title: Plasma adiponectin is associated with plasma brain natriuretic peptide and cardiac function in healthy subjects.
abstract: The aim of this study was to evaluate the relationship between the plasma adiponectin level, plasma brain natriuretic peptide (BNP) level, and cardiac function in healthy subjects. We obtained clinical data and performed blood tests, including measurement of the plasma adiponectin and BNP levels, in 1,538 healthy persons from Arita-cho, a rural area of Japan. Six hundred and eight subjects also underwent echocardiography. There was a significant positive correlation between their plasma BNP and adiponectin levels in simple regression analysis (standardized regression coefficient [beta] = 0.34). Multivariate regression analysis revealed that the plasma adiponectin level was independently associated with the plasma BNP level (beta = 0.12), as well as with the age (beta = 0.22), male gender (beta = -0.26), waist circumference (beta = -0.16), and the plasma levels of high-density lipoprotein cholesterol (beta = 0.13), triglycerides (beta = -0.16), aspartate aminotransferase (beta = 0.08), gamma-glutamyl transpeptidase (beta = -0.10), uric acid (beta = -0.07), and creatinine (beta = 0.08). We also found a link between plasma adiponectin and the left atrial diameter index (beta = 0.08) or left ventricular diameter index (beta = 0.11), even after adjustment for age, sex, and body mass index. The plasma adiponectin level increased along with an increase of plasma BNP in healthy subjects independently of other confounding factors, demonstrating that adiponectin reflects cardiac function.
authors: Cardiovascular Division of Medicine, National Cardiovascular Center, Suita, Japan.
authors: Takahiro
authors: T
authors: Ohara
authors: Jiyoong
authors: J
authors: Kim
authors: Masanori
authors: M
authors: Asakura
authors: Hiroshi
authors: H
authors: Asanuma
authors: Satoshi
authors: S
authors: Nakatani
authors: Kazuhiko
authors: K
authors: Hashimura
authors: Hideaki
authors: H
authors: Kanzaki
authors: Tohru
authors: T
authors: Funahashi
authors: Hitonobu
authors: H
authors: Tomoike
authors: Masafumi
authors: M
authors: Kitakaze
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D001783:Blood Flow Velocity; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006321:Heart / Q000502:physiology*; D006352:Heart Ventricles / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012044:Regression Analysis
chemical_list: D052242:Adiponectin; D020097:Natriuretic Peptide, Brain