[Application of NOD/SCID mice in research of experimental hematology - review].
NOD/SCID (non-obese diabetic/severe combined immunodeficient) mice are immune deficient mice which are made by backcross of severe combined immunodeficient mice with non-obese diabetic mice strains. NOD/SCID mice are both innate immune deficiencies and lack of T and B lymphocytes. Various tumor cells can be implanted in this kind of mice, the rejection and graft-versus-host disease (GVHD) occur fewer. Therefore, NOD/SCID mice gradually become a useful tool for the study on Experimental Hematology. This paper comprehensively reviews the biological characteristics of NOD/SCID mice, the establishment of human leukemia model, stem cell transplantation, drug research, deficiency and improvement of NOD/SCID mice in application for study.
Yu
Wen-Jun
WJ
Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Yang
Wen-Hua
WH
Shi
Zhe-Xin
ZX
Yang
Xiang-Dong
XD
Wang
Hui-Juan
HJ
D000818:Animals; D004195:Disease Models, Animal; D006405:Hematology / Q000379:methods*; D007938:Leukemia; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D023421:Models, Animal; D012106:Research / Q000639:trends