Copper-catalyzed oxidative coupling of benzylic C-H bonds with 1,3-dicarbonyl compounds.
A copper-catalyzed oxidative coupling of benzylic C-H bonds with 1,3-dicarbonyl compounds is described. The reaction utilizes an inexpensive copper catalyst-oxidant system that is suitable for the coupling of a range of benzylic C-H bonds with various 1,3-dicarbonyl compounds. Kinetic isotope studies support a mechanism involving a benzylic hydrogen abstraction.
Borduas
Nadine
N
Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Québec H9H 3L1, Canada.
Powell
David A
DA