title: Synthesis and antitumor activity of mechercharmycin A analogues.
abstract: Several analogues of the cytotoxic thiopeptide IB-01211 or mechercharmycin A (1) have been synthesized. The cytotoxicity of 1 and the synthesized analogues were evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives 2 and 3c were chosen for further studies on effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis were detected.
authors.affiliation: Institute for Research in Biomedicine, Barcelona Science Park-University of Barcelona, Baldiri Reixac 10, E-08028 Barcelona, Spain.
authors.forename: Delia
authors.initials: D
authors.lastname: Hernández
authors.forename: Marta
authors.initials: M
authors.lastname: Altuna
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuevas
authors.forename: Rosa
authors.initials: R
authors.lastname: Aligué
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
authors.forename: Mercedes
authors.initials: M
authors.lastname: Alvarez