Muscarinic receptor antagonism causes a functional alteration in nucleus accumbens mu-opiate-mediated feeding behavior.
Intra-nucleus accumbens (Acb) infusion of cholinergic muscarinic antagonist, scopolamine (10 microg/0.5 microl), markedly reduced fat intake elicited by intra-Acb treatment of the mu-opioid receptor agonist, DAMGO, with 30 min and 4h pretreatment intervals. Intra-Acb scopolamine infusions also reduced food intake in food-deprived rats, but not water intake in water-deprived rats. Hence, Acb muscarinic manipulations exhibit some specificity for feeding, perhaps via interactions with the striatal opioid system.
Perry
Michelle L
ML
Molecular and Cellular Pharmacology, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.
Baldo
Brian A
BA
Andrzejewski
Matthew E
ME
Kelley
Ann E
AE