title: Anti-methicillin resistant Staphylococcus aureus (MRSA) compounds isolated from Laurus nobilis.
abstract: We found that an extract from Laurus nobilis L. (Lauraceae) leaves showed antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). We purified two flavonoids as the effective compounds and identified them as kaempferol 3-O-alpha-L-(2'',4''-di-E-p-coumaroyl)-rhamnoside (C2) and kaempferol 3-O-alpha-L-(2''-Z-p-coumaroyl-4''-E-p-coumaroyl)-rhamnoside (C3). Both compounds showed strong antibacterial activity not only against MRSA but also against vancomycin-resistant enterococci (VRE). There was low or no antibacterial activity of C2 and C3 for Streptococcus pneumoniae, Pseudomonas aeruginosa and Serratia marcescens.
authors.affiliation: Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, Japan.
authors.forename: Nao
authors.initials: N
authors.lastname: Otsuka
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Liu
authors.forename: Sumiko
authors.initials: S
authors.lastname: Shiota
authors.forename: Wakano
authors.initials: W
authors.lastname: Ogawa
authors.forename: Teruo
authors.initials: T
authors.lastname: Kuroda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hatano
authors.forename: Tomofusa
authors.initials: T
authors.lastname: Tsuchiya