Genetic interactions model among Eotaxin gene polymorphisms in asthma.
Eotaxin family (Eotaxin 1,2 and 3) recruits and activates CCR3-bearing cells such as eosinophil, mast cells, and Th2 lymphocytes that play a major role in allergic disorders. We examined the polygenetic effects of the Eotaxin gene family in a Korean population. Gene-gene interactions were tested using a multistep approach with multifactor dimensionality reduction (MDR) method between asthmatics and normal controls. The overall best MDR model of the main effect single nucleotide polymorphisms (SNPs) included EOT2 + 1272A > G and EOT3 + 77C > T (model 1) [testing accuracy 0.597, cross-validation consistency (CVC) 10/10, P < 0.001]. The overall best MDR model of the SNPs with no main effects included EOT2 + 304C > A, EOT3 + 716A > G, and EOT3 + 1579G > A (model 2) (testing accuracy 0.616, CVC 10/10, P < 0.001). Model 3 was obtained by including the MDR variables for models 1 and 2. This new composite model predicted asthma with better accuracy than either model 1 or model 2 (testing accuracy 0.643, CVC 10/10, P < 0.001). The detection of statistical interaction models is one evidence of gene-gene interactions among Eotaxin genes, and this interaction is thought to influence the development of asthma. Although the models are limited to determining statistical interactions within a population, they may be useful for identifying groups at high risk of developing asthma.
Lee
June-Hyuk
JH
Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Genome Research Center for Allergy and Respiratory Diseases, SoonChunHyang University Bucheon Hospital, 1174, Joong Dong, Wonmi Gu, Bucheon Si, Gyeonggi Do, 420-021, South Korea.
Moore
Jason H
JH
Computational Genetics, Dartmouth Medical School, 706 Rubin Building HB 7937, One Medical Center Drive, Lebanon, NH, 03756, USA.
Park
Sung-Woo
SW
Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Genome Research Center for Allergy and Respiratory Diseases, SoonChunHyang University Bucheon Hospital, 1174, Joong Dong, Wonmi Gu, Bucheon Si, Gyeonggi Do, 420-021, South Korea.
Jang
An-Soo
AS
Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Genome Research Center for Allergy and Respiratory Diseases, SoonChunHyang University Bucheon Hospital, 1174, Joong Dong, Wonmi Gu, Bucheon Si, Gyeonggi Do, 420-021, South Korea.
Uh
Soo-Taek
ST
Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Genome Research Center for Allergy and Respiratory Diseases, SoonChunHyang University Bucheon Hospital, 1174, Joong Dong, Wonmi Gu, Bucheon Si, Gyeonggi Do, 420-021, South Korea.
Kim
Yong Hoon
YH
Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Genome Research Center for Allergy and Respiratory Diseases, SoonChunHyang University Bucheon Hospital, 1174, Joong Dong, Wonmi Gu, Bucheon Si, Gyeonggi Do, 420-021, South Korea.
Park
Choon-Sik
CS
Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Genome Research Center for Allergy and Respiratory Diseases, SoonChunHyang University Bucheon Hospital, 1174, Joong Dong, Wonmi Gu, Bucheon Si, Gyeonggi Do, 420-021, South Korea. mdcspark@unitel.co.kr.
Park
Byung Lae
BL
Department of Genetic Epidemiology, SNP Genetics, Inc., 11th Floor, Mae Hun B/D, 13 Chongro 4Ga, Chongro-gu, Seoul, 110-834, South Korea.
Shin
Hyoung Doo
HD
Department of Genetic Epidemiology, SNP Genetics, Inc., 11th Floor, Mae Hun B/D, 13 Chongro 4Ga, Chongro-gu, Seoul, 110-834, South Korea.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D054413:Chemokine CCL11 / Q000235:genetics*; D054423:Chemokine CCL24 / Q000235:genetics*; D000075906:Chemokine CCL26; D019742:Chemokines, CC / Q000235:genetics*; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D005810:Multigene Family / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
C515456:CCL11 protein, human; C515484:CCL24 protein, human; C120429:CCL26 protein, human; D054413:Chemokine CCL11; D054423:Chemokine CCL24; D000075906:Chemokine CCL26; D019742:Chemokines, CC