title: Light-induced biocidal action of conjugated polyelectrolytes supported on colloids.
abstract: A series of water soluble, cationic conjugated polyelectrolytes (CPEs) with backbones based on a poly(phenylene ethynylene) repeat unit structure and tetraakylammonium side groups exhibit a profound light-induced biocidal effect. The present study examines the biocidal activity of the CPEs, correlating this activity with the photophysical properties of the polymers. The photophysical properties of the CPEs are studied in solution, and the results demonstrate that direct excitation produces a triplet excited-state in moderate yield, and the triplet is shown to be effective at sensitizing the production of singlet oxygen. Using the polymers in a format where they are physisorbed or covalently grafted to the surface of colloidal silica particles (5 and 30 microm diameter), we demonstrate that they exhibit light-activated biocidal activity, effectively killing Cobetia marina and Pseudomonas aeruginosa. The light-induced biocidal activity is also correlated with a requirement for oxygen suggesting that interfacial generation of singlet oxygen is the crucial step in the light-induced biocidal activity.
authors: Department of Chemical and Nuclear Engineering, University of New Mexico, Albuquerque, New Mexico 87131-1341, USA.
authors: Sireesha
authors: S
authors: Chemburu
authors: Thomas S
authors: TS
authors: Corbitt
authors: Linnea K
authors: LK
authors: Ista
authors: Eunkyung
authors: E
authors: Ji
authors: Julia
authors: J
authors: Fulghum
authors: Gabriel P
authors: GP
authors: Lopez
authors: Katsu
authors: K
authors: Ogawa
authors: Kirk S
authors: KS
authors: Schanze
authors: David G
authors: DG
authors: Whitten
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D003102:Colloids; D004573:Electrolytes; D008027:Light; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D044130:Oceanospirillaceae / Q000187:drug effects; D010777:Photochemistry; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D026082:Singlet Oxygen / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D003102:Colloids; D004573:Electrolytes; D011108:Polymers; D026082:Singlet Oxygen