Effect of selenium compound (selol) on the opioid activity in vincristine induced hyperalgesia.
OBJECTIVE
Effect of organoselenium compound (selol), on antinociceptive action of opioid agonists in vincristine neuropathic pain model was investigated.


METHODS
The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto.


RESULTS
Daily administration of VIN (70 microg/kg, iv) resulted in progressive decrease of pain threshold. Neither morphine, fentanyl nor buprenorphine administered alone in 5 consecutive days modified the vincristine-induced hyperalgesia, whereas selol slightly increased the nociceptive threshold. Co-administration of selol with opioids markedly enhanced the analgesic activity of all three investigated compounds.


CONCLUSIONS
Therefore, concomitant administration of selenium and opioids may be beneficial in terminal neoplastic states.
Bujalska
Magdalena
M
Department of Pharmacodynamics, Medical University of Warsaw, Warsaw, Poland. mbujalska@gmail.com
Gumułka
Stanisław Witold
SW