title: Increased beta activity in dystonia patients after drug-induced dopamine deficiency.
abstract: Several studies have confirmed that subthalamic and pallidal local field potential activity in the beta frequency band (13-30 Hz) is exaggerated in untreated patients with Parkinson's disease (PD) and is suppressed by dopaminergic treatment. This particular spectral pattern differs from that in patients with dystonia in whom pallidal activity is prominent at low frequencies (<12 Hz). Here we demonstrate that tetrabenazine induced monoamine depletion and dopamine blockade is associated with increased activity in the low beta band (13-20 Hz) in the internal pallidum of patients with dystonia. Beta activity was elevated in six patients treated with tetrabenazine compared to six patients in whom this drug was not used. Our findings suggest that beta activity is enhanced in the chronically dopamine-depleted and blocked state irrespective of the underlying pathology, consistent with the idea that excessive synchrony in the beta band is directly related to dopaminergic hypofunction, rather than some degenerative disease-specific attribute of Parkinson's disease.
authors.affiliation: Department of Neurology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany. andrea.kuehn@charite.de
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Kühn
authors.forename: Christof
authors.initials: C
authors.lastname: Brücke
authors.forename: Gerd-Helge
authors.initials: GH
authors.lastname: Schneider
authors.forename: Thomas
authors.initials: T
authors.lastname: Trottenberg
authors.forename: Anatol
authors.initials: A
authors.lastname: Kivi
authors.forename: Andreas
authors.initials: A
authors.lastname: Kupsch
authors.forename: H Holger
authors.initials: HH
authors.lastname: Capelle
authors.forename: Joachim K
authors.initials: JK
authors.lastname: Krauss
authors.forename: Peter
authors.initials: P
authors.lastname: Brown