Is there a relationship between glomerular filtration rate and detrusor overactivity in women?
OBJECTIVE
The relationship of detrusor overactivity (DO) to neuromuscular causes is well established, but a connection to kidney function has not yet been studied. We sought to evaluate whether patients with DO have differences in estimated glomerular filtration rate (eGFR).


METHODS
After Institutional Review Board approval, we collected data from all patients who underwent urodynamic testing in our office from September 1, 2006 to February 28, 2007 and calculated eGFR using the equation derived from the Modification of Diet in Renal Disease (MDRD) study.


RESULTS
Data were collected on 359 patients, who had a mean eGFR for all patients of 82.99 ml/min/1.73 m(2) (+/-22.2). The patients were divided into groups by the presence or absence of DO on filling cystometry. There was no significant difference in eGFR between the patients with and without DO (80.9 ml/min/1.73 m(2) vs. 84.4, P = 0.290).


CONCLUSIONS
Kidney function does not differ between patients with or without DO.
Schimpf
Megan O
MO
Department of Obstetrics and Gynecology, Division of Urogynecology, Hartford Hospital, Hartford, Connecticut, USA. drmeganschimpf@gmail.com
O'Sullivan
David M
DM
Steinberg
Adam C
AC
Lasala
Christine A
CA
Tulikangas
Paul K
PK
D015992:Body Mass Index; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007677:Kidney Function Tests; D008875:Middle Aged; D001743:Urinary Bladder / Q000503:physiopathology; D053201:Urinary Bladder, Overactive / Q000503:physiopathology*; D053202:Urinary Incontinence, Urge / Q000503:physiopathology; D014563:Urodynamics / Q000502:physiology
D003404:Creatinine