Plasma exchange in immune-mediated neuropathies.
OBJECTIVE
Plasma exchange is frequently used for treatment of immune-mediated neuropathies. Here, we review the current value of plasma exchange in the treatment of different forms of immune-mediated neuropathies and discuss latest developments.


RESULTS
Plasma exchange is used in various disease conditions; however, of all immune-mediated disorders of the peripheral nerve, Guillain-Barré syndrome represents the disease entity in which short and long-term efficacy, optimal frequency, side effects and cost effectiveness of plasma exchange are best documented. Although randomized trials evaluated the value of plasma exchange in chronic forms of immune-neuropathies, its long-term efficacy and its optimal frequency still remain unclear.


CONCLUSIONS
Especially in chronic forms of immune-mediated neuropathies, plasma exchange needs to be further evaluated in clinical trials to assess long-term efficacy and its potential as adjuvant treatment option.
Lehmann
Helmar C
HC
Department of Neurology, Heinrich Heine University, Düsseldorf, Germany. helmar.lehmann@uni-duesseldorf.de
Hartung
Hans-Peter
HP
Meyer Zu Hörste
Gerd
G
Kieseier
Bernd C
BC