Nomogram for deciding adjuvant treatment after surgery for oral cavity squamous cell carcinoma.
BACKGROUND
The application of appropriate adjuvant treatment after surgery for oral cavity squamous cell carcinoma (OCSCC) is predicated on accurate patient risk stratification.


METHODS
A nomogram for estimating locoregional recurrence-free survival (LRFS) after treatment of OCSCC was constructed from a cohort of 590 patients with OCSCC who were treated at Memorial Sloan-Kettering Cancer Center (MSKCC). The nomogram was validated using a series of 417 patients with OCSCC who were treated at Hospital do Cancer AC Camargo (HACC) in São Paulo, Brazil.


RESULTS
Despite significant differences between the MSKCC and HACC cohorts, the nomogram was able to predict LRFS from OCSCC with a concordance index of 0.693. Further statistical analysis showed that the nomogram was well calibrated.


CONCLUSIONS
This preliminary nomogram is the first prognostic model developed and externally validated to predict the likelihood of LRFS after treatment for an individual patient with OCSCC and may have practical utility for deciding adjuvant treatment.
Gross
Neil D
ND
Division of Head and Neck Surgery, Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, USA.
Patel
Snehal G
SG
Carvalho
Andre L
AL
Chu
Pen-Yuan
PY
Kowalski
Luis P
LP
Boyle
Jay O
JO
Shah
Jatin P
JP
Kattan
Michael W
MW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D049451:Nomograms; D009922:Oregon; D011182:Postoperative Care; D011237:Predictive Value of Tests; D018714:Radiotherapy, Adjuvant / Q000379:methods; D012306:Risk; D018570:Risk Assessment