title: Automated radiosynthesis of the Pittsburg compound-B using a commercial synthesizer.
abstract: BACKGROUND
  The Pittsburgh compound-B ([11C]PIB) is a highly interesting radiotracer for imaging amyloid plaques in Alzheimer's disease by positron emission tomography (PET). An increasing number of PET centres schedule its transfer for clinical studies and therefore are interested in its automated synthesis.
  
  
  METHODS
  With the aim of flexibility, we reported the first fully automated synthesis of [11C]PIB with the coupling of two commercial synthesizers.
  
  
  RESULTS
  [11C]PIB was prepared from 2-(4'-aminophenyl)-6-hydroxybenzothiazole by [11C]methyl triflate methylation reacting in an high-performance liquid chromatography loop and resulting in a total radiochemical yield of 13+/-15% after a synthesis time of 25 min. The specific activity of [11C]PIB was 20-60 GBq/micromol and its radiochemical purity is more than 99%.
  
  
  CONCLUSIONS
  The rapid synthesis and the automatic auto-cleaning procedure allow convenient and reproducible [11C]PIB synthesis to be performed during the same day for preclinical or clinical PET scans.
authors.affiliation: CERMEP-Imagerie du Vivant, PET Department, Université Lyon 1, Lyon, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Verdurand
authors.forename: Guillaume
authors.initials: G
authors.lastname: Bort
authors.forename: Vincent
authors.initials: V
authors.lastname: Tadino
authors.forename: Fréderic
authors.initials: F
authors.lastname: Bonnefoi
authors.forename: Didier
authors.initials: D
authors.lastname: Le Bars
authors.forename: Luc
authors.initials: L
authors.lastname: Zimmer