Developmental timing: let-7 function conserved through evolution.
Expression of the heterochronic microRNA let-7 is tightly correlated with the onset of adult development in many animals, suggesting that it functions as an evolutionarily conserved developmental timer. This hypothesis has now been confirmed by studies in Drosophila.
Tennessen
Jason M
JM
Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112-5330, USA.
Thummel
Carl S
CS
D000818:Animals; D001683:Biological Clocks; D005075:Biological Evolution; D004330:Drosophila; D018507:Gene Expression Regulation, Developmental; D008675:Metamorphosis, Biological; D035683:MicroRNAs / Q000378:metabolism*
C531976:Let-7 microRNA, Drosophila; D035683:MicroRNAs