[Isotretinoin embryopathy. Report of one case].
Retinoic acid is a widely used drug in the treatment of cystic acne. It has teratogenic effects that depend on the gestational period in which it is used. We report a seven months old female whose mother was exposed to retinoic acid in both pre-gestational and gestational periods. She had a retardation of psychomotor development and a brain MRI showed frontal atrophy and a malformation of the posterior fossa. We discuss the mechanisms of the teratogenic effects of retinoic acid.
Troncoso Sch
Mónica
M
Servicio de Neuropsiquiatría Infantil, Hospital Clínico San Borja, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Rojas H
Carla
C
Bravo C
Eduardo
E