title: MR-spectroscopic findings in juvenile-onset Huntington's disease.
abstract: Seven HD gene positive individuals under the age of 21 years are described with clinical examination and proton-MR-spectroscopy ((1)H-MRS) profiles of the putamen. Despite clinical variability, the predominate (1)H-MRS abnormality is elevated glutamate, expressed well beyond the confines of the basal ganglia, and low striatal creatine.
authors.affiliation: Department of Neurology, VA Medical Center, Milwaukee, Wisconsin 53295, USA. nreynjr@msn.com
authors.forename: Norman C
authors.initials: NC
authors.lastname: Reynolds
authors.forename: Robert W
authors.initials: RW
authors.lastname: Prost
authors.forename: Leighton P
authors.initials: LP
authors.lastname: Mark
authors.forename: Suja A
authors.initials: SA
authors.lastname: Joseph