Twisted epithelial-mesenchymal transition blocks senescence.
The epithelial-mesenchymal transition (EMT) is a cellular transdifferentiation program that enables epithelial cancer cells to acquire traits of high-grade malignancy, notably invasive and metastatic powers. A new study indicates that it may also function early in tumour progression by preventing oncogene-induced senescence.
Weinberg
Robert A
RA
Whitehead Institute for Biomedical Research, Ludwig Center for Molecular Oncology, MIT Department of Biology, Cambridge, MA 02142, USA. weinberg@wi.mit.edu