title: Differential regulation of the antiapoptotic action of B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma extra long (Bcl-xL) by c-Jun N-terminal protein kinase (JNK) 1-involved pathway in neuroglioma cells.
abstract: Here, we confirmed that stable expression of B-cell lymphoma-xL (Bcl-xL) in N18TG neuroglioma cells could suppress c-Jun N-terminal protein kinase (JNK) activation, nuclear fragmentation, and cell death caused by etoposide treatment. Moreover, additional overexpression of JNK1 led to partially antagonize the antiapoptotic environment attained by Bcl-xL, implying that JNK1-involved pathway may play a role in down-regulation of the antiapoptotic effect of Bcl-xL. However, the antagonistic effect of JNK1 on the antiapoptotic action of Bcl-xL was significantly weaker than that on the action of Bcl-2. Interestingly, we found that overexpression of JNK1 led to increase of Bcl-xL expression. Thus, these results suggest that Bcl-xL and Bcl-2 may induce its antiapoptotic effect in a different mechanism, provoking the possibility of involvement of JNK1-involved pathway in Bcl-xL expression.
authors.affiliation: Department of Animal Biotechnology, Konkuk University, Seoul, Korea.
authors.forename: Hyo-Soon
authors.initials: HS
authors.lastname: Jeong
authors.forename: Hye-Yeon
authors.initials: HY
authors.lastname: Choi
authors.forename: Tae-Won
authors.initials: TW
authors.lastname: Choi
authors.forename: Bong-Woo
authors.initials: BW
authors.lastname: Kim
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Eung-Ryoung
authors.initials: ER
authors.lastname: Lee
authors.forename: Ssang-Goo
authors.initials: SG
authors.lastname: Cho