title: Long-term postoperative adjuvant chemotherapy of UFT/LV improves survival in a primary tumor resection-pulmonary metastasis model.
abstract: BACKGROUND
  The optimum regimen and optimum duration of administration of postoperative chemotherapy would vary with the postoperative residual tumor volume. Whether or not prolonged administration of oral uracil/tegafur (UFT) with leucovorin (LV) would prolong the survival period was assessed experimentally.
  
  
  METHODS
  Murine models of pulmonary metastasis with different volumes of residual tumor after primary tumor resection were prepared, and the efficacy of 12-week and 4-week oral administration of UFT/LV as postoperative adjuvant chemotherapy was compared.
  
  
  RESULTS
  In the model with only a small volume of occult residual tumor after early resection of the primary tumor, the survival period in the 12-week UFT/LV group was significantly increased as compared with that in the untreated group, whereas no significant difference was noted between the 4-week UFT/LV group and the untreated group.
  
  
  CONCLUSIONS
  Long-term administration of UFT/LV as postoperative adjuvant chemotherapy may be potentially beneficial.
authors.affiliation: Department of Surgery, Tokai University, Japan. sadahiro@is.icc.utokai.ac.jp
authors.forename: Sotaro
authors.initials: S
authors.lastname: Sadahiro
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Maeda
authors.forename: Akira
authors.initials: A
authors.lastname: Tanaka
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Makuuchi
authors.forename: Akemi
authors.initials: A
authors.lastname: Kamijo
authors.forename: Chieko
authors.initials: C
authors.lastname: Murayama