title: Reproductive, menstrual, and other hormone-related factors and risk of renal cell cancer.
abstract: A role of hormone-related factors in renal cell cancer (RCC) etiology has been hypothesized, but the epidemiological evidence is inconsistent. The present study aimed at evaluating the effect of reproductive, menstrual and other gender-specific variables on RCC risk among women. This study is part of a larger hospital-based, case-control study on RCC risk, conducted in northern, central and southern Italy. Cases were 273 women, below age 80, with histologically confirmed, incident RCC. Controls were 546 women hospitalized for acute, nonneoplastic conditions, frequency-matched to cases by age and center. Odds ratios (OR) and 95% confidence intervals (CI) were computed using multiple logistic regression models. RCC risk was inversely related to age at first birth (OR = 0.7, 95% CI 0.5-1.0, for >/= 25 years vs. <25 years). Hysterectomy was found to double RCC risk (OR = 2.3, 95% CI 1.3-4.2). A negative association of borderline-statistical significance emerged for age at menarche, whereas, no associations were found between RCC risk and parity, menopausal status, age at menopause and use of hormone replacement therapy or oral contraceptives. Our findings give support to a role of hysterectomy in increasing RCC risk without corroborating, however, a major role of female hormone-related factors.
authors: SOC Epidemiologia e Biostatistica, IRCCS "Centro di Riferimento Oncologico", Aviano (PN), Italy. epidemiology@cro.it
authors: Antonella
authors: A
authors: Zucchetto
authors: Renato
authors: R
authors: Talamini
authors: Luigino
authors: L
authors: Dal Maso
authors: Eva
authors: E
authors: Negri
authors: Jerry
authors: J
authors: Polesel
authors: Valerio
authors: V
authors: Ramazzotti
authors: Maurizio
authors: M
authors: Montella
authors: Vincenzo
authors: V
authors: Canzonieri
authors: Diego
authors: D
authors: Serraino
authors: Carlo
authors: C
authors: La Vecchia
authors: Silvia
authors: S
authors: Franceschi
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000209:etiology*; D016022:Case-Control Studies; D003276:Contraceptives, Oral / Q000009:adverse effects; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007680:Kidney Neoplasms / Q000209:etiology*; D016015:Logistic Models; D008598:Menstruation; D008875:Middle Aged; D010298:Parity; D011247:Pregnancy; D012098:Reproduction; D012306:Risk
chemical_list: D003276:Contraceptives, Oral