title: Etiology, prenatal diagnostics and outcome of ventriculomegaly in 230 cases.
abstract: OBJECTIVE
  The aim of this study was to review and summarize the information regarding the etiology, diagnostics and outcome of ventriculomegaly.
  
  
  METHODS
  The study included 230 cases of ventriculomegaly examined between 1979 and 2000. The main diagnostic criterion for ventriculomegaly was the transverse diameter of the ventricular atrium at the level of the glomus of the chorioid plexus measuring >10 mm, irrespective of gestational age.
  
  
  RESULTS
  Gender distribution (male:female ratio: 0.98) coincided with that of the general population. In 32% of the cases (72/230), the history was positive; 6% (12/230) had a positive genetic history, while 26% (60/230) were associated with pathological obstetric events. The incidence rate of ventriculomegaly in the patients' history was found to be 2.61% (6/230). In nearly 60% of the cases included in this study, ventriculomegaly was diagnosed before the 24th week of pregnancy. Fresh fetal infection confirmed by Toxoplasma PCR real-time examination was diagnosed only in cases of severe ventriculomegaly. Based on the measurement of the diameter of the atrium of the lateral ventricle, severe and mild ventriculomegaly was diagnosed in 142/230 (61.7%) and 88/230 cases (38.3%), respectively. Termination of pregnancy was significantly more frequent in cases of severe than of mild ventriculomegaly (92 vs. 66%).
  
  
  CONCLUSIONS
  The importance of positive obstetric and/or genetic history should be emphasized as it is in direct relationship with the increased incidence of this malformation. Regarding the practice of ultrasonography, mild ventriculomegaly (transverse diameter of the lateral ventricle <15 mm) has a much better prognosis than the severe form (transverse diameter of the lateral ventricle >15 mm) of the malformation. Based on the ultrasonographic diagnosis of ventriculomegaly, TORCH serological examination is also recommended since treating toxoplasmosis by medication may have a promising prognosis for the pregnancy. In cases of isolated ventriculomegaly alone, intrauterine karyotyping is not necessarily indicated, but in cases where ventriculomegaly is associated with other genetic disorders karyotyping should definitely be performed. Since ventriculomegaly is not incompatible with postnatal life by itself, the decision about the fate of the pregnancy is largely dependent on the presence of other organic disorders.
authors.affiliation: 1st Department of Obstetrics and Gynecology, Semmelweis University Medical School, Budapest, Hungary.
authors.forename: József Gábor
authors.initials: JG
authors.lastname: Joó
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Tóth
authors.forename: Artúr
authors.initials: A
authors.lastname: Beke
authors.forename: Csaba
authors.initials: C
authors.lastname: Papp
authors.forename: Erno
authors.initials: E
authors.lastname: Tóth-Pál
authors.forename: Akos
authors.initials: A
authors.lastname: Csaba
authors.forename: Zsanett
authors.initials: Z
authors.lastname: Szigeti
authors.forename: Attila
authors.initials: A
authors.lastname: Rab
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Papp