title: Palladium-catalyzed method for the synthesis of carbazoles via tandem C-H functionalization and C-N bond formation.
abstract: The development of a new method for the assembly of unsymmetrical carbazoles is reported. The strategy involves the selective intramolecular functionalization of an arene C-H bond and the formation of a new arene C-N bond. The substitution pattern of the carbazole product can be controlled by the design of the biaryl amide substrate, and the method is compatible with a variety of functional groups. The utility of the new protocol was demonstrated by the concise synthesis of three natural products from commercially available materials.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA.
authors.forename: W C Peter
authors.initials: WC
authors.lastname: Tsang
authors.forename: Rachel H
authors.initials: RH
authors.lastname: Munday
authors.forename: Gordon
authors.initials: G
authors.lastname: Brasche
authors.forename: Nan
authors.initials: N
authors.lastname: Zheng
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald