title: Associations of endogenous sex hormones and sex hormone-binding globulin with lipid profiles in aged Japanese men and women.
abstract: BACKGROUND
  The associations of endogenous estrogen with lipid profiles and insulin resistance were conflicting in both men and women. We determined the associations of serum estradiol level and free estradiol index (FEI) with lipid profiles and insulin resistance in aged Japanese men and women.
  
  
  METHODS
  One hundred seventy-four men and 208 postmenopausal women aged from 50 to 85 y were included in this study. Lipid profiles, fasting glucose and insulin as well as estradiol, testosterone, dehydroepiandrosterone-sulfate (DHEA-S) and sex hormone-binding globulin (SHBG) in serum were measured.
  
  
  RESULTS
  Serum estradiol concentration in men showed a significant and negative correlation with high density lipoprotein-cholesterol (HDL-C) concentration and a significant and positive correlation with triglyceride (TG) after adjustment for age and body mass index (BMI). In addition, estradiol level was positively correlated with insulin and HOMA index. In women, serum levels of estradiol and testosterone were not correlated with lipid profiles and insulin resistance. SHBG concentration was negatively correlated with TG after adjustment for age and BMI in women.
  
  
  CONCLUSIONS
  Endogenous estradiol level is associated with unfavorable lipid profiles and insulin resistance in aged men. In aged women, SHBG level is associated with favorable lipid profiles.
authors.affiliation: Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. yasui@clin.med.tokushima-u.ac.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yasui
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Uemura
authors.forename: Minoru
authors.initials: M
authors.lastname: Irahara
authors.forename: Makoto
authors.initials: M
authors.lastname: Arai
authors.forename: Noriko
authors.initials: N
authors.lastname: Kojimahara
authors.forename: Ryugo
authors.initials: R
authors.lastname: Okabe
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Ishii
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Tashiro
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato