title: Provincial distribution of three HIV-1 resistant polymorphisms (CCR5-Delta32, CCR2-64I, and SDF1-3' A) in China.
abstract: CCR5-Delta32, CCR2-64I, mutants in two chemokine receptors and SDF1-3'A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Delta 32 was observed. CCR2-64I and SDF1-3' A had reverse distribution cline from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. Important information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.
authors.affiliation: Institute of Genetics, Fudan University, Shanghai, China. xiao-junhua@fudan.edu
authors.forename: J
authors.initials: J
authors.lastname: Xiao
authors.forename: F
authors.initials: F
authors.lastname: Hu
authors.forename: H
authors.initials: H
authors.lastname: Xu
authors.forename: B
authors.initials: B
authors.lastname: Su
authors.forename: Y
authors.initials: Y
authors.lastname: Jiang
authors.forename: J
authors.initials: J
authors.lastname: Luo
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Tan
authors.forename: L
authors.initials: L
authors.lastname: Jin
authors.forename: D
authors.initials: D
authors.lastname: Lu