title: Click chemistry for high-density biofunctionalization of mesoporous silica.
abstract: The applicability of click chemistry for high-density functionalization of mesoporous silica is demonstrated. The mild conditions of the copper(I)-catalyzed Huisgen reaction allow for a surface functionalization with intact biomolecules. The high covalent enzyme functionalization density under simultaneous retention of enzyme activity and the absence of leaching demonstrate the promising potential of this approach.
authors.affiliation: Department of Chemistry and Biochemistry, Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstr. 5-13 (E), 81377 Munich, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Schlossbauer
authors.forename: David
authors.initials: D
authors.lastname: Schaffert
authors.forename: Johann
authors.initials: J
authors.lastname: Kecht
authors.forename: Ernst
authors.initials: E
authors.lastname: Wagner
authors.forename: Thomas
authors.initials: T
authors.lastname: Bein