Tailored polymer-supported templates in dynamic combinatorial libraries: simultaneous selection, amplification and isolation of synthetic receptors.
The thermodynamically controlled synthesis and isolation of macrocyclic receptors from dynamic combinatorial libraries has been achieved in a single step using a polymer-supported template. The templates were cinchona alkaloids which show interesting enantio- and diastereoselective molecular recognition events in libraries based on pseudo-dipeptide building blocks. The synthetic routes used to derivatise the alkaloids and attach them to polymer supports minimised any influence of the tethering linkage on the templating activity. Systematic studies have been carried out to probe how the polymer morphology and the template loading affect the selectivity and isolation yield of the macrocyclic receptors. Molecular recognition between solid-phase bound templates and selected receptors also enabled their affinity-type chromatographic separation.
Besenius
Pol
P
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL (UK), Fax: (+44) 141-548-4246.
Cormack
Peter A G
PAG
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL (UK), Fax: (+44) 141-548-4246.
Liu
Jingyuan
J
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK).
Otto
Sijbren
S
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK).
Sanders
Jeremy K M
JKM
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK).
Sherrington
David C
DC
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL (UK), Fax: (+44) 141-548-4246.