title: Ampullary adenocarcinoma - differentiation matters.
abstract: The periampullary region gives rise to two main subtypes of adenocarcinoma that show either pancreatobiliary or intestinal differentiation. New data demonstrates that the histological subtype - more so than the anatomical location - is an important independent prognostic factor. This fuels the discussion about maintaining ampullary cancer as a separate entity.
authors.affiliation: Department of Surgery, University Hospital, Im Neuenheimer Feld, 69120 Heidelberg, Germany. Peter.Schirmacher@med.uni-heidelberg.de
authors.forename: Peter
authors.initials: P
authors.lastname: Schirmacher
authors.forename: Markus W
authors.initials: MW
authors.lastname: Büchler