Acute superior oblique palsy in the monkey: effects of viewing conditions on ocular alignment and modelling of the ocular motor plant.
We investigated the immediate and long-term changes in static eye alignment with acute superior oblique palsy (SOP) in the monkey. When the paretic eye was patched immediately after the lesion for 6-9 days, vertical alignment slowly improved. When the patch was removed and binocular viewing was allowed, alignment slowly worsened. In contrast when a monkey was not patched immediately after the lesion vertical alignment did not improve. We also show that a model of the eye plant can reproduce the observed acute deficit induced by SOP, but only by abandoning Robinson's symmetric simplification of the reciprocal innervation relationship within pairs of agonist-antagonist muscles. The model also demonstrated that physiologic variability in orbital geometry can have a large impact on SOP deficits.
Quaia
Christian
C
Laboratory of Sensorimotor Research, National Eye, Institute, Bethesda, MD, USA.
Shan
Xiaoyan
X
Tian
Jing
J
Ying
Howard
H
Optican
Lance M
LM
Walker
Mark
M
Tamargo
Rafael
R
Zee
David S
DS
D000818:Animals; D003290:Convergence, Ocular / Q000502:physiology; D005133:Eye Movements / Q000502:physiology*; D005403:Fixation, Ocular / Q000502:physiology; D000882:Haplorhini; D006801:Humans; D008954:Models, Biological; D013285:Strabismus / Q000503:physiopathology*; D020432:Trochlear Nerve Diseases / Q000503:physiopathology*; D015348:Vision, Binocular / Q000502:physiology*