Anaemia and marrow fibrosis in patients with primary hyperparathyroidism before and after curative parathyroidectomy.
OBJECTIVE
To determine the relationship between anaemia and myelofibrosis in patients with symptomatic primary hyperparathyroidism (PHPT) and to assess the effect of curative parathyroidectomy on anaemia and marrow fibrosis.


METHODS
In this prospective follow-up study of 28 consecutive patients with symptomatic PHPT from January 2005 to June 2006, 15 patients were diagnosed with anaemia (haemoglobin < 130 g/l in males and < 120 g/l in females), eight (53%) of whom were finally recruited for the study. Complete blood cell count, serum calcium, phosphorus, alkaline phosphatase, intact PTH and 25-hydroxyvitamin D and bone marrow examination were performed both before and after parathyroidectomy in all (n = 8) patients, but bone marrow examination after surgery was performed only in those who had marrow fibrosis at baseline (n = 6).


RESULTS
Anaemia was observed in 15 (53.3%) of the 28 patients with symptomatic PHPT. Normocytic normochromic anaemia that is characteristic of PHPT was found in 14 (50%) patients. Eight of the 15 patients with anaemia had a bone marrow examination and marrow fibrosis was observed in six (75%). Both anaemia and marrow fibrosis improved after successful parathyroidectomy, but improvement in anaemia was significant (P = 0.02) only in those with marrow fibrosis at baseline. Marrow fibrosis did not correlate with duration of the disease (P = 0.17), degree of hypercalcaemia (P = 0.53) or serum levels of intact PTH (P = 0.60).


CONCLUSIONS
Anaemia is common in patients with symptomatic PHPT, and was associated with marrow fibrosis in the majority of the patients who underwent bone biopsy. Both anaemia and marrow fibrosis improved after curative parathyroidectomy, but improvement in anaemia was noticeable only in those who had marrow fibrosis at presentation.
Bhadada
Sanjay K
SK
Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Bhansali
Anil
A
Ahluwalia
Jasmina
J
Chanukya
G V
GV
Behera
Arunanshu
A
Dutta
Pinaki
P
D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000740:Anemia / Q000097:blood / Q000601:surgery*; D001706:Biopsy; D001842:Bone and Bones / Q000473:pathology; D002118:Calcium / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D055728:Primary Myelofibrosis / Q000097:blood / Q000473:pathology / Q000601:surgery*; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D010281:Parathyroid Hormone; D000469:Alkaline Phosphatase; D002118:Calcium