The cognitive effects of opioids in cancer: a systematic review.
OBJECTIVE
In order to better understand the effects of opioids on the cognitive function in cancer pain patients, a literature search was performed in PubMed, EMBASE, PsycInfo, CINAHL and Lilacs databases. Ten controlled trials were selected and classified according to the study design, the level of evidence, and opioid regimen.


RESULTS
Six studies reported association between poor cognitive performance (reaction time, attention, balance, and memory) and opioid use.


CONCLUSIONS
These cognitive deficits were captured with neuropsychological tests; however, their clinical relevance is still uncertain.
Kurita
Geana Paula
GP
Multidisciplinary Pain Centre, Dept. 7612, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. geana@rh.regionh.dk
Lundorff
Lena
L
Pimenta
Cibele Andrucioli de Mattos
CA
Sjøgren
Per
P