title: Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7.
abstract: Necroptosis is a regulated caspase-independent cell death mechanism characterized by morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel potent small-molecule inhibitor of necroptosis, is structurally distinct from previously described necrostatins (Nec-1, Nec-3, Nec-4 and Nec-5). Here, we describe a series of structural modifications and the structure-activity relationship (SAR) of the Nec-7 series for inhibiting necroptosis.
authors.affiliation: State Key Laboratory of Bio-organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
authors.forename: Weihong
authors.initials: W
authors.lastname: Zheng
authors.forename: Alexei
authors.initials: A
authors.lastname: Degterev
authors.forename: Emily
authors.initials: E
authors.lastname: Hsu
authors.forename: Junying
authors.initials: J
authors.lastname: Yuan
authors.forename: Chengye
authors.initials: C
authors.lastname: Yuan