title: Influence of pre-systemic modifications on the drug performance.
abstract: Influences of technological and other pre-systemic modifications on the drug performance play a pivotal role in drug development and optimization. The paper evaluates these influences within a framework of the sensitivity theory. Deviations of the drug performance that were caused by modified pre-systemic parameters are predicted and compared with those obtained in vivo. A close correspondence between them demonstrates feasibility of the approach presented and its usability as an alternative or suplementary means of the in vitro-in vivo correlation analysis.
authors: Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.
authors: Z
authors: Z
authors: Vitková
authors: J
authors: J
authors: Oremusová
authors: A
authors: A
authors: Vitko
mesh_terms: D000465:Algorithms; D002626:Chemistry, Pharmaceutical / Q000592:standards*; D003198:Computer Simulation; D004339:Drug Compounding; D015233:Models, Statistical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010599:Pharmacokinetics
chemical_list: D004364:Pharmaceutical Preparations