MIF in autoimmunity and novel therapeutic approaches.
Macrophage migration inhibitory factor (MIF) is a multipotent cytokine implicated in the pathogenesis of numerous inflammatory and autoimmune disorders. Since anti-cytokine therapy is considered to be a promising therapeutic strategy, selective targeting of MIF with either anti-MIF antibody or specific chemical MIF inhibitors might offer new therapeutic avenues for these disorders. Considering the unique relationship between MIF and glucocorticoids, therapeutic antagonism of MIF could also represent an effective approach for steroid-sparing therapies in patients with refractory autoimmune diseases.
Stosic-Grujicic
Stanislava
S
Institute for Biological Research Sinisa Stankovic, Belgrade, Serbia.
Stojanovic
Ivana
I
Nicoletti
Ferdinando
F
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology* / Q000517:prevention & control; D002908:Chronic Disease; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D005938:Glucocorticoids / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D007116:Immunization, Passive / Q000639:trends; D019746:Intramolecular Oxidoreductases / Q000276:immunology* / Q000378:metabolism*; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology* / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D009928:Organ Specificity / Q000276:immunology; D012008:Recurrence; D015398:Signal Transduction / Q000276:immunology
D000911:Antibodies, Monoclonal; D016207:Cytokines; D005938:Glucocorticoids; D008263:Macrophage Migration-Inhibitory Factors; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human