A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 cases and 3,115 controls. We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13.32 (rs11083846, PRKD2; P = 3.96 x 10(-9)). These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL.
Di Bernardo
Maria Chiara
MC
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
Crowther-Swanepoel
Dalemari
D
Broderick
Peter
P
Webb
Emily
E
Sellick
Gabrielle
G
Wild
Ruth
R
Sullivan
Kate
K
Vijayakrishnan
Jayaram
J
Wang
Yufei
Y
Pittman
Alan M
AM
Sunter
Nicola J
NJ
Hall
Andrew G
AG
Dyer
Martin J S
MJ
Matutes
Estella
E
Dearden
Claire
C
Mainou-Fowler
Tryfonia
T
Jackson
Graham H
GH
Summerfield
Geoffrey
G
Harris
Robert J
RJ
Pettitt
Andrew R
AR
Hillmen
Peter
P
Allsup
David J
DJ
Bailey
James R
JR
Pratt
Guy
G
Pepper
Chris
C
Fegan
Chris
C
Allan
James M
JM
Catovsky
Daniel
D
Houlston
Richard S
RS