Rearranged lanostane triterpenoids from Abies sachalinensis (III).
To isolate more rearranged lanostane-type triterpenes from Abies sachalinensis, continuous chemical investigation of the ethyl acetate soluble fraction of the methanol extract of A. sachalinensis afforded two new rearranged lanostane-type triterpenes (1, 2). Their structures were elucidated to be 3,4-seco-4(28),7,12,24-mariesatetraen-26,23-olide-23-hydroxy-3-oic acid (1) and ethyl 3,4-seco-8(14-->13R)abeo-17,13-friedo-4(28),7,14,24-lanostatetraen-26,23-olide-23-hydroxy-3-oate (2), respectively. The structure of these compounds was determined by spectral studies, especially by two-dimensional (2D)-NMR and high-resolution (HR)-MS. Compounds 1 and 2 have a tautomeric lactone structure in the side chain.
Gao
Hui Yuan
HY
School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang City, People's Republic of China.
Wu
Li Jun
LJ
Nakane
Takahisa
T
Shirota
Osamu
O
Kuroyanagi
Masanori
M