title: Clinical and microbiological effects of an essential-oil-containing mouth rinse applied in the "one-stage full-mouth disinfection" protocol--a randomized doubled-blinded preliminary study.
abstract: The aim of this randomized double-blinded preliminary study was to evaluate the clinical and microbiological long-term effects of an essential-oil-containing mouth rinse as the active agent utilized in the "one-stage full-mouth disinfection protocol." Probing pocket depth and plaque and gingival indices were evaluated by the same calibrated examiner in all teeth of 20 moderate chronic periodontitis subjects. Presence of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythensis were determined by polymerase chain reaction in nonstimulated saliva, tongue dorsum, and pooled subgingival samples. The subjects were randomized into two groups: full-mouth disinfection plus essential oils (Listerine) or full-mouth disinfection plus placebo. Clinical and microbial parameters were evaluated at baseline (T0), 45 (T1) and 180 (T2) days after therapy and analyzed using analysis of variance, Student t, and Wilcoxon tests (p < 0.05). No significant differences were observed between groups regarding clinical measurements at baseline. However, in the later examinations, T1 and T2, the test group always presented higher reductions of pocket depth, plaque index, and gingival index compared to the control group. The essential-oils group revealed significant reduction on occurrence of P. gingivalis in saliva comparing baseline and 45 days; this difference still remain at 180 days. The essential-oil-containing mouth rinse demonstrated beneficial effects on clinical parameters. Microbiological findings were less consistent. The results of this preliminary study suggest further investigations.
authors: Department of Periodontology and Preventive Dentistry, Dental Research Division, University of Taubaté, Taubaté, Sao Paolo, Brazil. cavalcacortelli@uol.com.br
authors: Sheila
authors: S
authors: Cavalca Cortelli
authors: Fabiana
authors: F
authors: Cavallini
authors: Marcello Faria
authors: MF
authors: Regueira Alves
authors: Arnaud
authors: A
authors: Alves Bezerra
authors: Celso Silva
authors: CS
authors: Queiroz
authors: José Roberto
authors: JR
authors: Cortelli
mesh_terms: D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects; D000891:Anti-Infective Agents, Local / Q000494:pharmacology / Q000627:therapeutic use*; D001439:Bacteroides / Q000187:drug effects; D055113:Chronic Periodontitis / Q000188:drug therapy*; D003773:Dental Plaque / Q000382:microbiology* / Q000517:prevention & control; D003774:Dental Plaque Index; D012534:Dental Scaling; D004311:Double-Blind Method; D004338:Drug Combinations; D006801:Humans; D009067:Mouthwashes / Q000494:pharmacology / Q000627:therapeutic use*; D009822:Oils, Volatile / Q000494:pharmacology / Q000627:therapeutic use*; D010512:Periodontal Index; D010865:Pilot Projects; D016966:Porphyromonas gingivalis / Q000187:drug effects; D012459:Salicylates / Q000494:pharmacology / Q000627:therapeutic use; D012463:Saliva / Q000382:microbiology; D013729:Terpenes / Q000494:pharmacology / Q000627:therapeutic use; D007507:Therapeutic Irrigation
chemical_list: D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D009067:Mouthwashes; D009822:Oils, Volatile; D012459:Salicylates; D013729:Terpenes; C057473:Listerine