Unicentric castleman disease is not clearly distinguished from multicentric type: a case report.
Castleman disease (CD) was recently classified as a unicentric hyaline vascular variant, unicentric plasma cell variant, and multicentric plasma cell variant. It is rare that unicentric CD is presented as multiple retroperitoneal lymphadenopathy. The clinical manifestations and prognosis depends on histologic type. We report an unusual case of CD with multiple retroperitoneal lymphadenopathy, which had unicentric hyaline vascular variant histologically but was clinically multicentric. The patient experienced anemia, weight loss, elevated C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome), and plasmacytosis in bone marrow without human herpesvirus-8 or HIV. After exploratory laparotomy and lymphadenectomy under presumptive diagnosis of CD, the patient's symptoms recovered, and CRP and ESR decreased. Therefore, we suggest that unicentric CD is not clearly distinguished from multicentric, the type in this report, focusing on the useful role of CRP, ESR, and positron emission tomography/computed tomography in the disease activity of CD.
Choi
Jeoung Ho
JH
Department of Internal Medicine, Eulji University College of Medicine, Seoul, South Korea.
Jo
Yun Ju
YJ
Gong
Soo Jung
SJ
Hong
Boo Whan
BW
Lee
Ho Jung
HJ
Son
Byoung Kwan
BK
Jun
Dae Won
DW
Kim
Seong Hwan
SH
Park
Young Sook
YS
Seok
Ju Won
JW