title: Regioselective synthesis and antimicrobial screening of novel ketocarbazolodispiropyrrolidine derivatives.
abstract: A series of novel dispiropyrrolidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from sarcosin and di/tri ketone with the dipolarophile (E)-2-arylidine-1-keto-carbazoles. The cycloadducts ketocarbazalo spiro N-methyl pyrrolidines showed the most interesting antimicrobial activity at lower concentration.
authors: Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, Tamil Nadu, India.
authors: Govindasami
authors: G
authors: Periyasami
authors: Raghavachary
authors: R
authors: Raghunathan
authors: Gangadharan
authors: G
authors: Surendiran
authors: Narayanasamy
authors: N
authors: Mathivanan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D011514:Proteus vulgaris / Q000187:drug effects; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012485:Salmonella typhi / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D011759:Pyrrolidines