title: [123I]FP-CIT SPET imaging in drug-induced Parkinsonism.
abstract: We assessed the status of dopamine nerve terminals in patients treated with dopamine receptor blocking agents (DRBAs) who had developed drug-induced parkinsonism (DIP). We performed [(123)I]FP-CIT SPET in 32 consecutive patients who were on DRBAs for at least 6 months and developed extrapyramidal signs. The UPDRS-III was used to assess clinical severity. Twenty-six age- and sex-matched healthy subjects served as control group. Putamen [(123)I]FP-CIT SPET binding was reduced in 14 and normal in the remaining 18 patients. There was no difference between the two groups for age, duration of DRBAs treatment, UPDRS III, tremor, rigidity, and bradykinesia subscores for upper and lower limbs. Conversely, symmetry of parkinsonian signs and presence bucco-linguo-masticatory dyskinesias were more frequent in individuals with normal tracer binding. Imaging of the dopamine transporter may help to identify subjects with DIP secondary to a loss of dopamine nerve terminals.
authors.affiliation: Dipartimento di Scienze Neurologiche e della Visione, Università di Verona, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Tinazzi
authors.forename: Sarah
authors.initials: S
authors.lastname: Ottaviani
authors.forename: Ioannis U
authors.initials: IU
authors.lastname: Isaias
authors.forename: Isabella
authors.initials: I
authors.lastname: Pasquin
authors.forename: Maria
authors.initials: M
authors.lastname: Steinmayr
authors.forename: Claudio
authors.initials: C
authors.lastname: Vampini
authors.forename: Manuela
authors.initials: M
authors.lastname: Pilleri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Moretto
authors.forename: Antonio
authors.initials: A
authors.lastname: Fiaschi
authors.forename: Nicola
authors.initials: N
authors.lastname: Smania
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Giorgetti
authors.forename: Angelo
authors.initials: A
authors.lastname: Antonini