title: Quorum sensing in staphylococci.
abstract: The staphylococcal agr locus encodes a quorum sensing (QS) system that controls the expression of virulence and other accessory genes by a classical two-component signaling module. Like QS modalities in other Gram-positive bacteria, agr encodes an autoactivating peptide (AIP) that is the inducing ligand for AgrC, the agr signal receptor. Unlike other such systems, agr variants have arisen that show strong cross-inhibition in heterologous combinations, with important evolutionary implications. Also unlike other systems, the effector of global gene regulation in the agr system is a major regulatory RNA, RNAIII. In this review, we describe the functions of the agr system's elements, show how they interact to bring about the regulatory response, and discuss the role of QS in staphylococcal pathobiology. We conclude with the suggestion that agr autoactivation, unlike classical enzyme induction, can occur under suboptimal conditions and can distinguish self from non-self by inducing an exclusive and coordinated population wide response.
authors: Kimmel Center for Biology and Medicine, New York University Medical Center, New York, New York 10016, USA. novick@saturn.med.nyu.edu
authors: Richard P
authors: RP
authors: Novick
authors: Edward
authors: E
authors: Geisinger
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics; D019143:Evolution, Molecular; D005798:Genes, Bacterial; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009154:Mutation; D009690:Nucleic Acid Conformation; D010456:Peptides, Cyclic; D017434:Protein Structure, Tertiary; D053038:Quorum Sensing / Q000235:genetics* / Q000502:physiology*; D012329:RNA, Bacterial / Q000737:chemistry / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013210:Staphylococcus / Q000235:genetics* / Q000502:physiology*
chemical_list: C414532:AgrD protein, Staphylococcus; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D010456:Peptides, Cyclic; D012329:RNA, Bacterial