title: [Paliperidone--a novel second-generation antipsychotic].
abstract: Paliperidone Depot (PAL ER) is a new second-generation antipsychotic with pharmacodynamics resembling those of risperidone. PAL ER is slowly and smoothly released in 24 hours. Its half-life is about 24 hours. PAL is primarily eliminated unchanged in urine. Three short-term studies and one relapse study found PAL ER to be significantly more effective than placebo in all doses (3-15 mg once a day). There are no head-to-head comparisons with other antipsychotics, including risperidone. On the existing evidence it is not possible to ascertain whether PAL ER is better than risperidone in terms of effects and tolerability.
authors.affiliation: Region Hovedstaden Psykiatri, Psykiatrisk Center Glostrup, Glostrup.
authors.forename: Kamilla
authors.initials: K
authors.lastname: Maknyte
authors.forename: Henrik K F
authors.initials: HK
authors.lastname: Lublin