Inteferons pen the JAK-STAT pathway.
Characterization of how interferons (IFNs) mediate their biological response led to identification of the JAK-STAT signaling cascade, where JAKs are receptor-associated kinases and STATs the transcription factors they activate. Today, 4 JAKs and 7 STATs are known to transduce pivotal signals for the over 50 members of the four-helix bundle family of cytokines. This review will provide an overview and historical perspective of the JAK-STAT paradigm.
Schindler
Christian
C
Department of Microbiology, Columbia University, New York, NY 10032, USA. cws4@columbia.edu
Plumlee
Courtney
C