title: [Coexistence of two germinal cell tumors, seminomatous and nonseminomatous, with an uncommon clinical presentation].
abstract: OBJECTIVE
  The existence of non seminomatous mixed germ cell tumors of the testis is a frequent event in urologic oncology. Nevertheless, the presence of both components, seminomatous and non seminomatous, in a germ cell tumor is unusual.
  
  
  METHODS
  We present a case of pure classic seminoma of the testis with a lymph node metastasis of pure embryonal carcinoma, with confirmatory immuohistochemical study and clinical outcome of the patient.
  
  
  RESULTS
  A 34-year-old man presented with 3 cm supraclavicular tumor. CT scan also revealed multiple metastases in lymph nodes, liver, kidney and left adrenal gland. Tumor markers were negative and the biopsy performed discovered a lymph node metastasis of embryonal carcinoma of probable testicular origin. Ultrasound revealed a 6 mm hypoechoic nodule in the right testis. Orchyectomy was performed and pathologic analysis demonstrated a tumor, 1 cm of diameter, histopathologically compatible with classical seminoma with pagetoid extension to rete testis. Albuginea and spermatic cord did not present neoplastic involvement. Currently the patient is being treated with chemotherapy.
  
  
  CONCLUSIONS
  The interest of the case is to remark an unusual aggressive clinical presentation as well as to perform a bibliographic review with emphasis in the theories regarding heterogeneous differentiation and spontaneous regression of germ cell tumors of the testis.
authors: Departamento de Anatomía Patológica, Hospital Clínico Universitario de Valencia, Valencia, España. pilarsoriano10@yahoo.es
authors: Pilar
authors: P
authors: Soriano Sarrió
authors: Isabel
authors: I
authors: Chirivella
authors: Samuel
authors: S
authors: Navarro Fos
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D013736:Testicular Neoplasms / Q000473:pathology*