The effectiveness of glucocorticoids in treating croup: meta-analysis.
OBJECTIVE
To determine the effectiveness of glucocorticoid treatment in children with croup.


METHODS
Meta-analysis of randomized controlled trials that examine the effectiveness of glucocorticoid treatment in children with croup.


METHODS
Score on scale measuring severity of croup,use of co-interventions (epinephrine, antibiotics, or supplemental glucocorticoids), length of stay in the emergency department or the hospital, and rate of hospitalization.


RESULTS
Twenty-four studies met the inclusion criteria. Glucocorticoid treatment was associated with an improvement in the croup severity score at 6 hours with an effect size of -1.0 (95% confidence interval [CI] -1.5 to -0.6) and at 12 hours -1.0 (-1.6 to -0.4); at 24 hours, this improvement was no longer significant (-1.0, -2.0 to -0.1). There was a decrease in the number of epinephrine treatments needed in children treated with glucocorticoids: a decrease of 9% (95% CI 2% to 16%) among those treated with budesonide and of 12% (4% to 20%) among those treated with dexamethasone. There was also a decrease in the length of time spent in the emergency department (-11 hours, 95% CI -18 to 4 hours) and, for inpatients, hospital stay was reduced by 16 hours (-31 to 1 hour). Publication bias seems to play a part in these results.


CONCLUSIONS
Dexamethasone and budesonide are effective in relieving the symptoms of croup as early as 6 hours after treatment. Fewer co-interventions are used, and the length of time spent in the hospital is decreased in patients treated withglucocorticoids.
Ausejo
M
M
Center for Systematic Reviews, CHEO Research Institute, 401 Smyth Road, Ottowa, Ontario, Canada KIH 8L1.
Saenz
A
A
Pham
B
B
Moher
D
D
Chalmers
T C
TC
Kellner
J D
JD
Johnson
D W
DW
Klassen
T P
TP