title: Right ventricular remodeling and dysfunction with subsequent annular dilatation and tethering as a mechanism of isolated tricuspid regurgitation.
abstract: BACKGROUND
  Secondary tricuspid regurgitation (TR) as a result of pulmonary hypertension and/or left-sided heart disease is caused by tricuspid valve (TV) annular dilatation and tethering of the tricuspid leaflet after right ventricular (RV) dilatation. However, the mechanism of isolated TR without significant pulmonary hypertension remains unknown. The present study investigated the RV function and TV deformations in patients with isolated TR to find out the mechanism and etiology of the disease.
  
  
  RESULTS
  Twelve patients with isolated, severe TR were included. RV area, volume, ejection fraction (EF), tenting distance and tenting area were measured. These parameters were compared with 12 age-and gender-matched controls and 12 patients with secondary TR. The cause of isolated TR was incomplete coaptation associated with annular dilatation without other problems. Compared with the controls, RV end-diastolic volumes and annular diameters were significantly larger and RVEF was significantly lower in patients with isolated TR. Tenting area and tenting distance were also significantly higher. However, there were no significant differences in these parameters between patients with isolated and secondary TR.
  
  
  CONCLUSIONS
  Isolated TR was associated with RV remodeling, systolic dysfunction and resultant annular dilatation and tethering of tricuspid leaflets.
authors: Division of Cardiology, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Hye-Sun
authors: HS
authors: Seo
authors: Jong-Won
authors: JW
authors: Ha
authors: Jae Youn
authors: JY
authors: Moon
authors: Eui-Young
authors: EY
authors: Choi
authors: Se-Joong
authors: SJ
authors: Rim
authors: Yangsoo
authors: Y
authors: Jang
authors: Namsik
authors: N
authors: Chung
authors: Won-Heum
authors: WH
authors: Shim
authors: Seung-Yun
authors: SY
authors: Cho
authors: Sung Soon
authors: SS
authors: Kim
mesh_terms: D004108:Dilatation, Pathologic / Q000503:physiopathology; D004452:Echocardiography; D006801:Humans; D012189:Retrospective Studies; D014262:Tricuspid Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology*; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D016278:Ventricular Function, Right / Q000502:physiology*; D020257:Ventricular Remodeling / Q000502:physiology*