[Lipid peroxidation injury and endoplasmic reticulum stress in Al-induced apoptosis].
OBJECTIVE
To study the role of lipid peroxidation injury and endoplasmic reticulum stress in Al-induced apoptosis.


METHODS
Neurons from 0-3 day rats were cultured and treated with different concentrations of AlCl3.6H2O. Morphologic changes of neurons and endoplasmic reticulum were observed under fluorescent and transmission electron microscope; activities of superoxide dismutase (SOD), malondialdehyde (MDA) and ATP enzymes were detected.


RESULTS
Typical morphologic changes in neurons apoptosis and endoplasmic reticulum were found under fluorescent and transmission electron microscope; SOD enzyme viability and ATP enzyme viability were significantly increased in the low-dosage group, but reduced in mid and high-dosage group (P < 0.01), whereas MDA levels decreased in the low-dosage group, but increased in mid and high-dosage group (P < 0.01).


CONCLUSIONS
Aluminum may induce neurons apoptosis, and lipid peroxidation injury in endoplasmic reticulum plays an important role in the apoptosis progression.
Zhang
Qin-li
QL
Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
Wang
Fang
F
Shi
Ying-tao
YT
Wang
Lin-ping
LP
Zhang
Ling
L
Zhang
Hong-mei
HM
Wang
Jing
J
Li
Qiu-ying
QY
Niu
Qiao
Q