title: The evolution and functional diversification of animal microRNA genes.
abstract: microRNAs (miRNAs) are an abundant class of approximately 22 nucleotide (nt) regulatory RNAs that are pervasive in higher eukaryotic genomes. In order to fully understand their prominence in genomes, it is necessary to elucidate the molecular mechanisms that can diversify miRNA activities. In this review, we describe some of the many strategies that allow novel miRNA functions to emerge, with particular emphasis on how miRNA genes evolve in animals. These mechanisms include changes in their sequence, processing, or expression pattern; acquisition of miRNA* functionality or antisense processing; and de novo gene birth. The facility and versatility of miRNAs to evolve and change likely underlies how they have become dominant constituents of higher genomes.
authors: Department of Developmental Biology, Sloan-Kettering Institute, 521 Rockefeller Research Laboratories, New York, NY 10065, USA.
authors: Na
authors: N
authors: Liu
authors: Katsutomo
authors: K
authors: Okamura
authors: David M
authors: DM
authors: Tyler
authors: Michael D
authors: MD
authors: Phillips
authors: Wei-Jen
authors: WJ
authors: Chung
authors: Eric C
authors: EC
authors: Lai
mesh_terms: D000818:Animals; D001483:Base Sequence; D004331:Drosophila melanogaster / Q000235:genetics; D019143:Evolution, Molecular; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D034622:RNA Interference; D012323:RNA Processing, Post-Transcriptional; D022661:RNA, Untranslated / Q000235:genetics
chemical_list: D035683:MicroRNAs; D022661:RNA, Untranslated