Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls.
Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.
Fridberg
Marie
M
Department of Tumor Biology, Lund University, Malmö University Hospital, Malmö, Sweden.
Kjellström
Sofia
S
Anagnostaki
Lola
L
Skogvall
Ingela
I
Mustelin
Tomas
T
Wiebe
Thomas
T
Persson
Jenny L
JL
Dictor
Michael
M
Wingren
Anette Gjörloff
AG
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008297:Male; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000096:biosynthesis*; D054558:Protein Tyrosine Phosphatases, Non-Receptor / Q000378:metabolism*
C502159:PTPN7 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D054558:Protein Tyrosine Phosphatases, Non-Receptor; D051059:PTEN Phosphohydrolase