Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge.
A structure-activity relationship (SAR) study of bastadin 6 (1), a brominated tyrosine-derived metabolite from Indonesian marine sponge having a potent anti-angiogenic activity, was executed. The syntheses and their biological evaluation of the oxime-modified analogues and bromine-modified analogues revealed that both the oxime moieties and bromine atoms in bastadin 6 (1) play an important role to show the potent and selective anti-proliferative activity against human umbilical vein endothelial cells (HUVECs).
Kotoku
Naoyuki
N
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Hiramatsu
Atsushi
A
Tsujita
Hiroaki
H
Hirakawa
Yoichi
Y
Sanagawa
Mami
M
Aoki
Shunji
S
Kobayashi
Motomasa
M