title: Cetuximab with hepatic arterial infusion of chemotherapy for the treatment of colorectal cancer liver metastases.
abstract: BACKGROUND
  Both hepatic arterial infusion (HAI) of chemotherapy and cetuximab (CET) have interesting activity for the treatment of colorectal cancer liver metastases (CRC-LM).
  
  
  METHODS
  Intravenous CET with HAI oxaliplatin (OXA) or i.v. Irinotecan (IRI) followed by HAI of infusion of folic acid modulated 5-fluorouracil 5-FU/l-FA was administered to patients (pts) with CRC-LM who had failed at least one line of prior chemotherapy.
  
  
  RESULTS
  Eight pts received i.v. CET with HAI-OXA (5 pts) and i.v.-IRI (3 pts) and HAI-5-FU/l-FA. Adverse events: repeated grade 3 skin toxicity (1 pt), abdominal pain with elevated liver enzymes and asthenia (2 pts), duodenal ulcer (2 pts) with catheter migration and intestinal bleeding (1 pt), reversible interstitial pneumonitis (1 pt), and cystic bile duct dilatation (2 pts) with arteriobiliary fistulisation (1 pt). A partial response was documented in 5 pts (62%). The median time to progression was 8.7 months (95% confidence interval 8-14 months).
  
  
  CONCLUSIONS
  Intravenous administration of CET with HAI of chemotherapy is feasible and has promising activity but is associated with specific toxicity.
authors.affiliation: Medical Oncology, UZ Brussel, Brussels, Belgium. Bart.Neyns@uzbrussel.be
authors.forename: Bart
authors.initials: B
authors.lastname: Neyns
authors.forename: Maridi
authors.initials: M
authors.lastname: Aerts
authors.forename: Yves
authors.initials: Y
authors.lastname: Van Nieuwenhove
authors.forename: Christel
authors.initials: C
authors.lastname: Fontaine
authors.forename: Lore
authors.initials: L
authors.lastname: De Coster
authors.forename: Dennis
authors.initials: D
authors.lastname: Schallier
authors.forename: Jacques
authors.initials: J
authors.lastname: Vanderauwera
authors.forename: Floris
authors.initials: F
authors.lastname: De Munck
authors.forename: Frederik
authors.initials: F
authors.lastname: Vandenbroucke
authors.forename: Hendrik
authors.initials: H
authors.lastname: Everaert
authors.forename: Vanessa
authors.initials: V
authors.lastname: Meert
authors.forename: Johan
authors.initials: J
authors.lastname: De Mey
authors.forename: Mark
authors.initials: M
authors.lastname: De Ridder
authors.forename: Georges
authors.initials: G
authors.lastname: Delvaux
authors.forename: Jacques
authors.initials: J
authors.lastname: De Grève