[Simultaneous determination of 14 phthalate ester residues in animal innards by gas chromatography-mass spectrometry with electron impact ionization].
An analytical multiresidue method was developed for the simultaneous determination of 14 phthalate esters (PAEs) in animal innards by gas chromatography-mass spectrometry with electron impact ionization (GC-EI/MS). After the optimization of different parameters such as the extraction solvent, PAEs were extracted from animal innards with hexane-dichloromethane (1:1, v/v) in an ultrasonic bath and cleaned up on a Florisil column, then were determined by GC-EI/MS in selected ion monitoring mode with diphenyl phthalate (DPhP) as internal standard. The recovery studies were performed at 100, 200 and 400 microg/kg levels for each PAE, and the recoveries ranged from 60% - 110% with the relative standard deviations between 0.8% and 10.3% for different PAEs. The detection limit of the method was less than 1.74 microg/kg for most of PAEs except dimethoxyethyl phthalate (DMEP) and di(2-ethoxyethyl) phthalate (DEEP). The method was linear over the range of 50.0 - 800.0 microg/kg with the correlation coefficients larger than 0.999 4. The method has been successfully, applied to the determination of 14 PAEs in six animal innards.
Lin
Zhuguang
Z
Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, The Key Laboratory of Analytical Sciences of the Ministry of Education, Xiamen 361005, China. linzg@xmu.edu.cn
Sun
Ruonan
R
Zhang
Lili
L
Zou
Ximei
X
Chen
Meiyu
M
Tu
Fengzhang
F
Ma
Yu
Y
Jiang
Wenjing
W
D000818:Animals; D004583:Electrons; D004784:Environmental Monitoring / Q000379:methods*; D004785:Environmental Pollutants / Q000032:analysis / Q000737:chemistry; D004952:Esters / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D057230:Limit of Detection; D016014:Linear Models; D010795:Phthalic Acids / Q000032:analysis* / Q000737:chemistry*; D015203:Reproducibility of Results; D013997:Time Factors; D014465:Ultrasonics
D004785:Environmental Pollutants; D004952:Esters; D010795:Phthalic Acids; C032279:phthalic acid