title: Correlation between synovial fluid and serum IL-1beta levels after ACL surgery-preliminary report.
abstract: The possibility of controlling the harmful intra-articular influence of elevated interleukin (IL)-1beta synovial fluid concentration after anterior cruciate ligament (ACL) surgery could be useful. We investigated the correlation between serum and synovial fluid IL-1beta levels following ACL reconstruction. We measured IL-1beta concentration periodically in three synovial fluid and four serum samples in each of 20 patients receiving either autologous conditioned serum (ACS) containing endogenous anti-inflammatory cytokines including IL-1Ra and several growth factors (group A) or placebo (group B). A decrease in IL-1beta synovial fluid concentration appeared to be more pronounced in absolute terms in group A. In eight patients serum IL-1beta was detected on the 6th postoperative day. In four of them whose synovial fluid levels were over 10 pg/ml on the 6th postoperative day, serum IL-1beta was detected on the 10th postoperative day. The results were different in group B. Correlation between serum and synovial fluid IL-1beta appearance persists in patients after ACL surgery and ACS application. This study is an example of ACS influence on the ACL healing process controlling the IL-1beta levels on the basis of the serum IL-1beta detection.
authors.affiliation: Department of General Surgery and Traumatology, General Hospital Varazdin, Varazdin, Croatia. darabos.dr@vz.t-com.hr
authors.forename: Nikica
authors.initials: N
authors.lastname: Darabos
authors.forename: Zeljka
authors.initials: Z
authors.lastname: Hundric-Haspl
authors.forename: Miroslav
authors.initials: M
authors.lastname: Haspl
authors.forename: Alemka
authors.initials: A
authors.lastname: Markotic
authors.forename: Anela
authors.initials: A
authors.lastname: Darabos
authors.forename: Carsten
authors.initials: C
authors.lastname: Moser