title: Sequential pancreaticoduodenectomy after living donor liver transplantation for cholangiocarcinoma.
abstract: Liver transplantation (LT) for patients with primary sclerosing cholangitis (PSC) is often contraindicated due to concomitant occurrence of cholangiocarcinoma (CC). Cases of simultaneous pancreaticoduodenectomy (PD) with LT have been sporadically reported; however, the applicability of such an invasive procedure to patients with CC has not been validated. We report here a case of sequential PD performed 44 days after a successful living donor liver transplantation (LDLT) using a left lobe graft. Although a clear pancreatic juice leakage through the drain persisted for days after surgery, the patient recovered from the complication and was discharged 32 days after the procedure. Currently, 1 year after LDLT, the patient is doing well with no evidence of recurrence. In conclusion, a sequential PD following LDLT is a safe and feasible option to treat CC complicating PSC. Long-term follow-up and accumulation of cases are necessary to evaluate the effectiveness of this procedure for this complicated disease.
authors: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. ysoejima@surg2.med.kyushu-u.ac.jp
authors: Y
authors: Y
authors: Soejima
authors: S
authors: S
authors: Ueda
authors: K
authors: K
authors: Sanefuji
authors: H
authors: H
authors: Kayashima
authors: T
authors: T
authors: Yoshizumi
authors: T
authors: T
authors: Ikegami
authors: Y
authors: Y
authors: Yamashita
authors: K
authors: K
authors: Sugimachi
authors: T
authors: T
authors: Iguchi
authors: A
authors: A
authors: Taketomi
authors: Y
authors: Y
authors: Maehara
mesh_terms: D000328:Adult; D002454:Cell Differentiation; D018281:Cholangiocarcinoma / Q000601:surgery / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000601:surgery / Q000628:therapy*; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008953:Models, Anatomic; D009361:Neoplasm Invasiveness; D016577:Pancreaticoduodenectomy / Q000379:methods*; D013997:Time Factors