title: Playing by different rules: the evolution of virulence in sterilizing pathogens.
abstract: We investigate the evolution of virulence of pathogens that reduce their hosts' fitness primarily by affecting host fecundity. We show that, under many conditions, such sterilizing pathogens evolve high rather than intermediate levels of virulence, and this pushes the pathogen population and sometimes the host population toward extinction. We also show that spatial population structure can reverse this evolutionary result and allow the persistence of intermediate-virulence pathogens. Thus, spatial population structure may be vital to the persistence of sterilizing pathogens in nature.
authors: Department of Biology, Duke University, Durham, North Carolina 27708, USA.
authors: Kara J
authors: KJ
authors: O'Keefe
authors: Janis
authors: J
authors: Antonovics