[Use of laws of interelement interactions for understanding of mechanisms of various human diseases].
The review considers the basic laws of interaction of elements in real physiological conditions of metabolism. The law of replacement and two it consequences have been formulated taking into account a major principle of cybernetics, the feedback principle. A rule of a fractional threshold and the law of toxicity based on the Mertz's rules have been formulated. These laws have been used here for consideration of mechanisms of occurrence and development of apoptosis and also side-effects of statins. Study of bioinorganic mechanisms of different diseases is a erspective way for search of complex connections of metals and ligands, capable to interaction with initiators of chain reactions, and for a finding of substances--inhibitors these reactions.
Barashkov
G K
GK
Zaĭtseva
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D000375:Aging / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002412:Cations; D002614:Chelating Agents / Q000378:metabolism*; D004194:Disease / Q000209:etiology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D008024:Ligands; D008670:Metals / Q000378:metabolism* / Q000633:toxicity; D014131:Trace Elements / Q000378:metabolism
D002412:Cations; D002614:Chelating Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008024:Ligands; D008670:Metals; D014131:Trace Elements