title: Microsatellite instability in sporadic colon carcinomas has no independent prognostic value in a Belgian study population.
abstract: Pathological stage is currently the most important determinant of colorectal cancer prognosis. Hence, identification of additional prognostic markers is warranted. This study aimed to analyse the prognostic relevance of microsatellite instability (MSI) in 241 colon and 90 rectal tumours, using a mononucleotide loci multiplex PCR assay and immunohistochemistry. Thirty (12.4%) colon tumours and one rectal tumour showed MSI. Although MSI was associated with proximal location and poor differentiation, no survival benefit was observed. The prognostic value of stage and differentiation was confirmed in this study. Analysis by stage revealed a longer overall (stage II/III) and disease free survival (stage II) for patients with well differentiated tumours. In addition, age and distal localisation were related to longer overall survival in stage II tumours. In conclusion, our findings show an association of MSI in sporadic colon tumours and certain clinical features; however, they do not suggest a survival benefit for MSI tumours.
authors: Laboratory of Cancer Research and Clinical Oncology, University of Antwerp (UA) and Department of Medical Oncology, University Hospital (UZA), Universiteitsplein 1, 2610 Wilrijk, Belgium. vanessa.deschoolmeester@ua.ac.be
authors: Vanessa
authors: V
authors: Deschoolmeester
authors: Nancy
authors: N
authors: Van Damme
authors: Marc
authors: M
authors: Baay
authors: Kathleen
authors: K
authors: Claes
authors: Eric
authors: E
authors: Van Marck
authors: Filip J
authors: FJ
authors: Baert
authors: Wim
authors: W
authors: Wuyts
authors: Marc
authors: M
authors: Cabooter
authors: Joost
authors: J
authors: Weyler
authors: Peter
authors: P
authors: Vermeulen
authors: Filip
authors: F
authors: Lardon
authors: Jan B
authors: JB
authors: Vermorken
authors: Marc
authors: M
authors: Peeters
mesh_terms: D000328:Adult; D000368:Aged; D002454:Cell Differentiation; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology; D053843:DNA Mismatch Repair; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D053842:Microsatellite Instability; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012004:Rectal Neoplasms / Q000235:genetics* / Q000473:pathology; D016019:Survival Analysis
chemical_list: D004273:DNA, Neoplasm