In vitro interactions of itraconazole and micafungin against clinically important filamentous fungi.
The in vitro interactions between itraconazole and micafungin against 133 strains of filamentous fungi of clinical interest were evaluated using a checkerboard method. Overall, synergistic interactions were observed against 30% of the strains tested. In the cases of Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, Fonsecaea spp. and Sporothrix schenckii, synergistic interactions were observed against > or = 50% of the strains tested. For the rest of the fungi the interaction was indifferent; antagonism was not observed in any case.
Ruíz-Cendoya
Mery
M
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain.
Rodriguez
M Mar
MM
Mariné
Marçal
M
Pastor
F Javier
FJ
Guarro
Josep
J