Chemical constituents from the leaves of Manglietia phuthoensis and their effects on osteoblastic MC3T3-E1 cells.
Two new phenyl glycosides, mangliesides A and B (1, 2), a new ionol glycoside, manglieside C (3), two new lignan glycosides, mangliesides D and E (4, 5), were isolated from the leaves of Manglietia phuthoensis, along with two known lignans, 3-methoxymagnolol (6) and obovatol (7). Their structures were established by means of 1D and 2D NMR, electrospray ionization (ESI)-MS and HR-ESI-MS experiments. Among them, compounds 2 and 5 significantly (p<0.05) increased the growth and differentiation of osteoblastic MC3T3-E1 cells in vitro.
Kiem
Phan Van
PV
Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology, Viet, Nghiado, Caugiay, Hanoi, Vietnam.
Tri
Mai Dinh
MD
Tuong
Le Vo Dinh
le VD
Tung
Nguyen Huu
NH
Hanh
Nguyen Ngoc
NN
Quang
Tran Hong
TH
Cuong
Nguyen Xuan
NX
Minh
Chau Van
CV
Choi
Eun-Mi
EM
Kim
Young Ho
YH