Solitary pleural plasmacytomas manifested as a massive pleural effusion without evidence of monoclonal gammopathy.
The majority of extramedullary plasmacytomas involve the upper respiratory tract but only a few are associated with serum monoclonal gammopathy. Most extramedullary plasmacytomas respond to local radiotherapy and have a better prognosis than multiple myeloma. Solitary plasmacytomas, involving the pleura, are very rare. This case report describes a patient with a solitary extramedullary plasmacytoma involving the pleura, and no evidence of serum, urine or pleural fluid paraproteins. Diagnosis was made by strongly positive immunohistochemical stains with CD38, CD138 and MUM-1 of the pleural tumour. The response to both radiotherapy and chemotherapy was poor and the patient died shortly after diagnosis.
Feng
Po Hao
PH
Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Huang
Chung-Chi
CC
Wang
Chih-Wei
CW
Wu
Yao-Kuang
YK
Tsai
Ying-Huang
YH
D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism; D000328:Adult; D006801:Humans; D050835:Interferon Regulatory Factors / Q000378:metabolism; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D010265:Paraproteinemias / Q000175:diagnosis* / Q000378:metabolism; D010266:Paraproteins / Q000378:metabolism; D010954:Plasmacytoma / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D016066:Pleural Effusion, Malignant / Q000175:diagnosis* / Q000378:metabolism; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D013902:Radiography, Thoracic; D053668:Syndecan-1 / Q000378:metabolism; D000099218:Interferon Regulatory Factor-4
D051997:ADP-ribosyl Cyclase 1; D050835:Interferon Regulatory Factors; D010266:Paraproteins; D053668:Syndecan-1; D000099218:Interferon Regulatory Factor-4