The relationship between estimated glomerular filtration rate and thyroid function: an observational study.
BACKGROUND
Estimated glomerular filtration rate (eGFR) is now routinely reported by most National Health Service laboratories. There are many limitations when interpreting eGFR: thyroid dysfunction is not widely recognized as being one of these.


METHODS
We extracted from the pathology computer system results of all patients with hypothyroidism and hyperthyroidism who also had serum creatinine measured. We also extracted creatinine data on euthyroid patients. eGFR was calculated using the simplified Modification of Diet in Renal Disease Study equation.


RESULTS
The median eGFRs of the hypothyroid, euthyroid and hyperthyroid patients were 64, 77 and 107 mL/min/1.73 m(2), respectively; all groups were significantly different from each other (P < 0.001).


CONCLUSIONS
Thyroid dysfunction is associated with significant alterations in eGFR and actual GFR.
Woodward
Anne
A
Department of Clinical Biochemistry, Whiston Hospital, Warrington Road, Merseyside, UK.
McCann
Steven
S
Al-Jubouri
Mohammad
M