title: Interstitial lung disease associated with collagen vascular disorders: disease quantification using a computer-aided diagnosis tool.
abstract: The purpose of this study was to evaluate a computer-aided diagnosis (CAD) tool compared to human observers in quantification of interstitial lung disease (ILD) in patients with collagen-vascular disorders. A total of 52 patients with rheumatoid arthritis (n=24), scleroderma (n=14) and systemic lupus erythematosus (n=14) underwent thin-section CT. Two independent observers assessed the extent of ILD (EoILD), reticulation (EoRet) and ground-glass opacity (EoGGO). CAD assessed EoILD twice. Pulmonary function tests were obtained. Statistical evaluation used 95% limits of agreement and linear regression analysis. CAD correlated well with diffusing capacity (DL(CO)) (R= -0.531, P<0.0001) and moderately with forced vital capacity (FVC) (R= -0.483, P=0.0008). There was close correlation between CAD and the readers (EoILD vs. CAD: R=0.716, P<0.0001; EoRet vs. CAD: R=0.69, P<0.0001). Subgroup analysis including patients with minimal EoGGO (<15%) strengthened the correlations between CAD and the readers, readers and PFT, and CAD and PFT. EoILD by readers correlated strongly with DL(CO) (R= -0.705, P<0.0001) and moderately with FVC (R= -0.559, P=0.0002). EoRet correlated closely with DL(CO) and moderately with FVC (DL(CO): R= -0.663; FVC: R = -0.436; P <or= 0.005). The CAD system is a promising tool for ILD quantification, showing close correlation with human observers and physiologic impairment.
authors: Department of Radiology, University Hospital of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany. kmarten@med.uni-goettingen.de
authors: K
authors: K
authors: Marten
authors: V
authors: V
authors: Dicken
authors: C
authors: C
authors: Kneitz
authors: M
authors: M
authors: Höhmann
authors: W
authors: W
authors: Kenn
authors: D
authors: D
authors: Hahn
authors: C
authors: C
authors: Engelke
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003095:Collagen Diseases / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D012044:Regression Analysis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods; D014652:Vascular Diseases / Q000175:diagnosis* / Q000378:metabolism*