Enantioselective synthesis utilizing enantiomorphous organic crystal of achiral benzils as a source of chirality in asymmetric autocatalysis.
Chiral crystals of achiral benzils act as efficient chiral initiators of asymmetric autocatalysis to afford highly enantioenriched pyrimidyl alkanols whose absolute configurations depend upon the enantiomorph of the crystal used in conjunction with asymmetric autocatalysis with amplification of enantiomeric excess.
Kawasaki
Tsuneomi
T
Department of Applied Chemistry, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo, 162-8601 Japan.
Harada
Yuuki
Y
Suzuki
Kenta
K
Tobita
Takayuki
T
Florini
Nicola
N
Pályi
Gyula
G
Soai
Kenso
K
D002384:Catalysis; D010658:Phenylglyoxal / Q000031:analogs & derivatives* / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
D011743:Pyrimidines; C030986:pyrimidine; D010658:Phenylglyoxal; C006697:benzil