title: A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
abstract: We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 cases and 3,115 controls. We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13.32 (rs11083846, PRKD2; P = 3.96 x 10(-9)). These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL.
authors.affiliation: Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Di Bernardo
authors.forename: Dalemari
authors.initials: D
authors.lastname: Crowther-Swanepoel
authors.forename: Peter
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authors.lastname: Broderick
authors.forename: Emily
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authors.lastname: Webb
authors.forename: Gabrielle
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authors.lastname: Sellick
authors.forename: Ruth
authors.initials: R
authors.lastname: Wild
authors.forename: Kate
authors.initials: K
authors.lastname: Sullivan
authors.forename: Jayaram
authors.initials: J
authors.lastname: Vijayakrishnan
authors.forename: Yufei
authors.initials: Y
authors.lastname: Wang
authors.forename: Alan M
authors.initials: AM
authors.lastname: Pittman
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Sunter
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Hall
authors.forename: Martin J S
authors.initials: MJ
authors.lastname: Dyer
authors.forename: Estella
authors.initials: E
authors.lastname: Matutes
authors.forename: Claire
authors.initials: C
authors.lastname: Dearden
authors.forename: Tryfonia
authors.initials: T
authors.lastname: Mainou-Fowler
authors.forename: Graham H
authors.initials: GH
authors.lastname: Jackson
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Summerfield
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Harris
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Pettitt
authors.forename: Peter
authors.initials: P
authors.lastname: Hillmen
authors.forename: David J
authors.initials: DJ
authors.lastname: Allsup
authors.forename: James R
authors.initials: JR
authors.lastname: Bailey
authors.forename: Guy
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authors.lastname: Pratt
authors.forename: Chris
authors.initials: C
authors.lastname: Pepper
authors.forename: Chris
authors.initials: C
authors.lastname: Fegan
authors.forename: James M
authors.initials: JM
authors.lastname: Allan
authors.forename: Daniel
authors.initials: D
authors.lastname: Catovsky
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston