MR-spectroscopic findings in juvenile-onset Huntington's disease.
Seven HD gene positive individuals under the age of 21 years are described with clinical examination and proton-MR-spectroscopy ((1)H-MRS) profiles of the putamen. Despite clinical variability, the predominate (1)H-MRS abnormality is elevated glutamate, expressed well beyond the confines of the basal ganglia, and low striatal creatine.
Reynolds
Norman C
NC
Department of Neurology, VA Medical Center, Milwaukee, Wisconsin 53295, USA. nreynjr@msn.com
Prost
Robert W
RW
Mark
Leighton P
LP
Joseph
Suja A
SA