The influence of Annexin32, a new Ca(2+)-dependent phospholipid-binding protein, on coagulation time and thrombosis.
The pharmacodynamics of Annexin32, a new Ca(2+)-dependent phospholipid-binding protein, was studied by measuring coagulation time in rabbits and venous thrombosis in rabbits and rats. Rabbits and rats were given Annexin32 by intravenous administration. Then Kaolin partial thromboplastin time (KPTT), thrombosis in vitro and in vivo were assayed. The results showed that KPTT of rabbits was prolonged (p < 0.01), and the length and weight of thrombus in vitro were reduced (p < 0.01) after administration of Annexin32 at 1 mg/kg. It also inhibited thrombosis in vivo and reduced the weight of venous thrombus significantly in rats (p < 0.01). All these results suggested that Annexin32 possesses the characteristic of antithrombotic effect and fewer side effects on coagulation time.
Zhang
Yi
Y
Department of Medical Genetics, Institute of Medical Biotechnology & Molecular Genetics, Second Military Medical University, 200433, Shanghai, China.
Chen
Ruiwen
R
Sun
Shuhan
S