Familial unilateral Brown syndrome.
We present a two-generation family with Brown syndrome. The proband was a six and a half-year-old female who presented with a history of failure of dextro-elevation of her left eye. A full ophthalmic evaluation was consistent with a left Brown syndrome. Family history revealed that her mother was operated on as a child for left Brown syndrome and examination of her four and a half-year-old sibling showed similar affection in the left eye. Autosomal dominant inheritance has been postulated in this condition. To our knowledge this is the first report of three members of a two-generation family with left-sided Brown syndrome. Genetic counseling of Brown syndrome cases is advised; nevertheless, identification of the responsible gene should shed more light on its genetics.
Kenawy
Nihal
N
St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, L7 8XP, United Kingdom.
Pilz
Daniela T
DT
Watts
Patrick
P
D000328:Adult; D002648:Child; D005133:Eye Movements / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D008297:Male; D009679:Nuclear Family; D015835:Ocular Motility Disorders / Q000235:genetics* / Q000503:physiopathology; D010375:Pedigree; D010641:Phenotype; D015348:Vision, Binocular