title: Reliability and reproducibility of N-[11C]methyl-choline and L-(S-methyl-[11C])methionine solid-phase synthesis: a useful and suitable method in clinical practice.
abstract: OBJECTIVE
  N-[11C]methyl-choline ([11C]choline) and L-(S-methyl-[11C])methionine ([11C]methionine) are PET radiopharmaceuticals which have gained interest as oncological tracers. The increasing demand of these radiopharmaceuticals needs robust methods of synthesis with high and reproducible yield which provide enough activity for multiple patient administration in a short synthesis time.
  
  
  METHODS
  Different synthetic approaches have been described in the literature but exhaustive reports on performance and reliability of different methods have not been described yet.
  
  
  CONCLUSIONS
  In the present study, we demonstrated the reliability and reproducibility of the solid-phase [11C]methylation method for the synthesis of [11C]choline and [11C]methionine as a suitable tool for the routine clinical use.
authors.affiliation: Nuclear Medicine Unit, Medical Physics Department, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Lodi
authors.forename: Anna
authors.initials: A
authors.lastname: Rizzello
authors.forename: Silvia
authors.initials: S
authors.lastname: Trespidi
authors.forename: Donato
authors.initials: D
authors.lastname: Di Pierro
authors.forename: Mario
authors.initials: M
authors.lastname: Marengo
authors.forename: Mohsen
authors.initials: M
authors.lastname: Farsad
authors.forename: Stefano
authors.initials: S
authors.lastname: Fanti
authors.forename: Adil
authors.initials: A
authors.lastname: Al-Nahhas
authors.forename: Domenico
authors.initials: D
authors.lastname: Rubello
authors.forename: Stefano
authors.initials: S
authors.lastname: Boschi