title: Occupational infection due to Brucella abortus S19 among workers involved in vaccine production in Argentina.
abstract: The pathological consequences of exposure to the vaccine strain Brucella abortus S19 were evaluated in 30 employees from vaccine-manufacturing plants. Active brucellosis was diagnosed in 21 subjects, of whom only five recalled an accidental exposure. Clinical manifestations were mild, and only one patient presented a complication. After antimicrobial therapy, initially symptomatic patients either experienced clinical remission or had mild persistent symptoms. This is the first study reporting infection by B. abortus S19 among workers from vaccine-manufacturing plants, which in many cases was acquired from unnoticed exposures. Measures to improve the safety of B. abortus S19 handling should be implemented.
authors: Hospital F. J. Muñiz, Buenos Aires.
authors: J C
authors: JC
authors: Wallach
authors: M C
authors: MC
authors: Ferrero
authors: M
authors: M
authors: Victoria Delpino
authors: C A
authors: CA
authors: Fossati
authors: P C
authors: PC
authors: Baldi
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D001118:Argentina / Q000453:epidemiology; D002004:Brucella Vaccine; D002003:Brucella abortus / Q000276:immunology* / Q000302:isolation & purification; D002006:Brucellosis / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D004345:Drug Industry / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D017056:Medical Laboratory Personnel; D008875:Middle Aged; D016273:Occupational Exposure
chemical_list: D000907:Antibodies, Bacterial; D002004:Brucella Vaccine