Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy.
We report on the outcome of intravenous high-dose immunoglobulin (IVIg) treatment in four children with narcolepsy and cataplexy, in whom the early diagnosis and the extreme disease severity were indications for this potentially efficacious therapy. One of four patients showed an objective and persistent improvement in clinical features during and after IVIg treatment. Our data partially support the recent report of the efficacy of IVIg treatment in early diagnosed narcolepsy with cataplexy and support the need for a controlled multicenter clinical trial on IVIg in narcolepsy.
Plazzi
Giuseppe
G
Sleep Disorders Center, Dept. of Neurological Sciences, University of Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy. giuseppe.plazzi@unibo.it
Poli
Francesca
F
Franceschini
Christian
C
Parmeggiani
Antonia
A
Pirazzoli
Piero
P
Bernardi
Filippo
F
Mignot
Emmanuel
E
Cicognani
Alessandro
A
Montagna
Pasquale
P