title: Monocyte chemoattractant protein-1: a key mediator in inflammatory processes.
abstract: Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant for monocytes and macrophages to areas of inflammation. MCP-1 is a prototypical chemokine subject to coordinated regulation by immunomodulatory agents. Since MCP-1 is implicated in multiple inflammatory diseases, it is a potential target for the treatment of these disorders. In this review, we will provide background information and summarize the MCP-1 structure and signaling pathways. Its involvement in multiple diseases, such as tumour development, atherogenesis and rare autoimmune diseases is also revised.
authors.affiliation: Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, E-29071 Málaga, Spain. emelgarejo@uma.es
authors.forename: Esther
authors.initials: E
authors.lastname: Melgarejo
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Medina
authors.forename: Francisca
authors.initials: F
authors.lastname: Sánchez-Jiménez
authors.forename: José Luis
authors.initials: JL
authors.lastname: Urdiales