title: [Preliminary evaluation of maggot (Diptera: Calliphoridae) therapy as a potential treatment for leishmaniasis ulcers].
abstract: BACKGROUND
  Maggot debridement therapy has been widely used for treating a variety of scarred-over soft-tissue wounds. Published accounts record several illnesses in which treatment with larval therapy has promoted injury healing in conjunction with infection by bacterial pathogens resistant to conventional antibiotics.
  
  
  OBJECTIVE
  An initial test of the maggot therapy was developed for cutaneous injuries produced by Leishmania amazonensis.
  
  
  METHODS
  An experimental design based on an animal model with three replicates in Mesocricetus aureatus (Rodentia: Muridae) was used to evaluate size variation lesion before and after after larval therapy with Lucilia sericata maggots . The criteria used for therapy evaluation were lesion size, maggot application time, and presence or absence of edema and secretions.
  
  
  RESULTS
  Effective scarring and wound healing was observed after therapy with L. sericata larvae, i.e. 80% to 100% lesion area reduction after 12 hours.
  
  
  CONCLUSIONS
  The preliminary results suggest that fly maggots of L. sericata have a potential use as natural medical and veterinary alternative therapy for the cutaneous leishmaniasis.
authors: Grupo de Ecología de Vectores, Departamento de Estudios Ambientales, Facultad de Ciencias Biológicas, Universidad Simón Bolívar, Caracas, Venezuela. jarrivillaga@usb.ve
authors: Jazzmin
authors: J
authors: Arrivillaga
authors: Jaime
authors: J
authors: Rodríguez
authors: Milagros
authors: M
authors: Oviedo
mesh_terms: D000818:Animals; D003411:Arvicolinae; D006224:Cricetinae; D003646:Debridement / Q000379:methods*; D004175:Diptera; D006097:Granulation Tissue / Q000473:pathology; D006801:Humans; D007814:Larva; D016773:Leishmaniasis, Cutaneous / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D008297:Male; D014456:Ulcer / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D014945:Wound Healing