title: Estimating number of clusters based on a general similarity matrix with application to microarray data.
abstract: Many clustering methods require that the number of clusters believed present in a given data set be specified a priori, and a number of methods for estimating the number of clusters have been developed. However, the selection of the number of clusters is well recognized as a difficult and open problem and there is a need for methods which can shed light on specific aspects of the data. This paper adopts a model for clustering based on a specific structure for a similarity matrix. Publicly available gene expression data sets are analyzed to illustrate the method and the performance of our method is assessed by simulation.
authors.affiliation: University of Toronto. shafagh@utstat.toronto.edu
authors.forename: Shafagh
authors.initials: S
authors.lastname: Fallah
authors.forename: David
authors.initials: D
authors.lastname: Tritchler
authors.forename: Joseph
authors.initials: J
authors.lastname: Beyene