A tale of too many centrosomes.
Having the correct number of centrosomes is crucial for proper chromosome segregation during cell division and for the prevention of aneuploidy, a hallmark of many cancer cells. Several recent studies (Basto et al., 2008; Kwon et al., 2008; Yang et al., 2008) reveal the importance of mechanisms that protect against the consequences of harboring too many centrosomes.
Acilan
Ceyda
C
BioT Incorporated, Istanbul Technical University, Istanbul 34390, Turkey.
Saunders
William S
WS
D000818:Animals; D018385:Centrosome / Q000378:metabolism*; D006801:Humans; D008938:Mitosis; D009369:Neoplasms / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism