title: Application of the fastest route algorithm in the interactive simulation of the effect of local ischemia on the ECG.
abstract: A method is described to determine the effect on the ECG of a reduced propagation velocity within an ischemic zone. The method was designed to change the activation sequence throughout the ventricles interactively, i.e. with a response time in the order of a second. The timing of ventricular ischemic activation was computed by using the fastest route algorithm, based on locally reduced values of the propagation velocities derived from a standard, normal activation sequence. The effect of these local reductions of the velocities on the total activation sequence, as well as the changes in the electrocardiogram that these produce, are presented.
authors.affiliation: Research, Medtronic SQDM, Meander 1051, 6825 MJ, Arnhem, The Netherlands. p.vandam@science.ru.nl
authors.forename: Peter M
authors.initials: PM
authors.lastname: van Dam
authors.forename: Thom F
authors.initials: TF
authors.lastname: Oostendorp
authors.forename: Adriaan
authors.initials: A
authors.lastname: van Oosterom