[Type I and II collagens and mast cells expression in the skin lesions from the patients with localized scleroderma].
Morphea en plaques (MP) and atrophoderma Pasini-Pierini (APP) are by most researchers regarded as specific types of localized scleroderma (LS), but their clinical picture is completely different. Fibrosing process is very complicated, and is connected with presence of collagen (I and III type) and extracellulare matrix deposits in the dermis. Probably mast cells also play an important role in this process. The aim of the study is estimation of the expression of type I and III collagens and number of mast cells in lesions from patients with APP and MP. 36 patients were enrolled to the study. Immunohistochemical tests were performed to observe presence of type I and III collagens and presence of mast cells in the dermis. We observed that patients with APP showed lower expression of the I and III type collagens in the dermis than patients with MP. Expression of I type collagen decreases with time only among patients with MP. There was no similar relation for type III collagen. High and very high expression of type I and III collagen was observed more frequently in the active phase of the disease in patients with MP. Number of mast cells was higher in patients with APP than in MP. The number of the mast cells increases with time of disease in patients with MP, and there is correlation between high number of mast cells and low expression of the I and III collagens in the patients with MP.
Wielowieyska-Szybińska
Dorota
D
Katedra i Klinika Dermatologii, Collegium Medicum, Uniwersytet Jagielloński, Kraków.
Wojas-Pelc
Anna
A
Dyduch
Grzegorz
G
Zawisz
Artur
A
D000328:Adult; D001706:Biopsy; D024042:Collagen Type I / Q000378:metabolism*; D024043:Collagen Type II / Q000378:metabolism*; D020405:Dermis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008407:Mast Cells / Q000378:metabolism* / Q000473:pathology; D012594:Scleroderma, Localized / Q000145:classification* / Q000378:metabolism* / Q000473:pathology
D024042:Collagen Type I; D024043:Collagen Type II