title: Bilateral infiltrative disease of the extraocular muscles: a rare clinical presentation of early stage chronic lymphocytic leukemia.
abstract: Orbital involvement in chronic lymphocytic leukemia (CLL) is highly unusual and most commonly involves hemorrhage or soft tissue infiltration in advanced disease. We report a case of rapid onset bilateral orbital muscle infiltration as the presenting feature of early stage CLL. In addition, we demonstrate clinico-pathological correlation with an identical chronic B-cell lymphocytic infiltrate in both orbit and bone marrow, with good response of the orbital disease to local radiotherapy.
authors: Moorfields Eye Hospital, London, United Kingdom.
authors: Yashin D
authors: YD
authors: Ramkissoon
authors: Richard W J
authors: RW
authors: Lee
authors: Rizwan
authors: R
authors: Malik
authors: James D
authors: JD
authors: Hsuan
authors: Mike J
authors: MJ
authors: Potts
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D003131:Combined Modality Therapy; D007839:Functional Laterality; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D017254:Leukemic Infiltration / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009801:Oculomotor Muscles / Q000187:drug effects / Q000473:pathology*; D009918:Orbital Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D011878:Radiotherapy
chemical_list: D015703:Antigens, CD; D005938:Glucocorticoids; D008775:Methylprednisolone