title: Junceols D-H, new polyoxygenated briaranes from sea whip gorgonian coral Junceella juncea (Ellisellidae).
abstract: Chemical investigations on the sea whip gorgonian coral Junceella juncea have led to the isolation of five new 8-hydroxybriarane diterpenoids, junceols D-H (1-5). The structures of briaranes 1-5 were determined on the basis of spectroscopic methods and the methylenecyclohexane rings were found to exist in boat form in these new diterpenoids. Junceols D (1) and F-H (3-5) exhibited cytotoxicity toward CCRF-CEM and DLD-1 tumor cells and junceols E-H (2-5) displayed weak inhibitory effects on superoxide anion generation by human neutrophils.
authors.affiliation: Taiwan Coral Research Center (TCRC), National Museum of Marine Biology & Aquarium (NMMBA), Checheng, Pingtung, Taiwan. pjsung@nmmba.gov.tw
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.forename: Chen-Hao
authors.initials: CH
authors.lastname: Pai
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Tung-Yung
authors.initials: TY
authors.lastname: Fan
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Lee-Shing
authors.initials: LS
authors.lastname: Fang
authors.forename: Wei-Hsien
authors.initials: WH
authors.lastname: Wang
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu