Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients.
Serum PEDF levels (mean (S.D.)) were increased in 96 Type 2 diabetic vs. 54 non-diabetic subjects; 5.3 (2.8) vs. 3.2 (2.0)mug/ml, p<0.001. In diabetes, PEDF correlated with BMI, serum creatinine and LDL-cholesterol, but not with other lipids, HbA1c or CRP. PEDF did not differ by drugs, complications, or gender.
Jenkins
Alicia
A
Department of Medicine, Endocrinology, Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Zhang
Sarah X
SX
Gosmanova
Albina
A
Aston
Christopher
C
Dashti
Azar
A
Baker
Mary Zoe
MZ
Lyons
Timothy
T
Ma
Jian-Xing
JX
D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood; D003404:Creatinine / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005136:Eye Proteins / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D015843:Serpins / Q000097:blood*; D000099174:Pigment Epithelium-Derived Factor
D002097:C-Reactive Protein; D008078:Cholesterol, LDL; D003404:Creatinine; D005136:Eye Proteins; D006442:Glycated Hemoglobin; D008055:Lipids; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor