title: Effects of vanadium-containing compounds on membrane lipids and on microdomains used in receptor-mediated signaling.
abstract: There is increasing evidence for the involvement of plasma membrane microdomains in insulin receptor function. Moreover, disruption of these structures, which are typically enriched in sphingomyelin and cholesterol, results in insulin resistance. Treatment strategies for insulin resistance include the use of vanadium (V) compounds which have been shown in animal models to enhance insulin responsiveness. One possible mechanism for insulin-enhancing effects might involve direct effects of V compounds on membrane lipid organization. These changes in lipid organization promote the partitioning of insulin receptors and other receptors into membrane microdomains where receptors are optimally functional. To explore this possibility, we have used several strategies involving V complexes such as [VO(2)(dipic)](-) (pyridin-2,6-dicarboxylatodioxovanadium(V)), decavanadate (V(10)O(28)(6-), V(10)), BMOV (bis(maltolato)oxovanadium(IV)), and [VO(saltris)](2) (2-salicylideniminato-2-(hydroxymethyl)-1,3-dihydroxypropane-oxovanadium(V)). Our strategies include an evaluation of interactions between V-containing compounds and model lipid systems, an evaluation of the effects of V compounds on lipid fluidity in erythrocyte membranes, and studies of the effects of V-containing compounds on signaling events initiated by receptors known to use membrane microdomains as signaling platforms.
authors: Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1872, USA.
authors: Deborah A
authors: DA
authors: Roess
authors: Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1872, USA.
authors: Steven M L
authors: SML
authors: Smith
authors: Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1872, USA.
authors: Peter
authors: P
authors: Winter
authors: Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1872, USA.
authors: Jun
authors: J
authors: Zhou
authors: Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1872, USA.
authors: Ping
authors: P
authors: Dou
authors: Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA.
authors: Bharat
authors: B
authors: Baruah
authors: Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA.
authors: Alejandro M
authors: AM
authors: Trujillo
authors: Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA.
authors: Nancy E
authors: NE
authors: Levinger
authors: Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, P. R. China.
authors: Xioda
authors: X
authors: Yang
authors: Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA.
authors: B George
authors: BG
authors: Barisas
authors: Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA.
authors: Debbie C
authors: DC
authors: Crans
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D051275:Glucose Transporter Type 4 / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism*; D021962:Membrane Microdomains / Q000187:drug effects* / Q000378:metabolism*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000494:pharmacology*; D051381:Rats; D011972:Receptor, Insulin / Q000378:metabolism*; D012015:Reference Standards; D015398:Signal Transduction / Q000187:drug effects*; D014639:Vanadium / Q000494:pharmacology*
chemical_list: D051275:Glucose Transporter Type 4; D007328:Insulin; D008024:Ligands; D008563:Membrane Lipids; D009942:Organometallic Compounds; C495694:Slc2a4 protein, rat; D014639:Vanadium; D011972:Receptor, Insulin; D002118:Calcium