Antiviral, antibacterial and vitamin C-synergized radical-scavenging activity of Sasa senanensis Rehder extract.
Sasa senanensis Rehder extract (SE) showed slightly higher cytotoxicity against human squamous cell carcinoma cell lines and human glioblastoma cell lines, as compared with human oral normal cells (gingival fibroblast, pulp cell, periodontal ligament fibroblast), and was more cytotoxic to human myelogenous and T-cell leukemia cell lines. SE showed a bacteriostatic effect on Fusobacterium nucleatum and Prevotella intermedia, but almost completely eliminated hydrogen sulfide (H2S) and methyl mercaptan (CH3SH) produced by these bacteria. SE protected human T-cell leukemia MT-4 cells from the cytopathic effect of human immunodeficiency virus (HIV) infection, and its anti-HIV activity was much higher than that of tannins and flavonoids, comparable with that of natural and synthetic lignins. SE also protected the MDCK cells from the cytopathic effect of influenza virus infection. SE synergistically enhanced the superoxide anion and hydroxyl radical-scavenging activity of vitamin C. The present study suggests the functionality of SE as a complementary alternative medicine.
Sakagami
Hiroshi
H
Meikai Pharmaco-Medical Laboratory, Meikai University School of Dentistry, Sakado, Saitama, Japan. sakagami@dent.meikai.ac.jp
Amano
Shigeru
S
Kikuchi
Hirotaka
H
Nakamura
Yukio
Y
Kuroshita
Reina
R
Watanabe
Shigeru
S
Satoh
Kazue
K
Hasegawa
Hideo
H
Nomura
Akiko
A
Kanamoto
Taisei
T
Terakubo
Shigemi
S
Nakashima
Hideki
H
Taniguchi
Sumiko
S
Oizumi
Takaaki
T
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019380:Anti-HIV Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism* / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D004285:Dogs; D004357:Drug Synergism; D005347:Fibroblasts / Q000378:metabolism; D016166:Free Radical Scavengers / Q000494:pharmacology; D015658:HIV Infections / Q000517:prevention & control; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D031787:Sasa / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D000998:Antiviral Agents; D016166:Free Radical Scavengers; D010936:Plant Extracts; D001205:Ascorbic Acid