title: Hofmeister effect and the phase diagram of lysozyme.
abstract: The phase diagrams for lysozyme are calculated for two different precipitant salts, NaCl and NaSCN, using a potential of mean force that takes into account contributions from ion-dispersion forces [M. Boström, J. Phys. Chem. B 110, 24757 (2006)]. Our results are consistent with a recent perturbation theory calculation (referenced above) in that the phase diagram for lysozyme with NaCl is quite different than for lysozyme with NaSCN for the same molar concentration (0.2M) . However, in contrast to the perturbation theory calculation, we find that the lysozyme phase diagram with NaCl has a metastable fluid-fluid coexistence curve and that the metastability gap in the case of NaSCN is much larger than predicted by perturbation theory.
authors.affiliation: Department of Physics, Lehigh University, Bethlehem, Pennsylvania 18015, USA.
authors.forename: S
authors.initials: S
authors.lastname: Lettieri
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Li
authors.forename: J D
authors.initials: JD
authors.lastname: Gunton