[Molecular characteristics of testosterone binding globulin and analysis of their regulation].
Molecular characteristics of testosterone binding globulin (TeBG) were investigated in microaliquots of human serum samples using 3H-5-alpha-dihydrotestosterone radioligand assays. Under experimental conditions used TeBG demonstrated high conformational plasticity and ability to adopt three conformational states (olygo-, di-, and monomer) with different functional activities. Using alipidspolyene complex from basidiomycete Laetiporus sulphureus we demonstrate a novel effective pharmacological correction of the TeBG characteristics.
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D000293:Adolescent; D000818:Animals; D002648:Child; D002850:Chromatography, Gel; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D008055:Lipids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020072:Polyporales / Q000737:chemistry; D011869:Radioligand Assay; D051381:Rats; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D008055:Lipids; D011090:Polyenes; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone