Efficiency of intermittent exercise on adiposity and fatty liver in rats fed with high-fat diet.
OBJECTIVE
This study aimed to examine and compare the effects of continuous or intermittent exercises on adiposity and fatty liver in rats fed with high-fat diet.


METHODS
Wistar rats were divided according to diet composition-chow diet (C) or high-fat diet (H)-and kinds of exercise-sedentary (S), continuous (CE), or intermittent (IE) exercises. The CE group swam 90 min/day, and the IE group swam 3 x 30 min/day (at 4-h intervals between sessions); both groups exercised 5 days/week during 8 weeks. Body weight and food intake were recorded daily. Lipogenesis rate in vivo was determined by the incorporation of (3)H(2)O into saponified lipids in retroperitoneal (RET), epididymal (EPI), and visceral (VIS) white adipose tissues, brown adipose tissue (BAT), liver (L), and gastrocnemius muscle (GAST) using the gravimetric method. Total cholesterol, high-density lipoprotein (HDL)-cholesterol, and triacylglycerol (TG) were analyzed.


RESULTS
The major finding of this study is that IE was more efficient than CE in reducing the adverse effects of high-fat diet and sedentarism. There was an improvement in the lipid profile and a reduction in food intake, body weight gain, visceral and central adiposity, and fatty liver, contributing to the control of obesity and other comorbidities, including nonalcoholic fat liver diseases.


CONCLUSIONS
Earlier studies have discussed the effects of diet consumption on adiposity and their relation to chronic diseases and obesity. This study discusses the effects of high-fat diet consumption and the different kinds of exercise on weight gain, adiposity, fatty liver, and lipid profile in rats. The results may depend on the exercise, time of each session, age, gender, and experimental period.
Sene-Fiorese
Marcela
M
Department of Physical Education, Center of Biological and Health Sciences, Federal University of São Carlos, São Paulo, Brazil.
Duarte
Fernanda O
FO
Scarmagnani
Flavia R R
FR
Cheik
Nadia C
NC
Manzoni
Marla S J
MS
Nonaka
Keico O
KO
Rossi
Eliseu A
EA
de Oliveira Duarte
Ana C G
AC
Dâmaso
Ana R
AR
D000273:Adipose Tissue / Q000378:metabolism; D050154:Adiposity; D000818:Animals; D004041:Dietary Fats; D004195:Disease Models, Animal; D004435:Eating; D002149:Energy Intake; D005081:Exercise Therapy / Q000379:methods; D005234:Fatty Liver / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D008055:Lipids / Q000097:blood; D050155:Lipogenesis; D008099:Liver / Q000378:metabolism*; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D005082:Physical Exertion; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain
D004041:Dietary Fats; D008055:Lipids