title: Efficacy and safety of using mesh or grafts in surgery for anterior and/or posterior vaginal wall prolapse: systematic review and meta-analysis.
abstract: BACKGROUND
  The efficacy and safety of mesh/graft in surgery for anterior or posterior pelvic organ prolapse is uncertain.
  
  
  OBJECTIVE
  To systematically review the efficacy and safety of mesh/graft for anterior or posterior vaginal wall prolapse surgery.
  
  
  METHODS
  Electronic databases and conference proceedings were searched, experts and manufacturers contacted, and reference lists of retrieved papers scanned.
  
  
  METHODS
  Randomised controlled trials (RCTs), nonrandomised comparative studies, registries, case series involving at least 50 women, and RCTs published as conference abstracts from 2005 onwards.
  
  
  METHODS
  One reviewer screened titles/abstracts, undertook data extraction, and assessed study quality. Data analysis was conducted for three subgroups: anterior, posterior, and anterior and/or posterior repair (not reported separately).
  
  
  RESULTS
  Forty-nine studies involving 4569 women treated with mesh/graft were included. Study quality was generally high. Median follow up was 13 months (range 1-51 months). In anterior repair, there was short-term evidence that mesh/graft (any type) significantly reduced objective prolapse recurrence rates compared with no mesh/graft (relative risk 0.48, 95% CI 0.32-0.72). Nonabsorbable synthetic mesh had a significantly lower objective prolapse recurrence rate (8.8%, 48/548) than absorbable synthetic mesh (23.1%, 63/273) and biological graft (17.9%, 186/1041), but a higher erosion rate (10.2%, 68/666) than absorbable synthetic mesh (0.7%, 1/147) and biological graft (6.0%, 35/581). There was insufficient information to compare any of the other outcomes regardless of prolapse type.
  
  
  CONCLUSIONS
  Evidence for most outcomes was too sparse to provide meaningful conclusions. Rigorous long-term RCTs are required to determine the comparative efficacy of using mesh/graft.
authors: Health Services Research Unit, University of Aberdeen, Aberdeen, UK. x.jia@abdn.ac.uk
authors: X
authors: X
authors: Jia
authors: C
authors: C
authors: Glazener
authors: G
authors: G
authors: Mowatt
authors: G
authors: G
authors: MacLennan
authors: C
authors: C
authors: Bain
authors: C
authors: C
authors: Fraser
authors: J
authors: J
authors: Burr
mesh_terms: D000328:Adult; D000368:Aged; D004868:Equipment Failure; D005260:Female; D006801:Humans; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D013524:Surgical Flaps / Q000009:adverse effects / Q000592:standards*; D013526:Surgical Mesh / Q000009:adverse effects / Q000592:standards*; D016896:Treatment Outcome; D014596:Uterine Prolapse / Q000601:surgery*