title: Isolation and characterization of low-molecular-weight chromium-binding substance (LMWCr) from chicken liver.
abstract: Chromodulin (also known as low-molecular-weight chromium-binding substance, LMWCr) is a chromium-binding oligopeptide proposed to play a role in insulin signaling and chromium transport in mammals. This laboratory has isolated and purified this material from a non-mammalian source, an avian. Spectroscopic and physical characterization of the isolated material suggests the material is an oligopeptide with a multinuclear chromium assembly bridged via asparatate and glutamate residues very similar to its mammalian counterparts. The isolated material also possesses a biological activity similar to other LMWCr isolates.
authors.affiliation: Department of Chemistry, Georgia Southern University, Statesboro, GA 30460-8064, USA.
authors.forename: Margarita
authors.initials: M
authors.lastname: Viera
authors.forename: C Michele
authors.initials: CM
authors.lastname: Davis-McGibony