title: Tetrasomy 8 in a patient with acute monoblastic leukemia.
abstract: Trisomy 8 is one of the most frequent numerical chromosomal abnormalities observed in hematological malignancies, whereas tetrasomy 8 is a clonal aberration seen mainly in myeloid disorders such as acute myelod leukemia (AML) and myelodysplastic syndromes. In contrast to trisomy 8, tetrasomy 8 is a rare chromosomal aberration, in that only 17 reported AML cases with isolated tetrasomy 8 have been documented. Interestingly, the majority of reported cases were associated with monocytic-lineage leukemias. According to recent reports, tetrasomy 8 is regarded as a poor prognostic factor, and most patients having this abnormality relapsed and died within 1 yr. Here, we report a patient with acute monoblastic leukemia having tetrasomy 8 and a very aggressive disease course.
authors: Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors: Juwon
authors: J
authors: Kim
authors: Tae Sung
authors: TS
authors: Park
authors: Jaewoo
authors: J
authors: Song
authors: Kyung-A
authors: KA
authors: Lee
authors: Sang-Guk
authors: SG
authors: Lee
authors: June-Won
authors: JW
authors: Cheong
authors: Jong Rak
authors: JR
authors: Choi
mesh_terms: D000782:Aneuploidy; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged