Reliability and reproducibility of N-[11C]methyl-choline and L-(S-methyl-[11C])methionine solid-phase synthesis: a useful and suitable method in clinical practice.
OBJECTIVE
N-[11C]methyl-choline ([11C]choline) and L-(S-methyl-[11C])methionine ([11C]methionine) are PET radiopharmaceuticals which have gained interest as oncological tracers. The increasing demand of these radiopharmaceuticals needs robust methods of synthesis with high and reproducible yield which provide enough activity for multiple patient administration in a short synthesis time.


METHODS
Different synthetic approaches have been described in the literature but exhaustive reports on performance and reliability of different methods have not been described yet.


CONCLUSIONS
In the present study, we demonstrated the reliability and reproducibility of the solid-phase [11C]methylation method for the synthesis of [11C]choline and [11C]methionine as a suitable tool for the routine clinical use.
Lodi
Filippo
F
Nuclear Medicine Unit, Medical Physics Department, S. Orsola-Malpighi Hospital, Bologna, Italy.
Rizzello
Anna
A
Trespidi
Silvia
S
Di Pierro
Donato
D
Marengo
Mario
M
Farsad
Mohsen
M
Fanti
Stefano
S
Al-Nahhas
Adil
A
Rubello
Domenico
D
Boschi
Stefano
S