title: A clinicopathologic study of mantle cell lymphoma in a single center study in India.
abstract: We present clinical features, histopathology and results of treatment in cases of mantle cell lymphoma (MCL) at our hospital. We had 93 cases (2.1%) of MCL out of total 4301 cases of non-Hodgkin's lymphoma (NHL) in a 4-year period. It included 68 cases (1.7%) of MCL from 3987 cases of NHL diagnosed on histopathology. Remaining 25 cases (7.9%) diagnosed solely on peripheral blood examination were excluded. Thirty-six (85%) patients had advanced-stage disease. Sixty-three were nodal and five were extranodal (all gastrointestinal tract). Common patterns were diffuse (64%), nodular (25%) and mantle zone type (11%). Sixty-two cases had lymphocytic while six had blastic morphology (all nodal). Tumor cells expressed CD20 (100%), CD43 (94%), CD5 (89%) and cyclin D1 (85%). Bone marrow was involved in 25 (59%) cases. Thirty-two patients could be treated. Median recurrence-free survival was 22.23 months. Diffuse pattern of nodal involvement had a lower overall survival.
authors: Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India. s_gujral@hotmail.com
authors: S
authors: S
authors: Gujral
authors: A
authors: A
authors: Agarwal
authors: V
authors: V
authors: Gota
authors: R
authors: R
authors: Nair
authors: S
authors: S
authors: Gupta
authors: S K
authors: SK
authors: Pai
authors: M
authors: M
authors: Sanger
authors: T
authors: T
authors: Shet
authors: P G
authors: PG
authors: Subramanian
authors: M
authors: M
authors: Muckaden
authors: S
authors: S
authors: Laskar
mesh_terms: D000328:Adult; D000368:Aged; D018951:Antigens, CD20 / Q000096:biosynthesis; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D018956:CD5 Antigens / Q000096:biosynthesis; D019938:Cyclin D1 / Q000096:biosynthesis; D005260:Female; D041981:Gastrointestinal Tract / Q000473:pathology; D006761:Hospitals; D006801:Humans; D007194:India; D051917:Leukosialin / Q000096:biosynthesis; D020522:Lymphoma, Mantle-Cell / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis
chemical_list: D018951:Antigens, CD20; D000970:Antineoplastic Agents; C530104:CCND1 protein, human; D018956:CD5 Antigens; D051917:Leukosialin; C465014:SPN protein, human; D019938:Cyclin D1