title: EEG sources in a group of patients with major depressive disorders.
abstract: EEG sources were assessed in a group of patients with major moderate-severe depressive disorder (MDD) as classified by trained clinicians according to DSM-IV criteria. Frequency Domain Variable Resolution Electromagnetic Tomography (FD-VARETA) was used to calculate EEG sources. The Z-values indicated that EEG sources were abnormal (increase in current density) in all patients, with most demonstrating abnormal EEG sources in both hemispheres but with maximal inverse solution located primarily in the right. Twenty-nine patients had a predominant topography of the abnormal EEG maximal inverse solution in the frontal lobes. The remaining seven patients had a bilateral abnormal increase in current density in the superior parietal lobe. The EEG maximal abnormal inverse solution frequency was observed in both hemispheres such that the increases in current density were prevalent in alpha and theta bands. The results suggest that any of the two hemispheres could be affected by MDD, but abnormal EEG sources can be found more frequently in the right one, with the maximal abnormal inverse solution at the alpha and theta bands in frontal and parietal cortices.
authors.affiliation: Dpto. de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus, Juriquilla, Querétaro, México. oojrg@yahoo.com
authors.forename: Josefina
authors.initials: J
authors.lastname: Ricardo-Garcell
authors.forename: Jorge J
authors.initials: JJ
authors.lastname: González-Olvera
authors.forename: Edgar
authors.initials: E
authors.lastname: Miranda
authors.forename: Thalía
authors.initials: T
authors.lastname: Harmony
authors.forename: Ernesto
authors.initials: E
authors.lastname: Reyes
authors.forename: Luis
authors.initials: L
authors.lastname: Almeida
authors.forename: Lídice
authors.initials: L
authors.lastname: Galán
authors.forename: Daniela
authors.initials: D
authors.lastname: Díaz
authors.forename: Lizeth
authors.initials: L
authors.lastname: Ramírez
authors.forename: Antonio
authors.initials: A
authors.lastname: Fernández-Bouzas
authors.forename: Eduardo
authors.initials: E
authors.lastname: Aubert