Mitochondrial genetic polymorphisms do not predict survival in patients with pancreatic cancer.
Pancreatic cancer is a highly lethal malignancy, and the majority of patients succumb to the disease within 2 years. We evaluated the role of variants of mitochondrial DNA and mitochondrial haplogroups in predicting prognosis of patients with pancreatic cancer. A total of 24 mitochondrial single nucleotide polymorphisms were genotyped in 990 patients with pancreatic cancer. After adjusting for covariates and multiple comparisons, no association between any of the mitochondrial single nucleotide polymorphisms or haplogroups and survival was observed.
Halfdanarson
Thorvardur R
TR
Department of Internal Medicine, Division of Hematology, Oncology and Blood & Marrow Transplantation, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA. thorvardur-halfdanarson@uiowa.edu
Wang
Liang
L
Bamlet
William R
WR
de Andrade
Mariza
M
McWilliams
Robert R
RR
Cunningham
Julie M
JM
Petersen
Gloria M
GM