Health-related quality of life for extremely low birth weight adolescents in Canada, Germany, and the Netherlands.
OBJECTIVE
The goal was to compare health-related quality of life of 12- to 16-year-old adolescents born at an extremely low birth weight in regional cohorts from Ontario (Canada), Bavaria (Germany), and the Netherlands.


METHODS
Patients were extremely low birth weight survivors from Canada, Germany, and the Netherlands. Health-related quality of life was assessed with Health Utilities Index 3. Missing data were substituted by proxy reports. Differences in mean Health Utilities Index 3 scores were tested by using analysis of variance. Differences in the numbers of children with affected attributes were tested by using logistic regression analyses.


RESULTS
Survival rates were similar; response rates varied between 71% and 90%. Significant differences in health-related quality of life were found between the cohorts, with Dutch children scoring highest on Health Utilities Index 3 and German children scoring lowest, independent of birth weight, gestational age, and cerebral palsy. Differences in mean utility scores were mainly attributable to differences in the cognition health attribute. Most of the results were corroborated by logistic regression analyses.


CONCLUSIONS
There were significant differences between the 3 cohorts in health-related quality of life, not related to differences in birth weight, gestational age, or cerebral palsy. Survival and response rates alone cannot explain these differences.
Verrips
Erik
E
TNO Prevention and Health, PO Box 2215, 2301 CE Leiden, Netherlands. erik.verrips@tno.nl
Vogels
Ton
T
Saigal
Saroj
S
Wolke
Dieter
D
Meyer
Renate
R
Hoult
Lorraine
L
Verloove-Vanhorick
S Pauline
SP