title: Malignant lesions in the ventral prostate of alloxan-induced diabetic rats.
abstract: The aim of this study was to evaluate the changes caused by chronic diabetes in the rat ventral prostate and to establish a correlation between diabetes and the development of prostatic lesions. Male rats received alloxan (42 mg/kg b.w.) to induce diabetes. Ninety days after diabetes diagnosis, animals were sacrificed and the ventral prostate was removed and prepared for general and immunohistochemical analyses. The total area showing different types of lesions was estimated. Diabetes led to a decrease in the body and prostatic weights, as well as in testosterone levels. The prostate morphology and stereology showed high variation in the diabetic group. Some animals had light changes; the great majority had an intense epithelial atrophy; and other rats showed premalignant and malignant lesions in the prostate. Such epithelial atrophy was, in some samples, combined with chronic inflammation, similar to proliferative inflammatory atrophy (PIA). The diabetic group also presented high incidence of prostatitis, adenocarcinoma and prostatic intra-epithelial neoplasia (PIN). Samples with adenocarcinoma had poorly differentiated acini with high levels of cellular proliferation and nuclear atypia. These lesions exhibited an invasive feature showing Bcl-2-positive cells and interruptions in the basement membrane. An association of PIA, PIN and adenocarcinoma was detected in one sample. Reduced androgen levels have a synergic effect to insulin dysfunction promoting negative effects in the rat prostate. Diabetic individuals had a high incidence of prostatitis, and this inflammation could stimulate the incidence of other forms of prostatic pathology.
authors: Department of Cell Biology, State University of Campinas, Unicamp, Campinas, Brazil.
authors: Daniele Lisboa
authors: DL
authors: Ribeiro
authors: Silvio Fernando Guideti
authors: SF
authors: Marques
authors: Sandra
authors: S
authors: Alberti
authors: César Tadeu
authors: CT
authors: Spadella
authors: Antônio José
authors: AJ
authors: Manzato
authors: Sebastião Roberto
authors: SR
authors: Taboga
authors: Nishtman
authors: N
authors: Dizeyi
authors: Per-Anders
authors: PA
authors: Abrahamsson
authors: Rejane Maira
authors: RM
authors: Góes
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000209:etiology* / Q000473:pathology; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications* / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D011467:Prostate / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000097:blood / Q000473:pathology; D019048:Prostatic Intraepithelial Neoplasia / Q000097:blood / Q000473:pathology; D011471:Prostatic Neoplasms / Q000097:blood / Q000209:etiology* / Q000473:pathology; D011472:Prostatitis / Q000097:blood / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D019063:Tenascin / Q000032:analysis; D013739:Testosterone / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D019253:Proto-Oncogene Proteins c-bcl-2; D019063:Tenascin; D013739:Testosterone