Immunomodulatory effects of Caulerpa racemosa var peltata polysaccharide and its selenizing product on T lymphocytes and NK cells in mice.
A polysaccharide, CrvpPS, was isolated from Caulerpa racemosa var peltata. It was reacted with nano-selenium in distilled water containing ascorbic acid (Vit C) to form a stable CrvpPS-nano-Se complex. The immunomodulatory effects of CrvpPS and CrvpPS-nano-Se on T lymphocytes subgroups and NK cells in mice were investigated. After intragastric administration for 10 days separately, both CrvpPS and CrvpPS-nano-Se showed significant stimulatory functions to thymus gland of mice. Moreover, the CrvpPS-nano-Se induced the percentage of CD3+, CD3+CD4+, NK cells and the CD4+/CD8+ value to increase significantly (P < 0.05) when analyzed by flow cytometry, which is better than the CrvpPS, sucrose-nano-Se, and even the positive drug levamisole.
Shen
WeiZai
W
Department of Anatomy, Medical College, Jinan University, Guangzhou, 510630, China. tshenwz@jnu.edu.cn
Wang
Hui
H
Guo
GuoQing
G
Tuo
JingJing
J
D000818:Animals; D046068:Caulerpa / Q000737:chemistry*; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D010316:Particle Size; D011134:Polysaccharides / Q000737:chemistry / Q000276:immunology* / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D012643:Selenium / Q000737:chemistry*; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology
D011134:Polysaccharides; D012643:Selenium