title: 1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.
abstract: The design, synthesis, and structure-activity studies of a novel series of BK B(1) receptor antagonists based on a 1-benzylbenzimidazole chemotype are described. A number of compounds, for example, 38g, with excellent affinity for the cynomolgus macaque and rat bradykinin B(1) receptor were discovered.
authors.affiliation: Neurogen Corporation, 35 NE Industrial Road, Branford, CT 06405, USA.
authors.forename: Qin
authors.initials: Q
authors.lastname: Guo
authors.forename: Jayaraman
authors.initials: J
authors.lastname: Chandrasekhar
authors.forename: David
authors.initials: D
authors.lastname: Ihle
authors.forename: David J
authors.initials: DJ
authors.lastname: Wustrow
authors.forename: Bertrand L
authors.initials: BL
authors.lastname: Chenard
authors.forename: James E
authors.initials: JE
authors.lastname: Krause
authors.forename: Alan
authors.initials: A
authors.lastname: Hutchison
authors.forename: Dawn
authors.initials: D
authors.lastname: Alderman
authors.forename: Charles
authors.initials: C
authors.lastname: Cheng
authors.forename: Daniel
authors.initials: D
authors.lastname: Cortright
authors.forename: Daniel
authors.initials: D
authors.lastname: Broom
authors.forename: Mark T
authors.initials: MT
authors.lastname: Kershaw
authors.forename: Jean
authors.initials: J
authors.lastname: Simmermacher-Mayer
authors.forename: Yao
authors.initials: Y
authors.lastname: Peng
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Hodgetts