Success of ampicillin plus ceftriaxone rescue therapy for a relapse of Enterococcus faecalis native-valve endocarditis and in vitro data on double beta-lactam activity.
We report a patient with Enterococcus faecalis native-valve endocarditis who relapsed after 4 weeks of treatment with ampicillin plus gentamicin. The relapse was cured with ampicillin plus ceftriaxone, which was introduced after gentamicin-induced acute renal failure. This double beta-lactam combination showed a bactericidal effect in time-killing curve studies.
Miro
Jose M
JM
Infectious Diseases Service, Hospital Clinic, Helios Building, Desk no. 26, Villarroel 170, 08036 Barcelona, Spain. jmmiro@ub.edu
Cervera
Carlos
C
Garcia-de-la-Maria
Cristina
C
Del Rio
Ana
A
Armero
Yolanda
Y
Mestres
Carlos A
CA
Grau
Jose M
JM
Marco
Francesc
F
Moreno
Asuncion
A