title: Argatroban anticoagulation for cardiac surgery with cardiopulmonary bypass in an infant with double outlet right ventricle and a history of heparin-induced thrombocytopenia.
abstract: Heparin-induced thrombocytopenia (HIT) is a life-threatening complication of heparin therapy. Anticoagulation in pediatric patients with HIT is challenging as there are no approved heparin substitutes. We report the use of the anticoagulant argatroban for cardiac surgery with cardiopulmonary bypass in an infant with double outlet right ventricle and a history of HIT.
authors: Cardiothoracic Surgery, Cardiovascular Surgical Associates, Las Vegas, Nevada, USA.
authors: Michael L
authors: ML
authors: Ciccolo
authors: Jonathan
authors: J
authors: Bernstein
authors: Juan C
authors: JC
authors: Collazos
authors: Ruben J
authors: RJ
authors: Acherman
authors: Humberto
authors: H
authors: Restrepo
authors: James M
authors: JM
authors: Winters
authors: Justin
authors: J
authors: Krueger
authors: William N
authors: WN
authors: Evans
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001120:Arginine / Q000031:analogs & derivatives; D019917:Blood Vessel Prosthesis Implantation; D002315:Cardiopulmonary Bypass; D002675:Child, Preschool; D004310:Double Outlet Right Ventricle / Q000601:surgery*; D004374:Ductus Arteriosus, Patent / Q000601:surgery; D005260:Female; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D010875:Pipecolic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D011666:Pulmonary Valve Stenosis / Q000601:surgery; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced
chemical_list: D000925:Anticoagulants; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban