title: Catalytic asymmetric conjugate addition of grignard reagents to alpha,beta-unsaturated sulfones.
abstract: A highly efficient method is reported for the asymmetric conjugate addition of Grignard reagents to alpha,beta-unsaturated 2-pyridylsulfones. Using a Cu/TolBinap complex, excellent enantioselectivities and high yields are obtained for a wide variety of aliphatic substrates.
authors.affiliation: Stratingh Institute for Chemistry,University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Pieter H
authors.initials: PH
authors.lastname: Bos
authors.forename: Adriaan J
authors.initials: AJ
authors.lastname: Minnaard
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa