[Effect of jieminqufeng decoction on cyclic nucleotides from the rats of allergic rhinitis].
OBJECTIVE
To observe the curative effect of Jieminqufeng decoction to the rats of allergic rhinitis and study the mechanism by which it treats allergic rhinitis.


METHODS
Forty wistar rats were divided into 4 groups at random. There are Jieminqufeng decoction group, cetirizine group, model control group and normal control group. The rats of allergic rhinitis were established with ovalbumin. We surveyed the behavioral changes of rats, searched eosinophilic granulocytes in the nasal secretion, detected the contents of cAMP and cGMP in the blood plasma and nasal mucosa.


RESULTS
The model control group had typical symptoms of allergic rhinitis and the eosinophilic granulocytes could be found more frequently. The contents of cAMP and cAMP/cGMP rose in the blood plasma and nasal mucosa (P < 0.01). However, the changes of jieminqufeng decoction group were small.


CONCLUSIONS
The jieminqufeng decoction is an effective drug to allergic rhinitis. Its possible mechanism is that it changes the contents of cAMP and cGMP, lessens inflammatory reaction and blocks up the allergy.
Huang
Yongjiu
Y
Department of Otolaryngology-Head and Neck Surgery, People's Hospital of Taizhou, Taizhou 225300, China. huangyongjiu99@yahoo.com.cn
Ma
Zhaoxin
Z
Huang
Ping
P
Li
Ming
M
Kuang
Xingwei
X
Kong
Xuhui
X
Bao
Xueli
X
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000242:Cyclic AMP / Q000032:analysis; D006152:Cyclic GMP / Q000032:analysis; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D008517:Phytotherapy; D051381:Rats; D017208:Rats, Wistar; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D000242:Cyclic AMP; D006152:Cyclic GMP