title: Current status of thrombolytics-the need for better, especially safer, agents.
abstract: Clot dissolution using enzymes from the human fibrinolytic system has long been a goal of physicians and scientists. While recent focus has been on activators of the fibrinolytic system, new data support the use of plasmin itself. This supplement reviews the role of plasmin in fibrinolysis and locally administered plasmin as a safe and effective therapeutic.
authors: BloodCenter of Wisconsin, Milwaukee, WI, USA. gcwhite@bcw.edu
authors: Gilbert C
authors: GC
authors: White
mesh_terms: D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D013927:Thrombosis / Q000188:drug therapy*
chemical_list: D005343:Fibrinolytic Agents