title: Successful balloon-based radiofrequency ablation of a widespread early squamous cell carcinoma and high-grade dysplasia of the esophagus: a case report.
abstract: BACKGROUND
  For selected patients with high-grade dysplasia (HGD) and/or early esophageal squamous cell cancer (ESCC), endoscopic therapy represents a nonsurgical treatment option. For widespread lesions, however, current endoscopic treatment modalities (eg, endoscopic resection, argon plasma coagulation, photodynamic therapy) are associated with considerable drawbacks, of which esophageal stricturing is the most significant. Balloon-based radiofrequency (RF) ablation (HALO System) is a promising technology for endoscopic treatment of Barrett's esophagus, and may also play a role in treating widespread HGD and early ESCC.
  
  
  OBJECTIVE
  We describe a case report of balloon-based RF ablation for HGD and early ESCC.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Tertiary care institution, Academic Medical Center, Amsterdam, The Netherlands.
  
  
  METHODS
  A 66-year-old male with a 35-mm large, flat-type ESCC with surrounding HGD.
  
  
  METHODS
  Balloon-based RF ablation (HALO System).
  
  
  METHODS
  Endoscopic and histological eradication of HGD and ESCC, and adverse events.
  
  
  RESULTS
  RF ablation resulted in complete endoscopic and histological eradication of HGD and ESCC without adverse events such as dysphagia or esophageal narrowing.
  
  
  CONCLUSIONS
  Single patient report, limited follow-up.
  
  
  CONCLUSIONS
  This is the first report of balloon-based RF ablation for esophageal HGD and early ESCC. The treatment resulted in complete eradication of a 35-mm flat ESCC with no adverse events. This suggests that this ablation technique deserves further study for the management of widespread HGD or flat-type ESCC.
authors.affiliation: Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: Roos E
authors.initials: RE
authors.lastname: Pouw
authors.forename: Joep J
authors.initials: JJ
authors.lastname: Gondrie
authors.forename: Wouter L
authors.initials: WL
authors.lastname: Curvers
authors.forename: Carine M
authors.initials: CM
authors.lastname: Sondermeijer
authors.forename: Fiebo J
authors.initials: FJ
authors.lastname: Ten Kate
authors.forename: Jacques J
authors.initials: JJ
authors.lastname: Bergman