Argatroban anticoagulation for cardiac surgery with cardiopulmonary bypass in an infant with double outlet right ventricle and a history of heparin-induced thrombocytopenia.
Heparin-induced thrombocytopenia (HIT) is a life-threatening complication of heparin therapy. Anticoagulation in pediatric patients with HIT is challenging as there are no approved heparin substitutes. We report the use of the anticoagulant argatroban for cardiac surgery with cardiopulmonary bypass in an infant with double outlet right ventricle and a history of HIT.
Ciccolo
Michael L
ML
Cardiothoracic Surgery, Cardiovascular Surgical Associates, Las Vegas, Nevada, USA.
Bernstein
Jonathan
J
Collazos
Juan C
JC
Acherman
Ruben J
RJ
Restrepo
Humberto
H
Winters
James M
JM
Krueger
Justin
J
Evans
William N
WN
D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001120:Arginine / Q000031:analogs & derivatives; D019917:Blood Vessel Prosthesis Implantation; D002315:Cardiopulmonary Bypass; D002675:Child, Preschool; D004310:Double Outlet Right Ventricle / Q000601:surgery*; D004374:Ductus Arteriosus, Patent / Q000601:surgery; D005260:Female; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D010875:Pipecolic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D011666:Pulmonary Valve Stenosis / Q000601:surgery; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced
D000925:Anticoagulants; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban