Detection of VM55599 and preparaherquamide from Aspergillus japonicus and Penicillium fellutanum: biosynthetic implications.
The secondary metabolites VM55599 (4) and preparaherquamide (5) have been identified by LC-MS(n) analysis as natural metabolites in cultures of Penicillium fellutanum, whereas preparaherquamide has been identified only in cultures of Aspergillus japonicus. In accord with a previous proposal, the identification of both metabolites, which have a diastereomeric relationship, provides indirect support for a unified biosynthetic scheme.
Ding
Yousong
Y
Life Sciences Institute and Department of Medicinal Chemistry, The University of Michigan, 210 Washtenaw Avenue, Ann Arbor, Michigan 48109-2216, USA.
Gruschow
Sabine
S
Greshock
Thomas J
TJ
Finefield
Jennifer M
JM
Sherman
David H
DH
Williams
Robert M
RM