title: [Therapeutic drug monitoring: clinical practice].
abstract: When requesting a blood level measurement in the context of "Therapeutic drug monitoring" (TDM), numerous aspects have to be considered in the pre-analytical and analytical area, as in the integration of associated clinical data. This review presents therapeutic classes for which a clinical benefit of TDM is established or suggested, at least in some settings. For each class of drugs, the main pharmacokinetic, pre-analytical, analytical and clinical aspects are evaluated in the scope of such a monitoring. Each step of the TDM process is important and none should be neglected. Additional clinical trials are however warranted to better establish the exact conditions of use for such a monitoring.
authors.affiliation: Division de pharmacologie et toxicologie cliniques, CHUV et Université de Lausanne.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Widmer
authors.forename: Dominique
authors.initials: D
authors.lastname: Werner
authors.forename: Eric
authors.initials: E
authors.lastname: Grouzmann
authors.forename: Chin B
authors.initials: CB
authors.lastname: Eap
authors.forename: Oscar
authors.initials: O
authors.lastname: Marchetti
authors.forename: Aurélie
authors.initials: A
authors.lastname: Fayet
authors.forename: Chantal
authors.initials: C
authors.lastname: Csajka
authors.forename: Laurent A
authors.initials: LA
authors.lastname: Decosterd
authors.forename: Thierry
authors.initials: T
authors.lastname: Buclin