title: Total synthesis of dispyrin, purpurealidin E, and aplysamine-1.
abstract: Bromotyrosine alkaloids dispyrin (1), purpurealidin E (2), and aplysamine-1 (3) isolated from marine sponge, were synthesized from commercially available tyramine (4) as a common starting material. The overall yield was 18%, 39%, and 22% for 1 from 4 in 5 steps, 2 in 5 steps, and 3 in 6 steps, respectively.
authors.affiliation: Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Yoshida
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yamaguchi