title: Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors.
abstract: The env open reading frames of African lion (Panthera leo) lentivirus (feline immunodeficiency virus [FIV(Ple)]) subtypes B and E from geographically distinct regions of Africa suggest two distinct ancestries, with FIV(Ple)-E sharing a common ancestor with the domestic cat (Felis catus) lentivirus (FIV(Fca)). Here we demonstrate that FIV(Ple)-E and FIV(Fca) share the use of CD134 (OX40) and CXCR4 as a primary receptor and coreceptor, respectively, and that both lion CD134 and CXCR4 are functional receptors for FIV(Ple)-E. The shared usage of CD134 and CXCR4 by FIV(Fca) and FIV(Ple)-E may have implications for in vivo cell tropism and the pathogenicity of the E subtype among free-ranging lion populations.
authors: Faculty of Veterinary Medicine, Retrovirus Research Laboratory, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow, United Kingdom.
authors: William A
authors: WA
authors: McEwan
authors: Elizabeth L
authors: EL
authors: McMonagle
authors: Nicola
authors: N
authors: Logan
authors: Rodrigo C
authors: RC
authors: Serra
authors: Pieter
authors: P
authors: Kat
authors: Sue
authors: S
authors: Vandewoude
authors: Margaret J
authors: MJ
authors: Hosie
authors: Brian J
authors: BJ
authors: Willett
mesh_terms: D000818:Animals; D002415:Cats / Q000821:virology*; D002460:Cell Line; D017930:Genes, Reporter; D015726:Giant Cells / Q000166:cytology / Q000821:virology; D016089:Immunodeficiency Virus, Feline / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D008045:Lions / Q000821:virology*; D008156:Luciferases / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics; D019718:Receptors, CXCR4 / Q000378:metabolism*; D053262:Receptors, OX40 / Q000378:metabolism*; D011991:Receptors, Virus; D017422:Sequence Analysis, DNA; D053586:Virus Internalization
chemical_list: D012367:RNA, Viral; D019718:Receptors, CXCR4; D053262:Receptors, OX40; D011991:Receptors, Virus; D008156:Luciferases