title: Utility of cyclodextrins in the formulation of genistein part 1. Preparation and physicochemical properties of genistein complexes with native cyclodextrins.
abstract: Isoflavones are suitable guest molecules for inclusion complex formation with cyclodextrins (CDs). The molecular encapsulation with CDs results in a solid, molecularly dispersed form and in a significantly improved aqueous solubility of isoflavones. Genistein, a key isoflavone constituent of Ononidis spinosae radix was found to form a supramolecular, non-covalent inclusion complex with both beta-cyclodextrin (beta-CD) and gamma-cyclodextrin (gamma-CD), while it did not form a stable complex with alpha-CD. The guest genistein was found to spatially located in the less polar cavity of cyclodextrin. The isolated binary genistein/CD complexes appeared novel crystalline lattices. The in vitro dissolution of genistein entrapped into both beta- and gamma-CD, significantly surpassed that of the plain isoflavone.
authors.affiliation: Department of Pharmacognosy, Semmelweis University, Ulloi út 26, H-1085 Budapest, Hungary. daruhazia@yahoo.com
authors.forename: Agnes Emma
authors.initials: AE
authors.lastname: Daruházi
authors.forename: Lajos
authors.initials: L
authors.lastname: Szente
authors.forename: Balázs
authors.initials: B
authors.lastname: Balogh
authors.forename: Péter
authors.initials: P
authors.lastname: Mátyus
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Béni
authors.forename: Mária
authors.initials: M
authors.lastname: Takács
authors.forename: András
authors.initials: A
authors.lastname: Gergely
authors.forename: Péter
authors.initials: P
authors.lastname: Horváth
authors.forename: Eva
authors.initials: E
authors.lastname: Szoke
authors.forename: Eva
authors.initials: E
authors.lastname: Lemberkovics