Cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia are correlated with Sokal risk scores and duration of therapy but not trough imatinib plasma levels.
Cytogenetic and molecular responses to standard-dose imatinib (IM) were correlated with trough IM plasma levels for 78 patients with chronic myeloid leukemia (CML) after a minimum of 12 months of IM therapy. The mean trough IM plasma level was 1065 ng/ml (range, 203-2910). There was no correlation of mean plasma trough IM levels and complete cytogenetic response (CCR) at 1 year (CCR 1010 ng/ml vs no CCR 1175 ng/ml P=.29) or major molecular response (MMR) (MMR1067 ng/ml vs no MMR 1063 ng/ml P=.74) after a median of 1298 days of IM therapy. CCR and MMR did correlate with Sokal risk scores with the odds of achieving CCR or MMR for a low risk vs high risk score of 10.8 (95% CI 2.2-53.5) and 6.4 (95% CI 1.4-29.4), respectively. Furthermore, a longer duration of IM therapy also was associated with a greater likelihood of achieving MMR (P=.02).
Forrest
Donna L
DL
Leukemia/BMT Program of British Columbia, Division of Hematology, Vancouver General Hospital, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada. dforrest@bccancer.bc.ca
Trainor
Shannon
S
Brinkman
Ryan R
RR
Barnett
Michael J
MJ
Hogge
Donna E
DE
Nevill
Thomas J
TJ
Shepherd
John D
JD
Nantel
Stephen H
SH
Toze
Cynthia L
CL
Sutherland
Heather J
HJ
Song
Kevin W
KW
Lavoie
Julye C
JC
Power
Maryse M
MM
Abou-Mourad
Yasser
Y
Smith
Clayton A
CA