An economic evaluation of vasoactive agents used to treat acute bleeding oesophageal varices in Belgium.
OBJECTIVE
Increasingly, cost influences all areas of healthcare, including the management of life threatening events, such as bleeding oesophageal varices (BOV). In light of the need to control costs, an economic evaluation of vasoactive agents used to treat cirrhotic patients with BOV within the emergency setting in Belgium has been assessed.


METHODS
A previously reported economic evaluation of vasoactive agents used to treat BOV was identified and adapted to the Belgium hospital setting. The economic evaluation was based on double-blind randomised controlled trials of vasoactive agents previously reported as Cochrane meta-analyses. Belgian cost data was obtained from local published sources and hospital databases. We assessed average disaggregated and aggregated treatment costs, average and incremental cost per quality adjusted life years (QALYs) and life-years gained (LYG).


RESULTS
Total treatment costs at 1 year were: terlipressin Euro 2,734; somatostatine Euro 2,972; octreotide Euro 2,801; and placebo Euro 2,874. The average costs per QALY were: terlipressin Euro 4,672; somatostatine Euro 5,878; octreotide Euro 5,540; and placebo Euro 5,687. In the cost per LYG analysis terlipressin achieved the lowest cost per life-year. Results from the incremental cost per QALY and LYG analysis indicated that terlipressin was the most cost-effective agent.


CONCLUSIONS
One year simulations indicate somatostatine is the most expensive treatment option and terlipressin the least costly. Amongst the vasoactive products, the incremental analysis indicated terlipressin was dominant when compared with octreotide and somatostatine because of improved survival and cost-saving potential that is likely attributed to avoiding additional and more costly interventions.
Connolly
Mark
M
Ferring International Center, St Prex, Switzerland. mark@gmasoln.com
Bhatt
Aomesh
A
Wechowski
Jaro
J
Colle
Isabelle
I
D001530:Belgium / Q000453:epidemiology; D003365:Costs and Cost Analysis; D004932:Esophageal and Gastric Varices / Q000188:drug therapy* / Q000191:economics / Q000453:epidemiology; D005500:Follow-Up Studies; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000191:economics / Q000453:epidemiology; D017048:Health Care Costs / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D015201:Meta-Analysis as Topic; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000191:economics* / Q000627:therapeutic use
D014662:Vasoconstrictor Agents