Efficacy of single-dose liposomal amphotericin B or micafungin prophylaxis in a neutropenic murine model of invasive pulmonary aspergillosis.
In a neutropenic murine model of invasive pulmonary aspergillosis, prophylaxis with single doses of liposomal amphotericin B or micafungin at >or=5 mg/kg of body weight improved animal survival and suppressed the lung fungal burden for up to 7 days after infection, demonstrating the potential utility of infrequent dosing with these antifungals.
Lewis
Russell E
RE
University of Houston College of Pharmacy, Texas Medical Center Campus, Houston, Texas 77030, USA. rlewis@uh.edu
Albert
Nathaniel D
ND
Kontoyiannis
Dimitrios P
DP
D000666:Amphotericin B / Q000008:administration & dosage*; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000302:isolation & purification; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D054714:Echinocandins / Q000008:administration & dosage*; D005260:Female; D055744:Invasive Pulmonary Aspergillosis / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control*; D055666:Lipopeptides / Q000008:administration & dosage*; D008081:Liposomes; D000077551:Micafungin; D051379:Mice; D008807:Mice, Inbred BALB C; D009503:Neutropenia / Q000150:complications / Q000188:drug therapy
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D008081:Liposomes; D000666:Amphotericin B; D000077551:Micafungin