[Role of mitogen-activated protein kinase pathway in chloracne].
OBJECTIVE
To investigate the role of mitogen-activated protein kinase (MAPK) signal transduction pathway in chloracne.


METHODS
Immunohistochemical technique was used to detect the expression of phosphorylated epidermal growth factor receptor (p-EGFR) and p-MAPK proteins in the epithelium of chloracne group and control group.


RESULTS
p-EGFR and p-MAPK was found in all chloracne tissues, whereas no expression of p-EGFR and p-MAPK protein was found in control group. In the skin of chloracne patients, p-EGFR was mainly distributed in the membrane and the cytoplasm, especially in the vicinity of membrane; major positive signal of p-MAPK was in core and serosity.


CONCLUSIONS
EGFR and MAPK phosphorylation is found in chloracne tissues. MAPK signal transduction pathway is one important molecular mechanism of chloracne.
Zhang
Chun-mei
CM
Department of Occupational Health, School of PublicHealth, Tianjin Medical University, Tianjin 300070, China.
Tang
Nai-jun
NJ
Dong
Li
L
Zhao
Li-jun
LJ
Ma
Shi-wei
SW
Wei
Wen-guo
WG
Zhang
Wan-qi
WQ
Zhang
Peng
P
Han
Wei
W