title: Membrane redox state and apoptosis: death by peroxide.
abstract: Membrane redox state is governed by the complex interplay between oxidation of unsaturated fatty acids and lipophilic antioxidants. In this issue of Cell Metabolism, Seiler et al. (2008) show that a lipid oxidase, 12/15-lipoxygenase, and a membrane antioxidant enzyme, glutathione peroxidase-4, interact to regulate a novel redox-dependent cell death pathway.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Harvard Medical School, Boston, MA 02118-2394, USA. jloscalzo@rics.bwh.harvard.edu
authors.forename: Joseph
authors.initials: J
authors.lastname: Loscalzo