title: Caveolin and proteasome in tocotrienol mediated myocardial protection.
abstract: The effect of different isomers of tocotrienol was tested on myocardial ischemia reperfusion injury. Although all of the tocotrienol isomers offered some degree of cardioprotection, gamma-tocotrienol was the most protective as evident from the result of myocardial apoptosis. To study the mechanism of tocotrienol mediated cardioprotection, we examined the interaction and/or translocation of different signaling components to caveolins and activity of proteasome. The results suggest that differential interaction of MAP kinases with caveolin 1/3 in conjuncture with proteasome stabilization play a unique role in tocotrienol mediated cardioprotection possibly by altering the availability of pro-survival and anti-survival proteins.
authors.affiliation: Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA.
authors.forename: Manika
authors.initials: M
authors.lastname: Das
authors.forename: Samarjit
authors.initials: S
authors.lastname: Das
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Saul R
authors.initials: SR
authors.lastname: Powell
authors.forename: Dipak K
authors.initials: DK
authors.lastname: Das