title: Effect of cement dust exposure on phagocytic function of polymorphonuclear neutrophils in cement mill workers.
abstract: OBJECTIVE
  Exposure to cement dust can cause various occupational health problems due to its increasing incidence and long-term complications. However, the influence of cement dust on phagocytic function of polymorphonuclear neutrophils (PMNs), has not as yet been investigated. Therefore, the aim of the study was to measure the phagocytic activity of PMNs by assessing chemilumiscence (CL) response in cement mill workers and controls.
  
  
  METHODS
  In this study, 50 volunteer males, aged 25-60 years, apparently healthy and nonsmoking, were randomly selected from among cement mill workers. These workers were further classified into subgroups based on exposure duration of less than 10, 10-20, and more than 20 years. The controls were 50 healthy, nonsmoking, males who matched the study group with respect to age, height, weight, and socioeconomic status. The phagocytic function of PMNs, stimulated with opsonized zymosan, was determined by measuring CL response.
  
  
  RESULTS
  The findings show a significant decrease in phagocytic activity of PMNs [PMNs OPZ p < 0.005] in cement mill workers compared to controls.
  
  
  CONCLUSIONS
  It is concluded that exposure to cement dust can impair the phagocytic function of PMNs which is reflected in decreased chemiluminescence response.
authors: Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. sultanmeo@hotmail.com
authors: Sultan Ayoub
authors: SA
authors: Meo
authors: Shahzad
authors: S
authors: Rasheed
authors: Muhammad Mujahid
authors: MM
authors: Khan
authors: Syed
authors: S
authors: Shujauddin
authors: Ali S
authors: AS
authors: Al-Tuwaijri
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000506:poisoning*; D016022:Case-Control Studies; D002617:Chemical Industry; D003252:Construction Materials / Q000506:poisoning*; D004391:Dust; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects*; D009784:Occupational Diseases / Q000097:blood* / Q000209:etiology; D016273:Occupational Exposure / Q000009:adverse effects*
chemical_list: D000395:Air Pollutants, Occupational; D004391:Dust