[Effects of marine collagen peptide on delaying the skin aging].
OBJECTIVE
To investigate the protective effect of marine collagen peptides (MCPs) on the skin of aged mice induced by D-galactose.


METHODS
Subchronic toxicity study was conducted while D-galactose induced subacute aging model was established. D-galactose dose of 0.125 g/kg body weight was intraperitoneally injected daily for 90 days. Marine collagen peptide 0.225, 0.450, 1.350 g/kg body weight were administered by oral gavage. Superoxide dismutase (SOD), catalase (CAT) activity and malondialdehyde (MDA) content in blood serum were measured, along with cutaneous histopathology examination.


RESULTS
Epidermal thickness was significantly higher in MCPs treated group. Number and activity of fibroblast in MCPs treated dermis was increased prominently. The activity of SOD in 0.225, 0.450, 1.350 g/kgbw MCPs treated groups were 455.52 +/- 11.39, 460.15 +/- 18.09, 468.59 +/- 27.25 U/ml respectively, each of which was significantly higher than that in model control group; the activity of serum CAT in 0.225, 1.350 g/kgbw MCPs treated groups (21.33 +/- 4.82, 21.69 +/- 1.68 U/ml) were obviously increased compared with that in model control group (17.14 +/- 2.81 U/ml); MDA level in 0.450, 1.350 g/kgbw MCPs treated groups were 5.67 +/- 0.93, 5.76 +/- 1.02 nmol/ml respectively, each of which was significantly lower than that in model control group (7.63 +/- 1.37 nmol/ml).


CONCLUSIONS
The results showed that MCPs might play a protective role on skin aging by improving the activity of antioxidant.
Pei
Xin-rong
XR
Department of Food and Nutritional Hygiene, School of Public Health, Beijing University, Beijing 100083, China.
Yang
Rui-yue
RY
Zhang
Zhao-feng
ZF
Xu
Ya-jun
YJ
Han
Xiao-long
XL
Wang
Jun-bo
JB
Li
Yong
Y