[The clinical findings and prognosis of 28 cases of intraocular lymphoma].
BACKGROUND
Although the prognosis of intraocular lymphoma has improved due to the recent progress in diagnosis, the survival prognosis of this disease remains unclear.


RESULTS
We reviewed the records of 28 patients (male/female ratio, 6/22) with intraocular lymphoma diagnosed and treated at Tokyo Medical University Hospital during the past 20 years. The mean age at presentation was 63.3 years. The mean follow-up period was 33.5 +/- 28.5 months (mean +/- SD). The most frequent presenting symptom was visual loss or blurred vision. On ophthalmological examination, the most common sign was vitreous opacity. Ocular disease concurrent with central nervous system (CNS) involvement was observed in 46.4%, while localized ocular disease was found in 25.0% of the patients. Intraocular lymphoma occurred as the primary lymphoma in 78.6%, and as ocular relapse of the primary CNS lymphoma in 14.3% of the cases. The 5-year survival rate was 63.1% and most of the deaths were in patients with CNS involvement.


CONCLUSIONS
Although the number of cases was limited, we were able to clarify the clinical manifestations and prognosis for Japanese patients with intraocular lymphoma.
Kimura
Keisuke
K
Department of Ophthalmology, Tokyo Medical University, Tokyo 160-0023, Japan.
Goto
Hiroshi
H