c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.
The oncogene c-Jun has been found to be up-regulated in a variety of cancers including osteosarcoma. DNA enzymes (DNAzymes) are oligonucleotides capable of specific catalysis of target mRNA. A c-Jun DNAzyme inhibited the growth and metastasis of osteosarcoma in an orthotopic spontaneously metastasizing model of the disease. c-Jun down-regulation-mediated apoptosis in osteosarcoma cells involved caspase-1, caspase-2, and caspase-8, but not the Fas/FasL pathway. Clinically, knockdown of c-Jun with DNAzymes may proffer an improved treatment outcome for these tumors originating in bone.
Dass
Crispin R
CR
Department of Orthopaedics, St. Vincent's Hospital, Fitzroy, Melbourne, Victoria 3065, Australia. cris.dass@yahoo.com
Khachigian
Levon M
LM
Choong
Peter F M
PF
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001859:Bone Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D021881:DNA, Catalytic / Q000494:pharmacology; D004195:Disease Models, Animal; D018450:Disease Progression; D015536:Down-Regulation / Q000187:drug effects; D006801:Humans; D051379:Mice; D009362:Neoplasm Metastasis; D012516:Osteosarcoma / Q000473:pathology*; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*
D021881:DNA, Catalytic; C485475:Dz13 DNAzyme; D016755:Proto-Oncogene Proteins c-jun