Regulation of CD8(+) T cell functions by RARgamma.
Retinoic acid plays a key role in the development and function of the immune system; however, the contribution of each of the three retinoic acid receptors (RARs) to the T cell immune response is not yet well understood. Of these receptors, both RARalpha and RARgamma are expressed in T lymphocytes. While possible functional redundancy thus complicates understanding of the role of each receptor in T cells, emerging data suggest that RARalpha and RARgamma function differently in thymocyte development and that RARgamma is required for both primary and secondary CD8(+) T cell immune responses.
Gordy
Claire
C
Department of Immunology, Duke University Medical Center, Durham, NC 27710, United States.
Dzhagalov
Ivan
I
He
You-Wen
YW
D000818:Animals; D000970:Antineoplastic Agents / Q000276:immunology / Q000378:metabolism; D017209:Apoptosis / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000276:immunology / Q000378:metabolism; D006801:Humans; D018168:Receptors, Retinoic Acid / Q000276:immunology / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D014212:Tretinoin / Q000276:immunology* / Q000378:metabolism; D000097768:Retinoic Acid Receptor gamma
D000970:Antineoplastic Agents; D018168:Receptors, Retinoic Acid; D014212:Tretinoin; D000097768:Retinoic Acid Receptor gamma