Pharmacokinetics and excretion of chlorogenic acid in beagle dogs.
In order to characterize the pharmacokinetics and excretion of chlorogenic acid (ChA) in beagle dogs, a gradient high performance liquid chromatographic method has been developed and validated for determining ChA concentration in dog serum, urine and feces. The pharmacokinetic profile of ChA in dog after an intravenous injection was best described by a two-compartment model. Terminal half-lifes were similar at dosages of 5, 20 and 50 mg/kg, ranging from 41-45 min, while AUC and Cmax values of ChA were dose proportional. There are no differences in Vd and CL at three doses of ChA, ranging from 133-252 mL/kg and from 4.4-6.3 mL/min/kg respectively. Excretion studies showed that more than 67% ChA was excreted into urine and less than 3% ChA was eliminated into feces.
Zhong
Shilong
S
Center for Clinical Pharmacology, University of Pittsburgh, USA.
Liu
Jing
J
Ren
Xia
X
Zhang
Jie
J
Zhou
Sha
S
Xu
Xiao-Ping
XP
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002138:Calibration; D002726:Chlorogenic Acid / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D005243:Feces / Q000737:chemistry; D005260:Female; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D011485:Protein Binding; D011786:Quality Control; D012015:Reference Standards; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet
D001798:Blood Proteins; D002726:Chlorogenic Acid