Trichinella spiralis: nurse cell formation with emphasis on analogy to muscle cell repair.
Trichinella infection results in formation of a capsule in infected muscles. The capsule is a residence of the parasite which is composed of the nurse cell and fibrous wall. The process of nurse cell formation is complex and includes infected muscle cell response (de-differentiation, cell cycle re-entry and arrest) and satellite cell responses (activation, proliferation and differentiation). Some events that occur during the nurse cell formation are analogous to those occurring during muscle cell regeneration/repair. This article reviews capsule formation with emphasis on this analogy.
Wu
Zhiliang
Z
Department of Parasitology, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu, 501-1194, Japan. yu3@gifu-u.ac.jp.
Sofronic-Milosavljevic
Lj
Lj
Nagano
Isao
I
Takahashi
Yuzo
Y