Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer.
The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics.
Akkiprik
Mustafa
M
Department of Medical Biology, Marmara University, School of Medicine, 34668 Istanbul, Turkey. akkiprik@yahoo.com
Feng
Yumei
Y
Wang
Huamin
H
Chen
Kexin
K
Hu
Limei
L
Sahin
Aysegul
A
Krishnamurthy
Savitri
S
Ozer
Ayse
A
Hao
Xishan
X
Zhang
Wei
W
D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D049109:Cell Proliferation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018975:Insulin-Like Growth Factor Binding Protein 5 / Q000378:metabolism*; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism; D008495:Medical Oncology / Q000379:methods; D051379:Mice; D011379:Prognosis; D017434:Protein Structure, Tertiary; D014158:Transcription, Genetic
D018975:Insulin-Like Growth Factor Binding Protein 5; D018969:Insulin-Like Growth Factor Binding Proteins