title: Aggressive CD5-positive B-cell lymphoma after remission of CD5-negative follicular lymphoma with distinct immunoglobulin heavy chain rearrangement and translocation.
abstract: We report a unique, aggressive B-cell lymphoma that developed after the long-term remission of follicular lymphoma (FL). FL cells were negative for CD5, whereas aggressive lymphoma cells were positive for CD5. In FL, one immunoglobulin heavy chain gene (IGH) allele underwent V/D/J recombination and another t(14;18)(q32;q21). In aggressive lymphoma, one IGH allele underwent D/J recombination and another translocation, but not t(14;18)(q32;q21). An aggressive lymphoma-specific D/J sequence was detected in FL tissue. Our results indicated that the two tumors arose from distinct B cells and that they existed concurrently in the same lymph node.
authors.affiliation: Department of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan. sonoki@wakayama-med.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sonoki
authors.affiliation: Department of Surgical Pathology, Kumamoto University School of Medicine, Kumamoto, Japan.
authors.forename: Sonoko
authors.initials: S
authors.lastname: Ishihara
authors.affiliation: Department of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.
authors.forename: Shima
authors.initials: S
authors.lastname: Uneda
authors.affiliation: Department of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Hanaoka
authors.affiliation: Department of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.
authors.forename: Miwa
authors.initials: M
authors.lastname: Kurimoto
authors.affiliation: Department of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuoka
authors.affiliation: Department of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakakuma