title: Influence of age and position on the CT number of adipose tissues in pigs.
abstract: The location of adipose tissue depots is important in determining their significance. Research into the physical and chemical differences between these depots is therefore of interest. Using image analysis, this paper examines the influence of location on the linear attenuation coefficient of adipose tissue for X-rays, in computed tomography (as indicated by CT number) at three time points. Nine pigs were CT scanned on three separate occasions approximately 1 month apart. The mean CT number was -78, -100, and -104 for visceral adipose tissue (VAT) from the first to the final scan, respectively. The corresponding CT numbers for subcutaneous adipose tissue (SAT) were -80, -101, and -106. There was a significant difference between the CT numbers at each location at each scan (P values from 0.025 to <0.001) and between the CT numbers for each location at different times (P < 0.05). In a separate analysis of the final scan session, the mean CT number of adipose tissue at increasing distances from a mathematically defined center of the animal was determined. Regression analysis showed that the CT number of adipose tissue decreases with increasing distance from the animal's center (y = -102.7 - 0.04 x, P < 0.001, where y is the predicted CT number for adipose tissue, from the animal center (x = 0) to the skin (x = 100)). It can thus be expected that the overall mean CT number for adipose tissue can be used as an indicator of the relative quantities of adipose tissue at each location if the mean for each is known.
authors: Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark. fme@life.ku.dk
authors: Fintan J
authors: FJ
authors: McEvoy
authors: Mads T
authors: MT
authors: Madsen
authors: Eiliv L
authors: EL
authors: Svalastoga
mesh_terms: D000367:Age Factors; D000375:Aging; D000818:Animals; D007090:Image Interpretation, Computer-Assisted; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging* / Q000254:growth & development; D008954:Models, Biological; D011187:Posture; D015203:Reproducibility of Results; D050151:Subcutaneous Fat / Q000000981:diagnostic imaging* / Q000254:growth & development; D013552:Swine; D036542:Tomography, Spiral Computed