Simultaneous Doppler tracing of the mitral inflow and annular motion provides a useful means of evaluating left ventricular diastolic function.
BACKGROUND
In this study, we evaluated the feasibility and clinical usefulness of TS(E-E(') ), the time interval between the onsets of early diastolic mitral inflow velocity (E) and mitral annular velocity (E'), obtained by simultaneously tracing E and E', in terms of evaluating diastolic function.


METHODS
By the diastolic functional status, 105 patients were allocated to abnormal relaxation, pseudonormal filling (PN), or normal diastolic function groups (n = 30, 43, and 32, respectively). The TS(E-E(') ) was measured in the same cardiac cycle by the pulsed-wave Doppler (PWD) tracing of mitral inflow near the septal annulus with appropriate filter and gain settings.


RESULTS
TS(E-E(') ) was prolonged in the PN group versus the normal group (34.1 +/- 12.2 msec versus 12.1 +/- 8.5 msec, p< or =0.001). The area under the receiver operating characteristic curve of TS(E-E(') ) for the detection of PN was 0.91 (95% confidence interval [CI]; 0.85 approximately 0.97, p<0.001), and 24.0 msec was determined to be the optimal cut-off value (specificity 83.7%, sensitivity 90.3%).


CONCLUSIONS
Simultaneous measurement of TS(E-E(') ) is feasible and clinically applicable for the grading of diastolic dysfunction (DD).
Choi
Jin-Oh
JO
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Park
Seung Woo
SW
Shin
Dae-Hee
DH
Han
Hyejin
H
Cho
Sungwon
S
Kim
Jun Hyung
JH
Song
Young Bin
YB
Lee
Sang-Chol
SC
D003971:Diastole / Q000502:physiology*; D004452:Echocardiography; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging*; D012680:Sensitivity and Specificity; D016277:Ventricular Function, Left / Q000502:physiology*