title: PNA/DNA interstrand cross-links from a modified PNA base upon photolysis or oxidative conditions.
abstract: PNA/DNA interstrand cross-links (ICLs) were observed when peptide nucleic acids (PNAs) containing modified thymine derivatives were hybridized with the complementary or one-base mismatched DNA upon photolysis or treatments of oxidative agent. PNA/DNA ICL formation provides a useful method for biological applications such as antisense technologies or PNA chips.
authors: Department of Chemistry, College of Natural Science, Kongju National University, 182 Shinkwan-dong, Kongju, Chungnam 314-701, Republic of Korea.
authors: Yongtae
authors: Y
authors: Kim
authors: In Seok
authors: IS
authors: Hong
mesh_terms: D003432:Cross-Linking Reagents; D004247:DNA / Q000378:metabolism*; D016373:DNA, Antisense / Q000032:analysis; D015394:Molecular Structure; D010084:Oxidation-Reduction; D020135:Peptide Nucleic Acids / Q000378:metabolism*; D010782:Photolysis; D013941:Thymine / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D003432:Cross-Linking Reagents; D016373:DNA, Antisense; D020135:Peptide Nucleic Acids; D004247:DNA; D013941:Thymine