Inherited thrombophilia screening in Greek women with recurrent fetal loss.
OBJECTIVE
The present study was designed to determine the prevalence of factor V Leiden (FVL), prothrombin gene G20210A (PTG) and methylenetetrahydrofolate reductase (MTHFR C677T) mutations in women from South-Western Greece with recurrent fetal loss (RFL) and negative personal thromboembolic history.


METHODS
212 women with RFL and 181 women with at least two pregnancies with normal outcome and no history of pregnancy loss were investigated for the commonest thrombophilic mutations (FVL, PTG, MTHFR C677T). Comparisons between groups were performed by Pearson's chi-square test and odd ratios were calculated.


RESULTS
An abnormal genotype was detected in 49 women of the study group (23.1%) and in 41 women of the control group (22.6%).


CONCLUSIONS
Inherited thrombophilia screening is not indicated as an initial approach in Greek women with RFL and negative personal thromboembolic history.
Mougiou
A
A
Department of Internal Medicine, Division of Hematology, University of Patras, Medical School, Rion, Greece.
Androutsopoulos
G
G
Karakantza
M
M
Theodori
E
E
Decavalas
G
G
Zoumbos
N
N