Bioactive, luminescent and mesoporous europium-doped hydroxyapatite as a drug carrier.
Bioactive, luminescent and mesoporous europium-doped hydroxyapatite (Eu:HAp) was successfully prepared through a simple one-step route using cationic surfactant as template. The obtained multifunctional hydroxyapatite was performed as a drug delivery carrier to investigate the drug storage/release properties using ibuprofen (IBU) as a model drug. The structural, morphological, textural and optical properties were well characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectra (XPS), Fourier transform infrared spectroscopy (FT-IR), N(2) adsorption/desorption, and photoluminescence (PL) spectra, respectively. The results reveal that the multifunctional hydroxyapatites exhibit the typical ordered characteristics of the hexagonal mesostructure, and have rod-like morphology with the particle size of 20-40 nm in width and 100-200 nm in length. The drug storage/release test indicates that the luminescent HAp shows much similar drug loading amount and cumulative release rate to those of pure HAp. Interestingly, the IBU-loaded samples still show red luminescence of Eu(3+) ((5)D(0)-(7)F(1),(2)) under UV irradiation, and the emission intensities of Eu(3+) in the drug carrier system vary with the released amount of IBU, thus making the drug release be easily tracked and monitored by the change of the luminescence intensity.
Yang
Piaoping
P
College of Material Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, PR China.
Quan
Zewei
Z
Li
Chunxia
C
Kang
Xiaojiao
X
Lian
Hongzhou
H
Lin
Jun
J
D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism*; D017886:Durapatite / Q000737:chemistry* / Q000378:metabolism*; D005063:Europium / Q000737:chemistry*; D049449:Luminescence; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D016062:Porosity; D013057:Spectrum Analysis; D014961:X-Ray Diffraction
D004337:Drug Carriers; D005063:Europium; D017886:Durapatite