title: Two cases of multidrug-resistant human immunodeficiency virus infection treated with atazanavir and lopinavir/ritonavir combination therapy.
abstract: The combination of atazanavir (ATV) and lopinavir/ritonavir (LPV/RTV) with nucleoside reverse transcriptase inhibitors (NRTI) has been used as a salvage regimen for human immunodeficiency virus (HIV)-positive patients. In this paper, we discuss two cases of HIV-positive patients who had long histories of virological failure following a heavy treatment of antiretroviral drugs, but then achieved virological suppression with double-boosted protease inhibitor (PI) regimens. In patients with multiple genotypic resistance to PIs and NRTIs, virological suppression can be achieved with a combination of ATV plus LPV/RTV with an NRTI backbone. The two cases in this report suggest that a combination of ATV plus LPV/RTV could be a useful salvage regimen for the subset of HIV-positive patients with limited treatment options.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea.
authors.forename: Heekyoung
authors.initials: H
authors.lastname: Choi
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Jeong
authors.forename: Han Sung
authors.initials: HS
authors.lastname: Lee
authors.forename: Bum Sik
authors.initials: BS
authors.lastname: Chin
authors.forename: Suk Hoon
authors.initials: SH
authors.lastname: Choi
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Han
authors.forename: Myung Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Chang Oh
authors.initials: CO
authors.lastname: Kim
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Choi
authors.forename: Young Goo
authors.initials: YG
authors.lastname: Song
authors.forename: June Myung
authors.initials: JM
authors.lastname: Kim