Apolipoprotein E-epsilon 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV.
Apolipoprotein E (APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes. We investigated the potential association between the APOE-epsilon 4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-epsilon 4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95% CI 2.4 to 28.5). To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-epsilon 4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV.
Jayasuriya
A N
AN
Department of Genito-Urinary Medicine, Hawthorn House, Heartlands Hospital, Bordsley Green East, Birmingham B9 5SS, UK. ashini@doctors.net.uk
Itzhaki
R F
RF
Wozniak
M A
MA
Patel
R
R
Smit
E J
EJ
Noone
R
R
Gilleran
G
G
Taylor
S
S
White
D J
DJ
D017088:AIDS-Related Opportunistic Infections / Q000150:complications*; D000483:Alleles; D053327:Apolipoprotein E4 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006558:Herpes Genitalis / Q000150:complications*; D018258:Herpesvirus 2, Human / Q000235:genetics*; D006801:Humans; D008297:Male
D053327:Apolipoprotein E4