title: Rtreemix: an R package for estimating evolutionary pathways and genetic progression scores.
abstract: In genetics, many evolutionary pathways can be modeled by the ordered accumulation of permanent changes. Mixture models of mutagenetic trees have been used to describe disease progression in cancer and in HIV. In cancer, progression is modeled by the accumulation of chromosomal gains and losses in tumor cells; in HIV, the accumulation of drug resistance-associated mutations in the viral genome is known to be associated with disease progression. From such evolutionary models, genetic progression scores can be derived that assign measures for the disease state to single patients. Rtreemix is an R package for estimating mixture models of evolutionary pathways from observed cross-sectional data and for estimating associated genetic progression scores. The package also provides extended functionality for estimating confidence intervals for estimated model parameters and for evaluating the stability of the estimated evolutionary mixture models.
authors: Max Planck Institute for Informatics, Saarbrücken, Germany. jasmina@mpi-inf.mpg.de
authors: Jasmina
authors: J
authors: Bogojeska
authors: Adrian
authors: A
authors: Alexa
authors: André
authors: A
authors: Altmann
authors: Thomas
authors: T
authors: Lengauer
authors: Jörg
authors: J
authors: Rahnenführer
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D018450:Disease Progression; D024882:Drug Resistance, Viral / Q000235:genetics; D019143:Evolution, Molecular; D006678:HIV / Q000187:drug effects / Q000235:genetics*; D015658:HIV Infections / Q000821:virology*; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D012984:Software