Therapeutic angiogenesis: a new treatment approach for ischemic heart disease--Part II.
Angiogenesis is the biologic process of forming new blood vessels and is being investigated as an innovative therapeutic approach to help manage ischemic heart disease and peripheral vascular disease. Research studies have identified various angiogenic growth factors and progenitor cells that can enhance new blood vessel formation. This is Part II of an article that began publication in the July/August issue of Cardiology in Review. Preclinical investigations in animal models have explored the potential use of growth factors with and without progenitor cells to treat myocardial ischemia. The results of clinical trials with growth factor infusions and gene therapy techniques to enhance growth factor production have shown some promise, but therapeutic angiogenesis remains at an early stage of development.
Ahn
Anna
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Department of Medicine, Long Island Jewish Medical Center/Albert Einstein College of Medicine, New Hyde Park, New York, USA.
Frishman
William H
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Gutwein
Andrew
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Passeri
Jonathan
J
Nelson
Michael
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D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000818:Animals; D005346:Fibroblast Growth Factors / Q000187:drug effects; D015316:Genetic Therapy; D006801:Humans; D017202:Myocardial Ischemia / Q000628:therapy*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D042461:Vascular Endothelial Growth Factor A / Q000187:drug effects
D043925:Angiogenesis Inducing Agents; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors