title: [Expression and clinical significance of E-cadherin and beta-catenin proteins in human laryngeal cancer].
abstract: OBJECTIVE
  To investigate the roles of E-cadherin and beta-catenin play in the carcinogenesis and progression of laryngeal carcinoma.
  
  
  METHODS
  Immunohistochemistry staining (PicTure two steps method) was used to detect E-cadherin and beta-catenin proteins expression in laryngeal carcinomas and normal epithelia around tumors.
  
  
  RESULTS
  In 60 laryngeal carcinomas, the abnormal expression rates of E-cadherin and beta-catenin were 55.00% and 66.67% respectively. The significant relationship was observed between abnormal E-cadherin and beta-catenin expression and differentiation, clinical stage and lymph node metastasis. There was a positive relationship between the expression of beta-catenin and E-cadherin in same sample.
  
  
  CONCLUSIONS
  The abnormal expression of E-cadherin and beta-catenin were closely related with differentiation, clinical stage, metastasis in laryngeal carcinoma.
authors: Department of Otorhinolaryngology, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China.
authors: Wei Feng
authors: WF
authors: Si
authors: Wenha
authors: W
authors: Sun
authors: Huamin
authors: H
authors: Liu
authors: Jie
authors: J
authors: Liu
authors: Yan
authors: Y
authors: Sun
authors: Zhijun
authors: Z
authors: Chen
mesh_terms: D000328:Adult; D000368:Aged; D015820:Cadherins / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D051176:beta Catenin / Q000378:metabolism*
chemical_list: C495270:CTNNB1 protein, human; D015820:Cadherins; D051176:beta Catenin