Diastereoselective synthesis of N-Boc-norpandamarilactonine-B and pandamarilactonine-A.
Optically pure N-Boc-norpandamarilactonine-B was diastereoselectively synthesized starting from L-serine by employing a double ring closing metathesis (RCM) of a tetraene derivative as a key reaction. N-Boc-norpandamarilactonine-B obtained was further converted to pandamarilactonine-A.
Honda
Toshio
T
Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan. honda@hoshi.ac.jp
Katoh
Misugi
M
Ushiwata
Makoto
M
Shigehisa
Hiroki
H