title: [Association of pulmonar tuberculosis with HLA system antigens in Northeastern Mexico].
abstract: BACKGROUND
  Genetic susceptibility to pulmonary tuberculosis (PTb) has been associated with the HLA (Antigens of the Human Leukocytes) system of the MHC (Major Histocompatibility Complex), mainly with HLA-DR and-DQ antigens. Based on this assumption we carried out a case control study to determine the association of PTb with the HLA-DR and-DQ antigens among a sample of patients attending a medical unit belonging to the Mexican Social Security System (IMSS).
  
  
  METHODS
  HLA system phenotypes from cases (n=50) and controls (n=417), were defined serologically using a complement dependent microlymphocytotoxic assay. B lymphocytes were obtained using immunobeads. The allele and haplotype frequencies were determined using the Arlequin version 3.01 computer software. Relative risk (RR) was calculated with the Epimax Table Calculator.
  
  
  RESULTS
  The alelles HLA-DR11(5), -DR16(2) and -DQ7(3) and haplotypes /DR11(5)-DQ7(3), /DR14(6)-DQS(1) and /DR16(2)-DQ7(3) had a higher frequency in cases than in controls (RR>1, p<0.05). The HLA-DR17(3) and DQ8(3) alelles and /DR17(3)-DQ2 and /DR4-DQ8(3) haplotypes had a higher frequency among controls than among cases (RR<1, p<.05).
  
  
  CONCLUSIONS
  These results indicate an association between PTb with the HLA-DR and -DQ antigens in a Mexican sample. Our results are similar to those found in the international literature.
authors: Departamento de Genética de Poblaciones y Bioinformática, Centro de Investigación Biomédica del Noreste, Monterrey, N.L., México.
authors: María de los Angeles
authors: Mde L
authors: Rojas-Alvarado
authors: María Luisa
authors: ML
authors: Díaz-Mendoza
authors: Salvador
authors: S
authors: Said-Fernández
authors: Guillermo
authors: G
authors: Caballero-Olín
authors: Ricardo M
authors: RM
authors: Cerda-Flores
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006683:HLA-DQ Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens