title: Clinical manifestations and characteristics of patients with acute generalized exanthematous pustulosis in Asia.
abstract: Acute generalized exanthematous pustulosis is a rare, sterile inflammation of the skin (and mucous membranes) characterized by acute onset of generalized pustule formation, fever and leukocytosis, and a rapid resolution. A computer-based search of the literature revealed only a limited series of reports, none of them based on Asian patients. We identified and retrospectively analysed 16 biopsy-proven and criteria-matched patients over a 15-year period in a single medical centre. The study showed a female predominance (11 of 16 patients), a relatively low association with systemic drugs (62.5% vs. 87% in a previous report) and normal renal function (in contrast to a previous report where 32% of patients had renal failure). The study also revealed high levels of C-reactive protein (76.0 mg/l) and normal absolute eosinophil count (176.2/microl) in most patients. Furthermore, there was no difference between different treatment regimens regard-ing the course and duration of the disease or the length of fever (p>0.05). In addition, if the patients were subdivided by aetiology into those strongly associated with or not strongly associated with systemic drugs, a significant difference was found in age of onset between the 2 groups (p<0.01).
authors: Department of Dermatology, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taipei, Taiwan.
authors: Shyue-Luen
authors: SL
authors: Chang
authors: Yu-Huei
authors: YH
authors: Huang
authors: Chih-Hsun
authors: CH
authors: Yang
authors: Sindy
authors: S
authors: Hu
authors: Hong-Shang
authors: HS
authors: Hong
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004804:Eosinophils / Q000166:cytology; D005076:Exanthema / Q000139:chemically induced / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D013624:Taiwan / Q000453:epidemiology
chemical_list: D002097:C-Reactive Protein