Cellular automata approach of transmembrane ionic currents.
Ionic currents across neuron and glial cells membranes lie at the origin of the entire brain electrophysiology. They are the common root of functional brain dynamics and mesoscopic or macroscopic phenomena such as extracellular fields. In particular, they provide the relevant basis to relate cellular electrophysiology and macroscopic dipole models. In order to derive robust features and to envision the multi-scale approaches required to connect the different levels of observation, an essential prerequisite is to have minimal model of elementary ionic motions. In this paper, we propose a general cellular automata framework allowing to investigate the distribution of ionic currents in heterogeneous media interspersed with membranes, from which follows the local electromagnetic field.
Pezard
Laurent
L
Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6149, Université de Provence - Marseille Cedex 3, France. laurent.pezard@univ-provence.fr
Lesne
Annick
A