title: Abortive aphthous-like oral lesions: an underreported initial presentation of pemphigus vulgaris.
abstract: BACKGROUND
  Pemphigus vulgaris (PV) usually presents as non-healing, painful oral erosions, but transient or aphtha-like lesions are not exceptional at the very beginning of the disease leading to the common misdiagnosis of recurrent aphthous stomatitis (RAS). We designed this cross-sectional, questionnaire-based study to evaluate this underreported yet important presentation of PV.
  
  
  METHODS
  One hundred and eighty-five consecutive PV patients were interviewed and a questionnaire, comprising items related to the natural history of oral lesions, was filled in for each. Fourteen patients who had taken steroids (topical or systemic) before their final diagnosis were excluded.
  
  
  RESULTS
  Twenty-three per cent of patients gave a history of transient aphthous-like lesions; 95% of them were misdiagnosed as aphthae. These lesions were especially reported by patients aged 40 years or older (P < 0.047).
  
  
  CONCLUSIONS
  PV should be kept in mind as a rare differential diagnosis of transient oral ulcerations. We recommend careful observation of these patients and performing indirect immunofluorescence or desmoglein ELISA and even biopsy in atypical cases, to rule out PV especially in older patients and predisposed ethic groups. To find out the differential aspects of RAS and aphthous-like PV, a cohort study on RAS patients is suggested.
authors.affiliation: Department of Dermatology, Autoimmune Bullous Diseases Research Center, Tehran, Iran. daneshpj@sina.tums.ac.ir
authors.forename: M
authors.initials: M
authors.lastname: Daneshpazhooh
authors.forename: C
authors.initials: C
authors.lastname: Chams-Davatchi
authors.forename: A
authors.initials: A
authors.lastname: Ramezani
authors.forename: F
authors.initials: F
authors.lastname: Moinedin
authors.forename: M Rezaei
authors.initials: MR
authors.lastname: Hemami