title: Pentylenetetrazole-induced status epilepticus following training does not impair expression of morphine-induced conditioned place preference.
abstract: Learning and memory play an important role in morphine addiction. Status epilepticus (SE) can impair the spatial and emotional learning and memory. However, little is known about the effects of SE on morphine-induced conditioned place preference (CPP). The present study was designed to investigate the effects of SE on morphine CPP, with food CPP being used as a control. The effects of SE on spatial memory in the Morris water maze (MWM) and Y-maze were investigated. SE was induced in adult mice using intraperitoneal injection of pentylenetetrazole; control mice received saline. The data indicated that SE had no effects on the formation of morphine CPP; however, the formation of food CPP was blocked by SE. Meanwhile, spatial memory assayed in the MWM and Y-maze was impaired by SE. In addition, the data demonstrated that SE did not cause a lasting disturbance of motor activity nor a change in the mice's appetite. These results suggested that although SE had no effects on morphine CPP, there was impaired food CPP and spatial memory in both the MWM and the Y-maze. The mechanisms underlying memory process of morphine CPP may be different from other types of memory.
authors: Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
authors: Jie
authors: J
authors: Zhang
authors: Hua
authors: H
authors: Tan
authors: Hai C
authors: HC
authors: Niu
authors: Jian H
authors: JH
authors: Wang
authors: Xiang D
authors: XD
authors: Tang
authors: Larry D
authors: LD
authors: Sanford
authors: Yuan-Ye
authors: YY
authors: Ma
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002755:Choice Behavior / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D004193:Discrimination Learning / Q000187:drug effects*; D018756:GABA Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000008:administration & dosage / Q000009:adverse effects*; D013226:Status Epilepticus / Q000139:chemically induced*
chemical_list: D000701:Analgesics, Opioid; D018756:GABA Antagonists; D009020:Morphine; D010433:Pentylenetetrazole