title: Parkinson's disease influences the perioperative risk profile in surgery.
abstract: OBJECTIVE
  Aim of this study was to define the perioperative risk profile in surgery of patients suffering from Parkinson's disease (PD) in order to improve treatment options in these patients.
  
  
  METHODS
  Over a period of 13 years, 51 patients suffering from Parkinson's disease treated in the departments of general, visceral, thoracic, vascular, and trauma surgery were retrospectively compared using matched-pair analysis with 51 controls not affected by PD. Both groups of patients were assessed regarding morbidity and mortality, length of treatment, and rehabilitation.
  
  
  RESULTS
  Surgical patients suffering from Parkinson's disease showed an increase in risk of morbidity. Postoperative falls occurred more commonly (entire cohort, p < 0.03). In PD patients treated in the trauma surgery department, postoperative falls (p < 0.04), postoperative stay (p < 0.03), and overall duration of treatment (p < 0.02) were significantly longer than in patients without PD. PD patients of the trauma unit could be discharged home less often for ambulantory rehabilitation after in-patient treatment (p < 0.03).
  
  
  CONCLUSIONS
  Concomitant Parkinson's disease is a significant factor of perioperative morbidity in surgical patients, especially of patients treated in the trauma unit. Perioperative morbidity in PD patients may be influenced by early diagnostic and therapeutic measures.
authors: Department of Orthopaedics and Trauma Surgery, University Hospital of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany. Marcus.Mueller@ukb.uni-bonn.de
authors: Marcus C
authors: MC
authors: Mueller
authors: Ulf
authors: U
authors: Jüptner
authors: Ullrich
authors: U
authors: Wuellner
authors: Stefan
authors: S
authors: Wirz
authors: Andreas
authors: A
authors: Türler
authors: Andreas
authors: A
authors: Hirner
authors: Jens
authors: J
authors: Standop
mesh_terms: D000058:Accidental Falls / Q000706:statistics & numerical data; D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D010300:Parkinson Disease / Q000150:complications*; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D013514:Surgical Procedures, Operative; D013997:Time Factors; D016896:Treatment Outcome