SNAP-25 genotype influences NAA/Cho in left hippocampus.
The SNAP-25 gene is an integral part of the vesicle docking and fusion machinery that controls neurotransmitter release. Several post mortem studies revealed a reduction of SNAP-25 protein in the hippocampus of patients with schizophrenia and bipolar disorder (BD). Thirty-eight patients with schizophrenia, BD or obsessive-compulsive disorder and 17 healthy controls participated in the study. Proton magnetic resonance spectroscopy in left hippocampus was performed in each individual. Three single nucleotide polymorphisms (SNP) of the SNAP-25 gene were genotyped. Individuals with the homozygous CC genotype of the DdeI SNP presented a significantly higher ratio of N-acetyl-aspartate (NAA)/choline-containing compounds (Cho) in the left hippocampus compared to the group of individuals with the homozygous TT genotype. The SNAP-25 genotype may modulate synaptic plasticity and neurogenesis in the left hippocampus, and altered NAA/Cho ratio may be an indicator for this genetic modulation of neuronal function in the hippocampus.
Scherk
Harald
H
Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, von-Siebold-Str. 5, 37075, Göttingen, Germany. hscherk@uni-goettingen.de
Backens
Martin
M
Zill
Peter
P
Schneider-Axmann
Thomas
T
Wobrock
Thomas
T
Usher
Juliana
J
Reith
Wolfgang
W
Falkai
Peter
P
Möller
Hans-Jürgen
HJ
Bondy
Brigitta
B
Gruber
Oliver
O
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001714:Bipolar Disorder / Q000378:metabolism; D002794:Choline / Q000378:metabolism*; D004247:DNA / Q000235:genetics; D005260:Female; D005838:Genotype; D006624:Hippocampus / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012559:Schizophrenia / Q000378:metabolism; D050825:Synaptosomal-Associated Protein 25 / Q000235:genetics*
C494208:SNAP25 protein, human; D050825:Synaptosomal-Associated Protein 25; D001224:Aspartic Acid; D004247:DNA; C000179:N-acetylaspartate; D002794:Choline