title: A chemometric strategy for optimization of solid-phase microextraction: determination of bisphenol A and 4-nonylphenol with HPLC.
abstract: A sensitive method for the analysis of bisphenol A and 4-nonylphenol is developed by means of the optimization of solid-phase microextraction using Uniform Experimental Design methodology followed by high-performance liquid chromatographic analysis with fluorescence detection. The optimal extraction conditions are determined based on the relationship between parameters and the peak area. The curve calibration plots are linear (r2>or=0.9980) over the concentration range of 1.25-125 ng/mL for bisphenol A and 2.59-202.96 ng/mL for 4-nonylphenol, respectively. The detection limits, based on a signal-to-noise ratio of 3, are 0.097 ng/mL for bisphenol A and 0.27 ng/mL for 4-nonylphenol, respectively. The validity of the proposed method is demonstrated by the analysis of the investigated analytes in real water samples and sensitivity of the optimized method is verified by comparing results with those obtained by previous methods using the same commercial solid-phase microextraction fiber.
authors: College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou-730000, China.
authors: Xiaoyan
authors: X
authors: Liu
authors: Xiaoyun
authors: X
authors: Zhang
authors: Haixia
authors: H
authors: Zhang
authors: Mancang
authors: M
authors: Liu
mesh_terms: D001559:Benzhydryl Compounds; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D010636:Phenols / Q000032:analysis*; D052617:Solid Phase Microextraction / Q000379:methods*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; C041594:4-nonylphenol; C006780:bisphenol A; D000098826:Bisphenol A Compounds