Slow-releasing paclitaxel in polytetrafluoroethylene/polylactide-co-glycolide laminate delays adjustment after strabismus surgery in rabbit model.
OBJECTIVE
To determine the usefulness of slow-releasing paclitaxelin polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate for delayed adjustable strabismus surgery.


METHODS
A prospective, masked-observer, controlled study was performed in 25 rabbits. Fifty rabbit eyes were divided randomly into three groups. After recession of the superior rectus muscle (SRM), a PTFE/PLGA laminate containing paclitaxel, PTFE alone, or physiologic saline was applied beneath and over the SRM in the PTFE/PLGA-paclitaxel group (group paclitaxel), the PTFE group (group PTFE), and the control group, respectively. Delayed adjustment was performed by a masked observer once on each SRM at 3 or 5 weeks after surgery. Adjustability, adjustment lengths, forces required, and adhesion degrees were evaluated.


RESULTS
In the control group, adjustment was impossible in any eye at 3 or 5 weeks after surgery. In group PTFE, adjustment was possible in 5 of 8 eyes at 3 weeks after surgery and in 5 of 10 eyes at 5 weeks after surgery. In group paclitaxel, adjustment was possible in 6 of 9 eyes and in 7 of 7 eyes at 3 and 5 weeks after surgery. On comparing adjustability, a significant difference was observed between group paclitaxel and the control group at 3 and 5 weeks after surgery (P = 0.016 and P = 0.001, respectively). A significant difference was observed between group paclitaxel and the control group (P = 0.003) in terms of adhesion between SRMs and sclera 5 weeks after surgery.


CONCLUSIONS
Slow-releasing paclitaxel in PTFE/PLGA was found to reduce adhesion and allowed delayed adjustment in most eyes for up to 5 weeks after surgery.
Choung
Ho-Kyung
HK
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Boramae Hospital, Seoul, Korea.
Jin
Su-Eon
SE
Lee
Min Joung
MJ
Kim
Chong-Kook
CK
Hwang
Jeong-Min
JM
D000818:Animals; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D019344:Lactic Acid; D009801:Oculomotor Muscles / Q000187:drug effects* / Q000601:surgery; D017239:Paclitaxel / Q000008:administration & dosage*; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D011817:Rabbits; D013285:Strabismus / Q000601:surgery*; D013536:Suture Techniques; D000267:Tissue Adhesions / Q000517:prevention & control; D050257:Tubulin Modulators / Q000008:administration & dosage*; D015348:Vision, Binocular
D003692:Delayed-Action Preparations; D050257:Tubulin Modulators; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011138:Polytetrafluoroethylene; D017239:Paclitaxel