title: A tal(in) of cell spreading.
abstract: Talin can activate integrins to bind the extracellular matrix and also connect matrix-engaged integrins to the actin cytoskeleton. New work shows that cell spreading can be dissected into three distinct phases according to their differential requirements for talin function.
authors.affiliation: Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR. m.frame@ed.ac.uk
authors.forename: Margaret
authors.initials: M
authors.lastname: Frame
authors.forename: Jim
authors.initials: J
authors.lastname: Norman