title: Apolipoprotein J and leptin levels in patients with coronary heart disease.
abstract: BACKGROUND
  Preliminary data suggest that apolipoprotein J (ApoJ) may play a role in the development and progression of atherosclerosis. Leptin, an adipose tissue hormone, exerts important cardiovascular effects. The association between serum ApoJ and leptin concentrations was assessed in patients with established or suspected coronary heart disease (CHD).
  
  
  METHODS
  Serum ApoJ and leptin concentrations were evaluated in 67 CHD patients undergoing coronary angiography [54 individuals with significant (> or =50%) coronary artery stenosis and 13 patients without significant coronary artery stenosis on angiography].
  
  
  RESULTS
  Serum ApoJ concentrations in patients with significant coronary artery stenosis were significantly higher than in those without (303.9+/-118.6 vs. 121.2+/-37.5 microg/mL, respectively; p<0.001). The reverse pattern was observed for serum leptin levels (8.6+/-5.5 vs. 20.6+/-17.1 ng/ml, respectively; p=0.016). There was a significant negative correlation between ApoJ and leptin levels (r=-0.353; p=0.003).
  
  
  CONCLUSIONS
  ApoJ and leptin may be markers for CHD.
authors: Department of Experimental Surgery and Surgical Research N.S. Christeas, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors: Maria V
authors: MV
authors: Poulakou
authors: Kosmas I
authors: KI
authors: Paraskevas
authors: Mark R
authors: MR
authors: Wilson
authors: Dimitrios C
authors: DC
authors: Iliopoulos
authors: Christos
authors: C
authors: Tsigris
authors: Dimitri P
authors: DP
authors: Mikhailidis
authors: Despina
authors: D
authors: Perrea
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D051152:Clusterin / Q000097:blood*; D017023:Coronary Angiography / Q000379:methods; D003327:Coronary Disease / Q000097:blood* / Q000175:diagnosis; D023921:Coronary Stenosis / Q000097:blood / Q000175:diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological
chemical_list: D015415:Biomarkers; D051152:Clusterin; D020738:Leptin