title: Detection of VM55599 and preparaherquamide from Aspergillus japonicus and Penicillium fellutanum: biosynthetic implications.
abstract: The secondary metabolites VM55599 (4) and preparaherquamide (5) have been identified by LC-MS(n) analysis as natural metabolites in cultures of Penicillium fellutanum, whereas preparaherquamide has been identified only in cultures of Aspergillus japonicus. In accord with a previous proposal, the identification of both metabolites, which have a diastereomeric relationship, provides indirect support for a unified biosynthetic scheme.
authors.affiliation: Life Sciences Institute and Department of Medicinal Chemistry, The University of Michigan, 210 Washtenaw Avenue, Ann Arbor, Michigan 48109-2216, USA.
authors.forename: Yousong
authors.initials: Y
authors.lastname: Ding
authors.forename: Sabine
authors.initials: S
authors.lastname: Gruschow
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Greshock
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Finefield
authors.forename: David H
authors.initials: DH
authors.lastname: Sherman
authors.forename: Robert M
authors.initials: RM
authors.lastname: Williams