Cyclic imine nitro-Mannich/lactamization cascades: a direct stereoselective synthesis of multicyclic piperidinone derivatives.
An efficient nitro-Mannich/lactamization cascade of gamma-nitro esters with cyclic imines for the preparation of architecturally complex multicyclic piperidinone ring-containing structures has been developed. The reaction is broad in scope and stereoselective and may be coupled to an enantioselective nitroolefin Michael addition reaction as part of a highly enantio- and diastereoselective multicomponent process.
Jakubec
Pavol
P
School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Helliwell
Madeleine
M
Dixon
Darren J
DJ