title: Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion.
abstract: Deletion of 17p (TP53) identifies a rare subset of chronic lymphocytic leukaemia (17p- CLL) with aggressive behaviour. Genome-wide DNA-profiling was performed to investigate 18 patients with 17p- CLL. All cases had multiple copy-number (CN) changes. Among the several recurrent CN changes identified, 8q24.13-q24.1-gain (MYC), 8p-loss (TNFRSF10A/B, also known as TRAIL1/2) and 2p16.1-p14-gain (REL/BCL11A) appeared frequently represented. 8p-loss and 2p16.1-p14-gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p-loss) and overall survival (8p-loss and 2p16.1-p14-gain, P < 0.05). These observations document a highly unstable genome in 17p- CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.
authors.affiliation: Sezione Ematologia e Trapianti, Dipartimento di Medicina Clinica e Scienze Immunologiche, Università di Siena, Siena, Italy. forconif@unisi.it
authors.forename: Francesco
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authors.lastname: Forconi
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authors.lastname: Rinaldi
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authors.forename: Marta
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authors.lastname: Capello
authors.forename: Emanuele
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authors.lastname: Zucca
authors.forename: Daniela
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authors.lastname: Marconi
authors.forename: Riccardo
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authors.lastname: Bomben
authors.forename: Valter
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authors.lastname: Gattei
authors.forename: Francesco
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authors.lastname: Lauria
authors.forename: Gianluca
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authors.lastname: Gaidano
authors.forename: Francesco
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authors.lastname: Bertoni