title: Sepsis therapy: what's the best for the mitochondria?
abstract: It is suspected that mitochondrial dysfunction is a major cause of organ failure in sepsis and septic shock. A study presented in this issue of Critical Care revealed that liver mitochondria from pigs treated with norepinephrine during endotoxaemia exhibit greater in vitro respiratory activity. The investigators provide an elegant demonstration of how therapeutic interventions in sepsis may profoundly influence mitochondrial respiration, but many aspects of mitochondrial function in sepsis remain to be clarified.
authors: Florian
authors: F
authors: Wagner
authors: Peter
authors: P
authors: Radermacher
authors: Michael
authors: M
authors: Georgieff
authors: Enrico
authors: E
authors: Calzia
mesh_terms: D000818:Animals; D006801:Humans; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology / Q000627:therapeutic use; D018805:Sepsis / Q000378:metabolism* / Q000628:therapy*
chemical_list: D009638:Norepinephrine