Target-driven selection in a dynamic nitrone library.
Nitrones undergo dynamic exchange in chloroform at room temperature through two mechanisms-hydrolysis and recombination or hydroxylamine addition/elimination; this dynamic exchange is harnessed to select a nitrone-based bis(amidopyridine) receptor for diacids from a group of four nitrones through its binding to a glutaric acid-based target.
Turega
Simon M
SM
EaStCHEM and Centre for Biomolecular Sciences, School of Chemistry, University of St Andrews, St Andrews, Fife, UK KY16 9ST.
Lorenz
Christiane
C
Sadownik
Jan W
JW
Philp
Douglas
D