title: Non-invasive coronary angiography: the clinical value of multi-slice computed tomography in the assessment of patients with prior coronary bypass surgery. Evaluating grafts and native vessels.
abstract: BACKGROUND
  Contrast enhanced multi-slice computed tomography (MSCT) is the leading modality in non-invasive coronary angiography (CTA) today. We investigated MSCT based assessment of coronary artery bypass grafts (CABG) by analyzing assets and drawbacks of CTA in order to define demands on latest technology.
  
  
  METHODS
  In a clinical setting 39 CABG patients (69.2 +/- 1.4 years; male n = 36) underwent CTA (collimation 16 x 0.75 mm, contrast medium 100 ml; 320 mAs, 120 KV). Ninety-seven CABG (61 venous, 36 arterial grafts) were evaluated. A subgroup of 18 patients underwent additional invasive coronary angiography (CA).
  
  
  RESULTS
  CTA for CABG assessment resulted in an overall sensitivity (sens.) of 100%, specificity (spec.) of 92.4% and positive and negative predictive values (PPV, NPV) of 60% and 100%, respectively. CABG anastomoses showed slightly inferior diagnostic accuracy than other CABG segments. Limitations in imaging quality caused 21% unevaluable segments of the CABG anastomoses. Evaluation of native vessel segments proximal and distal to the anastomoses resulted in a sens, spec, PPV and NPV of 57.5, 94.6, 92 and 67.3%, respectively. With 28.5% unevaluable segments, the native vessel segments showed serious limitations in imaging quality. Radiation exposure was 9.88 +/- 3.20 mSv (9.69 +/- 3.25 mSv male; 12.08 +/- 1.35 mSv female).
  
  
  CONCLUSIONS
  16-slice MSCT based CABG assessment offers sufficient diagnostic accuracy. However, focussing on the bypass anastomoses and the native revascularized coronary arteries, clinical value is limited.
authors.affiliation: Department of Cardiology, Heart and Diabetes Centre North Rhine-Westphalia, Georgstr. 11, 32545 Bad Oeynhausen, Germany.
authors.forename: Helge
authors.initials: H
authors.lastname: von Kiedrowski
authors.forename: Marcus
authors.initials: M
authors.lastname: Wiemer
authors.forename: Krista
authors.initials: K
authors.lastname: Franzke
authors.forename: Rainer
authors.initials: R
authors.lastname: Preuss
authors.forename: Bernhard
authors.initials: B
authors.lastname: Vaske
authors.forename: Thomas
authors.initials: T
authors.lastname: Butz
authors.forename: Olaf
authors.initials: O
authors.lastname: Oldenburg
authors.forename: Thomas
authors.initials: T
authors.lastname: Bitter
authors.forename: Khalid
authors.initials: K
authors.lastname: Mahmood
authors.forename: Wolfram
authors.initials: W
authors.lastname: Burchert
authors.forename: Dieter
authors.initials: D
authors.lastname: Horstkotte
authors.forename: Christoph
authors.initials: C
authors.lastname: Langer