title: Clinical significance of GSTM1 and GSTT1 polymorphisms in younger patients with acute myeloid leukemia of intermediate-risk cytogenetics.
abstract: We investigated the association between GSTM1 or GSTT1 polymorphisms and clinical outcomes in 133 younger patients with AML of intermediate-risk cytogenetics. Clinical outcomes were not significantly different among the GSTM1 polymorphism genotypes, whereas cumulative incidence of relapse (CIR) was significantly lower and event-free survival (EFS) was significantly higher in patients with the GSTT1-present genotype compared with those with the GSTT1-null genotype (CIR at 5 year, 28.9% vs. 44.6%, P=0.018; EFS at 5 year, 51.4% vs. 34.1%, P=0.029). Our results suggest that GSTT1 gene polymorphism has significant clinical implications in younger patients with AML of intermediate-risk cytogenetics.
authors.affiliation: Department of Internal Medicine, Kosin University Gospel Hospital, Busan, Republic of Korea.
authors.forename: Ho Sup
authors.initials: HS
authors.lastname: Lee
authors.forename: Je-Hwan
authors.initials: JH
authors.lastname: Lee
authors.forename: Eun-Hye
authors.initials: EH
authors.lastname: Hur
authors.forename: Michael Jinpyo
authors.initials: MJ
authors.lastname: Lee
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Dae-Young
authors.initials: DY
authors.lastname: Kim
authors.forename: Se Hyung
authors.initials: SH
authors.lastname: Kim
authors.forename: Miee
authors.initials: M
authors.lastname: Seol
authors.forename: Sol-Ip
authors.initials: SI
authors.lastname: Kang
authors.forename: Seong-Gil
authors.initials: SG
authors.lastname: Ryu
authors.forename: Young-Ah
authors.initials: YA
authors.lastname: Kang
authors.forename: Young-Shin
authors.initials: YS
authors.lastname: Lee
authors.forename: Mun Jung
authors.initials: MJ
authors.lastname: Kang
authors.forename: Eul-Ju
authors.initials: EJ
authors.lastname: Seo
authors.forename: Yang Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Hyun Sook
authors.initials: HS
authors.lastname: Chi
authors.forename: Chan Jeoung
authors.initials: CJ
authors.lastname: Park
authors.forename: Seongsoo
authors.initials: S
authors.lastname: Jang
authors.forename: Sung-Cheol
authors.initials: SC
authors.lastname: Yun
authors.forename: Kyoo-Hyung
authors.initials: KH
authors.lastname: Lee