title: BCL11B is a general transcriptional repressor of the HIV-1 long terminal repeat in T lymphocytes through recruitment of the NuRD complex.
abstract: In this study we provide evidence that the transcription factor BCL11B represses expression from the HIV-1 long terminal repeat (LTR) in T lymphocytes through direct association with the HIV-1 LTR. We also demonstrate that the NuRD corepressor complex mediates BCL11B transcriptional repression of the HIV-1 LTR. In addition, BCL11B and the NuRD complex repressed TAT-mediated transactivation of the HIV-1 LTR in T lymphocytes, pointing to a potential role in initiation of silencing. In support of all the above results, we demonstrate that BCL11B affects HIV-1 replication and virus production, most likely by blocking LTR transcriptional activity. BCL11B showed specific repression for the HIV-1 LTR sequences isolated from seven different HIV-1 subtypes, demonstrating that it is a general transcriptional repressor for all LTRs.
authors.affiliation: Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue MC-165, Albany, NY 12208, USA.
authors.forename: Valeriu B
authors.initials: VB
authors.lastname: Cismasiu
authors.forename: Elena
authors.initials: E
authors.lastname: Paskaleva
authors.forename: Sneha
authors.initials: S
authors.lastname: Suman Daya
authors.forename: Mario
authors.initials: M
authors.lastname: Canki
authors.forename: Karen
authors.initials: K
authors.lastname: Duus
authors.forename: Dorina
authors.initials: D
authors.lastname: Avram