Artificial enzymes with thiazolium and imidazolium coenzyme mimics.
Hydrophobic thiazolium and imidazolium coenzyme mimics in the presence of modified-polyethylenimine enzyme mimics catalyze the benzoin condensation 2300-3300 times faster than the coenzyme mimics alone. Polycationic enzyme mimics provide not only a hydrophobic binding domain for coenzyme and substrate, but also electrostatic stabilization of anionic species that arise along the reaction pathway of the benzoin condensation.
Zhao
Huanyu
H
Department of Chemistry, Columbia University, New York, New York 10027, USA.
Foss
Frank W
FW
Breslow
Ronald
R