Antidepressant prescription and suicide rates: effect of age and gender.
To determine whether the effect of antidepressant exposure on suicide rate is modified by age and gender in Hungary, annual antidepressant prescription rates and suicide rates of about 10 million inhabitants between 1999-2005 were analyzed by age and gender groups. The suicide rate was inversely related to the increased use of antidepressants in both genders. The strongest association was found in the oldest age groups, where the increase in antidepressant use was highest, while there was no association in the under 20 or 50-69 age groups in either gender. Antidepressant prescription rate was related to suicide rate after controlling for divorce rate or unemployment rate, but not after controlling for alcohol consumption rate.
Kalmar
Sandor
S
Semmelweis Hospital, Kiskunhalas, Hungary.
Szanto
Katalin
K
Rihmer
Zoltan
Z
Mazumdar
Sati
S
Harrison
Katrin
K
Mann
J John
JJ
D000063:Accidents, Traffic / Q000401:mortality; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000523:psychology; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy / Q000523:psychology; D004243:Divorce / Q000706:statistics & numerical data; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D004363:Drug Utilization; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017678:Sex Distribution; D012737:Sex Factors; D013405:Suicide / Q000523:psychology / Q000706:statistics & numerical data*; D016896:Treatment Outcome; D014478:Unemployment / Q000706:statistics & numerical data; D000092864:Suicide Prevention
D000928:Antidepressive Agents