Gut hormones in relation to body mass and torpor pattern changes during food restriction and re-feeding in the gray mouse lemur.
Potential implications of gut hormones in body mass and torpor and behavioral pattern changes induced by an incremental (40 and 80%) calorie restriction (CR) in long-days (LD, summer) and short-days (SD, winter) were investigated in gray mouse lemurs. Only 80% food-deprived LD and SD animals showed a continuous mass loss resulting in a 10 and 15% mass reduction, respectively. Ghrelin levels of all food-deprived groups increased by 2.6-fold on average and remained high after re-feeding while peptide YY (PYY) levels increased by 3.8-fold only in LD animals under 80% CR. In the re-fed SD group, body mass was positively associated with ghrelin and negatively associated with PYY, while no correlations were noted in the re-fed LD animals. Plasma glucagon-like peptide-1 (GLP-1) increased by 2.9-fold only in LD food-restricted mouse lemurs and was negatively associated with the minimal body temperature. No significant correlations were reported in food-deprived SD animals. These results suggest that ghrelin, PYY and GLP-1 may be related to pre-wintering fattening mechanisms and to the modulation of torpor expression, respectively. Such observation clearly warrants further investigations, but it opens an interesting area of research in torpor regulation.
Giroud
Sylvain
S
Mécanismes Adaptatifs et Evolution, UMR 7179 CNRS, Muséum National d'Histoire Naturelle, 4 Avenue du Petit Château, Brunoy, France.
Perret
Martine
M
Le Maho
Yvon
Y
Momken
Iman
I
Gilbert
Caroline
C
Blanc
Stéphane
S
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature; D001835:Body Weight; D016565:Cheirogaleidae / Q000378:metabolism*; D004435:Eating / Q000502:physiology*; D005508:Food Deprivation / Q000502:physiology*; D005768:Gastrointestinal Hormones / Q000502:physiology*; D054439:Ghrelin / Q000378:metabolism; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D007035:Hypothermia / Q000503:physiopathology; D009043:Motor Activity / Q000502:physiology; D019894:Peptide YY / Q000378:metabolism; D012621:Seasons
D005768:Gastrointestinal Hormones; D054439:Ghrelin; D019894:Peptide YY; D052216:Glucagon-Like Peptide 1