Gender-related difference in left ventricular diastolic elastance during exercise in patients with diabetes mellitus.
BACKGROUND
Because the ratio of mitral inflow and annular velocity to stroke volume has been reported as an index of diastolic elastance (Ed), the hypothesis tested in the present study was that Ed during exercise would be more abnormal in female than in male patients with type 2 diabetes.


RESULTS
Ed was measured at rest and during graded supine bicycle exercise (25W, 3-min increments) in 53 patients (27 males, mean age 53+/-14 years) with type 2 diabetes and 53 age- and gender-matched controls. The patients with diabetes were divided into 2 groups by gender. Ed was not significantly different at rest between men and women, but was significantly higher during exercise in women than in men (25 W, 0.15+/-0.04 vs 0.20+/-0.07, p=0.009; 50 W, 0.16+/-0.05 vs 0.21+/-0.08, p=0.0175).


CONCLUSIONS
Left ventricular (LV) diastolic elastance is abnormal during exercise, but not at rest, in patients with diabetes without overt heart disease. Female gender was associated with increased LV stiffness during exercise among patients with type 2 diabetes.
Ha
Jong-Won
JW
Division of Cardiology, Yonsei University College of Medicine, Seoul, Republic of Korea. jwha@yuhs.ac
Lee
Hyun-Chul
HC
Park
Sungha
S
Choi
Eui-Young
EY
Seo
Hye-Sun
HS
Shim
Chi-Young
CY
Kim
Jin-Mi
JM
Ahn
Jeong-Ah
JA
Lee
Se-Wha
SW
Rim
Se-Joong
SJ
Oh
Jae K
JK
Chung
Namsik
N
D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004548:Elasticity; D015444:Exercise; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000503:physiopathology*; D012727:Sex Characteristics; D012737:Sex Factors; D013318:Stroke Volume