title: Brain abscess due to Panton-Valentine leukocidin-positive Staphylococcus aureus.
abstract: Panton-Valentine leukocidin (PVL) is a cytotoxin produced by Staphylococcus aureus that exhibits highly specific lytic activity against polymorphonuclear cells, monocytes, and macrophages. A 34-year-old man admitted for right parietal brain abscess and thickened dura mater in close proximity to a lytic bone lesion is presented. The abscess culture yielded methicillin-sensitive S. aureus that produced PVL. The patient did well after surgery and antibiotic treatment. A hematogenous infection, route of bone infection with progression to dura mater and brain parenchyma was hypothesized. To our knowledge this is the first reported case of a brain abscess due to PVL-positive S. aureus.
authors: Department of Internal Medicine (Infectious Diseases Unit), Spanish Network for Research in Infectious Disease, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, San Martin de Porres no 4, Madrid, Spain. antrammar@yahoo.es
authors: A
authors: A
authors: Ramos
authors: L
authors: L
authors: Ley
authors: E
authors: E
authors: Muñez
authors: A
authors: A
authors: Videl
authors: I
authors: I
authors: Sánchez
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000096:biosynthesis* / Q000235:genetics; D001922:Brain Abscess / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D004322:Drainage; D005098:Exotoxins / Q000096:biosynthesis* / Q000235:genetics; D006257:Head / Q000000981:diagnostic imaging; D006801:Humans; D007956:Leukocidins / Q000096:biosynthesis* / Q000235:genetics; D008279:Magnetic Resonance Imaging; D008297:Male; D011859:Radiography; D013203:Staphylococcal Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D013211:Staphylococcus aureus / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin