Chitosan salts coated with stearic acid as colon-specific delivery systems for vancomycin.
Site-specific controlled release systems have been extensively investigated during the last decade. The aim of this study was to describe a pH-dependent drug release system based on chitosan salts for vancomycin hydrochloride delivery. Chitosan salts with succinic acid, adipic acid, and suberic acid were prepared by spray-drying and were coated with stearic acid by the same technique. This study characterized the carriers in terms of morphology, size, swelling, mucoadhesive properties, and drug loading and focused on the in vitro, influence of chitosan salts on the release behavior of vancomycin hydrochloride from the uncoated and coated systems at pH levels of 2.0, 5.5, and 7.6.
Bigucci
Federica
F
Department of Pharmaceutical Sciences, Bologna University, Bologna, Italy. federica.bigucci@unibo.it
Luppi
Barbara
B
Musenga
Alessandro
A
Zecchi
Vittorio
V
Cerchiara
Teresa
T