Topical fusidic acid for treatment of Clostridium perfringens Keratitis.
OBJECTIVE
To report the therapeutic outcome of primary corneal infection by Clostridium perfringens.


METHODS
A 65-year-old cleaning lady had pain, decreased visual acuity, redness, and photophobia in her left eye for 4 days. A paracentral corneal ulcer with subepithelial bullae and several frothy bubbles in the ulcer bed was found. Two different cultures were positive for C. perfringens.


RESULTS
Treatment with topical fusidic acid 1% was given, and the corneal infiltrate regressed within 6 weeks to a faint corneal opacity.


CONCLUSIONS
Clostridium perfringens keratitis can be treated successfully with topical fusidic acid.
Mayo
Isabel
I
Department of Ophthalmology, Hospital La Fe, Valencia, Spain.
Puchades
Francesc
F
de la Paz
Maria Fideliz
MF
D000287:Administration, Topical; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003015:Clostridium Infections / Q000188:drug therapy* / Q000382:microbiology; D003016:Clostridium perfringens / Q000302:isolation & purification*; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000382:microbiology; D015818:Eye Infections, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005672:Fusidic Acid / Q000008:administration & dosage*; D006801:Humans; D016896:Treatment Outcome; D014792:Visual Acuity
D000900:Anti-Bacterial Agents; D005672:Fusidic Acid