[Research Progress of microRNAs and human hematological diseases - review].
The microRNAs (miRNAs) are an evolutionarily conserved class of 22 nucleotide (19 - 25 nt) non-coding RNAs. The miRNAs are partially complementary to 3' untranslated region of target mRNA, resulting in the repression of gene expression at post-transcriptional level. The miRNAs have been associated with diverse biological processes. This review summarizes recent progress of research on the characteristics and function of miRNAs, and the role of miRNAs in hematological malignancy development.
Meng
Dong-Mei
DM
Department of Hematology, The Affiliated Hospital, Medical College, Qingdao University, Qingdao 266003, Shandong Province, China.
Miao
Zhi-Min
ZM
D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000502:physiology*
D035683:MicroRNAs