title: The impact of duration of organ dysfunction on the outcome of patients with severe sepsis and septic shock.
abstract: OBJECTIVE
  This study aimed to assess the impact of the duration of organ dysfunction on the outcome of patients with severe sepsis or septic shock.
  
  
  METHODS
  Clinical data were collected from hospital charts of patients with severe sepsis and septic shock admitted to a mixed intensive care unit from November 2003 to February 2004. The duration of organ dysfunction prior to diagnosis was correlated with mortality. Results were considered significant if p<0.05.
  
  
  RESULTS
  Fifty-six patients were enrolled. Mean age was 55.6+/-20.7 years, mean APACHE II score was 20.6+/-6.9, and mean SOFA score was 7.9+/-3.7. Thirty-six patients (64.3%) had septic shock. The mean duration of organ dysfunction was 1.9+/-1.9 days. Within the univariate analysis, the variables correlated with hospital mortality were: age (p=0.015), APACHE II (p=0.008), onset outside the intensive care unit (p=0.05), blood glucose control (p=0.05) and duration of organ dysfunction (p=0.0004). In the multivariate analysis, only a duration of organ dysfunction persisting longer than 48 hours correlated with mortality (p=0.004, OR: 8.73 (2.37-32.14)), whereas the APACHE II score remained only a slightly significant factor (p=0.049, OR: 1.11 (1.00-1.23)). Patients who received therapeutic interventions within the first 48 hours after the onset of organ dysfunction exhibited lower mortality (32.1% vs. 82.1%, p=0.0001).
  
  
  CONCLUSIONS
  These findings suggest that the diagnosis of organ dysfunction is not being made in a timely manner. The time elapsed between the onset of organ dysfunction and initiation of therapeutic intervention can be quite long, and this represents an important determinant of survival in cases of severe sepsis and septic shock.
authors: Disciplina de Anestesiologia, Dor e Terapia Intensiva, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Flávio G R
authors: FG
authors: Freitas
authors: Reinaldo
authors: R
authors: Salomão
authors: Nathalia
authors: N
authors: Tereran
authors: Bruno Franco
authors: BF
authors: Mazza
authors: Murillo
authors: M
authors: Assunção
authors: Mirian
authors: M
authors: Jackiu
authors: Haggeas
authors: H
authors: Fernandes
authors: Flávia Ribeiro
authors: FR
authors: Machado
mesh_terms: D018806:APACHE; D017668:Age of Onset; D001786:Blood Glucose; D001938:Brazil / Q000453:epidemiology; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D012189:Retrospective Studies; D018805:Sepsis / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose