Dry coating of soft gelatin capsules with HPMCAS.
Dry coating is an innovative powder-layering technique that enables the formation of coatings on solid dosage forms with no need for using water or organic solvents. This technique envisages the distribution of polymer powder blends onto substrate cores and the concurrent or alternate nebulization of liquid plasticizers. In this work, a dry coating process based on hydroxypropyl methylcellulose acetate succinate (HPMCAS) was set up in a rotary fluid bed equipment to prepare enteric-coated soft gelatin capsules. Promising results were obtained in terms of process feasibility and product characteristics, thus suggesting the possibility of advantageous applications for the investigated technique when dealing with gelatin capsule substrates.
Cerea
Matteo
M
Istituto di Chimica Farmaceutica e Tossicologica "P. Pratesi", Universita degli Studi di Milano, Milan, Italy. matteo.cerea@unimi.it
Foppoli
Anastasia
A
Maroni
Alessandra
A
Palugan
Luca
L
Zema
Lucia
L
Sangalli
Maria Edvige
ME
D002214:Capsules; D005079:Excipients / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D005780:Gelatin / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D011208:Powders; D013678:Technology, Pharmaceutical / Q000379:methods*
D002214:Capsules; D005079:Excipients; D011208:Powders; C048331:hydroxypropylmethylcellulose acetate succinate; D005780:Gelatin; D008747:Methylcellulose