title: Significance of scintigraphy for the localisation of obscure gastrointestinal bleedings.
abstract: OBJECTIVE
  To determine the role of scintigraphy in patients with gastrointestinal (GI) bleeding of unknown localisation.
  
  
  METHODS
  We performed retrospective analyses on 92 patients receiving scintigraphies from 1993 to 2000 in the University of Regensburg hospital, which were done for localisation of GI bleeding as a diagnostic step after an unsuccessful endoscopy. In addition to the scintigraphies, further diagnostic steps such as endoscopy, angiography or operations were performed. In some of the scintigraphies with negative results, a provocation test for bleeding with heparinisation was carried out.
  
  
  RESULTS
  73% of all scintigraphies showed a positive result. In 4.5% of the positive results, the source was located in the stomach, in 37% the source was the small bowel, in 25% the source was the right colon, in 4.5% the source was the left colon, and in 20% no clear localisation was possible. Only 4% of all scintigraphies were false positive. A reliable positive scintigraphy was independent of the age of the examined patient. A provocation test for bleeding with heparin resulted in an additional 46% of positive scintigraphies with a reliable localisation in primary negative scintigraphies.
  
  
  CONCLUSIONS
  Our results show that scintigraphy and scintigraphy with heparin provocation tests are reliable procedures. They enable a reliable localisation in about half of the obscure GI-bleeding cases. Scintigraphy is superior to angiography in locating a bleeding. It is shown that even in the age of video capsule endoscopy and double-balloon enteroscopy, scintigraphy provides a reliable and directed localization of GI bleeding and offers carefully targeted guidance for other procedures.
authors.affiliation: Klinik und Poliklinik fuer Innere Medizin I, Klinikum der Universitat Regensburg, Regensburg, Germany. tanja.bruennler@klinik.uni-r.de
authors.forename: Tanja
authors.initials: T
authors.lastname: Brunnler
authors.forename: Frank
authors.initials: F
authors.lastname: Klebl
authors.forename: Sascha
authors.initials: S
authors.lastname: Mundorff
authors.forename: Christoph
authors.initials: C
authors.lastname: Eilles
authors.forename: Michael
authors.initials: M
authors.lastname: Reng
authors.forename: Hans
authors.initials: H
authors.lastname: von Korn
authors.forename: Jurgen
authors.initials: J
authors.lastname: Scholmerich
authors.forename: Julia
authors.initials: J
authors.lastname: Langgartner
authors.forename: Stefan
authors.initials: S
authors.lastname: Grune