An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia: a multi-center study of 381 patients.
In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impact has been controversial. Cytogenetic data from 381 patients diagnosed with B-precursor acute lymphoblastic leukemia were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9;22)/BCR-ABL. Patients with abnormalities of chromosome 9 showed significantly shorter overall survival compared with patients with normal karyotypes. In fact, overall survival was similar to that in the poor prognosis t(9;22)/BCR-ABL-positive group. Our data suggest that chromosomal abnormalities involving 9p may have a significant negative impact on survival in adult B-precursor acute lymphoblastic leukemia.
Nahi
Hareth
H
Haematology Centre, Karolinska University Hospital Huddinge,141 86 Stockholm, Sweden. hareth.nahi@karolinska.se
Hägglund
Hans
H
Ahlgren
Thomas
T
Bernell
Per
P
Hardling
Mats
M
Karlsson
Karin
K
Lazarevic
Vladimir Lj
VLj
Linderholm
Mats
M
Smedmyr
Bengt
B
Aström
Maria
M
Hallböök
Helene
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D002051:Burkitt Lymphoma / Q000097:blood / Q000145:classification / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007958:Leukocyte Count; D008875:Middle Aged; D011379:Prognosis; D017384:Sequence Deletion; D016019:Survival Analysis; D014178:Translocation, Genetic; D014944:World Health Organization
D005819:Genetic Markers