New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.
A new route for the stereoselective synthesis of iodinated reboxetine analogues has been developed for the generation of SPECT imaging agents for the noradrenaline transporter (NAT). (2S,3S)- and (2R,3R)-iodoreboxetine were prepared and biological testing against various mono-amine transporters showed these compounds to be potent and selective for NAT.
Jobson
Nicola K
NK
WestChem, Department of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK.
Crawford
Andrew R
AR
Dewar
Deborah
D
Pimlott
Sally L
SL
Sutherland
Andrew
A