Macrocyclic nonviral vectors: high cell transfection efficiency and low toxicity in a lower rim guanidinium calix[4]arene.
New multivalent cationic lipids, one of them showing high efficiency and low toxicity in cell transfection, have been obtained by attaching guanidinium groups at the lower rim of calix[4]arenes.
Bagnacani
Valentina
V
Dipartimento di Chimica Organica e Industriale, Università di Parma, V.le G. P. Usberti 17/a, 43100 Parma, Italy.
Sansone
Francesco
F
Donofrio
Gaetano
G
Baldini
Laura
L
Casnati
Alessandro
A
Ungaro
Rocco
R
D047250:Calixarenes / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity*; D045744:Cell Line, Tumor; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004586:Electrophoresis; D019791:Guanidine / Q000737:chemistry*; D006801:Humans; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity*; D010714:Phosphatidylethanolamines / Q000378:metabolism; D014162:Transfection / Q000295:instrumentation* / Q000379:methods*
C410262:1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine; D010636:Phenols; D010714:Phosphatidylethanolamines; C121325:calix(4)arene; D047250:Calixarenes; D004247:DNA; D019791:Guanidine