Fungal cytochrome P450 database.
BACKGROUND
Cytochrome P450 enzymes play critical roles in fungal biology and ecology. To support studies on the roles and evolution of cytochrome P450 enzymes in fungi based on rapidly accumulating genome sequences from diverse fungal species, an efficient bioinformatics platform specialized for this super family of proteins is highly desirable.


RESULTS
The Fungal Cytochrome P450 Database (FCPD) archives genes encoding P450s in the genomes of 66 fungal and 4 oomycete species (4,538 in total) and supports analyses of their sequences, chromosomal distribution pattern, and evolutionary histories and relationships. The archived P450s were classified into 16 classes based on InterPro terms and clustered into 141 groups using tribe-MCL. The proportion of P450s in the total proteome and class distribution in individual species exhibited certain taxon-specific characteristics.


CONCLUSIONS
The FCPD will facilitate systematic identification and multifaceted analyses of P450s at multiple taxon levels via the web. All data and functions are available at the web site http://p450.riceblast.snu.ac.kr/.
Park
Jongsun
J
Fungal Bioinformatics Laboratory, Seoul National University, Seoul 151-921, Korea. starflr@snu.ac.kr
Lee
Seungmin
S
Choi
Jaeyoung
J
Ahn
Kyohun
K
Park
Bongsoo
B
Park
Jaejin
J
Kang
Seogchan
S
Lee
Yong-Hwan
YH