title: Enteral nutrition in adult Crohn's disease: present status and perspectives.
abstract: Enteral nutrition has long been a therapeutic alternative often used in adult Crohn's disease patients to obtain remission or clinical response, especially in those not responding to conventional therapy such as corticosteroids. However, the increasing use of immunosuppressors (6-mercaptopurine and azathioprine, methotrexate, etc.), and the advent of biotherapies (especially anti-tumor necrosis factor-alpha (TNF-alpha) antibodies), decreased its use in adult Crohn's disease. Nevertheless, enteral nutrition remains of interest in patients presenting concomitant malnutrition (in particular in nonobstructed patients needing surgery), or in those intolerant or who failed to other therapeutics. In addition, recent studies provide data indicating its potential interest in maintenance therapy in selected patients groups. Finally, future research (in particular in the field of immuno- or pharmaconutrition) could lead to enteral formula's improvement, with better tolerance and acceptability, as well as increased efficacy.
authors: Service d'Hépato-Gastro-Entérologie et Nutrition, Pôle Reins-Digestif-Nutrition, Centre Hospitalier Universitaire de Caen, Hôpital Côte de Nacre, Caen Cedex, France.
authors: Benoît
authors: B
authors: Dupont
authors: Claire
authors: C
authors: Dupont
authors: Anne-Marie
authors: AM
authors: Justum
authors: Marie-Astrid
authors: MA
authors: Piquet
authors: Jean-Marie
authors: JM
authors: Reimund
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000150:complications / Q000628:therapy*; D004750:Enteral Nutrition / Q000379:methods*; D005973:Glutamine / Q000008:administration & dosage; D006801:Humans; D008055:Lipids / Q000008:administration & dosage; D053781:Transforming Growth Factor beta2 / Q000008:administration & dosage
chemical_list: D008055:Lipids; D053781:Transforming Growth Factor beta2; D005973:Glutamine