title: Oversulfated chondroitin sulfate: impact of a heparin impurity, associated with adverse clinical events, on low-molecular-weight heparin preparation.
abstract: Heparin, a widely used anticoagulant, is being rapidly displaced by low-molecular-weight heparins. Recently, certain lots of heparin have been associated with anaphylactoid-type reactions resulting from contamination with oversulfated chondroitin sulfate. This impurity has also contaminated low-molecular-weight heparins obtained by chemical and enzymatic depolymerization of heparin. The sensitivity of oversulfated chondroitin sulfate to five different depolymerization processes similar to ones used in preparing low-molecular-weight heparins is reported.
authors.affiliation: Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.
authors.forename: Zhenqing
authors.initials: Z
authors.lastname: Zhang
authors.forename: Michel
authors.initials: M
authors.lastname: Weïwer
authors.forename: Boyangzi
authors.initials: B
authors.lastname: Li
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Kemp
authors.forename: Tyler H
authors.initials: TH
authors.lastname: Daman
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Linhardt