title: G--C quartet--a DNA-inspired Janus-GC heterocycle: synthesis, structural analysis, and self-organization.
abstract: In this communication we disclose the synthesis and characterization of a DNA-inspired self-complementary heterocycle that contains AAD-DAA H-bond acceptor/donor patterns. Whereas in the past such AAD-DAA self-complementarity has given rise to trimeric and hexameric rosettes, we now demonstrate that the same H-bonding scheme, when properly arrayed, can be used to program a tetrameric rosette, which unlike a G-quartet requires no metal binding or peripheral components for preorganization. Of note, we exploit both 2D-NOESY and DOSY 1H NMR to substantiate the tetrameric stoichiometry in this noncovalent rosette comprising 12 H-bonds.
authors.affiliation: Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, B.C., V6T-1Z1, Canada.
authors.forename: Ali
authors.initials: A
authors.lastname: Asadi
authors.forename: Brian O
authors.initials: BO
authors.lastname: Patrick
authors.forename: David M
authors.initials: DM
authors.lastname: Perrin