = 6) and urine (n = 4) in goats following a single intravenous administration of 4 mg/kg body weight. The serum concentration-time curves of ciprofloxacin were best fitted by a two-compartment open model. The drug was detected in goat serum up to 12 h. The elimination rate constant (beta) and elimination half-life (t1/2beta) were 0.446 +/- 0.04 h(-1) and 1.630 +/- 0.17 h, espectively. The apparent volume of distribution at steady state (Vdss) was 2.012 +/- 0.37 l/kg and the total body clearance (ClB) was 16.27 +/- 1.87 ml/min/kg. Urinary recovery of ciprofloxacin was 29.70% +/- 10.34% of the administered dose within 36 h post administration. In vitro serum protein binding was 41% +/- 13.10%. Thus, a single daily intravenous dose of 4 mg/kg is sufficient to maintain effective levels in serum and for 36 h in urine, allowing treatment of systemic, Gram-negative bacterial infections and urinary tract infections by most pathogens.
Raina
R
R
Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, She-e-Kasmir University of Agricultural Sciences and Technology of Jammu, Jammu 181102, India.
Prawez
S
S
Dimitrova
D J
DJ
Pankaj
N K
NK
Verma
P K
PK
D000818:Animals; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000652:urine*; D006041:Goats; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007275:Injections, Intravenous; D007601:Jugular Veins; D007700:Kinetics; D011485:Protein Binding
D002939:Ciprofloxacin