[Efficacy of therapy of different variants of anaplastic large T-cell lymphomas].
OBJECTIVE
To compare efficacy of NHL-BFM-90 and CHOP-like courses in the treatment of anaplastic large cell lymphoma (ALCL).


METHODS
Twenty-two patients with ALCL participated in the study. The diagnosis was made basing on the findings of clinical, device, morphological, immunohistochemical and molecular-genetic examinations with application of a panel of monoclonal antibodies to CD30, ALK, CD3, CD4, CDS, CD7, CD34, CD15, CD68, CD20, CD45RO, CD45RA, Ki-67. 14 cases of 22 were negative by kinase of anaplastic lymphocytes (ALK-) and 8 were positive (ALK+). Mean age of ALK-ALCL patients was 39.6 +/- 4.1 years, of ALK+ALCL patients - 23.4 +/- 2.6 years. 14 patients were treated by the protocol NHL-BFM-90, 8 were initially treated with other schemes (CHOP, MACOP-B, BEACOPP and others). All 14 patients treated according to NHL-BFM-90 had ALCL stages III-IV with B-symptoms. 12 patients who completed treatment by the above protocol achieved complete remission after the forth course, 2 patients failed the treatment. Of 8 ALCL patients treated initially according to other schemes, a complete remission was achieved in 4 patients (2 had stage II). One of 4 patients with remission had recurrence. Four patients who had failed to achieve complete remission died of the disease progression.


CONCLUSIONS
ALCL occurs more frequently in young and middle-aged patients. The disease has an aggressive course with rapid generalization. For such processes it is more preferable to use a modified protocol NHL-BFM-90.
Vinogradova
Iu E
IuE
Lutsenko
I N
IN
Kaplanskaia
I B
IB
Vorob'ev
I A
IA
Samoĭlova
R S
RS
Gorgidze
L A
LA
Ryzhikova
N A
NA
Valiev
T T
TT
Giliazitdinova
E A
EA
Dzhulakian
U L
UL
Egorova
E K
EK
Zvonkov
E E
EE
Krasil'nikova
B B
BB
Magomedova
A U
AU
Margolin
O V
OV
Mar'in
D S
DS
Kremenetskaia
A M
AM
Kravchenko
S K
SK
Vorob'ev
A I
AI