title: Effectiveness and safety of loop electrosurgical excision procedure in a low-resource setting.
abstract: OBJECTIVE
  To evaluate the effectiveness and safety of the loop electrosurgical excision procedure (LEEP) to treat cervical intraepithelial neoplasia (CIN) in a low-resource setting.
  
  
  METHODS
  Women participating in a cervical screening study in India with histologically confirmed CIN unsuitable for cryotherapy were advised to undergo LEEP. One year after treatment the cervix was visually inspected with acetic acid, followed by colposcopy and biopsy taken from abnormal areas. Cure was defined as no clinical or histologic evidence of CIN. Factors influencing cure rates were evaluated by chi(2) tests.
  
  
  RESULTS
  Of the 311 women who underwent LEEP, 283 reported for 1-year follow-up and 248 (87.6%) were disease free. Cure rates were 93.0% for CIN 1, 85.5% for CIN 2, and 72.7% for CIN 3. Minor adverse effects were observed in 34 women and complications were seen in 5 women.
  
  
  CONCLUSIONS
  LEEP was associated with minimal complications and acceptable cure rates in a low-resource setting, although women with larger lesions had lower cure rates.
authors.affiliation: Division of Surgical Oncology, Regional Cancer Centre, Medical College Campus, Trivandrum, India.
authors.forename: Prabhakaran
authors.initials: P
authors.lastname: Rema
authors.forename: Sambasivan
authors.initials: S
authors.lastname: Suchetha
authors.forename: Somanathan
authors.initials: S
authors.lastname: Thara
authors.forename: Jean Marie
authors.initials: JM
authors.lastname: Fayette
authors.forename: Ramani
authors.initials: R
authors.lastname: Wesley
authors.forename: Rengaswamy
authors.initials: R
authors.lastname: Sankaranarayanan