title: Effect of modified ultrafiltration on postoperative course in neonates with complete transposition of the great arteries undergoing arterial switch operation.
abstract: BACKGROUND
  The purpose of the present study was to evaluate the effect of modified ultrafiltration (MUF) on neonates with transposition of the great arteries (TGA) undergoing arterial switch operation.
  
  
  RESULTS
  The current study included 36 neonates who underwent an arterial switch operation between 1998 and 2006. Arterio-venous MUF was done in 15 patients (MUF-treated group) and the other 21 patients were controls. Parameters included hematocrit, hemodynamics, pulmonary function, drain loss, leak of peritoneal fluid, length of intubation, and intensive care unit (ICU) stay. The hematocrit increased from 34+/-2% to 47+/-4% in the MUF-treated group. Blood pressure in the MUF-treated group was significantly increased without any change of central venous or left atrial pressure. Post-operative oxygenation in the MUF-treated group was greater than that of the control group (P/F ratio: 258+/-92 vs 170+/-100 mmHg, p<0.05), which did not contribute to decrease in intubation time (54+/-33 vs 52+/-29 h, p=NS). Post-operative chest drain loss and peritoneal fluid leak were comparable. The ICU stay in the MUF-treated group was significantly shorter than that in the controls (101+/-34 vs 139+/-42 h, p<0.05).
  
  
  CONCLUSIONS
  MUF brought improvement in blood pressure and gas exchange capacity and subsequent shorter ICU stay. MUF did not have significant impact on intubation time and capillary leak.
authors: Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
authors: Yasuhiro
authors: Y
authors: Kotani
authors: Osami
authors: O
authors: Honjo
authors: Satoru
authors: S
authors: Osaki
authors: Takuya
authors: T
authors: Kawabata
authors: Shinya
authors: S
authors: Ugaki
authors: Yasuhiro
authors: Y
authors: Fujii
authors: Ko
authors: K
authors: Yoshizumi
authors: Shingo
authors: S
authors: Kasahara
authors: Kozo
authors: K
authors: Ishino
authors: Shunji
authors: S
authors: Sano
mesh_terms: D001794:Blood Pressure; D006348:Cardiac Surgical Procedures; D003422:Critical Care; D005260:Female; D006400:Hematocrit; D006440:Hemofiltration; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D014188:Transposition of Great Vessels / Q000503:physiopathology / Q000601:surgery*