Remote induction of asymmetry in [13]-macro-dilactone topology by a single stereogenic center.
Analysis of a series of unsaturated [13]-macro-dilactones showed that the configuration of a single carbon dictates the planar chirality of a macrocycle backbone and in turn remotely switches the facial display of an embedded alkene unit.
Fyvie
W Sean
WS
Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA.
Peczuh
Mark W
MW