title: Discovery of thieno[2,3-c]pyridines as potent COT inhibitors.
abstract: Evaluation of hit chemotypes from high throughput screening identified a novel series of 2,4-disubstituted thieno[2,3-c]pyridines as COT kinase inhibitors. Structural modifications exploring SAR at the 2- and 4-positions resulting in inhibitors with improved enzyme potency and cellular activity are disclosed.
authors.affiliation: Abbott Bioresearch Center, 381 Plantation Street, Worcester, MA 01605, USA. dawn.george@abbott.com
authors.forename: Dawn
authors.initials: D
authors.lastname: George
authors.forename: Michael
authors.initials: M
authors.lastname: Friedman
authors.forename: Hamish
authors.initials: H
authors.lastname: Allen
authors.forename: Maria
authors.initials: M
authors.lastname: Argiriadi
authors.forename: Claude
authors.initials: C
authors.lastname: Barberis
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Bischoff
authors.forename: Anca
authors.initials: A
authors.lastname: Clabbers
authors.forename: Kevin
authors.initials: K
authors.lastname: Cusack
authors.forename: Richard
authors.initials: R
authors.lastname: Dixon
authors.forename: Shannon
authors.initials: S
authors.lastname: Fix-Stenzel
authors.forename: Thomas
authors.initials: T
authors.lastname: Gordon
authors.forename: Bernd
authors.initials: B
authors.lastname: Janssen
authors.forename: Yong
authors.initials: Y
authors.lastname: Jia
authors.forename: Maria
authors.initials: M
authors.lastname: Moskey
authors.forename: Christopher
authors.initials: C
authors.lastname: Quinn
authors.forename: Jose-Andres
authors.initials: JA
authors.lastname: Salmeron
authors.forename: Neil
authors.initials: N
authors.lastname: Wishart
authors.forename: Kevin
authors.initials: K
authors.lastname: Woller
authors.forename: Zhengtian
authors.initials: Z
authors.lastname: Yu