Eicosanoids in tumor progression and metastasis.
Eicosanoids and the enzymes responsible for their generation in living systems are involved in the mediation of multiple physiological and pathophysiological responses. These bioactive metabolites are part of complex cascades that initiate and perpetuate several disease processes such as atherosclerosis, arthritis, neurodegenerative conditions, and cancer. The intricate role played by each of these metabolites in the initiation, progression, and metastasis of solid tumors has been a subject of intense research in the scientific community. This review summarizes some of the key aspects of eicasonoids and the associated enzymes, and the pathways they mediate in promoting tumor progression and metastasis.
Krishnamoorthy
Sriram
S
Departments of Pathology, and Chemistry, Wayne State University School of Medicine, Detroit, MI 48202, USA.
Honn
Kenneth V
KV