Synthesis of 2-cyclohexenone derivatives via gold(I)-catalyzed hydrative cyclization of 1,6-diynes.
The gold(I) complex (MeAuPPh3) was found to be a highly effective catalyst for the hydrative cyclization of 1,6-diynes to form the corresponding 3-methyl hex-2-enone derivatives with good to excellent yield. The proposed mechanism is described.
Zhang
Chen
C
ZJU-ENS Joint Laboratory of Medicinal Chemistry, School of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China. chenzhang@zju.edu.cn
Cui
Dong-Mei
DM
Yao
Li-Ying
LY
Wang
Bi-Song
BS
Hu
Yong-Zhou
YZ
Hayashi
Teruyuki
T