Preferential protection against Marek's disease pathogenesis by immunisation with syngeneic virus-nonproducer lymphoblastoid cells.
The effect of immunisation with virus non-producer Marek's disease (MD) lymphoma-derived lymphoblastoid cells on virus replication and lymphoid organ pathogenesis following MD virus challenge was studied with chickens from two related inbred lines and their F(1 )offspring. Protection against peripheral blood lymphocyte-associated viraemia as well as MD virus-caused weight changes of the spleen and bursa of Fabricius and degenerative bursal lesions was significantly greater among syngeneic and semi-syngeneic (F(1)) recipients than among allogeneic recipients of the lymphoblastoid cells. The results suggest that the protective immunity observed may be major histocompatibility complex (MHC) antigen-restricted and that non-infectious MD virus-transformed cells possess antigens that can induce anti-viral immunity.
Tseng
C K
CK
Department of Avian Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Fletcher
O J
OJ
Schierman
L W
LW