[Preparation and in vitro study of buagafuran solid dispersions].
Solid dispersions technique was used to solidify buagafuran and improve buagafuran in vitro dissolution and stability. Buagafuran solid dispersions were prepared separately using PVPK30, PEG6000 and Poloxamer188 at various weight ratios as carriers. The status of buagafuran in solid dispersions was determined by using DSC and IR. The solubility, content and in vitro dissolution of pure drug and the solid dispersions were detected by using HPLC. When buagafuran/carrier was 1:5 or less, the drug existed in a solid dispersion form. Three kinds of carriers all can improve buagafuran dispersibility and in vitro dissolution. Accelerating experiment showed that buagafuran/PVPK30 < or = 1:10 solid dispersions was ageing-resistant, and the aspect, content and in vitro dissolution did not change after storaged over 3 months, but PEG6000, Poloxamer188 and a lower ratio PVPK30 solid dispersions became aged. Buagafuran/PVPK30 < or = 1:10 solid dispersions can be developed as buagafuran oral drug delivery carrier.
Xia
Xue-Jun
XJ
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.
Tao
Zhong-Hua
ZH
Ren
Yi
Y
Wang
Ren-Yun
RY
Liu
Yu-Ling
YL
D014151:Anti-Anxiety Agents / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004355:Drug Stability; D004356:Drug Storage; D020442:Poloxamer / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011205:Povidone / Q000737:chemistry*; D011208:Powders; D012717:Sesquiterpenes / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility
D014151:Anti-Anxiety Agents; D004337:Drug Carriers; D011208:Powders; D012717:Sesquiterpenes; C530322:buagafuran; D020442:Poloxamer; D011092:Polyethylene Glycols; D011205:Povidone