Context-dependent regulation of Groucho/TLE-mediated repression.
Groucho/TLE proteins are global corepressors that are recruited to target promoters by different families of DNA-binding repressors. As these corepressors are widely expressed, the long-standing view had been that Groucho/TLE-mediated repression is regulated solely by the spatial and temporal distribution of partner repressors. It has recently emerged, however, that Groucho/TLE repressor activity is itself regulated, in a signal induced, context-dependent manner. Here we review the essential roles played by Groucho/TLE factors in different cell-signalling processes that illustrate different modes for regulating Groucho/TLE-mediated repression: (i) via the expression of partner repressors; (ii) by competition with coactivators and (iii) through post-translational modifications of Groucho/TLE. We also discuss how the intrinsic properties of repressors can result in differential responses to Groucho/TLE regulation.
Cinnamon
Einat
E
Department of Biochemistry, Faculty of Medicine, The Hebrew University, PO Box 12272, Jerusalem 91120, Israel. ecinnam@nimr.mrc.ac.uk
Paroush
Ze'ev
Z
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000502:physiology*; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism / Q000502:physiology; D008957:Models, Genetic; D010766:Phosphorylation; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
D051792:Basic Helix-Loop-Helix Proteins; D020928:Mitogen-Activated Protein Kinases; D012097:Repressor Proteins; C091023:gro protein, Drosophila