title: Soluble CD36 in plasma is increased in patients with symptomatic atherosclerotic carotid plaques and is related to plaque instability.
abstract: OBJECTIVE
  The risk for cardiovascular events is related to the composition and stability of an atherosclerotic plaque driven by inflammation and deposition of lipids. Scavenger receptors are a family of cell surface receptors involved in lipid uptake and inflammation. Recently, we found that soluble CD36 is increased in plasma from patients with diabetes strongly correlated with insulin resistance.
  
  
  METHODS
  We tested whether soluble CD36 is a marker of plaque stability in patients with high-grade internal carotid stenoses (n=62). The patients were classified according to plaque symptomatology and plaque echogenicity on ultrasound examination.
  
  
  RESULTS
  When patients were divided into 3 groups according to the latest clinical symptoms from plaques (ie, symptoms within the last 2 months [n=16], symptoms within the last 2 to 6 months [n=15], or asymptomatic [n=31]), the former group had significantly raised plasma levels of soluble CD36 as compared with the other 2 groups. In contrast, we found no differences in plasma levels of C-reactive protein, beta-thromboglobulin, lipid parameters, or HbA1C between these groups. The patients with echolucent carotid plaques (n=20) tended to have higher soluble CD36 levels in plasma compared with those with echogenic/heterogenic plaque (n=39; P=0.087). By immunohistochemistry, CD36 was localized to macrophages-rich area of intima within the atherosclerotic lesion.
  
  
  CONCLUSIONS
  We propose that sCD36 may be a marker of plaque instability and symptomatic carotid atherosclerosis, possibly at least partly as a result of CD36 release to the circulation from the foam cells within the atherosclerotic lesion.
authors: Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
authors: Aase
authors: A
authors: Handberg
authors: Mona
authors: M
authors: Skjelland
authors: Annika E
authors: AE
authors: Michelsen
authors: Ellen Lund
authors: EL
authors: Sagen
authors: Kirsten
authors: K
authors: Krohg-Sørensen
authors: David
authors: D
authors: Russell
authors: Arve
authors: A
authors: Dahl
authors: Thor
authors: T
authors: Ueland
authors: Erik
authors: E
authors: Oie
authors: Pål
authors: P
authors: Aukrust
authors: Bente
authors: B
authors: Halvorsen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D018955:CD36 Antigens / Q000097:blood*; D002340:Carotid Artery Diseases / Q000097:blood / Q000473:pathology; D016893:Carotid Stenosis / Q000097:blood / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D018955:CD36 Antigens