title: [Vitreous levels of stromal cell-derived factor-1 and vascular endothelial growth factor in diabetic retinopathy].
abstract: OBJECTIVE
  To investigate the levels of stromal cell-derived factor-1 (SDF-1) and vascular endothelial growth factor (VEGF) in the vitreous of patients with proliferative diabetic retinopathy.
  
  
  METHODS
  The levels of SDF-1 and VEGF in the vitreous of 30 eyes of 30 patients with proliferative diabetic retinopathy (PDR) and 12 eyes of 12 patients with idiopathic macular hole (MH) were measured by enzyme-linked immunosorbent assay. Vitreous fluid samples were obtained by vitrectomy.
  
  
  RESULTS
  The vitreous concentration of VEGF was significantly higher in eyes with PDR (2,865.87 +/- 387.85 pg/ml) than in eyes with idiopathic macular hole (142.42 +/- 21.03 pg/ml, P < 0.0001). The vitreous level of SDF-1 was also significantly higher in eyes with PDR (298.40 +/- 24.57 pg/ml) than in eyes with idiopathic macular hole (86.91 +/- 15.89 pg/ml, P < 0.0001). The vitreous concentration of SDF-1 correlated significantly with that of VEGF in eyes with PDR ([correlation coefficient] r = 0.62, P < 0.001).
  
  
  CONCLUSIONS
  Vitreous levels of both SDF-1 and VEGF in patients with PDR are significantly higher than those of nondiabetic patients. SDF-1 may be correlated with VEGF in angiogenesis in PDR.
authors: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
authors: Lingyan
authors: L
authors: Chen
authors: Lin
authors: L
authors: Lü
authors: Yonghao
authors: Y
authors: Li
authors: Xinhua
authors: X
authors: Huang
authors: Jinglin
authors: J
authors: Zhang
authors: Shiyi
authors: S
authors: Li
mesh_terms: D054377:Chemokine CXCL12 / Q000378:metabolism*; D003930:Diabetic Retinopathy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D014822:Vitreous Body / Q000378:metabolism* / Q000473:pathology
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A