title: A role of IgE and CD23/NO immune pathway in age-related resistance of Lewis rats to Plasmodium berghei Anka?
abstract: In contrast to young rats, adult rats given i.p. Plasmodium berghei Anka (PbA) control the parasitaemia and repair their anaemia. Here, we investigated whether IgE and CD23/NO immune pathway could be implicated in this age-related resistance of adult rats to PbA. Eight-week-old rats displayed significantly higher levels of plasma total IgE (p=0.01) and soluble CD23 (p=0.003) during the peak of parasitaemia, compared to 4-week-old rats. IgE Fc-binding antibody or aminoguanidine administration to parasitized 8-week-old rats slightly delayed blood parasite clearance or exacerbated anaemia. These data suggest that IgE and CD23/NO could play an important role in the resistance of adult rats experiencing PbA primary intraerythrocytic development.
authors.affiliation: EA 3677, Bases thérapeutiques des inflammations et infections, Université Victor Segalen Bordeaux II, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. safeukui@pasteur.fr
authors.forename: Innocent
authors.initials: I
authors.lastname: Safeukui
authors.forename: Rémi
authors.initials: R
authors.lastname: Vatan
authors.forename: Mariette
authors.initials: M
authors.lastname: Dethoua
authors.forename: Hervé
authors.initials: H
authors.lastname: Agbo
authors.forename: Gilbert
authors.initials: G
authors.lastname: Haumont
authors.forename: Daniel
authors.initials: D
authors.lastname: Moynet
authors.forename: Denis
authors.initials: D
authors.lastname: Malvy
authors.forename: Philippe
authors.initials: P
authors.lastname: Vincendeau
authors.forename: Djavad
authors.initials: D
authors.lastname: Mossalayi
authors.forename: Pascal
authors.initials: P
authors.lastname: Millet