title: Structural classification of toxic amyloid oligomers.
abstract: Amyloid oligomers are believed to play important causal roles in many types of amyloid-related degenerative diseases. Many different laboratories have reported amyloid oligomers that differ in size, morphology, toxicity, and method of preparation or purification, raising the question of the structural relationships among these oligomer preparations. The structural plasticity that has been reported to occur in amyloids formed from the same protein sequence indicates that it is quite possible that different oligomer preparations may represent distinct structural variants. In view of the difficulty in determining the precise structure of amyloids, conformation- and epitope-specific antibodies may provide a facile means of classifying amyloid oligomer structures. Conformation-dependent antibodies that recognize generic epitopes that are specifically associated with distinct aggregation states of many different amyloid-forming sequences indicate that there are at least two fundamentally distinct types of amyloid oligomers: fibrillar and prefibrillar oligomers. Classification of amyloid oligomers according to their underlying structures may be a more useful and rational approach than relying on differences in size and morphology.
authors: Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA. cglabe@uci.edu
authors: Charles G
authors: CG
authors: Glabe
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000145:classification / Q000633:toxicity; D000818:Animals; D000906:Antibodies / Q000737:chemistry; D001921:Brain / Q000196:embryology; D000939:Epitopes / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D008968:Molecular Conformation; D011487:Protein Conformation; D011489:Protein Denaturation; D017510:Protein Folding
chemical_list: D016229:Amyloid beta-Peptides; D000906:Antibodies; D000939:Epitopes