title: [New marker in thrombotic thrombocytopenic purpura].
abstract: Thrombotic microangiopathy can be caused by several conditions which are difficult to diagnose from the clinical presentation alone. Deficient enzyme activity of a newly-discovered enzyme, ADAMTS-13, can lead to thrombotic thrombocytopenic purpura (TTP). Lack of ADAMTS-13 activity causes increased concentrations of high molecular weight von Willebrand factor forms and increased platelet aggregation. Measurement of ADAMTS-13 activity is useful for the diagnosis of TTP and may also be relevant as a prognostic test for recurrent TTP.
authors.affiliation: Rigshospitalet, Klinisk Biokemisk Afdeling, Københavns Universitet, Biomedicinsk Institut, København Ø.
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Gøtze
authors.forename: Andreas
authors.initials: A
authors.lastname: Hillarp
authors.forename: Anders
authors.initials: A
authors.lastname: Lindblom
authors.forename: Peter
authors.initials: P
authors.lastname: Björk
authors.forename: Karin
authors.initials: K
authors.lastname: Strandberg
authors.forename: Lars Bo
authors.initials: LB
authors.lastname: Nielsen