SSAO/VAP-1 protein expression during mouse embryonic development.
SSAO/VAP-1 is a multifunctional enzyme depending on in which tissue it is expressed. SSAO/VAP-1 is present in almost all adult mammalian tissues, especially in highly vascularised ones and in adipocytes. SSAO/VAP-1 is an amine oxidase able to metabolise various endogenous or exogenous primary amines. Its catalytic activity can lead to cellular oxidative stress, which has been implicated in several pathologies (atherosclerosis, diabetes, and Alzheimer's disease). The aim of this work is to achieve a study of SSAO/VAP-1 protein expression during mouse embryogenesis. Our results show that SSAO/VAP-1 appears early in the development of the vascular system, adipose tissue, and smooth muscle cells. Moreover, its expression is strong in several epithelia of the sensory organs, as well as in the development of cartilage sites. Altogether, this suggests that SSAO/VAP-1 enzyme could be involved in the differentiation processes that take place during embryonic development, concretely in tissue vascularisation.
Valente
Tony
T
Departament de Bioquimica i Biologia Molecular, Institut de Neurociències, Facultat de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain. tonyvalente@gmail.com
Solé
Montse
M
Unzeta
Mercedes
M
D000273:Adipose Tissue / Q000196:embryology / Q000378:metabolism*; D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D000818:Animals; D015153:Blotting, Western; D002319:Cardiovascular System / Q000196:embryology / Q000378:metabolism; D002356:Cartilage / Q000196:embryology / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D047108:Embryonic Development / Q000502:physiology*; D007150:Immunohistochemistry; D051379:Mice; D009130:Muscle, Smooth / Q000196:embryology / Q000378:metabolism; D051381:Rats
D015815:Cell Adhesion Molecules; D006631:Amine Oxidase (Copper-Containing); C492678:semicarbazide-sensitive amine oxidase-vascular adhesion protein-1, mouse; C510433:vascular adhesion protein-1, rat