title: [A case of miliary tuberculosis with interstitial nephritis due to re-administration of rifampicin treated successfully with steroid].
abstract: A 26-year-old man was admitted to a hospital complaing of continuous high fever and abdominal swelling. As his sputum and ascites culture was positive for acid-fast bacilli and PCR-TB, he was diagnosed as miliary tuberculosis, tuberculous with pleuritis and peritonitis, and transferrd to our hospital. After initiation of treatment with isoniazid, rifampicin (RFP), ethambutol, and pyrazinamide, RFP was suspended because of direct-reacting hyperbilirubinemia. As the liver function recovered after discontinuation of RFP, low dose of RFP was re-administrated and renal dysfunction was observed. The renal dysfunction continued after discontinuation of suspicious drugs including RFP. As renal biopsy revealed interstitial nephritis, prednisolon 20 mg/day was started and renal function recovered quickly. From the clinical course and examination, we considered interstitial nephritis was due to re-administration of RFP and steroid therapy was effective.
authors: Department of Thoracic Disease, National Hospital Organization Chiba-East National Hospital, Chuo-ku, Chiba-shi, Chiba, Japan. t-kawa@cehpnet.com
authors: Takeshi
authors: T
authors: Kawasaki
authors: Yuka
authors: Y
authors: Sasaki
authors: Aya
authors: A
authors: Dan
authors: Rei
authors: R
authors: Bekku
authors: Tomohiro
authors: T
authors: Hashimoto
authors: Masakatsu
authors: M
authors: Tamaki
authors: Fumio
authors: F
authors: Yamagishi
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D011239:Prednisolone / Q000627:therapeutic use*; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects*; D014391:Tuberculosis, Miliary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D005938:Glucocorticoids; D011239:Prednisolone; D012293:Rifampin