title: The effects of the spatial influence function on orthotropic femur remodelling.
abstract: The morphology and internal structure of bone are modulated by the mechanical stimulus. The osteocytes can sense the stimulus signals from the adjacent regions and respond to them through bone growth or bone absorption. This mechanism can be modelled as the spatial influence function (SIF) in bone adaptation algorithm. In this paper, the remodelling process was simulated in human femurs using an adaptation algorithm with and without SIF, and the trabecular bone was assumed to be orthotropic. A different influence radius and weighting factor were adopted to study the effects of the SIF on the bone density distribution and trabecular alignment. The results have shown that the mean density and L-T ratio (the ratio of longitudinal modulus to transverse modulus) had an excellent linear relationship with the weighting factor when the influence radius was small. The characteristics of density distribution and L-T ratio accorded with the actual observation or measurement when a small weighting factor was used. The large influence radius and weighting factor led to unrealistic results. In contrast, the SIF hardly affected the trabecular alignment, as the mean variation angles of principal axes were less than 1.0 degree for any influence radius and weighting factor.
authors.affiliation: Department of Biomedical Engineering, Tsinghua University, Beijing, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Shang
authors.forename: J
authors.initials: J
authors.lastname: Bai
authors.forename: L
authors.initials: L
authors.lastname: Peng