A new class of functionalized polyoxometalates: synthesis, structure and preliminary antitumor activity studies of three arylimido substituted hexamolybdates bearing a strong electron-withdrawing nitro group, (Bu4N)2[Mo6O18([triple bond]NAr)] (Ar = 3-NO2-C6H4, 2-CH3-4-NO2-C6H3, 2-CH3-5-NO2-C6H3).
Three novel mono-functionalized arylimido derivatives of hexamolybdate bearing the strongest electron-withdrawing nitro group, (Bu(4)N)(2)[Mo(6)O(18)([triple bond]NAr)] (1, 2 and 3), have been synthesized for the first time by an improved reaction of octamolybdate ion and 3-nitroaniline hydrochloride, 2-methyl-4-nitroaniline hydrochloride and 2-methyl-5-nitroaniline hydrochloride respectively with DCC (N,N'-dicyclohexylcarbodiimide) as a dehydrating agent. Complete assignments were achieved for the title compounds by elemental analysis, IR, (1)H NMR, UV/visible and single-crystal X-ray diffraction analyses. The preliminary antitumor activity test indicated that the title compounds have some effects on the cellular growth inhibition of K562 cells.
Xue
Sijia
S
Department of Chemistry, Shanghai Normal University, Shanghai, China. sjxue@sohu.com
Chai
An
A
Cai
Zhijuan
Z
Wei
Yongge
Y
Xiang
Changsheng
C
Bian
Wangdong
W
Shen
Jian
J
D000814:Aniline Compounds / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D004024:Dicyclohexylcarbodiimide / Q000737:chemistry; D015195:Drug Design; D004583:Electrons; D006801:Humans; D007094:Imides / Q000737:chemistry*; D020014:K562 Cells; D008958:Models, Molecular; D008968:Molecular Conformation; D008982:Molybdenum / Q000737:chemistry*; D009574:Nitro Compounds / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011108:Polymers / Q000737:chemistry*; D013057:Spectrum Analysis; D017973:Tungsten Compounds / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D000814:Aniline Compounds; D000970:Antineoplastic Agents; D007094:Imides; D009574:Nitro Compounds; D009942:Organometallic Compounds; D011108:Polymers; D017973:Tungsten Compounds; D014867:Water; C044659:molybdate; D004024:Dicyclohexylcarbodiimide; D008982:Molybdenum; C023650:aniline