Fast repair of purine deoxynucleotide radical cations by rutin and quercetin.
Repair effects of rutin and quercetin on purine deoxynucleotide radical cations were studied using pulse radiolysis technique. On electron pulse irradiation of N(2) saturated deoxynucleotide aqueous solution containing 20 mmol/L K(2)S(2)O(8), 200 mmol/L t-BuOH and rutin or quercetin, the transient absorption spectra of the deoxynucleotide radical cations decayed quickly. At the same time, the spectra of flavonoid phenoxyl radicals formed within several dozen microseconds. The results indicated that deoxynucleotide radical cations can be repaired by flavonoids. The rate constants of the repair reactions were 3.8 x10(8)-4.4 x10(8) mol(-1) * L * s(-1) and 1.3x10(8)-1.8x10(8) mol(-1) * L * s(-1) for dAMP and dGMP radical cations, respectively.
Zhao
C
C
Lanzhou University, China.
Shi
Y
Y
Wang
W
W
Jia
Z
Z
Yao
S
S
Fan
B
B
Zheng
R
R