title: Clonazepam for chemotherapy-induced nausea and vomiting (CINV).
abstract: BACKGROUND
  A 51-year-old woman experienced refractory chemotherapy-induced nausea and vomiting (CINV) in spite of extensive antiemetic therapy, including 5-HT3 antagonists, corticosteroids, dopamine antagonists and antihistamines.
  
  
  METHODS
  We administered the patient clonazepam. After taking clonazepam, the patient fully recovered from the nausea and vomiting and never experienced them again.
  
  
  CONCLUSIONS
  Clonazepam may be useful in the control of CINV. We believe that clonazepam contributed to the favorable outcome by expressing an anxiolytic and an anticonvulsant effect on myoclonus. The efficacy of clonazepam in this indication of prevention of CINV warrants further investigation.
authors.affiliation: Department of Psychiatry, Machida Municipal Hospital, Machida-shi, Tokyo, 194-0023, Japan. mi-na@pd5.so-net.ne.jp
authors.forename: Minako
authors.initials: M
authors.lastname: Koga
authors.forename: Momoe
authors.initials: M
authors.lastname: Nakadozono
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Nukariya
authors.forename: Hiroko
authors.initials: H
authors.lastname: Nogi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakayama