title: Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa.
abstract: OBJECTIVE
  To assess the correlation between macular morphology and visual acuity in retinitis pigmentosa (RP) patients with cystoid macular oedema (CME).
  
  
  METHODS
  Retrospective cross-sectional study.
  
  
  METHODS
  Forty-one eyes of 25 RP patients with CME. Patients underwent cross-sectional scans with optical coherence tomography (Stratus OCT). Age, total retinal thickness, photoreceptor thickness, and the transverse and vertical lengths of the cystoid space were measured. Correlation between visual acuity and each of the measurements were examined. Additionally, the status of the inner segment/outer segment junction (IS/OS) was classified as being absent, discontinuous, or distinct. Measurements were then compared among the three groups.
  
  
  RESULTS
  Total retinal thickness or photoreceptor thickness was not correlated with visual acuity. There was a correlation between the transverse length of the cystoid space and visual acuity, although the correlation coefficient was weak (r=0.30). The logMAR visual acuity in the IS/OS absent group (0.67+/-0.43) was worse than that seen in the IS/OS discontinuous (0.22+/-0.19) or IS/OS distinct groups (0.07+/-0.16) (P<0.001).
  
  
  CONCLUSIONS
  When monitoring CME associated with RP, the status of IS/OS is the essential parameter that needs to be examined.
authors: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors: A
authors: A
authors: Oishi
authors: A
authors: A
authors: Otani
authors: M
authors: M
authors: Sasahara
authors: H
authors: H
authors: Kojima
authors: H
authors: H
authors: Nakamura
authors: M
authors: M
authors: Kurimoto
authors: N
authors: N
authors: Yoshimura
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005584:Fovea Centralis / Q000473:pathology; D006801:Humans; D008269:Macular Edema / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology*; D012160:Retina / Q000473:pathology; D012174:Retinitis Pigmentosa / Q000150:complications*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*