title: Low density, non-ablative fractional CO2 laser rejuvenation.
abstract: OBJECTIVE
  Fractional skin rejuvenation has gained increased interest since its introduction in 2003. Both non-ablative and ablative lasers as well as different treatment techniques have been devised. Recent clinical studies indicate that a paradigm of low spot density combined with high fluences tend to produce better clinical results and less risk of post-inflammatory hyperpigmentation in darker skin types. The present study is focused on investigations of the clinical outcome by non-ablative fractional CO(2) treatments with a single pass with low spot density.
  
  
  METHODS
  A CO(2) laser was equipped with a scanner enabling it to perform fractional treatments with 36, 64 or 100 microthermal zones (MTZ)/cm(2). Twelve patients participated in the study. The perioral area was treated three times with 1-month intervals using a spot density of 64 MTZ/cm(2), a spot diameter of 0.5 mm, a micro-beam energy of 36-60 mJ, and a pulse duration of 3-5 milliseconds. Follow-up was performed 3 months after the last treatment.
  
  
  RESULTS
  At the 3-month follow-up 72.7% of the volunteers had obtained improvement in ultrasonographically determined dermal density, and the average improvement was 40.2% (SD: 48.0%). This improvement was statistically significant (P<0.006). Eighty percent of the volunteers rated the reduction in visible perioral wrinkles to be fair, good or excellent. For reduction of irregular pigmentation, fair, good or excellent clearance was reported by 62.5% of the volunteers.
  
  
  CONCLUSIONS
  The present study demonstrates subjective improvements in wrinkles, skin texture and mottled pigmentation as well as statistically significant objectively measured improvements in ultrasonographical dermal density after three non-ablative fractional CO(2) laser treatments.
authors: Molholm Research, 7100 Vejle, Denmark. dan-medico@mail.dk
authors: Kaare
authors: K
authors: Christiansen
authors: Peter
authors: P
authors: Bjerring
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D054020:Lasers, Gas; D028022:Low-Level Light Therapy; D008875:Middle Aged; D012060:Rejuvenation; D015361:Rhytidoplasty / Q000379:methods*