title: Effect of angiotensin converting enzyme inhibitors and beta-blockers on left ventricular remodeling after coronary artery bypass graft surgery.
abstract: Preventing left ventricular (LV) remodeling after coronary artery bypass graft surgery (CABG) is important to avoid long-term congestive heart failure. The present study evaluated the effects of angiotensin converting enzyme inhibitors (ACEIs) and beta-blockers on LV remodeling. Twenty-three patients with angina pectoris and 36 with old myocardial infarction underwent CABG. We assessed end diastolic volume index (EDVI), end systolic volume index (ESVI), and ejection fraction (EF) using left ventriculography before and after CABG. Changes in EDVI, ESVI, and EF were studied in the ACEI, beta-blocker, and control groups. Although EDVI was reduced in the ACEI group, ESVI and EF improved only slightly, whereas in the group given beta-blockers, ESVI was reduced, EF improved, and EDVI was minimally reduced. These results indicate that ACEIs and beta-blockers both protect against LV remodeling, although through different mechanisms.
authors.affiliation: Department of Health Promotion, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Maruyama
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Masaki
authors.forename: Shunichi
authors.initials: S
authors.lastname: Sato
authors.forename: Masato
authors.initials: M
authors.lastname: Kirimura
authors.forename: Kentaro
authors.initials: K
authors.lastname: Toyama
authors.forename: Mikio
authors.initials: M
authors.lastname: Yuhara
authors.forename: Osamu
authors.initials: O
authors.lastname: Sasaki
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kamiyama
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Nishioka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ito
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yoshimoto