Successful prevention of multidrug resistant HIV mother-to-child transmission with enfuvirtide use in late pregnancy.
The availability of antiretroviral therapy has dramatically reduced the risk of HIV mother-to-child transmission (MTCT). However, mothers infected with multidrug resistant HIV (MDR-HIV) are at increased risk of MTCT. We report the case of a pregnant patient infected with MDR-HIV in whom MTCT was avoided with enfuvirtide use in late pregnancy and elective caesarean section.
Madeddu
Giordano
G
Department of Infectious Diseases, University of Sassari, Via De Nicola 1, Sassari, Italy. giordano.madeddu@uniss.it
Calia
Giovanna Maria
GM
Campus
Maria Licinia
ML
Lovigu
Carla
C
Mannazzu
Marco
M
Olmeo
Paolina
P
Mela
Maria Graziella
MG
Mura
Maria Stella
MS
D000328:Adult; D018791:CD4 Lymphocyte Count; D002585:Cesarean Section; D024921:Drug Resistance, Multiple, Viral; D000077560:Enfuvirtide; D005260:Female; D015700:HIV Envelope Protein gp41 / Q000627:therapeutic use*; D023581:HIV Fusion Inhibitors / Q000627:therapeutic use*; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D010446:Peptide Fragments / Q000627:therapeutic use*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D016896:Treatment Outcome
D015700:HIV Envelope Protein gp41; D023581:HIV Fusion Inhibitors; D010446:Peptide Fragments; D000077560:Enfuvirtide