MAP estimation algorithm for phase response curves based on analysis of the observation process.
Many research groups have sought to measure phase response curves (PRCs) from real neurons. However, methods of estimating PRCs from noisy spike-response data have yet to be established. In this paper, we propose a Bayesian approach for estimating PRCs. First, we analytically obtain a likelihood function of the PRC from a detailed model of the observation process formulated as Langevin equations. Then we construct a maximum a posteriori (MAP) estimation algorithm based on the analytically obtained likelihood function. The MAP estimation algorithm derived here is equivalent to the spherical spin model. Moreover, we analytically calculate a marginal likelihood corresponding to the free energy of the spherical spin model, which enables us to estimate the hyper-parameters, i.e., the intensity of the Langevin force and the smoothness of the prior.
Ota
Keisuke
K
Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259-G5-17 Nagatsuda-cho, Midori-ku, Yokohama, Kanagawa 226-8502, Japan. keisuke@acs.dis.titech.ac.jp
Omori
Toshiaki
T
Aonishi
Toru
T