title: Anti-inflammatory effects of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) in animal models.
abstract: BACKGROUND
  KHU14, an ethanolic extract of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) was tested for its anti-inflammatory effects.
  
  
  METHODS
  Three out of 20 herbs were found to have anti-inflammatory effects. The formulation of these herbs, i.e. KHU14 was tested for croton oil-induced ear edema, carrageenan-induced paw edema, acetic acid-induced capillary permeability, cotton pellet and delayed type hypersensitivity.
  
  
  RESULTS
  KHU14 exhibited anti-inflammatory effects in animal models of acute and chronic inflammation. The anti-inflammatory activity of KHU14 observed was comparable to that of celecoxib. KHU14 inhibited the production of NO and PGE2 in LPS/IFN-gamma-stimulated peritoneal macrophages, and reduced edema and the amount of infiltrated cells in animal models.
  
  
  CONCLUSIONS
  KHU14 exhibited anti-inflammatory effects as demonstrated in typical immunological tests for anti-inflammation in vitro and in vivo.
authors.affiliation: East-West Bone and Joint Research Center, Kyung Hee University Neo Medical Hospital, Seoul, South Korea. labrea46@yahoo.co.kr
authors.forename: Kyoung Soo
authors.initials: KS
authors.lastname: Kim
authors.forename: Hae In
authors.initials: HI
authors.lastname: Rhee
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Park
authors.forename: Kiwon
authors.initials: K
authors.lastname: Jung
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Jeon
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Hunseung
authors.initials: H
authors.lastname: Yoo
authors.forename: Chang-Kyun
authors.initials: CK
authors.lastname: Han
authors.forename: Yong-Baik
authors.initials: YB
authors.lastname: Cho
authors.forename: Chun Jeih
authors.initials: CJ
authors.lastname: Ryu
authors.forename: Hyung In
authors.initials: HI
authors.lastname: Yang
authors.forename: Myung Chul
authors.initials: MC
authors.lastname: Yoo