Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion.
Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P < 0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.
Forconi
Francesco
F
Sezione Ematologia e Trapianti, Dipartimento di Medicina Clinica e Scienze Immunologiche, Università di Siena, Siena, Italy. forconif@unisi.it
Rinaldi
Andrea
A
Kwee
Ivo
I
Sozzi
Elisa
E
Raspadori
Donatella
D
Rancoita
Paola M V
PM
Scandurra
Marta
M
Rossi
Davide
D
Deambrogi
Clara
C
Capello
Daniela
D
Zucca
Emanuele
E
Marconi
Daniela
D
Bomben
Riccardo
R
Gattei
Valter
V
Lauria
Francesco
F
Gaidano
Gianluca
G
Bertoni
Francesco
F