Memory impairment correlates with increased S100B serum concentrations in patients with chronic schizophrenia.
Astrocyte activation indicated by increased S100B is considered a potential pathogenic factor for schizophrenia. To investigate the relationship between astrocyte activation and cognitive performance, S100B serum concentration, memory performance, and psychopathology were assessed in 40 first-episode and 35 chronic schizophrenia patients upon admission and after four weeks of treatment. Chronic schizophrenia patients with high S100B were impaired concerning verbal memory performance (AVLT, Auditory Verbal Learning Test) compared to chronic and first-episode patients with low S100B levels. The findings support the hypothesis that astrocyte activation might contribute to the development of cognitive dysfunction in schizophrenia.
Pedersen
Anya
A
University Medical Faculty, Department of Psychiatry, 48149 Münster, Germany. Anya.Pedersen@ukmuenster.de
Diedrich
Markus
M
Kaestner
Florian
F
Koelkebeck
Katja
K
Ohrmann
Patricia
P
Ponath
Gerald
G
Kipp
Frank
F
Abel
Simone
S
Siegmund
Ansgar
A
Suslow
Thomas
T
von Eiff
Christof
C
Arolt
Volker
V
Rothermundt
Matthias
M
D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000097:blood* / Q000209:etiology*; D009414:Nerve Growth Factors / Q000097:blood*; D009483:Neuropsychological Tests; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D012559:Schizophrenia / Q000097:blood / Q000150:complications*; D014706:Verbal Learning / Q000502:physiology; D055815:Young Adult
D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human