title: Highly regioselective synthesis of polysubstituted pyrroles through three-component reaction induced by low-valent titanium reagent.
abstract: 1,2,3,5-Tetrasubstituted and 1,2,3,4,5-pentasubstituted pyrroles may be synthesized through three-component reaction of 1,3-diketones, aldehydes, and amines induced by low-valent titanium reagent. High regioselectivity was achieved. Compared with the classical synthetic method, this new method has the advantages of short reaction time (15 min), high yields, convenient manipulation, and high regioselectivity.
authors: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215123, P. R. China.
authors: Guolan
authors: G
authors: Dou
authors: Chunling
authors: C
authors: Shi
authors: Daqing
authors: D
authors: Shi
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D007202:Indicators and Reagents; D007659:Ketones / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis*; D014025:Titanium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000588:Amines; D007202:Indicators and Reagents; D007659:Ketones; D011758:Pyrroles; D014025:Titanium