title: Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes.
abstract: We designed and synthesized a series of novel 3,6-bicyclolide oximes, possessing linkers of varying lengths to the secondary binding site. The E isomers exhibited excellent antibacterial profiles against a broad spectrum of resistant pathogens.
authors.affiliation: Enanta Pharmaceuticals, Inc., 500 Arsenal Street, Watertown, MA 02472, USA. dtang@enanta.com
authors.forename: Datong
authors.initials: D
authors.lastname: Tang
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Gai
authors.forename: Alexander
authors.initials: A
authors.lastname: Polemeropoulos
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Chen
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
authors.forename: Yat Sun
authors.initials: YS
authors.lastname: Or