title: Solitary pleural plasmacytomas manifested as a massive pleural effusion without evidence of monoclonal gammopathy.
abstract: The majority of extramedullary plasmacytomas involve the upper respiratory tract but only a few are associated with serum monoclonal gammopathy. Most extramedullary plasmacytomas respond to local radiotherapy and have a better prognosis than multiple myeloma. Solitary plasmacytomas, involving the pleura, are very rare. This case report describes a patient with a solitary extramedullary plasmacytoma involving the pleura, and no evidence of serum, urine or pleural fluid paraproteins. Diagnosis was made by strongly positive immunohistochemical stains with CD38, CD138 and MUM-1 of the pleural tumour. The response to both radiotherapy and chemotherapy was poor and the patient died shortly after diagnosis.
authors: Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors: Po Hao
authors: PH
authors: Feng
authors: Chung-Chi
authors: CC
authors: Huang
authors: Chih-Wei
authors: CW
authors: Wang
authors: Yao-Kuang
authors: YK
authors: Wu
authors: Ying-Huang
authors: YH
authors: Tsai
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism; D000328:Adult; D006801:Humans; D050835:Interferon Regulatory Factors / Q000378:metabolism; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D010265:Paraproteinemias / Q000175:diagnosis* / Q000378:metabolism; D010266:Paraproteins / Q000378:metabolism; D010954:Plasmacytoma / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D016066:Pleural Effusion, Malignant / Q000175:diagnosis* / Q000378:metabolism; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D013902:Radiography, Thoracic; D053668:Syndecan-1 / Q000378:metabolism; D000099218:Interferon Regulatory Factor-4
chemical_list: D051997:ADP-ribosyl Cyclase 1; D050835:Interferon Regulatory Factors; D010266:Paraproteins; D053668:Syndecan-1; D000099218:Interferon Regulatory Factor-4