title: Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge.
abstract: A structure-activity relationship (SAR) study of bastadin 6 (1), a brominated tyrosine-derived metabolite from Indonesian marine sponge having a potent anti-angiogenic activity, was executed. The syntheses and their biological evaluation of the oxime-modified analogues and bromine-modified analogues revealed that both the oxime moieties and bromine atoms in bastadin 6 (1) play an important role to show the potent and selective anti-proliferative activity against human umbilical vein endothelial cells (HUVECs).
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kotoku
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hiramatsu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tsujita
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hirakawa
authors.forename: Mami
authors.initials: M
authors.lastname: Sanagawa
authors.forename: Shunji
authors.initials: S
authors.lastname: Aoki
authors.forename: Motomasa
authors.initials: M
authors.lastname: Kobayashi