title: The fault is not in her parents but in her insula--a neurobiological hypothesis of anorexia nervosa.
abstract: The reported abnormalities of brain function in anorexia nervosa (AN) include impairment of neural circuits involving cortical (orbito-frontal, somatosensory and parietal) and sub-cortical (amygdala, hippocampus, thalamus, hypothalamus and striatum) structures. The insular cortex serves an integrative function for all the structures relevant to the features of AN and as such may be central to this impairment. We hypothesise that a rate limiting dysfunction of neural circuitry integrated by the insula can account for the clinical phenomena of AN. Such dysfunction could account for the known psychopathology, neuroimaging abnormalities and neuropsychological deficits. Proposals to test this hypothesis are made.
authors: University of New South Wales, Australia.
authors: Ken
authors: K
authors: Nunn
authors: Ian
authors: I
authors: Frampton
authors: Isky
authors: I
authors: Gordon
authors: Bryan
authors: B
authors: Lask
mesh_terms: D000856:Anorexia Nervosa / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology; D001066:Appetite; D001921:Brain / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology*; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D006801:Humans; D009415:Nerve Net / Q000503:physiopathology; D010287:Parent-Child Relations; D015203:Reproducibility of Results