title: Diversity oriented microwave-assisted synthesis of (-)-steganacin aza-analogues.
abstract: A novel microwave-assisted, highly efficient protocol for the synthesis of hitherto unknown aza-analogues of (-)-Steganacin, a naturally occurring bisbenzocyclooctadiene lignan lactone with potent antileukemic and tubulin polymerization inhibitory activity, has been developed. Focused microwave irradiation is demonstrated to be highly beneficial in promoting the three crucial steps of the sequence to effect the final ring closure: the Suzuki-Miyaura reaction, Cu-mediated A3-coupling, as well as the intramolecular Huisgen 1,3-dipolar cycloaddition.
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001, Heverlee, Leuven, Belgium.
authors.forename: Nuria
authors.initials: N
authors.lastname: Mont
authors.forename: Vaibhav Pravinchandra
authors.initials: VP
authors.lastname: Mehta
authors.forename: Prasad
authors.initials: P
authors.lastname: Appukkuttan
authors.forename: Tetyana
authors.initials: T
authors.lastname: Beryozkina
authors.forename: Suzzane
authors.initials: S
authors.lastname: Toppet
authors.forename: Kristof
authors.initials: K
authors.lastname: Van Hecke
authors.forename: Luc
authors.initials: L
authors.lastname: Van Meervelt
authors.forename: Arnout
authors.initials: A
authors.lastname: Voet
authors.forename: Marc
authors.initials: M
authors.lastname: DeMaeyer
authors.forename: Erik
authors.initials: E
authors.lastname: Van der Eycken