Reticulated phototoxic eruption in a patient on long-term diltiazem therapy.
Diltiazem hydrochloride is a commonly prescribed medication in the treatment of cardiovascular disease. A case of diltiazem-induced hyperpigmentation in a patient after significant sun exposure is reported. The morphological appearance was reticulated and slate-gray to blue in color. The pathogenesis of the hyperpigmentation is discussed and possible treatment options are reviewed.
Hanson
Miriam
M
Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Petronic-Rosic
Vesna
V
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000009:adverse effects* / Q000627:therapeutic use; D003329:Coronary Vasospasm / Q000150:complications / Q000188:drug therapy; D017484:Dermatitis, Phototoxic / Q000188:drug therapy / Q000473:pathology*; D004110:Diltiazem / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000188:drug therapy / Q000473:pathology*; D005447:Fluocinonide / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced / Q000473:pathology; D015603:Keratinocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012867:Skin / Q000473:pathology*
D000893:Anti-Inflammatory Agents; D002121:Calcium Channel Blockers; D005447:Fluocinonide; D004110:Diltiazem