title: [Quality control of prenatal screening].
abstract: BACKGROUND
  In 2004 the Danish National Board of Health (DNBH) published new guidelines for the prenatal risk assessment and diagnostic service. The new guidelines are nationally implemented. DNBH has pointed out the importance of quality control, but has not given any specific guidelines concerning this. We demonstrate the feasibility of a quality assessment of a considerable part of the screening programme.
  
  
  METHODS
  The quality assessment is conducted on a cohort from Holbaek Hospital during 12 months by merging data from one local hospital database to data from the Danish Cytogenetic Centralregistry and the Danish National Newborn Screening Registry.
  
  
  RESULTS
  The study included 1796 singleton pregnancies and 47 twin pregnancies. 46 invasive procedures were carried out among the singleton pregnancies, which corresponds to an invasive rate of 2.6%. Two fetuses with Down's syndrome (DS) and one with trisomy 18 were found and the pregnancies were terminated. One fetus with Turners syndrome was diagnosed prenatally, but ended as a missed abortion. One child with DS was not diagnosed prenatally. The detection rate for DS was 2/3 (67%).
  
  
  CONCLUSIONS
  We suggest that the outlined quality program is implemented as a national programme.
authors.affiliation: Statens Serum Institut, Klinisk Biokemisk Afdeling, København S. kasper_pihl@dadlnet.dk
authors.forename: Kasper
authors.initials: K
authors.lastname: Pihl
authors.forename: Torben
authors.initials: T
authors.lastname: Larsen
authors.forename: Lasse
authors.initials: L
authors.lastname: Jønsson
authors.forename: David
authors.initials: D
authors.lastname: Hougaard
authors.forename: Lone
authors.initials: L
authors.lastname: Krebs
authors.forename: Bent
authors.initials: B
authors.lastname: Nørgaard-Pedersen
authors.forename: Michael
authors.initials: M
authors.lastname: Christiansen