Calcium-channel antagonists inhibit marble-burying behavior in mice.
In the present study, we examined the effects of calcium-channel antagonists on marble-burying behavior, which is an animal model of obsessive-compulsive disorder. Amlodipine (10 mg/kg, i.p.), cilnidipine (10 mg/kg, i.p.), nilvadipine (3 and 10 mg/kg, i.p.), and flunarizine (30 mg/kg, i.p.) significantly inhibited marble-burying behavior in mice. These results suggest that calcium channels may be involved in the marble-burying behavior.
Egashira
Nobuaki
N
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan. n-egashi@pharm.med.kyushu-u.ac.jp
Okuno
Ryoko
R
Abe
Moe
M
Matsushita
Michihiko
M
Mishima
Kenichi
K
Iwasaki
Katsunori
K
Oishi
Ryozo
R
Nishimura
Ryoji
R
Matsumoto
Yoshiaki
Y
Fujiwara
Michihiro
M