title: Evaluation of the antiproliferative activity of 2-(monohalogenophenylamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles.
abstract: Two 2-(monohalogenophenylamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles were synthesized by reaction of sulfinyl bis(2,4-dihydroxythiobenzoyl) with 4-substituted 3-thiosemicarbazides and evaluated for their antiproliferative activity in tumor cells and for cytotoxicity in normal cells. Both derivatives in micromolar concentrations elicited a prominent antiproliferative effect in tumor cells derived from cancers of the nervous system (rhabdomyosarcoma/medulloblastoma, glioma) and peripheral cancers, including breast adenocarcinoma and lung carcinoma. The anticancer effect was attributed to decreased DNA synthesis and was not connected with apoptosis induction. Both compounds were not toxic to normal human skin fibroblasts.
authors.affiliation: Department of Toxicology, Institute of Agricultural Medicine, Lublin, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Juszczak
authors.forename: Joanna
authors.initials: J
authors.lastname: Matysiak
authors.forename: Wojciech
authors.initials: W
authors.lastname: Brzana
authors.forename: Andrzej
authors.initials: A
authors.lastname: Niewiadomy
authors.forename: Wojciech
authors.initials: W
authors.lastname: Rzeski