Neuromyelitis optica in a young child with positive serum autoantibody.
Relapsing neuromyelitis optica is rare in children. The identification of a highly specific serum autoantibody marker (neuromyelitis optica-immunoglobulin G) differentiates neuromyelitis optica from other demyelinating disorders, particularly in clinically challenging cases. We present a child with multiple episodes of transverse myelitis and optic neuritis with positive neuromyelitis optica-immunoglobulin G titers, consistent with a diagnosis of relapsing neuromyelitis optica. Serial titers of neuromyelitis optica-immunoglobulin G normalized during remission.
Loma
Ingrid P
IP
Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. .
Asato
Miya R
MR
Filipink
Robyn A
RA
Alper
Gulay
G
D001323:Autoantibodies / Q000097:blood*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D009188:Myelitis, Transverse / Q000175:diagnosis / Q000276:immunology; D009471:Neuromyelitis Optica / Q000175:diagnosis* / Q000276:immunology; D009902:Optic Neuritis / Q000175:diagnosis / Q000276:immunology; D012008:Recurrence
D001323:Autoantibodies; D007074:Immunoglobulin G