title: Phenylethyl cinnamides: a new series of alpha-glucosidase inhibitors from the leaves of Aegle marmelos.
abstract: A series of phenylethyl cinnamides, which included new compounds named anhydromarmeline, aegelinosides A and B, were isolated from Aegle marmelos leaves as alpha-glucosidase inhibitors. The structures of new compounds were characterized by spectroscopic data and chemical degradation. Of compounds isolated, anhydroaegeline revealed the most potent inhibitory effect against alpha-glucosidase with IC(50) value of 35.8 microM. The present result also supports ethnopharmacological use of A. marmelos as a remedy for diabetes mellitus.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand. preecha.p@chula.ac.th
authors.forename: Preecha
authors.initials: P
authors.lastname: Phuwapraisirisan
authors.forename: Thanchanok
authors.initials: T
authors.lastname: Puksasook
authors.forename: Jonkolnee
authors.initials: J
authors.lastname: Jong-Aramruang
authors.forename: Udom
authors.initials: U
authors.lastname: Kokpol