Anthraquinone-benzisochromanquinone dimers from the roots of Berchemia floribunda.
Four novel anthraquinone-benzisochromanquinone dimers, named floribundiquinones A, B, C, and D (1-4), along with six known anthraquinones, 10-(chrysophanol-7'-yl)-10-hydroxychrysophanol-9-anthrane (5), physcion (6), chrysophanol (7), 1,5,8-trihydroxy-3-methyl-anthraquinone (8), aloe-emodin (9), and xanthorin (10), were isolated from the roots of Berchemia floribunda. Their structures including the absolute axial stereochemistry were elucidated on the basis of spectroscopic methods. Floribundiquinones represent a novel carbon skeleton with an anthraquinone-benzisochromanquinone unit. Hepatoprotective activities were evaluated against D-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.
Wei
Xin
X
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing People's Republic of China.
Jiang
Jian-Shuang
JS
Feng
Zi-Ming
ZM
Zhang
Pei-Cheng
PC