Effects of krill oil on serum lipids of hyperlipidemic rats and human SW480 cells.
BACKGROUND
Cardiovascular disease (CVD) and colon cancer incidence are known to be closely related to dietary factors. This article evaluated effects of krill oil (KO) on serum lipids of hyperlipidemia rats and human colon cancer cells (SW480). Serum lipids of rats fed with high fat diet (HFD) and different doses of KO were measured by automatic analyzer. Effect of KO on viability of cells was determined by methyl thiazolyl tetrazolium (MTT) assay.


RESULTS
Except for higher dose group, body weights decreased significantly. Total cholesterol (TC), LDL-cholesterol (LDL-C) of all dose groups, Triglycerides (TG) of low and mid dose groups descended significantly, while there were no significant differences of HDL-cholesterol (HDL-C), compared with control group. Treatment of colon cancer cells with KO also resulted in time-dependent inhibition of cell growth.


CONCLUSIONS
Our findings indicated that the consumption of KO may provide benefits to control serum lipid levels in certain diseases and inhibit growth of colon cancer cells. Therefore, KO may be a good candidate for development as a functional food and nutraceutical.
Zhu
Jia-Jin
JJ
Department of Food Science and Nutrition, Zhejiang University, Hangzhou, PR China. jjzhu@zju.edu.cn
Shi
Jia-Hui
JH
Qian
Wen-Bin
WB
Cai
Zhen-Zhen
ZZ
Li
Duo
D