Effect of preoperative intravenous pantoprazole in elective-surgery patients: a pilot study.
BACKGROUND
This study evaluated the effects of intravenous pantoprazole on gastric volume and acid output in elective-surgical patients.


METHODS
This is a multicenter, randomized, pilot study of adult patients receiving intravenous pantoprazole: 40 mg every 24 h, 40 mg every 12 h (q12h) or 80 mg q12h. The first dose was administered 1 h before general anesthesia for surgery. All gastric fluid was aspirated through a nasogastric tube 1 h before dosing and through the postoperative period. Aspirate volume was recorded; pH and H(+) concentrations were measured.


RESULTS
Twenty-six patients were enrolled and 21 were evaluable. Pantoprazole was well tolerated. All regimens decreased gastric acid output and volume, and increased pH within 1 h of dosing. Effects were sustained for up to 12 h following single-dose administration.


CONCLUSIONS
Intravenous pantoprazole administered prior to anesthesia induction may be efficacious for the reduction of gastric volume and acid output, and for pulmonary aspiration prophylaxis in surgical patients.
Pisegna
Joseph R
JR
CURE: Digestive Diseases Research Center, University of California, Los Angeles, CA, USA. jpisegna@ucla.edu
Karlstadt
Robyn G
RG
Norton
Jeffrey A
JA
Fogel
Ronald
R
Oh
David S
DS
Jay Graepel
G
G
Dorr
Mary Beth
MB