title: Interspecies recombination occurs frequently in quinolone resistance-determining regions of clinical isolates of Streptococcus pyogenes.
abstract: Fluoroquinolone resistance in Streptococcus pyogenes has been reported only anecdotally, but a recent Belgian surveillance study found a rate of nonsusceptibility of 5.4%. From an analysis of these isolates, we show that interspecies horizontal gene transfer within the parC quinolone resistance-determining region is a frequent phenomenon that might contribute to fluoroquinolone resistance.
authors.affiliation: Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
authors.forename: Christoph B
authors.initials: CB
authors.lastname: Duesberg
authors.forename: Surbhi
authors.initials: S
authors.lastname: Malhotra-Kumar
authors.forename: Herman
authors.initials: H
authors.lastname: Goossens
authors.forename: Lesley
authors.initials: L
authors.lastname: McGee
authors.forename: Keith P
authors.initials: KP
authors.lastname: Klugman
authors.forename: Tobias
authors.initials: T
authors.lastname: Welte
authors.forename: Mathias W R
authors.initials: MW
authors.lastname: Pletz