Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones.
A novel series of bacterial topoisomerase (3-aminoquinazolinediones) inhibitors are described. The side-chain SAR against Gram-positive and Gram-negative organisms as well as DNA gyrase activity is reported.
Hutchings
Kim M
KM
Pfizer Global Research and Development, Michigan Laboratories, Ann Arbor Campus, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. kim.hutchings@astrazeneca.com
Tran
Tuan P
TP
Ellsworth
Edmund L
EL
Watson
Brian M
BM
Sanchez
Joseph P
JP
Showalter
H D
HD
Stier
Michael A
MA
Shapiro
Martin
M
Themis Joannides
E
E
Huband
Michael
M
Nguyen
Dai Q
DQ
Maiti
Samarendra
S
Li
Tingsheng
T
Tailor
Jyoti
J
Thomas
George
G
Ha
Chan
C
Singh
Rajeshwar
R