Neuropsychological impairment and psychosis in mania.
Deficits involving executive function, working memory, speed of information processing, and new learning occur in many people with mania. Factors that predict impairment remain poorly understood, but there are indications that psychotic features may correspond with increased risk of neurocognitive dysfunction during manic episodes. The current study examined neuropsychological function in 40 inpatients with bipolar I mania, 24 of whom presented with psychotic features. Compared to a control group, the inpatients showed worse executive function, speed of information processing, new learning, and dexterity. Nonetheless, presence of psychotic features failed to distinguish the inpatients with mania. Thus, psychotic features do not appear to increase neurobehavioral morbidity in people with mania, but presence of mania clearly corresponded with neurobehavioral dysfunction. Implications of these data for clinical practice and our understanding of bipolar disorder are discussed.
Basso
Michael R
MR
Department of Psychology, University of Tulsa, Tulsa, OK 74104, USA. michael-basso@utulsa.edu
Lowery
Natasha
N
Ghormley
Courtney
C
Ward
Taeh
T
Purdie
Rod
R
Neel
Jackie
J
Combs
Dennis R
DR
Bornstein
Robert A
RA
D000328:Adult; D001714:Bipolar Disorder / Q000150:complications*; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D010555:Personality Inventory; D011340:Problem Solving / Q000502:physiology; D011618:Psychotic Disorders / Q000209:etiology*; D012189:Retrospective Studies