Junceols D-H, new polyoxygenated briaranes from sea whip gorgonian coral Junceella juncea (Ellisellidae).
Chemical investigations on the sea whip gorgonian coral Junceella juncea have led to the isolation of five new 8-hydroxybriarane diterpenoids, junceols D-H (1-5). The structures of briaranes 1-5 were determined on the basis of spectroscopic methods and the methylenecyclohexane rings were found to exist in boat form in these new diterpenoids. Junceols D (1) and F-H (3-5) exhibited cytotoxicity toward CCRF-CEM and DLD-1 tumor cells and junceols E-H (2-5) displayed weak inhibitory effects on superoxide anion generation by human neutrophils.
Sung
Ping-Jyun
PJ
Taiwan Coral Research Center (TCRC), National Museum of Marine Biology & Aquarium (NMMBA), Checheng, Pingtung, Taiwan. pjsung@nmmba.gov.tw
Pai
Chen-Hao
CH
Hwang
Tsong-Long
TL
Fan
Tung-Yung
TY
Su
Jui-Hsin
JH
Chen
Jih-Jung
JJ
Fang
Lee-Shing
LS
Wang
Wei-Hsien
WH
Sheu
Jyh-Horng
JH