Asymmetric Michael addition of trisubstituted carbanion to nitroalkenes catalyzed by sodium demethylquinine salt in water.
A mild method for the asymmetric synthesis of quaternary and tertiary carbon centers has been developed through Michael addition of trisubstituted carbon nucleophile to nitroalkenes catalyzed by low loading sodium demethylquinine salt in water.
Chen
Fu-Xin
FX
State Key Laboratory of Applied Organic Chemistry, Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, Gansu 730000, China.
Shao
Cheng
C
Liu
Qian
Q
Gong
Pin
P
Liu
Chun-Liang
CL
Wang
Rui
R