title: Adjunctive aripiprazole decreased metabolic side effects of clozapine treatment.
abstract: Clozapine is an atypical antipsychotic indicated for the treatment of refractory schizophrenia. Clozapine treatment is associated with the metabolic side effects. Weight gain, hyperlipidemia and hyperglycemia are the risk factors for onset of diabetes and cardiovascular disorders. We report a case vignette of a patient in whom the decrease in negative and general psychopathology after adjunctive aripiprazole appeared simultaneously with a reduction of clozapine-induced increase in weight and metabolic measures. Combined application of clozapine and aripiprazole is in accordance with a neurobiological rationale and appears to be a safe and well tolerated.
authors.affiliation: Charles University in Prague, Faculty of Medicine, Czech Republic. masopustj@lfhk.cuni.cz
authors.forename: Jirí
authors.initials: J
authors.lastname: Masopust
authors.forename: Ivan
authors.initials: I
authors.lastname: Tůma
authors.forename: Jan
authors.initials: J
authors.lastname: Libiger