title: Langerhans cell histiocytosis in a premature baby presenting with skin-isolated disease: case report and literature review.
abstract: Langerhans cell histiocytosis (LCH) in premature babies is extremely rare as is a vesicular skin rash, while gastrointestinal involvement is associated with a poor outcome. We report a case of LCH in a premature baby presented with isolated vesiculo-papulo-macular skin lesions and insidiously developed gastrointestinal symptoms, haematological and severe pulmonary involvement. We also reviewed a few cases of LCH in premature babies in the English language medical literature. LCH in preterm babies appears to be a severe systemic disease, usually lethal in-utero or post delivery.
  
  
  CONCLUSIONS
  Careful observation should be applied to newborns with skin-only Langerhans cell histiocytosis in order to identify in time progression to potentially fatal systemic disease.
authors.affiliation: Department of Pediatrics, The Barzilai Medical Center, Ashkelon, Israel. aviners@barzi.health.gov.il
authors.forename: Shraga
authors.initials: S
authors.lastname: Aviner
authors.forename: Meir
authors.initials: M
authors.lastname: Ronen
authors.forename: Daniel
authors.initials: D
authors.lastname: London
authors.forename: Ana
authors.initials: A
authors.lastname: Tobar
authors.forename: Shmuel
authors.initials: S
authors.lastname: Zangen