title: Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease.
abstract: Increases in the incidence and severity of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have spawned efforts to define unique virulence properties among prevalent strains. Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention because of its epidemiologic association with CA-MRSA. Using both the clinical isolate LAC, which is representative of the epidemic USA300 strain, and its isogenic PVL-negative strain in murine models of staphylococcal skin infection and pneumonia, we expanded upon recent studies by assessing the contribution of PVL in the genetic background of BALB/c mice. The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice.
authors: Department of Microbiology, University of Chicago, Chicago, Illinois, USA.
authors: Juliane
authors: J
authors: Bubeck Wardenburg
authors: Amy M
authors: AM
authors: Palazzolo-Ballance
authors: Michael
authors: M
authors: Otto
authors: Olaf
authors: O
authors: Schneewind
authors: Frank R
authors: FR
authors: DeLeo
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000235:genetics / Q000378:metabolism; D017714:Community-Acquired Infections / Q000382:microbiology / Q000473:pathology*; D004195:Disease Models, Animal; D005098:Exotoxins / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D007956:Leukocidins / Q000235:genetics / Q000378:metabolism; D016106:Methicillin Resistance; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D011023:Pneumonia, Staphylococcal / Q000382:microbiology / Q000401:mortality / Q000473:pathology*; D013207:Staphylococcal Skin Infections / Q000382:microbiology / Q000473:pathology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D014774:Virulence
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin