Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.
Inflammatory bowel disease (IBD) is a common inflammatory disorder with complex etiology that involves both genetic and environmental triggers, including but not limited to defects in bacterial clearance, defective mucosal barrier and persistent dysregulation of the immune response to commensal intestinal bacteria. IBD is characterized by two distinct phenotypes: Crohn's disease (CD) and ulcerative colitis (UC). Previously reported GWA studies have identified genetic variation accounting for a small portion of the overall genetic susceptibility to CD and an even smaller contribution to UC pathogenesis. We hypothesized that stratification of IBD by age of onset might identify additional genes associated with IBD. To that end, we carried out a GWA analysis in a cohort of 1,011 individuals with pediatric-onset IBD and 4,250 matched controls. We identified and replicated significantly associated, previously unreported loci on chromosomes 20q13 (rs2315008[T] and rs4809330[A]; P = 6.30 x 10(-8) and 6.95 x 10(-8), respectively; odds ratio (OR) = 0.74 for both) and 21q22 (rs2836878[A]; P = 6.01 x 10(-8); OR = 0.73), located close to the TNFRSF6B and PSMG1 genes, respectively.
Kugathasan
Subra
S
Department of Pediatrics, Children's Research Institute and Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Baldassano
Robert N
RN
Bradfield
Jonathan P
JP
Sleiman
Patrick M A
PM
Imielinski
Marcin
M
Guthery
Stephen L
SL
Cucchiara
Salvatore
S
Kim
Cecilia E
CE
Frackelton
Edward C
EC
Annaiah
Kiran
K
Glessner
Joseph T
JT
Santa
Erin
E
Willson
Tara
T
Eckert
Andrew W
AW
Bonkowski
Erin
E
Shaner
Julie L
JL
Smith
Ryan M
RM
Otieno
F George
FG
Peterson
Nicholas
N
Abrams
Debra J
DJ
Chiavacci
Rosetta M
RM
Grundmeier
Robert
R
Mamula
Petar
P
Tomer
Gitit
G
Piccoli
David A
DA
Monos
Dimitri S
DS
Annese
Vito
V
Denson
Lee A
LA
Grant
Struan F A
SF
Hakonarson
Hakon
H