Prognostic factors and survival analysis in a sample of oral squamous cell carcinoma patients.
OBJECTIVE
The aims of this report were to describe the 5-year overall survival (OS) in a group of oral squamous cell carcinoma (OSCC) patients and to investigate the effects of age, gender, anatomic localization, tumor evolution time, smoking and alcohol intake, nodal status, tumoral recurrences, histologic classification, p53 and p63 immunoexpression, human papillomavirus DNA presence, and treatment on the prognostic outcome.


METHODS
Survival curves were generated using Kaplan-Meier method, and univariate and multivariate analyses were made using the log rank test and Cox regression, respectively.


RESULTS
The 5-year OS was 28.6%, and the univariate analysis showed significant results for p53 and p63 immunoexpression, age, and anatomic localization. The Cox regression demonstrated poor OS for tumors with p53 immunoexpression and for patients aged over 60 years. There were also significant differences in survival depending on the anatomic localizations.


CONCLUSIONS
These results highlight the influence of p53 immunoexpression, age, and anatomic localization in OSCC evolution.
Oliveira
Lucinei Roberto
LR
Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil. lucinei@yahoo.com
Ribeiro-Silva
Alfredo
A
Costa
João Paulo Oliveira
JP
Simões
Aguinaldo Luiz
AL
Matteo
Miguel Angel Sala Di
MA
Zucoloto
Sergio
S