title: [Factor VIII activity among young Mexican patients with acute myocardial infarction].
abstract: BACKGROUND
  Atherothrombotic disease is the leading cause of death worldwide. Most casualties are due to acute myocardial infarction (AMI). Patients younger than 45 years account for 5-10% of AMI cases. These patients generally do not display typical atherothrombotic risk factors.
  
  
  METHODS
  Our cross-sectional study included adult patients under 45; men and women with AMI were included. A control group of healthy individuals matched for age, sex, and blood group was included to determine the role of several atherothrombotic risk factors on AMI. One hundred and sixty patients were included, the control group was comprised by 77 males (m) and 83 females (f)
  
  
  RESULTS
  Our results indicate that 25% of patients (23 m and 18 f) had increased FVIII compared with 8.8% of control subjects. Mean FVIII activity for patients and controls was 134 mg/dl (95%CI=114) vs. 118 mg/dl (95%CI=128-140), respectively (p=0.001). Prevalence of elevated FVIII was higher than the one found for hypertension or diabetes mellitus. HDL cholesterol was higher among patients than controls. Quantitative variables associated with AMI were high FVIII activity, blood monocyte count and HDL cholesterol.
  
  
  CONCLUSIONS
  Classical atherothrombotic risk factors do not fully explain AMI events in the young. High levels of FVIII activity is a moderate but common risk factor in young people suffering AMI.
authors: Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Hospital General Regional 1 Gabriel Mancera, IMSS, México, D.F., México, México. amajlufc@gmail.com
authors: Abraham
authors: A
authors: Majluf-Cruz
authors: Manuel
authors: M
authors: Moreno-Hernández
authors: Noemí
authors: N
authors: Martínez-Esquivel
authors: Adriana Aurelia
authors: AA
authors: Ruiz de Chávez-Ochoa
authors: Erika
authors: E
authors: Coria-Ramírez
authors: Rosario
authors: R
authors: Monroy-García
authors: Jorge
authors: J
authors: Vela-Ojeda
authors: Jaime
authors: J
authors: García-Chávez
authors: Marcelo
authors: M
authors: Basave-Rojas
authors: Miguel Angel
authors: MA
authors: Villasís-Keeverd
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005169:Factor VIII / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D012307:Risk Factors
chemical_list: D005169:Factor VIII