Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis.
The Pd-catalysed asymmetric intramolecular alpha-arylation of amide enolates containing heteroatom substituents gives chiral 3-alkoxy or 3-aminooxindoles in high yield and with enantioselectivities up to 97% ee when a new chiral N-heterocyclic carbene ligand is used.
Jia
Yi-Xia
YX
Department of Organic Chemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211, Genea 4, Switzerland.
Hillgren
J Mikael
JM
Watson
Emma L
EL
Marsden
Stephen P
SP
Kündig
E Peter
EP