[Correlation of chemokine CCL-2/MCP-1 level in the plasma with aGVHD and idiophathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation].
The aim of this study was to investigate the relationship between the plasma levels of chemokine CCL-2/MCP-1 and acute graft-versus-host disease (aGVHD) and/or idiopathic pneumonia syndrome (IPS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). ELISA assays were used to detect the plasma level of CCL-2/MCP-1 of 22 patients who received allo-HSCT, including 14 patients without or with grade I, 8 patients with grade II - IV aGVHD, respectively. 8 out of 22 patients were also diagnosed with IPS clinically. The dynamic changes of the plasma levels of CCL-2/MCP-1 chemokine and its correlation with aGVHD and/or IPS were analysized retrospectively. The results showed that the plasma levels of CCL-2/MCP-1 in the patients with moderate and serious aGVHD (grade II - IV) significantly increased, as compared with that prior to allo-HSCT (p < 0.05). The plasma levels of CCL-2/MCP-1 in the patients with aGVHD and/or IPS were higher significantly than those without any of these complications (p = 0.001). The retrospective analysis indicated that the plasma levels of CCL-2/MCP-1 in the patients with IPS significantly increased (p = 0.006). It is concluded that plasma level of CCL-2/MCP-1 correlates with aGVHD and/or IPS, and plays a role in the pathogenesis of these complications.
Ouyang
Min
M
Department of Hematology, Peking University First Hospital, Beijing 100034, China.
Ren
Han-Yun
HY
Yin
Yue
Y
Qiu
Zhi-Xiang
ZX
Cen
Xi-Nan
XN
Wang
Li-Hong
LH
Ou
Jin-Ping
JP
Wang
Wen-Sheng
WS
Wang
Mang-Ju
MJ
Li
Yuan
Y
Shi
Yong-Jin
YJ
D000293:Adolescent; D000328:Adult; D018932:Chemokine CCL2 / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000097:blood* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D055815:Young Adult
C111835:CCL2 protein, human; D018932:Chemokine CCL2