Short, stereoselective synthesis of the naturally occurring pyrrolidine radicamine B and a formal synthesis of nectrisine.
A short, stereoselective synthesis of the naturally occurring pyrrolidine radicamine B is reported. Garner's (R)-aldehyde, prepared from D-serine, was the chiral starting material. The pyrrolidine ring was stereoselectively created in a very efficient way through a five-step, one-pot transformation. In addition, an intermediate of this synthesis was transformed into an intermediate of a previously published synthesis of the potent alpha-glucosidase inhibitor nectrisine.
Ribes
Celia
C
Departamento de Química Inorgánica y Orgánica, Univ. Jaume I, E-12071 Castellón, Spain.
Falomir
Eva
E
Carda
Miguel
M
Marco
J Alberto
JA