Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy.
The signal-intensity loss from anomalous J-modulation effects due to chemical-shift displacement was investigated on amino acid groups (alanine, valine, leucine, and isoleucine) at 3T by using point-resolved (1)H spectroscopy in patients with brain abscess and phantom experiments. With a larger chemical shift between methyl and methine resonances, alanine shows a greater effect of signal-intensity cancellation compared with other amino acids around 0.9 ppm, resulting in noninverted doublets at a TE of 144 ms.
Liu
H-S
HS
Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan.
Chung
H-W
HW
Juan
C-J
CJ
Tsai
S-Y
SY
Wang
C-Y
CY
Chan
C-C
CC
Huang
G-S
GS
Chou
M-C
MC
Lee
C-S
CS
Ko
C-W
CW
Cho
N-Y
NY
Chen
C-Y
CY