title: Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy.
abstract: The signal-intensity loss from anomalous J-modulation effects due to chemical-shift displacement was investigated on amino acid groups (alanine, valine, leucine, and isoleucine) at 3T by using point-resolved (1)H spectroscopy in patients with brain abscess and phantom experiments. With a larger chemical shift between methyl and methine resonances, alanine shows a greater effect of signal-intensity cancellation compared with other amino acids around 0.9 ppm, resulting in noninverted doublets at a TE of 144 ms.
authors.affiliation: Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan.
authors.forename: H-S
authors.initials: HS
authors.lastname: Liu
authors.forename: H-W
authors.initials: HW
authors.lastname: Chung
authors.forename: C-J
authors.initials: CJ
authors.lastname: Juan
authors.forename: S-Y
authors.initials: SY
authors.lastname: Tsai
authors.forename: C-Y
authors.initials: CY
authors.lastname: Wang
authors.forename: C-C
authors.initials: CC
authors.lastname: Chan
authors.forename: G-S
authors.initials: GS
authors.lastname: Huang
authors.forename: M-C
authors.initials: MC
authors.lastname: Chou
authors.forename: C-S
authors.initials: CS
authors.lastname: Lee
authors.forename: C-W
authors.initials: CW
authors.lastname: Ko
authors.forename: N-Y
authors.initials: NY
authors.lastname: Cho
authors.forename: C-Y
authors.initials: CY
authors.lastname: Chen