Total synthesis of (-)-histrionicotoxin 285A and (-)-perhydrohistrionicotoxin.
Starting from commercially available ( S)-glycidol, and via a common intermediate, the total synthesis of (-)-histrionicotoxin 285A and (-)-perhydrohistrionicotoxin has been achieved. Key to this synthesis was the efficient construction of a six-membered, chiral, cyclic nitrone.
Macdonald
James M
JM
CSIRO, Division of Molecular and Health Technologies, Bag 10, Clayton South, Victoria 3169, Australia.
Horsley
Helen T
HT
Ryan
John H
JH
Saubern
Simon
S
Holmes
Andrew B
AB