title: Myeloid sarcoma in the central nervous system: case report and review of the literature.
abstract: Myeloid sarcomas are rare manifestations of mainly myeloblastic leukemia. Their occurrence in the central nervous system is exceptional and current literature is limited to case studies. A case is added herewith and a review was performed to investigate clinical characteristics and treatment options of central nervous system myeloid sarcoma. A 61-year-old female with acute myeloblastic leukemia (FAB M5) and progressive left sided hemiparesis showed a right parieto-occipital epidural lesion mimicking meningioma. Partial resection was performed to reveal a myeloid sarcoma. Reviewing the literature we identified 44 cases with sufficient description of the diagnosis, treatment and follow up to one year. In these patients different treatment regimens were applied. However, when systemic chemotherapy or irradiation was included in the treatment regimen, patients showed the best 1-year survival proportion.
authors: Department of Neurology, Kaiser Franz Josef Spital, Vienna, Austria. walter.struhal@akh.linz.at
authors: Walter
authors: W
authors: Struhal
authors: Stefan
authors: S
authors: Oberndorfer
authors: Heinz
authors: H
authors: Lahrmann
authors: Elisabeth
authors: E
authors: Lindeck-Pozza
authors: Barbara
authors: B
authors: Hess
authors: Vera
authors: V
authors: Nussgruber
authors: Rainer
authors: R
authors: Pöhnl
authors: Thomas
authors: T
authors: Dobner
authors: Wolfgang
authors: W
authors: Grisold
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D009778:Occipital Lobe; D010296:Parietal Lobe; D023981:Sarcoma, Myeloid / Q000175:diagnosis*