title: Comparison of anterior capsule contraction between 5 foldable intraocular lens models.
abstract: OBJECTIVE
  To compare anterior capsule contraction in cataract patients having implantation of 1 of 5 foldable intraocular lens (IOL) models and evaluate lens epithelial cell (LEC) adhesion to each model.
  
  
  METHODS
  Department of Ophthalmology, Dokkyo Medical University, Tochigi, Japan.
  
  
  METHODS
  This study comprised 115 patients (126 eyes) without systemic or ocular complications who had phacoemulsification with IOL implantation. The eyes were randomly assigned to receive 1 of the following IOLs: acrylic MA60BM (Alcon), SA60AT (Alcon), AR40e (Advanced Medical Optics), or YA-60BBR (Hoya) or a silicone AQ310NV (Canon). Two weeks and 1, 3, and 6 months postoperatively, the anterior capsule opening area was measured using an anterior segment analysis system (EAS-1000, Nidek) and the percentage of anterior capsule contraction was compared for each postoperative period and IOL. Cell adhesion to each IOL type was evaluated using LECs from albino rabbits.
  
  
  RESULTS
  The mean age of the patients was 73.6 years +/- 5.6 (SD). Eyes with the AQ310NV and AR40e IOLs had statistically significantly greater anterior capsule contraction. The rabbit study showed statistically significantly less LEC adhesion on these 2 IOL models.
  
  
  CONCLUSIONS
  Anterior capsule contraction was significantly greater with the AQ310NV and AR40e IOLs than with the other IOLs. Results indicate that cell adhesion to the IOL is an important factor in preventing anterior capsule contraction.
authors: Department of Ophthalmology, Dokkyo Medical University, 880 Kitakobayashi, Mibu City, Tochigi, Japan.
authors: Mayumi
authors: M
authors: Nagata
authors: Hiroyuki
authors: H
authors: Matsushima
authors: Koichiro
authors: K
authors: Mukai
authors: Wataru
authors: W
authors: Terauchi
authors: Norihito
authors: N
authors: Gotoh
authors: Eichiro
authors: E
authors: Matsui
mesh_terms: D000368:Aged; D000818:Animals; D000869:Anterior Eye Segment / Q000473:pathology; D002448:Cell Adhesion; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D007905:Lens Diseases / Q000209:etiology*; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular / Q000009:adverse effects*; D018918:Phacoemulsification; D011183:Postoperative Complications; D011817:Rabbits