RBM4: a multifunctional RNA-binding protein.
RBM4, also known as Lark, was described initially as having a role in circadian rhythm control in Drosophila. In the last 5 years data have emerged from studies of mammalian cells. It is now clear that RBM4 is an RNA-binding protein involved in diverse cellular processes that include alternative splicing of pre-mRNA, translation, and RNA silencing. Its structure, similar to other RNA-binding proteins, contains two RNA recognition motifs and a CCHC-type zinc finger. Here we review current information about the function of RBM4 and its localization within the cell. We then speculate about its possible relationship to disease.
Markus
M Andrea
MA
Basic & Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, Building F13, The University of Sydney, Sydney, NSW 2006, Australia.
Morris
Brian J
BJ
D000818:Animals; D006801:Humans; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000502:physiology*
C473692:RBM4 protein, human; D016601:RNA-Binding Proteins