title: Delivery of insulin to the buccal mucosa utilizing the RapidMist system.
abstract: BACKGROUND
  The burgeoning number of people with diabetes mellitus is a global problem. Simple but effective treatment with minimal side effects will be required to reduce the risk for macro- and micro-vascular complications. A big part of this goal can be achieved by the ready administration of insulin with or without other medications.
  
  
  METHODS
  The RapidMist drug delivery system places human recombinant insulin in a liquid formulation so as to be delivered to the buccal mucosa with an asthma-like device. As with nitroglycerin, the insulin PK-PD is very fast, thus affording flexibility.
  
  
  CONCLUSIONS
  Serial data show clinical efficacy in Type 1 and Type 2 diabetes with at least non-inferiority to regular insulin.
authors.affiliation: Albert Einstein College of Medicine, 48 Carleon Avenue, Larchmont, NY 10538, USA. Pastafajer@aol.com
authors.forename: Gerald
authors.initials: G
authors.lastname: Bernstein