title: Nickel-catalyzed asymmetric cross-couplings of racemic propargylic halides with arylzinc reagents.
abstract: A stereoconvergent method for the catalytic asymmetric Negishi cross-coupling of racemic secondary propargylic halides with arylzinc reagents has been developed. Neither family of compounds has previously been shown to be a suitable partner in such coupling processes. From a practical point of view, it is noteworthy that the catalyst components (NiCl2.glyme and pybox ligand 1) are commercially available.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Sean W
authors.initials: SW
authors.lastname: Smith
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Fu