Meta-analysis of SUMO1.
An abundantly growing body of literature implicates conjugation of SUMO in the regulation of many proteins and processes, yet the regulation of SUMO pathways is poorly understood. To gain insight into the players in the SUMO1 pathway I have performed an in-silico co-expression meta-analysis of SUMO1, comparing many different multi-microarray studies of various normal and human tumour tissues, from the Oncomine database. This serves as a data-driven predictor of pathway partners of SUMO1. While the data obtained need to be confirmed by future independent experiments and can currently only be considered a hypothesis, results implicate defender against cell death (DAD1) and the anti-apoptotic DEK oncogene as new pathway partners of SUMO1.
Wilson
Brian J
BJ
Molecular Oncology Group, Room H5-45, McGill University Health Centre, 687 Pine Avenue West, Montréal, Québec, H3A 1A1, Canada. brian.wilson2@mcgill.ca