[Histone specific proteinase and DNase activity of spleen lymphocyte nuclei during oncogenesis and under the effect of hydrobromide-5-(5',6' benzocoumaroyl-3')-methylaminouracil].
The features of histone proteolysis, their carbonylation level and endonucleolysis intensity were studied in the spleen lymphocytes of rats with transplanted Guerin's carcinoma and under the conditions of hydrobromide-5-(5',6' benzocoumaroyl-3')-methylaminouracil (BCU) action. The intensification of oxidizing histone destruction and histone-specific protease activity during oncogenesis and under conditions of BCU action was shown. DNase I and DNase II enzymatic activities of spleen lymphocytes of rats with tumour were decreased on different stages of tumour development, however, they were increased under conditions of chemical compound administration.
Kopyl'chuk
H P
HP
Marchenko
M M
MM
Iakovyshyn
H V
HV
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002467:Cell Nucleus / Q000187:drug effects* / Q000201:enzymology; D003851:Deoxyribonucleases / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism*; D005260:Female; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D051381:Rats; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D014498:Uracil / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
C520473:5-(5',6'-benzocoumarin-3')-methylaminouracil hydrobromide; D000970:Antineoplastic Agents; D014498:Uracil; D003851:Deoxyribonucleases; D010450:Endopeptidases; C021361:histone proteases