title: [Role of mitogen-activated protein kinase pathway in chloracne].
abstract: OBJECTIVE
  To investigate the role of mitogen-activated protein kinase (MAPK) signal transduction pathway in chloracne.
  
  
  METHODS
  Immunohistochemical technique was used to detect the expression of phosphorylated epidermal growth factor receptor (p-EGFR) and p-MAPK proteins in the epithelium of chloracne group and control group.
  
  
  RESULTS
  p-EGFR and p-MAPK was found in all chloracne tissues, whereas no expression of p-EGFR and p-MAPK protein was found in control group. In the skin of chloracne patients, p-EGFR was mainly distributed in the membrane and the cytoplasm, especially in the vicinity of membrane; major positive signal of p-MAPK was in core and serosity.
  
  
  CONCLUSIONS
  EGFR and MAPK phosphorylation is found in chloracne tissues. MAPK signal transduction pathway is one important molecular mechanism of chloracne.
authors.affiliation: Department of Occupational Health, School of PublicHealth, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Chun-mei
authors.initials: CM
authors.lastname: Zhang
authors.forename: Nai-jun
authors.initials: NJ
authors.lastname: Tang
authors.forename: Li
authors.initials: L
authors.lastname: Dong
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Zhao
authors.forename: Shi-wei
authors.initials: SW
authors.lastname: Ma
authors.forename: Wen-guo
authors.initials: WG
authors.lastname: Wei
authors.forename: Wan-qi
authors.initials: WQ
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Han