OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease.
OBJECTIVE
To investigate the single nucleotide polymorphism (SNPs) distribution of NOD2/CARD15 (R702W, G908R), OCTN1 1672C/T and OCTN2-207G/C in Chinese patients with inflammatory bowel disease (IBD).


METHODS
A total of 61 patients with Crohn's disease (CD), 151 patients with ulcerative colitis (UC), and 200 unrelated healthy controls were genotyped. Genotyping was performed by sequence specific primer polymerase chain reaction (PCR-SSP) or by restriction fragment length polymorphism (PCR-RFLP) analysis.


RESULTS
Among the subjects in our study groups, including patients with CD, UC and healthy controls, none had OCTN and CARD15 variants and very rare IBD family history was found in our patients with the percentage of 0 (0/61 with CD) and 1.3% (2/151 with UC).


CONCLUSIONS
Our results indicate that although OCTN or CARD15 variation is associated with susceptibility to IBD in Western populations, these might be rare and may not be associated with susceptibility to IBD in Chinese patients.
Li
Mei
M
Department of Gastroenterology, the First Affiliated Hospital of Zhongshan University, Guangzhou 510089, Guangdong Province, China. pjhumd@vip.163.com
Gao
Xiang
X
Guo
Chang-Cun
CC
Wu
Kai-Chun
KC
Zhang
Xin
X
Hu
Pin-Jin
PJ