title: Cytoskeleton mediated effective elastic properties of model red blood cell membranes.
abstract: The plasma membrane of human red blood cells consists of a lipid bilayer attached to a regular network of underlying cytoskeletal polymers. We model this system at a dynamic coarse-grained level, treating the bilayer as an elastic sheet and the cytoskeletal network as a series of phantom entropic springs. In contrast to prior simulation efforts, we explicitly account for dynamics of the cytoskeletal network, both via motion of the protein anchors that attach the cytoskeleton to the bilayer and through breaking and reconnection of individual cytoskeletal filaments. Simulation results are explained in the context of a simple mean field percolation model and comparison is made to experimental measurements of red blood cell fluctuation amplitudes.
authors: Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.
authors: Rui
authors: R
authors: Zhang
authors: Frank L H
authors: FL
authors: Brown
mesh_terms: D003599:Cytoskeleton / Q000378:metabolism*; D004058:Diffusion; D004548:Elasticity; D004910:Erythrocyte Membrane / Q000737:chemistry* / Q000378:metabolism*; D007700:Kinetics; D008958:Models, Molecular; D009010:Monte Carlo Method; D013049:Spectrin / Q000737:chemistry / Q000378:metabolism; D013500:Surface Tension
chemical_list: D013049:Spectrin