Regulation of p53R2 and its role as potential target for cancer therapy.
p53R2, a recently discovered small subunit of human ribonucleotide reductase, is believed to play essential roles in DNA repair, mtDNA synthesis, and protection against oxidative stress. Because of the positive correlation between the level of this protein and drug sensitivity and tumor invasiveness, it constitutes a potential target for anticancer drugs as well as a diagnostic marker in cancer.
Wang
Xin
X
Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institute, Karolinska Hospital, SE-171 76 Stockholm, Sweden.
Zhenchuk
Anna
A
Wiman
Klas G
KG
Albertioni
Freidoun
F