title: Monitoring the accumulation of lipofuscin in aging murine eyes by fluorescence spectroscopy.
abstract: The integrated fluorescence of murine eyes is collected as a function of age. This fluorescence is attributed to pigments generally referred to as lipofuscin and is observed to increase with age. No difference in fluorescence intensity is observed between the eyes of males or females. This work provides a benchmark for further studies that are planned in order to use such signatures as markers of central nervous system (CNS) tissue or even of diseased CNS tissue and provides a basis for determining the age of a healthy animal.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, IA, USA.
authors.forename: Prasun
authors.initials: P
authors.lastname: Mukherjee
authors.forename: Sayantan
authors.initials: S
authors.lastname: Bose
authors.forename: Alyse A
authors.initials: AA
authors.lastname: Hurd
authors.forename: Ramkrishna
authors.initials: R
authors.lastname: Adhikary
authors.forename: Holger
authors.initials: H
authors.lastname: Schönenbrücher
authors.forename: Amir N
authors.initials: AN
authors.lastname: Hamir
authors.forename: Jürgen A
authors.initials: JA
authors.lastname: Richt
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Casey
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rasmussen
authors.forename: Jacob W
authors.initials: JW
authors.lastname: Petrich