One-pot synthesis of benzofurans via palladium-catalyzed enolate arylation with o-bromophenols.
A one-pot synthesis of benzofurans which utilizes a palladium-catalyzed enolate arylation is described. The process demonstrates broad substrate scope and provides differentially substituted benzofurans in moderate to excellent yields. The utility of the method is further demonstrated by the synthesis of the natural product eupomatenoid 6 in three steps.
Eidamshaus
Christian
C
Merck Frosst Canada, 16711 Trans Canada Hwy., Kirkland, QC, Canada.
Burch
Jason D
JD