Regulation of macrophage adhesion and migration by Rho GTP-binding proteins.
The Rho family proteins Rac and Rho are believed to be key regulators of cell migration through their effects on the cytoskeleton and cell adhesion. However, recent studies in macrophages indicate that they are not always essential for migration, although they do affect cell shape and adhesion.
Ridley
A J
AJ
Randall Division of Cell and Molecular Biophysics, New Hunt's House, King's College London, Guy's Campus, London, UK. anne.ridley@kcl.ac.uk