title: Myocardial lysis in a fetus induced by maternal paraphenylenediamine poisoning following an intentional ingestion to induce abortion.
abstract: The acute toxicity of paraphenylenediamine (PPD) has been associated with several histopathological changes. In humans, acute PPD poisoning is known to cause rhabdomyolisis and particularly myocardial lysis. However, its toxicity for the fetus has never been reported in the literature. We report a case of myocardial lysis in a fetus expelled by a 22-year-old mother after apparent ingestion of an unknown amount of PPD. The patient was admitted to our intensive care unit with acute onset of respiratory distress and rhabdomyolysis. The pelvic ultrasonography on admission showed a normally progressing pregnancy of 23-24 weeks. On day 9 post-ingestion, the patient spontaneously expelled a non-viable fetus. The fetal examination did not show any external or macroscopic abnormalities. However, the histopathological exam showed an important heart and lung congestion. There was also some interstitial edema and inflammation at the base of the lingua, in addition to a chorionic villus thrombosis and abruptio placentae. The histopathology of the myocardium showed lysis of the cardiac muscle. This observation suggests that the PPD was most likely responsible for the myocardial injury in the fetus.
authors: Emergency and Medical ICU, Ibn Sina University Hospital, CHU Ibn Sina, Rabat, Morocco. abidikhalid@invivo.edu
authors: K
authors: K
authors: Abidi
authors: B
authors: B
authors: Himdi
authors: N
authors: N
authors: Cherradi
authors: N
authors: N
authors: Lamalmi
authors: Z
authors: Z
authors: Alhamany
authors: Aa
authors: A
authors: Zeggwagh
authors: R
authors: R
authors: Abouqal
mesh_terms: D000024:Abortion, Illegal; D000284:Administration, Oral; D000328:Adult; D004396:Coloring Agents / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced* / Q000473:pathology; D005865:Gestational Age; D006321:Heart / Q000187:drug effects* / Q000196:embryology; D006801:Humans; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D009205:Myocarditis / Q000139:chemically induced* / Q000196:embryology / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D010655:Phenylenediamines / Q000009:adverse effects*; D011247:Pregnancy
chemical_list: D004396:Coloring Agents; D010655:Phenylenediamines; C029728:4-phenylenediamine