title: Effect of preoperative intravenous pantoprazole in elective-surgery patients: a pilot study.
abstract: BACKGROUND
  This study evaluated the effects of intravenous pantoprazole on gastric volume and acid output in elective-surgical patients.
  
  
  METHODS
  This is a multicenter, randomized, pilot study of adult patients receiving intravenous pantoprazole: 40 mg every 24 h, 40 mg every 12 h (q12h) or 80 mg q12h. The first dose was administered 1 h before general anesthesia for surgery. All gastric fluid was aspirated through a nasogastric tube 1 h before dosing and through the postoperative period. Aspirate volume was recorded; pH and H(+) concentrations were measured.
  
  
  RESULTS
  Twenty-six patients were enrolled and 21 were evaluable. Pantoprazole was well tolerated. All regimens decreased gastric acid output and volume, and increased pH within 1 h of dosing. Effects were sustained for up to 12 h following single-dose administration.
  
  
  CONCLUSIONS
  Intravenous pantoprazole administered prior to anesthesia induction may be efficacious for the reduction of gastric volume and acid output, and for pulmonary aspiration prophylaxis in surgical patients.
authors.affiliation: CURE: Digestive Diseases Research Center, University of California, Los Angeles, CA, USA. jpisegna@ucla.edu
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Pisegna
authors.forename: Robyn G
authors.initials: RG
authors.lastname: Karlstadt
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Norton
authors.forename: Ronald
authors.initials: R
authors.lastname: Fogel
authors.forename: David S
authors.initials: DS
authors.lastname: Oh
authors.forename: G
authors.initials: G
authors.lastname: Jay Graepel
authors.forename: Mary Beth
authors.initials: MB
authors.lastname: Dorr