title: A simple, cost-effective method for the regioselective deuteration of anilines.
abstract: A highly effective and operationally simple method for the regioselective deuteration of anilines is presented. A variety of electron-rich and electron-deficient anilines are efficiently deuterated at the ortho and/or para position with respect to the nitrogen in the presence of 1 equiv of conc HCl in D 2O. Under the present conditions, aromatic methoxy groups do not facilitate deuteration, enabling a chemo- and regioselective deuteration of p-anisidine.
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada.
authors.forename: Andrew
authors.initials: A
authors.lastname: Martins
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens