title: Submembraneous microtubule cytoskeleton: regulation of microtubule assembly by heterotrimeric Gproteins.
abstract: Heterotrimeric Gproteins participate in signal transduction by transferring signals from cell surface receptors to intracellular effector molecules. Gproteins also interact with microtubules and participate in microtubule-dependent centrosome/chromosome movement during cell division, as well as neuronal differentiation. In recent years, significant progress has been made in our understanding of the biochemical/functional interactions between Gprotein subunits (alpha and betagamma) and microtubules, and the molecular details emerging from these studies suggest that alpha and betagamma subunits of Gproteins interact with tubulin/microtubules to regulate the assembly/dynamics of microtubules, providing a novel mechanism for hormone- or neurotransmitter-induced rapid remodeling of cytoskeleton, regulation of the mitotic spindle for centrosome/chromosome movements in cell division, and neuronal differentiation in which structural plasticity mediated by microtubules is important for appropriate synaptic connections and signal transmission.
authors.affiliation: Department of Biological Sciences, University of Texas, El Paso, TX, USA. sukla@utep.edu
authors.forename: Sukla
authors.initials: S
authors.lastname: Roychowdhury
authors.forename: Mark M
authors.initials: MM
authors.lastname: Rasenick