title: [Efficacy of therapy of different variants of anaplastic large T-cell lymphomas].
abstract: OBJECTIVE
  To compare efficacy of NHL-BFM-90 and CHOP-like courses in the treatment of anaplastic large cell lymphoma (ALCL).
  
  
  METHODS
  Twenty-two patients with ALCL participated in the study. The diagnosis was made basing on the findings of clinical, device, morphological, immunohistochemical and molecular-genetic examinations with application of a panel of monoclonal antibodies to CD30, ALK, CD3, CD4, CDS, CD7, CD34, CD15, CD68, CD20, CD45RO, CD45RA, Ki-67. 14 cases of 22 were negative by kinase of anaplastic lymphocytes (ALK-) and 8 were positive (ALK+). Mean age of ALK-ALCL patients was 39.6 +/- 4.1 years, of ALK+ALCL patients - 23.4 +/- 2.6 years. 14 patients were treated by the protocol NHL-BFM-90, 8 were initially treated with other schemes (CHOP, MACOP-B, BEACOPP and others). All 14 patients treated according to NHL-BFM-90 had ALCL stages III-IV with B-symptoms. 12 patients who completed treatment by the above protocol achieved complete remission after the forth course, 2 patients failed the treatment. Of 8 ALCL patients treated initially according to other schemes, a complete remission was achieved in 4 patients (2 had stage II). One of 4 patients with remission had recurrence. Four patients who had failed to achieve complete remission died of the disease progression.
  
  
  CONCLUSIONS
  ALCL occurs more frequently in young and middle-aged patients. The disease has an aggressive course with rapid generalization. For such processes it is more preferable to use a modified protocol NHL-BFM-90.
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Vinogradova
authors.forename: I N
authors.initials: IN
authors.lastname: Lutsenko
authors.forename: I B
authors.initials: IB
authors.lastname: Kaplanskaia
authors.forename: I A
authors.initials: IA
authors.lastname: Vorob'ev
authors.forename: R S
authors.initials: RS
authors.lastname: Samoĭlova
authors.forename: L A
authors.initials: LA
authors.lastname: Gorgidze
authors.forename: N A
authors.initials: NA
authors.lastname: Ryzhikova
authors.forename: T T
authors.initials: TT
authors.lastname: Valiev
authors.forename: E A
authors.initials: EA
authors.lastname: Giliazitdinova
authors.forename: U L
authors.initials: UL
authors.lastname: Dzhulakian
authors.forename: E K
authors.initials: EK
authors.lastname: Egorova
authors.forename: E E
authors.initials: EE
authors.lastname: Zvonkov
authors.forename: B B
authors.initials: BB
authors.lastname: Krasil'nikova
authors.forename: A U
authors.initials: AU
authors.lastname: Magomedova
authors.forename: O V
authors.initials: OV
authors.lastname: Margolin
authors.forename: D S
authors.initials: DS
authors.lastname: Mar'in
authors.forename: A M
authors.initials: AM
authors.lastname: Kremenetskaia
authors.forename: S K
authors.initials: SK
authors.lastname: Kravchenko
authors.forename: A I
authors.initials: AI
authors.lastname: Vorob'ev