Adiponectin: good, bad, or just plain ugly?
It has been suggested that adiponectin has antiatherogenic, anti-inflammatory, and insulin-sensitizing properties. However, studies in humans have reported inverse as well as positive associations between adiponectin concentrations and disease states. This Commentary discusses the apparent conflict in the literature.
Costacou
Tina
T
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. costacout@edc.pitt.edu
Orchard
Trevor J
TJ
D052242:Adiponectin / Q000502:physiology; D000419:Albuminuria / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D007674:Kidney Diseases / Q000503:physiopathology
C499918:ADIPOQ protein, human; D052242:Adiponectin