Epidural haloperidol enhances epidural morphine analgesia: three case reports.
Epidural opioids provide significant postoperative analgesia; however, their use is often limited by side effects such as nausea and pruritus, or they require the addition of epidural local anesthetics with possible side effects of motor block and hypotension. Adjuncts to epidural opioid analgesia would benefit pain management. There is evidence that epidural butyrophenones may enhance opioid analgesics and reduce side effects. The authors present the first reported use of epidural haloperidol to enhance epidural morphine analgesia in three individuals. Pharmacodynamic interactions of haloperidol, which may explain its analgesic efficacy, are summarized.
Colclough
George
G
Department of Anesthesiology, University of Kentucky Hospital, Lexington, Kentucky, USA.
McLarney
John T
JT
Sloan
Paul A
PA
McCoun
K Todd
KT
Rose
Gregory L
GL
Grider
J S
JS
Steyn
P
P
D015360:Analgesia, Epidural; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019644:Arthroplasty, Replacement, Hip; D004357:Drug Synergism; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000601:surgery; D010147:Pain Measurement / Q000187:drug effects; D010149:Postoperative Pain / Q000188:drug therapy; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000601:surgery
D000701:Analgesics, Opioid; D014150:Antipsychotic Agents; D009020:Morphine; D006220:Haloperidol