title: Cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia are correlated with Sokal risk scores and duration of therapy but not trough imatinib plasma levels.
abstract: Cytogenetic and molecular responses to standard-dose imatinib (IM) were correlated with trough IM plasma levels for 78 patients with chronic myeloid leukemia (CML) after a minimum of 12 months of IM therapy. The mean trough IM plasma level was 1065 ng/ml (range, 203-2910). There was no correlation of mean plasma trough IM levels and complete cytogenetic response (CCR) at 1 year (CCR 1010 ng/ml vs no CCR 1175 ng/ml P=.29) or major molecular response (MMR) (MMR1067 ng/ml vs no MMR 1063 ng/ml P=.74) after a median of 1298 days of IM therapy. CCR and MMR did correlate with Sokal risk scores with the odds of achieving CCR or MMR for a low risk vs high risk score of 10.8 (95% CI 2.2-53.5) and 6.4 (95% CI 1.4-29.4), respectively. Furthermore, a longer duration of IM therapy also was associated with a greater likelihood of achieving MMR (P=.02).
authors.affiliation: Leukemia/BMT Program of British Columbia, Division of Hematology, Vancouver General Hospital, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada. dforrest@bccancer.bc.ca
authors.forename: Donna L
authors.initials: DL
authors.lastname: Forrest
authors.forename: Shannon
authors.initials: S
authors.lastname: Trainor
authors.forename: Ryan R
authors.initials: RR
authors.lastname: Brinkman
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Barnett
authors.forename: Donna E
authors.initials: DE
authors.lastname: Hogge
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Nevill
authors.forename: John D
authors.initials: JD
authors.lastname: Shepherd
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Nantel
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Toze
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Sutherland
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Song
authors.forename: Julye C
authors.initials: JC
authors.lastname: Lavoie
authors.forename: Maryse M
authors.initials: MM
authors.lastname: Power
authors.forename: Yasser
authors.initials: Y
authors.lastname: Abou-Mourad
authors.forename: Clayton A
authors.initials: CA
authors.lastname: Smith