Circulating E-selectin and tumor necrosis factor-alpha in extraarticular involvement and joint disease activity in rheumatoid arthritis.
In this cross-sectional study, we assessed the relationship between circulating TNF-alpha and E-selectin (sE-selectin) with extraarticular involvement and severity of joint disease in RA. We compared 56 patients who had RA and extraarticular involvement (ExRA) with a group of 84 patients with only articular involvement (non-ExRA). ExRA had higher circulating TNF-alpha than non-ExRA (32 +/- 9 vs. 28 +/- 6 pg/mL, P = 0.002). sE-selectin levels did not differ between both groups. sE-selectin correlated with tender joint count (rho = 0.19, P = 0.03), morning stiffness (rho = 0.19, P = 0.03), severity of pain (rho = 0.21, P = 0.02), disease activity (assessed by the patient) (rho = 0.21, P = 0.02), HAQ-DI (rho = 0.29, P = 0.004), and rheumatoid factor titers (rho = 0.31, P = <0.001). Circulating TNF-alpha had no correlation with sE-selectin or disease activity. We concluded that sE-selectin correlated with severity of joint disease, further follow-up studies should evaluate if sE-selectin is useful as prognosis marker for progression of articular damage.
Corona-Sanchez
Esther G
EG
Section of Musculoskeletal Diseases and Autoimmunity, Clinical Epidemiology Research Unit, Instituto Mexicano del Seguro Social (IMSS), Hospital de Especialidades Centro Médico Nacional de Occidente, Guadalajara, Mexico.
Gonzalez-Lopez
Laura
L
Muñoz-Valle
Jose F
JF
Vazquez-Del Mercado
Monica
M
Lopez-Olivo
Maria A
MA
Aguilar-Chavez
Erika A
EA
Salazar-Paramo
Mario
M
Loaiza-Cardenas
Carlos
C
Oregon-Romero
Edith
E
Navarro-Hernandez
Rosa E
RE
Gamez-Nava
Jorge I
JI
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000150:complications; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D015415:Biomarkers; D019040:E-Selectin; D014409:Tumor Necrosis Factor-alpha