Catalytic asymmetric conjugate addition of grignard reagents to alpha,beta-unsaturated sulfones.
A highly efficient method is reported for the asymmetric conjugate addition of Grignard reagents to alpha,beta-unsaturated 2-pyridylsulfones. Using a Cu/TolBinap complex, excellent enantioselectivities and high yields are obtained for a wide variety of aliphatic substrates.
Bos
Pieter H
PH
Stratingh Institute for Chemistry,University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Minnaard
Adriaan J
AJ
Feringa
Ben L
BL