title: The effect of combretastatin A4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on water diffusion and blood perfusion in tumours.
abstract: OBJECTIVE
  To evaluate the effect of the vascular disrupting drugs combretastatin A-4 disodium phosphate (CA4DP) and 5,6-dimethylxanthenone-4-acetic acid (DMXAA) on the intra/extracellular volume fraction of water and blood perfusion in tumours using MRI.
  
  
  METHODS
  Mice with C3H mammary carcinomas underwent repeated MRI T2-weighted imaging, water-diffusion and perfusion measurements before and up to 6-hours following CA4DP and DMXAA treatment.
  
  
  RESULTS
  CA4DP treatment caused an increase in water diffusion in those tumour areas that presented the lowest blood perfusion, however this appeared only after five hours. The blood perfusion in highly perfused tumour regions decreased immediately after administration of CA4DP. DMXAA treatment caused an early decrease in water diffusion in the low-perfused tumour segments and followed by a subsequent decrease in the remaining part of the tumour. The blood perfusion decreased early in all parts of the tumour.
  
  
  CONCLUSIONS
  The effect of CA4DP and DMXAA on tumour blood flow was comparable. The reduction in regional blood flow caused by CA4DP in the whole tumour segment occurred early, however, changes in ADC after DMXAA appeared more extended and earlier than after CA4DP treatment, especially in tumour areas already suffering from a low blood perfusion.
authors.affiliation: MR Research Centre, Aarhus University Hospital, Aarhus N, Denmark. gangchen@mr.au.dk
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Michael R
authors.initials: MR
authors.lastname: Horsman
authors.forename: Michael
authors.initials: M
authors.lastname: Pedersen
authors.forename: Qi
authors.initials: Q
authors.lastname: Pang
authors.forename: Hans
authors.initials: H
authors.lastname: Stødkilde-Jørgensen