The influence of gene conversion on linkage disequilibrium around a selective sweep.
In a 2007 article, McVean studied the effect of recombination on linkage disequilibrium (LD) between two neutral loci located near a third locus that has undergone a selective sweep. The results demonstrated that two loci on the same side of a selected locus might show substantial LD, whereas the expected LD for two loci on opposite sides of a selected locus is zero. In this article, we extend McVean's model to include gene conversion. We show that one of the conclusions is strongly affected by gene conversion: when gene conversion is present, there may be substantial LD between two loci on opposite sides of a selective sweep.
Jones
Danielle A
DA
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA. djones@fas.harvard.edu
Wakeley
John
J