Cathepsin D: a cellular roadmap.
Cathepsin D is a normal and major component of lysosomes, it is found in almost all cells and tissues of mammals. Present review describes different events in cellular life of cathepsin D mainly its biosynthesis, co-translational and posttranslational modifications, targeting to lysosomes and proteolytic processing and maturation within lysosomes.
Zaidi
Nousheen
N
Medical and Natural Sciences Research Centre, University of Tubingen, Ob dem Himmerlreich 7, 72074 Tubingen, Germany.
Maurer
Andreas
A
Nieke
Sebastian
S
Kalbacher
Hubert
H