In vitro permeation studies of nanoemulsions containing ketoprofen as a model drug.
We prepared a nanoemulsion system with benzyl alcohol/ ethanol/Solutol/smash(R) HS 15 /water. Ketoprofen was used as a model drug in this study. The nanoemulsions of this system evidenced a high degree of stability. The droplet diameter did not change over a period of at least 3 months. The nanoemulsion containing 4% benzyl alcohol evidenced a permeation rate higher than was observed with the 1% and 2% nanoemulsions. Also the nanoemulsion containing 1% Solutol(R) HS 15 provided a permeation rate higher than was seen with the 2% and 4% nanoemulsions. All ketoprofen-loaded nanoemulsions enhanced the in vitro permeation rate through mouse skins as compared to the control.
Kim
Beom Su
BS
Laboratory of Enzyme Technology, College of Natural Science, Chonju, Republic of Korea.
Won
Myoung
M
Lee
Kang Min
KM
Kim
Cheo Sang
CS
D000279:Administration, Cutaneous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D019905:Benzyl Alcohol / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D004355:Drug Stability; D004655:Emulsions; D000431:Ethanol / Q000737:chemistry; D066298:In Vitro Techniques; D007660:Ketoprofen / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D051379:Mice; D053758:Nanoparticles; D010316:Particle Size; D010539:Permeability; D011092:Polyethylene Glycols / Q000737:chemistry; D012867:Skin / Q000378:metabolism*; D013229:Stearic Acids / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D004655:Emulsions; D013229:Stearic Acids; D014867:Water; D000431:Ethanol; D011092:Polyethylene Glycols; C067028:Solutol HS 15; D007660:Ketoprofen; D019905:Benzyl Alcohol