title: Pontin and reptin, two related ATPases with multiple roles in cancer.
abstract: Studies in model organisms or cultured human cells suggest potential implications in carcinogenesis for the AAA+ ATPases Pontin and Reptin. Both proteins are associated with several chromatin-remodeling complexes and have many functions including transcriptional regulation, DNA damage repair, and telomerase activity. They also interact with major oncogenic actors such as beta-catenin and c-myc and regulate their oncogenic function. We only now begin to get insight into the role of Pontin and Reptin in human cancers.
authors.affiliation: Department of Laboratory Medicine and Pathobiochemistry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Otmar
authors.initials: O
authors.lastname: Huber
authors.forename: Ludovic
authors.initials: L
authors.lastname: Ménard
authors.forename: Valérie
authors.initials: V
authors.lastname: Haurie
authors.forename: Alexandra
authors.initials: A
authors.lastname: Nicou
authors.forename: Danièle
authors.initials: D
authors.lastname: Taras
authors.forename: Jean
authors.initials: J
authors.lastname: Rosenbaum