title: Short-term clinical effects of adjunctive antimicrobial photodynamic therapy in periodontal treatment: a randomized clinical trial.
abstract: OBJECTIVE
  The aim of this study was to assess the effect of adjunctive antimicrobial photodynamic therapy (aPDT) in chronic periodontitis.
  
  
  METHODS
  Twenty patients with untreated chronic periodontitis were included. All teeth received periodontal treatment comprising scaling and root planing. Using a split-mouth design, two quadrants (test group) were additionally treated with aPDT. Sulcus fluid flow rate (SFFR) and bleeding on probing (BOP) were assessed at baseline, 1 week and 3 months after treatment. Relative attachment level (RAL), probing depths (PDs) and gingival recession (GR) were evaluated at baseline and 3 months after treatment.
  
  
  RESULTS
  Baseline median values for PD, GR and RAL were not different in the test group and control group. Values for RAL, PD, SFFR and BOP decreased significantly 3 months after treatment in the control group (median delta RAL: -0.35 mm, inter-quartile range: 0.21 mm), with a higher impact on the sites treated with adjunctive aPDT (median delta RAL: -0.67 mm, inter-quartile range: 0.36 mm, p<0.05). GR increased 3 months after treatment with and without adjunctive aPDT (p<0.05), with no difference between the groups (p>0.05).
  
  
  CONCLUSIONS
  In patients with chronic periodontitis, clinical outcomes of conventional subgingival debridement can be improved by adjunctive aPDT.
authors: Department of Periodontology, Operative and Preventive Dentistry, University Dental Clinic Bonn, Welschnonnenstrasse 17, D-53111 Bonn, Germany. andreas.braun@uni-bonn.de
authors: Andreas
authors: A
authors: Braun
authors: Claudia
authors: C
authors: Dehn
authors: Felix
authors: F
authors: Krause
authors: Søren
authors: S
authors: Jepsen
mesh_terms: D000328:Adult; D055113:Chronic Periodontitis / Q000150:complications / Q000188:drug therapy*; D003131:Combined Modality Therapy; D003741:Dental Deposits / Q000150:complications / Q000517:prevention & control*; D012534:Dental Scaling; D005260:Female; D005881:Gingiva / Q000528:radiation effects; D006801:Humans; D028022:Low-Level Light Therapy / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000150:complications / Q000188:drug therapy; D010512:Periodontal Index; D010640:Phenothiazines / Q000627:therapeutic use; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D010640:Phenothiazines; D017319:Photosensitizing Agents; C031637:phenothiazine