title: Plasmid-mediated quinolone resistance determinants qnrA, qnrB, and qnrS among clinical isolates of Enterobacteriaceae in a Korean hospital.
abstract: Screening of 368 consecutive nonreplicate clinical isolates of Enterobacteriaceae resistant to nalidixic acid and at least one extended-spectrum beta-lactam revealed the presence of qnrA, qnrB, and qnrS determinants, and identified novel qnrB variants, in Citrobacter freundii isolates. This study also revealed, for the first time, the linkage of qnrB, armA, and extended-spectrum and/or AmpC-type beta-lactamase genes on large conjugative plasmids.
authors: Department of Microbiology, Kyungpook National University School of Medicine, Jung-gu, Daegu, Republic of Korea.
authors: Migma Dorji
authors: MD
authors: Tamang
authors: Sung Yong
authors: SY
authors: Seol
authors: Jae-Young
authors: JY
authors: Oh
authors: Hee Young
authors: HY
authors: Kang
authors: Je Chul
authors: JC
authors: Lee
authors: Yoo Chul
authors: YC
authors: Lee
authors: Dong Taek
authors: DT
authors: Cho
authors: Jungmin
authors: J
authors: Kim
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000382:microbiology; D005798:Genes, Bacterial; D006785:Hospitals, University; D006801:Humans; D007723:Korea; D008969:Molecular Sequence Data; D015363:Quinolones / Q000494:pharmacology*; D011815:R Factors / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D017931:DNA Primers; D004269:DNA, Bacterial; D015363:Quinolones; D001618:beta-Lactamases