[The effect of operating time of PMX-DHP on decrease of platelets].
BACKGROUND
Recently, it is said that long-term PMX-DHP is beneficial for severe septic shock. Decrease in platelets, however, is one of the problems of PMX-DHP. We retrospectively examined the effect of operating time of PMX-DHP on decrease of platelets.


METHODS
Forty-nine subjects were divided into three subgroups by their operating times of PMX-DHP. In short (S) group, the operating time was below 4 hours, and the group comsisted of 13 subjects. Intermediate (I) group with operating time of 4-12 hours, had 15 subjects. And long (L) group with operating time of 12-24 hours, had 21 subjects. Rate of decrease of platelets was compared between these subgroups.


RESULTS
Decreased rate of platelets of each sub-group is as follows; S group showed 16.7 +/- 28.4%, I group showed 25.5 +/- 28.1%, and L group showed 23.7 +/- 30.3% respectively. And there were no significant differences between these subgroups.


CONCLUSIONS
Decreased rate of platelets was around 20% as previously reported and constant regardless of duration of operating times of PMX-DHP. Long-term PMX-DHP within 24 hours is practically safe in case of severe septic shock.
Ooishi
Kazushige
K
Department of Anesthesiology and Intensive Care Medicine, Beppu Medical Center, Ooita 874-0011.
Etou
Takashi
T
Koga
Satoko
S
Kawabe
Satoshi
S
Uno
Takahiro
T
D000368:Aged; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D008297:Male; D011112:Polymyxin B; D012189:Retrospective Studies; D012772:Shock, Septic / Q000628:therapy*; D013921:Thrombocytopenia / Q000209:etiology*; D013997:Time Factors
D011112:Polymyxin B