[Genetic variations in alcohol dehydrogenase, drinking habits and alcoholism].
Alcohol is degraded primarily by alcohol dehydrogenase (ADH), and genetic variation that affects the rate of alcohol degradation is found in ADH1B and ADH1C. By genotyping 9,080 white men and women from the general population, we found that men and women with ADH1B slow versus fast alcohol degradation drank approximately 30% more alcohol per week and had a higher risk of everyday and heavy drinking, and of alcoholism. Individuals with ADH1C slow versus fast alcohol degradation had a higher risk of heavy drinking.
Tolstrup
Janne S
JS
Syddansk Universitet, Center for Alkoholforskning, Statens Institut for Folkesundhed, København K. jst@niph.dk
Nordestgaard
Børge G
BG
Rasmussen
Søren
S
Tybjaerg-Hansen
Anne
A
Grønbaek
Morten
M