title: Carcinoma-associated retinopathy-an electrophysiological and immunohistochemical correlation.
abstract: OBJECTIVE
  To correlate the clinical, electrophysiological, and immunohistochemical findings in patients suffering from carcinoma-associated retinopathy.
  
  
  METHODS
  Four patients with visual loss were included in this retrospective, observational consecutive case series. Electrophysiology and immunohistochemical analysis were performed to confirm the diagnosis of carcinoma-associated retinopathy.
  
  
  RESULTS
  Immunohistochemistry revealed a marked interindividual variability of antibody reactions against different retinal cell layers of individual patients. The electrophysiological changes corresponded to the respective immunohistochemical findings.
  
  
  CONCLUSIONS
  Carcinoma-associated retinopathy is a heterogeneous disease, caused by different antiretinal antibodies and leading to different electrophysiological abnormalities. Diagnosis should not be delayed as undetected and thus untreated malignancy can be the cause.
authors: Department of Ophthalmology, University of Erlangen-Nuernberg, Erlangen, Germany. barbara.link@uk-erlangen.de
authors: Barbara
authors: B
authors: Link
authors: Ursula
authors: U
authors: Schlötzer-Schrehardt
authors: Anselm
authors: A
authors: Jünemann
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D004585:Electrooculography; D004594:Electrophysiology; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000276:immunology; D012160:Retina / Q000276:immunology; D012164:Retinal Diseases / Q000175:diagnosis* / Q000276:immunology; D012189:Retrospective Studies
chemical_list: D001323:Autoantibodies