title: Inhibition of growth and induction of differentiation of colon cancer cells by peach and plum phenolic compounds.
abstract: The action of extracts from anthocyanin-enriched plums and peaches on growth and differentiation was studied with human colon cancer cells. Growth inhibitory effects were observed in Caco-2, SW1116, HT29 and NCM460 cells. In Caco-2 cells but not in the other cells studied there was evidence for increased differentiation as judged by increased activity of alkaline phosphatase and dipeptidyl peptidase. A differentiating effect on Caco-2 cells was not seen with cyanidin or cyanidin-3-glucoside but the action of the fruit extracts was additive with the action of butyrate and with the MEK1/2 inhibitor U0126. Fractionation using C18 indicated activity resided within a fraction containing anthocyanins but further fractionation using LH-20 suggested that most of the activity was in a fraction containing polyphenols other than anthocyanins. It was concluded that several peach and plum phenolic molecules can influence growth and differentiation in human colon cancer cells.
authors.affiliation: Department of Biochemistry and Molecular Biology, UMDNJ - New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA. lea@umdnj.edu
authors.forename: Michael A
authors.initials: MA
authors.lastname: Lea
authors.forename: Chinwe
authors.initials: C
authors.lastname: Ibeh
authors.forename: Charles
authors.initials: C
authors.lastname: desBordes
authors.forename: Marcia
authors.initials: M
authors.lastname: Vizzotto
authors.forename: Luis
authors.initials: L
authors.lastname: Cisneros-Zevallos
authors.forename: David H
authors.initials: DH
authors.lastname: Byrne
authors.forename: William R
authors.initials: WR
authors.lastname: Okie
authors.forename: Mary P
authors.initials: MP
authors.lastname: Moyer