title: Cytomegalovirus infection with lissencephaly.
abstract: Lissencephaly is a malformation of the brain in which the brain surface is smooth, rather than convoluted. Among the various causes of lissencephaly, infection by a virus during pregnancy plays an important role. Cytomegalovirus (CMV) is an important pathogen causing this anomaly. We present this case of a young female with 24-week-gestation diagnosed on ultrasound as carrying an anomalous fetus with lissencephalic features. At autopsy, there were multiple intra-nuclear CMV inclusions in the brain and the kidneys. This case is presented for its rarity and for the documentation of the tissue localization of CMV inclusions at autopsy.
authors: Department of Pathology, Sri Ramachandra University, Chennai, Tamil Nadu, India.
authors: Leena Dennis
authors: LD
authors: Joseph
authors: Pushpalatha
authors: Sarah
authors: S
authors: Kuruvilla
mesh_terms: D037881:Aborted Fetus / Q000473:pathology* / Q000821:virology*; D001921:Brain / Q000473:pathology / Q000821:virology; D002467:Cell Nucleus / Q000821:virology; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D045586:Intranuclear Inclusion Bodies; D007668:Kidney / Q000473:pathology / Q000821:virology; D054082:Lissencephaly / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology* / Q000821:virology; D011247:Pregnancy; D014463:Ultrasonography; D055815:Young Adult