title: Antibacterial potential of Antarctic lichens against human pathogenic Gram-positive bacteria.
abstract: Extracts from five Antarctic lichens (L3, Stereocaulon alpinum; L5, Ramalina terebrata; L6, Caloplaca sp.; L8, Lecanora sp.; and L17, Caloplaca regalis) were tested for antimicrobial activities against several clinically important microbes by disk diffusion. The minimum inhibitory concentration (MIC) of each extract was determined by a broth dilution method. Extracts from L3, L5, L6 and L8 were active against two Gram(+) strains. B. subtilis was more sensitive to lichen extracts (except L5) than S. aureus. The MIC of lichen extracts against B. subtilis and S. aureus was observed from 36.7 +/- 0.3 to 953.8 +/- 85.8 microg/mL and 68.5 +/- 0.6 to >1000 microg/mL, respectively. Comparisons of MIC values of Antarctic lichen crude extracts to previously published MIC values of some reported lichen metabolites against Gram(+) bacteria indicated that Antarctic lichens might be an enriched source of effective antibacterial agents against clinically relevant Gram(+) species.
authors: Polar BioCenter, Korea Polar Research Institute, KORDI, Songdo Technopark, Songdo-dong 7-50, Yeonsu-gu, Incheon 406-840, South Korea.
authors: Babita
authors: B
authors: Paudel
authors: Hari Datta
authors: HD
authors: Bhattarai
authors: Jin Sung
authors: JS
authors: Lee
authors: Soon Gyu
authors: SG
authors: Hong
authors: Hyun Woung
authors: HW
authors: Shin
authors: Joung Han
authors: JH
authors: Yim
mesh_terms: D000864:Antarctic Regions; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008011:Lichens / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts