Electrochemical and ultraviolet-visible spectroscopic studies on the interaction of deoxyribonucleic acid with vitamin B6.
Studies on the interaction of DNA with vitamin B(6) were carried out with a DNA-modified electrode by electrochemistry and Ultraviolet-visible spectroscopy. The results showed that there exists the supra-molecule interaction between base groups on DNA and vitamin B(6) by forming hydrogen binding, the binding equilibrium constant of the interaction is equal to 115.3 M(-1), the binding ratio of nucleotide to vitamin B(6) is 5:1. Based on the electrochemical and Ultraviolet-visible spectrum studies the interaction mode of DNA with vitamin B(6) was explored.
Liu
Shou-Qing
SQ
College of Chemistry and Bioengineering, Suzhou University of Science and Technology, Suzhou 215009, China. shouqing_liu@hotmail.com
Cao
Mei-Ling
ML
Dong
Shu-Ling
SL
D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D004563:Electrochemistry; D004566:Electrodes; D006860:Hydrogen Bonding; D013056:Spectrophotometry, Ultraviolet; D025101:Vitamin B 6 / Q000737:chemistry*
D025101:Vitamin B 6; D004247:DNA