New N(4)-substituted piperazine naphthamide derivatives as BACE-1 inhibitors.
Synthesis and enzymatic evaluation of new series of N(4)-substituted piperazine naphthamide derivatives as BACE-1 inhibitors for the treatment of Alzheimer's disease are reported.
Laras
Y
Y
Laboratoire de Chimie Biomoleculaire, Faculte des Sciences Luminy, IBDML-UMR-6216-CNRS, Universite de la Mediterranee, Marseille Cedex, France.
Garino
C
C
Dessolin
J
J
Weck
C
C
Moret
V
V
Rolland
A
A
Kraus
J-L
JL