Gle1 does double duty.
During nuclear export, Gle1 (the nuclear-pore-associated mRNA export factor) activates the DEAD-box protein Dbp5 to remodel exported mRNA-protein complexes on the cytoplasmic face of the nuclear pore complex. In this issue, Bolger et al. (2008) now report additional roles for Gle1 in translation initiation and termination.
Kutay
Ulrike
U
Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, CH-8093 Zürich, Switzerland. ulrike.kutay@bc.biol.ethz.ch
Panse
Vikram Govind
VG
D002352:Carrier Proteins / Q000378:metabolism*; D008954:Models, Biological; D028861:Nuclear Pore Complex Proteins; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
D002352:Carrier Proteins; C101408:GLE1 protein, S cerevisiae; D028861:Nuclear Pore Complex Proteins; D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins