Prevalence and particularities of dyslipidaemia in subjects with coronary heart disease.
The purpose of the study was to evaluate the lipid profile and the prevalence of dyslipidaemia and other risk factors in subjects with and without coronary heart disease.


METHODS
We conducted a retrospective study in 1519 subjects, admitted in Internal Medicine and Cardiology Department, Cluj-Napoca between January 2003 and December 2004. The first group consisted of 760 patients with coronary heart disease and the second group including 759 subjects in which coronary heart disease was excluded based on standard criteria. The cardiovascular risk factors and the serum lipid fractions were analyzed in order to test their relationship with the demographic characteristics and clinical forms of coronary heart disease.


RESULTS
The mean values of lipid fractions were lower in subjects with coronary heart disease than in subjects without coronary heart disease: total cholesterol (204.44 +/- 43.07 vs. 224.51 +/- 51.73 mg/dl, p = 0.0001), LDL-cholesterol (132.69 +/- 34.77 vs. 148.76 +/- 48.72 mg/dl, p = 0.0001), HDL-cholesterol (39.72 +/- 10.02 vs. 44.33 +/- 11.95 mg/dl, p = 0.0001), triglycerides (156.81 +/- 70.84 vs. 159.99 +/- 115.3 mg/dl, p = 0.517), non-HDL-cholesterol (164.72 +/- 39.9 vs. 180.19 +/- 51.58 mg/dl, p = 0.0001). The prevalence of dyslipidaemia was higher in group 1 than in group 2 (91.2% vs. 85.3%; p = 0.01). The most common lipid abnormalities in patients with coronary heat disease were increased LDL-C (84.22% vs. 81.21%, p = 0.09), followed by low HDL-C (55.26% vs. 35.57%, p = 0.001). The multivariate analysis showed that LDL-C (OR 1.27; 95% CI 1.01-1.88, p = 0.004), TC/HDL-C > 4.5 (OR 3.62; 95% CI 2.85-8.86, p = 0.001) and LDL-C/HDL-C > 3.5 (OR 4.21; 95% CI 1.89-4.66, p = 0.001) ratio, as being strongly associated with coronary events.


CONCLUSIONS
The study found a high prevalence of dyslipidaemia in Romanian patients with coronary heart disease. The most frequent lipid disorders were increased LDL-C, and low HDL-C. According to our results more than 90% of the patients with coronary heart disease are dyslipidaemic, and require non-pharmacological or pharmacological therapy.
Agoşton-Coldea
Lucica
L
"Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. lucicoldea@yahoo.fr
Zdrenghea
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D
Pop
Dana
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Crăciun
Alexandra
A
Rusu
M L
ML
Mocan
Teodora
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