title: Copper-catalyzed oxidative coupling of benzylic C-H bonds with 1,3-dicarbonyl compounds.
abstract: A copper-catalyzed oxidative coupling of benzylic C-H bonds with 1,3-dicarbonyl compounds is described. The reaction utilizes an inexpensive copper catalyst-oxidant system that is suitable for the coupling of a range of benzylic C-H bonds with various 1,3-dicarbonyl compounds. Kinetic isotope studies support a mechanism involving a benzylic hydrogen abstraction.
authors.affiliation: Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Québec H9H 3L1, Canada.
authors.forename: Nadine
authors.initials: N
authors.lastname: Borduas
authors.forename: David A
authors.initials: DA
authors.lastname: Powell