title: Association between lactate concentration in amniotic fluid and dysfunctional labor.
abstract: OBJECTIVE
  To assess whether there is an association between high lactate concentration in amniotic fluid (AF) and labor dystocia.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Labor ward at General South Hospital, Stockholm, Sweden.
  
  
  METHODS
  Women in active labor attending labor ward, having at least two consecutive measurements of lactate concentration in AF, measured 60 minutes apart.
  
  
  METHODS
  Dysfunctional labor, defined as instrumental or operative delivery due to dystocia.
  
  
  RESULTS
  Among women with spontaneous vaginal deliveries (n=23) the mean lactate concentration in AF during labor was 8.9 mmol/l (range 6.6-10.8), and among women with operative delivery due to labor dystocia (n=31) the corresponding value was 10.9 mmol/l (range 8.0-16.1) (p<0.001). Of 29 women with a high lactate concentration (> or =10.1 mmol/l) in at least two consecutive measures collected at least 60 minutes apart, 25 (86%) were delivered instrumentally/operatively due to dystocia. Using this definition of a positive test, the diagnostic accuracy to predict operative delivery due to dystocia was: sensitivity 81% (25/31), specificity 83% (19/23), positive predictive value 86% (25/29), and negative predictive value 76% (19/25). The likelihood ratio was 5.0 for a positive test and 0.2 for a negative test.
  
  
  CONCLUSIONS
  High lactate concentration (> or =10.1mmol/l) in at least two consecutive samples of AF collected during labor 60 minutes apart is strongly associated with dystocia. This method might be useful in clinical management to identify labor dystocia at an early stage of labor.
authors: Department of Clinical Science and Education, Section of Obstetrics and Gynaecology, Karolinska Institute at Stockholm Söder Hospital, Sweden. eva.itzel@telia.com
authors: Eva
authors: E
authors: Wiberg-Itzel
authors: Hans
authors: H
authors: Pettersson
authors: Sven
authors: S
authors: Cnattingius
authors: Lennart
authors: L
authors: Nordström
mesh_terms: D000653:Amniotic Fluid / Q000737:chemistry / Q000378:metabolism*; D004420:Dystocia / Q000378:metabolism*; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D019344:Lactic Acid