title: N-alkyl-5H-pyrido[4,3-b]indol-1-amines and derivatives as novel urotensin-II receptor antagonists.
abstract: High throughput screening of our compound collection led to the discovery of a novel series of N-alkyl-5H-pyrido[4,3-b]indol-1-amines as urotensin-II receptor antagonists. Synthesis, initial structure and activity relationships, functional and animal ortholog activities of the series are described.
authors.affiliation: Oncology CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA. yonghui.2.wang@gsk.com <yonghui.2.wang@gsk.com>
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Wang
authors.forename: Zining
authors.initials: Z
authors.lastname: Wu
authors.forename: Brian F
authors.initials: BF
authors.lastname: Guida
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Lawrence
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Neeb
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Rivero
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Douglas
authors.forename: Jian
authors.initials: J
authors.lastname: Jin