[Oxidative stress in myocardial infarction and the efficiency of its correction with the drug Trimetazidine].
The purpose of the study was to assess efficiency of the use of trimetazidine (Preductal MR) in therapy of acute myocardial infarction (MI) on the grounds of examination of oxidative potential of erythrocytes and blood serum, antioxidative enzyme activity. Group of patients with acute small-focal, large-focal and transmural myocardial infarction, who received traditional therapy and in addition cytoprotective drug trimetazidine, was examined. Primary and secondary products of lipid peroxidation (LP), antioxidative enzymes were analyzed on 1st and 21st day after the beginning of anginous attack. Integral indices for estimation of LP and antioxidative potential were calculated. Primary and secondary products of LP in erythrocytes and blood serum in patients with acute MI were high in 1st day and did not recover to normal after combined therapy. Combined therapy of acute MI with the use of trimetazidine (Preductal MR) made possible to reduce LP, especially at small-focal MI because of increase in enzyme activity of glutathione reductase, glutathione peroxidase and superoxide dismutase with catalase activity retention. Transmural MI was characterized by decrease in blood glutathione reductase and catalase activity, retention of glutathione peroxidase and superoxide dismutase activity, and increase in thiols content.
Kurashvili
L V
LV
Ushakova
S V
SV