title: [Lipid peroxidation injury and endoplasmic reticulum stress in Al-induced apoptosis].
abstract: OBJECTIVE
  To study the role of lipid peroxidation injury and endoplasmic reticulum stress in Al-induced apoptosis.
  
  
  METHODS
  Neurons from 0-3 day rats were cultured and treated with different concentrations of AlCl3.6H2O. Morphologic changes of neurons and endoplasmic reticulum were observed under fluorescent and transmission electron microscope; activities of superoxide dismutase (SOD), malondialdehyde (MDA) and ATP enzymes were detected.
  
  
  RESULTS
  Typical morphologic changes in neurons apoptosis and endoplasmic reticulum were found under fluorescent and transmission electron microscope; SOD enzyme viability and ATP enzyme viability were significantly increased in the low-dosage group, but reduced in mid and high-dosage group (P < 0.01), whereas MDA levels decreased in the low-dosage group, but increased in mid and high-dosage group (P < 0.01).
  
  
  CONCLUSIONS
  Aluminum may induce neurons apoptosis, and lipid peroxidation injury in endoplasmic reticulum plays an important role in the apoptosis progression.
authors.affiliation: Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Qin-li
authors.initials: QL
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Ying-tao
authors.initials: YT
authors.lastname: Shi
authors.forename: Lin-ping
authors.initials: LP
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Qiu-ying
authors.initials: QY
authors.lastname: Li
authors.forename: Qiao
authors.initials: Q
authors.lastname: Niu