title: p53 strikes mTORC1 by employing sestrins.
abstract: The guardian of the genome (p53) elicits cell-cycle checkpoints in response to genotoxic stress. p53 also induces a metabolic checkpoint by inhibiting the mammalian target of rapamycin complex 1 (mTORC1). Recent results by Budanov and Karin, (2008) reveal that p53 exerts its effect on mTORC1 through sestrin1 and sestrin2.
authors.affiliation: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA. nhay@uic.edu
authors.forename: Nissim
authors.initials: N
authors.lastname: Hay