title: Cationic metal-corrole complexes: design, synthesis, and properties of guanine-quadruplex stabilizers.
abstract: A series of pyridinium and quaternary ammonium copper corroles has been designed and synthesized. All new compounds have been fully characterized by NMR spectroscopy, high-resolution mass spectrometry, UV/Vis spectrscopy, and elemental analysis. Biochemical studies have indicated that all of these corrole derivatives can stabilize G-quadruplex structures, with corrole 4 being the most effective according to the results of circular dichroism (CD) melting experiments, polymerase chain reaction (PCR) stop assays, and surface plasmon resonance (SPR) experiments. Moreover, both corroles 3 and 4 tend to induce the human telomeric sequence to form hybrid G-quadruplex structures, whereas corroles 8 and 9 are more inclined to induce the human telomeric sequence to form antiparallel G-quadruplex structures.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, China.
authors.forename: Boqiao
authors.initials: B
authors.lastname: Fu
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Xiaocheng
authors.initials: X
authors.lastname: Weng
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.forename: Heng
authors.initials: H
authors.lastname: Ma
authors.forename: Yuzhi
authors.initials: Y
authors.lastname: Ma
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou