title: Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls.
abstract: Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.
authors: Department of Tumor Biology, Lund University, Malmö University Hospital, Malmö, Sweden.
authors: Marie
authors: M
authors: Fridberg
authors: Sofia
authors: S
authors: Kjellström
authors: Lola
authors: L
authors: Anagnostaki
authors: Ingela
authors: I
authors: Skogvall
authors: Tomas
authors: T
authors: Mustelin
authors: Thomas
authors: T
authors: Wiebe
authors: Jenny L
authors: JL
authors: Persson
authors: Michael
authors: M
authors: Dictor
authors: Anette Gjörloff
authors: AG
authors: Wingren
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008297:Male; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000096:biosynthesis*; D054558:Protein Tyrosine Phosphatases, Non-Receptor / Q000378:metabolism*
chemical_list: C502159:PTPN7 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D054558:Protein Tyrosine Phosphatases, Non-Receptor; D051059:PTEN Phosphohydrolase