title: Adenoviral-mediated interleukin-18 expression in mesenchymal stem cells effectively suppresses the growth of glioma in rats.
abstract: Glioma is the most common primary intracranial malignant tumor. Despite advances in surgical techniques and adjuvant radio- and chemotherapies, the prognosis for patients with glioma remains poor. We have explored the effects of using genetically modified mesenchymal stem cells (MSCs) to treat malignant glioma in rats. Mesenchymal stem cells isolated from Sprague-Dawley rats can directly suppress the growth of C6 cells in vitro. MSCs transplanted intratumorally can also significantly inhibit the growth of glioma and prolong survival in C6 glioma-bearing models. MSCs producing Interleukin-18 infected by adenoviral vector inhibited glioma growth and prolonged the survival of glioma-bearing rats. Transplantation of IL-18 secreting MSCs was associated with enhanced T cell infiltration and long-term anti-tumor immunity. Thus, IL-18 may be an effective adoptive immunotherapy for malignant glioma. When used in conjunction with MSCs as targeting vehicles in vivo, IL-18 may offer a promising new treatment option for malignant glioma.
authors: Institute of Neuromedicine, South Medical University, Zhujiang Hospital, Guangzhou, China.
authors: Gang
authors: G
authors: Xu
authors: Xiao-Dan
authors: XD
authors: Jiang
authors: Ying
authors: Y
authors: Xu
authors: Jing
authors: J
authors: Zhang
authors: Fan-Heng
authors: FH
authors: Huang
authors: Zhen-Zhou
authors: ZZ
authors: Chen
authors: De-Xiang
authors: DX
authors: Zhou
authors: Jiang-Hua
authors: JH
authors: Shang
authors: Yu-Xi
authors: YX
authors: Zou
authors: Ying-Qian
authors: YQ
authors: Cai
authors: Sheng-Bin
authors: SB
authors: Kou
authors: Yi-Zhao
authors: YZ
authors: Chen
authors: Ru-Xiang
authors: RX
authors: Xu
authors: Yan-Jun
authors: YJ
authors: Zeng
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D015316:Genetic Therapy; D005822:Genetic Vectors; D005910:Glioma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D020382:Interleukin-18 / Q000235:genetics*; D053208:Kaplan-Meier Estimate; D016246:Lymphocytes, Tumor-Infiltrating / Q000378:metabolism; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000378:metabolism; D051379:Mice; D011859:Radiography; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D020382:Interleukin-18