Subsequent pregnancy outcomes in patients with molar pregnancy and persistent gestational trophoblastic neoplasia.
OBJECTIVE
To evaluate the subsequent reproductive outcomes in patients with complete and partial molar pregnancy and gestational trophoblastic neoplasia (GTN) at the New England trophoblastic Disease Center between June 1, 1965, and December 31, 2007.


METHODS
Questionnaires regarding subsequent pregnancies were mailed to all patients with current mailing addresses at the New England Trophoblastic Disease Center.


RESULTS
The subsequent reproductive outcomes in patients with complete and partial molar pregnancies and persistent GTN were in general the same as those in the general population. However, after an episode of molar pregnancy the incidence of molar pregnancy in a later gestation was approximately 1%. Additionally, after successful chemotherapy for GTN, the incidence of stillbirth was 1.4% in later pregnancies.


CONCLUSIONS
Patients with molar pregnancies and GTN should be reassured that they can in general expect a normal future reproductive outcome.
Garrett
Leslie A
LA
New England Trophoblastic Disease Center, Boston, MA, USA.
Garner
Elizabeth I O
EI
Feltmate
Colleen M
CM
Goldstein
Donald P
DP
Berkowitz
Ross S
RS
D005260:Female; D031901:Gestational Trophoblastic Disease / Q000453:epidemiology*; D006801:Humans; D006828:Hydatidiform Mole / Q000453:epidemiology; D008404:Massachusetts / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012042:Registries