[Folic acid fortification of bread recommendable].
Folic acid supplementation was recommended in the Netherlands after it had been demonstrated that periconceptional use of folic acid protected against foetal neural tube defects; this recommendation led to a slight decrease in prevalence only. According to the Dutch Health Council, fortification of bread should now be considered. Policy-making is complicated by uncertainties regarding potential side effects, such as adverse effects in children, for which scientific evidence is lacking however.
Cornel
M C
MC
VU Medisch Centrum, afd. Klinische Genetica, sectie Community Genetics/EMGO Instituut, Amsterdam. mc.cornel@vumc.nl
de Smit
D J
DJ
de Jong-van den Berg
L T W
LT
D004305:Dose-Response Relationship, Drug; D005492:Folic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D005494:Folic Acid Deficiency / Q000150:complications / Q000517:prevention & control*; D005527:Food, Fortified; D006801:Humans; D009426:Netherlands; D009436:Neural Tube Defects / Q000453:epidemiology / Q000517:prevention & control*; D009751:Nutritional Requirements; D011322:Primary Prevention; D014803:Vitamin B Complex / Q000008:administration & dosage* / Q000009:adverse effects
D014803:Vitamin B Complex; D005492:Folic Acid