title: Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment.
abstract: This study investigated the possibility of incorporating alpha-tocopherol (vitamin E) into poly(3hydroxybutyrate) (P(3HB))/Bioglass composites, which are being developed for bone tissue engineering matrices. P(3HB) films with 20 wt% Bioglass and 10 wt% vitamin E were prepared using the solvent casting technique. Addition of vitamin E significantly improved the hydrophilicity of the composites along with increasing the total protein adsorption. The presence of protein adsorbed on the composite surface was further confirmed using X-ray photoelectron spectroscopy analysis. Preliminary cell culture studies using MG-63 human osteoblasts showed that the addition of vitamin E in the P(3HB)/20 wt% Bioglass films significantly increased cell proliferation. The results achieved in this study confirmed the possibility of incorporating vitamin E as a suitable additive in P(3HB)/Bioglass composites to engineer the surface of the composites by promoting higher protein adsorption and increasing the hydrophilicity.
authors.affiliation: Department of Materials, Imperial College London, London SW7 2AZ, UK.
authors.forename: Superb K
authors.initials: SK
authors.lastname: Misra
authors.forename: Sheryl E
authors.initials: SE
authors.lastname: Philip
authors.forename: Wojciech
authors.initials: W
authors.lastname: Chrzanowski
authors.forename: Showan N
authors.initials: SN
authors.lastname: Nazhat
authors.forename: Ipsita
authors.initials: I
authors.lastname: Roy
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Knowles
authors.forename: Vehid
authors.initials: V
authors.lastname: Salih
authors.forename: Aldo R
authors.initials: AR
authors.lastname: Boccaccini