title: Lifetime risk of symptomatic knee osteoarthritis.
abstract: OBJECTIVE
  To estimate the lifetime risk of symptomatic knee osteoarthritis (OA), overall and stratified by sex, race, education, history of knee injury, and body mass index (BMI).
  
  
  METHODS
  The lifetime risk of symptomatic OA in at least 1 knee was estimated from logistic regression models with generalized estimating equations among 3,068 participants of the Johnston County Osteoarthritis Project, a longitudinal study of black and white women and men age >or=45 years living in rural North Carolina. Radiographic, sociodemographic, and symptomatic knee data measured at baseline (1990-1997) and first followup (1999-2003) were analyzed.
  
  
  RESULTS
  The lifetime risk of symptomatic knee OA was 44.7% (95% confidence interval [95% CI] 40.0-49.3%). Cohort members with history of a knee injury had a lifetime risk of 56.8% (95% CI 48.4-65.2%). Lifetime risk rose with increasing BMI, with a risk of 2 in 3 among those who were obese.
  
  
  CONCLUSIONS
  Nearly half of the adults in Johnston County will develop symptomatic knee OA by age 85 years, with lifetime risk highest among obese persons. These current high risks in Johnston County may suggest similar risks in the general US population, especially given the increase in 2 major risk factors for knee OA, aging, and obesity. This underscores the immediate need for greater use of clinical and public health interventions, especially those that address weight loss and self-management, to reduce the impact of having knee OA.
authors.affiliation: Business Computer Applications, Atlanta, Georgia, USA. lmurphy1@cdc.gov
authors.forename: Louise
authors.initials: L
authors.lastname: Murphy
authors.forename: Todd A
authors.initials: TA
authors.lastname: Schwartz
authors.forename: Charles G
authors.initials: CG
authors.lastname: Helmick
authors.forename: Jordan B
authors.initials: JB
authors.lastname: Renner
authors.forename: Gail
authors.initials: G
authors.lastname: Tudor
authors.forename: Gary
authors.initials: G
authors.lastname: Koch
authors.forename: Anca
authors.initials: A
authors.lastname: Dragomir
authors.forename: William D
authors.initials: WD
authors.lastname: Kalsbeek
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Luta
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Jordan