title: Catalytic asymmetric addition of alcohols to imines: enantioselective preparation of chiral N,O-aminals.
abstract: The enantioselective addition of alcohols to imine electrophiles has been shown to proceed in the presence of a catalytic amount of a chiral phosphoric acid catalyst. The reaction allows for the formation of the respective chiral N,O-aminals in excellent yield and enantioselectivity. A total of 11 different alcohols and 11 different imines were successfully used as a clear demonstration of the reaction generality.
authors: Department of Chemistry, University of South Florida, 4202 East Fowler Avenue CHE205A, Tampa, Florida 33620, USA.
authors: Guilong
authors: G
authors: Li
authors: Frank R
authors: FR
authors: Fronczek
authors: Jon C
authors: JC
authors: Antilla