Strategies for regeneration of the intervertebral disc.
Low back pain resulting from degenerative disc disease is the most common cause of disability in the UK. Current low back pain treatments are aimed at either treating the symptoms of pain, or removing the source of pain itself, but do not address the biological basis of the disease. Our increasing understanding of the molecular biological basis for degenerative disc disease has enabled the development of strategies aimed at tackling the causes of degeneration. Here we review the progress that has been made in strategies using cells, biomaterials and growth factors aimed at regenerating the human intervertebral disc.
Kalson
N S
NS
Tissue Injury and Repair Group, School of Clinical & Laboratory Sciences, University of Manchester, Manchester, M13 9PT, UK. nickkalson@gmail.com
Richardson
S
S
Hoyland
J A
JA
D000375:Aging; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D020100:Hydrogels; D007403:Intervertebral Disc / Q000166:cytology* / Q000473:pathology*; D017116:Low Back Pain / Q000628:therapy*; D010641:Phenotype; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*; D014162:Transfection
D001672:Biocompatible Materials; D016207:Cytokines; D020100:Hydrogels