title: NCAM as a cystogenesis marker gene of PKD2 overexpression.
abstract: ADPKD (Autosomal Dominant Polycystic Kidney Disease) is characterized by the progressive expansion of multiple cystic lesions in the kidneys. ADPKD is caused by mutations in Ed-pl. consider PKD1 and PKD2. Recently a relation between c-myc and the pathogenesis of ADPKD was reported. In addition, c-Myc is a downstream effector of PKD1. To identify the gene regulated by PKD2 and c-Myc, we performed gene expression profiling in PKD2 and c-Myc overexpressing cells using a human 8K cDNA microarray. NCAM (neuronal cell adhesion molecule) levels were significantly reduced in PKD2 overexpressing systems in vitro and in vivo. These results suggest that NCAM is an important molecule in the cystogenesis induced by PKD2 overexpression.
authors.affiliation: Department of Biological Science, Sookmyung Women's University, Seoul 140-742, Korea.
authors.forename: Kyung Hyun
authors.initials: KH
authors.lastname: Yoo
authors.forename: Tae Young
authors.initials: TY
authors.lastname: Lee
authors.forename: Moon Hee
authors.initials: MH
authors.lastname: Yang
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Park
authors.forename: Yeon Joo
authors.initials: YJ
authors.lastname: Yook
authors.forename: Hyo Soo
authors.initials: HS
authors.lastname: Lee
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Park