A simple reaction kinetic model of rapid (G protein dependent) and slow (beta-Arrestin dependent) transmission.
In this paper the qualitative dynamic behavior of reaction kinetic models of G protein signaling is examined. A simplified basic G protein signaling structure is defined, which is extended to be able to take the effect of slow transmission, RGS mediated feedback regulation and ERK-phosphatase mediated feedback regulation into account. The resulting model gives rise to an acceptable qualitative approximation of the G protein dependent and independent ERK activation dynamics that is in good agreement with the experimentally observed behavior.
Csercsik
Dávid
D
Process Control Research Group, Systems and Control Laboratory, Computer and Automation Research Institute, Hungarian Academy of Sciences, P.O. Box 63, H-1518 Budapest, Hungary. csercsik@scl.sztaki.hu
Hangos
Katalin M
KM
Nagy
György M
GM
D000818:Animals; D019390:Arrestins / Q000378:metabolism*; D003198:Computer Simulation; D025461:Feedback, Physiological; D019204:GTP-Binding Proteins / Q000378:metabolism*; D020935:MAP Kinase Signaling System / Q000502:physiology*; D008954:Models, Biological; D008956:Models, Chemical; D010766:Phosphorylation; D000071557:beta-Arrestins
D019390:Arrestins; D000071557:beta-Arrestins; D019204:GTP-Binding Proteins