title: Nodal follicular helper T-cell lymphoma may present with different patterns. A case report.
abstract: We report the case of a 62-year-old patient presenting with 3 different patterns of follicular helper T-cell lymphoma. The patient initially presented with angioimmunoblastic T-cell lymphoma. A nodal relapse in the form of follicular T-cell lymphoma with a progressively transformed germinal center pattern occurred 8 years later. Two years later, this was followed by another relapse presenting as a predominantly large-cell peripheral T-cell lymphoma, unspecified. All neoplastic cells expressed CD3, CD5, and CD2, with some neoplastic cells also expressing CD7. These cells also expressed CD4, with some expressing CD10, bcl-6, CXCL13, and programmed death-1, all of which are characteristic of the normal subset of follicular T-helper cells. The immunophenotype showed a progressive increase in the proportion of cells expressing CD10, bcl-6, CXCL13, and programmed death-1 from the first to the last lymphoma. In addition, neoplastic T cells from the last biopsy sample expressed CD20.
authors.affiliation: Service d'anatomie et de cytologie pathologiques, Hôtel-Dieu, 75181 Paris Cedex 04, France. marwanqubaja@yahoo.fr
authors.forename: Marwan
authors.initials: M
authors.lastname: Qubaja
authors.forename: Josée
authors.initials: J
authors.lastname: Audouin
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Moulin
authors.forename: Thierry Jo
authors.initials: TJ
authors.lastname: Molina
authors.forename: Agnès
authors.initials: A
authors.lastname: Le Tourneau
authors.forename: Philippe
authors.initials: P
authors.lastname: Gaulard
authors.forename: Pierre
authors.initials: P
authors.lastname: Straub
authors.forename: Bruno
authors.initials: B
authors.lastname: Audhuy
authors.forename: Jacques
authors.initials: J
authors.lastname: Diebold