Synthesis, characterization and antibacterial activity of some triazole Mannich bases carrying diphenylsulfone moieties.
A series of Mannich bases of 4-substituted 5-[4-(4-X-phenylsulfonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-thiones, X=H, Cl, Br, 3 and 5 were synthesized and characterized on the basis of IR, NMR and elemental analyses. The potential antibacterial effects of the synthesized compounds were investigated using the Acinetobacter baumanii ATCC 19606; Citrobacter freundii ATCC 8090; Pseudomonas aeruginosa ATCC 9027; Enterococcus faecalis ATCC 19433; Staphylococcus aureus ATCC 12600; Staphylococcus epidermidis ATCC 14990; Bacillus subtilis ATCC 6633 strains. Some of them exhibited promising activities against A. baumanii and B. subtilis.
Almajan
Gabriela Laura
GL
Organic Chemistry Department, Faculty of Pharmacy, Bucharest, Romania. laura.almajan@gmail.com
Barbuceanu
Stefania-Felicia
SF
Almajan
Eva-Ruxandra
ER
Draghici
Constantin
C
Saramet
Gabriel
G
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D008352:Mannich Bases / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D013450:Sulfones / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D008352:Mannich Bases; D013450:Sulfones; D014230:Triazoles