Structural determination of three new eudesmanolides from Inula helenium.
Ten sesquiterpenens were isolated from Inula helenium. Among them, three eudesmanolides: 15-hydroxy-11betaH-eudesm-4-en-8beta,12-olide (1), 3alpha-hydroxy-11betaH-eudesm-5-en-8beta,12-olide (2) and 2beta, 11alpha-dihydroxy-eudesm-5-en-8beta,12-olide (3) are new compounds. Their chemical structures were determined by spectral methods including 2D NMR.
Ma
Xiao-Chi
XC
School of Pharmaceutical Sciences, Dalian Medical University, Dalian 116027, PR China. maxc1978@sohu.com
Liu
Ke-Xin
KX
Zhang
Bao-Jing
BJ
Xin
Xiu-Lan
XL
Huang
Jian
J