[Principles of therapeutic drug monitoring].
Requesting a blood level measurement of a drug is part of the global approach known as "Therapeutic Drug Monitoring". Diverse situations require this monitoring approach, such as inadequate response to treatment or organ failure. Every drug however does not possess all the characteristics for a TDM program. The therapeutic range of a TDM drug has indeed to be narrow and its interindividual pharmacokinetic variability to be wide. As the development of new drugs is currently slowing down, the precise management of existing treatments certainly deserves progress, but needs however to be applied rationally, starting from a valid indication to blood sampling, and ending with a sound dosage adaptation decision.
Widmer
Nicolas
N
Division de pharmacologie et toxicologie cliniques, CHUV et Université de Lausanne.
Csajka
Chantal
C
Werner
Dominique
D
Grouzmann
Eric
E
Decosterd
Laurent A
LA
Eap
Chin B
CB
Biollaz
Jérôme
J
Buclin
Thierry
T