title: Design, synthesis, and anti-tumor evaluation of novel symmetrical bis-benzimidazoles.
abstract: A novel symmetrical bis-benzimidazole was designed as DNA minor groove binder. Molecular modeling study showed that it could dock into the minor groove of DNA. Several derivatives were synthesized and confirmed by IR, MS, and (1)H NMR. All these novel compounds were screened for cytotoxic activity on SKOV-3, HeLa, and BGC-823 cell lines in vitro. Some compounds showed IC(50)s in the single-digit micromolar range for cytotoxicity in several tumor cell lines.
authors.affiliation: Key Lab of New Drugs Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Yang
authors.forename: Mao-Sheng
authors.initials: MS
authors.lastname: Cheng
authors.forename: Qing-He
authors.initials: QH
authors.lastname: Wang
authors.forename: Han
authors.initials: H
authors.lastname: Nie
authors.forename: Na
authors.initials: N
authors.lastname: Liao
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Chen