title: Plasma leptin levels in pigs with different leptin and leptin receptor genotypes.
abstract: A C3469T mutation at exon 3 of the pig leptin (Lep) gene has been genotyped in diverse pig breeds yielding controversial results with regard to its association with growth, fatness and carcass traits. A similar situation has been reported for a HpaII restriction fragment length polymorphism (RFLP) in the pig leptin receptor (Lepr) gene, where associations were found depending on the statistical model employed. The main objective of our work was to investigate if leptin plasma concentrations differ in pigs with different C3469T and Lepr HpaII RFLP genotypes. With this aim, we have measured plasma leptin levels at 160 days in 68 Landrace pigs with different Lep C3469T and Lepr HpaII RFLP genotypes. Neither Lep (TT: 11.68 ng/ml, TC: 10.71 ng/ml) nor Lepr (AA: 12.6 ng/ml, AB: 10.93 ng/ml, BB: 11.74 ng/ml) genotypes influenced significantly plasma Lep concentration. Moreover, we did not find any association between Lep and Lepr genotypes and phenotypic variation at growth and fatness traits in a commercial population of 320 Landrace pigs.
authors: Departament de Ciència Animal i dels Aliments, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Spain. Marcel.Amills@uab.es
authors: M
authors: M
authors: Amills
authors: D
authors: D
authors: Villalba
authors: M
authors: M
authors: Tor
authors: A
authors: A
authors: Mercadé
authors: D
authors: D
authors: Gallardo
authors: B
authors: B
authors: Cabrera
authors: N
authors: N
authors: Jiménez
authors: J L
authors: JL
authors: Noguera
authors: A
authors: A
authors: Sànchez
authors: J
authors: J
authors: Estany
mesh_terms: D000818:Animals; D050218:Body Fat Distribution; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D020738:Leptin / Q000097:blood* / Q000235:genetics; D008297:Male; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D054411:Receptors, Leptin / Q000235:genetics*; D013552:Swine / Q000097:blood* / Q000235:genetics / Q000254:growth & development
chemical_list: D020738:Leptin; D054411:Receptors, Leptin