[Role of non-haem iron in protecting effect of ecdysterone on development of streptozocin-induced hyperglycaemia in rats].
Chronic hyperglycaemia (60 days) which developed after streptozotocine (STZ) administration (5 mg/100 g) in rats was accompanied with development of severe endothelial dysfunction as well as with disturbed non-haem iron metabolism. It was established by EPR spectroscopy method that STZ administration reduced transferrin levels in the blood as well as pools of iron associated with blood transferrin and with ferritin in the heart and aorta of rats with hyperglycaemia. Chronic ecdysterone administration (100 ng/100 g, 60 days) protects hyperglycaemia development by preventing of non-haem iron metabolism disturbance. These data suppose participation of non-haem iron in mechanisms of ecdysterone protection of streptozotocine-induced hyperglycaemia and ischemia.
Korkach
Iu P
IuP
Dudchenko
N O
NO
Kotsiuruba
A V
AV
Prysiazhna
O D
OD
Sahach
V F
VF
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004441:Ecdysterone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004578:Electron Spin Resonance Spectroscopy; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D006943:Hyperglycemia / Q000097:blood / Q000378:metabolism / Q000517:prevention & control*; D007501:Iron / Q000097:blood / Q000378:metabolism*; D008297:Male; D019159:Nonheme Iron Proteins / Q000378:metabolism*; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011921:Rats, Inbred WKY; D013311:Streptozocin; D014168:Transferrin / Q000378:metabolism
D001786:Blood Glucose; D019159:Nonheme Iron Proteins; D020011:Protective Agents; D014168:Transferrin; D004441:Ecdysterone; D013311:Streptozocin; D007501:Iron