title: In-stent restenosis in bare metal stents versus sirolimus-eluting stents after primary coronary intervention for acute myocardial infarction and subsequent transcoronary transplantation of autologous stem cells.
abstract: BACKGROUND
  Following stenting for acute myocardial infarction, transcoronary transplantation of granulocyte-colony stimulating factor (G-CSF) mobilized autologous stem cells (ASC) has been shown to result in an increased in-stent restenosis rate of bare metal stents (BMS).
  
  
  OBJECTIVE
  This study sought to compare the extent of neointimal growth in BMS and sirolimus-eluting stents (SES) after primary implantation, and subsequent transcoronary transplantation of G-CSF mobilized stem cells.
  
  
  METHODS
  Patients with stenting of the left anterior descending coronary artery for acute anterior myocardial infarction were randomly assigned to receive a BMS or SES. Intracoronary stem cell injection was performed after G-CSF application for at least 4 d and cell apheresis. The angiograms obtained after cell transplantation and after 6 mo were analyzed by quantitative coronary angiography.
  
  
  RESULTS
  We performed primary stenting and stem cell transplantion in 16 patients who received a BMS (n = 8) or an SES (n = 8). In 2 patients with a BMS, late stent thrombosis occurred after 58 d and 177 d, respectively. In the remaining patients, control angiography after 6 mo revealed in-stent restenosis of >50% in no patients with SES but in 4 patients with BMS (67%). Late lumen loss and in-stent plaque volume were significantly higher in patients with BMS compared with patients with SES.
  
  
  CONCLUSIONS
  Compared with BMS, SES impair in-stent intima hyperplasia after stenting for acute myocardial infarction and transcoronary transplantation of G-CSF mobilized ASC.
authors: Cardiovascular Division, General and Academic Teaching Hospital of Linz, Linz, Austria. clemens.steinwender@akh.linz.at
authors: Clemens
authors: C
authors: Steinwender
authors: Robert
authors: R
authors: Hofmann
authors: Alexander
authors: A
authors: Kypta
authors: Juergen
authors: J
authors: Kammler
authors: Klaus
authors: K
authors: Kerschner
authors: Michael
authors: M
authors: Grund
authors: Kurt
authors: K
authors: Sihorsch
authors: Christian
authors: C
authors: Gabriel
authors: Franz
authors: F
authors: Leisch
mesh_terms: D023903:Coronary Restenosis / Q000209:etiology*; D054855:Drug-Eluting Stents; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D020123:Sirolimus / Q000008:administration & dosage*; D033581:Stem Cell Transplantation; D015607:Stents
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D020123:Sirolimus