title: The discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis.
abstract: 1The traditional view of calcium homeostasis is that it is maintained by two essential reactions. First, changes in extracellular Ca2+ are sensed in several distinct cell types, stimulating the secretion of parathyroid hormone (PTH), 1,25(OH)(2) D and calcitonin in response to the body's requirement. Second, these calcitropic hormones then act on the calcium-translocating cells of the kidney, bone, and intestine to restore calcium balance. Recent progress indicates that alpha-Klotho and fibroblast growth factor (FGF) 23 are key players that integrate the multi-step regulatory system of calcium homeostasis that rapidly adjusts the extracellular calcium concentration and continuously maintains its concentration within a narrow physiological range. alpha-Klotho and FGF23 are also found to be major players in the regulatory system of phosphate homeostasis. Here, the demonstration of the molecular functions of alpha-Klotho and FGF23 has recently given new insight into the field of calcium and phosphate homeostasis.
authors: Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Yoshida Konoe-cho Sakyu-ku, Kyoto, 606 - 8501, Japan. nabemr@lmls.med.kyoto-u.ac.jp
authors: Y
authors: Y
authors: Nabeshima
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D000090265:Klotho Proteins; D010710:Phosphates / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: C000717427:FGF23 protein, human; D010710:Phosphates; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins; D000254:Sodium-Potassium-Exchanging ATPase; D002118:Calcium