title: s-ICAM-1 and s-VCAM-1 in healthy men are strongly associated with traits of the metabolic syndrome, becoming evident in the postprandial response to a lipid-rich meal.
abstract: BACKGROUND
  The importance of the postprandial state for the early stages of atherogenesis is increasingly acknowledged. We conducted assessment of association between postprandial triglycerides, insulin and glucose after ingestion of a standardized lipid-rich test meal, and soluble cellular adhesion molecules (sCAM) in young healthy subjects.
  
  
  METHODS
  Metabolic parameters and sICAM-1, sVCAM-1 and E-selectin were measured before and hourly until 6 hours after ingestion of a lipid-rich meal in 30 healthy young men with fasting triglycerides <150 mg/dl and normal fasting glucose levels. Subjects were classified as either normal responders (NR) (postprandial triglyceride maxima < 260 mg/dl) or high responders (HR) (postprandial triglyceride maxima > 260 mg/dl). Levels of CAM were compared in HR and NR, and correlation with postprandial triglyceride, insulin and glucose response was assessed.
  
  
  RESULTS
  Fasting sICAM-1 and sVCAM-1 levels were significantly higher in HR as compared to NR (p = 0.046, p = 0.03). For sE-selectin there was such a trend (p = 0.05). There was a strong positive and independent correlation between sICAM-1 and postprandial insulin maxima (r = 0.70, p < 0.001). sVCAM-1 showed significant correlation with postprandial triglycerides (AUC) (r = 0.37, p = 0.047). We found no correlation between sCAMs and fasting insulin or triglyceride concentrations.
  
  
  CONCLUSIONS
  This independent association of postprandial triglycerides with sICAM-1 may indicate a particular impact of postprandial lipid metabolism on endothelial reaction.
authors.affiliation: Max-Rubner-Institut, Federal Research Center of Nutrition and Food, Herrmann-Weigmann-Str.1, 24103 Kiel, Germany. drubin@1med.uni-kiel.de
authors.forename: Diana
authors.initials: D
authors.lastname: Rubin
authors.forename: Sandra
authors.initials: S
authors.lastname: Claas
authors.forename: Maria
authors.initials: M
authors.lastname: Pfeuffer
authors.forename: Michael
authors.initials: M
authors.lastname: Nothnagel
authors.forename: Ulrich R
authors.initials: UR
authors.lastname: Foelsch
authors.forename: Juergen
authors.initials: J
authors.lastname: Schrezenmeir