title: In-hospital mortality in non-variceal upper gastrointestinal bleeding Forrest 1 patients.
abstract: OBJECTIVE
  Non-variceal upper gastrointestinal bleeding (NVUGIB) is recognized world-wide as a common cause of emergency hospitalization, and it often represents a life-threatening event. The purpose of this prospective study was to assess in-hospital mortality in NVUGIB Forrest 1 patients admitted to the emergency unit owing to active bleeding.
  
  
  METHODS
  We enrolled all patients consecutively admitted to the emergency unit for NVUGIB, acutely bleeding at endoscopy (spurting or oozing). Demographic characteristics, clinical and biochemical parameters, endoscopic findings and treatments were evaluated.
  
  
  RESULTS
  Of a total of 142 patients (98 M (69%), mean age+/-SD=66+/-14 years), spurting (16 (11.3%)) and oozing (126 (88.7%)) were identified. All patients received endoscopic treatment within 6 h of admission and were managed according to the guidelines. Seventeen (12%) patients suffered rebleeding, 4 patients (2.8%) required surgery to stop the bleeding, and 8 (5.6%) died during hospitalization (4 within 5 days and the remainder within 24 days of admission) - 3 as a consequence of bleeding (2.1%) and 5 of non-surgical complications (3.5%). Cox regression analysis showed that the lesions in more than one segment of the esophagogastroduodenal tract (p=0.008, hazard ratio (95% CI)=7.623 (1.680-34.600)) and the number of blood units transfused during the first 48 h of hospitalization (p=0.038, 2.075 (1.041-4.135)) were predictive of in-hospital death.
  
  
  CONCLUSIONS
  In Forrest 1 patients given rapid endoscopic treatment, in-hospital mortality seems to be related to the contemporaneous presence of bleeding and non-bleeding lesions in more than one segment of the esophagogastroduodenal tract and the number of blood units transfused during the first 48 h of hospitalization.
authors.affiliation: A. Cardarelli Hospital, Gastroenterology Unit, Naples, Italy. manguso@alice.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Manguso
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Riccio
authors.forename: Raffaele
authors.initials: R
authors.lastname: Bennato
authors.forename: Salvatore
authors.initials: S
authors.lastname: Picascia
authors.forename: Rossana
authors.initials: R
authors.lastname: Martino
authors.forename: Germana
authors.initials: G
authors.lastname: De Nucci
authors.forename: Roberta
authors.initials: R
authors.lastname: Fiorito
authors.forename: Antonio
authors.initials: A
authors.lastname: Balzano