Pretreatment of pigments to prepare liquids for enteric coating.
Film coating fluids commonly contain different pigments. The objective of this work was a study of the distribution of these particles in the coating film. Different pretreatment forms (pigment suspension, pigment paste and untreated pigments) were applied. They were incorporated into a Eudragit L 30 D-55 dispersion. The surface roughness and the mechanical properties of the free films indicated, that the most homogeneous film was obtained with the pigment paste. The homogeneity of the film was investigated by mechanical testing. The protective effect of the coating did not vary with the application of pigments in different forms, but the appearance of the coated tablets underwent a considerable change.
Bölcskei
E
E
Department of Pharmaceutical Technology, University of Szeged, Hungary.
Bajdik
J
J
Müller
J
J
Knop
K
K
Kleinebudde
P
P
Pintye-Hódi
K
K
D004396:Coloring Agents / Q000737:chemistry*; D006245:Hardness Tests; D007202:Indicators and Reagents; D008689:Methacrylates; D011108:Polymers; D013499:Surface Properties; D013535:Suspensions; D013608:Tablets, Enteric-Coated / Q000737:chemistry*
D004396:Coloring Agents; C477852:Eudragit L 30 D-55; D007202:Indicators and Reagents; D008689:Methacrylates; D011108:Polymers; D013535:Suspensions; D013608:Tablets, Enteric-Coated