Anti-inflammatory effects of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) in animal models.
BACKGROUND
KHU14, an ethanolic extract of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) was tested for its anti-inflammatory effects.


METHODS
Three out of 20 herbs were found to have anti-inflammatory effects. The formulation of these herbs, i.e. KHU14 was tested for croton oil-induced ear edema, carrageenan-induced paw edema, acetic acid-induced capillary permeability, cotton pellet and delayed type hypersensitivity.


RESULTS
KHU14 exhibited anti-inflammatory effects in animal models of acute and chronic inflammation. The anti-inflammatory activity of KHU14 observed was comparable to that of celecoxib. KHU14 inhibited the production of NO and PGE2 in LPS/IFN-gamma-stimulated peritoneal macrophages, and reduced edema and the amount of infiltrated cells in animal models.


CONCLUSIONS
KHU14 exhibited anti-inflammatory effects as demonstrated in typical immunological tests for anti-inflammation in vitro and in vivo.
Kim
Kyoung Soo
KS
East-West Bone and Joint Research Center, Kyung Hee University Neo Medical Hospital, Seoul, South Korea. labrea46@yahoo.co.kr
Rhee
Hae In
HI
Park
Eun Kyung
EK
Jung
Kiwon
K
Jeon
Hyo Jin
HJ
Kim
Ji-Hong
JH
Yoo
Hunseung
H
Han
Chang-Kyun
CK
Cho
Yong-Baik
YB
Ryu
Chun Jeih
CJ
Yang
Hyung In
HI
Yoo
Myung Chul
MC