Live cell surface labeling with fluorescent Ag nanocluster conjugates.
DNA-encapsulated silver clusters are readily conjugated to proteins and serve as alternatives to organic dyes and semiconductor quantum dots. Stable and bright on the bulk and single molecule levels, Ag nanocluster fluorescence is readily observed when staining live cell surfaces. Being significantly brighter and more photostable than organics and much smaller than quantum dots with a single point of attachment, these nanomaterials offer promising new approaches for bulk and single molecule biolabeling.
Yu
Junhua
J
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
Choi
Sungmoon
S
Richards
Chris I
CI
Antoku
Yasuko
Y
Dickson
Robert M
RM