title: Neuropathology of italian cats in feline spongiform encephalopathy surveillance.
abstract: Feline spongiform encephalopathy (FSE) is a transmissible spongiform encephalopathy associated with the consumption of feedstuffs contaminated with tissue from bovine spongiform encephalopathy-affected cattle and characterized by the accumulation in the central nervous system of an abnormal isoform of the prion protein (PrP(sc)). Clinically, it presents as a progressive fatal neurologic syndrome that is not easily distinguished from other feline neurologic conditions. Most cases of FSE have been reported in England, where it was first detected in 1990, but a few cases have been reported from other European countries. To identify possible cases of FSE in Italy, the Italian Ministry of Health funded a 2-year surveillance project during which the brains from 110 domestic cats with neurologic signs were evaluated histologically for spongiform encephalopathy and immunohistochemically to detect PrP(sc). Although no cases of FSE were found, the study proved useful in monitoring the Italian cat population for other neurologic diseases: neoplasia (21.8%), toxic-metabolic encephalopathy (18.2%), granulomatous encephalitis (15.5%), suppurative encephalitis (4.6%), trauma (3.6%), circulatory disorders (3.6%), degeneration (2.7%), nonsuppurative encephalitis (2.7%), and neuromuscular diseases (1.8%). No histologic lesions were found in 20% of the brains, and samples from 5.5% of the cats were rejected as unsuitable.
authors: CEA - Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, 10154 Torino (Italy).
authors: B
authors: B
authors: Iulini
authors: C
authors: C
authors: Cantile
authors: M T
authors: MT
authors: Mandara
authors: C
authors: C
authors: Maurella
authors: G R
authors: GR
authors: Loria
authors: M
authors: M
authors: Castagnaro
authors: C
authors: C
authors: Salvadori
authors: C
authors: C
authors: Porcario
authors: C
authors: C
authors: Corona
authors: A Z
authors: AZ
authors: Perazzini
authors: A
authors: A
authors: Maroni
authors: M
authors: M
authors: Caramelli
authors: C
authors: C
authors: Casalone
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D002415:Cats; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D007558:Italy / Q000453:epidemiology; D008297:Male; D017096:Prion Diseases / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D011328:Prions / Q000378:metabolism*
chemical_list: D011328:Prions