[Acyclovir-induced acute renal failure: An under-estimated secondary effect?].
The increasing use of oral or IV acyclovir to treat infections caused by herpesviridae family involves a rise in the number of observed adverse effects. Neuro- and nephrotoxicity are most serious observed and reported secondary effects. The monitoring of renal function is essential to detect these cases since it develops as a non-oliguric renal failure. Because of this, the outpatient and oral use of the drug can result in an underestimation of the number of cases reported. We report two patients with genital herpes and viral encephalitis that required IV acyclovir. Both inpatients developed an acute renal failure that resolved after the drug was withdrawn.
Vela-Enríquez
F
F
Servicio de Pediatría. Hospital de Poniente. El Ejido. Almería. España. fcove@msn.com
Sánchez-Vázquez
A R
AR
Cañabate-Reche
F
F
Vicente Pintor
A
A
Benavides Román
R
R