title: Preparation and biological evaluation of 5-substituted retinoic acids.
abstract: Various 5-substituted retinoic acids were prepared by a palladium-catalyzed cross coupling reactions of vinyl nonaflates and E- or Z-3-tributylstannyl-2-beten-1-ol as a key reaction. These coupling products were then converted to the corresponding all-E- and 9Z-retinoic acid analogs via Horner-Emmons reaction and subsequent basic hydrolysis, and their biological activities were evaluated. The all-E-derivatives, 5-butyl and isobutyl analogs exhibited stronger effects for anti-proliferative and differentiation-inducing activities in HL-60 cells. In contrast, in 9Z-derivatives, none of the analogs showed any activity.
authors.affiliation: Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada, Kobe 658-8558, Japan. a-wada@kobepharma-u.ac.jp
authors.forename: Akimori
authors.initials: A
authors.lastname: Wada
authors.forename: Naomi
authors.initials: N
authors.lastname: Matsuura
authors.forename: Yukari
authors.initials: Y
authors.lastname: Mizuguchi
authors.forename: Kimie
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Ito
authors.forename: Toshio
authors.initials: T
authors.lastname: Okano