title: Prognosis of Japanese breast cancer based on hormone receptor and HER2 expression determined by immunohistochemical staining.
abstract: BACKGROUND
  We classified Japanese breast cancer patients based on estrogen receptor (ER), progesterone receptor (PR), and HER2 protein expression and compared their prognoses.
  
  
  METHODS
  We compared the background and prognostic factors of 600 patients with breast cancer who were assigned to the following groups: luminal A (ER + and/or PR + and HER2-; n = 431; 71.8%), luminal B (ER + and/or PR + and HER2 + ; n = 27; 4.5%), HER2 (ER-, PR-, and HER2 + ; n = 39; 6.5%) and basal-like (BBC; ER-, PR-, and HER2-; n = 103; 17.2%).
  
  
  RESULTS
  Background factors did not significantly differ among the groups. Disease-free survival rates were significantly lower for the luminal B, HER2, and BBC subtypes than for the luminal A subtype. Cancer tended to recur earlier and overall survival was significantly lower for the BBC than for the luminal A and HER2 subtypes. Overall survival rates for the luminal B, HER2, and luminal A subtypes were comparable.
  
  
  CONCLUSIONS
  The subtype distribution for Japanese and Caucasian patients was comparable. The prognosis for the BBC subtype was poorest among all subtypes. Breast cancer tended to recur earlier for the luminal B and HER2 subtypes than for the luminal A subtype; however, overall survival did not significantly differ among them.
authors.affiliation: Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan. hiro@koto.kpu-m.ac.jp
authors.forename: Hiroo
authors.initials: H
authors.lastname: Nakajima
authors.forename: Ikuya
authors.initials: I
authors.lastname: Fujiwara
authors.forename: Naruhiko
authors.initials: N
authors.lastname: Mizuta
authors.forename: Koichi
authors.initials: K
authors.lastname: Sakaguchi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Hachimine
authors.forename: Eiichi
authors.initials: E
authors.lastname: Konishi
authors.forename: Akio
authors.initials: A
authors.lastname: Yanagisawa
authors.forename: Junji
authors.initials: J
authors.lastname: Magae