title: Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivatives.
abstract: A new series of betulinic acid derivatives have been synthesized by introducing heterocyclic ring between C-2 and C-3 positions of betulinic acid. Further modifications were also carried out by reduction of C-20(29) unsaturated bond and substitution of C-28 carboxyl group by ester and amide linkage to enhance the selectivity. Compound 11 resulted in IC(50) of 2.44, 2.5, and 2.7 microg/ml on MIAPaCa, PA-1, and SW620 cancer cell lines, respectively. Compound 38 resulted in IC(50) of 0.67 microg/ml on MIAPaCa cell line.
authors.affiliation: Chemical Research, Dabur Research Foundation, 22, Site IV, Sahibabad, Ghaziabad 201010, UP, India. kumarv@dabur.com
authors.forename: Vivek
authors.initials: V
authors.lastname: Kumar
authors.forename: Nidhi
authors.initials: N
authors.lastname: Rani
authors.forename: Pawan
authors.initials: P
authors.lastname: Aggarwal
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Sanna
authors.forename: Anu T
authors.initials: AT
authors.lastname: Singh
authors.forename: Manu
authors.initials: M
authors.lastname: Jaggi
authors.forename: Narendra
authors.initials: N
authors.lastname: Joshi
authors.forename: Pramod K
authors.initials: PK
authors.lastname: Sharma
authors.forename: Raghuveer
authors.initials: R
authors.lastname: Irchhaiya
authors.forename: Anand C
authors.initials: AC
authors.lastname: Burman