title: The impact of margin status on local recurrence following breast conserving therapy for invasive carcinoma in Manitoba.
abstract: BACKGROUND
  Histologically positive margins are generally considered unacceptable with breast conserving therapy (BCT) given the increased risk of local recurrence (LR). What constitutes an adequate negative margin remains controversial. Margin status was explored as a predictor of LR post-BCT.
  
  
  METHODS
  Manitoba women with loco-regional progression and/or mastectomy >6 months following BCT for Stage I/II invasive cancer (1995-2004) were identified from the Manitoba Cancer Registry; LR cases were confirmed by chart review. Three controls per case were matched by age, grade, stage, and adjuvant chemotherapy use. Margin status was categorized as histologically positive, < or =1 mm, < or =2 mm or >2 mm. Conditional logistic regression determined the odds ratio of LR by margin category.
  
  
  RESULTS
  There were 50 LR cases in 3,017 patients who underwent BCT, with a median follow-up of 60 months. Wider margins were associated with a non-significant reduction in LR: >1 mm versus < or =1 mm (OR 0.69; 95% CI 0.28-1.69) and >2 mm versus < or =2 mm (OR 0.90; 95% CI 0.44-1.84).
  
  
  CONCLUSIONS
  No clear benefit to wider histologically negative margins is demonstrated.
authors.affiliation: Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada. krista.hardy@yahoo.ca
authors.forename: K
authors.initials: K
authors.lastname: Hardy
authors.forename: K
authors.initials: K
authors.lastname: Fradette
authors.forename: R
authors.initials: R
authors.lastname: Gheorghe
authors.forename: L
authors.initials: L
authors.lastname: Lucman
authors.forename: S
authors.initials: S
authors.lastname: Latosinsky