Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631.
Five chicken lines were experimentally infected with a HPAI H7N1 virus, to examine the variation in susceptibility to infection. Three lines showed high susceptibility to the virus, while two showed some resistance, with 7 out of 20, and 11 out of 15 birds, respectively, remaining healthy and surviving the experimental infection. Genotyping for the G/A polymorphism at position 2032 of Mx cDNA showed that one line was fixed for the G allele, and two were segregating for A and G alleles. Birds in the other two lines were selected to be fixed for the A allele. Statistical analyses indicated that the Mx genotype did not affect the clinical status or the time course of infection after viral inoculation.
Sironi
Laura
L
Parco Tecnologico Padano, CERSA, Polo Universitario, Lodi, Italy.
Williams
John L
JL
Moreno-Martin
Ana M
AM
Ramelli
Paola
P
Stella
Alessandra
A
Jianlin
Han
H
Weigend
Steffen
S
Lombardi
Guerino
G
Cordioli
Paolo
P
Mariani
Paola
P
D000596:Amino Acids / Q000235:genetics; D000818:Animals; D002645:Chickens / Q000276:immunology* / Q000821:virology; D004198:Disease Susceptibility; D019204:GTP-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D053126:Influenza A Virus, H7N7 Subtype / Q000235:genetics*; D005585:Influenza in Birds / Q000235:genetics / Q000821:virology; D009976:Orthomyxoviridae Infections / Q000235:genetics; D011110:Polymorphism, Genetic; D011201:Poultry Diseases / Q000235:genetics
D000596:Amino Acids; D019204:GTP-Binding Proteins