title: Lateralization of 17beta-hydroxysteroid dehydrogenase type 10 in hippocampi of demented and psychotic people.
abstract: OBJECTIVE
  The multifunctional mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 could play a role in the development of Alzheimer disease via its high-affinity binding to amyloid-beta peptides and its overexpression.
  
  
  METHODS
  We evaluated the specificity of alterations in mRNA/enzyme expression levels in human right and left hippocampi.
  
  
  RESULTS
  We observed a trend towards right/left laterality in nondemented nonpsychotic controls; however, the degree of asymmetry was higher for mRNA when compared to enzyme expression levels. In Alzheimer disease and schizophrenia, significant shifts to left/right asymmetry were found and the changes were associated with more marked increases in mRNA/enzyme expression in the left hemisphere. On the other hand, no alterations were observed in people with multi-infarct dementia.
  
  
  CONCLUSIONS
  Our results support studies reporting an impairment of mitochondria in Alzheimer disease or schizophrenia and a higher vulnerability of the dominant hemisphere to pathological processes. Overexpression of the enzyme could be used to distinguish Alzheimer disease from multi-infarct dementia.
authors.affiliation: Alzheimer Disease Center, Prague Psychiatric Center, Prague, Czech Republic. kristofikova@pcp.lf3.cuni.cz
authors.forename: Petra
authors.initials: P
authors.lastname: Hovorkova
authors.forename: Zdena
authors.initials: Z
authors.lastname: Kristofikova
authors.forename: Ales
authors.initials: A
authors.lastname: Horinek
authors.forename: Daniela
authors.initials: D
authors.lastname: Ripova
authors.forename: Emerich
authors.initials: E
authors.lastname: Majer
authors.forename: Petr
authors.initials: P
authors.lastname: Zach
authors.forename: Pavel
authors.initials: P
authors.lastname: Sellinger
authors.forename: Jan
authors.initials: J
authors.lastname: Ricny