Convenient syntheses of homopropargylglycine.
An improved classic Strecker synthesis was elaborated leading to racemic homopropargylglycine (Hpg) in 61% overall yield, while an asymmetric Strecker reaction produced Hpg and the higher homolog 2-aminohept-6-ynoic acid in significantly higher yields and over 80% ee.
Dong
Shouliang
S
Max-Planck-Institut für Biochemie, Am Klopferspitz 18, D-82152 Martinsried, Germany.
Merkel
Lars
L
Moroder
Luis
L
Budisa
Nediljko
N