A sequential metal-catalyzed C-N bond formation in the synthesis of 2-amido-indoles.
A sequential metal-catalyzed C-N bond formation employing ortho-haloaryl acetylenic bromides is described. The initial amidation is highly selective for C (sp)-N bond formation, leading to o-haloaryl-substituted ynamides that can be useful building blocks, while the overall sequence provides a facile construction of 2-amido-indoles.
Yao
Pei-Yuan
PY
Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, USA.
Zhang
Yu
Y
Hsung
Richard P
RP
Zhao
Kang
K