1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.
The design, synthesis, and structure-activity studies of a novel series of BK B(1) receptor antagonists based on a 1-benzylbenzimidazole chemotype are described. A number of compounds, for example, 38g, with excellent affinity for the cynomolgus macaque and rat bradykinin B(1) receptor were discovered.
Guo
Qin
Q
Neurogen Corporation, 35 NE Industrial Road, Branford, CT 06405, USA.
Chandrasekhar
Jayaraman
J
Ihle
David
D
Wustrow
David J
DJ
Chenard
Bertrand L
BL
Krause
James E
JE
Hutchison
Alan
A
Alderman
Dawn
D
Cheng
Charles
C
Cortright
Daniel
D
Broom
Daniel
D
Kershaw
Mark T
MT
Simmermacher-Mayer
Jean
J
Peng
Yao
Y
Hodgetts
Kevin J
KJ