Strategies to overcome pH-dependent solubility of weakly basic drugs by using different types of alginates.
Weakly basic drugs demonstrate higher solubility at lower pH, thus often leading to faster drug release at lower pH. The objective of this study was to achieve pH-independent release of weakly basic drugs from extended release formulations based on the naturally occurring polymer sodium alginate. Three approaches to overcome the pH-dependent solubility of the weakly basic model drug verapamil hydrochloride were investigated. First, matrix tablets were prepared by direct compression of drug substance with different types of sodium alginate only. Second, pH-modifiers were added to the drug/alginate matrix systems. Third, press-coated tablets consisting of an inner pH-modifier tablet core and an outer drug/sodium alginate coat were prepared. pH-Independent drug release was achieved from matrix tablets consisting of selected alginates and drug substance only. Alginates are better soluble at higher pH. Therefore, they are able to compensate the poor solubility of weakly basic drugs at higher pH as the matrix of the tablets dissolves faster. This approach was successful when using alginates that demonstrated fast hydration and erosion at higher pH. The approach failed for alginates with less-pronounced erosion at higher pH. The addition of fumaric acid to drug/alginate-based matrix systems decreased the microenvironmental pH within the tablets thus increasing the solubility of the weakly basic drug at higher pH. Therefore, pH-independent drug release was achieved irrespective of the type of alginate used. Drug release from press-coated tablets did not provide any further advantages as compound release remained pH-dependent.
Gutsche
S
S
Pharmaceutical Technology, Bayer Schering Pharma AG, Berlin, Germany.
Krause
M
M
Kranz
H
H
D000464:Alginates / Q000737:chemistry*; D016503:Drug Delivery Systems; D005650:Fumarates / Q000737:chemistry; D006244:Hardness; D006863:Hydrogen-Ion Concentration; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical; D014700:Verapamil / Q000008:administration & dosage / Q000737:chemistry
D000464:Alginates; D005650:Fumarates; D013607:Tablets; C032005:fumaric acid; D014700:Verapamil