Unexpected roles of scaffolding proteins in receptor patho-physiological functions.
It is well established that membrane receptors, transporters, and ion channels are organized into functional networks at the cell membrane by multiprotein complexes. The scaffolding proteins physically link these signaling membrane proteins to their intracellular effectors and actin skeleton. The last ten years of research in the field have revealed the nature, structure, and functions of some of these multiprotein complexes. Here, we will focus on those which are present at the excitatory glutamatergic synapse and describe some of their structural and functional aspects, as well as the main methods which are use to study them.
Fagni
Laurent
L
Institute of Funcitonal Genomics, INSERM-U661, Université Montpellier 1, 34000 Montpellier, France. laurent.fagni@igf.cnrs.fr
Bertaso
Federica
F
Perroy
Julie
J
Ango
Fabrice
F