[Current preclinical knowledge of the neurobiology of cocaine].
Repeated cocaine administration induces numerous neuroadaptations. Cocaine controls many neurotransmitter systems, including glutamate, GABA, dopamine, serotonin, and noradrenalin. Cocaine exposure modifies neuron morphology. Peptide systems such as the orexins probably play a key role in cocaine's long-term effects. The opioid system may be involved in cocaine's long-term effects. The complexity and the multiplicity of the neuroadaptations observed with cocaine may explain the current absence of effective pharmacotherapy.
Noble
Florence
F
Université Paris Descartes, faculté de pharmacie, Paris F-75006, France. florence.noble@univ-paris5.fr