title: Design and synthesis of fluorescent SGLT2 inhibitors.
abstract: The design and synthesis of the first fluorophore-conjugated SGLT2 inhibitors is described. The mode of linking the fluorophore to the SGLT2 pharmacophore was found to be crucial in achieving optimum potency. Superior potency to phlorizin was provided by examples containing TAMRA, BODIPY, Cy3B and NBD fluorophores.
authors.affiliation: Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Kent CT139NJ, UK. mark.lansdell@pfizer.com
authors.forename: Mark I
authors.initials: MI
authors.lastname: Lansdell
authors.forename: Denise J
authors.initials: DJ
authors.lastname: Burring
authors.forename: David
authors.initials: D
authors.lastname: Hepworth
authors.forename: Matthew
authors.initials: M
authors.lastname: Strawbridge
authors.forename: Emily
authors.initials: E
authors.lastname: Graham
authors.forename: Thierry
authors.initials: T
authors.lastname: Guyot
authors.forename: Mark S
authors.initials: MS
authors.lastname: Betson
authors.forename: James D
authors.initials: JD
authors.lastname: Hart