Clinical pharmacokinetics of isolated pelvic perfusion.
The pharmacokinetic results of this study indicate that there is significant enhancement of pelvic drug levels with isolated pelvic perfusion, with the potential of increasing the therapeutic index and clinical efficacy. This system would seem to be ideal for evaluating fast-acting and highly toxic experimental drugs on human pelvic cancers having treatment protocols of limited clinical success. Pharmacokinetic modeling using empiric approximations for the kinetic rate constants is a convenient and novel way of fitting data using relatively simple mathematics and commercially available spreadsheets.
Belliveau
James F
JF
Division of Surgical Oncology, Roger Williams Medical Center, Boston University School of Medicine, 825 Chalkstone Avenue, Providence, RI 02908, USA.
Wanebo
Harold J
HJ
D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D006801:Humans; D008962:Models, Theoretical; D010386:Pelvic Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents