Semi-interpenetrating polymer networks composed of silk fibroin and poly(ethylene glycol) for wound dressing.
Semi-interpenetrating polymer networks (SIPNs) composed of silk fibroin (SF) and poly(ethylene glycol) (PEG) were prepared by photopolymerization of a PEG macromer in the presence of SF to improve the mechanical properties of SF sponge as wound dressing. The morphological structure of the SF/PEG SIPNs was observed to be composed of an interconnected microporous surface and a cross-sectional area. SF/PEG SIPNs showed non-cytotoxicity evaluated by a cell proliferation method using L929 fibroblasts. Wound contraction treated with SF/PEG SIPNs sponges was faster than that of Vaseline gauze as a control. Histological observation confirmed that the deposition of collagen in the dermis was organized by covering the wound area with SF/PEG SIPNs. The above results indicated that SF/PEG SIPNs could be used as wound dressing.
Kweon
Haeyong
H
Applied Sericulture and Apiculture Division, National Institute of Agricultural Science and Technology, Suwon 441100, Korea.
Yeo
Joo-hong
JH
Lee
Kwang-gill
KG
Lee
Hyun Chul
HC
Na
Hee Sam
HS
Won
Young Ho
YH
Cho
Chong Su
CS
D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials / Q000737:chemistry* / Q000627:therapeutic use*; D002460:Cell Line; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D005349:Fibroins / Q000737:chemistry*; D008297:Male; D008422:Materials Testing; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D016062:Porosity; D051381:Rats; D017207:Rats, Sprague-Dawley; D047011:Silk / Q000737:chemistry; D014945:Wound Healing / Q000502:physiology*; D014950:Wounds, Penetrating / Q000473:pathology / Q000628:therapy*
D001672:Biocompatible Materials; D011108:Polymers; D047011:Silk; D011092:Polyethylene Glycols; D005349:Fibroins