title: The safety of rosiglitazone in the treatment of type 2 diabetes.
abstract: BACKGROUND
  Cardiovascular disease is the leading cause of mortality among adults with Type 2 diabetes. The thiazolidinediones including rosiglitazone are approved for the treatment of Type 2 diabetes on the basis of their ability to lower blood sugar and surrogate markers of cardiovascular disease.
  
  
  OBJECTIVE
  To ascertain the cardiovascular, skeletal and hematologic safety profile of rosiglitazone.
  
  
  METHODS
  Synthesis of evidence from recent trials, systematic reviews, meta-analysis, regulatory documents and clinical trials registries of manufacturers.
  
  
  CONCLUSIONS
  Rosiglitazone increases the risk of heart failure, myocardial infarction and fractures (in women) with Type 2 diabetes.
authors.affiliation: Wake Forest University School of Medicine, Department of Medicine, Winston-Salem, NC 27103, USA. sosingh@wfubmc.edu
authors.forename: Sonal
authors.initials: S
authors.lastname: Singh
authors.forename: Yoon K
authors.initials: YK
authors.lastname: Loke