Comparison of osteogenic potential between apatite-coated poly(lactide-co-glycolide)/hydroxyapatite particulates and Bio-Oss.
Previously, we developed a poly(lactide-co-glycolide)/nano-hydroxyapatite (PLGA/HA) composite that overcame the limitations of conventional ceramic bone substitutes. This was achieved by introducing a bone-like apatite layer on the composite to further enhance its osteogenic potential. In this study, we compared the osteogenic potential of the apatite-coated PLGA/HA particulates to that of Bio-Oss, a deproteinized bovine bone material. A mixture of fibrin gel and either apatite-coated PLGA/HA particulates or Bio-Oss was implanted into critical-size rat calvarial defects. As a control, fibrin gel was implanted alone into the defects. At eight weeks after treatment, histological examination showed new bone formation around the grafting materials, and bone formation was similar between the two groups. In the control group, bone was not regenerated and the defects were filled with fibrous tissues. This study showed that a synthetic bone graft material, apatite-coated PLGA/HA particulates, had a comparable bone regeneration potential to the bovine-derived bone graft material, Bio-Oss.
Kim
Sang-Soo
SS
Department of Bioengineering, Hanyang University, Seoul 133-791, Korea.
Kim
Byung-Soo
BS
D000818:Animals; D001391:Azo Compounds; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001847:Bone Diseases / Q000473:pathology / Q000601:surgery; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D004396:Coloring Agents; D004337:Drug Carriers; D017886:Durapatite / Q000627:therapeutic use*; D004801:Eosine Yellowish-(YS); D005337:Fibrin; D005782:Gels; D007091:Image Processing, Computer-Assisted; D019344:Lactic Acid / Q000627:therapeutic use*; D008297:Male; D008739:Methyl Green; D008855:Microscopy, Electron, Scanning; D008903:Minerals / Q000627:therapeutic use*; D010012:Osteogenesis / Q000502:physiology*; D011091:Polyesters / Q000627:therapeutic use*; D011100:Polyglycolic Acid / Q000627:therapeutic use*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats; D017207:Rats, Sprague-Dawley; D012886:Skull / Q000473:pathology / Q000601:surgery; D013997:Time Factors
D001391:Azo Compounds; C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D004396:Coloring Agents; D004337:Drug Carriers; D005782:Gels; D008903:Minerals; D011091:Polyesters; C499699:hydroxyapatite-polylactide; C017768:trichrome stain; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D008739:Methyl Green; D005337:Fibrin; D017886:Durapatite; D004801:Eosine Yellowish-(YS)