title: Comparison between confocal scanning laser tomography, scanning laser polarimetry and optical coherence tomography on the ability to detect localised retinal nerve fibre layer defects in glaucoma patients.
abstract: OBJECTIVE
  To compare the ability of confocal scanning laser tomography (CSLT), scanning laser polarimetry (SLP) and optical coherence tomography (OCT) in recognising localised retinal nerve fibre layer (RNFL) defects.
  
  
  METHODS
  51 eyes from 43 patients with glaucoma were identified by two observers as having RNFL defects visible on optic disc photographs. 51 eyes of 32 normal subjects were used as controls. Three masked observers evaluated CSLT, SLP and OCT images to determine subjectively the presence of localised RNFL defects.
  
  
  RESULTS
  Interobserver agreement was highest with OCT, followed by SLP and CSLT (mean kappa: 0.83, 0.69 and 0.64, respectively). RNFL defects were identified in 58.8% of CSLT, 66.7% of SLP and 54.9% of OCT (p = 0.02 between SLP and OCT) by at least two observers. In the controls, 94.1% of CSLT, 84.3% of SLP and 94.1% of OCT scans, respectively, were rated as normal (p = 0.02 between CSLT and SLP, and SLP and OCT).
  
  
  CONCLUSIONS
  Approximately 20-40% of localised RNFL defects identified by colour optic disc photographs are not detected by CSLT, SPL or OCT. SLP showed a higher number of false-positive results than the other techniques, but also had a higher proportion of correctly identified RNFL defects in the glaucoma population.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: B K
authors.initials: BK
authors.lastname: Windisch
authors.forename: P J
authors.initials: PJ
authors.lastname: Harasymowycz
authors.forename: J L
authors.initials: JL
authors.lastname: See
authors.forename: B C
authors.initials: BC
authors.lastname: Chauhan
authors.forename: A C
authors.initials: AC
authors.lastname: Belliveau
authors.forename: D M
authors.initials: DM
authors.lastname: Hutchison
authors.forename: M T
authors.initials: MT
authors.lastname: Nicolela