title: Artificial enzymes with thiazolium and imidazolium coenzyme mimics.
abstract: Hydrophobic thiazolium and imidazolium coenzyme mimics in the presence of modified-polyethylenimine enzyme mimics catalyze the benzoin condensation 2300-3300 times faster than the coenzyme mimics alone. Polycationic enzyme mimics provide not only a hydrophobic binding domain for coenzyme and substrate, but also electrostatic stabilization of anionic species that arise along the reaction pathway of the benzoin condensation.
authors.affiliation: Department of Chemistry, Columbia University, New York, New York 10027, USA.
authors.forename: Huanyu
authors.initials: H
authors.lastname: Zhao
authors.forename: Frank W
authors.initials: FW
authors.lastname: Foss
authors.forename: Ronald
authors.initials: R
authors.lastname: Breslow