Protective effect of trapidil on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury.
OBJECTIVE
Trapidil is an antianginal compound with a broad spectrum of pharmacological activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. We evaluated the effect of trapidil on the long-term histologic damage in testicular ischemia-reperfusion injury.


METHODS
Adult male Wistar rats were divided into three groups of six rats each. One group underwent 2 h of testicular torsion; one received pretreatment with trapidil before detorsion; and one group underwent sham operation. All rats underwent bilateral orchiectomy 60 days after the experiment. The mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score were determined by histological examination of each testis.


RESULTS
Testicular torsion-detorsion caused a significant decrease in the mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score in the ipsilateral testes, but not in the contralateral testes. The animals treated with trapidil had a significant increase in these histological parameters as compared to the torsion-detorsion group.


CONCLUSIONS
Trapidil administration before reperfusion may have the potential to decrease the long-term histologic damage that occurs after experimental testicular torsion. Trapidil is used as an antianginal drug and additional clinical studies are required to elucidate the protective role of trapidil in patients with testicular torsion.
Bozlu
Murat
M
Department of Urology, University of Mersin School of Medicine, Zeytinlibahce Caddesi, 33079, Mersin, Turkey. muratbozlu@yahoo.com
Acar
Deniz
D
Cayan
Selahittin
S
Aktas
Savas
S
Tunckiran
Ahmet
A