[Therapeutic drug monitoring: clinical practice].
When requesting a blood level measurement in the context of "Therapeutic drug monitoring" (TDM), numerous aspects have to be considered in the pre-analytical and analytical area, as in the integration of associated clinical data. This review presents therapeutic classes for which a clinical benefit of TDM is established or suggested, at least in some settings. For each class of drugs, the main pharmacokinetic, pre-analytical, analytical and clinical aspects are evaluated in the scope of such a monitoring. Each step of the TDM process is important and none should be neglected. Additional clinical trials are however warranted to better establish the exact conditions of use for such a monitoring.
Widmer
Nicolas
N
Division de pharmacologie et toxicologie cliniques, CHUV et Université de Lausanne.
Werner
Dominique
D
Grouzmann
Eric
E
Eap
Chin B
CB
Marchetti
Oscar
O
Fayet
Aurélie
A
Csajka
Chantal
C
Decosterd
Laurent A
LA
Buclin
Thierry
T