Compliance with gluten-free diet in children with coeliac disease.
Coeliac disease (CD) is a lifelong disorder with gluten-induced manifestations in different organs. Gluten-free diet (GFD) is required to achieve remission and prevent complications; however, study reports on GFD growth effect are not consistent.



Compliance with GFD was estimated according to current body mass and height; presence of anaemia and other signs and symptoms; and attitude toward GFD.



Seventy-one patients with CD (mean age = 12 years; mean age after CD diagnosis = 9 years) were examined and their blood sampled for determination of endomysial antibodies (EMA), haemoglobin, and red blood cell count. Questionnaire analysis revealed 42 (59.1%; 4 EMA positive) patients to be on strict GFD, 19 (26.8%; 5 EMA positive) were taking small amounts of gluten, and 10 (14.1%; all EMA positive) were not on a diet at all. The patients on strict GFD had greatest body height, yet the difference was not significant. These patients also had a higher mean body mass (P = 0.05) and significantly higher mean haemoglobin and mean cell haemoglobin levels (P = 0.05 and P < 0.05, respectively). Apart from chronic fatigue in patients on partial diet (P = 0.05), patient groups did not differ significantly in the frequency of symptoms. Anaemia and delayed puberty were recorded only in noncompliers (P < 0.01 and P < 0.05, respectively). Noncompliers often found the specific diet to pose a major life burden (P < 0.01) and did not visit a gastroenterologist on a regular basis (P < 0.01).



Almost half of the coeliac patients were likely to abandon GFD without experiencing major symptoms, thus increasing the risk for developing complications later in life. An active attitude is required in the follow-up of patients with CD.
Jadresin
Oleg
O
Department of Paediatric Gastroenterology and Nutrition, Zagreb University Children's Hospital, Klaiceva 16, 10000 Zagreb, Croatia. oleg.jadresin@zg.t-com.hr
Misak
Zrinjka
Z
Kolacek
Sanja
S
Sonicki
Zdenko
Z
Zizić
Vesna
V
D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000453:epidemiology / Q000209:etiology; D001294:Attitude to Health; D001323:Autoantibodies / Q000097:blood; D002446:Celiac Disease / Q000097:blood / Q000150:complications / Q000178:diet therapy* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D055050:Diet, Gluten-Free / Q000523:psychology; D004906:Erythrocyte Count; D005260:Female; D005983:Glutens / Q000008:administration & dosage* / Q000009:adverse effects*; D006128:Growth / Q000502:physiology*; D006130:Growth Disorders / Q000453:epidemiology / Q000209:etiology; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D010349:Patient Compliance; D011628:Puberty, Delayed / Q000453:epidemiology / Q000209:etiology; D015430:Weight Gain; D055815:Young Adult
D001323:Autoantibodies; D006454:Hemoglobins; D005983:Glutens