title: A case of black thyroid associated with hyalinizing trabecular tumor.
abstract: Black thyroid is an uncommon phenomenon of black pigmentation of thyroid parenchyma induced by chronic minocycline therapy. Thyroid tumors associated with black pigmented thyroid are rare. We describe here a 42-year-old woman with a black thyroid associated with hyalinizing trabecular tumor (HTT). The patient presented with a palpable left-sided thyroid nodule. She had taken minocycline for aphthous stomatitis and an oral ulcer for 9 years. The findings of fine needle aspiration biopsy and BRAF mutation analysis suggested a papillary carcinoma. The patient underwent a near-total thyroidectomy with central compartment node dissection. The surgical specimen showed a diffuse black thyroid and a 2-cm non-pigmented, well-circumscribed nodule in the left thyroid. Histopathologically, numerous black pigmented follicular epithelial cells and colloid were seen throughout the thyroid parenchyma, and the nodule was composed of elongated, polygonal cells in trabecular arrangement and dense hyaline stromas. The tumor cells showed a strong positive cytoplasmic reaction to Ki 67. All of these findings suggested a HTT, or a hyalinizing trabecular variant of papillary carcinoma, arising in a black thyroid. To our knowledge, this is the first case of black thyroid associated with HTT.
authors.affiliation: Thyroid Cancer Clinic, Yonsei University College of Medicine, Seodaemun-gu, Seoul, South Korea.
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Kang
authors.forename: Soon Won
authors.initials: SW
authors.lastname: Hong
authors.forename: Pyo Ju
authors.initials: PJ
authors.lastname: Yeon
authors.forename: Jong Ju
authors.initials: JJ
authors.lastname: Jeong
authors.forename: Tae Yon
authors.initials: TY
authors.lastname: Sung
authors.forename: Seung Chul
authors.initials: SC
authors.lastname: Lee
authors.forename: Yong Sang
authors.initials: YS
authors.lastname: Lee
authors.forename: Kee-Hyun
authors.initials: KH
authors.lastname: Nam
authors.forename: Woong Youn
authors.initials: WY
authors.lastname: Chung
authors.forename: Hang Seok
authors.initials: HS
authors.lastname: Chang
authors.forename: Cheong Soo
authors.initials: CS
authors.lastname: Park