title: Injecting skin fibroblasts into muscles to express human clotting factor IX cDNA.
abstract: Primary rabbit skin fibroblasts (RSF) containing lacZ reporter gene or human clotting factor IX (hFIX) cDNA could long-termly exist and be expressed after being implanted in rabbit muscles. Among them, the beta-glactosidase expression lasted at least 3 months, and hFIX expression lasted 1 month. These results will be helpful to organically combine the advantages of both skin fibroblasts and muscle, and provide a new way for somatic gene therapy of hemophilia B and other genetic diseases.
authors: Institute of Genetics, Fudan University, 200433, Shanghai, China.
authors: H
authors: H
authors: Wang
authors: X
authors: X
authors: Yang
authors: Y
authors: Y
authors: Xing
authors: D
authors: D
authors: Lu
authors: X
authors: X
authors: Qiu
authors: J
authors: J
authors: Xue