Provincial distribution of three HIV-1 resistant polymorphisms (CCR5-Delta32, CCR2-64I, and SDF1-3' A) in China.
CCR5-Delta32, CCR2-64I, mutants in two chemokine receptors and SDF1-3'A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Delta 32 was observed. CCR2-64I and SDF1-3' A had reverse distribution cline from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. Important information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.
Xiao
J
J
Institute of Genetics, Fudan University, Shanghai, China. xiao-junhua@fudan.edu
Hu
F
F
Xu
H
H
Su
B
B
Jiang
Y
Y
Luo
J
J
Zhang
W
W
Tan
J
J
Jin
L
L
Lu
D
D