Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk.
The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P \ 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.
Resic-Lindehammer
Sabina
S
Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Ent 72 Bldg 91 Floor 10, 205 02 Malmö, Sweden. sabina.lindehammer@med.lu.se
Larsson
K
K
Ortqvist
E
E
Carlsson
A
A
Cederwall
E
E
Cilio
C M
CM
Ivarsson
S-A
SA
Jönsson
B A
BA
Larsson
H E
HE
Lynch
K
K
Neiderud
J
J
Nilsson
A
A
Sjöblad
S
S
Lernmark
A
A
Aili
M
M
Bååth
L E
LE
Carlsson
E
E
Edenwall
H
H
Forsander
G
G
Granstro
B W
BW
Gustavsson
I
I
Hanås
R
R
Hellenberg
L
L
Hellgren
H
H
Holmberg
E
E
Hörnell
H
H
Ivarsson
Sten-A
SA
Johansson
C
C
Jonsell
G
G
Kockum
K
K
Lindblad
B
B
Lindh
A
A
Ludvigsson
J
J
Myrdal
U
U
Neiderud
J
J
Segnestam
K
K
Sjöblad
S
S
Skogsberg
L
L
Strömberg
L
L
Ståhle
U
U
Thalme
B
B
Tullus
K
K
Tuvemo
T
T
Wallensteen
M
M
Westphal
O
O
Aman
J
J