title: The 3'UTR NFKBIA variant is associated with extensive colitis in Hungarian IBD patients.
abstract: OBJECTIVE
  In previous studies the NFKBIA 3'UTR (untranslated region) AA genotype was associated with Crohn's disease (CD), while the NFKB1-94ins/delATTG mutation increased the risk for ulcerative colitis (UC). The aim of our study was to investigate these two polymorphisms and patients' response to medical therapy and/or disease phenotype in Hungarian inflammatory bowel disease (IBD) patients.
  
  
  METHODS
  NFKBIA 3'UTR- and NFKB1-94ins/delATTG polymorphisms were investigated in 415 unrelated IBD patients (CD: 266 patients, mean age 35.2 +/- 12.1 years, duration 8.7 +/- 7.5 years; UC patients: 149, mean age 44.4 +/- 15.4 years, duration 10.7 +/- 8.9 years) and 149 controls by PCR-restriction fragment length polymorphism (RFLP) analysis. Detailed clinical phenotypes were determined by reviewing the medical charts.
  
  
  RESULTS
  The NFKBIA 3'UTR and NFKB1-94ins/delATTG genotypes and allele frequencies were not significantly different among IBD and controls. In patients with UC, the 3'UTR GG genotype was associated with extensive colitis (55.3 vs. 29.4%, odds ratio 2.97, 95% confidence interval 1.45-6.08). The presence of variant alleles did not predict response to steroids, infliximab, or need for surgery.
  
  
  CONCLUSIONS
  The NFKBIA 3'UTR GG genotype was associated with an increased risk for extensive colitis in Hungarian patients. In contrast, variant alleles did not predict response to medical therapy or need for surgery.
authors: 1st Department of Medicine, Semmelweis University, Koranyi st. 2/A, 1083, Budapest, Hungary.
authors: Tamas
authors: T
authors: Szamosi
authors: Peter Laszlo
authors: PL
authors: Lakatos
authors: Aniko
authors: A
authors: Szilvasi
authors: Laszlo
authors: L
authors: Lakatos
authors: Agota
authors: A
authors: Kovacs
authors: Tamas
authors: T
authors: Molnar
authors: Istvan
authors: I
authors: Altorjay
authors: Maria
authors: M
authors: Papp
authors: Orsolya
authors: O
authors: Szabo
authors: Anna
authors: A
authors: Satori
authors: Zsolt
authors: Z
authors: Tulassay
authors: Pal
authors: P
authors: Miheller
authors: Henrik Csaba
authors: HC
authors: Horvath
authors: Janos
authors: J
authors: Papp
authors: Attila
authors: A
authors: Tordai
authors: Hajnalka
authors: H
authors: Andrikovics
mesh_terms: D020413:3' Untranslated Regions; D000328:Adult; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006814:Hungary; D020672:I-kappa B Proteins; D054643:INDEL Mutation; D015212:Inflammatory Bowel Diseases / Q000235:genetics* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D000072000:NF-KappaB Inhibitor alpha; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D055815:Young Adult
chemical_list: D020413:3' Untranslated Regions; D004268:DNA-Binding Proteins; D020672:I-kappa B Proteins; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; C000606204:NFKBIA protein, human; D000072000:NF-KappaB Inhibitor alpha