title: Beta-thalassemia mutations in western India.
abstract: OBJECTIVE
  To study occurrence of common mutations in the population of Gujarat and the most prevalent mutation in certain high-risk communities.
  
  
  METHODS
  The mutation screening was carried out using ARMS-PCR in children with beta thalassemia.
  
  
  RESULTS
  Population screening has identified certain communities like Sindhis, Lohana, Rajputs, and SC/ST/OBC to be at higher risk as compared to others. The most common mutation was IVS 1-5 (G-->C) followed by 619 bp deletions of the total cases coming to Gujarat.
  
  
  CONCLUSIONS
  Molecular evaluation for Thalassemia should be considered for families whose ethnicity indicates origin from high-risk community.
authors.affiliation: FRIGE Institute of Human Genetics, FRIGE House, Satellite, Ahmedabad, India. jshethad1@sancharnet.in
authors.forename: J J
authors.initials: JJ
authors.lastname: Sheth
authors.forename: F J
authors.initials: FJ
authors.lastname: Sheth
authors.forename: Pooja
authors.initials: P
authors.lastname: Pandya
authors.forename: Rashi
authors.initials: R
authors.lastname: Priya
authors.forename: Sejal
authors.initials: S
authors.lastname: Davla
authors.forename: Chitra
authors.initials: C
authors.lastname: Thakur
authors.forename: Vaz
authors.initials: V
authors.lastname: Flavin