title: Diagnosis of tuberculous lymphadenitis in Ethiopia: correlation with culture, histology and HIV status.
abstract: METHODS
  Butajira, Southern Ethiopia.
  
  
  OBJECTIVE
  To compare the diagnostic capacity of the clinical criteria for tuberculous lymphadenitis (TBLN) with histological and/or culture results and to assess the association of human immunodeficiency virus (HIV) with tuberculosis (TB) lymphadenitis.
  
  
  METHODS
  Patients (n=171) were included in the study from October 2005 until July 2006 at Butajira Hospital. Laboratory tests were performed to confirm TBLN. HIV status was identified in TBLN patients and retrospectively in 1608 healthy individuals.
  
  
  RESULTS
  A total of 136/161 (84.5%) patients were diagnosed with TBLN by histology. TBLN was culture-confirmed in 107/156 (68.6%) patients. The sensitivity, specificity, positive and negative predictive values of histology were respectively 92.5%, 49%, 79.8% and 75% when compared to culture as gold standard. Patients positive for TBLN by cytology and Ziehl-Neelsen (ZN) were also positive by histology and culture. Among the 143 confirmed TBLN patients, nine (6.3%) were HIV-positive. Of the 1608 healthy individuals, 77 (4.8%) were HIV-positive. Younger age (P=0.0001), female sex (P=0.016), not being married (P=0.0001) and illiteracy (P=0.016) showed a strong association with HIV in healthy individuals.
  
  
  CONCLUSIONS
  Clinical criteria alone over-diagnosed TBLN by 15.4% compared to histological and/or bacteriological results. The HIV prevalence in TBLN patients and healthy individuals was the same.
authors: Armauer Hansen Research Institute, Addis Ababa, Ethiopia. beyene88@yahoo.com
authors: D
authors: D
authors: Beyene
authors: S
authors: S
authors: Ashenafi
authors: L
authors: L
authors: Yamuah
authors: A
authors: A
authors: Aseffa
authors: H
authors: H
authors: Wiker
authors: H
authors: H
authors: Engers
authors: P
authors: P
authors: Klatser
authors: L
authors: L
authors: Sviland
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D003470:Culture Media; D005002:Ethiopia / Q000453:epidemiology; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D006679:HIV Seropositivity / Q000150:complications*; D015528:HIV Seroprevalence; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D012424:Rural Population; D012680:Sensitivity and Specificity; D014388:Tuberculosis, Lymph Node / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000821:virology
chemical_list: D003470:Culture Media