title: Retinal pigment epithelial atrophy following indocyanine green dye-assisted surgery for serous macular detachment.
abstract: To report subretinal migration of indocyanine green dye (ICG) and subsequent retinal pigment epithelial (RPE) atrophy during macular surgery for serous macular detachment. A 65-year-old woman presented with residual epiretinal membrane and serous detachment of the macula following vitreoretinal surgery for epiretinal membrane. She underwent resurgery with ICG-assisted internal limiting membrane peeling and intraocular tamponade. Intraoperatively a large area of subretinal ICG was seen with subsequent RPE mottling and atrophy of the macula in the area involved during follow-up. This case demonstrates that subretinal migration of ICG is possible and can be toxic to RPE.
authors: Smt. Kanuri Santhamma Retina Vitreous Centre, L.V. Prasad Eye Institute, Hyderabad, India. nazimul@lvpei.org
authors: Nazimul
authors: N
authors: Hussain
authors: Subhadra
authors: S
authors: Jalali
authors: Alka
authors: A
authors: Rani
authors: Hema
authors: H
authors: Rawal
mesh_terms: D000368:Aged; D001284:Atrophy / Q000139:chemically induced / Q000473:pathology; D004396:Coloring Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage / Q000009:adverse effects*; D007267:Injections; D008266:Macula Lutea / Q000473:pathology*; D010857:Pigment Epithelium of Eye / Q000187:drug effects / Q000473:pathology*; D011183:Postoperative Complications; D012163:Retinal Detachment / Q000473:pathology / Q000601:surgery*; D041623:Tomography, Optical Coherence; D014822:Vitreous Body
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green