[Clonal association of flat epithelial atypia and tubular breast cancer].
Flat epithelial atypia (FEA) of the breast has recently gained attention as a possible precursor lesion of highly differentiated breast cancer. Especially tubular carcinomas, with which FEA shares cytological features, often occur in close proximity to each other. To examine a possible clonal relationship, we analysed mutations of the highly variable region of the mitochondrial genome in a series of tubular carcinomas, associated FEA and normal glands. Multiple sequence alignment showed identical mtDNA mutations in approximately 50% of paired FEA and tumour samples, indicative of a clonal relationship. Our data indicate a possible precursor role of FEA in the development of tubular breast cancer.
Aulmann
S
S
Pathologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 220/221, 69120 Heidelberg. sebastian.aulmann@med.uni-heidelberg.de
Elsawaf
Z
Z
Penzel
R
R
Schirmacher
P
P
Sinn
H P
HP
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002114:Calcinosis / Q000235:genetics / Q000473:pathology; D002467:Cell Nucleus / Q000235:genetics / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000235:genetics*; D004847:Epithelial Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D017422:Sequence Analysis, DNA
D004272:DNA, Mitochondrial