title: Synthesis of functionalized amino acid derivatives as new pharmacophores for designing anticancer agents.
abstract: A new series of functionalized amino acid derivatives N-substituted 1-N-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyl-5-oxazolidine carboxamide (1-17) and 1-N-substituted-3-amino-2-hydroxy-3-phenylpropane-1-carboxamide (18-34) were synthesized and evaluated for their in vitro cytotoxicity against human cancer cell lines. Compound 6 has shown interesting cytotoxicity (IC(50) = 5.67 microm) in ovarian cancer, while compound 10 exhibited promising cytotoxicity in ovarian (IC(50) = 6.1 microm) and oral (IC(50) = 4.17 microm) cancers. These compounds could be of use in designing new anti-cancer agents.
authors: Chemical Research, Dabur Research Foundation, 22, Site IV, SahibabadGhaziabad, 201 010, UP, India. kumarv@dabur.com
authors: Vivek
authors: V
authors: Kumar
authors: Mukesh M
authors: MM
authors: Mudgal
authors: Nidhi
authors: N
authors: Rani
authors: Amrita
authors: A
authors: Jha
authors: Manu
authors: M
authors: Jaggi
authors: Anu T
authors: AT
authors: Singh
authors: Vinod K
authors: VK
authors: Sanna
authors: Pratibha
authors: P
authors: Singh
authors: Pramod K
authors: PK
authors: Sharma
authors: Raghuveer
authors: R
authors: Irchhaiya
authors: Anand C
authors: AC
authors: Burman
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000596:Amino Acids / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009062:Mouth Neoplasms / Q000473:pathology; D010051:Ovarian Neoplasms / Q000473:pathology
chemical_list: D000577:Amides; D000596:Amino Acids; D000970:Antineoplastic Agents