Pontin and reptin, two related ATPases with multiple roles in cancer.
Studies in model organisms or cultured human cells suggest potential implications in carcinogenesis for the AAA+ ATPases Pontin and Reptin. Both proteins are associated with several chromatin-remodeling complexes and have many functions including transcriptional regulation, DNA damage repair, and telomerase activity. They also interact with major oncogenic actors such as beta-catenin and c-myc and regulate their oncogenic function. We only now begin to get insight into the role of Pontin and Reptin in human cancers.
Huber
Otmar
O
Department of Laboratory Medicine and Pathobiochemistry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Ménard
Ludovic
L
Haurie
Valérie
V
Nicou
Alexandra
A
Taras
Danièle
D
Rosenbaum
Jean
J