title: Pulmonary emphysema: size distribution of emphysematous spaces on multidetector CT images--comparison with macroscopic and microscopic morphometry.
abstract: OBJECTIVE
  To test the hypothesis that the frequency-size distribution of low-attenuation areas could be a parameter to quantify pulmonary emphysema.
  
  
  METHODS
  Ethics committee approval and written informed consent were obtained. Multidetector computed tomographic (CT) scans were performed with simultaneous acquisition of four 1-mm sections of the whole chest in 80 patients (57 men, 23 women; age range, 38-79 years) who were referred for surgical resection of lung cancer. From the raw data, 1.25-mm-thick sections were reconstructed at 10-mm intervals. The relative area of lung with attenuation coefficients lower than -960 HU (RA(960)) and the 1st percentile of the distribution of attenuation coefficients were calculated. The cumulative frequency-size distributions of the RA(960) and the 1st percentile, when represented on a log-log plot, followed linear relationships. The slopes of these lines (D(960) and D(p1)) were compared with areas found macroscopically to have emphysema and with two different microscopic measurements assessed on resected specimens. Spearman correlation coefficients of each CT index with macroscopic and microscopic measurements were calculated.
  
  
  RESULTS
  The RA(960) and the 1st percentile showed statistically significant correlations with macroscopic and microscopic indexes (P < .001), whereas D(960) and D(p1) did not (P > or = .165).
  
  
  CONCLUSIONS
  The RA(960) and the 1st percentile reflect the extent of emphysema as compared to macroscopic and microscopic measurements, while D(960) and D(p1) do not.
authors: Department of Radiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. afarine@ladner-madani.com
authors: Afarine
authors: A
authors: Madani
authors: Alain
authors: A
authors: Van Muylem
authors: Viviane
authors: V
authors: de Maertelaer
authors: Jacqueline
authors: J
authors: Zanen
authors: Pierre Alain
authors: PA
authors: Gevenois
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging* / Q000473:pathology*; D011856:Radiographic Image Enhancement / Q000295:instrumentation / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*