title: Long-term effects of overfeeding during lactation on insulin secretion--the role of GLUT-2.
abstract: Overnutrition during critical developmental periods is believed to be a risk factor for the emergence of metabolic disorders in adulthood. The present study investigated the effects of pups overfeeding during lactation on offspring's insulin secretion. To study the consequences of overnutrition early in life in rats, litter size reduction has been shown to be an appropriate experimental model. To induce early postnatal overnutrition, litter size was reduced to three pups per litter at the third day following birth [overfed group (OG)]. In the control group (CG), the litter size was adjusted to 10 pups per litter. Metabolic parameters and glucose-stimulated insulin secretion were assessed. OG pups ingested more milk at 10 and 21 days and had an augmented food intake at 1 year compared to the CG. Consistently, body weight, body fat, and fasting plasma levels of insulin were higher in 1-year-old OG rats. In addition, OG rats exhibited enhanced insulin secretion, accompanied by elevated content of GLUT-2 in pancreatic islets compared to CG. These findings indicate that early postnatal overnutrition during a critical developmental period in life may program permanent alterations in glucose-stimulated insulin secretion.
authors: Departament of Physiological Sciences, State University of Rio de Janeiro, 20550-030 Rio de Janeiro, Brazil.
authors: Alessandra Cordeiro de Souza Rodrigues
authors: AC
authors: Cunha
authors: Renata Oliveira
authors: RO
authors: Pereira
authors: Mario José dos Santos
authors: MJ
authors: Pereira
authors: Vivian de Melo
authors: Vde M
authors: Soares
authors: Mariana Renovato
authors: MR
authors: Martins
authors: Michelle Teixeira
authors: MT
authors: Teixeira
authors: Erica Patrícia Garcia
authors: EP
authors: Souza
authors: Anibal Sanchez
authors: AS
authors: Moura
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D001823:Body Composition; D001835:Body Weight; D004435:Eating / Q000502:physiology; D005260:Female; D051273:Glucose Transporter Type 2 / Q000378:metabolism*; D006963:Hyperphagia / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism; D007774:Lactation / Q000502:physiology*; D008098:Litter Size; D051057:Proto-Oncogene Proteins c-akt; D051381:Rats; D017208:Rats, Wistar; D013995:Time
chemical_list: D051273:Glucose Transporter Type 2; D007328:Insulin; C495683:Slc2a2 protein, rat; D051057:Proto-Oncogene Proteins c-akt