title: Evaluation of substrate and inhibitor properties of a novel MDR modulator H17 towards transmembrane efflux pumps.
abstract: Substrate and inhibitor properties of H17 as novel modulator of transmembrane efflux pump activities have been characterized in an in situ absorption model. Poor substrate properties towards P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) have been demonstrated. In competition with a MRP substrate H17 proved to have strong MRP-inhibiting properties. The profile of a strong inhibitor with poor substrate properties makes H17 a perspective hopeful candidate for effective therapies of transmembrane efflux pump activities.
authors.affiliation: Baylor College of Medicine, Center for Cell and Gene Therapy, One Baylor Plaza, Houston, TX 77030, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Richter
authors.forename: Alexandra
authors.initials: A
authors.lastname: Richter
authors.forename: Andreas
authors.initials: A
authors.lastname: Langner
authors.forename: Andreas
authors.initials: A
authors.lastname: Hilgeroth