title: Transmission dynamics of Borrelia burgdorferi s.s. during the key third day of feeding by nymphal Ixodes scapularis (Acari: Ixodidae).
abstract: Nymphal Ixodes scapularis Say are the principal vectors of Lyme disease spirochetes (Borrelia burgdorferi sensu stricto) in the eastern United States. Physicians frequently face the decision of whether or not to administer prophylactic antibiotics to human tick bite victims in Lyme disease endemic regions, based on the overall probability that such bites will result in infection with B. burgdorferi s.s. We evaluated the transmission dynamics of B. burgdorferi s.s. during the key third day of nymphal I. scapularis feeding, when the risk of transmission rapidly increases. The cumulative probability that 50% of infected ticks transmitted B. burgdorferi s.s. occurred at 68 h of tick attachment and our overall estimate that a human tick bite would result in transmission of B. burgdorferi s.s. was 2.4%.
authors: Division of Vector-Borne Infectious Diseases, NCZVED, CCID, Centers for Disease Control and Prevention, 3150 Rampart Rd., Ft. Collins, CO 80521 USA.
authors: Andrias
authors: A
authors: Hojgaard
authors: Rebecca J
authors: RJ
authors: Eisen
authors: Joseph
authors: J
authors: Piesman
mesh_terms: D000821:Animal Feed; D000818:Animals; D001733:Bites and Stings / Q000382:microbiology; D025065:Borrelia burgdorferi / Q000235:genetics / Q000472:pathogenicity*; D017931:DNA Primers; D004269:DNA, Bacterial / Q000235:genetics; D006801:Humans; D018884:Ixodes / Q000382:microbiology*; D008193:Lyme Disease / Q000635:transmission*; D011336:Probability; D013997:Time Factors
chemical_list: D017931:DNA Primers; D004269:DNA, Bacterial