Use of YbIII-centered near-infrared (NIR) luminescence to determine the hydration state of a 3,2-HOPO-based MRI contrast agent.
The synthesis, structure, and characterization of a [Yb(Tren-Me-3,2-HOPO)(H 2O) 2] complex are reported. As a result of its Yb (III) emission in the near-infrared region, sensitized by the Me-3,2-HOPO chromophore, this complex can be utilized for the first time to determine the hydration state, q, via the luminescence lifetimes and hence the solution structure of these Me-3,2-HOPO-type ligands, which have attracted significant interest in complex with Gd (III) as possible next-generation magnetic resonance imaging contrast agents.
Moore
Evan G
EG
Department of Chemistry, University of California, Berkeley, California 94720, and the Chemical Sciences Division, Glenn T. Seaborg Center, Lawrence Berkeley National Laboratory, Berkeley, California 94720
Seitz
Michael
M
Raymond
Kenneth N
KN
D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D007259:Infrared Rays; D049449:Luminescence; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry*; D014867:Water / Q000737:chemistry*; D015018:Ytterbium / Q000737:chemistry*
D003287:Contrast Media; D009942:Organometallic Compounds; D011728:Pyridones; D014867:Water; D015018:Ytterbium