Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes.
We designed and synthesized a series of novel 3,6-bicyclolide oximes, possessing linkers of varying lengths to the secondary binding site. The E isomers exhibited excellent antibacterial profiles against a broad spectrum of resistant pathogens.
Tang
Datong
D
Enanta Pharmaceuticals, Inc., 500 Arsenal Street, Watertown, MA 02472, USA. dtang@enanta.com
Gai
Yonghua
Y
Polemeropoulos
Alexander
A
Chen
Zhigang
Z
Wang
Zhe
Z
Or
Yat Sun
YS