title: Spontaneous formation of bilayers and vesicles in mixtures of single-chain alkyl carboxylates: effect of pH and aging and cytotoxicity studies.
abstract: We report the observation of bilayer fragments, some of which close to form vesicles, over a large range of pH at room temperature from mixtures of single-chain biocompatible commercially available nontoxic alkyl carboxylic surfactants after neutralization with HCl. The pH at which the morphological transitions occur is varied only by changing the ratio between two surfactants: the alkyloligoethyleneoxide carboxylate and sodium laurate. The effect of aging of the mixed surfactant systems in the pH region desired for dermatologic application (4.5 < pH < 7) is also studied. Finally, we show results of cytotoxicity studies on the surfactant mixtures.
authors: Institute of Physical and Theoretical Chemistry and Department of Pharmaceutical Biology, University of Regensburg, Regensburg, Germany,
authors: N
authors: N
authors: Vlachy
authors: C
authors: C
authors: Merle
authors: D
authors: D
authors: Touraud
authors: J
authors: J
authors: Schmidt
authors: Y
authors: Y
authors: Talmon
authors: J
authors: J
authors: Heilmann
authors: W
authors: W
authors: Kunz
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D020285:Cryoelectron Microscopy; D006367:HeLa Cells; D006801:Humans; D006851:Hydrochloric Acid / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007850:Lauric Acids / Q000737:chemistry; D008027:Light; D008051:Lipid Bilayers / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D044367:Phase Transition; D013501:Surface-Active Agents; D013778:Tetrazolium Salts / Q000737:chemistry / Q000494:pharmacology; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D002264:Carboxylic Acids; D007850:Lauric Acids; D008051:Lipid Bilayers; D013501:Surface-Active Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; C030358:lauric acid; C022616:thiazolyl blue; D006851:Hydrochloric Acid