title: The T244I variant of the interleukin-7 receptor-alpha gene and multiple sclerosis.
abstract: Several but not all studies have provided evidence for the association between multiple sclerosis (MS) and the T244I variant of the interleukin-7 receptor-alpha gene (IL7RA), rs6897932. We performed a new replication case-control study in 599 MS patients and 594 healthy controls, all Caucasians from the south of Spain. The genotype and allele frequencies differed between MS cases and controls. The IL7RA rs6897932 C allele and the CC genotype were found to be factors for disease susceptibility [per allele odds ratio (OR) 1.32, 95% CI 1.1-1.6, P=0.0031; per CC genotype vs TT + TC genotypes, OR 1.5, 95% CI 1.18-1.87, P=0.0007]. The combined data analysis included 3324 cases and 5032 controls of Europeans and Americans of European origin resulting in stronger association with similar OR (P=1.9 x 10E-9). These findings in our sample support previous reported association studies between IL7RA rs6897932 and MS.
authors: Instituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Científicas, Parque Tecnológico de Ciencias de la Salud, Granada, Spain.
authors: A
authors: A
authors: Alcina
authors: M
authors: M
authors: Fedetz
authors: D
authors: D
authors: Ndagire
authors: O
authors: O
authors: Fernández
authors: L
authors: L
authors: Leyva
authors: M
authors: M
authors: Guerrero
authors: C
authors: C
authors: Arnal
authors: C
authors: C
authors: Delgado
authors: F
authors: F
authors: Matesanz
mesh_terms: D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D053699:Interleukin-7 Receptor alpha Subunit / Q000235:genetics*; D007532:Isoleucine / Q000235:genetics; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D013030:Spain; D013912:Threonine / Q000235:genetics; D044465:White People / Q000235:genetics
chemical_list: D053699:Interleukin-7 Receptor alpha Subunit; D007532:Isoleucine; D013912:Threonine