A role of IgE and CD23/NO immune pathway in age-related resistance of Lewis rats to Plasmodium berghei Anka?
In contrast to young rats, adult rats given i.p. Plasmodium berghei Anka (PbA) control the parasitaemia and repair their anaemia. Here, we investigated whether IgE and CD23/NO immune pathway could be implicated in this age-related resistance of adult rats to PbA. Eight-week-old rats displayed significantly higher levels of plasma total IgE (p=0.01) and soluble CD23 (p=0.003) during the peak of parasitaemia, compared to 4-week-old rats. IgE Fc-binding antibody or aminoguanidine administration to parasitized 8-week-old rats slightly delayed blood parasite clearance or exacerbated anaemia. These data suggest that IgE and CD23/NO could play an important role in the resistance of adult rats experiencing PbA primary intraerythrocytic development.
Safeukui
Innocent
I
EA 3677, Bases thérapeutiques des inflammations et infections, Université Victor Segalen Bordeaux II, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. safeukui@pasteur.fr
Vatan
Rémi
R
Dethoua
Mariette
M
Agbo
Hervé
H
Haumont
Gilbert
G
Moynet
Daniel
D
Malvy
Denis
D
Vincendeau
Philippe
P
Mossalayi
Djavad
D
Millet
Pascal
P