Interspecies recombination occurs frequently in quinolone resistance-determining regions of clinical isolates of Streptococcus pyogenes.
Fluoroquinolone resistance in Streptococcus pyogenes has been reported only anecdotally, but a recent Belgian surveillance study found a rate of nonsusceptibility of 5.4%. From an analysis of these isolates, we show that interspecies horizontal gene transfer within the parC quinolone resistance-determining region is a frequent phenomenon that might contribute to fluoroquinolone resistance.
Duesberg
Christoph B
CB
Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
Malhotra-Kumar
Surbhi
S
Goossens
Herman
H
McGee
Lesley
L
Klugman
Keith P
KP
Welte
Tobias
T
Pletz
Mathias W R
MW