title: Total synthesis of (-)-histrionicotoxin 285A and (-)-perhydrohistrionicotoxin.
abstract: Starting from commercially available ( S)-glycidol, and via a common intermediate, the total synthesis of (-)-histrionicotoxin 285A and (-)-perhydrohistrionicotoxin has been achieved. Key to this synthesis was the efficient construction of a six-membered, chiral, cyclic nitrone.
authors.affiliation: CSIRO, Division of Molecular and Health Technologies, Bag 10, Clayton South, Victoria 3169, Australia.
authors.forename: James M
authors.initials: JM
authors.lastname: Macdonald
authors.forename: Helen T
authors.initials: HT
authors.lastname: Horsley
authors.forename: John H
authors.initials: JH
authors.lastname: Ryan
authors.forename: Simon
authors.initials: S
authors.lastname: Saubern
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Holmes