title: Modulation of host genes by mammalian transposable elements.
abstract: Interspersed repetitive sequences are major components of eukaryotic genomes. They comprise about 50% of the mammalian genome. They interact with the whole genome and influence its evolution. They do this in many ways, e.g. by serving as recombination hotspots, providing a mechanism for genomic shuffling and a source of 'ready-to-use' motifs for new transcriptional regulatory elements, polyadenylation signals, and protein-coding sequences. In this review we discuss the consequences of exaptation of sequences originated in tansposable elements with focus on events that influence protein coding genes.
authors.affiliation: Institute of Molecular Evolutionary Genetics and Department of Biology, The Pennsylvania State University, University Park, Ill. USA.
authors.forename: W
authors.initials: W
authors.lastname: Maka Owski
authors.forename: Y
authors.initials: Y
authors.lastname: Toda