Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.
Genome-wide association studies are discovering relationships between single-nucleotide polymorphisms and breast cancer, but the functions of these single-nucleotide polymorphisms are unknown and environmental exposures are likely to be important. We assessed whether breast cancer risk single-nucleotide polymorphisms interacted with ionizing radiation, a known breast carcinogen, among 859 cases and 1,083 controls nested in the U.S. Radiologic Technologists cohort. Among 11 Breast Cancer Association Consortium risk single-nucleotide polymorphisms, we found that the genotype-associated breast cancer risk varied significantly by radiation dose for rs2107425 in the H19 gene (P(interaction) = 0.001). H19 is a maternally expressed imprinted mRNA that is closely involved in regulating the IGF2 gene and could exert its influence by this or by some other radiation-related pathway.
Bhatti
Parveen
P
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892-7238, USA. bhattip@mail.NIH.gov
Doody
Michele M
MM
Alexander
Bruce H
BH
Yuenger
Jeff
J
Simon
Steven L
SL
Weinstock
Robert M
RM
Rosenstein
Marvin
M
Stovall
Marilyn
M
Abend
Michael
M
Preston
Dale L
DL
Pharoah
Paul
P
Struewing
Jeffery P
JP
Sigurdson
Alice J
AJ
D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics* / Q000401:mortality; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000235:genetics* / Q000401:mortality; D016273:Occupational Exposure / Q000009:adverse effects*; D020641:Polymorphism, Single Nucleotide; D011839:Radiation, Ionizing; D014481:United States