title: Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy.
abstract: We report on the outcome of intravenous high-dose immunoglobulin (IVIg) treatment in four children with narcolepsy and cataplexy, in whom the early diagnosis and the extreme disease severity were indications for this potentially efficacious therapy. One of four patients showed an objective and persistent improvement in clinical features during and after IVIg treatment. Our data partially support the recent report of the efficacy of IVIg treatment in early diagnosed narcolepsy with cataplexy and support the need for a controlled multicenter clinical trial on IVIg in narcolepsy.
authors.affiliation: Sleep Disorders Center, Dept. of Neurological Sciences, University of Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy. giuseppe.plazzi@unibo.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Plazzi
authors.forename: Francesca
authors.initials: F
authors.lastname: Poli
authors.forename: Christian
authors.initials: C
authors.lastname: Franceschini
authors.forename: Antonia
authors.initials: A
authors.lastname: Parmeggiani
authors.forename: Piero
authors.initials: P
authors.lastname: Pirazzoli
authors.forename: Filippo
authors.initials: F
authors.lastname: Bernardi
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mignot
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cicognani
authors.forename: Pasquale
authors.initials: P
authors.lastname: Montagna