title: Biological evaluation of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as inhibitors of LPS-induced TNF-alpha secretion.
abstract: This study describes the effect of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as tumor necrosis factor alpha (TNF-alpha) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-alpha secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo[1,2-c]quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo[1,2-c]quinazoline derivatives may have a potential as anti-inflammatory agents.
authors.affiliation: Departamento de Farmacia, Facultad de Química, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Gloria D
authors.initials: GD
authors.lastname: Galarce
authors.forename: Rocío E
authors.initials: RE
authors.lastname: Foncea
authors.forename: Ana M
authors.initials: AM
authors.lastname: Edwards
authors.forename: Hernán
authors.initials: H
authors.lastname: Pessoa-Mahana
authors.forename: Carlos D
authors.initials: CD
authors.lastname: Pessoa-Mahana
authors.forename: Roberto A
authors.initials: RA
authors.lastname: Ebensperger