title: Risk factors for treatment failure in renal suppurative infections.
abstract: There are conflicting results of published studies about prognostic value of various factors in purulent renal infections. The purpose of this study was to identify and quantify potential risk factors for early and late treatment failure in such infections. A retrospective review of 75 renal suppurative infections, at three tertiary Serbian Clinics of Urology, was conducted. We considered numerous potential risk factors in a multivariate analysis. This series was comprised of 49 women and 26 men, with mean age of 56.7 years. There were 38 and 37 patients who experienced successful and unfavorable early treatment outcome, respectively. Overall mortality rate was 9.3%. Comorbidity [odds ratio (OR) = 1.6], complex suppurative pathological findings (OR = 3.6), presence of Pseudomonas spp. (OR = 6.7), multiple bacterial strains (OR = 2.7), and positive culture itself (OR = 3.6) were the predictors of poor early prognosis. A urological intervention and presence of pyonephrosis significantly increased the chance for good initial outcome (OR = 0.32 and 0.37, respectively). In the late treatment failure analysis presence of comorbidities (OR = 5.8) and treatment complications (OR = 7.5) significantly increased chance for fatal outcome. Patients' baseline health status and complexity of suppuration itself were the most important predictors of clinical outcomes. Surgical drainage dominated over antimicrobial therapy.
authors: Department of Urology, Clinic of Urology and Nephrology, Clinical Centre, Zmaj Jovina 30, Kragujevac 34 000, Serbia. midinac@eunet.yu
authors: Miroslav M
authors: MM
authors: Stojadinović
authors: Sava R
authors: SR
authors: Mićić
authors: Dragan R
authors: DR
authors: Milovanović
authors: Slobodan M
authors: SM
authors: Janković
mesh_terms: D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use; D015331:Cohort Studies; D004322:Drainage; D005260:Female; D006304:Health Status; D006801:Humans; D007674:Kidney Diseases / Q000382:microbiology* / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D010349:Patient Compliance; D012189:Retrospective Studies; D012307:Risk Factors; D013492:Suppuration / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D017211:Treatment Failure; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents