title: Clinicopathological and immnuohistochemical findings in a series of folliculosebaceous cystic hamartoma.
abstract: BACKGROUND
  Folliculo-sebaceous cystic hamartoma (FSCH) is an uncommon skin condition presenting as a slow-growing papulo-nodular lesion, in or around the nose. Most cases are not clinically suspected and only histopathological examination allows the diagnosis. Pathological features include a dermal-located infundibulo-cystic structure with sebaceous glands radiating around, a stromal component encircling the epithelial structures, with clefts between the lesional epithelial and stromal parts, as well as between this and the adjacent dermis.
  
  
  RESULTS
  We report eight patients with the diagnosis of FSCH (5 females and 3 males), with ages ranging from 35 to 77 years. Most cases (5 out of 8) were located in or around the nose and sizes were comprised between 0.6 and 1.2 cm. Lesions had grown for long periods of time, up to ten years in one case. Immunohistochemistry showed staining for p63 in the epithelial component of all lesions, while CD10 was only present in some sebocytes. CD34 and Factor XIIIa positive cells were present in the lesional stroma. Staining for androgen and alpha-estrogen receptors was also usually noticed.
  
  
  CONCLUSIONS
  FCSH is a hamartomatous skin lesion, clinically indistinct but with well-defined histopathological features. Immunohistochemistry shows a profile very close to normal sebaceous glands.
authors: Department of Pathology, University Hospital and School of Medicine, Santiago de Compostela, Spain. jsuarezp@usc.es
authors: Jose M
authors: JM
authors: Suarez-Peñaranda
authors: Begoña
authors: B
authors: Vieites
authors: Aquilina
authors: A
authors: Ramírez-Santos
authors: Virginia
authors: V
authors: Fernández-Redondo
authors: Jaime
authors: J
authors: Toribio
authors: Emilo
authors: E
authors: Del Rio
authors: Jerónimo
authors: J
authors: Forteza-Vila
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D004814:Epidermal Cyst / Q000378:metabolism / Q000473:pathology; D026122:Factor XIIIa / Q000378:metabolism; D005260:Female; D006222:Hamartoma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D015260:Neprilysin / Q000378:metabolism; D009669:Nose Neoplasms / Q000378:metabolism / Q000473:pathology; D011944:Receptors, Androgen / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D012626:Sebaceous Gland Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D018952:Antigens, CD34; C081876:CKAP4 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D026122:Factor XIIIa; D015260:Neprilysin