title: White matter lesions as a feature of cognitive impairment, low vitality and other symptoms of geriatric syndrome in the elderly.
abstract: OBJECTIVE
  White matter lesions (WML) are common findings on magnetic resonance imaging (MRI) in elderly persons. In this study, we analyzed the relation of WML with global cognitive function, depression, vitality/volition, and 19 symptoms of geriatric syndrome in Japanese elderly patients who attended three university geriatric outpatient clinics.
  
  
  METHODS
  Two hundred and eighty-six subjects (103 men and 183 women; mean +/- standard deviation age, 74.5 +/- 7.8 years) were included in this study. MRI scans were performed for the diagnosis of WML, and the severity of periventricular and deep white matter hyperintensities (PVH and DWMH) was rated semiquantitatively. Concurrently, all subjects underwent tests of cognitive function, depressive state and vitality, and were examined for 19 symptoms of geriatric syndrome.
  
  
  RESULTS
  The study subjects showed cognitive decline, depression and low vitality, all to a mild extent. Univariate linear regression analysis showed a negative correlation between the severity of WML and cognitive function or vitality. Multiple logistic analysis revealed that the severity of WML was a significant determinant of cognitive impairment and low vitality, after adjustment for confounding factors such as age, sex and concomitant diseases. PVH and/or DWMH score was significantly greater in subjects who exhibited 13 out of 19 symptoms of geriatric syndrome. Logistic regression analysis indicated that WML were associated with psychological disorders, gait disturbance, urinary problems and parkinsonism.
  
  
  CONCLUSIONS
  WML were associated with various symptoms of functional decline in older persons. Evaluating WML in relation to functional decline would be important for preventing disability in elderly people.
authors: Department of Geriatric Medicine, Kyorin University School of Medicine, Mitaka, Japan.
authors: Kazuki
authors: K
authors: Sonohara
authors: Koichi
authors: K
authors: Kozaki
authors: Masahiro
authors: M
authors: Akishita
authors: Kumiko
authors: K
authors: Nagai
authors: Hiroshi
authors: H
authors: Hasegawa
authors: Masafumi
authors: M
authors: Kuzuya
authors: Koutaro
authors: K
authors: Yokote
authors: Kenji
authors: K
authors: Toba
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology* / Q000523:psychology; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000150:complications* / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology*; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003863:Depression; D005260:Female; D006304:Health Status; D006801:Humans; D007564:Japan; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009483:Neuropsychological Tests; D013577:Syndrome