Efficient regioselective chemical modifications of maltotriose: an easy access to oligosaccharidic scaffold.
Regioselective chlorination of fully unprotected maltotriose has given in high yield 1(I),2(I-III),3(I-III),4(III)-octa-O-acetyl-6(I-III)-trichloro-6(I-III)-trideoxymaltotriose. Moreover, regioselective ditritylation of methyl β-maltotrioside has provided the two regioselectively C(6)-disubstituted trisaccharides. Selective deprotection of these new compounds gives the corresponding diol and halogenated analogues, respectively, in good yield. All compounds have been completely characterized and the substitution pattern in the oligosaccharidic sequence has been elucidated. A new family of amphiphilic carbohydrates, namely the 6-deoxy-6-alkylthiomaltotriose derivatives, bearing either two or three thioalkyl hydrophobic chains, respectively, has been synthesized. Critical micellar concentration (CMC) values as well as the antimicrobial properties have been evaluated for amphiphilic compounds.
Thiebault
Nicolas
N
Laboratoire des Glucides, CNRS-UMR 6219, Institut de Chimie de Picardie, Université de Picardie Jules Verne, 33 rue St Leu, 80039 Amiens, France.
Lesur
David
D
Godé
Paul
P
Moreau
Vincent
V
Djedaïni-Pilard
Florence
F
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D014312:Trisaccharides / Q000737:chemistry*
D009844:Oligosaccharides; D014312:Trisaccharides