title: Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates.
abstract: Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously implicated in OA production. Analysis of 16S rRNA libraries reveals that Roseobacter are the most abundant bacteria associated with OA producing dinoflagellates of the genus Prorocentrum and are not found in association with non-toxic dinoflagellates. While some polyketide synthase (PKS) genes form a highly supported Prorocentrum clade, most appear to be bacterial, but unrelated to Roseobacter or Alpha-Proteobacterial PKSs or those derived from other Alveolates Karenia brevis or Crytosporidium parvum.
authors: Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA. rperez@med.miami.edu
authors: Roberto
authors: R
authors: Perez
authors: Li
authors: L
authors: Liu
authors: Jose
authors: J
authors: Lopez
authors: Tianying
authors: T
authors: An
authors: Kathleen S
authors: KS
authors: Rein
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004141:Dinoflagellida / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D019319:Okadaic Acid / Q000378:metabolism*; D010802:Phylogeny; D048630:Polyketide Synthases / Q000235:genetics*; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D041904:Roseobacter / Q000378:metabolism; D016415:Sequence Alignment
chemical_list: D012336:RNA, Ribosomal, 16S; D019319:Okadaic Acid; D048630:Polyketide Synthases