Total synthesis of salinosporamide A.
The total synthesis of salinosporamide A has been achieved through enzymatic desymmetrization, diastereoselective aldol reaction, intramolecular aldol reaction, and intermolecular Reformatsky-type reaction followed by 1,4-reduction as key reactions.
Fukuda
Takeo
T
School of Pharmacy, Kitasato University, Kitasato Institute for Life Sciences, Kitasato University, and The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Sugiyama
Kouhei
K
Arima
Shiho
S
Harigaya
Yoshihiro
Y
Nagamitsu
Tohru
T
Omura
Satoshi
S