title: Giant cell aortitis and Noonan syndrome.
abstract: An 18-year-old girl with Noonan syndrome was diagnosed with progressive aneurysmal dilatation of the ascending aorta. Histopathological examination revealed giant cell aortitis. Connective tissue abnormalities leading to aortic root dilatation and the sinuses of Valsalva aneurysm have been reported in Noonan syndrome. This report is the first description of giant cell aortitis in Noonan syndrome and may provide a link between aortic aneurysm, and giant cell granuloma of bone in Noonan syndrome.
authors: Mayo Congenital Heart Center, Mayo Clinic, Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Rochester, MN 55905, USA. menon.shaji@mayo.edu
authors: Shaji
authors: S
authors: Menon
authors: Mary E
authors: ME
authors: Pierpont
authors: David
authors: D
authors: Driscoll
mesh_terms: D000293:Adolescent; D001014:Aortic Aneurysm / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D015897:Comorbidity; D005260:Female; D013700:Giant Cell Arteritis / Q000453:epidemiology*; D006801:Humans; D018810:Magnetic Resonance Angiography; D009634:Noonan Syndrome / Q000453:epidemiology* / Q000473:pathology