title: Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid.
abstract: An efficient access to 2-isobetulin, 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid has been developed. The key step is a novel one-pot conversion of 2,3-dihydroxy triterpenes to 3-deoxy-2-oxo triterpenes. This method provides a new access to 3-deoxy-2-substituted pentacyclic triterpenes as potential therapeutic agents against metabolic diseases, tumors, and HIV infection.
authors: Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
authors: Jia
authors: J
authors: Hao
authors: Pu
authors: P
authors: Zhang
authors: Xiaoan
authors: X
authors: Wen
authors: Hongbin
authors: H
authors: Sun
mesh_terms: D008968:Molecular Conformation; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D053978:Pentacyclic Triterpenes; D013237:Stereoisomerism; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D000094062:Betulinic Acid; D000097245:Ursolic Acid
chemical_list: D009828:Oleanolic Acid; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D000094062:Betulinic Acid; D000097245:Ursolic Acid