title: Synthesis of bioactive HEMA-MPS-CaCl2 hybrid gels: effects of catalysts in the sol-gel processing on mechanical properties and in vitro hydroxyapatite formation in a simulated body fluid.
abstract: We investigated synthetic conditions for the fabrication of bioactive hybrid gels from monomers of 2-hydroxyethylmethacrylate (HEMA) and 3-methacryloxypropyltrimethoxysilane (MPS) in combination with CaCl(2), at a starting molar ratio of HEMA: MPS : CaCl(2) of 9 : 1 : 1. Hydroxyapatite formation, essential to show bone bonding, was observed on the HEMA- MPS-CaCl( 2) hybrid gels with the added catalysts NH(3) or HCl with a molar ratio to MPS of 0.1, but not on the hybrid gel with HCl at a molar ratio to MPS of 1. The mechanical properties of the gels were dependent on the catalysts, which may affect the microstructures that develop during sol-gel processing.
authors.affiliation: Research Institute of Pharmaceutical Sciences Musashino University, 1-1-20 Shinmachi Nishitokyo-shi, Tokyo 202-8585, Japan. t_uchino@musashino-u.ac.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Uchino
authors.forename: Chikara
authors.initials: C
authors.lastname: Ohtsuki
authors.forename: Masanobu
authors.initials: M
authors.lastname: Kamitakahara
authors.forename: Toshiki
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hayakawa
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Osaka