Triple X syndrome with rare phenotypic presentation.
Triple X syndrome is a rare numerical chromosomal anomaly, occurring as a result of non dysjunction in meiosis I. Most cases have neurodevelopmental defects and functional problems. We report two cases diagnosed in our centre. The first was a fetus with cleft lip and palate, 47, XXX was identified by Fetal Blood Sampling. The second was a child with multisystem anomaly including cleft lip and palate, whose karyotype also revealed 47, XXX. Though isolated cases of associated abnormalities have been reported there have not been consistent phenotypic changes reported with this condition.
Jagadeesh
Sujatha
S
Department of Genetics, A Unit of Mediscan Systems, 197, Dr Natesan Road, Mylapore, Chennai, India. fcrfchennai@yahoo.com
Jabeen
Gazala
G
Bhat
Lathaa
L
Vasikarla
Madhavi
M
Suresh
Arvind
A
Seshadri
Suresh
S
Lata
S
S