title: A Samarium(II)-mediated, stereoselective cyclization for the synthesis of azaspirocycles.
abstract: Unsaturated keto-lactams undergo sequential conjugate reduction-aldol cyclization on treatment with SmI 2 to give syn-spirocyclic pyrrolidinones and piperidinones containing vicinal, fully substituted stereocenters with complete diastereocontrol. The substituent on nitrogen and the lactam ring size have a marked impact on the efficiency of the spirocyclization.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK. david.j.procter@manchester.ac.uk
authors.forename: Giuditta
authors.initials: G
authors.lastname: Guazzelli
authors.forename: Lorna A
authors.initials: LA
authors.lastname: Duffy
authors.forename: David J
authors.initials: DJ
authors.lastname: Procter