title: Roles and interactions of Burkholderia pseudomallei BpsIR quorum-sensing system determinants.
abstract: The Burkholderia pseudomallei quorum-sensing system (QSS), designated BpsIR, is encoded by five bpsR genes and three bpsI genes. This study investigated the roles and interactions of the QSS determinants in terms of gene regulation and protein interaction. We report two novel findings, that BpsR can function as an activator and a repressor for bpsI expression and that BpsR may form homodimers and heterodimers.
authors.affiliation: Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Prannok Rd., Bangkok-Noi, Bangkok 10700, Thailand. sipkr@mahidol.ac.th
authors.forename: Pattarachai
authors.initials: P
authors.lastname: Kiratisin
authors.forename: Sittinee
authors.initials: S
authors.lastname: Sanmee