title: Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.
abstract: We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.
authors.affiliation: Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
authors.forename: Jielin
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authors.lastname: Grönberg
authors.forename: William B
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authors.lastname: Isaacs
authors.forename: Jianfeng
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authors.lastname: Xu