Arylamine N-acetyltransferases: a new inhibitor of apoptosis in HepG2 cells.
OBJECTIVE
To explore how arylamine N-acetyltransferases (NATs) is related to cell apoptosis.


METHODS
NAT activity in apoptotic HepG2 cells was measured using high performance liquid chromatography (HPLC); the apoptosis rate of HepG2 cells acted upon by an NAT inhibitor was measured using flow cytometry.


RESULTS
NAT activity was lowered in apoptotic HepG2 cells; apoptosis rate induced by camptothecin (CAM) increased after inhibition of NAT activity in HepG2 cells.


CONCLUSIONS
NAT can inhibit apoptosis in HepG2 cells.
Ji
Yu-bin
YB
Postdoctoral Research Station of the Institute of Materia Medica, Center for Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China.
Gao
Shi-yong
SY