Two cases of multidrug-resistant human immunodeficiency virus infection treated with atazanavir and lopinavir/ritonavir combination therapy.
The combination of atazanavir (ATV) and lopinavir/ritonavir (LPV/RTV) with nucleoside reverse transcriptase inhibitors (NRTI) has been used as a salvage regimen for human immunodeficiency virus (HIV)-positive patients. In this paper, we discuss two cases of HIV-positive patients who had long histories of virological failure following a heavy treatment of antiretroviral drugs, but then achieved virological suppression with double-boosted protease inhibitor (PI) regimens. In patients with multiple genotypic resistance to PIs and NRTIs, virological suppression can be achieved with a combination of ATV plus LPV/RTV with an NRTI backbone. The two cases in this report suggest that a combination of ATV plus LPV/RTV could be a useful salvage regimen for the subset of HIV-positive patients with limited treatment options.
Choi
Heekyoung
H
Department of Internal Medicine, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea.
Jeong
Su Jin
SJ
Lee
Han Sung
HS
Chin
Bum Sik
BS
Choi
Suk Hoon
SH
Han
Sang Hoon
SH
Kim
Myung Soo
MS
Kim
Chang Oh
CO
Choi
Jun Yong
JY
Song
Young Goo
YG
Kim
June Myung
JM