Utility of cyclodextrins in the formulation of genistein part 1. Preparation and physicochemical properties of genistein complexes with native cyclodextrins.
Isoflavones are suitable guest molecules for inclusion complex formation with cyclodextrins (CDs). The molecular encapsulation with CDs results in a solid, molecularly dispersed form and in a significantly improved aqueous solubility of isoflavones. Genistein, a key isoflavone constituent of Ononidis spinosae radix was found to form a supramolecular, non-covalent inclusion complex with both beta-cyclodextrin (beta-CD) and gamma-cyclodextrin (gamma-CD), while it did not form a stable complex with alpha-CD. The guest genistein was found to spatially located in the less polar cavity of cyclodextrin. The isolated binary genistein/CD complexes appeared novel crystalline lattices. The in vitro dissolution of genistein entrapped into both beta- and gamma-CD, significantly surpassed that of the plain isoflavone.
Daruházi
Agnes Emma
AE
Department of Pharmacognosy, Semmelweis University, Ulloi út 26, H-1085 Budapest, Hungary. daruhazia@yahoo.com
Szente
Lajos
L
Balogh
Balázs
B
Mátyus
Péter
P
Béni
Szabolcs
S
Takács
Mária
M
Gergely
András
A
Horváth
Péter
P
Szoke
Eva
E
Lemberkovics
Eva
E