Furan oligomers and beta-carbolines from terrestrial streptomycetes.
2,5-Bis(hydroxymethyl)furan monoacetate (3) and 2,5-bis(hydroxymethyl)furan diacetate (4) were obtained as new natural products from an ethyl acetate extract of the terrestrial Streptomyces sp. isolate GW11/1695. Another Streptomyces isolate, GW21/1313, delivered a dimer (6) and a trimer (7) of (hydroxymethyl)furfural. The latter strain also produced 4-hydroxy-2-(5-(hydroxymethyl)furan-2-ylmethylene)-5-methylfuran-3-one (5), perlolyrin (8), and two new beta-carboline derivatives, 9 and 10. 2,5-Bis(hydroxymethyl)furan diacetate (4) exhibited weak cytotoxic activity against brine shrimp larvae.
Fotso
Serge
S
Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Maskey
Rajendra P
RP
Schröder
Dirk
D
Ferrer
Anna S
AS
Grün-Wollny
Iris
I
Laatsch
Hartmut
H
D000818:Animals; D001156:Artemia / Q000187:drug effects; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry*
D005663:Furans