Unusual production of glutathione in Actinobacteria.
Most Actinobacteria produce mycothiol as the major thiol. In addition to mycothiol Rhodococcus AD45 generates a substantial level of glutathione possibly using genes acquired in a lateral transfer. Instead of mycothiol, Rubrobacter radiotolerans and Rubrobacter xylanophilus produce glutathione, whose synthesis appears to involve enzymes substantially different from those in other organisms.
Johnson
Todd
T
Department of Biology, California State University-Fresno, Fresno, CA 93740, USA.
Newton
Gerald L
GL
Fahey
Robert C
RC
Rawat
Mamta
M
D039903:Actinobacteria / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D003545:Cysteine / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D006020:Glycopeptides / Q000378:metabolism; D007294:Inositol / Q000378:metabolism; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D001426:Bacterial Proteins; D006020:Glycopeptides; C089265:mycothiol; D007294:Inositol; D005978:Glutathione; D003545:Cysteine