title: Anticipation of interoceptive threat in highly anxiety sensitive persons.
abstract: Anticipatory anxiety plays a major role in the etiology of panic disorder. Although anticipatory anxiety elicited by expectation of interoceptive cues is specifically relevant for panic patients, it has rarely been studied. Using a population analogue in high fear of such interoceptive arousal sensations (highly anxiety sensitive persons) we evaluated a new experimental paradigm to assess anticipatory anxiety during anticipation of interoceptive (somatic sensations evoked by hyperventilation) and exteroceptive (electric shock) threat. Symptom reports, autonomic arousal, and defensive response mobilization (startle eyeblink response) were monitored during threat and matched safe conditions in 26 highly anxiety sensitive persons and 22 controls. The anticipation of exteroceptive threat led to a defensive and autonomic mobilization as indexed by a potentiation of the startle response and an increase in skin conductance level in both experimental groups. During interoceptive threat, however, only highly anxiety sensitive persons but not the controls exhibited a startle response potentiation as well as autonomic activation. The anticipation of a hyperventilation procedure thus seems a valid paradigm to investigate anticipatory anxiety elicited by interoceptive cues in the clinical context.
authors: University of Greifswald, Department of Biological and Clinical Psychology, Franz-Mehring-Strasse 47, 17487 Greifswald, Germany. melzig@uni-greifswald.de
authors: Christiane A
authors: CA
authors: Melzig
authors: Jaroslaw M
authors: JM
authors: Michalowski
authors: Katharina
authors: K
authors: Holtz
authors: Alfons O
authors: AO
authors: Hamm
mesh_terms: D001007:Anxiety / Q000175:diagnosis* / Q000523:psychology; D003463:Cues; D004597:Electroshock / Q000523:psychology*; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006985:Hyperventilation / Q000523:psychology*; D008297:Male; D016584:Panic Disorder / Q000175:diagnosis* / Q000523:psychology; D013216:Reflex, Startle / Q000502:physiology; D013334:Students; D011795:Surveys and Questionnaires; D055815:Young Adult