Novel nitrofurazone derivatives endowed with antimicrobial activity.
The N-alkylated derivatives from nitrofurazone were synthesised and evaluated in vitro for their efficacy as antimicrobial agents against representative strains, including methicillin-resistant Staphylococcus aureus (MRSA). The derivative 2a demonstrated greater activity than the prototype and was comparable to currently used antimicrobial drugs.
Brondani
Dalci J
DJ
LabSINFA - Laboratory for the Planning, Synthesis, and Evaluation of Pharmaceutical Products, Department of Pharmaceutical Science, Centre for Health Science, Federal University of Pernambuco, Recife, PE, Brazil.
Caetano
Nelly
N
Moreira
Diogo R de M
DR
Soares
Rogério R
RR
Lima
Vânia T
VT
de Araújo
Janete M
JM
de Abreu
Fabiane C
FC
de Oliveira
Boaz G
BG
Hernandes
Marcelo Z
MZ
Leite
Ana C L
AC
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009583:Nitrofurazone / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009583:Nitrofurazone