Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.
We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.
Sun
Jielin
J
Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Zheng
Siqun Lilly
SL
Wiklund
Fredrik
F
Isaacs
Sarah D
SD
Purcell
Lina D
LD
Gao
Zhengrong
Z
Hsu
Fang-Chi
FC
Kim
Seong-Tae
ST
Liu
Wennuan
W
Zhu
Yi
Y
Stattin
Pär
P
Adami
Hans-Olov
HO
Wiley
Kathleen E
KE
Dimitrov
Latchezar
L
Sun
Jishan
J
Li
Tao
T
Turner
Aubrey R
AR
Adams
Tamara S
TS
Adolfsson
Jan
J
Johansson
Jan-Erik
JE
Lowey
James
J
Trock
Bruce J
BJ
Partin
Alan W
AW
Walsh
Patrick C
PC
Trent
Jeffrey M
JM
Duggan
David
D
Carpten
John
J
Chang
Bao-Li
BL
Grönberg
Henrik
H
Isaacs
William B
WB
Xu
Jianfeng
J