title: Erlotinib monotherapy in patients with advanced non-small cell lung cancer: an effective approach with low toxicity.
abstract: BACKGROUND
  Treatment of non-small cell lung cancer (NSCLC) with tyrosine kinase inhibitors (TKIs) of epidermal growth factor receptor (EGFR) and particularly erlotinib (Tarceva) has been a field of intense research. This retrospective study was conducted to assess the efficacy of erlotinib and its impact on survival.
  
  
  METHODS
  Patients with stage IIIB or IV, advanced or recurrent metastatic NSCLC were included in the study and were administered erlotinib 150 mg daily, at different lines of treatment.
  
  
  RESULTS
  Thirty-six patients were included in the study: 29 (81%) male, 7 (19%) female. At the time of analysis, all patients had progressed and died. Median progression-free survival (PFS) was 4 months +/- 2.43 months (range 0-8 months), whereas median overall survival (OS) was 7 months +/- 2.65 months (range 3-15 months). Patients with ECOG performance status of 0 or 1 had better OS and significantly higher PFS rates. Overall response rate was 16.7%, while the disease control rate was 81%.
  
  
  CONCLUSIONS
  Erlotinib is effective and well tolerated in pretreated patients with advanced NSCLC and a good performance status.
authors.affiliation: First Department of Medical Oncology, St. Savvas Anticancer Hospital, Athens, Greece. ardavanis@yahoo.com
authors.forename: Alexandros
authors.initials: A
authors.lastname: Ardavanis
authors.forename: Stella
authors.initials: S
authors.lastname: Koumna
authors.forename: Ioannis
authors.initials: I
authors.lastname: Fragos
authors.forename: Savvoula
authors.initials: S
authors.lastname: Malliou
authors.forename: Flora
authors.initials: F
authors.lastname: Kyriakou
authors.forename: Ioannis
authors.initials: I
authors.lastname: Mantzaris
authors.forename: Andreas
authors.initials: A
authors.lastname: Scorilas
authors.forename: Gerassimos
authors.initials: G
authors.lastname: Rigatos