title: [Chronic theatment with an endothelin-converting enzyme inhibitor reduces the development of hypoxia-induced pulmonary hypertension in rat].
abstract: The aim of this study was to investigate how blocking functional endothelin-converting enzyme activity may offer a new approach to inhibition of changes in pulmonary vessels reactivity due to development of hypoxia-induced pulmonary arterial hypertension in rats. This data shows that treatment with endothelin-converting enzyme blocker PP36 significantly reduced pathological changes due to hypoxia-induced pulmonary hypertension. One of the reasons may be the increased production and role of nitric oxide in pulmonary artery tone.
authors.forename: A I
authors.initials: AI
authors.lastname: Simonova
authors.forename: V F
authors.initials: VF
authors.lastname: Pozdneev
authors.forename: O A
authors.initials: OA
authors.lastname: Gomazkov
authors.forename: N A
authors.initials: NA
authors.lastname: Medvedeva