title: IgA deposits along glomerular basement membranes in rapidly progressive glomerulonephritis.
abstract: This case presents a rare type of crescentic glomerulonephritis characterized as IgA deposits predominantly along the glomerular basement membranes (GBM). The patient clinically manifested with rapidly progressive glomerulonephritis (RPGN) without pulmonary hemorrhage or vasculitis-related systematic symptoms. No positive results were found on antinuclear antibody (ANA), antineutrophil cytoplasmic antibody (ANCA), or anti-GBM antibody detection. Therapy with pulse methylprednisolone and intravenous cyclophosphamide was less effective. This case does not belong to the present three categories of crescentic glomerulonephritis based on the clinical characteristics, serum test, immunofluorescence, and electron microscopic findings.
authors: Department of Nephrology, Kidney Institute and Key Lab of PLA, PLA General Hospital, Beijing, People's Republic of China.
authors: Guangyan
authors: G
authors: Cai
authors: Pu
authors: P
authors: Chen
authors: Di
authors: D
authors: Wu
authors: Suozhu
authors: S
authors: Shi
authors: Zhong
authors: Z
authors: Yin
authors: Xueguang
authors: X
authors: Zhang
authors: Ribao
authors: R
authors: Wei
authors: Xiangmei
authors: X
authors: Chen
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D018450:Disease Progression; D019085:Fluorescent Antibody Technique, Direct; D050533:Glomerular Basement Membrane / Q000276:immunology*; D005921:Glomerulonephritis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D007070:Immunoglobulin A; D016756:Immunoglobulins, Intravenous; D011239:Prednisolone; D009173:Mycophenolic Acid; D008775:Methylprednisolone