Associations between baseline allergens and polysensitization.
BACKGROUND
Identification of patients at risk of developing polysensitization is not possible at present. An association between weak sensitizers and polysensitization has been hypothesized.


OBJECTIVE
To examine associations of 21 allergens in the European baseline series to polysensitization.


METHODS
From a database-based study with 14 998 patients patch tested with the European baseline series between 1985 and 2005, a group of 759 (5.1%) patients were polysensitized. Odds ratios were calculated to determine the relative contribution of each allergen to polysensitization.


RESULTS
Seven allergens--parabens mix, N-isopropyl-N-phenyl-p-phenylenediamine, sesquiterpene lactone mix, wool alcohols, potassium dichromate, Myroxylon pereirae, and cobalt chloride - showed statistically significant positive associations to polysensitization. Five allergens p-phenylenediamine, neomycin sulfate, epoxy resin, primin, and nickel sulfate showed statistically significant negative associations to polysensitization. For the allergens with the strongest associations, only every second individual with these particular allergies had two or more additional allergies.


CONCLUSIONS
No common denominator for the association between the allergens and the polysensitization was apparent, and any association, whether positive or negative, was relatively low. Based on these results, sensitization to specific baseline allergens cannot be used as risk indicators for polysensitization.
Carlsen
Berit Christina
BC
Department of Dermatology and Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, Ledreborg Allé 40, 1., 2820 Gentofte, Denmark. bccarlsen@dadlnet.dk
Menné
Torkil
T
Johansen
Jeanne Duus
JD