title: Unicentric castleman disease is not clearly distinguished from multicentric type: a case report.
abstract: Castleman disease (CD) was recently classified as a unicentric hyaline vascular variant, unicentric plasma cell variant, and multicentric plasma cell variant. It is rare that unicentric CD is presented as multiple retroperitoneal lymphadenopathy. The clinical manifestations and prognosis depends on histologic type. We report an unusual case of CD with multiple retroperitoneal lymphadenopathy, which had unicentric hyaline vascular variant histologically but was clinically multicentric. The patient experienced anemia, weight loss, elevated C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome), and plasmacytosis in bone marrow without human herpesvirus-8 or HIV. After exploratory laparotomy and lymphadenectomy under presumptive diagnosis of CD, the patient's symptoms recovered, and CRP and ESR decreased. Therefore, we suggest that unicentric CD is not clearly distinguished from multicentric, the type in this report, focusing on the useful role of CRP, ESR, and positron emission tomography/computed tomography in the disease activity of CD.
authors.affiliation: Department of Internal Medicine, Eulji University College of Medicine, Seoul, South Korea.
authors.forename: Jeoung Ho
authors.initials: JH
authors.lastname: Choi
authors.forename: Yun Ju
authors.initials: YJ
authors.lastname: Jo
authors.forename: Soo Jung
authors.initials: SJ
authors.lastname: Gong
authors.forename: Boo Whan
authors.initials: BW
authors.lastname: Hong
authors.forename: Ho Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Byoung Kwan
authors.initials: BK
authors.lastname: Son
authors.forename: Dae Won
authors.initials: DW
authors.lastname: Jun
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Young Sook
authors.initials: YS
authors.lastname: Park
authors.forename: Ju Won
authors.initials: JW
authors.lastname: Seok