Acute generalized exanthematous pustulosis due to clindamycin.
Acute generalized exanthematous pustulosis (AGEP) is a rare skin eruption most commonly caused by medications. It is characterized by fever and the acute eruption of non-follicular pustules overlying erythrodermic skin. Histopathology shows subcorneal pustules with a background of dermal edema and spongiosis, leukocytoclastic vasculitis, perivascular eosinophils, and focal necrosis of keratinocytes. Three cases of clindamycin induced AGEP have been reported in the literature. A case of AGEP due to clindamycin is reported in a patient with numerous other drug allergies and without history of psoriasis. Presentation and treatment of AGEP are reviewed.
Sulewski
Ronald J
RJ
Resurrection Hospital, Chicago, IL, USA.
Blyumin
Marianna
M
Kerdel
Francisco A
FA
D000208:Acute Disease; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002981:Clindamycin / Q000009:adverse effects* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003875:Drug Eruptions / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D005076:Exanthema / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D035583:Rare Diseases; D018570:Risk Assessment; D012720:Severity of Illness Index; D017444:Skin Diseases, Papulosquamous / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D016896:Treatment Outcome
D002981:Clindamycin