title: Prognostic factors and survival analysis in a sample of oral squamous cell carcinoma patients.
abstract: OBJECTIVE
  The aims of this report were to describe the 5-year overall survival (OS) in a group of oral squamous cell carcinoma (OSCC) patients and to investigate the effects of age, gender, anatomic localization, tumor evolution time, smoking and alcohol intake, nodal status, tumoral recurrences, histologic classification, p53 and p63 immunoexpression, human papillomavirus DNA presence, and treatment on the prognostic outcome.
  
  
  METHODS
  Survival curves were generated using Kaplan-Meier method, and univariate and multivariate analyses were made using the log rank test and Cox regression, respectively.
  
  
  RESULTS
  The 5-year OS was 28.6%, and the univariate analysis showed significant results for p53 and p63 immunoexpression, age, and anatomic localization. The Cox regression demonstrated poor OS for tumors with p53 immunoexpression and for patients aged over 60 years. There were also significant differences in survival depending on the anatomic localizations.
  
  
  CONCLUSIONS
  These results highlight the influence of p53 immunoexpression, age, and anatomic localization in OSCC evolution.
authors.affiliation: Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil. lucinei@yahoo.com
authors.forename: Lucinei Roberto
authors.initials: LR
authors.lastname: Oliveira
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ribeiro-Silva
authors.forename: João Paulo Oliveira
authors.initials: JP
authors.lastname: Costa
authors.forename: Aguinaldo Luiz
authors.initials: AL
authors.lastname: Simões
authors.forename: Miguel Angel Sala Di
authors.initials: MA
authors.lastname: Matteo
authors.forename: Sergio
authors.initials: S
authors.lastname: Zucoloto