title: The discovery of pyrano[3,4-b]indole-based allosteric inhibitors of HCV NS5B polymerase with in vivo activity.
authors: TetraLogic Pharmaceuticals, 343 Phoenixville Pike, Malvern, PA 19355, USA. mlaporte@tetralogicpharma.com
authors: Matthew G
authors: MG
authors: Laporte
authors: Randy W
authors: RW
authors: Jackson
authors: Tandy L
authors: TL
authors: Draper
authors: Janet A
authors: JA
authors: Gaboury
authors: Kristin
authors: K
authors: Galie
authors: Torsten
authors: T
authors: Herbertz
authors: Alison R
authors: AR
authors: Hussey
authors: Susan R
authors: SR
authors: Rippin
authors: Christopher A
authors: CA
authors: Benetatos
authors: Srinivas K
authors: SK
authors: Chunduru
authors: Joel S
authors: JS
authors: Christensen
authors: Glen A
authors: GA
authors: Coburn
authors: Christopher J
authors: CJ
authors: Rizzo
authors: Gerry
authors: G
authors: Rhodes
authors: John
authors: J
authors: O'Connell
authors: Anita Y M
authors: AY
authors: Howe
authors: Tarek S
authors: TS
authors: Mansour
authors: Marc S
authors: MS
authors: Collett
authors: Daniel C
authors: DC
authors: Pevear
authors: Dorothy C
authors: DC
authors: Young
authors: Tiejun
authors: T
authors: Gao
authors: D Lorne J
authors: DL
authors: Tyrrell
authors: Norman M
authors: NM
authors: Kneteman
authors: Christopher J
authors: CJ
authors: Burns
authors: Stephen M
authors: SM
authors: Condon
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016174:Hepacivirus / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D051379:Mice; D016513:Mice, SCID; D008822:Mice, Transgenic; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012367:RNA, Viral / Q000097:blood / Q000302:isolation & purification; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D007211:Indoles; D011714:Pyrans; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase