[Role of NF-kappaB in hematopoietic malignancies - review].
NF-kappaB is a kind of important nuclear factors which are relative to lots of cellular activities such as activation of immunocyte, development of T and B lymphocyte, stress reaction, cell apoptosis and so on. NF-kappaB exists in almost all types of cytoplasm in the unreactive form of heterodimer or homodimer. Recent studies have shown that there is close relationship between NF-kappaB and pathogenesis of hematopoietic malignancies such as leukemia, lymphoma and multiple myeloma. In this review, the advances of studies on the role of NF-kappaB in hematopoietic malignancies were summarized, including subunits of NF-kappaB and its activity, activity of NF-kappaB and its effect on apoptosis, activity of NF-kappaB in AML cells and its mechanism, activity of NF-kappaB in ATL cells and its mechanism, activity of NF-kappaB in lymphoma and its mechanism, activity of NF-kappaB in multiple myeloma cells and its mechanism, application of NF-kappaB suppression in hematopoietic malignancies and so on.
Chen
Cong
C
Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
Chen
Li
L
D017209:Apoptosis / Q000502:physiology*; D019337:Hematologic Neoplasms / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D006801:Humans; D016328:NF-kappa B / Q000276:immunology* / Q000378:metabolism
D016328:NF-kappa B