title: Hepatocellular carcinoma with intracavitary cardiac involvement: a case report and review of the literature.
abstract: A 71-year-old man with hepatocellular carcinoma (HCC) presented with intracavitary cardiac involvement detected incidentally on surveillance computed tomography. Tumor with associated thrombus was found to extend from the liver through the inferior vena cava into the right atrium. This intracardiac mass prolapsed intermittently into the right ventricle, causing functional tricuspid stenosis. The mass was resected but recurred after 4 months, eventually causing refractory right-sided heart failure. This case illustrates how intracavitary cardiac involvement of HCC can develop insidiously and confer significant hemodynamic compromise. A review of the published research, including postmortem studies, demonstrates that the frequency of intracardiac mass lesions in HCC is not insignificant. In conclusion, early detection and diagnosis may have increasing importance in the advent of new therapies for treating advanced HCC.
authors: Harvard Medical School, Boston, Massachusetts, USA.
authors: Anthony D
authors: AD
authors: Sung
authors: Susan
authors: S
authors: Cheng
authors: Javid
authors: J
authors: Moslehi
authors: Eileen P
authors: EP
authors: Scully
authors: Jason M
authors: JM
authors: Prior
authors: Joseph
authors: J
authors: Loscalzo
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000175:diagnosis / Q000556:secondary*; D003937:Diagnosis, Differential; D006325:Heart Atria; D006338:Heart Neoplasms / Q000150:complications / Q000175:diagnosis / Q000556:secondary*; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed; D014682:Vena Cava, Inferior; D020246:Venous Thrombosis / Q000175:diagnosis / Q000209:etiology