[PPAR alpha-L162V, frequency and relationship with type 2 diabetes among black Senegalese people].
PPARs are supposed to be involved in pathogenesis of diabetes and its complications. According to some authors, L162V PPARalpha gene polymorphism would be associated to dyslipidemia susceptibility during diabetes, whereas for some authors, it rather would confer resistance to these metabolic abnormalities. The aim of this study is to search the relationship between this polymorphism and the occurrence of diabetes and its complications within a Senegalese black population constituted of 261 diabetic and 128 controls, by comparing alleles frequencies. Genomic analysis for alleles identification has been performed by the allelic discrimination technic TaqMan 5' Nuclease, after DNA extraction (Nucleon Bacc2. Amersham Int.). The results of genetic variants analysis revealed that L162V PPARalpha polymorphism would not be present among Senegalese black population, and consequently, should not be involved in diabetes onset.
Lopez-Sall
P
P
Laboratoire de biochimie pharmaceutique, Université Cheikh Anta Diop (UCAD), Dakar, Sénégal. plsall@yahoo.fr
Bard
J M
JM
Nazih
H
H
Cissé
A
A
Bobin-Dubigeon
C
C
Sall
N D
ND
D044383:Black People; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D006801:Humans; D047493:PPAR alpha / Q000235:genetics*; D011110:Polymorphism, Genetic; D012675:Senegal
D047493:PPAR alpha