title: Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.
abstract: Unlike the adjustable gastric banding procedure (AGB), Roux-en-Y gastric bypass surgery (RYGBP) in humans has an intriguing effect: a rapid and substantial control of type 2 diabetes mellitus (T2DM). We performed gastric lap-band (GLB) and entero-gastro anastomosis (EGA) procedures in C57Bl6 mice that were fed a high-fat diet. The EGA procedure specifically reduced food intake and increased insulin sensitivity as measured by endogenous glucose production. Intestinal gluconeogenesis increased after the EGA procedure, but not after gastric banding. All EGA effects were abolished in GLUT-2 knockout mice and in mice with portal vein denervation. We thus provide mechanistic evidence that the beneficial effects of the EGA procedure on food intake and glucose homeostasis involve intestinal gluconeogenesis and its detection via a GLUT-2 and hepatoportal sensor pathway.
authors.affiliation: Institut National de la Sante et de la Recherche Medicale, U695, Faculté de Médecine Xavier Bichat, Universite Paris 7, Paris, F-75870, France.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Troy
authors.forename: Maud
authors.initials: M
authors.lastname: Soty
authors.forename: Lara
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authors.lastname: Ribeiro
authors.forename: Laure
authors.initials: L
authors.lastname: Laval
authors.forename: Stéphanie
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authors.lastname: Migrenne
authors.forename: Xavier
authors.initials: X
authors.lastname: Fioramonti
authors.forename: Bruno
authors.initials: B
authors.lastname: Pillot
authors.forename: Veronique
authors.initials: V
authors.lastname: Fauveau
authors.forename: Roberte
authors.initials: R
authors.lastname: Aubert
authors.forename: Benoit
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authors.lastname: Viollet
authors.forename: Marc
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authors.lastname: Foretz
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Leclerc
authors.forename: Adeline
authors.initials: A
authors.lastname: Duchampt
authors.forename: Carine
authors.initials: C
authors.lastname: Zitoun
authors.forename: Bernard
authors.initials: B
authors.lastname: Thorens
authors.forename: Christophe
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authors.lastname: Magnan
authors.forename: Gilles
authors.initials: G
authors.lastname: Mithieux
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Andreelli