title: New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.
abstract: A new route for the stereoselective synthesis of iodinated reboxetine analogues has been developed for the generation of SPECT imaging agents for the noradrenaline transporter (NAT). (2S,3S)- and (2R,3R)-iodoreboxetine were prepared and biological testing against various mono-amine transporters showed these compounds to be potent and selective for NAT.
authors.affiliation: WestChem, Department of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK.
authors.forename: Nicola K
authors.initials: NK
authors.lastname: Jobson
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Crawford
authors.forename: Deborah
authors.initials: D
authors.lastname: Dewar
authors.forename: Sally L
authors.initials: SL
authors.lastname: Pimlott
authors.forename: Andrew
authors.initials: A
authors.lastname: Sutherland