title: Reductive stress on life span extension in C. elegans.
abstract: Recently, Schulz and colleagues have contributed to the ongoing controversy on the unproven role of oxidative stress in the aging process in their well-performed study 'Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress' (Cell Metab 2007, 6: 280-293). Here, we suggest an alternative hypothesis that reductive stress can prevent calorie-restriction induced life span extension. We draw attention to this condition as an explanation for some contradictory observations including the deleterious effects from antioxidants.
authors: Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany. ralser@molgen.mpg.de
authors: Markus
authors: M
authors: Ralser
authors: Ivor J
authors: IJ
authors: Benjamin