title: Decision-making in patients with advanced cancer compared with amyotrophic lateral sclerosis.
abstract: OBJECTIVE
  Patients with advanced cancer need information about end-of-life treatment options in order to make informed decisions. Clinicians vary in the frequency with which they initiate these discussions.
  
  
  METHODS
  As part of a long-term longitudinal study, patients with an expected 2-year survival of less than 50% who had advanced gastrointestinal or lung cancer or amyotrophic lateral sclerosis (ALS) were interviewed. Each patient's medical record was reviewed at enrollment and at 3 months for evidence of the discussion of patient wishes concerning ventilator support, artificial nutrition and hydration (ANH), resuscitation (DNR) and hospice care. A Kaplan-Meier analysis was also performed and 2-year survival calculated.
  
  
  RESULTS
  60 cancer and 32 ALS patients were enrolled. ALS patients were more likely than cancer patients to have evidence of discussion about their wishes for ventilator support (31% vs 0%, p<0.001), ANH (38% vs 0%, p<0.001), DNR (25% vs 0%, p<0.001) and hospice care (22% vs 5%, p = 0.03). At 6 months, 91% of ALS patients were alive compared with 62% of cancer patients; at 2 years, 63% of ALS patients were alive compared with 23% of cancer patients (p<0.001).
  
  
  CONCLUSIONS
  Cancer patients were less likely than ALS patients to have had documented advanced care planning discussions despite worse survival. This may reflect perceptions that ALS has a more predictable course, that advanced cancer has a greater number of treatment options, or differing views about hope. Nevertheless, cancer patients may be less adequately prepared for end-of-life decision-making.
authors.affiliation: Maimonides Medical Center, Brooklyn, New York, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Astrow
authors.forename: J R
authors.initials: JR
authors.lastname: Sood
authors.forename: M T
authors.initials: MT
authors.lastname: Nolan
authors.forename: P B
authors.initials: PB
authors.lastname: Terry
authors.forename: L
authors.initials: L
authors.lastname: Clawson
authors.forename: J
authors.initials: J
authors.lastname: Kub
authors.forename: M
authors.initials: M
authors.lastname: Hughes
authors.forename: D P
authors.initials: DP
authors.lastname: Sulmasy