title: 5alpha-Androst-3-en-17-one oxime.
abstract: The title compound, C(19)H(29)NO, is a C17-oxime derivative of a potent aromatase inhibitor, which surprisingly has been found to have no inhibitory power. It crystallizes with two independent molecules in the asymmetric unit. C=N-O-H...N hydrogen bonds link pairs of molecules to form dimers almost parallel to the bc plane. Cohesion of the structure is also due to another three C-H...O hydrogen bonds directed along the a axis. This hydrogen-bonding scheme can be correlated to the almost complete loss of inhibitory power of the title compound.
authors.affiliation: CEMDRX, Departamento de Física, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, P-3004-516 Coimbra, Portugal. lourdes@pollux.fis.uc.pt
authors.forename: L C R
authors.initials: LC
authors.lastname: Andrade
authors.forename: M J M
authors.initials: MJ
authors.lastname: de Almeida
authors.forename: F M
authors.initials: FM
authors.lastname: Fernandes Roleira
authors.forename: C L
authors.initials: CL
authors.lastname: Varela
authors.forename: E J
authors.initials: EJ
authors.lastname: Tavares da Silva