Atypical teratoid/rhabdoid tumor arising from the third cranial nerve.
An otherwise healthy 6-week-old girl who presented with an isolated left third cranial nerve palsy underwent MRI that revealed an enhancing mass intrinsic to the left third cranial nerve. Rapid enlargement of the lesion over 1 month led to subtotal neurosurgical resection of an atypical teratoid/rhabdoid tumor (AT/RT), a rare, highly aggressive malignancy of infancy closely related histologically to medulloblastoma and primitive neuroectodermal tumor. Despite aggressive chemotherapy, the patient died within 6 months of presentation. This is the first report of an AT/RT presenting as an isolated third cranial nerve palsy caused by tumor arising from within the nerve.
Wykoff
Charles C
CC
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine and Miami Children's Hospital, Miami, Florida 33136, USA. cwykoff@med.miami.edu
Lam
Byron L
BL
Brathwaite
Carole D
CD
Biegel
Jaclyn A
JA
McKeown
Craig A
CA
Rosenblum
Marc K
MK
Allewelt
Heather B
HB
Sandberg
David I
DI