Cerebral and autonomic responses to emotional facial expressions in depersonalisation disorder.
BACKGROUND
Depersonalisation disorder is characterised by emotion suppression, but the cerebral mechanisms of this symptom are not yet fully understood.


OBJECTIVE
To compare brain activation and autonomic responses of individuals with the disorder and healthy controls.


METHODS
Happy and sad emotion expressions in increasing intensities (neutral to intense) were presented in an implicit event-related functional magnetic resonance imaging (fMRI) design with simultaneous measurement of autonomic responses.


RESULTS
Participants with depersonalisation disorder showed fMRI signal decreases, whereas the control group showed signal increases in response to emotion intensity increases in both happy and sad expressions. The analysis of evoked haemodynamic responses from regions exhibiting functional connectivity between central and autonomic nervous systems indicated that in depersonalisation disorder initial modulations of haemodynamic response occurred significantly earlier (2 s post-stimulus) than in the control group (4-6 s post-stimulus).


CONCLUSIONS
The results suggest that fMRI signal decreases are possible correlates of emotion suppression in depersonalisation disorder.
Lemche
Erwin
E
Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. e.lemche@iop.kcl.ac.uk
Anilkumar
Ananthapadmanabha
A
Giampietro
Vincent P
VP
Brammer
Michael J
MJ
Surguladze
Simon A
SA
Lawrence
Natalia S
NS
Gasston
David
D
Chitnis
Xavier
X
Williams
Steven C R
SC
Sierra
Mauricio
M
Joraschky
Peter
P
Phillips
Mary L
ML