title: Percutaneous laser ablation of benign and malignant thyroid nodules.
abstract: OBJECTIVE
  Percutaneous image-guided procedures, largely based on thermal ablation, are at present under investigation for achieving a nonsurgical targeted cytoreduction in benign and malignant thyroid lesions.
  
  
  RESULTS
  In several uncontrolled clinical trials and in two randomized clinical trials, laser ablation has demonstrated a good efficacy and safety for the shrinkage of benign cold thyroid nodules. In hyperfunctioning nodules, laser ablation induced a nearly 50% volume reduction with a variable frequency of normalization of thyroid-stimulating hormone levels. Laser ablation has been tested for the palliative treatment of poorly differentiated thyroid carcinomas, local recurrences or distant metastases.
  
  
  CONCLUSIONS
  Laser ablation therapy is indicated for the shrinkage of benign cold nodules in patients with local pressure symptoms who are at high surgical risk. The treatment should be performed only by well trained operators and after a careful cytological evaluation. Laser ablation does not seem to be consistently effective in the long-term control of hyperfunctioning thyroid nodules and is not an alternative treatment to 131I therapy. Laser ablation may be considered for the cytoreduction of tumor tissue prior to external radiation therapy or chemotherapy of local or distant recurrences of thyroid malignancy that are not amenable to surgical or radioiodine treatment.
authors.affiliation: Department of Endocrinology, Regina Apostolorum Hospital, Albano, Rome, Italy. enrico.papini@fastwebnet.it
authors.forename: Enrico
authors.initials: E
authors.lastname: Papini
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Bizzarri
authors.forename: Claudio M
authors.initials: CM
authors.lastname: Pacella