title: [Value of proton magnetic resonance spectroscopy with two-dimensional chemical-shift imaging in evaluating brain gliomas].
abstract: OBJECTIVE
  To study the value of proton magnetic resonance spectroscopy ((1)H-MRS) with two-dimensional (2D) chemical-shift imaging (CSI) in evaluating brain gliomas.
  
  
  METHODS
  Thirty-six patients with gliomas received examinations with 2D-CSI. The VOI of MRS included the tumor, peritumoral edematous and nonedematous areas, and the contralateral normal tissue. The changes of the metabolites in different areas were determined using 2D-CSI (1)H-MRS with SE sequence and the metabolite ratios were calculated.
  
  
  RESULTS
  Significant differences were found in the ratios of NAA/Cr, Cho/Cr and NAA/Cho between low-grade gliomas and contralateral normal brain tissue, and between high-grade gliomas and the contralateral normal tissue (P<0.01). The low-grade gliomas and high-grade gliomas differed significantly in the ratios of NAA/Cr, Cho/Cr and NAA/Cho (P<0.05). These ratios also showed significant differences between peritumoral edematous area and the glioma tissue, between the peritumoral edematous area and contralateral normal brain tissue (P<0.05), and between the peritumoral nonedematous area and the glioma tissue (P<0.05). Between the peritumoral nonedematous area and contralateral normal brain tissue, NAA/Cr and NAA/Cho ratios were significantly different (P<0.05) but the Cho/Cr ratio was similar (P>0.05).
  
  
  CONCLUSIONS
  MRS with 2D-CSI can provide precise and effective evidences with high time resolution for glioma grading, assessment of peritumoral involvement and glioma therapies.
authors.affiliation: Department of Radiology, Xiangya Hospital of Central South University, Changsha 410008, China.
authors.forename: Gao-feng
authors.initials: GF
authors.lastname: Zhou
authors.forename: Xiao-yi
authors.initials: XY
authors.lastname: Wang
authors.forename: Cai-gui
authors.initials: CG
authors.lastname: Gong
authors.forename: Fan
authors.initials: F
authors.lastname: Liu
authors.forename: Run-wen
authors.initials: RW
authors.lastname: Wang