title: Bioremediation: environmental clean-up through pathway engineering.
abstract: Given the immense risk posed by widespread environmental pollution by inorganic and organic chemicals, novel methods of decontamination and clean-up are required. Owing to the relatively high cost and the non-specificity of conventional techniques, bioremediation is a promising alternative technology for pollutant clean-up. Advances in bioremediation harness molecular, genetic, microbiology, and protein engineering tools and rely on identification of novel metal-sequestering peptides, rational and irrational pathway engineering, and enzyme design. Recent advances have been made for enhanced inorganic chemical remediation and organic chemical degradation using various pathway-engineering approaches and these are discussed in this review.
authors.affiliation: Department of Chemical and Environmental Engineering, University of California, Riverside, CA 92521, USA.
authors.forename: Shailendra
authors.initials: S
authors.lastname: Singh
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Kang
authors.forename: Ashok
authors.initials: A
authors.lastname: Mulchandani
authors.forename: Wilfred
authors.initials: W
authors.lastname: Chen