title: Asthma arising in flavoring-exposed food production workers.
abstract: OBJECTIVE
  While working for a small family-owned popcorn popping company, all of the three non-smoking workers developed a respiratory disease. Because of the newly identified associations between the flavoring chemicals and bronchiolitis obliterans, the specifics of these cases and their exposures were investigated to add to the body of knowledge of flavoring-related lung disease.
  
  
  METHODS
  We obtained data on work processes as well as full-shift personal and area air samples for diacetyl, acetoin, 2-nonanone, acetaldehyde, and total volatile organic compounds. Air samples were collected on thermal desorption tubes for analysis by gas chromatography mass spectrometry. We also reviewed medical records and conducted interview with the workers.
  
  
  RESULTS
  Air samples representative of the exposures that exacerbated asthma symptoms in two workers contained many different aldehydes. The data from interview and medical records and the high resolution computed tomograms of the chest indicated the presence of occupational asthma in all the three workers and possible bronchiolitis obliterans in two of them. This case series emphasizes a need for exposure reduction and medical surveillance among workers exposed to flavoring chemicals, and provides evidence for an increased risk of occupational asthma, as well as bronchiolitis obliterans, in flavoring-exposed workers.
authors: Centers for Disease Control and Prevention (CDC) Field Studies Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
authors: Nancy
authors: N
authors: Sahakian
authors: Gregory
authors: G
authors: Kullman
authors: David
authors: D
authors: Lynch
authors: Kathleen
authors: K
authors: Kreiss
mesh_terms: D000395:Air Pollutants, Occupational / Q000506:poisoning*; D001249:Asthma / Q000139:chemically induced*; D001989:Bronchiolitis Obliterans / Q000139:chemically induced*; D005260:Female; D005421:Flavoring Agents / Q000506:poisoning*; D005525:Food-Processing Industry; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure
chemical_list: D000395:Air Pollutants, Occupational; D005421:Flavoring Agents