Nonracemic diarylmethanols from CuH-catalyzed hydrosilylation of diaryl ketones.
An efficient method for the synthesis of nonracemic diarylmethanols has been developed. The use of ( R)-(-)-(DTBM-SEGPHOS)CuH effects highly enantioselective 1,2-hydrosilylation of prochiral diaryl ketones.
Lee
Ching-Tien
CT
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.
Lipshutz
Bruce H
BH