Research in motion: the enigma of Parkinson's disease pathology spread.
Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains. According to these studies, implanted neurons developed alpha-synuclein- and ubiquitin-positive Lewy bodies more than a decade after transplantation. We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease.
Brundin
Patrik
P
Neuronal Survival Unit, Department of Experimental Medical Science,Wallenberg Neuroscience Center, Lund University, SE-221 84 Lund, Sweden. Patrik.Brundin@med.lu.se
Li
Jia-Yi
JY
Holton
Janice L
JL
Lindvall
Olle
O
Revesz
Tamas
T