Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands.
A series of non-imidazole histamine H(3) receptor antagonists based on the (3-phenoxypropyl)amine motif, which is a common pharmacophore for H(3) antagonists, has been identified. A preliminary SAR study around the amine moiety has identified 8a as a potent H(3) antagonist possessing a good pharmacokinetic profile in the rat.
Aslanian
Robert
R
The Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033-1300, USA. robert.aslanian@spcorp.com
Zhu
Xiaohong
X
Vaccaro
Henry A
HA
Shih
Neng-Yang
NY
Piwinski
John J
JJ
Williams
Shirley M
SM
West
Robert E
RE