Out-of-equilibrium microrheology inside living cells.
Both forced and spontaneous motions of magnetic microbeads engulfed by Dictyostelium cells have served as experimental probes of intracellular dynamics. The complex shear modulus G*(omega), determined from active oscillatory measurements, has a power-law dynamics and increases with the probe size, reflecting intracellular structural complexity. The combined use of passive microrheology allows one to derive the power spectrum of active forces acting on intracellular phagosomes and to test the validity of the fluctuation-dissipation theorem inside living cells.
Wilhelm
Claire
C
Laboratoire Matière et Systèmes Complexes (MSC), UMR 7057, CNRS and University Paris Diderot, Paris, France. claire.wilhelm@univ-paris-diderot.fr