title: A sequential metal-catalyzed C-N bond formation in the synthesis of 2-amido-indoles.
abstract: A sequential metal-catalyzed C-N bond formation employing ortho-haloaryl acetylenic bromides is described. The initial amidation is highly selective for C (sp)-N bond formation, leading to o-haloaryl-substituted ynamides that can be useful building blocks, while the overall sequence provides a facile construction of 2-amido-indoles.
authors.affiliation: Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, USA.
authors.forename: Pei-Yuan
authors.initials: PY
authors.lastname: Yao
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung
authors.forename: Kang
authors.initials: K
authors.lastname: Zhao