N-alkyl-5H-pyrido[4,3-b]indol-1-amines and derivatives as novel urotensin-II receptor antagonists.
High throughput screening of our compound collection led to the discovery of a novel series of N-alkyl-5H-pyrido[4,3-b]indol-1-amines as urotensin-II receptor antagonists. Synthesis, initial structure and activity relationships, functional and animal ortholog activities of the series are described.
Wang
Yonghui
Y
Oncology CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA. yonghui.2.wang@gsk.com <yonghui.2.wang@gsk.com>
Wu
Zining
Z
Guida
Brian F
BF
Lawrence
Sarah K
SK
Neeb
Michael J
MJ
Rivero
Ralph A
RA
Douglas
Stephen A
SA
Jin
Jian
J