title: Triple X syndrome with rare phenotypic presentation.
abstract: Triple X syndrome is a rare numerical chromosomal anomaly, occurring as a result of non dysjunction in meiosis I. Most cases have neurodevelopmental defects and functional problems. We report two cases diagnosed in our centre. The first was a fetus with cleft lip and palate, 47, XXX was identified by Fetal Blood Sampling. The second was a child with multisystem anomaly including cleft lip and palate, whose karyotype also revealed 47, XXX. Though isolated cases of associated abnormalities have been reported there have not been consistent phenotypic changes reported with this condition.
authors.affiliation: Department of Genetics, A Unit of Mediscan Systems, 197, Dr Natesan Road, Mylapore, Chennai, India. fcrfchennai@yahoo.com
authors.forename: Sujatha
authors.initials: S
authors.lastname: Jagadeesh
authors.forename: Gazala
authors.initials: G
authors.lastname: Jabeen
authors.forename: Lathaa
authors.initials: L
authors.lastname: Bhat
authors.forename: Madhavi
authors.initials: M
authors.lastname: Vasikarla
authors.forename: Arvind
authors.initials: A
authors.lastname: Suresh
authors.forename: Suresh
authors.initials: S
authors.lastname: Seshadri
authors.forename: S
authors.initials: S
authors.lastname: Lata