title: Obesity and pulmonary complications in critically injured adults.
abstract: BACKGROUND
  Pulmonary complications following injury significantly contribute to subsequent mortality. Obese patients have preexisting risk factors for pulmonary complications, and are at risk for these complications following elective surgery. Whether or not obesity contributes to pulmonary complications after critical injury is poorly understood.
  
  
  METHODS
  A secondary analysis of a prospective cohort study of critically injured adults requiring at least 48 h of intensive care was performed. Patients were classified into the following body mass index groups: < or = 18.5 kg/m2 (underweight); 18.5 to 24.9 kg/m2 (normal); 25 to 29.9 kg/m2 (overweight); 30.0 to 39.9 kg/m2 (obese); and > or = 40.0 kg/m2 (severely obese). Outcomes included the rates of ARDS and pneumonia, the placement of a tracheostomy tube, and in-hospital mortality rate.
  
  
  RESULTS
  A total of 1,291 patients were available for analysis, and 30% of these patients were classified as either obese or severely obese. The age-, gender-, and severity-adjusted rate of ARDS was lower in severely obese patients (odds ratio, 0.36; 95% confidence interval [CI], 0.13 to 0.99) compared to normal weight patients. The rates of pneumonia (37%), tracheostomy (10%), and in-hospital mortality (11%) did not differ among the groups. Despite no difference in pulmonary complications, the severely obese group had an ICU length of stay that was 4.8 days (95% CI, 1.8 to 7.7 days) longer than the normal weight group.
  
  
  CONCLUSIONS
  Obesity does not appear to be an independent risk factor for increased pulmonary complications after critical injury, but severely obese patients are likely to require longer ICU stays.
authors: Department of Surgery, Division of Trauma & Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN. Electronic address: lesly.dossett@vanderbilt.edu.
authors: Lesly A
authors: LA
authors: Dossett
authors: Department of Surgery, Division of Trauma & Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN.
authors: Daithi
authors: D
authors: Heffernan
authors: Department of Surgery, Division of Trauma & Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN.
authors: Michelle
authors: M
authors: Lightfoot
authors: Department of Surgery, Division of Trauma & Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN.
authors: Bryan
authors: B
authors: Collier
authors: Department of Surgery, Division of Trauma & Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN.
authors: Jose J
authors: JJ
authors: Diaz
authors: Department of Surgery, University of Virginia Health System, Charlottesville, VA.
authors: Robert G
authors: RG
authors: Sawyer
authors: Department of Surgery, Division of Trauma & Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN.
authors: Addison K
authors: AK
authors: May
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016001:Confidence Intervals; D016638:Critical Illness / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units; D008171:Lung Diseases / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000401:mortality; D016017:Odds Ratio; D011379:Prognosis; D011446:Prospective Studies; D015599:Trauma Severity Indices; D014481:United States / Q000453:epidemiology; D014947:Wounds and Injuries / Q000150:complications* / Q000175:diagnosis / Q000401:mortality