title: Genistein protects the kidney from cisplatin-induced injury.
abstract: Oxidative stress and inflammation contribute to the pathogenesis of cisplatin-induced nephrotoxicity. We found that genistein, a tyrosine kinase inhibitor with broad specificities, and which also has estrogen-like activity, had protective effects on cisplatin-induced renal injury in mice. Genistein significantly decreased reactive oxygen species production, the expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 proteins, as well as the translocation of the p65 subunit of nuclear factor-kappaB into the nucleus and the infiltration of macrophages, all of which were increased in the kidney by cisplatin treatment. Genistein also decreased cisplatin-induced apoptosis by regulating p53 induction in kidney. Genistein significantly reduced reactive oxygen species production in cisplatin-treated normal human kidney HK-2 cells. These studies show that genistein or similar compounds might be useful in prevention of cisplatin-induced renal injury.
authors: Food Function Research Center, Korea Food Research Institute, Seongnam, Gyeongki, Republic of Korea.
authors: Mi Jeong
authors: MJ
authors: Sung
authors: Duk Hoon
authors: DH
authors: Kim
authors: Yu Jin
authors: YJ
authors: Jung
authors: Kyung Pyo
authors: KP
authors: Kang
authors: Ae Sin
authors: AS
authors: Lee
authors: Sik
authors: S
authors: Lee
authors: Won
authors: W
authors: Kim
authors: Munkhtugs
authors: M
authors: Davaatseren
authors: Jin-Taek
authors: JT
authors: Hwang
authors: Hyun-Jin
authors: HJ
authors: Kim
authors: Myung Sunny
authors: MS
authors: Kim
authors: Dae Young
authors: DY
authors: Kwon
authors: Sung Kwang
authors: SK
authors: Park
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000032:analysis; D002460:Cell Line; D002945:Cisplatin / Q000009:adverse effects*; D019833:Genistein / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D051379:Mice; D017382:Reactive Oxygen Species / Q000032:analysis; D051996:Transcription Factor RelA / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D017382:Reactive Oxygen Species; D051996:Transcription Factor RelA; D019833:Genistein; D002945:Cisplatin