title: Immunohistochemical identification and localization of orexin A and orexin type 2 receptor in the horse gastrointestinal tract.
abstract: The aim of the present study was to investigate the presence and the distribution of cells containing orexin A and orexin type 2 receptor in the horse stomach and gut, by means of immunohistochemical techniques. Orexin A was identified in the stomach fundic and pyloric regions and in the duodenum. In the same stomach regions, a large subset of orexin A-positive cells also showed orexin type 2 receptor-like immunoreactivity. Moreover, in the duodenum, many of them, seemed to store serotonin. Characteristically, enteric neurons or ganglia also displayed orexin A and, sometimes, orexin type 2 receptor immunoreaction. Orexin A and orexin type 2 receptor immunoreactivity was also found in the nerve fibers in the enteric submucosal layer. Our results, together with data present in the literature, could contribute to the understanding of complex mechanisms regulating the horse gut functionality that are depending very likely on the consequence of the co-operation of both a central and a peripheral control.
authors: Dipartimento di Scienze Biopatologiche Veterinarie ed Igiene delle Produzioni Animali ed Alimentari, Sezione di Anatomia Veterinaria, Via San Costanzo 4, 06126 Perugia, Italy. cecilia.dallaglio@unipg.it
authors: Cecilia
authors: C
authors: Dall'aglio
authors: Luisa
authors: L
authors: Pascucci
authors: Francesca
authors: F
authors: Mercati
authors: Andrea
authors: A
authors: Giontella
authors: Vera
authors: V
authors: Pedini
authors: Piero
authors: P
authors: Ceccarelli
mesh_terms: D000818:Animals; D005260:Female; D041981:Gastrointestinal Tract / Q000166:cytology / Q000378:metabolism*; D006736:Horses / Q000378:metabolism*; D007150:Immunohistochemistry / Q000662:veterinary; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008297:Male; D009479:Neuropeptides / Q000378:metabolism*; D064446:Orexin Receptors; D000068797:Orexins; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D018013:Receptors, Neuropeptide / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D064446:Orexin Receptors; D000068797:Orexins; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide