[Pathogenesis of ophthalmoherpes basing on the analysis of enzymes of the eye tissue and fluids].
To specify mechanisms of pathology development, we studied the activity of lysosomal glycosides in rabbit ocular tissues in experimental ophthalmoherpes. Rabbits with herpetic kepatitis show activation of beta-glucuronidase, beta-glycosidase, alpha-mannosidase in cornial epithelium and stroma, iris, aqueous humor of herpes-infected and contralateral eye. The activity of the above three glycosidases in the tears of children with herpetic keratitis was enhanced. If their activity does not regress after the treatment, ophthalmoherpes recurrence may be expected in the near future. For realization of its genetic program herpes simplex virus in infected cells activates synthesis of acid glycosidases this leading to degradation of cornial cell membranes, virus spread in the tissues and release of lysosomal enzymes into tear fluid.
Terekhina
N A
NA
Petrovich
Iu A
IuA
Reuk
S E
SE
D000818:Animals; D005123:Eye / Q000201:enzymology* / Q000473:pathology / Q000821:virology; D006026:Glycoside Hydrolases / Q000378:metabolism*; D006027:Glycosides / Q000378:metabolism*; D016849:Keratitis, Herpetic / Q000201:enzymology* / Q000473:pathology / Q000821:virology; D008247:Lysosomes / Q000201:enzymology* / Q000821:virology; D011817:Rabbits; D018139:Simplexvirus / Q000201:enzymology*; D013666:Tears / Q000201:enzymology / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism*
D006027:Glycosides; D014764:Viral Proteins; D006026:Glycoside Hydrolases