title: Regulation of K(+) channels may enhance wound healing in the skin.
abstract: In the process of promoting wound healing, epidermal growth factor (EGF) activates protein kinase C, protein tyrosine kinase and ERK MAPK (mitogen-activated protein kinase). The activation of these mediators in signal pathways can regulate the operation of K(+) channels. In addition, the K(+) channel is involved with cell migration and proliferation, both of which are requisite for wound healing. Recent studies, although not conducted on skin wounds, have found that the K(+) channel is associated with wound healing and that wound healing can be promoted by regulating the K(+) channels. Therefore, the authors hypothesize that healing of skin wounds could be promoted by regulating K(+) channel distribution in skin keratinocytes or fibroblasts. We plan to conduct a study of the promotion of skin wound healing using K(+) channel regulators.
authors.affiliation: Department of Physiology, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea.
authors.forename: Dawon
authors.initials: D
authors.lastname: Kang
authors.forename: Tae Hyun
authors.initials: TH
authors.lastname: Choi
authors.forename: Kihwan
authors.initials: K
authors.lastname: Han
authors.forename: Daegu
authors.initials: D
authors.lastname: Son
authors.forename: Jun Hyung
authors.initials: JH
authors.lastname: Kim
authors.forename: Sang-Hyon
authors.initials: SH
authors.lastname: Kim
authors.forename: Jungbin
authors.initials: J
authors.lastname: Park