Dinucleotide-sensing proteins: linking signaling networks and regulating transcription.
Differential binding of dinucleotides to key regulatory proteins can modulate their interactions with other proteins and, in some cases, can signal fluctuations in the cellular redox state, to produce changes in transcription and physiological state. The dinucleotide-binding proteins human HSCARG and yeast transcription repressor Gal80p are examples that offer exciting glimpses into the potential for dinucleotide-sensing proteins to couple fluctuations in dinucleotide ratios to changes in transcription and to act as networking agents linking different classes of signaling molecules.
Lamb
Heather K
HK
Institute for Cell and Molecular Biosciences, Catherine Cookson Building, Newcastle University, Framlington Place, Newcastle upon Tyne NE24HH, UK.
Stammers
David K
DK
Hawkins
Alastair R
AR
D005656:Fungal Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D006367:HeLa Cells; D006801:Humans; D008954:Models, Biological; D008968:Molecular Conformation; D009249:NADP / Q000737:chemistry; D009711:Nucleotides / Q000737:chemistry*; D010084:Oxidation-Reduction; D011485:Protein Binding; D012097:Repressor Proteins / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry; D015398:Signal Transduction; D014157:Transcription Factors / Q000737:chemistry
D005656:Fungal Proteins; C055002:GAL80 protein, S cerevisiae; C520476:NMRAL1 protein, human; D009711:Nucleotides; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D009249:NADP