title: Spermiogenesis defects in human: detection of transition proteins in semen from some infertile men.
abstract: Semen samples from 60 infertile men were examined by flow cytometry following propidium iodide staining. Of these, 23 samples contained young haploid cells. Transition proteins (TP1 and/or TP2) were detected in 12 of these, using immunohistochemical staining. The presence of TPs in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa. Cells of this type were found in semen from patients with nonobstructive azoospermia, severe to extreme cases of oligozoospermia, asthenozoospermia and teratozoospermia.
authors: Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
authors: S
authors: S
authors: Becker
authors: Y
authors: Y
authors: Soffer
authors: L M
authors: LM
authors: Lewin
authors: L
authors: L
authors: Yogev
authors: L
authors: L
authors: Shochat
authors: R
authors: R
authors: Golan
mesh_terms: D002454:Cell Differentiation / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D006801:Humans; D007248:Infertility, Male / Q000378:metabolism* / Q000473:pathology; D008297:Male; D012661:Semen / Q000378:metabolism*; D013087:Spermatids / Q000473:pathology; D013091:Spermatogenesis / Q000502:physiology*; D013094:Spermatozoa / Q000473:pathology
chemical_list: D002868:Chromosomal Proteins, Non-Histone; C053886:spermatid transition proteins