[Association of pulmonar tuberculosis with HLA system antigens in Northeastern Mexico].
BACKGROUND
Genetic susceptibility to pulmonary tuberculosis (PTb) has been associated with the HLA (Antigens of the Human Leukocytes) system of the MHC (Major Histocompatibility Complex), mainly with HLA-DR and-DQ antigens. Based on this assumption we carried out a case control study to determine the association of PTb with the HLA-DR and-DQ antigens among a sample of patients attending a medical unit belonging to the Mexican Social Security System (IMSS).


METHODS
HLA system phenotypes from cases (n=50) and controls (n=417), were defined serologically using a complement dependent microlymphocytotoxic assay. B lymphocytes were obtained using immunobeads. The allele and haplotype frequencies were determined using the Arlequin version 3.01 computer software. Relative risk (RR) was calculated with the Epimax Table Calculator.


RESULTS
The alelles HLA-DR11(5), -DR16(2) and -DQ7(3) and haplotypes /DR11(5)-DQ7(3), /DR14(6)-DQS(1) and /DR16(2)-DQ7(3) had a higher frequency in cases than in controls (RR>1, p<0.05). The HLA-DR17(3) and DQ8(3) alelles and /DR17(3)-DQ2 and /DR4-DQ8(3) haplotypes had a higher frequency among controls than among cases (RR<1, p<.05).


CONCLUSIONS
These results indicate an association between PTb with the HLA-DR and -DQ antigens in a Mexican sample. Our results are similar to those found in the international literature.
Rojas-Alvarado
María de los Angeles
Mde L
Departamento de Genética de Poblaciones y Bioinformática, Centro de Investigación Biomédica del Noreste, Monterrey, N.L., México.
Díaz-Mendoza
María Luisa
ML
Said-Fernández
Salvador
S
Caballero-Olín
Guillermo
G
Cerda-Flores
Ricardo M
RM
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006683:HLA-DQ Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens