title: Preservation of duplicate genes by originalization.
abstract: Neofunctionalization, subfunctionalization and increasing gene dosage were proposed to be the possible ways to explain duplicate-gene preservation in previous studies. However, in some natural populations, such as yeast Saccharomyces cerevisiae, a considerable proportion of the duplicate genes originated from ancient whole genomic duplication (WGD) is preserved till now, which cannot be sufficiently explained by these mechanisms. In this article, we present another possible way to explain this conundrum-originalization, by which duplicate genes are both preserved intact at a high frequency in the population under only purifying selection. With approximate equal rates of mutation at the two duplicated loci, analytical, numerical and simulation results consistently show that the mean time to nonfunctionalization for unlinked haploinsufficient gene duplication might become markedly prolonged, which results from originalization. These theoretical results imply that originalization might be an alternative effective and temporary way of preserving duplicate genes.
authors: College of Life Sciences, University of Sun Yet-Sen, Guangzhou, China, lflf27@yahoo.com.cn.
authors: Cheng
authors: C
authors: Xue
authors: Yunxin
authors: Y
authors: Fu
mesh_terms: D003198:Computer Simulation; D019143:Evolution, Molecular; D020440:Gene Duplication; D020131:Genes, Duplicate / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D012641:Selection, Genetic