Steroidal saponins from the roots of Smilax aspera subsp. mauritanica.
Two new steroidal saponins (1, 2) were isolated from the roots of Smilax aspera subsp. mauritanica (POIR.) ARCANG. (Liliaceae), together with the known curillin G (3), asparagoside E (4), asparoside A (5), asparoside B (6) and the phenolic compound resveratrol (7). Their structures were established mainly on the basis of 600 MHz 2D-NMR spectral data. 3 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (minimum inhibitory concentrations of 25, 25 and 50 microg/ml, respectively) whereas the other compounds were inactive.
Belhouchet
Zineddine
Z
Laboratoire de Pharmacognosie, Unité UMIB UPRES-EA, Faculté de Pharmacie, Université de Bourgogne, Dijon Cedex, France.
Sautour
Marc
M
Miyamoto
Tomofumi
T
Lacaille-Dubois
Marie-Aleth
MA