Mechanistic insights from reversible splicing catalysis.
Recent work demonstrating the ability of spliceosomes purified after the second catalytic step of splicing to efficiently reverse both steps of the reaction provides answers to several unresolved questions regarding the splicing reaction, and raises many more.
Smith
Duncan J
DJ
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. dsmith@mail.rockefeller.edu
Konarska
Maria M
MM