title: Chronic inflammation increases risk in hemodialysis patients.
abstract: Chronic inflammation is the cause of malnutrition and cardiovascular disease in hemodialysis patients. The purpose of this study was to assess C Reactive Protein (CRP) as an inflammatory marker and to define the relationship between CRP and other inflammatory and nutritional factors in this group of patients. One hundred and fourteen hemodialysis patients undergoing chronic dialysis (3 times a week for at least 4 hours) in two hemodialysis centers were enrolled in this cross-sectional study. Anthropometric and laboratory data including CRP, Il-6, hemoglobin, serum ferritin, triglyceride, cholesterol, albumin, total protein and transferrin were measured. The Kt/V for adequacy of dialysis was also calculated. There was a statistically significant correlation between the mean CRP and albumin, hemoglobin, and transferrin; while such relation was not found with BMI, ferritin, the length of dialysis, triceps skin fold thickness, mid arm circumference, mid arm muscle circumference, and Kt/V. We conclude that the negative relationship between CRP and albumin, transferrin, and hemoglobin suggests a correlation between inflammatory and nutritional factors.
authors: Department of Nephrology, Sina Hospital, Tehran, Iran. razegia@sina.tums.ac.ir
authors: Effat
authors: E
authors: Razeghi
authors: Homeira
authors: H
authors: Omati
authors: Sima
authors: S
authors: Maziar
authors: Patricia
authors: P
authors: Khashayar
authors: Mitra
authors: M
authors: Mahdavi-Mazdeh
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000209:etiology; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005293:Ferritins / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000150:complications*; D015850:Interleukin-6 / Q000097:blood; D044342:Malnutrition / Q000209:etiology; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D014168:Transferrin / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D015850:Interleukin-6; D014168:Transferrin; D014280:Triglycerides; D002097:C-Reactive Protein; D005293:Ferritins; D002784:Cholesterol