Successful treatment of relapsing disseminated coccidioidomycosis with cutaneous involvement with posaconazole.
A 52-year-old woman with pulmonary sarcoidosis on immunosuppressive therapy developed pulmonary infiltrates and cutaneous granulomatous abscesses after a trip to the USA in April 2005. A hyphomycete was identified, further characterized by a gene probe as Coccidioides spp. and then definitively identified as Coccidioides posadasii by polymerase chain reaction and sequencing. Antibodies towards Coccidioides spp. were detected. The infection was successfully treated with posaconazole (Noxafil), 2 x 400 mg/d.
Wollina
Uwe
U
Department of Dermatology and Allergy, Dresden-Friedrichstadt Hospital, Academic Teaching Hospital of the Technical University, Dresden Germany. wollina-uw@khdf.de
Hansel
Gesina
G
Vennewald
Irina
I
Schönlebe
Jacqueline
J
Tintelnot
Kathrin
K
Seibold
Michael
M
Kittner
Thomas
T