[Advance of several types of important marine antitumor drugs].
Marine antitumor drugs have been the research focus in the world. Recently, advancement has been made in the investigation of six types of compounds including bryostatin-1, ecteinascidin-743, dolastatin, didemnin B, psammaplin and halichondrin B. In this review, we summarized the recent research progress of the above mentioned marine antitumor drugs and their derivatives. Also, the development tendency of marine antitumor drugs was discussed.
Zhang
Jian-Ye
JY
State Key laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, China.
Fu
Li-Wu
LW
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D001688:Biological Products / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D054713:Bryostatins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D047630:Depsipeptides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D004149:Dioxoles / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D004220:Disulfides / Q000302:isolation & purification / Q000494:pharmacology; D004988:Ethers, Cyclic / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D018942:Macrolides; D008386:Marine Biology; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D044005:Tetrahydroisoquinolines / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D000077606:Trabectedin; D014443:Tyrosine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D000095662:Polyether Polyketides
D000970:Antineoplastic Agents; D001688:Biological Products; D054713:Bryostatins; D047630:Depsipeptides; D004149:Dioxoles; D004220:Disulfides; D004988:Ethers, Cyclic; D018942:Macrolides; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin; D014443:Tyrosine; C098378:psammaplin A; C070519:halichondrin B; D000095662:Polyether Polyketides; C046785:bryostatin 1; C030051:didemnins; C064570:dolastatin 10