Catalytic enantioselective Reformatsky reaction with ortho-substituted diarylketones.
The catalytic enantioselective Reformatsky reaction with ortho-substituted diarylketones with good enantioselectivities and moderate to good yields is reported. A readily available BINOL derivative is used as a chiral catalyst, and the reactions are performed with ethyl iodoacetate as a nucleophile and Me2Zn as the zinc source. The presence of air was found to be crucial to achieve an effective C-C bond formation pointing to a radical mechanism.
Fernández-Ibáñez
M Angeles
MA
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Maciá
Beatriz
B
Minnaard
Adriaan J
AJ
Feringa
Ben L
BL
D000438:Alcohols / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D000438:Alcohols; D007659:Ketones