title: Muscarinic receptor antagonism causes a functional alteration in nucleus accumbens mu-opiate-mediated feeding behavior.
abstract: Intra-nucleus accumbens (Acb) infusion of cholinergic muscarinic antagonist, scopolamine (10 microg/0.5 microl), markedly reduced fat intake elicited by intra-Acb treatment of the mu-opioid receptor agonist, DAMGO, with 30 min and 4h pretreatment intervals. Intra-Acb scopolamine infusions also reduced food intake in food-deprived rats, but not water intake in water-deprived rats. Hence, Acb muscarinic manipulations exhibit some specificity for feeding, perhaps via interactions with the striatal opioid system.
authors.affiliation: Molecular and Cellular Pharmacology, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Perry
authors.forename: Brian A
authors.initials: BA
authors.lastname: Baldo
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Andrzejewski
authors.forename: Ann E
authors.initials: AE
authors.lastname: Kelley