title: CT colonography: same-day tagging regimen with iodixanol and reduced cathartic preparation.
abstract: The purpose of the study was to test the tagging performance and patient's acceptance of a reduced cathartic preparation, based on iodixanol and PEG, administered to patients 3 h before the exam. One hundred and thirty-two asymptomatic patients were enrolled. As colonic cleansing we used PEG macrogol 3350. For fluid tagging iodixanol was orally administered 3 h before the exam, in a total dose of 50 mL mixed with 34.8 g of PEG in 750 mL of water. Image's review showed 446 segments (56.4%) clean of feces and 346 segments (43.6%) with feces. Untagged fluid was observed in 74/706 (10.5%) segments; inhomogeneous tagging in 129/706 (16%); the average density of fluid was 1054.74 UH in the cecum-ascending colon and 905.14 UH in the descending-sigmoid colon; the average difference of density between right and left colonic segments was 149 UH, and it was statistically significant (P = 0.016). No side effects related to the consumption of Movicol were reported. Very few side effects related to the tagging solution were reported: mild nausea in 7 (0.05%) patients, mild diarrhea in 10 (0.07%). An average rank of 9 points (SD +/- 1) on a 10-point scale (10 = no discomfort, 0 = severe discomfort) resulted from the self-administered questionnaire, showing an excellent acceptance of the preparation. Same day fluid tagging with iodixanol provides an optimal fluid tagging, it is completely tolerated by the patient, and it can be performed under medical control.
authors: University of Pisa, Italy. neri@med.unipi.it
authors: Emanuele
authors: E
authors: Neri
authors: Francesca
authors: F
authors: Turini
authors: Francesca
authors: F
authors: Cerri
authors: Paola
authors: P
authors: Vagli
authors: Carlo
authors: C
authors: Bartolozzi
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002400:Cathartics / Q000008:administration & dosage*; D003106:Colon / Q000000981:diagnostic imaging*; D023881:Colonography, Computed Tomographic; D006801:Humans; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D014283:Triiodobenzoic Acids / Q000008:administration & dosage
chemical_list: D002400:Cathartics; D014283:Triiodobenzoic Acids; D011092:Polyethylene Glycols; C044834:iodixanol