title: Stereoselective direct copper-catalyzed alkenylation of oxazoles with bromoalkenes.
abstract: A copper-catalyzed direct alkenylation of oxazoles with bromoalkenes has been developed. The method is both regio- and stereoselective and tolerates a variety of functional groups. A wide range of 2-E-vinyl-substituted oxazoles were obtained in high yields including the highly fluorescent alkaloid annuloline.
authors: Univ Paris-Sud, Orsay F-91405, France.
authors: François
authors: F
authors: Besselièvre
authors: Sandrine
authors: S
authors: Piguel
authors: Florence
authors: F
authors: Mahuteau-Betzer
authors: David S
authors: DS
authors: Grierson
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry*; D013237:Stereoisomerism; D020058:Styrene / Q000737:chemistry; D013379:Substrate Specificity
chemical_list: D000475:Alkenes; D001965:Bromides; D010080:Oxazoles; D020058:Styrene; D003300:Copper