Expressions of steroid receptors and Ki67 in first-trimester decidua and chorionic villi exposed to levonorgestrel used for emergency contraception.
Levonorgestrel (1.5 mg) is commonly used for emergency contraception to prevent an unwanted pregnancy after an unprotected intercourse. We found that postovulatory administration of 1.5 mg of levonorgestrel to women with a subsequent or existing early pregnancy did not affect the immunohistochemical expressions of estrogen receptors (ER(alpha), ER(beta)), P receptors (PR(B), PR(A+B)), androgen receptor (AR), or proliferation index Ki67 in the first-trimester decidua and chorionic villi.
Meng
Chun-Xia
CX
Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Cheng
Li-Nan
LN
Lalitkumar
Parameswaran Grace Luther
PG
Zhang
Lin
L
Zhang
Hui-Juan
HJ
Gemzell-Danielsson
Kristina
K
D000328:Adult; D049109:Cell Proliferation; D002824:Chorionic Villi / Q000378:metabolism*; D044363:Contraception, Postcoital / Q000379:methods*; D003271:Contraceptive Agents, Female / Q000494:pharmacology; D003656:Decidua / Q000166:cytology / Q000378:metabolism*; D047628:Estrogen Receptor alpha / Q000187:drug effects / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000187:drug effects / Q000378:metabolism*; D016912:Levonorgestrel / Q000494:pharmacology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000378:metabolism; D011944:Receptors, Androgen / Q000187:drug effects / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000187:drug effects / Q000378:metabolism*
D003271:Contraceptive Agents, Female; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D019394:Ki-67 Antigen; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C101118:progesterone receptor A; C097314:progesterone receptor B; D016912:Levonorgestrel