title: In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.
abstract: Diverse polyfunctionalized quinolines, easily prepared using Lewis acid-catalyzed imino Diels-Alder reactions between corresponding aldimines, were tested for antifungal properties against standardized as well as clinical isolates of clinically important fungi. Among them, 4-pyridyl derivatives displayed the best activities mainly against dermatophytes. The activity appears not to be related neither to the lipophilicity nor to the basicity of compounds.
authors.affiliation: Laboratorio de Química Orgánica y Biomolecular, Escuela de Química, Universidad Industrial de Santander, A.A. 678, Bucaramanga, Colombia.
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Meléndez Gómez
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Kouznetsov
authors.forename: Maximiliano A
authors.initials: MA
authors.lastname: Sortino
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Alvarez
authors.forename: Susana A
authors.initials: SA
authors.lastname: Zacchino