A de novo desmoid tumor of the surgical site following foramen magnum meningioma resection in a patient with Gardner's Syndrome: a case report and review of the literature.
BACKGROUND
Gardner's Syndrome is a familial adenomatous polyposis (FAP) syndrome that presents with colorectal polyps, craniofacial osteomas, lipomas, epidermoid cysts, and ampullary cancers. These patients are at significant risk for developing desmoid tumors, which are locally infiltrating fibromatous lesions. These are most commonly found in the abdominal cavity, but may be extra-abdominal. Although FAP-associated desmoid tumors often occur at sites of surgical scarring, this is the first report following resection of an intracranial meningioma.


METHODS
We present a patient with Gardner's Syndrome who underwent resection of a foramen magnum meningioma and subsequently developed a de novo desmoid tumor at the surgical site. She had a complete surgical resection of the tumor but did not receive adjuvant therapy. At the time of her death 7 years after her desmoid tumor resection, she had no evidence of a recurrence at the skull base.


CONCLUSIONS
This case report emphasizes the need for careful follow-up in patients with Gardner's Syndrome who undergo resection of a meningioma or other neurosurgical procedure. Adjuvant therapy may be of value in these patients.
Kenning
Tyler James
TJ
Division of Neurosurgery, Department of Surgery, Albany Medical Center, 47 New Scotland Avenue, MC-10, Albany, NY, 12208, USA. kennint@mail.amc.edu
Kanwar
Vikramjit S
VS
Qian
Jiang
J
Deshaies
Eric M
EM
D000368:Aged; D005260:Female; D018222:Desmoid Tumors / Q000175:diagnosis / Q000209:etiology*; D005539:Foramen Magnum / Q000473:pathology / Q000601:surgery*; D005736:Gardner Syndrome / Q000150:complications; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008579:Meningioma / Q000150:complications / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications; D019292:Skull Base Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*