Spontaneous formation of bilayers and vesicles in mixtures of single-chain alkyl carboxylates: effect of pH and aging and cytotoxicity studies.
We report the observation of bilayer fragments, some of which close to form vesicles, over a large range of pH at room temperature from mixtures of single-chain biocompatible commercially available nontoxic alkyl carboxylic surfactants after neutralization with HCl. The pH at which the morphological transitions occur is varied only by changing the ratio between two surfactants: the alkyloligoethyleneoxide carboxylate and sodium laurate. The effect of aging of the mixed surfactant systems in the pH region desired for dermatologic application (4.5 < pH < 7) is also studied. Finally, we show results of cytotoxicity studies on the surfactant mixtures.
Vlachy
N
N
Institute of Physical and Theoretical Chemistry and Department of Pharmaceutical Biology, University of Regensburg, Regensburg, Germany,
Merle
C
C
Touraud
D
D
Schmidt
J
J
Talmon
Y
Y
Heilmann
J
J
Kunz
W
W
D001672:Biocompatible Materials / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D020285:Cryoelectron Microscopy; D006367:HeLa Cells; D006801:Humans; D006851:Hydrochloric Acid / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007850:Lauric Acids / Q000737:chemistry; D008027:Light; D008051:Lipid Bilayers / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D044367:Phase Transition; D013501:Surface-Active Agents; D013778:Tetrazolium Salts / Q000737:chemistry / Q000494:pharmacology; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology; D013997:Time Factors
D001672:Biocompatible Materials; D002264:Carboxylic Acids; D007850:Lauric Acids; D008051:Lipid Bilayers; D013501:Surface-Active Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; C030358:lauric acid; C022616:thiazolyl blue; D006851:Hydrochloric Acid