Robust predictive control strategy applied for propofol dosing using BIS as a controlled variable during anesthesia.
This paper presents the application of predictive control to drug dosing during anesthesia in patients undergoing surgery. The performance of a generic predictive control strategy in drug dosing control, with a previously reported anesthesia-specific control algorithm, has been evaluated. The robustness properties of the predictive controller are evaluated with respect to inter- and intrapatient variability. A single-input (propofol) single-output (bispectral index, BIS) model of the patient has been assumed for prediction as well as for simulation. A set of 12 patient models were studied and interpatient variability and disturbances are used to assess robustness of the controller. Furthermore, the controller guarantees the stability in a desired range. The applicability of the predictive controller in a real-life environment via simulation studies has been assessed.
Ionescu
Clara M
CM
Department of Electrical Energy, Systems and Automation, Ghent University, B9000 Ghent, Belgium. clara@autoctrl.UGent.be
De Keyser
Robin
R
Torrico
Bismark Claure
BC
De Smet
Tom
T
Struys
Michel M R F
MM
Normey-Rico
Julio E
JE
D000465:Algorithms; D000758:Anesthesia / Q000379:methods*; D000777:Anesthetics / Q000008:administration & dosage*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography / Q000187:drug effects*; D005246:Feedback / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D015742:Propofol / Q000008:administration & dosage*
D000777:Anesthetics; D018686:Anesthetics, Intravenous; D015742:Propofol