title: Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands.
abstract: A series of non-imidazole histamine H(3) receptor antagonists based on the (3-phenoxypropyl)amine motif, which is a common pharmacophore for H(3) antagonists, has been identified. A preliminary SAR study around the amine moiety has identified 8a as a potent H(3) antagonist possessing a good pharmacokinetic profile in the rat.
authors.affiliation: The Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033-1300, USA. robert.aslanian@spcorp.com
authors.forename: Robert
authors.initials: R
authors.lastname: Aslanian
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Zhu
authors.forename: Henry A
authors.initials: HA
authors.lastname: Vaccaro
authors.forename: Neng-Yang
authors.initials: NY
authors.lastname: Shih
authors.forename: John J
authors.initials: JJ
authors.lastname: Piwinski
authors.forename: Shirley M
authors.initials: SM
authors.lastname: Williams
authors.forename: Robert E
authors.initials: RE
authors.lastname: West