title: Expression of NLRP7 (PYPAF3, NALP7) protein in endometrial cancer tissues.
abstract: BACKGROUND
  Nucleotide-binding domain and leucine-rich repeat-containing family, pyrin domain-containing 7 (NLRP7) (pyrin-containing apoptotic protease activating factor-1-like protein 3; PYPAF3, NACHT domain-, leucine-rich repeat, and pyrin domain-containing 7; NALP7) has been thought to contribute to innate immunity and inflammation. Although expression of NLRP7 in human seminoma tissues and several cancer cell lines has been demonstrated, the pathophysiological and prognostic importance in cancer tissues has not been defined.
  
  
  METHODS
  A series of 70 endometrial cancer cases that had undergone curative resection was studied to determine the correlation between NLRP7 expression and clinico-pathological characteristics in human endometrial cancer tissue. Tissue specimens were evaluated for NLRP7 by immunohistochemistry.
  
  
  RESULTS
  NLRP7 expression was positive in cancer cells in 7 cases (10%). There was a statistical relationship between the depth of tumor invasion and NLRP7 expression (p=0.0326). NLRP7 expression showed a trend for being associated with poor prognosis.
  
  
  CONCLUSIONS
  Tumor-produced NLRP7, associated with myometrial invasion, might provide additional prognostic information in endometrial cancer patients.
authors.affiliation: Department of Complementary and Alternative Medicine Clinical R&D, Kanazawa University, Graduate School of Medical Science, Ishikawa, Japan. satoshio@med.kanazawa-u.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohno
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Ohno
authors.forename: Toshinari
authors.initials: T
authors.lastname: Minamoto
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Suzuki
authors.forename: Masaki
authors.initials: M
authors.lastname: Inoue
authors.forename: Takashi
authors.initials: T
authors.lastname: Suda