title: Total lymphocyte count: not a surrogate marker for risk of death in HIV-infected Ugandan children.
abstract: OBJECTIVE
  To determine the utility of total lymphocyte count (TLC) in predicting the 12-month mortality in HIV-infected Ugandan children and to correlate TLC and CD4 cell %.
  
  
  METHODS
  This is a retrospective data analysis of clinical and laboratory data collected prospectively on 128 HIV-infected children in the HIV Network for Prevention Trials 012 trial.
  
  
  METHODS
  TLC and CD4 cell % measurements were obtained at birth, 14 weeks, and 12, 24, 36, 48, and 60 months of age and assessed with respect to risk of death within 12 months.
  
  
  RESULTS
  Median TLC per microliter (CD4 cell %) was 4150 (41%) at birth, 4900 (24%) at 12 months, 4300 (19%) at 24 months, 4150 (19%) at 36 months, 4100 (18%) at 48 months, and 3800 (20%) at 60 months. The highest risk of mortality within 12 months was 34% - 37% at birth and declined to 13%-15% at 24 months regardless of TLC measurement. The correlation between CD4 cell % and TLC was extremely low overall (r = 0.01).
  
  
  CONCLUSIONS
  The TLC did not predict a risk of progression to death within 12 months in HIV-infected Ugandan children. Therefore, TLC alone may not be a useful surrogate marker for determining those children at highest risk of death, who require antiretroviral therapy most urgently.
authors.affiliation: Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda. pmusoke@mujhu.org
authors.forename: Philippa M
authors.initials: PM
authors.lastname: Musoke
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Young
authors.forename: Maxensia A
authors.initials: MA
authors.lastname: Owor
authors.forename: Irene R
authors.initials: IR
authors.lastname: Lubega
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Brown
authors.forename: Francis A
authors.initials: FA
authors.lastname: Mmiro
authors.forename: Lynne M
authors.initials: LM
authors.lastname: Mofenson
authors.forename: J Brooks
authors.initials: JB
authors.lastname: Jackson
authors.forename: Mary Glenn
authors.initials: MG
authors.lastname: Fowler
authors.forename: Laura A
authors.initials: LA
authors.lastname: Guay