title: Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones.
abstract: A novel series of bacterial topoisomerase (3-aminoquinazolinediones) inhibitors are described. The side-chain SAR against Gram-positive and Gram-negative organisms as well as DNA gyrase activity is reported.
authors.affiliation: Pfizer Global Research and Development, Michigan Laboratories, Ann Arbor Campus, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. kim.hutchings@astrazeneca.com
authors.forename: Kim M
authors.initials: KM
authors.lastname: Hutchings
authors.forename: Tuan P
authors.initials: TP
authors.lastname: Tran
authors.forename: Edmund L
authors.initials: EL
authors.lastname: Ellsworth
authors.forename: Brian M
authors.initials: BM
authors.lastname: Watson
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Sanchez
authors.forename: H D
authors.initials: HD
authors.lastname: Showalter
authors.forename: Michael A
authors.initials: MA
authors.lastname: Stier
authors.forename: Martin
authors.initials: M
authors.lastname: Shapiro
authors.forename: E
authors.initials: E
authors.lastname: Themis Joannides
authors.forename: Michael
authors.initials: M
authors.lastname: Huband
authors.forename: Dai Q
authors.initials: DQ
authors.lastname: Nguyen
authors.forename: Samarendra
authors.initials: S
authors.lastname: Maiti
authors.forename: Tingsheng
authors.initials: T
authors.lastname: Li
authors.forename: Jyoti
authors.initials: J
authors.lastname: Tailor
authors.forename: George
authors.initials: G
authors.lastname: Thomas
authors.forename: Chan
authors.initials: C
authors.lastname: Ha
authors.forename: Rajeshwar
authors.initials: R
authors.lastname: Singh