title: Comorbidity in disease-free survivors of cervical cancer compared with the general female population.
abstract: OBJECTIVE
  We aimed to investigate the prevalence of comorbidities in cervical cancer survivors compared with the general population and to identify risk factors and impact on their quality of life (QoL).
  
  
  METHODS
  860 female cervical cancer survivors enrolled at six tertiary hospitals and 994 women from the general population were surveyed on current comorbidities and QoL (EORTC QLQ-C30 and QLQ-CX24).
  
  
  RESULTS
  Compared with the general female population, the cervical cancer survivors reported higher prevalence of comorbidities (0.93 +/- 2.91 vs. 0.37 +/- 0.67, p < 0.01), significantly more heart disease (adjusted odds ratio (aOR), 2.64; 95% confidence interval (CI), 1.38-5.07), liver disease (aOR, 3.29; 95% CI, 1.54-7.02), hypertension (aOR, 1.72; 95% CI, 1.30-2.27), gastrointestinal disease (aOR, 1.79; 95% CI, 1.37-2.33) and musculoskeletal disease (aOR, 1.94; 95% CI, 1.45-2.59). Heart and renal disease significantly influenced QoL in many subscales. Patients with diabetes or cerebrovascular disease had an increased likelihood of sexual problems.
  
  
  CONCLUSIONS
  The cervical cancer survivors had more comorbidities than the general population, and that in turn affected their QoL. Vigilant follow-up of comorbidities should be incorporated into in the care of cancer survivors.
authors: National Cancer Control Research Institute and Hospital, National Cancer Center, Goyang, Korea.
authors: Dong Wook
authors: DW
authors: Shin
authors: Joo Hyun
authors: JH
authors: Nam
authors: Yong Chul
authors: YC
authors: Kwon
authors: Sang Yoon
authors: SY
authors: Park
authors: Duk-Soo
authors: DS
authors: Bae
authors: Chong Taik
authors: CT
authors: Park
authors: Chi-Heum
authors: CH
authors: Cho
authors: Jong Min
authors: JM
authors: Lee
authors: Sang Min
authors: SM
authors: Park
authors: Young Ho
authors: YH
authors: Yun
mesh_terms: D016022:Case-Control Studies; D015897:Comorbidity; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D011788:Quality of Life; D012307:Risk Factors; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D017741:Survivors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000628:therapy