title: Periocular dermatitis: a report of 401 patients.
abstract: BACKGROUND
  Periocular contact dermatitis may appear as contact conjunctivitis, contact allergic and/or irritative eyelid and periorbital dermatitis, or a combination of these symptoms. The clinical symptoms may be induced by several environmental and therapeutic contact allergens.
  
  
  OBJECTIVE
  The aim of the present study was to map the eliciting contact allergens in 401 patients with periocular dermatitis (PD) by patch testing with environmental and ophthalmic contact allergens.
  
  
  METHODS
  Following the methodics of international requirements, 401 patients were tested with contact allergens of the standard environmental series, 133 of 401 patients with the Brial ophthalmic basic and supplementary series as well.
  
  
  RESULTS
  Contact hypersensitivity was detected in 34.4% of the patients. Highest prevalence was seen in cases of PD without other symptoms (51.18%), in patients of PD associated with ophthalmic complaints (OC; 30.4%), and PD associated with atopic dermatitis (AD; 27.9%). In the subgroup of PD associated with seborrhoea (S) and rosacea (R), contact hypersensitivity was confirmed in 17.6%. Most frequent sensitisers were nickel sulphate (in 8.9% of the tested 401 patients), fragrance mix I (4.5%), balsam of Peru (4.0%), paraphenylendiamine (PPD) (3.7%), and thiomersal (3.5%). By testing ophthalmic allergens, contact hypersensitivity was observed in nine patients (6.7% of the tested 133 patients). The most common confirmed ophthalmic allergens were cocamidopropyl betaine, idoxuridine, phenylephrine hydrochloride, Na chromoglycinate, and papaine.
  
  
  CONCLUSIONS
  Patients with symptoms of PD were tested from 1996 to 2006.
  
  
  CONCLUSIONS
  The occurence of contact hypersensitivity in PD patients was in present study 34.4%. A relatively high occurrence was seen in cases of PD without other symptoms, in PD + OC and in PD + AD patients. The predominance of environmental contact allergens was remarkable: most frequent sensitizers were nickel sulphate, fragrance mix I, balsam of Peru, thiomersal, and PPD. The prevalence of contact hypersensitivity to ophthalmic allergens did not exceed l.5%.
authors.affiliation: Faculty of Medicine, Department of Dermatology, Venerology and Dermatooncology, Semmelweis University, Budapest, Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Temesvári
authors.forename: G
authors.initials: G
authors.lastname: Pónyai
authors.forename: I
authors.initials: I
authors.lastname: Németh
authors.forename: B
authors.initials: B
authors.lastname: Hidvégi
authors.forename: A
authors.initials: A
authors.lastname: Sas
authors.forename: S
authors.initials: S
authors.lastname: Kárpáti